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1

Learning genetic epistasis using Bayesian network scoring criteria  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Gene-gene epistatic interactions likely play an important role in the genetic basis of many common diseases. Recently, machine-learning and data mining methods have been developed for learning epistatic relationships from data. A well-known combinatorial method that has been successfully applied for detecting epistasis is Multifactor Dimensionality Reduction (MDR). Jiang et al. created a combinatorial epistasis learning method called BNMBL to learn Bayesian network (BN) epistatic models. They compared BNMBL to MDR using simulated data sets. Each of these data sets was generated from a model that associates two SNPs with a disease and includes 18 unrelated SNPs. For each data set, BNMBL and MDR were used to score all 2-SNP models, and BNMBL learned significantly more correct models. In real data sets, we ordinarily do not know the number of SNPs that influence phenotype. BNMBL may not perform as well if we also scored models containing more than two SNPs. Furthermore, a number of other BN scoring criteria have been developed. They may detect epistatic interactions even better than BNMBL. Although BNs are a promising tool for learning epistatic relationships from data, we cannot confidently use them in this domain until we determine which scoring criteria work best or even well when we try learning the correct model without knowledge of the number of SNPs in that model. Results We evaluated the performance of 22 BN scoring criteria using 28,000 simulated data sets and a real Alzheimer's GWAS data set. Our results were surprising in that the Bayesian scoring criterion with large values of a hyperparameter called ? performed best. This score performed better than other BN scoring criteria and MDR at recall using simulated data sets, at detecting the hardest-to-detect models using simulated data sets, and at substantiating previous results using the real Alzheimer's data set. Conclusions We conclude that representing epistatic interactions using BN models and scoring them using a BN scoring criterion holds promise for identifying epistatic genetic variants in data. In particular, the Bayesian scoring criterion with large values of a hyperparameter ? appears more promising than a number of alternatives.

Jiang Xia; Neapolitan Richard E; Barmada M Michael; Visweswaran Shyam

2011-01-01

2

Learning genetic epistasis using Bayesian network scoring criteria.  

UK PubMed Central (United Kingdom)

BACKGROUND: Gene-gene epistatic interactions likely play an important role in the genetic basis of many common diseases. Recently, machine-learning and data mining methods have been developed for learning epistatic relationships from data. A well-known combinatorial method that has been successfully applied for detecting epistasis is Multifactor Dimensionality Reduction (MDR). Jiang et al. created a combinatorial epistasis learning method called BNMBL to learn Bayesian network (BN) epistatic models. They compared BNMBL to MDR using simulated data sets. Each of these data sets was generated from a model that associates two SNPs with a disease and includes 18 unrelated SNPs. For each data set, BNMBL and MDR were used to score all 2-SNP models, and BNMBL learned significantly more correct models. In real data sets, we ordinarily do not know the number of SNPs that influence phenotype. BNMBL may not perform as well if we also scored models containing more than two SNPs. Furthermore, a number of other BN scoring criteria have been developed. They may detect epistatic interactions even better than BNMBL.Although BNs are a promising tool for learning epistatic relationships from data, we cannot confidently use them in this domain until we determine which scoring criteria work best or even well when we try learning the correct model without knowledge of the number of SNPs in that model. RESULTS: We evaluated the performance of 22 BN scoring criteria using 28,000 simulated data sets and a real Alzheimer's GWAS data set. Our results were surprising in that the Bayesian scoring criterion with large values of a hyperparameter called ? performed best. This score performed better than other BN scoring criteria and MDR at recall using simulated data sets, at detecting the hardest-to-detect models using simulated data sets, and at substantiating previous results using the real Alzheimer's data set. CONCLUSIONS: We conclude that representing epistatic interactions using BN models and scoring them using a BN scoring criterion holds promise for identifying epistatic genetic variants in data. In particular, the Bayesian scoring criterion with large values of a hyperparameter ? appears more promising than a number of alternatives.

Jiang X; Neapolitan RE; Barmada MM; Visweswaran S

2011-01-01

3

Criteria for measures of quantum correlations  

CERN Multimedia

Entanglement does not describe all quantum correlations and several authors have shown the need to go beyond entanglement when dealing with mixed states. Several different measures have sprung up in the literature, for a variety of reasons, To describe quantum correlations; some are known under the collective name quantum discord. Yet, in the same sprit as the criteria for entanglement measures, there is no general mechanism that determines whether a measure of quantum and classical correlations is a proper measure of correlations. This is partially due to the fact that the answer is a bit muddy. In this article we attempt tackle this muddy topic by writing down several criteria for a "good" measure of correlations. We breakup our list into necessary, reasonable, and debatable conditions. We then proceed to prove several of these conditions for generalized measures of quantum correlations. However, not all conditions are met by all measures; we show this via several examples. The reasonable conditions are rel...

Brodutch, Aharon

2011-01-01

4

Relationship between Praxis 1 Scores and SAT/ACT Scores: A Correlational Study  

Science.gov (United States)

The purpose of this paper is to test the premise that there is a significant correlation between Praxis1 scores and SAT scores among African American students who are applying for admission into the teacher education program. Data for the study included the Praxis 1 (reading, writing and math) scores and SAT (reading, writing and math) scores of…

Saravanabhavan, Sheila; Jones, Enid B.; Wilson, Carolyn H.

2005-01-01

5

Blastocyst quality scoring based on morphologic grading correlates with cell number.  

UK PubMed Central (United Kingdom)

Blastocyst quality score (BQS), first reported by Rehman et al., is a numerical blastocyst-morphology grading system based on the criteria established by Gardner and Schoolcraft. We demonstrate a positive correlation between the calculated BQS score and cell number by staining thawed human embryos and suggest that BQS can be applied to evaluate culture systems clinically.

Matsuura K; Hayashi N; Takiue C; Hirata R; Habara T; Naruse K

2010-08-01

6

Family physicians' completion of scoring criteria in virtual patient encounters  

Science.gov (United States)

The American Board of Family Medicine (ABFM) has used a 60-item Multiple Choice Question (MCQ) section followed by a Virtual Patient (VP) exercise in Maintenance Of Certification (MOC) since 2004, and has had an asthma module since 2005. The original asthma VP criteria anticipated some Expert Panel Report-3 recommendations, such as home peak flow monitoring and a written plan, that were added to the MCQ section only when the guideline was updated in 2007. VP completion rates for these criteria improved markedly with the MCQ update, while other criteria completion rates were stable. Asthma criteria completion rates are not predicted by the strength of evidence for the criteria. User interface details influence criteria completion rates, but did not affect the changes observed in 2007. Asthma MCQ content affects Diplomate performance on asthma VP: this translational step suggests that MOC exercises could result in improved care for real patients.

Sumner, Walton; O'Neill, Thomas R.; Roussel, Guy; Xu, Jin Zhong; Fu, Haiqi; Ivins, Doug; Hagen, Michael D.

2011-01-01

7

Family physicians' completion of scoring criteria in Virtual Patient encounters.  

UK PubMed Central (United Kingdom)

The American Board of Family Medicine (ABFM) has used a 60-item Multiple Choice Question (MCQ) section followed by a Virtual Patient (VP) exercise in Maintenance Of Certification (MOC) since 2004, and has had an asthma module since 2005. The original asthma VP criteria anticipated some Expert Panel Report-3 recommendations, such as home peak flow monitoring and a written plan, that were added to the MCQ section only when the guideline was updated in 2007. VP completion rates for these criteria improved markedly with the MCQ update, while other criteria completion rates were stable. Asthma criteria completion rates are not predicted by the strength of evidence for the criteria. User interface details influence criteria completion rates, but did not affect the changes observed in 2007. Asthma MCQ content affects Diplomate performance on asthma VP: this translational step suggests that MOC exercises could result in improved care for real patients.

Sumner W 2nd; O'Neill TR; Roussel G; Xu JZ; Fu H; Ivins D; Hagen MD

2011-01-01

8

Correlation between radiology resident rotation performance and examination scores.  

UK PubMed Central (United Kingdom)

RATIONALE AND OBJECTIVES: The authors' purpose was to determine whether there is a relationship between subjective assessment of radiology resident performance on individual rotations and objective assessment of radiology resident performance on the American College of Radiology (ACR) in-training and American Board of Radiology (ABR) written examinations. MATERIALS AND METHODS: Records of 81 radiology residents completing their residency between 1991 and 2000 were reviewed. Mean scores from all rotation evaluation forms obtained during the study period were calculated for each residency year. The means of the overall raw scores and percentiles obtained on the annual ACR in-training examinations during the first 3 years of residency and of the written portion of the ABR examination taken during the 4th year of residency were also determined. Rotation evaluation scores were then compared to examination scores obtained during the same year of residency, and correlation coefficients were obtained. RESULTS: In the 2nd, 3rd, and 4th years of radiology residency, there is positive correlation between rotation evaluation scores and overall scores from the corresponding ACR in-training examination and written portion of the ABR examination taken during the same year. In contrast, in the 1st year of residency, resident rotation evaluation scores do not correlate with ACR in-training examination scores. CONCLUSION: Residents who are perceived as doing well on their rotations after the 1st year of residency are more likely to do well on standardized written examinations.

Adusumilli S; Cohan RH; Korobkin M; Fitzgerald JT; Oh MS

2000-11-01

9

A Chronic Fatigue Syndrome (CFS) severity score based on case designation criteria.  

UK PubMed Central (United Kingdom)

BACKGROUND: Chronic Fatigue Syndrome case designation criteria are scored as physicians' subjective, nominal interpretations of patient fatigue, pain (headaches, myalgia, arthralgia, sore throat and lymph nodes), cognitive dysfunction, sleep and exertional exhaustion. METHODS: Subjects self-reported symptoms using an anchored ordinal scale of 0 (no symptom), 1 (trivial complaints), 2 (mild), 3 (moderate), and 4 (severe). Fatigue of 3 or 4 distinguished "Fatigued" from "Not Fatigued" subjects. The sum of the 8(Sum8) ancillary criteria was tested as a proxy for fatigue. All subjects had history and physical examinations to exclude medical fatigue, and ensure categorization as healthy or CFS subjects. RESULTS: Fatigued subjects were divided into CFS with ?4 symptoms or Chronic Idiopathic Fatigue (CIF) with ?3 symptoms. ROC of Sum8 for CFS and Not Fatigued subjects generated a threshold of 14 (specificity=0.934; sensitivity=0.928). CFS (n=256) and CIF (n=55) criteria were refined to include Sum8?14 and ?13, respectively. Not Fatigued subjects had highly skewed Sum8 responses. Healthy Controls (HC; n=269) were defined by fatigue?2 and Sum8?13. Those with Sum8?14 were defined as CFS-Like With Insufficient Fatigue Syndrome (CFSLWIFS; n=20). Sum8 and Fatigue were highly correlated (R(2)=0.977; Cronbach's alpha=0.924) indicating an intimate relationship between symptom constructs. Cluster analysis suggested 4 clades each in CFS and HC. Translational utility was inferred from the clustering of proteomics from cerebrospinal fluid. CONCLUSIONS: Plotting Fatigue severity versus Sum8 produced an internally consistent classifying system. This is a necessary step for translating symptom profiles into fatigue phenotypes and their pathophysiological mechanisms.

Baraniuk JN; Adewuyi O; Merck SJ; Ali M; Ravindran MK; Timbol CR; Rayhan R; Zheng Y; Le U; Esteitie R; Petrie KN

2013-01-01

10

Automatic sleep scoring in normals and in individuals with neurodegenerative disorders according to new international sleep scoring criteria  

DEFF Research Database (Denmark)

The aim of this study was to develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine. A biomedical signal processing algorithm was developed, allowing for automatic sleep depth quantification of routine polysomnographic recordings through feature extraction, supervised probabilistic Bayesian classification, and heuristic rule-based smoothing. The performance of the algorithm was tested using 28 manually classified day-night polysomnograms from 18 normal subjects and 10 patients with Parkinson disease or multiple system atrophy. This led to quantification of automatic versus manual epoch-by-epoch agreement rates for both normals and abnormals. Resulting average agreement rates were 87.7% (Cohen's Kappa: 0.79) and 68.2% (Cohen's Kappa: 0.26) in the normal and abnormal group, respectively. Based on an observed reliability of the manual scorer of 92.5% (Cohen's Kappa: 0.87) in the normal group and 85.3% (Cohen's Kappa: 0.73) in the abnormal group, this study concluded that although the developed algorithm was capable of scoring normal sleep with an accuracy around the manual interscorer reliability, it failed in accurately scoring abnormal sleep as encountered for the Parkinson disease/multiple system atrophy patients.

Jensen, Peter S; Sorensen, Helge B D

2010-01-01

11

Automatic Sleep Scoring in Normals and in Individuals with Neurodegenerative Disorders According to New International Sleep Scoring Criteria  

DEFF Research Database (Denmark)

The aim of this study was to develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine. A biomedical signal processing algorithm was developed, allowing for automatic sleep depth quantification of routine polysomnographic recordings through feature extraction, supervised probabilistic Bayesian classification, and heuristic rule-based smoothing. The performance of the algorithm was tested using 28 manually classified day-night polysomnograms from 18 normal subjects and 10 patients with Parkinson disease or multiple system atrophy. This led to quantification of automatic versus manual epoch-by-epoch agreement rates for both normals and abnormals. Resulting average agreement rates were 87.7% (Cohen's Kappa: 0.79) and 68.2% (Cohen's Kappa: 0.26) in the normal and abnormal group, respectively. Based on an observed reliability of the manual scorer of 92.5% (Cohen's Kappa: 0.87) in the normal group and 85.3% (Cohen's Kappa: 0.73) in the abnormal group, this study concluded that although the developed algorithm was capable of scoring normal sleep with an accuracy around the manual interscorer reliability, it failed in accurately scoring abnormal sleep as encountered for the Parkinson disease/multiple system atrophy patients.

Jensen, Peter S.; SØrensen, Helge Bjarup Dissing

2010-01-01

12

Defining the nociceptive flexion reflex (NFR) threshold in human participants: a comparison of different scoring criteria.  

Science.gov (United States)

Despite the widespread use of the nociceptive flexion reflex (NFR) paradigm in clinical and experimental pain research, there is currently no consensus on how best to define NFR threshold. Accordingly, the present studies were designed to assess the accuracy and reliability of different NFR threshold scoring criteria. Study 1 compared 13 scoring criteria in their accuracy for identifying the presence of the NFR, then generated empirically derived cut-points for the best criteria, and examined the test-retest reliability of NFR thresholds derived from these cut-points. Study 2 evaluated the replicability of these findings in an independent sample. Results from the two studies suggested that standardized peak (NFR Interval Peak z score) and mean (NFR Interval z score) biceps femoris electromyogram (EMG) activity were accurate and reliable criteria for defining NFR threshold. Acknowledging that cut-points may need to be adjusted for different research designs, graphs depicting sensitivity and specificity across a range of cut-points have been provided to facilitate researcher's decision-making. It is hoped that the results of these studies will promote a standard NFR threshold assessment methodology, and further encourage the application of the NFR paradigm in the investigation of mechanisms and characteristics of both painful and non-painful diseases. PMID:17070999

Rhudy, Jamie L; France, Christopher R

2006-10-27

13

Correlations between SAT scores and MCAT scores of black students in a summer program.  

UK PubMed Central (United Kingdom)

The purpose of the study reported here was to determine the relationship between Scholastic Aptitude Test (SAT) scores and Medical College Admission Test (MCAT) scores of black students who had participated in a summer program for minority students interested in health careers held at the Medical College of Georgia. A significant correlation was established between these students' SAT and MCAT scores. These findings suggest that students who are likely to perform well in medical school can be selected for medical school while they are still underclassmen, accepted conditionally, and admitted after completing a prescribed curriculum. Early selection has implications for increasing the number of minority students in medicine and for permitting more liberal arts in the premedical education than the present selection process.

Thurmond VB; Lewis L

1986-08-01

14

Propensity score analysis of exposure effects for spatially correlated data.  

UK PubMed Central (United Kingdom)

Spatial patterns in data have become an important feature to consider in the statistical analysis in medical research. The analysis of data from observational studies requires methods such as the propensity scores to create a quasi- andomized design. Considering first the case of no variates, we evaluated the ordinary and generalized least squares estimators, and corresponding variance estimators, or an effect of the exposure/treatment. In order to provide robust inference for spatially correlated data, a number of new methods for variance estimation were proposed and compared, including parametric spatial bootstrap, jackknife, and empirical variogram approaches. Next, the use of propensity scores based on spatially and non-patially correlated covariates was studied. Several propensity score and outcome models were evaluated along with the difference approaches to assessing balance and exposure effects. Performance of the methods was evaluated using simulation studies. In addition, the methods were applied to discharge data from California hospitals in2004 taken from the Healthcare Cost and Utilization Project (HCUP) State Inpatient Databases (SID). According to the simulation results, the ordinary least squares estimator with the empirical variance estimator was recommended in the absence of prior knowledge about underlying variance-covariance structure. Also, the empirical balance score was recommended for assessing the balance of a variable. Moreover, the simulation results showed that the exposure/treatment effect of the outcome model including all observed covariates and propensity scores did reduce the bias. Here, both outcome and propensity score models including all observed covariates were recommended. Applying these models to a real dataset, we found that the mean length of stay and the number of patients who died were lower for high-quality hospitals. In contrast, the median of total charges for low-quality hospitals was smaller.

Ou J

15

The Tower of London Test: different scoring criteria for diagnosing Alzheimer's disease and mild cognitive impairment.  

UK PubMed Central (United Kingdom)

The Tower of London (TOL) is used for evaluating planning skills, which is a component of the executive functions. Different versions and scoring criteria were developed for this task, and some of them present with different psychometrical properties. This study aimed to evaluate two specific scoring methods of the TOL in diagnosing Mild Cognitive Impairment and probable Alzheimer's disease. The TOL total scores from 60 patients of each diagnosis were compared with the performance of 60 healthy-aged controls using receiver operating characteristics analysis and multinomial logistic regression. Krikorian method better diagnosed Alzheimer's disease, while Portellas's was better at discriminating healthy controls from Mild Cognitive Impairment, but were not efficient at comparing this last group with Alzheimer's patients. Regression analysis indicates that in addition to screening tests, TOL improves the classification of the three groups. The results suggest the two scoring methods used for this task may be useful for different diagnostic purposes.

de Paula JJ; Moreira L; Nicolato R; de Marco LA; Côrrea H; Romano-Silva MA; de Moraes EN; Bicalho MA; Malloy-Diniz LF

2012-04-01

16

The Tower of London Test: different scoring criteria for diagnosing Alzheimer's disease and mild cognitive impairment.  

Science.gov (United States)

The Tower of London (TOL) is used for evaluating planning skills, which is a component of the executive functions. Different versions and scoring criteria were developed for this task, and some of them present with different psychometrical properties. This study aimed to evaluate two specific scoring methods of the TOL in diagnosing Mild Cognitive Impairment and probable Alzheimer's disease. The TOL total scores from 60 patients of each diagnosis were compared with the performance of 60 healthy-aged controls using receiver operating characteristics analysis and multinomial logistic regression. Krikorian method better diagnosed Alzheimer's disease, while Portellas's was better at discriminating healthy controls from Mild Cognitive Impairment, but were not efficient at comparing this last group with Alzheimer's patients. Regression analysis indicates that in addition to screening tests, TOL improves the classification of the three groups. The results suggest the two scoring methods used for this task may be useful for different diagnostic purposes. PMID:22662402

de Paula, Jonas Jardim; Moreira, Lafaiete; Nicolato, Rodrigo; de Marco, Luiz Armando; Côrrea, Humberto; Romano-Silva, Marco Aurélio; de Moraes, Edgar Nunes; Bicalho, Maria Aparecida; Malloy-Diniz, Leandro Fernandes

2012-04-01

17

Comparison of Hay's criteria with Nugent's scoring system for diagnosis of bacterial vaginosis.  

UK PubMed Central (United Kingdom)

Although Nugent's criterion is considered as the gold standard for the diagnosis of bacterial vaginosis (BV), the method requires an experienced slide reader and considerable time and skill. In this study, we compared the method of Hay and Ison with Nugent's scoring criteria. Vaginal specimens were collected from a total of 213 women, presenting with or without the symptoms of vaginitis. Diagnosis of BV was done using Nugent' and Hay's method. Sensitivity, specificity, and predictive values for positive and negative test were calculated for Hay's method using Nugent's method as the gold standard. We diagnosed 70 cases (32.86%) of BV by Nugent's method and 87 (40.85%) cases by the Hay's method. Sensitivity, specificity, predictive value of positive result, predictive value of negative result, and Kappa value when evaluating Hay's criteria using Nugent's criteria as the gold standard were ?97.2%, ?88.1%, ?80.4%, ?97.1%, and ?0.830, respectively, when Hay's grade II and/or Nugent's intermediate score were considered either as negative or positive or excluded. Using Nugent score for the intermediate group is the most difficult. Hay's method shows good agreement with the gold standard method of Nugent et al. and can be used as an alternative to Nugent's criteria in busy tertiary care hospitals.

Chawla R; Bhalla P; Chadha S; Grover S; Garg S

2013-01-01

18

Comparison of Hay's Criteria with Nugent's Scoring System for Diagnosis of Bacterial Vaginosis  

Science.gov (United States)

Although Nugent's criterion is considered as the gold standard for the diagnosis of bacterial vaginosis (BV), the method requires an experienced slide reader and considerable time and skill. In this study, we compared the method of Hay and Ison with Nugent's scoring criteria. Vaginal specimens were collected from a total of 213 women, presenting with or without the symptoms of vaginitis. Diagnosis of BV was done using Nugent' and Hay's method. Sensitivity, specificity, and predictive values for positive and negative test were calculated for Hay's method using Nugent's method as the gold standard. We diagnosed 70 cases (32.86%) of BV by Nugent's method and 87 (40.85%) cases by the Hay's method. Sensitivity, specificity, predictive value of positive result, predictive value of negative result, and Kappa value when evaluating Hay's criteria using Nugent's criteria as the gold standard were ?97.2%, ?88.1%, ?80.4%, ?97.1%, and ?0.830, respectively, when Hay's grade II and/or Nugent's intermediate score were considered either as negative or positive or excluded. Using Nugent score for the intermediate group is the most difficult. Hay's method shows good agreement with the gold standard method of Nugent et al. and can be used as an alternative to Nugent's criteria in busy tertiary care hospitals.

Chawla, Rohit; Chadha, Sanjim; Garg, Suneela

2013-01-01

19

Comparison of Hay's criteria with Nugent's scoring system for diagnosis of bacterial vaginosis.  

Science.gov (United States)

Although Nugent's criterion is considered as the gold standard for the diagnosis of bacterial vaginosis (BV), the method requires an experienced slide reader and considerable time and skill. In this study, we compared the method of Hay and Ison with Nugent's scoring criteria. Vaginal specimens were collected from a total of 213 women, presenting with or without the symptoms of vaginitis. Diagnosis of BV was done using Nugent' and Hay's method. Sensitivity, specificity, and predictive values for positive and negative test were calculated for Hay's method using Nugent's method as the gold standard. We diagnosed 70 cases (32.86%) of BV by Nugent's method and 87 (40.85%) cases by the Hay's method. Sensitivity, specificity, predictive value of positive result, predictive value of negative result, and Kappa value when evaluating Hay's criteria using Nugent's criteria as the gold standard were ?97.2%, ?88.1%, ?80.4%, ?97.1%, and ?0.830, respectively, when Hay's grade II and/or Nugent's intermediate score were considered either as negative or positive or excluded. Using Nugent score for the intermediate group is the most difficult. Hay's method shows good agreement with the gold standard method of Nugent et al. and can be used as an alternative to Nugent's criteria in busy tertiary care hospitals. PMID:23841066

Chawla, Rohit; Bhalla, Preena; Chadha, Sanjim; Grover, Sujatha; Garg, Suneela

2013-06-13

20

Glasgow coma score and tumor necrosis factor ? as predictive criteria for initial poor graft function.  

UK PubMed Central (United Kingdom)

Initial poor graft function (IPGF) is a major factor influencing the clinical outcome after liver transplantation (LT), but there is no reliable method to assess and predict graft dysfunction. To help clinicians determine prognosis in the early postoperative period, individual parameters and complex scoring systems have been suggested, but most of them are inaccurate because of the multifactorial nature of transplantation courses. Therefore, the aim of our study was to retrospectively evaluate predictive criteria for retransplantation. Forty-two patients were enrolled in this study: 18 who experienced primary non-function (PNF) and 24 with delayed graft function (DGF). All of the patients were treated with the Molecular Adsorbent Recirculating System (MARS). They were into 3 subgroups: patients who survived without LT (n = 20; 47.7%); patients who underwent LT (n = 16; 37%), and patients who died before transplantation (n = 6; 14%). Stepwise multivariable logistic regression analysis was performed with the intent to find the risk factors for LT or death after MARS treatment (second analysis). Receiver operating characteristic (ROC) curves were performed on significant variables in the logistic regression model with the intent to individually predict variables for LT or death. After a stepwise multivariable logistic regression analysis enrolling all of the previously reported features only 2 variables, tumor necrosis factor (TFN)-? and Glasgow coma score (GCS) score, were statistically significant. TNF-? was an unique independent risk factor for retransplantation or death after MARS treatment (odds ratio [OR] 1.235; P = .013). Conversely, GCS score was protective against retransplantation or death (OR 0.150; P = .003). Starting from these assumptions, a predictive model was created using these 2 variables. On ROC analysis, the combined score showed an area under the curve greater than that of the 2 variables considered separately. Validating these results with a larger number of patients, we considered these 2 factors as subjective parameters to determine outcomes and the difference between PNF and DGF.

Novelli G; Morabito V; Lai Q; Levi Sandri GB; Melandro F; Pugliese F; Novelli S; Rossi M; Berloco PB

2012-09-01

 
 
 
 
21

Using normalized EMG to define the nociceptive flexion reflex (NFR) threshold: further evaluation of standardized NFR scoring criteria.  

Science.gov (United States)

The nociceptive flexion reflex (NFR) has been used as a psychophysiological tool to study spinal nociceptive processes in numerous clinical and experimental studies. Despite widespread use of the NFR, few attempts have been made to empirically test and compare different scoring criteria to detect the presence/absence of the reflex. The present studies were conducted to address this issue. Study 1 (N=56 healthy participants) examined the reliability of 15 different scoring criteria that were examined in a previous report. Study 2 (N=73 healthy participants) extended this work by examining normalized scoring criteria based on biceps femoris activity unrelated to noxious stimulation (reference contraction, maximal contraction). In both studies, receiver operating characteristics (ROCs) analyses were used to evaluate and compare different scoring methods. The results indicate that a number of different criteria were acceptable for defining an NFR threshold based on the area under the ROC curve and its statistical significance; however, NFR Interval z score [(NFR Interval Mean-baseline mean)/baseline SD] emerged as the scoring criterion with the greatest accuracy and with cut-points that are reliable across samples. These findings support the application of a common NFR scoring criterion to enhance direct comparison of results across different research laboratories and study samples. PMID:19595510

France, Christopher R; Rhudy, Jamie L; McGlone, Sarah

2009-09-01

22

Using normalized EMG to define the nociceptive flexion reflex (NFR) threshold: further evaluation of standardized NFR scoring criteria.  

UK PubMed Central (United Kingdom)

The nociceptive flexion reflex (NFR) has been used as a psychophysiological tool to study spinal nociceptive processes in numerous clinical and experimental studies. Despite widespread use of the NFR, few attempts have been made to empirically test and compare different scoring criteria to detect the presence/absence of the reflex. The present studies were conducted to address this issue. Study 1 (N=56 healthy participants) examined the reliability of 15 different scoring criteria that were examined in a previous report. Study 2 (N=73 healthy participants) extended this work by examining normalized scoring criteria based on biceps femoris activity unrelated to noxious stimulation (reference contraction, maximal contraction). In both studies, receiver operating characteristics (ROCs) analyses were used to evaluate and compare different scoring methods. The results indicate that a number of different criteria were acceptable for defining an NFR threshold based on the area under the ROC curve and its statistical significance; however, NFR Interval z score [(NFR Interval Mean-baseline mean)/baseline SD] emerged as the scoring criterion with the greatest accuracy and with cut-points that are reliable across samples. These findings support the application of a common NFR scoring criterion to enhance direct comparison of results across different research laboratories and study samples.

France CR; Rhudy JL; McGlone S

2009-09-01

23

Correlation of the score for subjective pain with physical disability, clinical and radiographic scores in recent onset rheumatoid arthritis  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background To analyse the relationship between subjective pain score and other measures of clinical, radiographic and functional status; in particular Larsen radiographic scores and Health Assessment Questionnaire (HAQ); in patients with severe rheumatoid arthritis (RA) with a disease duration of less than 3 years. Methods In this cross sectional study of 105 patients with RA (76 women, 29 men: mean age 50.93; mean disease duration 15.86 months; 71% rheumatoid factor positive) subjective pain was assessed according to the Visual Analog Scale (VAS). Correlation coefficients between pain score and disease activity measures (patients' global assessment of disease by VAS, number of tender and swollen joints, morning stiffness, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP] and titre of rheumatoid factor, radiographic evaluations (Larsen-Dale scores for radiographic damage of the small joints of the hands, wrist and feet), disability measures (health assessment questionnaire [HAQ]), and demographic variables were calculated; hierarchical regression analysis was done with subjective pain score as the dependent variable. Results The Spearman's correlation coefficient comparing subjective pain and HAQ was 0.421 (p 0.05). In regression analysis, global assessment of disease by patients explained 32.8% of the variation in pain intensity score, morning stiffness 10.7%, CRP 4.0%, HAQ 3.8% and Larsen-Dale scores explained 2.1%; other variables were not significant in the model. Conclusions Pain scores of patients with early severe rheumatoid arthritis are correlated at higher levels with patients' global assessment of disease and with morning stiffness rather than with radiographic or other clinical variables such as number of tender and swollen joints.

Sarzi-Puttini Piercarlo; Fiorini Tania; Panni Benedetta; Turiel Maurizio; Cazzola Marco; Atzeni Fabiola

2002-01-01

24

Evaluation of utility in shoulder pathology: Correlating the American Shoulder and Elbow Surgeons and Constant scores to the EuroQoL  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To study whether health utility scores can be derived from shoulder-specific scores. METHODS: Authors investigated two questions: (1) do the American Shoulder and Elbow Surgeons (ASES) score and the Constant score correlate with the EuroQoL (EQ-5D), a measure of health utility? (2) can the ASES and Constant scores be obtained from a complete study sample without bias? Thirty subjects with various shoulder diagnoses completed ASES, Constant, and EQ-5D instruments. Pearson correlations were calculated to assess the associations between EQ-5D score and ASES and Constant scores. RESULTS: The correlation between EQ-5D score and ASES score was 0.60 (P < 0.001); it was 0.54 for EQ-5D and Constant scores (P < 0.003). A multiple regression model containing ASES score, Constant score, age, and gender failed to adequately predict EQ-5D. Moreover, 25% of patients meeting the inclusion criteria did not complete the ASES questionnaire because they did not feel that specific questions, such as “do usual sport - list” and “throw ball overhand,” applied to them. CONCLUSION: Authors’ results do not support the use of the ASES and Constant scores in predicting EuroQol health utility values. However, the Constant score was more suitable for this patient population because all patients were able to complete it.

Blaine T Bafus; Richard E Hughes; Bruce S Miller; James E Carpenter

2012-01-01

25

The Correlational Relationship between Homeschooling Demographics and High Test Scores.  

Science.gov (United States)

Homeschooling, one of the fastest growing educational alternatives, is enjoying increasing respect from educators and parents alike. This is partly because homeschooling children score as well and often better on standardized tests than their publicly schooled counterparts. However, the vast majority of homeschooled students come from the…

Burns, Johnna

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Correlation between body fat components and coronary heart disease risk scores  

Directory of Open Access Journals (Sweden)

Full Text Available ABSTRACTIntroductionThough body fat is well known risk factor for coronary heart disease, it is not known whether components of body fat can be considered equivalent to coronary heart disease prediction scores in predicting future risk of coronary heart disease.AIMTo test correlation between coronary heart disease risk scores and components of body fat.Material and methodsThe study subjects were evaluated clinically. Anthropometric data were obtained. Serum fasting lipid profile was tested. Body fat and components were tested by Omron karada scan. Framingham score, PROCAM score and Vascular age were calculated. Correlation between coronary heart disease risk scores with subcutaneous tissue fat, visceral fat, total body fat, WHR and BMI was tested by Pearsons correlation.Results and Data AnalysisOur study included 103 patients. 44.7% study subjects were diabetic. 35% of the male patients were smokers. Framingham Risk score was significantly higher in males (p value 0.0000). BMI, Total body fat percentage, tissue fat and visceral fat levels were not found to correlate with coronary heart disease risk scores. Regression analysis showed visceral fat as the strongest correlate of each of the coronary heart disease risk scores, and WHR was the next most significant independent predictor of these outcomes.ConclusionWaist Hip Ratio (WHR), visceral fat are best correlates of coronary heart disease risk scores and can be considered as surrogates of coronary heart disease risk prediction scores in clinical practice.

Ram S Kaulgud; Guruprasad V Deshpande; Vasantha Kamath; Rajeev R Joshi; Mallikarjuna Swamy; Vijayalakshmi P B

2013-01-01

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Correlation of the bottom turn technique with the scores attributed in high performance surfing.  

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Full Text Available The surf contests worldwide have presented a high and homogeneous level of performance by the athletes. Thus, the hypothesis that the bottom turn (BT), curve on the base of the wave which is essential to the construction of subsequent maneuvers, might influence the results in high performance competitions. The objective of this study was to quantify the time taken in the execution of the BT by the athletes and correlate it to the scores awarded. The research sample was composed of four contests of the Surfing World Tour. Four heats of each contest were assessed, in a total of sixteen heats studied. The analysis of each BT was performed by using the video split feature available in the Sony Vegas Pro 10.0 software. The statistic analysis was performed with the software SPSS 18.0. The Pearson correlation coefficient was calculated with a significance level of p<0.01. According to the correlations, there was an association between the variables for 87.5% of the cases. Results show that the increase of the curve in the base of the wave (BT) can maximize the performance potential of the surfers, suggesting that BT is a fundamental technical aspect in the construction of subsequent maneuvers that suit the judging criteria of this category.

Pedro Caetano Souza; Marcos Augusto Rocha; Juarez Vieira Nascimento; Pedro Caetano Souza; Marcos Augusto Rocha; Juarez Vieira Nascimento

2012-01-01

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Chronic obstructive pulmonary disease assessment test score correlated with dyspnea score in a large sample of Chinese patients.  

UK PubMed Central (United Kingdom)

BACKGROUND: The chronic obstructive pulmonary disease assessment test (CAT) is an easy to use health-related quality of life questionnaire, the modified Medical Research Council (mMRC) dyspnea scale is a classic dyspnea scale which is widely used, while the correlation between them is still not clear. This study investigated the use of the Chinese translation of CAT in chronic obstructive pulmonary disease patients and its correlation with the mMRC dyspnea scale. METHODS: The multicenter cross-sectional study was conducted in 329 hospitals throughout China from March 1 to April 30, 2010. Chronic obstructive pulmonary disease patients completed both the assessment test and the dyspnea scale during a single study visit. RESULTS: Six thousand, four hundred and thirty-seven patients were evaluated; 74.9% were male and the mean age was (64.9 ± 10.0) years. Median test scores in dyspnea grades 0 to 4 were 14, 16, 22, 26 and 32, respectively; these differences were statistically significant. The CAT score was moderately correlated with mMRC dyspnea grade (r = 0.579, P < 0.001). There was no significant difference in mean CAT score between males and females, and patients of high and low socioeconomic status. Primary analysis suggested that CAT scores were higher in older patients (>65 years) than in younger patients (? 65 years) and increased with duration of formal education, but these findings were repudiated by further analysis of subgroups according to mMRC dyspnea grade. CONCLUSIONS: There was no obvious confounding factor influencing use of the CAT in Chinese patients. CAT scores were moderately correlated with the mMRC dyspnea scale.

Zhou QT; Mei JJ; He B; Huang SG; Shi Y; Wen FQ; Zhao MW

2013-01-01

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Anomalous diffusion and long-range correlations in the score evolution of the game of cricket  

Science.gov (United States)

We investigate the time evolution of the scores of the second most popular sport in the world: the game of cricket. By analyzing, event by event, the scores of more than 2000 matches, we point out that the score dynamics is an anomalous diffusive process. Our analysis reveals that the variance of the process is described by a power-law dependence with a superdiffusive exponent, that the scores are statistically self-similar following a universal Gaussian distribution, and that there are long-range correlations in the score evolution. We employ a generalized Langevin equation with a power-law correlated noise that describes all the empirical findings very well. These observations suggest that competition among agents may be a mechanism leading to anomalous diffusion and long-range correlation.

Ribeiro, Haroldo V.; Mukherjee, Satyam; Zeng, Xiao Han T.

2012-08-01

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Anomalous diffusion and long-range correlations in the score evolution of the game of cricket.  

UK PubMed Central (United Kingdom)

We investigate the time evolution of the scores of the second most popular sport in the world: the game of cricket. By analyzing, event by event, the scores of more than 2000 matches, we point out that the score dynamics is an anomalous diffusive process. Our analysis reveals that the variance of the process is described by a power-law dependence with a superdiffusive exponent, that the scores are statistically self-similar following a universal Gaussian distribution, and that there are long-range correlations in the score evolution. We employ a generalized Langevin equation with a power-law correlated noise that describes all the empirical findings very well. These observations suggest that competition among agents may be a mechanism leading to anomalous diffusion and long-range correlation.

Ribeiro HV; Mukherjee S; Zeng XH

2012-08-01

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Heritabilities and correlations among body condition score, dairy form and selected linear type traits.  

Science.gov (United States)

The objectives of this study were to estimate the heritability of body condition score (BCS) with data that could be used to generate genetic evaluations for BCS in the US, and to estimate the relationship among BCS, dairy form and selected type traits. Body condition score and linear type trait records were obtained from Holstein Association USA Inc. Because BCS was a new trait for classifiers, scoring distribution and accuracy was not normal. Records from 11 of 29 classifiers were eliminated to generate a data set that should represent BCS data recorded in the future. Edited data included 128,478 records for analysis of first lactation cows and 207,149 records for analysis of all cows. Heritabilities and correlations were estimated with ASREML using sire models. Models included age at calving nested within lactation, 5th order polynomials of DIM, fixed herd-classification visit effects and random sire and error. Genetic correlation estimates were generated between first lactation data that had records from 11 classifiers removed and data with no classifiers removed. Genetic correlation estimates were 0.995 and above between data with and without classifiers removed for scoring distributions, but heritability estimates were higher with the classifiers edited from the data. Heritability estimates for type traits and final score were similar to previously reported estimates. The heritability estimate for BCS was 0.19 for first lactation cows and 0.22 for all cows. The genetic correlation estimate for first lactation cows between BCS and dairy form was -0.73, whereas the genetic correlation estimate between BCS and strength was 0.72. Genetic correlation estimates were nearly identical when cows from all lactations were included in the analyses. Body condition score had a genetic correlation with final score closer to zero (0.08) than correlations of final score with dairy form, stature or strength. PMID:12836961

Dechow, C D; Rogers, G W; Klei, L; Lawlor, T J

2003-06-01

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Heritabilities and correlations among body condition score, dairy form and selected linear type traits.  

UK PubMed Central (United Kingdom)

The objectives of this study were to estimate the heritability of body condition score (BCS) with data that could be used to generate genetic evaluations for BCS in the US, and to estimate the relationship among BCS, dairy form and selected type traits. Body condition score and linear type trait records were obtained from Holstein Association USA Inc. Because BCS was a new trait for classifiers, scoring distribution and accuracy was not normal. Records from 11 of 29 classifiers were eliminated to generate a data set that should represent BCS data recorded in the future. Edited data included 128,478 records for analysis of first lactation cows and 207,149 records for analysis of all cows. Heritabilities and correlations were estimated with ASREML using sire models. Models included age at calving nested within lactation, 5th order polynomials of DIM, fixed herd-classification visit effects and random sire and error. Genetic correlation estimates were generated between first lactation data that had records from 11 classifiers removed and data with no classifiers removed. Genetic correlation estimates were 0.995 and above between data with and without classifiers removed for scoring distributions, but heritability estimates were higher with the classifiers edited from the data. Heritability estimates for type traits and final score were similar to previously reported estimates. The heritability estimate for BCS was 0.19 for first lactation cows and 0.22 for all cows. The genetic correlation estimate for first lactation cows between BCS and dairy form was -0.73, whereas the genetic correlation estimate between BCS and strength was 0.72. Genetic correlation estimates were nearly identical when cows from all lactations were included in the analyses. Body condition score had a genetic correlation with final score closer to zero (0.08) than correlations of final score with dairy form, stature or strength.

Dechow CD; Rogers GW; Klei L; Lawlor TJ

2003-06-01

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The simplified SART embryo scoring system is highly correlated to implantation and live birth in single blastocyst transfers.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Prior studies have validated the ability of the SART embryo scoring system to correlate with outcomes in cleavage stage embryo transfers. However, this scoring system has not been evaluated in blastocyst transfers. The objective of this study was to estimate the correlation between the simplified SART embryo scoring system and ART cycle outcomes in single blastocyst transfers. MATERIALS AND METHODS: All fresh, autologous single blastocyst transfers cycles from a large ART center from 2010 were analyzed. Blastocysts were given a single grade of good, fair, or poor based upon SART criteria which combines the grading of the inner cell mass and trophectoderm. Multiple logistic regression assessed the predictive value of the SART grade on embryo implantation and live birth. RESULTS: Seven hundred seventeen fresh, autologous single blastocyst transfers cycles were included in the analysis. The live birth rate was 52 % and included both elective and non-elective SBT. Chi square analysis showed higher live birth in good grade embryos as compared to fair (p=0.03) and poor (p=0.02). Univariate binary logistic regression analysis demonstrated SART embryo grading to be significantly correlated with both implantation and live birth (p<0.01). This significance persisted when patient age, BMI, and the stage of the blastocyst were controlled for with multiple logistic regression. In five patients with a poor blastocyst score, there were no live births. CONCLUSION: These data demonstrate that the SART embryo scoring system is highly correlated to implantation and live birth in single blastocyst transfers. Patients with a good grade embryo are excellent candidates for a single blastocyst transfer.

Heitmann RJ; Hill MJ; Richter KS; DeCherney AH; Widra EA

2013-04-01

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Characterization of REM sleep without atonia in patients with narcolepsy and idiopathic hypersomnia using AASM scoring manual criteria.  

UK PubMed Central (United Kingdom)

INTRODUCTION: The AASM Manual for the Scoring of Sleep and Associated Events (Manual) has provided standardized definitions for tonic and phasic REM sleep without atonia (RSWA). This study used Manual criteria to characterize REM sleep in patients with narcolepsy and idiopathic hypersomnia (IH). METHODS: A retrospective review of PSG data from ICSD-2 defined patients with narcolepsy or IH, performed by two board certified sleep medicine physicians. Data compiled included REM sleep epochs and the presence in REM sleep of epochs scored as sustained muscle activity (tonic), and excessive transient muscle activity (phasic) as defined by Manual criteria. RESULTS: PSG data from 8 narcolepsy patients (mean age: 27.5 years; age range: 11-55) showed mean ± standard deviation values for: total REM sleep epochs 205 ± 46.1; RSWA/ phasic epochs 56.1 ± 25.4; and RSWA/tonic epochs 15.0 ± 10.7. PSG data from 8 IH patients (mean age: 33.1 years; age range: 20-57) showed mean ± standard deviation values of total REM sleep epochs 163.8 ± 67.9; RSWA/phasic epochs 6.2 ± 3.5; and RSWA/tonic epochs 0.2 ± 0.4. Comparison revealed intergroup differences in phasic REM sleep (p < 0.01) and tonic REM sleep (p < 0.01) were significantly increased in narcoleptics compared to IH. CONCLUSION: Our retrospective analysis showed that RSWA phasic activity and RSWA tonic activity are significantly increased in patients meeting ICSD-2 criteria for narcolepsy compared to patients meeting ICSD-2 criteria for IH. This robust difference, with further validation, could be useful as electrophysiological criteria differentiating the two disorders and understanding the physiological differences.

DelRosso LM; Chesson AL Jr; Hoque R

2013-07-01

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High resolution CT in children with cystic fibrosis: correlation with pulmonary functions and radiographic scores  

Energy Technology Data Exchange (ETDEWEB)

Objective: To compare the high resolution CT (HRCT) scores of the Bhalla system with pulmonary function tests and radiographic and clinical points of the Shwachman-Kulczycki clinical scoring system. Methods: HRCT of the chest was obtained in 40 children to assess the role of HRCT in evaluating bronchopulmonary pathology in children with cystic fibrosis (CF). The HRCT severity scores of the Bhalla system were compared with chest radiographic and clinical points of the Shwachman-Kulczycki scoring system and pulmonary function tests. Only 14 of the patients older than 6 years cooperated with spirometry. Results: HRCT scores correlated well with radiographic points (r=0.80, P<0.0001) and clinical points (r=0.67, P<0.0001) of the Shwachman-Kulczycki system, FVC (r=0.71 P=0.004) and FEV{sub 1} (r=0.66, P=0.01). Although radiographic points correlated significantly with FVC (r=0.61, P=0.02) and FEV{sub 1} (r=0.56, P=0.04), HRCT provides a more precise scoring than the chest X-ray. Conclusion: The HRCT scoring system may provide a sensitive method of monitoring pulmonary disease status and may replace the radiographic scoring in the Shwachman-Kulczycki system. It may be helpful especially in follow-up of small children too young to cooperate with spirometry.

Demirkazik, Figen Basaran E-mail: demirkaz@dialup.ankara.edu.tr; Ariyuerek, O. Macit; Oezcelik, Ugur; Goecmen, Ayhan; Hassanabad, Hossein K.; Kiper, Nural

2001-01-01

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THE INFLUENCE OF PRIOR EXPERIENCE ON THE CONSTRUCTION OF SCORING CRITERIA FOR ESL COMPOSITIONS: A CASE STUDY  

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Full Text Available Before a principled explanation of variability in raters' judgements of ESL compositions can be offered, the process of constructing scoring criteria and the manner in which prior experience enters this process must be analyzed. Therefore, utilizing protocol and intewiew data collected in the context of a comparative study, a case study will describe how one experienced rater dealt with the following operations while assessing a corpus of 60 TOEFL essays: establishing the purpose of assessment, developing a reading strategy to deal with a corpus of essays, and collecting context-specific information. Within each operation, the influence of background variables such as teaching and assessment experience will be examined, particularly on determining what type of information to collect, and on articulating expectations concerning test takers, test scores and the textual qualities of essays. The results of the study will be used to specific directions for future research into explaining inter-rater variability.

M. Usman Erdosy

2001-01-01

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The Hammersmith functional score correlates with the SMN2 copy number: a multicentric study.  

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Previous studies showed that SMN2 copy number correlates inversely with the disease severity. Our aim was to evaluate SMN2 copy numbers and the Hammersmith functional motor scale in 87 patients with SMA II in order to establish whether, within SMAII, the number of copies correlates with the severity of functional impairment. Our results showed a relative variability of functional scores, but a significant correlation between the number of SMN2 genes and the level of function. PMID:17433677

Tiziano, F D; Bertini, E; Messina, S; Angelozzi, C; Pane, M; D'Amico, A; Alfieri, P; Fiori, S; Battini, R; Berardinelli, A; Boffi, P; Bruno, C; Cini, C; Minetti, C; Mongini, T; Morandi, L; Orcesi, S; Pelliccioni, M; Pini, A; Villanova, M; Vita, G; Locatelli, M; Mercuri, E; Brahe, C

2007-04-12

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Multivariate injury risk criteria and injury probability scores for fractures to the distal radius.  

Science.gov (United States)

The purpose of this study was to develop a multivariate distal radius injury risk prediction model that incorporates dynamic loading variables in multiple directions, and interpret the distal radius failure data in order to establish injury probability thresholds. Repeated impacts with increasing intensity were applied to the distal third of eight human cadaveric radius specimens (mean (SD) age=61.9 (9.7)) until injury occurred. Crack (non-propagating damage) and fracture (specimen separated into at least two fragments) injury events were recorded. Best subsets analysis was performed to find the best multivariate injury risk model. Force-only risk models were also determined for comparison. Cumulative distribution functions were developed from the parameters of a Weibull analysis and the forces and risk scores (i.e., values calculated from the injury risk models) from 10% to 90% probability were calculated. According to the adjusted R(2), variance inflation factor and p-values, the model that best predicted the crack event included medial/lateral impulse, Fz load rate, impact velocity and the natural logarithm of Fz (Adj. R(2)=0.698), while the best predictive model of the fracture event included medial/lateral impulse, impact velocity and peak Fz (Adj. R(2)=0.845). The multivariate models predicted injury risk better than both the Fz-only crack (Adj. R(2)=0.551) and fracture (Adj. R(2)=0.293) models. Risk scores of 0.5 and 0.6 corresponded to 10% failure probability for the crack and fracture events, respectively. The inclusion of medial/lateral impulse and impact velocity in both crack and fracture models, and Fz load rate in the crack model, underscores the dynamic nature of these events. This study presents a method capable of developing a set of distal radius fracture prediction models that can be used in the assessment and development of distal radius injury prevention interventions. PMID:23352774

Burkhart, Timothy A; Andrews, David M; Dunning, Cynthia E

2013-01-23

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Multivariate injury risk criteria and injury probability scores for fractures to the distal radius.  

UK PubMed Central (United Kingdom)

The purpose of this study was to develop a multivariate distal radius injury risk prediction model that incorporates dynamic loading variables in multiple directions, and interpret the distal radius failure data in order to establish injury probability thresholds. Repeated impacts with increasing intensity were applied to the distal third of eight human cadaveric radius specimens (mean (SD) age=61.9 (9.7)) until injury occurred. Crack (non-propagating damage) and fracture (specimen separated into at least two fragments) injury events were recorded. Best subsets analysis was performed to find the best multivariate injury risk model. Force-only risk models were also determined for comparison. Cumulative distribution functions were developed from the parameters of a Weibull analysis and the forces and risk scores (i.e., values calculated from the injury risk models) from 10% to 90% probability were calculated. According to the adjusted R(2), variance inflation factor and p-values, the model that best predicted the crack event included medial/lateral impulse, Fz load rate, impact velocity and the natural logarithm of Fz (Adj. R(2)=0.698), while the best predictive model of the fracture event included medial/lateral impulse, impact velocity and peak Fz (Adj. R(2)=0.845). The multivariate models predicted injury risk better than both the Fz-only crack (Adj. R(2)=0.551) and fracture (Adj. R(2)=0.293) models. Risk scores of 0.5 and 0.6 corresponded to 10% failure probability for the crack and fracture events, respectively. The inclusion of medial/lateral impulse and impact velocity in both crack and fracture models, and Fz load rate in the crack model, underscores the dynamic nature of these events. This study presents a method capable of developing a set of distal radius fracture prediction models that can be used in the assessment and development of distal radius injury prevention interventions.

Burkhart TA; Andrews DM; Dunning CE

2013-03-01

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Comparison of radiofrequency ablation and transarterial chemoembolization for hepatocellular carcinoma within the Milan criteria: a propensity score analysis.  

Science.gov (United States)

Radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) are used to treat hepatocellular carcinoma (HCC). This study was designed to compare the long-term survival of HCC patients within the Milan criteria who underwent RFA or TACE. In all, 315 RFA patients and 215 TACE patients with HCC within the Milan criteria were analyzed. Propensity scores were generated to select matched patients. For the propensity model, 101 patients were selected from each arm of the study. Independent prognostic predictors were determined with the Cox proportional hazards model. The long-term survival was significantly better for the RFA group in the univariate survival analysis (P = 0.048). In the Cox model, the following were identified as independent predictors of poor prognosis (TACE was not): age > 69 years (P = 0.026), serum ?-fetoprotein level > 20 ng/mL (P = 0.003), ascites (P TTV) > 8.2 cm³ (P = 0.020), and vascular invasion (P = 0.023). With similar baseline patient characteristics generated in the propensity score model, there was no significant difference in the long-term survival rates of the 2 groups of patients. A subgroup analysis showed that among patients with a TTV TTV (<11 cm³) are likely to benefit more from RFA treatment. Further studies are needed to compare RFA and TACE in patients with early-stage cancers. PMID:21506244

Hsu, Chia-Yang; Huang, Yi-Hsiang; Chiou, Yi-You; Su, Chien-Wei; Lin, Han-Chieh; Lee, Rheun-Chuan; Chiang, Jen-Huey; Huo, Teh-Ia; Lee, Fa-Yauh; Lee, Shou-Dong

2011-05-01

 
 
 
 
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Comparison of radiofrequency ablation and transarterial chemoembolization for hepatocellular carcinoma within the Milan criteria: a propensity score analysis.  

UK PubMed Central (United Kingdom)

Radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) are used to treat hepatocellular carcinoma (HCC). This study was designed to compare the long-term survival of HCC patients within the Milan criteria who underwent RFA or TACE. In all, 315 RFA patients and 215 TACE patients with HCC within the Milan criteria were analyzed. Propensity scores were generated to select matched patients. For the propensity model, 101 patients were selected from each arm of the study. Independent prognostic predictors were determined with the Cox proportional hazards model. The long-term survival was significantly better for the RFA group in the univariate survival analysis (P = 0.048). In the Cox model, the following were identified as independent predictors of poor prognosis (TACE was not): age > 69 years (P = 0.026), serum ?-fetoprotein level > 20 ng/mL (P = 0.003), ascites (P < 0.001), Eastern Cooperative Oncology Group performance status ? 1 (P = 0.004), total tumor volume (TTV) > 8.2 cm³ (P = 0.020), and vascular invasion (P = 0.023). With similar baseline patient characteristics generated in the propensity score model, there was no significant difference in the long-term survival rates of the 2 groups of patients. A subgroup analysis showed that among patients with a TTV < 11 cm³, the RFA group had significantly better long-term survival than the TACE group (P = 0.032). In conclusion, TACE and RFA lead to comparable long-term survival rates for HCC patients within the Milan criteria. Patients with a smaller TTV (<11 cm³) are likely to benefit more from RFA treatment. Further studies are needed to compare RFA and TACE in patients with early-stage cancers.

Hsu CY; Huang YH; Chiou YY; Su CW; Lin HC; Lee RC; Chiang JH; Huo TI; Lee FY; Lee SD

2011-05-01

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Could Epicardial Adipose Tissue Thickness by Echocardiography Be Correlated with Acute Coronary Syndrome Risk Scores.  

UK PubMed Central (United Kingdom)

AIM: The aim of our study was, echocardiographic epicardial adipose tissue (EAT) thickness could show the severity and the prognosis of acute coronary syndromes (ACS). METHODS AND RESULTS: Sixty-five ACS patients (mean age 57.4 ± 12.2 years) who underwent coronary angiography were studied. EAT thickness on the free wall of right ventricle was measured at end-diastole from the parasternal long-axis views of 3 cardiac cycles. SYNTAX and Global Registry of Acute Coronary Events (GRACE) scoring considered for severity and the prognosis of ACS. The mean value of the EAT thickness were 5.5 ± 0.5 mm (range 1-12 mm). EAT thickness had a positive correlation with high sensitive troponin T (r = 0.712, P < 0.001) and body mass index (r = 0.522, P < 0.001.) EAT thickness was significantly correlated patients with high SYNTAX score (r = 0.690, P < 0.001), but not correlated with GRACE score (r = 0.224, P = 0.072). CONCLUSION: Epicardial adipose tissue thickness was correlated with angiographic severity of ACS, but not correlated with clinical prognosis risk score.

Altun B; Colkesen Y; Gazi E; Tasolar H; Temiz A; Simsek HY; Barutcu A; Gungor O; Kirilmaz B; Ceyhan K

2013-07-01

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Evaluating the correlation between the HUESAD and OSATS scores: concurrent validity study.  

UK PubMed Central (United Kingdom)

BACKGROUND: The aim of this study was to determine whether a correlation exists between the HUESAD and both the OSATS checklist and the global rating score. MATERIAL AND METHODS: Fourteen participants were recruited, ranging from residents to consultants. The HUESAD measured three different parameters: Visual spatial ability, smoothness and accuracy. The OSTAS measured the endoscopic surgical skills by the checklist and the global rating score. RESULTS: A significant relationship was thus identified between the OSATS checklist (p < 0.0001), the OSATS global rating score (p < 0.05) and the HUESAD assessment in the evaluation of visual-spatial ability. In terms of smoothness, there was also a significant relationship between the OSATS checklist (p < 0.05), the OSATS global rating score (p < 0.05) and the HUESAD assessment. Moreover, there was a significant relationship between the OSATS checklist (p < 0.05), the OSATS global rating score (p < 0.05) and the HUESAD assessment for accuracy. CONCLUSIONS: There was strong correlation between the motion analysis in the HUESAD assessment and OSATS checklist and the global rating score. Moreover, the visual spatial ability, smoothness and accuracy analyzed by the HUESAD were reliable parameters when assessing the endoscopic surgical skills.

Egi H; Tokunaga M; Hattori M; Ohdan H

2013-06-01

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HRCT score in bronchiectasis: Correlation with pulmonary function tests and pulmonary artery pressure  

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Full Text Available Background: High resolution CT scan (HRCT) and its score have an important role in delineating pathological changes and pulmonary functional impairment in patients with bronchiectasis. Aims: To assess pulmonary function tests (PFTs) in patients with cystic and cylindrical bronchiectasis. To correlate HRCT score with PFTs and systolic pulmonary artery pressure (SPAP) in both radiological types. Materials and Methods: A cross-sectional study of patients with bronchiectasis diagnosed by HRCT was conducted at King Khalid University Hospital, Riyadh, Saudi Arabia. PFTs, HRCT score and SPAP were measured in both types. Results: We studied 94 patients with bronchiectasis: 62 were cystic and 32 were cylindrical. Their mean age was 53.4±17.5 SD years. Forced vital capacity (FVC %) and forced expiratory volume in 1 second (FEV1%) were significantly lower in cystic patients ( P p P P =0.002)and correlated with SPAP ( r =0.23). Global HTCT score of 10.3±2.5 was associated with SPAP ?40mmHg( P =0.011). Conclusion: Patients with cystic bronchiectasis have significant impairment of pulmonary physiology compared with cylindrical bronchiectasis patients. HRCT score correlated with PFTs and SPAP.

Alzeer Abdulaziz

2008-01-01

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Resected biliary tract cancers: a novel clinical-pathological score correlates with global outcome.  

UK PubMed Central (United Kingdom)

BACKGROUND: Biliary tract cancer presents a poor prognosis. AIMS: The objective of this study is to find clinical-laboratory parameters like prognostic factors to select patients who can benefit from surgery and post-operative treatments. METHODS: Between 2005 and 2010, 41 patients underwent radical surgery at our Institution. A novel score was retrospectively calculated assigning a grade to the clinical-laboratory findings at diagnosis. 0 and 1 point were respectively assigned to the normal or abnormal parameter. Two groups were identified: SCORE 0 and SCORE 1. RESULTS: Patients with cholangiocarcinoma or Klatskin tumours or asymptomatic at diagnosis presented a significantly better overall survival (OS) than patients with different primary sites or who presented pain, jaundice or cholangitis. At univariate analysis, high levels of aspartate aminotransferase, alanine aminotransferase and CA19-9 before surgery, hyperbilirubinemia before and after surgery had a negative correlation with OS. A worse OS was observed in patients with a higher score (median OS in the "score 0" group=30.79 months vs. median OS in the "score 1"=17.98 months). CONCLUSION: Our results suggest that pre and post-surgery clinical-laboratory parameters and the novel score, could be useful, especially for intrahepatic tumours, in predicting the outcome in patients undergoing surgery and in selecting patients to receive adjuvant therapy.

Berardi R; Mocchegiani F; Pierantoni C; Federici A; Nicolini D; Morgese F; Onofri A; Risaliti A; Vivarelli M; Cascinu S

2013-01-01

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Correlation between international prostate symptoms score and uroflowmetry finding in men with lower urinary tract symptoms  

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Full Text Available Background and Objectives: Benign prostatic hyperplasia (BPH) is a common age-related urological disorder. Patients can subjectively descript their micturition habits by using the international prostate symptom score (IPSS) but whether or not patients answer correlate with their uroflowmetic findings has not been validated objectively. The aim of this study was to evaluate the correlation of patient answers with findings on uroflowmetry studies.Subjects and Methods: eighty six patients with lower urinary tract symptoms (LUTS) were evaluated by IPSS and uroflowmetry. IPSS was divided into voiding and storage symptoms. Waiting time, voided volume, maximum and average flow rates were recorded. The relationship between these parameters was quantified by SPSS software Pearson correlation coefficient. Results: Patients were aged 46 - 79 years old. Age did not correlate by Qmax , Qave , IPSS and voided volume. Voided volumes were 109-647ml (mean=259.5 ml). Qmax was <15ml/s in about 63% of patients (54 patients) independently of age. Qmax was correlated negatively with total IPSS score and voiding symptoms but did not correlate with storage symptoms. Qave correlated only with voiding symptoms(p=0.04) but not with total IPSS and storage symptoms. Waiting time did not correlate with total IPSS, voiding and storage symptoms. Conclusion: There is a close correlation between IPSS and uroflowmetry results.uroflowmetry is a more suitable for LUTS paitents who have improper understanding the IPSS questions due to cultural or language problems. Sci Med J 2011; 10(2):205-213

Kheradmand A; Hosaini M; Babaali N

2011-01-01

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Correlation of Stress During Pregnancy with Apgar Scores and Physical Conditions of Neonates  

Directory of Open Access Journals (Sweden)

Full Text Available AbstractObjectives: This project aimed to evaluate the correlation between mothers’ mental stress during pregnancy with birth effects. Method:The subjects were 100 mothers (pregnant women from the city of Isfahan) and their newborns selected through random cluster multistage sampling.The correlation of the mothers’ mental stress during pregnancy was assessed with the newborns’ weight and height,Apgar scores at one and five minutes, size of the babies’ head circumferences, and the length of pregnancy obtained by Mater-nal Stress During Pregnancy and its Resources Questionnaire. Data related to birth effects were collected by Apgar Rating Scale and medical records of the mothers and their newborns. Multivari- ate analysis of variance (MANOVA) and Pearson correlation coefficient were used for statistical ana- lysis of data. Findings: There is a significant correlation between mothers’ mental stress during pregnancy with newborns’ weight and height,Apgar’s score at one minute, size of the babies’ head circumferences, and the length of pregnancy.No significant correlation was obtained between mothers’ mental stress during pregnancy with Apgar’s score at five minute. Results: Mothers’ mental stress during pregnancy is correlated with birth effects.

H. Molavi; M. Movahedi; M. Bengar

2004-01-01

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New Perspectives on the Correlation of SAT Scores, High School Grades, and Socioeconomic Factors  

Science.gov (United States)

In studies of the SAT, correlations of SAT scores, high school grades, and socioeconomic factors (SES) are usually obtained using a university as the unit of analysis. This approach obscures an important structural aspect of the data: The high school grades received by a given institution come from a large number of high schools, all of which have…

Zwick, Rebecca; Greif Green, Jennifer

2007-01-01

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Correlation of basal ganglia magnetic resonance spectroscopy with Apgar score in perinatal asphyxia.  

UK PubMed Central (United Kingdom)

BACKGROUND: Brain metabolite levels are measured by proton magnetic resonance spectroscopy (1H MRS) and include N-acetylaspartate (NAA), creatine (Cr), choline (Cho), and lactate and the ratios NAA to Cho and Cr (NAA-ChoCr), NAA-Cr, NAA-Cho, and Cho-Cr. Brain metabolite levels may correlate with the degree of neonatal asphyxia. OBJECTIVE: To determine which brain metabolite ratios have the strongest correlation with the Apgar scores in infants with possible asphyxia; whether the correlation is stronger with basal ganglia (BG) or anterior border-zone metabolites; and whether a combined approach using routine MR imaging (MRI), diffusion-weighted MRI, and MRS can be used to evaluate the severity of neonatal asphyxia. METHODS: Twenty infants with 1-minute Apgar scores of 6 or less were studied at 2 to 28 days of age. The MRS variables were compared with routine and diffusion-weighted brain MRI. Clinical variables and MRS findings were subjected to factor analysis and stepwise multiple regressions to determine interrelationships. RESULTS: The BG region NAA-Cho and NAA-ChoCr ratios correlated with the 1-minute (P<.001) and 5-minute (P = .01 for NAA-Cho; P = .006 for NAA-ChoCr). There was no correlation between metabolite levels and the 10-minute Apgar scores. The stongest predictions exist between the 1-minute Apgar scores and the NAA-Cho and NAA-ChoCr ratios. In the anterior border zone, the only correlation was between the 1-minute Apgar score and the NAA-Cho ratio, but there was a strong age effect in these data. Lactate was found in the BG of 3 infants, all of whom had 5-minute Apgar scores of 6 or less. Three patients had focal lesions on MRI; 2 of these had elevated lactate levels in the abnormal region; and the third, who had an intrauterine stroke, had no lactate in the region. CONCLUSIONS: Correlations between NAA-Cho and NAA-ChoCr ratios and the 1- and 5-minute Apgar scores are stronger in the BG region than in the frontal border zone. The presence or absence of lactate may indicate the severity of the brain insult, and the combination of MRS, MRI, and diffusion-weighted MRI may assist in localizing and predicting a long-term brain injury.

Pavlakis SG; Kingsley PB; Harper R; Buckwald S; Spinazzola R; Frank Y; Prohovnik I

1999-12-01

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Enzian classification: does it correlate with clinical symptoms and the rASRM score?  

UK PubMed Central (United Kingdom)

OBJECTIVE: To assess the extent to which the Enzian classification correlates with the revised American Society for Reproductive Medicine (rASRM) score and clinical symptoms in women with deeply infiltrating endometriosis. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: Endometriosis competence center specializing in minimally invasive surgery. PATIENTS: Between 1 January 2009 and 31 December 2011, a total of 194 women underwent surgery due to deeply infiltrating endometriosis. After histological confirmation, they were classified using the rASRM and Enzian systems. Clinical symptoms were recorded preoperatively. INTERVENTIONS: Operative laparoscopy to treat endometriosis. MAIN OUTCOME MEASURES AND RESULTS: A clear correlation was seen between grades of severity in the rASRM score and the Enzian classification (p < 0.001). In addition, the rASRM severity grade and clinical symptoms correlated with the locations in the Enzian classification in relation to deeply infiltrating endometriosis. Pain and dysmenorrhea correlated strongly (p = 0.002, p < 0.001) with the severity grade in the Enzian classification. CONCLUSIONS: Deeply infiltrating endometriosis is well characterized using the Enzian classification as a supplement to the rASRM score. There is also a clear correlation between the rASRM and Enzian classifications, because of the way in which the disease crosses morphological boundaries. The locations in the Enzian classification correlate partially with clinical symptoms, and the classification's severity grades correlate substantially with pain and dysmenorrhea. In view of these clinical results, use of the Enzian classification can be recommended as a supplement to the rASRM score for detailed description of endometriosis.

Haas D; Oppelt P; Shebl O; Shamiyeh A; Schimetta W; Mayer R

2013-05-01

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Nociception Coma Scale-Revised Scores Correlate With Metabolism in the Anterior Cingulate Cortex.  

UK PubMed Central (United Kingdom)

BACKGROUND: . The Nociception Coma Scale-Revised (NCS-R) was recently validated to assess possible pain perception in patients with disorders of consciousness. OBJECTIVE: . To identify correlations between cerebral glucose metabolism and NCS-R total scores. METHODS: . [18F]-fluorodeoxyglucose positron emission tomography, NCS-R, and Coma Recovery Scale-Revised assessments were performed in 49 patients with disorders of consciousness. RESULTS: . We identified a significant positive correlation between NCS-R total scores and metabolism in the posterior part of the anterior cingulate cortex, known to be involved in pain processing. No other cluster reached significance. No significant effect of clinical diagnosis (vegetative/unresponsive vs minimally conscious states), etiology or interval since insult was observed. CONCLUSIONS: . Our data support the hypothesis that the NCS-R total scores are related to cortical processing of nociception and may constitute an appropriate behavioral tool to assess, monitor, and treat possible pain in brain-damaged noncommunicative patients with disorders of consciousness. Future studies using event-related functional magnetic resonance imaging should investigate the correlation between NCS-R scores and brain activation in response to noxious stimulation at the single-subject level.

Chatelle C; Thibaut A; Bruno MA; Boly M; Bernard C; Hustinx R; Schnakers C; Laureys S

2013-09-01

52

Massa ventricular e critérios eletrocardiográficos de hipertrofia: avaliação de um novo escore/ Ventricular mass and electrocardiographic criteria of hypertrophy: evaluation of new score  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese FUNDAMENTO: A hipertrofia ventricular esquerda (HVE) é um importante e independente fator de risco cardiovascular. Inexistem, no Brasil, estudos desenhados para testar a eficácia do eletrocardiograma (ECG) no diagnóstico desse grave processo patológico. OBJETIVO: Avaliar um novo escore eletrocardiográfico para diagnóstico de HVE pelo ECG: soma da maior amplitude da onda S com a maior da onda R no plano horizontal, multiplicando-se o resultado pela duração do QRS [ (more) (S+R) X QRS)] e comparando-o com os critérios eletrocardiográficos clássicos. MÉTODOS: Foram analisados os ecocardiogramas e ECG de 1.204 pacientes hipertensos em tratamento ambulatorial. Avaliou-se o índice de massa do ventrículo esquerdo (IMVE) pelo ecocardiograma, firmando-se o diagnóstico de HVE quando > 96 g/m² para mulheres e > 116 g/m² para homens. No ECG analisaram-se quatro critérios clássicos de HVE, além do novo escore a ser testado. RESULTADOS: Todos os índices estudados tiveram correlação estatisticamente significativa com a massa calculada do ventrículo esquerdo (VE). Porém, o novo escore foi o que apresentou maior correlação (r = 0,564). Os outros critérios apresentaram as seguintes correlações: Romhilt-Estes (r = 0,464); Sokolow-Lyon (r = 0,419); Cornell voltagem (r = 0,377); Cornell duração (r = 0,444). Para avaliação da acurácia do índice testado, utilizou-se o ponto de corte de 2,80 mm.s. Com esse valor foram obtidas as seguintes cifras para sensibilidade e especificidade: 35,2% e 88,7%, respectivamente. CONCLUSÃO: Todos os critérios eletrocardiográficos para avaliação da massa do VE apresentaram baixa sensibilidade. O novo escore foi o que apresentou melhor correlação com o IMVE em relação aos outros avaliados. Abstract in english BACKGROUND: The left ventricular hypertrophy (LVH) is an important and independent cardiovascular risk factor. There is a scarcity of studies in Brazil designed to test the efficacy of the electrocardiogram (ECG) in the diagnosis of this important pathological process. OBJECTIVE: To evaluate a new electrocardiographic score for the diagnosis of LVH by ECG: the sum of the highest amplitude of the S wave and the highest amplitude of the R wave on the horizontal plane, multi (more) plied by the result of the QRS duration [(S+R) X QRS)] and comparing it with the classic electrocardiographic criteria. METHODS: The echocardiograms and ECG of 1,204 hypertensive patients receiving outpatient care were evaluated. The left ventricular mass index (LVMI) was assessed by the echocardiogram, with a diagnosis of LVH when the LVMI was > 96 g/m² for women and > 116 g/m² for men. Four classic criteria of LVH were analyzed at the ECG, in addition to the new score to be tested. RESULTS: In general, the studied ECG-LVH criteria showed significant statistical correlation to the echocardiographic LVMI. The (R+S) X QRS index, using 2.80 mm.s as the cutoff value, provided test accuracy regarding sensibility and specificity of 35.2% and 88.71%, respectively, representing the best correlation to LVMI (r=0.564) when compared to the other indexes: Romhilt-Estes (r=0.464); Sokolow-Lyon (r=0.419); Cornell voltage (r=0.377); Cornell product r=0.444). CONCLUSION: All the electrocardiographic criteria used for the assessment of the LV mass presented low sensitivity. The new score presented the best correlation with LVMI when compared to the other indexes.

Mazzaro, Cléber do Lago; Costa, Francisco de Assis; Bombig, Maria Teresa Nogueira; Luna Filho, Bráulio; Paola, Ângelo Amato Vincenzo de; Carvalho, Antonio Carlos de Camargo; Costa, William da; Fonseca, Francisco Antonio Helfenstein; Póvoa, Rui Manoel dos Santos

2008-04-01

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MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage  

DEFF Research Database (Denmark)

INTRODUCTION: The aim of this study was to investigate the magnetic resonance imaging (MRI) features of bone disease in the arthritis mutilans (AM) form of psoriatic arthritis (PsA). METHODS: Twenty-eight patients with erosive PsA were enrolled (median disease duration of 14 years). Using x-rays of both hands and feet, 11 patients were classified as AM and 17 as non-AM (erosive psoriatic arthritis without bone lysis)by two observers. MRI scans (1.5T) of the dominant hand (wrist and fingers scanned separately) were obtained using standard contrast-enhanced T1-weighted and fat-saturated T2-weighted sequences. Scans were scored separately by two readers for bone erosion, oedema and proliferation using a PsA MRI scoring system. X-rays were scored for erosions and joint space narrowing. RESULTS: On MRI, 1013 bones were scored by both readers. Reliability for scoring erosions and bone oedema was high (intraclass correlation coefficients = 0.80 and 0.77 respectively) but only fair for bone proliferation (intraclass correlation coefficient = 0.42). MRI erosion scores were higher in AM patients (53.0 versus 15.0, p = 0.004) as were bone oedema and proliferation scores (14.7 versus 10.0, p = 0.056 and 3.6 versus 0.7, p = 0.003 respectively). MRI bone oedema scores correlated with MRI erosion scores and X-ray erosion and joint space narrowing scores (r = 0.65, p = 0.0002 for all) but not the disease activity score 28-C reactive protein (DAS28CRP) or pain scores. CONCLUSIONS: In this patient group with PsA, MRI bone oedema, erosion and proliferation were all more severe in the AM-form. Bone oedema scores did not correlate with disease activity measures but were closely associated with X-ray joint damage scores. These results suggest that MRI bone oedema may be a pre-erosive feature and that bone damage may not be coupled with joint inflammation in PsA.

Tan, Yu M; Østergaard, Mikkel

2009-01-01

54

Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis.  

UK PubMed Central (United Kingdom)

BACKGROUND: Many genetic risk variants are now well established in multiple sclerosis (MS), but the impact on clinical phenotypes is unclear. OBJECTIVE: To investigate the impact of established MS genetic risk variants on MS phenotypes, in well-characterized MS cohorts. METHODS: Norwegian MS patients (n = 639) and healthy controls (n = 530) were successfully genotyped for 61 established MS-associated single nucleotide polymorphisms (SNPs). Data including and excluding Major Histocompatibility Complex (MHC) markers were summed to a MS Genetic Burden (MSGB) score. Study replication was performed in a cohort of white American MS patients (n = 1997) and controls (n = 708). RESULTS: The total human leukocyte antigen (HLA) and the non-HLA MSGB scores were significantly higher in MS patients than in controls, in both cohorts (P < 10(-22)). MS patients, with and without cerebrospinal fluid (CSF) oligoclonal bands (OCBs), had a higher MSGB score than the controls; the OCB-positive patients had a slightly higher MSGB than the OCB-negative patients. An early age at symptom onset (AAO) also correlated with a higher MSGB score, in both cohorts. CONCLUSION: The MSGB score was associated with specific clinical MS characteristics, such as OCBs and AAO. This study underlines the need for well-characterized, large cohorts of MS patients, and the usefulness of summarizing multiple genetic risk factors of modest effect size in genotype-phenotype analyses.

Harbo HF; Isobe N; Berg-Hansen P; Bos SD; Caillier SJ; Gustavsen MW; Mero IL; Celius EG; Hauser SL; Oksenberg JR; Gourraud PA

2013-10-01

55

Baseline level of functional C1-inhibitor correlates with disease severity scores in hereditary angioedema.  

UK PubMed Central (United Kingdom)

The diagnosis of hereditary angioedema (HAE) is based on complement tests. We studied for the first time the possible association between complement parameters measured at the time of diagnosis and disease severity in 115 patients with HAE. Serum levels of functional C1-inhibitor (C1-INH(f)), antigenic C1-inhibitor (C1-INH(a)), C4 and hemolytic activity of the classical pathway (CH50) were determined at the time of diagnosis. We found a significant correlation between severity scores and baseline C1-INH(f) levels, as determined by ELISA assay (p=0.0003). On the other hand, there was no correlation between severity scores and other complement parameters (C1-INH(a), C4, and CH50). We consider the correlation between severity scores and baseline C1-INH(f) levels an important pathophysiological observation. Our findings underlie the potential significance of monitoring functional C1-INH levels in relation to clinical disease course.

Kelemen Z; Moldovan D; Mihály E; Visy B; Széplaki G; Csuka D; Füst G; Farkas H; Varga L

2010-03-01

56

Baseline level of functional C1-inhibitor correlates with disease severity scores in hereditary angioedema.  

Science.gov (United States)

The diagnosis of hereditary angioedema (HAE) is based on complement tests. We studied for the first time the possible association between complement parameters measured at the time of diagnosis and disease severity in 115 patients with HAE. Serum levels of functional C1-inhibitor (C1-INH(f)), antigenic C1-inhibitor (C1-INH(a)), C4 and hemolytic activity of the classical pathway (CH50) were determined at the time of diagnosis. We found a significant correlation between severity scores and baseline C1-INH(f) levels, as determined by ELISA assay (p=0.0003). On the other hand, there was no correlation between severity scores and other complement parameters (C1-INH(a), C4, and CH50). We consider the correlation between severity scores and baseline C1-INH(f) levels an important pathophysiological observation. Our findings underlie the potential significance of monitoring functional C1-INH levels in relation to clinical disease course. PMID:19945350

Kelemen, Zsuzsanna; Moldovan, Dumitru; Mihály, Eniko; Visy, Beáta; Széplaki, Gábor; Csuka, Dorottya; Füst, George; Farkas, Henriette; Varga, Lilian

2009-11-27

57

Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. MATERIALS AND METHODS: The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained. RESULTS: Mean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P??0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P?>?0.05). CONCLUSION: ADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH. TEACHING POINTS : • In chronic viral hepatitis apparent coefficient values are decreased in the liver • There is no correlation between ADC values and histopathologic severity of CVH • DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis.

Onur MR; Poyraz AK; Bozdag PG; Onder S; Aygun C

2013-06-01

58

Correlation of high-molecular cytokeratin in tissue of prostatic cancer with gleason score and PSA  

Directory of Open Access Journals (Sweden)

Full Text Available The absence of basal cell layer of prostatic acini containing high-molecular cytokeratin, which is immunohistochemically detected by monoclonal antibody 34?E12, is an essential diagnostic characteristic of prostatic cancer. The absence of im munohistochemical reaction in 3 or more pseudo glandular structures of prostatic tissue indicates malignant process. The percentage of immunohistochemically completely negative glandular structures was determined by semiquantitative measurement in tissue specimens obtained by TRUS biopsy of the prostate, and it was correlated with serum PSA concentration and Gleason score. The increase of percentage of glandular prostatic formations completely negative to high-molecular cytokeratin detected by 34?E12 led to simultaneous rise of mean value of Gleason prostatic cancer score (p<0.001) as well as the average serum PSA concentration in subjects (p<0.05).

A?imovi? Miodrag; Govedarevi? V.; Mitrovi? D.; Radosavljevi? R.; Hadži-?oki? Jova; Tuli? Cane; Džami? Zoran; Jovanovi? M.; Živkovi? K.; Babi? M.; Markovi?-Lipkovski J.

2005-01-01

59

Using IQ Discrepancy Scores To Examine the Neural Correlates of Specific Cognitive Abilities.  

Science.gov (United States)

The underlying neural determinants of general intelligence have been studied intensively, and seem to derive from the anatomical and functional characteristics of a frontoparietal network. Little is known, however, about the underlying neural correlates of domain-specific cognitive abilities, the other factors hypothesized to explain individual performance on intelligence tests. Previous preliminary studies have suggested that spatially distinct neural structures do not support domain-specific cognitive abilities. To test whether differences between abilities that affect performance on verbal and performance tasks derive instead from the morphological features of a single anatomical network, we assessed in two independent samples of healthy human participants (N = 83 and N = 58; age range, 5-57 years) the correlation of cortical thickness with the magnitude of the verbal intelligence quotient (VIQ)-performance intelligence quotient (PIQ) discrepancy. We operationalized the VIQ-PIQ discrepancy by regressing VIQ onto PIQ (VIQ-regressed-on-PIQ score), and by regressing PIQ onto VIQ (PIQ-regressed-on-VIQ score). In both samples, a progressively thinner cortical mantle in anterior and posterior regions bilaterally was associated with progressively greater (more positive) VIQ-regressed-on-PIQ scores. A progressively thicker cortical mantle in anterior and posterior regions bilaterally was associated with progressively greater (more positive) PIQ-regressed-on-VIQ scores. Variation in cortical thickness in these regions accounted for a large portion of the overall variance in magnitude of the VIQ-PIQ discrepancy. The degree of hemispheric asymmetry in cortical thickness accounted for a much smaller but statistically significant portion of variance in VIQ-PIQ discrepancy. PMID:23986248

Margolis, Amy; Bansal, Ravi; Hao, Xuejun; Algermissen, Molly; Erickson, Cole; Klahr, Kristin W; Naglieri, Jack A; Peterson, Bradley S

2013-08-28

60

Using IQ Discrepancy Scores To Examine the Neural Correlates of Specific Cognitive Abilities.  

UK PubMed Central (United Kingdom)

The underlying neural determinants of general intelligence have been studied intensively, and seem to derive from the anatomical and functional characteristics of a frontoparietal network. Little is known, however, about the underlying neural correlates of domain-specific cognitive abilities, the other factors hypothesized to explain individual performance on intelligence tests. Previous preliminary studies have suggested that spatially distinct neural structures do not support domain-specific cognitive abilities. To test whether differences between abilities that affect performance on verbal and performance tasks derive instead from the morphological features of a single anatomical network, we assessed in two independent samples of healthy human participants (N = 83 and N = 58; age range, 5-57 years) the correlation of cortical thickness with the magnitude of the verbal intelligence quotient (VIQ)-performance intelligence quotient (PIQ) discrepancy. We operationalized the VIQ-PIQ discrepancy by regressing VIQ onto PIQ (VIQ-regressed-on-PIQ score), and by regressing PIQ onto VIQ (PIQ-regressed-on-VIQ score). In both samples, a progressively thinner cortical mantle in anterior and posterior regions bilaterally was associated with progressively greater (more positive) VIQ-regressed-on-PIQ scores. A progressively thicker cortical mantle in anterior and posterior regions bilaterally was associated with progressively greater (more positive) PIQ-regressed-on-VIQ scores. Variation in cortical thickness in these regions accounted for a large portion of the overall variance in magnitude of the VIQ-PIQ discrepancy. The degree of hemispheric asymmetry in cortical thickness accounted for a much smaller but statistically significant portion of variance in VIQ-PIQ discrepancy.

Margolis A; Bansal R; Hao X; Algermissen M; Erickson C; Klahr KW; Naglieri JA; Peterson BS

2013-08-01

 
 
 
 
61

Correlation of a quantitative videocapillaroscopic score with the development of digital skin ulcers in scleroderma patients  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and visceral organs. The microangiopathy is early detectable in the course of the disease by nailfold videocapillaroscopy (NVC), a non-invasive technique with a high diagnostic value. Objective: Aim of our study was to evaluate the feasibility of a quantitative score and its correlation with the digital skin ulcers, which frequently complicate SSc microangiopathy. Methods: We retrospectively analysed the NVC of 65 SSc patients, performed by 200x videocapillaroscopy connected to image analyse software (Videocap; DS MediGroup, Milan, Italy). The analysis of NVC images included: total number of capillaries in the distal row (N), maximum diameter (D) and number of giant capillaries (M), M/N ratio and percentage of M, presence/absence of micro-haemorrhages and tortuosity. Results: 21/65 SSc patients experienced digital ulcers within three months after the NVC examination. The N, D, M/N, and percentage of M significantly correlated with the appearance of ischemic ulcers. A multiple regression analysis showed a statistically significant correlation for N, M/N and D, while sensitivity and specificity of these parameters were unsatisfactory. A capillaroscopic score, according to the formula D·M/N2, showed a high specificity and sensibility (93.2% and 85.7% respectively; area under ROC curve: 0.918) to predict the appearance of digital ulcers. Conclusions: This capillaroscopic score may represent a feasible and simple tool in SSc patients’ assessment. The routinely use of this parameter might permit to recognize and to preventively treat SSc patients at high risk to develop digital ulcers.

M. Sebastiani; A. Manfredi; M. Colaci; D. Giuggioli; R. La Sala; N. Elkhaldi; A. Antonelli; C. Ferri

2011-01-01

62

Ecological Validity and Neuroanatomical Correlates of the NIH EXAMINER Executive Composite Score.  

UK PubMed Central (United Kingdom)

Executive functions refer to a constellation of higher-level cognitive abilities that enable goal-oriented behavior. The NIH EXAMINER battery was designed to assess executive functions comprehensively and efficiently. Performance can be summarized by a single score, the "Executive Composite," which combines measures of inhibition, set-shifting, fluency, and working memory. We evaluated the ecological validity of the Executive Composite in a sample of 225 mixed neurological patients and controls using the Frontal Systems Behavior Scale (FrSBe), an informant-based measure of real-world executive behavior. In addition, we investigated the neuroanatomical correlates of the Executive Composite using voxel-based morphometry in a sample of 37 participants diagnosed with dementia, mild cognitive impairment, or as neurologically healthy. The Executive Composite accounted for 28% of the variance in Frontal Systems Behavior Scale scores beyond age. Even after including two widely used executive function tests (Trails B and Stroop) as covariates, the Executive Composite remained a significant predictor of real-world behavior. Anatomically, poorer scores on the Executive Composite were associated with smaller right and left dorsolateral prefrontal volumes, brain regions critical for good executive control. Taken together, these results suggest that the Executive Composite measures important aspects of executive function not captured by standard measures and reflects the integrity of frontal systems. (JINS, 2013, 19, 1-9).

Possin KL; Lamarre AK; Wood KA; Mungas DM; Kramer JH

2013-06-01

63

A Study on the Correlation between Cord Blood Glucose Level and the Apgar Score  

Science.gov (United States)

Introduction: The study of the biochemical parameters of cord blood acts as a mirror, which usually reflects the neonatal status. The widely used system for the evaluation of a neonate is the Apgar score. There is no comprehensive published data which has established the association between the cord blood glucose level and the Apgar score. Similarly, there is also no well accepted reference range of the cord blood glucose level. Objectives: The main objectives of the present study was to ascertain any adverse effects of an abnormal cord blood glucose level on the neonatal status and to find out a standard reference level of glucose in cord blood. Methods: The cord blood glucose estimation was done by using the glucose oxidase peroxidase method and the statistical analysis was performed by using the SPSS, version 16 software. Results and Conclusions: In the present study, the cord blood glucose level was found to have no correlation with the Apgar scores which were calculated at both one minute and five minutes after birth. It was also found that for the foetus to be free from any obvious complication, the cord blood glucose level had to be around 87 mg/dl. The fluctuations in the maternal glucose levels are weakly associated with the glucose level in the cord blood.

Khan, Kalyan; Saha, Ashis Ranjan

2013-01-01

64

Correlation between clinical clerkship achievement and objective structured clinical examination (OSCE) scores of graduating dental students on conservative dentistry.  

UK PubMed Central (United Kingdom)

OBJECTIVES: This study aimed to investigate the effect of clinical clerkship-associated achievements, such as performance of procedures at the student clinic, observation, and attitude towards a clerkship, on the objective structured clinical examination (OSCE) scores of dental students graduating in restorative dentistry. MATERIALS AND METHODS: The OSCEs consisted of two stations designed to assess students' clinical skills regarding cavity preparation for a class II gold inlay and a class IV composite restoration. The clerkship achievements, consisting of the number of student clinical procedures performed, observation-related OSCE, and scores of their attitudes towards a conservative dentistry clerkship, were assessed. Correlation and multiple regression analyses were conducted. RESULTS: The correlation coefficient between the OSCE scores for cavity preparation for a class II gold restoration and clerkship attitude scores was 0.241 (p < 0.05). Regarding a class IV composite restoration, OSCE scores showed statistically significant correlations with the observation (r = 0.344, p < 0.01) and attitude (r = 0.303, p < 0.01) scores. In a multiple regression analysis, attitudes towards a clerkship (p = 0.033) was associated with the cavity preparation for a class II gold inlay OSCE scores, while the number of procedure observations (p = 0.002) was associated with the class IV composite restoration OSCE scores. CONCLUSIONS: The number of clinical procedures performed by students, which is an important requirement for graduation, showed no correlation with either of the OSCEs scores.

Bang JB; Choi KK

2013-05-01

65

CORRELATION BETWEEN SYMPTOM SCORE, WHEEZE, REVERSIBILITY OF PULMONARY FUNCTION TESTS AND TREATMENT RESPONSE IN ASTHMA  

Directory of Open Access Journals (Sweden)

Full Text Available Asthma management is a major concern because some asthmatic patients either do not respond or else hardly respond to treatment. Therefore in the present study, an attempt has been made to determine the predictors of treatment response in asthmatic patients.Thirty six asthmatic adults including 13 male and 23 female were studied dur¬ing a 3 month treatment period. Asthma symptom score (SS) and wheezing were recorded before and after treatment. Pulmonary function tests (PFTs) including forced vital capacity (FVC), forced expiratory volume in one second (FEVj), peak expiratory flow (PEF), maximal expiratory measured at the beginning and the end of the study. The increase in PFT values 10 min after 200 ug inhaled salbutamol (in percentage) was considered as reversibility in airway constriction.There were significant improvements in SS (/JKO.001) and PFT variables (/;><0.05 topO.001) except of MEF2S due to 3 months treatment. However, the reversibility of airway constriction improved after treatment but these improve¬ments were not statistically significant except that of PEF (p<0.05). There were significant correlations between both baseline symptom score and wheeze with an improvement seen in these two parameters (p<0.05 to p(0.001). There were also significant correlations between reversibility in FEV, with improvement in FEV and MEF25 aftet treatment and between reversibility in PEF and improve¬ment in FEV, at end of the study Q]<0.Q5 to/KO.001).The results of these study showed that a well conducted therapeutic program could lead to improvement in symptoms, wheeze, and PFT values. In addition symptom score, wheeze, and reversibility in FEV1 and PEF could be good indi¬cators of response to treatment in asthma.

M.H. Boskabady; M. Fasihfar; G.A. Maemoori

2003-01-01

66

Correlation between serum serotonin and endoscopy inflammation scores in patients with ileal pouches.  

UK PubMed Central (United Kingdom)

BACKGROUND: Inflammatory and functional complications are common in patients with inflammatory bowel disease (IBD) after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA). The pathogenesis of these complications remains poorly understood, and there is discrepancy between the clinical symptoms and objective endoscopic inflammation scores in these patients. While serum serotonin level has been reported to be associated with symptoms of irritable bowel syndrome, its association with ileal pouch disorders has not been studied. AIM: To investigate the association between serum serotonin level and symptoms and endoscopic inflammation in patients with IPAA. METHODS: A total of 185 consecutive eligible IPAA patients who presented to a specialized Pouchitis Clinic from Jan 2009 to May 2009 were prospectively recruited. Patients were divided into 4 groups: normal pouch, irritable pouch syndrome (IPS), inflammatory pouch disorders (Crohn's disease, acute and chronic pouchitis, and cuffitis), and surgical complications. Serum serotonin level was measured and analyzed for correlation with clinical and endoscopic inflammation scores. RESULTS: Demographic and clinical variables were evaluated, including age, gender, smoking history, duration of UC, duration of the pouch, and disease category of the pouch. The median fasting serum serotonin level was comparable among the 4 groups: 94.0 ng/ml (interquartile range [IQR], 70.0, 128.1), 89.2 ng/ml (IQR 54.2, 155.9), 90.3 ng/ml (IQR 49.7, 164.1), 77.9 ng/ml (IQR 54.7, 129.0), for normal pouch, irritable pouch, inflammatory pouch disorders, and surgical complication groups, respectively (p=0.91). A significant association between serum serotonin level and the Pouchitis Disease Activity Index (PDAI) endoscopy subscore of the pouch (odds ratio [OR]=1.9, 95% confidence interval [CI]: 1.2, 2.9, p<0.05) and total PDAI endoscopy score (OR=1.8; 95% CI: 1.2, 2.8, p<0.05) in the inflammatory complication group were noted. CONCLUSIONS: Serum serotonin level appears to correlate with the PDAI endoscopy subscores and total PDAI score in patients with inflammatory complications suggesting that the hormone may be involved in mechanisms of mucosal inflammation. These findings may promote future treatment strategies for patients with pouch inflammation.

Wang Y; Gong H; Lopez R; Lian L; Kiran RP; Soffer EE; Shen B

2013-05-01

67

Big Macs and Eigenfactor Scores: Don't Let Correlation Coefficients Fool You  

CERN Multimedia

The Eigenfactor Metrics provide an alternative way of evaluating scholarly journals based on an iterative ranking procedure analogous to Google's PageRank algorithm. These metrics have recently been adopted by Thomson-Reuters and are listed alongside the Impact Factor in the Journal Citation Reports. But do these metrics differ sufficiently so as to be a useful addition to the bibliometric toolbox? Davis (2008) has argued otherwise, based on his finding of a 0.95 correlation coefficient between Eigenfactor score and total citations for a sample of journals in the field of medicine. This conclusion is mistaken; here we illustrate the basic statistical fallacy to which Davis succumbed. We provide a complete analysis of the 2006 Journal Citation Reports and demonstrate that there are important differences between the information provided by the Eigenfactor Metrics and that provided by Impact Factor and Total Citations.

West, Jevin; Bergstrom, Carl

2009-01-01

68

Multiple cores of Gleason score 6 correlate with favourable findings at radical prostatectomy.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To establish whether the good prognosis of Gleason score 6 (GS6) is maintained in the setting of multiple involved cores. PATIENTS AND METHODS: In total, 6156 men (from 1 April 2000 to 30 April 2007) with GS6 on biopsy underwent radical prostatectomy (RP) at our institution. The number of positive cores was correlated with the outcome at RP. RESULTS: More positive cores correlated with less organ-confined disease (P < 0.001), positive margins (P < 0.012), increasing RP grade (P < 0.001) and increased seminal vesicles/lymph node involvement (P = 0.012). For men with data available, the actuarial risk of being biochemically free of disease at 5 years was 93.2% when ?6 cores were positive (812 men followed to 5 years) vs 89.1% if >6 cores were positive (41 men followed to 2 years) (P = 0.6). Although the predicted 'cure rate' of >75% probability of a tumour showing no evidence of biochemical recurrence at 10 years after RP was statistically different between cases with ?6 vs >6 positive cores (P < 0.0001), the outcome in both groups was still favourable (90.5% vs 84%). Partin-like tables were generated factoring in the number of positive cores to predict organ-confined disease as a guide for urologists to perform nerve-sparing surgery. For example, with T1c disease, there was a ?75% probability of organ-confined disease with one to three positive cores regardless of prostate-specific antigen (PSA) level, and the same probability was present with four to six positive cores and a PSA level of 0-4 ng/mL. CONCLUSION: A low Gleason score on biopsy is a powerful prognostic finding, such that this favourable outcome is maintained even in the setting of multiple positive cores with GS6.

Ellis CL; Walsh PC; Partin AW; Epstein JI

2013-06-01

69

Correlación entre score de calcio coronario, esteatosis hepática y síndrome metabólico/ Correlation between coronary calcium score, hepatic steatosis and metabolic syndrome  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Objetivos. Demostrar la correlación que existe entre presencia o no de enfermedad coronaria establecida (medida a través del índice de Agatston) y esteatosis hepática en los segmentos visualizados del hígado al momento de realizar el score de calcio. Material y Métodos. Estudio retrospectivo que incluyó 229 pacientes con factores de riesgo para enfermedad coronaria a los que se les realizó tomografía computada multicorte de arterias coronarias o score de calcio. (more) Se evaluó la presencia de enfermedad ateromatosa en arterias coronarias y aorta torácica y atenuación hepática en los segmentos visualizados del hígado. El análisis estadístico incluyó modelos de regresión lineal, estudio por asociación de múltiples variables y modelo CART. Resultados. 229 pacientes, 78% de sexo masculino y 22% femenino, con edad promedio 56 años. Se demostró asociación estadísticamente significativa entre mayor nivel de score de calcio y menor atenuación hepática, en pacientes de mayor edad y sexo masculino. Se logró definir dos tipos de pacientes con score de calcio elevado, un grupo con hipertensión arterial - esteatosis hepática y otro grupo con hipertensión arterial y diabetes tipo 2; los pacientes solamente obesos no tenían mayores niveles de score de calcio. Conclusiones. Existe asociación entre ateromatosis calcificada y esteatosis hepática. Los pacientes con esteatosis hepática como parte de un síndrome metabólico, tienen mayor riesgo de ateroesclerosis. Puede ser útil incorporar la evaluación de esteatosis hepática en la estratificación de riesgo cardiovascular. Abstract in english Objectives. To demonstrate the correlation between the presence or absence of established coronary disease (as measured by the Agatston index) and hepatic steatosis visualized in liver segments when calculating calcium score. Material and Methods. Retrospective study that included229 patients with risk factors for coronary disease who underwent multislice computed tomography of coronary arteries or calcium score. We evaluated the presence of atherosclerotic disease in cor (more) onary arteries and thoracic aorta and liver attenuation in visualized liver segments. Statistical analysis included linear regression models, association studies of multiple variables and CARTmodel. Results. 229 patients, 78% male, average age 56 years. It values statistically significant association was found between higher levels of calcium score and lower hepatic attenuation in older patients and males. We were to define two types of patients with high calcium score, a group with hypertension - hepatic steatosis and another groups with hypertension and type 2 diabetes; patients that were only obese did not have higher levels of calcium score. Conclusions. A relationship exists between calcified atheromatosis disease and hepatics steatosis. Patients with hepatics steatosis as part of a metabolic syndrome are at increased risk of atherosclerosis. It may be useful to incorporate the assessment of hepatics steatosis in cardiovascular risk stratification.

Hermosilla M, Karina; Pivcevic C, Daniela; Alegria B, Julia; Silva F, Claudio

2013-01-01

70

Correlation between an email based board review program and American Board of Pediatrics General Pediatrics Certifying Examination scores.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To investigate the impact of a weekly email based board review course on individual resident performance on the American Board of Pediatrics (ABP) General Pediatrics Certifying Examination for pediatric residents and, specifically, residents with low ABP In-training Examination (ITE) scores. METHODS: Weekly board-type questions were emailed to all pediatric residents from 2004-2007. Responses to board-type questions were tracked, recorded, and correlated with ITE scores and ABP General Pediatrics Certifying Examination Scores. RESULTS: With regard to total number of questions answered, only total number of questions answered correctly had a significant positive correlation with standard board scores (n = 71, r = 0.24, p = 0.047). For "at risk" residents with ITE scores correlations with standard board scores. CONCLUSIONS: Participating regularly in the email-based board review course, answering board style questions, and answering correctly to board style questions were associated with higher standard board scores. This benefit existed for all but was especially prominent among those with poor in-training examination scores.

Langenau EE; Fogel J; Schaeffer HA

2009-01-01

71

[Correlation between serum growth differentiation factor-15 and TIMI risk scores in patients with unstable angina pectoris].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To explore the correlation between serum levels of growth differentiation factor-15 (GDF-15) and Thrombolysis in Myocardial Infarction (TIMI) risk scores in patients with unstable angina pectoris (UA). METHODS: The serum levels of GDF-15 in 97 patients with UA and 30 healthy volunteers were measured using enzyme-linked immunosorbent assay (ELISA) and compared between 3 patient groups with different TIMI scores to analyze relationship between serum GDF-15 levels and TIMI risk scores. RESULTS: The serum levels of GDF-15 in UA patients were significantly higher than those in the healthy volunteers (P<0.01). GDF-15 levels also differed significantly between patients with different TIMI scores (P<0.01), and showed a significant positive correlation to TIMI risk scores. CONCLUSION: Serum levels of GDF-15 can be used as an index for evaluating the severity of UA.

Deng MY; Wu GP; Feng XX; Luo JB

2011-06-01

72

Scoring Selection Criteria Including Total Tumour Volume and Pretransplant Percentage of Lymphocytes to Predict Recurrence of Hepatocellular Carcinoma after Liver Transplantation  

Science.gov (United States)

Aim The selection criteria for patients with hepatocellular carcinoma (HCC) to undergo liver transplantation should accurately predict posttransplant recurrence while not denying potential beneficiaries. In the present study, we attempted to identify risk factors associated with posttransplant recurrence and to expand the selection criteria. Patients and Methods Adult patients with HCC who underwent liver transplantation between November 2004 and September 2012 at our centre were recruited into the current study (N?=?241). Clinical and pathological data were retrospectively reviewed. Patients who died during the perioperative period or died of non-recurrence causes were excluded from this study (N?=?25). All potential risk factors were analysed using uni- and multi-variate analyses. Results Sixty-one recipients of 216 qualified patients suffered from recurrence. Similar recurrence-free and long-term survival rates were observed between living donor liver transplant recipients (N?=?60) and deceased donor liver transplant recipients (N?=?156). Total tumour volume (TTV) and preoperative percentage of lymphocytes (L%) were two independent risk factors in the multivariate analysis. We propose a prognostic score model based on these two risk factors. Patients within our criteria achieved a similar recurrence-free survival to patients within the Milan criteria. Seventy-one patients who were beyond the Milan criteria but within our criteria also had comparable survival to patients within the Milan criteria. Conclusions TTV and L% are two risk factors that contribute to posttransplant recurrence. Selection criteria based on these two factors, which are proposed by our study, expanded the Milan criteria without increasing the risk of posttransplant recurrence.

Li, Chuan; Wen, Tian-Fu; Yan, Lu-Nan; Li, Bo; Yang, Jia-Ying; Xu, Ming-Qing; Wang, Wen-Tao; Wei, Yong-Gang

2013-01-01

73

Scoring selection criteria including total tumour volume and pretransplant percentage of lymphocytes to predict recurrence of hepatocellular carcinoma after liver transplantation.  

UK PubMed Central (United Kingdom)

AIM: The selection criteria for patients with hepatocellular carcinoma (HCC) to undergo liver transplantation should accurately predict posttransplant recurrence while not denying potential beneficiaries. In the present study, we attempted to identify risk factors associated with posttransplant recurrence and to expand the selection criteria. PATIENTS AND METHODS: Adult patients with HCC who underwent liver transplantation between November 2004 and September 2012 at our centre were recruited into the current study (N?=?241). Clinical and pathological data were retrospectively reviewed. Patients who died during the perioperative period or died of non-recurrence causes were excluded from this study (N?=?25). All potential risk factors were analysed using uni- and multi-variate analyses. RESULTS: Sixty-one recipients of 216 qualified patients suffered from recurrence. Similar recurrence-free and long-term survival rates were observed between living donor liver transplant recipients (N?=?60) and deceased donor liver transplant recipients (N?=?156). Total tumour volume (TTV) and preoperative percentage of lymphocytes (L%) were two independent risk factors in the multivariate analysis. We propose a prognostic score model based on these two risk factors. Patients within our criteria achieved a similar recurrence-free survival to patients within the Milan criteria. Seventy-one patients who were beyond the Milan criteria but within our criteria also had comparable survival to patients within the Milan criteria. CONCLUSIONS: TTV and L% are two risk factors that contribute to posttransplant recurrence. Selection criteria based on these two factors, which are proposed by our study, expanded the Milan criteria without increasing the risk of posttransplant recurrence.

Li C; Wen TF; Yan LN; Li B; Yang JY; Xu MQ; Wang WT; Wei YG

2013-01-01

74

Heritability estimates associated with alternative definitions of mastitis and correlations with somatic cell score and yield.  

Science.gov (United States)

The objectives of this study were to compare alternative mastitis definitions and to estimate genetic correlations of producer-recorded mastitis with somatic cell score (SCS) and yield. Cow health events and lactation records from June 2002 through October 2007 were provided by Dairy Records Management Systems (Raleigh, NC). First- through fifth-lactation records from cows calving between 20 and 120 mo of age and that calved in a herd-year with at least 1% of cows with a clinical mastitis event were retained. The edited data contained 118,516 lactation records and 1,072,741 test-day records of 64,893 cows. Mastitis occurrence (1 = at least one mastitis event during lactation or test-day interval, 0 = no mastitis events), number of mastitis events during lactation, SCS, and yield were analyzed with animal models (single trait) or sire-maternal grandsire models (multiple trait) in ASREML. Comparisons were made among models assuming a normal distribution, a binary distribution, or Poisson distribution (for total episodes). The overall incidence of clinical mastitis was 15.4%; and heritability estimates ranged from 0.73% (test-day interval mastitis with a linear model) to 11.07% (number of mastitis episodes with a Poisson model). Increased mastitis incidence was genetically correlated with higher SCS (range 0.66 to 0.88) and was generally correlated with higher yield (range -0.03 to 0.40), particularly during first lactation (0.04 to 0.40). Significant genetic variation exists for clinical mastitis; and health events recorded by producers could be used to generate genetic evaluations for cow health. Sires ranked similarly for daughter mastitis susceptibility regardless of how mastitis was defined; however, test-day interval mastitis and a total count of mastitis episodes per lactation allow a higher proportion of mastitis treatments to be included in the genetic analysis. PMID:19528618

Vallimont, J E; Dechow, C D; Sattler, C G; Clay, J S

2009-07-01

75

Heritability estimates associated with alternative definitions of mastitis and correlations with somatic cell score and yield.  

UK PubMed Central (United Kingdom)

The objectives of this study were to compare alternative mastitis definitions and to estimate genetic correlations of producer-recorded mastitis with somatic cell score (SCS) and yield. Cow health events and lactation records from June 2002 through October 2007 were provided by Dairy Records Management Systems (Raleigh, NC). First- through fifth-lactation records from cows calving between 20 and 120 mo of age and that calved in a herd-year with at least 1% of cows with a clinical mastitis event were retained. The edited data contained 118,516 lactation records and 1,072,741 test-day records of 64,893 cows. Mastitis occurrence (1 = at least one mastitis event during lactation or test-day interval, 0 = no mastitis events), number of mastitis events during lactation, SCS, and yield were analyzed with animal models (single trait) or sire-maternal grandsire models (multiple trait) in ASREML. Comparisons were made among models assuming a normal distribution, a binary distribution, or Poisson distribution (for total episodes). The overall incidence of clinical mastitis was 15.4%; and heritability estimates ranged from 0.73% (test-day interval mastitis with a linear model) to 11.07% (number of mastitis episodes with a Poisson model). Increased mastitis incidence was genetically correlated with higher SCS (range 0.66 to 0.88) and was generally correlated with higher yield (range -0.03 to 0.40), particularly during first lactation (0.04 to 0.40). Significant genetic variation exists for clinical mastitis; and health events recorded by producers could be used to generate genetic evaluations for cow health. Sires ranked similarly for daughter mastitis susceptibility regardless of how mastitis was defined; however, test-day interval mastitis and a total count of mastitis episodes per lactation allow a higher proportion of mastitis treatments to be included in the genetic analysis.

Vallimont JE; Dechow CD; Sattler CG; Clay JS

2009-07-01

76

Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study  

DEFF Research Database (Denmark)

BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) are associated with decline in cognition, gait, mood, and urinary continence. Associations may depend on the method used for measuring WMH. We investigated the ability of different WMH scoring methods to detect differences in WMH load between groups with and without symptoms. METHODS: We used data of 618 independently living elderly with WMH collected in the Leukoaraiosis And DISability (LADIS) study. Subjects with and without symptoms of depression, gait disturbances, urinary incontinence, and memory decline were compared with respect to WMH load measured qualitatively using 3 widely used visual rating scales (Fazekas, Scheltens, and Age-Related White Matter Changes scales) and quantitatively with a semiautomated volumetric technique and an automatic lesion count. Statistical significance between groups was assessed with the chi2 and Mann-Whitney tests. In addition, the punctate and confluent lesion type with comparable WMH volume were compared with respect to the clinical data using Student t test and chi2 test. Direct comparison of visual ratings with volumetry was done using curve fitting. RESULTS: Visual and volumetric assessment detected differences in WMH between groups with respect to gait disturbances and age. WMH volume measurement was more sensitive than visual scores with respect to memory symptoms. Number of lesions nor lesion type correlated with any of the clinical data. For all rating scales, a clear but nonlinear relationship was established with WMH volume. CONCLUSIONS: Visual rating scales display ceiling effects and poor discrimination of absolute lesion volumes. Consequently, they may be less sensitive in differentiating clinical groups

van Straaten, EC; Fazekas, F

2006-01-01

77

Modified Chrispin-Norman chest radiography score for cystic fibrosis: observer agreement and correlation with lung function  

International Nuclear Information System (INIS)

To test observer agreement and two strategies for possible improvement (consensus meeting and reference images) for the modified Chrispin-Norman score for children with cystic fibrosis (CF). Before and after a consensus meeting and after developing reference images three observers scored sets of 25 chest radiographs from children with CF. Observer agreement was tested for line, ring, mottled and large soft shadows, for overinflation and for the composite modified Chrispin-Norman score. Correlation with lung function was assessed. Before the consensus meeting agreement between observers 1 and 2 was moderate-good, but with observer 3 agreement was poor-fair. Scores correlated significantly with spirometry for observers 1 and 2 (-0.72

2011-01-01

78

Correlation between CHADS2 score and anticoagulant use in atrial fibrillation: Results of a mini-survey.  

UK PubMed Central (United Kingdom)

Quality assurance in atrial fibrillation is related to the appropriate use of anticoagulation. The CHADS2 score is widely used to determine which patients should or should not be anticoagulated. The authors hypothesized that as thromboembolic risk and, therefore, the CHADS2 score increases, so should the rate of anticoagulant prescription. The authors found a positive correlation between CHADS2 score and anticoagulant prescription (r=0.8) in a mini-survey. Although anticoagulant use at CHADS2 score = 0 was presumed to be very low, it was found to be higher than expected. This was readily explained by a group of low-risk patients being anticoagulated before cardioversion. Cardioverted patients were then examined as a group and it was found that the rate of rhythm control decreased with CHADS2 score (r= -0.89), a finding that has not been reported in the literature and may warrant further investigation.

Cartman G; Blostein M; Eisenberg MJ

2013-01-01

79

Correlations of Plasma Citrulline Levels With The Clinical Score, Endoscopic Score, Blood Markers According to Small Bowel Involvement in Pediatric Crohn's Disease.  

UK PubMed Central (United Kingdom)

OBJECTIVE:: Several studies have indicated that plasma citrulline levels reflect the extent of mucosal injury of the small intestine. This study was performed to determine whether plasma citrulline levels correlate with the disease activity in pediatric Crohn's disease patients. METHODS:: A total of 63 Crohn's disease (CD) and 23 ulcerative colitis (UC) patients were included in this study. Disease severity was assessed by pediatric CD activity index (PCDAI), pediatric UC activity index (PUCAI), simplified endoscopic activity score for Crohn's disease (SES-CD), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). The correlations between these variables and plasma citrulline levels were evaluated. We performed subgroup analysis whether correlations beween plasma citrulline levels and disease activity depend on small bowel involvement in CD patients. RESULTS:: The plasma citrulline levels correlated negatively with CRP (r?=?-0.332, P?=?0.008), ESR (r?=?-0.290, P?=?0.022), and PCDAI (r?=?-0.424, P?=?0.001) in CD patients. The plasma citrulline levels were significantly lower in patients with jejunal involvement than in those without (P?=?0.027). In subgroup analysis, CD patients with jejunal involvement showed significantly negative correlations of plasma citrulline levels with CRP (r?=?-0.628, P?=?0.016) and PCDAI (r?=?-0.632, P?=?0.015); however, CD patients without jejunal involvement revealed no correlations of plasma citrulline levels with CRP and PCDAI. There were no significant correlations between plasma citrulline levels and SES-CD. There were no significant correlations of plasma citrulline levels with CRP, ESR, and PUCAI in UC patients. CONCLUSIONS:: Plasma citrulline levels correlated with disease severity as measured by PCDAI, CRP, and ESR in pediatric CD patients with jejunal involvement.

Lee EH; Ko JS; Seo JK

2013-06-01

80

Fractal dimension of bone texture in radiographs correlates to ultrasound broadband attenuation T-score.  

UK PubMed Central (United Kingdom)

OBJECTIVES: We aimed to measure the fractal dimension on x-ray images and ultrasonographic parameters of the os calcis of bone from 4 districts in osteoporotic patients and in control subjects, in order to test the hypothesis that ultrasonographic parameters correlate to the fractal dimension obtained on x-ray images. METHODS: Fractal analysis on radiological images from 4 bone districts (proximal femur, calcaneus, metacarpus and 3rd phalanx) was performed in a study comparing ultrasonographic evaluation of the os calcis in severe osteoporotic patients and in control cases. We studied 86 x-ray-views from patients with severe reduction of ultrasound Stiffness Index and in healthy women. Ultrasound measurements of left os calcis were performed using the Lunar Achilles-Plus instrument. Fractal analysis was performed using the box-counting method. RESULTS: In healthy subjects, fractal dimension, D, measure of structural complexity, resulted close to the topological dimension (no fractal structure), TD, in femur (1.99±0.03)and phalanx (1.96±0.03), D differed significantly from TD in calcaneus (D=1.90±0.02; p<0.001) and metacarpus (D=1.89±0.03, p<0.001). In osteoporotic subjects, in calcaneus and metacarpus, D was higher (1.94±0.03, 1.93±0.03, respectively) than in healthy subjects (1.90±0.02, 1.89±0.02, respectively, p<0.01). In all the subjects, fractal dimension and ultrasound broadband attenuation T-score correlated significantly in calcaneus and metacarpus (p<0.03 and p<0.02, respectively). CONCLUSIONS: Parameters based on a combination of ultrasonic examination and fractal analysis on radiographic images may add useful structural information regarding the patients' skeleton using non invasive procedures.

Bianciardi G; Bisogno S; Bertoldi I; Laurini L; Coviello G; Frediani B

2013-05-01

 
 
 
 
81

Increased expression of EphA1 protein in prostate cancers correlates with high Gleason score.  

Science.gov (United States)

The erythropoietin-producing hepatocellular (Eph) family of receptor tyrosine kinases regulates a multitude of physiological and pathological processes. EphA1 is the first member of Eph superfamily and is involved in carcinogenesis. The aim of this study was to investigate the expression of EphA1 in prostate cancers cell lines and the tissues, then explore the correlation with the clinicopathologic parameters. The EphA1 transcript expression in prostate cancer cell lines was detected by Quantitative real-time PCR. The expression of EphA1 protein in 138 prostate cancer tissue samples and 21 benign prostate hyperplasia samples were checked by using immunohistochemical staining. EphA1 mRNA was high expressed in LNCap, moderately expressed in 22RV1 and Du145, and lost in PC3. Loss of expression of EphA1 transcript was related to hypermethylation of CpG island around the translation start site. EphA1 protein was differentially expressed in prostate cancers and hyperplasia. Increased expression of EphA1 protein was more frequently detected in prostate cancers than in hyperplasia (P = 0.02), and more often detected in prostate cancer with high Gleason score (P < 0.001). Our data indicate that EphA1 receptor may have roles in carcinogenesis and progression of prostate cancer, and can be a potentially useful target for prognostic and therapeutic application. PMID:24040450

Peng, Libo; Wang, Haiyan; Dong, Yingchun; Ma, Jie; Wen, Juanjuan; Wu, Jinrong; Wang, Xueqing; Zhou, Xiaojun; Wang, Jiandong

2013-08-15

82

Correlation between the elastic-shear-instability-mechanism and empirical criteria for irradiation-induced amorphization  

Energy Technology Data Exchange (ETDEWEB)

In an attempt to correlate the shear instability mechanism with empirical criteria for irradiation-induced amorphization, shear moduli of an A{sub 3}B-type fcc crystal were calculated as a function of the chemical long range order parameter (S) using a Morse potential. The shear moduli were found to decrease with decreasing S. When the depth and the curvature of the A-B potential were changed while keeping the A-A and B-B potentials constant, the magnitude of the decrease in shear moduli is greater for deeper and narrower A-B potentials. The present results indicate that a shear instability should occur more readily in compounds with larger ordering energy and larger elastic moduli. These results agree with the reported empirical criteria for irradiation-induced amorphization, therefore providing further support for the shear instability mechanism for solid-state amorphization. 9 refs., 3 figs.

Koike, J. (Los Alamos National Lab., NM (USA)); Okamoto, P.R.; Rehn, L.E. (Argonne National Lab., IL (USA)); Meshii, M. (Northwestern Univ., Evanston, IL (USA). Dept. of Materials Science and Engineering)

1990-09-01

83

HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei.  

UK PubMed Central (United Kingdom)

Micronucleus (MN) expression in peripheral blood lymphocytes is well established as a standard method for monitoring chromosome damage in human populations. The first results of an analysis of pooled data from laboratories using the cytokinesis-block micronucleus (CBMN) assay and participating in the HUMN (HUman MicroNucleus project) international collaborative study are presented. The effects of laboratory protocol, scoring criteria, and host factors on baseline micronucleated binucleate cell (MNC) frequency are evaluated, and a reference range of "normal" values against which future studies may be compared is provided. Primary data from historical records were submitted by 25 laboratories distributed in 16 countries. This resulted in a database of nearly 7000 subjects. Potentially significant differences were present in the methods used by participating laboratories, such as in the type of culture medium, the concentration of cytochalasin-B, the percentage of fetal calf serum, and in the culture method. Differences in criteria for scoring micronuclei were also evident. The overall median MNC frequency in nonexposed (i.e., normal) subjects was 6.5 per thousand and the interquartile range was between 3 and 12 per thousand. An increase in MNC frequency with age was evident in all but two laboratories. The effect of gender, although not so evident in all databases, was also present, with females having a 19% higher level of MNC frequency (95% confidence interval: 14-24%). Statistical analyses were performed using random-effects models for correlated data. Our best model, which included exposure to genotoxic factors, host factors, methods, and scoring criteria, explained 75% of the total variance, with the largest contribution attributable to laboratory methods.

Bonassi S; Fenech M; Lando C; Lin YP; Ceppi M; Chang WP; Holland N; Kirsch-Volders M; Zeiger E; Ban S; Barale R; Bigatti MP; Bolognesi C; Jia C; Di Giorgio M; Ferguson LR; Fucic A; Lima OG; Hrelia P; Krishnaja AP; Lee TK; Migliore L; Mikhalevich L; Mirkova E; Mosesso P; Müller WU; Odagiri Y; Scarffi MR; Szabova E; Vorobtsova I; Vral A; Zijno A

2001-01-01

84

Reaction Time Correlations with Intelligence Test Scores Obtained under either Timed or Untimed Conditions.  

Science.gov (United States)

To assess the effects of timed/untimed testing conditions on intelligence scores, high school students were assigned to an intelligence test under either conditions and subsequently to a battery of eight reaction time tests. Results showed that subjects scores were related to the speed with which they processed information. (JAZ)

Vernon, Philip A.; Kantor, Lida

1986-01-01

85

Genetic susceptibility to multiple primary neoplasms in the upper aero-digestive tract: genotype score and phenotype correlation.  

Science.gov (United States)

Early detection and treatment of head and neck cancer has led to increased patient survival. However such patients are at a high risk for multiple primary neoplasm(s) (MPN). In order to study the genetic susceptibility to MPN, 22 candidate SNPs were genotyped based on which a distinctive Genotype Score was created using Additive, Dominant and Recessive models. Using lymphoblastoid cell lines (LCLs) generated from these individuals, the Genotype Score was correlated with carcinogen sensitivity in vitro. LCLs from MPN patients exhibited significantly higher Genotype Score and showed resistance to genotoxic agents compared to matched controls. This report demonstrates quantitative assessment of cumulative effect of gene polymorphisms and its correlation with carcinogen sensitivity for predicting susceptibility to MPN. PMID:23348701

Hussain, Tabish; Kotnis, Ashwin; Sarin, Rajiv; Mulherkar, Rita

2013-01-21

86

Genetic susceptibility to multiple primary neoplasms in the upper aero-digestive tract: genotype score and phenotype correlation.  

UK PubMed Central (United Kingdom)

Early detection and treatment of head and neck cancer has led to increased patient survival. However such patients are at a high risk for multiple primary neoplasm(s) (MPN). In order to study the genetic susceptibility to MPN, 22 candidate SNPs were genotyped based on which a distinctive Genotype Score was created using Additive, Dominant and Recessive models. Using lymphoblastoid cell lines (LCLs) generated from these individuals, the Genotype Score was correlated with carcinogen sensitivity in vitro. LCLs from MPN patients exhibited significantly higher Genotype Score and showed resistance to genotoxic agents compared to matched controls. This report demonstrates quantitative assessment of cumulative effect of gene polymorphisms and its correlation with carcinogen sensitivity for predicting susceptibility to MPN.

Hussain T; Kotnis A; Sarin R; Mulherkar R

2013-05-01

87

Quantitative evaluation of biopty gun testis needle biopsy. Correlation between biopsy score of varicocele-bearing testis and sperm count.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To investigate the applicability of quantitative evaluation of needle biopsy of the testis and any correlation between biopsy score and sperm parameters in infertile or subfertile men with varicocele. STUDY DESIGN: A total of 45 infertile men with clinical left varicocele were included in the study. All patients underwent left varicocelectomy and bilateral biopty gun needle biopsy of both testes. Spermiograms were obtained before and three months after the operation. The biopsy specimens were evaluated for Johnsen and Agger score, Leydig cell score, germ cell/Sertoli cell ratio, mean tubular diameter, peritubular fibrosis, and tubular and basement membrane hyalinization. RESULTS: Mean sperm count, motility and normally configured motile sperm counts increased 20%, 25% and 60% by month 3, respectively (P < .05). We did not observe any significant change in normally configured sperm counts. A mean of 14 tubuli per testis were obtained with single-pass needle biopsy. Johnsen and Agger scores, Leydig cell scores, mean tubular diameter and germ cell/Sertoli cell ratios of both testes were comparable. However, there was significantly less peritubular fibrosis, tubular hyalinization and basal membrane hyalinization in the right testis when compared to the varicocele-bearing left testis (P < .05). We found positive correlations between Johnsen and Agger score of varicocele-bearing left testis and preoperative normally configured motile sperm counts (Pearson's r = .34 and P < .05 and Pearson's r = .41 and P < .05, respectively). The Leydig cell score of varicocele-bearing testis correlated inversely with sperm counts (Pearson's r = -0.37, P < .05). CONCLUSION: These observations may prove of prognostic value in infertile or subfertile men with varicocele.

Uygur MC; Arik AI; Erol D; Ozer E; Ustün H

1999-05-01

88

[Study on the scores of blood stasis syndrome of acute ischemic stroke and its correlation with TOAST subtypes].  

UK PubMed Central (United Kingdom)

UNLABELLED: OBJECTIVE To compare the differences in the scores of blood stasis syndrome (BSS) in three subtypes of acute ischemic stroke (AIS) based on modified Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria, and to explore the influencing factors of BSS. METHODS: Patients with AIS were classified by modified TOAST criteria. The BSS score was determined in 418 patients of atherosclerosis thrombosis (AT), cardioembolism (CE), and small artery disease (SAD) subtypes. The BSS scores were compared in the three subtypes. Univariate analysis and multivariable Logistic analysis were carried out to analyze the influencing factors of BSS. RESULTS: As for the BSS score, CE (120.08 +/- 14.91) > AT (79.56 +/- 11.43) > SAD (37.88 +/- 8.32), and there was statistical difference among different subtypes (P < 0.01). Univariate analysis indicated that age, heart disease, carotid stenosis, NIHSS, GCS, and multiple infarction positions had significant effects on BSS. Multiple Logistic regression analysis suggested that age (OR: 1.71, 95% CII: 1.13-2.74, P = 0.034), heart disease (OR: 2.05,95% CI: 1.52-4.15, P = 0.000), carotid stenosis (OR: 2.74, 95% CI: 1.65-4.55, P = 0.007), and multiple infarction positions (OR: 3.46, 95% CI: 2.16-6.62, P = 0.005) were independent influen cing factors of BSS. CONCLUSIONS: Different TOAST subtypes of BSS had different BSS scores, which was helpful to indicate the reasons for BSS. Age, heart disease, carotid stenosis, and multiple infarction positions were independent influencing factors of BSS.

Tang H; Gu BL; Zhou XM

2012-11-01

89

T2-weighted MRI in Parkinson's disease; Substantia nigra pars compacta hypointensity correlates with the clinical scores  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Iron accumulation in substantia nigra pars compacta (SNpc) and related intensity and volumetric changes in patients with idiopathic Parkinson's disease (PD) has been reported previously. There are only a few studies evaluating the relation between neuroradiological findings and clinical scores, with contradictory results. Aims: In this study we aimed to measure the iron-rich brain areas of PD patients and healthy subjects with T2-weighted magnetic resonance imaging (MRI) and to evaluate the relation between the clinical scores of PD patients and these imaging results. Methods and Materials: T2-weighted MRI findings were studied in 20 patients with PD and 16 healthy controls. The width of SNpc, putamen volume, and the intensity of the basal ganglia were measured. Unified Parkinson's Disease Rating Scale (UPDRS) was used for evaluating the clinical status. Statistical Analyses: Mann Whitney U test for group comparisons, Wilcoxon sign rank test for comparisons within the patient group, and Spearman's rank correlation coefficient for analyses of correlations were used. Results: Mean SNpc and dentate nucleus intensities were lower in PD patients than healthy subjects. Mean SNpc width and putamen volumes were lower in patients. Decrease in the intensity of mean SNpc correlated with high UPDRS and rigidity scores. Conclusion: The results of our study reflect the increase in iron accumulation and oxidative stress in the SNpc in Parkinson's disease. The decrease in the intensity of SNpc correlates with poor clinical scores.

Atasoy Huseyin Tugrul; Nuyan Oguz; Tunc Tugba; Yorubulut Mehmet; Unal Aysun; Inan Levent

2004-01-01

90

Preprocurement pancreas allocation suitability score does not correlate with long-term pancreas graft survival.  

UK PubMed Central (United Kingdom)

BACKGROUND: Within recent years, more marginal donors have been offered to Eurotransplant. To help identify suitable pancreas donors, the Eurotransplant Pancreas Advisory Committee introduced a donor score system (P-PASS). Little is known about the influence of P-PASS on long-term pancreas graft survival. METHODS: From June 1994 to September 2009, we performed 405 pancreas transplantations. In a retrospective study we analyzed P-PASS in 318 cases. Pancreas grafts from donors with P-PASS < 17 (n = 146) analyzed for graft and patient survival as well as for surgical complications were compared with donors of a PASS > or = 17 (n = 172). The mean follow-up was 7.2 +/- 4.3 years. RESULTS: Recipient characteristics were comparable in both groups. Mean P-PASS was 16.7 +/- 2.7 for both groups: 14.3 +/- 1.5 for P-PASS < 17 and 18.8 +/- 1.6 for P-PASS > or = 17. Pancreas graft survival rates for 1, 5, and 10 years were 85%, 77%, and 73% among P-PASS < 17 and 81%, 73%, and 64% among P-PASS > or = 17 groups (P = .12). There were 12 (8.2%) cases of venous thrombosis in the <17 group and 22 (12.7%) in the > or =17 group (P < .05). The relaparotomy rate was significant higher (38.7% vs 28.7%) and duration of hospital treatment longer (40.2 vs 32 days) in the P-PASS > or = 17 group (P < .05). There was no significant difference in patient or kidney graft survival between groups. CONCLUSIONS: The data demonstrated that utilization of pancreas grafts from donors with a P-PASS > or = 17 resulted in good overall outcomes and could expand the organ donor pool. There was no correlation between P-PASS and long-term patient or graft outcome. Complications requiring relaparotomy were more frequent among patients after transplantation from donors with higher P-PASS.

Schenker P; Vonend O; Ertas N; Wunsch A; Viebahn R

2010-01-01

91

Correlation study between KSS, WOMAC and SF-36 scores in patients undergoing total knee arthroplasty in a Spanish speaking population.  

UK PubMed Central (United Kingdom)

The aim of this study was to determine whether it is necessary to use the KSS, WOMAC and SF-36 scales in a Spanish speaking population. These 3 questionnaires were administered to 1000 consecutive patients in the TKA preoperative period. Pearson's correlation coefficient and coefficient of determination were obtained. 196 patients were excluded. A poor correlation was obtained comparing the different items of the different scores with each other. Only in 3 out of different comparisons performed was a Pearson's correlation r>0.5 obtained. The worst results were obtained comparing the two knee specific tests (SF-36 vs WOMAC) and the best ones comparing SF-36 and WOMAC scores. Based on these results, the use of the three tests in the TKA preoperative period is recommended in a Spanish speaking population.

Torres-Claramunt R; Leal J; Hinarejos P; Pelfort X; Puig L

2013-06-01

92

Does the pandemic medical early warning score system correlate with disposition decisions made at patient contact by emergency care practitioners?  

UK PubMed Central (United Kingdom)

OBJECTIVE: To assess the performance of the pandemic medical early warning score (PMEWS) in a cohort of adult patients seen in the community by emergency care practitioners (ECP) and its correlation with ECP decision-making to either 'treat and leave' or transfer for hospital assessment. METHODS: Cases attended by ECP in South Yorkshire in 2007 in which the final ECP working diagnosis was a respiratory condition were retrospectively identified from the Yorkshire Ambulance Service database. The patient report forms were reviewed for the PMEWS variables and scores calculated using the PMEWS system. The outcome measure was management in the community versus transport to hospital. Receiver operating characteristics (ROC) curves were calculated to assess the discrimination of PMEWS. RESULTS: A cohort of 300 patients was assessed. 217 (72%) were aged 65 years or over, and 272 (91%) had either comorbid disease or impaired functional status. 98 (33%) were deemed to need hospital assessment or admission. The ROC curves suggested that there is good correlation between the PMEWS score and the decision to discharge. CONCLUSIONS: PMEWS correlates well with decisions to admit to hospital or leave at home made by extended role practitioners in the patient group studied; however, further prospective work is required to further validate early warning scoring systems in prehospital care.

Gray JT; Challen K; Oughton L

2010-12-01

93

Efficacy of HUMN criteria for scoring the micronucleus assay in human lymphocytes exposed to a low concentration of p,p'-DDT  

Directory of Open Access Journals (Sweden)

Full Text Available The cytokinesis-block micronucleus (CBMN) assay is one of the standard cytogenetic tools employed to assess chromosomal damage subsequent to exposure to genotoxic/cytotoxic agents, and is widely applicable to plant, animal and human cells. In the present study, the CBMN assay was used to assess the baseline damage in binuclear human peripheral blood lymphocytes exposed to 25 µg/L p,p'-DDT for 1, 2, 24, and 48 h by measuring the frequency of micronuclei, nucleoplasmic bridges and nuclear buds. These new scoring criteria facilitated the detection of different types of clastogenic and aneugenic effects induced by this type of pollutant. With these criteria, CBMN can also be used to measure nucleoplasmic bridges which are considered to be consequences of chromosome rearrangements and nuclear buds which are biomarkers of altered gene amplification and gene dosage. The total number of micronuclei observed in binuclear human peripheral blood lymphocytes of the exposed samples (ranging from 32 to 47) was significantly greater (P < 0.05) than that detected in the unexposed (0 time) control sample, where the total number of micronuclei was 7. The number of nucleoplasmic bridges and nuclear buds obtained after 24 and 48 h was also significantly (P < 0.05) greater in the samples treated with p,p'-DDT than in the unexposed control samples. Thus, our results confirmed the usefulness of the new criteria applicable for the CBMN assay employed in measuring the DNA damage and its role of a sensitive cytogenetic biomarker.

V. Garaj-Vrhovac; G. Gajski; S. Ravli?

2008-01-01

94

Radiological evaluation of chronic hemophilic arthropathy by the Pettersson score: Problems in correlation in adult patients  

International Nuclear Information System (INIS)

[en] This study deals with the distribution and extent of hemophilic arthropathy (HA) in 52 adult patients suffering from severe hemophilia A. A clinical and radiological evaluation was undertaken and the results were compared. The limitations of the currently used radiological scoring system are discussed. (orig.)

1988-01-01

95

Color/power Doppler transrectal US in prostate cancer: Correlation with Gleason score  

Energy Technology Data Exchange (ETDEWEB)

To evaluate the relationship between hypervascularity on color/power Doppler transrectal ultrasonography and the Gleason score of corresponding biopsied specimen in patients with prostatic cancer. From July 1998 to March 2002, one hundred fifty seven patients with pathologically proven prostate cancer at this institution were included, and all of them underwent transrectal ultrasonographic examination. Initially, ultrasonographic findings and pathologic data of 129 patients were retrospectively reviewed and excluded 28 patients whose sonographic images were either unavailable or inconclusive. The presence of hypoechoic lesion on transrectal sonography and hypervascularity on color/power Doppler sonography in the peripheral zone of the prostate was first evaluated, and these sonographic findings and Gleason score of the corresponding biopsied specimen were then compared. Statistical analysis was done by Student t-test using SPSS package. Among one hundred twenty nine patients, ninety four patients had a hypoechoic lesion on gray scale sonography while sixty one showed a hypervascular lesion on color/power Doppler sonography. Fifty seven of 61 patients (93.4%) had hypoechoic lesion on gray scale sonography. The mean Gleason score of patients with hypervascular lesion was 7.9 {+-} 0.98 whereas that of the patients without hypervascular lesion, 6.9 {+-} 1.22, showing a statistically significant difference (p<0.01). Prostate cancer with hypervascularity on transrectal sonography appears to have a higher Gleason score on pathologic examination than that without hypervascularity.

Kim, Hyo Cheol; Kim, Seung Hyup; Moon, Min Hoan; Park, Byung Kwan; Kim, Keon Ha; Choi, Hyuck Jae; Yoon, Chang Jin [Seoul National University College of Medicine, Institude of Radiation Medicine, SNUMRC, Seoul (Korea, Republic of)

2002-09-15

96

Radiological evaluation of chronic hemophilic arthropathy by the Pettersson score: Problems in correlation in adult patients  

Energy Technology Data Exchange (ETDEWEB)

This study deals with the distribution and extent of hemophilic arthropathy (HA) in 52 adult patients suffering from severe hemophilia A. A clinical and radiological evaluation was undertaken and the results were compared. The limitations of the currently used radiological scoring system are discussed. (orig.)

Hamel, J.; Pohlmann, H.; Schramm, W.

1988-01-01

97

Contrast-enhanced ultrasonography for the detection and characterization of prostate cancer: Correlation with microvessel density and Gleason score  

Energy Technology Data Exchange (ETDEWEB)

Aim: To determine whether there is a correlation between the peak intensity of the lesion at contrast-enhanced ultrasonography and the microvessel density (MVD) and Gleason score in biopsy specimens of prostate cancer. Materials and methods: Contrast-enhanced ultrasonography using cadence-contrast pulse sequence (CPS) technology was performed in 147 patients with suspected prostate cancer before biopsy. An auto-tracking contrast quantification (ACQ) software was used to analyse the peak intensity (PI) of the lesion. The Gleason score and MVD immunoreactivity were determined in the prostate biopsy specimens. Ultrasound findings were correlated with biopsy findings. Results: Prostate cancer was detected in 73 of 147 patients. The PI values of prostate cancer patients were significantly higher than those of non-malignant patients [9.81 (4.23) versus 5.69 (3.19) dB; p < 0.01]. The mean (SD) PIs of prostate cancer lesions with a Gleason score of 6-9 were 7.08 (3.80), 8.65 (4.08), 9.76 (3.75), and 9.85 (4.13) dB, respectively. The PI value increased significantly with a higher Gleason score (p < 0.01). The mean (SD) MVDs observed in prostate cancer lesions with a Gleason score of 6-9 were 52.50 (10.54), 56.85 (10.31), 59.91 (9.29), and 66.04 (11.82), respectively. There was a positive correlation between PI and MVD in prostate cancer, with a correlation coefficient of 0.617. No correlation was found between PI value and age, prostate specific antigen (PSA) or prostate specific antigen density (PSAD) level (p > 0.05). Conclusion: The PI obtained by CPS harmonic ultrasonography appears to be of value as an indicator of MVD and increases with a higher Gleason score. CPS harmonic ultrasonography could be promising as a useful imaging technique in the detection and characterization of prostate cancer.

Jiang, J. [Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092 (China); Chen, Y., E-mail: joychen_1266@163.com [Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092 (China); Zhu, Y.; Yao, X.; Qi, J. [Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092 (China)

2011-08-15

98

Advanced taste sensors based on artificial lipids with global selectivity to basic taste qualities and high correlation to sensory scores.  

UK PubMed Central (United Kingdom)

Effective R&D and strict quality control of a broad range of foods, beverages, and pharmaceutical products require objective taste evaluation. Advanced taste sensors using artificial-lipid membranes have been developed based on concepts of global selectivity and high correlation with human sensory score. These sensors respond similarly to similar basic tastes, which they quantify with high correlations to sensory score. Using these unique properties, these sensors can quantify the basic tastes of saltiness, sourness, bitterness, umami, astringency and richness without multivariate analysis or artificial neural networks. This review describes all aspects of these taste sensors based on artificial lipid, ranging from the response principle and optimal design methods to applications in the food, beverage, and pharmaceutical markets.

Kobayashi Y; Habara M; Ikezazki H; Chen R; Naito Y; Toko K

2010-01-01

99

Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores  

Directory of Open Access Journals (Sweden)

Full Text Available Effective R&D and strict quality control of a broad range of foods, beverages, and pharmaceutical products require objective taste evaluation. Advanced taste sensors using artificial-lipid membranes have been developed based on concepts of global selectivity and high correlation with human sensory score. These sensors respond similarly to similar basic tastes, which they quantify with high correlations to sensory score. Using these unique properties, these sensors can quantify the basic tastes of saltiness, sourness, bitterness, umami, astringency and richness without multivariate analysis or artificial neural networks. This review describes all aspects of these taste sensors based on artificial lipid, ranging from the response principle and optimal design methods to applications in the food, beverage, and pharmaceutical markets.

Yoshikazu Kobayashi; Masaaki Habara; Hidekazu Ikezazki; Ronggang Chen; Yoshinobu Naito; Kiyoshi Toko

2010-01-01

100

Severity assessment of pulmonary embolism using dual energy CT - correlation of a pulmonary perfusion defect score with clinical and morphological parameters of blood oxygenation and right ventricular failure  

International Nuclear Information System (INIS)

To correlate a Dual Energy (DE)-based visual perfusion defect scoring system with established CT-based and clinical parameters of pulmonary embolism (PE) severity. In 63 PE patients, DE perfusion maps were visually scored for perfusion defects (P-score). Vascular obstruction was quantified using the Mastora score. Both scores were correlated with short-axis diameters of the right and left ventricle, their ratio (RV/LV ratio), width of the pulmonary trunk, a number of clinical parameters and each other. Univariate and multivariate analyses were performed. Times to generate both scores were recorded. After univariate and multivariate analysis, a significant (p 2 (r = -0.50). For the left ventricular diameter, only univariate analysis showed a significant correlation. Mastora score correlated significantly with RV/LV ratio (r = 0.36), width of the pulmonary trunk (r = 0.27), PaO2 (r = -0.41) and troponin I (r = 0.37). Mean time for generating the P-score was significantly shorter than for the Mastora score. A DE-based P-score correlates with a number of parameters of PE severity. It might be easier and faster to perform than some traditional CT scoring methods for vascular obstruction. (orig.)

2012-01-01

 
 
 
 
101

Efficacy of HUMN criteria for scoring the micronucleus assay in human lymphocytes exposed to a low concentration of p,p'-DDT  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english The cytokinesis-block micronucleus (CBMN) assay is one of the standard cytogenetic tools employed to assess chromosomal damage subsequent to exposure to genotoxic/cytotoxic agents, and is widely applicable to plant, animal and human cells. In the present study, the CBMN assay was used to assess the baseline damage in binuclear human peripheral blood lymphocytes exposed to 25 µg/L p,p'-DDT for 1, 2, 24, and 48 h by measuring the frequency of micronuclei, nucleoplasmic bri (more) dges and nuclear buds. These new scoring criteria facilitated the detection of different types of clastogenic and aneugenic effects induced by this type of pollutant. With these criteria, CBMN can also be used to measure nucleoplasmic bridges which are considered to be consequences of chromosome rearrangements and nuclear buds which are biomarkers of altered gene amplification and gene dosage. The total number of micronuclei observed in binuclear human peripheral blood lymphocytes of the exposed samples (ranging from 32 to 47) was significantly greater (P

Garaj-Vrhovac, V.; Gajski, G.; Ravlić , S.

2008-06-01

102

Relationship between overactive bladder and irritable bowel syndrome: a large-scale internet survey in Japan using the overactive bladder symptom score and Rome III criteria.  

UK PubMed Central (United Kingdom)

UNLABELLED: WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: There is known to be an association between overactive bladder (OAB) and irritable bowel syndrome (IBS). The study investigates the association between OAB and IBS using an internet-based survey in Japan. It is the first to investigate the prevalence and severity of OAB in the general population using the OAB symptom score questionnaire. OBJECTIVE: To investigate the association between overactive bladder (OAB) and irritable bowel syndrome (IBS) by using an internet-based survey in Japan. SUBJECTS AND METHODS: Questionnaires were sent via the internet to Japanese adults. The overactive bladder symptom score was used for screening OAB, and the Japanese version of the Rome III criteria for the diagnosis of IBS was used for screening this syndrome. RESULTS: The overall prevalence of OAB and IBS was 9.3% and 21.2%, respectively. Among the subjects with OAB, 33.3% had concurrent IBS. The prevalence of OAB among men was 9.7% and among women it was 8.9%, while 18.6% of men and 23.9% of women had IBS. Concurrent IBS was noted in 32.0% of men and 34.8% of women with OAB. CONCLUSION: Taking into account a high rate of concurrent IBS in patients with OAB, it seems to be important for physicians to assess the defaecation habits of patients when diagnosing and treating OAB.

Matsumoto S; Hashizume K; Wada N; Hori J; Tamaki G; Kita M; Iwata T; Kakizaki H

2013-04-01

103

Quantification of Emphysema with a Three-Dimensional Chest CT Scan: Correlation with the Visual Emphysema Scoring on Chest CT, Pulmonary Function Tests and Dyspnea Severity  

Energy Technology Data Exchange (ETDEWEB)

We wanted to prospectively evaluate the correlation between the quantification of emphysema using 3D CT densitometry with the visual emphysema score, pulmonary function tests (PFT) and the dyspnea score in patients with chronic obstructive pulmonary disease (COPD). Non-enhanced chest CT with 3D reconstruction was performed in 28 men with COPD (age 54-88 years). With histogram analysis, the total lung volume, mean lung density and proportion of low attenuation lung volume below predetermined thresholds were measured. The CT parameters were compared with the visual emphysema score, the PFT and the dyspnea score. A low attenuation lung volume below -950 HU was well correlated with the DLco and FEV{sub 1}/FVC. A Low attenuation lung volume below -950 HU and -930 HU was correlated with visual the emphysema score. A low attenuation lung volume below -950 HU was correlated with the dyspnea score, although the correlations between the other CT parameters and the dyspnea score were not significant. Objective quantification of emphysema using 3D CT densitometry was correlated with the visual emphysema score. A low attenuation lung volume below -950 HU was correlated with the DLco, the FEV{sub 1}/FVC and the dyspnea score.

Park, Hyun Jeong; Hwang, Jung Hwa [Dept. of Radiology, Soonchunhyang University Seoul Hospital, Seoul (Korea, Republic of)

2011-09-15

104

Correlating PSA, bone scan and Gleason score in prostate cancer patients  

International Nuclear Information System (INIS)

The hypothesis was that Gleason Score was more important than PSA in predicting bone metastases in prostate cancer patients. The objective of the work was to identify a group of low risk in which bone scan could be omitted. Clinical records of 165 patients with recently diagnosed prostate cancer, who had had, between January of 1993 and December of 1995, bone scans, PSA and Gleason determinations, were reviewed. 5,5% had well differentiated cancer. 49,7% had a negative bone scan. The risk of bone metastases in spite of levels of PSA

2004-01-01

105

Correlation between Grades in the Medical Basic Science Course and Scores on the Comprehensive Basic Sciences Exam in Iran  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Medical students in Iran are required to undertake a Basic Sciences Comprehensive Exam (BSCE) at the end of their BS course in order to progress to the next stage of medical education. BSCE results are widely used to evaluate medical education programs among different medical universities. The aim of this study is to explore the correlation between BSCE results and students’ mean BS course scores.Methods: A cross-sectional study, using secondary data analysis, was carried out in 2007 in Hormozgan University of Medical Sciences (HUMS) in Iran. Data from the 20th BSCE (held in 1998) to the 36th BSCE (held in 2006) was collected. All medical students who took these exams and for whom the mean results of the BS course and the BSCE were available were eligible for inclusion in the study. For each medical student, data were obtained regarding age at the time of participation in BSCE, together with sex, entrance year, zone as categorised by the national quota system, mean BS course scores, BSCE result, duration of BS course (number of semesters) and number of failed semesters. Students whose data was not complete were excluded from the study. Data was analysed by using SPSS 15 (SPSS Inc., Chicago, Illinois, USA) software.Results: 372 students undertook the BSCE during the research study period. Complete data was available for 365 medical students (98.1%). Among the participants, 224 (61.4%) were female and 141 (38.6%) were male. The mean age at the time of sitting the BSCE was 22.01±1.22. Mean BSCE scores were higher among students who had not previously failed a semester and who also finished the BS course within five semesters. Students with higher BS course scores had higher BSCE scores (P=0.000).Conclusions: Students’ BS course scores were found to correlate to BSCE results. Hence it may be prudent to identify medical students with low BS course scores, in order to provide additional educational support to improve their medical knowledge and thereby enhance their performance on the BSCE.

Hamidreza Mahboobi; Ebrahim Khajeh; Nazanin Sharif; Zahra Jahangiri; Tahereh Khorgoei; Keramat Allah Jahanshahi; Mohammad Esmaeil Shahrzad; Elizabeth Cottrell

2010-01-01

106

Contrast-enhanced ultrasonography for the detection and characterization of prostate cancer: Correlation with microvessel density and Gleason score  

International Nuclear Information System (INIS)

Aim: To determine whether there is a correlation between the peak intensity of the lesion at contrast-enhanced ultrasonography and the microvessel density (MVD) and Gleason score in biopsy specimens of prostate cancer. Materials and methods: Contrast-enhanced ultrasonography using cadence-contrast pulse sequence (CPS) technology was performed in 147 patients with suspected prostate cancer before biopsy. An auto-tracking contrast quantification (ACQ) software was used to analyse the peak intensity (PI) of the lesion. The Gleason score and MVD immunoreactivity were determined in the prostate biopsy specimens. Ultrasound findings were correlated with biopsy findings. Results: Prostate cancer was detected in 73 of 147 patients. The PI values of prostate cancer patients were significantly higher than those of non-malignant patients [9.81 (4.23) versus 5.69 (3.19) dB; p 0.05). Conclusion: The PI obtained by CPS harmonic ultrasonography appears to be of value as an indicator of MVD and increases with a higher Gleason score. CPS harmonic ultrasonography could be promising as a useful imaging technique in the detection and characterization of prostate cancer.

2011-01-01

107

Severity assessment of pulmonary embolism using dual energy CT - correlation of a pulmonary perfusion defect score with clinical and morphological parameters of blood oxygenation and right ventricular failure  

Energy Technology Data Exchange (ETDEWEB)

To correlate a Dual Energy (DE)-based visual perfusion defect scoring system with established CT-based and clinical parameters of pulmonary embolism (PE) severity. In 63 PE patients, DE perfusion maps were visually scored for perfusion defects (P-score). Vascular obstruction was quantified using the Mastora score. Both scores were correlated with short-axis diameters of the right and left ventricle, their ratio (RV/LV ratio), width of the pulmonary trunk, a number of clinical parameters and each other. Univariate and multivariate analyses were performed. Times to generate both scores were recorded. After univariate and multivariate analysis, a significant (p < 0.05) correlation with the P-score was shown for the Mastora score (r = 0.65), RV/LV ratio (r = 0.47), width of the pulmonary trunk (r = 0.26), troponin I (r = 0.43) and PaO{sub 2} (r = -0.50). For the left ventricular diameter, only univariate analysis showed a significant correlation. Mastora score correlated significantly with RV/LV ratio (r = 0.36), width of the pulmonary trunk (r = 0.27), PaO{sub 2} (r = -0.41) and troponin I (r = 0.37). Mean time for generating the P-score was significantly shorter than for the Mastora score. A DE-based P-score correlates with a number of parameters of PE severity. It might be easier and faster to perform than some traditional CT scoring methods for vascular obstruction. (orig.)

Thieme, Sven F. [Ludwig-Maximilians-Universitaet, Department of Clinical Radiology, Muenchen (Germany); Institut fuer Klinische Radiologie der LMU Muenchen, Muenchen (Germany); Ashoori, Nima; Bamberg, Fabian; Sommer, Wieland H.; Johnson, Thorsten R.C.; Maxien, Daniel; Helck, Andreas D.; Reiser, Maximilian F.; Nikolaou, Konstantin [Ludwig-Maximilians-Universitaet, Department of Clinical Radiology, Muenchen (Germany); Leuchte, Hanno; Becker, Alexander [Ludwig-Maximilians-Universitaet, Department of Medicine I, Muenchen (Germany); Behr, Juergen [Ludwig-Maximilians-Universitaet, Department of Medicine I, Muenchen (Germany); Berufsgenossenschaftliches Universitaetsklinikum Bergmannsheil GmbH Ruhr-Universitaet Bochum, Department of Medicine III, Bochum (Germany)

2012-02-15

108

The Correlation of Brody High Resolution Computed Tomography Scoring System with Clinical Status and Pulmonary Function Test in Patients with Cystic Fibrosis  

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Full Text Available Background: To reduce the mortality and morbidity rates of cystic fibrosis (CF) patients, and to have an effective clinical management, it is important to monitor the progression of the disease. The aim of this study was to evaluate the progression of lung disease in CF patients by means of assessing the correlation of the CT scoring system with clinical status and pulmonary function test at the Pediatric Pulmonary Ward of Masih Daneshvari Hospital in 2008. Methods: Pulmonary high resolution computed tomography (HRCT) was performed in 23 CF patients using the Brody's scoring system. Morphologic signs as well as the extent and severity of each sign were scored, and the total score was calculated. The correlation of HRCT scores (total score as well as the score for each parameter) with Shwachman Kuczycki scoring system and pulmonary function test were examined. Results: The study included 9 female and 14 male patients with an age range of 5-23 years (mean: 13.42 years). Bronchiectasis (100%) and peribronchial wall thickening (100%) were the most frequent CT abnormalities. Mucus plugging, air trapping and parenchymal involvements were respectively seen in 95.7%, 91.3% and 47.8% of patients. The overall CT score for all patients was 57.6±24.2 (means±SD). The results of pulmonary function test showed a restrictive pattern; however, in 5.3% of the patients PFT was normal. The overall Shwachman-Kulczycki score was 53.48±13.8. There was a significantly (P=0.015) negative correlation between the total CT score and Shwachman-Kulczycki score; however, there was no significant correlation between total CT score and the results of PFT (P=0.481). Conclusion: The Brody's scoring system for high resolution computed tomography seems to be a sensitive and efficient method to evaluate the progression of CF, and can be more reliable when we combine the CT scores with clinical parameters

Soheila Khalilzadeh; Shahram Kahkouee; Maryam Hassanzad; Nazanin Parsanejad; Nooshin Baghaie; Mohammad Reza Bloorsaz

2011-01-01

109

Correlation of foot bimalleolar angle with Pirani score to assess the severity of congenital talipes equinovarus deformity.  

Science.gov (United States)

Various reported scores for congenital talipes equinovarus are presented with observer variations and lack in objective evidence of severity of deformity. Anteromedial foot bimalleolar angle (FBM), an objective assessment of deformity and correction, was correlated and compared with Pirani scores 0.5-2, 2.5-4, 4.5-6 as grouped I to III for mean and SD in 244 club feet in 137 children. The mean FBM angles of groups I to III were 79.72°, 68.4°, and 53.27°, respectively. The FBM angle gives an objective assessment of the severity of deformity and can be used as objective evidence of improvement/deterioration of deformity. PMID:21912337

Jain, Pragya; Mehtani, Anil; Goel, Meenakshi; Jain, Saurabh; Sood, Alok; Kumar Jain, Anil

2012-01-01

110

Correlation of foot bimalleolar angle with Pirani score to assess the severity of congenital talipes equinovarus deformity.  

UK PubMed Central (United Kingdom)

Various reported scores for congenital talipes equinovarus are presented with observer variations and lack in objective evidence of severity of deformity. Anteromedial foot bimalleolar angle (FBM), an objective assessment of deformity and correction, was correlated and compared with Pirani scores 0.5-2, 2.5-4, 4.5-6 as grouped I to III for mean and SD in 244 club feet in 137 children. The mean FBM angles of groups I to III were 79.72°, 68.4°, and 53.27°, respectively. The FBM angle gives an objective assessment of the severity of deformity and can be used as objective evidence of improvement/deterioration of deformity.

Jain P; Mehtani A; Goel M; Jain S; Sood A; Kumar Jain A

2012-01-01

111

Objective motion sensor assessment highly correlated with scores of global levodopa-induced dyskinesia in Parkinson's disease.  

UK PubMed Central (United Kingdom)

Background: Chronic use of medication for treating Parkinson's disease (PD) can give rise to peak-dose dyskinesia. Adjustments in medication often sacrifice control of motor symptoms, and thus balancing this trade-off poses a significant challenge for disease management. Objective: To determine whether a wrist-worn motion sensor unit could be used to ascertain global dyskinesia severity over a levodopa dose cycle and to develop a severity scoring algorithm highly correlated with clinician ratings. Methods: Fifteen individuals with PD were instrumented with a wrist-worn motion sensor unit, and data were collected with arms in resting and extended positions once every hour for three hours after taking a levodopa dose. Two neurologists blinded to treatment status viewed subject videos and rated global and upper extremity dyskinesia severity based on the modified Abnormal Involuntary Movement Scale (mAIMS). Linear regression models were developed using kinematic features extracted from motion sensor data and extremity, global, or combined (average of extremity and global) mAIMS scores. Results: Dyskinesia occurring during a levodopa dose cycle was successfully measured using a wrist-worn sensor. The logarithm of the power spectrum area between 0.3-3 Hz and the combined clinician scores resulted in the best model performance, with a correlation coefficient between clinician and model scores of 0.81 and root mean square error of 0.55, both averaged across the arms resting and extended postures. Conclusions: One sensor unit worn on either hand can effectively predict global dyskinesia severity during the arms resting or extended positions.

Mera TO; Burack MA; Giuffrida JP

2013-01-01

112

Objective motion sensor assessment highly correlated with scores of global levodopa-induced dyskinesia in Parkinson's disease.  

Science.gov (United States)

Background: Chronic use of medication for treating Parkinson's disease (PD) can give rise to peak-dose dyskinesia. Adjustments in medication often sacrifice control of motor symptoms, and thus balancing this trade-off poses a significant challenge for disease management. Objective: To determine whether a wrist-worn motion sensor unit could be used to ascertain global dyskinesia severity over a levodopa dose cycle and to develop a severity scoring algorithm highly correlated with clinician ratings. Methods: Fifteen individuals with PD were instrumented with a wrist-worn motion sensor unit, and data were collected with arms in resting and extended positions once every hour for three hours after taking a levodopa dose. Two neurologists blinded to treatment status viewed subject videos and rated global and upper extremity dyskinesia severity based on the modified Abnormal Involuntary Movement Scale (mAIMS). Linear regression models were developed using kinematic features extracted from motion sensor data and extremity, global, or combined (average of extremity and global) mAIMS scores. Results: Dyskinesia occurring during a levodopa dose cycle was successfully measured using a wrist-worn sensor. The logarithm of the power spectrum area between 0.3-3 Hz and the combined clinician scores resulted in the best model performance, with a correlation coefficient between clinician and model scores of 0.81 and root mean square error of 0.55, both averaged across the arms resting and extended postures. Conclusions: One sensor unit worn on either hand can effectively predict global dyskinesia severity during the arms resting or extended positions. PMID:23948993

Mera, Thomas O; Burack, Michelle A; Giuffrida, Joseph P

2013-01-01

113

Objective Motion Sensor Assessment Highly Correlated with Scores of Global Levodopa-Induced Dyskinesia in Parkinson's Disease.  

UK PubMed Central (United Kingdom)

Background: Chronic use of medication for treating Parkinson's disease (PD) can give rise to peak-dose dyskinesia. Adjustments in medication often sacrifice control of motor symptoms, and thus balancing this trade-off poses a significant challenge for disease management. Objective: To determine whether a wrist-worn motion sensor unit could be used to ascertain global dyskinesia severity over a levodopa dose cycle and to develop a severity scoring algorithm highly correlated with clinician ratings. Methods: Fifteen individuals with PD were instrumented with a wrist-worn motion sensor unit, and data were collected with arms in resting and extended positions once every hour for three hours after taking a levodopa dose. Two neurologists blinded to treatment status viewed subject videos and rated global and upper extremity dyskinesia severity based on the modified Abnormal Involuntary Movement Scale (mAIMS). Linear regression models were developed using kinematic features extracted from motion sensor data and extremity, global, or combined (average of extremity and global) mAIMS scores. Results: Dyskinesia occurring during a levodopa dose cycle was successfully measured using a wrist-worn sensor. The logarithm of the power spectrum area between 0.3-3 Hz and the combined clinician scores resulted in the best model performance, with a correlation coefficient between clinician and model scores of 0.81 and root mean square error of 0.55, both averaged across the arms resting and extended postures. Conclusions: One sensor unit worn on either hand can effectively predict global dyskinesia severity during the arms resting or extended positions.

Mera TO; Burack MA; Giuffrida JP

2013-07-01

114

Verifying Hellström-Lindberg score as predictive tool for response to erythropoietin therapy according to the "International Working Group" criteria, in anemic patients affected by myelodysplastic syndrome: a monocentric experience.  

Science.gov (United States)

The Hellström-Lindberg score (HLS) (1997) is designed to predict erythroid response to erythropoietin treatment in myelodysplastic patients. In order to test the validity of this scoring system, 58 patients affected by myelodysplastic syndrome, treated with a "standard dose" approach between 2001 and 2010, were analyzed. The response to erythropoietin treatment was evaluated in accordance with the "international working group" (IWG) criteria. Among the patients only two were scored "poor," 12 "intermediate," and 44 "good" (15 of whom were scored "3" and 29 "4"). Although the system was verified as a predictive tool for response to erythropoietin therapy, we noted that of patients scored as "good," those with a numerical score of "4" responded more frequently than did those scored "3", as evaluated under both the 2006- and 2000-IWG ("major response") criteria. The modest response rate in patients scoring "3" did not show a difference in response rate in comparison to the "intermediate" group. The present data suggest that only patients scoring "4" on the scale may show an adequate response to the standard dose erythropoietin therapy, while frontline high-dose therapy should be offered to other patients. A further analysis considering endogenous erythropoietin as a possible determinant of response revealed the optimal cut-off value of 80 mIU/mL, instead of the value of 100 mIU/mL utilized by the HLS. PMID:23508542

Molteni, Alfredo; Riva, Marta; Greco, Rosa; Nichelatti, Michele; Ravano, Emanuele; Marbello, Laura; Nosari, Annamaria; Morra, Enrica

2013-03-19

115

Validation study of portable device for the diagnosis of obstructive sleep apnea according to the new AASM scoring criteria: Watch-PAT 100.  

UK PubMed Central (United Kingdom)

CONCLUSION: Watch-PAT may provide an accurate and clinically effective portable monitoring method for the diagnosis of obstructive sleep apnea (OSA). OBJECTIVE: This study was designed to assess the accuracy and clinical efficacy of a wrist-worn portable device (Watch-PAT 100) to diagnose OSA. METHODS: Twenty-seven participants with suspected OSA underwent full polysomnography (PSG). Finally, 25 subjects successfully underwent portable monitoring using Watch-PAT after full PSG. The study population consisted of 21 males and 4 females, mean age 40.9 +/- 11.2 years (range 21-59). Mean body mass index (BMI) was 26.2 +/- 2.6 kg/m(2) (range 21.2-32.3). All PSG were manually scored according to the new scoring manual of the American Academy of Sleep Medicine (2007) and the Watch-PAT data were analyzed by the automatic algorithm. RESULTS: There was a high correlation of apnea-hypopnea index (AHI) (r = 0.94, p < 0.001) and lowest oxygen saturation (LSAT) (r = 0.90, p < 0.001) between the PSG and the Watch-PAT. A good agreement was also found between PSG AHI, PSG LSAT and PAT AHI, PAT LSAT, respectively. There was a significantly high concordance of the severity of AHI (Kendall tau-b = 0.897, p < 0.001) between the PSG and the Watch-PAT.

Choi JH; Kim EJ; Kim YS; Choi J; Kim TH; Kwon SY; Lee HM; Lee SH; Shin C; Lee SH

2010-07-01

116

Time course of lesion development in patients with acute brain stem infarction and correlation with NIHSS score  

Energy Technology Data Exchange (ETDEWEB)

Background and purpose: diffusion weighted magnetic resonance imaging (MRI) is highly sensitive in detecting acute supratentorial cerebral ischemia and Diffusion Weighted Imaging (DWI) lesion size has been shown to correlate strongly with the neurologic deficit in middle cerebral artery territory stroke. However, data concerning infratentorial strokes are rare. We examined the size and evolution of acute brain stem ischemic lesions and their relationship to neurological outcome. Methods: brain stem infarctions of 11 patients were analyzed. We performed DWI in all patients and in 7/11 patients within 24 h, T2W sequences within the first 2 weeks (10/11 patients) and follow-up MRI (MR2) within 3-9 months (median 4.8 months) later (12/12 patients). Lesion volumes were compared with early and follow-up neurologic deficit as determined by National Institutes of Health Stroke Scale (NIHSS) score. Results: the relative infarct volumes--with MR2 lesion size set to 100%--decreased over the time (P<0.02) with a mean shrinking factor of 3.3 between DWI (MR0) and the follow-up MRT (P<0.02), and 1.6 between early T2W (MR1) and MR2 (P<0.04). The mean DWI volume size (MR0) was larger than the early T2W (P<0.02). Although neurological outcome was good in all patients (mean NIHSS score of 1.3 at follow-up), early NIHSS and follow-up NIHSS scores were strongly correlated (r=0.9, P<0.00). NIHSS score at follow-up was highly correlated with lesion size of DWI (MR0; r=0.71, P<0.04) and T2W of MR1 (r=0.86, P<0.001). Conclusions: in this study, we saw a shrinking of the brain stem infarct volume according to clinical improvement of patients. Great extension of restricted diffusion in the acute stage does not necessarily implicate a large resulting infarction or a bad clinical outcome.

Fitzek, Sabine E-mail: sabine.fitzek@med.uni-jena.de; Fitzek, Clemens; Urban, Peter Paul; Marx, Juergen; Hopf, Hanns Christian; Stoeter, Peter

2001-09-01

117

Distribution of brain infarction in children with tuberculous meningitis and correlation with outcome score at 6 months  

Energy Technology Data Exchange (ETDEWEB)

Prognostic indicators for tuberculous meningitis (TBM) offer realistic expectations for parents of affected children. Infarctions affecting the basal ganglia are associated with a poor outcome. To correlate the distribution of infarction in children with TBM on CT with an outcome score (OS). CT brain scans in children with TBM were retrospectively reviewed and the distribution of infarctions recorded. The degree of correlation with OS at 6 months was determined. There was a statistically significant association between all sites of infarction (P = 0.0001-0.001), other than hemispheric (P = 0.35), and outcome score. There was also a statistically significant association between all types of infarction (P = 0.0001-0.02), other than hemispheric (P = 0.05), and overall poor outcome. The odds ratio for poor outcome with bilateral basal ganglia and internal capsule infarction was 12. The odds ratio for poor outcome with 'any infarction' was 4.91 (CI 2.24-10.74), with 'bilateral infarctions' 8.50 (CI 2.49-28.59), with basal ganglia infarction 5.73 (CI 2.60-12.64), and for hemispheric infarction 2.30 (CI 1.00-5.28). Infarction is associated with a poor outcome unless purely hemispheric. MRI diffusion-weighted imaging was not part of this study, but is likely to play a central role in detecting infarctions not demonstrated by CT. (orig.)

Andronikou, Savvas [University of Stellenbosch, Department of Radiology, Tygerberg Hospital, P.O. Box 19063, Tygerberg (South Africa); Wilmshurst, Jo; Hatherill, Mark [University of Cape Town, Pediatric Neurology, Red Cross Children' s Hospital, School of Child and Adolescent Health, Cape Town (South Africa); VanToorn, Ronald [University of Stellenbosch, Department of Pediatric Neurology, Tygerberg Hospital, Cape Town (South Africa)

2006-12-15

118

Correlation between a new visual prostate symptom score (VPSS) and uroflowmetry parameters in men with lower urinary tract symptoms  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english OBJECTIVE: A visual prostate symptom score (VPSS) compared with the international prostate symptom score (IPSS) for evaluation of lower urinary tract symptoms (LUTS) can be completed without physician assistance by a significantly larger proportion of men with limited education. We aimed to evaluate the correlation of the VPSS and IPSS with uroflowmetry parameters. METHODS: Men with LUTS were requested to complete the IPSS and VPSS, consisting of pictograms to evaluate ur (more) inary frequency, nocturia, force of the stream and quality of life. The maximum (Qmax) and average urinary flow rate (Qave), voided volume (VV) and post-void residual (PVR) urine volumes were measured. Statistical analysis was performed using the Mann-Whitney and Spearman's tests. RESULTS: The study included 93 men (mean age 64 years, range 33 -85), with VV >150 ml in 66 (71%) and 150 ml there were significant negative correlations between the IPSS and Qmax (r=-0.30, p=0.016), the IPSS and Qave (r=-0.29, p=0.018), the VPSS and Qmax (r=-0.38, p

Heyns, C F; van der Walt, C L E; Groeneveld, A E

2012-04-01

119

Distribution of brain infarction in children with tuberculous meningitis and correlation with outcome score at 6 months  

International Nuclear Information System (INIS)

[en] Prognostic indicators for tuberculous meningitis (TBM) offer realistic expectations for parents of affected children. Infarctions affecting the basal ganglia are associated with a poor outcome. To correlate the distribution of infarction in children with TBM on CT with an outcome score (OS). CT brain scans in children with TBM were retrospectively reviewed and the distribution of infarctions recorded. The degree of correlation with OS at 6 months was determined. There was a statistically significant association between all sites of infarction (P = 0.0001-0.001), other than hemispheric (P = 0.35), and outcome score. There was also a statistically significant association between all types of infarction (P = 0.0001-0.02), other than hemispheric (P = 0.05), and overall poor outcome. The odds ratio for poor outcome with bilateral basal ganglia and internal capsule infarction was 12. The odds ratio for poor outcome with 'any infarction' was 4.91 (CI 2.24-10.74), with 'bilateral infarctions' 8.50 (CI 2.49-28.59), with basal ganglia infarction 5.73 (CI 2.60-12.64), and for hemispheric infarction 2.30 (CI 1.00-5.28). Infarction is associated with a poor outcome unless purely hemispheric. MRI diffusion-weighted imaging was not part of this study, but is likely to play a central role in detecting infarctions not demonstrated by CT. (orig.)

2006-01-01

120

Can a herpes simplex virus type 1 neuroinvasive score be correlated to other risk factors in Alzheimer's disease?  

UK PubMed Central (United Kingdom)

Herpes simplex virus type 1 (HSV-1) is latent in the nervous system of most humans. Ball [Can J Neurol Sci 9 (1982) 303] first suggested the hypothesis that HSV-1 could be involved in the pathogenesis of Alzheimer's Disease (AD) by noting that regions of the brain particularly and earliest affected in AD were the same as those most damaged during HSV encephalitis. Data from Itzhaki's research suggests that HSV-1 in the brain and the carriage of an apolipoprotein E allele 4 (ApoE e4) together confer risk for AD [J Pathol 97 (2002) 395], [Mol Chem Neuropathol 28 (1996) 135], [Alzheimer's Rep 1 (1998) 173], [Biochem Soc Trans 26 (1998) 273]. Of the two other studies based on Itzhaki's findings, one showed similar results [Lancet 349 (1997) 1102], and the other showed a similar trend [Lancet 351 (1998) 1330], [Lancet 352 (1998) 1312]. To further examine the role of HSV-1 in the etiology of AD, we have formulated a Neuroinvasive Score that quantifies the presence and viral load of HSV-1 in eight brain regions. These regions are: entorhinal cortex, hippocampus, pons, cerebellum, and neocortex (temporal, parietal, occipital, and frontal). We hypothesize that the Neuroinvasive Score that encompasses the presence, amount, and extent of HSV-1 spreading (neuroinvasiveness), will correlate with the genetic risk factor, ApoE e4, in the assessment of autopsy samples from AD patients. If the neuroinvasive score can be directly correlated to the different stages of AD (mild, moderate, severe), this will strengthen the hypothesis that HSV-1 is involved in AD and that ApoE e4 also confers risk for the development and progression of AD.

Hill JM; Gebhardt BM; Azcuy AM; Matthews KE; Lukiw WJ; Steiner I; Thompson HW; Ball MJ

2005-01-01

 
 
 
 
121

Pulmonary Wegener' s granulomatosis. Correlation between high-resolution CT findings and clinical scoring of disease activity  

International Nuclear Information System (INIS)

It has been considered that the treatment to the patient with Wegener granulomatosis (WG) it should be adapted to the activity of the illness. In this work it was looked for to evaluate if the discoveries in the high-resolution tomography of thorax of in several clinical stadiums of the illness were correlated with the clinical score of activity of the illness. 73 patients were studied with WG (30 women, 43 men) with age between 34 and 71 years. They were carried out 98 radiological exams. The pursuit was made with bronchoscopy, BAL, tests of pulmonary function, Rx thorax. The high-resolution tomography was taken before the bronchoscopy and it was the base for the realization of the BAL. Patient with Rx normal thorax they were also included

1999-01-01

122

Genetic risk score does not correlate with body mass index of Latina women in a clinical trial.  

Science.gov (United States)

Obesity disproportionately affects Latina women. Common genetic variants are convincingly associated with body mass index (BMI) and may be used to create genetic risk scores (GRS) for obesity that could define genetically influenced forms of obesity and alter response to clinical trial interventions. The objective of this study was (1) to identify the frequency and effect size of common obesity genetic variants in Latina women; (2) to determine the clinical utility of a GRS for obesity with Latina women participating in a community-based clinical trial. DNA from 85 Latina women was genotyped for eight genetic variants previously associated with BMI in Caucasians, but not yet assessed in Latina populations. The main outcome measure was the correlation of GRS (sum of eight risk alleles) with BMI, waist circumference, and percent body fat. A majority (83%) of participants had a BMI ?25. Frequency of loci near FTO, MC4R, and GNPDA2 were lower in Latinas than Caucasians. Association of each locus with BMI was lower in Latinas compared to Caucasians with no significant correlations with BMI. We conclude that an eight locus GRS has no clinical utility for explaining obesity or predicting response to intervention in Latina women participating in a clinical trial. PMID:22029802

Coenen, Kimberly R; Karp, Sharon M; Gesell, Sabina B; Dietrich, Mary S; Morgan, Thomas M; Barkin, Shari L

2011-10-01

123

Genetic risk score does not correlate with body mass index of Latina women in a clinical trial.  

UK PubMed Central (United Kingdom)

Obesity disproportionately affects Latina women. Common genetic variants are convincingly associated with body mass index (BMI) and may be used to create genetic risk scores (GRS) for obesity that could define genetically influenced forms of obesity and alter response to clinical trial interventions. The objective of this study was (1) to identify the frequency and effect size of common obesity genetic variants in Latina women; (2) to determine the clinical utility of a GRS for obesity with Latina women participating in a community-based clinical trial. DNA from 85 Latina women was genotyped for eight genetic variants previously associated with BMI in Caucasians, but not yet assessed in Latina populations. The main outcome measure was the correlation of GRS (sum of eight risk alleles) with BMI, waist circumference, and percent body fat. A majority (83%) of participants had a BMI ?25. Frequency of loci near FTO, MC4R, and GNPDA2 were lower in Latinas than Caucasians. Association of each locus with BMI was lower in Latinas compared to Caucasians with no significant correlations with BMI. We conclude that an eight locus GRS has no clinical utility for explaining obesity or predicting response to intervention in Latina women participating in a clinical trial.

Coenen KR; Karp SM; Gesell SB; Dietrich MS; Morgan TM; Barkin SL

2011-10-01

124

The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system      and the EORTC quality of life questionnaires  

DEFF Research Database (Denmark)

BACKGROUND AND PURPOSE: Morbidity is an important issue in cancer       research. The observer-based toxicity scoring system used by DAHANCA (the       Danish head and neck cancer study group) has proved itself sensitive to       differences in toxicity in a large randomised study, but like other       toxicity scoring systems it has not been formally validated. Conversely,       the EORTC quality of life questionnaire (QLQ) has been validated as a tool       for collecting information about the consequences of disease and treatment       on the well being of cancer patients. The purpose of this study was to       examine the relationship between the two methods of side effect recording.       PATIENTS AND METHODS: One hundred and sixteen recurrence free patients       with laryngeal (n=44), pharyngeal (n=34) and oral cavity (n=38) cancer       attending follow-up after radiotherapy (n=83) or surgery (n=33) completed       EORTC C30, the core questionnaire concerning general symptoms and function       and EORTC H&N35 the head and neck specific questionnaire. The attending       physicians in the follow-up clinic evaluated and recorded DAHANCA toxicity       scores on the same patients. RESULTS: The DAHANCA toxicity scoring system       and the EORTC QLQ correlated with several clinical endpoints. The       conceptually similar endpoints of the two methods correlated       significantly. The objective endpoints of the DAHANCA scoring system were       only correlated with quality of life endpoints to a very low degree. The       DAHANCA toxicity scores had a low sensitivity (0.48-0.74) in detecting       equivalent subjective complaints from the questionnaires and the       observer-based scoring system severely underestimated patient complaints.       A specific patient group where the DAHANCA score had a higher tendency to       fail could not be detected. CONCLUSION: The DAHANCA toxicity score is an       effective instrument in assessing objective treatment induced toxicity in       head and neck cancer patients but insensitive and non-specific with regard       to patient assessed subjective endpoints. This weakness seems inherent in       an observer-based scoring system, and will probably also apply to newer       ones like CTCAE 3.0

Jensen, Kenneth; Jensen, Anders Bonde

2006-01-01

125

The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system and the EORTC quality of life questionnaires  

International Nuclear Information System (INIS)

Background and purpose: Morbidity is an important issue in cancer research. The observer-based toxicity scoring system used by DAHANCA (the Danish head and neck cancer study group) has proved itself sensitive to differences in toxicity in a large randomised study, but like other toxicity scoring systems it has not been formally validated. Conversely, the EORTC quality of life questionnaire (QLQ) has been validated as a tool for collecting information about the consequences of disease and treatment on the well being of cancer patients. The purpose of this study was to examine the relationship between the two methods of side effect recording. Patients and methods: One hundred and sixteen recurrence free patients with laryngeal (n=44), pharyngeal (n=34) and oral cavity (n=38) cancer attending follow-up after radiotherapy (n=83) or surgery (n=33) completed EORTC C30, the core questionnaire concerning general symptoms and function and EORTC H and N35 the head and neck specific questionnaire. The attending physicians in the follow-up clinic evaluated and recorded DAHANCA toxicity scores on the same patients. Results: The DAHANCA toxicity scoring system and the EORTC QLQ correlated with several clinical endpoints. The conceptually similar endpoints of the two methods correlated significantly. The objective endpoints of the DAHANCA scoring system were only correlated with quality of life endpoints to a very low degree. The DAHANCA toxicity scores had a low sensitivity (0.48-0.74) in detecting equivalent subjective complaints from the questionnaires and the observer-based scoring system severely underestimated patient complaints. A specific patient group where the DAHANCA score had a higher tendency to fail could not be detected. Conclusion: The DAHANCA toxicity score is an effective instrument in assessing objective treatment induced toxicity in head and neck cancer patients but insensitive and non-specific with regard to patient assessed subjective endpoints. This weakness seems inherent in an observer-based scoring system, and will probably also apply to newer ones like CTCAE 3.0.

2006-01-01

126

Correlation of different pollution criteria in the assessment of metal sediment pollution.  

UK PubMed Central (United Kingdom)

In this article an assessment of the sediment metal pollution (cadmium, copper, chromium, lead, nickel, zinc) in the Veliki Backi canal (Serbia) was carried out using pseudo-total metal content, contamination factor (CF), pollution load index (PLI) and enrichment factor (EF). The study also encompassed pore-water metal concentrations and an assessment of sediment pollution based on the analysis of simultaneously extracted metals (SEM), acid volatile sulphides (AVS) and the sequential extraction procedure. The concentrations of metals are likely to result in harmful effects based on the comparison with sediment quality guidelines (Dutch, Canadian, US EPA - United States Environmental Protection Agency). The ratio of simultaneously extracted metals and volatile acid sulphides was found to be greater than 1 in only one location, which is already recognized as a place of high risk based on the criteria applied. Other samples had ?[SEM]/[AVS] < 1, despite their high risk classification based on the applied criteria. According to the sequential extraction procedure, zinc and nickel exhibit high risk in most samples, whereas other metals show low and medium risk. The CF values for Cr, Cu and Zn were > 6 in most samples, which denotes very high contamination by these metals. The PLI values indicated moderate and high pollution. The EF values for all metals studied except for Cd in some cases were >1.5, suggesting anthropogenic impact. The obtained results will be invaluable for future activities regarding sediment monitoring and will facilitate the selection of appropriate criteria when evaluating sediment quality.

Kr?mar D; Prica M; Dalmacija B; Watson M; Tri?kovi? J; Raji? L; Tamaš Z

2013-01-01

127

Correlation of volumetric mismatch and mismatch of Alberta Stroke program Early CT scores on CT perfusion maps  

Energy Technology Data Exchange (ETDEWEB)

We aimed to determine if volumetric mismatch between tissue at risk and tissue destined to infarct on computed tomography perfusion (CTP) can be described by the mismatch of Alberta Stroke Program Early CT Score (ASPECTS). Forty patients with nonlacunar middle cerebral artery infarct <6 h old who had CTP on admission were retrospectively reviewed. Two raters segmented the lesion volume on mean transit time (MTT) and cerebral blood volume (CBV) maps using thresholds of >6 s and <2.0 mL per 100 g, respectively. Two other raters assigned ASPECTS to the same MTT and CBV maps while blinded to the volumetric data. Volumetric mismatch was deemed present if {>=}20%. ASPECTS mismatch (=CBV ASPECTS - MTT ASPECTS) was deemed present if {>=}1. Correlation between the two types of mismatches was assessed by Spearman's coefficient ({rho}). ROC curve analyses were performed to determine the optimal ASPECTS mismatch cut point for volumetric mismatch {>=}20%, {>=}50%, {>=}100%, and {>=}150%. Median volumetric mismatch was 130% (range 10.9-2,031%) with 31 (77.5%) being {>=}20%. Median ASPECTS mismatch was 2 (range 0-6) with 26 (65%) being {>=}1. ASPECTS mismatch correlated strongly with volumetric mismatch with {rho} = 0.763 [95% CI 0.585-0.870], p < 0.0001. Sensitivity and specificity for volumetric mismatch {>=}20% was 83.9% [95% CI 65.5-93.5] and 100% [95% CI 65.9-100], respectively, using ASPECTS mismatch {>=}1. Volumetric mismatch {>=}50%, {>=}100%, and {>=}150% were optimally identified using ASPECTS mismatch {>=}1, {>=}2, and {>=}2, respectively. On CTP, ASPECTS mismatch showed strong correlation to volumetric mismatch. ASPECTS mismatch {>=}1 was the optimal cut point for volumetric mismatch {>=}20%. (orig.)

Lin, Ke; Rapalino, Otto; Lee, Benjamin; Do, Kinh G.; Sussmann, Amado R.; Pramanik, Bidyut K. [NYU Medical Center/Bellevue Hospital, Department of Radiology, New York, NY (United States); Law, Meng [Mount Sinai Medical Center, Department of Radiology, New York, NY (United States)

2009-01-15

128

Correlation of WOMAC and KOOS scores to tibiofemoral cartilage loss on plain radiography and 3 Tesla MRI: data from the osteoarthritis initiative.  

UK PubMed Central (United Kingdom)

PURPOSE: The purpose of this study was to determine the correlation between the Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) and Knee Injury Osteoarthritis Outcomes scores (KOOS) and the degree of tibiofemoral cartilage loss on plain radiography and 3T magnetic resonance imaging (MRI). We hypothesize that these subjective outcome scores will have a significant correlation to quantitative joint space loss. METHODS: Data used in the preparation of this article were obtained from the osteoarthritis initiative (OAI) database (OAI public use data sets kMRI_QCart_Eckstein18 and kXR_QJSW_Duryea16). Four hundred and forty-five patients had WOMAC/KOOS scores, quantitative tibiofemoral joints space width on plain radiographs and quantitative tibiofemoral cartilage thickness and per cent full thickness cartilage loss on 3T MRI. Joint space width on plain radiographs was correlated to cartilage thickness on MRI, and WOMAC/KOOS scores were correlated to the degree of cartilage loss using Pearson correlation coefficients. RESULTS: There was a statistically significant correlation between medial and lateral compartment cartilage thickness on MRI and medial and lateral joint space width on plain radiography (r = 0.86, r = 0.80) (p < 0.001). KOOS knee pain score was significantly correlated to increasing per cent full thickness cartilage loss in the medial femoral compartment (r = 0.34) (p < 0.001). KOOS symptom score was significantly correlated to decreasing joint space width in the medial (r = 0.16) and lateral (r = 0.15) compartment and increasing per cent full thickness cartilage loss in the medial femoral compartment (r = 0.36) (p < 0.001). No WOMAC score was correlated to degree of joint space width, cartilage thickness or per cent full thickness cartilage loss (n.s). CONCLUSION: The WOMAC and KOOS scores are poor indicators of tibiofemoral cartilage loss, with only the KOOS symptom and knee pain score being weakly correlated. Osteoarthritis is a multifactorial process and the need to treat patients based off their symptoms and rely on radiographs as confirmatory modalities, and not diagnostic modalities, when talking about OA and medical intervention. LEVEL OF EVIDENCE: Level 2.

Illingworth KD; El Bitar Y; Siewert K; Scaife SL; El-Amin S; Saleh KJ

2013-01-01

129

Healing of muscle trauma after intramuscular injection of antibiotics in sheep: correlations between clinical, macroscopic and microscopic scores.  

UK PubMed Central (United Kingdom)

The present study aimed to predict the resultant healing from early lesions (found days 3 and 10 post injection) caused by the intramuscular injection of veterinary antibiotic formulations. Nineteen marketed drugs were selected in order to screen a wide range of irritation conditions at the injection site. Nineteen ewes were each injected intramuscularly with one of the formulations. Each injection was at a different site, 3 and 10 days prior to slaughter. Fourteen of these ewes also received intramuscular injections at two other sites 21 and 32 days prior to slaughter. The tolerance was monitored by clinical examination of the injection site and by gross and microscopic pathology. Myodegeneration and fibre necrosis were determined histologically. The clinical scores did not correlate with the other findings. Myodegeneration correlated with the size of the lesion on day 3 post-injection and was not found thereafter. Although occasionally found alone, it was generally associated with and surrounded by fibre necrosis. When myodegeneration was the only lesion, regeneration was complete by day 21 and the fibrosis was minimal or absent. Necrosis at day 10 post-injection correlated with necrosis at days 3, 21 and 32 post-injection. Fibrosis became prominent around the necrotic muscles from day 10 post-injection. Healing from necrosis was slow with, in some instances, encapsulated debris still persisting at day 32 post-injection. The tissue irritation index correlated well with myodegeneration and necrose (acute lesions) and fibrose and necrose (older lesions). Thus, after considering a large sample of antibiotic formulations, this study indicated that healing could be predicted from the muscle fibre histopathology at days 3 and 10 post-injection. If myodegeneration was found alone, full recovery within 21 days could be predicted. If fibre necrosis was extensive, the healing involved encapsulating the necrotic tissues and thus resulted in extensive scar formation. The tissue changes explained why the irritation index of the lesions at days 21 and 32 post-injection could be predicted from their irritation index at days 3 and 10 post-injection. Likewise, the size of the lesion at days 21 and 32 post-injection could not be predicted from its size at day 3 post injection.

Mikaelian I; Poul JM; Cabanié P

1996-01-01

130

Healing of muscle trauma after intramuscular injection of antibiotics in sheep: correlations between clinical, macroscopic and microscopic scores.  

Science.gov (United States)

The present study aimed to predict the resultant healing from early lesions (found days 3 and 10 post injection) caused by the intramuscular injection of veterinary antibiotic formulations. Nineteen marketed drugs were selected in order to screen a wide range of irritation conditions at the injection site. Nineteen ewes were each injected intramuscularly with one of the formulations. Each injection was at a different site, 3 and 10 days prior to slaughter. Fourteen of these ewes also received intramuscular injections at two other sites 21 and 32 days prior to slaughter. The tolerance was monitored by clinical examination of the injection site and by gross and microscopic pathology. Myodegeneration and fibre necrosis were determined histologically. The clinical scores did not correlate with the other findings. Myodegeneration correlated with the size of the lesion on day 3 post-injection and was not found thereafter. Although occasionally found alone, it was generally associated with and surrounded by fibre necrosis. When myodegeneration was the only lesion, regeneration was complete by day 21 and the fibrosis was minimal or absent. Necrosis at day 10 post-injection correlated with necrosis at days 3, 21 and 32 post-injection. Fibrosis became prominent around the necrotic muscles from day 10 post-injection. Healing from necrosis was slow with, in some instances, encapsulated debris still persisting at day 32 post-injection. The tissue irritation index correlated well with myodegeneration and necrose (acute lesions) and fibrose and necrose (older lesions). Thus, after considering a large sample of antibiotic formulations, this study indicated that healing could be predicted from the muscle fibre histopathology at days 3 and 10 post-injection. If myodegeneration was found alone, full recovery within 21 days could be predicted. If fibre necrosis was extensive, the healing involved encapsulating the necrotic tissues and thus resulted in extensive scar formation. The tissue changes explained why the irritation index of the lesions at days 21 and 32 post-injection could be predicted from their irritation index at days 3 and 10 post-injection. Likewise, the size of the lesion at days 21 and 32 post-injection could not be predicted from its size at day 3 post injection. PMID:8721289

Mikaelian, I; Poul, J M; Cabanié, P

1996-01-01

131

Monocyte deactivation correlates with injury severity score, but not with heme oxygenase-1 levels in trauma patients.  

UK PubMed Central (United Kingdom)

Traumatic injury induces a local and systemic release of pro-inflammatory cytokines, acute phase proteins, hormones, and other inflammatory mediators. The excessive release of these mediators plays an important role in the pathogenesis of shock. In parallel to this pro-inflammatory response, there is a regulatory response characterized by the release of anti-inflammatory mediators, which is thought to represent the host's attempt to restore immunological equilibrium. Studies in septic patients have suggested the compensatory anti-inflammatory response may result in an "immunodeficient state" that leaves the host susceptible to further infectious insults. A key feature of the anti-inflammatory state in septic patients is a change in the responsiveness of monocytes that has been termed "monocyte deactivation." This is supported by data that link monocyte deactivation to increased mortality in septic patients. Monocytes with reduced HLA-DR expression have been described in trauma patients. We collected blood from 25 severely injured patients and evaluated peripheral blood mononuclear cells (PBMC) for HLA-DR expression and TNF-? response to LPS stimulation as markers of monocyte deactivation. Levels of intracellular HO-1 were determined in each patient, as HO-1 has been implicated in monocyte deactivation in patients with severe systemic inflammatory response syndrome (SIRS). HLA-DR expression correlated inversely with Injury Severity Scores and TNF-? response to LPS stimulation, but failed to correlate with HO-1 levels in these patients. HLA-DR expression was decreased in normal monocytes stimulated with patient plasma, but this treatment had no effect on HO-1 levels. These results suggest monocyte deactivation in trauma patients is unlikely to be mediated by HO-1.

West SD; Mold C

2012-01-01

132

Evaluation of disease activity in rheumatoid arthritis by Routine Assessment of Patient Index Data 3 (RAPID3) and its correlation to Disease Activity Score 28 (DAS28) and Clinical Disease Activity Index (CDAI): an Indian experience.  

Science.gov (United States)

Serial objective assessment of disease activity in rheumatoid arthritis (RA) is imperative to achieve remission. Routine Assessment of Patient Index Data 3 (RAPID3), an index without formal joint counts, appears attractive for evaluation of disease activity in RA patients in a busy clinical setting. This study aims to evaluate correlation and agreement of RAPID3 with Disease Activity Score 28 (DAS28) and Clinical Disease Activity Index (CDAI) in RA patients. All patients completed a Multidimensional Health Assessment Questionnaire (MDHAQ) at each visit. A physician/assessor 28-joint count and erythrocyte sedimentation rate were completed in 200 literate patients with RA to score DAS28, CDAI, and RAPID3. RAPID3 includes the three MDHAQ patient self-report RA core dataset measures for physical function, pain, and patient global estimate. Proposed RAPID3 (range, 0-30) severity categories of high (>12), moderate (6.1-12.0), low (3.1-6.0), and near remission (?3) were compared to DAS28 (0-10) activity categories of high (> 5.1), moderate (3.21-5.1), low (2.61-3.2), and remission (? 2.6), and CDAI (0-76) categories of >22, 10.1-22.0, 2.9-10.0, and ?2.8. Statistical significance was analyzed using Spearman correlations, cross-tabulations, and kappa statistics. Comparison of RAPID3 with DAS28 and CDAI indicated Spearman rank-order correlation coefficients for DAS28 with RAPID3 of 0.910, and for CDAI with RAPID3 of 0.907, all highly significant (P < 0.001). There was substantial agreement between RAPID3 and DAS28 (kappa value = 0.634, P < 0.001) and also between RAPID3 and CDAI (kappa value = 0.690, P < 0.001). Overall, 89-94 % of patients who met DAS28 or CDAI moderate/high activity criteria met similar RAPID severity criteria and 84-88 % who met DAS28 or CDAI remission/low activity criteria also met similar RAPID criteria. RAPID3 scores provide similar quantitative information to DAS28 and CDAI, and hence, is an informative index for evaluation of disease activity in RA in busy clinical settings. PMID:22983768

Singh, H; Gupta, V; Ray, S; Kumar, H; Talapatra, P; Kaur, M; Kumar, S; Arya, S; Mathur, R; Ghangas, N

2012-09-15

133

Time course of lesion development in patients with acute brain stem infarction and correlation with NIHSS score  

International Nuclear Information System (INIS)

[en] Background and purpose: diffusion weighted magnetic resonance imaging (MRI) is highly sensitive in detecting acute supratentorial cerebral ischemia and Diffusion Weighted Imaging (DWI) lesion size has been shown to correlate strongly with the neurologic deficit in middle cerebral artery territory stroke. However, data concerning infratentorial strokes are rare. We examined the size and evolution of acute brain stem ischemic lesions and their relationship to neurological outcome. Methods: brain stem infarctions of 11 patients were analyzed. We performed DWI in all patients and in 7/11 patients within 24 h, T2W sequences within the first 2 weeks (10/11 patients) and follow-up MRI (MR2) within 3-9 months (median 4.8 months) later (12/12 patients). Lesion volumes were compared with early and follow-up neurologic deficit as determined by National Institutes of Health Stroke Scale (NIHSS) score. Results: the relative infarct volumes--with MR2 lesion size set to 100%--decreased over the time (P

2001-01-01

134

Correlation of Cognition and SPECT Perfusion: Easy Z Score and SPM Analysis of a Pilot Sample with Cerebral Small Vessel Disease.  

UK PubMed Central (United Kingdom)

Background/Aims: To associate neuropsychology test performance with perfusion on single-photon emission computed tomography (SPECT) among 12 patients with cerebral small vessel disease. Methods: The easy Z score imaging system (eZIS) was used to compare patient images to those of normal controls. Scores from neuropsychological tests commonly used to screen for dementia were associated with SPECT resting perfusion image values using the statistical parametric mapping (SPM) program. Results: Immediate Memory and Delayed Memory index scores, as well as memory subtests of the Repeatable Battery for Assessment of Neuropsychological Status showed cluster- and voxelwise positive correlations with hypoperfusion in frontal, temporal and cerebellar regions. Negative correlations, primarily in frontal regions, were interpreted as compensatory hyperperfusion. Conclusion: eZIS and SPM analyses of SPECT images showed perfusion correlations with neuropsychological tests with small vessel disease. © 2013 S. Karger AG, Basel.

Baker JG; Williams AJ; Wack DS; Miletich RS

2013-08-01

135

Proctitis after external-beam radiotherapy for prostate cancer classified by Vienna Rectoscopy Score and correlated with EORTC/RTOG score for late rectal toxicity: Results of a prospective multicenter study of 166 patients  

International Nuclear Information System (INIS)

Purpose: To evaluate the Vienna Rectoscopy Score (VRS) as a feasible and effective tool for detecting and classifying pathologic changes in the rectal mucosa after radiotherapy (RT) for prostate cancer, and, also, to correlate its findings with the European Organization for Research and Treatment of Cancer (EORTC)/Radiation Therapy Oncology Group (RTOG) score for late rectal toxicity. Methods and Materials: A total of 486 patients with localized prostate cancer underwent external-beam RT up to 70 or 74 Gy within an Austrian-German prospective multicenter trial. In 166 patients, voluntary rectal sigmoidoscopy was performed before and at 12 and/or 24 months after RT. Pathologic findings such as telangiectasia, congested mucosa, and ulcers were graded (Grades 0-3) and summarized according to the VRS. Late rectal side effects (EORTC/RTOG) were documented and correlated with the corresponding VRS. Results: Before RT, 99% had a VRS score of 0. The median follow-up was 40 months. Overall, a late rectal side effects grade or score 1-3 was detected in 43% by EORTC/RTOG compared with 68% by VRS (p

2007-01-01

136

Correlation between IQIs- criteria of utilization from the level of required sensitivity  

International Nuclear Information System (INIS)

The correct selection and utilization of the image quality indicators (IQI) is indispensable to assure the detection and allow the dimensioning of the gaps in the radiographic test. Its use by the industries lead to an inadequate use of IQI, distortioning the specifications adopted. From this observations the authors show the essentials parameters of IQIs in a way to facilitate, without quality damage or distortion of specifications, the correlation among the several types. (E.G.)

1983-01-01

137

Could near-infrared Raman spectroscopy be correlated with the METAVIR scores in liver lesions induced by hepatitis C virus?  

Science.gov (United States)

The liver is responsible for several basic functions in human body how the syntheses of the most main proteins and degradation process of toxins, drugs and alcohols. In present days, the viral hepatitis C is one of the highest causes of chronic hepatic illness worldwide, affecting around 3% of the world population. The liver biopsy is considered the gold standard for diagnosing hepatic fibrosis; however, the biopsies may be questioned because of potential sampling error, morbidity, possible mortality and relatively high costs. Spectroscopy techniques such as Raman spectroscopy have been used for diagnosis of human tissues, with favorable results. Raman spectroscopy has been employed to distinguish normal from hepatic lesions through spectral features mainly of proteins, nucleic acids and lipids. In this study, eleven patients with diagnoses of chronic hepatitis C underwent hepatic biopsies having two hepatic fragments collected: one was scored through METAVIR system and the other one was submitted to near-infrared Raman spectroscopy using a dispersive spectrometer (830 nm wavelength, 300 mW laser power and 20 s exposure time). Five spectra were collected in each fragment and submitted to Principal Components Analysis (PCA). Results showed a good correlation between the Raman spectroscopy features and the stage of hepatic fibrosis and inflammation. PCA showed that samples with higher degree of fibrosis presented higher amount of protein features (collagen), whereas samples of higher degree of inflammation presented higher features of hemoglobin, in accordance to the expected evolution of the chronic hepatitis. It has been found an important biomarker for the beginning of hepatic lesion (quinone) with a spectral feature at 1595 cm-1.

Gaggini, Marcio Cesar Reino; Navarro, Ricardo Scarparo; Stefanini, Aline Reis; Sano, Rubens Sato; Silveira, Landulfo

138

Correlation between mental health co-morbidity screening scores and clinical response in collaborative care treatment for depression.  

Science.gov (United States)

The hypothesis for this paper is that adult patients who have higher screening scores for mental health co-morbidities and depression have a greater likelihood of not responding to treatment with collaborative care management (CCM) for their depression within six months.For the 334 patients in this study, the primary endpoints were if the patient was in remission at six months (PHQ-9 score 50% of baseline score). Initial evaluation included screening for alcoholism (AUDIT), anxiety (GAD-7) and bipolar disorders (MDQ).The differences in marital status, percentage of minority patients, gender, initial PHQ-9 and AUDIT scores were not statistically significant. Mood Disorders Questionnaire (MDQ) screening was more likely to be negative for the group in remission (96.2% vs 90.0%, P=0.049) and positive for the NR group (8.0% vs 2.1%, P=0.026). GAD-7 screening was significantly lower in the remission group (9.85) than in the NR group (11.53, P=0.009).Results of multiple logistic regression analysis demonstrated that age, gender, race, marital status, PHQ-9 score and AUDIT score were not related to the odds of being NR. A one-point higher GAD-7 score was associated with approximately 6% higher adjusted odds of being NR. Patients with a positive MDQ were associated with elevated odds of non-response (adjusted OR=3.4714, P=0.044) when controlling for all other variables.A higher initial screening score for anxiety or bipolar disorder is associated with a statistically significant increase in the relative risk of patients in CCM not responding to current treatments for depression within six months. PMID:22477934

Angstman, Kurt B; Dejesus, Ramona S; Rohrer, James E

2010-09-01

139

Correlation between mental health co-morbidity screening scores and clinical response in collaborative care treatment for depression.  

UK PubMed Central (United Kingdom)

The hypothesis for this paper is that adult patients who have higher screening scores for mental health co-morbidities and depression have a greater likelihood of not responding to treatment with collaborative care management (CCM) for their depression within six months.For the 334 patients in this study, the primary endpoints were if the patient was in remission at six months (PHQ-9 score <5) or if they were non-responsive (NR) (PHQ-9 >50% of baseline score). Initial evaluation included screening for alcoholism (AUDIT), anxiety (GAD-7) and bipolar disorders (MDQ).The differences in marital status, percentage of minority patients, gender, initial PHQ-9 and AUDIT scores were not statistically significant. Mood Disorders Questionnaire (MDQ) screening was more likely to be negative for the group in remission (96.2% vs 90.0%, P=0.049) and positive for the NR group (8.0% vs 2.1%, P=0.026). GAD-7 screening was significantly lower in the remission group (9.85) than in the NR group (11.53, P=0.009).Results of multiple logistic regression analysis demonstrated that age, gender, race, marital status, PHQ-9 score and AUDIT score were not related to the odds of being NR. A one-point higher GAD-7 score was associated with approximately 6% higher adjusted odds of being NR. Patients with a positive MDQ were associated with elevated odds of non-response (adjusted OR=3.4714, P=0.044) when controlling for all other variables.A higher initial screening score for anxiety or bipolar disorder is associated with a statistically significant increase in the relative risk of patients in CCM not responding to current treatments for depression within six months.

Angstman KB; Dejesus RS; Rohrer JE

2010-09-01

140

Correlation of a single assessment numeric evaluation (SANE) rating with modified Cincinnati knee rating system and IKDC subjective total scores for patients after ACL reconstruction or knee arthroscopy.  

UK PubMed Central (United Kingdom)

BACKGROUND: Limited studies exist regarding how well a single assessment numeric evaluation (SANE) rating correlates with validated knee surveys. PURPOSE: To determine whether a SANE rating correlates positively with the International Knee Documentation Committee (IKDC) and the modified Cincinnati Knee Rating System (CKRS) total scores after knee surgery. STUDY DESIGN: Cohort study (Diagnosis); Level of evidence, 2. METHODS: Patients undergoing either anterior cruciate ligament (ACL) reconstruction or knee arthroscopy were prospectively given subjective evaluations yearly after surgery between January 2000 and June 2011. Subjective evaluations were obtained using modified CKRS and IKDC subjective knee surveys and a SANE rating. Interclass correlation coefficient was used to determine the correlation of the SANE rating to the survey total scores. Bland-Altman method was used to access precision and limits of agreement between scores. In addition, the data were analyzed according to sex and age categories (<18, 18-24, 25-40, >40 years). RESULTS: A total of 11,939 surveys were collected from 3209 patients (mean, 3.7 surveys/person; range, 1-22) after ACL reconstruction with a mean survey age of 35.2 ± 11.9 years (range, 13-72). A total of 4615 surveys were collected from 1813 patients (mean, 2.6 surveys/person; range, 1-17) after knee arthroscopy with a mean survey age of 47.4 ± 14.6 years (range, 11-88). For patients who underwent ACL reconstruction, the SANE rating had a moderate positive correlation of 0.66 to the total survey scores. For patients who underwent knee arthroscopies, the SANE rating had a strong positive correlation of 0.74 to total scores. There was minimal difference in correlations based on age group or sex. Bland-Altman analysis showed that the limits of agreement between the SANE score and the 2 surveys were met for at least 94% of patients in both patient groups. CONCLUSION: The SANE ratings exhibited moderate to strong positive correlations with the modified CKRS and IKDC subjective surveys after ACL reconstruction and knee arthroscopy for patients of all ages and both sexes.

Shelbourne KD; Barnes AF; Gray T

2012-11-01

 
 
 
 
141

Diagnostic yield of MRI for audiovestibular dysfunction using contemporary referral criteria: correlation with presenting symptoms and impact on clinical management  

Energy Technology Data Exchange (ETDEWEB)

Aim: To investigate the diagnostic yield of T2-weighted magnetic resonance imaging (MRI) screening for vestibular schwannoma and other relevant conditions in the setting of audiovestibular symptoms, given the more liberal contemporary referral criteria. To determine whether presenting clinical symptoms correlate with imaging outcome in order to guide future protocols for MRI referral. Materials and methods: Eight hundred and eighty-one consecutive MRI examinations performed in patients with audiovestibular dysfunction were reviewed. Clinical indications and findings were recorded. Case notes were reviewed in patients with positive imaging findings. Two-way, cross-tabulation, Chi-square analysis was performed to assess the relationship between presenting symptoms and imaging outcome. Results: Twelve of the 881 (1.4%) were positive for vestibular schwannoma. A further four of 881 (0.4%) revealed other relevant conditions. Incidental conditions, felt to be irrelevant to the presenting symptoms, were noted in 12 of the 881 (1.4%). In all 12 cases that were positive for vestibular schwannoma, either tinnitus or hearing loss was present. Conclusion: The yield for T2-weighted MRI to diagnose vestibular schwannoma and other relevant retrocochlear conditions was lower than for previous studies, which is likely to reflect trends in referral criteria. No single audiovestibular symptom or combination of symptoms is a statistically significant predictor of imaging outcome.

Vandervelde, C. [Department of Radiology, Guy' s and St Thomas' NHS Foundation Trust (United Kingdom)], E-mail: clivevandervelde@gmail.com; Connor, S.E.J. [Department of Radiology, Guy' s and St Thomas' NHS Foundation Trust (United Kingdom); Department of Neuroradiology, King' s College Hospital NHS Foundation Trust, London (United Kingdom)

2009-02-15

142

Diagnostic yield of MRI for audiovestibular dysfunction using contemporary referral criteria: correlation with presenting symptoms and impact on clinical management  

International Nuclear Information System (INIS)

Aim: To investigate the diagnostic yield of T2-weighted magnetic resonance imaging (MRI) screening for vestibular schwannoma and other relevant conditions in the setting of audiovestibular symptoms, given the more liberal contemporary referral criteria. To determine whether presenting clinical symptoms correlate with imaging outcome in order to guide future protocols for MRI referral. Materials and methods: Eight hundred and eighty-one consecutive MRI examinations performed in patients with audiovestibular dysfunction were reviewed. Clinical indications and findings were recorded. Case notes were reviewed in patients with positive imaging findings. Two-way, cross-tabulation, Chi-square analysis was performed to assess the relationship between presenting symptoms and imaging outcome. Results: Twelve of the 881 (1.4%) were positive for vestibular schwannoma. A further four of 881 (0.4%) revealed other relevant conditions. Incidental conditions, felt to be irrelevant to the presenting symptoms, were noted in 12 of the 881 (1.4%). In all 12 cases that were positive for vestibular schwannoma, either tinnitus or hearing loss was present. Conclusion: The yield for T2-weighted MRI to diagnose vestibular schwannoma and other relevant retrocochlear conditions was lower than for previous studies, which is likely to reflect trends in referral criteria. No single audiovestibular symptom or combination of symptoms is a statistically significant predictor of imaging outcome.

2009-01-01

143

Evaluation of the nursing workload through the nine equivalents for nursing manpower use scale and the nursing activities score: a prospective correlation study.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To determine the relationship between nursing workload measured through the nine equivalents of nursing manpower use (NEMS) scale and that measured through the nursing activities score (NAS) scale and to analyse staff needs as determined through each of the scales. METHODS: The study used a descriptive prospective correlational design to collect data between October 2007 and July 2009. Nursing workload data for 730 ICU patients were collected daily using the NAS and NEMS scales. Both scales were then correlated and used to estimate staff needs. FINDINGS: 6815 score pairs were collected, which reflected the nursing workload for each patient as calculated daily using both scales. Pearson's correlation coefficient for individual measurements obtained through the NAS and the NEMS corresponded to .672, and to .932 for the daily total workload in the unit. The staffing requirements based on the NAS scale scores were significantly higher than those based on the NEMS scale. A high correlation existed for individual measurements using both scales and for the total workload measurement in the unit. The main difference was found when analysing staffing requirements, with higher staff numbers needed for the NAS scale. CONCLUSION: Both NAS and NEMS can be used to measure the nursing workload in the ICU. Staffing requirements using NAS were higher than those using NEMS.

Carmona-Monge FJ; Rollán Rodríguez GM; Quirós Herranz C; García Gómez S; Marín-Morales D

2013-08-01

144

Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler memory scale-revised logical/verbal memory score for healthy subjects  

Energy Technology Data Exchange (ETDEWEB)

Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM). T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A P value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant. Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal, T value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal, T value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found. To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing. (orig.)

Goto, Masami [University of Tokyo Hospital, Department of Radiological Technology, Graduate School of Medicine, Tokyo (Japan); Kanazawa University, Tsunomatyou, Graduate School of Medical Science, Kanazawa (Japan); Abe, Osamu; Takao, Hidemasa; Inano, Sachiko; Mori, Harushi; Kunimatsu, Akira; Ohtomo, Kuni [University of Tokyo Hospital, Department of Radiology, Tokyo (Japan); Miyati, Tosiaki [Kanazawa University, Tsunomatyou, Graduate School of Medical Science, Kanazawa (Japan); Yoshikawa, Takeharu; Hayashi, Naoto [University of Tokyo Hospital, Department of Computational Diagnostic Radiology and Preventive Medicine, Tokyo (Japan); Kabasawa, Hiroyuki [GE Healthcare, Japan Applied Science Laboratory, Hino (Japan); Aoki, Shigeki [Juntendo University, Department of Radiology, Tokyo (Japan); Ino, Kenji; Iida, Kyouhito; Yano, Keiichi [University of Tokyo Hospital, Department of Radiological Technology, Graduate School of Medicine, Tokyo (Japan)

2011-08-15

145

Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler memory scale-revised logical/verbal memory score for healthy subjects  

International Nuclear Information System (INIS)

[en] Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM). T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A P value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant. Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal, T value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal, T value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found. To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing. (orig.)

2011-01-01

146

Correlation of volumetric mismatch and mismatch of Alberta Stroke program Early CT scores on CT perfusion maps  

International Nuclear Information System (INIS)

We aimed to determine if volumetric mismatch between tissue at risk and tissue destined to infarct on computed tomography perfusion (CTP) can be described by the mismatch of Alberta Stroke Program Early CT Score (ASPECTS). Forty patients with nonlacunar middle cerebral artery infarct 6 s and

2009-01-01

147

Alexithymic and somatisation scores in patients with temporomandibular pain disorder correlate with deficits in facial emotion recognition.  

UK PubMed Central (United Kingdom)

Current studies suggest dysfunctional emotional processing as a key factor in the aetiology of temporomandibular disorder (TMD). Investigating facial emotion recognition (FER) may offer an elegant and reliable way to study emotional processing in patients with TMD. Twenty patients with TMD and the same number of age-, sex- and education-matched controls were measured with the Facially Expressed Emotion Labelling (FEEL) test, the 26-item Toronto Alexithymia Scale (TAS-26), the Screening for Somatoform Symptoms (SOMS-2a), the German Pain Questionnaire and the 21-item Hamilton Depression Rating Scale (HAMD). The patients had significantly lower Total FEEL Scores (P = 0·021) as compared to the controls, indicating a lower accuracy of FER. Furthermore, we were able to demonstrate significant group differences with respect to the following issues: patients were more alexithymic (P = 0·006), stated more somatoform symptoms (P < 0·004) and had higher depressive scores in the HAMD (P < 0·003). The factors alexithymia and somatisation could explain 31% (adjusted 27%) of the variance of the FEEL Scores in the sample. The estimation of the standardised regression coefficients suggests an equivalent influence of TAS-26 and SOMS-2a on the FEEL Scores, whereas 'group' (patients versus healthy controls) and depressive symptoms did not contribute significantly to the model. Our findings highlight FER deficits in patients with TMD, which are partially explained by concomitant alexithymia and somatisation. As suggested previously, impaired FER in patients with TMD may further point to probable aetiological proximities between TMD and somatoform disorders.

Haas J; Eichhammer P; Traue HC; Hoffmann H; Behr M; Crönlein T; Pieh C; Busch V

2013-02-01

148

Correlation of regional distribution and morphological pattern of calcification at CT coronary artery calcium scoring with non-calcified plaque formation and stenosis  

International Nuclear Information System (INIS)

To investigate whether regional calcification patterns at CT coronary artery calcium scoring (CCS) correlate with stenosis and non-calcified plaque formation. We studied 106 patients with quantitative catheter angiography (QCA), CCS, and coronary CT angiography (cCTA). CCS was determined globally and for each artery separately. The morphological pattern of each calcification was classified as calcified nodule, shell-like, or diffuse. cCTA studies were evaluated for non-calcified plaque. The global and regional CCS and the calcification pattern were correlated with stenosis ?50% and non-calcified plaque. A total of 48/106 patients had stenosis ?50% on QCA. There was weak correlation (r = 0.36) of the global CCS with stenosis. Correlation was stronger per vessel (r = 0.55-r = 0.67). Shell-like and diffuse calcifications were significantly (p = 0.0001) more frequently associated with ?50% stenosis and non-calcified plaque (p = 0.04) than calcified nodules. As shown before, the global CCS does not correlate well with stenosis. However, regional calcium distribution and specific patterns of calcification are correlated with stenosis and non-calcified plaque. Thus, the specificity of CT calcium scoring for identifying individuals with obstructive disease could be improved by vessel-based rather than global quantification of calcium and by differentiating specific morphological patterns of calcification. (orig.)

2010-01-01

149

Correlation of regional distribution and morphological pattern of calcification at CT coronary artery calcium scoring with non-calcified plaque formation and stenosis  

Energy Technology Data Exchange (ETDEWEB)

To investigate whether regional calcification patterns at CT coronary artery calcium scoring (CCS) correlate with stenosis and non-calcified plaque formation. We studied 106 patients with quantitative catheter angiography (QCA), CCS, and coronary CT angiography (cCTA). CCS was determined globally and for each artery separately. The morphological pattern of each calcification was classified as calcified nodule, shell-like, or diffuse. cCTA studies were evaluated for non-calcified plaque. The global and regional CCS and the calcification pattern were correlated with stenosis {>=}50% and non-calcified plaque. A total of 48/106 patients had stenosis {>=}50% on QCA. There was weak correlation (r = 0.36) of the global CCS with stenosis. Correlation was stronger per vessel (r = 0.55-r = 0.67). Shell-like and diffuse calcifications were significantly (p = 0.0001) more frequently associated with {>=}50% stenosis and non-calcified plaque (p = 0.04) than calcified nodules. As shown before, the global CCS does not correlate well with stenosis. However, regional calcium distribution and specific patterns of calcification are correlated with stenosis and non-calcified plaque. Thus, the specificity of CT calcium scoring for identifying individuals with obstructive disease could be improved by vessel-based rather than global quantification of calcium and by differentiating specific morphological patterns of calcification. (orig.)

Thilo, Christian [Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States); Medical University of South Carolina, Department of Medicine, Division of Cardiology, Charleston, SC (United States); Klinikum Augsburg, Department of Cardiology, Augsburg (Germany); Gebregziabher, Mulugeta [Medical University of South Carolina, Department of Biostatistics, Bioinformatics and Epidemiology, Charleston, SC (United States); Mayer, Florian B.; Costello, Philip [Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States); Zwerner, Peter L.; Schoepf, U.J. [Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States); Medical University of South Carolina, Department of Medicine, Division of Cardiology, Charleston, SC (United States)

2010-04-15

150

Estimativas de herdabilidade e correlações para escores visuais, peso e altura ao sobreano em rebanhos da raça Nelore/ Estimates of heritabilities and correlations for visual scores, weight and height at 550 days of age in Nelore cattle herds  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Os objetivos neste trabalho foram avaliar as relações entre os escores visuais de estrutura corporal, precocidade e musculosidade ao sobreano (aproximadamente 550 dias de idade) com características de crescimento para verificar as possibilidades de utilizar essas características como critérios de seleção. Foram obtidas estimativas dos componentes de covariâncias por máxima verossimilhança restrita empregando-se um modelo animal com o efeito fixo de grupo contemp (more) orâneo e a idade como covariável (efeitos linear e quadrático). Os grupos contemporâneos foram definidos pelas variáveis: sexo; ano, estação e fazenda de nascimento; e fazenda e grupo de manejo aos 120, 210, 365 e 550 dias de idade. Foram utilizadas 1.367 observações de estrutura corporal, precocidade e musculosidade. As estimativas de herdabilidade foram de 0,24 ± 0,09 para estrutura corporal; 0,63 ± 0,12 para precocidade e 0,48 ± 0,11 para musculosidade, e as estimativas de correlações genéticas entre os escores foram 0,49 entre estrutura corporal e precocidade; 0,63 entre estrutura corporal e musculosidade; e 0,90 entre precocidade e musculosidade. As correlações genéticas entre os escores de estrutura corporal, precocidade e musculosidade, e o peso ao sobreano foram todas positivas (0,83; 0,42 e 0,50, respectivamente), enquanto as estimativas de correlações genéticas entre altura de posterior e os escores de estrutura corporal, precocidade e musculosidade, respectivamente, foram 0,57, -0,29 e -0,33. As características estrutura corporal, precocidade e musculosidade ao sobreano apresentaram variação genética aditiva de moderada a alta. As correlações genéticas dos escores com altura do posterior indicam que a seleção de animais mais altos, ainda que indireta, pode ocasionar aumento da estrutura corporal média dos animais, que poderão ser menos precoces e menos musculosos ao sobreano. A seleção para os escores visuais, principalmente para estrutura corporal, deve promover aumento no peso ao sobreano dos animais. Abstract in english The objectives of this study were to evaluate the associations between visual scores of body structure, precocity and muscling at 550 days of age and growing traits, and verify the possibilities of applying these traits as selection criteria. (Co)variance components were estimated by restricted maximum likelihood, employing an animal model with fixed effects of contemporary group and age as a covariate (linear and quadratic effects). Contemporary groups were defined by va (more) riables: sex; year, season and herd of birth; herd and management group at 120, 210, 365 and 550 days of age. Scores from 1,367 animals for body structure, precocity and muscling were evaluated. Heritability estimates for the visual scores were 0.24 ± 0.09 for body structure, 0.63 ± 0.12 for precocity and 0.48 ± 0.11 for muscling. Genetic correlations estimates among the scores were 0.49 for body structure and precocity, 0.63 between body structure and muscling, 0.90 between precocity and muscling. The genetic correlation estimates among the scores of body structure, precocity and muscling and weight at 550 days were all positive (0.83, 0.42 and 0.50, respectively), while the genetic correlation estimates between hip height and body structure, precocity and muscling were 0,57, -0,29 and -0,33, respectively. Scores for body structure, precocity and muscling at 550 days of age presented moderate-to-large additive genetic variability. The genetic correlation estimates between visual scores and hip height indicated that the selection of taller animals, even though indirectly, can increase the body structure of animals and decrease precocity and muscling at 550 days. Selection for visual scores, especially body structure, should increase animal weight at 550 days.

Koury Filho, William; Albuquerque, Lucia Galvão de; Alencar, Maurício Mello de; Forni, Selma; Silva, Josineudson Augusto II de Vasconcelos; Lôbo, Raysildo Barbosa

2009-12-01

151

Estimativas de herdabilidade e correlações para escores visuais, peso e altura ao sobreano em rebanhos da raça Nelore Estimates of heritabilities and correlations for visual scores, weight and height at 550 days of age in Nelore cattle herds  

Directory of Open Access Journals (Sweden)

Full Text Available Os objetivos neste trabalho foram avaliar as relações entre os escores visuais de estrutura corporal, precocidade e musculosidade ao sobreano (aproximadamente 550 dias de idade) com características de crescimento para verificar as possibilidades de utilizar essas características como critérios de seleção. Foram obtidas estimativas dos componentes de covariâncias por máxima verossimilhança restrita empregando-se um modelo animal com o efeito fixo de grupo contemporâneo e a idade como covariável (efeitos linear e quadrático). Os grupos contemporâneos foram definidos pelas variáveis: sexo; ano, estação e fazenda de nascimento; e fazenda e grupo de manejo aos 120, 210, 365 e 550 dias de idade. Foram utilizadas 1.367 observações de estrutura corporal, precocidade e musculosidade. As estimativas de herdabilidade foram de 0,24 ± 0,09 para estrutura corporal; 0,63 ± 0,12 para precocidade e 0,48 ± 0,11 para musculosidade, e as estimativas de correlações genéticas entre os escores foram 0,49 entre estrutura corporal e precocidade; 0,63 entre estrutura corporal e musculosidade; e 0,90 entre precocidade e musculosidade. As correlações genéticas entre os escores de estrutura corporal, precocidade e musculosidade, e o peso ao sobreano foram todas positivas (0,83; 0,42 e 0,50, respectivamente), enquanto as estimativas de correlações genéticas entre altura de posterior e os escores de estrutura corporal, precocidade e musculosidade, respectivamente, foram 0,57, -0,29 e -0,33. As características estrutura corporal, precocidade e musculosidade ao sobreano apresentaram variação genética aditiva de moderada a alta. As correlações genéticas dos escores com altura do posterior indicam que a seleção de animais mais altos, ainda que indireta, pode ocasionar aumento da estrutura corporal média dos animais, que poderão ser menos precoces e menos musculosos ao sobreano. A seleção para os escores visuais, principalmente para estrutura corporal, deve promover aumento no peso ao sobreano dos animais.The objectives of this study were to evaluate the associations between visual scores of body structure, precocity and muscling at 550 days of age and growing traits, and verify the possibilities of applying these traits as selection criteria. (Co)variance components were estimated by restricted maximum likelihood, employing an animal model with fixed effects of contemporary group and age as a covariate (linear and quadratic effects). Contemporary groups were defined by variables: sex; year, season and herd of birth; herd and management group at 120, 210, 365 and 550 days of age. Scores from 1,367 animals for body structure, precocity and muscling were evaluated. Heritability estimates for the visual scores were 0.24 ± 0.09 for body structure, 0.63 ± 0.12 for precocity and 0.48 ± 0.11 for muscling. Genetic correlations estimates among the scores were 0.49 for body structure and precocity, 0.63 between body structure and muscling, 0.90 between precocity and muscling. The genetic correlation estimates among the scores of body structure, precocity and muscling and weight at 550 days were all positive (0.83, 0.42 and 0.50, respectively), while the genetic correlation estimates between hip height and body structure, precocity and muscling were 0,57, -0,29 and -0,33, respectively. Scores for body structure, precocity and muscling at 550 days of age presented moderate-to-large additive genetic variability. The genetic correlation estimates between visual scores and hip height indicated that the selection of taller animals, even though indirectly, can increase the body structure of animals and decrease precocity and muscling at 550 days. Selection for visual scores, especially body structure, should increase animal weight at 550 days.

William Koury Filho; Lucia Galvão de Albuquerque; Maurício Mello de Alencar; Selma Forni; Josineudson Augusto II de Vasconcelos Silva; Raysildo Barbosa Lôbo

2009-01-01

152

Criteria of GenCall score to edit marker data and methods to handle missing markers have an influence on accuracy of genomic predictions  

DEFF Research Database (Denmark)

The aim of this study was to investigate the effect of different strategies for handling low-quality or missing data on prediction accuracy for direct genomic values of protein yield, mastitis and fertility using a Bayesian variable model and a GBLUP model in the Danish Jersey population. The data contained 1071 Jersey bulls that were genotyped with the Illumina Bovine 50K chip. After preliminary editing, 39227 SNP remained in the dataset. Four methods to handle missing genotypes were: 1) BEAGLE: missing markers were imputed using Beagle 3.3 software, 2) COMMON: missing genotypes at a locus were replaced by the most common genotype at this locus observed in the marker data, 3) EX-ALLELE: missing marker genotypes at a locus were treated as an extra allele, and 4) POP-EXP: missing genotypes at a locus were replaced with population expectation at this locus. It was shown that among the methods used in this study, imputation with Beagle was the best approach to handle missing genotypes. Treating missing markers as a pseudo-allele, replacing missing markers with a population average or substituting the most common alleles each reduced the accuracy of genomic predictions. The results from this study suggest that missing genotypes should be imputed in order to improve genomic prediction. Editing the marker data with stringent threshold on GenCall (GC) scores and then imputing the discarded genotypes did not lead to higher accuracy. All marker genotypes with a GC score over 0.15 should be retained for genomic prediction

Edriss, Vahid; Guldbrandtsen, Bernt

2013-01-01

153

Preoperative 18F-FDG uptake is strongly correlated with malignancy, Weiss score, and molecular markers of aggressiveness in adrenal cortical tumors.  

UK PubMed Central (United Kingdom)

BACKGROUND: Adrenal incidentaloma are frequent in the general population. It can be difficult to diagnose adrenocortical carcinomas among them, even with the progress of imaging techniques. We studied the results of PET-FDG in the diagnosis of such tumours. METHODS: We studied patients referred to the Department of Endocrine Surgery at La Timone Hospital, Marseilles, France, between June 2006 and October 2010 for adrenal tumours. All patients underwent a complete work-up (biological tests and imagery), completed with PET-FDG. We compared the results of PET-FDG and molecular analysis with Weiss score and clinical follow-up. We calculated correlations with the Pearson test. RESULTS: A total of 51 patients were studied. We found that PET-FDG had a sensitivity of 95% and specificity of 97% for the diagnosis of adrenocortical carcinoma. The correlation between PET-FDG and Weiss score was 77% (P ? 0.0001). Molecular analyses were correlated as well with Weiss score and malignancy (P < 0.05). CONCLUSIONS: The nature of atypical adrenal masses can be difficult to define during preoperative investigations. For undetermined tumours smaller than 6 cm, characterization with PET-FDG can be one more diagnostic argument pointing to malignancy. It could potentially change the therapeutic strategy and surgical management. In our experience, molecular analyses are available after surgery and have less impact on the therapeutic strategy than PET-FDG. Preoperative PET-FDG can be an asset in the management of adrenal incidentaloma and adrenocortical carcinoma.

Gust L; Taieb D; Beliard A; Barlier A; Morange I; de Micco C; Henry JF; Sebag F

2012-06-01

154

CYP3A activity in severe liver cirrhosis correlates with Child-Pugh and Model for End-Stage Liver Disease (MELD) scores.  

UK PubMed Central (United Kingdom)

AIM(S): Impaired liver function often necessitates drug dose adjustment to avoid excessive drug accumulation and adverse events, but a marker for the extent of the required adjustment is lacking. The aim of this study was to investigate whether Child-Pugh (CP) and model for end-stage liver disease (MELD) scores correlate with drug clearance. METHODS: Midazolam was used as a CYP3A probe and its pharmacokinetics was analysed in 24 patients with mild to severe liver cirrhosis (n = 4, 10, and 10 with CP class A, B, and C, respectively) and 6 patients without liver disease. RESULTS: Both scores correlated well with unbound midazolam clearance (CLu ), unbound midazolam fraction, and half-life (all P?correlation with unbound midazolam clearance suggests that either score predicts the metabolic capacity of CYP3A, the most relevant drug metabolising enzyme subfamily in humans.

Albarmawi A; Czock D; Gauss A; Ehehalt R; Bermejo JL; Burhenne J; Ganten TM; Sauer P; Haefeli WE

2013-06-01

155

Segmented corpus callosum diffusivity correlates with the Expanded Disability Status Scale score in the early stages of relapsing-remitting multiple sclerosis.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The aim of this study was to characterize the microscopic damage to the corpus callosum in relapsing-remitting multiple sclerosis (RRMS) with diffusion tensor imaging and to investigate the correlation of this damage with disability. The diffusion tensor imaging parameters of fractional anisotropy and mean diffusivity provide information about the integrity of cell membranes, offering two more specific indices, namely the axial and radial diffusivities, which are useful for discriminating axon loss from demyelination. METHOD: Brain magnetic resonance imaging exams of 30 relapsing-remitting multiple sclerosis patients and 30 age- and sex-matched healthy controls were acquired in a 3T scanner. The axial diffusivities, radial diffusivities, fractional anisotropy, and mean diffusivity of five segments of the corpus callosum, correlated to the Expanded Disability Status Scale score, were obtained. RESULTS: All corpus callosum segments showed increased radial diffusivities and mean diffusivity, as well as decreased fractional anisotropy, in the relapsing-remitting multiple sclerosis group. The axial diffusivity was increased in the posterior midbody and splenium. The Expanded Disability Status Scale scores correlated more strongly with axial diffusivities and mean diffusivity, with an isolated correlation with radial diffusivities in the posterior midbody of the corpus callosum. There was no significant correlation with lesion loads. CONCLUSION: Neurological dysfunction in relapsing-remitting multiple sclerosis can be influenced by commissural disconnection, and the diffusion indices of diffusion tensor imaging are potential biomarkers of disability that can be assessed during follow-up.

Rimkus Cde M; Junqueira Tde F; Callegaro D; Otaduy MC; Leite Cda C

2013-01-01

156

Segmented corpus callosum diffusivity correlates with the Expanded Disability Status Scale score in the early stages of relapsing-remitting multiple sclerosis  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english OBJECTIVE: The aim of this study was to characterize the microscopic damage to the corpus callosum in relapsing-remitting multiple sclerosis (RRMS) with diffusion tensor imaging and to investigate the correlation of this damage with disability. The diffusion tensor imaging parameters of fractional anisotropy and mean diffusivity provide information about the integrity of cell membranes, offering two more specific indices, namely the axial and radial diffusivities, which (more) are useful for discriminating axon loss from demyelination. METHOD: Brain magnetic resonance imaging exams of 30 relapsing-remitting multiple sclerosis patients and 30 age- and sex-matched healthy controls were acquired in a 3T scanner. The axial diffusivities, radial diffusivities, fractional anisotropy, and mean diffusivity of five segments of the corpus callosum, correlated to the Expanded Disability Status Scale score, were obtained. RESULTS: All corpus callosum segments showed increased radial diffusivities and mean diffusivity, as well as decreased fractional anisotropy, in the relapsing-remitting multiple sclerosis group. The axial diffusivity was increased in the posterior midbody and splenium. The Expanded Disability Status Scale scores correlated more strongly with axial diffusivities and mean diffusivity, with an isolated correlation with radial diffusivities in the posterior midbody of the corpus callosum. There was no significant correlation with lesion loads. CONCLUSION: Neurological dysfunction in relapsing-remitting multiple sclerosis can be influenced by commissural disconnection, and the diffusion indices of diffusion tensor imaging are potential biomarkers of disability that can be assessed during follow-up.

Rimkus, Carolina de Medeiros; Junqueira, Thiago de Faria; Callegaro, Dagoberto; Otaduy, Maria Concepcion Garcia; Leite, Claudia da Costa

2013-01-01

157

Empirical correlates of low scores on MMPI-2/MMPI-2-RF restructured clinical scales in a sample of university students.  

UK PubMed Central (United Kingdom)

In the present study, the authors explored the meaning of low scores on the MMPI-2/MMPI-2-RF restructured clinical (RC) scales. Using responses of a sample of university students (N = 811), the authors examined whether low (T < 39), within-normal-limits (T = 39-64), and high (T > 65) score levels on the RC scales are differentially associated with multidimensional personality questionnaire (MPQ)-defined personality descriptions. Eleven primary MPQ scales and three higher order MPQ scales (negative emotionality, positive emotionality, and constraint) were used to yield these descriptions. MANOVAs were conducted for each RC scale and followed up by univariate ANOVAs and post hoc Dunnett T3 tests to identify reliable RC-scale-defined group differences for the individual MPQ scales. For those cases that exhibited significant differences between the low and within-normal subgroups on the Dunnett T3 tests, effect sizes were computed. The authors identified and discussed meaningful MPQ-based personality characteristics of the low scoring subjects.

Avdeyeva TV; Tellegen A; Ben-Porath YS

2012-09-01

158

Performance of an Automated Polysomnography Scoring System Versus Computer-Assisted Manual Scoring  

Science.gov (United States)

Study Objectives: Manual scoring of polysomnograms (PSG) is labor intensive and has considerable variance between scorers. Automation of scoring could reduce cost and improve reproducibility. The purpose of this study was to compare a new automated scoring system (YST-Limited, Winnipeg, Canada) with computer-assisted manual scoring. Design: Technical assessment. Setting: Five academic medical centers. Participants: N/A. Interventions: N/A. Measurements and Results: Seventy PSG files were selected at University of Pennsylvania (Penn) and distributed to five US academic sleep centers. Two blinded technologists from each center scored each file. Automatic scoring was performed at Penn by a YST Limited technician using a laptop containing the software. Variables examined were sleep stages, arousals, and apnea-hypopnea index (AHI) using three methods of identifying hypopneas. Automatic scores were not edited and were compared to the average scores of the 10 technologists. Intraclass correlation coefficient (ICC) was obtained for the 70 pairs and compared to across-sites ICCs for manually scored results. ICCs for automatic versus manual scoring were > 0.8 for total sleep time, stage N2, and nonrapid eye movement arousals and > 0.9 for AHI scored by primary and secondary American Academy of Sleep Medicine criteria. ICCs for other variables were not as high but were comparable to the across-site ICCs for manually scored results. Conclusion: The automatic system yielded results that were similar to those obtained by experienced technologists. Very good ICCs were obtained for many primary PSG outcome measures. This automated scoring software, particularly if supplemented with manual editing, may increase laboratory efficiency and standardize PSG scoring results within and across sleep centers. Citation: Malhotra A; Younes M; Kuna ST; Benca R; Kushida CA; Walsh J; Hanlon A; Staley B; Pack AI; Pien GW. Performance of an automated polysomnography scoring system versus computer-assisted manual scoring. SLEEP 2013;36(4):573-582.

Malhotra, Atul; Younes, Magdy; Kuna, Samuel T.; Benca, Ruth; Kushida, Clete A.; Walsh, James; Hanlon, Alexandra; Staley, Bethany; Pack, Allan I.; Pien, Grace W.

2013-01-01

159

Changes in Allergy Symptoms and Depression Scores Are Positively Correlated In Patients With Recurrent Mood Disorders Exposed to Seasonal Peaks in Aeroallergens  

Science.gov (United States)

Although growing evidence supports an association between allergy, allergens and depression, it remains unknown if this relationship is between “states” (possible triggers) or “traits” (possible vulnerabilities). We hypothesized that patients with recurrent mood disorders who are sensitized to tree pollen (as determined by allergen specific IgE antibodies), in comparison to those who are not sensitized, would report larger negative changes in mood during exposure to tree pollen in spring. We also hypothesized that differences between high and low tree pollen periods in self reported allergy symptoms would correlate positively with differences in self reported depression scores. We present 1-year preliminary data on the first 51 patients with unipolar or bipolar disorder (age: 19-63 years, 65% female, twelve patients were tree-pollen IgE positive). Ratings of mood and allergic disease status were performed once during the peak airborne pollen counts and once during the period of low airborne pollen counts, as reported by two local pollen counting stations. Linear regression models were developed to examine associations of changes in depression scores (dependent variable) with tree pollen sensitization, changes in the allergy symptom severity score, adjusted for gender and order of testing. We did not confirm the hypothesized relationship between a specific tree pollen sensitization and changes in mood during tree pollen exposure. We did confirm the hypothesized positive relationship between the changes in allergy symptoms and changes in subjects' depression scores (adjusted p<0.05). This result is consistent with previous epidemiological evidence connecting allergy with depression, as well as our recent reports of increased expression of cytokines in the prefrontal cortex in victims of suicide and in experimental animals sensitized and exposed to tree pollen. A relationship between changes in allergy symptom scores and changes in depression scores supports a state-level rather than only trait-level relationship, and thus lends optimism to future causality-testing interventional studies, which might then lead to novel preventative environmental interventions in mood disorders.

Postolache, Teodor T.; Lapidus, Manana; Sander, Evan R.; Langenberg, Patricia; Hamilton, Robert G.; Soriano, Joseph J.; McDonald, Jessica S.; Furst, Nancy; Bai, Jie; Scrandis, Debra A.; Cabassa, Johanna A.; Stiller, John W.; Balis, Theodora; Guzman, Alvaro; Togias, Alkis; Tonelli, Leonardo H.

2007-01-01

160

The interferon-regulated gene signature is elevated in subacute cutaneous lupus erythematosus and discoid lupus erythematosus and correlates with the cutaneous lupus area and severity index score.  

UK PubMed Central (United Kingdom)

BACKGROUND: There is increased expression of type I interferon (IFN)-regulated proteins in the blood and target tissues of patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). Patients with SLE have increased IFN-regulated gene expression pointing towards a possible underlying genetic defect. OBJECTIVES: To determine expression levels of five type I IFN-regulated genes that are highly expressed in SLE in the peripheral blood of patients with CLE and to correlate the expression levels with cutaneous disease activity. METHODS: Peripheral blood was obtained from 10 healthy controls and 30 patients with CLE, including eight with concomitant SLE. Total RNA was extracted and reverse transcribed into complementary DNA. Gene expression levels were measured by real-time polymerase chain reaction. Gene expression was normalized to GAPDH, standardized to healthy controls and then summed to calculate an IFN score for each patient. Disease activity was assessed with the Cutaneous Lupus Area and Severity Index (CLASI). RESULTS: Patients with subacute CLE (SCLE) and discoid lupus erythematosus (DLE) had elevated IFN scores compared with healthy controls regardless of concomitant SLE (P < 0·01 with SLE and P < 0·05 without SLE). There was no difference between patients with tumid lupus erythematosus (TLE) and healthy controls. The IFN score correlated with CLASI scores (Spearman's rho = 0·55, P = 0·0017). CONCLUSIONS: Patients with SCLE and DLE have an IFN signature, as seen in SLE. The level of gene expression correlates with cutaneous disease activity. These findings support a shared pathogenesis between SLE and some subtypes of CLE.

Braunstein I; Klein R; Okawa J; Werth VP

2012-05-01

 
 
 
 
161

Correlações genéticas entre escores visuais e características reprodutivas em bovinos Nelore usando inferência bayesiana/ Genetic correlations between visual scores and reproductive traits in Nelore cattle using Bayesian inference  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O objetivo deste trabalho foi estimar a herdabilidade e as correlações genéticas entre escores visuais e características reprodutivas de animais da raça Nelore. As características avaliadas foram: precocidade, musculatura, e escores de conformação à desmama (PD, MD e CD, respectivamente) e ao sobreano (PS, MS e CS, respectivamente); idade ao primeiro parto (IPP); e perímetro escrotal (PE). Foram utilizadas informações de 66.244 animais, nascidos entre 1990 e 2 (more) 006. Os parâmetros genéticos foram estimados em análises bicaracterísticas, com inferência bayesiana. Foi utilizado um modelo linear para IPP e PE, e um modelo não linear ("threshold") para os escores visuais. As herdabilidades estimadas foram: CD, 0,19±0,02; PD, 0,23±0,02; MD, 0,20±0,02; CS, 0,26±0,01; PS, 0,33±0,02; MS, 0,32±0,02; IPP, 0,16±0,03; e PE, 0,36±0,02. As correlações genéticas estimadas entre os escores visuais e IPP foram negativas, de -0,18±0,03 a -0,29±0,02. Correlações genéticas positivas foram obtidas entre os escores visuais e o PE, de 0,19±0,01 a 0,31±0,01. A seleção de animais com os maiores escores visuais, principalmente ao sobreano, permite melhorar o desempenho reprodutivo dos rebanhos Abstract in english The aim of this work was to estimate the heritability and the genetic correlations between visual scores and reproductive traits of Nelore cattle. The traits evaluated were: finishing, muscling, and conformation scores at weaning (PD, MD, and CD, respectively) and yearling (PS, MS and CS, respectively); age at the first calving (IPP) and scrotal circumference (PE). The records of 66,244 animals born between 1990 and 2006 were used. The genetic parameters were estimated us (more) ing bi-trait animal analyses with Bayesian inference. A linear model for IPP and PE and a nonlinear (threshold) model for visual scores were used. The heritability estimates were: CD, 0.19±0.02; PD, 0.23±0.02; MD, 0.20±0.02; CS, 0.26±0.01; PS, 0.33±0.02; MS, 0.32±0.02; IPP, 0.16±0.03; and PE, 0.36±0.02. Genetic correlation estimates between visual scores and IPP were negative, varying from -0.18±0.03 to -0.29±0.02. Positive genetic correlations were obtained between the visual scores and PE, from 0.19±0.01 to 0.31±0.01. Animal selection with the highest visual scores, mainly those taken after the yearling age, allows to improve herd reproductive traits

Boligon, Arione Augusti; Albuquerque, Lucia Galvão de

2010-12-01

162

Bone mineral density (BMD) composite index scores developed from bone densitometry (DXA and QCT) simplifies correlative and predictive analyses in adolescent's bone health  

International Nuclear Information System (INIS)

Full text: Introduction and aim. Adolescence is a critical period to accumulate 50-70% of adult's bone mass. Hence, precise bone mass determination is important to monitor BMD development among adolescents in health and disease. It is uncertain at which skeletal site BMD is best predicted by bone-mass determinants. Besides, BMD measured at different sites of an individual can be condensed into a composite-index-score to simplify correlation, outcome prediction and data interpretation. This study describes the development of BMD composite index scores (BMD-CISs) to correlate with bone growth determinants in adolescents. Subjects and methods BMD measurements using DXA: Norland-XR36 (spine, femoral-neck, trochanter and Ward's triangle) and pQCT: Denisiscan-2000 (distal-radius and tibia) were obtained from 101 healthy girls aged 12-15 years to develop the BMD-CISs. Adolescent bone growth predictors (weight, height, pubertal-status, weight-bearing physical-exercise and bone-turnover markers) were evaluated to correlate with BMD-CISs. Factor and principle-component analyses were used to examine the internal structure of 11 BMD skeletal sites and variables, and to create new BMD-CISs which summarize the characteristics of parent BMD-variables. Correlations between the BMD-CISs and parent BMD variables were performed. Univariate and multivariate analysis were performed to associate BMD-CISs with bone growth predictors for examining the strength of correlations and predictions when compared with the original BMD variables. Results. Two independent DXA-generated BMD-CIS and pQCT-generated BMD-CIS were obtained to summarize the 11 original BMD variables. Each BMD-CIS correlated highly with respective DXA or pQCT variable (r=0.32-0.92; P

2006-01-01

163

Alexithymic and somatisation scores in patients with temporomandibular pain disorder correlate with deficits in facial emotion recognition.  

Science.gov (United States)

Current studies suggest dysfunctional emotional processing as a key factor in the aetiology of temporomandibular disorder (TMD). Investigating facial emotion recognition (FER) may offer an elegant and reliable way to study emotional processing in patients with TMD. Twenty patients with TMD and the same number of age-, sex- and education-matched controls were measured with the Facially Expressed Emotion Labelling (FEEL) test, the 26-item Toronto Alexithymia Scale (TAS-26), the Screening for Somatoform Symptoms (SOMS-2a), the German Pain Questionnaire and the 21-item Hamilton Depression Rating Scale (HAMD). The patients had significantly lower Total FEEL Scores (P = 0·021) as compared to the controls, indicating a lower accuracy of FER. Furthermore, we were able to demonstrate significant group differences with respect to the following issues: patients were more alexithymic (P = 0·006), stated more somatoform symptoms (P FER deficits in patients with TMD, which are partially explained by concomitant alexithymia and somatisation. As suggested previously, impaired FER in patients with TMD may further point to probable aetiological proximities between TMD and somatoform disorders. PMID:23137311

Haas, J; Eichhammer, P; Traue, H C; Hoffmann, H; Behr, M; Crönlein, T; Pieh, C; Busch, V

2012-11-09

164

New electrocardiographic criteria for the differentiation between counterclockwise and clockwise atrial flutter: correlation with electrophysiological study and radiofrequency catheter ablation  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objective—To develop new electrocardiographic (ECG) criteria for the differentiation between counterclockwise and clockwise atrial flutters.?Background—Traditionally, the ECG differentiation between counterclockwise and clockwise atrial flutters is based on the flutter wave polarity in the inferior ...

Lai, L; Lin, J; Lin, L; Chen, W; Ho, Y; Tseng, Y; Chen, C; Lee, Y; Lien, W; Huang, S

165

Relationships between cardiac magnetic resonance imaging abnormalities in the inter-ventricular septum and Selvester QRS scoring criteria for anterior-septal myocardial infarction in patients with right ventricular volume overload.  

UK PubMed Central (United Kingdom)

BACKGROUND: Patients with ostium secundum atrial septal defects (ASDs) were studied to determine the prevalence of Selvester anteroseptal myocardial infarction QRS points, and to test the hypothesis that there is a relationship between these criteria and thinning and/or scarring of the inter-ventricular septum (IVS). METHODS: Demographic, electrocardiographic (ECG), and cardiac magnetic resonance imaging (CMR) data were acquired on 46 patients with a secundum ASD closed percutaneously. Selvester QRS scoring on patient ECGs was performed for areas representing the anteroseptal region of the left ventricle (LV). The IVS to LV free wall thickness ratio was used to assess thinning of the IVS while late gadolinium enhancement (LGE) of the IVS was used for scarring; both using CMR. RESULTS: Twenty-four (52%) patients scored Selvester QRS points in the anteroseptal region with a mean score of 2.6±1.8. The mean IVS/LV free wall thickness ratio at the basal level and mid-ventricular level was 1.1±0.3 and 1.3±0.3, respectively. There was no association of Selvester QRS points with IVS/LV free wall ratio at the basal (p=0.59) or mid-ventricular (p=0.13) levels. The one patient with LGE in the IVS had 4 Selvester anteroseptal QRS points. CONCLUSION: The results of our study demonstrate that in our patient population there is a 52% prevalence of Selvester anteroseptal QRS points which are due to thinning and/or scarring of the IVS in only one patient.

Siddiqui AM; Samad Z; Crowley AL; Hakacova N; Harrison JK; Wagner GS

2013-05-01

166

Meniscal and articular cartilage lesions in the anterior cruciate ligament-deficient knee: correlation between time from injury and knee scores.  

UK PubMed Central (United Kingdom)

PURPOSE: Anterior cruciate ligament (ACL) rupture is associated with meniscal tears and/or articular cartilage damage. The aim of this study was twofold: (a) to report and correlate the incidence of meniscal and cartilage lesions in ACL-deficient knees with time from injury and (b) to correlate lesions of menisci and cartilage with widely used knee scores. METHODS: Data were analysed from 109 consecutive patients with ACL rupture. Meniscal and articular cartilage lesions were documented during the arthroscopic reconstruction of the ACL. Patients were distributed into 3 groups according to time from injury; group A: 0-3 months (35 patients), group B: 3-12 months (39 patients) and group C: more than 12 months (35 patients). Lysholm, KOOS and IKDC rating scales were recorded preoperatively. Logistic regression analyses were applied to correlate the concomitant intra-articular pathologies with the time from injury and knee-rating scales. RESULTS: Of 109 patients, 32 (29 %) had a medial meniscus tear, 20 (19 %) had a lateral meniscus tear, 17 (15 %) had both menisci torn and 40 (37 %) had no meniscal tear. Analysis revealed that time from injury was not a significant factor for the presence of a meniscal lesion. The odds of development of a high-grade cartilage lesion in an ACL-deficient knee reconstructed more than 12 months from time from injury are 5.5 and 12.5 times higher when compared with knees that underwent ACL reconstruction less than 3 months and between 3 and 12 months after knee injury, respectively. No association was found between intra-articular pathology and the KOOS and Lysholm scores. A positive correlation between the IKDC score and patients without any intra-articular pathology was found. CONCLUSIONS: The presence of high-grade cartilage lesions is significantly increased in an ACL-deficient knee when reconstruction is performed more than 12 months after injury. However, the incidence of meniscal tears is not increased significantly. Correlation of intra-articular pathology in ACL-deficient knees with knee-rating scales is weak. LEVEL OF EVIDENCE: Diagnostic study, Level II.

Michalitsis S; Vlychou M; Malizos KN; Thriskos P; Hantes ME

2013-04-01

167

Meniscal and articular cartilage lesions in the anterior cruciate ligament-deficient knee: correlation between time from injury and knee scores.  

Science.gov (United States)

PURPOSE: Anterior cruciate ligament (ACL) rupture is associated with meniscal tears and/or articular cartilage damage. The aim of this study was twofold: (a) to report and correlate the incidence of meniscal and cartilage lesions in ACL-deficient knees with time from injury and (b) to correlate lesions of menisci and cartilage with widely used knee scores. METHODS: Data were analysed from 109 consecutive patients with ACL rupture. Meniscal and articular cartilage lesions were documented during the arthroscopic reconstruction of the ACL. Patients were distributed into 3 groups according to time from injury; group A: 0-3 months (35 patients), group B: 3-12 months (39 patients) and group C: more than 12 months (35 patients). Lysholm, KOOS and IKDC rating scales were recorded preoperatively. Logistic regression analyses were applied to correlate the concomitant intra-articular pathologies with the time from injury and knee-rating scales. RESULTS: Of 109 patients, 32 (29 %) had a medial meniscus tear, 20 (19 %) had a lateral meniscus tear, 17 (15 %) had both menisci torn and 40 (37 %) had no meniscal tear. Analysis revealed that time from injury was not a significant factor for the presence of a meniscal lesion. The odds of development of a high-grade cartilage lesion in an ACL-deficient knee reconstructed more than 12 months from time from injury are 5.5 and 12.5 times higher when compared with knees that underwent ACL reconstruction less than 3 months and between 3 and 12 months after knee injury, respectively. No association was found between intra-articular pathology and the KOOS and Lysholm scores. A positive correlation between the IKDC score and patients without any intra-articular pathology was found. CONCLUSIONS: The presence of high-grade cartilage lesions is significantly increased in an ACL-deficient knee when reconstruction is performed more than 12 months after injury. However, the incidence of meniscal tears is not increased significantly. Correlation of intra-articular pathology in ACL-deficient knees with knee-rating scales is weak. LEVEL OF EVIDENCE: Diagnostic study, Level II. PMID:23595538

Michalitsis, Sotirios; Vlychou, Mariana; Malizos, Konstantinos N; Thriskos, Paschal; Hantes, Michael E

2013-04-18

168

Bi-exponential T2* analysis of healthy and diseased Achilles tendons: an in vivo preliminary magnetic resonance study and correlation with clinical score.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To compare mono- and bi-exponential T2* analysis in healthy and degenerated Achilles tendons using a recently introduced magnetic resonance variable-echo-time sequence (vTE) for T2* mapping. METHODS: Ten volunteers and ten patients were included in the study. A variable-echo-time sequence was used with 20 echo times. Images were post-processed with both techniques, mono- and bi-exponential [T2*m, short T2* component (T2*s) and long T2* component (T2*l)]. The number of mono- and bi-exponentially decaying pixels in each region of interest was expressed as a ratio (B/M). Patients were clinically assessed with the Achilles Tendon Rupture Score (ATRS), and these values were correlated with the T2* values. RESULTS: The means for both T2*m and T2*s were statistically significantly different between patients and volunteers; however, for T2*s, the P value was lower. In patients, the Pearson correlation coefficient between ATRS and T2*s was -0.816 (P?=?0.007). CONCLUSION: The proposed variable-echo-time sequence can be successfully used as an alternative method to UTE sequences with some added benefits, such as a short imaging time along with relatively high resolution and minimised blurring artefacts, and minimised susceptibility artefacts and chemical shift artefacts. Bi-exponential T2* calculation is superior to mono-exponential in terms of statistical significance for the diagnosis of Achilles tendinopathy. KEY POINTS: • Magnetic resonance imaging offers new insight into healthy and diseased Achilles tendons • Bi-exponential T2* calculation in Achilles tendons is more beneficial than mono-exponential • A short T2* component correlates strongly with clinical score • Variable echo time sequences successfully used instead of ultrashort echo time sequences.

Juras V; Apprich S; Szomolanyi P; Bieri O; Deligianni X; Trattnig S

2013-06-01

169

Criteria correlation used to thermal oldness evaluation of the electrical equipment; Correlacao dos criterios utilizados para avaliacao do envelhecimento termico de equipamentos eletricos  

Energy Technology Data Exchange (ETDEWEB)

The interrelation between the parameters used to establish criteria to evaluate the electrical equipment oldness, are presented. Accelerated oldness assays made in laboratory on paper/oil insulation system, to establish a correlation between the paper polymerization and its mechanical properties, through the calculation of the polymerization degree, are discussed. According to the author, the better evaluation criterion is the absolute value of the paper polymerization degree 5 refs., 5 figs., 1 tab.

D`Almeida e Silva, V.L. [CEPEL, Rio de Janeiro, RJ (Brazil); Vieira, C.L.S. [Tecnologia em Equipamentos e Materiais Eletricos Ltda, Campinas, SP (Brazil)

1991-12-31

170

Correlation of IHC and FISH for ALK gene rearrangement in non-small cell lung carcinoma: IHC score algorithm for FISH.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Accurate, cost-effective methods for testing anaplastic lymphoma kinase gene rearrangement (ALK+) are needed to select patients with non-small cell lung carcinoma for ALK-inhibitor therapy. Fluorescent in situ hybridization (FISH) is used to detect ALK+, but it is expensive and not routinely available. We explored the potential of an immunohistochemistry (IHC) scoring system as an affordable, accessible approach. METHODS: One hundred one samples were obtained from an enriched cohort of never-smokers with adenocarcinoma from the Mayo Clinic Lung Cancer Cohort. IHC was performed using the ALK1 monoclonal antibody with ADVANCE detection system (Dako) and FISH with dual-color, break-apart probe (Abbott Molecular) on formalin-fixed, paraffin-embedded tissue. RESULTS: Cases were assessed as IHC score 0 (no staining; n = 69), 1+ (faint cytoplasmic staining, n = 21), 2+ (moderate, smooth cytoplasmic staining; n = 3), or 3+ (intense, granular cytoplasmic staining in ?10% of tumor cells; n = 8). All IHC 3+ cases were FISH+, whereas 1 of 3 IHC 2+ and 1 of 21 IHC 1+ cases were FISH+. All 69 IHC 0 cases were FISH-. Considering FISH a gold-standard reference in this study, sensitivity and specificity of IHC were 90 and 97.8%, respectively, when 2+ and 3+ were regarded as IHC positive and 0 and 1+ as IHC negative. CONCLUSIONS: IHC scoring correlates with FISH and may be a useful algorithm in testing ALK+ by FISH in non-small cell lung carcinoma, similar to human epidermal growth factor-2 testing in breast cancer. Further study is needed to validate this approach.

Yi ES; Boland JM; Maleszewski JJ; Roden AC; Oliveira AM; Aubry MC; Erickson-Johnson MR; Caron BL; Li Y; Tang H; Stoddard S; Wampfler J; Kulig K; Yang P

2011-03-01

171

Relationship of SYNTAX Score to Myocardial Ischemia as Assessed on Myocardial Perfusion Imaging.  

UK PubMed Central (United Kingdom)

Background:?Although the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score is used to characterize coronary anatomy based on 9 anatomic criteria such as lesion location and complexity, the relationship between SYNTAX score and myocardial ischemia has yet to be elucidated. Methods and Results:?A total of 158 consecutive patients with suspected or known coronary artery disease (CAD), who underwent both (99m)Tc-sestamibi single-photon emission computed tomography (SPECT) and coronary angiography, were evaluated. Stress SPECT was assessed using a 17-segment model, and the percentage of the myocardial defect scores (DS) was calculated. In 37 patients with intermediate-high SYNTAX scores (>22), the number of men and the prevalence of multi-vessel CAD were significantly higher, and the % stress and ischemic DS were significantly greater than in 121 patients with low SYNTAX scores (?22). Coronary risk factors, however, were similar between the 2 groups. The % stress and ischemic DS significantly correlated with SYNTAX score. In patients with a low SYNTAX score, % stress and ischemic DS also significantly correlated with the SYNTAX score, whereas no such correlation was observed in the intermediate-high SYNTAX score group. Conclusions:?SYNTAX score correlated well with myocardial ischemia as assessed on stress SPECT in general. The higher the SYNTAX score, however, the less clear was the correlation with the extent of myocardial ischemia.

Tanaka H; Chikamori T; Hida S; Igarashi Y; Shiba C; Usui Y; Hatano T; Yamashina A

2013-08-01

172

Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70  

Directory of Open Access Journals (Sweden)

Full Text Available Michelle E Orme,1 Katherine S MacGilchrist,2 Stephen Mitchell,2 Dean Spurden,3 Alex Bird31Icera Consulting, Swindon, Wiltshire, UK; 2Systematic Review Department, Abacus International, Bicester, Oxfordshire, UK; 3Pfizer UK Limited, Tadworth, Surrey, UKBackground: Biologic disease-modifying antirheumatic drugs (bDMARDs) extend the treatment choices for rheumatoid arthritis patients with suboptimal response or intolerance to conventional DMARDs. The objective of this systematic review and meta-analysis was to compare the relative efficacy of EU-licensed bDMARD combination therapy or monotherapy for patients intolerant of or contraindicated to continued methotrexate.Methods: Comprehensive, structured literature searches were conducted in Medline, Embase, and the Cochrane Library, as well as hand-searching of conference proceedings and reference lists. Phase II or III randomized controlled trials reporting American College of Rheumatology (ACR) criteria scores of 20, 50, and 70 between 12 and 30 weeks' follow-up and enrolling adult patients meeting ACR classification criteria for rheumatoid arthritis previously treated with and with an inadequate response to conventional DMARDs were eligible. To estimate the relative efficacy of treatments whilst preserving the randomized comparisons within each trial, a Bayesian network meta-analysis was conducted in WinBUGS using fixed and random-effects, logit-link models fitted to the binomial ACR 20/50/70 trial data.Results: The systematic review identified 10,625 citations, and after a review of 2450 full-text papers, there were 29 and 14 eligible studies for the combination and monotherapy meta-analyses, respectively. In the combination analysis, all licensed bDMARD combinations had significantly higher odds of ACR 20/50/70 compared to DMARDs alone, except for the rituximab comparison, which did not reach significance for the ACR 70 outcome (based on the 95% credible interval). The etanercept combination was significantly better than the tumor necrosis factor-? inhibitors adalimumab and infliximab in improving ACR 20/50/70 outcomes, with no significant differences between the etanercept combination and certolizumab pegol or tocilizumab. Licensed-dose etanercept, adalimumab, and tocilizumab monotherapy were significantly better than placebo in improving ACR 20/50/70 outcomes. Sensitivity analysis indicated that including studies outside the target population could affect the results.Conclusion: Licensed bDMARDs are efficacious in patients with an inadequate response to conventional therapy, but tumor necrosis factor-? inhibitor combination therapies are not equally effective.Keywords: bDMARD, rheumatoid arthritis, etanercept, systematic review, network meta-analysis, comparative effectiveness

Orme ME; MacGilchrist KS; Mitchell S; Spurden D; Bird A

2012-01-01

173

Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70.  

UK PubMed Central (United Kingdom)

BACKGROUND: Biologic disease-modifying antirheumatic drugs (bDMARDs) extend the treatment choices for rheumatoid arthritis patients with suboptimal response or intolerance to conventional DMARDs. The objective of this systematic review and meta-analysis was to compare the relative efficacy of EU-licensed bDMARD combination therapy or monotherapy for patients intolerant of or contraindicated to continued methotrexate. METHODS: Comprehensive, structured literature searches were conducted in Medline, Embase, and the Cochrane Library, as well as hand-searching of conference proceedings and reference lists. Phase II or III randomized controlled trials reporting American College of Rheumatology (ACR) criteria scores of 20, 50, and 70 between 12 and 30 weeks' follow-up and enrolling adult patients meeting ACR classification criteria for rheumatoid arthritis previously treated with and with an inadequate response to conventional DMARDs were eligible. To estimate the relative efficacy of treatments whilst preserving the randomized comparisons within each trial, a Bayesian network meta-analysis was conducted in WinBUGS using fixed and random-effects, logit-link models fitted to the binomial ACR 20/50/70 trial data. RESULTS: The systematic review identified 10,625 citations, and after a review of 2450 full-text papers, there were 29 and 14 eligible studies for the combination and monotherapy meta-analyses, respectively. In the combination analysis, all licensed bDMARD combinations had significantly higher odds of ACR 20/50/70 compared to DMARDs alone, except for the rituximab comparison, which did not reach significance for the ACR 70 outcome (based on the 95% credible interval). The etanercept combination was significantly better than the tumor necrosis factor-? inhibitors adalimumab and infliximab in improving ACR 20/50/70 outcomes, with no significant differences between the etanercept combination and certolizumab pegol or tocilizumab. Licensed-dose etanercept, adalimumab, and tocilizumab monotherapy were significantly better than placebo in improving ACR 20/50/70 outcomes. Sensitivity analysis indicated that including studies outside the target population could affect the results. CONCLUSION: Licensed bDMARDs are efficacious in patients with an inadequate response to conventional therapy, but tumor necrosis factor-? inhibitor combination therapies are not equally effective.

Orme ME; Macgilchrist KS; Mitchell S; Spurden D; Bird A

2012-01-01

174

Quantitative analysis of multiparametric prostate MR images: differentiation between prostate cancer and normal tissue and correlation with Gleason score--a computer-aided diagnosis development study.  

UK PubMed Central (United Kingdom)

PURPOSE: To evaluate the potential utility of a number of parameters obtained at T2-weighted, diffusion-weighted, and dynamic contrast material-enhanced multiparametric magnetic resonance (MR) imaging for computer-aided diagnosis (CAD) of prostate cancer and assessment of cancer aggressiveness. MATERIALS AND METHODS: In this institutional review board-approved HIPAA-compliant study, multiparametric MR images were acquired with an endorectal coil in 48 patients with prostate cancer (median age, 62.5 years; age range, 44-73 years) who subsequently underwent prostatectomy. A radiologist and a pathologist identified 104 regions of interest (ROIs) (61 cancer ROIs, 43 normal ROIs) based on correlation of histologic and MR findings. The 10th percentile and average apparent diffusion coefficient (ADC) values, T2-weighted signal intensity histogram skewness, and Tofts K(trans) were analyzed, both individually and combined, via linear discriminant analysis, with receiver operating characteristic curve analysis with area under the curve (AUC) as figure of merit, to distinguish cancer foci from normal foci. Spearman rank-order correlation (?) was calculated between cancer foci Gleason score (GS) and image features. RESULTS: AUC (maximum likelihood estimate ± standard error) values in the differentiation of prostate cancer from normal foci of 10th percentile ADC, average ADC, T2-weighted skewness, and K(trans) were 0.92 ± 0.03, 0.89 ± 0.03, 0.86 ± 0.04, and 0.69 ± 0.04, respectively. The combination of 10th percentile ADC, average ADC, and T2-weighted skewness yielded an AUC value for the same task of 0.95 ± 0.02. GS correlated moderately with 10th percentile ADC (? = -0.34, P = .008), average ADC (? = -0.30, P = .02), and K(trans) (? = 0.38, P = .004). CONCLUSION: The combination of 10th percentile ADC, average ADC, and T2-weighted skewness with CAD is promising in the differentiation of prostate cancer from normal tissue. ADC image features and K(trans) moderately correlate with GS.

Peng Y; Jiang Y; Yang C; Brown JB; Antic T; Sethi I; Schmid-Tannwald C; Giger ML; Eggener SE; Oto A

2013-06-01

175

Acetabulum protrusio and center edge angle: new MR-imaging measurement criteria - a correlative study with measurement derived from conventional radiography  

International Nuclear Information System (INIS)

The goal of this study was to identify a method of measurement for acetabulum protrusio and center edge angle (CEA) using MR imaging of the pelvis that correlated with classic methods using radiographic landmarks. MR images and radiographs of the pelvis in 67 patients (132 hips) were used to identify reliable MR-imaging methods for measuring protrusio acetabulum and CEA that correlated strongly with established radiographic measurements. Protrusio acetabulum was determined using the radiographic criterion that the acetabular line projects medial to the ilioischial line by 3 mm or more in men and 6 mm or more in women. Pearson correlation factor was used to determine inter-observer variability and those methods that demonstrated the strongest correlation. The mean and standard deviation of MR-imaging and radiographic measurements for both the normal and protrusio hips were established. Several MR methods correlated strongly with radiographic measurements. The preferred method employed axial MR images at the level of the ischial spine with measurement of the distance between the medial most point of the acetabular fossa and a line perpendicular to the horizontal axis that passed through the lateral margin of the posterior inner pelvic wall. The Pearson's correlation factor between radiographic and MR measurements using this method was 0.84, and inter-observer correlation was 0.80. There were 126 hips in 63 patients (17 female and 44 male) that did not meet the radiographic criteria for protrusio acetabula. In this group of normal hips, the mean and standard deviation of radiographic measurements were 1.9 and 2.8 mm in male patients and -0.5 and 1.7 mm in female patients, and the mean and standard deviation for the preferred MR method was 1.3 and 2.5 mm in male patients and -0.8 and 1.9 mm in female patients. A total of six hips in four patients (two female and two male) met the radiographic criteria for protrusio acetabula. In this group of patients, the mean and standard deviation of radiographic measurements were -3.7 and 1 mm in male patients and -5.4 and 0.9 mm in female patients, and the mean and standard deviation for the preferred MR method was -4.1 and 0.4 mm in male patients and -6.5 and 0.3 mm in female patients. Our study also showed that the CEA was best measured using anterior to middle coronal MR images. Posterior coronal MR-imaging measurements correlated poorly with radiographic measurements. MR imaging can be used to assess acetabular morphology and measure acetabulum protrusio. (orig.)

2009-01-01

176

Correlação da técnica bottom turn com as notas atribuídas no surf de alto rendimento/ Correlation of the bottom turn technique with the scores attributed in high performance surfing  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese As competições de surf no cenário mundial têm apresentado um alto e homogêneo nível de desempenho entre os atletas. Assim, atentou-se à hipótese de que o bottom turn (BT), curva na base da onda essencial para a construção de manobras subsequentes, pode afetar os resultados alcançados em baterias de surf de alto rendimento. O estudo teve como objetivo quantificar o tempo que os atletas levam na execução de BT em suas ondas e correlacioná-lo com as notas atrib (more) uídas. A amostra foi composta por quatro eventos do World Tour de Surf, sendo avaliadas 4 baterias de cada evento, perfazendo um total de 16 baterias investigadas. A análise de cada BT foi realizada por meio do recurso de corte de vídeo disponível no programa Sony Vegas Pro 10.0. A análise estatística foi implementada no software SPSS 18.0, sendo calculado o coeficiente de correlação de Pearson, com nível de significância de p Abstract in english The surf contests worldwide have presented a high and homogeneous level of performance by the athletes. Thus, the hypothesis that the bottom turn (BT), curve on the base of the wave which is essential to the construction of subsequent maneuvers, might influence the results in high performance competitions. The objective of this study was to quantify the time taken in the execution of the BT by the athletes and correlate it to the scores awarded. The research sample was co (more) mposed of four contests of the Surfing World Tour. Four heats of each contest were assessed, in a total of sixteen heats studied. The analysis of each BT was performed by using the video split feature available in the Sony Vegas Pro 10.0 software. The statistic analysis was performed with the software SPSS 18.0. The Pearson correlation coefficient was calculated with a significance level of p

Souza, Pedro Caetano; Rocha, Marcos Augusto; Nascimento, Juarez Vieira do

2012-01-01

177

Urine TMPRSS2:ERG fusion transcript integrated with PCA3 score, genotyping, and biological features are correlated to the results of prostatic biopsies in men at risk of prostate cancer.  

UK PubMed Central (United Kingdom)

BACKGROUND: Detection of fusion gene TMPRSS2:ERG transcripts in urine have been recently described in order to refine urine-based detection of prostate cancer (PCa), but data its clinical impact remain scarce. We aimed at investigating the correlation of TMPRSS2:ERG, prostate cancer antigen 3 (PCA3), prostate specific antigen (PSA) density, genetic variants, and androgenic status with outcome and pathological findings at prostatic biopsy. METHODS: Between 2007 and 2011, 291 patients at risk of PCa because of PSA?>?3.0?ng/ml (55%) or candidate to active surveillance protocol justifying restaging biopsy management (45%) were recruited. TMPRSS2:ERG was detected by urine assay (Progensa™). PCA3-score, PSA level, bioavailable testosterone level, prostate volume, rs1447295 and rs6983267 genotypes were prospectively assessed. Univariate and multivariate analysis by logistic regression model (logit) were conducted to study the correlation of TMPRSS2:ERG status, PCA3, and PSA density with biopsy results, and Gleason score. RESULTS: Of 291 patients, 173 had PCa and 118 had negative biopsy. PCA3 score, PSA density and TMPRSS2:ERG-score were correlated with presence of PCa (P?correlation remained strong on multivariable analysis model (area under curve 0.743). PCA3 score and PSA density were significantly associated with presence of Grade 4 through multivariable analysis. PCA3 score was also correlated to the percentage of positive cores at biopsy (P?=?0.008). CONCLUSIONS: Integration of levels TMPRSS2:ERG transcripts in urine, with PCA3-score, androgenic status, genetic status and traditional clinical variables could significantly increase detection of high risk localized PCa.

Cornu JN; Cancel-Tassin G; Egrot C; Gaffory C; Haab F; Cussenot O

2013-02-01

178

Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics  

Directory of Open Access Journals (Sweden)

Full Text Available There is critical need for improved biomarker assessment platforms which integrate traditional pathological parameters (TNM stage, grade and ER/PR/HER2 status) with molecular profiling, to better define prognostic subgroups or systemic treatment response. One roadblock is the lack of semi-quantitative methods which reliably measure biomarker expression. Our study assesses reliability of automated immunohistochemistry (IHC) scoring compared to manual scoring of five selected biomarkers in a tissue microarray (TMA) of 63 human breast cancer cases, and correlates these markers with clinico-pathological data. TMA slides were scanned into an Ariol Imaging System, and histologic (H) scores (% positive tumor area x staining intensity 0–3) were calculated using trained algorithms. H scores for all five biomarkers concurred with pathologists’ scores, based on Pearson correlation coefficients (0.80–0.90) for continuous data and Kappa statistics (0.55–0.92) for positive vs. negative stain. Using continuous data, significant association of pERK expression with absence of LVI (p = 0.005) and lymph node negativity (p = 0.002) was observed. p53 over-expression, characteristic of dysfunctional p53 in cancer, and Ki67 were associated with high grade (p = 0.032 and 0.0007, respectively). Cyclin D1 correlated inversely with ER/PR/HER2-ve (triple negative) tumors (p = 0.0002). Thus automated quantitation of immunostaining concurs with pathologists’ scoring, and provides meaningful associations with clinico-pathological data.

Jamaica D. Cass; Sonal Varma; Andrew G. Day; Waheed Sangrar; Ashish B. Rajput; Leda H. Raptis; Jeremy Squire; Yolanda Madarnas; Sandip K. SenGupta; Bruce E. Elliott

2012-01-01

179

The correlation of research diagnostic criteria for temporomandibular disorders and magnetic resonance imaging: a study of diagnostic accuracy.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The aim of this study was to evaluate the performance of research diagnostic criteria for temporomandibular disorders (RDC/TMD) as a diagnostic test for temporomandibular joint problems using magnetic resonance imaging (MRI) as the gold standard. STUDY DESIGN: Sixty-seven women were assessed with RDC/TMD (2 examiners) and underwent MRI examination (3.0 T). Images were evaluated by 2 independent radiologists blinded to the clinical diagnoses. Results were analyzed by the Catmaker system. RESULTS: Of the 67 patients, 44 were diagnosed with temporomandibular disorders (TMD) according to RDC/TMD, but 21 (32%) of the diagnoses were not confirmed by MRI. The RDC/TMD sensitivity was 83.0%, specificity was 53.0%, and the positive likelihood ratio was 1.77, whereas the negative likelihood ratio was 0.32 (P = 0.16). CONCLUSIONS: Our data suggest that RDC/TMD is a good research tool, but the high rate of false-positive results limits its use in clinical practice.

Galhardo AP; da Costa Leite C; Gebrim EM; Gomes RL; Mukai MK; Yamaguchi CA; Bernardo WM; Soares JM Jr; Baracat EC; Gil C

2013-02-01

180

An Exploratory Analysis of the Correlation of Pain Scores, Patient Satisfaction With Relief From Pain, and a New Measure of Pain Control on the Total Dose of Opioids in Pain Care.  

UK PubMed Central (United Kingdom)

OBJECTIVE:: We explored the associations between opioid dose and multiple measures of pain. STUDY DESIGN AND MEASURES:: Thirty-two consecutive patients admitted solely for an acute exacerbation of cancer-related pain or for surgery were followed for their entire hospital stay (115 days of pain). For each hospital day, we collected pain scores, the number of pain scores, trends in pain scores, the percentage of time patients had 100% acceptable relief from pain, and the number of times patients were asked about acceptable pain relief. Finally, we asked those who had 100% relief of pain whether they could have used more pain medicine. Linear regression models were fit to estimate the amount of variation explained (R) in dose of medication, by each pain measurement variable. RESULTS:: Nineteen patients with cancer (74 days of pain) and 13 patients undergoing surgery (41 days of pain) were evaluated. Pain scores, the number of pain scores, trends in pain scores, and 100% acceptable relief scores poorly correlated with the use of medication in the linear regression models (R for all models ?0.2). A question about needing more pain medicine explained the greatest amount of variation in opioid dose. CONCLUSIONS:: Pain and acceptable relief scores do not adequately reflect the use of medication. A prospective study is needed to further assess the value of additional measures of the adequacy of pain care.

Harting B; Johnson T; Abrams R; Odwazny R; Hasler S; McNutt R

2013-10-01

 
 
 
 
181

A Validation Study of the International Consensus Diagnostic Criteria for Neuroleptic Malignant Syndrome.  

UK PubMed Central (United Kingdom)

Neuroleptic malignant syndrome requires prompt recognition for effective management, but there is a lack of reliable diagnostic criteria. This study is the first attempt to validate the recently published international consensus diagnostic criteria, which include a scoring system that assigns clinical priority points to each criterion according to its importance in making a diagnosis of neuroleptic malignant syndrome. Data were extracted from 229 archived contact reports of clinician-initiated calls to a national telephone consultation service between 1997 and 2007. International consensus criteria were used to assign a total priority-point score to each case. Cases were also diagnosed with the use of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR, American Psychiatric Association, 2000) research criteria, which served as the diagnostic reference standard. Receiver operating characteristic curve analysis was used to identify the cutoff in the priority-point score associated with maximal diagnostic efficiency. The area under the receiver operating characteristic curve was equal to 0.933 (95% confidence interval, 0.903-0.963). A cutoff score of 64 (maximum, 100) was associated with a sensitivity of 83.2% and a specificity of 94.6%. There were 15.1% more cases diagnosed with the use of the DSM-IV-TR criteria than those with the use of consensus criteria cutoff score (137 vs 119 cases; ?1 = 133.38, P = 0.000). The priority-point value assigned to each criterion by the consensus panel was significantly correlated with its prevalence in the high-score group (r = 0.909, n = 7, P = 0.005). In summary, the consensus diagnostic criteria demonstrated high concurrent criterion validity with respect to the DSM-IV-TR criteria, and the consensus priority-point scores predicted the observed frequencies of these criteria in this telephone contact sample. Pending additional validation, the consensus diagnostic criteria should be considered only adjunctive to the current clinical practice.

Gurrera RJ; Velamoor V; Cernovsky ZZ

2013-08-01

182

The Impact of Overreporting on MMPI-2-RF Substantive Scale Score Validity  

Science.gov (United States)

This study examined the impact of overreporting on the validity of Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) substantive scale scores by comparing correlations with relevant external criteria (i.e., validity coefficients) of individuals who completed the instrument under instructions to (a) feign psychopathology…

Burchett, Danielle L.; Ben-Porath, Yossef S.

2010-01-01

183

Correlation of CHADS2 and CHA2DS2-VASc scores with transesophageal echocardiography risk factors for thromboembolism in a multiethnic United States population with nonvalvular atrial fibrillation.  

UK PubMed Central (United Kingdom)

BACKGROUND: The aims of this study were to evaluate the relationship of the CHA(2)DS(2)-VASc score and risk categories with transesophageal echocardiographic (TEE) risk factors for thromboembolism and to compare the CHA(2)DS(2)-VASc and CHADS(2) risk stratification schemes with respect to their ability to predict these risk factors in a multiethnic US population with nonvalvular atrial fibrillation. METHODS: Transesophageal echocardiograms of 167 patients (mean age, 66.3 ± 11.6 years; 146 men [87%]; 100 whites [60%]; 40 Hispanics [24%]; 27 blacks [16%]) with nonvalvular atrial fibrillation were retrospectively reviewed for smoke, sludge, thrombus, and left atrial appendage (LAA) emptying velocity ?20 cm/sec. The patients' CHA(2)DS(2)-VASc and CHADS(2) risk scores and categories were also calculated. RESULTS: Any LAA abnormality, smoke, sludge, thrombus, and abnormal LAA emptying velocity were present in 45%, 38%, 13%, 3%, and 22% of patients, respectively. Heart failure (P < .001), age (P < .001 for age ?75 vs ?64 years, P = .013 for age 65-74 vs ?64 years), and diabetes (P = .019) were independent predictors of LAA abnormalities, while ethnicity was not. The prevalence of TEE risk factors for thromboembolism increased with increasing CHA(2)DS(2)-VASc score and risk category. The CHADS(2) risk categories of 35 patients (21%) were upgraded by the CHA(2)DS(2)-VASc scheme. Using the latter scheme, fewer patients were classified as at intermediate risk compared with the CHADS(2) system (21 [13%] vs 46 [28%]). Patients classified as at low risk by either scheme had almost no TEE risk factors. Of 30 intermediate-risk patients by CHADS(2) score upgraded to high risk using CHA(2)DS(2)-VASc score, eight (27%) had at least one TEE risk factor for thromboembolism. C-statistics, sensitivity, and specificity for predicting any LAA abnormality were 0.607 (95% confidence interval, 0.549-0.665), 92.0%, and 28.9% for CHA(2)DS(2)-VASc score and 0.685 (95% confidence interval, 0.615-0.755), 81.3%, and 54.2% for CHADS(2) score. CONCLUSIONS: CHA(2)DS(2)-VASc score is associated with TEE risk factors for thromboembolism in a multiethnic US population. Compared with CHADS(2) score, it has increased sensitivity, decreased specificity, and lower ability for predicting TEE risk factors in this population.

Willens HJ; Gómez-Marín O; Nelson K; DeNicco A; Moscucci M

2013-02-01

184

Correlations between FDG PET glucose uptake-MRI gray matter volume scores and apolipoprotein E ?4 gene dose in cognitively normal adults: a cross-validation study using voxel-based multi-modal partial least squares.  

UK PubMed Central (United Kingdom)

We previously introduced a voxel-based, multi-modal application of the partial least square algorithm (MMPLS) to characterize the linkage between patterns in a person's complementary complex datasets without the need to correct for multiple regional comparisons. Here we used it to demonstrate a strong correlation between MMPLS scores to characterize the linkage between the covarying patterns of fluorodeoxyglucose positron emission tomography (FDG PET) measurements of regional glucose metabolism and magnetic resonance imaging (MRI) measurements of regional gray matter associated with apolipoprotein E (APOE) ?4 gene dose (i.e., three levels of genetic risk for late-onset Alzheimer's disease (AD)) in cognitively normal, late-middle-aged persons. Coregistered and spatially normalized FDG PET and MRI images from 70% of the subjects (27 ?4 homozygotes, 36 ?4 heterozygotes and 67 ?4 non-carriers) were used in a hypothesis-generating MMPLS analysis to characterize the covarying pattern of regional gray matter volume and cerebral glucose metabolism most strongly correlated with APOE-?4 gene dose. Coregistered and spatially normalized FDG PET and MRI images from the remaining 30% of the subjects were used in a hypothesis-testing MMPLS analysis to generate FDG PET-MRI gray matter MMPLS scores blind to their APOE genotype and characterize their relationship to APOE-?4 gene dose. The hypothesis-generating analysis revealed covarying regional gray matter volume and cerebral glucose metabolism patterns that resembled those in traditional univariate analyses of AD and APOE-?4 gene dose and PET-MRI scores that were strongly correlated with APOE-?4 gene dose (p<1 × 10(-16)). The hypothesis-testing analysis results showed strong correlations between FDG PET-MRI gray matter scores and APOE-?4 gene dose (p = 8.7 × 10(-4)). Our findings support the possibility of using the MMPLS to analyze complementary datasets from the same person in the presymptomatic detection and tracking of AD.

Chen K; Ayutyanont N; Langbaum JB; Fleisher AS; Reschke C; Lee W; Liu X; Alexander GE; Bandy D; Caselli RJ; Reiman EM

2012-05-01

185

The relationship between second-year medical students' OSCE scores and USMLE Step 1 scores.  

Science.gov (United States)

The relationship between objective structured clinical examinations (OSCEs) and standardized tests is not well known. We linked second-year medical students' physical diagnosis OSCE scores from 1998, 1999 and 2000 (n = 355) with demographic information, Medical College Admission Test (MCAT) scores, and United States Medical Licensing Examination (USMLE) Step 1 scores. The correlation coefficient for the total OSCE score with USMLE Step 1 score was 0.41 (p < 0.001). Two of 7 skills areas-diagnosis and identification of abnormality-were significant multivariate correlates of USMLE Step 1 score. OSCE station scores accounted for approximately 22% of the variability in USMLE Step 1 scores. A second-year OSCE in physical diagnosis is correlated with scores on the USMLE Step 1 exam, with skills that foreshadow the clinical clerkships most predictive of USMLE scores. This correlation suggests predictive validity of this OSCE and supports the use of OSCEs early in medical school. PMID:12450476

Simon, Steven R; Volkan, Kevin; Hamann, Claus; Duffey, Carol; Fletcher, Suzanne W

2002-09-01

186

Correlation between computer-aided dynamic gadolinium-enhanced MRI assessment of inflammation and semi-quantitative synovitis and bone marrow oedema scores of the wrist in patients with rheumatoid arthritis--a cohort study  

DEFF Research Database (Denmark)

Objective. To test the correlation between assessment of inflammation using dynamic contrast-enhanced MRI (DCE-MRI) analysed by a novel computer-aided approach and semi-quantitative scores of synovitis and bone marrow oedema (BME) using the OMERACT-RA MRI Scoring (RAMRIS) system, in the wrist of patients with RA. Methods. Fifty-four RA patients had conventional and DCE-MRI of a symptomatic wrist using a low-field 0.2T extremity scanner. RAMRIS synovitis and BME of the wrist joint were done. DCE-MRI data were analysed in three ways: (i) in all images (fully automated approach), (ii) within a large extended region of interest (ROI) placed around the wrist joint (semi-automated approach) and (iii) within a small ROI placed in the area with most visual enhancement (semi-automated approach). Time spent on each procedure was noted. Spearman's rank correlation test was applied to assess the correlation between RAMRIS and the computer-generated dynamic parameters. Results. RAMRIS synovitis (range 2-9), BME (range 0-39) and the dynamic parameters reflecting the number of enhancing voxels were significantly correlated, especially when an extended ROI around the wrist was used (¿¿=¿0.74; P¿

Boesen, Mikael; Kubassova, Olga

2012-01-01

187

Discriminating malaria from dengue Fever in endemic areas: clinical and biological criteria, prognostic score and utility of the C-reactive protein: a retrospective matched-pair study in French Guiana.  

UK PubMed Central (United Kingdom)

BACKGROUND: Dengue and malaria are two major public health concerns in tropical settings. Although the pathogeneses of these two arthropod-borne diseases differ, their clinical and biological presentations are unspecific. During dengue epidemics, several hundred patients with fever and diffuse pain are weekly admitted at the emergency room. It is difficult to discriminate them from patients presenting malaria attacks. Furthermore, it may be impossible to provide a parasitological microscopic examination for all patients. This study aimed to establish a diagnostic algorithm for communities where dengue fever and malaria occur at some frequency in adults. METHODOLOGY/PRINCIPAL FINDINGS: A sub-study using the control groups of a case-control study in French Guiana - originally designed to compare dengue and malaria co-infected cases to single infected cases - was performed between 2004 and 2010. In brief, 208 patients with malaria matched to 208 patients with dengue fever were compared in the present study. A predictive score of malaria versus dengue was established using .632 bootstrap procedures. Multivariate analysis showed that male gender, age, tachycardia, anemia, thrombocytopenia, and CRP>5 mg/l were independently associated with malaria. The predictive score using those variables had an AUC of 0.86 (95%CI: 0.82-0.89), and the CRP was the preponderant predictive factor. The sensitivity and specificity of CRP>5 mg/L to discriminate malaria from dengue were of 0.995 (95%CI: 0.991-1) and 0.35 (95%CI 0.32-0.39), respectively. CONCLUSIONS/SIGNIFICANCE: The clinical and biological score performed relatively well for discriminating cases of dengue versus malaria. Moreover, using only the CRP level turned to be a useful biomarker to discriminate feverish patients at low risk of malaria in an area where both infections exist. It would avoid more than 33% of unnecessary parasitological examinations with a very low risk of missing a malaria attack.

Epelboin L; Boullé C; Ouar-Epelboin S; Hanf M; Dussart P; Djossou F; Nacher M; Carme B

2013-01-01

188

The examination of the relationship between YGS scores and music field scores in music teaching programme with special talent examination  

Directory of Open Access Journals (Sweden)

Full Text Available Every year, with special aptitude exams students are taken to undergraduate programs as a music teacher in Turkey .Although applications for these exam show differences according to the difficulty level of the questions and evaluations criterias, all the areas that would be measured show similarities to each other. The areas showing the similarity are classified as Musical hearing-reading-writing fields (M?OY) , musical playing area and musical singing area. Special Ability Test score (ÖYSP) Transition to Higher Education Exam scores, as well as forming the points (YGS-P) and the weighted scores of Secondary Education (AOBP) takes place mainly among the scores of the candidates. It is used according to the circumstances of different coefficients Placement Scores (YP) in the calculation. The types of score that form YGS-P and ÖYS, which mainly affect the placemet of the students to the university, the relationship between the musical areas in ÖYSP and all correlations of the areas to each other have been seen as a basical problem of this study.761 candidates who auditioned for Music Education Program in the years 2010-2011 and 2011-2012 academic Inonu University Faculty of Education constitutes the study group . As a result of the analysis made, between the M?OY scores and YGS-P there is a meaningful relationship in positive direction and low level (r =. 08, p <. 05) In adddition, There are positive correlation and low level (r=.32, p<.01); between the musical play and M?OY area points, playing field between the musical scores of M?OY there are positive direction, the low level (r = .21, p <.05) relationship, and it has been found that there is meaningful relationship between musical play area and the Musical direction at a high level. (r=.79, p<.01)

Turan Sa?er; Onur Zahal; Engin Gürp?nar

2013-01-01

189

Rape Myth Acceptance, Hypermasculinity, and SAT Scores as Correlates of Moral Development: Understanding Sexually Aggressive Attitudes in First-Year College Men  

Science.gov (United States)

Male perpetrated sexual aggression has long been recognized as a serious problem on college campuses. The purpose of this multiple regression correlation study was to assess the relationship between levels of moral development (measured by the Defining Issues Test) and the degree to which first-year college men (N = 161) ascribed to rape…

Tatum, Jerry L.; Foubert, John D.

2009-01-01

190

A Simple Clinical Score “TOPRS” to Predict Outcome in Pediatric Emergency Department in a Teaching Hospital in India  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To develop a simple clinical scoring system for severity of illness to help prioritize care and predict outcome in emergency department.Methods: Prospective hospital based observational study. Out of a total of 874 children who attended emergency department in one year, 777 were included in the study. Data was collected at the time ofadmission in emergency department. The baseline information like age, gender, etc and variables of ‘toprs’score viz temperature, oxygen saturation, pulse rate, respiratory rate, sensorium and seizures were recorded.Variables were categorized as normal (score zero) or abnormal (score 1) based on systemic inflammatory response syndrome (SIRS) criteria and criteria mentioned in advanced pediatric life support (APLS) and the total scores were computed for each child. The outcome (death/discharge) was correlated with the studyvariables and total score. The predictive ability of score was calculated using receiver operating characteristic (ROC) curve analysis.Findings: Of the six variables, temperature, oxygen saturation and respiratory rate were found to be significantly associated with mortality. Mortality increased with the increase in the number of abnormal variables. Based on the regression coefficients, maximum possible score was 6.68. The predictive ability of score was 81.7 calculated using ROC curve. Maximum discrimination was observed at a score of 2.5.Conclusion: For triage in emergency, any patient with 2 or more abnormal variables should be closely monitored and evaluated. These patients require admission as they have a potential risk of death.

2012-01-01

191

Correlações genéticas entre escores visuais e características de carcaça medidas por ultrassom em bovinos de corte Genetic correlations between visual scores and carcass traits measured by real-time ultrasound in beef cattle  

Directory of Open Access Journals (Sweden)

Full Text Available O objetivo deste trabalho foi estimar correlações genéticas e fenotípicas entre escores visuais e características de carcaça medidas por ultrassom, para verificar a eficácia desses escores na determinação da musculosidade e na avaliação da carcaça. As características de carcaça medidas por ultrassom foram área de olho de lombo (AOL) e espessura de gordura subcutânea (EG), mensuradas entre a região da 12ª e 13ª costelas, bem como a espessura de gordura subcutânea na garupa (EGP8). As características de estrutura (E), precocidade (P) e musculosidade (M) foram avaliadas por meio de escores visuais. Os componentes de covariância usados para estimar as correlações genéticas e fenotípicas foram obtidos pelo método da máxima verossimilhança restrita, em uma análise multicaracterística. As estimativas de correlações genéticas entre AOL e E, P e M foram 0,54, 0,58 e 0,61, respectivamente, e indicaram que, a longo prazo, a utilização da AOL como critério de seleção poderá produzir animais com maiores escores visuais para essas características. As correlações genéticas estimadas entre as espessuras de gordura (EG e EGP8) e os escores P e M apresentaram comportamento semelhante. Entretanto, as correlações genéticas entre as espessuras de gordura (EG e EGP8) e E foram próximas de zero. As correlações fenotípicas seguiram as mesmas tendências das respectivas correlações genéticas. Essas estimativas indicam que os escores visuais são determinados, em parte, pelos mesmos conjuntos de genes que influenciam a AOL.The aim of this work was to evaluate the genetic and phenotypic correlations between carcass traits measured by real-time ultrasound and by visual scores, in order to verify the effectiveness of these scores in determining muscularity and carcass fat. Carcass traits measured by real-time ultrasound were longissimus muscle area (LMA) and backfat thickness (BF), obtained between the 12th and 13th ribs, as well as the rump fat thickness (RF). The visual scores for the traits of body structure (E), precocity (P), and muscle (M) were evaluated individually. The genetic and phenotypic parameters were estimated by multivariate analysis, using restricted maximum likelihood methodology. The estimated genetic correlations between LMA and E, P and M were 0.54, 0.58 and 0.61, respectively, indicating that, in the long term, the use of LMA as a selection criterion might produce animals with higher visual scores. Similar genetic correlations were found between both subcutaneous fat measures (BF and RF) and P and M scores. However, genetic correlations between both subcutaneous fat measures and E were close to zero. The phenotypic correlations followed the same trends of their respective genetic correlations. These estimates indicate that the visual scores and LMA are, in part, determined by the same groups of genes.

Marcos Jun Iti Yokoo; Juliana Nunes Werneck; Márcio Cinachi Pereira; Lucia Galvão de Albuquerque; William Koury Filho; Roberto Daniel Sainz; Raysildo Barbosa Lobo; Fabiano Rodrigues da Cunha Araujo

2009-01-01

192

Correlation of serum ?2-microglobulin levels with prostate-specific antigen, Gleason score, clinical stage, tumor metastasis and therapy efficacy in prostate cancer.  

UK PubMed Central (United Kingdom)

BACKGROUND AND AIMS: Despite previous reports implying a role of ?2-microglobulin (?2M) in the development of prostate cancer (PCa), the correlation of serum ?2M with the clinicopathological features, therapy efficacy and prognosis of patients with PCa have not been fully clarified. The present study aims to investigate the serum levels of ?2M in patients with PCa and explore the potential use of ?2M as a tumor marker for diagnosis, treatment and prognosis of PCa. METHODS: Serum ?2M levels in 120 patients with PCa, 50 patients with benign prostate hyperplasia (BPH) and 85 healthy age-matched controls were measured by enzyme immunoassay. The correlation of serum ?2M with the clinicopathological features, therapy efficacy and the prognosis of PCa were subsequently assessed. RESULTS: Our results showed that: (i) PCa patients had significantly higher levels of ?2M compared to those of patients with BPH or those of healthy controls. (ii) Serum ?2M were markedly elevated in patients with high stage or grade PCa as compared to patients with low stage or grade PCa. (iii) We measured significantly higher levels of ?2M in patients with metastasis as compared to patients lacking metastasis. (iv) During follow-up, serum ?2M showed a marked decrease after successful therapy and a significant further increase in recurrent disease. CONCLUSIONS: Our results demonstrate that serum ?2M is correlated closely with the clinical stage, Gleason grade, PSA, distant metastasis and therapy efficacy in patients with PCa. Serum ?2M may be a useful biomarker for clinical diagnosis, follow-up and prognosis of PCa.

Zhang YX; Wang L; Ji PY; Zhao GG; Zhong GP; Wang ZP

2013-05-01

193

Mangled lower extremity: can we trust the amputation scores?  

Science.gov (United States)

Background Limb injuries represent a constant and severe problem. Several lower limb injuries are more frequent than upper limb injuries. Over time, in an attempt to quantify the severity of traumas and to establish guidelines for the decision whether to save or amputate a mangled extremity, several scoring systems have been reported. Most refer to bone fractures, soft tissue damage, vascular, nerves and tendon lesions. Matherials and methods Articles dealing with mangled lower extremities published in the last 15 years were analyzed. Other inclusion criteriaincluded:articles reporting MESS, PSI, LSI, and Gustillo-Anderson scores, studies based on groups of more than 25 patients, and English language articles. We tried to determine if there was good correlation between amputation recommendations and various scores of injury, with regard to combat wounds and civilian injuries, in adult and pediatric groups. Results Thirty-two papers fulfilled our criteria; in 17 of these, correlation between mangled extremity scores and the decision to amputate or salvage the limb was well-defined. Good correlation between MESS and amputation was found in 25% of the papers. The highest correlation was found for pediatric injuries and combined adult and pediatric combat injuries. Conclusions The mangled extremity is a long-lasting, unsolved problem, with much debate and a large number of protocols and scoring systems, but with no unanimously-accepted solution. Many mangled extremities are borderline cases, and the decision to amputate or to salvage a limb must be carefully assessed. With advances in the medical field over the last 15 years, more mangled lower extremities are salvaged, especially in civilian injuries.

Fodor, Lucian; Sobec, Raluca; Sita-Alb, Laura; Fodor, Marius; Ciuce, Constantin

2012-01-01

194

Correlação de três variáveis na descrição da permeabilidade nasal (HD, MCA, escala NOSE) de pacientes saudáveis/ Correlation of three variables describing nasal patency (HD, MCA, NOSE score) in healthy subjects  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Rinoresistometria e rinometria acústica são dois métodos utilizados na avaliação da função respiratória nasal. Ambos utilizam variáveis diferentes para descrever a permeabilidade nasal: o diâmetro hidráulico, HD, na rinoresistometria; e as áreas mínimas da seção transversal, MCA1 (istmo nasal) e MCA2 (cabeça do corneto inferior e corpo cavernoso do septo nasal), na rinometria acústica. OBJETIVO: Analisar a relação entre HD e MCA em pacientes sem afecç? (more) ?es nasais e identificar se tais variáveis objetivas apresentam correlação com a escala NOSE, uma ferramenta validada para avaliar a percepção subjetiva de permeabilidade nasal. MÉTODO: Coleta estruturada dos dados de 24 indivíduos saudáveis sem afecções nasais. RESULTADOS: Correlações estatisticamente significativas de fracas a moderadas foram identificadas entre HD e MCA2 antes do descongestionamento. Foi identificada correlação moderada entre HD, MCA2 e escala NOSE no lado mais estreito. CONCLUSÃO: Na avaliação de permeabilidade nasal, parece ser recomendável determinar HD, MCA1 e MCA2, bem como uma variável subjetiva como a escala NOSE, que não aparentam ser variáveis completamente redundantes. Estudos futuros devem avaliar a correlação destas variáveis em pacientes com afecções nasais. Abstract in english Rhinoresistometry and acoustic rhinometry are two established apparative methods to objectify the respiratory function of the nose. Both methods use different variables to describe nasal patency: "hydraulic diameter", HD, in rhinoresistometry, and "minimal cross-sectional area", MCA1 (nasal isthmus) and MCA2 (head of the inferior turbinate and cavernous body of the nasal septum), in acoustic rhinometry. OBJECTIVE: This study analyzes the mutual correlation of HD and MCA a (more) s a pilot study in patients without nasal pathologies. Additionally, we investigated if these objective variables correlate with the NOSE score, a validated tool to measure subjective perception of nasal patency. METHOD: Planned data collection in a collective of 24 healthy subjects without nasal pathologies. RESULTS: Statistically significant, weak to moderate correlations were found between HD and MCA2 before decongestion. A moderate correlation was found between both HD and MCA2 and the NOSE score on the narrower side. CONCLUSION: In the assessment of nasal patency, it seems advisable to determine HD, MCA1 and MCA2, but also a subjective variable such as the NOSE score, which all seem to be not fully redundant variables. In further studies, the correlation of the variables should be assessed in patients with nasal pathologies.

Braun, Thomas; Rich, Maria; Kramer, Matthias F.

2013-06-01

195

Correlation of serum levels of complement C4a desArg with pathologically estimated severity of glomerular lesions and mesangial hypercellularity scores in patients with IgA nephropathy.  

UK PubMed Central (United Kingdom)

The aim of the present study was to explore serum biomarkers for the pathology of IgA nephropathy using serum proteomics. The subjects were 57 patients with IgA nephropathy who were divided into two groups (group 1, n=25; group 2, n=32) and 14 healthy controls. Serum protein profiles were analyzed using the ProteinChip surface-enhanced laser desorption ionization (SELDI) system. Associations between signal intensities of proteins and histological findings in patients with IgA nephropathy were studied in group 1. Serum levels of a candidate biomarker protein (complement component C4a desArg) for IgA nephropathy were determined by enzyme linked-immunosorbent assay (ELISA) in group 2 and the relationships of these levels with histological findings were evaluated. There were significant differences in 93 protein signals between patients in group 1 and controls. Among these signals, 3 proteins at 8592, 8757 and 8806 m/z were significantly correlated with the severity of glomerular lesions. The protein at 8592 m/z was identified as C4a desArg and the signal intensity of 8592 m/z was strongly correlated with serum C4a levels, including C4a desArg, determined by ELISA. In addition, the serum levels of C4a (mainly C4a desArg) were significantly higher in patients in group 2 compared to controls and were correlated with the severity of glomerular lesions and with mesangial hypercellularity scores. In conclusion, the serum levels of complement C4a desArg are significantly higher in patients with IgA nephropathy compared to healthy controls and are significantly correlated with the severity of glomerular lesions and mesangial hypercellularity scores. Thus, serum C4a desArg is a potential biomarker for the severity of histological findings in patients with IgA nephropathy.

Sogabe A; Uto H; Kanmura S; Nosaki T; Oyamada M; Tokunaga K; Nishida C; Fukumoto M; Oku M; Nishimoto K; Takenouchi S; Ido A; Shimada Y; Tsubouchi H

2013-05-01

196

Correlation of serum levels of complement C4a desArg with pathologically estimated severity of glomerular lesions and mesangial hypercellularity scores in patients with IgA nephropathy.  

Science.gov (United States)

The aim of the present study was to explore serum biomarkers for the pathology of IgA nephropathy using serum proteomics. The subjects were 57 patients with IgA nephropathy who were divided into two groups (group 1, n=25; group 2, n=32) and 14 healthy controls. Serum protein profiles were analyzed using the ProteinChip surface-enhanced laser desorption ionization (SELDI) system. Associations between signal intensities of proteins and histological findings in patients with IgA nephropathy were studied in group 1. Serum levels of a candidate biomarker protein (complement component C4a desArg) for IgA nephropathy were determined by enzyme linked-immunosorbent assay (ELISA) in group 2 and the relationships of these levels with histological findings were evaluated. There were significant differences in 93 protein signals between patients in group 1 and controls. Among these signals, 3 proteins at 8592, 8757 and 8806 m/z were significantly correlated with the severity of glomerular lesions. The protein at 8592 m/z was identified as C4a desArg and the signal intensity of 8592 m/z was strongly correlated with serum C4a levels, including C4a desArg, determined by ELISA. In addition, the serum levels of C4a (mainly C4a desArg) were significantly higher in patients in group 2 compared to controls and were correlated with the severity of glomerular lesions and with mesangial hypercellularity scores. In conclusion, the serum levels of complement C4a desArg are significantly higher in patients with IgA nephropathy compared to healthy controls and are significantly correlated with the severity of glomerular lesions and mesangial hypercellularity scores. Thus, serum C4a desArg is a potential biomarker for the severity of histological findings in patients with IgA nephropathy. PMID:23708385

Sogabe, Atsushi; Uto, Hirofumi; Kanmura, Shuji; Nosaki, Tsuyoshi; Oyamada, Miki; Tokunaga, Koki; Nishida, Chika; Fukumoto, Mayumi; Oku, Manei; Nishimoto, Kiichiro; Takenouchi, Shozo; Ido, Akio; Shimada, Yuko; Tsubouchi, Hirohito

2013-05-24

197

[Frailty criteria in the elderly: a pilot study].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To measure the frailty of people 75 years or over and who live in their own homes based on Fried's criteria and modified by Ávila-Funes. DESIGN: Pilot study of cross-sectional design. SITE: Primary Health Care Centres (7) in the city of Lleida. PARTICIPANTS: A probabilistic sample was selected for every stratum. The total sample was 323 individuals. PRIMARY MEASUREMENTS: Socio-demographic characteristics, measurement of the five frailty criteria (involuntary lose of weight, low energy or exhaustion, slow mobility, muscle weakness, low physical activity), and geriatric assessment scales (Charlson Index, Pfeiffer's Test, Katz Index, Lawton and Brody Index, MNA Test and CES-D scale). RESULTS: The prevalence of frailty was 8.5%. Factors associated with frailty were, female sex and low monthly income. It was observed that if the frailty increases, there is deterioration of cognitive status, activities of daily living and nutritional status. There is also higher morbidity. Frailty criteria scores showed a significant correlation with geriatric assessment scales scores. CONCLUSIONS: The prevalence of frailty in elderly people is similar to those in other studies that have used the same criteria. The measurement of frailty criteria in this study demonstrates a better ability for transcription of results. A frailty study using specific markers enhances prevention and improvement of new intervention programs.

Jürschik Giménez P; Escobar Bravo MÁ; Nuin Orrio C; Botigué Satorra T

2011-04-01

198

A detailed guide for quantification of myocardial scar with the Selvester QRS score in the presence of electrocardiogram confounders.  

UK PubMed Central (United Kingdom)

The Selvester QRS score translates subtle changes in ventricular depolarization measured by the electrocardiogram into information about myocardial scar location and size. This estimated scar has been shown to have a high degree of correlation with autopsy-measured myocardial infarct size. In addition, multiple studies have demonstrated the value of the QRS score in post-myocardial infarct patients to provide prognostic information. Recent studies have demonstrated that increasing QRS score is predictive of increased implantable defibrillator shocks for ventricular tachycardia and fibrillation as well as decreased response to cardiac resynchronization therapy. Although QRS scoring has never achieved widespread clinical use, increased interest in patient selection and risk-stratification techniques for implantable defibrillators and cardiac resynchronization therapy has led to renewed interest in QRS scoring and its potential to identify which patients will benefit from device therapy. The QRS score criteria were updated in 2009 to expand their use to a broader population by accounting for the different ventricular depolarization sequences in patients with bundle-branch/fascicular blocks or ventricular hypertrophy. However, these changes also introduced additional complexity and nuance to the scoring procedure. This article provides detailed instructions and examples on how to apply the QRS score criteria in the presence of confounding conduction types to facilitate understanding and enable development and application of automated QRS scoring.

Loring Z; Chelliah S; Selvester RH; Wagner G; Strauss DG

2011-09-01

199

Comparação entre alguns critérios de seleção para crescimento na raça Nelore Comparison between some selection criteria for growth traits correlated to scrotal circumference  

Directory of Open Access Journals (Sweden)

Full Text Available Utilizando 53.433 observações da raça Nelore, foram obtidas estimativas de parâmetros genéticos para pesos padronizados aos 120, 240 e 550 dias de idade (P120, P240 e P550), para número de dias para ganhar 160 kg até a desmama (D160), dias para ganhar mais 240 kg entre o desmame e o ponto final (D240) e perímetro escrotal aos 550 dias de idade (PE550). Adotou-se o método REML, sob modelo animal, e utilizaram-se modelos que incluíram como fixos os efeitos de grupo contemporâneo (constituído por fazenda, época do ano, sexo e regime alimentar) e classe de idade da vaca ao parto (120 meses) e, como aleatórios, os efeitos genéticos direto, materno e de ambiente permanente da vaca. As herdabilidades diretas (h a²), obtidas a partir das análises bi-caráter (PE550 com todas as outras), foram 0,19 para P120 e P240, 0,34 para P550, 0,09 para D160, 0,16 para D240 e média da h a² para PE550 foi de 0,36. As herdabilidades maternas variaram de 0,02 a 0,12 para as características de crescimento. As correlações foram todas de mediana magnitude. Os pesos padronizados constituem-se melhor critério de seleção, baseando-se nas estimativas de herdabilidade, do que o critério dias para atingir determinado peso. Entre as características utilizadas, o P550 apresenta a maior herdabilidade direta estimada e a melhor resposta correlacionada em PE550, indicando maior ganho genético, quando se considera a seleção direta para essa característica. Devido às baixas herdabilidades encontradas para as características D160 e D240, a adoção desse critério levaria à menor resposta à seleção do que para os pesos padronizados.Data to 53433 of Nellore cattle were used to estimate genetic parameters for standardized weights at 120, 240, and 550 days of age (P120, P240, and P550 respectively), scrotal circumference at 550 days (PE550), days to reach 160 kg (D160), and 240 kg (D240) of live weigh. It was used software the MTDFREML with mixed-model analysis using animal model. Model included fixed effects of contemporary groups (GC) and classes of age-of-dam calving and random direct and maternal genetic effects, the dam permanent environmental effect and the error. Direct heritability (h²a), in multiple-trait analysis between PE550 and all others traits, were .19 (for P120 and P240), .34 (for P550), .09 (for D160), .16 (for D240) and .36 (mean for PE550). Maternal heritability for growth traits ranged from .02 to .12. Genetic correlations among PE550 and the others traits had medium magnitude. Standardized weights rather than days to live weight, were better selection criteria when heritabilities and selection response were consideraded.

Analía del Valle Garnero; Raysildo Barbosa Lôbo; Luiz Antônio Framartino Bezerra; Henrique Nunes de Oliveira

2001-01-01

200

Comparação entre alguns critérios de seleção para crescimento na raça Nelore/ Comparison between some selection criteria for growth traits correlated to scrotal circumference  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Utilizando 53.433 observações da raça Nelore, foram obtidas estimativas de parâmetros genéticos para pesos padronizados aos 120, 240 e 550 dias de idade (P120, P240 e P550), para número de dias para ganhar 160 kg até a desmama (D160), dias para ganhar mais 240 kg entre o desmame e o ponto final (D240) e perímetro escrotal aos 550 dias de idade (PE550). Adotou-se o método REML, sob modelo animal, e utilizaram-se modelos que incluíram como fixos os efeitos de grup (more) o contemporâneo (constituído por fazenda, época do ano, sexo e regime alimentar) e classe de idade da vaca ao parto (120 meses) e, como aleatórios, os efeitos genéticos direto, materno e de ambiente permanente da vaca. As herdabilidades diretas (h a²), obtidas a partir das análises bi-caráter (PE550 com todas as outras), foram 0,19 para P120 e P240, 0,34 para P550, 0,09 para D160, 0,16 para D240 e média da h a² para PE550 foi de 0,36. As herdabilidades maternas variaram de 0,02 a 0,12 para as características de crescimento. As correlações foram todas de mediana magnitude. Os pesos padronizados constituem-se melhor critério de seleção, baseando-se nas estimativas de herdabilidade, do que o critério dias para atingir determinado peso. Entre as características utilizadas, o P550 apresenta a maior herdabilidade direta estimada e a melhor resposta correlacionada em PE550, indicando maior ganho genético, quando se considera a seleção direta para essa característica. Devido às baixas herdabilidades encontradas para as características D160 e D240, a adoção desse critério levaria à menor resposta à seleção do que para os pesos padronizados. Abstract in english Data to 53433 of Nellore cattle were used to estimate genetic parameters for standardized weights at 120, 240, and 550 days of age (P120, P240, and P550 respectively), scrotal circumference at 550 days (PE550), days to reach 160 kg (D160), and 240 kg (D240) of live weigh. It was used software the MTDFREML with mixed-model analysis using animal model. Model included fixed effects of contemporary groups (GC) and classes of age-of-dam calving and random direct and maternal g (more) enetic effects, the dam permanent environmental effect and the error. Direct heritability (h²a), in multiple-trait analysis between PE550 and all others traits, were .19 (for P120 and P240), .34 (for P550), .09 (for D160), .16 (for D240) and .36 (mean for PE550). Maternal heritability for growth traits ranged from .02 to .12. Genetic correlations among PE550 and the others traits had medium magnitude. Standardized weights rather than days to live weight, were better selection criteria when heritabilities and selection response were consideraded.

Garnero, Analía del Valle; Lôbo, Raysildo Barbosa; Bezerra, Luiz Antônio Framartino; Oliveira, Henrique Nunes de

2001-06-01

 
 
 
 
201

Agreement in Computer-Assisted Manual Scoring of Polysomnograms across Sleep Centers  

Science.gov (United States)

Study Objectives: To determine intersite agreement in respiratory event scoring of polysomnograms (PSGs) using different hypopnea definitions. Design: Technical assessment. Setting: Five academic medical centers. Participants: N/A. Interventions: N/A. Measurements and Results: Seventy good-quality PSGs performed in middle-aged women were manually scored by two experienced technologists at each of the five sleep centers using the particular laboratory's own software system. Studies were scored once by each scorer using American Academy of Sleep Medicine (AASM) standards for scoring sleep stages, arousals, and apneas. Hypopneas were then scored using three different AASM criteria: recommended, alternate, and research (Chicago). Means of each PSG variable for the scorers at each site were used to calculate an across-site intraclass correlation coefficient (ICC). Average AHI across the 10 scorers was 7.4 ± 12.3 (standard deviation) events/h using recommended criteria (ICC 0.984; 95% confidence interval [CI] 0.977-0.990), 12.1 ± 13.3 events/h using alternate criteria (ICC 0.947; 95% CI 0.889-0.972), and 15.1 ± 13.9 events/h with Chicago criteria (ICC 0.800; 95% CI 0.768-0.828). ICC across sites was 0.870 (95% CI = 0.847-0.889) for total sleep time, 0.861 (95% CI 0.837-0.881) for number of obstructive apneas and 0.683 (95% CI 0.640-0.722) for number of central apneas. ICCs across sites for hypopneas were very good using recommended criteria (ICC 0.843; 95% CI 0.820-0.870) but decreased when alternate criteria (ICC 0.728; 95% CI 0.689-0.763) and Chicago criteria (ICC 0.535; 95% CI 0.485-0.583) were used. Conclusion: Experienced scorers at different laboratories have very good agreement in hypopnea and AHI results when good-quality PSGs are scored using AASM-recommended criteria. Substantial degradation of reliability was observed for alternative definitions of hypopneas, particularly that proposed for research. Citation: Kuna ST; Benca R; Kushida CA; Walsh J; Younes M; Staley B; Hanlon A; Pack AI; Pien GW; Malhotra A. Agreement in computer-assisted manual scoring of polysomnograms across sleep centers. SLEEP 2013;36(4):583-589.

Kuna, Samuel T.; Benca, Ruth; Kushida, Clete A.; Walsh, James; Younes, Magdy; Staley, Bethany; Hanlon, Alexandra; Pack, Allan I.; Pien, Grace W.; Malhotra, Atul

2013-01-01

202

Contrasting Probabilistic Scoring Rules  

CERN Document Server

There are several scoring rules that one can choose from in order to score probabilistic forecasting models or estimate model parameters. Whilst it is generally agreed that proper scoring rules are preferable, there is no clear criterion for preferring one proper scoring rule above another. This manuscript compares and contrasts properties of some commonly used proper scoring rules and provides guidance on scoring rule selection. In particular, it is shown that the logarithmic scoring rule prefers erring on the side of caution, whereas the other scoring rules tend to be indifferent to the alternative risky option.

Machete, Reason Lesego

2011-01-01

203

Evaluating the South Oaks Gambling Screen With DSM-IV and DSM-5 Criteria: Results From a Diverse Community Sample of Gamblers.  

UK PubMed Central (United Kingdom)

Despite widespread use, the South Oaks Gambling Screen (SOGS) has been criticized for excessive false positives as an indicator of pathological gambling (PG), and for items that misalign with PG criteria. We examine the relationship between SOGS scores and PG symptoms and convergent validity with regard to personality, mood, and addictive behaviors in a sample of 353 gamblers. SOGS scores correlated r = .66 with both DSM-IV and DSM-5 symptoms, and they manifested similar correlations with external criteria (intraclass correlation of .95). However, 195 false positives and 1 false negative were observed when using the recommended cut point, yielding an 81% false alarm rate. For uses with DSM-IV criteria, a cut point of 10 would retain high sensitivity with greater specificity and fewer false positives. For DSM-5 criteria, we advocate a cut point of 8 for use as a clinical screen and a cut point of 12 for prevalence and pseudo-experimental studies.

Goodie AS; Mackillop J; Miller JD; Fortune EE; Maples J; Lance CE; Campbell WK

2013-08-01

204

A multivariate twin study of the DSM-IV criteria for antisocial personality disorder.  

UK PubMed Central (United Kingdom)

BACKGROUND: Many assessment instruments for psychopathy are multidimensional, suggesting that distinguishable factors are needed to effectively capture variation in this personality domain. However, no prior study has examined the factor structure of the DSM-IV criteria for antisocial personality disorder (ASPD). METHODS: Self-report questionnaire items reflecting all A criteria for DSM-IV ASPD were available from 4291 twins (including both members of 1647 pairs) from the Virginia Adult Study of Psychiatric and Substance Use Disorders. Exploratory factor analysis and twin model fitting were performed using, respectively, Mplus and Mx. RESULTS: Phenotypic factor analysis produced evidence for two correlated factors: aggressive-disregard and disinhibition. The best-fitting multivariate twin model included two genetic and one unique environmental common factor, along with criteria-specific genetic and environmental effects. The two genetic factors closely resembled the phenotypic factors and varied in their prediction of a range of relevant criterion variables. Scores on the genetic aggressive-disregard factor score were more strongly associated with risk for conduct disorder, early and heavy alcohol use, and low educational status, whereas scores on the genetic disinhibition factor score were more strongly associated with younger age, novelty seeking, and major depression. CONCLUSIONS: From a genetic perspective, the DSM-IV criteria for ASPD do not reflect a single dimension of liability but rather are influenced by two dimensions of genetic risk reflecting aggressive-disregard and disinhibition. The phenotypic structure of the ASPD criteria results largely from genetic and not from environmental influences.

Kendler KS; Aggen SH; Patrick CJ

2012-02-01

205

Is dimensional scoring important only for subthreshold levels of severity in personality disorders other than borderline?  

Science.gov (United States)

Research assessing the utility of dimensional and categorical models of personality disorders (PDs) overwhelmingly supports the use of continuous over categorical models. Using borderline PD as an example, recent studies from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project suggested that continuous (criteria count) scoring of PDs is most informative for "subthreshold" levels of pathology, but is less important once a patient meets the diagnostic threshold. Using PD criteria count, the current study compared 7 indices of psychosocial morbidity for patients above and below diagnostic threshold for 3 additional PDs: paranoid, avoidant, and obsessive-compulsive. Results showed that for all tested PDs, only number of current Axis I disorders was more correlated with PD criteria in the sub-threshold group as compared to those who met criteria for the disorder. Results for the remaining 6 indices of psychosocial morbidity varied by PD tested. PMID:23452906

Morgan, Theresa A; Chelminski, Iwona; Young, Diane; Dalrymple, Kristy; Zimmerman, Mark

2013-02-26

206

Is dimensional scoring important only for subthreshold levels of severity in personality disorders other than borderline?  

UK PubMed Central (United Kingdom)

Research assessing the utility of dimensional and categorical models of personality disorders (PDs) overwhelmingly supports the use of continuous over categorical models. Using borderline PD as an example, recent studies from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project suggested that continuous (criteria count) scoring of PDs is most informative for "subthreshold" levels of pathology, but is less important once a patient meets the diagnostic threshold. Using PD criteria count, the current study compared 7 indices of psychosocial morbidity for patients above and below diagnostic threshold for 3 additional PDs: paranoid, avoidant, and obsessive-compulsive. Results showed that for all tested PDs, only number of current Axis I disorders was more correlated with PD criteria in the sub-threshold group as compared to those who met criteria for the disorder. Results for the remaining 6 indices of psychosocial morbidity varied by PD tested.

Morgan TA; Chelminski I; Young D; Dalrymple K; Zimmerman M

2013-08-01

207

Judging criteria in international professional surfing championships.  

Directory of Open Access Journals (Sweden)

Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2012v14n4p439This study investigated the association between judges’ scores and the varia­bles that represent judging criteria of surfing events. A total of 164 waves ridden by 21 international surfers were recorded and analyzed in two stages of the Brazilian ASP World Tour (2007 and 2010). The following tests were used for descriptive analysis of data: the Kolmogorov-Smirnov and the Student t test, one-way ANOVA, the Tukey post-hoc test and Pearson correlation analysis (p?0.05). Significant differences were found between the scores of waves with bad, average and exceptional take-offs (p?0.05) and with controlled exit, fall in the main section of the wave (MSW) and after the MSW (p?0.001). There was a significant correlation (p?0.05) between wave scores and the following variables: frequency of imbalance in the maneuvers (r=-0.30), percentage of maneuvers in the critical section of the wave (r=0.68), variety of maneuvers (r=0.62), frequency of carving (r=0.51), re-entry (r=0.43), floater (r=0.23) and cut-back (r=0.27) maneuvers, length of ride (r=0.76) and total frequency of maneuvers (r=0.79) for the ASP World Tour 2007; percentage of maneuvers in the critical section of the wave (r=0.34), variety of maneuvers (r=0.70), frequency of carving (r=0.46), re-entry (r=0.51), cut-back (r=0.30) and aerial maneuvers (r=0.30), length of ride (r=0.71) and total frequency of maneuvers (r=0.75) for the ASP World Tour 2010. The results showed that all surfing criteria used by judges in this study correlated significantly with scores in the ASP World Tour 2007 and 2010, except for frequency of imbalances in the second competition.

Rosemeri Peirão; Saray Giovana dos Santos

2012-01-01

208

Validity and reliability of the SPORTS score.  

UK PubMed Central (United Kingdom)

PURPOSE: Successful outcomes for an athlete usually consist of returning to their sport. The Subjective Patient Outcome for Return to Sports (SPORTS) score has been recently proposed as an easy to use score for evaluating an athlete's ability to return to their sport. The aim of this study was to test the reliability and validity of the SPORTS score in athletes 5-10 years after anterior cruciate ligament reconstruction. METHODS: A total of 47 athletes (average age 30, range 15-45), 5-10 years, after an anterior cruciate reconstruction were included in this study. Athletes were asked to complete the SPORTS score with an intermediate period of 2 weeks in order to measure reliability by using the Bland-Altman method and the ICC score. The criterion validity was assessed by calculating the Spearman correlation coefficient between the SPORTS score and Lysholm score, KOOS score and the SF-36. RESULTS: The SPORTS score showed excellent reliability (ICC = 0.967). The systematic error was 0 points (95% upper limit of agreement = 1.8 points). A strong correlation was found between the SPORTS score and the sports and recreation component on the KOOS score (r = 0.55, P < 0.001). The floor effect was 9% and the ceiling effect 32%. CONCLUSION: This study suggests that the SPORTS score is a valid and reliable tool to assess and quantify return to sport.

Blonna D; Castoldi F; Delicio D; Bruzzone M; Dettoni F; Bonasia DE; Rossi R

2012-02-01

209

Does ScoliScore provide more information than traditional clinical estimates of curve progression?  

UK PubMed Central (United Kingdom)

STUDY DESIGN: Retrospective study comparing ScoliScore and clinical risk estimates. OBJECTIVE: The purpose of this study was to compare risk stratification between ScoliScore and traditional clinical estimates to determine whether ScoliScore provides unique information. SUMMARY OF BACKGROUND DATA: ScoliScore is a genetic prognostic test designed to evaluate the risk of curve progression in skeletally immature patients with adolescent idiopathic scoliosis with Cobb angles of 10° to 25°. Clinicians are currently trying to better understand the role this test may play in guiding clinical decision making because current standards of curve progression are largely based on radiographical markers, such as curve magnitude and bone age. METHODS: Ninety-one patients who received ScoliScore testing at our center and met study inclusion criteria were identified. Patients were given a "clinical risk" level using their Risser sign and Cobb angle. Assigned clinical risk levels were compared with the ScoliScore risk levels reported by the manufacturer's scoring algorithm. RESULTS: ScoliScore risk distribution in our population was 36% low risk, 55% intermediate risk, and 9% high risk. This compares with 2%, 51%, and 47%, respectively, for comparable clinical risk groupings. Only 25% of patients were in the same risk category for both systems. There were no significant correlations between ScoliScore and age, race, menarcheal status, Risser sign, or sex. There was a positive correlation between the Cobb angle and the ScoliScore (r = 0.581, P < 0.001). Cobb angle remained significant in the multivariate regression model (P < 0.001), and Cobb angle was found to account for 33.3% of ScoliScore's variance. CONCLUSION: Only Cobb angle showed significant correlation with ScoliScore among the socioclinical variables studied. The risk distribution of the 2 risk estimation systems examined differed markedly: ScoliScore predicted nearly 16 times more low-risk patients and more than 5 times fewer high-risk patients. This demonstrates that ScoliScore provides unique information to traditional predictors of curve progression, advancing our understanding of the role of ScoliScore in the clinical setting.

Roye BD; Wright ML; Williams BA; Matsumoto H; Corona J; Hyman JE; Roye DP Jr; Vitale MG

2012-12-01

210

Score regularization for peptide identification  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Peptide identification from tandem mass spectrometry (MS/MS) data is one of the most important problems in computational proteomics. This technique relies heavily on the accurate assessment of the quality of peptide-spectrum matches (PSMs). However, current MS technology and PSM scoring algorithm are far from perfect, leading to the generation of incorrect peptide-spectrum pairs. Thus, it is critical to develop new post-processing techniques that can distinguish true identifications from false identifications effectively. Results In this paper, we present a consistency-based PSM re-ranking method to improve the initial identification results. This method uses one additional assumption that two peptides belonging to the same protein should be correlated to each other. We formulate an optimization problem that embraces two objectives through regularization: the smoothing consistency among scores of correlated peptides and the fitting consistency between new scores and initial scores. This optimization problem can be solved analytically. The experimental study on several real MS/MS data sets shows that this re-ranking method improves the identification performance. Conclusions The score regularization method can be used as a general post-processing step for improving peptide identifications. Source codes and data sets are available at: http://bioinformatics.ust.hk/SRPI.rar.

He Zengyou; Zhao Hongyu; Yu Weichuan

2011-01-01

211

Assessment of lung disease in children with cystic fibrosis using hyperpolarized 3-Helium MRI: comparison with Shwachman score, Chrispin-Norman score and spirometry  

Energy Technology Data Exchange (ETDEWEB)

This study assesses the feasibility of hyperpolarized 3-Helium MRI in children with cystic fibrosis (CF) and correlates the findings with standard clinical parameters based on chest radiograph (CXR) and pulmonary function tests (PFT). An uncontrolled, observational study in eighteen children with cystic fibrosis aged 5 - 17 years (median 12.1 years), with different severity of disease was carried out. All subjects underwent routine clinical assessment including PFT and standard auxology; CXR was obtained and Shwachman and Chrispin-Norman scores calculated. Hyperpolarized 3-He magnetic resonance imaging (MRI) was carried out using a spin-exchange polarizer and a whole body 1.5 T scanner. Ventilation distribution images were obtained during a 21-second breath-hold and scored according to previously defined criteria. Spearman's non-parametric correlations test was performed to assess for statistical significance at the p<0.05 level. The children tolerated the procedure well. No desaturation events were observed during 3-He MRI. A significant, albeit moderate, correlation was found between MRI score and FEV1% predicted (r=-0.41; p=0.047) and FVC% predicted (r=-0.42; p=0.04), while there were trends of correlations between Shwachman score and MRI score (r=-0.38; p=0.06) and Shwachman score and FEV1% predicted (r=0.39; p=0.055). The feasibility of hyperpolarized 3-He MRI in children with CF was demonstrated. MRI appears to be able to demonstrate functional lung changes, although correlations with routine clinical tests are only moderate to poor. This non-ionising radiation technique could be useful for monitoring lung disease and assessing therapy in this patient population. (orig.)

Beek, Edwin J.R. van [University of Sheffield, Unit of Academic Radiology, Sheffield (United Kingdom); University of Iowa, Department of Radiology, Carver College of Medicine, Iowa City (United States); University of Iowa, Department of Radiology, Iowa City, IA (United States); Hill, Catherine; Woodhouse, Neil; Fichele, Stanislao; Fleming, Sally; Wild, Jim M. [University of Sheffield, Unit of Academic Radiology, Sheffield (United Kingdom); Howe, Bridget; Bott, Sandra; Taylor, Christopher J. [University of Sheffield, Academic Unit of Child Health, Sheffield (United Kingdom)

2007-04-15

212

Diagnostic criteria in rheumatoid arthritis.  

UK PubMed Central (United Kingdom)

For rheumatoid arthritis (RA), criteria have been developed for classification of groups of patients in population surveys, selection for therapeutic trials, inter-institutional comparison of patients, evaluation of diagnostic trials, diagnosis of RA in individual patients, estimation of disease frequency, and assistance in determining prognosis. The American Rheumatism Association (ARA) "Criteria for the Classification of Rheumatoid Arthritis-Diagnostic Criteria for Rheumatoid Arthritis" were published in 1958 and have become a standard. These criteria are empiric and attempt to incorporate reasonable combinations of sensitivity and specificity. Despite the recognition that these criteria should be expected to change with improved knowledge, no further modification has been published. Other criteria such as the ARA "Proposed Criteria for Rheumatoid Arthritis" represent an important effort to encourage uniformity in definitions and use of the term remission. Yet it is well to remember that they have never been tested in prospective studies and are considered preliminary. The Co-operative Systematic Studies in Rheumatic Diseases, when studying slow-acting anti-rheumatic drugs, have chosen to use clinical endpoints such as 50% improvement in joint tenderness and swelling counts (or scores) rather than combined variables which include morning stiffness and changes in laboratory variables. This approach permits the true assessment of drug effects. In summary, current criteria have served us well. Nonetheless, we should not become complacent and should always question their sensitivity, specificity and application.

Clegg DO; Ward JR

1987-01-01

213

Interpreting force concept inventory scores: Normalized gain and SAT scores  

Science.gov (United States)

Preinstruction SAT scores and normalized gains (G) on the force concept inventory (FCI) were examined for individual students in interactive engagement (IE) courses in introductory mechanics at one high school (N=335) and one university (N=292) , and strong, positive correlations were found for both populations ( r=0.57 and r=0.46 , respectively). These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawsonâs Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of studentsâ cognitive skills, as measured either by the SAT or by Lawsonâs test. While Lawsonâs test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of studentsâ reasoning abilities. Knowing the studentsâ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve studentsâ cognitive level.

Coletta, Vincent P.; Phillips, Jeffery; Steinert, Jeffery J.

2008-09-03

214

Extension of the lod score: the mod score.  

UK PubMed Central (United Kingdom)

In 1955 Morton proposed the lod score method both for testing linkage between loci and for estimating the recombination fraction between them. If a disease is controlled by a gene at one of these loci, the lod score computation requires the prior specification of an underlying model that assigns the probabilities of genotypes from the observed phenotypes. To address the case of linkage studies for diseases with unknown mode of inheritance, we suggested (Clerget-Darpoux et al., 1986) extending the lod score function to a so-called mod score function. In this function, the variables are both the recombination fraction and the disease model parameters. Maximizing the mod score function over all these parameters amounts to maximizing the probability of marker data conditional on the disease status. Under the absence of linkage, the mod score conforms to a chi-square distribution, with extra degrees of freedom in comparison to the lod score function (MacLean et al., 1993). The mod score is asymptotically maximum for the true disease model (Clerget-Darpoux and Bonaïti-Pellié, 1992; Hodge and Elston, 1994). Consequently, the power to detect linkage through mod score will be highest when the space of models where the maximization is performed includes the true model. On the other hand, one must avoid overparametrization of the model space. For example, when the approach is applied to affected sibpairs, only two constrained disease model parameters should be used (Knapp et al., 1994) for the mod score maximization. It is also important to emphasize the existence of a strong correlation between the disease gene location and the disease model. Consequently, there is poor resolution of the location of the susceptibility locus when the disease model at this locus is unknown. Of course, this is true regardless of the statistics used. The mod score may also be applied in a candidate gene strategy to model the potential effect of this gene in the disease. Since, however, it ignores the information provided both by disease segregation and by linkage disequilibrium between the marker alleles and the functional disease alleles, its power of discrimination between genetic models is weak. The MASC method (Clerget-Darpoux et al., 1988) has been designed to address more efficiently the objectives of a candidate gene approach.

Clerget-Darpoux F

2001-01-01

215

Endoscopic scoring system for extraparenchymal neurocysticercosis.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To propose a scoring system using endoscopy for assessment of the inflammatory alterations caused by neurocysticercosis (NCC) inside the ventricular cavities and the basal subarachnoid space. METHODS: Video recordings of the endoscopic procedures in patients with hydrocephalus secondary to NCC were assessed in a two-phase study. In the first phase (n = 10), the assigned score of each patient was correlated with the cerebrospinal fluid values obtained by lumbar and ventricular puncture. Reproducibility was determined using an intraclass correlation coefficient. In the second phase (n = 30), the prognostic value of the score was tested by comparing it with the patient's Karnofsky performance score (KPS) 3 months after endoscopy. RESULTS: The score included four main components: ependymal findings, number of involved sites, abnormalities in the subarachnoid space, and other alterations. These values were summed to produce a total score, which correlated strongly with both protein and cell counts from ventricular cerebrospinal fluid. The intraclass correlation coefficient of the global score was 0.85. In the second phase, the scores were divided into mild, moderate, and severe categories (6, 15, and 9 patients). The initial KPS was similar between the groups (P = 0.56); however, when measured 3 months later, there were significant differences (P = 0.02). The logistic regression analysis of patients with a score in the severe range (odds ratio = 0.09; 95% confidence interval, 0.06-0.64) showed a reduced chance for achieving a good outcome (KPS ?90) after 3 months. CONCLUSIONS: Our scoring system enables endoscopic classification of the damage caused by NCC in the ventricular and basal subarachnoid space. The score has a biologic basis and a good internal reproducibility. The score seems to be useful for determining the short-term prognosis, and patients with high scores require additional therapeutic measures to improve their outcomes.

Tapia-Pérez JH; Torres-Corzo JG; Chalita-Williams JC; Rodríguez-Della Vecchia R; Sánchez-Rodríguez JJ; Sánchez-Aguilar M

2013-02-01

216

Scoring systems in high risk pregnancy.  

Science.gov (United States)

Antenatal care serves the purpose of screening malformations and detecting treatable medical conditions as well as identifying high risk pregnancies (HRP). HRP scoring systems require reliable statistics, well-defined objectives, the definition of high risk conditions, and the recognition of the capabilities of these systems. Primary care doctors can take advantage of the modified Al-Zahraa University (Z.U.H.) high risk score for prenatal risk assessing cardiovascular, renal, and metabolic history as well as anatomic abnormalities; the modified Bishop scoring system for assessment of the state of the uterine cervix (1964); the Zatuchni-Andros criteria for scoring of breech delivery (1967); the fetal heart rate tracing score as modified later Kaar to predict feto-placental functions (1980); and the biophysical profile scoring technique. Secondary and tertiary care doctors are recommended to use scores relating to maternal factors, placental factors, and fetal factors in addition to the modified Z.U.H. high risk score. The Apgar score is used for the assessment of the newborn after delivery. These scoring systems are not perfect, as false positives and false negatives do occur that could be minimized by finer screening using clinical tests. PMID:12317329

Fatouh, A A; Fakhr, M M

1991-01-01

217

Analysis of Project Success Criteria in the Nigerian Construction Industry  

Directory of Open Access Journals (Sweden)

Full Text Available This paper examined the relative importance of the project success criteria in the Nigerian construction industry. It also determined the correlation among the project success criteria. Based on the literatures reviewed, the study proposed a framework for measuring project success in the construction industry. The respondents for the study were the government, private clients, consultants and contractors. Three hundred copies of questionnaires were distributed to capture data on the subject, but only 86 were returned and used for the study. The paper captured respondents that are resident in Lagos state, Nigeria and chosen by convenience from selected organizations used for the study. The data were analysed with SPSS 16 through the use of frequencies, mean scores, factor analysis and correlation. Factor analysis was employed because the mean scores showed that all the project success criteria were at least important. Nine principal components were finally merged into 4 through the factor analysis using the Varimax rotation with Keiser normalization. The study found out that all the project success criteria were important but their level of importance differs according to the factor analysis carried out. Therefore, it was concluded that there are four major components of construction project success in Nigeria- user-related factors, professionals’ factors, organisational factors and other minor factors. The minor factors were found to be related to both organizations and projects but were not highly rated by respondents for determining construction project success. The study also concludes that project success criteria goes beyond meeting cost, time and quality target, it includes users’ satisfaction, professionals’ fulfilment and achievement of organizational goals. The recommendation of the study was that for construction projects to be successful, attention must be paid to users’ related factors, professionals’ factors and organizations’ factors.

Oluwaseun Sunday Dosumu; Henry Ndubuisi Onukwube

2013-01-01

218

7 CFR 1703.126 - Criteria for scoring grant applications.  

Science.gov (United States)

...system (up to 35 points); (7) Project participation in EZ/ECs (Empowerment Zone and Enterprise Communities) and Champion...costs of such facilities. (7) Project participation in EZ/ECs and champion communitiesâ(Up to 15 Points). This...

2009-01-01

219

Initial experience with identifying high-grade prostate cancer using diffusion-weighted MR imaging (DWI) in patients with a Gleason score ? 3 + 3 = 6 upon schematic TRUS-guided biopsy: a radical prostatectomy correlated series.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Diffusion-weighted magnetic resonance (MR) imaging (DWI) might be able to fulfill the need to accurately identify high-grade prostate carcinoma, in patients initially selected for active surveillance in the Prostate Specific Antigen (PSA) screening era based on transrectal ultrasound-guided biopsy Gleason score. We aimed to determine whether DWI is able to correctly identify those patients with a biopsy Gleason score of ? 3 + 3 = 6, but harboring Gleason 4 and/or 5 components in their radical prostatectomy (RP) specimen. MATERIALS AND METHODS: Whole-mount RP specimens were used to identify regions of interest corresponding with tumor on the DWI-derived apparent diffusion coefficient (ADC) maps in 23 patients with a Gleason ? 3 + 3 = 6 on biopsy. ADC values were correlated with RP Gleason grades. Statistical analysis was performed by calculating area under the receiver operating characteristic curve for identification of prostate cancer with Gleason 4 and/or 5 components using DWI, and Mann-Whitney U testing was performed to detect differences in median ADC values for tumors with presence of Gleason grade 4 and/or 5 versus a highest Gleason grade of ? 3 on RP. RESULTS: A diagnostic accuracy of median ADC values for identifying patients subject to transrectal ultrasound-guided biopsy undergrading with an area under the receiver operating characteristic curve of 0.88 was established using RP Gleason score as a reference. In patients harboring a Gleason 4 and/or 5 component, the median ADC was 0.86 × 10(-3) mm/s (standard deviation ± 0.21), whereas patients harboring no Gleason 4 and/or 5 component displayed a median ADC of 1.16 × 10(-3) mm/s (standard deviation ± 0.19) for the single tumor slice with the lowest median ADC (P < 0.002). CONCLUSIONS: DWI is able to predict the presence of high-grade tumor in patients with a Gleason ? 3 + 3 = 6 on biopsy, providing important information for treatment decisions.

Somford DM; Hambrock T; Hulsbergen-van de Kaa CA; Fütterer JJ; van Oort IM; van Basten JP; Karthaus HF; Witjes JA; Barentsz JO

2012-03-01

220

Correlações genéticas de características de tamanho corporal e condição corporal com características de eficiência produtiva de fêmeas da raça Canchim/ Genetic correlations among cow body size, condition score and productive traits in Canchim cows  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Os objetivos neste trabalho foram estimar a herdabilidade do número (NBZ10 e NBZT) e quilogramas de bezerros desmamados (QBD10 e QBDT) pela vaca até dez anos de idade e durante a permanência da fêmea no rebanho e de quilogramas de bezerros desmamados pela vaca por ano de permanência no rebanho (QTPR) e as correlações genéticas dessas características com os pesos ajustados e não-ajustados para condição corporal, índice de tamanho corporal e condições corpora (more) is à primeira monta, ao primeiro parto e à idade adulta, idades ao primeiro, segundo e terceiro partos e tempo de permanência no rebanho. Os componentes de variância e de co-variância foram estimados pelo método da máxima verossimilhança restrita livre de derivadas, usando-se análises uni e bicaracterísticas. Os modelos estatísticos incluíram o efeito genético aditivo direto, como aleatório, e o efeito fixo de grupo de contemporâneos. As estimativas de herdabilidade obtidas das análises unicaracterísticas foram 0,10 ± 0,05 (NBZT), 0,10 ± 0,03 (QBDT), 0,12 ± 0,05 (NBZ10), 0,13 ± 0,05 (QBD10) e 0,15 ± 0,05 (QTPR), indicando que baixa resposta à seleção será obtida para essas características. A seleção para redução na idade ao primeiro parto não incrementará a produtividade das vacas. A seleção para aumentar o peso adulto das fêmeas acarretará redução em QTPR, NBZ10 e NBZT. A seleção para os índices de tamanho corporal ou para os pesos ajustados para condição corporal deve apresentar respostas correlacionadas com as características produtivas das fêmeas com tendências semelhantes, mas de maior magnitude que a seleção para peso da fêmea sem ajuste. Abstract in english The objectives of this study were to obtain heritability estimates for number (NBZ10 and NBZT) and kilograms (QBD10 and QBDT) of calves weaned up to ten years of age and during herd life, kilograms of calves weaned per year in herd (QTPR) and their genetic correlations with culling age, ages at first, at second and at third calving, adjusted and unadjusted weights for condition score, body size indexes and condition score at first mating, at first calving and at mature ag (more) e. Variance and covariance components were estimated by REML using univariate and bivariate models including the fixed effect of contemporary group and additive direct genetic and residual as random effects. Heritability estimates obtained from univariate analyses were 0.10 ± 0.05 (NBZT), 0.10 ± 0.03 (QBDT), 0.12 ± 0.05 (NBZ10), 0.13 ± 0.05 (QBD10) and 0.15 ± 0.05 (QTPR) and indicate low response by selection on these traits. Genetic correlation estimate suggest that selection for reducing age at first calving will not improve cow productivity. Selection for increasing mature weight will reduce kilograms of calves weaned per year in herd and the number of calves weaned up to ten years of age and during herd life. Selection on body size indexes and on cow weights adjusted for condition score may result in similar correlated responses in productive traits of cows, which would be higher than those from selection on unadjusted cow weights.

Baldi, Fernando; Alencar, Mauricio Mello de; Freitas, Alfredo Ribeiro de

2008-03-01

 
 
 
 
221

Assessment of lung disease in children with cystic fibrosis using hyperpolarized 3-Helium MRI: comparison with Shwachman score, Chrispin-Norman score and spirometry  

International Nuclear Information System (INIS)

This study assesses the feasibility of hyperpolarized 3-Helium MRI in children with cystic fibrosis (CF) and correlates the findings with standard clinical parameters based on chest radiograph (CXR) and pulmonary function tests (PFT). An uncontrolled, observational study in eighteen children with cystic fibrosis aged 5 - 17 years (median 12.1 years), with different severity of disease was carried out. All subjects underwent routine clinical assessment including PFT and standard auxology; CXR was obtained and Shwachman and Chrispin-Norman scores calculated. Hyperpolarized 3-He magnetic resonance imaging (MRI) was carried out using a spin-exchange polarizer and a whole body 1.5 T scanner. Ventilation distribution images were obtained during a 21-second breath-hold and scored according to previously defined criteria. Spearman's non-parametric correlations test was performed to assess for statistical significance at the p

2007-01-01

222

Various criteria in the evaluation of biomedical named entity recognition.  

UK PubMed Central (United Kingdom)

BACKGROUND: Text mining in the biomedical domain is receiving increasing attention. A key component of this process is named entity recognition (NER). Generally speaking, two annotated corpora, GENIA and GENETAG, are most frequently used for training and testing biomedical named entity recognition (Bio-NER) systems. JNLPBA and BioCreAtIvE are two major Bio-NER tasks using these corpora. Both tasks take different approaches to corpus annotation and use different matching criteria to evaluate system performance. This paper details these differences and describes alternative criteria. We then examine the impact of different criteria and annotation schemes on system performance by retesting systems participated in the above two tasks. RESULTS: To analyze the difference between JNLPBA's and BioCreAtIvE's evaluation, we conduct Experiment 1 to evaluate the top four JNLPBA systems using BioCreAtIvE's classification scheme. We then compare them with the top four BioCreAtIvE systems. Among them, three systems participated in both tasks, and each has an F-score lower on JNLPBA than on BioCreAtIvE. In Experiment 2, we apply hypothesis testing and correlation coefficient to find alternatives to BioCreAtIvE's evaluation scheme. It shows that right-match and left-match criteria have no significant difference with BioCreAtIvE. In Experiment 3, we propose a customized relaxed-match criterion that uses right match and merges JNLPBA's five NE classes into two, which achieves an F-score of 81.5%. In Experiment 4, we evaluate a range of five matching criteria from loose to strict on the top JNLPBA system and examine the percentage of false negatives. Our experiment gives the relative change in precision, recall and F-score as matching criteria are relaxed. CONCLUSION: In many applications, biomedical NEs could have several acceptable tags, which might just differ in their left or right boundaries. However, most corpora annotate only one of them. In our experiment, we found that right match and left match can be appropriate alternatives to JNLPBA and BioCreAtIvE's matching criteria. In addition, our relaxed-match criterion demonstrates that users can define their own relaxed criteria that correspond more realistically to their application requirements.

Tsai RT; Wu SH; Chou WC; Lin YC; He D; Hsiang J; Sung TY; Hsu WL

2006-01-01

223

Fratura na coluna vertebral por mieloma múltiplo: correlação entre sobrevida e índices de Tomita e Tokuhashi/ Multiple myeloma and vertebral fractures: correlation between survival rate and Tomita and Tokuhashi scores/ Fractura de la columna vertebral por mieloma múltiple: correlación entre sobrevida e índices de Tomita y Tokuhashi  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVO: o mieloma múltiplo (MM) é a neoplasia óssea primária mais freqüente na coluna vertebral. Em razão da grande morbi-mortalidade destas lesões, discute-se qual o melhor tratamento nestes pacientes. Na prática, observamos similaridade das opções de tratamento entre os pacientes portadores de metástases ósseas e MM. Os índices de sobrevida de Tomita e Tokuhashi são utilizados com o intuito de auxiliar na escolha do tratamento nos portadores de metástas (more) es. Faltam estudos sobre a aplicabilidade destes índices em pacientes portadores de MM. Neste trabalho vamos avaliar a aplicabilidade dos índices de Tomita e Tokuhashi nos pacientes portadores de MM e lesão vertebral. MÉTODOS: estudo retrospectivo mediante avaliação de prontuários e radiografias de portadores de MM por meio da aplicação dos critérios de Tomita e Tokuhashi. RESULTADOS: em um ano, 19 (63,3%) estavam vivos, em dois anos 13 (43,3%) e em cinco anos quatro (13,3%) pacientes estavam vivos. Não houve correlação entre os índices (Tomita e Tokuhashi) e a taxa de sobrevida nestes pacientes (p= 0,2255). CONCLUSÃO: há necessidade de adaptação dos índices de Tomita e Tokuhashi para apresentarem aplicabilidade nos portadores de MM na coluna. Abstract in spanish OBJETIVO: el Mieloma Múltiple (MM) es la neoplasia ósea primaria más frecuente en la columna vertebral. En razón de la gran morbimortalidad de estas lesiones, se discute cuál sería el mejor tratamiento en estos pacientes. En la práctica observamos semejanza de las opciones de tratamiento entre los pacientes portadores de metástasis óseas y MM. Los índices de sobrevida de Tomita y Tokuhashi son utilizados con el objetivo de auxiliar en la opción del tratamiento (more) en los portadores de metástasis. Faltan estudios sobre la aplicabilidad de estos índices en pacientes portadores de MM. En este trabajo vamos a evaluar la aplicabilidad de los índices de Tomita y Tokuhashi en los pacientes portadores de MM y lesión vertebral. MÉTODOS: estudio retrospectivo mediante evaluación de historias clínicas y radiografías de portadores de MM por medio de la aplicación de los criterios de Tomita y Tokuhashi. RESULTADOS: En un año 19 estuvieron vivos (63.3%), en 2 años fueron 13 (43.3%) y en 5 años fueron 4 los que estuvieron vivos (13.3%). No hubo correlación entre los índices (Tomita y Tokuhashi) y la tasa de sobrevida en estos pacientes (p= 0.2255). CONCLUSIÓN: Hay necesidad de adaptación de los índices de Tomita y Tokuhashi para presentar una aplicabilidad en los portadores de MM en la columna. Abstract in english OBJECTIVE: multiple myeloma (MM) is the most common primary neoplasm tumor in the spine. Due to the high morbidity and mortality of these spinal lesions, it is of important to discuss the best treatment in these patients. In clinical practice, there are similarities in the treatment options for patients with bone metastasis and MM. The survival rates of Tomita and Tokuhashi scores are used in order to assist in the choice of treatment patients with metastasis. No studies (more) about the applicability of these scores in patients with MM were found. The objective of this study is to evaluate the applicability of Tomita and Tokuhashi scores in patients with MM and vertebral lesions. METHODS: Retrospective study on evaluation of radiographs and medical records of patients with MM using the criteria of Tomita and Tokuhashi. RESULTS: At 1 year 19 (63.3%) were alive, 2 years 13 (43.3%) and 5 years 4 (13.3%) patients were alive. There was no correlation between the scores (Tomita and Tokuhashi) and survival rate in these patients (p = 0.2255). CONCLUSION: There is a need for adjustment or alterations of the scores of Tomita and Tokuhashi to have applicability in patients with MM in column.

Avanzi, Osmar; Landim, Elcio; Meves, Robert; Caffaro, Maria Fernanda Silber; Lima, Marcos Vaz de

2009-03-01

224

Determining ICH Score: can we go beyond?  

UK PubMed Central (United Kingdom)

Spontaneous intracerebral hemorrhage (SICH) still presents a great heterogeneity in its clinical evaluation, demonstrating differences in the enrollment criteria used for the study of intracerebral hemorrhage (ICH) treatment. The aim of the current study was to assess the ICH Score, a simple and reliable scale, determining the 30-day mortality and the one-year functional outcome. Consecutive patients admitted with acute SICH were prospectively included in the study. ICH Scores ranged from 0 to 4, and each increase in the ICH Score was associated with an increase in the 30-day mortality and with a progressive decrease in good functional outcome rates. However, the occurrence of a pyramidal pathway injury was better related to worse functional outcome than the ICH Score. The ICH Score is a good predictor of 30-day mortality and functional outcome, confirming its validity in a different socioeconomic populations. The association of the pyramidal pathway injury as an auxiliary variable provides more accurate information about the prognostic evolution.

Patriota GC; Silva-Júnior JM; Barcellos AC; Silva Júnior JB; Toledo DO; Pinto FC; Rotta JM

2009-09-01

225

Prostate cancer antigen 3 score accurately predicts tumour volume and might help in selecting prostate cancer patients for active surveillance.  

UK PubMed Central (United Kingdom)

BACKGROUND: The optimal selection of prostate cancer (PCa) patients for active surveillance (AS) is currently being debated. OBJECTIVE: To assess the impact of urinary prostate cancer antigen 3 (PCA3) score as an AS criterion instead of and in addition to the current criteria. DESIGN, SETTING, AND PARTICIPANTS: We prospectively studied 106 consecutive low-risk PCa patients (prostate-specific antigen [PSA] ?10 ng/ml, clinical stage T1c-T2a, and biopsy Gleason score 6) who underwent a PCA3 urine test before radical prostatectomy (RP). MEASUREMENTS: Performance of AS criteria (biopsy criteria, PCA3 score, PSA density, and magnetic resonance imaging [MRI] findings) was tested in predicting four prognostic pathologic findings in RP specimens: (1) pT3-4 disease; (2) overall unfavourable disease (OUD) defined by pT3-4 disease and/or pathologic primary Gleason pattern 4; (3) tumour volume <0.5 cm(3); and (4) insignificant PCa. RESULTS AND LIMITATIONS: The PCA3 score was strongly correlated with the tumour volume in a linear regression analysis (p<0.001, r=0.409). The risk of having a cancer ?0.5 cm(3) and a significant PCa was increased three-fold in men with a PCA3 score of ?25 compared with men with a PCA3 score of <25 with most AS biopsy criteria used. There was a trend towards higher PCA3 scores in patients with unfavourable and non-organ-confined disease and Gleason >6 cancers. In a multivariate analysis taking into account each AS criterion, a high PCA3 score (?25) was an important predictive factor for tumour volume ?0.5 cm(3) (odds ratio [OR]: 5.4; p=0.010) and significant PCa (OR: 12.7; p=0.003). Biopsy criteria and MRI findings were significantly associated with OUD (OR: 3.9 and 5.0, respectively; p=0.030 and p=0.025, respectively). CONCLUSIONS: PCA3 score may be a useful marker to improve the selection for AS in addition to the current AS criteria. With a predictive cut-off of 25, PCA3 score is strongly indicative for tumour volume and insignificant PCa.

Ploussard G; Durand X; Xylinas E; Moutereau S; Radulescu C; Forgue A; Nicolaiew N; Terry S; Allory Y; Loric S; Salomon L; Vacherot F; de la Taille A

2011-03-01

226

Is dimensional scoring of borderline personality disorder important only for subthreshold levels of severity?  

Science.gov (United States)

Studies comparing dimensional and categorical representations of personality disorders (PDs) have consistently found that PD dimensions are more reliable and valid. While comparisons of dimensional and categorical scoring approaches have consistently favored the dimension model, two reports from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project have raised questions as to when dimensional scoring is important. In the first study, Asnaani, Chelminski, Young, and Zimmerman (2007) found that once the diagnostic threshold for borderline PD was reached the number of criteria met was not significantly associated with indices of psychosocial morbidity. In the second study, Zimmerman, Chelminski, Young, Dalrymple, and Martinez (2012) found that patients with 1 criterion of borderline PD had significantly more psychosocial morbidity than patients with 0 criteria. The findings of these two studies suggest that dimensional ratings of borderline PD may be more strongly associated with indicators of illness severity for patients who do not versus do meet the DSM-IV criteria for borderline PD. In this third report from the MIDAS project, we tested this hypothesis in a study of 3,069 psychiatric outpatients evaluated with semi-structured diagnostic interviews. In the patients without borderline PD the number of borderline features was significantly associated with each of 6 indicators of illness severity, whereas in the patients with borderline PD 3 of the 6 correlations were significant. The mean correlation between the number of borderline PD criteria and the indicators of illness severity was nearly three times higher in the patients without borderline PD than the patients with borderline PD (0.23 versus 0.08), and 4 of the 6 correlation coefficients were significantly higher in the patients without borderline PD. These findings suggest that dimensional scoring of borderline PD is more important for subthreshold levels of pathology and are less critical once a patient meets the diagnostic threshold. The implications of these findings for DSM-5 are discussed. PMID:23514187

Zimmerman, Mark; Chelminski, Iwona; Young, Diane; Dalrymple, Kristy; Martinez, Jennifer

2013-04-01

227

Is dimensional scoring of borderline personality disorder important only for subthreshold levels of severity?  

UK PubMed Central (United Kingdom)

Studies comparing dimensional and categorical representations of personality disorders (PDs) have consistently found that PD dimensions are more reliable and valid. While comparisons of dimensional and categorical scoring approaches have consistently favored the dimension model, two reports from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project have raised questions as to when dimensional scoring is important. In the first study, Asnaani, Chelminski, Young, and Zimmerman (2007) found that once the diagnostic threshold for borderline PD was reached the number of criteria met was not significantly associated with indices of psychosocial morbidity. In the second study, Zimmerman, Chelminski, Young, Dalrymple, and Martinez (2012) found that patients with 1 criterion of borderline PD had significantly more psychosocial morbidity than patients with 0 criteria. The findings of these two studies suggest that dimensional ratings of borderline PD may be more strongly associated with indicators of illness severity for patients who do not versus do meet the DSM-IV criteria for borderline PD. In this third report from the MIDAS project, we tested this hypothesis in a study of 3,069 psychiatric outpatients evaluated with semi-structured diagnostic interviews. In the patients without borderline PD the number of borderline features was significantly associated with each of 6 indicators of illness severity, whereas in the patients with borderline PD 3 of the 6 correlations were significant. The mean correlation between the number of borderline PD criteria and the indicators of illness severity was nearly three times higher in the patients without borderline PD than the patients with borderline PD (0.23 versus 0.08), and 4 of the 6 correlation coefficients were significantly higher in the patients without borderline PD. These findings suggest that dimensional scoring of borderline PD is more important for subthreshold levels of pathology and are less critical once a patient meets the diagnostic threshold. The implications of these findings for DSM-5 are discussed.

Zimmerman M; Chelminski I; Young D; Dalrymple K; Martinez J

2013-04-01

228

A comparative study of conservation and variation scores  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Conservation and variation scores are used when evaluating sites in a multiple sequence alignment, in order to identify residues critical for structure or function. A variety of scores are available today but it is not clear how different scores relate to each other. Results We applied 25 conservation and variation scores to alignments from the Catalytic Site Atlas (CSA). We calculated distances among scores based on correlation coefficients, and constructed a dendrogram of the scores by average linking cluster analysis. The cluster analysis showed that most scores fall into one of two groups--substitution matrix based group and frequency based group respectively. We also evaluated the scores' performance in predicting catalytic sites and found that frequency based scores generally perform best. Conclusions Conservation and variation scores can be classified into mainly two large groups. When using a score to predict catalytic sites, frequency based scores that also consider a background distribution are most successful.

Johansson Fredrik; Toh Hiroyuki

2010-01-01

229

Interpreting force concept inventory scores: Normalized gain and SAT scores  

Directory of Open Access Journals (Sweden)

Full Text Available Preinstruction SAT scores and normalized gains (G) on the force concept inventory (FCI) were examined for individual students in interactive engagement (IE) courses in introductory mechanics at one high school (N=335) and one university (N=292) , and strong, positive correlations were found for both populations ( r=0.57 and r=0.46 , respectively). These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawson’s Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of students’ cognitive skills, as measured either by the SAT or by Lawson’s test. While Lawson’s test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of students’ reasoning abilities. Knowing the students’ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve students’ cognitive level.

Vincent P. Coletta; Jeffrey A. Phillips; Jeffrey J. Steinert

2007-01-01

230

Use of Z-scores to rank applicants to professional degree programs.  

UK PubMed Central (United Kingdom)

Criteria for assessing suitability of applicants for professional degree programs such as veterinary medicine are usually treated as distinct components of a composite scoring procedure that determines applicant ranking. Some components are valued more than others, which is reflected in the relative weights assigned to each component. However, the patterns of dispersal of individual components have the potential to alter the assigned relative weights. Components with larger variances can have greater influences on composite scores than intended. Such unintended altered weighting can be avoided through standardization. Yet non-standardized approaches continue to be used for admissions ranking in several programs. In this study, we documented the potential for differential selection of applicants when non-standardized scoring approaches are applied to admissions assessment components. At our medical school, applicants' component scores with differing variances are standardized by determining Z-scores with a mean of 0 and standard deviation of 1 before mathematically combining to calculate composite scores and admissions ranking. We retrospectively and hypothetically ranked one applicant cohort using non-standardized methods and identified differences in ranking between the standardized and non-standardized approaches. Most differences were observed for applicants in the second, third, and fourth quintiles of the admissions rank list, that is, those for whom admissions cut-off decisions make a marked difference. Observations were supported by lower Spearman's rank correlation coefficients in these quintiles. Although standardization of component scores is not a novel topic, we document the implications of using non-standardized scoring approaches for applicant ranking and underscore the importance of standardization of component scores.

Raghavan M; Martin BD; Aoki F; Mackalski B; Christensen H

2013-01-01

231

Scoring Play Combinatorial Games  

CERN Document Server

This thesis will be discussing scoring play combinatorial games and looking at the general structure of these games under different operators. I will also be looking at the Sprague-Grundy values for scoring play impartial games, and demonstrating that there is an easily computable function that will solve a large range of octal games easily. I will also be demonstrating that my theory can readily be applied to the scoring play game of Go and can lead to a much greater understanding of the game.

Stewart, Fraser

2012-01-01

232

Oxford elbow scores in an asymptomatic population.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Patient reported outcome measures (PROMs) are being used increasingly to assess the quality of healthcare delivery in the UK. It is important when using PROMs to know the score of the background population against which any clinical intervention may be benchmarked. The purpose of this study was to measure an elbow specific PROM for the population of the South West Peninsula. METHODS: A cross-sectional survey was undertaken of patients and healthcare professionals from the South West Peninsula population. Participants were asked to complete a simple demographic questionnaire and an Oxford elbow score for each elbow. Respondents with a history of elbow surgery, elbow injury, chronic elbow problems or an incomplete dataset were excluded from the study. RESULTS: A total of 1,765 respondents (3,530 elbows) completed the survey but 567 questionnaires were excluded due to incomplete datasets, pre-existing elbow pathology or age criteria, leaving 1,198 individuals (2,396 elbows) for analysis. The median scores for each decade group were 48, with mean scores ranging from 46.74 to 47.94. There was no significant clinical difference in the scores for age, sex or hand dominance. CONCLUSIONS: When using the Oxford elbow score to assess outcomes after surgery, a normal score should be used as the benchmark. This benchmark is independent of age, sex and hand dominance.

Guyver PM; Cattell AE; Hall MJ; Brinsden MD

2013-09-01

233

Impartial Scoring Play Games  

CERN Multimedia

In this paper we will be examining impartial scoring play games. We first give the basic definitions for what impartial scoring play games are and look at their general structure under the disjunctive sum. We will then examine the game of nim and all octal games, and define a function that can help us analyse these games. We will finish by looking at the properties this function has and give many conjectures about the behaviour this function exhibits.

Stewart, Fraser

2012-01-01

234

Scoring Play Combinatorial Games  

CERN Document Server

In this paper we will discuss scoring play games. We will give the basic definitions for scoring play games, and show that they form a well defined set, with clear and distinct outcome classes under these definitions. We will also show that under the disjunctive sum these games form a semi-group that is closed, partially ordered with distinct equivalence classes that have a unique representative or canonical form.

Stewart, Fraser

2012-01-01

235

Prospective validation of the “rhino conjunctivitis allergy-control-SCORE©” (RC-ACS©)  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Recently we reported the validation of the “Allergy-Control-SCORE© (ACS)” which assesses symptom severity as well as medication use on three dimensions lung, nose and eyes. The aim of this study was to test the validity of the score for eyes and nose. Methods One-hundred-twenty-one consenting subjects (age 19-65y), including 81 patients with allergic rhino-conjunctivitis (RC) and 40 healthy controls, participated in the study. Patients rated daily nasal and eye symptoms using a 4-point scale (none, mild, moderate, and severe) and their use of anti-symptomatic medication. Validation criteria were pollen counts in the course of the study period. Discrimination capacity was analyzed by comparing the rhino-conjunctivitis Allergy-Control-SCORE© (RC-ACS©) values of allergic patients and healthy controls. Convergent reliability was assessed by correlating RC-ACS© values with the global severity of allergy, the quality of life, and the allergy-related medical consultations. Retest reliability was assessed by the correlation of the repeated measured RC-ACS© scores during each of two consecutive weeks. Results Convergent reliability analysis indicated a significant correlation between RC-Allergy-Control-SCORE© and global severity of allergy (r?=?0.691; p?r?=?0.757; p?r?=?0.329; p?=?0.0019). RC-Allergy-Control-SCORE© showed a good retest reliability (r?=?0.813; p? Conclusions The RC-ACS© can be considered as valid and reliable to assess the severity of rhino-conjunctivitis severity in clinical trials and observational studies.

Häfner Dietrich; Reich Kristian; Zschocke Ina; Lotzin Annett; Meyer Hanns; Kettner Jens; Narkus Annemie

2012-01-01

236

The heidelberg sports activity score - a new instrument to evaluate sports activity.  

UK PubMed Central (United Kingdom)

OBJECTIVE: An appropriate measuring instrument for assessing if sports activity changes after a surgical treatment is not available yet. We hypothesised that the Heidelberg Sport Activity Score is a valid and adequate instrument for measuring sport activity in patients before and after operative treatment. DESIGN: This retrospective study presents a new score (Heidelberg Sports Activity Score - HAS) for measuring the sport activity in 11 selected sports. Validity, sensitivity and test-retest-reliability have been assessed. SETTING: The score includes importance of the sports for patients, impairment of the corresponding joint, and frequency and duration of the sporting activities undertaken. The HAS was validated using 3 criteria: external validation, internal comparison of groups and correlation with the Tegner Score. PATIENTS: A total of 655 patients were recruited for this study. The inclusion criterion was a planned or already received reconstruction (such as a high tibial osteotomy or implantation of a hip or knee prosthesis). The sport activity of these patients was evaluated before and after treatment. MAIN OUTCOME MEASUREMENT: The mean HAS was 32.1 points preoperatively and 37.0 postoperatively (p=0.017). RESULTS: A high correlation was found between the HAS and the Tegner Score (TS) (r=0.729; p=0.010). The Test-Retest- Reliability was performed within a time interval of 2 weeks and a significant correlation of r=0.752 was found (p<0.01). Sensitivity was analysed using a sample of patients before and after high tibial osteotomy. CONCLUSIONS: The HAS is a new, easy to use, effective and valid measuring instrument for the assessment of sports activity in patients before and after operative treatment.

Seeger J; Weinmann S; Schmitt H; Bruckner T; Krueger M; Clarius M

2013-01-01

237

College Math Assessment: SAT Scores vs. College Math Placement Scores  

Science.gov (United States)

Many colleges and university's use SAT math scores or math placement tests to place students in the appropriate math course. This study compares the use of math placement scores and SAT scores for 188 freshman students. The student's grades and faculty observations were analyzed to determine if the SAT scores and/or college math assessment scores

Foley-Peres, Kathleen; Poirier, Dawn

2008-01-01

238

Genetic effect on apgar score  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Os coeficientes de correlação intraclasse foram calculados para os índices de Apgar 1 e 5 minutos após o nascimento de 604 pares de gêmeos em uma maternidade do sudeste brasileiro, depois que esses índices foram ajustados para idade gestacional e sexo. Os dados obtidos apoiaram a hipótese genética apenas em relação ao primeiro índice de Apgar, provavelmente porque ele é menos influenciado pelo ambiente do que 4 minutos depois, quando os recém-nascidos já est (more) iveram sob os cuidados de uma equipe de neonatologistas. Os gêmeos nascidos em primeiro lugar apresentaram, em média, melhor estado clínico que os nascidos em segundo lugar, visto que os primeiros mostraram uma proporção de índices de Apgar inferiores a 7 significativamente menor do que os nascidos em segundo lugar, tanto um minuto (17,5% contra 29,8%) quanto cinco minutos após o nascimento (7,2% contra 11,9%). A proporção de recém-nascidos com índices de Apgar que indicam bom prognóstico foi significativamente menor nos gêmeos do que em 1.522 conceptos únicos nascidos na mesma maternidade. Índices de Apgar menores do que 7, obtidos um e cinco minutos após o nascimento, foram encontrados respectivamente em 9,2% e em 3,4% dos recém-nascidos de parto único. Abstract in english Intraclass correlation coefficients for one- and five-min Apgar scores of 604 twin pairs born at a southeastern Brazilian hospital were calculated, after adjusting these scores for gestational age and sex. The data support a genetic hypothesis only for 1-min Apgar score, probably because it is less affected by the environment than 4 min later, after the newborns have been under the care of a neonatology team. First-born twins exhibited, on average, better clinical conditi (more) ons than second-born twins. The former showed a significantly lower proportion of Apgar scores under seven than second-born twins, both at 1 min (17.5% vs. 29.8%) and at 5 min (7.2% vs. 11.9%). The proportion of children born with "good" Apgar scores was significantly smaller among twins than among 1,522 singletons born at the same hospital. Among the latter, 1- and 5-min Apgar scores under seven were exhibited by 9.2% and 3.4% newborns, respectively.

Franchi-Pinto, Carla; Colletto, Glória Maria Duccini Dal; Krieger, Henrique; Beiguelman, Bernardo

1999-03-01

239

Correlación entre las buenas prácticas de manufactura y el cumplimiento de los criterios microbiológicos en la fabricación de helados en Chile/ Correlation between the good manufacturing practices and compliance with microbiological criteria in the manufacture of ice cream in Chile  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Las Buenas Prácticas de Manufacturas (BPM) son una herramienta básica para obtener un producto alimenticio seguro para consumo humano. El objetivo de este estudio fue determinar el porcentaje de cumplimiento de BPM y su correlación con la aceptación de criterios microbiológicos en fábricas y muestras de helados de Ñuble, Chile, de acuerdo al Reglamento Sanitario de Alimentos chilenos. Se analizaron auditorías de BPM aplicadas por fiscalizadores de Secretaría Regi (more) onal Ministerial (SEREMI) de Salud Ñuble, a 40 fábricas de helados y los resultados microbiológicos de 435 muestras de helados entre los años 2005 y 2010. Se determinó que el 55,2% de las muestras no cumplieron para RAM (105 UFC/g) y coliformes (102 UFC/g) y 4,6% para Staphylococcus aureus (102 UFC/g), en cambio el 100% cumplieron para Salmonella spp. Los mayores RAM fueron en verano con 60% de rechazo. El 67% de auditorías de BPM alcanzaron valores superiores al mínimo (70% de cumplimiento), las instalaciones fue el ítem mejor evaluado (88,4%), y capacitación del personal el peor (20,3 %). La correlación entre los resultados de auditorías de BPM y criterios microbiológicos permitió comprobar que con un porcentaje igual o superior al 80% de cumplimiento de BPM se aseguraría la calidad microbiológica de helados, disminuyendo con ello el riesgo en la salud del consumidor. Abstract in english The Good Manufacturing Practices (GMP) is a basic tool to obtain safe foodstuffs for human consumption. The main goal of this research was to determine the percentage of compliance with GMP in ice cream factories and its correlation with the acceptance of microbiological criteria in samples of ice cream, according to the Sanitary Chilean Food Regulation. Inspectors from the Ministerial Regional Secretariat (SEREMI) of Health Ñuble audited GMP in 40 ice cream factories an (more) d 435 microbial analyses from ice cream samples taken between the years 2005 and 2010 were analyzed. Results showed that 55.2% of samples failed in RAM (105 UFC/g) and coliform (102 UFC/g) and 4.6% for Staphylococcus aureus (102 UFC/g) and 100% for Salmonella spp. The biggest RAM was during summer with 60% rejection. Sixty seven% of inspections of GMP reached values above the minimum (70% compliance). Facilities were the best item assessed (88.4%), and training was the worst (20.3%). The correlation between the results of audits of GMP and microbiological criteria allowed proving that with a percentage equal to or greater than 80% compliance with GMP would ensure the microbiological quality of ice cream, thereby decreasing the risk for consumer health.

Bastías M, José Miguel; Cuadra H, Marcela; Muñoz F, Ociel; Quevedo L, Roberto

2013-06-01

240

Naturalness and Naturalness Criteria  

CERN Document Server

Barbieri and Giudice's sensitivity criteria is widely used to judge naturlaness properities of high energy physics models, we analysis three widely ignored problems of this criteria and argue that the sensitivity criteria can not reflect the naturalness level, then we proposed a new criteria to solve these problems.

Yan, S

2005-01-01

 
 
 
 
241

Pain dominates summed scores for hindfoot and ankle trauma.  

UK PubMed Central (United Kingdom)

BACKGROUND: Outcomes in clinical orthopaedic research are often presented as a summed functional score, without the individual component scores. Thus, there is little information about the effect of each component score on the overall score in hindfoot and ankle trauma. The purpose of this study was to determine which subscores were most responsible for the overall variation in summed scores and to evaluate the correlation of multiple scoring systems after foot and ankle fractures or reconstruction. METHODS: One hundred fifty-eight patients were evaluated after open reduction internal fixation of the calcaneus, open reduction internal fixation of the plafond, or ankle fusion with the Short Form 36, American Orthopedic Foot and Ankle Society (AOFAS), and Maryland scoring systems. Correlations were made between summed scores using a Pearson correlation matrix and the percentage of overall variation of the summed score that is accounted for by the answer to the pain question within the score. RESULTS: For all 3 subsets of patients, there was strong statistical correlation of the Short Form 36 physical component summary, AOFAS, and Maryland scores (P < 0.001). The strongest correlation was between the AOFAS and the Maryland scores for each subset: calcaneus (r = 0.957, P < 0.0001), pilon (r = 0.946, P < 0.0001), and ankle fusion (r = 0.944, P < 0.0001). The pain subscore accounted for almost the entire variation in the summed score, being responsible for 80% to 86% of the overall variation. There was minimal change in overall variation when physical examination was factored into the analysis. CONCLUSIONS: Pain dominates the variation in summed scores for hindfoot and ankle trauma and reconstruction. We strongly recommend that when summed scores are used that the individual components are reported.

Tornetta P 3rd; Qadir R; Sanders R

2013-08-01

242

Syncopation and the score.  

UK PubMed Central (United Kingdom)

The score is a symbolic encoding that describes a piece of music, written according to the conventions of music theory, which must be rendered as sound (e.g., by a performer) before it may be perceived as music by the listener. In this paper we provide a step towards unifying music theory with music perception in terms of the relationship between notated rhythm (i.e., the score) and perceived syncopation. In our experiments we evaluated this relationship by manipulating the score, rendering it as sound and eliciting subjective judgments of syncopation. We used a metronome to provide explicit cues to the prevailing rhythmic structure (as defined in the time signature). Three-bar scores with time signatures of 4/4 and 6/8 were constructed using repeated one-bar rhythm-patterns, with each pattern built from basic half-bar rhythm-components. Our manipulations gave rise to various rhythmic structures, including polyrhythms and rhythms with missing strong- and/or down-beats. Listeners (N?=?10) were asked to rate the degree of syncopation they perceived in response to a rendering of each score. We observed higher degrees of syncopation in time signatures of 6/8, for polyrhythms, and for rhythms featuring a missing down-beat. We also found that the location of a rhythm-component within the bar has a significant effect on perceived syncopation. Our findings provide new insight into models of syncopation and point the way towards areas in which the models may be improved.

Song C; Simpson AJ; Harte CA; Pearce MT; Sandler MB

2013-01-01

243

Siena EVAR Score.  

UK PubMed Central (United Kingdom)

AIM: Although several randomized trial and monocentric study reported good results EVAR of abdominal aortic aneurysm (AAA), the long-term results of EVAR is still debated for the incidence of complication and the necessity of reintervention and or surgical conversion. The aim of the present study was to generate a score to grade the risk of reintervention/conversion after EVAR. METHODS: We present a five-year prospective study. All patients with AAA and treated by EVAR were inserted in the study. Patients with ruptured AAA or treated with fenestrated-graft or chimney technique were excluded from the analysis. The rates of reintervention, surgical conversion and aneurysm-related death were recorded at 6 months after the procedure. Complication predictors were analyzed and was generated a numeric score for all the variables to predict the patient individual risk. RESULTS: During the study period 976 EVAR procedures were successfully performed. No patients were lost during follow-up. We report 23 reinterventions (2.35%), the majority were performed electively. In six cases (0.61%) was performed conversion to surgical repair (1 graft infection, 3 for continuous growing of the aneurysmal sac and 2 cases for a ruptured AAA). In our experience, we report 4 deaths (0.4%) due to aneurysm rupture (1 case), acute myocardial infarction (2 cases) and colon cancer (1 case). The procedures were defined at low, moderate or high risk, respectively, according to whether the Siena EVAR Score was defined as EVAR1 (score <3), EVAR2 (3-6) or EVAR3 (>6). CONCLUSION: Our Score could be an useful tool to predict patients individual risk after EVAR but, to be validated, needs to be analyzed in independents cohorts in different Center.

Setacci F; Sirignano P; Galzerano G; De Donato G; Ceriello D; Paroni G; Cappelli A; Setacci C

2012-04-01

244

Syncopation and the score.  

Science.gov (United States)

The score is a symbolic encoding that describes a piece of music, written according to the conventions of music theory, which must be rendered as sound (e.g., by a performer) before it may be perceived as music by the listener. In this paper we provide a step towards unifying music theory with music perception in terms of the relationship between notated rhythm (i.e., the score) and perceived syncopation. In our experiments we evaluated this relationship by manipulating the score, rendering it as sound and eliciting subjective judgments of syncopation. We used a metronome to provide explicit cues to the prevailing rhythmic structure (as defined in the time signature). Three-bar scores with time signatures of 4/4 and 6/8 were constructed using repeated one-bar rhythm-patterns, with each pattern built from basic half-bar rhythm-components. Our manipulations gave rise to various rhythmic structures, including polyrhythms and rhythms with missing strong- and/or down-beats. Listeners (N?=?10) were asked to rate the degree of syncopation they perceived in response to a rendering of each score. We observed higher degrees of syncopation in time signatures of 6/8, for polyrhythms, and for rhythms featuring a missing down-beat. We also found that the location of a rhythm-component within the bar has a significant effect on perceived syncopation. Our findings provide new insight into models of syncopation and point the way towards areas in which the models may be improved. PMID:24040323

Song, Chunyang; Simpson, Andrew J R; Harte, Christopher A; Pearce, Marcus T; Sandler, Mark B

2013-09-10

245

Automated Essay Scoring  

Directory of Open Access Journals (Sweden)

Full Text Available Automated Essay Scoring Semire DIKLI Florida State University Tallahassee, FL, USA ABSTRACT The impacts of computers on writing have been widely studied for three decades. Even basic computers functions, i.e. word processing, have been of great assistance to writers in modifying their essays. The research on Automated Essay Scoring (AES) has revealed that computers have the capacity to function as a more effective cognitive tool (Attali, 2004). AES is defined as the computer technology that evaluates and scores the written prose (Shermis & Barrera, 2002; Shermis & Burstein, 2003; Shermis, Raymat, & Barrera, 2003). Revision and feedback are essential aspects of the writing process. Students need to receive feedback in order to increase their writing quality. However, responding to student papers can be a burden for teachers. Particularly if they have large number of students and if they assign frequent writing assignments, providing individual feedback to student essays might be quite time consuming. AES systems can be very useful because they can provide the student with a score as well as feedback within seconds (Page, 2003). Four types of AES systems, which are widely used by testing companies, universities, and public schools: Project Essay Grader (PEG), Intelligent Essay Assessor (IEA), E-rater, and IntelliMetric. AES is a developing technology. Many AES systems are used to overcome time, cost, and generalizability issues in writing assessment. The accuracy and reliability of these systems have been proven to be high. The search for excellence in machine scoring of essays is continuing and numerous studies are being conducted to improve the effectiveness of the AES systems.

Semire DIKLI

2006-01-01

246

Ki-67 expression score correlates to survival rate in gastrointestinal stromal tumors (GIST)/ Escore de expressão de Ki-67 correlaciona-se com taxa de sobrevida em tumores estromais gastrointestinais (GIST)  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVO: Avaliar a expressão imunoistoquímica de p16, Ki-67, p53 e Bcl-2 proteínas em tumores gastrointestinais estromais (GIST); determinar a possível associação entre essas variáveis e fatores clínicos e histopatológicos de câncer, e para verificar o valor prognóstico destas variáveis (sobrevivência e recorrência). MÉTODOS: Uma amostra de 55 pacientes tratados cirurgicamente para GIST em três hospitais foi estudada. Os tumores extirpados cirurgicamente (more) foram confirmados como GIST por KIT, vimentina, proteína desmina S100, CD117, 1A4 e avaliação de CD34 em blocos de parafina. RESULTADOS: Apenas nove (16%) casos de GIST foram positivos para p53, p16 foi positiva em 43,6%, 80% dos GIST apresentaram coloração para Bcl-2. O índice proliferativo (expresso como a proporção de células positivas), avaliado pela expressão imunoistoquímica de Ki-67, foi elevado em 49% dos casos. Escores de Ki-67 elevados foram associados com alto grau histológico (p=0,0026) e índice de mitose, MI (p=0,0001). Alto índice de Ki-67 foi associado à morte. Expressão da p53, p16 e Bcl-2 não se correlacionou com as variáveis morfológicas ou clínicas. CONCLUSÕES: A avaliação imunoistoquímica de Ki-67 deve ser incluída na avaliação pré-operatória de biópsias ou peças cirúrgicas de GIST como uma ferramenta prognóstica para o estadiamento clínico, e todas as outras proteínas estudadas (Bcl-2, p53 e p16) não desempenharam um papel no processo metabólico ou carcinogênico em GIST, mantendo-se sem valor prognóstico. Abstract in english PURPOSE: To evaluate the immunohistochemical expression of p16, Ki-67, p53 and Bcl-2 proteins in gastrointestinal stromal tumors (GIST); to assess the possible association between these variables and clinical and histopathological factors of cancer; and to check for prognostic value of these variables (survival and recurrence). METHODS: A sample of 55 patients treated surgically for GIST in three hospitals was studied. The surgically excised tumors were confirmed as GIST (more) by KIT, vimentin, desmin S100 protein, CD117, 1A4 and CD34 assessment in paraffin blocks. RESULTS: Only 9 (16%) cases of GIST were positive for p53, p16 was positive among 43.6%; 80% of GISTs showed staining for Bcl-2. The proliferative index (expressed as the proportion of positive cells) assessed by immunohistochemical expression of Ki-67 was high in 49% of cases. Elevated Ki-67 scores were associated to high histological grade (p=0.0026) and mitosis index, MI (p=0.0001). High Ki-67 index was associated to death. Expression of p53, p16 and Bcl-2 did not correlate to morphological or clinical variables. CONCLUSIONS: Ki-67 immunohistochemical evaluation should be included in preoperative evaluation of GIST biopsies or surgical specimens as a prognostic tool for clinical staging; and all other proteins studied (Bcl-2, p53 and p16) did not play a role in GIST metabolic or carcinogenic process, remaining without prognostic value.

Artigiani Neto, Ricardo; Logullo, Angela Flavia; Stávale, João Norberto; Lourenço, Laércio Gomes

2012-05-01

247

Ki-67 expression score correlates to survival rate in gastrointestinal stromal tumors (GIST) Escore de expressão de Ki-67 correlaciona-se com taxa de sobrevida em tumores estromais gastrointestinais (GIST)  

Directory of Open Access Journals (Sweden)

Full Text Available PURPOSE: To evaluate the immunohistochemical expression of p16, Ki-67, p53 and Bcl-2 proteins in gastrointestinal stromal tumors (GIST); to assess the possible association between these variables and clinical and histopathological factors of cancer; and to check for prognostic value of these variables (survival and recurrence). METHODS: A sample of 55 patients treated surgically for GIST in three hospitals was studied. The surgically excised tumors were confirmed as GIST by KIT, vimentin, desmin S100 protein, CD117, 1A4 and CD34 assessment in paraffin blocks. RESULTS: Only 9 (16%) cases of GIST were positive for p53, p16 was positive among 43.6%; 80% of GISTs showed staining for Bcl-2. The proliferative index (expressed as the proportion of positive cells) assessed by immunohistochemical expression of Ki-67 was high in 49% of cases. Elevated Ki-67 scores were associated to high histological grade (p=0.0026) and mitosis index, MI (p=0.0001). High Ki-67 index was associated to death. Expression of p53, p16 and Bcl-2 did not correlate to morphological or clinical variables. CONCLUSIONS: Ki-67 immunohistochemical evaluation should be included in preoperative evaluation of GIST biopsies or surgical specimens as a prognostic tool for clinical staging; and all other proteins studied (Bcl-2, p53 and p16) did not play a role in GIST metabolic or carcinogenic process, remaining without prognostic value.OBJETIVO: Avaliar a expressão imunoistoquímica de p16, Ki-67, p53 e Bcl-2 proteínas em tumores gastrointestinais estromais (GIST); determinar a possível associação entre essas variáveis e fatores clínicos e histopatológicos de câncer, e para verificar o valor prognóstico destas variáveis (sobrevivência e recorrência). MÉTODOS: Uma amostra de 55 pacientes tratados cirurgicamente para GIST em três hospitais foi estudada. Os tumores extirpados cirurgicamente foram confirmados como GIST por KIT, vimentina, proteína desmina S100, CD117, 1A4 e avaliação de CD34 em blocos de parafina. RESULTADOS: Apenas nove (16%) casos de GIST foram positivos para p53, p16 foi positiva em 43,6%, 80% dos GIST apresentaram coloração para Bcl-2. O índice proliferativo (expresso como a proporção de células positivas), avaliado pela expressão imunoistoquímica de Ki-67, foi elevado em 49% dos casos. Escores de Ki-67 elevados foram associados com alto grau histológico (p=0,0026) e índice de mitose, MI (p=0,0001). Alto índice de Ki-67 foi associado à morte. Expressão da p53, p16 e Bcl-2 não se correlacionou com as variáveis morfológicas ou clínicas. CONCLUSÕES: A avaliação imunoistoquímica de Ki-67 deve ser incluída na avaliação pré-operatória de biópsias ou peças cirúrgicas de GIST como uma ferramenta prognóstica para o estadiamento clínico, e todas as outras proteínas estudadas (Bcl-2, p53 e p16) não desempenharam um papel no processo metabólico ou carcinogênico em GIST, mantendo-se sem valor prognóstico.

Ricardo Artigiani Neto; Angela Flavia Logullo; João Norberto Stávale; Laércio Gomes Lourenço

2012-01-01

248

Fetal Biophysical Profile Scoring  

Directory of Open Access Journals (Sweden)

Full Text Available   "nFetal biophysical profile scoring is a sonographic-based method of fetal assessment first described by Manning and Platt in 1980. "nThe biophysical profile score was developed as a method to integrate real-time observations of the fetus and his/her intrauterine environment in order to more comprehensively assess the fetal condition. These findings must be evaluated in the context of maternal/fetal history (i.e., chronic hypertension, post-dates, intrauterine growth restriction, etc), fetal structural integrity (presence or absence of congenital anomalies), and the functionality of fetal support structures (placental and umbilical cord). For example, acute asphyxia due to placental abruption may result in an absence of the acute variables of the biophysical profile score (fetal breathing movements, fetal movement, fetal tone, and fetal heart rate reactivity) with a normal amniotic fluid volume. With post maturity the asphyxial event may be intermittent and chronic resulting in a decrease in amniotic fluid volume, but with the acute variables remaining normal. "nWhile the 5 components of the biophysical profile score have remained unchanged since 1980 (Manning, 1980), the definitions of a normal and abnormal parameter have evolved with increasing experience. "nIn 1984 the definition of oligohydramnios was increased from < 1cm pocket of fluid to < 2.0 x 1.0 cm pocket. Oligohydramnios is now defined as a pocket of amniotic fluid < 2.0 x 2.0 cm (Manning, 1995a) "nIf the four ultrasound variables are normal, the accuracy of the biophysical profile score was not found to be significantly improved by adding the non-stress test. As a result, in 1987 the profile score was modified to incorporate the non-stress test only when one of the ultrasound variables was abnormal (Manning 1987). Table 1 outlines the current definitions for quantifying a variable as present or absent. "nEach of the 5 components of the biophysical profile score does not have equal significance. Fetal breathing movements, amniotic fluid volume, and the non-stress test are the most powerful variables. For example, when the biophysical profile score is 2, the perinatal mortality varies between 428/1000 with only fetal movement present to 66/1000 if the non-stress test is reactive and all of the ultrasound parameters are absent (Manning 1990b). Some authors have, therefore, proposed utilization of a modified biophysical profile that incorporates only the non-stress test and amniotic fluid volume (Miller 1996). Although the positive predictive value of these 2 tests is equivalent to a biophysical profile score of 6, the perinatal mortality is still increased over a normal test score of 8 or 10 (Manning 1990b). The false positive rate with the modified biophysical profile score is also substantially higher. "nConclusions: The fetus expresses its well being or compromised status through a number of different biophysical activities that are controlled by different central nervous system centers. The utilization of the biophysical score for antepartum surveillance in high-risk patients has resulted in a reduction in perinatal mortality when compared to historical controls. The appropriate management of the viable fetus with an abnormal biophysical profile score may also decrease long-term neurological morbidity (Manning 1998). "nIt is unlikely that in the future additional variables will be added to the biophysical profile score. However, perhaps the incorporation of the fetal state (i.e., eye movements) and Doppler flow studies of specific fetal vessels (umbilical artery, middle cerebral artery, ductus venosus) will be incorporated into a complete assessment of the fetal condition "n "nTable 1. Components of the 30 Minute Biophysical Profile Score "nComponent "nDefinition "nFetal movements "n> 3 body or limb movements "nFetal tone "nOne episode of active extension and flexion of the limbs; opening and closing of hand "nFetal breathing movements

H.R. HaghighatKhah; M. Sanei Taheri

2009-01-01

249

Relationship between motor performance and physical fitness score in 7- to 8-year-old children.  

Directory of Open Access Journals (Sweden)

Full Text Available There are many tests for the evaluation of motor performance or physical fitness that take into account different criteria such as movement forms and patterns, time, distance, and repetitions of each task for the analysis of performance. The aim of this study was to investigate the relationship between motor performance and physical fitness scores in children. Fifty children of both genders aged 7 to 8 years (25 boys and 25 girls) participated in this study. The Test of Gross Motor Development – Second Edition (TGMD-2) was used for the evaluation of motor performance. Physical fitness was assessed by three specific tests proposed by the American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD). The results showed statistical significance and weak correlations among some skills such as run, horizontal jump, hop, leap, underhand roll, and medicine ball throw. The equivalent use of both tests may not be adequate since each test has its own peculiarities in terms of assessment criteria.

Ruy Jornada Krebs; Marcelo Gonçalves Duarte; Glauber Carvalho Nobre; Patrik Felipe Nazario; João Otacilio Libardoni dos Santos

2011-01-01

250

Correlation of the Health Sciences Reasoning Test with student admission variables.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To assess the association between scores on the Health Sciences Reasoning Test (HSRT) and pharmacy student admission variables. METHODS: During the student admissions process, cognitive data, including undergraduate grade point average and Pharmacy College Admission Test (PCAT) scores, were collected from matriculating doctor of pharmacy (PharmD) students. Between 2007 and 2009, the HSRT was administered to 329 first-year PharmD students. Correlations between HSRT scores and cognitive data, previous degree, and gender were examined. RESULTS: After controlling for other predictors, 3 variables were significantly associated with HSRT scores: percentile rank on the reading comprehension (p<0.001), verbal (p<0.001), and quantitative (p<0.001) subsections of the PCAT. CONCLUSIONS: Scores on the reading comprehension, verbal, and quantitative sections of the PCAT were significantly associated with HSRT scores. Some elements of critical thinking may be measured by these PCAT subsections. However, the HSRT offers information absent in standard cognitive admission criteria.

Cox WC; Persky A; Blalock SJ

2013-08-01

251

Brazilian catfish parasitized by Epistylis sp. (Ciliophora, Epistylididae), with description of parasite intensity score.  

UK PubMed Central (United Kingdom)

The determination of mean intensity of parasitism for colony-forming sessile protozoan such as Epistylis has been a great problem in parasitological studies. Some alternatives have been proposed by researchers for laboratory and field conditions. This study describes the criteria to establish the parasitic intensity score for epistylidid infestation in fish. Parasite distribution and the host-parasite relationship in four species of Brazilian cultured catfish and their hybrids are discussed. The highest prevalence rates were found in the hybrid jundiara, Leiarius marmoratus male × Pseudoplatystoma reticulatum female (96.4 %), followed by jurupoca, Hemisorubim platyrhynchos (60 %), and the hybrid surubim, Pseudoplatystoma corruscans male × P. reticulatum female (52.7 %). Positive correlation between parasitic intensity score and the fish size, weight, and relative condition factor were also observed. These findings indicate that Epistylis infestation in Brazilian catfish is an emerging disease in cultured fish.

de Pádua SB; Ishikawa MM; Ventura AS; Jerônimo GT; Martins ML; Tavares LE

2013-01-01

252

Mottling score predicts survival in septic shock.  

UK PubMed Central (United Kingdom)

BACKGROUND: Experimental and clinical studies have identified a crucial role of microcirculation impairment in severe infections. We hypothesized that mottling, a sign of microcirculation alterations, was correlated to survival during septic shock. METHODS: We conducted a prospective observational study in a tertiary teaching hospital. All consecutive patients with septic shock were included during a 7-month period. After initial resuscitation, we recorded hemodynamic parameters and analyzed their predictive value on mortality. The mottling score (from 0 to 5), based on mottling area extension from the knees to the periphery, was very reproducible, with an excellent agreement between independent observers [kappa = 0.87, 95% CI (0.72-0.97)]. RESULTS: Sixty patients were included. The SOFA score was 11.5 (8.5-14.5), SAPS II was 59 (45-71) and the 14-day mortality rate 45% [95% CI (33-58)]. Six hours after inclusion, oliguria [OR 10.8 95% CI (2.9, 52.8), p = 0.001], arterial lactate level [<1.5 OR 1; between 1.5 and 3 OR 3.8 (0.7-29.5); >3 OR 9.6 (2.1-70.6), p = 0.01] and mottling score [score 0-1 OR 1; score 2-3 OR 16, 95% CI (4-81); score 4-5 OR 74, 95% CI (11-1,568), p < 0.0001] were strongly associated with 14-day mortality, whereas the mean arterial pressure, central venous pressure and cardiac index were not. The higher the mottling score was, the earlier death occurred (p < 0.0001). Patients whose mottling score decreased during the resuscitation period had a better prognosis (14-day mortality 77 vs. 12%, p = 0.0005). CONCLUSION: The mottling score is reproducible and easy to evaluate at the bedside. The mottling score as well as its variation during resuscitation is a strong predictor of 14-day survival in patients with septic shock.

Ait-Oufella H; Lemoinne S; Boelle PY; Galbois A; Baudel JL; Lemant J; Joffre J; Margetis D; Guidet B; Maury E; Offenstadt G

2011-05-01

253

Introduction of a new standardized assessment score of spine morphology in osteogenesis imperfecta  

International Nuclear Information System (INIS)

Purpose: Osteogenesis imperfecta (OI) is a rare hereditary disease leading to multiple bone deformities and fractures. In the absence of causal therapy, a symptomatic approach is based on treatment with bisphosphonates and physiotherapy. The clinical and radiological manifestations vary. Therefore, standardization and quantification for an objective comparison, especially during therapy, are required. In this paper, radiological changes of the spine are quantified according to their clinical relevance to define a scoring system that transfers the morphological changes into a single value representing the severity of the disease. Materials and Methods: 268 lateral spine X-rays of 95 patients with OI (median age 5.6 years) were assessed. The findings were classified based on their clinical relevance. Results: The three criteria, vertebral compression, thoracolumbar kyphosis and deformity type, were quantified in a new grading system. Based on this, a 'severity classification' (1 to 5) was defined with implications for diagnostics and treatment. A mathematical formula that takes into account the three criteria and their correlations to clinical relevance, resulting in a 'severity score', was developed. Conclusion: 'Severity classification' and 'severity score' introduce a new concept for a standardized evaluation of spine X-rays in patients with OI. For both scientific and routine purposes, it provides the user with a simple and easy-to-handle tool for assessing and comparing different stages of severity prior to and during therapy with detailed accuracy. (orig.)

2012-01-01

254

Introduction of a new standardized assessment score of spine morphology in osteogenesis imperfecta  

Energy Technology Data Exchange (ETDEWEB)

Purpose: Osteogenesis imperfecta (OI) is a rare hereditary disease leading to multiple bone deformities and fractures. In the absence of causal therapy, a symptomatic approach is based on treatment with bisphosphonates and physiotherapy. The clinical and radiological manifestations vary. Therefore, standardization and quantification for an objective comparison, especially during therapy, are required. In this paper, radiological changes of the spine are quantified according to their clinical relevance to define a scoring system that transfers the morphological changes into a single value representing the severity of the disease. Materials and Methods: 268 lateral spine X-rays of 95 patients with OI (median age 5.6 years) were assessed. The findings were classified based on their clinical relevance. Results: The three criteria, vertebral compression, thoracolumbar kyphosis and deformity type, were quantified in a new grading system. Based on this, a 'severity classification' (1 to 5) was defined with implications for diagnostics and treatment. A mathematical formula that takes into account the three criteria and their correlations to clinical relevance, resulting in a 'severity score', was developed. Conclusion: 'Severity classification' and 'severity score' introduce a new concept for a standardized evaluation of spine X-rays in patients with OI. For both scientific and routine purposes, it provides the user with a simple and easy-to-handle tool for assessing and comparing different stages of severity prior to and during therapy with detailed accuracy. (orig.)

Koerber, F.; Schulze Uphoff, U.; Koerber, S.; Maintz, D. [Koeln Univ. (Germany). Dept. of Radiology; Schoenau, E.; Semler, O. [Koeln Univ. (Germany). Children' s Hospital

2012-08-15

255

Prognostic score-based balance measures can be a useful diagnostic for propensity score methods in comparative effectiveness research.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Examining covariate balance is the prescribed method for determining the degree to which propensity score methods should be successful at reducing bias. This study assessed the performance of various balance measures, including a proposed balance measure based on the prognostic score (similar to a disease risk score), to determine which balance measures best correlate with bias in the treatment effect estimate. STUDY DESIGN AND SETTING: The correlations of multiple common balance measures with bias in the treatment effect estimate produced by weighting by the odds, subclassification on the propensity score, and full matching on the propensity score were calculated. Simulated data were used, based on realistic data settings. Settings included both continuous and binary covariates and continuous covariates only. RESULTS: The absolute standardized mean difference (ASMD) in prognostic scores, the mean ASMD (in covariates), and the mean t-statistic all had high correlations with bias in the effect estimate. Overall, prognostic scores displayed the highest correlations with bias of all the balance measures considered. Prognostic score measure performance was generally not affected by model misspecification, and the prognostic score measure performed well under a variety of scenarios. CONCLUSION: Researchers should consider using prognostic score-based balance measures for assessing the performance of propensity score methods for reducing bias in nonexperimental studies.

Stuart EA; Lee BK; Leacy FP

2013-08-01

256

Developing Scoring Algorithms  

Science.gov (United States)

We developed scoring procedures to convert screener responses to estimates of individual dietary intake for fruits and vegetables (cup equivalents), dairy (cup equivalents), added sugars (tsp), whole grains (ounce equivalents), fiber (g), and calcium (mg) using the What We Eat in America 24-hour dietary recall data from the 2003-2006 NHANES. The following equations were estimated in the NHANES 2003-2006, using SAS PROC REG.

257

Determining ICH Score: can we go beyond?  

Science.gov (United States)

Spontaneous intracerebral hemorrhage (SICH) still presents a great heterogeneity in its clinical evaluation, demonstrating differences in the enrollment criteria used for the study of intracerebral hemorrhage (ICH) treatment. The aim of the current study was to assess the ICH Score, a simple and reliable scale, determining the 30-day mortality and the one-year functional outcome. Consecutive patients admitted with acute SICH were prospectively included in the study. ICH Scores ranged from 0 to 4, and each increase in the ICH Score was associated with an increase in the 30-day mortality and with a progressive decrease in good functional outcome rates. However, the occurrence of a pyramidal pathway injury was better related to worse functional outcome than the ICH Score. The ICH Score is a good predictor of 30-day mortality and functional outcome, confirming its validity in a different socioeconomic populations. The association of the pyramidal pathway injury as an auxiliary variable provides more accurate information about the prognostic evolution. PMID:19722035

Patriota, Gustavo Cartaxo; Silva-Júnior, João Manoel da; Barcellos, Alécio Cristino Evangelista Santos; Silva Júnior, Joaquim Barbosa de Sousa; Toledo, Diogo Oliveira; Pinto, Fernando Campos Gomes; Rotta, José Marcus

2009-09-01

258

Credit scoring for individuals  

Directory of Open Access Journals (Sweden)

Full Text Available Lending money to different borrowers is profitable, but risky. The profits come from the interest rate and the fees earned on the loans. Banks do not want to make loans to borrowers who cannot repay them. Even if the banks do not intend to make bad loans, over time, some of them can become bad. For instance, as a result of the recent financial crisis, the capability of many borrowers to repay their loans were affected, many of them being on default. That’s why is important for the bank to monitor the loans. The purpose of this paper is to focus on credit scoring main issues. As a consequence of this, we presented in this paper the scoring model of an important Romanian Bank. Based on this credit scoring model and taking into account the last lending requirements of the National Bank of Romania, we developed an assessment tool, in Excel, for retail loans which is presented in the case study.

Maria DIMITRIU; Elena Alexandra AVRAMESCU; Razvan Constantin CARACOTA

2010-01-01

259

Determining ICH Score: can we go beyond? Determinando o ICH Score: podemos ir além?  

Directory of Open Access Journals (Sweden)

Full Text Available Spontaneous intracerebral hemorrhage (SICH) still presents a great heterogeneity in its clinical evaluation, demonstrating differences in the enrollment criteria used for the study of intracerebral hemorrhage (ICH) treatment. The aim of the current study was to assess the ICH Score, a simple and reliable scale, determining the 30-day mortality and the one-year functional outcome. Consecutive patients admitted with acute SICH were prospectively included in the study. ICH Scores ranged from 0 to 4, and each increase in the ICH Score was associated with an increase in the 30-day mortality and with a progressive decrease in good functional outcome rates. However, the occurrence of a pyramidal pathway injury was better related to worse functional outcome than the ICH Score. The ICH Score is a good predictor of 30-day mortality and functional outcome, confirming its validity in a different socioeconomic populations. The association of the pyramidal pathway injury as an auxiliary variable provides more accurate information about the prognostic evolution.A hemorragia intracerebral (AVCH) espontânea ainda apresenta grande heterogeneidade em sua avaliação clínica, evidenciando diferenças nos critérios de inclusão utilizados nos estudos de tratamento da hemorragia intracerebral (ICH). O objetivo do presente estudo foi avaliar o ICH Score, uma escala simples e confiável, determinando a mortalidade em 30 dias e o resultado funcional após um ano. Pacientes consecutivos com AVCH espontâneo foram incluídos prospectivamente no estudo. O ICH Score variou de 0 a 4 e cada aumento no ICH Score esteve associado com um aumento na mortalidade em 30 dias e com uma progressiva diminuição nas taxas de bom resultado funcional. Entretanto, a ocorrência de injúria da via piramidal esteve melhor relacionada com um pior resultado funcional do que o ICH Score. O ICH Score é um bom preditor de mortalidade em 30 dias e resultado funcional, confirmando sua validade em diferentes populações socioeconômicas. A associação da injúria da via piramidal como variável auxiliar fornece informações mais precisas sobre a evolução prognóstica.

Gustavo Cartaxo Patriota; João Manoel da Silva-Júnior; Alécio Cristino Evangelista Santos Barcellos; Joaquim Barbosa de Sousa Silva Júnior; Diogo Oliveira Toledo; Fernando Campos Gomes Pinto; José Marcus Rotta

2009-01-01

260

The run-off resistance (ROR) assessed on MR angiograms may serve as a valid scoring system in patients with symptomatic peripheral arterial disease (PAD) and correlates with the ankle-brachial pressure index (ABI)  

International Nuclear Information System (INIS)

[en] Objective: To investigate the correlation between the hemodynamic parameter ankle-brachial pressure index (ABI) and the run-off resistance (ROR) assessed on MR angiograms (MRA) in patients with peripheral arterial disease (PAD) Fontaine Stage I and II and its potential as reliable reporting system in clinical routine. Methods: Contrast-enhanced MRA was performed in 321 PAD patients using a 1.5 T MR scanner with moving bed technique. The ROR and resting ABI were determined in each patient's leg and correlation analysis was performed using the Pearson test. Results: A significant negative correlation (r = ?.513; p

2012-01-01

 
 
 
 
261

Comparison of Araoye's criteria with standard electrocardiographic criteria for diagnosis of left ventricular hypertrophy in Nigerian hypertensives.  

UK PubMed Central (United Kingdom)

BACKGROUND: Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular morbidity and mortality. Various electrocardiographic (ECG) criteria for LHV give poorer performance in black subjects when compared with white subjects. Araoye proposed a code system for improved ECG diagnosis of LVH in blacks. The Araoye's criteria are yet to be validated in black subjects. STUDY DESIGN: Electrocardiograms and echocardiograms were obtained from 100 hypertensive subjects and 60 controls. ECG LVH was determined by the Araoye's code criteria, Sokolow-Lyon; Cornell voltage; and Romhilt-Estes point score. Echocardiographic LVH was defined by LV mass indexed for height at 97.5 percentile of the controls (126 g.m(-1) and 130 g.m(-1) in females and males respectively). RESULTS: The prevalence of echocardiographic LVH indexed for height was 34% and 1.67% in the hypertensive and controls respectively while the prevalence of electrocardiographic LVH among the hypertensives were 18% by Romhilt Estes score, 48% by Sokolow-Lyon's criteria, 22% by Cornell's criteria and 51% by Araoye's criteria. The sensitivity and specificity respectively of the various electrocardiographic criteria were 65.7% and 76.8% for Sokolow-Lyon, 25.7% and 88.8% for Cornell's criteria 25.7% and 92.8% for Romhilt-Estes score and 71.4% and 74.4% for Araoye's criteria. Araoye's criteria did not differ significantly from Sokolow-Lyon criteria in identifying LVH but differed significantly from Cornell and Romhilt-Estes criteria. The number of positive codes in Araoye's criteria was significantly associated with the blood pressures, LV dimensions, and LV mass. CONCLUSION: The Araoye's code system for electrocardiographic diagnosis of LVH offer no comparative advantage over Sokolow-Lyon's criteria. However, the number of positive codes in Araoye's criteria identifies those individuals with more severe LVH.

Dada A; Adebiyi AA; Aje A; Oladapo OO; Falase AO

2006-07-01

262

A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands.  

UK PubMed Central (United Kingdom)

Cowden syndrome (CS) and Bannayan-Riley-Ruvalcaba syndrome are allelic, defined by germline PTEN mutations, and collectively referred to as PTEN hamartoma tumor syndrome. To date, there are no existing criteria based on large prospective patient cohorts to select patients for PTEN mutation testing. To address these issues, we conducted a multicenter prospective study in which 3042 probands satisfying relaxed CS clinical criteria were accrued. PTEN mutation scanning, including promoter and large deletion analysis, was performed for all subjects. Pathogenic mutations were identified in 290 individuals (9.5%). To evaluate clinical phenotype and PTEN genotype against protein expression, we performed immunoblotting (PTEN, P-AKT1, P-MAPK1/2) for a patient subset (n = 423). In order to obtain an individualized estimation of pretest probability of germline PTEN mutation, we developed an optimized clinical practice model to identify adult and pediatric patients. For adults, a semiquantitative score-the Cleveland Clinic (CC) score-resulted in a well-calibrated estimation of pretest probability of PTEN status. Overall, decreased PTEN protein expression correlated with PTEN mutation status; decreasing PTEN protein expression correlated with increasing CC score (p < 0.001), but not with the National Comprehensive Cancer Network (NCCN) criteria (p = 0.11). For pediatric patients, we identified highly sensitive criteria to guide PTEN mutation testing, with phenotypic features distinct from the adult setting. Our model improved sensitivity and positive predictive value for germline PTEN mutation relative to the NCCN 2010 criteria in both cohorts. We present the first evidence-based clinical practice model to select patients for genetics referral and PTEN mutation testing, further supported biologically by protein correlation.

Tan MH; Mester J; Peterson C; Yang Y; Chen JL; Rybicki LA; Milas K; Pederson H; Remzi B; Orloff MS; Eng C

2011-01-01

263

Pronuclear scoring as a predictor of embryo quality in in vitro fertilization program.  

Directory of Open Access Journals (Sweden)

Full Text Available Many strategies have been proposed for the selection of viable embryos for transfer in human assisted reproduction. These have included morphological scoring criteria for 20, 28, 44 and 68 h after insemination. The embryo selection is based on morphology, degree of fragmentation and development to the 8-cell. All have shown some correlation with implantation. However, the overall success of these methods is still limited, with over 50% of all transferred embryos failing to implant. Pronuclear zygote morphology has gained much attention recently due to its positive value in predicting implantation and pregnancy. This prospective study involved 178 conventional IVF patients only. The key aspects of pronuclear scoring and namely the presence of a cytoplasmic halo were related to day 3 of development and morphology in a retrospective study. The Z-score and the presence/absence of a halo had significant effect on the rate of development on day 3 embryo. Low Z-score result in slow development and poor morphology. The absence of a halo also resulted in slow and poor development, low morphology, increased fragmentation.

Magdalena Depa-Martynow; Piotr Jedrzejczak; Leszek Pawelczyk

2008-01-01

264

Significance of preimplantation analysis of kidney biopsies from expanded criteria donors in long-term outcome.  

UK PubMed Central (United Kingdom)

BACKGROUND: The shortage of organs has led to expanding the criteria for donors. Histologic evaluations before transplantation may enable the identification of organs unsuitable for single implantation. The aim of this study was to evaluate the histologic findings as prognostic factors of allograft survival from expanded criteria donors (ECDs). METHODS: We included a cohort of 136 single transplantations with kidneys from ECD and correlated the preimplantation pathologic findings with graft failure. Renal structures from ECD older (n=104) or younger (n=32) than 60 years were evaluated histologically for renal senescence and rated with a total histologic score. A multivariate Cox analysis was performed to identify predictors of graft failure. RESULTS: Glomerulosclerosis was the most prevalent lesion in biopsies from donors older and younger than 60 years (P=0.002); interstitial fibrosis was more severe in biopsies from older donors (P=0.001); older donors showed a higher prevalence of tubular atrophy (P=0.022), and vascular compartment showed no significant differences. Kidney biopsy-based scoring system ranged from 0 to 15 points, indicating the presence of changes in the renal parenchyma. Biopsies with total histologic scores less than or equal to 5 showed significantly better 5-year graft survival than those with scores more than 5 (P<0.001). A preimplantation score more than 5 points remained an independent predictor of graft failure (hazard ratio 6.95; 95% confidence interval 1.57-30). CONCLUSIONS: Histologic analysis of kidney biopsies before transplantation is a valuable tool for facilitating the selection of viable grafts from ECD donors. When the total score is more than 5, single kidney transplantation from ECD should not be recommended for patients similar to this study population.

Navarro MD; López-Andréu M; Rodríguez-Benot A; Ortega-Salas R; Morales ML; López-Rubio F; García PA

2011-02-01

265

Description and validation of a scoring system for tomosynthesis in pulmonary cystic fibrosis  

Energy Technology Data Exchange (ETDEWEB)

To design and validate a scoring system for tomosynthesis (digital tomography) in pulmonary cystic fibrosis. A scoring system dedicated to tomosynthesis in pulmonary cystic fibrosis was designed. Three radiologists independently scored 88 pairs of radiographs and tomosynthesis examinations of the chest in 60 patients with cystic fibrosis and 7 oncology patients. Radiographs were scored according to the Brasfield scoring system and tomosynthesis examinations were scored using the new scoring system. Observer agreements for the tomosynthesis score were almost perfect for the total score with square-weighted kappa >0.90, and generally substantial to almost perfect for subscores. Correlation between the tomosynthesis score and the Brasfield score was good for the three observers (Kendall's rank correlation tau 0.68, 0.77 and 0.78). Tomosynthesis was generally scored higher as a percentage of the maximum score. Observer agreements for the total score for Brasfield score were almost perfect (square-weighted kappa 0.80, 0.81 and 0.85). The tomosynthesis scoring system seems robust and correlates well with the Brasfield score. Compared with radiography, tomosynthesis is more sensitive to cystic fibrosis changes, especially bronchiectasis and mucus plugging, and the new tomosynthesis scoring system offers the possibility of more detailed and accurate scoring of disease severity. (orig.)

Vult von Steyern, Kristina; Bjoerkman-Burtscher, Isabella M.; Bozovic, Gracijela; Wiklund, Marie; Geijer, Mats [Skaane University Hospital, Lund University, Centre for Medical Imaging and Physiology, Lund (Sweden); Hoeglund, Peter [Skaane University Hospital, Competence Centre for Clinical Research, Lund (Sweden)

2012-12-15

266

A novel patellofemoral scoring system for patellofemoral joint status.  

UK PubMed Central (United Kingdom)

BACKGROUND: We were not aware of a well-validated patellofemoral joint-specific scoring system. We performed this study to develop and validate a scoring system (Samsung Medical Center [SMC] patellofemoral scoring system) suitable for the evaluation of patellofemoral joint status. METHODS: We recruited 179 individuals consisting of a study group of 123 patients with anterior knee pain but without pain in another part of the knee, twenty-eight patients with knee pain other than anterior knee pain (group A), and twenty-eight healthy volunteers without knee pain (group B). Items in the development of the scoring system that showed a significant difference between the study group and group A and between the study group and the group B were selected. Test-retest reliability was measured by intraclass correlation coefficient, internal consistency was measured by the Cronbach alpha, content validity was assessed by ceiling and floor effects, and construct validity was determined by the association of the Feller scores and the SMC patellofemoral scores. RESULTS: After the item verification process, seventeen items (eight items for patellofemoral pain and nine items for patellofemoral function) were selected. Test-retest reliability for overall SMC patellofemoral scores showed excellent reliability (intraclass correlation coefficient, 0.85), and internal consistency was excellent (Cronbach alpha, 0.97). Floor and ceiling effects were acceptable (<30%) for all the items of the SMC patellofemoral scoring system, except one: sitting down on a chair, in the patellofemoral function score. The SMC patellofemoral scores showed moderate correlation with the Feller scores (? = -0.45). CONCLUSIONS AND CLINICAL RELEVANCE: The SMC patellofemoral score is a novel scoring system that distinguishes patients with anterior knee pain or patellofemoral dysfunction from patients with knee pain or dysfunction arising from other knee problems, and from those without knee pain. The reliability and validity of the SMC patellofemoral scoring system were verified in the present study.

Lee CH; Ha CW; Kim S; Kim M; Song YJ

2013-04-01

267

The MISSED score, a new scoring system to predict Mortality In Severe Sepsis in the Emergency Department: a derivation and validation study.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To derive and validate a new scoring system to predict in-hospital mortality in septic patients in the emergency department (ED). PATIENTS AND METHOD: Septic patients admitted to the ICU and those in whom early goal-directed therapy (EGDT) was carried out in the ED were identified from the ED record. Univariate and multivariate regression analyses identified independent variables associated with mortality. The variables were given a score weighted by the odds ratio, the sum of which yielded the Mortality In Severe Sepsis in the Emergency Department (MISSED) score. The performance of the MISSED score in predicting mortality was compared with that of the Acute Physiology and Chronic Health Evaluation II (APACHE II) score, the EGDT criteria and the severe sepsis criteria. The Hosmer-Lemeshow test was performed to calibrate the model. RESULTS: Independent variables identified were age at least 65 years, albumin level up to 27 g/l and international normalized ratio of 1.2 or more. The MISSED score ranged from 0-9; cut-off point 5.5. Mortality rates associated with a score of 0, less than 5.5 and 5.5 or more were 7.4, 17.7 and 40.6%, respectively. The sensitivity of the score was 96.8% (95% confidence interval 87.8-99.4%). The mortality rate and specificity associated with a score of 9 were 62.9 and 91.6% respectively. The area under the curve for the MISSED score and the APACHE II score were equal. The performance of the MISSED score of 5.5 or more in predicting mortality was similar to that of the EGDT criteria. The sensitivity of the score was equal to that for the severe sepsis criteria. The Hosmer-Lemeshow test confirmed good calibration. CONCLUSION: The MISSED score should be used in the ED.

Sivayoham N; Rhodes A; Cecconi M

2013-07-01

268

Relationship between Duke Treadmill Score and coronary artery lesion complexity.  

UK PubMed Central (United Kingdom)

PURPOSE: The purpose of this study was to investigate the relationship between the Duke Treadmil Score (DTS) and coronary artery disease (CAD) complexity in patients with suspected coronary artery disease (CAD). METHODS: Sixty five patients who had positive exercise testing for CAD were enrolled. Coronary angiography was performed and Syntax score (SxScore), a marker of CAD complexity, was determined. The relationship between DTC and SxScore then evaluated. RESULTS: There was a strong negative correlation between DTS and SxScore (r = - 0.91, p < 0.001). In addition, patients with higher and intermediate risk as evaluated by DTS had increased SxScore compare to those that were low risk (23 ± 6, 6 ± 5 and 0 ± 0 respectively). CONCLUSIONS: A strong negative correlation was seen between DTS and coronary lesion complexity. By assessing DTS important information about coronary artery lesion complexity can be obtained before invasive coronary angiography.

Acar Z; Korkmaz L; Agac MT; Erkan H; Dursun I; Kalaycioglu E; Kiris G; Celik S

2012-01-01

269

Standard electrocardiographic criteria for left ventricular hypertrophy in Nigerian hypertensives.  

UK PubMed Central (United Kingdom)

OBJECTIVES: Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular morbidity and mortality. Various electrocardiographic criteria for LVH have differing sensitivities and specificities. Most of the available electrocardiographic criteria for LVH have not been evaluated in the African populace. METHODS: Electrocardiograms (ECGs) and echocardiograms were obtained from 100 hypertensive subjects and 60 controls. Electrocardiogram (ECG) LVH was determined by the Sokolow-Lyon, Sokolow-Lyon-Rappaport, Cornell voltage, Romhilt-Estes point score, and the Perugia score criteria. Echocardiographic LVH was defined by LV mass indexed for height at 97.5 percentile of the controls (126 g/m and 130 g/m in females and males respectively). RESULTS: The prevalence of echocardiographic LVH indexed for height was 34% and 1.67% in the hypertensive patients and controls respectively. The prevalence of ECG LVH obtained in the hypertensive patients with the various ECG criteria were 56% for Sokolow-Lyon-Rappaport voltage, 48% for Sokolow-Lyon voltage, 41% for Perugia score, 22% for Cornell sex specific voltage, and 18% for Romhilt-Estes score. Sokolow-Lyon-Rappaport voltage criteria had the best sensitivity (80%) and area under the receiver operating characteristic (ROC) curve while the Romhilt-Estes score had the best specificity (93%). CONCLUSION: Sokolow-Lyon and Sokolow-Lyon-Rappaport voltage criteria combine the best sensitivity and specificity values and would seem better suited for the diagnosis of ECG LVH in Nigerians.

Dada A; Adebiyi AA; Aje A; Oladapo OO; Falase AO

2005-01-01

270

Association between scores in high school, aptitude and achievement exams and early performance in health science college  

Directory of Open Access Journals (Sweden)

Full Text Available This retrospective study was carried out to assess the correlation between admi-ssion criteria to health science colleges, namely, final high school grade and Saudi National Apti-tude and Achievement exams, and early academic performance in these colleges. The study inclu-ded 91 male students studying in the two-year pre-professional program at the King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia. Records of these students were used to extract relevant information and their academic performance (based on the grade point average achieved at the end of the first semester of the pre-professional program), which were analytically studied. Pearson correlation coefficient was used to assess the associa-tions between the different scores. SPSS statistical program (version 12.0) was used for data ana-lyses. We found a strong correlation between the academic performance and the Achievement Exam, Aptitude Exam and high school final grade, with Pearson Correlation Coefficients of 0.96, 0.93, 0.87, respectively. The Saudi National Achievement Exam showed the most significant correla-tion. Our results indicate that academic performance showed good correlation with the admission criteria used, namely final high school grade, Saudi National Aptitude and Achievement Exams.

Al-Alwan Ibrahim

2009-01-01

271

The Apache II scoring system in neurosurgical patients: a comparison with simple Glasgow coma scoring.  

UK PubMed Central (United Kingdom)

In order to compare the predictive value of the Apache II, the Glasgow Coma Scale and Revised Trauma Scoring systems in relation to outcome in a neurosurgical department high dependency unit (HDU), all 109 patients entering the unit under the care of one consultant were studied. All patients in the HDU were self-ventilating, so that motor responses were not suppressed by muscle relaxants or sedation. Initial Minimum and Maximum Glasgow Coma Scale Scores, Revised Trauma Score, Apache II and the Apache minus neurological weighting (Apache-NW) scores, were compared as predictors of outcome (as assessed by the Glasgow Outcome Score at 6 months). Twenty-eight patients had a bad outcome, i.e. Glasgow Outcome Scores 1-3, and 72 individuals a good outcome, i.e. scores 4 or 5. Statistical analysis was by the Spearman Ranked Correlation Test, and comparison of Receiver Operational Characteristics Curves. Data were complete on 100 patients (91.7%) and show the Maximum Glasgow Coma Score, followed by the Apache II score, as the best predictors of outcome analysed. This was also true if all patients except those with head injury were analysed as a group. All scoring systems were significantly better predictors of outcome in the head injured patient. For this group, Apache II had an outcome predictive value of 97% compared with 93% for initial and 95% for minimum GCS. Removing the neurological weighting from Apache II weakened its predictive ability in all patients, emphasizing that it is the neurological status of the patient which best predicts overall functional outcome. Apache II data are also much more time-consuming to collect than GCS data.(ABSTRACT TRUNCATED AT 250 WORDS)

Hartley C; Cozens A; Mendelow AD; Stevenson JC

1995-04-01

272

North sea score card  

Energy Technology Data Exchange (ETDEWEB)

A number of the North Sea oil and gas fields have been developed and produced to a point where it is now possible to compare their historical performance against their original projections. Furthermore, revised forecasts, (which are based on more reliable data) that have been prepared recently for these fields, can also be compared against the original projections. This type of analysis suggests that none of the fields studied for the purpose of this paper merit high scores for good performance. However, despite shortfalls in performance, in most of the fields looked at for this paper the actual cumulative after tax cash flow generated through the end of 1983 was larger than was originally projected. Out of 23 fields reviewed, 17 earned more after tax cash flow through 1983 than originally projected and only 6 fell short of the projections from a cash flow standpoint. These larger cash flows have resulted from the escalation in the price of oil and gas, and, therefore, it could be said that many of these North Sea investments would be ''underwater'' except that they were ''bailed out'' by the price increases that occurred in the late 1970's and early 1980's.

Castle, G.R.

1986-01-01

273

Validity and predictive ability of the juvenile arthritis disease activity score based on CRP versus ESR in a Nordic population-based setting  

DEFF Research Database (Denmark)

OBJECTIVE: To compare the juvenile arthritis disease activity score (JADAS) based on C reactive protein (CRP) (JADAS-CRP) with JADAS based on erythrocyte sedimentation rate (ESR) (JADAS-ESR) and to validate JADAS in a population-based setting.METHODS: The CRP and ESR values and the corresponding JADAS scores (JADAS10/27/71) were compared in a longitudinal cohort study of 389 children newly diagnosed with juvenile idiopathic arthritis (JIA) in the Nordic JIA study. The construct validity and the discriminative and predictive ability of JADAS were assessed during a median disease course of 8 years by comparing JADAS with other measures of disease activity and outcome.RESULTS: At the first study visit the correlation between JADAS27-CRP and JADAS27-ESR was r=0.99 whereas the correlation between CRP and ESR was r=0.57. Children with higher JADAS scores had an increased risk of concomitant pain, physical disability and use of disease-modifying antirheumatic drugs (DMARDs). A higher JADAS score at the first study visit also significantly predicted physical disability, damage and no remission off medication at the final study visit, and also use of DMARDs during the disease course. Sensitivity to change, demonstrated as change in JADAS score compared with the American College of Rheumatology paediatric measures of improvement criteria, mostly showed excellent classification ability.CONCLUSION: The JADAS-CRP and JADAS-ESR correlate closely, show similar test characteristics and are feasible and valid tools for assessing disease activity in JIA.

Nordal, E B; Zak, Marek Stanislaw

2012-01-01

274

Validity and predictive ability of the juvenile arthritis disease activity score based on CRP versus ESR in a Nordic population-based setting.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To compare the juvenile arthritis disease activity score (JADAS) based on C reactive protein (CRP) (JADAS-CRP) with JADAS based on erythrocyte sedimentation rate (ESR) (JADAS-ESR) and to validate JADAS in a population-based setting. METHODS: The CRP and ESR values and the corresponding JADAS scores (JADAS10/27/71) were compared in a longitudinal cohort study of 389 children newly diagnosed with juvenile idiopathic arthritis (JIA) in the Nordic JIA study. The construct validity and the discriminative and predictive ability of JADAS were assessed during a median disease course of 8 years by comparing JADAS with other measures of disease activity and outcome. RESULTS: At the first study visit the correlation between JADAS27-CRP and JADAS27-ESR was r=0.99 whereas the correlation between CRP and ESR was r=0.57. Children with higher JADAS scores had an increased risk of concomitant pain, physical disability and use of disease-modifying antirheumatic drugs (DMARDs). A higher JADAS score at the first study visit also significantly predicted physical disability, damage and no remission off medication at the final study visit, and also use of DMARDs during the disease course. Sensitivity to change, demonstrated as change in JADAS score compared with the American College of Rheumatology paediatric measures of improvement criteria, mostly showed excellent classification ability. CONCLUSION: The JADAS-CRP and JADAS-ESR correlate closely, show similar test characteristics and are feasible and valid tools for assessing disease activity in JIA.

Nordal EB; Zak M; Aalto K; Berntson L; Fasth A; Herlin T; Lahdenne P; Nielsen S; Peltoniemi S; Straume B; Rygg M

2012-07-01

275

Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma  

Science.gov (United States)

Extracting maximal information from gene signature sets (GSSs) via microarray-based transcriptional profiling involves assigning function to up and down regulated genes. Here we present a novel sample scoring method called Signature-score (S-score) which can be used to quantify the expression pattern of tumor samples from previously identified gene signature sets. A simulation result demonstrated an improved accuracy and robustness by S-score method comparing with other scoring methods. By applying the S-score method to cholangiocarcinoma (CAC), an aggressive hepatic cancer that arises from bile ducts cells, we identified enriched oncogenic pathways in two large CAC data sets. Thirteen pathways were enriched in CAC compared with normal liver and bile duct. Moreover, using S-score, we were able to dissect correlations between CAC-associated oncogenic pathways and Gene Ontology function. Two major oncogenic clusters and associated functions were identified. Cluster 1, which included beta-catenin and Ras, showed a positive correlation with the cell cycle, while cluster 2, which included TGF-beta, cytokeratin 19 and EpCAM was inversely correlated with immune function. We also used S-score to identify pathways that are differentially expressed in CAC and hepatocellular carcinoma (HCC), the more common subtype of liver cancer. Our results demonstrate the utility and effectiveness of S-score in assigning functional roles to tumor-associated gene signature sets and in identifying potential therapeutic targets for specific liver cancer subtypes.

Hsiao, Tzu-Hung; Chen, Hung-I Harry; Lu, Jo-Yang; Lin, Pei-Ying; Keller, Charles; Comerford, Sarah; Tomlinson, Gail E.; Chen, Yidong

2013-01-01

276

Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma.  

UK PubMed Central (United Kingdom)

Extracting maximal information from gene signature sets (GSSs) via microarray-based transcriptional profiling involves assigning function to up and down regulated genes. Here we present a novel sample scoring method called Signature-score (S-score) which can be used to quantify the expression pattern of tumor samples from previously identified gene signature sets. A simulation result demonstrated an improved accuracy and robustness by S-score method comparing with other scoring methods. By applying the S-score method to cholangiocarcinoma (CAC), an aggressive hepatic cancer that arises from bile ducts cells, we identified enriched oncogenic pathways in two large CAC data sets. Thirteen pathways were enriched in CAC compared with normal liver and bile duct. Moreover, using S-score, we were able to dissect correlations between CAC-associated oncogenic pathways and Gene Ontology function. Two major oncogenic clusters and associated functions were identified. Cluster 1, which included beta-catenin and Ras, showed a positive correlation with the cell cycle, while cluster 2, which included TGF-beta, cytokeratin 19 and EpCAM was inversely correlated with immune function. We also used S-score to identify pathways that are differentially expressed in CAC and hepatocellular carcinoma (HCC), the more common subtype of liver cancer. Our results demonstrate the utility and effectiveness of S-score in assigning functional roles to tumor-associated gene signature sets and in identifying potential therapeutic targets for specific liver cancer subtypes.

Hsiao TH; Chen HI; Lu JY; Lin PY; Keller C; Comerford S; Tomlinson GE; Chen Y

2013-02-01

277

CCS site characterisation criteria  

Energy Technology Data Exchange (ETDEWEB)

IEA GHG recently commissioned the Alberta Research Counil in Canada to conduct a review of storage site selection criteria and site characterisation methods in order to produce a synthesis report. This report reviews the literature on the subject on the site seleciton and characterisation since the publication of the IPCC Special Report on CCS, and provides a synthesis and classification of criteria. 161 refs.

Bachu, S.; Hawkes, C.; Lawton, D.; Pooladi-Darvish, M.; Perkins, E.

2009-12-15

278

Addiction Severity Index (ASI) summary scores: Comparison of the Recent Status Scores of the ASI-6 and the Composite Scores of the ASI-5.  

Science.gov (United States)

The characteristics and the validity of the Recent Status Scores (RSSs), the new summary scores generated by the sixth version of the Addiction Severity Index (ASI-6), are compared to the fifth version of the ASI summary scores, the Composite Scores (CSs). A sample of 82 randomly selected patients from substance abuse treatment programs were interviewed with the ASI-6, the ASI-5 and were administered a validity battery of questionnaires that included measures corresponding to each of the ASI domains. Each ASI-6 RSS was significantly correlated with its corresponding ASI-5 CS. The intercorrelations among the RSSs are low and none of these correlations were statistically different from the intercorrelations among CSs. In five of the seven areas, the ASI-6 RSSs were more highly correlated to the corresponding validity measures than were the ASI-5 CSs. The ASI-6 offers more comprehensive content in its scales than do those derived with earlier ASIs. PMID:23886822

Denis, Cécile M; Cacciola, John S; Alterman, Arthur I

2013-07-23

279

Addiction Severity Index (ASI) summary scores: Comparison of the Recent Status Scores of the ASI-6 and the Composite Scores of the ASI-5.  

UK PubMed Central (United Kingdom)

The characteristics and the validity of the Recent Status Scores (RSSs), the new summary scores generated by the sixth version of the Addiction Severity Index (ASI-6), are compared to the fifth version of the ASI summary scores, the Composite Scores (CSs). A sample of 82 randomly selected patients from substance abuse treatment programs were interviewed with the ASI-6, the ASI-5 and were administered a validity battery of questionnaires that included measures corresponding to each of the ASI domains. Each ASI-6 RSS was significantly correlated with its corresponding ASI-5 CS. The intercorrelations among the RSSs are low and none of these correlations were statistically different from the intercorrelations among CSs. In five of the seven areas, the ASI-6 RSSs were more highly correlated to the corresponding validity measures than were the ASI-5 CSs. The ASI-6 offers more comprehensive content in its scales than do those derived with earlier ASIs.

Denis CM; Cacciola JS; Alterman AI

2013-11-01

280

Relationship between Machiavellianism scores and performance of real estate salespersons.  

Science.gov (United States)

Data from two samples (ns=37 and 35) of real estate agents showed a significant positive correlation of .37 between Machiavellianism (Mach-B scores) and self-reported sales volume. Present findings support earlier results from samples of stockbrokers and automobile salespersons showing Mach-B scores to be positively related to sales performance. PMID:15825935

Aziz, Abdul

2005-02-01

 
 
 
 
281

Relationship between Machiavellianism scores and performance of real estate salespersons.  

UK PubMed Central (United Kingdom)

Data from two samples (ns=37 and 35) of real estate agents showed a significant positive correlation of .37 between Machiavellianism (Mach-B scores) and self-reported sales volume. Present findings support earlier results from samples of stockbrokers and automobile salespersons showing Mach-B scores to be positively related to sales performance.

Aziz A

2005-02-01

282

Longitudinal Factor Score Estimation Using the Kalman Filter.  

Science.gov (United States)

How longitudinal factor score estimation--the estimation of the evolution of factor scores for individual examinees over time--can profit from the Kalman filter technique is described. The Kalman estimates change more cautiously over time, have lower estimation error variances, and reproduce the LISREL program latent state correlations more…

Oud, Johan H.; And Others

1990-01-01

283

Agreement in the scoring of respiratory events and sleep among international sleep centers.  

UK PubMed Central (United Kingdom)

STUDY OBJECTIVES: The American Academy of Sleep Medicine (AASM) guidelines for polysomnography (PSG) scoring are increasingly being adopted worldwide, but the agreement among international centers in scoring respiratory events and sleep stages using these guidelines is unknown. We sought to determine the interrater agreement of PSG scoring among international sleep centers. DESIGN: Prospective study of interrater agreement of PSG scoring. SETTING: Nine center-members of the Sleep Apnea Genetics International Consortium (SAGIC). MEASUREMENTS AND RESULTS: Fifteen previously recorded deidentified PSGs, in European Data Format, were scored by an experienced technologist at each site after they were imported into the locally used analysis software. Each 30-sec epoch was manually scored for sleep stage, arousals, apneas, and hypopneas using the AASM recommended criteria. The computer-derived oxygen desaturation index (ODI) was also recorded. The primary outcome for analysis was the intraclass correlation coefficient (ICC) of the apnea-hypopnea index (AHI). The ICCs of the respiratory variables were: AHI = 0.95 (95% confidence interval: 0.91-0.98), total apneas = 0.77 (0.56-0.87), total hypopneas = 0.80 (0.66-0.91), and ODI = 0.97 (0.93-0.99). The kappa statistics for sleep stages were: wake = 0.78 (0.77-0.79), nonrapid eye movement = 0.77 (0.76-0.78), N1 = 0.31 (0.30-0.32), N2 = 0.60 (0.59-0.61), N3 = 0.67 (0.65-0.69), and rapid eye movement = 0.78 (0.77-0.79). The ICC of the arousal index was 0.68 (0.50-0.85). CONCLUSION: There is strong agreement in the scoring of respiratory events among the SAGIC centers. There is also substantial epoch-by-epoch agreement in scoring sleep variables. Our results suggest that centralized scoring of PSGs may not be necessary in future research collaboration among international sites where experienced, well-trained scorers are involved.

Magalang UJ; Chen NH; Cistulli PA; Fedson AC; Gíslason T; Hillman D; Penzel T; Tamisier R; Tufik S; Phillips G; Pack AI

2013-04-01

284

Optical syntactic pattern recognition by fuzzy scoring  

Energy Technology Data Exchange (ETDEWEB)

A novel syntactic approach is introduced to treat particular problems in pattern recognition. The procedure is implemented by the use of optical correlation methods for identifying the various primitives that appear in the input pattern, and their importance is determined by fuzzy relational scoring. Robust pattern recognition with tolerance to normal variations is demonstrated, indicating an efficient new approach for optical pattern recognition. {copyright} {ital 1996 Optical Society of America.}

Srinivasan, R.; Kinser, J.; Schamschula, M.; Shamir, J.; Caulfield, H.J. [Center for Applied Optical Sciences, Department of Physics, Alabama A& M University, Normal, Alabama 35762 (United States)

1996-06-01

285

Criteria for the diagnosis of corticobasal degeneration.  

UK PubMed Central (United Kingdom)

Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations. An international consortium of behavioral neurology, neuropsychology, and movement disorders specialists developed new criteria based on consensus and a systematic literature review. Clinical diagnoses (early or late) were identified for 267 nonoverlapping pathologically confirmed CBD cases from published reports and brain banks. Combined with consensus, 4 CBD phenotypes emerged: corticobasal syndrome (CBS), frontal behavioral-spatial syndrome (FBS), nonfluent/agrammatic variant of primary progressive aphasia (naPPA), and progressive supranuclear palsy syndrome (PSPS). Clinical features of CBD cases were extracted from descriptions of 209 brain bank and published patients, providing a comprehensive description of CBD and correcting common misconceptions. Clinical CBD phenotypes and features were combined to create 2 sets of criteria: more specific clinical research criteria for probable CBD and broader criteria for possible CBD that are more inclusive but have a higher chance to detect other tau-based pathologies. Probable CBD criteria require insidious onset and gradual progression for at least 1 year, age at onset ? 50 years, no similar family history or known tau mutations, and a clinical phenotype of probable CBS or either FBS or naPPA with at least 1 CBS feature. The possible CBD category uses similar criteria but has no restrictions on age or family history, allows tau mutations, permits less rigorous phenotype fulfillment, and includes a PSPS phenotype. Future validation and refinement of the proposed criteria are needed.

Armstrong MJ; Litvan I; Lang AE; Bak TH; Bhatia KP; Borroni B; Boxer AL; Dickson DW; Grossman M; Hallett M; Josephs KA; Kertesz A; Lee SE; Miller BL; Reich SG; Riley DE; Tolosa E; Tröster AI; Vidailhet M; Weiner WJ

2013-01-01

286

Control performance criteria  

Energy Technology Data Exchange (ETDEWEB)

Control performance has been measured in the utility industry by the A1 and A2 control performance criteria. The use of A1 and A2 has resulted in years of reliable operation. However, the heuristic, arbitrary nature of A1 and A2 has prompted the utility industry to search for a technically defensible control performance criteria. This paper reviews the role of interconnection frequency and inadvertent energy in reliable interconnection operation. The role of control performance criteria and Area Control Error (ACE) is explained. An alternative control performance standard is presented. The differences between A1 and A2 and the new control performance standard are discussed.

Hoffman, S.P.; Illian, H. [ComEd, Lombard, IL (United States). Bulk Power Operations

1996-11-01

287

Fire protection design criteria  

Energy Technology Data Exchange (ETDEWEB)

This Standard provides supplemental fire protection guidance applicable to the design and construction of DOE facilities and site features (such as water distribution systems) that are also provided for fire protection. It is intended to be used in conjunction with the applicable building code, national Fire Protection Association Codes and Standards, and any other applicable DOE construction criteria. This Standard, along with other delineated criteria, constitutes the basic criteria for satisfying DOE fire and life safety objectives for the design and construction or renovation of DOE facilities.

NONE

1997-03-01

288

The Birmingham Epidermolysis Bullosa Severity score: development and validation.  

UK PubMed Central (United Kingdom)

BACKGROUND: Objective severity scores facilitate clinical care and research. However, the rarity and heterogeneity of epidermolysis bullosa (EB) make scoring difficult. OBJECTIVES: To develop a severity score covering all subtypes of EB at all ages that is simple, valid, sensitive and reliable. METHODS: Score items and weightings were generated by expert consensus, and refined for content and face validity. The Birmingham EB Severity (BEBS) score was tested on 97 patients aged 0-64 years. RESULTS: Eleven items were scored: area of damaged skin, involvement of nails, mouth, eyes, larynx and oesophagus, scarring of hands, skin cancer, chronic wounds, alopecia and nutritional compromise. Area was allocated 50 points, and the 10 other items 5 points each, giving a maximum score of 100. Lowest BEBS scores occurred in Weber-Cockayne EB simplex (median 1.0; range 0.1-3.0; n = 12), highest scores in generalized non-Herlitz junctional EB (28.5; 5.0-62.0; n = 7), Hallopeau-Siemens recessive dystrophic EB (HS-RDEB) (22.9; 4.3-69.0; n = 23) and Herlitz junctional EB (H-JEB) (14.4; 2.5-49.3; n = 9), and intermediate scores in dominant dystrophic EB (5.3; 0.5-15.9; n = 19), Dowling-Meara EB simplex (DM-EBS) (6.3; 2.8-22.5; n = 16) and non-Hallopeau-Siemens recessive dystrophic EB (7.8, 2.8-27.8; n = 11). Intra- and interobserver correlations were high. With age, scores increased for H-JEB (r = 0.9, P = 0.001) and HS-RDEB (r = 0.73, P = 0.001) and decreased for DM-EBS (r = -0.62, P = 0.01), with positive but nonsignificant correlations for the other types. CONCLUSIONS: The BEBS score appears valid and reproducible, gives appropriate scores for different subtypes, and reflects changes with age.

Moss C; Wong A; Davies P

2009-05-01

289

Classification criteria for spondyloarthropathies  

Directory of Open Access Journals (Sweden)

Full Text Available Spondyloarthropathies (SpA) are a group of inflammatory arthritis which consist of ankylosing spondylitis (AS), reactive arthritis, arthritis/spondylitis associated with psoriasis (PsA), and arthritis/spondylitis associated with inflammatory bowel diseases. It is now more important than ever to diagnose and treat SpA early. New therapeutic agents including blockers of tumor necrosis factor have yielded tremendous responses not only in advanced disease but also in the early stages of the disease. Sacroiliitis on conventional radiography is the result of structural changes which may appear late in the disease process. However, magnetic resonance imaging (MRI) can visualize active inflammation at sacroiliac joints and spine in recent onset disease. The modified New York criteria, the European Spondyloarthropathy Study Group criteria and the Amor criteria do not include advanced imaging techniques like MRI which is very sensitive to the early Inflammatory changes. Assessment of SpondyloArthritis international Society has defined MRI methods for the assessment of sacroiliac joints and spine, criteria for inflammatory back pain and developed new criteria for classification of axial and peripheral spondyloarthritis. These new criteria are intended to be used for patients with SpA at the very early stage of their disease. Also, classification of psoriatic arthritis study group developed criteria for the classification of PsA. The widespread use of these criteria in clinical trials will provide evidence for a better definition of early disease and recognize many patients who may further develop classical AS or PsA. These efforts will guide therapeutic trials of potent drugs like biological agents in the early stage of these diseases.

Ozgur Akgul; Salih Ozgocmen

2011-01-01

290

Whole-Organ Arthroscopic Knee Score (WOAKS)  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background To describe a semi-quantitative score for multi-feature, whole-organ evaluation of the knee in osteoarthritis based on the results of arthroscopic evaluation. Methods This was a study of 1,199 patients who were suffering from knee pain for over 3 months (range 3 to 48 months) and had undergone arthroscopy. The mean age of patients was 49.8 (range 17 to 85) years old. Cartilage lesions were graded according to the ICRS protocol (grade 0 to 4 and for osteophytes "grade 5"). Meniscus lesions were classified regarding to the extent of resection which was needed (grade 0: intact meniscus, grade 1: partial meniscectomy, grade 2: subtotal meniscectomy, and grade 3: total meniscectomy). The whole grade of cartilage lesions was calculated as the sum of ICRS grades in all joint surfaces (bearing and non-bearing margin). The whole grade of meniscus lesions was calculated as the sum of the points for medial and lateral meniscus surgery. The Whole-Organ Arthroscopic Knee Score (WOAKS) was the sum of the cartilage and meniscus score. Results The mean knee osteoarthritis outcome score (KOOS) of all patients was 67.3 ± 26.0 (range 21 to 128) points. The WOAKS was significantly associated (p = 0.001) with patient age (R = 0.399), the subjective complaints (R = 0.630) in KOOS, and the radiological grade of OA (R = 0.731). Conclusion The good correlation between the WOAKS and the subjective complaints as well as the radiological grade of OA suggests that the score can be used as an instrument for description of the "whole organ" knee. This score may be useful for clinical or epidemiological studies in the future.

Spahn Gunter; Mückley Thomas; Klinger Hans M; Hofmann Gunther O

2008-01-01

291

Major salivary gland sonography in Sjogren's syndrome: diagnostic value of a novel ultrasonography score (0-12) for parenchymal inhomogeneity.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To validate ultrasonographic criteria for examination of the major salivary glands in the diagnosis of primary Sjögren's syndrome (SS). METHOD: A total of 209 consecutive patients with rheumatic diseases were selected according to the American-European Consensus Group (AECG) classification criteria for SS. One hundred and fifteen patients had primary SS, 44 had secondary SS, and 50 had sicca symptoms, and 36 subjects served as asymptomatic controls. This cohort was analysed for size, echogenicity, parenchymal inhomogeneity, focal changes, and posterior borders of the major salivary glands by ultrasonography (US). A novel US score for parenchymal inhomogeneity (0-12) was assigned and its diagnostic accuracy evaluated. RESULTS: Ultrasonographic abnormalities of salivary glands were detected in 107/115 (93.0%) patients with primary SS, in 12/44 (27.3%) with secondary SS, in 25/50 (50.0%) with sicca symptoms, and in 4/36 (11.1%) asymptomatic controls. Area under the receiver operating characteristic curve (AUC-ROC) for US inhomogeneity score was highly significant [0.96 +/- 0.01; 95% confidence interval (CI) 0.94-0.99, p < 0.000] for primary SS, with a sensitivity to specificity ratio of 91/83 for parotid and 93/90 for submandibular glands. Setting the cut-off US inhomogeneity score at 6 resulted in the best ratio of specificity (90.0%) to sensitivity (95.1%), with a positive predictive value of 72% and a negative predictive value of 96%. A US inhomogeneity score >or= 6 was closely correlated with positive biopsy (p < 0.000) and scintigraphy findings (p < 0.000). CONCLUSIONS: We demonstrate the high diagnostic value of a novel US score for parenchymal inhomogeneity (0-12) that could serve as a useful single US criterion in the evaluation of salivary gland involvement in primary SS.

Milic VD; Petrovic RR; Boricic IV; Radunovic GL; Pejnovic NN; Soldatovic I; Damjanov NS

2010-03-01

292

Jeopardised Inferior Myocardium (JIM) score: an arithmetic electrocardiographic score to predict the infarct-related artery in inferior myocardial infarction.  

UK PubMed Central (United Kingdom)

INTRODUCTION: A few electrocardiographic criteria have been described to identify the infarct-related artery in inferior myocardial infarction. The aim of this study was to devise an arithmetic score to further improve the diagnostic accuracy. MATERIALS AND METHODS: From 2004 to 2006, 78 patients who underwent primary angioplasty for inferior myocardial infarction within 6 hours from symptom onset were recruited for electrocardiographic and angiographic analysis. RESULTS: The mean age of patients was 65 ± 12 years with male predominance (74%). Less ST depression in lead I and aVL, and more prominent ST depression in lead V1-3 were observed in left circumflex artery (LCX) than right coronary artery (RCA) occlusions. In addition, more prominent ST depression in lead I and ST elevation in V1 were found in proximal RCA than distal RCA occlusions. Based on the findings, the Jeopardised Inferior Myocardium (JIM) score was constructed and defi ned as [II-V3/III+V1- I]. The sensitivity and specificity of JIM score ?0.5 to predict proximal RCA occlusions; 0.5 score ?1.5 to predict distal RCA occlusions; and JIM score >1.5 to predict LCX occlusions were 58% and 85%, 69% and 68%, and 79% and 94%, respectively. The accuracy of prediction is slightly better than the 2 previously reported criteria. CONCLUSION: By taking into account more leads, the JIM score is capable of identifying the infarct-related artery with an improved diagnostic accuracy.

Jim MH; Tsui KL; Yiu KH; Cheung GS; Siu CW; Ho HH; Chow WH; Li SK

2012-07-01

293

Determining ICH Score: can we go beyond?/ Determinando o ICH Score: podemos ir além?  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A hemorragia intracerebral (AVCH) espontânea ainda apresenta grande heterogeneidade em sua avaliação clínica, evidenciando diferenças nos critérios de inclusão utilizados nos estudos de tratamento da hemorragia intracerebral (ICH). O objetivo do presente estudo foi avaliar o ICH Score, uma escala simples e confiável, determinando a mortalidade em 30 dias e o resultado funcional após um ano. Pacientes consecutivos com AVCH espontâneo foram incluídos prospectivam (more) ente no estudo. O ICH Score variou de 0 a 4 e cada aumento no ICH Score esteve associado com um aumento na mortalidade em 30 dias e com uma progressiva diminuição nas taxas de bom resultado funcional. Entretanto, a ocorrência de injúria da via piramidal esteve melhor relacionada com um pior resultado funcional do que o ICH Score. O ICH Score é um bom preditor de mortalidade em 30 dias e resultado funcional, confirmando sua validade em diferentes populações socioeconômicas. A associação da injúria da via piramidal como variável auxiliar fornece informações mais precisas sobre a evolução prognóstica. Abstract in english Spontaneous intracerebral hemorrhage (SICH) still presents a great heterogeneity in its clinical evaluation, demonstrating differences in the enrollment criteria used for the study of intracerebral hemorrhage (ICH) treatment. The aim of the current study was to assess the ICH Score, a simple and reliable scale, determining the 30-day mortality and the one-year functional outcome. Consecutive patients admitted with acute SICH were prospectively included in the study. ICH S (more) cores ranged from 0 to 4, and each increase in the ICH Score was associated with an increase in the 30-day mortality and with a progressive decrease in good functional outcome rates. However, the occurrence of a pyramidal pathway injury was better related to worse functional outcome than the ICH Score. The ICH Score is a good predictor of 30-day mortality and functional outcome, confirming its validity in a different socioeconomic populations. The association of the pyramidal pathway injury as an auxiliary variable provides more accurate information about the prognostic evolution.

Patriota, Gustavo Cartaxo; Silva-Júnior, João Manoel da; Barcellos, Alécio Cristino Evangelista Santos; Silva Júnior, Joaquim Barbosa de Sousa; Toledo, Diogo Oliveira; Pinto, Fernando Campos Gomes; Rotta, José Marcus

2009-09-01

294

D-score: a search engine independent MD-score.  

Science.gov (United States)

While peptides carrying PTMs are routinely identified in gel-free MS, the localization of the PTMs onto the peptide sequences remains challenging. Search engine scores of secondary peptide matches have been used in different approaches in order to infer the quality of site inference, by penalizing the localization whenever the search engine similarly scored two candidate peptides with different site assignments. In the present work, we show how the estimation of posterior error probabilities for peptide candidates allows the estimation of a PTM score called the D-score, for multiple search engine studies. We demonstrate the applicability of this score to three popular search engines: Mascot, OMSSA, and X!Tandem, and evaluate its performance using an already published high resolution data set of synthetic phosphopeptides. For those peptides with phosphorylation site inference uncertainty, the number of spectrum matches with correctly localized phosphorylation increased by up to 25.7% when compared to using Mascot alone, although the actual increase depended on the fragmentation method used. Since this method relies only on search engine scores, it can be readily applied to the scoring of the localization of virtually any modification at no additional experimental or in silico cost. PMID:23307401

Vaudel, Marc; Breiter, Daniela; Beck, Florian; Rahnenführer, Jörg; Martens, Lennart; Zahedi, René P

2013-02-15

295

Remediation of low ABSITE scores.  

UK PubMed Central (United Kingdom)

PURPOSE: In 2000, a program was initiated to improve American Board of Surgery In-Training Exam (ABSITE) scores below the 40th percentile (PGY-1 and -2) and the 30th percentile (PGY-3 and -5) for categorical residents. The goal of this program is to maintain scores above this standard. METHODS: One faculty member was designated to meet with each resident with ABSITE scores below the standard described above. In April, individual study plans were designed with each resident, which emphasized practice questions and strategic planning for study, and the ABSITE test structure and results were reviewed. Two subsequent meetings were held between November and December to monitor progress. Emphasis was placed on minimizing the stigma of poor scores and on maximizing the efficiency of study time. If the resident scored above-standard that year, further support was not required. RESULTS: From 2000 to 2004, 12 (9.5%) ABSITE scores were below-standard, which resulted in 8 (20.5%) residents receiving program support 9 times. All but 1 program encounter resulted in above-standard scores the following year (improvement range, 16 to 65 percentile points; average, 34 points). Two residents had recurrent below-standard scores in subsequent years despite above-standard scores immediately after the program. One resident did not participate in the program, despite it being designated as mandatory. During the same interval, the ABSITE scores of residents not involved in the program decreased by an average of 3.7 percentile points per examination (improved scores 31 times; 39.2%, range 1 to 46, average 13.5, worse scores 45 times; 57%, range 1 to 65, average 15.2, and no change 3 times, 3.8%). CONCLUSIONS: An individualized program that minimizes the stigma of poor test results, the time commitment required by the residents, and maximizes the benefits of a question-based study system and the knowledge of approach to the ABSITE resulted in significant improvements in scores the next year. However, maintenance of these results needs continued evaluation because 3 residents had recurrent poor scores in subsequent years.

Harthun NL; Schirmer BD; Sanfey H

2005-09-01

296

Transport Disposition Using Transport Risk Assessment in Pediatrics (TRAP) Score  

Science.gov (United States)

Background Determining appropriate disposition for referred pediatric patients is difficult since it relies primarily on a telephone description of the patient. In this study, we evaluate the Transport Risk Assessment in Pediatrics (TRAP) score’s ability to assist in appropriate placement of these patients. This novel tool is derived from physiologic variables. Objectives To determine the feasibility of calculating a TRAP score and whether a higher score correlates with Pediatric Intensive Care Unit (PICU) admission. Methods We performed an observational study of pediatric patients transported by a specialized team to a tertiary care center and the feasibility of implementing the TRAP tool. Patients were eligible if transported by the pediatric specialty transport team for direct admission to the children’s hospital. The TRAP score was obtained either through chart review of transport team’s initial assessment or real-team by the transport team. Results A total of 269 patients were identified with 238 patients included in the study Using logistic regression, higher TRAP scores were associated with PICU admission (OR 1.40, p <0.001). Patients with a higher score were also less likely to leave the PICU within 24 hours (OR 0.79, p <0.001). Conclusion The TRAP score is a novel objective pediatric transport assessment tool where an elevated score is associated with PICU admission for greater than 24 hours. This score may assist with the triage decisions for transported pediatric patients.

Kandil, Sarah B.; Sanford, Heather A. (Schmenk); Northrup, Veronika; Bigham, Michael Theodore; Giuliano, John Sebastian

2012-01-01

297

Comparing directly measured standard gamble scores to HUI2 and HUI3 utility scores: group- and individual-level comparisons.  

Science.gov (United States)

Directly measured standard gamble (SG) utility scores reflect the respondent's assessment and valuation of their own health status. Scores from the health utilities index (HUI) are based on self-assessed health status but valued using community preferences obtained using the SG. Our objectives were to find if mean directly measured utility scores agree with mean HUI mark 2 (HUI2) and mean HUI mark 3 (HUI3) scores. Also, if individual directly measured utility scores agree with HUI2 and HUI3 scores, and whether HUI2 and HUI3 scores agree. Questionnaires based on the HUI2 and HUI3 health-status classification systems were administered by interviewers to 140 teenage survivors of extremely low birthweight (ELBW) and 124 control group teens. Respondents were asked to think about their own usual health states using six dimensions from HUI2 and value that state using the SG. Mean SG scores are compared with mean HUI2 and mean HUI3 scores using paired sample t-tests. Mean HUI2 scores are compared with mean HUI3 scores. Agreement among scores is assessed using intra-class correlation coefficient (ICC). The effect of severity of health-state morbidity on agreement was assessed using three approaches. ELBW cohort mean (standard deviation) SG, HUI2, and HUI3 scores were 0.90 (0.20), 0.89 (0.14), and 0.80 (0.22). Results for controls were 0.93 (0.11), 0.95 (0.09), and 0.89 (0.13). Mean SG and HUI2 scores did not differ; mean SG and HUI3 did differ; mean HUI2 and HUI3 also differed. At the individual level for ELBW, the ICCs between SG and HUI2, SG and HUI3, and HUI2 and HUI3 scores were 0.13, 0.28, and 0.64. For controls the ICCs were 0.14, 0.24, and 0.56. HUI2 scores appear to match directly measured utility scores reasonably well at the group level. HUI2 and HUI3 scores differ systematically. At the individual level, however, HUI2 and HUI3 scores are poor substitutes for directly measured scores. PMID:14672594

Feeny, David; Furlong, William; Saigal, Saroj; Sun, Jian

2004-02-01

298

Intussusception in infancy and childhood: evaluation of a prognostic scoring pattern.  

Directory of Open Access Journals (Sweden)

Full Text Available This is a retrospective analysis of 82 patients of intussusception in infancy and childhood. Males were more than females in the ratio 2.4 : 1, the ages varied from 2 months to 12 years. Majority (73%) were less than 1 year old. Commonest presentations were pain, vomiting, distension, palpable lump and blood and mucus in stools. The management of these patients varied from barium enema reduction (3 cases), reduction by surgery and manipulation (59 cases) and resection with primary anastomosis (20 cases). We analysed our patients by giving scores based on clinical criteria. We concluded that the patients in our circumstances do not show any correlation of the scoring pattern with morbidity or mortality, chances of reduction by barium enema or manually. Resection, however, did correlate with a high incidence of death (75%). Resections were required slightly more in ileo-ileal intussusceptions than in those having a colonic involvement, morbidity in the form of wound dehiscence, and sepsis was higher in those patients who had undergone resections.

Rege V; Deshmukh S; Borwankar S; Kulkarni B

1991-01-01

299

Comparing Scoring and Fuzzy Logic Method for Teacher Certification DSS in Indonesia  

Directory of Open Access Journals (Sweden)

Full Text Available Graduation of teacher certification participants plays an important role in improving the quality of education in Indonesia. This paper presents a decision support system using a Scoring and Fuzzy Logic method to determine the participants graduation of teacher certification based on requirements fulfilled. Five criteria were used as the input of the system. In Fuzzy Logic method, each criteria is divided into three parts: low, medium and high; while scoring method is determined by using a 1 - 5 scale for each requirement fulfilled. Graduation and participants ranking using Scoring and Fuzzy Logic is the output of the system. In this paper, the assessment using Scoring and Fuzzy Logic showed different ranks and results in some scores, particularly in practice assessment by using scoring method for score 64,5 would not graduated the participants since the score of practice assessment is 65. While Fuzzy Logic would observe the scores of the four different methods, if those four criteria in the fuzzy were in high parts, then the participants graduated the tests. This means Fuzzy Logic more equitable to present decision and determine the ranks. In this paper was successful comparing Scoring and Fuzzy Logic method.

Ida Ayu Purnama Dewi; A.A. Kompiang Oka Sudana, S.Kom, Mt; Dr. I Ketut Gede Darma Putra, S.Kom. Mt

2012-01-01

300

Summarized water quality criteria  

International Nuclear Information System (INIS)

[en] The available world literature from 27 sources on existing water quality criteria are summarized for the 15 main uses of water. The minimum, median and maximum specified values for 96 different determinands are included. Under each water use the criteria are grouped according to the functional significance of the determinands e.g. aesthetic/physical effects, high toxic potential, low toxic potential etc. A synopsis is included summarizing salient facts for each determinand such as the conditions under which it is toxic and its relationship to other determinands. The significance of the criteria is briefly discussed and the importance of considering functional interactions between determinands emphasized in evaluating the potential for toxic or beneficial effects. From the source literature it appears that the toxic potential, in addition to being determined by concentration, is also affected by the origin of the substance concerned, i.e. whether from natural sources or from anthropogenic pollution

1980-01-01

 
 
 
 
301

Remission in early rheumatoid arthritis -- a comparison of new ACR/EULAR remission criteria to established criteria.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To describe the frequency of remission in an early rheumatoid arthritis (ERA) cohort. METHODS: The frequency of remission was evaluated, based on 8 definitions including the Boolean-based American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria. RESULTS: Of 369 patients, remission at 12 months ranged from 18% according to the ACR/EULAR clinical trial criteria to 40% according to the 28-joint Disease Activity Score (DAS28) < 2.6. Higher tender joint count, swollen joint count, and physician global scores were seen for DAS28-based definitions, and patient global assessment (PtGA) scores were almost 5-fold higher for DAS28 remission. CONCLUSION: Remission is achievable in ERA but its frequency differs according to the remission definition applied. Adoption of the new ACR/EULAR definition will limit the number classified as in remission, especially if the PtGA criteria are rated high for reasons other than inflammatory arthritis.

Kuriya B; Sun Y; Boire G; Haraoui B; Hitchon C; Pope JE; Thorne JC; Keystone EC; Bykerk VP

2012-06-01

302

Metabolic syndrome, adiponectin, and cardiovascular risk in Spain (the segovia study): impact of consensus societies criteria.  

UK PubMed Central (United Kingdom)

Abstract Background: We aimed to investigate the prevalence of metabolic syndrome in rural and urban areas in the province of Segovia, Spain, and its relationship to lifestyle habits, cardiovascular risk, and serum adiponectin concentrations. Methods: The study had a cross-sectional design and included 888 individual residents in the province of Segovia, Autonomous Community of Castilla-León. Results: The age/sex standardized prevalence of the metabolic syndrome was by: (1) American Heart Association/National Heart Lung and Blood Institute criteria (AHA/NHLBI), 17%; (2) International Diabetes Federation (IDF), 24.3%; and (3) Consensus Societies/Joint Interim Statement (CS), 27.8%. A high correlation was found between the different criteria. No formal education [odds ratio (OR) 6.9 (2.4-20.2)] and primary education [6.7 (2.8-15.9)] were independently associated with metabolic syndrome. An inverse association with metabolic syndrome was found for subjects doing a high level of exercise during work [0.4 (0.2-0.7)] as well as those who were mild drinkers [alcohol intake of less than 15 grams/daily, 0.4 (0.3-0.8)]. Among subjects with low estimated cardiovascular risk, adiponectin levels are higher in those who do not meet criteria of metabolic syndrome. A total of 29.7% of subjects meeting CS criteria had >20% 10-year predicted risk of cardiovascular disease (CVD) by the Framingham risk score criteria [4.5 (2.4-8.5)]. Conclusions: Our results show: (1) A higher estimated prevalence of metabolic syndrome according to IDF and CS criteria. (2) Low educational level was independently associated with metabolic syndrome. A high level of physical activity and a daily alcohol intake of less than 15 grams/day were inversely associated with metabolic syndrome. (3) Metabolic syndrome increases the predicted CVD risk. (4) Adiponectin levels are not inversely related to insulin resistance in subjects with high cardiovascular risk and metabolic syndrome.

Corbatón-Anchuelo A; Martínez-Larrad MT; Fernández-Pérez C; Vega-Quiroga S; Ibarra-Rueda JM; Serrano-Ríos For The Segovia Insulin Resistance Study Group M

2013-10-01

303

Urinary PCA3 score predicts prostate cancer multifocality.  

UK PubMed Central (United Kingdom)

PURPOSE: The urinary PCA3 gene test has proved helpful for deciding whether to (re)biopsy to diagnose prostate cancer. We searched for pathological features that influence the shedding of PCA3 producing prostate cancer cells in urine after digital rectal examination. MATERIALS AND METHODS: Included in our study were 102 patients with an informative PCA3 score on the Progensa® PCA3 assay who underwent radical prostatectomy. Correlations were evaluated between PCA3 score and histopathological factors on prostatectomy, including tumor site in the prostate and the number of cancer foci. RESULTS: PCA3 score significantly correlated with total tumor volume in prostatectomy specimens (p <0.001) but not with prostatectomy Gleason score or pathological stage. PCA3 score positively correlated with apical and basal invasion, and with bilaterality and multifocality. On multivariate analysis multifocality was an independent factor influencing PCA3 score (p = 0.012). CONCLUSIONS: Site in the prostate gland and the number of cancer foci may explain the observed PCA3 score variation in patients operated on for prostate cancer. The PCA3 test could be helpful in preoperatively selecting patients with unifocal and unilateral cancer who could benefit from active surveillance or focal therapy.

Vlaeminck-Guillem V; Devonec M; Colombel M; Rodriguez-Lafrasse C; Decaussin-Petrucci M; Ruffion A

2011-04-01

304

Flame temperature criteria tests  

International Nuclear Information System (INIS)

Since the Lewis-Karlovitz flame temperature criteria had been based on data obtained from hydrogen flammability tests using hydrogen-air mixtures at room temperature and atmospheric pressure, a test program was conducted at Fenwal Incorporated to evaluate its applicability to a post-accident containment atmosphere at elevated temperature and pressure. Another objective of this test program was to obtain laminar burning velocities under post-accident containment atmospheric conditions. These velocities are needed for estimating the hydrogen burn time in containments. This paper presents the results obtained from this test program, which are then used to validate the Lewis-Karlovitz flame temperature criteria

1982-01-01

305

Development of a software tool and criteria evaluation for efficient design of small interfering RNA.  

UK PubMed Central (United Kingdom)

RNA interference can be used as a tool for gene silencing mediated by small interfering RNAs (siRNA). The critical step in effective and specific RNAi processing is the selection of suitable constructs. Major design criteria, i.e., Reynolds's design rules, thermodynamic stability, internal repeats, immunostimulatory motifs were emphasized and implemented in the siRNA design tool. The tool provides thermodynamic stability score, GC content and a total score based on other design criteria in the output. The viability of the tool was established with different datasets. In general, the siRNA constructs produced by the tool had better thermodynamic score and positional properties. Comparable thermodynamic scores and better total scores were observed with the existing tools. Moreover, the results generated had comparable off-target silencing effect. Criteria evaluations with additional criteria were achieved in WEKA.

Chaudhary A; Srivastava S; Garg S

2011-01-01

306

[Usefulness of a predictive score in subarachnoid hemorrhage diagnosis].  

UK PubMed Central (United Kingdom)

Usefulness of a predictive score in subarachnoid hemorrhage diagnosis Nearly half of the patients with non-traumatic subarachnoid hemorrhage (SAH) present with no neurological signs, inducing clinical underestimation of the gravity of their affection. As the outcome of aneurismal SAH is highly dependant on the initial neurological status and the recurrence of untreated hemorrhagic events, these neurologically intact patients stand to suffer the most from delayed diagnosis. Although there is currently no validated predictive score that reliably identifies SAH-induced headache, a combination of clinical criteria derived from a cohort of sudden-onset headache patients should allow risk stratification and identification of those patients requiring further investigation.

Clerc D; Rutz P; Hugli O

2011-08-01

307

Morphological quantitative criteria and aesthetic evaluation of eight female Han face types.  

UK PubMed Central (United Kingdom)

BACKGROUND: Human facial aesthetics relies on the classification of facial features and standards of attractiveness. However, there are no widely accepted quantitative criteria for facial attractiveness, particularly for Chinese Han faces. Establishing quantitative standards of attractiveness for facial landmarks within facial types is important for planning outcomes in cosmetic plastic surgery. The aim of this study was to determine quantitatively the criteria for attractiveness of eight female Chinese Han facial types. METHODS: A photographic database of young Chinese Han women's faces was created. Photographed faces (450) were classified based on eight established types and scored for attractiveness. Measurements taken at seven standard facial landmarks and their relative proportions were analyzed for correlations to attractiveness scores. Attractive faces of each type were averaged via an image-morphing algorithm to generate synthetic facial types. Results were compared with the neoclassical ideal and data for Caucasians. RESULTS: Morphological proportions corresponding to the highest attractiveness scores for Chinese Han women differed from the neoclassical ideal. In our population of young, normal, healthy Han women, high attractiveness ratings were given to those with greater temporal width and pogonion-gonion distance, and smaller bizygomatic and bigonial widths. As attractiveness scores increased, the ratio of the temporal to bizygomatic widths increased, and the ratio of the distance between the pogonion and gonion to the bizygomatic width also increased slightly. Among the facial types, the oval and inverted triangular were the most attractive. CONCLUSION: The neoclassical ideal of attractiveness does not apply to Han faces. However, the proportion of faces considered attractive in this population was similar to that of Caucasian populations. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Zhao Q; Zhou R; Zhang X; Sun H; Lu X; Xia D; Song M; Liang Y

2013-04-01

308

STANDARD DESIGN CRITERIA  

Science.gov (United States)

Hanford Atomic Production Operation specification gaides for design criteria, structural engineering, civil engineering, heating, ventilation, air conditioning, fire alarm systems, noise control, lighting, railroad construction, corrosion protection, and electrical engineering are presented. Details of this manual are given in TID-4100 (Suppl.). (N.W.R.)

None

1963-01-01

309

Graphite criteria peer review  

Energy Technology Data Exchange (ETDEWEB)

This report documents a review of the stress criteria proposed for the graphite components of the modular high temperature gas-cooled reactor (MHTGR) core. The review was conducted by a panel of six independent consultants, chosen for their expertise over a range of relevant disciplines.

NONE

1986-09-01

310

Residual radioactivity criteria  

International Nuclear Information System (INIS)

[en] This paper provides an overview of current and future decommissioning standards applicable in the United States. The standards promulgated by both the US Department of Energy (DOE) and the US Nuclear Regulatory Commission (NRC), as well as standards proposed by the American National Standards Institute, are presented. A summary is presented of the recent NRC actions to produce revised residual radioactivity criteria

1992-06-15

311

Evaluation of the POSSUM score in surgical treatment of cholangiocarcinoma.  

UK PubMed Central (United Kingdom)

BACKGROUND/AIMS: The surgical treatment for cholangiocarcinoma (CCC) is still a challenge. The aim of this study was to evaluate the POSSUM scoring system for preoperative physiological risk adjustment and for the operative risk of postoperative morbidity and mortality. METHODOLOGY: The operative notes and hospital files of 171 patients with CCC were analyzed retrospectively. The POSSUM scoring system was used to predict morbidity and mortality rates after surgery. The physiological sub score and the operative sub score of the POSSUM score were analyzed with regard to their ability to predict major postoperative complications. RESULTS: The overall complication rate was 40.9% and the mortality was 11.2%. The morbidity predicted by POSSUM was 63.5% and the prediction for postoperative mortality was 23.7%. Both rates are much higher than the observed morbidity and mortality. High operative severity sub scores correlate with the occurrence of major complications. CONCLUSION: The POSSUM scoring system over predicts morbidity and mortality in surgery for CCC. Operative severity and intraoperative parameters have a greater influence on postoperative mortality and morbidity rates than the physiological parameters represented in the POSSUM physiological score. Prospective studies will have to show whether POSSUM can be modified or whether it is necessary to develop a new score for assessing morbidity and mortality in surgery for CCC.

Hellmann S; Schafmayer C; Hinz S; Schniewind B; Tepel J; Broering DC; Egberts JH

2010-05-01

312

Automated CT scoring of airway diseases: preliminary results.  

UK PubMed Central (United Kingdom)

RATIONALE AND OBJECTIVES: The aim of this study was to retrospectively evaluate an automated global scoring system for evaluating the extent and severity of disease in a known cohort of patients with documented bronchiectasis. On the basis of a combination of validated three-dimensional automated algorithms for bronchial tree extraction and quantitative airway measurements, global scoring combines the evaluation of bronchial lumen-to-artery ratios and bronchial wall-to-artery ratios, as well as the detection of mucoid-impacted airways. The result is an automatically generated global computed tomographic (CT) score designed to simplify and standardize the interpretation of scans in patients with chronic airway infections. MATERIALS AND METHODS: Twenty high-resolution CT data sets were used to evaluate an automated CT scoring method that combines algorithms for airway quantitative analysis that have been individually tested and validated. Patients with clinically documented atypical mycobacterial infections with visually assessed CT evidence of bronchiectasis varying from mild to severe were retrospectively selected. These data sets were evaluated by two independent experienced radiologists and by computer scoring, with the results compared statistically, including Spearman's rank correlation. RESULTS: Computer evaluation required 3 to 5 minutes per data set, compared to 12 to 15 minutes for manual scoring. Initial Spearman's rank tests showed positive correlations between automated and readers' global scores (r = 0.609, P = .01), extent of bronchiectasis (r = 0.69, P = .0004), and severity of bronchiectasis (r = 0.61, P = .01), while mucus plug detection showed a lesser extent of positive correlation between the scoring methods (r = 0.42, P = .07) and wall thickness a negative weak correlation (r = -0.10, P = .40). Further retrospective review of 24 lobes in which wall thickness scores showed the highest discrepancy between manual and automated methods was then performed, using electronic calipers and perpendicular cross-sections to reassess airway measurements. This resulted in an improved Spearman's rank correlation to r = 0.62 (P = .009), for a global score of r = 0.67 (P = .001). CONCLUSION: Automated computerized scoring shows considerable promise for providing a standardized, quantitative method, demonstrating overall good correlation with the results of experienced readers' evaluation of the extent and severity of bronchiectasis. It is speculated that this technique may also be applicable to a wide range of other conditions associated with chronic bronchial inflammation, as well as of potential value for monitoring response to therapy in these same populations.

Odry BL; Kiraly AP; Godoy MC; Ko J; Naidich DP; Novak CL; Lerallut JF

2010-09-01

313

Validation of a novel risk score for severity of illness in acute exacerbations of COPD.  

UK PubMed Central (United Kingdom)

BACKGROUND: Clinicians lack a validated tool for risk stratification in acute exacerbations of COPD (AECOPD). We sought to validate the BAP-65 (elevated BUN, altered mental status, pulse > 109 beats/min, age > 65 years) score for this purpose. METHODS: We analyzed 34,699 admissions to 177 US hospitals (2007) with either a principal diagnosis of AECOPD or acute respiratory failure with a secondary diagnosis of AECOPD. Hospital mortality and need for mechanical ventilation (MV) served as co-primary end points. Length of stay (LOS) and costs represented secondary end points. We assessed the accuracy of BAP-65 via the area under the receiver operating characteristic curve (AUROC). RESULTS: Nearly 4% of subjects died while hospitalized and approximately 9% required MV. Mortality increased with increasing BAP-65 class, ranging from < 1% in subjects in class I (score of 0) to > 25% in those meeting all BAP-65 criteria (Cochran-Armitage trend test z = -38.48, P < .001). The need for MV also increased with escalating score (2% in the lowest risk cohort vs 55% in the highest risk group, Cochran-Armitage trend test z = -58.89, P < .001). The AUROC for BAP-65 for hospital mortality and/or need for MV measured 0.79 (95% CI, 0.78-0.80). The median LOS was 4 days, and mean hospital costs equaled $5,357. These also varied linearly with increasing BAP-65 score. CONCLUSIONS: The BAP-65 system captures severity of illness and represents a simple tool to categorize patients with AECOPD as to their risk for adverse outcomes. BAP-65 also correlates with measures of resource use. BAP-65 may represent a useful adjunct in the initial assessment of AECOPDs.

Shorr AF; Sun X; Johannes RS; Yaitanes A; Tabak YP

2011-11-01

314

Commentary: missing heritability, polygenic scores, and gene-environment correlation.  

UK PubMed Central (United Kingdom)

This special issue amply fulfils its aim of moving the study of gene × environment (GE) interplay forward constructively and creatively, exploiting contributions from diverse disciplines. Rather than discussing the many interesting findings and methods in this special issue, I will comment on two cross-cutting issues - one about genes and the other about the environment - that came to mind as I read these articles.

Plomin R

2013-10-01

315

Generic pain intensity scores are affected by painful comorbidity.  

UK PubMed Central (United Kingdom)

AIMS: To determine the degree to which the generic pain intensity rating (i.e., overall and without reference to a particular body site) of facial pain patients being seen in a specialty setting for facial pain is influenced by painful comorbidity in body parts other than the face. METHODS: In this prospective study, 40 consecutive female temporomandibular pain patients rated their generic pain on a 100-mm visual analog scale. After marking all painful body sites on pain drawings, patients were asked to rate the pain intensity for each of the indicated pain sites; the patients did not have access to the generic pain intensity score. Pearson's correlation coefficient was used to correlate the generic pain intensity score with site-specific pain intensity ratings, their mean and maximum, and the number of pain sites. RESULTS: The medians of the generic, maximum, and facial pain intensity scores were 49.5, 53, and 45.5, respectively. The generic pain intensity rating correlated more highly with the intensity scores reported for the most painful body site (r2 = 0.82; P < 0.001) than with the average rating across all painful sites (r2 = 0.62; P < 0.001), or the pain intensity score in the face (r2 = 0.61; P < 0.001). The number of pain sites did not correlate to any statistically significant degree with the generic pain intensity rating (r2 = 0.006; P = 0.65). CONCLUSION: The results of this study suggest that the maximum visual analog scale pain intensity score, observed in any body location, is a better reflection of the generic pain intensity rating than the corresponding score of the face. To avoid over-rating or underrating of facial pain intensity, patients should be instructed to provide site-specific pain intensity scores if painful comorbidity is present.

Türp JC; Kowalski CJ; Stohler CS

2000-01-01

316

Clinical correlates of atypical depression and validation of the French version of the Scale for Atypical Symptoms (SAS).  

UK PubMed Central (United Kingdom)

BACKGROUND: The 8-item "Scale for Atypical Symptoms" (SAS) and its structured interview, the SIGH-SAD, have been developed to assess atypical symptoms of depression in winter depression. Although they are commonly used, no validation study has yet been conducted. METHODS: 270 consecutive depressed inpatients were assessed prospectively. Pearson's correlation coefficients between fulfilment of Liebowitz criteria for atypical depression and both the SAS score and the atypical balance [ratio of the AS score to the total score on the Hamilton Depression Rating Scale 29-item (HDRS-29)] were calculated. The SAS was evaluated against Liebowitz criteria using binary logistic regression. A ROC curve was performed with the atypical balance against the fulfilment of Liebowitz criteria. RESULTS: 18.5% of patients met the criteria for atypical depression. The presence of an atypical depression was significantly correlated with both the atypical score (r=0.42) and the atypical balance (r=0.51). The logistic regression showed that a higher score on the SAS, the absence of a somatic syndrome (ICD-10) and a lower HDRS-21 score were independent predictors of an atypical depression while age, gender and bipolarity were not. The ROC curve showed that an atypical balance of 29% was the optimal threshold for the diagnosis of atypical depression (sensitivity=0.86, specificity=0.79). LIMITATION: Patients with bipolar I and II were not distinguished. CONCLUSION: Atypical depression is relatively frequent in hospitalised patients. The concurrent validity of the French version of the SAS and its structured interview, the SIGH-SAD is satisfactory.

Thuile J; Even C; Musa C; Friedman S; Rouillon F

2009-11-01

317

Monoclonal antibody humanness score and its applications.  

UK PubMed Central (United Kingdom)

BACKGROUND: Monoclonal antibody therapeutics are rapidly gaining in popularity for the treatment of a myriad of diseases, ranging from cancer to autoimmune diseases and neurological diseases. Multiple forms of antibody therapeutics are in use today that differ in the amount of human sequence present in both the constant and variable regions, where antibodies that are more human-like usually have reduced immunogenicity in clinical trials. RESULTS: Here we present a method to quantify the humanness of the variable region of monoclonal antibodies and show that this method is able to clearly distinguish human and non-human antibodies with excellent specificity. After creating and analyzing a database of human antibody sequences, we conducted an in-depth analysis of the humanness of therapeutic antibodies, and found that increased humanness score is correlated with decreased immunogenicity of antibodies. We further discovered a surprisingly similarity in the immunogenicity of fully human antibodies and humanized antibodies that are more human-like based on their humanness score. CONCLUSIONS: Our results reveal that in most cases humanizing an antibody and confirming the humanness of the final form may be sufficient to eliminate immunogenicity issues to the same extent as using fully human antibodies. We created a public website to calculate the humanness score of any input antibody sequence based on our human antibody database. This tool will be of great value during the preclinical drug development process for new monoclonal antibody therapeutics.

Gao SH; Huang K; Tu H; Adler AS

2013-01-01

318

On prioritized multiple-criteria aggregation.  

UK PubMed Central (United Kingdom)

We describe multicriteria aggregation and discuss its central role in many modern applications. The concept of aggregation imperative is introduced to indicate the description of how the individual criteria satisfactions should be combined to obtain the overall score. We focus on a particular type of aggregation imperative called prioritized aggregation that is characteristic of situations where lack of satisfaction to criteria denoted as higher priority cannot be compensated by increased satisfaction by those denoted as lower priority. We discuss two approaches to the formulation of this type of aggregation process. One of these uses the prioritized aggregation operator, and the second is based on an integral-type aggregation using a monotonic set measure to convey the prioritized imperative.

Yager RR

2012-10-01

319

Can score databanks help teaching?  

UK PubMed Central (United Kingdom)

BACKGROUND: Basic courses in most medical schools assess students' performance by conferring scores. The objective of this work is to use a large score databank for the early identification of students with low performance and to identify course trends based on the mean of students' grades. METHODOLOGY/PRINCIPAL FINDINGS: We studied scores from 2,398 medical students registered in courses over a period of 10 years. Students in the first semester were grouped into those whose ratings remained in the lower quartile in two or more courses (low-performance) and students who had up to one course in the lower quartile (high-performance). ROC curves were built, aimed at the identification of a cut-off average score in the first semesters that would be able to predict low performances in future semesters. Moreover, to follow the long-term pattern of each course, the mean of all scores conferred in a semester was compared to the overall course mean obtained by averaging 10 years of data. Individuals in the low-performance group had a higher risk of being in the lower quartile of at least one course in the second semester (relative risk 3.907; 95% CI: 3.378-4.519) and in the eighth semester (relative risk 2.873; 95% CI: 2.495-3.308). The prediction analysis revealed that an average score of 7.188 in the first semester could identify students that presented scores below the lower quartiles in both the second and eighth semesters (p<0.0001 for both AUC). When scores conferred by single courses were compared over time, three time-trend patterns emerged: low variation, upward trend and erratic pattern. CONCLUSION/SIGNIFICANCE: An early identification of students with low performance may be useful in promoting pedagogical strategies for these individuals. Evaluation of the time trend of scores conferred by courses may help departments monitoring changes in personnel and methodology that may affect a student's performance.

de Mendonça VR; Andrade BB; Almeida A; Barral-Netto M

2011-01-01

320

Cerebral hemispherectomy: sensory scores before and after intensive mobility training.  

UK PubMed Central (United Kingdom)

PURPOSE: It is unclear whether sensory modalities can be modified by rehabilitation and if sensory functions vary on the affected side many years after cerebral hemispherectomy. This pilot, proof-of-concept study assessed light touch and proprioception before and after 10 days of intensive mobility training in individuals after hemispherectomy. METHODS: Light touch and proprioception of the upper and lower extremity was measured using the Fugl-Meyer sensory subtest on the paretic side in 18 individuals with hemispherectomy before and after mobility training. Sensory scores and differences related to mobility training were compared with clinical variables. RESULTS: Patients were 7.1±5.7 years from time of surgery to sensory assessment and mobility training. Light touch scores were 81±22% and proprioception values were 64±23% of normal (p=0.0022). Light touch did not correlate with proprioception scores, and differences comparing after with before mobility training did not correlate. In multivariate analysis, younger age at seizure onset correlated with better light touch scores, and older age at onset correlated with improvements in light touch scores with mobility training. By comparison, proprioception scores were better in individuals with perinatal infarcts compared with Rasmussen encephalitis and Sturge-Weber. Post-training, proprioception scores were better in Sturge-Weber cases. CONCLUSION: Light touch was less affected than proprioception on the paretic side after cerebral hemispherectomy. Improvements with mobility training correlated with older age at seizure onset and etiology. These findings suggest that many years after epilepsy surgery sensory functions are not static supporting the notion of existing developmental neuroplasticity of the remaining cerebral cortex along with brain stem and spinal cord pathways.

de Bode S; Fritz S; Mathern GW

2012-09-01

 
 
 
 
321

Diagnostic criteria of dementia.  

Science.gov (United States)

In the past two decades there has been a tremendous effort among clinicians and searchers to improve the diagnostic criteria of the dementias on the basis of the differential neurological and neuropsychological profiles. This was an obligatory requirement for clinical trials and the development of treatments. Over the years it became rapidly evident that the cohorts of patients in studies had some degree of heterogeneity, making it difficult to interpret the results of some studies, particularly in the vascular dementias and the mild cognitive impairment (MCI) group. For example, many sub-types of the vascular group were included in clinical trials, such as the cortical strokes, the lacunar states and the diffuse white matter disease cases, and some of the patients might have had also mixed pathology. In addition, the standard DSM IV criteria for dementia no longer represent our present knowledge of the clinical profile of some of the dementias such as vascular dementia (VaD) and fronto-temporal dementia where the memory impairment is not necessarily the first requirement. To improve the validity of clinical trials and eventually help developing more appropriate treatments, we revised the present diagnostic criteria and made recommendations for some changes in the context of the 2nd Canadian Conference on the Development of Antidementia Therapies, held in 2004 and reviewed in the light of the recent literature as of early 2006. It is expected that in the near future, these dementia criteria for clinical trials will have to be revised again in order to include specific subtypes of the dementias as well as biomarkers, structural and functional imaging. PMID:17469675

Bouchard, Rémi W

2007-03-01

322

Interpreting linked psychomotor performance scores.  

UK PubMed Central (United Kingdom)

Given that equating/linking applications are now appearing in kinesiology literature, this article provides an overview of the different types of linked test scores: equated, concordant, and predicted. It also addresses the different types of evidence required to determine whether the scores from two different field tests (measuring the same construct) can be used interchangeably (equated). Thus, evidence issues are addressed to help the reader determine whether the creation of equipercentile equated or concordant scores is appropriate and useful. The article is organized according to the following issues: (a) the degree to which the two tests measure the same construct, (b) the equating/linking process, (c) the evaluation of equating/ linking function, and (d) stability of equating/linking function across populations.

Looney MA

2013-03-01

323

Influence of low-stress handling on reactivity score and pregnancy rate during fixed-time artificial insemination in Nellore cows  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english The objective of this work was to evaluate the influence of low-stress handling (LSH) on reactivity score and pregnancy rate during fixed-time artificial insemination (FTAI) for extensively raised Nellore cows. Multiparous cows (n = 126) were randomly allocated into two groups: G1 (n = 66) and G2, the control group (n = 60). Group G1 was subjected to LSH, in which the animals were handled in a calm and quiet manner, without loud noises or physical aggression, using the po (more) int of balance, respecting the flight zone and using flags to supplement handling. Group G2 was handled following the typical procedure, with yelling, kicking and the use of electric prods and sticks. On D0, D8 and D10, FTAI was performed in both groups. Reactivity was scored on D0, D8 and D10 at the squeeze chute, based on the tension score, breathing score, and bellowing score. Using the three criteria above, the reactivity scores were defined as follows: R1 (calm); R2 (slightly reactive); R3 (moderately reactive); R4 (reactive); and R5 (highly reactive). Thirty-five days after artificial insemination, pregnancy was determined using ultrasonography. There was no significant correlation between reactivity score and pregnancy rate in each group or between the pregnancy rates in both groups. However, there was a statistically significant difference between the G1 and G2 groups with regard to reactivity score (1.62±0.05 vs. 2.12±0.07). Low-stress handling influenced reactivity but did not affect pregnancy rate in extensively raised Nellore cows subjected to FTAI.

Tirloni, Rayf Roberto; Rocha, Fábio Alcântara; Lourenço, Fábio José; Martins, Lílian Rigatto

2013-07-01

324

Development and validation of a composite scoring system for robot-assisted surgical training-the Robotic Skills Assessment Score.  

UK PubMed Central (United Kingdom)

BACKGROUND: A standardized scoring system does not exist in virtual reality-based assessment metrics to describe safe and crucial surgical skills in robot-assisted surgery. This study aims to develop an assessment score along with its construct validation. MATERIALS AND METHODS: All subjects performed key tasks on previously validated Fundamental Skills of Robotic Surgery curriculum, which were recorded, and metrics were stored. After an expert consensus for the purpose of content validation (Delphi), critical safety determining procedural steps were identified from the Fundamental Skills of Robotic Surgery curriculum and a hierarchical task decomposition of multiple parameters using a variety of metrics was used to develop Robotic Skills Assessment Score (RSA-Score). Robotic Skills Assessment mainly focuses on safety in operative field, critical error, economy, bimanual dexterity, and time. Following, the RSA-Score was further evaluated for construct validation and feasibility. Spearman correlation tests performed between tasks using the RSA-Scores indicate no cross correlation. Wilcoxon rank sum tests were performed between the two groups. RESULTS: The proposed RSA-Score was evaluated on non-robotic surgeons (n = 15) and on expert-robotic surgeons (n = 12). The expert group demonstrated significantly better performance on all four tasks in comparison to the novice group. Validation of the RSA-Score in this study was carried out on the Robotic Surgical Simulator. CONCLUSION: The RSA-Score is a valid scoring system that could be incorporated in any virtual reality-based surgical simulator to achieve standardized assessment of fundamental surgical tents during robot-assisted surgery.

Chowriappa AJ; Shi Y; Raza SJ; Ahmed K; Stegemann A; Wilding G; Kaouk J; Peabody JO; Menon M; Hassett JM; Kesavadas T; Guru KA

2013-07-01

325

Docking and scoring of metallo-beta-lactamases inhibitors  

DEFF Research Database (Denmark)

The performance of the AutoDock, GOLD and FlexX docking programs was evaluated for docking of dicarboxylic acid inhibitors into metallo-beta-lactamases (MBLs). GOLD provided the best overall performance, with RMSDs between experimental and docked structures of 1.8-2.6 A and a good correlation between the experimentally determined MBL-inhibitor affinities and the GOLD scores. GOLD was selected for a test including a broad spectrum of inhibitors for which experimental MBL-inhibitor binding affinities are available. This study revealed that (1) for most compound classes (dicarboxylic acids, tetrazoles, sulfonylhydrazones, and peptide-like compounds) there is a good correlation between the experimentally determined MBL-inhibitor affinities and the GOLD scores, (2) the correlation only holds within a given class, that is, scores of compounds from different classes cannot be directly compared, (3) for some compound classes (e.g. small sulphur compounds) there is no direct correlation between the experimentally determined MBL-inhibitor affinities and the GOLD scores. Using partial least squares methods, a model with R2 = 0.82 and Q2 = 0.78 for the training set was obtained based on the GOLD score and descriptors associated with binding of the IMP-1 inhibitors to the enzyme. The external Q2 for the test set is 0.73. This final model for prediction of IMP-1 MBL-inhibitor affinity handled all known classes of MBL-inhibitors, except small sulphur compounds.

Olsen, Lars; Pettersson, Ingrid

2004-01-01

326

Doença de Kimura não é hiperplasia angiolinfóide com eosinofilia: correlação clinicopatológica com revisão da literatura e definição de critérios diagnósticos/ Kimura disease is not angiolymphoid hyperplasia with eosinophilia: clinical and pathological correlation with literature review and definition of diagnostic criteria  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A doença de Kimura é doença inflamatória crônica que se manifesta como crescimento tumoral indolor na região da cabeça e do pescoço, freqüentemente associada à linfoadenopatia cervical. Por ser doença rara, ter sido descrita inicialmente na literatura oriental e ter características em comum com a hiperplasia angiolinfóide com eosinofilia, a doença de Kimura tem sido confundida com essa enfermidade, da qual deve ser distinguida. Neste artigo, revisam-se as ca (more) racterísticas clínicas e histopatológicas e apresentam-se critérios para a diferenciação dessas duas entidades. Abstract in english Kimura disease is a rare chronic inflammatory disease that presents as a tumor-like swelling in the head and neck region and is often associated with regional cervical lymphadenopathy. Cases have been described predominantly in the oriental literature. Kimura disease has been confused with angiolymphoid hyperplasia with eosinophilia, for having common characteristics, but both conditions should be differentiated. In this article, the clinical and histopathological characteristics are revised and the criteria to differentiate the two conditions are presented.

Briggs, Pedro Leonardo