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Sample records for score criteria correlating

  1. HER2 amplification in gastroesophageal adenocarcinoma: correlation of two antibodies using gastric cancer scoring criteria, H score, and digital image analysis with fluorescence in situ hybridization.

    Science.gov (United States)

    Radu, Oana M; Foxwell, Tyler; Cieply, Kathleen; Navina, Sarah; Dacic, Sanja; Nason, Katie S; Davison, Jon M

    2012-04-01

    We assessed 103 resected gastroesophageal adenocarcinomas for HER2 amplification by fluorescence in situ hybridization (FISH) and 2 commercial immunohistochemical assays. Of 103, 30 (29%) were FISH-amplified. Both immunohistochemical assays had greater than 95% concordance with FISH. However, as a screening test for FISH amplification, the Ventana Medical Systems (Tucson, AZ) 4B5 antibody demonstrated superior sensitivity (87%) compared with the DAKO (Carpinteria, CA) A0485 (70%). Of the cases, 28 were immunohistochemically 3+ or immunohistochemically 2+/FISH-amplified with the 4B5 assay compared with only 22 cases with the A0485 assay, representing a large potential difference in patient eligibility for anti-HER2 therapy. Cases with low-level FISH amplification (HER2/CEP17, 2.2-4.0) express lower levels of HER2 protein compared with cases with high-level amplification (HER2/CEP17, ?4.0), raising the possibility of a differential response to anti-HER2 therapy. The H score and digital image analysis may have a limited role in improving HER2 test performance. PMID:22431535

  2. 50 CFR 91.23 - Scoring criteria for contest.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Scoring criteria for contest. 91.23... (CONTINUED) MISCELLANEOUS PROVISIONS MIGRATORY BIRD HUNTING AND CONSERVATION STAMP CONTEST Procedures for Administering the Contest § 91.23 Scoring criteria for contest. Entries will be judged on the basis...

  3. Score Calculation in Informatics Contests Using Multiple Criteria Decision Methods

    Directory of Open Access Journals (Sweden)

    Jurate SKUPIENE

    2011-04-01

    Full Text Available The Lithuanian Informatics Olympiad is a problem solving contest for high school students. The work of each contestant is evaluated in terms of several criteria, where each criterion is measured according to its own scale (but the same scale for each contestant. Several jury members are involved in the evaluation. This paper analyses the problem how to calculate the aggregated score for whole submission in the above mentioned situation. The chosen methodology for solving this problem is Multiple Criteria Decision Analysis (MCDA. The outcome of this paper is the score aggregation method proposed to be applied in LitIO developed using MCDA approaches.

  4. Housing Score : Its Correlation With Morbidity Profile

    Directory of Open Access Journals (Sweden)

    Bansal R.K

    1992-01-01

    Full Text Available Various studies have focused attention on the relationship between housing and health and have established residential environment as an important determinant of the health status of its residents. However, there is a paucity of research work on the development and assessment of comprehensive and quantifiable housing scores and their correlation with the general morbidity profile of residents. Such mathematical housing assessment scores may provide a valuable foresight to city and health planners. In the present study, 2,536 individuals from 542 families, residing in 5 different types of houses were analysed. The residential environment was quantified by using a scoring system developed by Desai and the families were grouped into 3 categories accordingly. A complete health check up of all residents was undertaken to ascertain their disease profile. It was observed that high housing scores were significantly associated with an increase in non- communicable diseases and diseases of the nervous and respiratory systems, while low scores had a high prevalence of communicable, infectious and parasitic diseases. The findings were validated by a repeat assessment using individual parameters separately.

  5. Criteria for measures of quantum correlations

    CERN Document Server

    Brodutch, Aharon

    2011-01-01

    Entanglement does not describe all quantum correlations and several authors have shown the need to go beyond entanglement when dealing with mixed states. Several different measures have sprung up in the literature, for a variety of reasons, To describe quantum correlations; some are known under the collective name quantum discord. Yet, in the same sprit as the criteria for entanglement measures, there is no general mechanism that determines whether a measure of quantum and classical correlations is a proper measure of correlations. This is partially due to the fact that the answer is a bit muddy. In this article we attempt tackle this muddy topic by writing down several criteria for a "good" measure of correlations. We breakup our list into necessary, reasonable, and debatable conditions. We then proceed to prove several of these conditions for generalized measures of quantum correlations. However, not all conditions are met by all measures; we show this via several examples. The reasonable conditions are rel...

  6. Correlation between NIH composite skin score, patient-reported skin score, and outcome: results from the Chronic GVHD Consortium

    OpenAIRE

    Jacobsohn, David A.; Kurland, Brenda F.; Pidala, Joseph; Inamoto, Yoshihiro; Chai, Xiaoyu; Palmer, Jeanne M.; Arai, Sally; Arora, Mukta; Jagasia, Madan; Cutler, Corey; Weisdorf, Daniel; Martin, Paul J.; Pavletic, Steven Z; Vogelsang, Georgia; Lee, Stephanie J

    2012-01-01

    There are no validated criteria to measure skin response in chronic GVHD. In a prospectively assembled, multicenter cohort of patients with chronic GVHD (N = 458), we looked for correlation of change in several different scales recommended by the National Institutes of Health (NIH) Consensus with clinician and patient perception of change and overall survival. Of the clinician scales, the NIH composite 0-3 skin score was the only one that correlated with both clinician and patient perception ...

  7. Personality and Examination Score Correlates of Abnormal Psychology Course Ratings.

    Science.gov (United States)

    Pauker, Jerome D.

    The relationship between the ratings students assigned to an evening undergraduate abnormal psychology class and their scores on objective personality tests and course examinations was investigated. Students (N=70) completed the MMPI and made global ratings of the course; these scores were correlated separately by sex with the T scores of 13 MMPI…

  8. HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma

    OpenAIRE

    Hu, Yingchuan; Bandla, Santhoshi; Godfrey, Tony E.; Tan, DongFeng; Luketich, James D; Pennathur, Arjun; Qiu, Xing; Hicks, David G.; Peters, Jeffrey; Zhou, Zhongren

    2011-01-01

    The HER2 oncogene was recently reported to be amplified and overexpressed in esophageal adenocarcinoma. However, the relationship of HER2 amplification in esophageal adenocarcinoma with prognosis has not been well defined. The scoring systems for clinically evaluating HER2 in esophageal adenocarcinoma are not established. The aims of the study were to establish a HER2 scoring system and comprehensively investigate HER2 amplification and overexpression in esophageal adenocarcinoma and its prec...

  9. The Correlation Between GRE Scores and Performance in Graduate School

    Science.gov (United States)

    Morin, David

    1996-05-01

    We investigate the correlation between GRE scores and various measures of performance for graduate students in the Physics Department at Harvard University. We consider students who entered the program between 1980 and 1989. The degree to which GRE scores can predict performance is shown for different subgroups of students.

  10. Score Calculation in Informatics Contests Using Multiple Criteria Decision Methods

    Science.gov (United States)

    Skupiene, Jurate

    2011-01-01

    The Lithuanian Informatics Olympiad is a problem solving contest for high school students. The work of each contestant is evaluated in terms of several criteria, where each criterion is measured according to its own scale (but the same scale for each contestant). Several jury members are involved in the evaluation. This paper analyses the problem…

  11. Factors Correlated with Neuroticism Scores for Married Women.

    Science.gov (United States)

    Moffitt, Paul F.; Eisen, Peter

    1982-01-01

    Found a significant positive correlation between wives' (but not husbands') neuroticism scores and the degree to which the couple is apart on Lanyon's extraversion-introversion scale. Further correlations suggest fewer intimate communications and agreements between highly diverging couples. Theorized that this constellation of factors leads to…

  12. Correlation of admission criteria with dental school performance and attrition.

    Science.gov (United States)

    Sandow, Pamela L; Jones, Anne C; Peek, Chuck W; Courts, Frank J; Watson, Ronald E

    2002-03-01

    This study was conducted to provide current information on the relationship between admission criteria and dental school performance, including the association of admission criteria and dental school outcomes such as remediation and attrition. Standard tests of bivariate association and multivariate regression models appropriate for continuous and discrete dependent variables were used to examine the relationship between multiple indicators of admission criteria and dental school performance for six recent classes at the University of Florida College of Dentistry (UFCD). The admission criteria included the undergraduate science grade point average (GPA), undergraduate non-science GPA, Dental Admissions Test (DAT) academic score, Perceptual Motor Aptitude Test (PMAT) score, and admission interview score. Measures of dental school performance were the National Dental Board Examination Part I and Part II (NB-I, NB-II) scores, yearly and final dental school GPA, and academic progress through the UFCD program. In general, most admission criteria were good bivariate indicators of dental school performance. Multivariate analyses indicated that students with higher undergraduate science GPAs and DAT academic scores were more likely to achieve higher NB-I and NB-II scores. The undergraduate science GPA and admission interview score were the most consistent determinants of dental school GPA. Students with lower undergraduate science GPAs, DAT academic scores, and PMAT scores were more likely to remediate, to repeat an academic year, or to be dismissed. Although bivariate differences were observed in several admission criteria of students who remediated one or more courses, repeated an academic year, or were dismissed only the undergraduate science GPA and the PMAT score were indicators of programmatic progress in the multivariate analysis. PMID:11936229

  13. HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma.

    Science.gov (United States)

    Hu, Yingchuan; Bandla, Santhoshi; Godfrey, Tony E; Tan, Dongfeng; Luketich, James D; Pennathur, Arjun; Qiu, Xing; Hicks, David G; Peters, Jeffrey H; Zhou, Zhongren

    2011-07-01

    The HER2 oncogene was recently reported to be amplified and overexpressed in esophageal adenocarcinoma. However, the relationship of HER2 amplification in esophageal adenocarcinoma with prognosis has not been well defined. The scoring systems for clinically evaluating HER2 in esophageal adenocarcinoma are not established. The aims of the study were to establish a HER2 scoring system and comprehensively investigate HER2 amplification and overexpression in esophageal adenocarcinoma and its precursor lesion. Using a tissue microarray, containing 116 cases of esophageal adenocarcinoma, 34 cases of Barrett's esophagus, 18 cases of low-grade dysplasia and 15 cases of high-grade dysplasia, HER2 amplification and overexpression were analyzed by HercepTest and chromogenic in situ hybridization methods. The amplification frequency in an independent series of 116 esophageal adenocarcinoma samples was also analyzed using Affymetrix SNP 6.0 microarrays. In our studies, we have found that HER2 amplification does not associate with poor prognosis in total 232 esophageal adenocarcinoma patients by chromogenic in situ hybridization and high-density microarrays. We further confirm the similar frequency of HER2 amplification by chromogenic in situ hybridization (18%; 21 out of 116) and SNP 6.0 microarrays (16%, 19 out of 116) in esophageal adenocarcinoma. HER2 protein overexpression was observed in 12% (14 out of 116) of esophageal adenocarcinoma and 7% (1 out of 15) of high-grade dysplasia. No HER2 amplification or overexpression was identified in Barrett's esophagus or low-grade dysplasia. All HER2 protein overexpression cases showed HER2 gene amplification. Gene amplification was found to be more frequent by chromogenic in situ hybridization than protein overexpression in esophageal adenocarcinoma (18 vs 12%). A modified two-step model for esophageal adenocarcinoma HER2 testing is recommended for clinical esophageal adenocarcinoma HER2 trial. PMID:21460800

  14. The relationship between the ability to identify evaluation criteria and integrity test scores

    Directory of Open Access Journals (Sweden)

    CORNELIUS J. KÖNIG

    2006-09-01

    Full Text Available It has been argued that applicants who have the ability to identify what kind of behavior is evaluated positively in a personnel selection situation can use this information to adapt their behavior accordingly. Although this idea has been tested for assessment centers and structured interviews, it has not been studied with regard to integrity tests (or other personality tests. Therefore, this study tested whether candidates’ ability to identify evaluation criteria (ATIC correlates with their integrity test scores. Candidates were tested in an application training setting (N = 92. The results supported the idea that ATIC also plays an important role for integrity tests. New directions for future research are suggested based on this finding.

  15. Vitiligo Extent Tensity Index (VETI) score: a new definition, assessment and treatment evaluation criteria in vitiligo

    OpenAIRE

    Feily, Amir

    2014-01-01

    Although skin is the largest organ of the body, there are no standardized reproducible methods for assessing severity of many skin diseases. Due to lack of consensus, methods of assessment and inexistence of precise scoring system, there is no application for vitiligo estimation in real practice. In this paper the author describes VETI score as a new treatment evaluation criteria and severity assessment method for vitiligo. This new tool, as does the PASI score in psoriasis, may be able to pr...

  16. Diffusion abnormality maps in demyelinating disease: Correlations with clinical scores

    International Nuclear Information System (INIS)

    Background and purpose: Magnetic resonance imaging (MRI) has been explored as a noninvasive tool to assess pathology in multiple sclerosis (MS) patients. However, the correlation between classical MRI measures and physical disability is modest in MS. The diffusion tensor imaging (DTI) MRI technique holds particular promise in this regard. The present study shows brain regions where FA and individual diffusivities abnormalities are present and check their correlations with physical disability clinical scores. Methods: Eight patients and 12 matched healthy controls were recruited. The Multiple Sclerosis Functional Composite was administered. For MR-DTI acquisitions, a Genesis Signa 1.5T MR system, an EP/SE scanning sequence, 25 gradient directions were used. Results: Tract Based Spatial Statistics (TBSS) group comparisons showed reduced FA and increased individual diffusivities in several brain regions in patients. Significant correlations were found between FA and: EDSS, 9-HPT(NON)DOM and 25FW score; between ?2 and: P100 (r and l), 9-HPT(NON)DOM and 25FW; between ?3 and: 9-HPT(NON)DOM and 25FW score. Conclusions: Fractional anisotropy and individual radial diffusivities proved to be important markers of motor disabilities in MS patients when the disease duration mean and the disability scores values range are relatively high.

  17. Automatic sleep scoring in normals and in individuals with neurodegenerative disorders according to new international sleep scoring criteria

    DEFF Research Database (Denmark)

    Jensen, Peter S; Sorensen, Helge B D; Jennum, Poul; Leonthin, Helle

    2010-01-01

    The aim of this study was to develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine. A biomedical signal processing algorithm was developed, allowing for automatic sleep depth...... quantification of routine polysomnographic recordings through feature extraction, supervised probabilistic Bayesian classification, and heuristic rule-based smoothing. The performance of the algorithm was tested using 28 manually classified day-night polysomnograms from 18 normal subjects and 10 patients with...... Parkinson disease or multiple system atrophy. This led to quantification of automatic versus manual epoch-by-epoch agreement rates for both normals and abnormals. Resulting average agreement rates were 87.7% (Cohen's Kappa: 0.79) and 68.2% (Cohen's Kappa: 0.26) in the normal and abnormal group, respectively...

  18. Automatic Sleep Scoring in Normals and in Individuals with Neurodegenerative Disorders According to New International Sleep Scoring Criteria

    DEFF Research Database (Denmark)

    Jensen, Peter S.; Sørensen, Helge Bjarup Dissing; Leonthin, Helle; Jennum, Poul

    2010-01-01

    The aim of this study was to develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine. A biomedical signal processing algorithm was developed, allowing for automatic sleep depth...... quantification of routine polysomnographic recordings through feature extraction, supervised probabilistic Bayesian classification, and heuristic rule-based smoothing. The performance of the algorithm was tested using 28 manually classified day-night polysomnograms from 18 normal subjects and 10 patients with...... Parkinson disease or multiple system atrophy. This led to quantification of automatic versus manual epoch-by-epoch agreement rates for both normals and abnormals. Resulting average agreement rates were 87.7% (Cohen's Kappa: 0.79) and 68.2% (Cohen's Kappa: 0.26) in the normal and abnormal group, respectively...

  19. Automatic sleep scoring in normals and in individuals with neurodegenerative disorders according to new international sleep scoring criteria

    DEFF Research Database (Denmark)

    Jensen, Peter S.; Sørensen, Helge Bjarup Dissing; Jennum, P. J.

    Medicine (AASM). Methods: A biomedical signal processing algorithm was developed, allowing for automatic sleep depth quantification of routine polysomnographic (PSG) recordings through feature extraction, supervised probabilistic Bayesian classification, and heuristic rule-based smoothing. The performance......Introduction: Reliable polysomnographic classification is the basis for evaluation of sleep disorders in neurological diseases. Aim: To develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep...... of the algorithm was tested using 28 manually classified day-night PSGs from 18 normal subjects and 10 patients with Parkinson's disease (PD) or multiple system atrophy (MSA). This led to quantification of automaticversus- manual epoch-by-epoch agreement rates for both normal and abnormal recordings...

  20. Automatic Sleep Scoring in Normals and in Individuals with Neurodegenerative Disorders According to New International Sleep Scoring Criteria

    DEFF Research Database (Denmark)

    Jensen, Peter S.; SØrensen, Helge Bjarup Dissing

    2010-01-01

    The aim of this study was to develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine. A biomedical signal processing algorithm was developed, allowing for automatic sleep depth quantification of routine polysomnographic recordings through feature extraction, supervised probabilistic Bayesian classification, and heuristic rule-based smoothing. The performance of the algorithm was tested using 28 manually classified day-night polysomnograms from 18 normal subjects and 10 patients with Parkinson disease or multiple system atrophy. This led to quantification of automatic versus manual epoch-by-epoch agreement rates for both normals and abnormals. Resulting average agreement rates were 87.7% (Cohen's Kappa: 0.79) and 68.2% (Cohen's Kappa: 0.26) in the normal and abnormal group, respectively. Based on an observed reliability of the manual scorer of 92.5% (Cohen's Kappa: 0.87) in the normal group and 85.3% (Cohen's Kappa: 0.73) in the abnormal group, this study concluded that although the developed algorithm was capable of scoring normal sleep with an accuracy around the manual interscorer reliability, it failed in accurately scoring abnormal sleep as encountered for the Parkinson disease/multiple system atrophy patients.

  1. Automatic sleep scoring in normals and in individuals with neurodegenerative disorders according to new international sleep scoring criteria

    DEFF Research Database (Denmark)

    Jensen, Peter S.; SØrensen, Helge Bjarup Dissing

    2010-01-01

    Introduction: Reliable polysomnographic classification is the basis for evaluation of sleep disorders in neurological diseases. Aim: To develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine (AASM). Methods: A biomedical signal processing algorithm was developed, allowing for automatic sleep depth quantification of routine polysomnographic (PSG) recordings through feature extraction, supervised probabilistic Bayesian classification, and heuristic rule-based smoothing. The performance of the algorithm was tested using 28 manually classified day-night PSGs from 18 normal subjects and 10 patients with Parkinson's disease (PD) or multiple system atrophy (MSA). This led to quantification of automaticversus- manual epoch-by-epoch agreement rates for both normal and abnormal recordings. Results: Resulting average agreement rates were 87.7% (Cohen’s Kappa: 0.79) and 68.2%(Cohen’s Kappa: 0.26) in the normal and abnormal group, respectively. Based on an observed reliability of the manual scorer of 92.5% (Cohen’s Kappa: 0.87) in the normal group and 85.3% (Cohen’s Kappa: 0.73) in the abnormal group. Conclusion: The developed algorithm was capable of scoring normal sleep with an accuracy around the manual inter-scorer reliability, it failed in accurately scoring abnormal sleep as encountered for the PD/MSA patients, which is due to the abnormal micro- and macrostructure pattern in these patients.

  2. Spectrophotometric skin measurements correlate with EORTC/RTOG-common toxicity criteria

    International Nuclear Information System (INIS)

    Purpose: it was investigated whether the elementary EORTC/RTOG-CTC score (Common Toxicity Criteria) for radiotherapy skin reactions correlates with spectrophotometric measurements of the skin color. Patients, material, and methods: in 41 patients irradiated for unilateral breast cancer the regular scoring by CTC was done during radiotherapy. In parallel, a total of 4,920 spectrophotometric measurements to determine the skin color were performed at baseline, at the beginning of radiotherapy, and at 20, 40 and 60 Gy. The nonirradiated contralateral breast was used for control measurements. Results: as expected, the skin color (especially red) depended on the radiation dose applied to the skin. The objective spectrophotometric measurements were found to correlate well with the subjective CTC scores. Conclusion: for classification of acute radiation toxicity there seems to be no need to replace the common CTC scoring by technical methods. (orig.)

  3. Spectrophotometric skin measurements correlate with EORTC/RTOG-common toxicity criteria

    Energy Technology Data Exchange (ETDEWEB)

    Momm, F.; Bartelt, S.; Haigis, K.; Grosse-Sender, A. [Dept. of Radiotherapy, Univ. Hospital Freiburg, Freiburg i.Br. (Germany); Witucki, G. [Radiotherapeutic Dept., Diakonie-Krankenhaus Schwaebisch-Hall, Schwaebisch-Hall (Germany)

    2005-06-01

    Purpose: it was investigated whether the elementary EORTC/RTOG-CTC score (Common Toxicity Criteria) for radiotherapy skin reactions correlates with spectrophotometric measurements of the skin color. Patients, material, and methods: in 41 patients irradiated for unilateral breast cancer the regular scoring by CTC was done during radiotherapy. In parallel, a total of 4,920 spectrophotometric measurements to determine the skin color were performed at baseline, at the beginning of radiotherapy, and at 20, 40 and 60 Gy. The nonirradiated contralateral breast was used for control measurements. Results: as expected, the skin color (especially red) depended on the radiation dose applied to the skin. The objective spectrophotometric measurements were found to correlate well with the subjective CTC scores. Conclusion: for classification of acute radiation toxicity there seems to be no need to replace the common CTC scoring by technical methods. (orig.)

  4. A Chronic Fatigue Syndrome (CFS) severity score based on case designation criteria

    OpenAIRE

    James N. BARANIUK; Adewuyi, Oluwatoyin; Merck, Samantha Jean; Ali, Mushtaq; Ravindran, Murugan K.; Timbol, Christian R; Rayhan, Rakib; Zheng, Yin; Le, Uyenphuong; Esteitie, Rania; Petrie, Kristina N

    2013-01-01

    Background: Chronic Fatigue Syndrome case designation criteria are scored as physicians’ subjective, nominal interpretations of patient fatigue, pain (headaches, myalgia, arthralgia, sore throat and lymph nodes), cognitive dysfunction, sleep and exertional exhaustion. Methods: Subjects self-reported symptoms using an anchored ordinal scale of 0 (no symptom), 1 (trivial complaints), 2 (mild), 3 (moderate), and 4 (severe). Fatigue of 3 or 4 distinguished “Fatigued” from “Not Fatigued” subjects....

  5. Correlations between Knee Society Function Scores and Functional Force Measures

    OpenAIRE

    Jacobs, Cale A; Christensen, Christian P

    2009-01-01

    Subjective evaluations often are used after knee arthroplasty to quantify function; however, these scores may be influenced by pain and/or function of the nonoperated limb. Multiple influences increase variability of these scores, which in turn may result in a greater change in score required to be considered clinically important. We determined the relationships among the Knee Society pain and function scores, range of motion (ROM), and functional force measures of the surgically treated and ...

  6. Estimates of genetic parameters for visual scores and their correlation with production and reproductive traits in Brahman cattle

    Scientific Electronic Library Online (English)

    Tássia Souza, Bertipaglia; Luis Orlando Duitama, Carreño; Carlos Henrique Cavallini, Machado; Cristiana, Andrighetto; Ricardo da, Fonseca.

    2012-06-01

    Full Text Available The objective of this study was to evaluate the association of visual scores of body structure, precocity and muscularity with production (body weight at 18 months and average daily gain) and reproductive (scrotal circumference) traits in Brahman cattle in order to determine the possible use of thes [...] e scores as selection criteria to improve carcass quality. Covariance components were estimated by the restricted maximum likelihood method using an animal model that included contemporary group as fixed effect. A total of 1,116 observations of body structure, precocity and muscularity were used. Heritability was 0.39, 043 and 0.40 for body structure, precocity and muscularity, respectively. The genetic correlations were 0.79 between body structure and precocity, 0.87 between body structure and muscularity, and 0.91 between precocity and muscularity. The genetic correlations between visual scores and body weight at 18 months were positive (0.77, 0.57 and 0.59 for body structure, precocity and muscularity, respectively). Similar genetic correlations were observed between average daily gain and visual scores (0.60, 0.57 and 0.48, respectively), whereas the genetic correlations between scrotal circumference and these scores were low (0.13, 0.02, and 0.13). The results indicate that visual scores can be used as selection criteria in Brahman breeding programs. Favorable correlated responses should be seen in average daily gain and body weight at 18 months. However, no correlated response is expected for scrotal circumference.

  7. Correlation of Pain Scores, Analgesic Use, and Beck Anxiety Inventory Scores During Hospitalization in Lower Extremity Amputees

    OpenAIRE

    Trame, Cathy D; Greene, Erin; Moddeman, Gail; Booth, Branyan A; Konstantakos, Emmanuel K; Parada, Stephen; Siebuhr, Karl; Laughlin, Richard T.

    2008-01-01

    Post amputation pain can be debilitating for patients and families. Chronic pain is a common phenomenon after lower extremity amputation, occurring in up to 80% of this population. The purpose of this pilot study was to correlate post amputation pain scores to opioid analgesic consumption and Beck Anxiety Inventory (BAI) scores. Twenty-three patients with lower extremity amputation at an 827-bed acute care inner-city hospital were surveyed pre-operatively and post-operatively to determine if ...

  8. Correlation of the score for subjective pain with physical disability, clinical and radiographic scores in recent onset rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Turiel Maurizio

    2002-07-01

    Full Text Available Abstract Background To analyse the relationship between subjective pain score and other measures of clinical, radiographic and functional status; in particular Larsen radiographic scores and Health Assessment Questionnaire (HAQ; in patients with severe rheumatoid arthritis (RA with a disease duration of less than 3 years. Methods In this cross sectional study of 105 patients with RA (76 women, 29 men: mean age 50.93; mean disease duration 15.86 months; 71% rheumatoid factor positive subjective pain was assessed according to the Visual Analog Scale (VAS. Correlation coefficients between pain score and disease activity measures (patients' global assessment of disease by VAS, number of tender and swollen joints, morning stiffness, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP] and titre of rheumatoid factor, radiographic evaluations (Larsen-Dale scores for radiographic damage of the small joints of the hands, wrist and feet, disability measures (health assessment questionnaire [HAQ], and demographic variables were calculated; hierarchical regression analysis was done with subjective pain score as the dependent variable. Results The Spearman's correlation coefficient comparing subjective pain and HAQ was 0.421 (p 0.05. In regression analysis, global assessment of disease by patients explained 32.8% of the variation in pain intensity score, morning stiffness 10.7%, CRP 4.0%, HAQ 3.8% and Larsen-Dale scores explained 2.1%; other variables were not significant in the model. Conclusions Pain scores of patients with early severe rheumatoid arthritis are correlated at higher levels with patients' global assessment of disease and with morning stiffness rather than with radiographic or other clinical variables such as number of tender and swollen joints.

  9. Diagnostic accuracy of modified kenneth jones scoring criteria (mkjsc) in confirmed cases of tuberculosis in children

    International Nuclear Information System (INIS)

    Background: Tuberculosis (TB) is a granulomatous disease caused by Mycobacterium tuberculosis. The gold standard for the diagnosis of tuberculosis is detection of Mycobacterium tubercle bacilli. However, clinical scoring systems are most widely used for the diagnosis of TB in children. Objective: To determine the diagnostic accuracy of modified Kenneth Jones scoring criteria (MKJSC) in conformed cases of tuberculosis. Methodology: This cross-sectional comparative study was conducted in the department of Paediatrics, King Edward Medical University / Mayo Hospital, Lahore from January to June 2007. One hundred children below 15 years of age were enrolled. They were diagnosed as suspected cases of TB on the basis of fever and cough for more than 15 days. MKJSC was applied and each child was subjected to confirmatory test for TB. Results: There was an overall male preponderance of 54%. The mean age of study population was 1.8 +- 0.7 years. Out of 100 children, 66% were diagnosed as TB cases (23 with confirmatory tests and 43 with MKJSC of 5 or more). Sensitivity, specificity, positive and negative predictive value of MKJSC was 73.91%, 44.16%, 28.33%, and 85% respectively. Diagnostic accuracy of MKJSC was 51%. Conclusion: Present study does not support the hypothesis that MKJSC is a good alternative to confirmatory tests to diagnose tuberculosis in children. However, MKJSC is a simple tool, which can be applied to improve the case detection rate in the absence of sophisticated tests. (author)

  10. A Comparison of Brunt Criteria, the Non Alcoholic Fatty Liver Disease Activity Score (NAS) & a Proposed NAS-including fibrosis as Valid Diagnostic Scores for NASH

    Science.gov (United States)

    Santiago-Rolón, Amarilys; Purcell, Dagmary; Rosado, Kathia; Toro, Doris H.

    2016-01-01

    Objective Non-alcoholic steatohepatitis (NASH) can result in cirrhosis and end stage liver disease. It is of utmost importance to differentiate NASH from simple steatosis. The aim of this study is to determine the prevalence of NASH in Latino veterans with metabolic syndrome and compare histologic grading using Brunt Criteria, the NAFLD activity score (NAS), and a proposed NAS score including fibrosis. Methods Veterans with metabolic syndrome, hepatic steatosis and elevation of ALT/AST who underwent a liver biopsy from 2004-2010 were included in this study. Biopsies were evaluated by a single blinded Hepatopathologist. Steatosis, lobular inflammation, ballooning and fibrosis were graded per specimen. Each biopsy was evaluated using Brunt criteria, NAS and NAS plus fibrosis. Results Sixty patients were included in this study, 88.3% men with a mean age of 50.4 (± 12.8). 50.0% met criteria for NASH according to the Brunt system. When classifying biopsies using NAS, only 30.0% (18/60) had a score ?5, while when adding fibrosis, the number of patients with a score ?5 increased to 33 (55.0%). When evaluating the predictive ability of the two scoring systems, we found that NAS including fibrosis had a higher sensitivity than NAS (86.7% vs. 40.0%) and a lower specificity (76.7% vs. 80.0%). Conclusion In our population with metabolic syndrome and altered liver function tests, about 50-55% had steatohepatitis. There were significant differences between the scoring systems. When using NAS-plus-fibrosis more patients were recognized and the sensitivity increased. Further validation studies are required to evaluate this proposed NAS scoring System. PMID:26602577

  11. Apparent diffusion coefficient ratio correlates significantly with prostate cancer gleason score at final pathology

    DEFF Research Database (Denmark)

    Boesen, Lars; Chabanova, Elizaveta

    2015-01-01

    PURPOSE: To evaluate the correlation between apparent diffusion coefficient measurements (ADCtumor and ADCratio ) and the Gleason score from radical prostatectomy specimens. MATERIALS AND METHODS: Seventy-one patients with clinically localized prostate cancer scheduled for radical prostatectomy were prospectively enrolled. Multiparametric magnetic resonance imaging (MRI) was performed prior to prostatectomy and mean ADC values from both cancerous (ADCtumor ) and benign (ADCbenign ) tissue were measured to calculate the ADCratio (ADCtumor divided by ADCbenign ). The ADC measurements were correlated with the Gleason score from the prostatectomy specimens. RESULTS: The association between ADC measurements and Gleason score showed a significant negative correlation (P?score for all tumors (P?=?0.001). Receiver operating characteristic curve analysis showed an overall area under the curve (AUC) of 0.73 (ADCtumor ) to 0.80 (ADCratio ) in discriminating Gleason score 6 from Gleason score ?7 tumors. The AUC changed to 0.72 (ADCtumor ) and 0.90 (ADCratio ) when discriminating Gleason score ?7(3+4) from Gleason score ?7(4+3). CONCLUSION: ADC measurements showed a significant correlation with tumor Gleason score at final pathology. The ADCratio demonstrated the best correlation compared to the ADCtumor value and radically improved accuracy in discriminating Gleason score ?7(3+4) from Gleason score ?7(4+3) tumors. J. Magn. Reson. Imaging 2014.

  12. Automatic Evaluation of Machine Translation : Correlating Post-editing Effort and Translation Edit Rate (TER) Scores

    DEFF Research Database (Denmark)

    Martinez, Mercedes Garcia; Koglin, Arlene

    2015-01-01

    The availability of systems capable of producing fairly accurate translations has increased the popularity of machine translation (MT). The translation industry is steadily incorporating MT in their workflows engaging the human translator to post-edit the raw MT output in order to comply with a set of quality criteria in as few edits as possible. The quality of MT systems is generally measured by automatic metrics, producing scores that should correlate with human evaluation.In this study, we investigate correlations between one of such metrics, i.e. Translation Edit Rate (TER), and actual post-editing effort as it is shown in post-editing process data collected under experimental conditions. Using the CasMaCat workbench as a post-editing tool, process data were collected using keystrokes and eye-tracking data from five professional translators under two different conditions: i) traditional post-editing and ii) interactive post-editing. In the second condition, as the user types, the MT system suggests alternative target translations which the post-editor can interactively accept or overwrite, whereas in the first condition no aids are provided to the user while editing the raw MT output. Each one of the five participants was asked to post-edit 12 different texts using the interactivity provided by the system and 12 additional texts without interactivity (i.e. traditional post-editing) over a period of 6 weeks.Process research in post-editing is often grounded on three different but related categories of post-editing effort, namely i) temporal (time), ii) cognitive (mental processes) and iii) technical (keyboard activity). For the purposes of this research, TER scores were correlated with two different indicators of post-editing effort as computed in the CRITT Translation Process Database (TPR-DB) *. On the one hand, post-editing temporal effort was measured using FDur values (duration of segment production time excluding keystroke pauses >_200 seconds) and KDur values (duration of coherent keyboard activity excluding keystroke pauses >_ 5 seconds). On the other hand, post-editing technical effort was measured using Mdel values (number of manually generated deletions) and Mins values (number of manually generated insertions).Results show that TER scores have a positive correlation with actual post-editing effort as reflected in the form of manual insertions and deletions (Mins/Mdel) as well as time to perform the task (KDur/FDur).

  13. Automatic sleep scoring in normals and in individuals with neurodegenerative disorders according to new international sleep scoring criteria

    DEFF Research Database (Denmark)

    Jensen, Peter S; Sorensen, Helge B D; Jennum, Poul; Leonthin, Helle

    2010-01-01

    Parkinson disease or multiple system atrophy. This led to quantification of automatic versus manual epoch-by-epoch agreement rates for both normals and abnormals. Resulting average agreement rates were 87.7% (Cohen's Kappa: 0.79) and 68.2% (Cohen's Kappa: 0.26) in the normal and abnormal group, respectively...... reliability, it failed in accurately scoring abnormal sleep as encountered for the Parkinson disease/multiple system atrophy patients....

  14. The correlative analysis between volume measurement by SPECT and the clinical scoring in cerebral infarction

    International Nuclear Information System (INIS)

    The reliability of the clinical scoring system by the volume measurement of cerebral infarction with SPECT was assessed. The volume measurement of left and right brain in 20 healthy subjects was used as control. We studied the correlations between the volume of infarcted lesion measured by SPECT and two kinds of clinical scoring system in 31 patients who suffered from simple unilateral cerebral infarction. The correlation coefficient between volume and score was 0.631?0.795 (P<0.001). The coincidence rate was rather good. SPECT study has objectively showed that these 2 kinds of clinical scoring system are quite reliable

  15. Ultrafast CT scoring system for assessing bronchopulmonary dysplasia. Reproducibility and clinical correlation

    International Nuclear Information System (INIS)

    To evaluate the reproducibility of the Ultrafast CT (UFCT) scoring system and assess its usefulness in monitoring clinical severity in infants with bronchopulmonary dysplasia (BPD). UFCT scoring was done in 22 infants (15 boys and 7 girls aged 1 to 37 months) with BPD. A total of 258 lung fields were evaluated for the presence of hyperaeration, linear opacities, triangular subpleural opacities, and bronchovascular bundle distortion or thickening, and UFCT scores were given. Intraobserver and interobserver agreement and reproducibility of UFCT scores were statistically analyzed. In 12 patients, UFCT scores were linearly correlated with clinical severity scores based on respiratory dysfunction and complexity of care. 'Hyperaeration,' which was the most frequent (18 of 22, 81.8%) finding, showed high concordance (?=0.73, p<0.001, ?=0.59, p<0.001), and its UFCT scores significantly correlated with intraobserver and interobserver analyses (r=0.94, p<0.001, r=0.82, p<0.001, respectively). UFCT scores for hyperaeration significantly correlated with clinical scores (r=0.75, p<0.01), whereas those for the others did not. UFCT is useful for assessing BPD. Hyperaeration was the most common and reproducible finding, and its extent significantly correlated with clinical severity. (author)

  16. Anomalous Diffusion and Long-range Correlations in the Score Evolution of the Game of Cricket

    CERN Document Server

    Ribeiro, H V; Zeng, Xiao Han T

    2012-01-01

    We investigate the time evolution of the scores of the second most popular sport in world: the game of cricket. By analyzing the scores event-by-event of more than two thousand matches, we point out that the score dynamics is an anomalous diffusive process. Our analysis reveals that the variance of the process is described by a power-law dependence with a super-diffusive exponent, that the scores are statistically self-similar following a universal Gaussian distribution, and that there are long-range correlations in the score evolution. We employ a generalized Langevin equation with a power-law correlated noise that describe all the empirical findings very well. These observations suggest that competition among agents may be a mechanism leading to anomalous diffusion and long-range correlation.

  17. Beyond Correlations: Usefulness of High School GPA and Test Scores in Making College Admissions Decisions

    Science.gov (United States)

    Sawyer, Richard

    2013-01-01

    Correlational evidence suggests that high school GPA is better than admission test scores in predicting first-year college GPA, although test scores have incremental predictive validity. The usefulness of a selection variable in making admission decisions depends in part on its predictive validity, but also on institutions' selectivity and…

  18. Correlations Between Chiropractic National Board (Part I) Scores and Basic Science Course Grades and Related Data.

    Science.gov (United States)

    Wolfenberger, Virginia

    1999-01-01

    A study at one institution found significant correlations between students' scores on the National Board of Chiropractic Examiners test and academic achievement data. Results indicate that it is not always course subject matter that influences the relationship between course grade and board scores, but may instead be the ability to assimilate…

  19. Correlation Between Students' Dental Admission Test Scores and Performance on a Dental School's Competency Exam.

    Science.gov (United States)

    Carroll, Alexander M; Schuster, Gregory M

    2015-11-01

    The aim of this study was to investigate whether there was a statistically significant positive correlation between dental students' Dental Admission Test (DAT) scores, particularly on the Perceptual Ability Test (PAT), and their performance on a dental school's competency exam. Scores from the written and clinical competency exam administered in the fall quarter of the fourth year of the curriculum at Midwestern University College of Dental Medicine-Arizona were compared to DAT scores of all 216 members of the graduating classes of 2012 and 2013. It was hypothesized that students who performed highly on one or more sections of the DAT would perform highly on the competency exam. Backward stepwise regression analyses were used to analyze the data. The results showed that the PAT scores were most strongly correlated with the competency exam scores and were a positive predictor for all three clinical sections of the exam (operative dentistry, periodontics, and endodontics). Positive predictors for the written portion of the exam were total DAT score for patient assessment and treatment planning and the DAT reading comprehension score for prosthodontics; there were no predictors for periodontics. The total variance explained by the results ranged from 4% to 15%. While statistically significant relationships were found between the students' PAT scores and clinical performance, DAT scores explained relatively little variance in the competency exam scores. According to these findings, neither the PAT nor any of the DAT components contributed to predicting these students' clinical performance. PMID:26522638

  20. High resolution CT in children with cystic fibrosis: correlation with pulmonary functions and radiographic scores

    International Nuclear Information System (INIS)

    Objective: To compare the high resolution CT (HRCT) scores of the Bhalla system with pulmonary function tests and radiographic and clinical points of the Shwachman-Kulczycki clinical scoring system. Methods: HRCT of the chest was obtained in 40 children to assess the role of HRCT in evaluating bronchopulmonary pathology in children with cystic fibrosis (CF). The HRCT severity scores of the Bhalla system were compared with chest radiographic and clinical points of the Shwachman-Kulczycki scoring system and pulmonary function tests. Only 14 of the patients older than 6 years cooperated with spirometry. Results: HRCT scores correlated well with radiographic points (r=0.80, P1 (r=0.66, P=0.01). Although radiographic points correlated significantly with FVC (r=0.61, P=0.02) and FEV1 (r=0.56, P=0.04), HRCT provides a more precise scoring than the chest X-ray. Conclusion: The HRCT scoring system may provide a sensitive method of monitoring pulmonary disease status and may replace the radiographic scoring in the Shwachman-Kulczycki system. It may be helpful especially in follow-up of small children too young to cooperate with spirometry

  1. High resolution CT in children with cystic fibrosis: correlation with pulmonary functions and radiographic scores

    Energy Technology Data Exchange (ETDEWEB)

    Demirkazik, Figen Basaran E-mail: demirkaz@dialup.ankara.edu.tr; Ariyuerek, O. Macit; Oezcelik, Ugur; Goecmen, Ayhan; Hassanabad, Hossein K.; Kiper, Nural

    2001-01-01

    Objective: To compare the high resolution CT (HRCT) scores of the Bhalla system with pulmonary function tests and radiographic and clinical points of the Shwachman-Kulczycki clinical scoring system. Methods: HRCT of the chest was obtained in 40 children to assess the role of HRCT in evaluating bronchopulmonary pathology in children with cystic fibrosis (CF). The HRCT severity scores of the Bhalla system were compared with chest radiographic and clinical points of the Shwachman-Kulczycki scoring system and pulmonary function tests. Only 14 of the patients older than 6 years cooperated with spirometry. Results: HRCT scores correlated well with radiographic points (r=0.80, P<0.0001) and clinical points (r=0.67, P<0.0001) of the Shwachman-Kulczycki system, FVC (r=0.71 P=0.004) and FEV{sub 1} (r=0.66, P=0.01). Although radiographic points correlated significantly with FVC (r=0.61, P=0.02) and FEV{sub 1} (r=0.56, P=0.04), HRCT provides a more precise scoring than the chest X-ray. Conclusion: The HRCT scoring system may provide a sensitive method of monitoring pulmonary disease status and may replace the radiographic scoring in the Shwachman-Kulczycki system. It may be helpful especially in follow-up of small children too young to cooperate with spirometry.

  2. Attenuation of the Squared Canonical Correlation Coefficient under Varying Estimates of Score Reliability

    Science.gov (United States)

    Wilson, Celia M.

    2010-01-01

    Research pertaining to the distortion of the squared canonical correlation coefficient has traditionally been limited to the effects of sampling error and associated correction formulas. The purpose of this study was to compare the degree of attenuation of the squared canonical correlation coefficient under varying conditions of score reliability.…

  3. Correlation of fracture index with BMD T score in postmenopausal females

    International Nuclear Information System (INIS)

    Objective: To find the correlation between fracture index and BMD T-score so that fracture index can be used as a predictive tool for fracture risk estimation in post menopausal females. Design: A cross-sectional study was conducted on a sample of 396 women age 50 years and above. BMD T-score measurements using ultrasound and fracture index calculation based on the risk factor assessment were performed. Results: The study results showed that when fracture index increases BMD T-score decreased to osteoporotic range and correlation coefficient is -0.162. Conclusion: When fracture index increases, BMD T-score decreases therefore we can use fracture index as an assessment tool for predicting fracture risk in postmenopausal females. (author)

  4. MR imaging of acute pancreatitis: Correlation of abdominal wall edema with severity scores

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Ru, E-mail: yangru0904@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Jing, Zong Lin, E-mail: jzl325@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Zhang, Xiao Ming, E-mail: zhangxm@nsmc.edu.cn [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Tang, Wei, E-mail: tw-n-g-up@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Xiao, Bo, E-mail: xiaoboimaging@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Huang, Xiao Hua, E-mail: nc_hxh1966@yahoo.com.cn [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Yang, Lin, E-mail: llinyangmd@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Feng, Zhi Song, E-mail: fengzhisong@medmail.com.cn [Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China)

    2012-11-15

    Objective: To study MRI findings of abdominal wall edema (AWE) in acute pancreatitis as well as correlations between AWE and the severity of acute pancreatitis according to the MR severity index (MRSI) and the Acute Physiology And Chronic Healthy Evaluation III (APACHE III) scoring system. Materials and methods: A total of 160 patients with AP admitted to our institution between December 2009 and March 2011 were included in this study. MRI was performed within 48 h after admission. MRI findings of acute pancreatitis were noted, including AWE on the MRI. The abdominal wall area was divided into quarters, and each area involved was recorded as 1 point to score the severity of AWE. The severity of acute pancreatitis was studied using both the MRSI and the APACHE III scoring system. Spearman correlation of AWE with the MRSI and the APACHE III scoring system was analyzed. Results: In 160 patients with acute pancreatitis, 53.8% had AWE on MRI. The average AWE score was 1.2 {+-} 1.4 points. The prevalence of AWE was 30.5%, 64.5% and 100% in mild, moderate and severe AP, respectively, according to MRSI. AWE on MRI was correlated with MRSI scores (r = 0.441, p = 0.000). According to APACHE III scores, the averages were 2.0 {+-} 1.1 and 2.6 {+-} 1.1 points in mild AP and severe AP, respectively (P = 0.016). AWE was slightly correlated with the APACHE III scores (r = 0.222, p = 0.005). Conclusion: AWE on MRI in acute pancreatitis is common, which may be a supplementary indicator in determining the severity of AP.

  5. MR imaging of acute pancreatitis: Correlation of abdominal wall edema with severity scores

    International Nuclear Information System (INIS)

    Objective: To study MRI findings of abdominal wall edema (AWE) in acute pancreatitis as well as correlations between AWE and the severity of acute pancreatitis according to the MR severity index (MRSI) and the Acute Physiology And Chronic Healthy Evaluation III (APACHE III) scoring system. Materials and methods: A total of 160 patients with AP admitted to our institution between December 2009 and March 2011 were included in this study. MRI was performed within 48 h after admission. MRI findings of acute pancreatitis were noted, including AWE on the MRI. The abdominal wall area was divided into quarters, and each area involved was recorded as 1 point to score the severity of AWE. The severity of acute pancreatitis was studied using both the MRSI and the APACHE III scoring system. Spearman correlation of AWE with the MRSI and the APACHE III scoring system was analyzed. Results: In 160 patients with acute pancreatitis, 53.8% had AWE on MRI. The average AWE score was 1.2 ± 1.4 points. The prevalence of AWE was 30.5%, 64.5% and 100% in mild, moderate and severe AP, respectively, according to MRSI. AWE on MRI was correlated with MRSI scores (r = 0.441, p = 0.000). According to APACHE III scores, the averages were 2.0 ± 1.1 and 2.6 ± 1.1 points in mild AP and severe AP, respectively (P = 0.016). AWE was slightly correlated with the APACHE III scores (r = 0.222, p = 0.005). Conclusion: AWE on MRI in acute pancreatitis is common, which may be a supplementary indicator in determining the severity of AP.

  6. Correlated physical and mental health summary scores for the SF-36 and SF-12 Health Survey, V.1

    Directory of Open Access Journals (Sweden)

    Cunningham William E

    2007-09-01

    Full Text Available Abstract Background The SF-36 and SF-12 summary scores were derived using an uncorrelated (orthogonal factor solution. We estimate SF-36 and SF-12 summary scores using a correlated (oblique physical and mental health factor model. Methods We administered the SF-36 to 7,093 patients who received medical care from an independent association of 48 physician groups in the western United States. Correlated physical health (PCSc and mental health (MCSc scores were constructed by multiplying each SF-36 scale z-score by its respective scoring coefficient from the obliquely rotated two factor solution. PCSc-12 and MCSc-12 scores were estimated using an approach similar to the one used to derive the original SF-12 summary scores. Results The estimated correlation between SF-36 PCSc and MCSc scores was 0.62. There were far fewer negative factor scoring coefficients for the oblique factor solution compared to the factor scoring coefficients produced by the standard orthogonal factor solution. Similar results were found for PCSc-12, and MCSc-12 summary scores. Conclusion Correlated physical and mental health summary scores for the SF-36 and SF-12 derived from an obliquely rotated factor solution should be used along with the uncorrelated summary scores. The new scoring algorithm can reduce inconsistent results between the SF-36 scale scores and physical and mental health summary scores reported in some prior studies. (Subscripts C = correlated and UC = uncorrelated

  7. Correlated physical and mental health summary scores for the SF-36 and SF-12 Health Survey, V.1

    Science.gov (United States)

    Farivar, Sepideh S; Cunningham, William E; Hays, Ron D

    2007-01-01

    Background The SF-36 and SF-12 summary scores were derived using an uncorrelated (orthogonal) factor solution. We estimate SF-36 and SF-12 summary scores using a correlated (oblique) physical and mental health factor model. Methods We administered the SF-36 to 7,093 patients who received medical care from an independent association of 48 physician groups in the western United States. Correlated physical health (PCSc) and mental health (MCSc) scores were constructed by multiplying each SF-36 scale z-score by its respective scoring coefficient from the obliquely rotated two factor solution. PCSc-12 and MCSc-12 scores were estimated using an approach similar to the one used to derive the original SF-12 summary scores. Results The estimated correlation between SF-36 PCSc and MCSc scores was 0.62. There were far fewer negative factor scoring coefficients for the oblique factor solution compared to the factor scoring coefficients produced by the standard orthogonal factor solution. Similar results were found for PCSc-12, and MCSc-12 summary scores. Conclusion Correlated physical and mental health summary scores for the SF-36 and SF-12 derived from an obliquely rotated factor solution should be used along with the uncorrelated summary scores. The new scoring algorithm can reduce inconsistent results between the SF-36 scale scores and physical and mental health summary scores reported in some prior studies. (Subscripts C = correlated and UC = uncorrelated) PMID:17825096

  8. Correlation between Umbilical Cord pH and Apgar Score in High-Risk Pregnancy

    OpenAIRE

    Mahmood Hajiahmadi; Maryam Javadian; Nesa Asnafi1; Mousa Ahmadpour-Kacho; Nazila Hosseini Taleghani

    2010-01-01

    Objective:The Apgar score as a proven useful tool for rapid assessment of the neonate is often poorly correlated with other indicators of intrapartum neonatal well-being. This study was carried out to determine the correlation between umbilical cord pH and Apgar score in high-risk pregnancies. Methods:This is a prospective cross-sectional, analytic study performed on 96 mother-fetal pairs during 2004-2005 at Shahid Yahyanejad hospital, which is affiliated to Babol University of Medical Scienc...

  9. STUDY OF CORRELATION OF MODIFIED ALAVARADO SCORING WITH HISTOPATHOLOGY AND EARLY POST OPERATIVE COMPLICATIONS

    Directory of Open Access Journals (Sweden)

    Rajanna

    2014-11-01

    Full Text Available Appendicitis being the commonest acute abdominal surgical condition, although diagnosis can be made clinically but possess diagnostic difficulty to junior surgeons. The need for appropriate tool/scoring system that can be easily applicable, accurate & reproducible in the diagnosis of appendicitis is essential to have a low negative Appendicectomy rate. This prospective study is designed to assess one such scoring system, i.e., Modified Alvarado Score. MATERIALS AND METHODS: SETTING AND DURATION: Department of Surgery, Hassan Institute of Medical Sciences/Teaching Hospital, Hassan. From August 2013 to September 2014. A total of 227 consecutive male and female patients with age above 14 years presenting with right lower abdominal pain were enrolled in this study, analysed according to eight variables of Modified Alvarado scoring system and were accordingly placed into 3 groups. Group–I patients having score 1–4 were discharged, Group-II patients having score 5–6 were observed, while Group-III patients having score 7–10 were operated and all the operated patients were followed up for 30 days. These groups were compared with intra-operative findings, histopathological results & early post –operative complications. RESULTS: Of the total 227 patients included in this study, 155 underwent Appendicectomy based on the Modified Alvarado scoring system. Out of 155 operated patients 142(91.6% had acute appendicitis, thus yielding a positive predictive value of 91.6% while negative appendicectomy rate 9.3%. Frequency of negative appendicectomy was 5.3% (5/94 among males and 9.4% (08/61 in females. Post-operative complication rate including wound infection, pelvic abscess, chest and urinary tract infection was 10.3% (16/155. CONCLUSION: The present study showed that Alvarado clinical scoring system has a high diagnostic value of 90%. Alvarado scoring system is dynamic one & its proper application improves diagnostic accuracy. There by reduce the rate of negative appendicectomy, anticipate the post-operative stay & complications. In acute appendicitis, modified Alvarado scoring can be used as an objective criteria for selection of patient for appropriate Medical or Surgical treatment. This scoring system is easy, simple and cheap complementary aid for supporting the diagnosis of acute appendicitis especially for junior surgeons

  10. Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects

    OpenAIRE

    Li Wentian; Han Zhihua; Ulgen Ayse

    2003-01-01

    Abstract Background We address the question of whether statistical correlations among quantitative traits lead to correlation of linkage results of these traits. Five measured quantitative traits (total cholesterol, fasting glucose, HDL cholesterol, blood pressure, and triglycerides), and one derived quantitative trait (total cholesterol divided by the HDL cholesterol) are used for phenotype correlation studies. Four of them are used for linkage analysis. Results We show that although correla...

  11. High PCA3 scores in urine correlate with poor-prognosis factors in prostate cancer patients

    Science.gov (United States)

    Wei, Wei; Leng, Jiangyong; Shao, Hongxiang; Wang, Weidong

    2015-01-01

    Background: To improve the prediction of prostate cancer (PCA) risk and pathological type of PCA by non-invasive approaches before performing prostatic biopsy are the current challenges for the management of PCA. The aim of this present study was evaluate the clinical validity of prostate cancer associated 3 (PCA3) gene in the prediction of PCA and the correlations between the PCA3 level and prognostic factors. Methods: A total of 207 patients with suspected prostate cancer in Ningbo No. 2 hospital between June 2012 and July 2014 were enrolled in this study. All patients included underwent prostate biopsy under the direction of digital rectal examination (DRE) and were divided into PCA group and no evidence of malignancy (NEM) group according to the pathological diagnosis. We analyzed the association between PCA3 score and indicators of prognosis (Gleason score, percentage of positive cores and clinical stage) by multivariate analysis. Results: The levels of total prostate-specific antigen (t-PSA), prostate health index (PHI) and PCA3 score in patients with PCA were significantly higher than those in NEM group (P<0.05). In PCA group, PHI value and t-PSA were both factors significantly correlated with high Gleason score and clinical stage (P<0.05). A high PCA3 score in urine was significantly correlated with a high Gleason score, % positive cores and an advanced clinical stage (P<0.05). Conclusion: PCA3 score might be one of useful diagnostic tools for determining suitable therapeutic programs for PCa and predicting the prognosis.

  12. THE INFLUENCE OF PRIOR EXPERIENCE ON THE CONSTRUCTION OF SCORING CRITERIA FOR ESL COMPOSITIONS: A CASE STUDY

    Directory of Open Access Journals (Sweden)

    M. Usman Erdosy

    2001-12-01

    Full Text Available Before a principled explanation of variability in raters' judgements of ESL compositions can be offered, the process of constructing scoring criteria and the manner in which prior experience enters this process must be analyzed. Therefore, utilizing protocol and intewiew data collected in the context of a comparative study, a case study will describe how one experienced rater dealt with the following operations while assessing a corpus of 60 TOEFL essays: establishing the purpose of assessment, developing a reading strategy to deal with a corpus of essays, and collecting context-specific information. Within each operation, the influence of background variables such as teaching and assessment experience will be examined, particularly on determining what type of information to collect, and on articulating expectations concerning test takers, test scores and the textual qualities of essays. The results of the study will be used to specific directions for future research into explaining inter-rater variability.

  13. Genetic correlations among body condition score, yield and fertility in multiparous cows using random regression models

    OpenAIRE

    Bastin, Catherine; Gillon, Alain; Massart, Xavier; Bertozzi, Carlo; Vanderick, Sylvie; Gengler, Nicolas

    2010-01-01

    Genetic correlations between body condition score (BCS) in lactation 1 to 3 and four economically important traits (days open, 305-days milk, fat, and protein yields recorded in the first 3 lactations) were estimated on about 12,500 Walloon Holstein cows using 4-trait random regression models. Results indicated moderate favorable genetic correlations between BCS and days open (from -0.46 to -0.62) and suggested the use of BCS for indirect selection on fertility. However, unfavorable genetic c...

  14. Apparent diffusion coefficient ratio correlates significantly with prostate cancer gleason score at final pathology

    DEFF Research Database (Denmark)

    Boesen, Lars; Chabanova, Elizaveta; Løgager, Vibeke; Balslev, Ingegerd; Thomsen, Henrik S

    2015-01-01

    PURPOSE: To evaluate the correlation between apparent diffusion coefficient measurements (ADCtumor and ADCratio ) and the Gleason score from radical prostatectomy specimens. MATERIALS AND METHODS: Seventy-one patients with clinically localized prostate cancer scheduled for radical prostatectomy were prospectively enrolled. Multiparametric magnetic resonance imaging (MRI) was performed prior to prostatectomy and mean ADC values from both cancerous (ADCtumor ) and benign (ADCbenign ) tissue were m...

  15. Correlations of visual scores, carcass traits, feed efficiency and retail product yield in Nellore cattle

    Scientific Electronic Library Online (English)

    Paulo Henrique, Cancian; Rodrigo da Costa, Gomes; Fernando Ricardo, Manicardi; Andrea Cristina, Ianni; Marina de Nadai, Bonin; Paulo Roberto, Leme; Saulo da Luz e, Silva.

    2014-02-01

    Full Text Available The growing use of visual scores (VS) and ultrasound (US) for carcass evaluation in breeding programs, calls for a knowledge of the relationships between these traits and other relevant characteristics, such as feed efficiency and production of commercial cuts. The objective of this study was to eva [...] luate correlations between body visual scores and carcass traits identified by ultrasound (US) and feed efficiency (FE), carcass weight (HCW), dressing percentage (DP) and retail product yield (RPY) in beef cattle. Nellore cattle (male), 42 non-castrated [NCAST] and 44 castrated [CAST]) were evaluated by both VS and US, at the postweaning (15-month old) and finishing phases (21-month old). Visual scores of conformation (C), precocity (P) and muscling (M) were assessed and the backfat thickness (UBFT), rump fat thickness (URFT) and ribeye area (UREA) were measured by ultrasound. Gain-to-feed (G:F) ratio and residual feed intake (RFI) were measured in feedlot. Hot carcass weight, DP and RPY were determined at harvest. Non-castrated cattle had greater HCW and RPY but lower UBFT and URFT than CAST. Postweaning VS and US were poorly correlated with FE in both sexual conditions. Finishing VS were negatively correlated with G:F in CAST and finishing URFT was negatively correlated with RPY in NCAST. The relationship of VS and US with feed efficiency and meat yield is affected by age at the date of evaluation and by castration. Feed efficiency is not related to the yield of meat cuts in Nellore cattle

  16. Do hospital-acquired condition scores correlate with patients' perspectives of care?

    Science.gov (United States)

    Menendez, Mariano E; Ring, David

    2015-01-01

    Beginning in fiscal year 2015, the federal Hospital-Acquired Condition (HAC) Reduction Program requires the Centers for Medicare & Medicaid Services to reduce payments by 1% for hospitals in the top quartile of risk-adjusted national HAC scores. The HAC penalty underscores the need for hospitals to become increasingly quality- and safety-focused, which could negatively affect their performance on patient satisfaction with care, another key performance metric tied to reimbursement. Using publicly available data through the Centers for Medicare & Medicaid Services Hospital Compare program, we assessed the correlation between preliminary HAC scores and patients' perspectives of care, as measured by the Hospital Consumer Assessment of Healthcare Providers and Systems survey. Higher quality of care (lower HAC score) was modestly associated with a better patient experience (r = -0.090, P satisfaction. PMID:25830614

  17. PASI and PQOL-12 score in psoriasis : Is there any correlation?

    Directory of Open Access Journals (Sweden)

    Vikas Shankar

    2011-01-01

    Full Text Available Background: Psoriasis, a common papulo-squamous disorder of the skin, is universal in occurrence and may interfere with the quality of life adversely. Whether extent of the disease has any bearing upon the patients′ psychology has not much been studied in this part of the world. Aims: The objective of this hospital-based cross-sectional study was to assess the disease severity objectively using Psoriasis area and severity index (PASI score and the quality of life by Psoriasis quality-of-life questionnaire-12 (PQOL-12 and to draw correlation between them, if any. Materials and Methods PASI score denotes an objective method of scoring severity of psoriasis, reflecting not only the body surface area but also erythema, induration and scaling. The PQOL-12 represents a 12-item self-administered, disease-specific psychometric instrument created to specifically assess quality-of-life issues that are more important with psoriasis patients. PASI and PQOL-12 score were calculated in each patient for objectively assessing their disease severity and quality of life. Results: In total, 34 psoriasis patients (16 males, 18 females, of age ranging from 8 to 55 years, were studied. Maximum and minimum PASI scores were 0.8 and 32.8, respectively, whereas maximum and minimum PQOL-12 scores were 4 and 120, respectively. PASI and PQOL-12 values showed minimal positive correlation (r = +0.422. Conclusion: Disease severity of psoriasis had no direct reflection upon their quality of life. Limited psoriasis on visible area may also have greater impact on mental health.

  18. Prostate cancer staging with extracapsular extension risk scoring using multiparametric MRI : a correlation with histopathology

    DEFF Research Database (Denmark)

    Boesen, Lars; Chabanova, Elizaveta

    2015-01-01

    OBJECTIVES: To evaluate the diagnostic performance of preoperative multiparametric MRI with extracapsular extension (ECE) risk-scoring in the assessment of prostate cancer tumour stage (T-stage) and prediction of ECE at final pathology. MATERIALS AND METHODS: Eighty-seven patients with clinically localised prostate cancer scheduled for radical prostatectomy were prospectively enrolled. Multiparametric MRI was performed prior to prostatectomy, and evaluated according to the ESUR MR prostate guidelines by two different readers. An MRI clinical T-stage (cTMRI), an ECE risk score, and suspicion of ECE based on tumour characteristics and personal opinion were assigned. Histopathological prostatectomy results were standard reference. RESULTS: Histopathology and cTMRI showed a spearman rho correlation of 0.658 (p?scoring showed an AUC of 0.65-0.86 on ROC-curve for both readers, with sensitivity and specificity of 81 % and 78 % at best cutoff level (reader A), respectively. When tumour characteristics were influenced by personal opinion, the sensitivity and specificity for prediction of ECE changed to 61 %-74 % and 77 %-88 % for the readers, respectively. CONCLUSIONS: Multiparametric MRI with ECE risk-scoring is an accurate diagnostic technique in determining prostate cancer clinical tumour stage and ECE at final pathology. KEY POINTS: • Multiparametric MRI is an accurate diagnostic technique for preoperative prostate cancer staging • ECE risk scoring predicts extracapsular tumour extension at final pathology • ECE risk scoring shows an AUC of 0.86 on the ROC-curve • ECE risk scoring shows a moderate inter-reader agreement (K?=?0.45) • Multiparametric MRI provides essential knowledge for optimal clinical management.

  19. Correlation between Progetto Cuore risk score and early cardiovascular damage in never treated subjects

    Directory of Open Access Journals (Sweden)

    Bertolini Stefano

    2008-09-01

    Full Text Available Abstract Background Global cardiovascular risk is a new approach which allows the physicians to quantitate the prognosis of the patients. It is therefore possible that a score, based on the major cardiovascular risk factors, is correlated with some degree of cardiovascular anatomic damage. Since this hypothesis has been demonstrated with the Framingham risk score, we decided to verify it using another score (Progetto Cuore risk score, which is probably more precise in a european low-risk population, such as the italian one. Methods We studied 84 italian caucasian subjects (50 males and 34 females with elevated blood pressure and/or dyslipidemia plus other possible cardiovascular risk factors. The subjects have never been treated for these reasons. The following evaluations were performed: history, clinical and laboratory determinations, echocardiogram, carotid echodoppler. Results The recruited people were on the whole characterized by a low cardiovascular risk, as confirmed by the low scores of the Progetto Cuore. Simple linear regression analysis showed significant associations between some parameters of early cardiovascular damage (left ventricular mass, intima-media thickness, and an integrated measure of both the carotid wall thickness and the presence of a plaque, called Carotid score and some predictors. The highest significance was found between the cardiovascular structural results and the Progetto Cuore score. In a multivariate regression analysis our model, which included factors potentially linked to the cardiovascular anatomic changes, demonstrated that the Carotid score was significantly associated with age, sex and pulse pressure; intima-media thickness with the same factors and, in addition, with the body mass index; left ventricular mass with sex, pulse pressure and body mass index. Conclusion Our paper confirms previous studies about the association between a comprehensive risk score and signs of early cardiovascular damage. A temporally limited exposure to cardiovascular risk factors, in particular to blood pressure, is already able to induce significant changes in both the heart structure and the vascular wall. Also in a european low-risk population the use of a cardiovascular risk score program, such as the Progetto Cuore in Italy, allows a quite precise estimation of the possible cardiovascular damage.

  20. Correlation between Body Condition Score, Blood Biochemical Metabolites, Milk Yield and Quality in Algerian Montbéliarde Cattle

    OpenAIRE

    Charef-Eddine Mouffok1,2,*, Toufik Madani1,2, Lounis Semara1, Nadhira Ayache1 and Amina Rahal1

    2013-01-01

    This study aimed to investigate the correlation between body condition score (BCS), blood biochemical metabolites, milk yield (MY) and quality (Mfat) in Montbéliarde cattle (31 cows) reared in 5 farms of Algerian semi arid area. The BCS was measured in dry and peak of lactation (6 weeks after calving). Blood samples were taken at the time of body condition (BC) measurement for determination of energy (Glucose, cholesterol, triglycerides and B-Hydroxybutyrate), nitrogen (urea and albumin) and ...

  1. Correlation between clinical and MRI disease activity scores in axial spondyloarthritis.

    Science.gov (United States)

    MacKay, James W; Aboelmagd, Sharief; Gaffney, J Karl

    2015-09-01

    Magnetic resonance (MR) imaging-based disease activity scores (DAS) in axial spondyloarthritis (axSpA) are rarely employed in the normal clinical setting, whereas clinical DAS are used routinely to monitor disease activity and set thresholds for biologic treatment. The objectives of this study were to evaluate the correlation between MR and clinical DAS in a general axSpA outpatient population and to assess the difference in MR DAS in individuals with high and low clinical DAS. This was a prospective, cross-sectional observational study. Forty participants with axSpA who presented for MR of the whole spine and sacroiliac joints as part of ongoing management were included. Completion of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS) was performed at the time of MR examination. MR images were scored by two independent observers using the Spondyloarthritis Research Consortium of Canada (SPARCC) MR DAS. There were weak, non-significant correlations between total SPARCC score and BASDAI (r?=?0.18, p?=?0.26), ASDAS using erythrocyte sedimentation rate (ASDAS-ESR) (r?=?0.31, p?=?0.07) and ASDAS using C-reactive protein level (ASDAS-CRP) (r?=?0.31, p?=?0.05). There was no significant difference in the SPARCC score of participants with high and low clinical DAS. MR DAS may provide information about disease activity not provided by the current standard of clinical DAS and may be considered as a useful adjunct in clinical practice. PMID:25894437

  2. Correlation of the score for subjective pain with physical disability, clinical and radiographic scores in recent onset rheumatoid arthritis

    OpenAIRE

    Turiel Maurizio; Panni Benedetta; Fiorini Tania; Sarzi-Puttini Piercarlo; Cazzola Marco; Atzeni Fabiola

    2002-01-01

    Abstract Background To analyse the relationship between subjective pain score and other measures of clinical, radiographic and functional status; in particular Larsen radiographic scores and Health Assessment Questionnaire (HAQ); in patients with severe rheumatoid arthritis (RA) with a disease duration of less than 3 years. Methods In this cross sectional study of 105 patients with RA (76 women, 29 men: mean age 50.93; mean disease duration 15.86 months; 71% rheumatoid factor positive) subjec...

  3. Correlated physical and mental health summary scores for the SF-36 and SF-12 Health Survey, V.1

    OpenAIRE

    Cunningham William E; Farivar Sepideh S; Hays Ron D

    2007-01-01

    Abstract Background The SF-36 and SF-12 summary scores were derived using an uncorrelated (orthogonal) factor solution. We estimate SF-36 and SF-12 summary scores using a correlated (oblique) physical and mental health factor model. Methods We administered the SF-36 to 7,093 patients who received medical care from an independent association of 48 physician groups in the western United States. Correlated physical health (PCSc) and mental health (MCSc) scores were constructed by multiplying eac...

  4. Prostate cancer staging with extracapsular extension risk scoring using multiparametric MRI: a correlation with histopathology

    Energy Technology Data Exchange (ETDEWEB)

    Boesen, Lars; Mikines, Kari [Herlev University Hospital, Department of Urology, Herlev (Denmark); Chabanova, Elizaveta; Loegager, Vibeke; Thomsen, Henrik S. [Herlev University Hospital, Department of Radiology, Herlev (Denmark); Balslev, Ingegerd [Herlev University Hospital, Department of Pathology, Herlev (Denmark)

    2015-06-01

    To evaluate the diagnostic performance of preoperative multiparametric MRI with extracapsular extension (ECE) risk-scoring in the assessment of prostate cancer tumour stage (T-stage) and prediction of ECE at final pathology. Eighty-seven patients with clinically localised prostate cancer scheduled for radical prostatectomy were prospectively enrolled. Multiparametric MRI was performed prior to prostatectomy, and evaluated according to the ESUR MR prostate guidelines by two different readers. An MRI clinical T-stage (cT{sub MRI}), an ECE risk score, and suspicion of ECE based on tumour characteristics and personal opinion were assigned. Histopathological prostatectomy results were standard reference. Histopathology and cT{sub MRI} showed a spearman rho correlation of 0.658 (p < 0.001) and a weighted kappa = 0.585 [CI 0.44;0.73](reader A). ECE was present in 31/87 (36 %) patients. ECE risk-scoring showed an AUC of 0.65-0.86 on ROC-curve for both readers, with sensitivity and specificity of 81 % and 78 % at best cutoff level (reader A), respectively. When tumour characteristics were influenced by personal opinion, the sensitivity and specificity for prediction of ECE changed to 61 %-74 % and 77 %-88 % for the readers, respectively. Multiparametric MRI with ECE risk-scoring is an accurate diagnostic technique in determining prostate cancer clinical tumour stage and ECE at final pathology. (orig.)

  5. Prostate cancer staging with extracapsular extension risk scoring using multiparametric MRI: a correlation with histopathology

    International Nuclear Information System (INIS)

    To evaluate the diagnostic performance of preoperative multiparametric MRI with extracapsular extension (ECE) risk-scoring in the assessment of prostate cancer tumour stage (T-stage) and prediction of ECE at final pathology. Eighty-seven patients with clinically localised prostate cancer scheduled for radical prostatectomy were prospectively enrolled. Multiparametric MRI was performed prior to prostatectomy, and evaluated according to the ESUR MR prostate guidelines by two different readers. An MRI clinical T-stage (cTMRI), an ECE risk score, and suspicion of ECE based on tumour characteristics and personal opinion were assigned. Histopathological prostatectomy results were standard reference. Histopathology and cTMRI showed a spearman rho correlation of 0.658 (p < 0.001) and a weighted kappa = 0.585 [CI 0.44;0.73](reader A). ECE was present in 31/87 (36 %) patients. ECE risk-scoring showed an AUC of 0.65-0.86 on ROC-curve for both readers, with sensitivity and specificity of 81 % and 78 % at best cutoff level (reader A), respectively. When tumour characteristics were influenced by personal opinion, the sensitivity and specificity for prediction of ECE changed to 61 %-74 % and 77 %-88 % for the readers, respectively. Multiparametric MRI with ECE risk-scoring is an accurate diagnostic technique in determining prostate cancer clinical tumour stage and ECE at final pathology. (orig.)

  6. Using IQ Discrepancy Scores To Examine the Neural Correlates of Specific Cognitive Abilities

    Science.gov (United States)

    Margolis, Amy; Bansal, Ravi; Hao, Xuejun; Algermissen, Molly; Erickson, Cole; Klahr, Kristin W.; Naglieri, Jack A.

    2013-01-01

    The underlying neural determinants of general intelligence have been studied intensively, and seem to derive from the anatomical and functional characteristics of a frontoparietal network. Little is known, however, about the underlying neural correlates of domain-specific cognitive abilities, the other factors hypothesized to explain individual performance on intelligence tests. Previous preliminary studies have suggested that spatially distinct neural structures do not support domain-specific cognitive abilities. To test whether differences between abilities that affect performance on verbal and performance tasks derive instead from the morphological features of a single anatomical network, we assessed in two independent samples of healthy human participants (N = 83 and N = 58; age range, 5–57 years) the correlation of cortical thickness with the magnitude of the verbal intelligence quotient (VIQ)-performance intelligence quotient (PIQ) discrepancy. We operationalized the VIQ-PIQ discrepancy by regressing VIQ onto PIQ (VIQ-regressed-on-PIQ score), and by regressing PIQ onto VIQ (PIQ-regressed-on-VIQ score). In both samples, a progressively thinner cortical mantle in anterior and posterior regions bilaterally was associated with progressively greater (more positive) VIQ-regressed-on-PIQ scores. A progressively thicker cortical mantle in anterior and posterior regions bilaterally was associated with progressively greater (more positive) PIQ-regressed-on-VIQ scores. Variation in cortical thickness in these regions accounted for a large portion of the overall variance in magnitude of the VIQ-PIQ discrepancy. The degree of hemispheric asymmetry in cortical thickness accounted for a much smaller but statistically significant portion of variance in VIQ-PIQ discrepancy. PMID:23986248

  7. Correlation between Apgar score and urinary uric acid to creatinine ratio in perinatal asphyxia

    OpenAIRE

    Basu, Pallab; Som, Sabyasachi; Choudhuri, Nabendu; Das, Harendranath

    2008-01-01

    A randomized case control hospital based study was conducted over 12 months time on 31 asphyxiated and 31 normal newborn to see whether urinary uric acid can be used as a marker of perinatal asphyxia and can be correlated with the clinical diagnosis by Apgar score. Uric acid and creatinine were estimated in spot urine within 24 hours after birth in both cases and controls. A ratio between concentrations of uric acid to creatinine was estimated and compared between cases and controls. It was f...

  8. Evaluation of cytogenetic damage in workers exposed to microwave radiation of GEM radar using new criteria in scoring micronucleus test

    International Nuclear Information System (INIS)

    The cytokinesis-block micronucleus assay is one of the standard cytogenetic tools employed in the assessment of chromosomal damage subsequent to the exposure to genotoxic/cytotoxic agents on human cells. Within the frame of this study, the cytokinesis-block micronucleus assay was used to assess the baseline cytogenetic damage in binuclear lymphocytes in workers occupationally exposed to microwave radiation of GEM radar by virtue of measuring the frequency of micronuclei, nucleoplasmic bridges and nuclear buds. Microwave radiation of GEM radar equipment acts within microwave field of 10 ?W/cm2 to 10 mW/cm2 and frequency range of 1.5 GHz to 10.9 GHz that has contradictory cytogenetic effect on human cells and DNA molecule. For that reason we used new criteria in scoring micronucleus assay that allows us to measure nucleoplasmic bridges and nuclear buds in addition to micronucleus frequency for more accurate effect on possible damage on the level of the cells. Parameters of the micronucleus test were studied in workers occupationally exposed to microwave radiation of GEM radar and in corresponding unexposed control subjects. It was found that in the subjects who were occupationally exposed to microwave radiation, the levels of micronuclei increased and showed interindividual variations. In addition, new parameters that were measured; nucleoplasmic bridges and nuclear buds, were detected in exposed group in compare to control group that did not shown this type of damage. Differences between mean group values were statistically significant (P<0.05). Our study indicates that micronucleus assay is a very useful tool in the assessment of cytogenetic damage of individuals exposed to microwave radiation of GEM radar equipment. On the basis of the micronucleus frequency and frequencies of nucleoplasmic bridges and nuclear buds, the micronucleus technique with an easy and short-term application and with an easy scoring can be used for detection of damage induced by this type of radiation. (author)

  9. GENETIC CORRELATION ESTIMATES AMONG BODY CONDITION SCORE, DAIRY FORM, DAYS OPEN AND PRODUCTION TRAITS FOR US HOLSTEINS

    Science.gov (United States)

    The objectives of this study were to estimate genetic correlations among body condition score (BCS), dairy form (DF), days open (DO), ME milk, ME fat and ME protein production. Body condition score and DF obtained from the Holstein Association USA Inc. were merged with DO and production data from th...

  10. Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores

    OpenAIRE

    Yoshikazu Kobayashi; Masaaki Habara; Hidekazu Ikezazki; Ronggang Chen; Yoshinobu Naito; Kiyoshi Toko

    2010-01-01

    Effective R&D and strict quality control of a broad range of foods, beverages, and pharmaceutical products require objective taste evaluation. Advanced taste sensors using artificial-lipid membranes have been developed based on concepts of global selectivity and high correlation with human sensory score. These sensors respond similarly to similar basic tastes, which they quantify with high correlations to sensory score. Using these unique properties, these sensors can quantify the basic t...

  11. Correlacao do EuroSCORE com o surgimento de lesao renal aguda pos-operatoria em cirurgia cardiaca / Correlation of the EuroSCORE with the onset of postoperative acute kidney injury in cardiac surgery

    Scientific Electronic Library Online (English)

    Edmilson Bastos de, Moura; Saint-Clair Gomes, Bernardes Neto; Fabio Ferreira, Amorim; Renato Camargo, Viscardi.

    2013-09-01

    Full Text Available OBJETIVO: Verificar se há correlação entre valores do EuroSCORE e o risco de desenvolver lesão renal aguda em pacientes submetidos à cirurgia cardíaca. MÉTODOS: Estudo retrospectivo, realizado em hospital terciário, em pacientes consecutivos com indicação para abordagem cirúrgica cardíaca (val [...] vares, isquêmicas e congênitas) entre outubro de 2010 a julho de 2011. RESULTADOS: Foram avaliados cem pacientes. Destes, seis foram excluídos (cinco por doença renal ou terapia dialítica prévias e um devido a informações incompletas no prontuário médico). As principais indicações cirúrgicas foram revascularização miocárdica em 55 pacientes (58,5% dos casos) e trocas valvares em 28 pacientes (29,8%). Conforme o EuroSCORE, 55 pacientes foram classificados como risco alto (58,5%), 27 pacientes como risco médio (28,7%) e 12 pacientes como risco baixo (12,8%). No período pós-operatório, 31 pacientes (33%) evoluíram com aumento da creatinina sérica (18 (19,1%) RIFLE "R"; 7 (7,4%) RIFLE "I"; e 6 (6,5%) RIFLE "F"). Na amostra considerada de alto risco pelos critérios do EuroSCORE, 24 pacientes (43,6%) apresentaram comprometimento renal agudo. Nos pacientes classificados como de médio e de baixo risco, ocorreu lesão renal aguda em 18,5 e 16,6% dos casos, respectivamente. A associação entre a estratificação de risco (baixo, médio e alto) do EuroSCORE e o escore do RIFLE pós-operatório foi estatisticamente significante (p=0,03). CONCLUSÃO: Na população estudada, houve correlação estatisticamente significante entre o EuroSCORE e o risco de desenvolvimento de lesão renal aguda no pós-operatório de cirurgia cardíaca. Abstract in english OBJECTIVE: The objective of this study was to assess the correlation between the European System for Cardiac Operative Risk Evaluation (EuroSCORE) score and the risk of developing acute kidney injury in cardiac surgery patients. METHODS: This retrospective study was conducted at a tertiary hos [...] pital on consecutive cardiac surgery patients (e.g., valvular, ischemic and congenital heart diseases) between October 2010 and July 2011. RESULTS: One hundred patients were assessed. Among the 100 patients, six were excluded, including five because of prior kidney disease or dialysis therapy and one because of incomplete medical records. The primary surgical indications were myocardial revascularization in 55 patients (58.5% of cases) and valve replacement in 28 patients (29.8%). According to the EuroSCORE, 55 patients were classified as high risk (58.5%), 27 patients as medium risk (28.7%) and 12 patients as low risk (12.8%). In the postoperative period, patients were classified with the Risk, Injury, Failure, Loss and End-stage kidney disease (RIFLE) score. Among the 31 patients (33%) who displayed an increase in serum creatinine, 18 patients (19.1%) were classified as RIFLE "R" (risk), seven patients (7.4%) were classified as RIFLE "I" (injury) and six patients (6.5%) were classified as RIFLE "F" (failure). Among the patients who were considered to be high risk according to the EuroSCORE criteria, 24 patients (43.6%) showed acute kidney injury. Among the patients who were classified as medium or low risk, acute kidney injury occurred in 18.5 and 16.6% of the cases, respectively. The correlations between risk stratification (low, medium and high) and the EuroSCORE and postoperative RIFLE scores were statistically significant (p=0.03). CONCLUSION: In the studied population, there was a statistically significant correlation between the EuroSCORE and the risk of developing acute kidney injury in the postoperative period after cardiac surgery.

  12. Augmenting Species Diversity in Water Quality Criteria Derivation using Interspecies Correlation Models

    Science.gov (United States)

    The specific requirements for taxa diversity of the 1985 guidelines have limited the number of ambient water quality criteria (AWQC) developed for aquatic life protection. The EPA developed the Web-based Interspecies Correlation Estimation (Web-ICE) tool to allow extrapolation of...

  13. Prognostic Factors for Open Globe Injuries and Correlation of Ocular Trauma Score in Tianjin, China

    Science.gov (United States)

    Meng, Yu; Yan, Hua

    2015-01-01

    Purpose. To investigate prognostic factors that influence the final visual acuity (VA) and to correlate the ocular trauma score (OTS) with the final VA in open globe injuries. Methods. A retrospective review of 298 patients with open globe injuries admitted to Tianjin Medical University General Hospital was carried out from January 1, 2010, till December 31, 2014. Prognostic factors influencing the final VA in patients with open globe injuries and the correlation between OTS and the final VA were examined. Results. Three hundred and fourteen eyes from 298 patients with open globe injuries were analyzed. Males had a higher rate of open globe injury than females (83.56% versus 16.44%). Mean age was 45.46 ± 17.48 years (5–95 years). In a univariate analysis, prognostic factors influencing the final VA included initial VA, relative afferent papillary defect (RAPD), vitreous hemorrhage, lens injury, endophthalmitis, hyphema, retinal detachment, and the zone of injury. In a multiple logistic regression analysis, initial VA, RAPD, and the zone of injury were considered to be independent risk factors. The OTS correlated with final VA (r = 0.988, p = 0.000). Conclusion. In our study, the most important prognostic factors influencing the final VA were initial VA, RAPD, and the zone of injury. The OTS was of great importance for patients and ophthalmologists. PMID:26491549

  14. Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study

    DEFF Research Database (Denmark)

    van Straaten, EC; Fazekas, F; Rostrup, Egill; Scheltens, P; Schmidt, R; Pantoni, L; Inzitari, D; Waldemar, Gunhild; Erkinjuntti, T; Mantyla, R; Wahlund, LO; Barkhof, F; Group, LADIS

    2006-01-01

    to WMH load measured qualitatively using 3 widely used visual rating scales (Fazekas, Scheltens, and Age-Related White Matter Changes scales) and quantitatively with a semiautomated volumetric technique and an automatic lesion count. Statistical significance between groups was assessed with the chi2...... assessment detected differences in WMH between groups with respect to gait disturbances and age. WMH volume measurement was more sensitive than visual scores with respect to memory symptoms. Number of lesions nor lesion type correlated with any of the clinical data. For all rating scales, a clear but...... nonlinear relationship was established with WMH volume. CONCLUSIONS: Visual rating scales display ceiling effects and poor discrimination of absolute lesion volumes. Consequently, they may be less sensitive in differentiating clinical groups...

  15. Big Macs and Eigenfactor Scores: Don't Let Correlation Coefficients Fool You

    CERN Document Server

    West, Jevin; Bergstrom, Carl

    2009-01-01

    The Eigenfactor Metrics provide an alternative way of evaluating scholarly journals based on an iterative ranking procedure analogous to Google's PageRank algorithm. These metrics have recently been adopted by Thomson-Reuters and are listed alongside the Impact Factor in the Journal Citation Reports. But do these metrics differ sufficiently so as to be a useful addition to the bibliometric toolbox? Davis (2008) has argued otherwise, based on his finding of a 0.95 correlation coefficient between Eigenfactor score and total citations for a sample of journals in the field of medicine. This conclusion is mistaken; here we illustrate the basic statistical fallacy to which Davis succumbed. We provide a complete analysis of the 2006 Journal Citation Reports and demonstrate that there are important differences between the information provided by the Eigenfactor Metrics and that provided by Impact Factor and Total Citations.

  16. Rheumatoid arthritis bone erosion volumes on CT and MRI: reliability and correlations with erosion scores on CT, MRI and radiography

    DEFF Research Database (Denmark)

    Møller Døhn, Uffe; Ejbjerg, Bo J; Hasselquist, Maria; Narvestad, Eva; Court-Payen, Michel; Szkudlarek, Marcin; Møller, Jakob; Thomsen, Henrik S; Østergaard, Mikkel

    2007-01-01

    OBJECTIVES: To investigate intramodality and intermodality agreements of CT and MRI erosion volumes in metacarpophalangeal (MCP) joints in rheumatoid arthritis (RA), and to compare the volumes with erosion scores for CT, MRI and radiography. METHODS: In total, 17 patients with RA and four healthy...... controls underwent unilateral CT, MRI and radiography of second to fifth MCP joints in one hand. Erosion volumes (using OSIRIS software) and scores were determined from CT, MRI and radiography (scores only). RESULTS: CT, MRI and radiography detected 77, 62 and 12 erosions, respectively. On CT, the mean...... MRI) and 0.64 to 0.89 (CT vs MRI), all p<0.01. MRI erosion volumes correlated with the Outcome Measures in Rheumatology Clinical Trials/Rheumatoid Arthritis Magnetic Resonance Imaging Score (OMERACT RAMRIS) erosion scores (0.91 to 0.99; p<0.01) and the Sharp/van der Heijde erosion score (0.49 to 0...

  17. Secondhand smoke exposure and other correlates of susceptibility to smoking: a propensity score matching approach.

    Science.gov (United States)

    McIntire, Russell K; Nelson, Ashlyn A; Macy, Jonathan T; Seo, Dong-Chul; Kolbe, Lloyd J

    2015-09-01

    Secondhand smoke (SHS) exposure is responsible for numerous diseases of the lungs and other bodily systems among children. In addition to the adverse health effects of SHS exposure, studies show that children exposed to SHS are more likely to smoke in adolescence. Susceptibility to smoking is a measure used to identify adolescent never-smokers who are at risk for smoking. Limited research has been conducted on the influence of SHS on susceptibility to smoking. The purpose of this study was to determine a robust measure of the strength of correlation between SHS exposure and susceptibility to smoking among never-smoking U.S. adolescents. This study used data from the 2009 National Youth Tobacco Survey to identify predictors of susceptibility to smoking in the full (pre-match) sample of adolescents and a smaller (post-match) sample created by propensity score matching. Results showed a significant association between SHS exposure and susceptibility to smoking among never-smoking adolescents in the pre-match (OR=1.47) and post-match (OR=1.52) samples. The odds ratio increase after matching suggests that the strength of the relationship was underestimated in the pre-match sample. Other significant correlates of susceptibility to smoking identified include: gender, race/ethnicity, personal income, smoke-free home rules, number of smoking friends, perception of SHS harm, perceived benefits of smoking, and exposure to pro-tobacco media messages. The use of propensity score matching procedures reduced bias in the post-match sample, and provided a more robust estimate of the influence of SHS exposure on susceptibility to smoking, compared to the pre-match sample estimates. PMID:25967679

  18. Correlación entre score de calcio coronario, esteatosis hepática y síndrome metabólico / Correlation between coronary calcium score, hepatic steatosis and metabolic syndrome

    Scientific Electronic Library Online (English)

    Karina, Hermosilla M; Daniela, Pivcevic C; Julia, Alegria B; Claudio, Silva F.

    Full Text Available Objetivos. Demostrar la correlación que existe entre presencia o no de enfermedad coronaria establecida (medida a través del índice de Agatston) y esteatosis hepática en los segmentos visualizados del hígado al momento de realizar el score de calcio. Material y Métodos. Estudio retrospectivo que inc [...] luyó 229 pacientes con factores de riesgo para enfermedad coronaria a los que se les realizó tomografía computada multicorte de arterias coronarias o score de calcio. Se evaluó la presencia de enfermedad ateromatosa en arterias coronarias y aorta torácica y atenuación hepática en los segmentos visualizados del hígado. El análisis estadístico incluyó modelos de regresión lineal, estudio por asociación de múltiples variables y modelo CART. Resultados. 229 pacientes, 78% de sexo masculino y 22% femenino, con edad promedio 56 años. Se demostró asociación estadísticamente significativa entre mayor nivel de score de calcio y menor atenuación hepática, en pacientes de mayor edad y sexo masculino. Se logró definir dos tipos de pacientes con score de calcio elevado, un grupo con hipertensión arterial - esteatosis hepática y otro grupo con hipertensión arterial y diabetes tipo 2; los pacientes solamente obesos no tenían mayores niveles de score de calcio. Conclusiones. Existe asociación entre ateromatosis calcificada y esteatosis hepática. Los pacientes con esteatosis hepática como parte de un síndrome metabólico, tienen mayor riesgo de ateroesclerosis. Puede ser útil incorporar la evaluación de esteatosis hepática en la estratificación de riesgo cardiovascular. Abstract in english Objectives. To demonstrate the correlation between the presence or absence of established coronary disease (as measured by the Agatston index) and hepatic steatosis visualized in liver segments when calculating calcium score. Material and Methods. Retrospective study that included229 patients with r [...] isk factors for coronary disease who underwent multislice computed tomography of coronary arteries or calcium score. We evaluated the presence of atherosclerotic disease in coronary arteries and thoracic aorta and liver attenuation in visualized liver segments. Statistical analysis included linear regression models, association studies of multiple variables and CARTmodel. Results. 229 patients, 78% male, average age 56 years. It values statistically significant association was found between higher levels of calcium score and lower hepatic attenuation in older patients and males. We were to define two types of patients with high calcium score, a group with hypertension - hepatic steatosis and another groups with hypertension and type 2 diabetes; patients that were only obese did not have higher levels of calcium score. Conclusions. A relationship exists between calcified atheromatosis disease and hepatics steatosis. Patients with hepatics steatosis as part of a metabolic syndrome are at increased risk of atherosclerosis. It may be useful to incorporate the assessment of hepatics steatosis in cardiovascular risk stratification.

  19. Correlation between Body Condition Score, Blood Biochemical Metabolites, Milk Yield and Quality in Algerian Montbéliarde Cattle

    Directory of Open Access Journals (Sweden)

    Charef-Eddine Mouffok1,2,*, Toufik Madani1,2, Lounis Semara1, Nadhira Ayache1 and Amina Rahal1

    2013-04-01

    Full Text Available This study aimed to investigate the correlation between body condition score (BCS, blood biochemical metabolites, milk yield (MY and quality (Mfat in Montbéliarde cattle (31 cows reared in 5 farms of Algerian semi arid area. The BCS was measured in dry and peak of lactation (6 weeks after calving. Blood samples were taken at the time of body condition (BC measurement for determination of energy (Glucose, cholesterol, triglycerides and B-Hydroxybutyrate, nitrogen (urea and albumin and mineral (calcium metabolites. Milk yield was recorded in the 6th week of lactation (peak. A sample of milk for each cow was used to determinate milk fat, density and acidity. The results showed a significant decrease in postpartum BCS accompanied by an increase in cholesterol and B-Hydroxybutyrate (BHB concentration. The correlation analysis showed that BHB concentration in pre calving was negatively correlated with BCS (r=-0.321; P<0.05 and cholesterol (r=-0.308; P<0.05. In postpartum, BCS was negatively correlated with cholesterol (r=-0.416; P<0.05, urea (r=-0.366; P<0.05 and BHB (r=-0.487; P<0.05. However, the level of milk production decreased significantly with high glucose (r=-0.449; P<0.05 and BHB (r=-0.514; P<0.05. The fat content increased significantly with blood triglycerides (r=0.681; P<0.05 and BHB (r=0.522; P<0.05 concentration, indicating a high mobilization of body reserves used for the synthesis of milk fat. In conclusion, it can be assumed that the rate of BHB seems to be the best indicator of the nutritional status of dairy cows that determines their production level and quality.

  20. Modified Chrispin-Norman chest radiography score for cystic fibrosis: observer agreement and correlation with lung function

    International Nuclear Information System (INIS)

    To test observer agreement and two strategies for possible improvement (consensus meeting and reference images) for the modified Chrispin-Norman score for children with cystic fibrosis (CF). Before and after a consensus meeting and after developing reference images three observers scored sets of 25 chest radiographs from children with CF. Observer agreement was tested for line, ring, mottled and large soft shadows, for overinflation and for the composite modified Chrispin-Norman score. Correlation with lung function was assessed. Before the consensus meeting agreement between observers 1 and 2 was moderate-good, but with observer 3 agreement was poor-fair. Scores correlated significantly with spirometry for observers 1 and 2 (-0.72< R<-0.42, P < 0.05), but not for observer 3. Agreement with observer 3 improved after the consensus meeting. Reference images improved agreement for overinflation and mottled and large shadows and correlation with lung function, but agreement for the modified Chrispin-Norman score did not improve further. Consensus meetings and reference images improve among-observer agreement for the modified Chrispin-Norman score, but good agreement was not achieved among all observers for the modified Chrispin-Norman score and for bronchial line and ring shadows. (orig.)

  1. Modified Chrispin-Norman chest radiography score for cystic fibrosis: observer agreement and correlation with lung function

    Energy Technology Data Exchange (ETDEWEB)

    Jong, P.A. de; Achterberg, J.A.; Kessels, O.A.M.; Beek, F.J. [Department of Radiology, University Medical Center Utrecht, Wilhelmina Children' s Hospital, Utrecht (Netherlands); Ginneken, B. van; Hogeweg, L. [Radboud University Nijmegen Medical Centre, Department of Radiology, Nijmegen (Netherlands); Image Sciences Institute, University Medical Center Utrecht, Utrecht (Netherlands); Terheggen-Lagro, S.W.J. [University Medical Center Utrecht, Wilhelmina Children' s Hospital, Department of Pediatric Pulmonology, Utrecht (Netherlands)

    2011-04-15

    To test observer agreement and two strategies for possible improvement (consensus meeting and reference images) for the modified Chrispin-Norman score for children with cystic fibrosis (CF). Before and after a consensus meeting and after developing reference images three observers scored sets of 25 chest radiographs from children with CF. Observer agreement was tested for line, ring, mottled and large soft shadows, for overinflation and for the composite modified Chrispin-Norman score. Correlation with lung function was assessed. Before the consensus meeting agreement between observers 1 and 2 was moderate-good, but with observer 3 agreement was poor-fair. Scores correlated significantly with spirometry for observers 1 and 2 (-0.72correlation with lung function, but agreement for the modified Chrispin-Norman score did not improve further. Consensus meetings and reference images improve among-observer agreement for the modified Chrispin-Norman score, but good agreement was not achieved among all observers for the modified Chrispin-Norman score and for bronchial line and ring shadows. (orig.)

  2. Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study

    DEFF Research Database (Denmark)

    van Straaten, EC; Fazekas, F

    2006-01-01

    BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) are associated with decline in cognition, gait, mood, and urinary continence. Associations may depend on the method used for measuring WMH. We investigated the ability of different WMH scoring methods to detect differences in WMH load between groups with and without symptoms. METHODS: We used data of 618 independently living elderly with WMH collected in the Leukoaraiosis And DISability (LADIS) study. Subjects with and without symptoms of depression, gait disturbances, urinary incontinence, and memory decline were compared with respect to WMH load measured qualitatively using 3 widely used visual rating scales (Fazekas, Scheltens, and Age-Related White Matter Changes scales) and quantitatively with a semiautomated volumetric technique and an automatic lesion count. Statistical significance between groups was assessed with the chi2 and Mann-Whitney tests. In addition, the punctate and confluent lesion type with comparable WMH volume were compared withrespect to the clinical data using Student t test and chi2 test. Direct comparison of visual ratings with volumetry was done using curve fitting. RESULTS: Visual and volumetric assessment detected differences in WMH between groups with respect to gait disturbances and age. WMH volume measurement was more sensitive than visual scores with respect to memory symptoms. Number of lesions nor lesion type correlated with any of the clinical data. For all rating scales, a clear but nonlinear relationship was established with WMH volume. CONCLUSIONS: Visual rating scales display ceiling effects and poor discrimination of absolute lesion volumes. Consequently, they may be less sensitive in differentiating clinical groups

  3. Three-dimensional contrast enhanced ultrasound score and dynamic contrast-enhanced magnetic resonance imaging score in evaluating breast tumor angiogenesis: Correlation with biological factors

    Energy Technology Data Exchange (ETDEWEB)

    Jia, Wan-Ru, E-mail: jiawanru@126.com [Department of Diagnostic Ultrasound, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197 Rui Jin 2nd Road, Shanghai 200025 (China); Chai, Wei-Min, E-mail: chai_weimin@yahoo.com.cn [Department of Radiology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197 Rui Jin 2nd Road, Shanghai 200025 (China); Tang, Lei, E-mail: jessietang1003@163.com [Department of Diagnostic Ultrasound, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197 Rui Jin 2nd Road, Shanghai 200025 (China); Wang, Yi, E-mail: xiatian.0602@163.com [Department of Diagnostic Ultrasound, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197 Rui Jin 2nd Road, Shanghai 200025 (China); Fei, Xiao-Chun, E-mail: xcf0222@163.com [Department of Pathology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197 Rui Jin 2nd Road, Shanghai 200025 (China); Han, Bao-San, E-mail: hanbaosan@126.com [Department of Comprehensive Breast Health Center, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197 Rui Jin 2nd Road, Shanghai 200025 (China); Chen, Man, E-mail: lucyjia1370@126.com [Department of Diagnostic Ultrasound, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197 Rui Jin 2nd Road, Shanghai 200025 (China)

    2014-07-15

    Objective: To explore the clinical value of three-dimensional contrast enhanced ultrasound (3D-CEUS) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) score systems in evaluating breast tumor angiogenesis by comparing their diagnostic efficacy and correlation with biological factors. Methods: 3D-CEUS was performed in 183 patients with breast tumors by Esaote Mylab90 with SonoVue (Bracco, Italy), DCE-MRI was performed on a dedicated breast magnetic resonance imaging (DBMRI) system (Aurora Dedicated Breast MRI Systems, USA) with a dedicated breast coil. 3D-CEUS and DCE-MRI score systems were created based on tumor perfusion and vascular characteristics. Microvessel density (MVD), vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP-2, MMP-9) expression were measured by immunohistochemistry. Results: Pathological results showed 35 benign and 148 malignant breast tumors. MVD (P = 0.000, r = 0.76), VEGF (P = 0.000, r = 0.55), MMP-2 (P = 0.000, r = 0.39) and MMP-9 (P = 0.000, r = 0.41) expression were all significantly different between benignity and malignancy. Regarding 3D-CEUS 4 points as cutoff value, the sensitivity, specificity and accuracy were 85.1%, 94.3% and 86.9%, respectively, and correlated well with MVD (P = 0.000, r = 0.50), VEGF (P = 0.000, r = 0.50), MMP-2 (P = 0.000, r = 0.50) and MMP-9 (P = 0.000, r = 0.66). Taking DCE-MRI 5 points as cutoff value, the sensitivity, specificity and accuracy were 86.5%, 94.3% and 88.0%, respectively and also correlated well with MVD (P = 0.000, r = 0.52), VEGF (P = 0.000, r = 0.44), MMP-2 (P = 0.000, r = 0.42) and MMP-9 (P = 0.000, r = 0.35). Conclusions: 3D-CEUS score system displays inspiring diagnostic performance and good agreement with DCE-MRI scoring. Moreover, both score systems correlate well with MVD, VEGF, MMP-2 and MMP-9 expression, and thus have great potentials in tumor angiogenesis evaluation.

  4. A STUDY OF PREDICTION OF DIFFICULT INTUBATION USING MALLAMPATI AND WILSON SCORE CORRELATING WITH CORMACK LEHANE GRADING

    Directory of Open Access Journals (Sweden)

    Vaishali Chandrashekhar

    2015-06-01

    Full Text Available BACKGROUND : This study was carried out to evaluate usefulness of preoperative Mallampati & Wilson’s score grading as a predictor for difficult laryngoscopy & intubation . AIMS : To determine the accuracy of the modified Mallampati test and Wilson score for predicting difficult tracheal intubation and correlation with Cormack Lehane grading . METHODS : This prospective randomized cross sectional Study carried out in 200 patients , posted for surgical procedure under GA with ETT intubation. Preoperative airway assessment using Mallampati grading (MPG & Wilson score done. Conventional anesthesia t echnique followed. Cormack Lehane grading done at laryngoscopy & correlated with previous scores for each patient. RESULTS : A MPG of I/II was found in 140 patients (70% , while 60 patients (30% were class III/IV. 138 patients (69% had a Wilson score of 0 /1 , while 60(30% had a score of 2/3 and 2 patients (1% scored ?4. One hundred & eighty patients (90% were classified as Cormack - Lehane grade I/II , while 20 patients (10% were considered grade III/IV. Of the 60 patients with a Wilson score of 2/3 , 6 cas es (10% two attempts were required and in 2 cases (3.3% in spite of more than two attempts intubation proved impossible with the conventional laryngoscope , articulated McCoy blade was used. Two patients with a Wilson score ?4 were intubated with gum elas tic bougie , using articulated McCoy blade. Overall , out of 200 , in 6 patients (3% two attempts of intubation was required and 4 patients (2% intubation required the use of some kind of gadget other than conventional laryngoscope and more than 2 attempts. The correlation between the Cormack - Lehane classification and the number of endotracheal intubation attempts showed that of the 180 patients with I / II grade , 4 patients (1.3% two attempts were required. Of the 20 patients classified as Cormack - Lehane III/IV , 4 cases (20% intubation proved impossible with conventional technique. This correlation was statistically significant. DISCUSSION : The Wilson score can successfully predict the patients in whom laryngoscopy may prove dif ficult (Wilson 2/3 (p = 0. 01. This reflects the good sensitivity. CONCLUSIONS : Wilson score , despite being seldom used in clinical practice , is a highly sensitive predictor of a difficult airway , although its specificity is low. KEYWORDS : Difficult intubation Prediction , Mallampa ti , Wilson score , Cormack Lehane grading , Specificity & Sensitivity.

  5. Body condition score and its correlation with ultrasonographic back fat thickness in transition crossbred cows

    Directory of Open Access Journals (Sweden)

    Randhir Singh

    2015-03-01

    Full Text Available Aim: The aim was to study the effect of the transition to body condition score (BCS and ultrasonographic back fat thickness (USG BFT in crossbred cows. Materials and Methods: A total of 101 multiparous crossbred cows in advanced pregnancy from organized dairy farm were taken up for study. The cows were grouped according to transition stage, i.e. far off dry (FOD, close up dry (CUD and fresh (F. BCS was estimated by using the five point visual BCS technique with 0.5 increments. The USG BFT was measured by real-time ultrasound using a portable Sonosite instrument. Results: In cows with BCS 2-2.5, the BFT of F period was significantly lower than FOD period. In cows with BCS 3-3.5, the mean BFT at F period was significantly reduced as compared to FOD and CUD period. The overall correlation coefficient between BCS and BFT for different transition stages was 84%, 79% and 75% for FOD, CUD and F period, respectively. Conclusion: The USG BFT gives an accurate measure of fat reserves in cows. The cows with BCS of ?3.5 entering the transition period are more prone to lose body condition and hence require better and robust management during the transition period.

  6. Anomalous Diffusion and Long-range Correlations in the Score Evolution of the Game of Cricket

    OpenAIRE

    Ribeiro, H. V.; Mukherjee, Satyam; Zeng, Xiao Han T.

    2012-01-01

    We investigate the time evolution of the scores of the second most popular sport in world: the game of cricket. By analyzing the scores event-by-event of more than two thousand matches, we point out that the score dynamics is an anomalous diffusive process. Our analysis reveals that the variance of the process is described by a power-law dependence with a super-diffusive exponent, that the scores are statistically self-similar following a universal Gaussian distribution, and that there are lo...

  7. Symmetric dimethylarginine (SDMA) serum levels in rheumatoid arthritis: correlations with insulin resistance and disease activity scores.

    Science.gov (United States)

    Dimitroulas, Theodoros; Hodson, James; Sandoo, Aamer; Smith, Jacqueline; Kitas, George D

    2015-09-01

    Vascular abnormalities predisposing to atherosclerosis are present in patients with rheumatoid arthritis (RA) and associate with excess cardiovascular risk. Symmetric dimethylarginine (SDMA), an endogenous inhibitor of nitric oxide (NO) synthase activity, has been recognised as novel risk factor for endothelial dysfunction and cardiovascular disease. We aimed to compare SDMA levels in RA patients and controls and to investigate whether they are influenced by demographic, inflammatory or metabolic factors. Serum SDMA levels were measured in 197 RA individuals [median age: 67 years (quartiles: 59-3), 153 (78 %) females] and 82 controls [median age: 44 years [quartiles: 33-55, 50 (61 %) females]. Routine biochemistry tests, lipid profile, glycemic profile [glucose, insulin, homeostasis model assessment (HOMA-IR), quantitative insulin sensitivity check index (QUICKI)], as well as inflammatory markers were measured in all patients. Paired analysis was employed for the comparison of SDMA in two groups and multivariable regression models were performed to identify predictors of SDMA in the RA cohort. SDMA was significantly lower in RA than control patients in both unpaired and paired analyses (P < 0.001 and P = 0.005, respectively), with the magnitude of the difference being similar in both models. QUICKI (P = 0.005) and disease activity score-28 (P = 0.007) were positively related to SDMA in the RA cohort, whilst a negative correlation with renal function (eGFR) was detected (P = 0.005). The molecular explanation of lower serum SDMA is unclear, but the established relationships with indices of disease activity and insulin resistance, may underline the pathogenetic role of the L-arginine/NO pathway dysregulation in the development of atherosclerosis in RA. The biological and clinical importance of SDMA in RA remains to be evaluated in clinical and experimental studies. PMID:25772817

  8. Correlation of JAK2V617F mutational status in primary myelofibrosis with clinico-hematologic characteristics and international prognostic scoring system scoring: A single center experience

    Directory of Open Access Journals (Sweden)

    Neha Singh

    2015-01-01

    Full Text Available Introduction: Somatic mutation in the exon 14 of Janus Kinase 2 gene is an established diagnostic marker in bcr-abl negative myeloproliferative neoplasms, especially primary idiopathic myelofibrosis (PIMF. Aim: Our primary aim was to find out the correlation between the JAK2V617F mutational status and the clinico-hematologic characteristics, as well as the international prognostic scoring system (IPSS scoring of patients with PIMF. Materials and Methods: Clinical and hematologic features were reviewed for 68 patients with primary idiopathic myelofibrosis (PIMF. JAK2V617F mutation status was analyzed by amplification refractory mutation screening-polymerase chain reaction. The patients were further stratified into low, intermediate-1, intermediate-2 and high-risk groups on the basis of IPSS scoring. Results: The JAK2V617F mutation was detected in 58.8% patients. Univariate analysis of variables at presentation identified that JAK2V617F negative patients were significantly associated with more severe anemia (P = 0.045, younger age (P = 0.008, higher transfusion requirement (P = 0.017, and thrombocytopenia (P = 0.015. Patients who were homozygous for JAK2V617F mutation were associated with thrombocytosis (P = 0.014 and also had higher median total leucocyte count (P = 0.20 than the other groups. No significant correlation was detected between JAK2V617F mutational status and the presence of constitutional symptoms, spleen size, grade of bone marrow fibrosis or prognostic risk stratification of the PIMF patients. Conclusion: The variations in the prognostic implication of PIMF patients with mutation status as stated by various publications worldwide, reinstates the need for larger prospective studies using standardized JAK2V617F quantification methods as well as estimation of other newer molecular markers to develop deeper insight into various molecular alterations involving PIMF patients in India as well as worldwide.

  9. Rheumatoid arthritis bone erosion volumes on CT and MRI: reliability and correlations with erosion scores on CT, MRI and radiography.

    DEFF Research Database (Denmark)

    MØller DØhn, Uffe; Ejbjerg, Bo J

    2007-01-01

    OBJECTIVES: To investigate intramodality and intermodality agreements of CT and MRI erosion volumes in metacarpophalangeal (MCP) joints in rheumatoid arthritis (RA), and to compare the volumes with erosion scores for CT, MRI and radiography. METHODS: In total, 17 patients with RA and four healthy controls underwent unilateral CT, MRI and radiography of second to fifth MCP joints in one hand. Erosion volumes (using OSIRIS software) and scores were determined from CT, MRI and radiography (scores only). RESULTS: CT, MRI and radiography detected 77, 62 and 12 erosions, respectively. On CT, the mean erosion volume was 26 mm(3) (median 10; range 0 to 248) and 30 mm(3) (18; 1 to 163) on MRI. Total erosion volumes (per patient/control) were 97 mm(3) (29; 0 to 485) on CT and 90 mm(3) (46; 0 to 389) on MRI. For volumes, Spearman correlation coefficients were 0.96 to 0.99 (CT vs CT), 0.95 to 0.98 (MRI vs MRI) and 0.64 to 0.89 (CT vs MRI), all p<0.01. MRI erosion volumes correlated with the Outcome Measures in Rheumatology Clinical Trials/Rheumatoid Arthritis Magnetic Resonance Imaging Score (OMERACT RAMRIS) erosion scores (0.91 to 0.99; p<0.01) and the Sharp/van der Heijde erosion score (0.49 to 0.63; p<0.01). CONCLUSION: Very high intramodality and high intermodality agreements of CT and MRI erosion volumes were found, encouraging further testing in longitudinal studies. A close correlation with CT and MRI erosion volumes supports the OMERACT RAMRIS erosion score as a valid measure of joint destruction in RA. Udgivelsesdato: 2007-Oct

  10. Improved correlation between carotid and coronary atherosclerosis SYNTAX score using automated ultrasound carotid bulb plaque IMT measurement.

    Science.gov (United States)

    Ikeda, Nobutaka; Gupta, Ajay; Dey, Nilanjan; Bose, Soumyo; Shafique, Shoaib; Arak, Tadashi; Godia, Elisa Cuadrado; Saba, Luca; Laird, John R; Nicolaides, Andrew; Suri, Jasjit S

    2015-05-01

    Described here is a detailed novel pilot study on whether the SYNTAX (Synergy between percutaneous coronary intervention with TAXUS and cardiac surgery) score, a measure of coronary artery disease complexity, could be better predicted with carotid intima-media thickness (cIMT) measures using automated IMT all along the common carotid and bulb plaque compared with manual IMT determined by sonographers. Three hundred seventy consecutive patients who underwent carotid ultrasound and coronary angiography were analyzed. SYNTAX score was determined from coronary angiograms by two experienced interventional cardiologists. Unlike most methods of cIMT measurement commonly used by sonographers, our method involves a computerized automated cIMT measurement all along the carotid artery that includes the bulb region and the region proximal to the bulb (under the class of AtheroEdge systems from AtheroPoint, Roseville, CA, USA). In this study, the correlation between automated cIMT that includes bulb plaque and SYNTAX score was found to be 0.467 (p < 0.0001), compared with 0.391 (p < 0.0001) for the correlation between the sonographer's IMT reading and SYNTAX score. The correlation between the automated cIMT and the sonographer's IMT was 0.882. When compared against the radiologist's manual tracings, automated cIMT system performance had a lumen-intima error of 0.007818 ± 0.0071 mm, media-adventitia error of 0.0179 ± 0.0125 mm and automated cIMT error of 0.0099 ± 0.00988 mm. The precision of automated cIMT against the manual radiologist's reading was 98.86%. This current automated algorithm revealed a significantly stronger correlation between cIMT and coronary SYNTAX score as compared with the sonographer's cIMT measurements with multiple cardiovascular risk factors. We benchmarked our correlation between the automated cIMT that includes bulb plaque and SYNTAX score against a previously published (Ikeda et al. 2013) AtheroEdgeLink (AtheroPoint) correlation between the automated cIMT that does not include bulb plaque and SYNTAX score and had an improvement of 44.58%. By sampling cIMT in the bulb region, the automated cIMT technique improves the degree of correlation between coronary artery disease lesion complexity and carotid atherosclerosis characteristics. PMID:25638311

  11. Correlation of MR diffusion tensor imaging parameters with ASIA motor scores in hemorrhagic and nonhemorrhagic acute spinal cord injury.

    Science.gov (United States)

    Cheran, Sendhil; Shanmuganathan, Kathirkamanathan; Zhuo, Jiachen; Mirvis, Stuart E; Aarabi, Bizhan; Alexander, Melvin T; Gullapalli, Rao P

    2011-09-01

    This study investigated correlations between American Spinal Injury Association (ASIA) clinical injury motor scores in patients with traumatic cervical cord injury and magnetic resonance (MR) diffusion tensor imaging (DTI) parameters. Conventional imaging and DTI were performed to evaluate 25 patients (age, 39.7±13.9 years; 4 women, 21 men) with blunt spinal cord injury and 11 volunteers (age, 31.5±10.7 years; 3 women, 8 men). Cord contusions were hemorrhagic (HC) in 13 and non-hemorrhagic (NHC) in 12 patients. The spinal cord was divided into three regions to account for spatial and pathological variation in DTI parameters. Comparisons of regional and injury site mean diffusivity (MD), fractional anisotropy (FA), radial diffusivity ( ?(?)), and longitudinal diffusivity ( ?(?)) were made with control subjects. ASIA motor scores were correlated with DTI using linear regression analysis. HC and NHC patients showed significant reduction (p<0.001) in MD and ?(?) in all three regions. At the injury site, significant decreases in FA and ?(?) were seen for both injury groups (p<0.001). ?(?) values were significantly increased only for patients with NHC (p<0.05). Significant reduction in FA and ?(?) (p<0.0001) was observed at the whole cord level between the injured (NH and NHC) and control groups. Within the NHC group, strong correlations were observed between ASIA motor scores and average MD, FA, ?(?), and ?(?) at the injury site. However, no correlation was observed within the HC group between any of the DTI parameters and ASIA motor scores. DTI parameters reflect the severity of spinal cord injury and correlate well with ASIA motor scores in patients with NHC. PMID:21875333

  12. A Study on the Correlation between Cord Blood Glucose Level and the Apgar Score

    OpenAIRE

    Khan, Kalyan; Saha, Ashis Ranjan

    2013-01-01

    Introduction: The study of the biochemical parameters of cord blood acts as a mirror, which usually reflects the neonatal status. The widely used system for the evaluation of a neonate is the Apgar score. There is no comprehensive published data which has established the association between the cord blood glucose level and the Apgar score. Similarly, there is also no well accepted reference range of the cord blood glucose level.

  13. Correlation of proton MR spectroscopic imaging with Galena's score based on step-section pathologic analysis after radical prostatectomy

    International Nuclear Information System (INIS)

    Purpose: To determine whether hydrogen 1 magnetic resonance (MR) spectroscopic imaging can be used to predict aggressiveness of prostate cancer. Materials and Methods: All patients gave informed consent according to an institutionally approved research protocol. A total of 123 patients (median age, 58 years; age range, 40-74 years) who underwent endorectal MR imaging and MR spectroscopic imaging between January 2000 and December 2002 were included. MR imaging and spectroscopy were performed by using combined pelvic phased-array and endorectal probe. Water and lipids were suppressed, and phase-encoded data were acquired with 6.2-mm resolution. Voxels in the peripheral zone were considered suspicious for cancer if (Cho + Cr)/Cit was at least two standard deviations above the normal level, where Cho represents choline-containing compounds, Cr represents creatine and phosphocreatine, and Cit represents citrate. Correlation between metabolite ratio and four Gleason score groups identified at step-section pathologic evaluation (3 + 3, 3 + 4, 4 + 3, and > or =4 + 4) was assessed with generalized estimating equations. Results: Data from 94 patients were included. Pathologic evaluation was used to identify 239 lesions. Overall sensitivity of MR spectroscopic imaging was 56% for tumor detection, increasing from 44% in lesions with Gleason score of 3 + 3 to 89% in lesions with Gleason score greater than or equal to 4 + 4. There was a trend toward increasing (Cho + Cr)/Cit with increasing Gleason score in lesions identified correctly with MR spectroscopic imaging. Tumor volume assessed with MR spectroscopic imaging increased with increasing Gleason score. Conclusion: MR spectroscopic imaging measurement of prostate tumor (Cho + Cr)/Cit and tumor volume correlate with pathologic Gleason score. There is overlap between MR spectroscopic imaging parameters at various Gleason score levels, which may reflect methodologic and physiologic variations. MR spectroscopic imaging has potential in noninvasive assessment of prostate cancer aggressiveness. (author)

  14. A Multi-Criteria Decision Analysis based methodology for quantitatively scoring the reliability and relevance of ecotoxicological data.

    Science.gov (United States)

    Isigonis, Panagiotis; Ciffroy, Philippe; Zabeo, Alex; Semenzin, Elena; Critto, Andrea; Giove, Silvio; Marcomini, Antonio

    2015-12-15

    Ecotoxicological data are highly important for risk assessment processes and are used for deriving environmental quality criteria, which are enacted for assuring the good quality of waters, soils or sediments and achieving desirable environmental quality objectives. Therefore, it is of significant importance the evaluation of the reliability of available data for analysing their possible use in the aforementioned processes. The thorough analysis of currently available frameworks for the assessment of ecotoxicological data has led to the identification of significant flaws but at the same time various opportunities for improvement. In this context, a new methodology, based on Multi-Criteria Decision Analysis (MCDA) techniques, has been developed with the aim of analysing the reliability and relevance of ecotoxicological data (which are produced through laboratory biotests for individual effects), in a transparent quantitative way, through the use of expert knowledge, multiple criteria and fuzzy logic. The proposed methodology can be used for the production of weighted Species Sensitivity Weighted Distributions (SSWD), as a component of the ecological risk assessment of chemicals in aquatic systems. The MCDA aggregation methodology is described in detail and demonstrated through examples in the article and the hierarchically structured framework that is used for the evaluation and classification of ecotoxicological data is shortly discussed. The methodology is demonstrated for the aquatic compartment but it can be easily tailored to other environmental compartments (soil, air, sediments). PMID:26298253

  15. Increased correlation coefficient between the written test score and tutors' performance test scores after training of tutors for assessment of medical students during problem-based learning course in Malaysia.

    Science.gov (United States)

    Jaiprakash, Heethal; Min, Aung Ko Ko; Ghosh, Sarmishtha

    2016-01-01

    This paper is aimed at finding if there was a change of correlation between the written test score and tutors' performance test scores in the assessment of medical students during a problem-based learning (PBL) course in Malaysia. This is a cross-sectional observational study, conducted among 264 medical students in two groups from November 2010 to November 2012. The first group's tutors did not receive tutor training; while the second group's tutors were trained in the PBL process. Each group was divided into high, middle and low achievers based on their end-of-semester exam scores. PBL scores were taken which included written test scores and tutors' performance test scores. Pearson correlation coefficient was calculated between the two kinds of scores in each group. The correlation coefficient between the written scores and tutors' scores in group 1 was 0.099 (phigher correlation coefficient in the group where tutors received the PBL training reinforces the importance of tutor training before their participation in the PBL course. PMID:26838577

  16. Assessing Framingham cardiovascular risk scores in subjects with diabetes and their correlation with diabetic retinopathy

    Directory of Open Access Journals (Sweden)

    Deepali R Damkondwar

    2012-01-01

    Full Text Available Aim: To study the Framingham cardiovascular risk assessment scores in subjects with diabetes and their association with diabetic retinopathy in subjects with diabetes. Materials and Methods: In this population-based prospective study, subjects with diabetes were recruited (n=1248; age ?40 years. The Framingham cardiovascular risk scores were calculated for 1248 subjects with type 2 diabetes. The scores were classified as high risk (>10%, and low risk (<10%. Results: Out of the 1248 subjects, 830 (66.5% patients had a low risk of developing cardiovascular disease (CVD in 10 years and 418 (33.5% had a high risk of developing CVD in 10 years. The risk of developing CVD was more in males than females (56.8% vs. 7% The prevalence of both diabetic retinopathy and sight-threatening retinopathy was more in the high-risk group (21% and 4.5%, respectively. The risk factors for developing diabetic retinopathy were similar in both the groups (low vs. high - duration of diabetes (OR 1.14 vs. 1.08, higher HbA1c (OR 1.24 vs. 1.22, presence of macro- and microalbuminuria (OR 10.17 vs. 6.12 for macro-albuminuria and use of insulin (OR 2.06 vs. 4.38. The additional risk factors in the high-risk group were presence of anemia (OR 2.65 and higher serum high density lipoprotein (HDL cholesterol (OR 1.05. Conclusion: Framingham risk scoring, a global risk assessment tool to predict the 10-year risk of developing CVD, can also predict the occurrence and type of diabetic retinopathy. Those patients with high CVD scores should be followed up more frequently and treated adequately. This also warrants good interaction between the treating physician/cardiologist and the ophthalmologist.

  17. Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores

    Directory of Open Access Journals (Sweden)

    Yoshikazu Kobayashi

    2010-04-01

    Full Text Available Effective R&D and strict quality control of a broad range of foods, beverages, and pharmaceutical products require objective taste evaluation. Advanced taste sensors using artificial-lipid membranes have been developed based on concepts of global selectivity and high correlation with human sensory score. These sensors respond similarly to similar basic tastes, which they quantify with high correlations to sensory score. Using these unique properties, these sensors can quantify the basic tastes of saltiness, sourness, bitterness, umami, astringency and richness without multivariate analysis or artificial neural networks. This review describes all aspects of these taste sensors based on artificial lipid, ranging from the response principle and optimal design methods to applications in the food, beverage, and pharmaceutical markets.

  18. Correlation between Grades in the Medical Basic Science Course and Scores on the Comprehensive Basic Sciences Exam in Iran

    OpenAIRE

    Hamidreza Mahboobi; Ebrahim Khajeh; Nazanin Sharif; Zahra Jahangiri; Tahereh Khorgoei; Keramat Allah Jahanshahi; Mohammad Esmaeil Shahrzad; Elizabeth Cottrell

    2010-01-01

    Introduction: Medical students in Iran are required to undertake a Basic Sciences Comprehensive Exam (BSCE) at the end of their BS course in order to progress to the next stage of medical education. BSCE results are widely used to evaluate medical education programs among different medical universities. The aim of this study is to explore the correlation between BSCE results and students’ mean BS course scores.Methods: A cross-sectional study, using secondary data analysis, was carried out in...

  19. Quantification of Emphysema with a Three-Dimensional Chest CT Scan: Correlation with the Visual Emphysema Scoring on Chest CT, Pulmonary Function Tests and Dyspnea Severity

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyun Jeong; Hwang, Jung Hwa [Dept. of Radiology, Soonchunhyang University Seoul Hospital, Seoul (Korea, Republic of)

    2011-09-15

    We wanted to prospectively evaluate the correlation between the quantification of emphysema using 3D CT densitometry with the visual emphysema score, pulmonary function tests (PFT) and the dyspnea score in patients with chronic obstructive pulmonary disease (COPD). Non-enhanced chest CT with 3D reconstruction was performed in 28 men with COPD (age 54-88 years). With histogram analysis, the total lung volume, mean lung density and proportion of low attenuation lung volume below predetermined thresholds were measured. The CT parameters were compared with the visual emphysema score, the PFT and the dyspnea score. A low attenuation lung volume below -950 HU was well correlated with the DLco and FEV{sub 1}/FVC. A Low attenuation lung volume below -950 HU and -930 HU was correlated with visual the emphysema score. A low attenuation lung volume below -950 HU was correlated with the dyspnea score, although the correlations between the other CT parameters and the dyspnea score were not significant. Objective quantification of emphysema using 3D CT densitometry was correlated with the visual emphysema score. A low attenuation lung volume below -950 HU was correlated with the DLco, the FEV{sub 1}/FVC and the dyspnea score.

  20. Quantification of Emphysema with a Three-Dimensional Chest CT Scan: Correlation with the Visual Emphysema Scoring on Chest CT, Pulmonary Function Tests and Dyspnea Severity

    International Nuclear Information System (INIS)

    We wanted to prospectively evaluate the correlation between the quantification of emphysema using 3D CT densitometry with the visual emphysema score, pulmonary function tests (PFT) and the dyspnea score in patients with chronic obstructive pulmonary disease (COPD). Non-enhanced chest CT with 3D reconstruction was performed in 28 men with COPD (age 54-88 years). With histogram analysis, the total lung volume, mean lung density and proportion of low attenuation lung volume below predetermined thresholds were measured. The CT parameters were compared with the visual emphysema score, the PFT and the dyspnea score. A low attenuation lung volume below -950 HU was well correlated with the DLco and FEV1/FVC. A Low attenuation lung volume below -950 HU and -930 HU was correlated with visual the emphysema score. A low attenuation lung volume below -950 HU was correlated with the dyspnea score, although the correlations between the other CT parameters and the dyspnea score were not significant. Objective quantification of emphysema using 3D CT densitometry was correlated with the visual emphysema score. A low attenuation lung volume below -950 HU was correlated with the DLco, the FEV1/FVC and the dyspnea score.

  1. Correlating PSA, bone scan and Gleason score in prostate cancer patients

    International Nuclear Information System (INIS)

    The hypothesis was that Gleason Score was more important than PSA in predicting bone metastases in prostate cancer patients. The objective of the work was to identify a group of low risk in which bone scan could be omitted. Clinical records of 165 patients with recently diagnosed prostate cancer, who had had, between January of 1993 and December of 1995, bone scans, PSA and Gleason determinations, were reviewed. 5,5% had well differentiated cancer. 49,7% had a negative bone scan. The risk of bone metastases in spite of levels of PSA < 10-20 ng / mL is not worthless in patients with prostate cancer Gleason Score 7-9. (author)

  2. Serum Gamma-Glutamyltransferase Concentration Correlates with Framingham Risk Score in Koreans

    OpenAIRE

    Kim, Kyu-Nam; Kim, Kwang-Min; Lee, Duck-Joo; Joo, Nam-Seok

    2011-01-01

    Gamma-glutamyltransferase (GGT) is a novel coronary artery disease (CAD) risk factor, but its use as an independent factor for CAD risk prediction remains unclear in Asian population. This study examined the association between serum GGT concentration and Framingham risk score (FRS) in the Korean population. This cross-sectional study was performed on 30,710 Koreans. Besides FRS, body mass index, fasting blood glucose, liver enzymes, lipid profile, uric acid and high sensitive C-reactive prot...

  3. Increased Resistin Levels in Intra-abdominal Sepsis: Correlation with proinflammatory cytokines & Acute Physiology & Chronic Health Evaluation II scores

    Directory of Open Access Journals (Sweden)

    Tonguç U. Yilmaz

    2014-10-01

    Full Text Available Objectives: Resistin, a hormone secreted from adipocytes and considered to be a likely cause of insulin resistance, has recently been accepted as a proinflammatory cytokine. This study aimed to determine the correlation between resistin levels in patients with intra-abdominal sepsis and mortality. Methods: Of 45 patients with intraabdominal sepsis, a total of 35 adult patients were included in the study. This study was undertaken from December 2011 to December 2012 and included patients who had no history of diabetes mellitus and who were admitted to the general surgery intensive care units of Gazi University and Bülent Ecevit University School of Medicine, Turkey. Evaluations were performed on 12 patients with sepsis, 10 patients with severe sepsis, 13 patients with septic shock and 15 healthy controls. The patients’ plasma resistin, interleukin-6 (IL-6, tumour necrosis factor alpha (TNF-?, interleukin-1 beta (IL-1?, procalcitonin, lactate and glucose levels and Acute Physiology and Chronic Health Evaluation (APACHE II scores were studied daily for the first five days after admission. A correlation analysis of serum resistin levels with cytokine levels and APACHE II scores was performed. Results: Serum resistin levels in patients with sepsis were significantly higher than in the healthy controls (P <0.001. A significant correlation was found between serum resistin levels and APACHE II scores, serum IL-6, IL-1?, TNF-?, procalcitonin, lactate and glucose levels. Furthermore, a significant correlation was found between serum resistin levels and all-cause mortality (P = 0.02. Conclusion: The levels of resistin were significantly positively correlated with the severity of disease and were a possible mediator of a prolonged inflammatory state in patients with intra-abdominal sepsis.

  4. Correlation between PSA, bone scan and Gleason score in patients with prostate cancer

    International Nuclear Information System (INIS)

    Full text: Prostate cancer is the third most common cancer among Peruvian males. Although radionuclide bone scans (BS) are frequently recommended as part of the staging evaluation for newly diagnosed prostate cancer, most scans are negative for metastases. It has been suggested that a routine bone scan is unnecessary in recently diagnosed prostate cancer if serum PSA is under 10 ng/mL. We hypothesized that Gleason score plus prostate-specific antigen (PSA), could predict for a positive bone scan (better that PSA alone), and that a low - risk group of patients could be identified in whom BS might be omitted. All patients who had both pathologic review of their prostate cancer biopsies and radionuclide BS at our institution from 1/93 to 12/95 were studied. Gleason score, PSA, and bone scan (Soloway Index) were determined in 165 patients. Bivariate analysis using chi (x2) was performed. The mean age of the 165 patients was 71.3 years, 109/165 (66.1%) had a 7-9 Gleason score and only 9/165 (5.5%) were well differentiated prostrate cancer. 82/165 (49.7%) had negative BS. When classifying patients according to their histological grade, the PSA median values were 11.8 ng/mL, 74.8 ng/mL and 116.4 ng/mL in well, median and poorly differentiated prostate cancer respectively. Using a cut off point of 10 ng/mL of PSA, the probability of having a positive BS in Gleason 7, 8 and 9 tumors were 0.109, 0.121 and 0.133 respectively. By using a cut off point of 20 ng/mL of PSA the possibility to have a positive BS in Gleason 7, 8 and 9 tumours were 0.182, 0.206 and 0.224 respectively. Gleason score plus PSA were independent predictors for a positive radionuclide BS in newly diagnosed prostate cancer patients. Considering that most of our patients have Gleason 7-9, the risk of bone metastases despite PSA levels between 10 - 20 ng/mL is not negligible. In our opinion, it is important to continue including bone scan in the staging assessment of prostate cancer. (author)

  5. Severity of acute pulmonary embolism: evaluation of a new spiral CT angiographic score in correlation with echocardiographic data

    Energy Technology Data Exchange (ETDEWEB)

    Mastora, Ioana; Remy-Jardin, Martine; Masson, Pascal; Remy, Jacques [Department of Radiology, University Center Hospital Calmette, Boulevard Jules Leclerc, 59037 Lille Cedex (France); Medical Research Group ' ' Equipe d' Accueil no. 2682' ' , Boulevard Jules Leclerc, 59037 Lille Cedex (France); Galland, Eric; Bauchart, Jean-Jacques [Department of Cardiology, University Center Cardiology Hospital; Boulevard Jules Leclerc, 59037 Lille Cedex (France); Delannoy, Valerie [Department of Medical Statistics, University of Lille, Place de Verdun, 59037 Lille Cedex (France)

    2003-01-01

    The purpose of this study was to investigate whether the severity of acute pulmonary embolism (PE) could be quantitatively assessed with spiral CT angiography (SCTA). Thirty-six consecutive patients without underlying cardiopulmonary disease and high clinical suspicion of PE underwent prospectively thin-collimation SCTA and echocardiography at the time of the initial diagnosis (T0) and after initial therapy (T1; mean interval of time T1-T2: 32 days). The CT severity score was based on the percentage of obstructed surface of each central and peripheral pulmonary arterial section using a 5-point scale (1: <25%; 2: 25-49%; 3: 50-74%; 4: 75-99%; 5: 100%). The sum of the detailed scores attributed to 5 mediastinal, 6 lobar and 20 segmental arteries per patient led to the determination of central, peripheral and global CT severity scores and subsequent determination of percentages of obstruction of the pulmonary circulation. Echocardiographic severity criteria included the presence of signs of acute cor pulmonale and/or systolic pulmonary hypertension (>40 mm Hg). The SCTA depicted acute PE in all patients at T0 with complete resolution of endovascular clots in 10 patients at T1. At T0, the mean percentage of obstruction of the pulmonary arterial bed was significantly higher in the 22 patients with echocardiographic signs of severity (56{+-}13 vs 28{+-}32%; p<0.001). A significant reduction in the mean percentage of pulmonary artery obstruction was observed in the 19 patients with resolution of echocardiographic criteria of severity between T0 and T1 T0: 57{+-}14%; T1: 7{+-}11%; p<0.001. The threshold value for severe PE on CT angiograms was 49% (sensitivity: 0.773; specificity: 0.214). The mean ({+-}SD) pulmonary artery pressure was significantly higher in the 26 patients with more than 50% obstruction of the pulmonary artery bed (45{+-}15 mm Hg) than in the 10 patients with less than 50% obstruction of pulmonary artery bed at T0 (31{+-}11 mm Hg; p<0.01). The CT severity score evaluated in the present study enables quantitative assessment of acute PE severity on spiral CT angiograms, readily applicable in routine clinical practice. (orig.)

  6. Does coronary calcium scoring with a SCORE better predict significant coronary artery stenosis than without? Correlation with computed tomography coronary angiography

    International Nuclear Information System (INIS)

    To determine effectiveness of coronary artery calcium score (CACS) alone and combined with Systematic Coronary Risk Evaluation (SCORE) in adult patients for significant coronary artery stenosis by using computed tomography coronary angiography (CTCA) as reference standard. Two thousand twenty-one patients with suspected coronary artery disease (CAD) underwent CACS test and CTCA. Patients were examined with dual-source CT and were grouped according to their age, gender, CACS, and estimated SCORE risk. Coronary plaque existence and degree of stenosis were assessed with CTCA. Sensitivity, specificity, and ROC curves were analyzed. CACS was the single independent variable in estimating relative risk of critical stenosis and had superior outcome when compared with SCORE risk in logistic regression and ROC curve. Area under the ROC curve was greatest in the interval between 50-59 years. When SCORE was combined with CACS in patients with zero CACS, percentage of significant stenosis increased from 1.4% to 7.0% in patients with high or very high SCORE risk, and decreased to 0.9 % in patients with low or moderate SCORE risk. CACS combination with SCORE risk predicts coronary artery stenosis. When CACS is zero, CTCA can be performed in patients with high or very high SCORE risk. (orig.)

  7. Does coronary calcium scoring with a SCORE better predict significant coronary artery stenosis than without? Correlation with computed tomography coronary angiography

    Energy Technology Data Exchange (ETDEWEB)

    Durhan, Gamze; Hazirolan, Tuncay; Karcaaltincaba, Musturay; Akata, Deniz [Hacettepe University Medical School, Department of Radiology, Ankara (Turkey); Sunman, Hamza; Aytemir, Kudret [Hacettepe University Medical School, Department of Cardiology, Ankara (Turkey); Karakaya, Jale; Karaagaoglu, Ergun [Hacettepe University, Department of Biostatistics, Ankara (Turkey)

    2014-12-03

    To determine effectiveness of coronary artery calcium score (CACS) alone and combined with Systematic Coronary Risk Evaluation (SCORE) in adult patients for significant coronary artery stenosis by using computed tomography coronary angiography (CTCA) as reference standard. Two thousand twenty-one patients with suspected coronary artery disease (CAD) underwent CACS test and CTCA. Patients were examined with dual-source CT and were grouped according to their age, gender, CACS, and estimated SCORE risk. Coronary plaque existence and degree of stenosis were assessed with CTCA. Sensitivity, specificity, and ROC curves were analyzed. CACS was the single independent variable in estimating relative risk of critical stenosis and had superior outcome when compared with SCORE risk in logistic regression and ROC curve. Area under the ROC curve was greatest in the interval between 50-59 years. When SCORE was combined with CACS in patients with zero CACS, percentage of significant stenosis increased from 1.4% to 7.0% in patients with high or very high SCORE risk, and decreased to 0.9 % in patients with low or moderate SCORE risk. CACS combination with SCORE risk predicts coronary artery stenosis. When CACS is zero, CTCA can be performed in patients with high or very high SCORE risk. (orig.)

  8. Feeding practices correlated with authoritative parenting style and responsive feeding style scores

    Science.gov (United States)

    Study objective was to identify correlations of authoritative parenting and responsive feeding styles with parental practices and child behaviors previously found to protect children from or increase risk of child obesity. Participants were 144 low-income mothers of 3- to 5-year-old children (71 gir...

  9. Short communication: Genetic correlation of bovine leukosis incidence with somatic cell score and milk yield in a US Holstein population.

    Science.gov (United States)

    Abdalla, E A; Weigel, K A; Byrem, T M; Rosa, G J M

    2016-03-01

    Bovine leukosis (BL) is a retroviral disease caused by the bovine leukosis virus (BLV), which affects only cattle. Dairy cows positive for BL produce less milk and have more days open than cows negative for BL. In addition, the virus also affects the immune system and causes weaker response to vaccines. Heritability estimates of BL incidence have been reported for Jersey and Holstein populations at about 0.08, indicating an important genetic component that can potentially be exploited to reduce the prevalence of the disease. However, before BL is used in selection programs, it is important to study its genetic associations with other economically important traits such that correlated responses to selection can be predicted. Hence, this study aimed to estimate the genetic correlations of BL with milk yield (MY) and with somatic cell score (SCS). Data of a commercial assay (ELISA) used to detect BLV antibodies in milk samples were obtained from Antel BioSystems (Lansing, MI). The data included continuous milk ELISA scores and binary milk ELISA results for 11,554 cows from 112 dairy herds across 16 US states. Continuous and binary milk ELISA were analyzed with linear and threshold models, respectively, together with MY and SCS using multitrait animal models. Genetic correlations (posterior means ± standard deviations) between BL incidence and MY were 0.17±0.077 and 0.14±0.076 using ELISA scores and results, respectively; with SCS, such estimates were 0.20±0.081 and 0.17±0.079, respectively. In summary, the results indicate that selection for higher MY may lead to increased BLV prevalence in dairy herds, but that the inclusion of BL (or SCS as an indicator trait) in selection indexes may help attenuate this problem. PMID:26778307

  10. Big Macs and Eigenfactor Scores: Don't Let Correlation Coefficients Fool You

    OpenAIRE

    West, Jevin; Bergstrom, Theodore; Bergstrom, Carl

    2009-01-01

    The Eigenfactor Metrics provide an alternative way of evaluating scholarly journals based on an iterative ranking procedure analogous to Google's PageRank algorithm. These metrics have recently been adopted by Thomson-Reuters and are listed alongside the Impact Factor in the Journal Citation Reports. But do these metrics differ sufficiently so as to be a useful addition to the bibliometric toolbox? Davis (2008) has argued otherwise, based on his finding of a 0.95 correlation...

  11. Rheumatoid arthritis bone erosion volumes on CT and MRI: reliability and correlations with erosion scores on CT, MRI and radiography

    DEFF Research Database (Denmark)

    Møller Døhn, Uffe; Ejbjerg, Bo J; Hasselquist, Maria; Narvestad, Eva; Court-Payen, Michel; Szkudlarek, Marcin; Møller, Jakob; Thomsen, Henrik S; Østergaard, Mikkel

    2007-01-01

    controls underwent unilateral CT, MRI and radiography of second to fifth MCP joints in one hand. Erosion volumes (using OSIRIS software) and scores were determined from CT, MRI and radiography (scores only). RESULTS: CT, MRI and radiography detected 77, 62 and 12 erosions, respectively. On CT, the mean......OBJECTIVES: To investigate intramodality and intermodality agreements of CT and MRI erosion volumes in metacarpophalangeal (MCP) joints in rheumatoid arthritis (RA), and to compare the volumes with erosion scores for CT, MRI and radiography. METHODS: In total, 17 patients with RA and four healthy...... erosion volume was 26 mm(3) (median 10; range 0 to 248) and 30 mm(3) (18; 1 to 163) on MRI. Total erosion volumes (per patient/control) were 97 mm(3) (29; 0 to 485) on CT and 90 mm(3) (46; 0 to 389) on MRI. For volumes, Spearman correlation coefficients were 0.96 to 0.99 (CT vs CT), 0.95 to 0.98 (MRI vs...

  12. Time course of lesion development in patients with acute brain stem infarction and correlation with NIHSS score

    International Nuclear Information System (INIS)

    Background and purpose: diffusion weighted magnetic resonance imaging (MRI) is highly sensitive in detecting acute supratentorial cerebral ischemia and Diffusion Weighted Imaging (DWI) lesion size has been shown to correlate strongly with the neurologic deficit in middle cerebral artery territory stroke. However, data concerning infratentorial strokes are rare. We examined the size and evolution of acute brain stem ischemic lesions and their relationship to neurological outcome. Methods: brain stem infarctions of 11 patients were analyzed. We performed DWI in all patients and in 7/11 patients within 24 h, T2W sequences within the first 2 weeks (10/11 patients) and follow-up MRI (MR2) within 3-9 months (median 4.8 months) later (12/12 patients). Lesion volumes were compared with early and follow-up neurologic deficit as determined by National Institutes of Health Stroke Scale (NIHSS) score. Results: the relative infarct volumes--with MR2 lesion size set to 100%--decreased over the time (P<0.02) with a mean shrinking factor of 3.3 between DWI (MR0) and the follow-up MRT (P<0.02), and 1.6 between early T2W (MR1) and MR2 (P<0.04). The mean DWI volume size (MR0) was larger than the early T2W (P<0.02). Although neurological outcome was good in all patients (mean NIHSS score of 1.3 at follow-up), early NIHSS and follow-up NIHSS scores were strongly correlated (r=0.9, P<0.00). NIHSS score at follow-up was highly correlated with lesion size of DWI (MR0; r=0.71, P<0.04) and T2W of MR1 (r=0.86, P<0.001). Conclusions: in this study, we saw a shrinking of the brain stem infarct volume according to clinical improvement of patients. Great extension of restricted diffusion in the acute stage does not necessarily implicate a large resulting infarction or a bad clinical outcome

  13. Time course of lesion development in patients with acute brain stem infarction and correlation with NIHSS score

    Energy Technology Data Exchange (ETDEWEB)

    Fitzek, Sabine E-mail: sabine.fitzek@med.uni-jena.de; Fitzek, Clemens; Urban, Peter Paul; Marx, Juergen; Hopf, Hanns Christian; Stoeter, Peter

    2001-09-01

    Background and purpose: diffusion weighted magnetic resonance imaging (MRI) is highly sensitive in detecting acute supratentorial cerebral ischemia and Diffusion Weighted Imaging (DWI) lesion size has been shown to correlate strongly with the neurologic deficit in middle cerebral artery territory stroke. However, data concerning infratentorial strokes are rare. We examined the size and evolution of acute brain stem ischemic lesions and their relationship to neurological outcome. Methods: brain stem infarctions of 11 patients were analyzed. We performed DWI in all patients and in 7/11 patients within 24 h, T2W sequences within the first 2 weeks (10/11 patients) and follow-up MRI (MR2) within 3-9 months (median 4.8 months) later (12/12 patients). Lesion volumes were compared with early and follow-up neurologic deficit as determined by National Institutes of Health Stroke Scale (NIHSS) score. Results: the relative infarct volumes--with MR2 lesion size set to 100%--decreased over the time (P<0.02) with a mean shrinking factor of 3.3 between DWI (MR0) and the follow-up MRT (P<0.02), and 1.6 between early T2W (MR1) and MR2 (P<0.04). The mean DWI volume size (MR0) was larger than the early T2W (P<0.02). Although neurological outcome was good in all patients (mean NIHSS score of 1.3 at follow-up), early NIHSS and follow-up NIHSS scores were strongly correlated (r=0.9, P<0.00). NIHSS score at follow-up was highly correlated with lesion size of DWI (MR0; r=0.71, P<0.04) and T2W of MR1 (r=0.86, P<0.001). Conclusions: in this study, we saw a shrinking of the brain stem infarct volume according to clinical improvement of patients. Great extension of restricted diffusion in the acute stage does not necessarily implicate a large resulting infarction or a bad clinical outcome.

  14. Distribution of brain infarction in children with tuberculous meningitis and correlation with outcome score at 6 months

    International Nuclear Information System (INIS)

    Prognostic indicators for tuberculous meningitis (TBM) offer realistic expectations for parents of affected children. Infarctions affecting the basal ganglia are associated with a poor outcome. To correlate the distribution of infarction in children with TBM on CT with an outcome score (OS). CT brain scans in children with TBM were retrospectively reviewed and the distribution of infarctions recorded. The degree of correlation with OS at 6 months was determined. There was a statistically significant association between all sites of infarction (P = 0.0001-0.001), other than hemispheric (P = 0.35), and outcome score. There was also a statistically significant association between all types of infarction (P = 0.0001-0.02), other than hemispheric (P = 0.05), and overall poor outcome. The odds ratio for poor outcome with bilateral basal ganglia and internal capsule infarction was 12. The odds ratio for poor outcome with 'any infarction' was 4.91 (CI 2.24-10.74), with 'bilateral infarctions' 8.50 (CI 2.49-28.59), with basal ganglia infarction 5.73 (CI 2.60-12.64), and for hemispheric infarction 2.30 (CI 1.00-5.28). Infarction is associated with a poor outcome unless purely hemispheric. MRI diffusion-weighted imaging was not part of this study, but is likely to play a central role in detecting infarctions not demonstrated by CT. (orig.)

  15. Correlation between electrical conductivity and somatic cell score for mastitis evaluation in dairy Gir cattle

    Directory of Open Access Journals (Sweden)

    Ingrid Borges Valdevite

    2012-12-01

    Full Text Available Mastitis is an inflammation of the mammary gland, caused by bacteria, viruses, fungi and yeasts. During the processes of inflammation, chloride (Cl and sodium (Na ions, immunoglobulins and other serum proteins present in blood, flow through capillaries direct to the alveoli lumen of the gland, thus increasing its concentration. This is due to the increase of vascular permeability, the destruction of tight junctions and the active ion-pumping system, while the concentration of casein, lactose, triglycerides and potassium (K decreases. This work aimed to study a method to evaluate mastitis in Gir dairy cattle, where the milk electric conductivity (EC was correlated to milk somatic cell count (SCC. This method will provide an early diagnosis, which can be used daily with conductivity meter in mechanical milking machine or weekly in properties with manual milking. The measurement of EC in milk was accomplished through the appliance of AK83 BENCHTOP PORTATIL. The experiment was conducted in two farms: Calciolândia, Arcos/MG and Bom Jardim da Serra, Mococa/SP, totaling 123 Gir cows. In Calciolândia farm, milking was manual and in Bom Jardim da Serra milking was manual and mechanical but both with the presence of the calf . The milk collection took place in 10 ml bottles at ambience temperature, and the samples were in duplicate, one to measure the EC and the other for SCC and components. The correlations were calculated using SAS software, through data collected from farms. The correlations found between EC and SCC were 40.9% and 42.7%, respectively to Bom Jardim da Serra and Calciolândia farms. Environmental factors that influences SCC and EC where not considered in the analysis, order of birth, lactation stage, age of cow, number of milk per day and jet of milk collected sample of complete collection of first milking or jets of milk. For now we can conclude that there is strong evidence of an analogy between electrical current (EC and the milk somatic cell count (SCC, where the EC increases during inflammation and SCC, but one is the amount of other ions and by increased presence of cells in milk. This method can replace the SCC, reducing the cost of laboratory tests with a quick, efficient and inexpensive measurement.

  16. Severity of acute pulmonary embolism: evaluation of a new spiral CT angiographic score in correlation with echocardiographic data

    International Nuclear Information System (INIS)

    The purpose of this study was to investigate whether the severity of acute pulmonary embolism (PE) could be quantitatively assessed with spiral CT angiography (SCTA). Thirty-six consecutive patients without underlying cardiopulmonary disease and high clinical suspicion of PE underwent prospectively thin-collimation SCTA and echocardiography at the time of the initial diagnosis (T0) and after initial therapy (T1; mean interval of time T1-T2: 32 days). The CT severity score was based on the percentage of obstructed surface of each central and peripheral pulmonary arterial section using a 5-point scale (1: 40 mm Hg). The SCTA depicted acute PE in all patients at T0 with complete resolution of endovascular clots in 10 patients at T1. At T0, the mean percentage of obstruction of the pulmonary arterial bed was significantly higher in the 22 patients with echocardiographic signs of severity (56±13 vs 28±32%; p<0.001). A significant reduction in the mean percentage of pulmonary artery obstruction was observed in the 19 patients with resolution of echocardiographic criteria of severity between T0 and T1 T0: 57±14%; T1: 7±11%; p<0.001. The threshold value for severe PE on CT angiograms was 49% (sensitivity: 0.773; specificity: 0.214). The mean (±SD) pulmonary artery pressure was significantly higher in the 26 patients with more than 50% obstruction of the pulmonary artery bed (45±15 mm Hg) than in the 10 patients with less than 50% obstruction of pulmonary artery bed at T0 (31±11 mm Hg; p<0.01). The CT severity score evaluated in the present study enables quantitative assessment of acute PE severity on spiral CT angiograms, readily applicable in routine clinical practice. (orig.)

  17. HER2 Amplification in Gastroesophageal Adenocarcinoma: Correlation of Two Antibodies Using Gastric Cancer Scoring Criteria, H Score, and Digital Image Analysis With Fluorescence In Situ Hybridization

    OpenAIRE

    Radu, Oana M.; Foxwell, Tyler; Cieply, Kathleen; Navina, Sarah; Dacic, Sanja; Nason, Katie S.; Davison, Jon M.

    2012-01-01

    We assessed 103 resected gastroesophageal adenocarcinomas for HER2 amplification by fluorescence in situ hybridization (FISH) and 2 commercial immunohistochemical assays. Of 103, 30 (29%) were FISH-amplified. Both immunohistochemical assays had greater than 95% concordance with FISH. However, as a screening test for FISH amplification, the Ventana Medical Systems (Tucson, AZ) 4B5 antibody demonstrated superior sensitivity (87%) compared with the DAKO (Carpinteria, CA) A0485 (70%). Of the case...

  18. The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system      and the EORTC quality of life questionnaires

    DEFF Research Database (Denmark)

    Jensen, Kenneth; Jensen, Anders Bonde

    2006-01-01

    BACKGROUND AND PURPOSE: Morbidity is an important issue in cancer       research. The observer-based toxicity scoring system used by DAHANCA (the       Danish head and neck cancer study group) has proved itself sensitive to       differences in toxicity in a large randomised study, but like other       toxicity scoring systems it has not been formally validated. Conversely,       the EORTC quality of life questionnaire (QLQ) has been validated as a tool       for collecting information about the consequences of disease and treatment       on the well being of cancer patients. The purpose of this study was to       examine the relationship between the two methods of side effect recording.       PATIENTS AND METHODS: One hundred and sixteen recurrence free patients       with laryngeal (n=44), pharyngeal (n=34) and oral cavity (n=38) cancer       attending follow-up after radiotherapy (n=83) or surgery (n=33) completed       EORTC C30, the core questionnaire concerning general symptoms and function       and EORTC H&N35 the head and neck specific questionnaire. The attending       physicians in the follow-up clinic evaluated and recorded DAHANCA toxicity       scores on the same patients. RESULTS: The DAHANCA toxicity scoring system       and the EORTC QLQ correlated with several clinical endpoints. The       conceptually similar endpoints of the two methods correlated       significantly. The objective endpoints of the DAHANCA scoring system were       only correlated with quality of life endpoints to a very low degree. The       DAHANCA toxicity scores had a low sensitivity (0.48-0.74) in detecting       equivalent subjective complaints from the questionnaires and the       observer-based scoring system severely underestimated patient complaints.       A specific patient group where the DAHANCA score had a higher tendency to       fail could not be detected. CONCLUSION: The DAHANCA toxicity score is an       effective instrument in assessing objective treatment induced toxicity in       head and neck cancer patients but insensitive and non-specific with regard       to patient assessed subjective endpoints. This weakness seems inherent in       an observer-based scoring system, and will probably also apply to newer       ones like CTCAE 3.0

  19. The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system and the EORTC quality of life questionnaires

    DEFF Research Database (Denmark)

    Jensen, Kenneth; Bonde Jensen, Anders

    2006-01-01

    BACKGROUND AND PURPOSE: Morbidity is an important issue in cancer research. The observer-based toxicity scoring system used by DAHANCA (the Danish head and neck cancer study group) has proved itself sensitive to differences in toxicity in a large randomised study, but like other toxicity scoring systems it has not been formally validated. Conversely, the EORTC quality of life questionnaire (QLQ) has been validated as a tool for collecting information about the consequences of disease and treatment on the well being of cancer patients. The purpose of this study was to examine the relationship between the two methods of side effect recording. PATIENTS AND METHODS: One hundred and sixteen recurrence free patients with laryngeal (n=44), pharyngeal (n=34) and oral cavity (n=38) cancer attending follow-up after radiotherapy (n=83) or surgery (n=33) completed EORTC C30, the core questionnaire concerning general symptoms and function and EORTC H&N35 the head and neck specific questionnaire. The attending physicians in the follow-up clinic evaluated and recorded DAHANCA toxicity scores on the same patients. RESULTS: The DAHANCA toxicity scoring system and the EORTC QLQ correlated with several clinical endpoints. The conceptually similar endpoints of the two methods correlated significantly. The objective endpoints of the DAHANCA scoring system were only correlated with quality of life endpoints to a very low degree. The DAHANCA toxicity scores had a low sensitivity (0.48-0.74) in detecting equivalent subjective complaints from the questionnaires and the observer-based scoring system severely underestimated patient complaints. A specific patient group where the DAHANCA score had a higher tendency to fail could not be detected. CONCLUSION: The DAHANCA toxicity score is an effective instrument in assessing objective treatment induced toxicity in head and neck cancer patients but insensitive and non-specific with regard to patient assessed subjective endpoints. This weakness seems inherent in an observer-based scoring system, and will probably also apply to newer ones like CTCAE 3.0.

  20. Lack of a correlation between micronucleus scores in cytokinesis - blocked lymphocytes and cancer patient response to radiotherapy

    International Nuclear Information System (INIS)

    In the present study, we have used a retrospective approach in order to investigate a range of radiosensitivities measured by micronucleus (Mn) assay in lymphocytes of head and neck, and cervix cancer patients. There were treatment failures and tumor free patients in both groups. The aim therefore was to establish the possible role of MN scores in identifying these different responses. Peripheral blood samples were collected from 15 patients for head and neck cancer group, and from 16 patients for cervix group. The samples were irradiated with 3 Gy of Co-60 gamma irradiation. Micronucleus values which determine the cellular radiosensitivity ranged between 0.03 and 0.39 with the average value of 0.23 for head and neck cancer patients and ranged between 0.05 and 0.48 with the average value of 0.25. Statistically, there was no difference between radiosensitivity of two patients groups (p=0.33). In cervix cancer group, there were four treatment failure patients and there were six treatment failure patients in head and neck cancer group. MN frequencies of all the failure patients generated more micronuclei following in vitro test irradiation and were above the average sensitivity value of 0.25. The results in the present paper provide an evidence that although we investigated two different cancer groups, the quantitative similarities in the radiosensitivity range measured by MN assay exist. However, within the radiosensitivity range of each group, there was lack of a correlation between MN scores and patient response. It could be concluded that MN test applied to lymphocytes does not have a predictive value in patient prognosis. (authors)

  1. Biochemical Indices and Sensory Scores of Kunu-zaki Beverages Produced from Sprouted and Unsprouted Guinea Corn and Their Correlations

    Directory of Open Access Journals (Sweden)

    C.O. Ibegbulem

    2014-01-01

    Full Text Available Kunu-zaki beverage is a popular cereal-grain based non-alcoholic drink traditionally produced from sprouted cereal grains like sorghum, millet, maize or their mixtures. Unsprouted grains can also be used, thereby saving time spent during sprouting without compromising sensory property. The present study sought to investigate, in comparative terms, the biochemical indices and sensory scores of Kunu-zaki beverages produced from Sprouted Guinea Corn (SGC and Unsprouted Guinea Corn (USGC as well as establishing correlation between these parameters. Production of Kunu-zaki beverages from USGC and SGC was carried out using standard procedures. Samples of the beverages were analyzed for glucose, protein and hydrogen ion concentrations in concurrence with sensory evaluation scores. The results indicated that the Kunu-zaki beverages produced were of comparable (p>0.05 acidity values. Protein and glucose concentrations of Kunu-zaki beverage produced from SGC were significantly higher (p Kunu-zaki beverage produced from SGC gave: [protein] = 10.6±2.62 g L-1 and [glucose] = 500.0±4.90 mg dL-1, whereas beverage produced from USGC gave [protein] = 3.0 g L-1 and [glucose] = 335.3±2.8 mg dL-1. Sensory attributes of the beverages were not significantly different (p>0.05. The pH, mouthfeel, protein and glucose contents of the beverages had strong positive effects on their tastes. The protein content of Kunu-Zaki beverage produced from SGC had marginal effect on its taste. Although the levels of some biochemical parameters were reduced when Kunu-zaki beverage was produced from USGC, it did not affect its sensory property.

  2. Development and validation of modified disease activity scores in rheumatoid arthritis : superior correlation with magnetic resonance imaging-detected synovitis and radiographic progression

    DEFF Research Database (Denmark)

    Baker, Joshua F; Conaghan, Philip G

    2014-01-01

    OBJECTIVE: To develop and validate composite disease activity scores, based on widely available clinical measures, that would demonstrate improved correlation with detection of synovitis on magnetic resonance imaging (MRI) and radiographic progression, in comparison with conventional measures, in patients with rheumatoid arthritis (RA). METHODS: This study was conducted as a secondary study of 2 RA clinical trials, GO-BEFORE (development cohort) and GO-FORWARD (validation cohort). Generalized estimating equations were used to evaluate independent cross-sectional associations of component variables (from all time points) with concurrent MRI measures of synovitis and bone edema in the development cohort. Based on regression coefficients, modified versions of the Disease Activity Score in 28 joints (M-DAS28), Simplified Disease Activity Index (M-SDAI), and Clinical Disease Activity Index (M-CDAI) were generated for each subject in the validation cohort. The M-DAS28, M-SDAI, and M-CDAI scores were compared to conventional scores of disease activity with regard to associations with MRI measures of synovitis and radiographic progression, assessed using Pearson's and Spearman's correlations, linear/logistic regression, and receiver operating characteristic analysis. RESULTS: Four variables were independently associated with MRI-detected synovitis and bone edema in the development cohort: C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), swollen joint count in 28 joints (SJC28), and evaluator's global assessment of disease activity using a visual analog scale (EvGA score). Modified disease activity scores were generated using the regression coefficients obtained in the synovitis models for all subjects in the validation cohort; modified scores were calculated as M-DAS28 = 0.49 × ln(CRP) + 0.15 × SJC28 + 0.22 × EvGA + 1 and M-SDAI = CRP + SJC28 + EvGA. Both modified and conventional disease activity scores correlated significantly with MRI measures of synovitis. Modified scores showed superior correlation with synovitis, as compared to conventional scores, at all time points (P < 0.05). Furthermore, the M-DAS28 and M-SDAI had superior test characteristics for prediction of radiographic progression at 52 weeks (both P < 0.05). CONCLUSION: Modified disease activity scores demonstrated superior correlation with MRI detection of synovitis at all time points, and more accurately predicted radiographic progression in patients with RA in a clinical trial setting.

  3. Refining criteria for diagnosis of cutaneous infections caused by herpes viruses through correlation of morphology with molecular pathology

    Directory of Open Access Journals (Sweden)

    Böer Almut

    2006-01-01

    Full Text Available BACKGROUND: Infections of the skin by herpes viruses do not always present themselves in typical fashion. Early diagnosis, however, is crucial for appropriate treatment. Polymerase chain reaction (PCR allows diagnosis and differential diagnosis of herpes virus infections, but the method is not yet available in large parts of the world, where diagnosis is made based on morphology alone. AIM: To refine criteria for the diagnosis of herpes virus infections of the skin by way of correlation of clinical and histopathologic findings with results of PCR studies. METHODS: We studied 75 clinically diagnosed patients of "zoster," "varicella," and "herpes simplex", to correlate clinical and histopathological findings with results of PCR studies on paraffin embedded biopsy specimens. RESULTS: Clinical suspicion of infection by herpes viruses was confirmed by histopathology in 37% of the cases and by PCR studies in 65% of the cases. Zoster was frequently misdiagnosed as infection with herpes simplex viruses (30%. When diagnostic signs of herpes virus infection were encountered histopathologically, PCR confirmed the diagnosis in 94%. By way of correlation with results of PCR studies, initial lesions of herpes virus infections could be identified to have a distinctive histopathological pattern. Herpetic folliculitis appeared to be a rather common finding in zoster, it occurring in 28% of the cases. CONCLUSION: We conclude that correlation of clinical and histopathological features with results of PCR studies on one and the same paraffin embedded specimen permits identification of characteristic morphologic patterns and helps to refine criteria for diagnosis both clinically and histopathologically.

  4. Comparisons of bone mass measurements on various skeletal sites including quantitative ultrasonography of the calcaneus for assessing age-related losses, their correlations, and diagnostic agreement using the Japanese and WHO criteria for osteoporosis

    International Nuclear Information System (INIS)

    The aim of this study was to compare age-related bone losses and correlations among several bone mass measurements and to evaluate diagnostic agreement among them using the Japanese and World Health Organization (WHO) criteria for osteoporosis. A total of 846 women (mean±standard deviation (SD): age 54±9 years) were evaluated. Bone mineral densities of the lumbar spine, femoral neck, and calcaneus were measured by dual X-ray absorptiometry and distal radius by peripheral computed tomography. Quantitative ultrasonography (QUS) parameters of the calcaneus were also measured. The age-related bone losses after 50 years of age and correlations among bone mass results were evaluated using linear regression analysis. Diagnostic agreement was evaluated by kappa statistics. The annual losses ranged from 1.0% to 1.6%. The correlation coefficients ranged from 0.54 to 0.78. The kappa scores ranged from 0.52 to 0.30 for all subjects using the Japanese criteria and from 0.38 to 0.15 using the WHO criteria. Bone mass measurements including QUS on various skeletal sites documented age-related changes similarly, and their bone masses correlated moderately. The diagnostic agreements among them were fair to poor. To screen out women with a risk of osteoporosis, it is important to choose which technique to use and which skeletal site to measure. (author)

  5. Correlation between serum ferritin levels and attention-deficit/hyperactivity disorder symptom scores in children based on the Abbreviated Conners Teachers Rating Scale

    Directory of Open Access Journals (Sweden)

    Intan Alita Putri Tumbelaka

    2014-10-01

    Full Text Available Background Dopamine deficiency is thought to be one of the factors causing attention-deficit /hyperactivity disorder (ADHD in children. Iron contributes to the regulation of dopamine neurotransmitter activity, thus, iron deficiency has been associated with ADHD. Several studies have been conducted in other countries to assess for a correlation between serum ferritin levels and ADHD symptom scores, but with varied results. Objective To examine the relationship between iron deficiency and ADHD symptoms, in particular the correlation between serum ferritin levels and Abbreviated Conners Teachers Rrating Scale (ACTRS scores in children with ADHD. Methods This cross-sectional study was performed in children aged 5-12 years who were newly diagnosed with ADHD. Subjects were recruited from the Klinik Anakku Kelapa Gading, the Neurology Outpatient Clinic, the Growth and Development-Social Pediatrics Clinic, and the Integrated Child Clinic of Cipto Mangunkusumo Hospital. ADHD diagnoses were established using Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSMm-IV. Subjects’ parents and teachers were asked to complete the ACTRS instrument sheet. Venous blood specimens were obtained for peripheral blood and serum ferritin level tests. Results Of the 33 subjects recruited, 23 were male. Subjects’ ages ranged from 5-12 years, with a median age of onset of 4 (range 2-10 years. The combined type of ADHD (with inattention and hyperactivity-impulsivity was more commonly found (20/33 in our subjects. The mean serum ferritin was 51.31 (SD 27.7 ng/mL. Using 20 ng/mL as the serum ferritin cutoff value, 5/33 subjects were considered to be iron deficient. Median ACTRS score by parents and teachers were 15 and 15, respectively. Higher scores were found in the combined type subject group than in the inattention type subject group. Mmedian serum ferritin levels of the two ADHD type groups were similar. ACTRS scores of parents and teachers tended to be higher in the iron-deficient group (16 and 16, respectively than in the normal serum iron group (14.5 and 12.5, respectively. Serum ferritin level showed no correlation (r=-0.243; P=0.086 to the parents’ ACTRS score, and no correlation (r=-.057; P=0.377 to the teachers’ ACTRrS score. Conclusion Serum ferritin level showed no correlation to ACTRS scores of parents and teachers, respectively. However, the median ACTRS score was higher in the iron-deficiency group than in the normal iron status group, suggesting that there may be a qualitative relationship between iron deficiency and ADHD symptoms.

  6. Performance of chromogenic in situ hybridization on testing HER2 Status in breast carcinomas with chromosome 17 polysomy and equivocal (2+) herceptest results: a study of two institutions using the conventional and new ASCO/CAP scoring criteria.

    Science.gov (United States)

    Gong, Yun; Sweet, William; Duh, Yi-Jing; Greenfield, Larry; Tarco, Emily; Trivedi, Smita; Symmans, W Fraser; Isola, Jorma; Sneige, Nour

    2009-08-01

    This study specifically addressed the performance of chromogenic in situ hybridization (CISH) on HER2 testing in 66 breast carcinomas with chromosome 17 polysomy and 49 carcinomas with an equivocal HercepTest (DakoCytomation, Carpinteria, CA) score by comparing CISH with corresponding FISH results at 2 test sites and evaluating intersite agreement of CISH results. For tumors with chromosome 17 polysomy, when using the manufacturers' criteria, the concordance values between CISH and FISH at site A, site B, and intersite CISH agreement were 95.8%, 95.5%, and 93.5%, respectively; when using the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) criteria, the values were 100.0%, 100.0%, and 100.0%, respectively. For tumors with an equivocal HercepTest score, when using the manufacturers' criteria, the concordance values between the 2 methods at site A, site B, and intersite CISH agreement were 88.2%, 95.1%, and 91.1%, respectively; when using the ASCO/CAP criteria, the values were 96.7%, 97.3%, and 97.4%, respectively. These results indicate that CISH is reliable for testing these 2 types of tumors, especially when the ASCO/CAP criteria are used. PMID:19605817

  7. Could near-infrared Raman spectroscopy be correlated with the METAVIR scores in liver lesions induced by hepatitis C virus?

    Science.gov (United States)

    Gaggini, Marcio Cesar Reino; Navarro, Ricardo Scarparo; Stefanini, Aline Reis; Sano, Rubens Sato; Silveira, Landulfo

    2013-03-01

    The liver is responsible for several basic functions in human body how the syntheses of the most main proteins and degradation process of toxins, drugs and alcohols. In present days, the viral hepatitis C is one of the highest causes of chronic hepatic illness worldwide, affecting around 3% of the world population. The liver biopsy is considered the gold standard for diagnosing hepatic fibrosis; however, the biopsies may be questioned because of potential sampling error, morbidity, possible mortality and relatively high costs. Spectroscopy techniques such as Raman spectroscopy have been used for diagnosis of human tissues, with favorable results. Raman spectroscopy has been employed to distinguish normal from hepatic lesions through spectral features mainly of proteins, nucleic acids and lipids. In this study, eleven patients with diagnoses of chronic hepatitis C underwent hepatic biopsies having two hepatic fragments collected: one was scored through METAVIR system and the other one was submitted to near-infrared Raman spectroscopy using a dispersive spectrometer (830 nm wavelength, 300 mW laser power and 20 s exposure time). Five spectra were collected in each fragment and submitted to Principal Components Analysis (PCA). Results showed a good correlation between the Raman spectroscopy features and the stage of hepatic fibrosis and inflammation. PCA showed that samples with higher degree of fibrosis presented higher amount of protein features (collagen), whereas samples of higher degree of inflammation presented higher features of hemoglobin, in accordance to the expected evolution of the chronic hepatitis. It has been found an important biomarker for the beginning of hepatic lesion (quinone) with a spectral feature at 1595 cm-1.

  8. Complex versus Simple Modeling for DIF Detection: When the Intraclass Correlation Coefficient (?) of the Studied Item Is Less Than the ? of the Total Score

    Science.gov (United States)

    Jin, Ying; Myers, Nicholas D.; Ahn, Soyeon

    2014-01-01

    Previous research has demonstrated that differential item functioning (DIF) methods that do not account for multilevel data structure could result in too frequent rejection of the null hypothesis (i.e., no DIF) when the intraclass correlation coefficient (?) of the studied item was the same as the ? of the total score. The current study extended…

  9. Correlation of the modified Glasgow coma scale and Ramsay sedation scale scores with bispectral index monitoring in unconscious critically ill patients

    Directory of Open Access Journals (Sweden)

    Elif Bombac?

    2005-01-01

    Full Text Available Objective: Monitoring critically ill patients with a decreased level of consciousness is challenging. It is suggested that bispectral index monitoring (BIS may be useful in the assessment of neurologic functions for critical care patients because simplicity is its essence. The aim of this randomised, prospective study was to assess the correlation of BIS with the Glasgow coma score modified by Cook and Palma (GCSC and Ramsay sedation scale (RSS for the measurement of neurologic status in critically ill patients. Material and Methods: Thirty-eight patients ranged from 15 to 65 years of age were evaluated for level of consciousness using BIS, GCSC and RSS in addition to standard intensive care monitorization. Spearman’s correlation coefficient was used to correlate the BIS scores with clinical scales. Results: BIS values correlated significantly with RSS (r= -0,388; p= 0,016 and GCSC (r= 0,629; p= 0,001. GCSC was significantly correlated with RSS (r= -0,518; p= 0,001. Conclusion: It was concluded that BIS is suitable for monitoring the neurologic status in unsedated critically ill patients. BIS was well correlated with the clinical assessment based on various scores.

  10. Fatal Kawasaki disease with incomplete criteria: Correlation between optical coherence tomography and pathology.

    Science.gov (United States)

    Dionne, Audrey; Kokta, Victor; Chami, Rose; Morissette, Geneviève; Dahdah, Nagib

    2015-12-01

    Coronary artery aneurysm is a serious complication of Kawasaki disease (KD). A 3-month-old infant presented with severe KD 27 days after onset of fever. The patient presented with shock, inferolateral ischemia on electrocardiogram and high troponin. Echocardiography showed severe myocardial dysfunction with diffuse coronary dilation and right coronary artery aneurysm. Arterial Doppler demonstrated thrombosis of aneurysmal axillary and iliac arteries. Withdrawal of support was implemented due to multi-organ failure. Post-mortem optical coherence tomography correlated with pathology. The pulmonary artery was normal on OCT and histology. Coronary arteries showed aneurysmal dilatation, with intimal hyperplasia and preserved media on OCT. Pathology confirmed these findings, with destruction of the internal elastic lamina, luminal myofibroblastic proliferation, neovascularization, and partial disappearance of the media. This is the first report of pathologic correlation in KD with OCT at the subacute stage, which adequately identified structural wall changes. PMID:26711918

  11. Correlation between IQIs- criteria of utilization from the level of required sensitivity

    International Nuclear Information System (INIS)

    The correct selection and utilization of the image quality indicators (IQI) is indispensable to assure the detection and allow the dimensioning of the gaps in the radiographic test. Its use by the industries lead to an inadequate use of IQI, distortioning the specifications adopted. From this observations the authors show the essentials parameters of IQIs in a way to facilitate, without quality damage or distortion of specifications, the correlation among the several types. (E.G.)

  12. Correlation between Bhalla score and spirometry in children and adolescents with Cystic Fibrosis / Correlação entre escore de Bhalla e espirometria em crianças e adolescentes com fibrose cística

    Scientific Electronic Library Online (English)

    Flavia Fajardo Linhares, Pereira; Cassio da Cunha, Ibiapina; Cristina Gonçalves, Alvim; Paulo Augusto Moreira, Camargos; Reginaldo, Figueiredo; Jesiana Ferreira, Pedrosa.

    2014-06-01

    Full Text Available Objetivo: correlacionar os achados da tomografia computadorizada de alta resolução (TCAR) do tórax, com base no escore de Bhalla, com os dados clínicos e a espirometria em crianças e adolescentes com fibrose cística (FC), além de estudar a concordância entre dois médicos radiologistas para o escor [...] e de Bhalla e suas categorias. Métodos: foram avaliados os prontuários e os exames de 23 pacientes do ambulatório. Os itens avaliados foram idade, peso, altura, escore Z altura/idade, escore Z peso/ idade, índice de massa corpórea (IMC), saturação de O2, espirometria e escore de Bhalla. Resultados: os pacientes avaliados tinham média de idade de 17,4±5,7 anos, sendo 15 do sexo feminino e 8 do sexo masculino. Houve boa correlação entre o escore de Bhalla e a espirometria (CVF-r = 0,718, p 70% já apresentavam alterações na nota final do escore de Bhalla. Na análise da concordância entre os examinadores, foi encontrado coeficiente kappa de 0,81 (p Abstract in english Objective: to correlate the findings of high resolution computed tomography of the chest based on the Bhalla score with the clinical data and spirometry in children and adolescents with cystic fibrosis, and to study the concordance between two radiologists for the Bhalla score and its categories. [...] Methods: we evaluated the medical records of 23 patients from the outpatient clinic. The items evaluated included age, weight, height, height/age Z-score, weight/age Z-score, body mass index (BMI), O2 saturation, spirometry and Bhalla score. Results: the patients had a mean age of 17.4 years ± 5.7 years, with fifteen females and eight males. There was good correlation between Bhalla score and spirometry (FVC-r =0.718, p 70% already had changes in their final Bhalla score. In the analysis of the concordance between the examiners a Kappa coefficient of 0.81 (p

  13. Correlation of proton MR spectroscopic imaging with Galena's score based on step-section pathologic analysis after radical prostatectomy

    Energy Technology Data Exchange (ETDEWEB)

    Zakian, K.L.; Sircar, K.; Hricak, H.; Chen, H.N.; Shukla-Dave, A.; Eberhardt, S.; Muruganandham, M.; Ebora, L.; Kattan, M.W.; Reuter, V.E.; Scardino, P.T.; Koutcher, J.A. [Memorial Sloan-Kettering Cancer Center, New York, NY (United States). Dept. of Medical Physics

    2005-03-15

    Purpose: To determine whether hydrogen 1 magnetic resonance (MR) spectroscopic imaging can be used to predict aggressiveness of prostate cancer. Materials and Methods: All patients gave informed consent according to an institutionally approved research protocol. A total of 123 patients (median age, 58 years; age range, 40-74 years) who underwent endorectal MR imaging and MR spectroscopic imaging between January 2000 and December 2002 were included. MR imaging and spectroscopy were performed by using combined pelvic phased-array and endorectal probe. Water and lipids were suppressed, and phase-encoded data were acquired with 6.2-mm resolution. Voxels in the peripheral zone were considered suspicious for cancer if (Cho + Cr)/Cit was at least two standard deviations above the normal level, where Cho represents choline-containing compounds, Cr represents creatine and phosphocreatine, and Cit represents citrate. Correlation between metabolite ratio and four Gleason score groups identified at step-section pathologic evaluation (3 + 3, 3 + 4, 4 + 3, and > or =4 + 4) was assessed with generalized estimating equations. Results: Data from 94 patients were included. Pathologic evaluation was used to identify 239 lesions. Overall sensitivity of MR spectroscopic imaging was 56% for tumor detection, increasing from 44% in lesions with Gleason score of 3 + 3 to 89% in lesions with Gleason score greater than or equal to 4 + 4. There was a trend toward increasing (Cho + Cr)/Cit with increasing Gleason score in lesions identified correctly with MR spectroscopic imaging. Tumor volume assessed with MR spectroscopic imaging increased with increasing Gleason score. Conclusion: MR spectroscopic imaging measurement of prostate tumor (Cho + Cr)/Cit and tumor volume correlate with pathologic Gleason score. There is overlap between MR spectroscopic imaging parameters at various Gleason score levels, which may reflect methodologic and physiologic variations. MR spectroscopic imaging has potential in noninvasive assessment of prostate cancer aggressiveness. (author)

  14. Prognostic factors for open globe injuries and correlation of Ocular Trauma Score at a tertiary referral eye care centre in Singapore

    Directory of Open Access Journals (Sweden)

    Rupesh Agrawal

    2013-01-01

    Full Text Available Objective: To evaluate the factors influencing final vision outcome after surgical repair of open globe injuries and to correlate the Ocular trauma score. Materials and Methods: Retrospective case analysis of patients with open globe injuries at a tertiary referral eye care centre in Singapore was performed. Pre-operative factors affecting final vision outcome in patients with open globe injury and correlation of ocular trauma score in our study with international ocular trauma scoring system was performed. Results: Case records of 172 eyes with open globe injury were analyzed. Mean age was 36. 67 years. Mean follow up was 12.26 m. Males were pre-dominantly affected. Initial visual acuity was ?20/40, 20/50 < 20/200, 20/200- CF, HM- PL and NLP in 24 (14%, 39 (22.7%, 16 (9.3%, 66 (38.4% and 27 (15.7% eyes respectively. Final visual acuity was ?20/40, 20/50 < 20/200, 20/200- 1/200, HM- PL and NLP in 76 (44.2%, 28 (16.3%, 11 (6.4%, 30 (17.4% and 27 (15.7% eyes respectively. Ocular trauma score in our study correlates with international ocular trauma scoring system. Conclusion: The present study showed pre-operative variables such as mode of injury, pre-operative visual acuity, traumatic cataract, hyphaema, relative afferent papillary defect, vitreous lossand vitreous hemorrhage to be adversely affecting the final vision outcome. Our study showed a good synchrony with international ocular trauma score (OTS and based on this study we were able to validate application of OTS in Singapore population. Recognizing these factors can help the surgeon in evidence based counseling.

  15. Heritabilities and genetic correlations of body condition score and muscularity with productive traits and their trend functions in Italian Simmental cattle

    OpenAIRE

    Alessandro Bagnato; Ottavia Pedron; Daniele Vicario; Antonia B. Samorè; Erika Frigo

    2013-01-01

    With the aim to study the genetics of energy and muscle balance in the Italian Simmental breed, the objectives of this study were: i) the estimation of the genetic parameters for body condition score (BCS) and muscularity (MU) score; ii) the estimation of genetic correlations of BCS and MU with productive traits; iii) the estimation of the expected pattern of BCS and MU over lactation. A total of 47,839 records of first-parity lactating cows, collected from 1999 to 2007 in 2794 herds, were us...

  16. Correlation of histological risk assessment/ scoring system with lymph node metastasis and recurrence/progression of disease in oral squamous cell carcinoma

    International Nuclear Information System (INIS)

    Objective: To correlate the scoring system using histopathologic parameters; worst pattern of invasion (WPOI), lymphocytic host response (LHR) and peri-neural invasion (PNI), with disease recurrence, overall survival and cervical lymph node metastasis in OSCC patients. Study Design: Cross sectional. Place and Duration of Study: Department of Histopathology, Shaukat Khanam Memorial Cancer and Research Hospital, Lahore in collaboration with Department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi. Study completed in 2 years. Material and Methods: A Risk Scoring system was applied to 50 cases of OSCC with 2 years follow-up data, based on histopathologic parameters WPOI, LHR and PNI. The cases were divided into High risk and Non-High risk categories according to the specified parameters and then correlated with disease recurrence, overall survival and cervical lymph node metastasis. Results: There were 7 low risk, 17 intermediate risk and 26 high risk cases. No correlation was seen between the risk groups and disease recurrence, overall survival or cervical lymph node metastasis. However, when assessing the individual parameters, significant correlation was observed between PNI with disease recurrence (p = 0.03), and between WPOI and overall survival (p = 0.02) and cervical lymph node metastasis (p = 0.005). Conclusion: The individual parameters, peri-neural invasion and worst pattern of invasion are observed to be significant prognostic indicators in OSCC patients. A study with a larger number of cases is required to truly assess the value of the scoring system in Pakistani patients. (author)

  17. Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler memory scale-revised logical/verbal memory score for healthy subjects

    International Nuclear Information System (INIS)

    Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM). T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A P value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant. Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal, T value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal, T value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found. To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing. (orig.)

  18. Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler memory scale-revised logical/verbal memory score for healthy subjects

    Energy Technology Data Exchange (ETDEWEB)

    Goto, Masami [University of Tokyo Hospital, Department of Radiological Technology, Graduate School of Medicine, Tokyo (Japan); Kanazawa University, Tsunomatyou, Graduate School of Medical Science, Kanazawa (Japan); Abe, Osamu; Takao, Hidemasa; Inano, Sachiko; Mori, Harushi; Kunimatsu, Akira; Ohtomo, Kuni [University of Tokyo Hospital, Department of Radiology, Tokyo (Japan); Miyati, Tosiaki [Kanazawa University, Tsunomatyou, Graduate School of Medical Science, Kanazawa (Japan); Yoshikawa, Takeharu; Hayashi, Naoto [University of Tokyo Hospital, Department of Computational Diagnostic Radiology and Preventive Medicine, Tokyo (Japan); Kabasawa, Hiroyuki [GE Healthcare, Japan Applied Science Laboratory, Hino (Japan); Aoki, Shigeki [Juntendo University, Department of Radiology, Tokyo (Japan); Ino, Kenji; Iida, Kyouhito; Yano, Keiichi [University of Tokyo Hospital, Department of Radiological Technology, Graduate School of Medicine, Tokyo (Japan)

    2011-08-15

    Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM). T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A P value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant. Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal, T value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal, T value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found. To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing. (orig.)

  19. Diagnostic yield of MRI for audiovestibular dysfunction using contemporary referral criteria: correlation with presenting symptoms and impact on clinical management

    Energy Technology Data Exchange (ETDEWEB)

    Vandervelde, C. [Department of Radiology, Guy' s and St Thomas' NHS Foundation Trust (United Kingdom)], E-mail: clivevandervelde@gmail.com; Connor, S.E.J. [Department of Radiology, Guy' s and St Thomas' NHS Foundation Trust (United Kingdom); Department of Neuroradiology, King' s College Hospital NHS Foundation Trust, London (United Kingdom)

    2009-02-15

    Aim: To investigate the diagnostic yield of T2-weighted magnetic resonance imaging (MRI) screening for vestibular schwannoma and other relevant conditions in the setting of audiovestibular symptoms, given the more liberal contemporary referral criteria. To determine whether presenting clinical symptoms correlate with imaging outcome in order to guide future protocols for MRI referral. Materials and methods: Eight hundred and eighty-one consecutive MRI examinations performed in patients with audiovestibular dysfunction were reviewed. Clinical indications and findings were recorded. Case notes were reviewed in patients with positive imaging findings. Two-way, cross-tabulation, Chi-square analysis was performed to assess the relationship between presenting symptoms and imaging outcome. Results: Twelve of the 881 (1.4%) were positive for vestibular schwannoma. A further four of 881 (0.4%) revealed other relevant conditions. Incidental conditions, felt to be irrelevant to the presenting symptoms, were noted in 12 of the 881 (1.4%). In all 12 cases that were positive for vestibular schwannoma, either tinnitus or hearing loss was present. Conclusion: The yield for T2-weighted MRI to diagnose vestibular schwannoma and other relevant retrocochlear conditions was lower than for previous studies, which is likely to reflect trends in referral criteria. No single audiovestibular symptom or combination of symptoms is a statistically significant predictor of imaging outcome.

  20. Diagnostic yield of MRI for audiovestibular dysfunction using contemporary referral criteria: correlation with presenting symptoms and impact on clinical management

    International Nuclear Information System (INIS)

    Aim: To investigate the diagnostic yield of T2-weighted magnetic resonance imaging (MRI) screening for vestibular schwannoma and other relevant conditions in the setting of audiovestibular symptoms, given the more liberal contemporary referral criteria. To determine whether presenting clinical symptoms correlate with imaging outcome in order to guide future protocols for MRI referral. Materials and methods: Eight hundred and eighty-one consecutive MRI examinations performed in patients with audiovestibular dysfunction were reviewed. Clinical indications and findings were recorded. Case notes were reviewed in patients with positive imaging findings. Two-way, cross-tabulation, Chi-square analysis was performed to assess the relationship between presenting symptoms and imaging outcome. Results: Twelve of the 881 (1.4%) were positive for vestibular schwannoma. A further four of 881 (0.4%) revealed other relevant conditions. Incidental conditions, felt to be irrelevant to the presenting symptoms, were noted in 12 of the 881 (1.4%). In all 12 cases that were positive for vestibular schwannoma, either tinnitus or hearing loss was present. Conclusion: The yield for T2-weighted MRI to diagnose vestibular schwannoma and other relevant retrocochlear conditions was lower than for previous studies, which is likely to reflect trends in referral criteria. No single audiovestibular symptom or combination of symptoms is a statistically significant predictor of imaging outcome

  1. Correlation of regional distribution and morphological pattern of calcification at CT coronary artery calcium scoring with non-calcified plaque formation and stenosis

    International Nuclear Information System (INIS)

    To investigate whether regional calcification patterns at CT coronary artery calcium scoring (CCS) correlate with stenosis and non-calcified plaque formation. We studied 106 patients with quantitative catheter angiography (QCA), CCS, and coronary CT angiography (cCTA). CCS was determined globally and for each artery separately. The morphological pattern of each calcification was classified as calcified nodule, shell-like, or diffuse. cCTA studies were evaluated for non-calcified plaque. The global and regional CCS and the calcification pattern were correlated with stenosis ?50% and non-calcified plaque. A total of 48/106 patients had stenosis ?50% on QCA. There was weak correlation (r = 0.36) of the global CCS with stenosis. Correlation was stronger per vessel (r = 0.55-r = 0.67). Shell-like and diffuse calcifications were significantly (p = 0.0001) more frequently associated with ?50% stenosis and non-calcified plaque (p = 0.04) than calcified nodules. As shown before, the global CCS does not correlate well with stenosis. However, regional calcium distribution and specific patterns of calcification are correlated with stenosis and non-calcified plaque. Thus, the specificity of CT calcium scoring for identifying individuals with obstructive disease could be improved by vessel-based rather than global quantification of calcium and by differentiating specific morphological patterns of calcification. (orig.)

  2. Correlation of histopathologic features of ductal carcinoma in situ of the breast with the oncotype DX DCIS score.

    Science.gov (United States)

    Knopfelmacher, Adriana; Fox, Jana; Lo, Yungtai; Shapiro, Nella; Fineberg, Susan

    2015-09-01

    The Oncotype DX Breast Cancer Assay for ductal carcinoma in situ is used to determine local recurrence risk in patients with ductal carcinoma in situ. The results help select patients with low-risk ductal carcinoma in situ who could forgo radiation therapy after conservative surgery. The genes assessed include five proliferation genes, progesterone receptor (PR), and GSTM-1. Our objective was to determine if PR, mitotic counting, or any other pathologic feature of ductal carcinoma in situ could predict the Oncotype DX DCIS Score. We identified 46 cases of ductal carcinoma in situ with a Oncotype DX DCIS Score. In addition to information obtained from routine pathology, we counted mitotic figures in the ductal carcinoma in situ and noted presence of dense chronic inflammatory infiltrate surrounding ductal carcinoma in situ. We found that PR ? 90% (P = 0.004), mitotic count ? 1 (P = 0.045), estrogen receptor ? 90% (P = 0.046), and low nuclear grade (P figure and absence of dense chronic inflammation around ductal carcinoma in situ had a low score (100% specificity). A low score was not observed in any case with at least two of the following--negative PR, >1 mitotic figure, and/or presence of dense chronic inflammation around ductal carcinoma in situ (100% specificity). Our study suggests using a combination of PR (? 90% vs negative) with mitotic count in ductal carcinoma in situ (? 1 vs >1) and dense chronic inflammation around ductal carcinoma in situ one could predict the Oncotype DX DCIS score. Mitotic counting and evaluation of immune response might provide prognostic information in ductal carcinoma in situ. PMID:26111975

  3. Correlations of plasma and urinary phenylacetic acid and phenylethylamine concentrations with eating behavior and mood rating scores in brofaromine-treated women with bulimia nervosa.

    OpenAIRE

    Davis, B A; Kennedy, S. H.; D'Souza, J; Durden, D A; Goldbloom, D. S.; Boulton, A. A.

    1994-01-01

    Women with bulimia nervosa undergoing treatment with the reversible monoamine oxidase type A inhibitor, brofaromine, were rated for mood and eating behaviour and their plasma and urine were assessed for phenylacetic acid (unconjugated and total) and unconjugated phenylethylamine prior to and after four weeks of drug treatment. Changes in plasma unconjugated phenylacetic acid concentrations were significantly and negatively correlated with the corresponding changes in Hamilton Depression score...

  4. CORRELATION BETWEEN ANTHROPOMETRY, BIOCHEMICAL MARKERS AND SUBJECTIVE GLOBAL ASSESSMENT – DIALYSIS MALNUTRITION SCORE AS PREDICTORS OF NUTRITIONAL STATUS OF THE MAINTENANCE HEMODIALYSIS PATIENTS

    OpenAIRE

    Vanitha Rani N, S. Kavimani, Soundararajan P, Chamundeeswari D, Kannan Gopal

    2015-01-01

    Background: Protein energy malnutrition is the major cause of poor prognostic outcome in patients on maintenance hemodialysis (MHD). The assessment of nutritional status in patients on maintenance hemodialysis should be done both subjectively and objectively by integrating clinical, biochemical and anthropometric measurements. A study was conducted to assess the possible correlations between the subjective global assessment-dialysis malnutrition score (SGA-DMS), anthropometric measurements, a...

  5. Does Council Tax Valuation Band (CTVB correlate with Under-Privileged Area 8 (UPA8 score and could it be a better 'Jarman Index'?

    Directory of Open Access Journals (Sweden)

    Taylor Gordon

    2001-11-01

    Full Text Available Abstract Background Widespread scepticism persists on the use of the Under-Privileged Area (UPA8 score of Jarman in distributing supplementary resources to so-attributed 'deprived' UK general practices. The search for better 'needs' markers continues. Having already shown that Council Tax Valuation Band (CTVB is a predictor of UK GP workload, we compare, here, CTVB of residence of a random sample of patients with their respective 'Jarman' scores. Methods Correlation coefficient is calculated between (i the CTVB of residence of a randomised sample of patients from an English general practice and (ii the UPA8 scores of the relevant enumeration districts in which they live. Results There is a highly significant correlation between the two measures despite modest study size of 478 patients (85% response. Conclusions The proposal that CTVB is a marker of deprivation and of clinical demand should be examined in more detail: it correlates with 'Jarman', which is already used in NHS resource allocation. But unlike 'Jarman', CTVB is simple, objective, and free of the problems of Census data. CTVB, being household-based, can be aggregated at will.

  6. Segmented corpus callosum diffusivity correlates with the Expanded Disability Status Scale score in the early stages of relapsing-remitting multiple sclerosis

    Scientific Electronic Library Online (English)

    Carolina de Medeiros, Rimkus; Thiago de Faria, Junqueira; Dagoberto, Callegaro; Maria Concepcion Garcia, Otaduy; Claudia da Costa, Leite.

    Full Text Available OBJECTIVE: The aim of this study was to characterize the microscopic damage to the corpus callosum in relapsing-remitting multiple sclerosis (RRMS) with diffusion tensor imaging and to investigate the correlation of this damage with disability. The diffusion tensor imaging parameters of fractional [...] anisotropy and mean diffusivity provide information about the integrity of cell membranes, offering two more specific indices, namely the axial and radial diffusivities, which are useful for discriminating axon loss from demyelination. METHOD: Brain magnetic resonance imaging exams of 30 relapsing-remitting multiple sclerosis patients and 30 age- and sex-matched healthy controls were acquired in a 3T scanner. The axial diffusivities, radial diffusivities, fractional anisotropy, and mean diffusivity of five segments of the corpus callosum, correlated to the Expanded Disability Status Scale score, were obtained. RESULTS: All corpus callosum segments showed increased radial diffusivities and mean diffusivity, as well as decreased fractional anisotropy, in the relapsing-remitting multiple sclerosis group. The axial diffusivity was increased in the posterior midbody and splenium. The Expanded Disability Status Scale scores correlated more strongly with axial diffusivities and mean diffusivity, with an isolated correlation with radial diffusivities in the posterior midbody of the corpus callosum. There was no significant correlation with lesion loads. CONCLUSION: Neurological dysfunction in relapsing-remitting multiple sclerosis can be influenced by commissural disconnection, and the diffusion indices of diffusion tensor imaging are potential biomarkers of disability that can be assessed during follow-up.

  7. Correlation between clinical clerkship achievement and objective structured clinical examination (OSCE) scores of graduating dental students on conservative dentistry

    OpenAIRE

    Bang, Jae-Beum; Choi, Kyoung-Kyu

    2013-01-01

    Objectives This study aimed to investigate the effect of clinical clerkship-associated achievements, such as performance of procedures at the student clinic, observation, and attitude towards a clerkship, on the objective structured clinical examination (OSCE) scores of dental students graduating in restorative dentistry. Materials and Methods The OSCEs consisted of two stations designed to assess students' clinical skills regarding cavity preparation for a class II gold inlay and a class IV ...

  8. Genetic Risk Score Does Not Correlate with Body Mass Index of Latina Women in a Clinical Trial

    OpenAIRE

    Coenen, Kimberly R.; Karp, Sharon M.; Gesell, Sabina B.; Dietrich, Mary S; Morgan, Thomas M; Barkin, Shari L.

    2011-01-01

    Obesity disproportionately affects Latina women. Common genetic variants are convincingly associated with BMI and may be used to create genetic risk scores (GRS) for obesity that could define genetically influenced forms of obesity and alter response to clinical trial interventions. The objective of this study was: 1) to identify the frequency and effect size of common obesity genetic variants in Latina women; 2) to determine the clinical utility of a GRS for obesity with Latina women partici...

  9. Genetic Risk Score of NOS Gene Variants Associated with Myocardial Infarction Correlates with Coronary Incidence across Europe

    OpenAIRE

    Carreras-Torres, Robert; Kundu, Suman; Zanetti, Daniela; Esteban, Tapella; Via, Marc; Moral, Pedro

    2014-01-01

    Coronary artery disease (CAD) mortality and morbidity is present in the European continent in a four-fold gradient across populations, from the South (Spain and France) with the lowest CAD mortality, towards the North (Finland and UK). This observed gradient has not been fully explained by classical or single genetic risk factors, resulting in some cases in the so called Southern European or Mediterranean paradox. Here we approached population genetic risk estimates using genetic risk scores ...

  10. Correlações genéticas entre escores visuais e características reprodutivas em bovinos Nelore usando inferência bayesiana / Genetic correlations between visual scores and reproductive traits in Nelore cattle using Bayesian inference

    Scientific Electronic Library Online (English)

    Arione Augusti, Boligon; Lucia Galvão de, Albuquerque.

    2010-12-01

    Full Text Available O objetivo deste trabalho foi estimar a herdabilidade e as correlações genéticas entre escores visuais e características reprodutivas de animais da raça Nelore. As características avaliadas foram: precocidade, musculatura, e escores de conformação à desmama (PD, MD e CD, respectivamente) e ao sobrea [...] no (PS, MS e CS, respectivamente); idade ao primeiro parto (IPP); e perímetro escrotal (PE). Foram utilizadas informações de 66.244 animais, nascidos entre 1990 e 2006. Os parâmetros genéticos foram estimados em análises bicaracterísticas, com inferência bayesiana. Foi utilizado um modelo linear para IPP e PE, e um modelo não linear ("threshold") para os escores visuais. As herdabilidades estimadas foram: CD, 0,19±0,02; PD, 0,23±0,02; MD, 0,20±0,02; CS, 0,26±0,01; PS, 0,33±0,02; MS, 0,32±0,02; IPP, 0,16±0,03; e PE, 0,36±0,02. As correlações genéticas estimadas entre os escores visuais e IPP foram negativas, de -0,18±0,03 a -0,29±0,02. Correlações genéticas positivas foram obtidas entre os escores visuais e o PE, de 0,19±0,01 a 0,31±0,01. A seleção de animais com os maiores escores visuais, principalmente ao sobreano, permite melhorar o desempenho reprodutivo dos rebanhos Abstract in english The aim of this work was to estimate the heritability and the genetic correlations between visual scores and reproductive traits of Nelore cattle. The traits evaluated were: finishing, muscling, and conformation scores at weaning (PD, MD, and CD, respectively) and yearling (PS, MS and CS, respective [...] ly); age at the first calving (IPP) and scrotal circumference (PE). The records of 66,244 animals born between 1990 and 2006 were used. The genetic parameters were estimated using bi-trait animal analyses with Bayesian inference. A linear model for IPP and PE and a nonlinear (threshold) model for visual scores were used. The heritability estimates were: CD, 0.19±0.02; PD, 0.23±0.02; MD, 0.20±0.02; CS, 0.26±0.01; PS, 0.33±0.02; MS, 0.32±0.02; IPP, 0.16±0.03; and PE, 0.36±0.02. Genetic correlation estimates between visual scores and IPP were negative, varying from -0.18±0.03 to -0.29±0.02. Positive genetic correlations were obtained between the visual scores and PE, from 0.19±0.01 to 0.31±0.01. Animal selection with the highest visual scores, mainly those taken after the yearling age, allows to improve herd reproductive traits

  11. Vacuolization, Dilatation, Hyaline Cast, Debris or Degeneration: Which One Is the Most Correlated Item to Score the Kidney Damage Pathologically in Cisplatin Induced Nephrotoxicity Model?

    Science.gov (United States)

    Ashrafi, Farzaneh; Nematbakhsh, Mehdi; Nasri, Hamid; Talebi, Ardeshir; Hosseini, Sayed Mohsen; Ashrafi, Mehdi

    2013-01-01

    Background Nephrotoxicity is characterized and scored by many parameters such as vacuolization, dilatation, hyaline cast, debris or degeneration in injured renal tissue. In this short report, we attempt to find, the most correlated parameters with kidney tissue pathology damage score (PDS) in Cisplatin-induced nephrotoxicity. Method A total of 207 normal and toxic rats’ kidney tissue (induced by Cisplatin) were evaluated for toxicity intensity by two methods. In the first method, the tissue damage was scored from 0 to 4, and in the second method the percentage of vacuolization, dilatation, hyaline cast, debris or degeneration were determined. The data was analyzed using stepwise discriminant function and regression analysis. Results The variables having the higher discriminant function coefficient were hyaline cast, dilatation, and degeneration. The linear regression model and the prediction function to determine the kidney tissue PDS were generated as below. PDS = 0.445 + 0.035 × hyaline cast + 0.013 × dilatation + 0.020 × degeneration Conclusion According to this finding it is suggested that presence of hyaline cast and dilatation, and then degeneration in the sample of toxic renal tissue are the most important item to score the damage intensity. PMID:24350092

  12. Correlation between Dermatology Life Quality Index (DLQI) scores and Work Limitations Questionnaire (WLQ) allows the calculation of percent work productivity loss in patients with psoriasis.

    Science.gov (United States)

    Schmitt, Jochen; Küster, Denise

    2015-07-01

    Data on indirect costs are vital for cost-effectiveness studies from a societal perspective. In contrast to quality of life, information on productivity loss is rarely collected in psoriasis trials. We aimed to identify a model to deduce indirect costs (presenteeism and absenteeism) of psoriasis from the Dermatologic Life Quality Index (DLQI) of affected patients to facilitate health economic evaluations for psoriasis. We undertook a cross-sectional mapping study including 201 patients with physician-diagnosed psoriasis and investigated the relationship between quality of life (DLQI) and productivity loss (Work Limitations Questionnaire, WLQ--using the "output demands" subscale) using linear bootstrap regression analysis to set up an equation model allowing the calculation of percent work productivity loss per DLQI unit increase. DLQI and WLQ scores were significantly correlated (r = 0.47; p presenteeism and absenteeism per DLQI unit increase, with y-intercepts at 1.654 and 0.536, respectively. In the absence of data on indirect cost, work productivity loss due to psoriasis can be estimated from DLQI scores using the equations, Y = 0.545 × DLQI score + 1.654 for presenteeism (%) and Y = 0.560 × DLQI score + 0.536 for absenteeism (%). PMID:25940274

  13. Insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in prostate cancer and correlates with higher Gleason scores

    International Nuclear Information System (INIS)

    The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA) organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC). IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p < 0.0001), but did not show significant correlation with the pT-stage, the proliferation index (MIB1), preoperative serum PSA level and the margin status. Only a weak and slightly significant correlation was found with the Gleason score and IMP3 expression failed to show prognostic significance in clinico-pathological correlation-analyses. Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed

  14. Cervical lymph node metastasis: correlative study of CT, ultrasound and pathology. Pt. 1. Criteria for evaluating cervical lymph node metastasis

    International Nuclear Information System (INIS)

    Purpose: To evaluate the criteria of CT, ultrasonography and combination of the two in the diagnosis of cervical lymph node metastases. Materials and methods: Sixty patients were prospectively studied by CT and ultrasonography prior to cervical lymph node dissection, and correlated with pathologic specimens. The results were studied in double-blind way. Results: The minimal nodal diameter?8 mm as the diagnosis threshold was used for deep jugular chain nodes for CT or US, the sensitivity was 91.67%, 83.33% and specificity was 98.61% and 97.22% respectively. For level VII (nodes located in tracheoesophageal groove), minimal diameter?5 mm was used as diagnostic threshold of CT, the sensitivity was 69.23%, specificity was 100%. With contrast enhanced CT, nodes with enhancing rim and central low attenuation were shown in 44 nodal regions, all were proved pathologically as metastases (specificity, 100%). Conclusion: Using contrast enhanced CT as the basic imaging modality, the minimal diameter?8 mm can be used as the criterion of size of metastasis in deep jugular chain (level II?IV) nodes. For the tracheoesophageal groove node (level VII), minimal diameter?5 mm is more acceptable. Enhancing rim with central low attenuation is a reliable sign for diagnosing cervical lymph node metastases, in patients with known primary cancer

  15. Correlation of Preoperative Renal Insufficiency With Mortality and Morbidity After Aortic Valve Replacement: A Propensity Score Matching Analysis.

    Science.gov (United States)

    Lin, Chun-Yu; Tsai, Feng-Chun; Chen, Yung-Chang; Lee, Hsiu-An; Chen, Shao-Wei; Liu, Kuo-Sheng; Lin, Pyng-Jing

    2016-03-01

    Preoperative end-stage renal disease carries a high mortality and morbidity risk after aortic valve replacement (AVR), but the effect of renal insufficiency remains to be clarified. Through propensity score analysis, we compared the preoperative demographics, perioperative profiles, and outcomes between patients with and without renal insufficiency.From August 2005 to November 2014, 770 adult patients underwent AVR in a single institution. Patients were classified according to their estimated glomerular infiltration rate (eGFR) as renal insufficiency (eGFR: 30-89?mL/min/1.73?m) or normal (eGFR, ?90?mL/min/1.73?m). Propensity scoring was performed with a 1:1 ratio, resulting in a matched cohort of 88 patients per group.Demographics, comorbidities, and surgical procedures were well balanced between the 2 groups, except for diabetes mellitus and eGFR. Patients with renal insufficiency had higher in-hospital mortality (19.3% versus 3.4%, P?72 hour; 25% versus 9.1%, P?=?.008), intensive care unit stays (8.9?±?9.9 versus 4.9?±?7.5 days, P?=?.046), and hospital stays (35.3?±?31.7 versus 24.1?±?20.3 days, P?=?.008), compared with those with normal renal function. Multivariate analysis confirmed that preoperative renal insufficiency was an in-hospital mortality predictor (odds ratio, 2.33; 95% confidence interval, 1.343-4.043; P?=?.003), as were prolonged cardiopulmonary bypass time, intraaortic balloon pump support, and postoperative hemodialysis. The 1-year survival significantly differed between the 2 groups including (normal 87.5% versus renal insufficiency 67.9%, P?AVR had higher in-hospital mortality rates and increased morbidities, especially those associated with hemodynamic instabilities requiring intraaortic balloon pump support or hemodialysis. Earlier surgical intervention for severe aortic valve disease should be considered in patients who show deteriorating renal function during follow-up. PMID:26945348

  16. Pre-Transplant CDKN2A Expression in Kidney Biopsies Predicts Renal Function and Is a Future Component of Donor Scoring Criteria

    Science.gov (United States)

    Gingell-Littlejohn, Marc; McGuinness, Dagmara; McGlynn, Liane M.; Kingsmore, David; Stevenson, Karen S.; Koppelstaetter, Christian; Clancy, Marc J.; Shiels, Paul G.

    2013-01-01

    CDKN2A is a proven and validated biomarker of ageing which acts as an off switch for cell proliferation. We have demonstrated previously that CDKN2A is the most robust and the strongest pre-transplant predictor of post- transplant serum creatinine when compared to “Gold Standard” clinical factors, such as cold ischaemic time and donor chronological age. This report shows that CDKN2A is better than telomere length, the most celebrated biomarker of ageing, as a predictor of post-transplant renal function. It also shows that CDKN2A is as strong a determinant of post-transplant organ function when compared to extended criteria (ECD) kidneys. A multivariate analysis model was able to predict up to 27.1% of eGFR at one year post-transplant (p?=?0.008). Significantly, CDKN2A was also able to strongly predict delayed graft function. A pre-transplant donor risk classification system based on CDKN2A and ECD criteria is shown to be feasible and commendable for implementation in the near future. PMID:23861858

  17. Criteria of GenCall score to edit marker data and methods to handle missing markers have an influence on accuracy of genomic predictions

    DEFF Research Database (Denmark)

    Edriss, Vahid; Guldbrandtsen, Bernt

    2013-01-01

    The aim of this study was to investigate the effect of different strategies for handling low-quality or missing data on prediction accuracy for direct genomic values of protein yield, mastitis and fertility using a Bayesian variable model and a GBLUP model in the Danish Jersey population. The data contained 1071 Jersey bulls that were genotyped with the Illumina Bovine 50K chip. After preliminary editing, 39227 SNP remained in the dataset. Four methods to handle missing genotypes were: 1) BEAGLE: missing markers were imputed using Beagle 3.3 software, 2) COMMON: missing genotypes at a locus were replaced by the most common genotype at this locus observed in the marker data, 3) EX-ALLELE: missing marker genotypes at a locus were treated as an extra allele, and 4) POP-EXP: missing genotypes at a locus were replaced with population expectation at this locus. It was shown that among the methods used in this study, imputation with Beagle was the best approach to handle missing genotypes. Treating missing markers as a pseudo-allele, replacing missing markers with a population average or substituting the most common alleles each reduced the accuracy of genomic predictions. The results from this study suggest that missing genotypes should be imputed in order to improve genomic prediction. Editing the marker data with stringent threshold on GenCall (GC) scores and then imputing the discarded genotypes did not lead to higher accuracy. All marker genotypes with a GC score over 0.15 should be retained for genomic prediction

  18. Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic (type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease

    Science.gov (United States)

    Puchakayala, Bharat K; Verma, Siddharth; Kanwar, Pushpjeet; Hart, John; Sanivarapu, Raghavendra R; Mohanty, Smruti R

    2015-01-01

    AIM: To study clinical and histopathological features of nonalcoholic fatty liver disease (NAFLD) in patients with and without type 2 diabetes mellitus (T2DM) using updated nonalcoholic steatohepatitis clinical research network (NASH-CRN) grading system. METHODS: We retrospectively analyzed data of 235 patients with biopsy proven NAFLD with and without T2DM. This database was utilized in the previously published study comparing ethnicity outcomes in NAFLD by the same corresponding author. The pathology database from University of Chicago was utilized for enrolling consecutive patients who met the criteria for NAFLD and their detailed clinical and histopathology findings were obtained for comparison. The relevant clinical profile of patients was collected from the Electronic Medical Records around the time of liver biopsy and the histology was read by a single well-trained histopathologist. The updated criteria for type 2 diabetes have been utilized for analysis. Background data of patients with NASH and NAFLD has been included. The mean differences were compared using ?2 and t-test along with regression analysis to evaluate the predictors of NASH and advanced fibrosis. RESULTS: Patients with NAFLD and T2DM were significantly older (49.9 vs 43.0, P high-density lipoprotein cholesterol level (42.7 vs 48.1, P = 0.01) was lower among patients with NASH compared to patients with steatosis. CONCLUSION: Patients with NAFLD and T2DM tend to have more advanced stages of NAFLD, particularly advanced fibrosis and higher rate of ballooning than patients with NAFLD without T2DM.

  19. Incidence of BCR-ABL transcript variants in patients with chronic myeloid leukemia: Their correlation with presenting features, risk scores and response to treatment with imatinib mesylate

    Directory of Open Access Journals (Sweden)

    Pratik Deb

    2014-01-01

    Full Text Available Context: The exact role of the different transcript variants of BCR-ABL in the pathogenesis of chronic myeloid leukemia (CML and their impact on prognosis is yet to be definitely enumerated. Aims: In this study, we have tried to correlate the presenting features, risk scores and treatment response with the BCR-ABL variants detected in our patients. Settings and Design: A cross-sectional unicentric hospital-based study on 80 patients diagnosed to have CML by bone marrow cytogenetics and confirmed by reverse transcriptase-polymerase chain reaction (RT-PCR. Materials and Methods: RT-PCR for BCR-ABL was performed on consecutive patients with CML attending the CML clinic from January 2010 to December 2010.The medical charts of these patients were analyzed after a follow-up of 18 months in a retrospective manner. Statistical Analysis: Box plot and histogram was used to see the distribution of variables. t-test was performed to enumerate the difference between risk scores in two populations of patients carrying two different BCR-ABL transcript variants. Results: Nearly 56.25% of patients had b3a2 (e14a2 while 41.25% of patients showed b2a2 (e13a2 transcripts. The rest 2.5% (two patients expressed the rare e19b2 variant. Patients with b2a2 presented with higher Sokal, Hasford and European Treatment and Outcomes Study score than their b3a2 counterpart. Different parameters such as the platelet count, leukocyte count, hemoglobin and splenomegaly showed a minor difference between the groups. More patients in the b2a2 group achieved complete hematologic response at 3 months, but it was not significant. Conclusions: Patients with b2a2 variant CML tend to present with higher risk score, but do not behave in a vastly different manner than their b3a2 counterparts.

  20. Correlations between the scores of computerized adaptive testing, paper and pencil tests, and the Korean Medical Licensing Examination

    Directory of Open Access Journals (Sweden)

    Mee Young Kim

    2005-06-01

    Full Text Available To evaluate the usefulness of computerized adaptive testing (CAT in medical school, the General Examination for senior medical students was administered as a paper and pencil test (P&P and using CAT. The General Examination is a graduate examination, which is also a preliminary examination for the Korean Medical Licensing Examination (KMLE. The correlations between the results of the CAT and P&P and KMLE were analyzed. The correlation between the CAT and P&P was 0.8013 (p=0.000; that between the CAT and P&P was 0.7861 (p=0.000; and that between the CAT and KMLE was 0.6436 (p=0.000. Six out of 12 students with an ability estimate below 0.52 failed the KMLE. The results showed that CAT could replace P&P in medical school. The ability of CAT to predict whether students would pass the KMLE was 0.5 when the criterion of the theta value was set at -0.52 that was chosen arbitrarily for the prediction of pass or failure.

  1. The Effect of Examiner Variation in Cartridge Case Acquisition on IBISreg Correlation Scores and the Ability of the System to Return a True Positive

    Science.gov (United States)

    Scicchitano, Kristine M.

    When entering cartridge case exhibits into the Integrated Ballistics Identification System (IBISRTM), examiners have the ability to manually manipulate three parameters: lighting intensity, ring selection and exhibit orientation. User guidelines for these settings are subjective, and the effect of examiner variation is largely unknown. If examiner variation negatively affects the returned correlation scores, the ability of the system to return true positives will be compromised. By entering cartridge cases into IBISRTM 88 separate times, using 88 different combinations of parameter settings, the effect of these variables was determined. Analysis of variance testing revealed that no variable has a statistically significant effect on average true positive combined correlation scores or results list position. This did not change when the parameters were tested individually or in combination. Results indicate that examiner variability of cartridge case image acquisition has no effect on the outcome of IBIS RTM. The system's matching algorithm is robust enough to handle exhibit entry and data collection without the intervention of human input. For this reason, acquisition could be completely automated, allowing examiners to focus on the decision making stage of cartridge case comparison.

  2. CORRELATION BETWEEN ANTHROPOMETRY, BIOCHEMICAL MARKERS AND SUBJECTIVE GLOBAL ASSESSMENT – DIALYSIS MALNUTRITION SCORE AS PREDICTORS OF NUTRITIONAL STATUS OF THE MAINTENANCE HEMODIALYSIS PATIENTS

    Directory of Open Access Journals (Sweden)

    Vanitha Rani N, S. Kavimani, Soundararajan P, Chamundeeswari D, Kannan Gopal

    2015-10-01

    Full Text Available Background: Protein energy malnutrition is the major cause of poor prognostic outcome in patients on maintenance hemodialysis (MHD. The assessment of nutritional status in patients on maintenance hemodialysis should be done both subjectively and objectively by integrating clinical, biochemical and anthropometric measurements. A study was conducted to assess the possible correlations between the subjective global assessment-dialysis malnutrition score (SGA-DMS, anthropometric measurements, and biochemical parameters in hemodialysis patients. Methods: The study included 90 patients (55 males and 35 females; age range of 25 to 73 years; mean age 52.62 ± 11.7 years undergoing twice/thrice weekly maintenance hemodialysis for six months and above in the dialysis unit of a tertiary care teaching hospital. The MHD patients were assessed by SGA -DMS, anthropometry and biochemical indicators (serum albumin, iron, ferritin and transferrin of nutritional status. Results: According to the SGA-DMS 54.4 % were moderate to severely malnourished, 31% were mild to moderately nourished and 14.4% were well nourished. There was a highly significant negative correlation between SGA –DMS and serum albumin, iron, transferrin; positive correlation between SGA-DMS and ferritin (P<0.0001. Body mass index, upper arm circumferences, and skin fold thickness had a highly significant negative correlation with SGA-DMS (P<0.001, where as the lean body mass, total body water and the fat free mass had a significant negative correlation (P<0.05. Conclusion: SGA-DMS correlated with anthropometric and biochemical parameters that are indicative of nutritional status. SGA –DMS used in conjunction with other objective nutritional assessment methods may be of greater impact in determining nutritional status of hemodialysis patients.

  3. Assessment of the metabolic flow phenotype of primary colorectal cancer: correlations with microvessel density are influenced by the histological scoring method

    Energy Technology Data Exchange (ETDEWEB)

    Goh, Vicky [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Rodriguez-Justo, Manuel [University College Hospital, Department of Histopathology, London (United Kingdom); Engledow, Alec; Peck, Jacqui [University College Hospital, Department of Surgery, London (United Kingdom); Shastry, Manu; Endozo, Raymondo; Meagher, Marie; Groves, Ashley M. [University College Hospital, Institute of Nuclear Medicine, London (United Kingdom); Taylor, Stuart A.; Halligan, Steve [University College Hospital, Specialist Radiology, London (United Kingdom)

    2012-08-15

    To investigate how the histological scoring of microvessel density affects correlations between integrated {sup 18}F-FDG-PET/perfusion CT parameters and CD105 microvessel density. A total of 53 patients were enrolled from 2007 to 2010. Integrated {sup 18}F-FDG-PET/perfusion CT was successful in 45 patients, 35 of whom underwent surgery without intervening treatment. Tumour SUV{sub max}, SUV{sub mean} and regional blood flow (BF) were derived. Immunohistochemical staining for CD105 expression and analysis were performed for two hot spots, four hot spots and the Chalkley method. Correlations between metabolic flow parameters and CD105 expression were assessed using Spearman's rank correlation. Mean (SD) for tumour size was 38.5 (20.5) mm, for SUV{sub max}, SUV{sub mean} and BF it was 19.1 (4.5), 11.6 (2.5) and 85.4 (40.3) mL/min/100 g tissue, and for CD105 microvessel density it was 71.4 (23.6), 66.8 (22.9) and 6.18 (2.07) for two hot spots, four hot spots and the Chalkley method, respectively. Positive correlation between BF and CD105 expression was modest but higher for Chalkley than for four hot spots analysis (r = 0.38, P = 0.03; r = 0.33, P = 0.05, respectively). There were no significant correlations between metabolic parameters (SUV{sub max} or SUV{sub mean}) and CD105 expression (r = 0.08-0.22, P = 0.21-0.63). The histological analysis method affects correlations between tumour CD105 expression and BF but not SUV{sub max} or SUV{sub mean}. (orig.)

  4. INVESTIGATING THE CORRELATION BETWEEN ACADEMIC AVARAGES OF ELEMENTARY ENGLISH COURSE AND ENGLISH SUB-TEST SCORES IN LEVEL DETERMINATION EXAMINATION WITH STRUCTURAL EQUATION MODELLING

    Directory of Open Access Journals (Sweden)

    Gökhan BA?

    2013-06-01

    Full Text Available Purpose and Significance: The central examinations have been per¬formed with the aim of selecting and placing the students in the various education institutions for a long time in Turkey. Among these central examinations come the ones that are performed in the transition from elementary education to secondary education first (Karakaya, 2012. In the transition from elementary education to sec¬ondary education, the results of the Level Determination Examination, known as SBS are used. In order to select students and place them in second¬ary schools, the Level Determination Examination (LDE has been performed for the 6th, 7th, and 8th grades since the academic year 2007–2008 (MEB, 2010a. The Level Determination Examination includes five sub-tests, which are Turkish, mathematics, science and technology, social sciences, and foreign languages (MEB, 2010b. After the elementary curriculum has been renewed in 2005-2006 academic year, alternative measurement and assessment approaches are being used in the classrooms such as project work, classroom involvement, performance work, portfolio, etc. (At?lgan, Kan & Do?an, 2011. Amongst these, project work, classroom involvement, performance work, and formal examinations at school are being used for the transition from elementary education to sec¬ondary education as well as the result of the Level Determination Examination (MEB, 2010a. When the related literature is viewed, it is seen that there are many studies on the effects of the LDE (Sevindik, 2009; Üzkurt & Koçako?lu, 2009; An?l et al., 2010; Güler, 2010; Erdo?an, Giorgietti & Çifçili, 2010; Kelecio?lu, Atalay & Öztürk, 2010; Kurt, 2010; Y?lmaz, 2010; An?l & Güzeller, 2011; Bal, 2011; ?ahin, 2011; Güzeller, 2012; Karakaya, 2012; Karakaya & Kutlu, 2012. These studies are seen that they have mostly focused on mathematics and science and technology sub-tests in the LDE. However, it is understood that there are no studies which focuses on other sub-tests of the LDE such as Turkish, social sciences, and foreign languages. Therefore, more studies are needed in order to investigate factors affecting students’ performance in the LDE. Hence, it is thought to be important to analyze the relationship between the means of the academic achievement scores of the students in English course that they had from different means of measurement and the raw scores of LDT English sub-test. In this regard, the purpose of this study is to investigate the correlation between academic averages of elementary English course and English sub-test scores in the Level Determination Examination (LDE with structural equation modelling. Method: The correlative investigation model was used in the research (McMillan & Schumacher, 2006. This model is one of the most commonly applied models in the related literature (Cohen, Manion & Morrison, 2003. A struc¬tural equation model was formed in order to better illustrate the correlation between variables in the research (Brown, 2006. Structural equation model connects the predictive structural correlations holding between the variables in the regression model to the covered factor structures in the factor analysis through a comprehensive analysis (Sümer, 2000. The population of this study consisted of students in elementary schools within the borders of Nigde province of Turkey. In order to detect the sampling of the study, from elementary schools in cosmos, 375 students from six public elementary schools were chosen according to random sampling method (Karasar, 2005. In this research, LISREL 8.51 structural equation programme was used in model establishing by using the observed variables predicted. Discussion: It was found a linear positive significant high correlation between written exams variable to academic scores in relation to the Level Determination Examination English sub-test in the research. Verim (2006 and Güzeller (2012 found similar findings to the related finding of this study. Also, Sevindik (2009 and Üzkurt and Koçako?lu (2009 found similar findings which

  5. Real external predictivity of QSAR models: how to evaluate it? Comparison of different validation criteria and proposal of using the concordance correlation coefficient.

    Science.gov (United States)

    Chirico, Nicola; Gramatica, Paola

    2011-09-26

    The main utility of QSAR models is their ability to predict activities/properties for new chemicals, and this external prediction ability is evaluated by means of various validation criteria. As a measure for such evaluation the OECD guidelines have proposed the predictive squared correlation coefficient Q(2)(F1) (Shi et al.). However, other validation criteria have been proposed by other authors: the Golbraikh-Tropsha method, r(2)(m) (Roy), Q(2)(F2) (Schu?u?rmann et al.), Q(2)(F3) (Consonni et al.). In QSAR studies these measures are usually in accordance, though this is not always the case, thus doubts can arise when contradictory results are obtained. It is likely that none of the aforementioned criteria is the best in every situation, so a comparative study using simulated data sets is proposed here, using threshold values suggested by the proponents or those widely used in QSAR modeling. In addition, a different and simple external validation measure, the concordance correlation coefficient (CCC), is proposed and compared with other criteria. Huge data sets were used to study the general behavior of validation measures, and the concordance correlation coefficient was shown to be the most restrictive. On using simulated data sets of a more realistic size, it was found that CCC was broadly in agreement, about 96% of the time, with other validation measures in accepting models as predictive, and in almost all the examples it was the most precautionary. The proposed concordance correlation coefficient also works well on real data sets, where it seems to be more stable, and helps in making decisions when the validation measures are in conflict. Since it is conceptually simple, and given its stability and restrictiveness, we propose the concordance correlation coefficient as a complementary, or alternative, more prudent measure of a QSAR model to be externally predictive. PMID:21800825

  6. Restaurant Scores

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Health Department has developed an inspection report and scoring system. After conducting an inspection of the facility, the Health Inspector calculates a score...

  7. Apgar score

    Science.gov (United States)

    ... baby's: Breathing effort Heart rate Muscle tone Reflexes Skin color Each category is scored with 0, 1, or ... cry, the infant scores 2 for reflex irritability. Skin color: If the skin color is pale blue, the ...

  8. An international study to increase concordance in Ki67 scoring.

    Science.gov (United States)

    Polley, Mei-Yin C; Leung, Samuel C Y; Gao, Dongxia; Mastropasqua, Mauro G; Zabaglo, Lila A; Bartlett, John M S; McShane, Lisa M; Enos, Rebecca A; Badve, Sunil S; Bane, Anita L; Borgquist, Signe; Fineberg, Susan; Lin, Ming-Gang; Gown, Allen M; Grabau, Dorthe; Gutierrez, Carolina; Hugh, Judith C; Moriya, Takuya; Ohi, Yasuyo; Osborne, C Kent; Penault-Llorca, Frédérique M; Piper, Tammy; Porter, Peggy L; Sakatani, Takashi; Salgado, Roberto; Starczynski, Jane; Lænkholm, Anne-Vibeke; Viale, Giuseppe; Dowsett, Mitch; Hayes, Daniel F; Nielsen, Torsten O

    2015-06-01

    Although an important biomarker in breast cancer, Ki67 lacks scoring standardization, which has limited its clinical use. Our previous study found variability when laboratories used their own scoring methods on centrally stained tissue microarray slides. In this current study, 16 laboratories from eight countries calibrated to a specific Ki67 scoring method and then scored 50 centrally MIB-1 stained tissue microarray cases. Simple instructions prescribed scoring pattern and staining thresholds for determination of the percentage of stained tumor cells. To calibrate, laboratories scored 18 'training' and 'test' web-based images. Software tracked object selection and scoring. Success for the calibration was prespecified as Root Mean Square Error of scores compared with reference 1.0 (log2-transformed data). Prespecified success criteria for tissue microarray scoring required intraclass correlation significantly >0.70 but aiming for observed intraclass correlation ?0.90. Laboratory performance showed non-significant but promising trends of improvement through the calibration exercise (mean Root Mean Square Error decreased from 0.6 to 0.4, Maximum Absolute Deviation from 1.6 to 0.9; paired t-test: P=0.07 for Root Mean Square Error, 0.06 for Maximum Absolute Deviation). For tissue microarray scoring, the intraclass correlation estimate was 0.94 (95% credible interval: 0.90-0.97), markedly and significantly >0.70, the prespecified minimum target for success. Some discrepancies persisted, including around clinically relevant cutoffs. After calibrating to a common scoring method via a web-based tool, laboratories can achieve high inter-laboratory reproducibility in Ki67 scoring on centrally stained tissue microarray slides. Although these data are potentially encouraging, suggesting that it may be possible to standardize scoring of Ki67 among pathology laboratories, clinically important discrepancies persist. Before this biomarker could be recommended for clinical use, future research will need to extend this approach to biopsies and whole sections, account for staining variability, and link to outcomes. PMID:25698062

  9. Insulin-like growth factor (IgF)-I, IgF binding protein-3, and prostate cancer: correlation with gleason score

    Scientific Electronic Library Online (English)

    Lívia L., Corrêa; Leonardo, Vieira Neto; Giovanna A. Balarini, Lima; Rafael, Gabrich; Luiz Carlos D. de, Miranda; Mônica R., Gadelha.

    2015-02-01

    Full Text Available Introduction Non-androgenic growth factors are involved in the growth regulation of prostate cancer (PCa). Objective This is the first Brazilian study to correlate, in a population of patients operated for PCa, PSA, total testosterone, insulin-like growth factor-I (IGF-I) and insulin-like growth fa [...] ctor-binding protein-3 (IGFBP-3) with Gleason score and to compare with a control group with benign prostate hyperplasia (BPH). Materials and Methods This retrospective single-center study included 49 men with previously diagnosed PCa and 45 with previously diagnosed BPH. PSA, testosterone, IGF-I, IGFBP-3 were determined in both groups. Results PSA and IGFBP-3 levels were significantly higher in the PCa group as compared to the BPH group (p

  10. Bone mineral density (BMD) composite index scores developed from bone densitometry (DXA and QCT) simplifies correlative and predictive analyses in adolescent's bone health

    International Nuclear Information System (INIS)

    Full text: Introduction and aim. Adolescence is a critical period to accumulate 50-70% of adult's bone mass. Hence, precise bone mass determination is important to monitor BMD development among adolescents in health and disease. It is uncertain at which skeletal site BMD is best predicted by bone-mass determinants. Besides, BMD measured at different sites of an individual can be condensed into a composite-index-score to simplify correlation, outcome prediction and data interpretation. This study describes the development of BMD composite index scores (BMD-CISs) to correlate with bone growth determinants in adolescents. Subjects and methods BMD measurements using DXA: Norland-XR36 (spine, femoral-neck, trochanter and Ward's triangle) and pQCT: Denisiscan-2000 (distal-radius and tibia) were obtained from 101 healthy girls aged 12-15 years to develop the BMD-CISs. Adolescent bone growth predictors (weight, height, pubertal-status, weight-bearing physical-exercise and bone-turnover markers) were evaluated to correlate with BMD-CISs. Factor and principle-component analyses were used to examine the internal structure of 11 BMD skeletal sites and variables, and to create new BMD-CISs which summarize the characteristics of parent BMD-variables. Correlations between the BMD-CISs and parent BMD variables were performed. Univariate and multivariate analysis were performed to associate BMD-CISs with bone growth predictors for examining the strength of correlations and predictions when compared with the original BMD variables. Results. Two independent DXA-generated BMD-CIS and pQCT-generated BMD-CIS were obtained to summarize the 11 original BMD variables. Each BMD-CIS correlated highly with respective DXA or pQCT variable (r=0.32-0.92; P<0.05 - P<0.001). DXA generated BMD-CIS (r=0.24 - 0.73; P<0.05-P<0.001) and pQCT-generated BMD-CIS (r=0.24-0.39; P<0.05-P<0.001) were significantly correlated with most bone growth predictors. In multiple regression analysis, R-square of DXA-BMD-CIS (66.4% vs. 36.3%-66.1%) and pQCT-BMD- CIS (25.1% vs. 12.2%-42.2%) have similar predicting values when compared with parent BMD variables demonstrated that the two new BMD-CISs summarized well the characteristics of the parent BMD variables. Furthermore, areal spinal BMD (by DXA) and volumetric tibial integral BMD (by pQCT) were the BMD sites better predicted by bone-mass determinants (R-squares 0.6-0.8) in multiple regression analysis. Discussion and conclusions. The newly developed BMD-CISs correlated well with original variables and have similar predicting powers when compared with the original BMD variables. The use of BMD-CISs would reduce workload of data analysis and simplify correlation and comparisons between multiple BMD measurements and other predicting variables. Identification of 1-2 skeletal sites better associated with health predictive variables could help reduce the number of skeletal sites for BMD measurement, thus, reducing subject's exposure to unnecessary X ray irradiation. (author)

  11. Critical power concept adapted for the specific table tennis test: comparisons between exhaustion criteria, mathematical modeling, and correlation with gas exchange parameters.

    Science.gov (United States)

    Zagatto, A; Miranda, M F; Gobatto, C A

    2011-07-01

    The purposes of this study were to determine and to compare the critical power concept adapted for the specific table tennis test (critical frequency - C F ) estimated from 5 mathematical models and using 2 different exhaustion criteria (voluntary and technical exhaustions). Also, it was an aim to assess the relationship between C F estimated from mathematical models and respiratory compensation point (RCP), peak oxygen uptake ( V˙O (2PEAK)) and minimal intensity at which V˙O (2PEAK) ( F V˙O (2PEAK)) appears. 9 male table tennis players [18(1) years; 62.3(4.4) kg] performed the maximal incremental test and 3-4 exhaustive exercise bouts to estimate C F s (balls · min (-1)). The exhaustion time and C F obtained were independent of the exhaustion criteria. The C F from 3-parameter model [45.2(7.0)-voluntary, 43.2(5.6)-technical] was lower than C F estimated by linear 2-parameter models, frequency-time (-1) [53.5(3.6)-voluntary, 53.5(3.5)-technical] and total ball thrown-time [52.2(3.5)-voluntary, 52.2(3.5)-technical] but significantly correlated. C F values from 2 linear models were significantly correlated with RCP [47.4(3.4) balls · min (-1)], and C F values of the linear and nonlinear models were correlated with F V˙O (2PEAK) [56.7(3.4) balls · min (-1)]. However, there were no significant correlations between C F values and V˙O (2PEAK) [49.8(1.1)ml · kg (-1) · min (-1)]. The results were not modified by exhaustion criteria. The 2 linear and non-linear 2-parameter models can be used to estimate aerobic endurance in specific table tennis tests. PMID:21563021

  12. Correlation of the National Board of Medical Examiners Emergency Medicine Advanced Clinical Examination given in July to intern American Board of Emergency Medicine in-training examination scores, a predictor of performance?

    Directory of Open Access Journals (Sweden)

    Katherine Hiller

    2015-11-01

    Full Text Available Introduction: There is great variation in the knowledge base of Emergency Medicine (EM interns in July. The first objective knowledge assessment during residency does not occur until eight months later, in February, when the American Board of EM (ABEM administers the in-training examination (ITE. In 2013, the National Board of Medical Examiners (NBME released the EM Advanced Clinical Examination (EM-ACE, an assessment intended for fourth-year medical students. Administration of the EM-ACE to interns at the start of residency may provide an earlier opportunity to assess the new EM residents’ knowledge base. The primary objective of this study was to determine the correlation of the NBME EM-ACE, given early in residency, with the EM ITE. Secondary objectives included determination of the correlation of the United States Medical Licensing Examination (USMLE Step 1 or 2 scores with early intern EM-ACE and ITE scores and the effect, if any, of clinical EM experience on examination correlation. Methods: This was a multi-institutional, observational study. Entering EM interns at six residencies took the EM-ACE in July 2013 and the ABEM ITE in February 2014. We collected scores for the EMACE and ITE, age, gender, weeks of clinical EM experience in residency prior to the ITE, and USMLE Step 1 and 2 scores. Pearson’s correlation and linear regression were performed. Results: Sixty-two interns took the EM-ACE and the ITE. The Pearson’s correlation coefficient between the ITE and the EM-ACE was 0.62. R-squared was 0.5 (adjusted 0.4. The coefficient of determination was 0.41 (95% CI [0.3-0.8]. For every increase of one in the scaled EM-ACE score, we observed a 0.4% increase in the EM in-training score. In a linear regression model using all available variables (EM-ACE, gender, age, clinical exposure to EM, and USMLE Step 1 and Step 2 scores, only the EM-ACE score was significantly associated with the ITE (p<0.05. We observed significant colinearity among the EM-ACE, ITE and USMLE scores. Gender, age and number of weeks of EM prior to the ITE had no effect on the relationship between EM-ACE and the ITE. Conclusion Given early during intern year, the EM-ACE score showed positive correlation with ITE. Clinical EM experience prior to the in-training exam did not affect the correlation.

  13. Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Cass, Jamaica D. [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Varma, Sonal [Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada); Day, Andrew G. [Kingston General Hospital, Kingston K7L 2V7 (Canada); Sangrar, Waheed [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Rajput, Ashish B. [Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada); Raptis, Leda H.; Squire, Jeremy [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Madarnas, Yolanda [Department of Oncology, Queen’s University, Kingston K7L 3N6 (Canada); SenGupta, Sandip K. [Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada); Elliott, Bruce E., E-mail: elliottb@queensu.ca [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada)

    2012-07-18

    There is critical need for improved biomarker assessment platforms which integrate traditional pathological parameters (TNM stage, grade and ER/PR/HER2 status) with molecular profiling, to better define prognostic subgroups or systemic treatment response. One roadblock is the lack of semi-quantitative methods which reliably measure biomarker expression. Our study assesses reliability of automated immunohistochemistry (IHC) scoring compared to manual scoring of five selected biomarkers in a tissue microarray (TMA) of 63 human breast cancer cases, and correlates these markers with clinico-pathological data. TMA slides were scanned into an Ariol Imaging System, and histologic (H) scores (% positive tumor area x staining intensity 0–3) were calculated using trained algorithms. H scores for all five biomarkers concurred with pathologists’ scores, based on Pearson correlation coefficients (0.80–0.90) for continuous data and Kappa statistics (0.55–0.92) for positive vs. negative stain. Using continuous data, significant association of pERK expression with absence of LVI (p = 0.005) and lymph node negativity (p = 0.002) was observed. p53 over-expression, characteristic of dysfunctional p53 in cancer, and Ki67 were associated with high grade (p = 0.032 and 0.0007, respectively). Cyclin D1 correlated inversely with ER/PR/HER2-ve (triple negative) tumors (p = 0.0002). Thus automated quantitation of immunostaining concurs with pathologists’ scoring, and provides meaningful associations with clinico-pathological data.

  14. Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics

    International Nuclear Information System (INIS)

    There is critical need for improved biomarker assessment platforms which integrate traditional pathological parameters (TNM stage, grade and ER/PR/HER2 status) with molecular profiling, to better define prognostic subgroups or systemic treatment response. One roadblock is the lack of semi-quantitative methods which reliably measure biomarker expression. Our study assesses reliability of automated immunohistochemistry (IHC) scoring compared to manual scoring of five selected biomarkers in a tissue microarray (TMA) of 63 human breast cancer cases, and correlates these markers with clinico-pathological data. TMA slides were scanned into an Ariol Imaging System, and histologic (H) scores (% positive tumor area x staining intensity 0–3) were calculated using trained algorithms. H scores for all five biomarkers concurred with pathologists’ scores, based on Pearson correlation coefficients (0.80–0.90) for continuous data and Kappa statistics (0.55–0.92) for positive vs. negative stain. Using continuous data, significant association of pERK expression with absence of LVI (p = 0.005) and lymph node negativity (p = 0.002) was observed. p53 over-expression, characteristic of dysfunctional p53 in cancer, and Ki67 were associated with high grade (p = 0.032 and 0.0007, respectively). Cyclin D1 correlated inversely with ER/PR/HER2-ve (triple negative) tumors (p = 0.0002). Thus automated quantitation of immunostaining concurs with pathologists’ scoring, and provides meaningful associations with clinico-pathological data

  15. Correlação da técnica bottom turn com as notas atribuídas no surf de alto rendimento / Correlation of the bottom turn technique with the scores attributed in high performance surfing

    Scientific Electronic Library Online (English)

    Pedro Caetano, Souza; Marcos Augusto, Rocha; Juarez Vieira do, Nascimento.

    Full Text Available As competições de surf no cenário mundial têm apresentado um alto e homogêneo nível de desempenho entre os atletas. Assim, atentou-se à hipótese de que o bottom turn (BT), curva na base da onda essencial para a construção de manobras subsequentes, pode afetar os resultados alcançados em baterias de [...] surf de alto rendimento. O estudo teve como objetivo quantificar o tempo que os atletas levam na execução de BT em suas ondas e correlacioná-lo com as notas atribuídas. A amostra foi composta por quatro eventos do World Tour de Surf, sendo avaliadas 4 baterias de cada evento, perfazendo um total de 16 baterias investigadas. A análise de cada BT foi realizada por meio do recurso de corte de vídeo disponível no programa Sony Vegas Pro 10.0. A análise estatística foi implementada no software SPSS 18.0, sendo calculado o coeficiente de correlação de Pearson, com nível de significância de p Abstract in english The surf contests worldwide have presented a high and homogeneous level of performance by the athletes. Thus, the hypothesis that the bottom turn (BT), curve on the base of the wave which is essential to the construction of subsequent maneuvers, might influence the results in high performance compet [...] itions. The objective of this study was to quantify the time taken in the execution of the BT by the athletes and correlate it to the scores awarded. The research sample was composed of four contests of the Surfing World Tour. Four heats of each contest were assessed, in a total of sixteen heats studied. The analysis of each BT was performed by using the video split feature available in the Sony Vegas Pro 10.0 software. The statistic analysis was performed with the software SPSS 18.0. The Pearson correlation coefficient was calculated with a significance level of p

  16. Insulin-like growth factor II mRNA binding protein 3 (IMP3 is overexpressed in prostate cancer and correlates with higher Gleason scores

    Directory of Open Access Journals (Sweden)

    Mortezavi Ashkan

    2010-06-01

    Full Text Available Abstract Background The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3 is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Methods Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC. IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. Results IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p Conclusions Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed.

  17. Correlation of the National Board of Medical Examiners Emergency Medicine Advanced Clinical Examination Given in July to Intern American Board of Emergency Medicine in-training Examination Scores: A Predictor of Performance?

    Science.gov (United States)

    Hiller, Katherine; Franzen, Doug; Heitz, Corey; Emery, Matthew; Poznanski, Stacy

    2015-01-01

    Introduction There is great variation in the knowledge base of Emergency Medicine (EM) interns in July. The first objective knowledge assessment during residency does not occur until eight months later, in February, when the American Board of EM (ABEM) administers the in-training examination (ITE). In 2013, the National Board of Medical Examiners (NBME) released the EM Advanced Clinical Examination (EM-ACE), an assessment intended for fourth-year medical students. Administration of the EM-ACE to interns at the start of residency may provide an earlier opportunity to assess the new EM residents’ knowledge base. The primary objective of this study was to determine the correlation of the NBME EM-ACE, given early in residency, with the EM ITE. Secondary objectives included determination of the correlation of the United States Medical Licensing Examination (USMLE) Step 1 or 2 scores with early intern EM-ACE and ITE scores and the effect, if any, of clinical EM experience on examination correlation. Methods This was a multi-institutional, observational study. Entering EM interns at six residencies took the EM-ACE in July 2013 and the ABEM ITE in February 2014. We collected scores for the EM-ACE and ITE, age, gender, weeks of clinical EM experience in residency prior to the ITE, and USMLE Step 1 and 2 scores. Pearson’s correlation and linear regression were performed. Results Sixty-two interns took the EM-ACE and the ITE. The Pearson’s correlation coefficient between the ITE and the EM-ACE was 0.62. R-squared was 0.5 (adjusted 0.4). The coefficient of determination was 0.41 (95% CI [0.3–0.8]). For every increase of one in the scaled EM-ACE score, we observed a 0.4% increase in the EM in-training score. In a linear regression model using all available variables (EM-ACE, gender, age, clinical exposure to EM, and USMLE Step 1 and Step 2 scores), only the EM-ACE score was significantly associated with the ITE (pintern year, the EM-ACE score showed positive correlation with ITE. Clinical EM experience prior to the in-training exam did not affect the correlation. PMID:26594299

  18. A new scoring method with magnetic resonance imagings for prediction of the postoperative results in cervical myelopathy

    Energy Technology Data Exchange (ETDEWEB)

    Kasai, Yuichi; Hatanaka, Setsuo; Nakaseko, Takeshi; Shiokawa, Yasuo; Ogihara, Yoshiro [Mie Univ., Tsu (Japan). School of Medicine; Asama, Shinji

    1995-04-01

    An evaluating method that uses scoring of preoperative magnetic resonance imagings (MRI) (preoperative MRI cumulative score) was devised to predict the postoperative results of dilation of the spinal canal for cervical spondylotic myelopathy. The usefulness of the method is reported. The subjects were 38 patients, and the mean preoperative MRI cumulative score was 9.2 points. The coefficient of correlation between the score and the postoperative improvement rate according to the criteria for results of treatment for spondylotic cervical myelopathy of the neck (established by the Japanese Orthopaedic Association) was -0.462, a significantly negative correlation. (author).

  19. A new scoring method with magnetic resonance imagings for prediction of the postoperative results in cervical myelopathy

    International Nuclear Information System (INIS)

    An evaluating method that uses scoring of preoperative magnetic resonance imagings (MRI) (preoperative MRI cumulative score) was devised to predict the postoperative results of dilation of the spinal canal for cervical spondylotic myelopathy. The usefulness of the method is reported. The subjects were 38 patients, and the mean preoperative MRI cumulative score was 9.2 points. The coefficient of correlation between the score and the postoperative improvement rate according to the criteria for results of treatment for spondylotic cervical myelopathy of the neck (established by the Japanese Orthopaedic Association) was -0.462, a significantly negative correlation. (author)

  20. Assessment of Communications-related Admissions Criteria in a Three-year Pharmacy Program

    Science.gov (United States)

    Tejada, Frederick R.; Lang, Lynn A.; Purnell, Miriam; Acedera, Lisa; Ngonga, Ferdinand

    2015-01-01

    Objective. To determine if there is a correlation between TOEFL and other admissions criteria that assess communications skills (ie, PCAT variables: verbal, reading, essay, and composite), interview, and observational scores and to evaluate TOEFL and these admissions criteria as predictors of academic performance. Methods. Statistical analyses included two sample t tests, multiple regression and Pearson’s correlations for parametric variables, and Mann-Whitney U for nonparametric variables, which were conducted on the retrospective data of 162 students, 57 of whom were foreign-born. Results. The multiple regression model of the other admissions criteria on TOEFL was significant. There was no significant correlation between TOEFL scores and academic performance. However, significant correlations were found between the other admissions criteria and academic performance. Conclusion. Since TOEFL is not a significant predictor of either communication skills or academic success of foreign-born PharmD students in the program, it may be eliminated as an admissions criterion. PMID:26430273

  1. Assessment of Communications-related Admissions Criteria in a Three-year Pharmacy Program.

    Science.gov (United States)

    Parmar, Jayesh R; Tejada, Frederick R; Lang, Lynn A; Purnell, Miriam; Acedera, Lisa; Ngonga, Ferdinand

    2015-08-25

    Objective. To determine if there is a correlation between TOEFL and other admissions criteria that assess communications skills (ie, PCAT variables: verbal, reading, essay, and composite), interview, and observational scores and to evaluate TOEFL and these admissions criteria as predictors of academic performance. Methods. Statistical analyses included two sample t tests, multiple regression and Pearson's correlations for parametric variables, and Mann-Whitney U for nonparametric variables, which were conducted on the retrospective data of 162 students, 57 of whom were foreign-born. Results. The multiple regression model of the other admissions criteria on TOEFL was significant. There was no significant correlation between TOEFL scores and academic performance. However, significant correlations were found between the other admissions criteria and academic performance. Conclusion. Since TOEFL is not a significant predictor of either communication skills or academic success of foreign-born PharmD students in the program, it may be eliminated as an admissions criterion. PMID:26430273

  2. Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70

    Directory of Open Access Journals (Sweden)

    Orme ME

    2012-12-01

    Full Text Available Michelle E Orme,1 Katherine S MacGilchrist,2 Stephen Mitchell,2 Dean Spurden,3 Alex Bird31Icera Consulting, Swindon, Wiltshire, UK; 2Systematic Review Department, Abacus International, Bicester, Oxfordshire, UK; 3Pfizer UK Limited, Tadworth, Surrey, UKBackground: Biologic disease-modifying antirheumatic drugs (bDMARDs extend the treatment choices for rheumatoid arthritis patients with suboptimal response or intolerance to conventional DMARDs. The objective of this systematic review and meta-analysis was to compare the relative efficacy of EU-licensed bDMARD combination therapy or monotherapy for patients intolerant of or contraindicated to continued methotrexate.Methods: Comprehensive, structured literature searches were conducted in Medline, Embase, and the Cochrane Library, as well as hand-searching of conference proceedings and reference lists. Phase II or III randomized controlled trials reporting American College of Rheumatology (ACR criteria scores of 20, 50, and 70 between 12 and 30 weeks' follow-up and enrolling adult patients meeting ACR classification criteria for rheumatoid arthritis previously treated with and with an inadequate response to conventional DMARDs were eligible. To estimate the relative efficacy of treatments whilst preserving the randomized comparisons within each trial, a Bayesian network meta-analysis was conducted in WinBUGS using fixed and random-effects, logit-link models fitted to the binomial ACR 20/50/70 trial data.Results: The systematic review identified 10,625 citations, and after a review of 2450 full-text papers, there were 29 and 14 eligible studies for the combination and monotherapy meta-analyses, respectively. In the combination analysis, all licensed bDMARD combinations had significantly higher odds of ACR 20/50/70 compared to DMARDs alone, except for the rituximab comparison, which did not reach significance for the ACR 70 outcome (based on the 95% credible interval. The etanercept combination was significantly better than the tumor necrosis factor-α inhibitors adalimumab and infliximab in improving ACR 20/50/70 outcomes, with no significant differences between the etanercept combination and certolizumab pegol or tocilizumab. Licensed-dose etanercept, adalimumab, and tocilizumab monotherapy were significantly better than placebo in improving ACR 20/50/70 outcomes. Sensitivity analysis indicated that including studies outside the target population could affect the results.Conclusion: Licensed bDMARDs are efficacious in patients with an inadequate response to conventional therapy, but tumor necrosis factor-α inhibitor combination therapies are not equally effective.Keywords: bDMARD, rheumatoid arthritis, etanercept, systematic review, network meta-analysis, comparative effectiveness

  3. The Influence of Therapist Variance on the Dependability of Therapists' Alliance Scores: A Brief Comment on "The Dependability of Alliance Assessments: The Alliance-Outcome Correlation Is Larger than You Think" (Crits-Christoph et al., 2011)

    Science.gov (United States)

    Baldwin, Scott A.; Imel, Zac E.; Atkins, David C.

    2012-01-01

    Objective: Crits-Christoph, Connolly Gibbons, Hamilton, Ring-Kurtz, and Gallop (2011) used generalizability theory to critique the measurement of the therapeutic alliance in psychotherapy research, showing that the dependability of alliance scores may be quite low, which in turn can lead to attenuated alliance-outcome correlation estimates. Method…

  4. Correlação dos escores de risco com a anatomia coronária na síndrome coronária aguda sem supra-ST / Correlation of risk scores with coronary anatomy in non-ST-elevation acute coronary syndrome

    Scientific Electronic Library Online (English)

    Elizabete Silva dos, Santos; Luciano de Figueiredo, Aguiar Filho; Daniela Menezes, Fonseca; Hugo José, Londero; Rogério Martins, Xavier; Marcos Paulo, Pereira; Luiz, Minuzzo; Roberta de, Souza; Ari, Timerman.

    2013-06-01

    Full Text Available FUNDAMENTO:Há poucas publicações sobre a correlação entre escores de risco e anatomia coronária na síndrome coronária aguda (SCA). OBJETIVO: Correlacionar os escores de risco com a gravidade da lesão coronária na SCA sem supra-ST. MÉTODOS: Foram analisados 582 pacientes entre julho de 2004 e outubro [...] de 2006. Avaliou-se a correlação entre os escores de risco TIMI, GRACE hospitalar e em seis meses com lesão coronária > 50%, por método não paramétrico de Spearman. Modelo de regressão logística múltipla foi realizado para determinar a habilidade preditiva dos escores em discriminar quem terá ou não lesão coronária > 50%. RESULTADOS: Foram 319 (54,8%) homens e a média de idade era 59,9 (± 10,6) anos. Correlação positiva foi observada entre a pontuação dos escores de risco e lesão coronária > 50% (escore de risco TIMI r = 0,363 [p 50% foi: TIMI = 0,704 [IC95% 0,656-0,752; p Abstract in english BACKGROUND: The literature lacks studies regarding the correlation between risk scores and coronary anatomy in acute coronary syndrome (ACS) OBJECTIVE: Correlate risk scores with the severity of the coronary lesion in ACS with non-ST elevation. METHODS: A total of 582 patients were analyzed between [...] July 2004 and October 2006. The correlation between TIMI risk scores and GRACE (hospital and six months) scores was performed for patients with coronary lesion > 50%, using Spearman´s non-parametric method. Multiple regression logistics was used to determine the predictive ability of the scores to discriminate to discriminate who will have a coronary lesion > 50%. RESULTS: Most subjects were male (319 or 54.8%), mean age of 59.9 (± 10.6) years. A positive correlation was observed between risk scores and >coronary lesion > 50% (TIMI r = 0.363 [p 50% was: TIMI = 0.704 [CI95% 0.656-0.752; p

  5. National Institutes of Health (NIH) Chronic GVHD Staging in Severely Affected Patients: Organ and Global Scoring Correlate with Established Indicators of Disease Severity and Prognosis

    OpenAIRE

    Baird, K.; Steinberg, S.M.; Grkovic, L.; Pulanic, D.; Cowen, E.W.; Mitchell, S .A.; Williams, K. M.; Datiles, M.B.; Bishop, R.; Bassim, C.W.; Mays, J.W.; Edwards, D; Cole, K; Avila, D.N.; TAYLOR, T

    2013-01-01

    Between 2004 and 2010, 189 adult patients were enrolled on the National Cancer Institute (NCI) cross-sectional chronic Graft-versus-Host disease (cGVHD) natural history study. Patients were evaluated by multiple disease scales and outcome measures including the 2005 NIH Consensus Project cGVHD severity score. The purpose of this study is to assess the validity of the NIH scoring variables as determinants of disease severity in severely affected patients in order to standardize clinician evalu...

  6. A phase II trial of ixabepilone and cyclophosphamide as neoadjuvant therapy for patients with HER2-negative breast cancer: correlation of pathologic complete response with the 21-gene recurrence score.

    Science.gov (United States)

    Yardley, Denise A; Peacock, Nancy W; Shastry, Mythili; Burris, Howard A; Bechhold, Rebecca G; Hendricks, Carolyn B; Yoshizawa, Carl N; Sing, Amy P; Hainsworth, John D

    2015-11-01

    Ixabepilone and the taxanes have similar activity in the first-line treatment of metastatic breast cancer, and ixabepilone is sometimes effective in taxane-refractory patients. We conducted a phase 2 trial to evaluate ixabepilone in combination with cyclophosphamide as neoadjuvant treatment for patients with locally advanced HER2-negative breast cancer. Response to neoadjuvant treatment was correlated with the baseline 21-gene Recurrence Score(®) (Oncotype DX; Genomic Health Inc, Redwood City, CA). Eligible women with HER2-negative locally advanced breast cancer received ixabepilone 40 mg/m(2) plus cyclophosphamide 600 mg/m(2) on day 1 of each 21-day cycle. Following 6 cycles, patients underwent definitive surgery. Primary endpoint was rate of pathologic complete response (pCR). Breast biopsy tumor samples were obtained at pretreatment and at surgery in patients with residual disease. Tumor specimens were analyzed using the 21-gene assay. One hundred sixty-eight patients (median age 52 years; 45 % triple-negative) were enrolled; 161 (96 %) underwent definitive surgery following neoadjuvant ixabepilone/cyclophosphamide. Overall, 27 patients (17 %) achieved pCR, including 19 of 73 (26 %) triple-negative patients. The most frequently occurring grade 3/4 toxicity was neutropenia (98 patients; 58 %). Recurrence Scores were highly correlated with achievement of pCR (0/36 with low or intermediate Recurrence Scores vs. 19/72 with high Recurrence Scores; p = 0.002). There was high concordance between baseline and post-treatment Recurrence Scores in the 72 patients with paired samples. The combination of ixabepilone and cyclophosphamide yielded a pCR rate of 17 %, similar to other neoadjuvant chemotherapy regimens. Pathologic complete responses occurred only in patients with high-risk baseline Recurrence Scores. PMID:26507191

  7. Genetic effect on apgar score

    OpenAIRE

    Franchi-Pinto Carla; Colletto Glória Maria Duccini Dal; Krieger Henrique; Beiguelman Bernardo

    1999-01-01

    Intraclass correlation coefficients for one- and five-min Apgar scores of 604 twin pairs born at a southeastern Brazilian hospital were calculated, after adjusting these scores for gestational age and sex. The data support a genetic hypothesis only for 1-min Apgar score, probably because it is less affected by the environment than 4 min later, after the newborns have been under the care of a neonatology team. First-born twins exhibited, on average, better clinical conditions than second-born ...

  8. Correlations between FDG PET glucose uptake-MRI gray matter volume scores and apolipoprotein E ?4 gene dose in cognitively normal adults: a cross-validation study using voxel-based multi-modal partial least squares

    OpenAIRE

    Chen, Kewei; Ayutyanont, Napatkamon; Langbaum, Jessica B S; Fleisher, Adam S; Reschke, Cole; Lee, Wendy; Liu, Xiaofen; Gene E Alexander; Bandy, Dan; Caselli, Richard J.; Reiman, Eric M

    2012-01-01

    We previously introduced a voxel-based, multi-modal application of the partial least square algorithm (MMPLS) to characterize the linkage between patterns in a person’s complementary complex datasets without the need to correct for multiple regional comparisons. Here we used it to demonstrate a strong correlation between MMPLS scores to characterize the linkage between the covarying patterns of fluorodeoxyglucose positron emission tomography (FDG PET) measurements of regional glucose metaboli...

  9. Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy - a single centre, open-label study

    LENUS (Irish Health Repository)

    Pontifex, Eliza K

    2011-01-27

    Abstract Introduction With the development of increasing numbers of potential therapeutic agents in inflammatory disease comes the need for effective biomarkers to help screen for drug efficacy and optimal dosing regimens early in the clinical trial process. This need has been recognized by the Outcome Measures in Rheumatology Clinical Trials (OMERACT) group, which has established guidelines for biomarker validation. To seek a candidate synovial biomarker of treatment response in psoriatic arthritis (PsA), we determined whether changes in immunohistochemical markers of synovial inflammation correlate with changes in disease activity scores assessing 28 joints (ΔDAS28) or magnetic resonance imaging synovitis scores (ΔMRI) in patients with PsA treated with a biologic agent. Methods Twenty-five consecutive patients with PsA underwent arthroscopic synovial biopsies and MRI scans of an inflamed knee joint at baseline and 12 weeks after starting treatment with either anakinra (first 10 patients) or etanercept (subsequent 15 patients) in two sequential studies of identical design. DAS28 scores were measured at both time points. Immunohistochemical staining for CD3, CD68 and Factor VIII (FVIII) was performed on synovial samples and scored by digital image analysis (DIA). MRI scans performed at baseline and at 12 weeks were scored for synovitis semi-quantitatively. The ΔDAS28 of the European League Against Rheumatism good response definition (>1.2) was chosen to divide patients into responder and non-responder groups. Differences between groups (Mann Whitney U test) and correlations between ΔDAS28 with change in immunohistochemical and MRI synovitis scores (Spearman\\'s rho test) were calculated. Results Paired synovial samples and MRI scans were available for 21 patients (8 anakinra, 13 etanercept) and 23 patients (8 anakinra, 15 etanercept) respectively. Change in CD3 (ΔCD3) and CD68 expression in the synovial sublining layer (ΔCD68sl) was significantly greater in the disease responders compared to non-responders following treatment (P = 0.005 and 0.013 respectively). ΔCD3, but not ΔCD68 or ΔFVIII, correlated with both ΔDAS28 (r = 0.49, P = 0.025) and ΔMRI (r = 0.58, P = 0.009). Conclusions The correlation of ΔCD3 with ΔDAS28 and ΔMRI following biologic treatment in this cohort contributes to the validation of ΔCD3 as a synovial biomarker of disease response in PsA, and supports the further evaluation of ΔCD3 for predictive properties of future clinical outcomes.

  10. Extravascular lung water index measurement in critically ill children does not correlate with a chest x-ray score of pulmonary edema

    OpenAIRE

    Lemson, J; Die, L. van; Hemelaar, A.E.A.; van Hoeven, J G

    2010-01-01

    INTRODUCTION: Extravascular lung water index (EVLWI) can be measured at the bedside using the transpulmonary thermodilution technique (TPTD). The goal of this study was to compare EVLWI values with a chest x-ray score of pulmonary edema and markers of oxygenation in critically ill children. METHODS: This was a prospective observational study in a pediatric intensive care unit of a university hospital. We included 27 critically ill children with an indication for advanced invasive hemodynamic ...

  11. Biochemical Indices and Sensory Scores of Kunu-zaki Beverages Produced from Sprouted and Unsprouted Guinea Corn and Their Correlations

    OpenAIRE

    C.O. Ibegbulem; P.C. Chikezie

    2014-01-01

    Kunu-zaki beverage is a popular cereal-grain based non-alcoholic drink traditionally produced from sprouted cereal grains like sorghum, millet, maize or their mixtures. Unsprouted grains can also be used, thereby saving time spent during sprouting without compromising sensory property. The present study sought to investigate, in comparative terms, the biochemical indices and sensory scores of Kunu-zaki beverages produced from Sprouted Guinea Corn (SGC) and Unspro...

  12. Correlation between computer-aided dynamic gadolinium-enhanced MRI assessment of inflammation and semi-quantitative synovitis and bone marrow oedema scores of the wrist in patients with rheumatoid arthritis--a cohort study

    DEFF Research Database (Denmark)

    Boesen, Mikael; Kubassova, Olga

    2012-01-01

    Objective. To test the correlation between assessment of inflammation using dynamic contrast-enhanced MRI (DCE-MRI) analysed by a novel computer-aided approach and semi-quantitative scores of synovitis and bone marrow oedema (BME) using the OMERACT-RA MRI Scoring (RAMRIS) system, in the wrist of patients with RA. Methods. Fifty-four RA patients had conventional and DCE-MRI of a symptomatic wrist using a low-field 0.2T extremity scanner. RAMRIS synovitis and BME of the wrist joint were done. DCE-MRI data were analysed in three ways: (i) in all images (fully automated approach), (ii) within a large extended region of interest (ROI) placed around the wrist joint (semi-automated approach) and (iii) within a small ROI placed in the area with most visual enhancement (semi-automated approach). Time spent on each procedure was noted. Spearman's rank correlation test was applied to assess the correlation between RAMRIS and the computer-generated dynamic parameters. Results. RAMRIS synovitis (range 2-9), BME (range 0-39) and the dynamic parameters reflecting the number of enhancing voxels were significantly correlated, especially when an extended ROI around the wrist was used (??=?0.74; P?

  13. The examination of the relationship between YGS scores and music field scores in music teaching programme with special talent examination

    Directory of Open Access Journals (Sweden)

    Turan Sa?er

    2013-03-01

    Full Text Available Every year, with special aptitude exams students are taken to undergraduate programs as a music teacher in Turkey .Although applications for these exam show differences according to the difficulty level of the questions and evaluations criterias, all the areas that would be measured show similarities to each other. The areas showing the similarity are classified as Musical hearing-reading-writing fields (M?OY , musical playing area and musical singing area. Special Ability Test score (ÖYSP Transition to Higher Education Exam scores, as well as forming the points (YGS-P and the weighted scores of Secondary Education (AOBP takes place mainly among the scores of the candidates. It is used according to the circumstances of different coefficients Placement Scores (YP in the calculation. The types of score that form YGS-P and ÖYS, which mainly affect the placemet of the students to the university, the relationship between the musical areas in ÖYSP and all correlations of the areas to each other have been seen as a basical problem of this study.761 candidates who auditioned for Music Education Program in the years 2010-2011 and 2011-2012 academic Inonu University Faculty of Education constitutes the study group . As a result of the analysis made, between the M?OY scores and YGS-P there is a meaningful relationship in positive direction and low level (r =. 08, p <. 05 In adddition, There are positive correlation and low level (r=.32, p<.01; between the musical play and M?OY area points, playing field between the musical scores of M?OY there are positive direction, the low level (r = .21, p <.05 relationship, and it has been found that there is meaningful relationship between musical play area and the Musical direction at a high level. (r=.79, p<.01

  14. Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy--a single centre, open-label study.

    LENUS (Irish Health Repository)

    Pontifex, Eliza K

    2011-01-01

    With the development of increasing numbers of potential therapeutic agents in inflammatory disease comes the need for effective biomarkers to help screen for drug efficacy and optimal dosing regimens early in the clinical trial process. This need has been recognized by the Outcome Measures in Rheumatology Clinical Trials (OMERACT) group, which has established guidelines for biomarker validation. To seek a candidate synovial biomarker of treatment response in psoriatic arthritis (PsA), we determined whether changes in immunohistochemical markers of synovial inflammation correlate with changes in disease activity scores assessing 28 joints (ΔDAS28) or magnetic resonance imaging synovitis scores (ΔMRI) in patients with PsA treated with a biologic agent.

  15. A Simple Clinical Score “TOPRS” to Predict Outcome in Pediatric Emergency Department in a Teaching Hospital in India

    Directory of Open Access Journals (Sweden)

    Ravinder Kumar Soni

    2012-03-01

    Full Text Available Objective: To develop a simple clinical scoring system for severity of illness to help prioritize care and predict outcome in emergency department.Methods: Prospective hospital based observational study. Out of a total of 874 children who attended emergency department in one year, 777 were included in the study. Data was collected at the time of admission in emergency department. The baseline information like age, gender, etc and variables of ‘toprs’ score viz temperature, oxygen saturation, pulse rate, respiratory rate, sensorium and seizures were recorded. Variables were categorized as normal (score zero or abnormal (score 1 based on systemic inflammatory response syndrome (SIRS criteria and criteria mentioned in advanced pediatric life support (APLS and the total scores were computed for each child. The outcome (death/discharge was correlated with the study variables and total score. The predictive ability of score was calculated using receiver operating characteristic (ROC curve analysis.Findings: Of the six variables, temperature, oxygen saturation and respiratory rate were found to be significantly associated with mortality. Mortality increased with the increase in the number of abnormal variables. Based on the regression coefficients, maximum possible score was 6.68. The predictive ability of score was 81.7 calculated using ROC curve. Maximum discrimination was observed at a score of 2.5.Conclusion: For triage in emergency, any patient with 2 or more abnormal variables should be closely monitored and evaluated. These patients require admission as they have a potential risk of death.

  16. Scoring Difficulty of the WPPSI Geometric Design Subtest

    Science.gov (United States)

    Sattler, Jerome M.

    1976-01-01

    The study investigated levels of agreement among graduate students (n=14) and school psychologists (n=18) in scoring drawings for the 10 designs on the WPPSI Geometric Design subtest. Considerable scoring disagreement occurred within each group. Results suggest careful study of the WPPSI scoring criteria is needed to achieve scoring proficiency.…

  17. Adrenoleucodistrofia ligada ao X: correlação entre o escore de Loes e parâmetros do tensor de difusão / X-linked adrenoleukodystrophy: correlation between Loes score and diffusion tensor imaging parameters

    Scientific Electronic Library Online (English)

    Sergio Eiji, Ono; Arnolfo de, Carvalho Neto; Emerson Leandro, Gasparetto; Luiz Otávio de Mattos, Coelho; Dante Luiz, Escuissato; Carmem Maria Sales, Bonfim; Lisandro Lima, Ribeiro.

    2014-12-01

    Full Text Available Objetivo: Avaliar a correlação dos parâmetros do tensor de difusão com o escore de Loes e se os parâmetros do tensor de difusão poderiam indicar alterações estruturais precoces. Materiais e Métodos: As medidas do tensor de difusão foram obtidas em 30 exames de 14 pacientes com adrenoleucodistrofi [...] a ligada ao X e foram correlacionadas com o escore de Loes. Um grupo controle de 28 pacientes masculinos foi avaliado para estabelecer medidas do tensor de difusão pareadas por idade. Análises estatísticas intra e interobservador foram feitas. Resultados: As medidas do tensor de difusão apresentam forte correlação com o escore de Loes segundo o coeficiente de Pearson (r), com valores de –0,86, 0,89, 0,89 e 0,84 para a fração de anisotropia e difusibilidades média, radial e axial (p Abstract in english Objective: The present study was aimed at evaluating the correlation between diffusion tensor imaging parameters and Loes score as well as whether those parameters could indicate early structural alterations. Materials and Methods: Diffusion tensor imaging measurements were obtained in 30 studies [...] of 14 patients with X-linked adrenoleukodystrophy and were correlated with Loes scores. A control group including 28 male patients was created to establish agematched diffusion tensor imaging measurements. Inter- and intraobserver statistical analyses were undertaken. Results: Diffusion tensor imaging measurements presented strong Pearson correlation coefficients (r) of –0.86, 0.89, 0.89 and 0.84 for fractional anisotropy and mean, radial and axial diffusivities (p

  18. Adrenoleucodistrofia ligada ao X: correlação entre o escore de Loes e parâmetros do tensor de difusão / X-linked adrenoleukodystrophy: correlation between Loes score and diffusion tensor imaging parameters

    Scientific Electronic Library Online (English)

    Sergio Eiji, Ono; Arnolfo de, Carvalho Neto; Emerson Leandro, Gasparetto; Luiz Otávio de Mattos, Coelho; Dante Luiz, Escuissato; Carmem Maria Sales, Bonfim; Lisandro Lima, Ribeiro.

    2014-12-01

    Full Text Available Objetivo: Avaliar a correlação dos parâmetros do tensor de difusão com o escore de Loes e se os parâmetros do tensor de difusão poderiam indicar alterações estruturais precoces. Materiais e Métodos: As medidas do tensor de difusão foram obtidas em 30 exames de 14 pacientes com adrenoleucodistrofia [...] ligada ao X e foram correlacionadas com o escore de Loes. Um grupo controle de 28 pacientes masculinos foi avaliado para estabelecer medidas do tensor de difusão pareadas por idade. Análises estatísticas intra e interobservador foram feitas. Resultados: As medidas do tensor de difusão apresentam forte correlação com o escore de Loes segundo o coeficiente de Pearson (r), com valores de –0,86, 0,89, 0,89 e 0,84 para a fração de anisotropia e difusibilidades média, radial e axial (p Abstract in english Objective: The present study was aimed at evaluating the correlation between diffusion tensor imaging parameters and Loes score as well as whether those parameters could indicate early structural alterations. Materials and Methods: Diffusion tensor imaging measurements were obtained in 30 studies o [...] f 14 patients with X-linked adrenoleukodystrophy and were correlated with Loes scores. A control group including 28 male patients was created to establish agematched diffusion tensor imaging measurements. Inter- and intraobserver statistical analyses were undertaken. Results: Diffusion tensor imaging measurements presented strong Pearson correlation coefficients (r) of –0.86, 0.89, 0.89 and 0.84 for fractional anisotropy and mean, radial and axial diffusivities (p

  19. Rape Myth Acceptance, Hypermasculinity, and SAT Scores as Correlates of Moral Development: Understanding Sexually Aggressive Attitudes in First-Year College Men

    Science.gov (United States)

    Tatum, Jerry L.; Foubert, John D.

    2009-01-01

    Male perpetrated sexual aggression has long been recognized as a serious problem on college campuses. The purpose of this multiple regression correlation study was to assess the relationship between levels of moral development (measured by the Defining Issues Test) and the degree to which first-year college men (N = 161) ascribed to rape…

  20. Rape Myth Acceptance, Hypermasculinity, and SAT Scores as Correlates of Moral Development: Understanding Sexually Aggressive Attitudes in First-Year College Men

    Science.gov (United States)

    Tatum, Jerry L.; Foubert, John D.

    2009-01-01

    Male perpetrated sexual aggression has long been recognized as a serious problem on college campuses. The purpose of this multiple regression correlation study was to assess the relationship between levels of moral development (measured by the Defining Issues Test) and the degree to which first-year college men (N = 161) ascribed to rape…

  1. Coupling of system thermal–hydraulics and Monte-Carlo code: Convergence criteria and quantification of correlation between statistical uncertainty and coupled error

    International Nuclear Information System (INIS)

    Highlights: • Coupling of Monte Carlo code Serpent and thermal–hydraulics code RELAP5. • A convergence criterion is developed based on the statistical uncertainty of power. • Correlation between MC statistical uncertainty and coupled error is quantified. • Both UO2 and MOX single assembly models are used in the coupled simulation. • Validation of coupling results with a multi-group transport code DeCART. - Abstract: Coupled multi-physics approach plays an important role in improving computational accuracy. Compared with deterministic neutronics codes, Monte Carlo codes have the advantage of a higher resolution level. In the present paper, a three-dimensional continuous-energy Monte Carlo reactor physics burnup calculation code, Serpent, is coupled with a thermal–hydraulics safety analysis code, RELAP5. The coupled Serpent/RELAP5 code capability is demonstrated by the improved axial power distribution of UO2 and MOX single assembly models, based on the OECD-NEA/NRC PWR MOX/UO2 Core Transient Benchmark. Comparisons of calculation results using the coupled code with those from the deterministic methods, specifically heterogeneous multi-group transport code DeCART, show that the coupling produces more precise results. A new convergence criterion for the coupled simulation is developed based on the statistical uncertainty in power distribution in the Monte Carlo code, rather than ad-hoc criteria used in previous research. The new convergence criterion is shown to be more rigorous, equally convenient to use but requiring a few more coupling steps to converge. Finally, the influence of Monte Carlo statistical uncertainty on the coupled error of power and thermal–hydraulics parameters is quantified. The results are presented such that they can be used to find the statistical uncertainty to use in Monte Carlo in order to achieve a desired precision in coupled simulation

  2. Correlations of scores on the Gifted Evaluation Scale with those on WISC-III and Kaufman Brief Intelligence Test for students referred for Gifted Evaluation.

    Science.gov (United States)

    Levinson, E M; Folino, L

    1994-04-01

    29 students (M age of 8.0 yr.) who were referred for evaluation were administered the Gifted Evaluation Scale, the Kaufman Brief Intelligence Test, and the WISC-III. Paired t tests comparing the mean GES Quotient with the K-BIT mean IQ and WISC-III Verbal, Performance, and Full Scale IQs yielded no statistically significant differences (range of IQs = 120.6 to 122.9). While the significant correlation of the GES Quotient and WISC-III Performance IQ was .42, r = -.37 for the GES Quotient and WISC-III Verbal IQ. No significant correlation was found between the GES Quotient and the WISC-III Full Scale or K-BIT IQs. The limitations and implications of the study, with regard to the use of the Gifted Evaluation Scale, are discussed. PMID:8197281

  3. Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma A?42 Concentrations in Down Syndrome Young Adults

    Science.gov (United States)

    Hoyo, Laura Del; Xicota, Laura; Sánchez-Benavides, Gonzalo; Cuenca-Royo, Aida; de Sola, Susana; Langohr, Klaus; Fagundo, Ana B.; Farré, Magí; Dierssen, Mara; de la Torre, Rafael

    2015-01-01

    Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal fluency are strongly impaired domains; nearly all adults show neuropathology of Alzheimer’s disease (AD), including amyloid deposition by their fifth decade of life. In the general population, verbal fluency deficits are considered a strong AD predictor being the semantic verbal fluency task (SVFT) a useful tool for enhancing early diagnostic. However, there is a lack of information about the association between the semantic verbal fluency pattern (SVFP) and the biological amyloidosis markers in DS. In the current study, we used the SVFT in young adults with DS to characterize their SVFP, assessing total generated words, clustering, and switching. We then explored its association with early indicators of dementia, adaptive behavior and amyloidosis biomarkers, using the Dementia Questionnaire for Persons with Intellectual Disability (DMR), the Adaptive Behavior Assessment System-Second Edition (ABAS-II), and plasma levels of A? peptides (A?40 and A?42), as a potent biomarker of AD. In DS, worse performance in SVFT and poorer communication skills were associated with higher plasma A?42 concentrations, a higher DMR score and impaired communication skills (ABAS–II). The total word production and switching ability in SVFT were good indicators of plasma A?42 concentration. In conclusion, we propose the SVFT as a good screening test for early detection of dementia and amyloidosis in young adults with DS. PMID:26635555

  4. Assessment of an implant-skin interface scoring system for external skeletal fixation of dogs.

    Science.gov (United States)

    McDonald-Lynch, Mischa B; Marcellin-Little, Denis J; Roe, Simon C; Lascelles, B Duncan X; Trumpatori, Brian J; Griffith, Emily H

    2015-11-01

    OBJECTIVE To assess intraobserver repeatability and interobserver and in vivo versus photographic agreement of a scoring system for the implant-skin interface (ISI) of external skeletal fixation (ESF). SAMPLE 42 photographs of ISIs from 18 dogs for interobserver agreement and intraobserver repeatability and 27 photographs of ISIs from 6 dogs for in vivo versus photograph agreement. PROCEDURES An ISI inflammation scoring system was developed. It included scales for 6 metrics (erythema, drainage amount, drainage type, swelling, hair loss or lack of hair regrowth, and granulation tissue). Photographs of the ISI of ESF were obtained by use of a standard protocol and evaluated to determine intraobserver repeatability and interobserver agreement (Cronbach ?; 4 raters) of the ISI score. Agreement between in vivo and photographic ISI scores (2 raters) and correlation between median scores across metrics were evaluated. RESULTS 42 photographs met the inclusion criteria. Overall intraclass correlation coefficients ranged from 0.922 to 0.975. Interobserver overall Cronbach ? ranged from 0.835 to 0.943. For in vivo versus photographic assessment, 27 ISIs in 6 dogs and their photographs were evaluated. The Cronbach ? for both raters ranged from 0.614 to 0.938. Overall, the Cronbach ? ranged from 0.725 to 0.932. Mean photographic scores were greater than mean in vivo scores for each metric. Pearson correlation coefficients ranged from 0.221 to 0.923. Erythema, swelling, and granulation were correlated with all other metrics. CONCLUSIONS AND CLINICAL RELEVANCE In this study, an ISI scoring system used in this study had high repeatability and agreement and may therefore be considered for use in clinical situations. Photographic scores were not equivalent to in vivo scores and should not be used interchangeably. PMID:26512537

  5. Comparison between Oncotype DX test and standard prognostic criteria in estrogen receptor positive early-stage breast cancer

    Directory of Open Access Journals (Sweden)

    Marcelo Roberto Pereira Freitas

    2011-09-01

    Full Text Available Objective: To compare the prognosis estimated by standardprognostic criteria versus the prognosis estimated by the OncotypeDX. Methods: A retrospective study was performed on 22 patientswith positive estrogen receptor, early-stage breast cancer whohad an Oncotype DX recurrence score available. Results: Kappavalue between Oncotype DX and standard prognostic criteriawas: Adjuvant! (K = 0.091, Adjuvant! (Transbig (K = 0.182 andNational Comprehensive Cancer Network (K = 0.091. The Fisher’sexact test did not show correlation between Oncotype and standardprognostic criteria. Conclusion: Standard prognostic criteria showedno correlation with Oncotype DX.

  6. Will the truth come out? the effect of deception, age, status, coaching, and social skills on CBCA scores.

    Science.gov (United States)

    Vrij, Aldert; Akehurst, Lucy; Soukara, Stavroula; Bull, Ray

    2002-06-01

    The impact of Veracity, Age, Status (witness or suspect), Coaching (informed or uninformed regarding CBCA), and Social Skills (social anxiety, social adroitness, and self-monitoring) on Criteria-Based Content Analysis scores was examined. Participants (aged 5-6, 10-11, 14-15, and undergraduates) participated in a "rubbing the blackboard" event. In a subsequent interview they told the truth or lied about the event. They were accused of having rubbed the blackboard themselves (suspect condition) or were thought to have witnessed the event (witness condition), and were or were not taught some CBCA criteria prior to the interview. CBCA scores discriminated between liars and truth tellers in children, adults, witnesses, and suspects. However, truth tellers obtained higher CBCA scores than liars only when the liars were uninformed about CBCA. CBCA scores were correlated with social skills. It is argued that thesefindings should caution those who believe that the validity of CBCA has been conclusively demonstrated. PMID:12061619

  7. Correlation of myocardial perfusion single photon emission computed tomography with coronary artery calcium score in coronary artery disease- An Indian perspective

    International Nuclear Information System (INIS)

    Full text: Objectives: The consequences of atherosclerosis can be detected by coronary artery calcium score (CACS) and stress induced myocardial ischemia on myocardial perfusion single photon emission computed tomography (MPS). We assessed the relationship between stress induced myocardial ischemia on (MPS) and magnitude of CACS by 64 slice computed tomography (CT) in patients undergoing both tests. Methods: Our study included 59 patients with no earlier history of coronary artery disease (CAD) of both sexes (males-47, females-12) in age group of 34-69 years. Our patients were referred by cardiologists after they underwent CACS. Of these 37 patients (63%) presented with symptoms which included chest pain (non-anginal, anginal, atypical) presence or absence of shortness of breath, and rest (37%) were asymptomatic. For each patient coronary risk factors were noted. All these patients underwent CACS and rest and stress MPS one-day protocol with Tc99m sestamibi within 7 days. According to CACS and symptoms, patients were divided into four groups, group A - asymptomatic 100 n=13, group D - symptomatic >100 (n=11). The incidence of inducible ischemia in MPS was compared to the magnitude of CACS abnormality. Results: There were 21 patients (36%) with ischemic MPS. According to groups, group A - 11%(n=1), groupB- 38%(n=10), groupC- 30%(n=4) and group D- 54%(n=6) had ischemic MPS. From the above we observed that incidence of ischemic MPS is more with increasing CACS. And also it is noted that it is more frequent in patients who presented with symptoms irrespective of CACS who are at short-term risk. In negative MPS, CACS may be useful in long term risk stratification in finding out subclinical atherosclerosis. Conclusion: The general perception is that the CACS is a good tool for long-term risk stratification but it may be applicable to those patients with no significant risk factors. When there are risk factors MPS is a better indicator for risk stratification for CAD irrespective of CACS. Further studies incorporating prognostic follow- up are required. (author)

  8. Is the FAMACHA chart suitable for every breed? Correlations between FAMACHA scores and different traits of mucosa colour in naturally parasite infected sheep breeds.

    Science.gov (United States)

    Moors, Eva; Gauly, Matthias

    2009-12-01

    Infections with gastrointestinal nematodes, in particular Haemonchus contortus, are worldwide one of the most important factors causing high economic losses in sheep production. Different methods for detecting infections with H. contortus have been described, such as, e.g. the FAMACHA system, which categorises the colour of the conjunctivae from red to pale. When H. contortus is not the predominant parasite, the FAMACHA chart might not be suitable to detect nematode infections, because of the lack of a blood feeding parasite. Otherwise breed-specific differences in the colour of the mucosa could be responsible for the limitations of the FAMACHA system. The aim of the study was to compare different methods of measuring mucosa colour in the German sheep breeds Black Head Mutton (BH) and Leine sheep (LE). In a total of 232 6-months-old lambs, the colour of mucosa was measured using the FAMACHA chart (conjunctivae) as well as the colour analyser Minolta Chroma Meter CR-200b (gingivae). Faeces and blood samples were taken at the same time to determine faecal egg counts per gram faeces (FEC) and the packed cell volume (PCV), respectively. Lambs grazed on contaminated pastures and no anthelmintic treatment was used. Lambs were moderately infected with gastrointestinal nematodes with no significant difference between the two breeds (P>0.05). The prevalence of H. contortus was 23%, based on larvae differentiation of coproculture. There was no significant correlation between FEC and PCV, nor FEC and FAMACHA (P>0.05). Significant differences (P or =0.27l/l), as shown by significant correlation coefficients between PCV and Chroma and HA, respectively. It can be concluded, that the measurement of mucosa colour with a colour analyser is more sensitive in detecting anaemic states in sheep, compared to the FAMACHA chart. However, because the colour analyser is not suited for measurements in the field, an adaptation of the FAMACHA colour scales for different sheep breeds might be required. PMID:19699035

  9. Magnetic resonance imaging versus Acute Physiology And Chronic Healthy Evaluation II score in predicting the severity of acute pancreatitis

    International Nuclear Information System (INIS)

    Objective: To study the correlation between established magnetic resonance (MR) imaging criteria of disease severity in acute pancreatitis and the Acute Physiology And Chronic Healthy Evaluation II (APACHE II) score, and to assess the utility of each prognostic indicators in acute pancreatitis. Materials and methods: In this study there were 94 patients with acute pancreatitis (AP), all had abdominal MR imaging. MR findings were categorized into edematous and necrotizing AP and graded according to the MR severity index (MRSI). The APACHE II score was calculated within 24 h of admission, and local complications, death, duration of hospitalization and ICU were recorded. Statistical analysis was performed to determine their correlation. Results: In patients with pancreatitis, no significant correlation can be found between the APACHE II score and the MRSI score (P = 0.196). The MRSI score correlated well with morbidity (P = 0.006) but not with mortality (P = 0.137). The APACHE II score correlated well with mortality (P = 0.002) but not with the morbidity (P = 0.112). The MRSI score was superior to the APACHE II score as a predictor of the length of hospitalization (r = 0.52 vs. r = 0.35). A high MRSI and APACHE II score correlated with the need for being in the intensive care unit (ICU) (P = 0.000 and P = 0.000, respectively). Conclusion: In patients with pancreatitis, MRSI is superior to APACHE II in assessing local complications from pancreatitis but has a limited role in determining systemic complications in which the APACHE II score excels.

  10. Checklist for Evaluating SREB-SCORE Learning Objects

    Science.gov (United States)

    Southern Regional Education Board (SREB), 2007

    2007-01-01

    This checklist is based on "Evaluation Criteria for SREB-SCORE Learning Objects" and is designed to help schools and colleges determine the quality and effectiveness of learning objects. It is suggested that each learning object be rated to the extent to which it meets the criteria and the SREB-SCORE definition of a learning object. A learning…

  11. Knowing the Score

    Science.gov (United States)

    Strouse, Lewis H.

    2009-01-01

    Before rehearsals begin, conductors need to thoroughly study the score. What elements go into a comprehensive score preparation? To learn music scores efficiently, having a detailed and systematic study method helps. The author has developed a score preparation guide that works for directors of bands, choruses, and orchestras, even when there's…

  12. Assessment of lung disease in children with cystic fibrosis using hyperpolarized 3-Helium MRI: comparison with Shwachman score, Chrispin-Norman score and spirometry

    International Nuclear Information System (INIS)

    This study assesses the feasibility of hyperpolarized 3-Helium MRI in children with cystic fibrosis (CF) and correlates the findings with standard clinical parameters based on chest radiograph (CXR) and pulmonary function tests (PFT). An uncontrolled, observational study in eighteen children with cystic fibrosis aged 5 - 17 years (median 12.1 years), with different severity of disease was carried out. All subjects underwent routine clinical assessment including PFT and standard auxology; CXR was obtained and Shwachman and Chrispin-Norman scores calculated. Hyperpolarized 3-He magnetic resonance imaging (MRI) was carried out using a spin-exchange polarizer and a whole body 1.5 T scanner. Ventilation distribution images were obtained during a 21-second breath-hold and scored according to previously defined criteria. Spearman's non-parametric correlations test was performed to assess for statistical significance at the p<0.05 level. The children tolerated the procedure well. No desaturation events were observed during 3-He MRI. A significant, albeit moderate, correlation was found between MRI score and FEV1% predicted (r=-0.41; p=0.047) and FVC% predicted (r=-0.42; p=0.04), while there were trends of correlations between Shwachman score and MRI score (r=-0.38; p=0.06) and Shwachman score and FEV1% predicted (r=0.39; p=0.055). The feasibility of hyperpolarized 3-He MRI in children with CF was demonstrated. MRI appears to be able to demonstrate functional lung changes, although correlations with routine clinical tests are only moderate to poor. This non-ionising radiation technique could be useful for monitoring lung disease and assessing therapy in this patient population. (orig.)

  13. Assessment of lung disease in children with cystic fibrosis using hyperpolarized 3-Helium MRI: comparison with Shwachman score, Chrispin-Norman score and spirometry

    Energy Technology Data Exchange (ETDEWEB)

    Beek, Edwin J.R. van [University of Sheffield, Unit of Academic Radiology, Sheffield (United Kingdom); University of Iowa, Department of Radiology, Carver College of Medicine, Iowa City (United States); University of Iowa, Department of Radiology, Iowa City, IA (United States); Hill, Catherine; Woodhouse, Neil; Fichele, Stanislao; Fleming, Sally; Wild, Jim M. [University of Sheffield, Unit of Academic Radiology, Sheffield (United Kingdom); Howe, Bridget; Bott, Sandra; Taylor, Christopher J. [University of Sheffield, Academic Unit of Child Health, Sheffield (United Kingdom)

    2007-04-15

    This study assesses the feasibility of hyperpolarized 3-Helium MRI in children with cystic fibrosis (CF) and correlates the findings with standard clinical parameters based on chest radiograph (CXR) and pulmonary function tests (PFT). An uncontrolled, observational study in eighteen children with cystic fibrosis aged 5 - 17 years (median 12.1 years), with different severity of disease was carried out. All subjects underwent routine clinical assessment including PFT and standard auxology; CXR was obtained and Shwachman and Chrispin-Norman scores calculated. Hyperpolarized 3-He magnetic resonance imaging (MRI) was carried out using a spin-exchange polarizer and a whole body 1.5 T scanner. Ventilation distribution images were obtained during a 21-second breath-hold and scored according to previously defined criteria. Spearman's non-parametric correlations test was performed to assess for statistical significance at the p<0.05 level. The children tolerated the procedure well. No desaturation events were observed during 3-He MRI. A significant, albeit moderate, correlation was found between MRI score and FEV1% predicted (r=-0.41; p=0.047) and FVC% predicted (r=-0.42; p=0.04), while there were trends of correlations between Shwachman score and MRI score (r=-0.38; p=0.06) and Shwachman score and FEV1% predicted (r=0.39; p=0.055). The feasibility of hyperpolarized 3-He MRI in children with CF was demonstrated. MRI appears to be able to demonstrate functional lung changes, although correlations with routine clinical tests are only moderate to poor. This non-ionising radiation technique could be useful for monitoring lung disease and assessing therapy in this patient population. (orig.)

  14. Using Minimum Acceptable GRE Scores for Graduate Admissions Suppresses Diversity

    Science.gov (United States)

    Miller, Casey

    2014-01-01

    I will present data showing that significant performance disparities on the GRE general test exist based on the test taker's race and gender [1]. Because of the belief that high GRE scores qualify one for graduate studies, the diversity issues faced by STEM fields may originate, at least in part, in misuse of the GRE scores by graduate admissions committees. I will quantitatively demonstrate this by showing that the combination of a hard cut-off and the different score distributions leads to the systematic underrepresentation of certain groups. I will present data from USF’s PhD program that shows a lack of correlation between GRE scores and research ability; similar null results are emerging from numerous other programs. I will then discuss how assessing non-cognitive competencies in the selection process may lead to a more enlightened search for the next generation of scientists. [1] C. W. Miller, "Admissions Criteria and Diversity in Graduate School", APS News Vol 22, Issue 2, The Back Page (2013) http://www.aps.org/publications/apsnews/201302/backpage.cfm

  15. CT densitovolumetry in children with obliterative bronchiolitis: correlation with clinical scores and pulmonary function test results / Densitovolumetria pulmonar por TC em criancas com bronquiolite obliterante: correlacao com escores clinicos e testes de funcao pulmonar

    Scientific Electronic Library Online (English)

    Helena, Mocelin; Gilberto, Bueno; Klaus, Irion; Edson, Marchiori; Edgar, Sarria; Guilherme, Watte; Bruno, Hochhegger.

    2013-12-01

    Full Text Available OBJETIVO: Determinar as correlações entre o volume de aprisionamento aéreo em relação ao volume pulmonar total (AA%) e parâmetros clínicos e funcionais em crianças com bronquiolite obliterante (BO). MÉTODOS: Técnicas de pós-processamento de imagem foram usadas em imagens de TC de 19 crianças c [...] om BO para quantificar AA% por meio de um limiar fixo de ?950 UH (AA%950) e de limiares selecionados por meio de máscaras de densidade (AA%MD). Os pacientes foram divididos em três grupos, de acordo com a gravidade de AA%. Foram examinadas as correlações entre AA% e a saturação de oxigênio (SO2) em repouso, a distância percorrida no teste de caminhada de seis minutos (DTC6), a SO2 mínima durante o teste de caminhada de seis minutos (SO2_TC6), a CVF, o VEF1, a relação VEF1/CVF e parâmetros clínicos. RESULTADOS: A DTC6 foi maior nos pacientes com maiores volumes pulmonares normais (r = 0,53). Na amostra como um todo, encontramos (antes e depois da exclusão de valores extremos, respectivamente), correlações estatisticamente significativas entre AA%950 e o escore clínico (r = 0,72; 0,80), a CVF (r = 0,24; 0,59), o VEF1 (r = ?0,58; ?0,67) e a relação VEF1/CVF (r = ?0,53; r = ?0,62), bem como entre AA%MD e o escore clínico (r = 0,58; r = 0,63), a SO2 em repouso (r = ?0,40; r = ?0,61), a SO2_TC6 (r = ?0,24; r = ?0,55), a CVF (r = ?0,44; r = ?0,80), o VEF1 (r = ?0,65; r = ?0,71) e a relação VEF1/CVF (r = ?0,41; r = ?0,52). CONCLUSÕES: Os resultados deste estudo mostram que AA% correlaciona-se significativamente com escores clínicos e testes de função pulmonar em crianças com BO. Abstract in english OBJECTIVE: To determine whether air trapping (expressed as the percentage of air trapping relative to total lung volume [AT%]) correlates with clinical and functional parameters in children with obliterative bronchiolitis (OB). METHODS: CT scans of 19 children with OB were post-processed for A [...] T% quantification with the use of a fixed threshold of ?950 HU (AT%950) and of thresholds selected with the aid of density masks (AT%DM). Patients were divided into three groups by AT% severity. We examined AT% correlations with oxygen saturation (SO2) at rest, six-minute walk distance (6MWD), minimum SO2 during the six-minute walk test (6MWT_SO2), FVC, FEV1, FEV1/FVC, and clinical parameters. RESULTS: The 6MWD was longer in the patients with larger normal lung volumes (r = 0.53). We found that AT%950 showed significant correlations (before and after the exclusion of outliers, respectively) with the clinical score (r = 0.72; 0.80), FVC (r = 0.24; 0.59), FEV1 (r = ?0.58; ?0.67), and FEV1/FVC (r = ?0.53; r = ?0.62), as did AT%DM with the clinical score (r = 0.58; r = 0.63), SO2 at rest (r = ?0.40; r = ?0.61), 6MWT_SO2 (r = ?0.24; r = ?0.55), FVC (r = ?0.44; r = ?0.80), FEV1 (r = ?0.65; r = ?0.71), and FEV1/FVC (r = ?0.41; r = ?0.52). CONCLUSIONS: Our results show that AT% correlates significantly with clinical scores and pulmonary function test results in children with OB.

  16. Fratura na coluna vertebral por mieloma múltiplo: correlação entre sobrevida e índices de Tomita e Tokuhashi Fractura de la columna vertebral por mieloma múltiple: correlación entre sobrevida e índices de Tomita y Tokuhashi Multiple myeloma and vertebral fractures: correlation between survival rate and Tomita and Tokuhashi scores

    Directory of Open Access Journals (Sweden)

    Osmar Avanzi

    2009-03-01

    Full Text Available OBJETIVO: o mieloma múltiplo (MM é a neoplasia óssea primária mais freqüente na coluna vertebral. Em razão da grande morbi-mortalidade destas lesões, discute-se qual o melhor tratamento nestes pacientes. Na prática, observamos similaridade das opções de tratamento entre os pacientes portadores de metástases ósseas e MM. Os índices de sobrevida de Tomita e Tokuhashi são utilizados com o intuito de auxiliar na escolha do tratamento nos portadores de metástases. Faltam estudos sobre a aplicabilidade destes índices em pacientes portadores de MM. Neste trabalho vamos avaliar a aplicabilidade dos índices de Tomita e Tokuhashi nos pacientes portadores de MM e lesão vertebral. MÉTODOS: estudo retrospectivo mediante avaliação de prontuários e radiografias de portadores de MM por meio da aplicação dos critérios de Tomita e Tokuhashi. RESULTADOS: em um ano, 19 (63,3% estavam vivos, em dois anos 13 (43,3% e em cinco anos quatro (13,3% pacientes estavam vivos. Não houve correlação entre os índices (Tomita e Tokuhashi e a taxa de sobrevida nestes pacientes (p= 0,2255. CONCLUSÃO: há necessidade de adaptação dos índices de Tomita e Tokuhashi para apresentarem aplicabilidade nos portadores de MM na coluna.OBJETIVO: el Mieloma Múltiple (MM es la neoplasia ósea primaria más frecuente en la columna vertebral. En razón de la gran morbimortalidad de estas lesiones, se discute cuál sería el mejor tratamiento en estos pacientes. En la práctica observamos semejanza de las opciones de tratamiento entre los pacientes portadores de metástasis óseas y MM. Los índices de sobrevida de Tomita y Tokuhashi son utilizados con el objetivo de auxiliar en la opción del tratamiento en los portadores de metástasis. Faltan estudios sobre la aplicabilidad de estos índices en pacientes portadores de MM. En este trabajo vamos a evaluar la aplicabilidad de los índices de Tomita y Tokuhashi en los pacientes portadores de MM y lesión vertebral. MÉTODOS: estudio retrospectivo mediante evaluación de historias clínicas y radiografías de portadores de MM por medio de la aplicación de los criterios de Tomita y Tokuhashi. RESULTADOS: En un año 19 estuvieron vivos (63.3%, en 2 años fueron 13 (43.3% y en 5 años fueron 4 los que estuvieron vivos (13.3%. No hubo correlación entre los índices (Tomita y Tokuhashi y la tasa de sobrevida en estos pacientes (p= 0.2255. CONCLUSIÓN: Hay necesidad de adaptación de los índices de Tomita y Tokuhashi para presentar una aplicabilidad en los portadores de MM en la columna.OBJECTIVE: multiple myeloma (MM is the most common primary neoplasm tumor in the spine. Due to the high morbidity and mortality of these spinal lesions, it is of important to discuss the best treatment in these patients. In clinical practice, there are similarities in the treatment options for patients with bone metastasis and MM. The survival rates of Tomita and Tokuhashi scores are used in order to assist in the choice of treatment patients with metastasis. No studies about the applicability of these scores in patients with MM were found. The objective of this study is to evaluate the applicability of Tomita and Tokuhashi scores in patients with MM and vertebral lesions. METHODS: Retrospective study on evaluation of radiographs and medical records of patients with MM using the criteria of Tomita and Tokuhashi. RESULTS: At 1 year 19 (63.3% were alive, 2 years 13 (43.3% and 5 years 4 (13.3% patients were alive. There was no correlation between the scores (Tomita and Tokuhashi and survival rate in these patients (p = 0.2255. CONCLUSION: There is a need for adjustment or alterations of the scores of Tomita and Tokuhashi to have applicability in patients with MM in column.

  17. Correlações genéticas de características de tamanho corporal e condição corporal com características de eficiência produtiva de fêmeas da raça Canchim Genetic correlations among cow body size, condition score and productive traits in Canchim cows

    Directory of Open Access Journals (Sweden)

    Fernando Baldi

    2008-03-01

    Full Text Available Os objetivos neste trabalho foram estimar a herdabilidade do número (NBZ10 e NBZT e quilogramas de bezerros desmamados (QBD10 e QBDT pela vaca até dez anos de idade e durante a permanência da fêmea no rebanho e de quilogramas de bezerros desmamados pela vaca por ano de permanência no rebanho (QTPR e as correlações genéticas dessas características com os pesos ajustados e não-ajustados para condição corporal, índice de tamanho corporal e condições corporais à primeira monta, ao primeiro parto e à idade adulta, idades ao primeiro, segundo e terceiro partos e tempo de permanência no rebanho. Os componentes de variância e de co-variância foram estimados pelo método da máxima verossimilhança restrita livre de derivadas, usando-se análises uni e bicaracterísticas. Os modelos estatísticos incluíram o efeito genético aditivo direto, como aleatório, e o efeito fixo de grupo de contemporâneos. As estimativas de herdabilidade obtidas das análises unicaracterísticas foram 0,10 ± 0,05 (NBZT, 0,10 ± 0,03 (QBDT, 0,12 ± 0,05 (NBZ10, 0,13 ± 0,05 (QBD10 e 0,15 ± 0,05 (QTPR, indicando que baixa resposta à seleção será obtida para essas características. A seleção para redução na idade ao primeiro parto não incrementará a produtividade das vacas. A seleção para aumentar o peso adulto das fêmeas acarretará redução em QTPR, NBZ10 e NBZT. A seleção para os índices de tamanho corporal ou para os pesos ajustados para condição corporal deve apresentar respostas correlacionadas com as características produtivas das fêmeas com tendências semelhantes, mas de maior magnitude que a seleção para peso da fêmea sem ajuste.The objectives of this study were to obtain heritability estimates for number (NBZ10 and NBZT and kilograms (QBD10 and QBDT of calves weaned up to ten years of age and during herd life, kilograms of calves weaned per year in herd (QTPR and their genetic correlations with culling age, ages at first, at second and at third calving, adjusted and unadjusted weights for condition score, body size indexes and condition score at first mating, at first calving and at mature age. Variance and covariance components were estimated by REML using univariate and bivariate models including the fixed effect of contemporary group and additive direct genetic and residual as random effects. Heritability estimates obtained from univariate analyses were 0.10 ± 0.05 (NBZT, 0.10 ± 0.03 (QBDT, 0.12 ± 0.05 (NBZ10, 0.13 ± 0.05 (QBD10 and 0.15 ± 0.05 (QTPR and indicate low response by selection on these traits. Genetic correlation estimate suggest that selection for reducing age at first calving will not improve cow productivity. Selection for increasing mature weight will reduce kilograms of calves weaned per year in herd and the number of calves weaned up to ten years of age and during herd life. Selection on body size indexes and on cow weights adjusted for condition score may result in similar correlated responses in productive traits of cows, which would be higher than those from selection on unadjusted cow weights.

  18. Correlações genéticas de características de tamanho corporal e condição corporal com características de eficiência produtiva de fêmeas da raça Canchim / Genetic correlations among cow body size, condition score and productive traits in Canchim cows

    Scientific Electronic Library Online (English)

    Fernando, Baldi; Mauricio Mello de, Alencar; Alfredo Ribeiro de, Freitas.

    2008-03-01

    Full Text Available Os objetivos neste trabalho foram estimar a herdabilidade do número (NBZ10 e NBZT) e quilogramas de bezerros desmamados (QBD10 e QBDT) pela vaca até dez anos de idade e durante a permanência da fêmea no rebanho e de quilogramas de bezerros desmamados pela vaca por ano de permanência no rebanho (QTPR [...] ) e as correlações genéticas dessas características com os pesos ajustados e não-ajustados para condição corporal, índice de tamanho corporal e condições corporais à primeira monta, ao primeiro parto e à idade adulta, idades ao primeiro, segundo e terceiro partos e tempo de permanência no rebanho. Os componentes de variância e de co-variância foram estimados pelo método da máxima verossimilhança restrita livre de derivadas, usando-se análises uni e bicaracterísticas. Os modelos estatísticos incluíram o efeito genético aditivo direto, como aleatório, e o efeito fixo de grupo de contemporâneos. As estimativas de herdabilidade obtidas das análises unicaracterísticas foram 0,10 ± 0,05 (NBZT), 0,10 ± 0,03 (QBDT), 0,12 ± 0,05 (NBZ10), 0,13 ± 0,05 (QBD10) e 0,15 ± 0,05 (QTPR), indicando que baixa resposta à seleção será obtida para essas características. A seleção para redução na idade ao primeiro parto não incrementará a produtividade das vacas. A seleção para aumentar o peso adulto das fêmeas acarretará redução em QTPR, NBZ10 e NBZT. A seleção para os índices de tamanho corporal ou para os pesos ajustados para condição corporal deve apresentar respostas correlacionadas com as características produtivas das fêmeas com tendências semelhantes, mas de maior magnitude que a seleção para peso da fêmea sem ajuste. Abstract in english The objectives of this study were to obtain heritability estimates for number (NBZ10 and NBZT) and kilograms (QBD10 and QBDT) of calves weaned up to ten years of age and during herd life, kilograms of calves weaned per year in herd (QTPR) and their genetic correlations with culling age, ages at firs [...] t, at second and at third calving, adjusted and unadjusted weights for condition score, body size indexes and condition score at first mating, at first calving and at mature age. Variance and covariance components were estimated by REML using univariate and bivariate models including the fixed effect of contemporary group and additive direct genetic and residual as random effects. Heritability estimates obtained from univariate analyses were 0.10 ± 0.05 (NBZT), 0.10 ± 0.03 (QBDT), 0.12 ± 0.05 (NBZ10), 0.13 ± 0.05 (QBD10) and 0.15 ± 0.05 (QTPR) and indicate low response by selection on these traits. Genetic correlation estimate suggest that selection for reducing age at first calving will not improve cow productivity. Selection for increasing mature weight will reduce kilograms of calves weaned per year in herd and the number of calves weaned up to ten years of age and during herd life. Selection on body size indexes and on cow weights adjusted for condition score may result in similar correlated responses in productive traits of cows, which would be higher than those from selection on unadjusted cow weights.

  19. Correlation Analysis of the quality of medical quality economic and financial management using correlation coefficients based on nonparametric data

    OpenAIRE

    Iacob, Constanta; Constantin, Camelia

    2014-01-01

    Starting from the idea that the use of multi-criteria analysis of performance within the hospital system allows a more accurate validation of employment, compared to the current methodology and seeking correlations between scores practiced economic efficiency and technical competence for all hospitals analyzed we see that there is a correlation between these values which suggests that hospital management's performance is a delusion because subordanarea different and multiple units of the heal...

  20. Analysis of Project Success Criteria in the Nigerian Construction Industry

    Directory of Open Access Journals (Sweden)

    Oluwaseun Sunday Dosumu

    2013-02-01

    Full Text Available This paper examined the relative importance of the project success criteria in the Nigerian construction industry. It also determined the correlation among the project success criteria. Based on the literatures reviewed, the study proposed a framework for measuring project success in the construction industry. The respondents for the study were the government, private clients, consultants and contractors. Three hundred copies of questionnaires were distributed to capture data on the subject, but only 86 were returned and used for the study. The paper captured respondents that are resident in Lagos state, Nigeria and chosen by convenience from selected organizations used for the study. The data were analysed with SPSS 16 through the use of frequencies, mean scores, factor analysis and correlation. Factor analysis was employed because the mean scores showed that all the project success criteria were at least important. Nine principal components were finally merged into 4 through the factor analysis using the Varimax rotation with Keiser normalization. The study found out that all the project success criteria were important but their level of importance differs according to the factor analysis carried out. Therefore, it was concluded that there are four major components of construction project success in Nigeria- user-related factors, professionals’ factors, organisational factors and other minor factors. The minor factors were found to be related to both organizations and projects but were not highly rated by respondents for determining construction project success. The study also concludes that project success criteria goes beyond meeting cost, time and quality target, it includes users’ satisfaction, professionals’ fulfilment and achievement of organizational goals. The recommendation of the study was that for construction projects to be successful, attention must be paid to users’ related factors, professionals’ factors and organizations’ factors.

  1. Observed Score Linear Equating with Covariates

    Science.gov (United States)

    Branberg, Kenny; Wiberg, Marie

    2011-01-01

    This paper examined observed score linear equating in two different data collection designs, the equivalent groups design and the nonequivalent groups design, when information from covariates (i.e., background variables correlated with the test scores) was included. The main purpose of the study was to examine the effect (i.e., bias, variance, and…

  2. Dual-energy X-ray absorptiometry diagnostic discordance between Z-scores and T-scores in young adults.

    LENUS (Irish Health Repository)

    Carey, John J

    2009-01-01

    Diagnostic criteria for postmenopausal osteoporosis using central dual-energy X-ray absorptiometry (DXA) T-scores have been widely accepted. The validity of these criteria for other populations, including premenopausal women and young men, has not been established. The International Society for Clinical Densitometry (ISCD) recommends using DXA Z-scores, not T-scores, for diagnosis in premenopausal women and men aged 20-49 yr, though studies supporting this position have not been published. We examined diagnostic agreement between DXA-generated T-scores and Z-scores in a cohort of men and women aged 20-49 yr, using 1994 World Health Organization and 2005 ISCD DXA criteria. Four thousand two hundred and seventy-five unique subjects were available for analysis. The agreement between DXA T-scores and Z-scores was moderate (Cohen\\'s kappa: 0.53-0.75). The use of Z-scores resulted in significantly fewer (McNemar\\'s p<0.001) subjects diagnosed with "osteopenia," "low bone mass for age," or "osteoporosis." Thirty-nine percent of Hologic (Hologic, Inc., Bedford, MA) subjects and 30% of Lunar (GE Lunar, GE Madison, WI) subjects diagnosed with "osteoporosis" by T-score were reclassified as either "normal" or "osteopenia" when their Z-score was used. Substitution of DXA Z-scores for T-scores results in significant diagnostic disagreement and significantly fewer persons being diagnosed with low bone mineral density.

  3. Correlation between the concentration of serum polychlorinated biphenyls (PCBs) in pregnant cynomolgus monkeys and their offspring's behavioral scores in eye-contact test and finger maze learning test

    Energy Technology Data Exchange (ETDEWEB)

    Negishi, T. [Aoyama Gakuin Univ., Kanagawa (Japan); Takasuga, T. [Shimadzu Techno-Research Inc., Kyoto (Japan); Kawasaki, K. [Hoshi Univ., Tokyo (Japan); Kuroda, Y. [CREST Japan Science and Technology Corp., Saitama (Japan); Yoshikawa, Y. [The Univ. of Tokyo (Japan)

    2004-09-15

    A recent review suggested that pre- or perinatal exposure of developing fetuses to dioxins, the widespread environmental contaminants, such as polychrorinated biphenlys (PCBs), induce the irreversible abnormalities in the functions of central nervous system (CNS) in human. These chemicals can be transferred to each fetus and naonate transplacentally and lactationally in rhesus monkey. Several studies also reported the adverse effect of PCB on CNS development in rodents and monkeys as well as on behavior in rodents and monkeys. In the present study, we show a preliminary data about the correlation between the serum concentrations of PCBs in pregnant cynomolgus monkeys (Macaca fascicularis) and the scores of two behavioral tests, eye-contact test and four-step finger maze test, which evaluate consciousness against human observer and learning ability, respectively, in their offspring. This experimental surveillance system using non-human primates would be useful to predict the risk of PCBs exposure in human fetuses because of the similarities of cynomolgus monkey to human with regard to reproduction, developmental parameter, and others.

  4. A comparative study of conservation and variation scores

    Directory of Open Access Journals (Sweden)

    Toh Hiroyuki

    2010-07-01

    Full Text Available Abstract Background Conservation and variation scores are used when evaluating sites in a multiple sequence alignment, in order to identify residues critical for structure or function. A variety of scores are available today but it is not clear how different scores relate to each other. Results We applied 25 conservation and variation scores to alignments from the Catalytic Site Atlas (CSA. We calculated distances among scores based on correlation coefficients, and constructed a dendrogram of the scores by average linking cluster analysis. The cluster analysis showed that most scores fall into one of two groups--substitution matrix based group and frequency based group respectively. We also evaluated the scores' performance in predicting catalytic sites and found that frequency based scores generally perform best. Conclusions Conservation and variation scores can be classified into mainly two large groups. When using a score to predict catalytic sites, frequency based scores that also consider a background distribution are most successful.

  5. Various criteria in the evaluation of biomedical named entity recognition

    Directory of Open Access Journals (Sweden)

    Lin Yu-Chun

    2006-02-01

    Full Text Available Abstract Background Text mining in the biomedical domain is receiving increasing attention. A key component of this process is named entity recognition (NER. Generally speaking, two annotated corpora, GENIA and GENETAG, are most frequently used for training and testing biomedical named entity recognition (Bio-NER systems. JNLPBA and BioCreAtIvE are two major Bio-NER tasks using these corpora. Both tasks take different approaches to corpus annotation and use different matching criteria to evaluate system performance. This paper details these differences and describes alternative criteria. We then examine the impact of different criteria and annotation schemes on system performance by retesting systems participated in the above two tasks. Results To analyze the difference between JNLPBA's and BioCreAtIvE's evaluation, we conduct Experiment 1 to evaluate the top four JNLPBA systems using BioCreAtIvE's classification scheme. We then compare them with the top four BioCreAtIvE systems. Among them, three systems participated in both tasks, and each has an F-score lower on JNLPBA than on BioCreAtIvE. In Experiment 2, we apply hypothesis testing and correlation coefficient to find alternatives to BioCreAtIvE's evaluation scheme. It shows that right-match and left-match criteria have no significant difference with BioCreAtIvE. In Experiment 3, we propose a customized relaxed-match criterion that uses right match and merges JNLPBA's five NE classes into two, which achieves an F-score of 81.5%. In Experiment 4, we evaluate a range of five matching criteria from loose to strict on the top JNLPBA system and examine the percentage of false negatives. Our experiment gives the relative change in precision, recall and F-score as matching criteria are relaxed. Conclusion In many applications, biomedical NEs could have several acceptable tags, which might just differ in their left or right boundaries. However, most corpora annotate only one of them. In our experiment, we found that right match and left match can be appropriate alternatives to JNLPBA and BioCreAtIvE's matching criteria. In addition, our relaxed-match criterion demonstrates that users can define their own relaxed criteria that correspond more realistically to their application requirements.

  6. What Is the Apgar Score?

    Science.gov (United States)

    ... Safe Concussions: What to Know What Is the Apgar Score? KidsHealth > Parents > Pregnancy & Newborn Center > Q&As > ... Apgar Score What Apgar Scores Mean About the Apgar Score The Apgar score, the very first test ...

  7. Skin scoring in systemic sclerosis

    DEFF Research Database (Denmark)

    Zachariae, Hugh; Bjerring, Peter; Halkier-Sørensen, Lars; Heickendorff, Lene; Søndergaard, Klaus

    1994-01-01

    Forty-one patients with systemic sclerosis were investigated with a new and simple skin score method measuring the degree of thickening and pliability in seven regions together with area involvement in each region. The highest values were, as expected, found in diffuse cutaneous systemic sclerosis (type III SS) and the lowest in limited cutaneous systemic sclerosis (type I SS) with no lesions extending above wrists and ancles. A positive correlation was found to the aminoterminal propeptide of t...

  8. 7 CFR 1703.126 - Criteria for scoring grant applications.

    Science.gov (United States)

    2010-01-01

    ...RURAL UTILITIES SERVICE, DEPARTMENT... Distance Learning and Telemedicine...The need for services and benefits derived from...or medical services which are needed...provide direct benefits to rural residents...lifetime learning,...

  9. 7 CFR 1703.126 - Criteria for scoring grant applications.

    Science.gov (United States)

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Grant Program... opportunities for a specified number of students; (2) Travel time and money saved by telemedicine diagnoses; (3... training; (8) Number of patients receiving telemedicine diagnoses; (9) Provision of training,...

  10. Prediction of bronchopulmonary dysplasia by chest radiographic scoring system at seven days of age

    International Nuclear Information System (INIS)

    Recent trials of preventive dexamethasone therapy in preterm neonates at high risk of developing bronchopulmonary dysplasia (BPD) have required the objective criteria for prediction of BPD in the early neonatal period. The purpose of this study is to determine whether a chest radiographic scoring system at 7 days of age can be used to predict BPD. Chest radiographs taken at 7 days and 28 days of age in 59 preterm neonates(gestational age of less than 33 weeks) were scored prospectively according to the consensus of two radiologists. The 7-day radiographs were scored according to a system derived from Yuksel's method:endotracheal tube insertion, degree of lung inflation, lung opacification, interstitial changes and cardiomegaly were measured. The radiographs taken at 28 days were scored according to a modification of Toce's method. The BPD group was defined as consisting of patients who needed oxygen therapy for more than 28 days and showed abnormality on chest radiographs. Scores were analysed to determine whether there were any statistical differences between the BPD and non-BPD groups, whether there was a significant correlation between scores at 7 days and 28 days, and whether there was any relationship between scores at 7 days of age and the development of BPD. We tried to determine which factors, as indicated by the scores at 7 days, significantly contributed to the development of BPD. The mean scores at 7 days of age in the BPD group (n=18) were 4.3±1.5 (2-7), and those in the non-BPD group (n=41) were 2.2±1.2 (0-4). The differences were statistically significant (p<.0001). Significant correlation was found between scores at 7 days and at 28 days of age(r:0.57, p<.0001). Analysis showed that endotracheal tube insertion, cardiomegaly, and degree of interstitial change, as seen on radiographs at 7 days, were factors which significantly contributed to the development of BPD (p<0.05 each). All neonates with a score of 5 or more developed BPD (7/7), while those with a score of less than 2 did not (0/11). The chest radiographic scoring system used at 7 days of age can be helpful in predicting the development of BPD. We believe that this system can be used to indicate the need for early preventive steroid therapy

  11. Relationship between hand-skill exercises and other admissions criteria and students' performance in dental school.

    Science.gov (United States)

    Ballard, Richard W; Hagan, Joseph L; Cheramie, Toby

    2015-05-01

    The aim of this study was to investigate the existence of correlations between dental admissions criteria, including a chalk carving exercise, and students' subsequent academic performance. The retrospective cohort study examined the records of dental students at Louisiana State University Health Science Center School of Dentistry for the years 1998 to 2008. Only those students who could be categorized into the following four groups were included: 1) those who graduated in the top 10% of their class, 2) those who graduated in the bottom 10% of their class, 3) those who repeated a year of dental school, and 4) those who were dismissed or resigned. The study sample consisted of 176 students: 62 in the first group, 62 in the second group, 25 in the third group, and 27 in the fourth group. Data collected were each student's undergraduate grade point average (GPA); chalk carving score; undergraduate biology, chemistry, physics (BCP) GPA; Dental Admission Test (DAT) Academic Average; Perceptual Ability Test (PAT) score of the DAT; total DAT score; grade in preclinical operative dentistry class; grade in morphology and occlusion class; and dental school GPA at graduation. The results showed that only the undergraduate GPA and BCP GPA were significantly higher for students in the top 10% of their class than for other groups. The only positive correlation involving the chalk carving scores was with the preclinical operative dentistry course grade. This study thus found limited correlations between this institution's admissions criteria and its students' success in dental school. PMID:25941149

  12. Genetic evaluation of elbow scores and the relationship with hip scores in UK Labrador retrievers.

    Science.gov (United States)

    Lewis, T W; Ilska, J J; Blott, S C; Woolliams, J A

    2011-08-01

    A linear mixed model analysis of elbow and hip score data from UK Labrador retrievers was used to estimate the heritability of elbow score (0.16-0.19) and to determine a moderate and beneficial genetic correlation with hip score (0.40). A small improvement in the genetic trend of elbow score was observed during the years 2000-2008, equivalent to avoiding only the worst 3-4% of scored dogs for breeding, but close to what may have been anticipated if the current British Veterinary Association-approved guidelines were followed. Calculations suggested that a correlated response to indirect selection on hip score may elicit a greater response than direct selection on elbow score and that the genetic trend in elbow score may be explained as a consequence of the stronger selection pressure that has been placed on hip score. Increases in the accuracy of estimated breeding values for elbow score of 4-7% for dogs with elbow data only and 7-11% for dogs with both hip and elbow score were observed from bivariate analysis of elbow and hip data. A selection index confirmed the benefits of bivariate analysis of elbow and hip score data by identifying increases in accuracy (directly related to the response to selection) of 14% from the use of optimum coefficients compared to use of hip data only. The quantified genetic correlation means that hip score effectively acts as a 'secondary indicator' of elbow score in this breed and the preponderance of hip data means that it acts as a major source of information that may be used to improve the accuracy of estimates of genetic risk for elbow dysplasia. PMID:21737324

  13. Scoring Play Combinatorial Games

    OpenAIRE

    Stewart, Fraser

    2012-01-01

    This thesis will be discussing scoring play combinatorial games and looking at the general structure of these games under different operators. I will also be looking at the Sprague-Grundy values for scoring play impartial games, and demonstrating that there is an easily computable function that will solve a large range of octal games easily. I will also be demonstrating that my theory can readily be applied to the scoring play game of Go and can lead to a much greater unders...

  14. The Bandim tuberculosis score

    DEFF Research Database (Denmark)

    Rudolf, Frauke; Joaquim, Luis Carlos; Vieira, Cesaltina; Andersen, Morten Bjerregaard; Andersen, Andreas; Erlandsen, Mogens; Sodemann, Morten; Andersen, Paul Lehm; Wejse, Christian

    2013-01-01

    Background: This study was carried out in Guinea-Bissau's capital Bissau among inpatients and outpatients attending for tuberculosis (TB) treatment within the study area of the Bandim Health Project, a Health and Demographic Surveillance Site. Our aim was to assess the variability between 2 physicians in performing the Bandim tuberculosis score (TBscore), a clinical severity score for pulmonary TB (PTB), and to compare it to the Karnofsky performance score (KPS). Method: From December 2008 to Ju...

  15. Interpreting force concept inventory scores: Normalized gain and SAT scores

    Directory of Open Access Journals (Sweden)

    Jeffrey J. Steinert

    2007-05-01

    Full Text Available Preinstruction SAT scores and normalized gains (G on the force concept inventory (FCI were examined for individual students in interactive engagement (IE courses in introductory mechanics at one high school (N=335 and one university (N=292 , and strong, positive correlations were found for both populations ( r=0.57 and r=0.46 , respectively. These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawson’s Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of students’ cognitive skills, as measured either by the SAT or by Lawson’s test. While Lawson’s test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of students’ reasoning abilities. Knowing the students’ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve students’ cognitive level.

  16. Comparison of Prognosis in Patients with Liver Cirrhosis and its Correlation with the Model for the End-Stage Liver Disease and Child-PughChild-Pugh Scores in Patients with Esophageal or Gastric Variceal Bleeding

    Directory of Open Access Journals (Sweden)

    Mohammadreza Sheikhian

    2013-09-01

    Full Text Available Background:Variceal bleeding is one of the most serious complications of cirrhosis. Up to now different methods are created for predicting the complications and mortality of cirrhosis. Child- Pugh score and MELD score are two methods for this use. In this study we investigated and compared survival prognosis of cirrhotic patients by the Child-Pugh or MELD score in two groups of esophageal and gastric variceal bleeding. Materials and Methods: In this cross-sectional trial, patients with upper GI bleeding were followed up for a 6 months period. The source of hemorrhage was determined by endoscopy, then patients distributed in two groups of esophageal and gastric variceal hemorrhage. Finally we investigated and compared the relationship between the variables and mortality rates in these two groups by means of the Child-Pugh and the MELD scores. The Student’s t-test and Receiver Operating Characteristic were used for statistical analysis.Results: 34 patients (12 with gastric varices, 22 with esophageal varices were investigated. No significant difference between these two groups was observed. In this study mean MELD score was 16.67±8.75 and mean Child-Pugh score was 9.37±2.54. Eight patients (5 with gastric varices and 3 with esophageal varices expired before 6 weeks and 2 patients (one four each group expired after 6 weeks. The best cut-off points are 15.5 and 10.5 for MELD and Child-Pugh scores respectively (sensitivity and specificity are 0.75 and 0.98, respectively for both scores.Conclusion:Sensitivity and specificity of both scores were the same in prediction of mortality. However, the chance ratio defined that Child-Pugh score was a better predictor of mortality than MELD score, since the chance of death will increase 2.51 and 1.62 fold per each unit increase in the Child-Pugh and the MELD scores, respectively. However, no significant difference found between Child-Pugh and MELD score between two groups of patients.

  17. Evaluation of a nutrient-rich food index score in the Netherlands.

    Science.gov (United States)

    Sluik, Diewertje; Streppel, Martinette T; van Lee, Linde; Geelen, Anouk; Feskens, Edith J M

    2015-01-01

    Nutrient-rich food (NRF) index scores are dietary quality indices based on nutrient density. We studied the design aspects involved in the development and validation of NRF index scores, using the Dutch consumption data and guidelines as an example. We evaluated fifteen NRF index scores against the Dutch Healthy Diet Index (DHD-index), a measure of adherence to the Dutch dietary guidelines, and against energy density. The study population included 2106 adults from the Dutch National Food Consumption Survey 2007-2010. The index scores were composed of beneficial nutrients (protein, fibre, fatty acids, vitamins, minerals), nutrients to limit (saturated fat, sugar, Na) or a combination. Moreover, the influence of methodological decisions was studied, such as the choice of calculation basis (100 g or 100 kcal (418 kJ)). No large differences existed in the prediction of the DHD-index by the fifteen NRF index scores. The score that best predicted the DHD-index included nine beneficial nutrients and three nutrients to limit on a 100-kcal basis, the NRF9.3 with a model R (2) of 0·34. The scores were quite robust with respect to sex, BMI and differences in calculation methods. The NRF index scores were correlated with energy density, but nutrient density better predicted the DHD-index than energy density. Consumption of vegetables, cereals and cereal products, and dairy products contributed most to the individual NRF9.3 scores. In conclusion, many methodological considerations underlie the development and evaluation of nutrient density models. These decisions may depend upon the purpose of the model, but should always be based upon scientific, objective and transparent criteria. PMID:26097700

  18. La evaluación de revistas de psicología: correlación entre el factor de impacto, el índice h y los criterios de Latindex / Assessment of psychology journals: correlation of impact factor and h-index vs. Latindex criteria

    Scientific Electronic Library Online (English)

    A. Matías, Gámez.

    2013-12-01

    Full Text Available El objetivo de este trabajo fue comprobar el grado en que dos criterios basados en el recuento de citas, como el factor de impacto propuesto por el Journal Citation Reports y el índice h de Hirsch (2005), y otro criterio más relacionado con la calidad del proceso editorial, como el grado de cumplimi [...] ento de los criterios propuestos por el catálogo Latindex, ordenan de forma similar un conjunto de revistas de psicología. Utilizamos estos tres criterios para confeccionar sendas clasificaciones de estas revistas y encontramos que la correlación entre la clasificación Latindex y cualquiera de las otras dos no fue significativamente distinta de cero. Se discute la conveniencia de disponer de criterios ajenos al recuento de citas para evaluar la calidad de las revistas científicas de psicología y se propone el uso combinado de criterios como la difusión, la internacionalidad, el proceso de revisón de los manuscritos o la política editorial de la revista. Abstract in english The goal of this study is to explore the extent to which several psychology journals may be similarly classified on the basis of citation count through the impact factor proposed by Journal Citation Reports and the hindex (Hirsch, 2005), against a given journal's compliance with the Latindex Catalog [...] ue criteria for assessing editorial quality. Using these parameters, we carried out three separate journal rankings and found that the correlation between the Latindex ranking and either of the former is not statistically distinct from zero. The suitability of applying editorial- rather than citation-based criteria to evaluate the quality of psychology journals is discussed. This discussion proposes using a mix of editorial criteria such as circulation, international reach and the journal's manuscript review process and editorial policies.

  19. Satisfaction in hospitality on TripAdvisor.com: An analysis of the correlation between evaluation criteria and overall satisfaction / A satisfação na hotelaria pelo TripAdvisor: uma análise da correlação entre os critérios de avaliação e satisfação geral

    Scientific Electronic Library Online (English)

    Pablo Flôres, Limberger; Francisco Antonio dos, Anjos; Jéssica Vieira de Souza, Meira; Sara Joana Gadotti dos, Anjos.

    2014-01-01

    Full Text Available As mídias sociais alteraram a forma dos turistas buscarem e trocarem informações, determinando mudanças gerenciais para as empresas turísticas, incluindo os meios de hospedagem. Os comentários e avaliações de hóspedes têm impactado na reputação das organizações, tanto positivamente como negativament [...] e. Os sítios de conteúdo gerado pelos usuários permitem que estas informações cheguem a outros turistas, através da avaliação do serviço prestado e influenciando na decisão de novos visitantes. Desta forma, esta investigação procurou identificar a correlação entre a satisfação geral e os critérios de avaliação. Para isto, foram analisadas 660 avaliações (236 nos hotéis 03 estrelas, 125 nos hotéis 04 estrelas e 299 nos hotéis 05 estrelas) no Tripadvisor, que continham de forma independente, avaliações sobre: satisfação geral, valor (custo-benefício), localização, qualidade do sono, quartos, limpeza e serviço. Os resultados apontaram para um maior índice de correlação da satisfação geral com os critérios quarto, serviço ofertado e custo-benefício. Abstract in english Social media has changed the way tourists seek and exchange information, resulting in changes in the management of tourism businesses including hospitality facilities. Guest reviews and comments have had an impact on the reputation of organisations, both positive and negative. Websites with user-gen [...] erated content spread this information to other tourists through the evaluation of service provided and thereby influence the decision of new visitors. Accordingly, this research sought to identify the correlation between overall satisfaction and the evaluation criteria used on a website. For this, we analysed 660 reviews (236 of three-star hotels, 125 of four-star hotels and 299 of five-star hotels) on TripAdvisor, containing independent reviews including overall satisfaction, value (cost-benefit), location, sleep quality, rooms, cleanliness and service. Results showed a strong correlation of overall satisfaction with the criteria of room, service provided and cost-benefit.

  20. Shrinkage Estimation of Linear Combinations of True Scores.

    Science.gov (United States)

    Longford, Nicholas T.

    1997-01-01

    It is demonstrated that, in the presence of population information, a linear combination of true scores can be estimated more efficiently than by the same linear combination of the observed scores. Three criteria for optimality are discussed, but they yield the same solution, described as a multivariate shrinkage estimator. (Author/SLD)

  1. How Holistic Scoring Kept Writing Alive in Chemistry.

    Science.gov (United States)

    Rodgers, M. L.

    1995-01-01

    Development and implementation of a holistic method for scoring writing assignments in a college general education chemistry course are described. The system included assessment of discrete elements in the paper's focus, appearance, content, and structure according to specific criteria. The approach saved considerable scoring time and enhanced…

  2. Resin selection criteria for tough composite structures

    Science.gov (United States)

    Chamis, C. C.; Smith, G. T.

    1983-01-01

    Resin selection criteria are derived using a structured methodology consisting of an upward integrated mechanistic theory and its inverse (top-down structured theory). These criteria are expressed in a "criteria selection space" which are used to identify resin bulk properties for improved composite "toughness". The resin selection criteria correlate with a variety of experimental data including laminate strength, elevated temperature effects and impact resistance.

  3. Decisions during courtship by male and female medflies (Diptera, Tephritidae): Correlated changes in male behavior and female acceptance criteria in mass-reared flies

    International Nuclear Information System (INIS)

    Analyses of more than 300 videotaped courtships of wild and mass-reared medflies from Costa Rica showed that the tendency for male and female to align themselves facing directly toward each other increased, and that the distance between them decreased as courtship proceeded. More direct alignments and shorter distances between the flies at the moment the male jumped onto the female were correlated with greater female acceptance of copulation. There were no consistent differences in durations of components of intermittent buzzing songs or male size between successful and unsuccessful courtship in either strain. Several possible cues may release different courtship responses: males of both strains tend to initiate both continuous vibration and intermittent buzzing after reduction of the distance to the female; slow creeping toward the female was associated with longer courtships that had failed to lure the female close; and females tended to turn to face more directly toward the male soon after the male began continuous vibration, and especially after he began intermittent buzzing. Females became progressively more immobile as courtship progressed, especially soon after intermittent buzzing began. There were numerous differences between strains. Mass-reared males were more likely to mount females without previous courtship than were wild males. Wild males initiated continuous wing vibration when farther from the female and when the female was looking less directly toward them, but the two strains did not differ in the distances and angles at which males initiated intermittent buzzing and jumped. Wild males were more likely to creep toward the female during intermittent buzzing. Mass-reared females but not wild females were more likely to copulate when the proportion of time the male had spent in intermittent buzzing was low, and if the courtship began when the flies were nearer each other. Wild but not mass-reared females were less likely to copulate if courtship was shorter. Possible co-evolution of female responses with the five different male courtship traits that differ between mass-reared and wild flies are discussed. (author)

  4. The Bandim tuberculosis score

    DEFF Research Database (Denmark)

    Rudolf, Frauke; Joaquim, Luis Carlos; Vieira, Cesaltina; Bjerregaard-Andersen, Morten; Andersen, Andreas; Erlandsen, Mogens; Sodemann, Morten; Andersen, Paul Lehm; Wejse, Christian

    2012-01-01

    Background: This study was carried out in Guinea-Bissau's capital Bissau among inpatients and outpatients attending for tuberculosis (TB) treatment within the study area of the Bandim Health Project, a Health and Demographic Surveillance Site. Our aim was to assess the variability between 2...... physicians in performing the Bandim tuberculosis score (TBscore), a clinical severity score for pulmonary TB (PTB), and to compare it to the Karnofsky performance score (KPS). Method: From December 2008 to July 2009 we assessed the TBscore and the KPS of 100 PTB patients at inclusion in the TB cohort and...

  5. The Bandim tuberculosis score

    DEFF Research Database (Denmark)

    Rudolf, Frauke; Joaquim, Luis Carlos; Vieira, Cesaltina; Andersen, Morten Bjerregaard; Andersen, Andreas; Erlandsen, Mogens; Sodemann, Morten; Andersen, Paul Lehm; Wejse, Christian

    2013-01-01

    Background: This study was carried out in Guinea-Bissau's capital Bissau among inpatients and outpatients attending for tuberculosis (TB) treatment within the study area of the Bandim Health Project, a Health and Demographic Surveillance Site. Our aim was to assess the variability between 2...... physicians in performing the Bandim tuberculosis score (TBscore), a clinical severity score for pulmonary TB (PTB), and to compare it to the Karnofsky performance score (KPS). Method: From December 2008 to July 2009 we assessed the TBscore and the KPS of 100 PTB patients at inclusion in the TB cohort and...

  6. Scoring Play Combinatorial Games

    CERN Document Server

    Stewart, Fraser

    2012-01-01

    This thesis will be discussing scoring play combinatorial games and looking at the general structure of these games under different operators. I will also be looking at the Sprague-Grundy values for scoring play impartial games, and demonstrating that there is an easily computable function that will solve a large range of octal games easily. I will also be demonstrating that my theory can readily be applied to the scoring play game of Go and can lead to a much greater understanding of the game.

  7. Automated scoring of CDMAM: a dose study

    Science.gov (United States)

    Rico, Ruben; Muller, Serge L.; Peter, Guillaume; Noel, Alain; Stines, Joseph

    2003-05-01

    Digital mammography detectors have a large linear dynamic range that allows dose optimization. CD-MAM phantom is widely used in image quality assessment on mammography systems. Currently human readers score the phantom, which is time-consuming and leads to intra and inter observer variability. We discuss the design and validation of an algorithm based on the Non-Prewhitening Matched Filter observer that intends to replace human observers in the task of CDMAM 3.4 phantom scoring. Correlation between both observers has been evaluated through a dose study. Correlation has been established between scores obtained by both observers. The algorithm presents a higher sensitivity and a better discrimination power to dose variations, which makes automated scoring of CDMAM phantom a potential tool, free of observer variability, for quality control in screening mammography.

  8. Volleyball Scoring Systems.

    Science.gov (United States)

    Calhoun, William; Dargahi-Noubary, G. R.; Shi, Yixun

    2002-01-01

    The widespread interest in sports in our culture provides an excellent opportunity to catch students' attention in mathematics and statistics classes. One mathematically interesting aspect of volleyball, which can be used to motivate students, is the scoring system. (MM)

  9. Scoring Play Combinatorial Games

    CERN Document Server

    Stewart, Fraser

    2012-01-01

    In this paper we will discuss scoring play games. We will give the basic definitions for scoring play games, and show that they form a well defined set, with clear and distinct outcome classes under these definitions. We will also show that under the disjunctive sum these games form a semi-group that is closed, partially ordered with distinct equivalence classes that have a unique representative or canonical form.

  10. Impartial Scoring Play Games

    CERN Document Server

    Stewart, Fraser

    2012-01-01

    In this paper we will be examining impartial scoring play games. We first give the basic definitions for what impartial scoring play games are and look at their general structure under the disjunctive sum. We will then examine the game of nim and all octal games, and define a function that can help us analyse these games. We will finish by looking at the properties this function has and give many conjectures about the behaviour this function exhibits.

  11. Neurogenic bowel dysfunction score

    DEFF Research Database (Denmark)

    Krogh, Klaus; Christensen, Peter; Sabroe, S; Laurberg, S

    2005-01-01

    STUDY DESIGN: Cross-sectional questionnaire study. OBJECTIVES: To develop and validate a symptom-based score for neurogenic bowel dysfunction (NBD): NBD score. SETTING: University Hospital of Aarhus, Denmark. METHODS: A questionnaire including questions about background parameters (n=8), faecal incontinence (n=10), constipation (n=10), obstructed defecation (n=8), and impact on quality of life (QOL) (n=3) was sent to 589 Danish spinal cord injured (SCI) patients. The reproducibility and validity...

  12. Automated Essay Scoring

    OpenAIRE

    DIKLI, Semire

    2006-01-01

    Automated Essay Scoring Semire DIKLI Florida State University Tallahassee, FL, USA ABSTRACT The impacts of computers on writing have been widely studied for three decades. Even basic computers functions, i.e. word processing, have been of great assistance to writers in modifying their essays. The research on Automated Essay Scoring (AES) has revealed that computers have the capacity to function as a more effective cognitive tool (Attali, 2004). AES is defined a...

  13. Scoring Models in Finance

    OpenAIRE

    Rychnovský, Michal

    2011-01-01

    The aim of the present work is to describe the application of the logistic regression model to the field of probability of default modeling, and provide a brief introduction to the scoring development process used in financial practice. We start by introducing the theoretical background of the logistic regression model; followed by a consequent derivation of three most common scoring models. Then we present a formal definition of the Gini coefficient as a diversification power measure and der...

  14. Malnutrition-Inflammation Score in Hemodialysis Patients

    Directory of Open Access Journals (Sweden)

    Behrooz Ebrahimzadehkor

    2014-08-01

    Full Text Available Background: Malnutrition is a prevalent complication in patients on maintenance hemodialysis. Malnutrition-inflammation score (MIS, comprehensive nutritional assessment tool, as the reference standard was used to examine protein-energy wasting (PEW and inflammation in hemodialysis patients. Materials and Methods: In this descriptive- analytical study, 48 hemodialysis patients were selected with random sampling. All the patients were interviewed and the MIS of the patients was recorded. This new comprehensive Malnutrition-Inflammation Score (MIS which involves 7 components from the SGA and the 3 additional non-SGA components of body mass index, serum albumin, and total iron-binding capacity (TIBC has 10 components, each with four levels of severity, from 0 (normal to 3 (very severe. These scores were compared with anthropometric measurements; laboratory measures. Data was analyzed with Chi-square and t-tests and Pearson correlation coefficiant. Results: In this study 25% of patients on hemodialysis were normal nourished, 54.3% of patients were mild malnourished, 20.8% were moderately malnourished and no one of them were not sever malnurished. Pearson correlation coefficients between MIS score and age (r=+0.332 was significant. There was no correlation between the malnutrition score and sex Chi-square test showed significant correlation between MIS score and dialysis period ?50 months (?²=9.09. Conclusion: In this study, no one of patients has severed malnutrition, and most of them were assigned to the mildly/moderately malnourished rating. On other hand, most of patients are the well-nourished. Correlation between MIS score and age and dialysis period was significant.

  15. Genetic effect on apgar score

    Directory of Open Access Journals (Sweden)

    Carla Franchi-Pinto

    1999-03-01

    Full Text Available Intraclass correlation coefficients for one- and five-min Apgar scores of 604 twin pairs born at a southeastern Brazilian hospital were calculated, after adjusting these scores for gestational age and sex. The data support a genetic hypothesis only for 1-min Apgar score, probably because it is less affected by the environment than 4 min later, after the newborns have been under the care of a neonatology team. First-born twins exhibited, on average, better clinical conditions than second-born twins. The former showed a significantly lower proportion of Apgar scores under seven than second-born twins, both at 1 min (17.5% vs. 29.8% and at 5 min (7.2% vs. 11.9%. The proportion of children born with "good" Apgar scores was significantly smaller among twins than among 1,522 singletons born at the same hospital. Among the latter, 1- and 5-min Apgar scores under seven were exhibited by 9.2% and 3.4% newborns, respectively.Os coeficientes de correlação intraclasse foram calculados para os índices de Apgar 1 e 5 minutos após o nascimento de 604 pares de gêmeos em uma maternidade do sudeste brasileiro, depois que esses índices foram ajustados para idade gestacional e sexo. Os dados obtidos apoiaram a hipótese genética apenas em relação ao primeiro índice de Apgar, provavelmente porque ele é menos influenciado pelo ambiente do que 4 minutos depois, quando os recém-nascidos já estiveram sob os cuidados de uma equipe de neonatologistas. Os gêmeos nascidos em primeiro lugar apresentaram, em média, melhor estado clínico que os nascidos em segundo lugar, visto que os primeiros mostraram uma proporção de índices de Apgar inferiores a 7 significativamente menor do que os nascidos em segundo lugar, tanto um minuto (17,5% contra 29,8% quanto cinco minutos após o nascimento (7,2% contra 11,9%. A proporção de recém-nascidos com índices de Apgar que indicam bom prognóstico foi significativamente menor nos gêmeos do que em 1.522 conceptos únicos nascidos na mesma maternidade. Índices de Apgar menores do que 7, obtidos um e cinco minutos após o nascimento, foram encontrados respectivamente em 9,2% e em 3,4% dos recém-nascidos de parto único.

  16. Correlation between Teacher Turnover Rates in the State of Alaska and Standardized Test Scores in the Area of Mathematics on the Standards Based Assessments/High School Qualifying Exam

    Science.gov (United States)

    Roehl, Roy F., II

    2010-01-01

    This study utilized bivariate correlations, partial correlations, multivariate analysis including Hotelling-T, and observed power to investigate the possible correlations and connections of teacher turnover in Alaska's public school system to performance on the standards-based assessment of the Alaska High School Qualifying Exam (HSQE). The study…

  17. Correlación entre las buenas prácticas de manufactura y el cumplimiento de los criterios microbiológicos en la fabricación de helados en Chile / Correlation between the good manufacturing practices and compliance with microbiological criteria in the manufacture of ice cream in Chile

    Scientific Electronic Library Online (English)

    José Miguel, Bastías M; Marcela, Cuadra H; Ociel, Muñoz F; Roberto, Quevedo L.

    2013-06-01

    Full Text Available Las Buenas Prácticas de Manufacturas (BPM) son una herramienta básica para obtener un producto alimenticio seguro para consumo humano. El objetivo de este estudio fue determinar el porcentaje de cumplimiento de BPM y su correlación con la aceptación de criterios microbiológicos en fábricas y muestra [...] s de helados de Ñuble, Chile, de acuerdo al Reglamento Sanitario de Alimentos chilenos. Se analizaron auditorías de BPM aplicadas por fiscalizadores de Secretaría Regional Ministerial (SEREMI) de Salud Ñuble, a 40 fábricas de helados y los resultados microbiológicos de 435 muestras de helados entre los años 2005 y 2010. Se determinó que el 55,2% de las muestras no cumplieron para RAM (105 UFC/g) y coliformes (102 UFC/g) y 4,6% para Staphylococcus aureus (102 UFC/g), en cambio el 100% cumplieron para Salmonella spp. Los mayores RAM fueron en verano con 60% de rechazo. El 67% de auditorías de BPM alcanzaron valores superiores al mínimo (70% de cumplimiento), las instalaciones fue el ítem mejor evaluado (88,4%), y capacitación del personal el peor (20,3 %). La correlación entre los resultados de auditorías de BPM y criterios microbiológicos permitió comprobar que con un porcentaje igual o superior al 80% de cumplimiento de BPM se aseguraría la calidad microbiológica de helados, disminuyendo con ello el riesgo en la salud del consumidor. Abstract in english The Good Manufacturing Practices (GMP) is a basic tool to obtain safe foodstuffs for human consumption. The main goal of this research was to determine the percentage of compliance with GMP in ice cream factories and its correlation with the acceptance of microbiological criteria in samples of ice c [...] ream, according to the Sanitary Chilean Food Regulation. Inspectors from the Ministerial Regional Secretariat (SEREMI) of Health Ñuble audited GMP in 40 ice cream factories and 435 microbial analyses from ice cream samples taken between the years 2005 and 2010 were analyzed. Results showed that 55.2% of samples failed in RAM (105 UFC/g) and coliform (102 UFC/g) and 4.6% for Staphylococcus aureus (102 UFC/g) and 100% for Salmonella spp. The biggest RAM was during summer with 60% rejection. Sixty seven% of inspections of GMP reached values above the minimum (70% compliance). Facilities were the best item assessed (88.4%), and training was the worst (20.3%). The correlation between the results of audits of GMP and microbiological criteria allowed proving that with a percentage equal to or greater than 80% compliance with GMP would ensure the microbiological quality of ice cream, thereby decreasing the risk for consumer health.

  18. Ki-67 expression score correlates to survival rate in gastrointestinal stromal tumors (GIST Escore de expressão de Ki-67 correlaciona-se com taxa de sobrevida em tumores estromais gastrointestinais (GIST

    Directory of Open Access Journals (Sweden)

    Ricardo Artigiani Neto

    2012-05-01

    Full Text Available PURPOSE: To evaluate the immunohistochemical expression of p16, Ki-67, p53 and Bcl-2 proteins in gastrointestinal stromal tumors (GIST; to assess the possible association between these variables and clinical and histopathological factors of cancer; and to check for prognostic value of these variables (survival and recurrence. METHODS: A sample of 55 patients treated surgically for GIST in three hospitals was studied. The surgically excised tumors were confirmed as GIST by KIT, vimentin, desmin S100 protein, CD117, 1A4 and CD34 assessment in paraffin blocks. RESULTS: Only 9 (16% cases of GIST were positive for p53, p16 was positive among 43.6%; 80% of GISTs showed staining for Bcl-2. The proliferative index (expressed as the proportion of positive cells assessed by immunohistochemical expression of Ki-67 was high in 49% of cases. Elevated Ki-67 scores were associated to high histological grade (p=0.0026 and mitosis index, MI (p=0.0001. High Ki-67 index was associated to death. Expression of p53, p16 and Bcl-2 did not correlate to morphological or clinical variables. CONCLUSIONS: Ki-67 immunohistochemical evaluation should be included in preoperative evaluation of GIST biopsies or surgical specimens as a prognostic tool for clinical staging; and all other proteins studied (Bcl-2, p53 and p16 did not play a role in GIST metabolic or carcinogenic process, remaining without prognostic value.OBJETIVO: Avaliar a expressão imunoistoquímica de p16, Ki-67, p53 e Bcl-2 proteínas em tumores gastrointestinais estromais (GIST; determinar a possível associação entre essas variáveis e fatores clínicos e histopatológicos de câncer, e para verificar o valor prognóstico destas variáveis (sobrevivência e recorrência. MÉTODOS: Uma amostra de 55 pacientes tratados cirurgicamente para GIST em três hospitais foi estudada. Os tumores extirpados cirurgicamente foram confirmados como GIST por KIT, vimentina, proteína desmina S100, CD117, 1A4 e avaliação de CD34 em blocos de parafina. RESULTADOS: Apenas nove (16% casos de GIST foram positivos para p53, p16 foi positiva em 43,6%, 80% dos GIST apresentaram coloração para Bcl-2. O índice proliferativo (expresso como a proporção de células positivas, avaliado pela expressão imunoistoquímica de Ki-67, foi elevado em 49% dos casos. Escores de Ki-67 elevados foram associados com alto grau histológico (p=0,0026 e índice de mitose, MI (p=0,0001. Alto índice de Ki-67 foi associado à morte. Expressão da p53, p16 e Bcl-2 não se correlacionou com as variáveis morfológicas ou clínicas. CONCLUSÕES: A avaliação imunoistoquímica de Ki-67 deve ser incluída na avaliação pré-operatória de biópsias ou peças cirúrgicas de GIST como uma ferramenta prognóstica para o estadiamento clínico, e todas as outras proteínas estudadas (Bcl-2, p53 e p16 não desempenharam um papel no processo metabólico ou carcinogênico em GIST, mantendo-se sem valor prognóstico.

  19. Ki-67 expression score correlates to survival rate in gastrointestinal stromal tumors (GIST) / Escore de expressão de Ki-67 correlaciona-se com taxa de sobrevida em tumores estromais gastrointestinais (GIST)

    Scientific Electronic Library Online (English)

    Ricardo, Artigiani Neto; Angela Flavia, Logullo; João Norberto, Stávale; Laércio Gomes, Lourenço.

    2012-05-01

    Full Text Available OBJETIVO: Avaliar a expressão imunoistoquímica de p16, Ki-67, p53 e Bcl-2 proteínas em tumores gastrointestinais estromais (GIST); determinar a possível associação entre essas variáveis e fatores clínicos e histopatológicos de câncer, e para verificar o valor prognóstico destas variáveis (sobrevivên [...] cia e recorrência). MÉTODOS: Uma amostra de 55 pacientes tratados cirurgicamente para GIST em três hospitais foi estudada. Os tumores extirpados cirurgicamente foram confirmados como GIST por KIT, vimentina, proteína desmina S100, CD117, 1A4 e avaliação de CD34 em blocos de parafina. RESULTADOS: Apenas nove (16%) casos de GIST foram positivos para p53, p16 foi positiva em 43,6%, 80% dos GIST apresentaram coloração para Bcl-2. O índice proliferativo (expresso como a proporção de células positivas), avaliado pela expressão imunoistoquímica de Ki-67, foi elevado em 49% dos casos. Escores de Ki-67 elevados foram associados com alto grau histológico (p=0,0026) e índice de mitose, MI (p=0,0001). Alto índice de Ki-67 foi associado à morte. Expressão da p53, p16 e Bcl-2 não se correlacionou com as variáveis morfológicas ou clínicas. CONCLUSÕES: A avaliação imunoistoquímica de Ki-67 deve ser incluída na avaliação pré-operatória de biópsias ou peças cirúrgicas de GIST como uma ferramenta prognóstica para o estadiamento clínico, e todas as outras proteínas estudadas (Bcl-2, p53 e p16) não desempenharam um papel no processo metabólico ou carcinogênico em GIST, mantendo-se sem valor prognóstico. Abstract in english PURPOSE: To evaluate the immunohistochemical expression of p16, Ki-67, p53 and Bcl-2 proteins in gastrointestinal stromal tumors (GIST); to assess the possible association between these variables and clinical and histopathological factors of cancer; and to check for prognostic value of these variabl [...] es (survival and recurrence). METHODS: A sample of 55 patients treated surgically for GIST in three hospitals was studied. The surgically excised tumors were confirmed as GIST by KIT, vimentin, desmin S100 protein, CD117, 1A4 and CD34 assessment in paraffin blocks. RESULTS: Only 9 (16%) cases of GIST were positive for p53, p16 was positive among 43.6%; 80% of GISTs showed staining for Bcl-2. The proliferative index (expressed as the proportion of positive cells) assessed by immunohistochemical expression of Ki-67 was high in 49% of cases. Elevated Ki-67 scores were associated to high histological grade (p=0.0026) and mitosis index, MI (p=0.0001). High Ki-67 index was associated to death. Expression of p53, p16 and Bcl-2 did not correlate to morphological or clinical variables. CONCLUSIONS: Ki-67 immunohistochemical evaluation should be included in preoperative evaluation of GIST biopsies or surgical specimens as a prognostic tool for clinical staging; and all other proteins studied (Bcl-2, p53 and p16) did not play a role in GIST metabolic or carcinogenic process, remaining without prognostic value.

  20. Comparison of BISAP Score with Ranson Score in Determining the Severity of Acute Pancreatitis

    International Nuclear Information System (INIS)

    Objective:To determine the accuracy of BISAPscore in finding out the frequency of severity and mortality in patients with acute pancreatitis by comparing it with Ranson score. Study Design: Crosse-sectional study. Place and Duration of Study: Department of Surgery, Pakistan Institute of Medical Sciences, Islamabad, from April to December 2010. Methodology: A total of 80 patients who presented in emergency with acute pancreatitis were included by consecutive non probability sampling technique. Cases of acute pancreatitis were classified as mild or severe based on the organ failure criteria and/or local complications according to the Atlanta Symposium. All patients were scored according to both Ranson score and BISAP score. Results: Out of 80 patients, 35 (44 percentage) were males and 45 (56 percentage) were females. The mean age was 46.89 ± 15.75 years. Twenty five patients (31.25 percentage) were classified as severe acute pancreatitis and 3 patients (3.75 percentage) had evidence of pancreatic necrosis on CT scan. The duration of hospital stay was 1 - 54 days with a mean of 13.12 ± 12.83 days and mortality rate was 5 percentage. The number of patients with a BISAP score of =3 was 15 and Ranson score =3 was 25. The observed incidence of severe disease stratified by the BISAP score has (p greater than 0.001) and by Ranson score has (p greater than 0.001). In regards to mortality, patients having BISAP score =3 has p=0.003, while patients having Ranson score =3 has p=0.002, both are statistically significant. Conclusion:The newly proposed BISAPscore is a simple and accurate tool for severity stratification and is equally effective in finding out frequency of severity and in turns mortality in patients with acute pancreatitis as Ranson score. (author)

  1. Criteria for performance evaluation

    Directory of Open Access Journals (Sweden)

    David J. Weiss

    2009-03-01

    Full Text Available Using a cognitive task (mental calculation and a perceptual-motor task (stylized golf putting, we examined differential proficiency using the CWS index and several other quantitative measures of performance. The CWS index (Weiss and Shanteau, 2003 is a coherence criterion that looks only at internal properties of the data without incorporating an external standard. In Experiment 1, college students (n = 20 carried out 2- and 3-digit addition and multiplication problems under time pressure. In Experiment 2, experienced golfers (n = 12, also college students, putted toward a target from nine different locations. Within each experiment, we analyzed the same responses using different methods. For the arithmetic tasks, accuracy information (mean absolute deviation from the correct answer, MAD using a coherence criterion was available; for golf, accuracy information using a correspondence criterion (mean deviation from the target, also MAD was available. We ranked the performances of the participants according to each measure, then compared the orders using Spearman's rextsubscript{s}. For mental calculation, the CWS order correlated moderately (rextsubscript{s} =.46 with that of MAD. However, a different coherence criterion, degree of model fit, did not correlate with either CWS or accuracy. For putting, the ranking generated by CWS correlated .68 with that generated by MAD. Consensual answers were also available for both experiments, and the rankings they generated correlated highly with those of MAD. The coherence vs. correspondence distinction did not map well onto criteria for performance evaluation.

  2. Instant MuseScore

    CERN Document Server

    Shinn, Maxwell

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. Instant MuseScore is written in an easy-to follow format, packed with illustrations that will help you get started with this music composition software.This book is for musicians who would like to learn how to notate music digitally with MuseScore. Readers should already have some knowledge about musical terminology; however, no prior experience with music notation software is necessary.

  3. Characteristics and Psychiatric Symptoms of Internet Gaming Disorder among Adults Using Self-Reported DSM-5 Criteria

    Science.gov (United States)

    Kim, Na Ri; Hwang, Samuel Suk-Hyun; Choi, Jung-Seok; Kim, Dai-Jin; Demetrovics, Zsolt; Király, Orsolya; Nagygyörgy, Katalin; Griffiths, Mark. D.; Hyun, So Yeon; Youn, Hyun Chul

    2016-01-01

    Objective The Section III of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) proposed nine diagnostic criteria and five cut-point criteria for Internet Gaming Disorder (IGD). We aimed to examine the efficacy of such criteria. Methods Adults (n=3041, men: 1824, women: 1217) who engaged in internet gaming within last 6 months completed a self-report online survey using the suggested wordings of the criteria in DSM-5. Major characteristics, gaming behavior, and psychiatric symptoms of IGD were analyzed using ANOVA, chi-square, and correlation analyses. Results The sociodemographic variables were not statistically significant between the healthy controls and the risk group. Among the participants, 419 (13.8%) were identified and labeled as the IGD risk group. The IGD risk group scored significantly higher on all motivation subscales (p<0.001). The IGD risk group showed significantly higher scores than healthy controls in all nine psychiatric symptom dimensions, i.e., somatization, obsession-compulsion, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism (p<0.001). Conclusion The IGD risk group showed differential psychopathological manifestations according to DSM-5 IGD diagnostic criteria. Further studies are needed to evaluate the reliability and validity of the specific criteria, especially for developing screening instruments.

  4. Criterios ecográficos diagnósticos de neoplasia maligna en el nódulo tiroideo: correlación con la punción por aspiración con aguja fina y la anatomía patológica / Ultrasound diagnostic criteria of malignancy in a thyroid nodule: correlation with fine needle aspiration and pathology

    Scientific Electronic Library Online (English)

    Andrés Ignacio, Chala; Rafael, Pava; Humberto Ignacio, Franco; Andrés, Álvarez; Armando, Franco.

    2013-03-01

    Full Text Available Introducción. La ecografía de tiroides ha mejorado la certeza diagnóstica para neoplasia maligna del nódulo tiroideo. Es importante definir qué nódulos requieren biopsia por aspiración con aguja fina (BACAF) para disminuir el costo de un procedimiento innecesario y evitar que pase inadvertido el dia [...] gnóstico de neoplasia maligna. Objetivo. Validar los criterios ecográficos de neoplasia maligna que indican la punción por aspiración con aguja fina de tiroides. Materiales y métodos. Se diseñó un estudio prospectivo a tres años para evaluar la concordancia entre los hallazgos ecográficos y la punción por aspiración con aguja fina de tiroides comparada con el estudio final de histopatología. Se evaluó la sensibilidad, la especificidad, el valor diagnóstico positivo y negativo, la concordancia medida por el coeficiente kappa y el coeficiente de correlación. Resultados. Se estudiaron 1.467 pacientes, 10,2 % hombres y 89,8 % mujeres, con edades entre los 10 y los 95 años; el tamaño promedio del nódulo fue de 16 mm. Un total de 623 requirieron tiroidectomía; al resto se les hizo seguimiento por ecografía. Se presentaron 269 carcinomas papilares, 14 foliculares, 4 indiferenciados, 159 bocios, 74 adenomas y 101 tiroiditis. Se obtuvo sensibilidad de 86,4 %, especificidad de 89,4 %, valor diagnóstico de un resultado positivo de 87,5 % y uno negativo de 84,1 %. Los hallazgos ecográficos relacionados con cáncer fueron: hipoecogenicidad, microcalcificaciones, papilas y flujo intranodular. Individualmente, la concordancia fue baja, pero con la combinación de hipoecogenicidad, microcalcificaciones y papilas fue media y, con la adición de aumento del flujo intranodular, resultó alta. Conclusiones. La combinación de hipoecogenicidad, microcalcificaciones, papilas y alto flujo intranodular tiene alta concordancia con neoplasia maligna; sin embargo, cada criterio por separado no la tiene, y no pueden usarse individualmente para predecir o descartar neoplasia maligna. Abstract in english Introduction. Thyroid ultrasound has improved the diagnostic accuracy in the diagnosis of malignant neoplasia in thyroid nodules. It is important to define which nodules require fine needle aspiration so as to diminish the costs of unnecessary procedures and at the same time avoid unnoticed malignan [...] cy. Objective. To validate the echographic criteria of malignant neoplasia that validate fine needle aspiration of the thyroid nodule. Material and methods. Three-year prospective study to assess correlation between the ultrasound findings and fine needle aspiration with pathology findings, including sensibility, specificity, positive predictive value, negative predictive value, and concordance measured by Kappa coefficient, and correlation coefficient. Results. The study included 1,467 patients, 10,2% males and 89,8% females, with ages ranging from 10 years to 95 years; average size of the nodule was 16 mm; 623 patients required thyroidectomy, while the remainder were followed by ultrasound. There were 269 papillary carcinomas, 14 follicular carcinomas, 4 anaplastic carcinomas, 159 goiters, 74 adenomas, and 101 thyroiditis. Sensibility was 86,4%, specificity was 89,4%, positive predictive value 87,5%, and negative predictive value 84,1%. Ultrasound findings related with cancer were hypoechogenicity, microcalcifications, papillae, and intranodal flow; when adding intranodal flow, concordance was high. Conclusions. The combination of hypoechogenicity, microcalcifications, papillae and high intranodal flow exhibit high concordance with malignancy; however, echographic criteria considered individually does not, and those individual criteria cannot be used to predict or rule out malignant neoplasia.

  5. Criterios ecográficos diagnósticos de neoplasia maligna en el nódulo tiroideo: correlación con la punción por aspiración con aguja fina y la anatomía patológica Ultrasound diagnostic criteria of malignancy in a thyroid nodule: correlation with fine needle aspiration and pathology

    Directory of Open Access Journals (Sweden)

    Andrés Ignacio Chala

    2013-03-01

    Full Text Available Introducción. La ecografía de tiroides ha mejorado la certeza diagnóstica para neoplasia maligna del nódulo tiroideo. Es importante definir qué nódulos requieren biopsia por aspiración con aguja fina (BACAF para disminuir el costo de un procedimiento innecesario y evitar que pase inadvertido el diagnóstico de neoplasia maligna. Objetivo. Validar los criterios ecográficos de neoplasia maligna que indican la punción por aspiración con aguja fina de tiroides. Materiales y métodos. Se diseñó un estudio prospectivo a tres años para evaluar la concordancia entre los hallazgos ecográficos y la punción por aspiración con aguja fina de tiroides comparada con el estudio final de histopatología. Se evaluó la sensibilidad, la especificidad, el valor diagnóstico positivo y negativo, la concordancia medida por el coeficiente kappa y el coeficiente de correlación. Resultados. Se estudiaron 1.467 pacientes, 10,2 % hombres y 89,8 % mujeres, con edades entre los 10 y los 95 años; el tamaño promedio del nódulo fue de 16 mm. Un total de 623 requirieron tiroidectomía; al resto se les hizo seguimiento por ecografía. Se presentaron 269 carcinomas papilares, 14 foliculares, 4 indiferenciados, 159 bocios, 74 adenomas y 101 tiroiditis. Se obtuvo sensibilidad de 86,4 %, especificidad de 89,4 %, valor diagnóstico de un resultado positivo de 87,5 % y uno negativo de 84,1 %. Los hallazgos ecográficos relacionados con cáncer fueron: hipoecogenicidad, microcalcificaciones, papilas y flujo intranodular. Individualmente, la concordancia fue baja, pero con la combinación de hipoecogenicidad, microcalcificaciones y papilas fue media y, con la adición de aumento del flujo intranodular, resultó alta. Conclusiones. La combinación de hipoecogenicidad, microcalcificaciones, papilas y alto flujo intranodular tiene alta concordancia con neoplasia maligna; sin embargo, cada criterio por separado no la tiene, y no pueden usarse individualmente para predecir o descartar neoplasia maligna.Introduction. Thyroid ultrasound has improved the diagnostic accuracy in the diagnosis of malignant neoplasia in thyroid nodules. It is important to define which nodules require fine needle aspiration so as to diminish the costs of unnecessary procedures and at the same time avoid unnoticed malignancy. Objective. To validate the echographic criteria of malignant neoplasia that validate fine needle aspiration of the thyroid nodule. Material and methods. Three-year prospective study to assess correlation between the ultrasound findings and fine needle aspiration with pathology findings, including sensibility, specificity, positive predictive value, negative predictive value, and concordance measured by Kappa coefficient, and correlation coefficient. Results. The study included 1,467 patients, 10,2% males and 89,8% females, with ages ranging from 10 years to 95 years; average size of the nodule was 16 mm; 623 patients required thyroidectomy, while the remainder were followed by ultrasound. There were 269 papillary carcinomas, 14 follicular carcinomas, 4 anaplastic carcinomas, 159 goiters, 74 adenomas, and 101 thyroiditis. Sensibility was 86,4%, specificity was 89,4%, positive predictive value 87,5%, and negative predictive value 84,1%. Ultrasound findings related with cancer were hypoechogenicity, microcalcifications, papillae, and intranodal flow; when adding intranodal flow, concordance was high. Conclusions. The combination of hypoechogenicity, microcalcifications, papillae and high intranodal flow exhibit high concordance with malignancy; however, echographic criteria considered individually does not, and those individual criteria cannot be used to predict or rule out malignant neoplasia.

  6. Admissions Criteria as Predictors of Academic Performance in a Three-Year Pharmacy Program at a Historically Black Institution

    Science.gov (United States)

    Parmar, Jayesh R.; Purnell, Miriam; Lang, Lynn A.

    2016-01-01

    Objective. To determine the ability of University of Maryland Eastern Shore School of Pharmacy’s admissions criteria to predict students’ academic performance in a 3-year pharmacy program and to analyze transferability to African-American students. Methods. Statistical analyses were conducted on retrospective data for 174 students. Didactic and experiential scores were used as measures of academic performance. Results. Pharmacy College Admission Test (PCAT), grade point average (GPA), interview, and observational scores combined with previous pharmacy experience and biochemistry coursework predicted the students' academic performance except second-year (P2) experiential performance. For African-American students, didactic performance positively correlated with PCAT writing subtests, while the experiential performance positively correlated with previous pharmacy experience and observational score. For nonAfrican-American students, didactic performance positively correlated with PCAT multiple-choice subtests, and experiential performance with interview score. The prerequisite GPA positively correlated with both of the student subgroups’ didactic performance. Conclusion. Both PCAT and GPA were predictors of didactic performance, especially in nonAfrican-Americans. Pharmacy experience and observational scores were predictors of experiential performance, especially in African-Americans. PMID:26941432

  7. Introduction of a new standardized assessment score of spine morphology in osteogenesis imperfecta

    International Nuclear Information System (INIS)

    Purpose: Osteogenesis imperfecta (OI) is a rare hereditary disease leading to multiple bone deformities and fractures. In the absence of causal therapy, a symptomatic approach is based on treatment with bisphosphonates and physiotherapy. The clinical and radiological manifestations vary. Therefore, standardization and quantification for an objective comparison, especially during therapy, are required. In this paper, radiological changes of the spine are quantified according to their clinical relevance to define a scoring system that transfers the morphological changes into a single value representing the severity of the disease. Materials and Methods: 268 lateral spine X-rays of 95 patients with OI (median age 5.6 years) were assessed. The findings were classified based on their clinical relevance. Results: The three criteria, vertebral compression, thoracolumbar kyphosis and deformity type, were quantified in a new grading system. Based on this, a 'severity classification' (1 to 5) was defined with implications for diagnostics and treatment. A mathematical formula that takes into account the three criteria and their correlations to clinical relevance, resulting in a 'severity score', was developed. Conclusion: 'Severity classification' and 'severity score' introduce a new concept for a standardized evaluation of spine X-rays in patients with OI. For both scientific and routine purposes, it provides the user with a simple and easy-to-handle tool for assessing and comparing different stages of severity prior to and during therapy with detailed accuracy. (orig.)

  8. Introduction of a new standardized assessment score of spine morphology in osteogenesis imperfecta

    Energy Technology Data Exchange (ETDEWEB)

    Koerber, F.; Schulze Uphoff, U.; Koerber, S.; Maintz, D. [Koeln Univ. (Germany). Dept. of Radiology; Schoenau, E.; Semler, O. [Koeln Univ. (Germany). Children' s Hospital

    2012-08-15

    Purpose: Osteogenesis imperfecta (OI) is a rare hereditary disease leading to multiple bone deformities and fractures. In the absence of causal therapy, a symptomatic approach is based on treatment with bisphosphonates and physiotherapy. The clinical and radiological manifestations vary. Therefore, standardization and quantification for an objective comparison, especially during therapy, are required. In this paper, radiological changes of the spine are quantified according to their clinical relevance to define a scoring system that transfers the morphological changes into a single value representing the severity of the disease. Materials and Methods: 268 lateral spine X-rays of 95 patients with OI (median age 5.6 years) were assessed. The findings were classified based on their clinical relevance. Results: The three criteria, vertebral compression, thoracolumbar kyphosis and deformity type, were quantified in a new grading system. Based on this, a 'severity classification' (1 to 5) was defined with implications for diagnostics and treatment. A mathematical formula that takes into account the three criteria and their correlations to clinical relevance, resulting in a 'severity score', was developed. Conclusion: 'Severity classification' and 'severity score' introduce a new concept for a standardized evaluation of spine X-rays in patients with OI. For both scientific and routine purposes, it provides the user with a simple and easy-to-handle tool for assessing and comparing different stages of severity prior to and during therapy with detailed accuracy. (orig.)

  9. Differences in gestational weight gain between pregnancies before and after maternal bariatric surgery correlate with differences in birth weight but not with scores on the body mass index in early childhood

    DEFF Research Database (Denmark)

    Berglind, D; Willmer, M

    2013-01-01

    Large maternal gestational weight gain (GWG) is associated with increased birth weight and increased risk of obesity in offspring, but these associations may be confounded by genetic and environmental factors. The aim was to investigate the effects of differences in GWG in all three trimesters on differences in birth weight and in body mass index (BMI) scores at 4 and 6 years of age, within siblings born before and after bariatric surgery.

  10. Calculating a Score of Sustainable Development

    Directory of Open Access Journals (Sweden)

    Fatih ÇEMREK

    2013-12-01

    Full Text Available Sustainable development is considered to be one of the most important economic issues today. Sustainable development indicators are taken into account when comparing the countries in terms of the level of development. Besides, these indicators are taken to be a major source of information in deciding the development policies the countries will follow as well as for a wide range of investment decisions. In this study, by using sustainable development indicators, we develop scores of sustainable development for the Commonwealth of Indepen-dent States (CIS, the Baltic Republics (BC and Russia in the context of principal components analysis. Subsequently, the sustainable development scores of the investigated countries and the United Nations Human Development Index (HDI scores were compared, and the relationship between the two was evaluated. The correlation coefficient between the two scores was found to be 0.872 and statistically significant at 1 % level.

  11. Fetal Biophysical Profile Scoring

    Directory of Open Access Journals (Sweden)

    H.R. HaghighatKhah

    2009-01-01

    Full Text Available   "nFetal biophysical profile scoring is a sonographic-based method of fetal assessment first described by Manning and Platt in 1980. "nThe biophysical profile score was developed as a method to integrate real-time observations of the fetus and his/her intrauterine environment in order to more comprehensively assess the fetal condition. These findings must be evaluated in the context of maternal/fetal history (i.e., chronic hypertension, post-dates, intrauterine growth restriction, etc, fetal structural integrity (presence or absence of congenital anomalies, and the functionality of fetal support structures (placental and umbilical cord. For example, acute asphyxia due to placental abruption may result in an absence of the acute variables of the biophysical profile score (fetal breathing movements, fetal movement, fetal tone, and fetal heart rate reactivity with a normal amniotic fluid volume. With post maturity the asphyxial event may be intermittent and chronic resulting in a decrease in amniotic fluid volume, but with the acute variables remaining normal. "nWhile the 5 components of the biophysical profile score have remained unchanged since 1980 (Manning, 1980, the definitions of a normal and abnormal parameter have evolved with increasing experience. "nIn 1984 the definition of oligohydramnios was increased from < 1cm pocket of fluid to < 2.0 x 1.0 cm pocket. Oligohydramnios is now defined as a pocket of amniotic fluid < 2.0 x 2.0 cm (Manning, 1995a "nIf the four ultrasound variables are normal, the accuracy of the biophysical profile score was not found to be significantly improved by adding the non-stress test. As a result, in 1987 the profile score was modified to incorporate the non-stress test only when one of the ultrasound variables was abnormal (Manning 1987. Table 1 outlines the current definitions for quantifying a variable as present or absent. "nEach of the 5 components of the biophysical profile score does not have equal significance. Fetal breathing movements, amniotic fluid volume, and the non-stress test are the most powerful variables. For example, when the biophysical profile score is 2, the perinatal mortality varies between 428/1000 with only fetal movement present to 66/1000 if the non-stress test is reactive and all of the ultrasound parameters are absent (Manning 1990b. Some authors have, therefore, proposed utilization of a modified biophysical profile that incorporates only the non-stress test and amniotic fluid volume (Miller 1996. Although the positive predictive value of these 2 tests is equivalent to a biophysical profile score of 6, the perinatal mortality is still increased over a normal test score of 8 or 10 (Manning 1990b. The false positive rate with the modified biophysical profile score is also substantially higher. "nConclusions: The fetus expresses its well being or compromised status through a number of different biophysical activities that are controlled by different central nervous system centers. The utilization of the biophysical score for antepartum surveillance in high-risk patients has resulted in a reduction in perinatal mortality when compared to historical controls. The appropriate management of the viable fetus with an abnormal biophysical profile score may also decrease long-term neurological morbidity (Manning 1998. "nIt is unlikely that in the future additional variables will be added to the biophysical profile score. However, perhaps the incorporation of the fetal state (i.e., eye movements and Doppler flow studies of specific fetal vessels (umbilical artery, middle cerebral artery, ductus venosus will be incorporated into a complete assessment of the fetal condition "n "nTable 1. Components of the 30 Minute Biophysical Profile Score "nComponent "nDefinition "nFetal movements "n> 3 body or limb movements "nFetal tone "nOne episode of active extension and flexion of the limbs; opening and closing of hand "nFetal breathing movements "n>1 episode of >30 seconds in 30 minutes "n- Hiccups are considered breathing activity. "nAmniotic fluid volume "nA single 2 cm x 2 cm pocket is considered adequate. "nNon-stress test "n2 accelerations > 15 beats per minute of at least 15 seconds duration.    

  12. Comparative Evaluation of Urinary PCA3 and TMPRSS2: ERG Scores and Serum PHI in Predicting Prostate Cancer Aggressiveness

    Directory of Open Access Journals (Sweden)

    Lucile Tallon

    2014-07-01

    Full Text Available It has been suggested that urinary PCA3 and TMPRSS2:ERG fusion tests and serum PHI correlate to cancer aggressiveness-related pathological criteria at prostatectomy. To evaluate and compare their ability in predicting prostate cancer aggressiveness, PHI and urinary PCA3 and TMPRSS2:ERG (T2 scores were assessed in 154 patients who underwent radical prostatectomy for biopsy-proven prostate cancer. Univariate and multivariate analyses using logistic regression and decision curve analyses were performed. All three markers were predictors of a tumor volume ?0.5 mL. Only PHI predicted Gleason score ?7. T2 score and PHI were both independent predictors of extracapsular extension (?pT3, while multifocality was only predicted by PCA3 score. Moreover, when compared to a base model (age, digital rectal examination, serum PSA, and Gleason sum at biopsy, the addition of both PCA3 score and PHI to the base model induced a significant increase (+12% when predicting tumor volume >0.5 mL. PHI and urinary PCA3 and T2 scores can be considered as complementary predictors of cancer aggressiveness at prostatectomy.

  13. Criteria for the diagnosis of corticobasal degeneration

    OpenAIRE

    Armstrong, Melissa J.; Litvan, Irene; Lang, Anthony E; Bak, Thomas H; Bhatia, Kailash P.; Borroni, Barbara; Boxer, Adam L.; Dickson, Dennis W; Grossman, Murray; Hallett, Mark; Josephs, Keith A.; Kertesz, Andrew; Lee, Suzee E.; Bruce L. Miller; Reich, Stephen G.

    2013-01-01

    Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations. An international consortium of behavioral neurology, neuropsychology, and movement disorders specialists developed new criteria based on consensus and a systematic literature review. Clinical diagnoses (early or late) were identified for 267 nonoverlapping pathologically confirmed CBD cases...

  14. Structured Interactive Music Scores

    OpenAIRE

    Toro, Mauricio

    2015-01-01

    Interactive Scores is a formalism for the design and performance of interactive scenarios that provides temporal relations (TRs) among the objects of the scenario. We can model TRs among objects in Time Stream Petri nets, but it is difficult to represent global constraints. This can be done explicitly in the Non-deterministic Timed Concurrent Constraint (ntcc) calculus. We want to formalize a heterogeneous system that controls in one subsystem the concurrent execution of the...

  15. Credit scoring methods.

    Czech Academy of Sciences Publication Activity Database

    Vojtek, Martin; Ko?enda, Evžen

    2006-01-01

    Ro?. 56, 3-4 (2006), s. 152-167. ISSN 0015-1920 R&D Projects: GA ?R GA402/05/0931 Institutional research plan: CEZ:AV0Z70850503 Keywords : banking sector * credit scoring * discrimination analysis Subject RIV: AH - Economics Impact factor: 0.190, year: 2006 http://journal.fsv.cuni.cz/storage/1050_s_152_167.pdf

  16. Fico credit scores

    OpenAIRE

    Zhyltsova, D.O.

    2014-01-01

    A credit score is index, which measures the credit risk. It absorbs the information from your credit history into a single number at a particular point of time. This forms a basis for the assessment of your credit report and rating your credit risk by lenders. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/34934

  17. Description and validation of a scoring system for tomosynthesis in pulmonary cystic fibrosis

    International Nuclear Information System (INIS)

    To design and validate a scoring system for tomosynthesis (digital tomography) in pulmonary cystic fibrosis. A scoring system dedicated to tomosynthesis in pulmonary cystic fibrosis was designed. Three radiologists independently scored 88 pairs of radiographs and tomosynthesis examinations of the chest in 60 patients with cystic fibrosis and 7 oncology patients. Radiographs were scored according to the Brasfield scoring system and tomosynthesis examinations were scored using the new scoring system. Observer agreements for the tomosynthesis score were almost perfect for the total score with square-weighted kappa >0.90, and generally substantial to almost perfect for subscores. Correlation between the tomosynthesis score and the Brasfield score was good for the three observers (Kendall's rank correlation tau 0.68, 0.77 and 0.78). Tomosynthesis was generally scored higher as a percentage of the maximum score. Observer agreements for the total score for Brasfield score were almost perfect (square-weighted kappa 0.80, 0.81 and 0.85). The tomosynthesis scoring system seems robust and correlates well with the Brasfield score. Compared with radiography, tomosynthesis is more sensitive to cystic fibrosis changes, especially bronchiectasis and mucus plugging, and the new tomosynthesis scoring system offers the possibility of more detailed and accurate scoring of disease severity. (orig.)

  18. Description and validation of a scoring system for tomosynthesis in pulmonary cystic fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Vult von Steyern, Kristina; Bjoerkman-Burtscher, Isabella M.; Bozovic, Gracijela; Wiklund, Marie; Geijer, Mats [Skaane University Hospital, Lund University, Centre for Medical Imaging and Physiology, Lund (Sweden); Hoeglund, Peter [Skaane University Hospital, Competence Centre for Clinical Research, Lund (Sweden)

    2012-12-15

    To design and validate a scoring system for tomosynthesis (digital tomography) in pulmonary cystic fibrosis. A scoring system dedicated to tomosynthesis in pulmonary cystic fibrosis was designed. Three radiologists independently scored 88 pairs of radiographs and tomosynthesis examinations of the chest in 60 patients with cystic fibrosis and 7 oncology patients. Radiographs were scored according to the Brasfield scoring system and tomosynthesis examinations were scored using the new scoring system. Observer agreements for the tomosynthesis score were almost perfect for the total score with square-weighted kappa >0.90, and generally substantial to almost perfect for subscores. Correlation between the tomosynthesis score and the Brasfield score was good for the three observers (Kendall's rank correlation tau 0.68, 0.77 and 0.78). Tomosynthesis was generally scored higher as a percentage of the maximum score. Observer agreements for the total score for Brasfield score were almost perfect (square-weighted kappa 0.80, 0.81 and 0.85). The tomosynthesis scoring system seems robust and correlates well with the Brasfield score. Compared with radiography, tomosynthesis is more sensitive to cystic fibrosis changes, especially bronchiectasis and mucus plugging, and the new tomosynthesis scoring system offers the possibility of more detailed and accurate scoring of disease severity. (orig.)

  19. Earthquake forecast enrichment scores

    Directory of Open Access Journals (Sweden)

    Christine Smyth

    2012-03-01

    Full Text Available The Collaboratory for the Study of Earthquake Predictability (CSEP is a global project aimed at testing earthquake forecast models in a fair environment. Various metrics are currently used to evaluate the submitted forecasts. However, the CSEP still lacks easily understandable metrics with which to rank the universal performance of the forecast models. In this research, we modify a well-known and respected metric from another statistical field, bioinformatics, to make it suitable for evaluating earthquake forecasts, such as those submitted to the CSEP initiative. The metric, originally called a gene-set enrichment score, is based on a Kolmogorov-Smirnov statistic. Our modified metric assesses if, over a certain time period, the forecast values at locations where earthquakes have occurred are significantly increased compared to the values for all locations where earthquakes did not occur. Permutation testing allows for a significance value to be placed upon the score. Unlike the metrics currently employed by the CSEP, the score places no assumption on the distribution of earthquake occurrence nor requires an arbitrary reference forecast. In this research, we apply the modified metric to simulated data and real forecast data to show it is a powerful and robust technique, capable of ranking competing earthquake forecasts.

  20. Pronuclear scoring as a predictor of embryo quality in in vitro fertilization program.

    Directory of Open Access Journals (Sweden)

    Leszek Pawelczyk

    2008-04-01

    Full Text Available Many strategies have been proposed for the selection of viable embryos for transfer in human assisted reproduction. These have included morphological scoring criteria for 20, 28, 44 and 68 h after insemination. The embryo selection is based on morphology, degree of fragmentation and development to the 8-cell. All have shown some correlation with implantation. However, the overall success of these methods is still limited, with over 50% of all transferred embryos failing to implant. Pronuclear zygote morphology has gained much attention recently due to its positive value in predicting implantation and pregnancy. This prospective study involved 178 conventional IVF patients only. The key aspects of pronuclear scoring and namely the presence of a cytoplasmic halo were related to day 3 of development and morphology in a retrospective study. The Z-score and the presence/absence of a halo had significant effect on the rate of development on day 3 embryo. Low Z-score result in slow development and poor morphology. The absence of a halo also resulted in slow and poor development, low morphology, increased fragmentation.

  1. Association between eating behavior scores and obesity in Chilean children

    OpenAIRE

    Amador Paola; Obregón Ana M; Cataldo Rodrigo; Domínguez-Vásquez Patricia; Smalley Susan V; González Andrea; Ho-Urriola Judith A; Santos José L; Weisstaub Gerardo; Hodgson M Isabel

    2011-01-01

    Abstract Background Inadequate eating behavior and physical inactivity contribute to the current epidemic of childhood obesity. The aim of this study was to assess the association between eating behavior scores and childhood obesity in Chilean children. Design and methods We recruited 126 obese, 44 overweight and 124 normal-weight Chilean children (6-12 years-old; both genders) according to the International Obesity Task Force (IOTF) criteria. Eating behavior scores were calculated using the ...

  2. Validating MMI scores: are we measuring multiple attributes?

    Science.gov (United States)

    Oliver, Tom; Hecker, Kent; Hausdorf, Peter A; Conlon, Peter

    2014-08-01

    The multiple mini-interview (MMI) used in health professional schools' admission processes is reported to assess multiple non-cognitive constructs such as ethical reasoning, oral communication, or problem evaluation. Though validation studies have been performed with total MMI scores, there is a paucity of information regarding how well MMI scores differentiate the constructs being measured, the relationship between MMI scores (construct or total) and personality characteristics, and how well MMI scores (construct or total) predict future performance in practice. Results from these studies could assist with MMI station development, rater training, score interpretation, and resource allocation. The purpose of this study was to investigate the validity of MMI construct scores (oral communication and problem evaluation), and their relationship to personality measures (emotionality and extraversion) and specific scores from standardized clinical communications interviews (building the relationship and explaining and planning). Confirmatory factor analysis results support a two factor MMI model, however the correlation between these factors was .87. Oral communication MMI scores significantly correlated with extraversion (r c = .25, p evaluation scores (r c = .43, p evaluation scores (r c = .36, p cognitive attributes during the MMI process and reinforce the importance of developing MMI stations and scoring rubrics for attributes identified as important for future success in school and practice. PMID:24449121

  3. Differences in gestational weight gain between pregnancies before and after maternal bariatric surgery correlate with differences in birth weight but not with scores on the body mass index in early childhood

    DEFF Research Database (Denmark)

    Berglind, D; Willmer, M; Näslund, E; Tynelius, P; Sørensen, T I A; Rasmussen, F

    2013-01-01

    Large maternal gestational weight gain (GWG) is associated with increased birth weight and increased risk of obesity in offspring, but these associations may be confounded by genetic and environmental factors. The aim was to investigate the effects of differences in GWG in all three trimesters on...... differences in birth weight and in body mass index (BMI) scores at 4 and 6 years of age, within siblings born before and after bariatric surgery.......Large maternal gestational weight gain (GWG) is associated with increased birth weight and increased risk of obesity in offspring, but these associations may be confounded by genetic and environmental factors. The aim was to investigate the effects of differences in GWG in all three trimesters on...

  4. Students' proficiency scores within multitrait item response theory

    Science.gov (United States)

    Scott, Terry F.; Schumayer, Daniel

    2015-12-01

    In this paper we present a series of item response models of data collected using the Force Concept Inventory. The Force Concept Inventory (FCI) was designed to poll the Newtonian conception of force viewed as a multidimensional concept, that is, as a complex of distinguishable conceptual dimensions. Several previous studies have developed single-trait item response models of FCI data; however, we feel that multidimensional models are also appropriate given the explicitly multidimensional design of the inventory. The models employed in the research reported here vary in both the number of fitting parameters and the number of underlying latent traits assumed. We calculate several model information statistics to ensure adequate model fit and to determine which of the models provides the optimal balance of information and parsimony. Our analysis indicates that all item response models tested, from the single-trait Rasch model through to a model with ten latent traits, satisfy the standard requirements of fit. However, analysis of model information criteria indicates that the five-trait model is optimal. We note that an earlier factor analysis of the same FCI data also led to a five-factor model. Furthermore the factors in our previous study and the traits identified in the current work match each other well. The optimal five-trait model assigns proficiency scores to all respondents for each of the five traits. We construct a correlation matrix between the proficiencies in each of these traits. This correlation matrix shows strong correlations between some proficiencies, and strong anticorrelations between others. We present an interpretation of this correlation matrix.

  5. Association of Apgar scores with death and neurologic disability

    OpenAIRE

    Vera Ehrenstein

    2009-01-01

    Vera EhrensteinDepartment of Clinical Epidemiology, Aarhus University Hospital, DenmarkAbstract: Apgar score was devised with the aim to standardize the assessment of newborns. It has been used worldwide to evaluate infants’ condition immediately after birth, to determine their need for resuscitation, and to evaluate the effectiveness of resuscitation. Apgar score was never intended for prediction of outcome beyond the immediate postnatal period; however, since low scores correlate ...

  6. Brief, unidimensional melancholia rating scales are highly sensitive to the effect of citalopram and may have biological validity: Domain Criteria (RDoC)

    DEFF Research Database (Denmark)

    Ostergaard, Søren D; Bech, Per; Trivedi, Madhukar H; Wisniewski, Stephen R; Rush, A John; Fava, Maurizio

    2014-01-01

    . Symptom change, response and remission rates were compared for HAM-D6 versus HAM-D17 and for IDS-C6 versus IDS-C30. The changes in total scores on these scales were compared to the change in Quality of Life Enjoyment and Satisfaction Questionnaire (QLES-Q) score using correlation analysis. RESULTS: The....... We therefore believe that "melancholia" thus defined could be a valuable construct under the Research Domain Criteria (RDoC), which specifically aims at identifying the neurobiology underlying mental disorders and providing drugable targets....

  7. Criteria for site selection

    International Nuclear Information System (INIS)

    This article begins by examining the sense and purpose of the lists of criteria used as a basis for repository site selection. This, in turn, allows a more accurate appraisal of existing criteria, particularly those identified in international studies. The following chapter looks at the criteria used in assessing Swiss repository projects; HLW and LLW/ILW are considered separately. The article closes with a list of the official site selection criteria in Switzerland. (author) 15 refs., 3 figs., 2 tabs

  8. Green Supplier Selection Criteria

    DEFF Research Database (Denmark)

    Nielsen, Izabela Ewa; Banaeian, Narges; Golinska, Paulina; Mobli, Hossein; Omid, Mahmoud

    supplier selection criteria include: frequency, compatibility, quantifiable, easy to understand and assessment. By developed framework suitable criteria can be selected using multi attribute decision making methods. The main contribution of this research is developing a framework to help managers for...... determine prevalent general and environmental supplier selection criteria and develop a framework which can help decision makers to determine and prioritize suitable green supplier selection criteria (general and environmental). In this research we considered several parameters (evaluation objectives) to...

  9. Association between scores in high school, aptitude and achievement exams and early performance in health science college

    Directory of Open Access Journals (Sweden)

    Al-Alwan Ibrahim

    2009-01-01

    Full Text Available This retrospective study was carried out to assess the correlation between admi-ssion criteria to health science colleges, namely, final high school grade and Saudi National Apti-tude and Achievement exams, and early academic performance in these colleges. The study inclu-ded 91 male students studying in the two-year pre-professional program at the King Saud bin Abdulaziz University for Health Sciences (KSAU-HS, Riyadh, Saudi Arabia. Records of these students were used to extract relevant information and their academic performance (based on the grade point average achieved at the end of the first semester of the pre-professional program, which were analytically studied. Pearson correlation coefficient was used to assess the associa-tions between the different scores. SPSS statistical program (version 12.0 was used for data ana-lyses. We found a strong correlation between the academic performance and the Achievement Exam, Aptitude Exam and high school final grade, with Pearson Correlation Coefficients of 0.96, 0.93, 0.87, respectively. The Saudi National Achievement Exam showed the most significant correla-tion. Our results indicate that academic performance showed good correlation with the admission criteria used, namely final high school grade, Saudi National Aptitude and Achievement Exams.

  10. Association between scores in high school, aptitude and achievement exams and early performance in health science college.

    Science.gov (United States)

    Al-Alwan, Ibrahim A

    2009-05-01

    This retrospective study was carried out to assess the correlation between admission criteria to health science colleges, namely, final high school grade and Saudi National Aptitude and Achievement exams, and early academic performance in these colleges. The study included 91 male students studying in the two-year pre-professional program at the King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia. Records of these students were used to extract relevant information and their academic performance (based on the grade point average achieved at the end of the first semester of the pre-professional program), which were analytically studied. Pearson correlation coefficient was used to assess the associations between the different scores. SPSS statistical program (version 12.0) was used for data analyses. We found a strong correlation between the academic performance and the Achievement Exam, Aptitude Exam and high school final grade, with Pearson Correlation Coefficients of 0.96, 0.93, 0.87, respectively. The Saudi National Achievement Exam showed the most significant correlation. Our results indicate that academic performance showed good correlation with the admission criteria used, namely final high school grade, Saudi National Aptitude and Achievement Exams. PMID:19414949

  11. Microstructural Parameters of Bone Evaluated Using HR-pQCT Correlate with the DXA-Derived Cortical Index and the Trabecular Bone Score in a Cohort of Randomly Selected Premenopausal Women.

    OpenAIRE

    Popp, Albrecht W.; Buffat, Helene; Eberli, Ursula; Lippuner, Kurt; Ernst, Manuela; Richards, R. Geoff; Stadelmann, Vincent A.; Windolf, Markus

    2014-01-01

    BACKGROUND Areal bone mineral density is predictive for fracture risk. Microstructural bone parameters evaluated at the appendicular skeleton by high-resolution peripheral quantitative computed tomography (HR-pQCT) display differences between healthy patients and fracture patients. With the simple geometry of the cortex at the distal tibial diaphysis, a cortical index of the tibia combining material and mechanical properties correlated highly with bone strength ex vivo. The trabecular bon...

  12. Ultrasonography-guided percutaneous radiofrequency ablation of hepatocellular carcinomas: A feasibility scoring system for planning sonography

    International Nuclear Information System (INIS)

    Purpose: This study was designed to evaluate whether a feasibility scoring system for planning sonography is a reliable predictor of a safe and complete ablation in ultrasonography (US)-guided percutaneous radiofrequency ablation (RFA) of hepatocellular carcinomas (HCCs). Materials and methods: We retrospectively evaluated the therapeutic outcomes of 108 consecutive patients (M:F, 78:30; mean age, 57.4 years) with a single nodular HCC (mean diameter, 2.0 cm) treated by percutaneous RFA. All patients were assessed for the feasibility of performing an RFA at planning sonography prior to the ablation. The feasibility scoring system consisted of five categories: the safe electrode path (P); the vital organs adjacent to the RFA zone (O); tumor size (S); tumor conspicuity (C); and the heat-sink effect (H). Each category was divided into a four-point scale [1-4]. If a score of 4 in any category was determined, the patient was not considered to be a suitable candidate for percutaneous RFA. We assessed if the score of each category, safety score (P + O), and curability score (S + C + H) correlated with a safe and complete ablation using the chi-squared test and likelihood ratio test for trend. Results: The technical success rate was 100% (108/108) based on CT images obtained immediately after ablation. There was no 30-day mortality after RFA. There were major complications (one case of severe vasovagal reflex, one case of hemoperitoneum and one case of a pseudoaneurysm) in three (2.7%) patients, and minor complications (one case of a biloma, one case of subsegmental infarction and one case of abscess) in three (2.7%) patients. Post-ablation syndrome as a side effect was noted in 38 (35.1%) of 108 patients. The primary technique effectiveness rate at 1 month was 95.1% (105/108). Local tumor progression was noted in eight (7.6%) of 105 patients during the follow-up period (range, 3.0-11.5 months; median, 5.8 months; mean, 5.7 months). There was no significant single category to predict complication and local tumor progression (Fisher's exact test, p > 0.05). Contrary to the safety score for the probability of complication (p > 0.05), the curability score was significantly associated with the probability of local tumor progression (likelihood ratio test for trend; p = 0.03). Conclusion: The new feasibility scoring system for planning US can be used as objective criteria to predict therapeutic efficacy rather than the safety of percutaneous RFA of an HCC.

  13. Prognostic criteria in acute pancreatitis: importance of assessment of pancreatic necrosis by contrast-enhanced CT

    International Nuclear Information System (INIS)

    To compare the value of the clinical criteria of Ranson, the classical tomographic criteria of Balthzar and the severity of illness index according to CT in predicting the development of complications of acute pancreatitis. A retrospective study was performed in 100 patients with clinical and analytical evidence of acute pancreatitis. All patients were assessed according to Ranson score at admission and 48 hours later, and contrast-enhanced abdominal CT was carried out. The tomographic images were analyzed on the basis of the classical criteria of Balthazar and the new CT severity of illness index, which includes the assessment of pancreatic necrosis, identified as the areas of the pancreas that are not enhanced by the administration of the contrast material. These three criteria were then correlated with onset of medical and surgical implications. Our findings show that, of the three criteria analyzed, the CT severity of illness index presents the greatest specificity, sensitivity and positive and negative predictive values in the prediction of complications of acute pancreatitis. We conclude that the inclusion of pancreatic necrosis in the tomographic study improves the early assessment of the prognosis of acute pancreatitis. (Author) 20 refs

  14. Night cough counts and diary card scores in asthma.

    OpenAIRE

    Archer, L N; Simpson, H.

    1985-01-01

    A tape recording system for recording night cough in asthmatics at home is described. Objective cough counts and half hour periods containing cough did not correlate with diary card scores awarded to eight children on seven nights each. Night cough diary scores may mislead in the assessment of symptom severity.

  15. Longitudinal Factor Score Estimation Using the Kalman Filter.

    Science.gov (United States)

    Oud, Johan H.; And Others

    1990-01-01

    How longitudinal factor score estimation--the estimation of the evolution of factor scores for individual examinees over time--can profit from the Kalman filter technique is described. The Kalman estimates change more cautiously over time, have lower estimation error variances, and reproduce the LISREL program latent state correlations more…

  16. National Board Scores versus Student GPA's in Chiropractic Education.

    Science.gov (United States)

    Kalthoff, Theodore J.

    1985-01-01

    The relationship between student GPAs and scores on the National Board of Chiropractic Examiners tests was investigated in an effort to determine if the chiropractic curriculum was properly preparing students to be licensed. The study found that there was a significant correlation between GPAs and board scores. (Author/MLW)

  17. Longitudinal Factor Score Estimation Using the Kalman Filter.

    Science.gov (United States)

    Oud, Johan H.; And Others

    1990-01-01

    How longitudinal factor score estimation--the estimation of the evolution of factor scores for individual examinees over time--can profit from the Kalman filter technique is described. The Kalman estimates change more cautiously over time, have lower estimation error variances, and reproduce the LISREL program latent state correlations more…

  18. Credit scores, cardiovascular disease risk, and human capital.

    Science.gov (United States)

    Israel, Salomon; Caspi, Avshalom; Belsky, Daniel W; Harrington, HonaLee; Hogan, Sean; Houts, Renate; Ramrakha, Sandhya; Sanders, Seth; Poulton, Richie; Moffitt, Terrie E

    2014-12-01

    Credit scores are the most widely used instruments to assess whether or not a person is a financial risk. Credit scoring has been so successful that it has expanded beyond lending and into our everyday lives, even to inform how insurers evaluate our health. The pervasive application of credit scoring has outpaced knowledge about why credit scores are such useful indicators of individual behavior. Here we test if the same factors that lead to poor credit scores also lead to poor health. Following the Dunedin (New Zealand) Longitudinal Study cohort of 1,037 study members, we examined the association between credit scores and cardiovascular disease risk and the underlying factors that account for this association. We find that credit scores are negatively correlated with cardiovascular disease risk. Variation in household income was not sufficient to account for this association. Rather, individual differences in human capital factors—educational attainment, cognitive ability, and self-control—predicted both credit scores and cardiovascular disease risk and accounted for ?45% of the correlation between credit scores and cardiovascular disease risk. Tracing human capital factors back to their childhood antecedents revealed that the characteristic attitudes, behaviors, and competencies children develop in their first decade of life account for a significant portion (?22%) of the link between credit scores and cardiovascular disease risk at midlife. We discuss the implications of these findings for policy debates about data privacy, financial literacy, and early childhood interventions. PMID:25404329

  19. Local Observed-Score Equating with Anchor-Test Designs

    Science.gov (United States)

    van der Linden, Wim J.; Wiberg, Marie

    2010-01-01

    For traditional methods of observed-score equating with anchor-test designs, such as chain and poststratification equating, it is difficult to satisfy the criteria of equity and population invariance. Their equatings are therefore likely to be biased. The bias in these methods was evaluated against a simple local equating method in which the…

  20. Pasture Condition Score Indicators: Controls on Plant and Forage Diversity

    Science.gov (United States)

    The USDA-NRCS Pasture Condition Score (PCS) system was developed for evaluating pastures and making management recommendations. Four of the ten rating criteria relate to plant species diversity and composition: percent desirable plants, plant cover, plant diversity, and percent legume. Baseline data...

  1. Disease activity score in rheumatoid arthritis with or without secondary fibromyalgia

    International Nuclear Information System (INIS)

    Objective: To correlate disease activity score (DAS-28) in the patients with rheumatoid arthritis (RA) with and without secondary fibromyalgia. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Rheumatology, Pakistan Institute of Medical Sciences, Islamabad, from November 2011 to April 2012. Methodology: Patients aged above 16 years diagnosed to have rheumatoid arthritis according to ACR/EULAR criteria 2010 were included in the study. Fibromyalgia (FM) was diagnosed by ACR 1990 criteria. Patients of other autoimmune diseases or psychiatric illnesses were excluded. DAS was determined and compared using t-test with significance at p < 0.05. Results: The mean age of study subjects was 42.9 years. Thirty one out of total 138 patients had fibromyalgia (22.4%). Female gender was predominant (92.0%); being 96.8% in patients with and in 88.2% without fibromyalgia. The average DAS score was high (5.3 + 1.5) in fibromyalgia patients compared to those without fibromyalgia (3.9 + 1.2); this difference in mean value was statistically significant (p = < 0.001). Conclusion: DAS-28 is a useful tool for assessing rheumatoid arthritis disease status in outpatient setting, however, increased disease activity must be assessed for possible co-existence of fibromyalgia which can spuriously give high DAS value and adversely affect treatment decision. (author)

  2. 2012 provisional classification criteria for polymyalgia rheumatica

    DEFF Research Database (Denmark)

    Dasgupta, Bhaskar; Cimmino, Marco A; Maradit-Kremers, Hilal; Schmidt, Wolfgang A; Schirmer, Michael; Salvarani, Carlo; Bachta, Artur; Dejaco, Christian; Duftner, Christina; Jensen, Hanne Slott; Duhaut, Pierre; Poór, Gyula; Kaposi, Novák Pál; Mandl, Peter; Balint, Peter V; Schmidt, Zsuzsa; Iagnocco, Annamaria; Nannini, Carlotta; Cantini, Fabrizio; Macchioni, Pierluigi; Pipitone, Nicolò; Amo, Montserrat Del; Espígol-Frigolé, Georgina; Cid, Maria C; Martínez-Taboada, Víctor M; Nordborg, Elisabeth; Direskeneli, Haner; Aydin, Sibel Zehra; Ahmed, Khalid; Hazleman, Brian; Silverman, Barbara; Pease, Colin; Wakefield, Richard J; Luqmani, Raashid; Abril, Andy; Michet, Clement J; Marcus, Ralph; Gonter, Neil J; Maz, Mehrdad; Carter, Rickey E; Crowson, Cynthia S; Matteson, Eric L

    2012-01-01

    algorithm was developed based on morning stiffness >45 minutes (2 points), hip pain/limited range of motion (1 point), absence of RF and/or ACPA (2 points), and absence of peripheral joint pain (1 point). A score ?4 had 68% sensitivity and 78% specificity for discriminating all comparison subjects from PMR....... The specificity was higher (88%) for discriminating shoulder conditions from PMR and lower (65%) for discriminating RA from PMR. Adding ultrasound, a score ?5 had increased sensitivity to 66% and specificity to 81%. According to these provisional classification criteria, patients ?50 years old...

  3. 2012 provisional classification criteria for polymyalgia rheumatica

    DEFF Research Database (Denmark)

    Dasgupta, Bhaskar; Cimmino, Marco A; Maradit-Kremers, Hilal; Schmidt, Wolfgang A; Schirmer, Michael; Salvarani, Carlo; Bachta, Artur; Dejaco, Christian; Duftner, Christina; Jensen, Hanne Slott; Duhaut, Pierre; Poór, Gyula; Kaposi, Novák Pál; Mandl, Peter; Balint, Peter V; Schmidt, Zsuzsa; Iagnocco, Annamaria; Nannini, Carlotta; Cantini, Fabrizio; Macchioni, Pierluigi; Pipitone, Nicolò; Amo, Montserrat Del; Espígol-Frigolé, Georgina; Cid, Maria C; Martínez-Taboada, Víctor M; Nordborg, Elisabeth; Direskeneli, Haner; Aydin, Sibel Zehra; Ahmed, Khalid; Hazleman, Brian; Silverman, Barbara; Pease, Colin; Wakefield, Richard J; Luqmani, Raashid; Abril, Andy; Michet, Clement J; Marcus, Ralph; Gonter, Neil J; Maz, Mehrdad; Carter, Rickey E; Crowson, Cynthia S; Matteson, Eric L

    2012-01-01

    The objective of this study was to develop EULAR/ACR classification criteria for polymyalgia rheumatica (PMR). Candidate criteria were evaluated in a 6-month prospective cohort study of 125 patients with new onset PMR and 169 non-PMR comparison subjects with conditions mimicking PMR. A scoring algorithm was developed based on morning stiffness >45 minutes (2 points), hip pain/limited range of motion (1 point), absence of RF and/or ACPA (2 points), and absence of peripheral joint pain (1 point). ...

  4. Correlations between radiographic assessments and MRI features of knee osteoarthritis - a cross sectional study

    DEFF Research Database (Denmark)

    Gudbergsen, Henrik Rindel; Lohmander, Stefan; Jones, Graeme; Christensen, Robin; Bartels, Else Marie; Danneskiold-Samsøe, Bente; Bliddal, Henning; Boesen, Mikael

    2013-01-01

    OBJECTIVES: To assess correlations between Kellgren & Lawrence Gradings (KL), minimum joint space width measurements (mJSW) and the Boston-Leeds Osteoarthritis of the Knee Score (BLOKS) within a cohort of obese patients with knee osteoarthritis (KOA). METHODS: 192 participants were recruited from an outpatient clinic (ClinicalTrials.gov: NCT00655941). Inclusion criteria were age ?50 years, body mass index (BMI) ?30 kg/m(2) plus symptomatic and verified KOA. 1.5 T MRI scans were assessed using BL...

  5. eGrader, A Software Application that Automatically Scores Student Essays: with a Postscript on Ethical Complexities

    Directory of Open Access Journals (Sweden)

    Roxanne Byrne

    2010-12-01

    Full Text Available Online and traditional teachers face several instructional challenges with regard to assessing student learning. This paper focuses on a software application that automatically scores student essay. The first part gives a brief overview of three commercial automated essay scoring systems. Then it describes the technical aspects of the machine grader developed by the authors, including an assessment of its performance. Although the statistical results were significant in finding a strong correlation between human and machine scorers and the other measures, follow-up non-quantitative evaluations led the researchers to discontinue using the eGrader. They concluded that while the eGrader's ability to measure objective evaluation criteria was successful, measuring subjective ideas proved to more complex and problematic.

  6. Credit Scoring Modeling

    Directory of Open Access Journals (Sweden)

    Siana Halim

    2014-01-01

    Full Text Available It is generally easier to predict defaults accurately if a large data set (including defaults is available for estimating the prediction model. This puts not only small banks, which tend to have smaller data sets, at disadvantage. It can also pose a problem for large banks that began to collect their own historical data only recently, or banks that recently introduced a new rating system. We used a Bayesian methodology that enables banks with small data sets to improve their default probability. Another advantage of the Bayesian method is that it provides a natural way for dealing with structural differences between a bank’s internal data and additional, external data. In practice, the true scoring function may differ across the data sets, the small internal data set may contain information that is missing in the larger external data set, or the variables in the two data sets are not exactly the same but related. Bayesian method can handle such kind of problem.

  7. Non-criteria anti-phospholipid antibodies and cognitive impairment in SLE.

    Science.gov (United States)

    Luggen, Michael E; Gulati, Gaurav; Zhang, Bin; Willis, Rohan A; Gonzalez, Emilio B

    2016-01-01

    The pathogenesis of cognitive impairment (CI) in patients with systemic lupus erythematosus (SLE) is unknown. Anti-phospholipid antibodies (APL) have been implicated. The APL which have been evaluated have variably included anti-cardiolipin (ACL) antibodies, lupus anticoagulant (LAC), and antibodies to beta-2 glycoprotein I (?2GPI). Few studies have examined other APL (so-called non-criteria APL). We evaluated the association of CI with a broad spectrum of non-criteria APL. Subjects meeting SLE classification criteria were recruited from three different patient populations. Cognitive function was assessed with the Automated Neuropsychologic Assessment Metrics (ANAM), a validated computer-based assessment tool. The total throughput score (TTS = number of correct responses/time) was used as the primary outcome measure. The following APL of all three isotypes were assessed by ELISA using standardized techniques: anti-?2GPI, anti-phosphatidyl ethanolamine (aPE), anti-phosphatidyl choline (aPC), anti-phosphatidyl inositol (aPI), anti-phosphatidyl serine (aPS), anti-phosphatidyl glycerol (aPG), anti-phosphatidic acid (aPA). Fifty-seven (57) patients were evaluated. Of the 57, 12 had definite CI (>1.5 SD below the mean of an age-, sex-, and race-matched RA population). The two groups were significantly different with regard to age, ethnicity, and family income. There was no significant difference between groups with regard to the presence of any non-criteria APL. When titers of specific non-criteria APL were compared with TTS, no significant correlations were found. Using multiple linear regression and adjusting for relevant covariates including age, ethnicity, and family income, neither the presence nor the titer of any non-criteria APL significantly influenced TTS. In this cross-sectional study, non-criteria APL were not associated with CI. PMID:26563139

  8. Chest computed tomography-based scoring of thoracic sarcoidosis: Inter-rater reliability of CT abnormalities

    International Nuclear Information System (INIS)

    To determine inter-rater reliability of sarcoidosis-related computed tomography (CT) findings that can be used for scoring of thoracic sarcoidosis. CT images of 51 patients with sarcoidosis were scored by five chest radiologists for various abnormal CT findings (22 in total) encountered in thoracic sarcoidosis. Using intra-class correlation coefficient (ICC) analysis, inter-rater reliability was analysed and reported according to the Guidelines for Reporting Reliability and Agreement Studies (GRRAS) criteria. A pre-specified sub-analysis was performed to investigate the effect of training. Scoring was trained in a distinct set of 15 scans in which all abnormal CT findings were represented. Median age of the 51 patients (36 men, 70 %) was 43 years (range 26 - 64 years). All radiographic stages were present in this group. ICC ranged from 0.91 for honeycombing to 0.11 for nodular margin (sharp versus ill-defined). The ICC was above 0.60 in 13 of the 22 abnormal findings. Sub-analysis for the best-trained observers demonstrated an ICC improvement for all abnormal findings and values above 0.60 for 16 of the 22 abnormalities. In our cohort, reliability between raters was acceptable for 16 thoracic sarcoidosis-related abnormal CT findings. (orig.)

  9. Chest computed tomography-based scoring of thoracic sarcoidosis: Inter-rater reliability of CT abnormalities

    Energy Technology Data Exchange (ETDEWEB)

    Heuvel, D.A.V. den; Es, H.W. van; Heesewijk, J.P. van; Spee, M. [St. Antonius Hospital Nieuwegein, Department of Radiology, Nieuwegein (Netherlands); Jong, P.A. de [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Zanen, P.; Grutters, J.C. [University Medical Center Utrecht, Division Heart and Lungs, Utrecht (Netherlands); St. Antonius Hospital Nieuwegein, Center of Interstitial Lung Diseases, Department of Pulmonology, Nieuwegein (Netherlands)

    2015-09-15

    To determine inter-rater reliability of sarcoidosis-related computed tomography (CT) findings that can be used for scoring of thoracic sarcoidosis. CT images of 51 patients with sarcoidosis were scored by five chest radiologists for various abnormal CT findings (22 in total) encountered in thoracic sarcoidosis. Using intra-class correlation coefficient (ICC) analysis, inter-rater reliability was analysed and reported according to the Guidelines for Reporting Reliability and Agreement Studies (GRRAS) criteria. A pre-specified sub-analysis was performed to investigate the effect of training. Scoring was trained in a distinct set of 15 scans in which all abnormal CT findings were represented. Median age of the 51 patients (36 men, 70 %) was 43 years (range 26 - 64 years). All radiographic stages were present in this group. ICC ranged from 0.91 for honeycombing to 0.11 for nodular margin (sharp versus ill-defined). The ICC was above 0.60 in 13 of the 22 abnormal findings. Sub-analysis for the best-trained observers demonstrated an ICC improvement for all abnormal findings and values above 0.60 for 16 of the 22 abnormalities. In our cohort, reliability between raters was acceptable for 16 thoracic sarcoidosis-related abnormal CT findings. (orig.)

  10. Tear Osmolarity, Break-up Time and Schirmer’s Scores in Parkinson’s Disease

    Directory of Open Access Journals (Sweden)

    Esin Sö?ütlü Sar?

    2015-08-01

    Full Text Available Objectives: Dry eye is an important problem in Parkinson’s disease (PD with a potential to affect life quality. Tear osmolarity, accepted as the gold standard in dry eye diagnosis, has not been studied in this subset of patients so far. Therefore, in this study we aimed to evaluate tear osmolarity, Schirmer’s test scores and tear film break-up time (TBUT in PD patients. Materials and Methods: PD patients with a minimum follow-up of 1 year and healthy controls who admitted for refractive abnormalities were enrolled to the study. Subjects using any systemic medication with a possibility to affect tear tests were not included in the study. The presence of any ocular surface disorder, previous ocular surgery, previous dry eye diagnosis, any topical ophthalmic medication or contact lens use were other exclusion criteria. Age, gender, disease duration, and Hoehn and Yahr (H&Y score for disease severity were noted, and blink rate (BR, Schirmer’s test score, TBUT and tear osmolarity of the right eye were measured in both groups. Results: Thirty-seven PD patients and 37 controls were enrolled to the study. The groups were age and gender matched. The mean disease duration and H&Y score were 5.70±2.64 years and 1.70±0.93, respectively. H&Y staging and disease duration were not correlated to BR, Schirmer’s scores, TBUT, or tear osmolarity (p>0.05. The mean BR was 8.54±4.99 blinks/minute in PD patients and 11.97±6.36 blinks/minute in the control group. Mean Schirmer’s scores, TBUT and osmolarity values were 9.08±4.46 mm, 11.38±4.05 seconds and 306.43±12.63 mOsm/L in the PD group and 17.16±9.57 mm, 12.81±3.66 seconds and 303.81±16.13 mOsm/L in the control group. The differences were significant only in BR and Schirmer’s scores. Conclusion: BR and Schirmer’s scores decreased significantly in PD patients. Although not significant, the demonstrated tear osmolarity increment might be important to document the dry eye and inflammatory process of the ocular surface in PD patients. (Turk J Ophthalmol 2015; 45: 142-145

  11. Grado de correlación en la percepción de la dinámica familiar entre ambos padres de preescolares que acuden a Guarderías del DIF Jalisco / Correlation of the family dinamic score between fathers and mothers of preschool children attending the integral development of the family system (DIF) of Guadalajara, Jalisco (Mexico)

    Scientific Electronic Library Online (English)

    Francisco, Nápoles-Rodríguez; Angélica, Cevallos-González; Eva, Sánchez-Talamantes; José Luis, González-Rico; Enrique, Romero-Velarde; Edgar M., Vásquez-Garibay.

    2005-06-01

    Full Text Available Introducción. Objetivo: identificar la correlación entre la calificación de dinámica familiar de papá y mamá de preescolares que acuden a Guarderías del Sistema Nacional del Desarrollo Integral de la Familia Jalisco. Material y métodos. Estudio transversal analítico. Se incluyeron 138 encuestas de d [...] inámica familiar aplicadas a ambos padres. Se utilizó un instrumento de medición con 8 áreas: I. Dinámica de pareja; II. Formación de identidad; III. Comunicación, expresión, solidaridad; IV. Estructura de autoridad; V. Manejo del conflicto y agresividad;VI. Disciplina y método; VII. Sistema de Valores; VIII.Aislamiento e integración sociocultural. Resultados. No hubo diferencia en la calificación entre ambos padres ni entre los promedios de las 8 áreas. Hubo una correlación significativa entre ambos padres (r = 0.759, P Abstract in english Introduction. Objective: to test the correlation of the family dynamic score between fathers and mothers of preschool children attending the Integral Development of the Family System (DIF) of Guadalajara City. Material and methods. In a cross sectional study design 140 family dynamic surveys were in [...] cluded. Eight areas of the dynamic of the family of both parents were explored: I. Dynamic of the couple; II. Formation of identity; III. Communication, expression and solidarity; IV. Structure of the authority;V. Management of the conflict and aggressiveness;VI. Discipline and method;VII. System of values;VIII. Socio cultural integration and isolation. Results. There were not differences between fathers and mothers in the eight explored areas.The score of fathers and mothers had a significant correlation (r =0.759). Area I had the higher correlation with the rest of the areas (P

  12. Rethinking Convenience Sampling: Defining Quality Criteria

    OpenAIRE

    Farahman Farrokhi; Asgar Mahmoudi-Hamidabad

    2012-01-01

    Convenience sampling is one of the most commonly used sampling procedures in second language acquisition studies, but this non-random sampling procedure suffers from a lot of problems including the inability of controlling for initial differences between experimental and control groups. The present study tries to introduce conditions and criteria which enable researchers to account for these drawbacks and at the same time make validity claims. Individual scores and group statistics are compar...

  13. Association between value-based purchasing score and hospital characteristics

    Directory of Open Access Journals (Sweden)

    Borah Bijan J

    2012-12-01

    Full Text Available Abstract Background Medicare hospital Value-based purchasing (VBP program that links Medicare payments to quality of care will become effective from 2013. It is unclear whether specific hospital characteristics are associated with a hospital’s VBP score, and consequently incentive payments. The objective of the study was to assess the association of hospital characteristics with (i the mean VBP score, and (ii specific percentiles of the VBP score distribution. The secondary objective was to quantify the associations of hospital characteristics with the VBP score components: clinical process of care (CPC score and patient satisfaction score. Methods Observational analysis that used data from three sources: Medicare Hospital Compare Database, American Hospital Association 2010 Annual Survey and Medicare Impact File. The final study sample included 2,491 U.S. acute care hospitals eligible for the VBP program. The association of hospital characteristics with the mean VBP score and specific VBP score percentiles were assessed by ordinary least square (OLS regression and quantile regression (QR, respectively. Results VBP score had substantial variations, with mean score of 30 and 60 in the first and fourth quartiles of the VBP score distribution. For-profit status (vs. non-profit, smaller bed size (vs. 100–199 beds, East South Central region (vs. New England region and the report of specific CPC measures (discharge instructions, timely provision of antibiotics and beta blockers, and serum glucose controls in cardiac surgery patients were positively associated with mean VBP scores (p Conclusions Although hospitals serving the poor and the elderly are more likely to score lower under the VBP program, the correlation appears small. Profit status, geographic regions, number and type of CPC measures reported explain the most variation among scores.

  14. Propensity score matching in SPSS

    OpenAIRE

    Thoemmes, Felix

    2012-01-01

    Propensity score matching is a tool for causal inference in non-randomized studies that allows for conditioning on large sets of covariates. The use of propensity scores in the social sciences is currently experiencing a tremendous increase; however it is far from a commonly used tool. One impediment towards a more wide-spread use of propensity score methods is the reliance on specialized software, because many social scientists still use SPSS as their main analysis tool. Th...

  15. Cardiovascular risk scores do not account for the effect of treatment: a review

    OpenAIRE

    Liew, SM; Doust, J; Glasziou, P

    2011-01-01

    OBJECTIVE: To compare the strengths and limitations of cardiovascular risk scores available for clinicians in assessing the global (absolute) risk of cardiovascular disease. DESIGN: Review of cardiovascular risk scores. DATA SOURCES: Medline (1966 to May 2009) using a mixture of MeSH terms and free text for the keywords 'cardiovascular', 'risk prediction' and 'cohort studies'. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: A study was eligible if it fulfilled the following criteria: (1) it was a...

  16. Do medical students’ scores using different assessment instruments predict their scores in clinical reasoning using a computer-based simulation?

    Science.gov (United States)

    Fida, Mariam; Kassab, Salah Eldin

    2015-01-01

    Purpose The development of clinical problem-solving skills evolves over time and requires structured training and background knowledge. Computer-based case simulations (CCS) have been used for teaching and assessment of clinical reasoning skills. However, previous studies examining the psychometric properties of CCS as an assessment tool have been controversial. Furthermore, studies reporting the integration of CCS into problem-based medical curricula have been limited. Methods This study examined the psychometric properties of using CCS software (DxR Clinician) for assessment of medical students (n=130) studying in a problem-based, integrated multisystem module (Unit IX) during the academic year 2011–2012. Internal consistency reliability of CCS scores was calculated using Cronbach’s alpha statistics. The relationships between students’ scores in CCS components (clinical reasoning, diagnostic performance, and patient management) and their scores in other examination tools at the end of the unit including multiple-choice questions, short-answer questions, objective structured clinical examination (OSCE), and real patient encounters were analyzed using stepwise hierarchical linear regression. Results Internal consistency reliability of CCS scores was high (?=0.862). Inter-item correlations between students’ scores in different CCS components and their scores in CCS and other test items were statistically significant. Regression analysis indicated that OSCE scores predicted 32.7% and 35.1% of the variance in clinical reasoning and patient management scores, respectively (P<0.01). Multiple-choice question scores, however, predicted only 15.4% of the variance in diagnostic performance scores (P<0.01), while students’ scores in real patient encounters did not predict any of the CCS scores. Conclusion Students’ scores in OSCE are the most important predictors of their scores in clinical reasoning and patient management using CCS. However, real patient encounter assessment does not appear to test a construct similar to what is tested in CCS. PMID:25759603

  17. A scoring system for the assessment of angiographic findings in non-occlusive mesenteric ischemia (NOMI)

    International Nuclear Information System (INIS)

    Purpose: To establish a standardized scoring system for angiographic findings in patients with non-occlusive mesenteric ischemia (NOMI). Materials and Methods: In 36 patients (mean age: 72 years), 53 angiographies of the superior mesenteric artery (SMA) were performed for suspected NOMI after cardiac or major aortic surgery. All examinations were performed using a standardized DSA technique. Two experienced radiologists performed a consensus reading blinded to the clinical information, on two occasions with an interval of two weeks. In order to investigate the reproducibility of the criteria, the images were assessed once by an intensivist and a medical student. Image analysis was performed with respect to vessel morphology, reflux of contrast medium into the aorta, small bowel parenchymal contrast enhancement and distension and the delay between arterial injection and portal vein filling. Results: Almost perfect intra-observer correlation was obtained for the assessment of the contrast medium reflux (? = 0.82) and substantial correlation for the time of portal vein filling (? = 0.66). Moderate correlations were obtained for the vessel morphology (? = 0.51), small bowel enhancement (? = 0.63) and distension (? = 0.53). Contrast medium reflux into the aorta (? = 0.77 and 0.63) and the time of portal vein filling (? = 0.42 and 0.58) resulted in the highest inter-observer correlations between the radiologists and the intensivist as well as the radiologists and the student. Conclusion: In patients with suspected NOMI, using our scoring system yields high intra- and inter-observer correlations, allowing a standardized evaluation of angiographic findings. (orig.)

  18. Repository operational criteria analysis

    International Nuclear Information System (INIS)

    The objective of the ''Repository Operational Criteria (ROC) Feasibility Studies'' (or ROC task) was to conduct comprehensive and integrated analyses of repository design, construction, and operations criteria in 10 CFR Part 60 regulations, considering the interfaces and impacts of any potential changes to those regulations. The study addresses regulatory criteria related to the preclosure aspects of the geologic repository. The study task developed regulatory concepts or potential repository operational criteria (PROC) based on analysis of a repository's safety functions and other regulations for similar facilities. These regulatory concepts or PROC were used as a basis to assess the sufficiency and adequacy of the current criteria in 10 CFR Part 60. Where the regulatory concepts were same as current operational criteria, these criteria were referenced. The operations criteria referenced or the PROC developed are given in this report. Detailed analyses used to develop the regulatory concepts and any necessary PROC for those regulations that may require a minor change are also presented. The results of the ROC task showed a need for further analysis and possible major rule change related to the design bases of a geologic repository operations area, siting, and radiological emergency planning

  19. What is healthy food? Objective nutrient profile scores and subjective lay evaluations in comparison.

    Science.gov (United States)

    Bucher, T; Müller, B; Siegrist, M

    2015-12-01

    To date, it is unclear how consumers evaluate the healthiness of individual foods and meals and how consumers' perceptions are related to expert opinions. This knowledge is essential for efficient communication of nutrition information with the goal of promoting healthy eating. This study used the fake food buffet method to investigate health perceptions of selected meals and of 54 individual foods and beverages. Lay consumers' subjective healthiness evaluations of meals and foods were compared to objective nutrient profile scores, which were previously shown to correlate highly with expert opinions. The results show that nutrition profile scores and lay evaluations were highly correlated, which indicates that lay people used similar criteria as experts to evaluate the healthiness of foods. However, lay consumers tended to neglect the amount of saturated fat, protein and sodium for their judgments. Also, it was found that while lay consumers were quite able to evaluate single food products, they had difficulties in evaluating entire meals. Future interventions should focus particularly on educating the consumer about the negative effects of diets high in salt and saturated fat and they should improve the consumer's abilities to evaluate entire meals. PMID:26256557

  20. Plutonium storage criteria

    Energy Technology Data Exchange (ETDEWEB)

    Chung, D. [Scientech, Inc., Germantown, MD (United States); Ascanio, X. [Dept. of Energy, Germantown, MD (United States)

    1996-05-01

    The Department of Energy has issued a technical standard for long-term (>50 years) storage and will soon issue a criteria document for interim (<20 years) storage of plutonium materials. The long-term technical standard, {open_quotes}Criteria for Safe Storage of Plutonium Metals and Oxides,{close_quotes} addresses the requirements for storing metals and oxides with greater than 50 wt % plutonium. It calls for a standardized package that meets both off-site transportation requirements, as well as remote handling requirements from future storage facilities. The interim criteria document, {open_quotes}Criteria for Interim Safe Storage of Plutonium-Bearing Solid Materials{close_quotes}, addresses requirements for storing materials with less than 50 wt% plutonium. The interim criteria document assumes the materials will be stored on existing sites, and existing facilities and equipment will be used for repackaging to improve the margin of safety.

  1. Trends in Classroom Observation Scores

    Science.gov (United States)

    Casabianca, Jodi M.; Lockwood, J. R.; McCaffrey, Daniel F.

    2015-01-01

    Observations and ratings of classroom teaching and interactions collected over time are susceptible to trends in both the quality of instruction and rater behavior. These trends have potential implications for inferences about teaching and for study design. We use scores on the Classroom Assessment Scoring System-Secondary (CLASS-S) protocol from…

  2. Classification of current scoring functions.

    Science.gov (United States)

    Liu, Jie; Wang, Renxiao

    2015-03-23

    Scoring functions are a class of computational methods widely applied in structure-based drug design for evaluating protein-ligand interactions. Dozens of scoring functions have been published since the early 1990s. In literature, scoring functions are typically classified as force-field-based, empirical, and knowledge-based. This classification scheme has been quoted for more than a decade and is still repeatedly quoted by some recent publications. Unfortunately, it does not reflect the recent progress in this field. Besides, the naming convention used for describing different types of scoring functions has been somewhat jumbled in literature, which could be confusing for newcomers to this field. Here, we express our viewpoint on an up-to-date classification scheme and appropriate naming convention for current scoring functions. We propose that they can be classified into physics-based methods, empirical scoring functions, knowledge-based potentials, and descriptor-based scoring functions. We also outline the major difference and connections between different categories of scoring functions. PMID:25647463

  3. Evidence-based provisional clinical classification criteria for autoinflammatory periodic fevers

    DEFF Research Database (Denmark)

    Federici, Silvia; Sormani, Maria Pia

    2015-01-01

    The objective of this work was to develop and validate a set of clinical criteria for the classification of patients affected by periodic fevers. Patients with inherited periodic fevers (familial Mediterranean fever (FMF); mevalonate kinase deficiency (MKD); tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS); cryopyrin-associated periodic syndromes (CAPS)) enrolled in the Eurofever Registry up until March 2013 were evaluated. Patients with periodic fever, aphthosis, pharyngitis and adenitis (PFAPA) syndrome were used as negative controls. For each genetic disease, patients were considered to be 'gold standard' on the basis of the presence of a confirmatory genetic analysis. Clinical criteria were formulated on the basis of univariate and multivariate analysis in an initial group of patients (training set) and validated in an independent set of patients (validation set). A total of 1215 consecutive patients with periodic fevers were identified, and 518 gold standard patients (291 FMF, 74 MKD, 86 TRAPS, 67 CAPS) and 199 patients with PFAPA as disease controls were evaluated. The univariate and multivariate analyses identified a number of clinical variables that correlated independently with each disease, and four provisional classification scores were created. Cut-off values of the classification scores were chosen using receiver operating characteristic curve analysis as those giving the highest sensitivity and specificity. The classification scores were then tested in an independent set of patients (validation set) with an area under the curve of 0.98 for FMF, 0.95 for TRAPS, 0.96 for MKD, and 0.99 for CAPS. In conclusion, evidence-based provisional clinical criteria with high sensitivity and specificity for the clinical classification of patients with inherited periodic fevers have been developed.

  4. 2011 Yılı Yönetici Atama ve Yer Değiştirme Yönetmeği’nin İçeriğine ve Puanlama Ölçütlerine İlişkin Yönetici Görüşlerinin İncelenmesi Investigation of Manager Opinions on the Content and Scoring Criteria of the 2011 Manager Appointment and Rotation Regulations

    Directory of Open Access Journals (Sweden)

    Selçuk Beşir DEMİR

    2013-07-01

    Full Text Available Purpose: This study aims at determining the opinions of managersrelating to the Manager Appointment and Rotation Regulations dated2011, the scoring criteria included in the regulations and the troublesexperienced throughout the implementation process of the regulations.Method: In this research, a qualitative approach was adopted sothat the issue can be examined thoroughly. In this research, thephenomenological pattern was employed. In the research, participantswere determined by way of sampling for maximum diversity-one of theintentional sampling methods. The study group of the research consistsof 8 managers holding Office in the city X (pseudonym. Terms of Officeof the participants varies between 25 and 8 years. Semi-structuredinterview form was used as data collection tools in the research. All theinterviews were recorded on a tape recorder throughout the research. A240-minute interview was had within the scope of the research; the taperecording was computerized through the Microsoft Word processingprogram as raw data without being subjected to any screening.Line by line analysis described by Patton, (2002 was employed todescribe opinions expressed clearly and directly or implied in anindirect manner by the participants on the aim of the study withoutmanipulating them. Inductive descriptive analysis, content analysis andthe constant comparison technique was used in the interpretation ofthe interview data. The descriptive analysis project is made up of fourmain stages, namely, building up the thematic framework, processingdata according to the thematic framework, identifying the findings andinterpreting the findings.During content analysis, on the other hand, the data was dividedinto parts first and then these parts were investigated and compared.Later, meaningful concepts were built from these parts and the codesevoking the same concepts were grouped under a joint category. In thefinal stage, content integrity was derived from the themes stemmingfrom the data and interpreted.While developing an interview form, a conceptual frameworkrelating to the subject matter was formed by investigating the relatedbody of literature for the purposes of increasing credibility/ internalvalidity of the research. Each stage of the research process wasprovided to the reader in a detailed manner so that thetransferability/external validity of the research could be insured. Theresearcher has watched over to write his research report in detail andtried to present detailed descriptions in the findings part.All the data obtained throughout the research process wasevaluated and separately coded by the researcher and an instructor,who has a command of qualitative research methods and a consensuswas reached on the codings in general terms. Results: As a result of analysis of the data, three main subjects, namely, 1. Evaluations relating to the appointment and change of Office of managers, 2. Evaluations relating to the content of the Manager Appointment and Change of Office Regulations and to the scoring principles, 3. Evaluations relating to compulsory rotation appeared.As a result of the story, it was concluded that the belief that the awards (certificates of appreciation and high achievement granted by the Ministry of National Education central organization and provincial organizations and by the related civilian authority are not offered based on merits, justice and qualification and in line with objective criteria dominated the participants and based on this idea, they had the idea that scoring of these awards in the manager appointment process may lead to unfair competition and injustice.It was found out in the study that the participants objected not to the scoring of the awards in the appointment of manager; just to the contrary, they argued against the scoring of these awards in the manager appointment process based on the idea that the awards granted were not given according to objective criteria.It was observed that the participants believing that there is a relationship between the term of Office and experience and specialization in management and that experience makes positive contributions to the school management did not protest against the scoring of their terms of Office within the framework of the regulations but that some participants, who have been teaching for a long period of time or are acting as managers by Proxy have reservations in regard to losing their dynamism.It was determined that the participants did not oppose to the practice of expert and head teachers’ being given additional points within the scope of Manager Appointment and Rotation Regulations but they thought that applicants that are entitled to become an expert or head teacher but cannot become an expert or head teacher due to the restrictions introduced by the regulations in question suffer in the manager appointment and rotation process.Discussion and Conclusion: In the light of the findings obtained as a result of this study, it is possible to say that although troubles were experienced during the implementation of the 2011 Manager Appointment and Rotation Regulations, the implementation is supported in general; that attempts are being made at avoiding influential contacts and favoritism by bounding the manager appointment process by criteria that can be accepted as objective, thanks to the regulations; that manager appointment carried out taking point average into consideration makes appointment of applicants, who can be considered as qualified, possible. According to the study, it can be reported that the scoring criteria in the Manager Appointment and Rotation Regulations are considered to be objective and acceptable by the participants. However, it is obvious that awarding, troubles experienced during the transfer procedures between the career steps of teachers and additional points given to Founding Directors hinders the manager appointment process. Bu çalışmada; 2011 tarihli Yönetici Atama ve Yer Değiştirme Yönetmeliği’ne, yönetmelikte yer alan puanlama ölçütlerine ve yönetmeliğin uygulanışı sürecinde yaşanan aksaklıklara ilişkin kurum yöneticilerinin görüşlerinin belirlenmesi amaçlanmıştır. Çalışma, nitel araştırma yöntemleriyle, olgubilim desenine uygun olarak yürütülmüştür. Araştırmada, katılımcılar amaçlı örnekleme yöntemlerinden maksimum çeşitlilik örneklemesi ile belirlenmiştir. Araştırmanın çalışma grubu; (rumuz ilinde görev yapan 8 yöneticiden oluşmaktadır. Araştırmada, veri toplama aracı olarak; yarı yapılandırılmış görüşme formu kullanılmıştır. Araştırma sürecinde tüm görüşmeler ses kayıt cihazıyla kayıt altına alınmıştır. Araştırma kapsamında 240 dakikalık görüşme yapılmış, ses kayıtları herhangi bir elemeye tabi tutulmadan, ham veri olarak Microsoft Word programına aktarılmıştır. Araştırmada her bir transkrip, satır-satır analiz (line by line analysis yaklaşımı kullanılarak analiz edilmiştir. Görüşme verilerinin yorumlanması sürecinde endüktif (inductive betimsel analiz, içerik analizi ve sürekli karşılaştırma tekniği (constant comparison kullanılmıştır. Verilerin analizi sonucu; 1. Yönetici atama ve yer değiştirme sürecine ilişkin değerlendirmeler, 2. Yönetici Atama ve Yer Değiştirme Yönetmeliği’nin içeriğine ve puanlama esaslarına ilişkin değerlendirmeler, 3. Zorunlu yer değiştirme (rotasyon uygulamasına ilişkin değerlendirmeler olmak üzere üç ana tema ortaya çıkmıştır.

  5. Fire protection design criteria

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    This Standard provides supplemental fire protection guidance applicable to the design and construction of DOE facilities and site features (such as water distribution systems) that are also provided for fire protection. It is intended to be used in conjunction with the applicable building code, national Fire Protection Association Codes and Standards, and any other applicable DOE construction criteria. This Standard, along with other delineated criteria, constitutes the basic criteria for satisfying DOE fire and life safety objectives for the design and construction or renovation of DOE facilities.

  6. The Relationship between Admission Criteria and Fieldwork Performance in a Masters-Level OT Program: Implications for Admissions

    Directory of Open Access Journals (Sweden)

    Molly Bathje MS, OTR/L

    2014-07-01

    Full Text Available Occupational therapy (OT graduate programs strive to produce an effective OT workforce with competent and engaged OT practitioners. Admission into OT graduate programs is an increasingly competitive process, with most programs having more applicants than spaces available. Programs need to select applicants that will be the most successful in meeting graduation requirements, including both academic and clinical components. This pilot study was designed to examine the relationship between admission criteria and fieldwork (FW performance. The study utilized a retrospective analysis with a convenience sample of 108 students with complete data from a private university in the Midwest. Independent variables of Graduate Record Examination (GRE subscale scores (GRE-verbal, GRE-quantitative, and GRE-written and undergraduate Cumulative Grade Point Average (CGPA were included. The dependent variable was level II FW performance, as measured by the AOTA Fieldwork Performance Evaluation (FWPE. Results of this study found a significant correlation between CGPA and FWPE scores for level IIA FW experiences, and a significant correlation between GRE-written and FWPE scores for level IIB FW experiences. Regression models for FW IIB indicated that GRE-written was a significant predictor of FWPE scores for the FW IIB experience. This pilot study provides information that may be utilized during OT admission processes.

  7. Unified EEG terminology and criteria for nonconvulsive status epilepticus

    DEFF Research Database (Denmark)

    Beniczky, Sándor; Hirsch, Lawrence J

    2013-01-01

    The diagnosis of nonconvulsive status epilepticus (NCSE) relies largely on electroencephalography (EEG) findings. The lack of a unified EEG terminology, and of evidence-based EEG criteria, leads to varying criteria for and ability to diagnose NCSE. We propose a unified terminology and classification system for NCSE, using, as a template, the Standardised Computer-based Organised Reporting of EEG (SCORE). This approach integrates the terminology recently proposed for the rhythmic and periodic patterns in critically ill patients, the electroclinical classification of NCSE (type of NCSE) and the context for the pathologic conditions and age-related epilepsy syndromes. We propose flexible EEG criteria that employ the SCORE system to assemble a database for determining evidence-based EEG criteria for NCSE.

  8. Classification criteria for spondyloarthropathies

    Directory of Open Access Journals (Sweden)

    Ozgur Akgul

    2011-01-01

    Full Text Available Spondyloarthropathies (SpA are a group of inflammatory arthritis which consist of ankylosing spondylitis (AS, reactive arthritis, arthritis/spondylitis associated with psoriasis (PsA, and arthritis/spondylitis associated with inflammatory bowel diseases. It is now more important than ever to diagnose and treat SpA early. New therapeutic agents including blockers of tumor necrosis factor have yielded tremendous responses not only in advanced disease but also in the early stages of the disease. Sacroiliitis on conventional radiography is the result of structural changes which may appear late in the disease process. However, magnetic resonance imaging (MRI can visualize active inflammation at sacroiliac joints and spine in recent onset disease. The modified New York criteria, the European Spondyloarthropathy Study Group criteria and the Amor criteria do not include advanced imaging techniques like MRI which is very sensitive to the early Inflammatory changes. Assessment of SpondyloArthritis international Society has defined MRI methods for the assessment of sacroiliac joints and spine, criteria for inflammatory back pain and developed new criteria for classification of axial and peripheral spondyloarthritis. These new criteria are intended to be used for patients with SpA at the very early stage of their disease. Also, classification of psoriatic arthritis study group developed criteria for the classification of PsA. The widespread use of these criteria in clinical trials will provide evidence for a better definition of early disease and recognize many patients who may further develop classical AS or PsA. These efforts will guide therapeutic trials of potent drugs like biological agents in the early stage of these diseases.

  9. Meteor Stream Membership Criteria

    OpenAIRE

    Klacka, Jozef

    2000-01-01

    Criteria for the membership of individual meteors in meteor streams are discussed from the point of view of their mathematical and also physical properties. Discussion is also devoted to the motivation. It is shown that standardly used criteria (mainly D-criterion of Southworth and Hawkins, 1963) have unusual mathematical properties in the sense of a term ``distance'', between points in a phase space, and, physical motivation and realization for the purpose of obtaining their final form is no...

  10. Influence of low-stress handling on reactivity score and pregnancy rate during fixed-time artificial insemination in Nellore cows

    Scientific Electronic Library Online (English)

    Rayf Roberto, Tirloni; Fábio Alcântara, Rocha; Fábio José, Lourenço; Lílian Rigatto, Martins.

    2013-07-01

    Full Text Available The objective of this work was to evaluate the influence of low-stress handling (LSH) on reactivity score and pregnancy rate during fixed-time artificial insemination (FTAI) for extensively raised Nellore cows. Multiparous cows (n = 126) were randomly allocated into two groups: G1 (n = 66) and G2, t [...] he control group (n = 60). Group G1 was subjected to LSH, in which the animals were handled in a calm and quiet manner, without loud noises or physical aggression, using the point of balance, respecting the flight zone and using flags to supplement handling. Group G2 was handled following the typical procedure, with yelling, kicking and the use of electric prods and sticks. On D0, D8 and D10, FTAI was performed in both groups. Reactivity was scored on D0, D8 and D10 at the squeeze chute, based on the tension score, breathing score, and bellowing score. Using the three criteria above, the reactivity scores were defined as follows: R1 (calm); R2 (slightly reactive); R3 (moderately reactive); R4 (reactive); and R5 (highly reactive). Thirty-five days after artificial insemination, pregnancy was determined using ultrasonography. There was no significant correlation between reactivity score and pregnancy rate in each group or between the pregnancy rates in both groups. However, there was a statistically significant difference between the G1 and G2 groups with regard to reactivity score (1.62±0.05 vs. 2.12±0.07). Low-stress handling influenced reactivity but did not affect pregnancy rate in extensively raised Nellore cows subjected to FTAI.

  11. Influence of low-stress handling on reactivity score and pregnancy rate during fixed-time artificial insemination in Nellore cows

    Directory of Open Access Journals (Sweden)

    Rayf Roberto Tirloni

    2013-07-01

    Full Text Available The objective of this work was to evaluate the influence of low-stress handling (LSH on reactivity score and pregnancy rate during fixed-time artificial insemination (FTAI for extensively raised Nellore cows. Multiparous cows (n = 126 were randomly allocated into two groups: G1 (n = 66 and G2, the control group (n = 60. Group G1 was subjected to LSH, in which the animals were handled in a calm and quiet manner, without loud noises or physical aggression, using the point of balance, respecting the flight zone and using flags to supplement handling. Group G2 was handled following the typical procedure, with yelling, kicking and the use of electric prods and sticks. On D0, D8 and D10, FTAI was performed in both groups. Reactivity was scored on D0, D8 and D10 at the squeeze chute, based on the tension score, breathing score, and bellowing score. Using the three criteria above, the reactivity scores were defined as follows: R1 (calm; R2 (slightly reactive; R3 (moderately reactive; R4 (reactive; and R5 (highly reactive. Thirty-five days after artificial insemination, pregnancy was determined using ultrasonography. There was no significant correlation between reactivity score and pregnancy rate in each group or between the pregnancy rates in both groups. However, there was a statistically significant difference between the G1 and G2 groups with regard to reactivity score (1.62±0.05 vs. 2.12±0.07. Low-stress handling influenced reactivity but did not affect pregnancy rate in extensively raised Nellore cows subjected to FTAI.

  12. Disease Severity Indexes and Treatment Evaluation Criteria in Vitiligo

    OpenAIRE

    Tamihiro Kawakami; Takashi Hashimoto

    2011-01-01

    There is a current lack of consensus regarding methods of assessment of vitiligo. Recently, the Vitiligo Area Scoring Index (VASI) and the Vitiligo European Task Force (VETF) were proposed to offer more accurate measures of disease severity indexes and treatment evaluation criteria. It would make sense to combine the VASI with the VETF system. We proposed an original scale for treatment evaluation criteria in vitiligo based on VASI. We plan to add the digital image analysis system, health-rel...

  13. piano_prosthesis: indicative score

    OpenAIRE

    Young, Michael W

    2009-01-01

    This score can be used as a creative starting point, as a open-form score that defines all materials you use, or ignored. The overall aim is to establish clearly differentiated musical materials, characterised by pitch, loudness, density, rhythmic activity, sustained-ness and the degree of internal variation (within a timeframe of 10-20 sec.) Having decided upon materials, either in advance or during the performance, the improvisation should focus on recalling and varying these types. Sile...

  14. Image scoring in great apes.

    OpenAIRE

    Russell, YI; Call, J.; Dunbar, RI

    2008-01-01

    'Image scoring' occurs when person A monitors the giving behaviour of person B towards person C. We tested for 'image scoring' in chimpanzees, bonobos, gorillas, and orangutans. Subjects passively observed two types of incident: (i) a 'nice' person gave grapes to a human beggar, and (ii) a 'nasty' person refused to give. The subject witnessed both incidents in succession (but was unable to obtain the grapes). Shortly after, the ape had an opportunity to approach one or both human actors (nice...

  15. Neurointerventional Treatment in Acute Stroke. Whom to Treat? (Endovascular Treatment for Acute Stroke: Utility of THRIVE Score and HIAT Score for Patient Selection)

    Energy Technology Data Exchange (ETDEWEB)

    Fjetland, Lars, E-mail: lars.fjetland@lyse.net; Roy, Sumit, E-mail: sumit.roy@sus.no; Kurz, Kathinka D., E-mail: kathinka.dehli.kurz@sus.no [Stavanger University Hospital, Department of Radiology (Norway); Solbakken, Tore, E-mail: tore.solbakken@sus.no [Stavanger University Hospital, Department of Neurology (Norway); Larsen, Jan Petter, E-mail: jan.petter.larsen@sus.no; Kurz, Martin W., E-mail: martin.kurz@sus.no [The Norwegian Center for Movement Disorders, Stavanger University Hospital (Norway)

    2013-10-15

    Purpose: Intra-arterial therapy (IAT) is used increasingly as a treatment option for acute stroke caused by central large vessel occlusions. Despite high rates of recanalization, the clinical outcome is highly variable. The authors evaluated the Houston IAT (HIAT) and the totaled health risks in vascular events (THRIVE) score, two predicting scores designed to identify patients likely to benefit from IAT. Methods: Fifty-two patients treated at the Stavanger University Hospital with IAT from May 2009 to June 2012 were included in this study. We combined the scores in an additional analysis. We also performed an additional analysis according to high age and evaluated the scores in respect of technical efficacy. Results: Fifty-two patients were evaluated by the THRIVE score and 51 by the HIAT score. We found a strong correlation between the level of predicted risk and the actual clinical outcome (THRIVE p = 0.002, HIAT p = 0.003). The correlations were limited to patients successfully recanalized and to patients <80 years. By combining the scores additional 14.3 % of the patients could be identified as poor candidates for IAT. Both scores were insufficient to identify patients with a good clinical outcome. Conclusions: Both scores showed a strong correlation to poor clinical outcome in patients <80 years. The specificity of the scores could be enhanced by combining them. Both scores were insufficient to identify patients with a good clinical outcome and showed no association to clinical outcome in patients aged {>=}80 years.

  16. Neurointerventional Treatment in Acute Stroke. Whom to Treat? (Endovascular Treatment for Acute Stroke: Utility of THRIVE Score and HIAT Score for Patient Selection)

    International Nuclear Information System (INIS)

    Purpose: Intra-arterial therapy (IAT) is used increasingly as a treatment option for acute stroke caused by central large vessel occlusions. Despite high rates of recanalization, the clinical outcome is highly variable. The authors evaluated the Houston IAT (HIAT) and the totaled health risks in vascular events (THRIVE) score, two predicting scores designed to identify patients likely to benefit from IAT. Methods: Fifty-two patients treated at the Stavanger University Hospital with IAT from May 2009 to June 2012 were included in this study. We combined the scores in an additional analysis. We also performed an additional analysis according to high age and evaluated the scores in respect of technical efficacy. Results: Fifty-two patients were evaluated by the THRIVE score and 51 by the HIAT score. We found a strong correlation between the level of predicted risk and the actual clinical outcome (THRIVE p = 0.002, HIAT p = 0.003). The correlations were limited to patients successfully recanalized and to patients <80 years. By combining the scores additional 14.3 % of the patients could be identified as poor candidates for IAT. Both scores were insufficient to identify patients with a good clinical outcome. Conclusions: Both scores showed a strong correlation to poor clinical outcome in patients <80 years. The specificity of the scores could be enhanced by combining them. Both scores were insufficient to identify patients with a good clinical outcome and showed no association to clinical outcome in patients aged ?80 years

  17. Data Mining the University: College GPA Predictions from SAT Scores

    OpenAIRE

    Hsu, Stephen D H; Schombert, James

    2010-01-01

    We analyze a data set comprised of academic records of undergraduates at the University of Oregon from 2000-2004. We find correlations of roughly 0.35 to 0.5 between SAT scores and upper division, in-major GPA (henceforth, GPA). Interestingly, low SAT scores do not preclude high performance in most majors. That is, the distribution of SAT scores after conditioning on high GPA (e.g., 3.5 or even 4.0) typically extends below 1000 (the average among test takers). We hypothesize...

  18. The Inter-rater Reliability in Scoring Composition

    OpenAIRE

    Ping Wang

    2009-01-01

    This paper makes a study of the rater reliability in scoring composition in the test of English as a foreign language (EFL) and focuses on the inter-rater reliability as well as several interactions between raters and the other facets involved (that is examinees, rating criteria and rating methods). Results showed that raters were fairly consistent in their overall ratings. This finding has the great implications for controlling and assuring the quality of the rater-mediated assessment system.

  19. Reproducibility of scoring emphysema by HRCT

    International Nuclear Information System (INIS)

    Purpose: We evaluated the reproducibility of three visual scoring methods of emphysema and compared these methods with pulmonary function tests (VC, DLCO, FEV1 and FEV%) among farmer's lung patients and farmers. Material and Methods: Three radiologists examined high-resolution CT images of farmer's lung patients and their matched controls (n=70) for chronic interstitial lung diseases. Intraobserver reproducibility and interobserver variability were assessed for three methods: severity, Sanders' (extent) and Sakai. Pulmonary function tests as spirometry and diffusing capacity were measured. Results: Intraobserver -values for all three methods were good (0.51-0.74). Interobserver varied from 0.35 to 0.72. The Sanders' and the severity methods correlated strongly with pulmonary function tests, especially DLCO and FEV1. Conclusion: The Sanders' method proved to be reliable in evaluating emphysema, in terms of good consistency of interpretation and good correlation with pulmonary function tests

  20. Critical Care Nurses Inadequately Assess SAPS II Scores of Very Ill Patients in Real Life

    OpenAIRE

    Paolo Merlani; Marco Previsdomini; Andreas Perren; Ilaria Perren

    2012-01-01

    Background. Reliable ICU severity scores have been achieved by various healthcare workers but nothing is known regarding the accuracy in real life of severity scores registered by untrained nurses. Methods. In this retrospective multicentre audit, three reviewers independently reassessed 120 SAPS II scores. Correlation and agreement of the sum-scores/variables among reviewers and between nurses and the reviewers' gold standard were assessed globally and for tertiles. Bland and Altman (gold st...

  1. Stability and Change in the Cognitive and Adaptive Behaviour Scores of Preschoolers with Autism Spectrum Disorder.

    Science.gov (United States)

    Flanagan, Helen E; Smith, Isabel M; Vaillancourt, Tracy; Duku, Eric; Szatmari, Peter; Bryson, Susan; Fombonne, Eric; Mirenda, Pat; Roberts, Wendy; Volden, Joanne; Waddell, Charlotte; Zwaigenbaum, Lonnie; Bennett, Teresa; Elsabbagh, Mayada; Georgiades, Stelios

    2015-09-01

    We examined the stability of cognitive and adaptive behaviour standard scores in children with autism spectrum disorder (ASD) between diagnosis and school entry approximately age 6. IQ increased 18 points in 2-year-olds, 12 points in 3-year-olds, and 9 points in 4-year-olds (N = 281). Adaptive behaviour scores increased 4 points across age groups (N = 289). At school entry, 24 % of children met criteria for intellectual disability (cognitive and adaptive behaviour scores <70). No children with both scores ?70 at diagnosis later met criteria for intellectual disability. Outcomes were more variable for children with initial delays in both areas (in 57 %, both scores remained <70). Findings are relevant to clinical decision-making, including specification of intellectual disability in young children with ASD. PMID:25835210

  2. Dual Criteria Decisions

    DEFF Research Database (Denmark)

    Andersen, Steffen; Harrison, Glenn W.

    2014-01-01

    The most popular models of decision making use a single criterion to evaluate projects or lotteries. However, decision makers may actually consider multiple criteria when evaluating projects. We consider a dual criteria model from psychology. This model integrates the familiar tradeoffs between risk and utility that economists traditionally assume, allowance for rank-dependent decision weights, and consideration of income thresholds. We examine the issues involved in full maximum likelihood estimation of the model using observed choice data. We propose a general method for integrating the multiple criteria, using the logic of mixture models, which we believe is attractive from a decision-theoretic and statistical perspective. The model is applied to observed choices from a major natural experiment involving intrinsically dynamic choices over highly skewed outcomes. The evidence points to the clear role that income thresholds play in such decision making, but does not rule out a role for tradeoffs between riskand utility or probability weighting.

  3. Summarized water quality criteria

    International Nuclear Information System (INIS)

    The available world literature from 27 sources on existing water quality criteria are summarized for the 15 main uses of water. The minimum, median and maximum specified values for 96 different determinands are included. Under each water use the criteria are grouped according to the functional significance of the determinands e.g. aesthetic/physical effects, high toxic potential, low toxic potential etc. A synopsis is included summarizing salient facts for each determinand such as the conditions under which it is toxic and its relationship to other determinands. The significance of the criteria is briefly discussed and the importance of considering functional interactions between determinands emphasized in evaluating the potential for toxic or beneficial effects. From the source literature it appears that the toxic potential, in addition to being determined by concentration, is also affected by the origin of the substance concerned, i.e. whether from natural sources or from anthropogenic pollution

  4. Dual Criteria Decisions

    DEFF Research Database (Denmark)

    Andersen, Steffen; Harrison, Glenn W.; Lau, Morten Igel; Rutström, Elisabet E.

    2014-01-01

    The most popular models of decision making use a single criterion to evaluate projects or lotteries. However, decision makers may actually consider multiple criteria when evaluating projects. We consider a dual criteria model from psychology. This model integrates the familiar tradeoffs between...... risk and utility that economists traditionally assume, allowance for rank-dependent decision weights, and consideration of income thresholds. We examine the issues involved in full maximum likelihood estimation of the model using observed choice data. We propose a general method for integrating the...... multiple criteria, using the logic of mixture models, which we believe is attractive from a decision-theoretic and statistical perspective. The model is applied to observed choices from a major natural experiment involving intrinsically dynamic choices over highly skewed outcomes. The evidence points to...

  5. Flame temperature criteria tests

    International Nuclear Information System (INIS)

    Since the Lewis-Karlovitz flame temperature criteria had been based on data obtained from hydrogen flammability tests using hydrogen-air mixtures at room temperature and atmospheric pressure, a test program was conducted at Fenwal Incorporated to evaluate its applicability to a post-accident containment atmosphere at elevated temperature and pressure. Another objective of this test program was to obtain laminar burning velocities under post-accident containment atmospheric conditions. These velocities are needed for estimating the hydrogen burn time in containments. This paper presents the results obtained from this test program, which are then used to validate the Lewis-Karlovitz flame temperature criteria

  6. RANKING CHEMISTRY JOURNALS USING THE HIRSCH INDEX AND ARTICLE INFLUENCE SCORE

    OpenAIRE

    SILVIU JIPA; LAURA MONICA GORGHIU; CRINELA DUMITRESCU; CALIN OROS

    2012-01-01

    This study presents the Hirsch-index, impact factor and article influence score for the ranking of Chemistry journals. The study concludes that the Hirsch-index exhibits a good correlation with the influence score. A correlation of 60 Chemistry journals is analyzed.

  7. Association between value-based purchasing score and hospital characteristics

    Science.gov (United States)

    2012-01-01

    Background Medicare hospital Value-based purchasing (VBP) program that links Medicare payments to quality of care will become effective from 2013. It is unclear whether specific hospital characteristics are associated with a hospital’s VBP score, and consequently incentive payments. The objective of the study was to assess the association of hospital characteristics with (i) the mean VBP score, and (ii) specific percentiles of the VBP score distribution. The secondary objective was to quantify the associations of hospital characteristics with the VBP score components: clinical process of care (CPC) score and patient satisfaction score. Methods Observational analysis that used data from three sources: Medicare Hospital Compare Database, American Hospital Association 2010 Annual Survey and Medicare Impact File. The final study sample included 2,491 U.S. acute care hospitals eligible for the VBP program. The association of hospital characteristics with the mean VBP score and specific VBP score percentiles were assessed by ordinary least square (OLS) regression and quantile regression (QR), respectively. Results VBP score had substantial variations, with mean score of 30 and 60 in the first and fourth quartiles of the VBP score distribution. For-profit status (vs. non-profit), smaller bed size (vs. 100–199 beds), East South Central region (vs. New England region) and the report of specific CPC measures (discharge instructions, timely provision of antibiotics and beta blockers, and serum glucose controls in cardiac surgery patients) were positively associated with mean VBP scores (p<0.01 in all). Total number of CPC measures reported, bed size of 400–499 (vs. 100–199 beds), a few geographic regions (Mid-Atlantic, West North Central, Mountain and Pacific) compared to the New England region were negatively associated with mean VBP score (p<0.01 in all). Disproportionate share index, proportion of Medicare and Medicaid days to total inpatient days had significant (p<0.01) but small effects. QR results indicate evidence of differential effects of some of the hospital characteristics across low-, medium- and high-quality providers. Conclusions Although hospitals serving the poor and the elderly are more likely to score lower under the VBP program, the correlation appears small. Profit status, geographic regions, number and type of CPC measures reported explain the most variation among scores. PMID:23244445

  8. Validation of the Rheumatoid and Arthritis Outcome Score (RAOS for the lower extremity

    Directory of Open Access Journals (Sweden)

    Petersson Ingemar F

    2003-10-01

    Full Text Available Abstract Background Patients with inflammatory joint diseases tend due to new treatments to be more physically active; something not taken into account by currently used outcome measures. The Rheumatoid and Arthritis Outcome Score (RAOS is an adaptation of the Knee injury and Osteoarthritis Outcome Score (KOOS and evaluates functional limitations of importance to physically active people with inflammatory joint diseases and problems from the lower extremities. The aim of the study was to test the RAOS for validity, reliability and responsiveness. Methods 119 in-patients with inflammatory joint disease (51% RA admitted to multidisciplinary care, mean age 56 (±13, 73% women, mean disease duration 18 (±14 yr were consecutively enrolled. They all received the RAOS, the SF-36, the HAQ and four subscales of the AIMS2 twice during their stay for test of validity and responsiveness. Test-retest reliability of the RAOS questionnaire was calculated on 52 patients using the first or second administration and an additional mailed questionnaire. Results The RAOS met set criteria of reliability and validity. The random intraclass correlation coefficient (ICC 2,1 for the five subscales ranged from 0.76 to 0.92, indicating that individual comparisons were possible except for the subscale Sport and Recreation Function. Inter-item correlation measured by Cronbach's alpha ranged from 0.78 to 0.95. When measuring construct validity the highest correlations occurred between subscales intended to measure similar constructs. Change over time (24 (± 7 days due to multidisciplinary care was significant for all subscales (p Conclusion It is possible to adapt already existing outcome measures to assess other groups with musculoskeletal difficulties in the lower extremity. The RAOS is a reliable, valid and responsive outcome instrument for assessment of multidisciplinary care. To fully validate the RAOS further studies are needed in other populations.

  9. Greek stroke score, Siriraj score and allen score in clinical diagnosis of intracerebral hemorrhage and infarct: Validation and comparison study

    OpenAIRE

    Soman Aamod; Joshi Shashank; Tarvade Sanjay; Jayaram S

    2004-01-01

    AIM: To compare Greek stroke score with available previous two stroke scores for the diagnosis of cerebral ischemia and hemorrhage in acute stroke patients, and validate the Greek stroke score. SETTING: A tertiary hospital in India. MATERIALS AND METHODS: In a prospective study acute stroke patients were evaluated with Greek stroke score, Allen score and Siriraj stroke score. Comparability (Kappa Statistics) and validity (sensitivity, specificity, negative predictive value and positive predic...

  10. Explicit criteria for prioritization of cataract surgery

    Directory of Open Access Journals (Sweden)

    Escobar Antonio

    2006-03-01

    Full Text Available Abstract Background Consensus techniques have been used previously to create explicit criteria to prioritize cataract extraction; however, the appropriateness of the intervention was not included explicitly in previous studies. We developed a prioritization tool for cataract extraction according to the RAND method. Methods Criteria were developed using a modified Delphi panel judgment process. A panel of 11 ophthalmologists was assembled. Ratings were analyzed regarding the level of agreement among panelists. We studied the effect of all variables on the final panel score using general linear and logistic regression models. Priority scoring systems were developed by means of optimal scaling and general linear models. The explicit criteria developed were summarized by means of regression tree analysis. Results Eight variables were considered to create the indications. Of the 310 indications that the panel evaluated, 22.6% were considered high priority, 52.3% intermediate priority, and 25.2% low priority. Agreement was reached for 31.9% of the indications and disagreement for 0.3%. Logistic regression and general linear models showed that the preoperative visual acuity of the cataractous eye, visual function, and anticipated visual acuity postoperatively were the most influential variables. Alternative and simple scoring systems were obtained by optimal scaling and general linear models where the previous variables were also the most important. The decision tree also shows the importance of the previous variables and the appropriateness of the intervention. Conclusion Our results showed acceptable validity as an evaluation and management tool for prioritizing cataract extraction. It also provides easy algorithms for use in clinical practice.

  11. The value of CT score in predicting surgical methods and difficulty of hepatic cystic echinococcosis

    International Nuclear Information System (INIS)

    Objective: To evaluate the value of MSCT scores on surgery method selection and its difficulty estimation for hepatic cystic echinococcosis. Methods: Based on the CT features of hepatic cystic echinococcosis (HCE), an integral system including 7 items was established. Images of preoperative CT examination performed on 71 cases of hepatic cystic echinococcosis were retrospectively analyzed by the integral system and compared with actual surgical. Total 93 cystic lesions were divided into 3 groups based on CT scores: Group A suitable for total cystectomy (0 to 5 score), Group B suitable for subtotal cystectomy (6 to 10 score), and Group C suitable forendocystectomy ( ? 11 scores, or 4 score in one item), Spearman rank correlation was used to analyze the relationship between WHO classification of cystic echinococcosis and actual surgery methods, the relationship between operation mode forecasted by CT scores and actual surgery methods, the relationship between vessel scores of cyst and actual surgery methods, and that between biliary score of cyst and actual surgery methods. Fisher exact test and Chi-square test were used to evaluate the incidence of residual cavity in patients with different biliary scores. Results: Thirty nine cysts got 0 to 5 scores, 45 cysts got 6 to 10 scores and 9 cysts got more than 10 scores. Total cystectomy was performed on 30 cysts, subtotal cystectomy on 40 cysts and performed endocystectomy on 23 cysts, actually. Actual operation methods were correlated with that predicated by CT scores (r=0.741, P<0.01), and with vessels score and biliary score (r=0.587, 0.327 respectively, P<0.01). The higher the biliary score, the higher the incidence of postoperative biliary tract complications. Conclusions: Preoperative CT scoring was an easy and objective way to accurately predict the surgery methods and its difficulty for hepatic cystic echinococcosis. (authors)

  12. Residual radioactivity criteria

    International Nuclear Information System (INIS)

    This paper provides an overview of current and future decommissioning standards applicable in the United States. The standards promulgated by both the US Department of Energy (DOE) and the US Nuclear Regulatory Commission (NRC), as well as standards proposed by the American National Standards Institute, are presented. A summary is presented of the recent NRC actions to produce revised residual radioactivity criteria

  13. A new scoring system for predicting survival in patients with non-small cell lung cancer

    International Nuclear Information System (INIS)

    This analysis was performed to create a scoring system to estimate the survival of patients with non-small cell lung cancer (NSCLC). Data from 1274 NSCLC patients were analyzed to create and validate a scoring system. Univariate (UV) and multivariate (MV) Cox models were used to evaluate the prognostic importance of each baseline factor. Prognostic factors that were significant on both UV and MV analyses were used to develop the score. These included quality of life, age, performance status, primary tumor diameter, nodal status, distant metastases, and smoking cessation. The score for each factor was determined by dividing the 5-year survival rate (%) by 10 and summing these scores to form a total score. MV models and the score were validated using bootstrapping with 1000 iterations from the original samples. The score for each prognostic factor ranged from 1 to 7 points with higher scores reflective of better survival. Total scores (sum of the scores from each independent prognostic factor) of 32–37 correlated with a 5-year survival of 8.3% (95% CI = 0–17.1%), 38–43 correlated with a 5-year survival of 20% (95% CI = 13–27%), 44–47 correlated with a 5-year survival of 48.3% (95% CI = 41.5–55.2%), 48–49 correlated to a 5-year survival of 72.1% (95% CI = 65.6–78.6%), and 50–52 correlated to a 5-year survival of 84.7% (95% CI = 79.6–89.8%). The bootstrap method confirmed the reliability of the score. Prognostic factors significantly associated with survival on both UV and MV analyses were used to construct a valid scoring system that can be used to predict survival of NSCLC patients. Optimally, this score could be used when counseling patients, and designing future trials

  14. A new scoring system for predicting survival in patients with non-small cell lung cancer.

    Science.gov (United States)

    Schild, Steven E; Tan, Angelina D; Wampfler, Jason A; Ross, Helen J; Yang, Ping; Sloan, Jeff A

    2015-09-01

    This analysis was performed to create a scoring system to estimate the survival of patients with non-small cell lung cancer (NSCLC). Data from 1274 NSCLC patients were analyzed to create and validate a scoring system. Univariate (UV) and multivariate (MV) Cox models were used to evaluate the prognostic importance of each baseline factor. Prognostic factors that were significant on both UV and MV analyses were used to develop the score. These included quality of life, age, performance status, primary tumor diameter, nodal status, distant metastases, and smoking cessation. The score for each factor was determined by dividing the 5-year survival rate (%) by 10 and summing these scores to form a total score. MV models and the score were validated using bootstrapping with 1000 iterations from the original samples. The score for each prognostic factor ranged from 1 to 7 points with higher scores reflective of better survival. Total scores (sum of the scores from each independent prognostic factor) of 32-37 correlated with a 5-year survival of 8.3% (95% CI = 0-17.1%), 38-43 correlated with a 5-year survival of 20% (95% CI = 13-27%), 44-47 correlated with a 5-year survival of 48.3% (95% CI = 41.5-55.2%), 48-49 correlated to a 5-year survival of 72.1% (95% CI = 65.6-78.6%), and 50-52 correlated to a 5-year survival of 84.7% (95% CI = 79.6-89.8%). The bootstrap method confirmed the reliability of the score. Prognostic factors significantly associated with survival on both UV and MV analyses were used to construct a valid scoring system that can be used to predict survival of NSCLC patients. Optimally, this score could be used when counseling patients, and designing future trials. PMID:26108458

  15. Translatability scoring in drug development: eight case studies

    Directory of Open Access Journals (Sweden)

    Wendler Alexandra

    2012-03-01

    Full Text Available Abstract Translational medicine describes the transfer of basic in vitro and in vivo data into human applications. In the light of low rates of market approvals for new medical entities, better strategies to predict the risk of drug development should be used to increase output and reduce costs. Recently, a scoring system to assess the translatability of early drug projects has been proposed. Here eight drugs from different therapeutic areas have been subjected to a retrospective test-run in this system fictively located at the phase II-III transition. The scores gained here underline the importance of biomarker quality which is pivotal to decrease the risk of the project in all cases. This is particularly evident for gefitinib. The EGFR mutation status is a breakthrough biomarker to predict therapeutic success which made this compound clinically acceptable, and this is plausibly reflected by a considerable increase of the translatability score. For psychiatric and Alzheimer's drugs, and for a CETP-inhibitor, the lack of suitable biomarkers and animal models is reflected by a low translatability score, well correlating with the excessive translational risk in these areas. These case studies document the apparent utility of the scoring system, at least under retrospective conditions, as the scores correlate with the outcomes at the level of market approval. Prospective validation is still missing, but these case studies are encouraging.

  16. Criteria for the diagnosis of corticobasal degeneration

    Science.gov (United States)

    Armstrong, Melissa J.; Lang, Anthony E.; Bak, Thomas H.; Bhatia, Kailash P.; Borroni, Barbara; Boxer, Adam L.; Dickson, Dennis W.; Grossman, Murray; Hallett, Mark; Josephs, Keith A.; Kertesz, Andrew; Lee, Suzee E.; Miller, Bruce L.; Reich, Stephen G.; Riley, David E.; Tolosa, Eduardo; Tröster, Alexander I.; Vidailhet, Marie; Weiner, William J.

    2013-01-01

    Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations. An international consortium of behavioral neurology, neuropsychology, and movement disorders specialists developed new criteria based on consensus and a systematic literature review. Clinical diagnoses (early or late) were identified for 267 nonoverlapping pathologically confirmed CBD cases from published reports and brain banks. Combined with consensus, 4 CBD phenotypes emerged: corticobasal syndrome (CBS), frontal behavioral-spatial syndrome (FBS), nonfluent/agrammatic variant of primary progressive aphasia (naPPA), and progressive supranuclear palsy syndrome (PSPS). Clinical features of CBD cases were extracted from descriptions of 209 brain bank and published patients, providing a comprehensive description of CBD and correcting common misconceptions. Clinical CBD phenotypes and features were combined to create 2 sets of criteria: more specific clinical research criteria for probable CBD and broader criteria for possible CBD that are more inclusive but have a higher chance to detect other tau-based pathologies. Probable CBD criteria require insidious onset and gradual progression for at least 1 year, age at onset ?50 years, no similar family history or known tau mutations, and a clinical phenotype of probable CBS or either FBS or naPPA with at least 1 CBS feature. The possible CBD category uses similar criteria but has no restrictions on age or family history, allows tau mutations, permits less rigorous phenotype fulfillment, and includes a PSPS phenotype. Future validation and refinement of the proposed criteria are needed. PMID:23359374

  17. LSAT Scores of Economics Majors.

    Science.gov (United States)

    Nieswiadomy, Michael

    1998-01-01

    Argues that economics education provides many benefits to students, including preparation for law school. Examines the ranking of economics majors on the Law School Admission Test (LSAT). Finds that among the 14 majors having more than 2,000 students take the LSAT, economics students received the highest average score. (DSK)

  18. About Unitary Rating Score Constructing

    CERN Document Server

    Victor, K

    2004-01-01

    It is offered to pool test points of different subjects and different aspects of the same subject together in order to get the unitary rating score, by the way of nonlinear transformation of indicator points in accordance with Zipf's distribution. It is proposed to use the well-studied distribution of Intellectuality Quotient IQ as the reference distribution for latent variable "progress in studies".

  19. A novel cleansing score system for capsule endoscopy

    Directory of Open Access Journals (Sweden)

    Sung Chul Park, Bora Keum, Jong Jin Hyun, Yeon Seok Seo, Yong Sik Kim, Yoon Tae Jeen, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu

    2010-02-01

    Full Text Available AIM: To suggest a new cleansing score system for small bowel preparation and to evaluate its clinical efficacy.METHODS: Twenty capsule endoscopy cases were reviewed and small bowel preparation was assessed with the new scoring system. For the assessment, two visual parameters were used: proportion of visualized mucosa and degree of obscuration. Representative frames from small bowel images were serially selected and scored at 5-min intervals. Intraclass correlation coefficient (ICC was obtained to assess the reliability of the new scoring system. For efficacy evaluation and validation, scores of our new scoring system were compared with another previously reported cleansing grading system.RESULTS: Concordance with the previous system, inter-observer agreement, and intra-patient agreement were excellent with ICC values of 0.82, 0.80, and 0.76, respectively. The intra-observer agreements at four-week intervals were also excellent. The cut-off value of adequate image quality was found to be 2.25.CONCLUSION: Our new scoring system is simple, efficient, and can be considered to be applicable in clinical practice and research.

  20. Association between eating behavior scores and obesity in Chilean children

    Directory of Open Access Journals (Sweden)

    Amador Paola

    2011-10-01

    Full Text Available Abstract Background Inadequate eating behavior and physical inactivity contribute to the current epidemic of childhood obesity. The aim of this study was to assess the association between eating behavior scores and childhood obesity in Chilean children. Design and methods We recruited 126 obese, 44 overweight and 124 normal-weight Chilean children (6-12 years-old; both genders according to the International Obesity Task Force (IOTF criteria. Eating behavior scores were calculated using the Child Eating Behavior Questionnaire (CEBQ. Factorial analysis in the culturally-adapted questionnaire for Chilean population was used to confirm the original eight-factor structure of CEBQ. The Cronbach's alpha statistic (>0.7 in most subscales was used to assess internal consistency. Non-parametric methods were used to assess case-control associations. Results Eating behavior scores were strongly associated with childhood obesity in Chilean children. Childhood obesity was directly associated with high scores in the subscales "enjoyment of food" (P Conclusion Our study shows a strong and graded association between specific eating behavior scores and childhood obesity in Chile.

  1. Correlation between HRCT and pulmonary functional tests in cystic fibrosis

    International Nuclear Information System (INIS)

    Purpose. To compare the HRCT score by Oikonottlou and air trapping in expiratory scans with pulmonary functional tests and evaluate which radiological criteria are more useful to predict clinical impairment. Materials and methods. From January to September 2003, pulmonary HRCT study was performed in 37 patients (23 males), aged between 7 and 41 years, with cystic fibrosis. In the same day of CT examination they also received a complete functional evaluation. HRCT studies were evaluated by three radiologists blinded to the clinical data and were correlated with the lung function tests. Results. We obtained a high correlation (p=0.01) for two of the HRCT signs: extent of mucus plugging and mosaic perfusion pattern and all function tests. Discussion. Previous studies have demonstrated good correlation between lung function tests, in particular with FEV1 and HRCT signs. Our study differed from previous ones in that we analysed the correlation between lung function tests and with both single and combined CT criteria. Conclusion. Our results suggest that a simplified HRCT store could be useful to evaluate patients with cystic fibrosis

  2. Clinical performance of two visual scoring systems in detecting and assessing activity status of occlusal caries in primary teeth

    DEFF Research Database (Denmark)

    Braga, M M; Ekstrand, K R; Martignon, S; Imparato, J C P; Ricketts, D N J; Pedersen, Lia Mendes

    2010-01-01

    This study aimed to compare the clinical performance of two sets of visual scoring criteria for detecting caries severity and assessing caries activity status in occlusal surfaces. Two visual scoring systems--the Nyvad criteria (NY) and the ICDAS-II including an adjunct system for lesion activity assessment (ICDAS-LAA)--were compared using 763 primary molars of 139 children aged 3-12 years. The examinations were performed by 2 calibrated examiners. A subsample (n = 50) was collected after extrac...

  3. Quantifying radioxerostomia: salivary flow rate, examiner's score, and quality of life questionnaire

    Energy Technology Data Exchange (ETDEWEB)

    Al-Nawas, B.; Al-Nawas, K.; Kunkel, M.; Groetz, K.A. [Dept. of Oral and Maxillofacial Surgery, Hospital of the Johannes Gutenberg Univ., Mainz (Germany)

    2006-06-15

    Background and purpose: salivary flow rates alone are not sufficient to quantify all aspects of radioxerostomia. This is a problem in studies aiming to reduce radioxerostomia. The aim of this study was to evaluate the association between objectively measured salivary flow rate and subjective xerostomia ratings by the physician (RTOG scale) or the patients (quality of life [QoL] questionnaire). Patients and methods: in a case-control study patients who underwent recall for oral cancer were screened. Inclusion criteria for this diagnostic, noninterventional study were: history of oral carcinoma, surgical and radiation therapy, time interval from start of radiation therapy > 90 days, salivary glands within the radiation field. The control group consisted of patients, who had not received radiotherapy. RTOG salivary gland score, quality of life (EORTC QLQ-C30 and H and N35), and sialometry were recorded. Results: patients with RTOG score 0 had mean salivary flow rates of 0.3 ml/min, those with RTOG 1 0.12 ml/min, RTOG 2 0.02 ml/min, and RTOG 3 < 0.01 ml/min. RTOG score 4 (total fibrosis) did not occur. Based on salivary flow rates, all patients were grouped into xerostomia < 0.2 ml/min (30 patients) and nonxerostomia (twelve patients). QoL results revealed significant differences between patients with xerostomia and nonxerostomia for physical function, dyspnea, swallowing, social eating, dry mouth, nutritional support, and a tendency to higher values for appetite loss. Conclusion: the correlation between ''subjective'' QoL parameters and salivary flow was confirmed. The different subjective aspects of radioxerostomia seem to be better differentiated by the EORTC QoL questionnaire. (orig.)

  4. Do medical students’ scores using different assessment instruments predict their scores in clinical reasoning using a computer-based simulation?

    Directory of Open Access Journals (Sweden)

    Fida M

    2015-02-01

    Full Text Available Mariam Fida,1 Salah Eldin Kassab2 1Department of Molecular Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain; 2Department of Medical Education, Faculty of Medicine, Suez Canal University, Ismailia, Egypt Purpose: The development of clinical problem-solving skills evolves over time and requires structured training and background knowledge. Computer-based case simulations (CCS have been used for teaching and assessment of clinical reasoning skills. However, previous studies examining the psychometric properties of CCS as an assessment tool have been controversial. Furthermore, studies reporting the integration of CCS into problem-based medical curricula have been limited. Methods: This study examined the psychometric properties of using CCS software (DxR Clinician for assessment of medical students (n=130 studying in a problem-based, integrated multisystem module (Unit IX during the academic year 2011–2012. Internal consistency reliability of CCS scores was calculated using Cronbach's alpha statistics. The relationships between students' scores in CCS components (clinical reasoning, diagnostic performance, and patient management and their scores in other examination tools at the end of the unit including multiple-choice questions, short-answer questions, objective structured clinical examination (OSCE, and real patient encounters were analyzed using stepwise hierarchical linear regression. Results: Internal consistency reliability of CCS scores was high (?=0.862. Inter-item correlations between students' scores in different CCS components and their scores in CCS and other test items were statistically significant. Regression analysis indicated that OSCE scores predicted 32.7% and 35.1% of the variance in clinical reasoning and patient management scores, respectively (P<0.01. Multiple-choice question scores, however, predicted only 15.4% of the variance in diagnostic performance scores (P<0.01, while students’ scores in real patient encounters did not predict any of the CCS scores. Conclusion: Students’ scores in OSCE are the most important predictors of their scores in clinical reasoning and patient management using CCS. However, real patient encounter assessment does not appear to test a construct similar to what is tested in CCS. Keywords: medical education, computer-based simulations, virtual patients, student assessment, PBL, Bahrain

  5. Human Systems Design Criteria

    DEFF Research Database (Denmark)

    Rasmussen, Jens

    1982-01-01

    This paper deals with the problem of designing more humanised computer systems. This problem can be formally described as the need for defining human design criteria, which — if used in the design process - will secure that the systems designed get the relevant qualities. That is not only the...... necessary functional qualities but also the needed human qualities. The author's main argument is, that the design process should be a dialectical synthesis of the two points of view: Man as a System Component, and System as Man's Environment. Based on a man's presentation of the state of the art a set of...... design criteria is suggested and their relevance discussed. The point is to focus on the operator rather than on the computer. The crucial question is not to program the computer to work on its own conditions, but to “program” the operator to function on human conditions....

  6. Interobserver agreement for diagnostic MRI criteria in suspected multiple sclerosis

    International Nuclear Information System (INIS)

    MRI is the paraclinical test most widely used to support the diagnosis of multiple sclerosis (MS). We evaluated interobserver agreement in applying diagnostic criteria to MRI obtained at first presentation. Five experienced observers scored 25 sets of images consisting of unenhanced T2- and gadolinium-enhanced T1-weighted images (approximately half the sets were normal). We scored frontal, parietal, temporal, occipital, infratentorial and basal ganglia lesions and the total number of lesions on T2-weighted images; periventricular, callosal, juxtacortical and ovoid lesions and those > 5 mm in maximum diameter; contrast-enhancing and hypointense lesions. Based on a combination of imaging findings patients were classified as compatible or not compatible with MS according to composite criteria. Observer concordance was characterised by weighted kappa values (?) and mean average difference to the median (MADM) scores. Using the raw scores, there was poor agreement for the total number of lesions on T2-weighted images, and for occipital, oval, juxtacortical and hypointense lesions. Moderate agreement was found for frontal, callosal, basal ganglia and large lesions on T2 weighting. Good agreement was attained for parietal, temporal, infratentorial and periventricular lesions. After dichotomisation according to accepted cut-off values, most criteria performed better, especially the number of lesions on T2-weighted images (P < 0.05). Good agreement was found for the criteria of Paty and Fazekas and moderate agreement for those of Barkhof. While experienced observers may not agree on the total number of lesions, they show quite good agreement for commonly used cut-off points and elements in the composite criteria. This validates the use of MRI in the diagnosis of MS, and the use of dichotomised and composite criteria. (orig.)

  7. Score Function of Distribution and Heavy-tails.

    Czech Academy of Sciences Publication Activity Database

    Fabián, Zden?k

    ISI, 2014. s. 49-49. [COMPSTAT 2014. International Conference on Computational Statistics /21./. 19.08.2014-22.08.2014, Geneva] Institutional support: RVO:67985807 Keywords : score function * point estimation * correlation * heavy-tailed distributions Subject RIV: BB - Applied Statistics , Operational Research

  8. Use of e-rater[R] in Scoring of the TOEFL iBT[R] Writing Test. Research Report. ETS RR-11-25

    Science.gov (United States)

    Haberman, Shelby J.

    2011-01-01

    Alternative approaches are discussed for use of e-rater[R] to score the TOEFL iBT[R] Writing test. These approaches involve alternate criteria. In the 1st approach, the predicted variable is the expected rater score of the examinee's 2 essays. In the 2nd approach, the predicted variable is the expected rater score of 2 essay responses by the…

  9. Acceptance criteria for determining armed response force size at nuclear power plants

    International Nuclear Information System (INIS)

    This guidance document contains acceptance criteria to be used in the NRC license review process. It consists of a scored worksheet and guidelines for interpreting the worksheet score that can be used in determining the adequacy of the armed response force size at a nuclear power reactor facility

  10. Team Performance with Test Scores

    OpenAIRE

    Kleinberg, Jon; Raghu, Maithra

    2015-01-01

    Team performance is a ubiquitous area of inquiry in the social sciences, and it motivates the problem of team selection -- choosing the members of a team for maximum performance. Influential work of Hong and Page has argued that testing individuals in isolation and then assembling the highest-scoring ones into a team is not an effective method for team selection. For a broad class of performance measures, based on the expected maximum of random variables representing individual candidates, we...

  11. Systemic Risk Score: A Suggestion

    OpenAIRE

    Hurlin, Christophe; Pérignon, Christophe

    2013-01-01

    We identify a potential bias in the methodology disclosed in July 2013 by the Basel Committee on Banking Supervision (BCBS) for identifying systemically important financial banks. Contrary to the original objective, the relative importance of the five categories of risk importance (size, cross-jurisdictional activity, interconnectedness, substitutability/financial institution infrastructure, and complexity) may not be equal and the resulting systemic risk scores are mechanically dominated by ...

  12. Bootstrapping Manski's Maximum Score Estimator

    CERN Document Server

    Seijo, Emilio

    2011-01-01

    In this paper we study the applicability of the bootstrap to do inference on Manski's maximum score estimator under the full generality of the model. We propose three new, model-based bootstrap procedures for this problem and show their consistency. Simulation experiments are carried out to evaluate their performance and to compare them with subsampling methods. Additionally, we prove a uniform convergence theorem for triangular arrays of random variables coming from binary choice models, which may be of independent interest.

  13. Admissions Criteria and Diversity in Graduate School

    CERN Document Server

    Miller, Casey W

    2013-01-01

    In this work, I point out the negative implications for diversity in graduate school resulting from the use of cutoff scores on the GRE in the admissions process. In light of the data presented, as well as a swelling body of evidence suggesting no long term correlation with research success, I pose several challenges to the community related to the continued use of the GRE.

  14. Representación del "score" Gleason en la biopsia prostática del "score" Gleason definitivo de la prostatectomía radical / Evidence of the radical prostatectomy Gleason score in the biopsy Gleason score

    Scientific Electronic Library Online (English)

    F., Algaba Arrea; A., Chivite de León; J.Mª, Santaularia Segura; A., Oliver Samper.

    2004-01-01

    Full Text Available INTRODUCCIÓN: El grado de diferenciación del adenocarcinoma de próstata por el método de Gleason ("score" Gleason) (sG) es un factor pronóstico post-prostatectomía radical, por lo que su representatividad en la biopsia es de sumo interés. PACIENTES Y MÉTODOS: Doscientos quince pacientes con determin [...] ación del sG en la biopsia y la pieza de prostatectomía, determinado a ciegas por el mismo equipo de tres patólogos. RESULTADOS: Coincidencia exacta en un 49,7%, infravaloración en la biopsia en un 38,6% y sobrevaloración en la biopsia en un 11,6%. El análisis por sG revela: ausencia de casos con sG 2 en la biopsia. No-reproducibilidad en la pieza de los sG 3 y 4 de las biopsias. Coincidencia de los sG 5, 6, 7, 8 y 9 en biopsia del 25%, 45%, 72,7%, 36,8% y 60%, respectivamente (? global 0,32 ± 0,047, p Abstract in english INTRODUCTION: The Gleason score (Gs) for prostatic cancer has a good prognosis correlation after radical prostatectomy, for this reason its correlation with the Gs in the biopsy can be useful. PATIENTS AND METHODS: Two hundred fifteen patients with blind evaluation among three pathologists of their [...] Gs in biopsy and in the corresponding radical prostatectomy specimen are presented. RESULTS: The exact coincidence is present in 49.7% of cases, 38.6% of cases are under graded in the biopsy and 11.6% of them over graded in the biopsy. No cases of Gs 2 in the biopsy are found. Any case with Gs 3 and 4 in the biopsy are reproduced in the radical prostatectomy specimen. The exact coincidence for biopsy Gs 5, 6, 7, 8 and 9 are 25%, 45%, 72.7%, 36.6% and 60% respectively (? 0.32 ± 0.047, p

  15. Does Work Environment Affect Faculty Health Scores?

    OpenAIRE

    Rhonda C. Magel

    2013-01-01

    This study investigates the relationship between self-reported health scores with work environment and various components of a women faculty score at a Research 1 University in the Midwest USA. The study examines the differences between male and female faculty responses in the various components making up the women faculty score and also gender differences in self-reported health scores and work environment scores. Differences between STEM and Non-STEM faculty are examined. A significant...

  16. Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity

    Directory of Open Access Journals (Sweden)

    Cheyda Chams-Davatchi

    2013-04-01

    Full Text Available Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. However, there is no gold standard to measure the disease activity in clinical trials. In this study we aimed to introduce the pemphigus vulgaris activity score (PVAS measurement and to assess the convergent validity with the experts’ opinion of disease activity. In PVAS scoring, the distribution of pemphigus vulgaris antigen expression in different anatomical regions is taking in to account with special consideration of the healing process. PVAS is a 0-18 scale, based on the extent of mucocutaneous involvement, type of lesion and the presence of Nikolsky’s sign. The sum of the scores of total number of lesions, number of different anatomic regions involvement and Nikolsky’s sign is weighted by the type of lesion. In the present study, PVAS was assessed in 50 patients diagnosed with pemphigus vulgaris by one dermatologist. Independently, five blinded experts scored all the patients through physician’s global assessment (PGA. The convergent validity with experts’ opinion was assessed. The Spearman coefficient of correlation showed the acceptable value of 0.751 (95%CI: 0.534- 0.876. PVAS is a valid, objective and simple-to-use scoring measurement. It showed a good correlation with PGA of pemphigus disease activity in Iranian patients with pemphigus vulgaris

  17. 30-Day Mortality in Acute Pulmonary Embolism: Prognostic Value of Clinical Scores and Anamnestic Features

    OpenAIRE

    Bach, Andreas Gunter; Taute, Bettina-Maria; Baasai, Nansalmaa; Wienke, Andreas; Meyer, Hans Jonas; Schramm, Dominik; Surov, Alexey

    2016-01-01

    Purpose Identification of high-risk patients with pulmonary embolism is vital. The aim of the present study was to examine clinical scores, their single items, and anamnestic features in their ability to predict 30-day mortality. Materials and Methods A retrospective, single-center study from 06/2005 to 01/2010 was performed. Inclusion criteria were presence of pulmonary embolism, availability of patient records and 30-day follow-up. The following clinical scores were calculated: Acute Physio...

  18. A validation study of the New Zealand score for hip and knee surgery.

    OpenAIRE

    Toyé, F; Barlow, J.; WRIGHT, C; Lamb, SE

    2007-01-01

    UNLABELLED: In the absence of consensus over criteria for performing total knee arthroplasty, the variability of symptom burden, and limited resources, some ways to prioritize whether and when to treat would be useful. In the UK, some payers use the New Zealand score to determine access to an orthopaedic surgeon despite limited validation. We tested convergent validity of this score and ascertained its ability to discriminate between groups of patients with high or low disease burden as deter...

  19. Dismissal Criteria in Voice Therapy

    Science.gov (United States)

    Boone, Daniel R.

    1974-01-01

    Five criteria to systematize the results of voice remediation and provide the therapist with criteria for terminating therapy in cases of hyperfunctional voice disorders were developed and applied to 73 patients aged from early childhood through adulthood. (DB)

  20. National Recommended Water Quality Criteria

    Data.gov (United States)

    U.S. Environmental Protection Agency — The National Recommended Water Quality Criteria is a compilation of national recommended water quality criteria for the protection of aquatic life and human health...

  1. Web site Evaluation Criteria

    Directory of Open Access Journals (Sweden)

    Mojdgan binesh

    2008-07-01

    Full Text Available The ever-increasing evolution of the Internet and the growing number of the resources accessible through this medium, has turned the issue of resource evaluation of the internet-based information into a controversial and cogent issue. By nature, the internet milieu is uncontrollable. It concomitantly contains both verifiable and unverifiable information. Thus it behooves the internet users to develop resource evaluation and critical thinking skills in order to discern appropriate quality resources. Through review and comparison of the available checklists, the present paper endeavors to offer criteria for website evaluation

  2. Enhancing reuse of structured eligibility criteria and supporting their relaxation.

    Science.gov (United States)

    Milian, Krystyna; Hoekstra, Rinke; Bucur, Anca; Ten Teije, Annette; van Harmelen, Frank; Paulissen, John

    2015-08-01

    Patient recruitment is one of the most important barriers to successful completion of clinical trials and thus to obtaining evidence about new methods for prevention, diagnostics and treatment. The reason is that recruitment is effort consuming. It requires the identification of candidate patients for the trial (the population under study), and verifying for each patient whether the eligibility criteria are met. The work we describe in this paper aims to support the comparison of population under study in different trials, and the design of eligibility criteria for new trials. We do this by introducing structured eligibility criteria, that enhance reuse of criteria across trials. We developed a method that allows for automated structuring of criteria from text. Additionally, structured eligibility criteria allow us to propose suggestions for relaxation of criteria to remove potentially unnecessarily restrictive conditions. We thereby increase the recruitment potential and generalizability of a trial. Our method for automated structuring of criteria enables us to identify related conditions and to compare their restrictiveness. The comparison is based on the general meaning of criteria, comprised of commonly occurring contextual patterns, medical concepts and constraining values. These are automatically identified using our pattern detection algorithm, state of the art ontology annotators and semantic taggers. The comparison uses predefined relations between the patterns, concept equivalences defined in medical ontologies, and threshold values. The result is a library of structured eligibility criteria which can be browsed using fine grained queries. Furthermore, we developed visualizations for the library that enable intuitive navigation of relations between trials, criteria and concepts. These visualizations expose interesting co-occurrences and correlations, potentially enhancing meta-research. The method for criteria structuring processes only certain types of criteria, which results in low recall of the method (18%) but a high precision for the relations we identify between the criteria (94%). Analysis of the approach from the medical perspective revealed that the approach can be beneficial for supporting trial design, though more research is needed. PMID:26015310

  3. Sustainable Criteria for Environmental Technology

    OpenAIRE

    Kjellberg, Kristin

    2004-01-01

    The demand for sustainable criteria for environmental technology has over the past few years increaseddue to competition amongst companies in the business due to legal demands. Using criteria for environmentaltechnology is a way for companies to show buyers that their product is a long term investment. Byimplementing sustainable criteria for environmental technology, companies can be sure they are buying andusing the best available technology adjusted to their economy. Sustainable criteria fo...

  4. Proposta para estadiamento do câncer colorretal baseada em critérios morfofuncionais: correlação com níveis séricos do antígeno carcinoembrionário Proposal for colorectal cancer stages based on morphofunctional criteria: correlation with carcinoembryonic antigen levels

    Directory of Open Access Journals (Sweden)

    Denise Gonçalves Priolli

    2007-12-01

    Full Text Available A análise de características morfofuncionais pode ser útil na predição evolutiva do câncer colorretal, especialmente se relacionadas aos níveis séricos de antígeno carcinoembrionário. A pesquisa de instabilidades de cromossomos e genes e alterações da expressão tecidual de proteínas por eles codificadas, tornam atraente a possibilidade do emprego de fatores funcionais como variáveis potencialmente válidas na compreensão do prognóstico do carcinoma colorretal.¹ OBJETIVO: Propor estadiamento baseado nas características morfológicas e funcionais do carcinoma colorretal, valorizando o poder prognóstico do antígeno carcinoembrionário. MÉTODO: Acompanhou-se 35 pacientes em estágios diferentes da evolução do adenocarcinoma colorretal no período de 2001 a 2007. A medida sérica do antígeno carcinoembrionário foi executada pela técnica de quimioluminescência. Realizou-se estudo anatomopatológico para determinação do grau histológico e estádio TNM, e análise imunohistoquímica para determinação da polarização tecidual do antígeno carcinoembrionário. A classificação morfofuncional foi determinada pela combinação entre grau histológico e polarização do antígeno. O estadiamento morfofuncional baseou-se na associação entre classificação morfofuncional e estadiamento TNM, por pontuação atribuída a cada uma das classificações. As variáveis estudadas foram: CEA sérico, classificação morfofuncional, estadiamento TNM e morfofuncional. Os resultados foram analisados por análise variância, teste de correlação e análise de sobrevivência (Kaplan-Meier e Modelo de Regressão de Cox, adotando-se p>0,05% para rejeição da hipótese de nulidade. RESULTADOS: A curva de sobrevida no estadiamento morfofuncional apresentou resultados semelhantes aos encontrados no estadiamento TNM. Houve relação entre a nova proposta de estadiamento e o tempo de sobrevida do paciente. Observou-se relação entre o tempo de sobrevida, a classificação morfofuncional e o nível sérico de antígeno carcinoembrionário. CONCLUSÃO: O estadiamento morfofuncional é válido para a avaliação prognóstica dos pacientes com adenocarcinoma colorretal, e relaciona-se com os níveis séricos do CEA.The analysis of morphofunctions characteristics can be useful in the colorectal cancer evolution, especially if related to the serum carcinoembryonic antigen levels. The research of chromosomes and genes instability, as well as the alterations of tissue protein codified, makes attractive the possibility to use potentially valid functional factors as variables for the understanding of colorectal carcinoma prognosis. OBJECTIVE: To consider classes based on morphologic and functional colorectal carcinoma characteristics, valuing serum carcinoembryonic antigen levels prognostic power. METHOD: Third-five patients in different stages of colorectal carcinoma underwent operations from 2001 to 2007. Serum CEA levels, histological grade, tissue CEA cell polarization capacity were analyzed. Colorectal carcinoma was classified according to TNM stages. The morphofunctional classification was determined by the combination between histological grade and antigen polarization, morphofunctional stages have been based in association between morphofunctional classification and stages TNM, by punctuation attributed to each one classification. The results had been analyzed by variance analysis, correlation test and survival analysis (Kaplan-Meier and Cox Model Regression, adopting p<0.05. RESULTS: Morphofunctional stages survival curve resulted similar to the joined ones in stages TNM. It had relation between new classification proposed and patient survival time. They had observed relation among survival time, morphofunctional classification and serum carcinoembryonic antigen. CONCLUSION: Morphofunctional classification is valid for colorectal cancer patient's prognostic evaluation and is related with the serum CEA levels.

  5. EuroSCORE II e a importância de um modelo local, InsCor e o futuro SP-SCORE / EuroSCORE II and the importance of a local model, InsCor and the future SP-SCORE

    Scientific Electronic Library Online (English)

    Luiz Augusto Ferreira, Lisboa; Omar Asdrubal Vilca, Mejia; Luiz Felipe Pinho, Moreira; Luís Alberto Oliveira, Dallan; Pablo Maria Alberto, Pomerantzeff; Luís Roberto Palma, Dallan; Maria Raquel B., Massoti; Fabio B., Jatene.

    2014-03-01

    Full Text Available Introdução: O modelo mais utilizado para predição de mortalidade em cirurgia cardíaca foi recentemente remodelado, mas dúvidas referentes à sua metodologia e desenvolvimento têm sido relatadas. Objetivo: O objetivo deste estudo foi avaliar o desempenho do EuroSCORE II na predição de mortalidade e [...] m pacientes submetidos a cirurgia de coronária e/ou valva na instituição. Métodos: Mil pacientes, operados consecutivamente de coronária e/ou valva, entre outubro de 2008 e julho de 2009, foram analisados. O desfecho de interesse foi mortalidade intra-hospitalar. A calibração foi realizada pela correlação entre mortalidade esperada e observada por meio do teste de Hosmer Lemeshow. A discriminação foi calculada pela área abaixo da curva ROC. O desempenho do EuroSCORE II foi comparado com os modelos EuroSCORE e InsCor (modelo local). Resultados: Na calibração, o teste de Hosmer Lemeshow foi inadequado para o EuroSCORE II (P=0,0003) e bom para os modelos EuroSCORE (P=0,593) e InsCor (P=0,184). No entanto, na discriminação, a área abaixo da curva ROC para o EuroSCORE II foi de 0,81 [IC 95% (0,76-0,85), P Abstract in english Introduction: The most widely used model for predicting mortality in cardiac surgery was recently remodeled, but the doubts regarding its methodology and development have been reported. Objective: The aim of this study was to assess the performance of the EuroSCORE II to predict mortality in pati [...] ents undergoing coronary artery bypass grafts or valve surgery at our institution. Methods: One thousand consecutive patients operated on coronary artery bypass grafts or valve surgery, between October 2008 and July 2009, were analyzed. The outcome of interest was in-hospital mortality. Calibration was performed by correlation between observed and expected mortality by Hosmer Lemeshow. Discrimination was calculated by the area under the ROC curve. The performance of the EuroSCORE II was compared with the EuroSCORE and InsCor (local model). Results: In calibration, the Hosmer Lemeshow test was inappropriate for the EuroSCORE II (P=0.0003) and good for the EuroSCORE (P=0.593) and InsCor (P=0.184). However, the discrimination, the area under the ROC curve for EuroSCORE II was 0.81 [95% CI (0.76 to 0.85), P

  6. Safety and reliability criteria

    International Nuclear Information System (INIS)

    Nuclear power plants and, in particular, reactor pressure boundary components have unique reliability requirements, in that usually no significant redundancy is possible, and a single failure can give rise to possible widespread core damage and fission product release. Reliability may be required for availability or safety reasons, but in the case of the pressure boundary and certain other systems safety may dominate. Possible Safety and Reliability (S and R) criteria are proposed which would produce acceptable reactor design. Without some S and R requirement the designer has no way of knowing how far he must go in analysing his system or component, or whether his proposed solution is likely to gain acceptance. The paper shows how reliability targets for given components and systems can be individually considered against the derived S and R criteria at the design and construction stage. Since in the case of nuclear pressure boundary components there is often very little direct experience on which to base reliability studies, relevant non-nuclear experience is examined. (author)

  7. Limitations of electrocardiographic scoring systems for estimation of left ventricular function

    International Nuclear Information System (INIS)

    Four electrocardiographic scoring systems for the assessment of left ventricular function or presence of myocardial infarction were evaluated in 231 patients with coronary artery disease. Electrocardiographic scores were compared with radionuclide ejection fraction and thallium perfusion studies. The correlation between Wagner's modified QRS score and ejection fraction was only fair (r . -0.60). Askenazi's sum of R wave voltage score correlated poorly with ejection fraction (r . 0.44), as did Gottwik's sum of voltage score from the Frank lead electrocardiogram (r . 0.44). Rautaharju's Cardiac Infarction Injury Score did not reliably predict presence of infarction in the patient group, nor did it correlate well with ejection fraction (r . -0.49). None of the correlations were significantly improved when only patients with a history of a myocardial infarction, a thallium defect compatible with a scar or a diagnostic Q wave were considered. Although Wagner's QRS score correlated best with ejection fraction, all scoring systems had limited clinical usefulness for estimating ejection fraction

  8. Observed score equating with covariates

    OpenAIRE

    Bränberg, Kenny

    2010-01-01

    In test score equating the focus is on the problem of finding the relationship between the scales of different test forms. This can be done only if data are collected in such a way that the effect of differences in ability between groups taking different test forms can be separated from the effect of differences in test form difficulty. In standard equating procedures this problem has been solved by using common examinees or common items. With common examinees, as in the equivalent groups des...

  9. Automatic scoring of the severity of psoriasis scaling

    DEFF Research Database (Denmark)

    Gomez, David Delgado; Ersbøll, Bjarne Kjær; Carstensen, Jens Michael

    In this work, a combined statistical and image analysis method to automatically evaluate the severity of scaling in psoriasis lesions is proposed. The method separates the different regions of the disease in the image and scores the degree of scaling based on the properties of these areas. The...... proposed method provides a solution to the lack of suitable methods to assess the lesion and to evaluate changes during the treatment. An experiment over a collection of psoriasis images is conducted to test the performance of the method. Results show that the obtained scores are highly correlated with...

  10. Systemic Sclerosis Classification Criteria: Developing methods for multi-criteria decision analysis with 1000Minds

    Science.gov (United States)

    Johnson, Sindhu R.; Naden, Raymond P.; Fransen, Jaap; van den Hoogen, Frank; Pope, Janet E.; Baron, Murray; Tyndall, Alan; Matucci-Cerinic, Marco; Denton, Christopher P.; Distler, Oliver; Gabrielli, Armando; van Laar, Jacob M.; Mayes, Maureen; Steen, Virginia; Seibold, James R.; Clements, Phillip; Medsger, Thomas A.; Carreira, Patricia E.; Riemekasten, Gabriela; Chung, Lorinda; Fessler, Barri J.; Merkel, Peter A.; Silver, Richard; Varga, John; Allanore, Yannick; Mueller-Ladner, Ulf; Vonk, Madelon C.; Walker, Ulrich A.; Cappelli, Susanna; Khanna, Dinesh

    2014-01-01

    Objective Classification criteria for systemic sclerosis (SSc) are being developed. The objectives were to: develop an instrument for collating case-data and evaluate its sensibility; use forced-choice methods to reduce and weight criteria; and explore agreement between experts on the probability that cases were classified as SSc. Study Design and Setting A standardized instrument was tested for sensibility. The instrument was applied to 20 cases covering a range of probabilities that each had SSc. Experts rank-ordered cases from highest to lowest probability; reduced and weighted the criteria using forced-choice methods; and re-ranked the cases. Consistency in rankings was evaluated using intraclass correlation coefficients (ICC). Results Experts endorsed clarity (83%), comprehensibility (100%), face and content validity (100%). Criteria were weighted (points): finger skin thickening (14–22), finger-tip lesions (9–21), friction rubs (21), finger flexion contractures (16), pulmonary fibrosis (14), SSc-related antibodies (15), Raynaud’s phenomenon (13), calcinosis (12), pulmonary hypertension (11), renal crisis (11), telangiectasia (10), abnormal nailfold capillaries (10), esophageal dilation (7) and puffy fingers (5). The ICC across experts was 0.73 (95%CI 0.58,0.86) and improved to 0.80 (95%CI 0.68,0.90). Conclusions Using a sensible instrument and forced-choice methods, the number of criteria were reduced by 39% (23 to 14) and weighted. Our methods reflect the rigors of measurement science, and serves as a template for developing classification criteria. PMID:24721558

  11. Score lists in multipartite hypertournaments

    CERN Document Server

    Pirzada, Shariefuddin; Iványi, Antal

    2010-01-01

    Given non-negative integers $n_{i}$ and $\\alpha_{i}$ with $0 \\leq \\alpha_{i} \\leq n_i$ $(i=1,2,...,k)$, an $[\\alpha_{1},\\alpha_{2},...,\\alpha_{k}]$-$k$-partite hypertournament on $\\sum_{1}^{k}n_{i}$ vertices is a $(k+1)$-tuple $(U_{1},U_{2},...,U_{k},E)$, where $U_{i}$ are $k$ vertex sets with $|U_{i}|=n_{i}$, and $E$ is a set of $\\sum_{1}^{k}\\alpha_{i}$-tuples of vertices, called arcs, with exactly $\\alpha_{i}$ vertices from $U_{i}$, such that any $\\sum_{1}^{k}\\alpha_{i}$ subset $\\cup_{1}^{k}U_{i}^{\\prime}$ of $\\cup_{1}^{k}U_{i}$, $E$ contains exactly one of the $(\\sum_{1}^{k} \\alpha_{i})!$ $\\sum_{1}^{k}\\alpha_{i}$-tuples whose entries belong to $\\cup_{1}^{k}U_{i}^{\\prime}$. We obtain necessary and sufficient conditions for $k$ lists of non-negative integers in non-decreasing order to be the losing score lists and to be the score lists of some $k$-partite hypertournament.

  12. Laser Safety Inspection Criteria

    International Nuclear Information System (INIS)

    A responsibility of the Laser Safety Officer (LSO) is to perform laser safety audits. The American National Standard Z136.1 Safe use of Lasers references this requirement in several sections: (1) Section 1.3.2 LSO Specific Responsibilities states under Hazard Evaluation, ''The LSO shall be responsible for hazards evaluation of laser work areas''; (2) Section 1.3.2.8, Safety Features Audits, ''The LSO shall ensure that the safety features of the laser installation facilities and laser equipment are audited periodically to assure proper operation''; and (3) Appendix D, under Survey and Inspections, it states, ''the LSO will survey by inspection, as considered necessary, all areas where laser equipment is used''. Therefore, for facilities using Class 3B and or Class 4 lasers, audits for laser safety compliance are expected to be conducted. The composition, frequency and rigueur of that inspection/audit rests in the hands of the LSO. A common practice for institutions is to develop laser audit checklists or survey forms. In many institutions, a sole Laser Safety Officer (LSO) or a number of Deputy LSO's perform these audits. For that matter, there are institutions that request users to perform a self-assessment audit. Many items on the common audit list and the associated findings are subjective because they are based on the experience and interest of the LSO or auditor in particular items on the checklist. Beam block usage is an example; to one set of eyes a particular arrangement might be completely adequate, while to another the installation may be inadequate. In order to provide more consistency, the National Ignition Facility Directorate at Lawrence Livermore National Laboratory (NIF-LLNL) has established criteria for a number of items found on the typical laser safety audit form. These criteria are distributed to laser users, and they serve two broad purposes: first, it gives the user an expectation of what will be reviewed by an auditor, and second, it is an opportunity to explain audit items to the laser user and thus the reasons for some of these items. Some examples are given from the audit criteria handout. As an explanatory key to the reader, an Operational Safety Procedure (OSP) as a formally reviewed safety procedure required for all Class 3B and Class 4 laser installations. An ''OSP Binder'' contains all safety documentation related to a given laser operation and serves as a central repository for documents, such as the OSP, interlock logs, lessons learned, contact information etc. ''Unattended Operation'' refers to approved procedures for unattended operation of the laser installation and may include operation beyond normal working hours. ''L-train'' is the LLNL training tracking system

  13. Decision criteria in PSA applications

    International Nuclear Information System (INIS)

    Along with the adoption of risk informed decision making principles, the need for formal probabilistic decision rule or criteria has been risen. However, there are many practical and theoretical problems in the application of probabilistic criteria. One has to think what is the proper way to apply probabilistic rules together with deterministic ones and how the criteria are weighted with respect to each other. In this report, we approach the above questions from the decision theoretic point of view. We give a short review of the most well known probabilistic criteria, and discuss examples of their use. We present a decision analytic framework for evaluating the criteria, and we analyse how the different criteria behave under incompleteness or uncertainty of the PSA model. As the conclusion of our analysis we give recommendations on the application of the criteria in different decision situations. (au)

  14. Decision criteria in PSA applications

    Energy Technology Data Exchange (ETDEWEB)

    Holmberg, J.E.; Pulkkinen, U.; Rosqvist, T.; Simola, K. [VTT Automation (Finland)

    2001-11-01

    Along with the adoption of risk informed decision making principles, the need for formal probabilistic decision rule or criteria has been risen. However, there are many practical and theoretical problems in the application of probabilistic criteria. One has to think what is the proper way to apply probabilistic rules together with deterministic ones and how the criteria are weighted with respect to each other. In this report, we approach the above questions from the decision theoretic point of view. We give a short review of the most well known probabilistic criteria, and discuss examples of their use. We present a decision analytic framework for evaluating the criteria, and we analyse how the different criteria behave under incompleteness or uncertainty of the PSA model. As the conclusion of our analysis we give recommendations on the application of the criteria in different decision situations. (au)

  15. Evaluation of association between obstructive sleep apnea and coronary risk scores predicted by tomographic coronary calcium scoring in asymptomatic patients

    Directory of Open Access Journals (Sweden)

    Alper Kepez

    2011-08-01

    Full Text Available Objective: This cross-sectional observational study is designed to evaluate direct effects of obstructive sleep apnea syndrome (OSA on presence and extent of coronary atherosclerosis by using tomographic coronary calcification scoring on a population asymptomatic for coronary artery disease.Methods: Ninety-seven consecutive patients (49.17±0.86 years who were evaluated with sleep study for the suspicion of obstructive sleep apnea syndrome underwent tomographic coronary calcium scoring test. Cardiovascular risk factors, current medications and sleep study recordings of all patients were recorded. Patients were classified into 4 groups according to the apnea-hypopnea index (AHI. Linear and logistic regression analyses were used for assessment of association between variables.Results: Coronary risk scores of patients, assessed by tomographic coronary calcium scoring, were observed to increase linearly from simple snoring group to severe OSA groups (p=0.046. When patients were classified according to their gender, AHI and parameters reflecting severity of OSA-related hypoxia were found to correlate significantly with coronary risk scores of women but not with scores of men. Linear regression analysis revealed age as the only independent associated variable with cardiovascular risk scores assessed by tomographic coronary calcification scoring (Beta coefficient: 0.27, 95% CI 0.007-0.087, p=0.018. Binary logistic regression analysis also revealed age as the only variable which independently predicted the presence of coronary calcification (OR:1.11, 95% CI 1.039-1.188, p=0.002.Conclusion: These results suggest that presence of OSA may contribute to coronary artery disease risk of patients in association with its severity; however, association between OSA and subclinical atherosclerosis seems to be primarily dependent on age.

  16. EuroSCORE II and the importance of a local model, InsCor and the future SP-SCORE

    Science.gov (United States)

    Lisboa, Luiz Augusto Ferreira; Mejia, Omar Asdrubal Vilca; Moreira, Luiz Felipe Pinho; Dallan, Luís Alberto Oliveira; Pomerantzeff, Pablo Maria Alberto; Dallan, Luís Roberto Palma; Massoti, Maria Raquel B.; Jatene, Fabio B.

    2014-01-01

    Introduction The most widely used model for predicting mortality in cardiac surgery was recently remodeled, but the doubts regarding its methodology and development have been reported. Objective The aim of this study was to assess the performance of the EuroSCORE II to predict mortality in patients undergoing coronary artery bypass grafts or valve surgery at our institution. Methods One thousand consecutive patients operated on coronary artery bypass grafts or valve surgery, between October 2008 and July 2009, were analyzed. The outcome of interest was in-hospital mortality. Calibration was performed by correlation between observed and expected mortality by Hosmer Lemeshow. Discrimination was calculated by the area under the ROC curve. The performance of the EuroSCORE II was compared with the EuroSCORE and InsCor (local model). Results In calibration, the Hosmer Lemeshow test was inappropriate for the EuroSCORE II (P=0.0003) and good for the EuroSCORE (P=0.593) and InsCor (P=0.184). However, the discrimination, the area under the ROC curve for EuroSCORE II was 0.81 [95% CI (0.76 to 0.85), P<0.001], for the EuroSCORE was 0.81 [95% CI (0.77 to 0.86), P<0.001] and for InsCor was 0.79 [95% CI (0.74-0.83), P<0.001] showing up properly for all. Conclusion The EuroSCORE II became more complex and resemblance to the international literature poorly calibrated to predict mortality in patients undergoing coronary artery bypass grafts or valve surgery at our institution. These data emphasize the importance of the local model. PMID:24896156

  17. Laser Safety Inspection Criteria

    International Nuclear Information System (INIS)

    A responsibility of the Laser Safety Officer (LSO) is to perform laser audits. The American National Standard Z136.1 Safe Use of Lasers references this requirement through several sections. One such reference is Section 1.3.2.8, Safety Features Audits, ''The LSO shall ensure that the safety features of the laser installation facilities and laser equipment are audited periodically to assure proper operation''. The composition, frequency and rigor of that inspection/audit rests in the hands of the LSO. A common practice for institutions is to develop laser audit checklists or survey forms It is common for audit findings from one inspector or inspection to the next to vary even when reviewing the same material. How often has one heard a comment, ''well this area has been inspected several times over the years and no one ever said this or that was a problem before''. A great number of audit items, and therefore findings, are subjective because they are based on the experience and interest of the auditor to particular items on the checklist. Beam block usage, to one set of eyes might be completely adequate, while to another, inadequate. In order to provide consistency, the Laser Safety Office of the National Ignition Facility Directorate has established criteria for a number of items found on the typical laser safety audit form. The criteria are distributed to laser users. It serves two broad purposes; first, it gives the user an expectation of what will be reviewed by an auditor. Second, it is an opportunity to explain audit items to the laser user and thus the reasons for some of these items, such as labelling of beam blocks

  18. Integrated criteria document radon

    International Nuclear Information System (INIS)

    The radon issue is complex and differs from the substances dealt with so far in the series of integrated criteria documents. In chapter 1 general information on the properties of the element radon and a brief description of the existing standards and guidelines is given. In chapter 2 the sources are dealt with and an estimation of the 222Rn and 220Rn emissions in the Netherlands is presented. A general description of the dispersion of radon in the atmosphere and the deposition of radon daughters can be found in Chapter 3 where also the behaviour of radon in the soil and its entry into dwellings is discussed. The measurement techniques for 222Rn and 220Rn in the various environmental compartments, including the important compartment 'air', are presented in Chapter 4. The concentrations observed in the measurement programmes are described in Chapter 5. Chapter 6 includes general information on human toxicity, with the emphasis on dosimetric models and the conversion coefficients from exposure to risk derived from these models. In Chapter 7 human risks and the results of applying the risk coefficients for radon to the exposure of the Dutch population are described. In Chapter 8 a general description of a physical model, specifically developed for the Dutch situation, for the entry of radon into and its behaviour inside a dwelling, is given. This description is included because virtually all control measures proposed for the Netherlands are based on model results. In addition, the control measures which can be applied in the Netherlands are catalogued and their cost-effectiveness is indicated, and a number of policy-relevant scenarios are presented. In Chapter 9 the economic consequences of measures for reducing the radon exposure in the Netherlands are estimated. Finally, in Chapter 10 the information in this integrated criteria document is evaluated. 22 figs., 42 tabs., refs

  19. Scoring of coronary artery calcium scans: history, assumptions, current limitations, and future directions.

    Science.gov (United States)

    Alluri, Krishna; Joshi, Parag H; Henry, Travis S; Blumenthal, Roger S; Nasir, Khurram; Blaha, Michael J

    2015-03-01

    Coronary artery calcium (CAC) scanning is a reliable, noninvasive technique for estimating overall coronary plaque burden and for identifying risk for future cardiac events. Arthur Agatston and Warren Janowitz published the first technique for scoring CAC scans in 1990. Given the lack of available data correlating CAC with burden of coronary atherosclerosis at that time, their scoring algorithm was remarkable, but somewhat arbitrary. Since then, a few other scoring techniques have been proposed for the measurement of CAC including the Volume score and Mass score. Yet despite new data, little in this field has changed in the last 15 years. The main focus of our paper is to review the implications of the current approach to scoring CAC scans in terms of correlation with the central disease - coronary atherosclerosis. We first discuss the methodology of each available scoring system, describing how each of these scores make important indirect assumptions in the way they account (or do not account) for calcium density, location of calcium, spatial distribution of calcium, and microcalcification/emerging calcium that might limit their predictive power. These assumptions require further study in well-designed, large event-driven studies. In general, all of these scores are adequate and are highly correlated with each other. Despite its age, the Agatston score remains the most extensively studied and widely accepted technique in both the clinical and research settings. After discussing CAC scoring in the era of contrast enhanced coronary CT angiography, we discuss suggested potential modifications to current CAC scanning protocols with respect to tube voltage, tube current, and slice thickness which may further improve the value of CAC scoring. We close with a focused discussion of the most important future directions in the field of CAC scoring. PMID:25585030

  20. Sensory Intolerance: Latent Structure and Psychopathologic Correlates

    Science.gov (United States)

    Taylor, Steven; Conelea, Christine A.; McKay, Dean; Crowe, Katherine B.; Abramowitz, Jonathan S.

    2014-01-01

    Background Sensory intolerance refers to high levels of distress evoked by everyday sounds (e.g., sounds of people chewing) or commonplace tactile sensations (e.g., sticky or greasy substances). Sensory intolerance may be associated with obsessive-compulsive (OC) symptoms, OC-related phenomena, and other forms of psychopathology. Sensory intolerance is not included as a syndrome in current diagnostic systems, although preliminary research suggests that it might be a distinct syndrome. Objectives First, to investigate the latent structure of sensory intolerance in adults; that is, to investigate whether it is syndrome-like in nature, in which auditory and tactile sensory intolerance co-occur and are associated with impaired functioning. Second, to investigate the psychopathologic correlates of sensory intolerance. In particular, to investigate whether sensory intolerance is associated with OC-related phenomena, as suggested by previous research. Method A sample of 534 community-based participants were recruited via Amazon.com’s Mechanical Turk program. Participants completed measures of sensory intolerance, OC-related phenomena, and general psychopathology. Results Latent class analysis revealed two classes of individuals: Those who were intolerant of both auditory and tactile stimuli (n = 150), and those who were relatively undisturbed by auditory or tactile stimuli (n = 384). Sensory intolerant individuals, compared to those who were comparatively sensory tolerant, had greater scores on indices of general psychopathology, more severe OC symptoms, a higher likelihood of meeting caseness criteria for OC disorder, elevated scores on measures of OC-related dysfunctional beliefs, a greater tendency to report OC-related phenomena (e.g., a greater frequency of tics), and more impairment on indices of social and occupational functioning. Sensory intolerant individuals had significantly higher scores on OC symptoms even after controlling for general psychopathology. Conclusions Consistent with recent research, these findings provide further evidence for a sensory intolerance syndrome. The findings provide a rationale for conducting future research for determining whether a sensory intolerance syndrome should be included in the diagnostic nomenclature. PMID:24703593

  1. Evaluation of initial diffusion-weighted image findings in acute stroke patients using a semiquantitative score

    International Nuclear Information System (INIS)

    We evaluated the usefulness of rating diffusion-weighted images (DWI) using a semiquantitative score modified from the Alberta Stroke Programme Early CT Score (ASPECTS) to predict deterioration of neurological symptoms in patients with hyperacute ischemic stroke who had undergone thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA). We examined 22 patients with acute stroke (14 men, 8 women, mean age 72.5 years) treated with intravenous rt-PA. All were assessed using the National Institutes of Health Stroke Scale (NIHSS) and underwent emergent magnetic resonance (MR) imaging within 3 hours and 24 hours of stroke onset. Patients were divided into a deteriorated group (16 patients), in which NIHSS scores were increased after thrombolysis, and a non-deteriorated group (6 patients). We compared the DWI score, ASPECTS, and volume of hyperintense ischemic lesion on DWI (DWI volume) of the 2 groups and examined correlations between these scores and initial NIHSS score or DWI volume. The DWI score and ASPECTS tended to be lower in the deteriorated group than the non-deteriorated group. In addition, with a cutoff value ?7, the DWI score could discriminate the deteriorated group from the non-deteriorated group with a sensitivity of 50% and specificity of 87.5%, whereas for ASPECTS, sensitivity was 50% and specificity, 81.2%. The DWI score, ASPECTS, and DWI volume had no correlation with NIHSS score but weak negative correlations with the DWI volume (P<0.01; Spearman's test). Comparing initial NIHSS score with each DWI score and DWI volume, the non-deteriorated group tended to have higher DWI scores and smaller DWI volumes than the deteriorated group, but there was no statistical difference between initial NIHSS and DWI scores. Though the DWI score was not statistically different, the threshold would be set to 6 points or above. Comparing initial DWI score with volume, patients with low DWI scores tended to show large variation in DWI volume and patients with small DWI volume showed large variation in DWI scores. There was no relation between hemorrhagic change and symptoms in either group. The semiquantitative DWI score easily evaluated extent of acute ischemic lesion on DWI and might be used to predict patient outcome after thrombolytic therapy more accurately than ASPECTS or DWI volume. (author)

  2. Pre-validation of the WHO organ dysfunction based criteria for identification of maternal near miss

    Directory of Open Access Journals (Sweden)

    Parpinelli Mary A

    2011-08-01

    Full Text Available Abstract Background To evaluate the performance of the WHO criteria for defining maternal near miss and identifying deaths among cases of severe maternal morbidity (SMM admitted for intensive care. Method Between October 2002 and September 2007, 673 women with SMM were admitted, and among them 18 died. Variables used for the definition of maternal near miss according to WHO criteria and for the SOFA score were retrospectively evaluated. The identification of at least one of the WHO criteria in women who did not die defined the case as a near miss. Organ failure was evaluated through the maximum SOFA score above 2 for each one of the six components of the score, being considered the gold standard for the diagnosis of maternal near miss. The aggregated score (Total Maximum SOFA score was calculated using the worst result of the maximum SOFA score. Sensitivity, specificity, positive and negative predictive values of these WHO criteria for predicting maternal death and also for identifying cases of organ failure were estimated. Results The WHO criteria identified 194 cases of maternal near miss and all the 18 deaths. The most prevalent criteria among cases of maternal deaths were the use of vasoactive drug and the use of mechanical ventilation (?1 h. For the prediction of maternal deaths, sensitivity was 100% and specificity 70.4%. These criteria identified 119 of the 120 cases of organ failure by the maximum SOFA score (Sensitivity 99.2% among 194 case of maternal near miss (61.34%. There was disagreement in 76 cases, one organ failure without any WHO criteria and 75 cases with no failure but with WHO criteria. The Total Maximum SOFA score had a good performance (area under the curve of 0.897 for prediction of cases of maternal near miss according to the WHO criteria. Conclusions The WHO criteria for maternal near miss showed to be able to identify all cases of death and almost all cases of organ failure. Therefore they allow evaluation of the severity of the complication and consequently enable clinicians to build a plan of care or to provide an early transfer for appropriate reference centers.

  3. Pretreatment Beck Depression Inventory score is an important predictor for Post-treatment score in infertile patients: a before-after study

    Directory of Open Access Journals (Sweden)

    Ramezanzadeh Fatemeh

    2005-05-01

    Full Text Available Abstract Background The experience of infertility can be extremely stressful. Some of the risk factors for depression in infertility are being female, repeated unsuccessful treatment cycles or a 2 to 3 year history of infertility, low socioeconomic status, foreign nationality, lack of partner support, life events and previous depression. In this study, we analyzed the Beck Depression Inventory score at the beginning and the end of infertility treatment, to determine which factors may influence the BDI score after treatment of infertility. Methods In a before-after study, in a university-affiliated teaching hospital, 251 women who had been visited for assisted reproductive technology infertility treatment participated in the study. BDI score was assessed before and after treatment of infertility. Results The mean BDI score rose after unsuccessful treatment and dropped after successful treatment. Those with lower education levels had a higher BDI score before treatment. BDI score after treatment was positively correlated with pretreatment BDI scoreand duration of infertility. Conclusion BDI score after treatment was strongly connected to the BDI score before treatment, the result of therapy and to the duration of infertility. The influence of duration of infertility on BDI score after treatment of infertility is weak. So a simple method to screen patients at risk of depression after infertility treatment is determining pretreatment BDI score and predicting the result of infertility treatment by other risk factors.

  4. Scoring system in cirrhotics due to viral hepatitis

    International Nuclear Information System (INIS)

    Objective: To determine the association of serum cholesterol levels with Child-Pugh class in patients with decompensated chronic liver disease due to viral hepatitis. Methodology: Consecutive patients attending outpatient department or admitted in medical unit III were eligible if they had a diagnosis of cirrhosis secondary to viral hepatitis. Patients were excluded if alcoholic, diabetic, hypertensive, or with non-alcoholic fatty liver disease, autoimmune, metabolic, cardiovascular, cerebrovascular or kidney diseases and recent use of lipid-regulating drugs. Serum lipid profile was determined after an overnight fast of 12 hours. On the basis of serum total cholesterol, patients were divided into four groups; Group I with serum total cholesterol = 100 mg/dl, Group II with level of 101-150 mg/dl, Group III with level of 151-200 mg/dl and Group IV with serum total cholesterol level of > 200 mg/dl. Hepatic dysfunction was categorized according to Child-Pugh scoring system. Chi-square and Spearman's correlation testing with p < 0.05 was accepted as significant. Results: One hundred and fourteen patients met the inclusion criteria with a mean age of 40.32 +- 13.59 years. Among these 32 were females (28.1%) while 82 were males (71.9%). According to Child-Pugh class; 34 patients (29.8%) presented with Child-Pugh class A, 34 (29.8%) in class B and 46 (40.4%) were in class C. Serum cholesterol (total) and triglycerides had significant association with Child-Pugh class (p = 0.0001 and p = 0.004 respectively) suggesting that as severity of liver dysfunction increases; serum cholesterol and triglycerides levels decrease. Results also revealed that males were significantly more hypocholesterolemic than females (p = 0.006). Conclusion: Hypocholesterolemia is a common finding in decompensated chronic liver disease and has got significant association with Child-Pugh class. It may increase the reliability of Child-Pugh classification in assessment of severity and prognosis in chronic liver disease patients. (author)

  5. Confidence scores for prediction models

    DEFF Research Database (Denmark)

    Gerds, Thomas Alexander; van de Wiel, MA

    2011-01-01

    In medical statistics, many alternative strategies are available for building a prediction model based on training data. Prediction models are routinely compared by means of their prediction performance in independent validation data. If only one data set is available for training and validation......, then rival strategies can still be compared based on repeated bootstraps of the same data. Often, however, the overall performance of rival strategies is similar and it is thus difficult to decide for one model. Here, we investigate the variability of the prediction models that results when the same...... distinguish rival prediction models with similar prediction performances. Furthermore, on the subject level a confidence score may provide useful supplementary information for new patients who want to base a medical decision on predicted risk. The ideas are illustrated and discussed using data from cancer...

  6. Tailored proper scoring rules elicit decision weights

    OpenAIRE

    Arthur Carvalho

    2015-01-01

    Proper scoring rules are scoring methods that incentivize honest reporting of subjective probabilities, where an agent strictly maximizes his expected score by reporting his true belief. The implicit assumption behind proper scoring rules is that agents are risk neutral. Such an assumption is often unrealistic when agents are human beings. Modern theories of choice under uncertainty based on rank-dependent utilities assert that human beings weight nonlinear utilities usin...

  7. The HEART score for chest pain patients

    OpenAIRE

    Backus, B.E

    2012-01-01

    The HEART score was developed to improve risk stratification in chest pain patients in the emergency department (ED). This thesis describes series of validation studies of the HEART score and sub studies for individual elements of the score. The predictive value of the HEART score for the occurrence of major cardiovascular events (MACE) in chest pain patients in the ED has been determined in a series of four scientific investigations: two retrospective and two prospective studies, mostly ...

  8. Coronary artery calcium scoring in myocardial infarction

    International Nuclear Information System (INIS)

    Background. The aim of this study was to evaluate coronary artery calcium scoring and the assessment of the risk factors in patients with myocardial infarction (MI). Methods. During the period of three years, 27 patients with MI were analyzed. The average age of patients was 66.1 years (46 to 81). Coronary arteries calcium was evaluated by multi row detector computed tomography (MTDC) Somatom Volume Zoom Siemens, and, retrospectively by ECG gating data acquisition. Semi automated calcium quantification to calculate Agatston calcium score (CS) was performed with 4 x 2.5 mm collimation, using 130 ml of contrast medium, injected with an automatic injector, with the flow rate of 4 ml/sec. The delay time was determined empirically. At the same time several risk factors were evaluated. Results. Out of 27 patients with MI, 3 (11.1%) patients had low CS (10- 100), 5 (18.5%) moderate CS (101- 499), and 19 (70.4%) patients high CS (>500). Of risk factors, smoking was confirmed in 17 (63.0%), high blood pressure (HTA) in 10 (57.0%), diabetes mellitus in 7 (25.9%), positive family history in 5 (18.5%), pathological lipids in 5 (18.5%), alcohol abuse in 4 (1.8%) patients. Six (22.2%) patients had symptoms of angina pectoris. Conclusions. The research showed high correlation of MI and high CS (>500). Smoking, HTA, diabetes mellitus, positive family history and hypercholesterolemia are significant risk factors. Symptoms are relatively poor in large number of patients. (author)

  9. Do apparent diffusion coefficient (ADC) values obtained using high b-values with a 3-T MRI correlate better than a transrectal ultrasound (TRUS)-guided biopsy with true Gleason scores obtained from radical prostatectomy specimens for patients with prostate cancer?

    International Nuclear Information System (INIS)

    Objective: To investigate the usefulness of apparent diffusion coefficient (ADC) values in predicting true Gleason scores from radical prostatectomy specimen (tGS), compared with systematic transrectal ultrasound (TRUS)-guided biopsy GS (bGS). Materials and methods: One hundred and five patients with biopsy-proven prostate cancer underwent preoperative DWI (b-values of 0, 1000, and 2000 s/mm2) of 3-T MRI. The mean and minimum ADCs of visible tumors were calculated for either of a pair of b-values: 0 and 1000 s/mm2 (ADC1000), or 0 and 2000 s/mm2 (ADC2000), and relationships between the four ADC parameters and tGS evaluated for the peripheral zone (PZ) and transition zone (TZ). For multiple tumors, the dominant tumor's GS and ADCs were estimated for cancer aggressiveness assessment by computing ROC curves. Results: Significant negative correlations were observed between tGS and mean ADC1000, mean ADC2000, minimum ADC1000, and minimum ADC2000 (r = −0.41, −0.39, −0.39, and −0.37, respectively) of 100 visible PZ tumors and 66 visible TZ tumors (r = −0.40, −0.42, −0.29, and −0.21, respectively). For distinguishing high-grade from low/intermediate-grade PZ lesions, the areas under the curve (AUCs) of mean ADC1000 (0.751), mean ADC2000 (0.710), minimum ADC1000 (0.768), and minimum ADC2000 (0.752) were similar to that of the highest bGS (0.708) (p = 0.61, p = 0.98, p = 0.47, and p = 0.60, respectively). For distinguishing high-grade from low/intermediate-grade TZ lesions, AUCs of mean ADC1000 (0.779), and mean ADC2000 (0.811) were similar to that of the highest bGS (0.805) (p = 0.83 and p = 0.97). Conclusion: Tumor ADCs obtained with high b-values could predict prostate cancer aggressiveness as effectively as systematic TRUS-guided biopsy

  10. Geospatial analysis of HCAHPS pain management experience scores in U.S. hospitals

    OpenAIRE

    Tighe, Patrick J; Fillingim, Roger B.; Hurley, Robert W.

    2014-01-01

    Although prior work has investigated the interplay between demographic and intra-survey correlations of Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) scores, these prior studies have not included geospatial analyses, or analyses which take into account location effects. Here, we report the results of a geospatial analysis (not equivalent to simple geographical analysis) of patient experience scores pertaining to pain.

  11. Evaluation of the appropriateness of prescribing in geriatric patients using Beers criteria and Phadke?s criteria and comparison thereof

    Directory of Open Access Journals (Sweden)

    Rima B Shah

    2011-01-01

    Full Text Available Objectives: To evaluate appropriateness of prescribing medicines in geriatric patients using both Beers criteria and Phadke?s criteria and compare them for validation of Phadke?s criteria as a tool to evaluate rationality of prescribing in elderly. Materials and Methods: A cross-sectional prospective observational study was conducted and the baseline data were collected from different inpatient and outpatient departments in Shree Krishna Hospital (SKH, Karamsad. A total of 400 patients of geriatric age group (?65 years from various inpatient and outpatient departments of SKH were included in the study. Relevant information from patients included in the study was recorded in a structured proforma from their case files. Data were evaluated for appropriateness of prescribing by using both Beers criteria and Phadke?s criteria and comparison between the two criteria was also carried out. Results: Out of total 400 patients, 291 (72.75% patients were prescribed appropriately according to Beers criteria. Based on Phadke?s criteria, 158 (39.5% prescriptions were rational, 129 (32.3% were semirational and 113 (28.3% were irrational. Mean rationality score on a 30-point semiscientific scale was found to be 18.47 ± 9.66 (mean ± SD. The comparison of outcome by both the criteria showed no significant difference in appropriateness of prescribing (P>0.05. Conclusions: Inappropriate prescribing is common in elderly patients. Beers criteria is a well-established method for evaluating appropriateness of prescribing. This study has shown that Phadke?s method of evaluating rationality of prescriptions compares equally well and hence can be a valuable objective tool for assessing appropriateness of prescribing in geriatric patients.

  12. Critical Care Nurses Inadequately Assess SAPS II Scores of Very Ill Patients in Real Life.

    Science.gov (United States)

    Perren, Andreas; Previsdomini, Marco; Perren, Ilaria; Merlani, Paolo

    2012-01-01

    Background. Reliable ICU severity scores have been achieved by various healthcare workers but nothing is known regarding the accuracy in real life of severity scores registered by untrained nurses. Methods. In this retrospective multicentre audit, three reviewers independently reassessed 120 SAPS II scores. Correlation and agreement of the sum-scores/variables among reviewers and between nurses and the reviewers' gold standard were assessed globally and for tertiles. Bland and Altman (gold standard-nurses) of sum scores and regression of the difference were determined. A logistic regression model identifying risk factors for erroneous assessments was calculated. Results. Correlation for sum scores among reviewers was almost perfect (mean ICC = 0.985). The mean (±SD) nurse-registered SAPS II sum score was 40.3 ± 20.2 versus 44.2 ± 24.9 of the gold standard (P 32 points) scores. The lowest agreement was found in high SAPS II tertiles for haemodynamics (k = 0.45-0.51). Conclusions. In real life, nurse-registered SAPS II scores of very ill patients are inaccurate. Accuracy of scores was not associated with nurses' characteristics. PMID:22548157

  13. Developing Score Reports for Cognitive Diagnostic Assessments

    Science.gov (United States)

    Roberts, Mary Roduta; Gierl, Mark J.

    2010-01-01

    This paper presents a framework to provide a structured approach for developing score reports for cognitive diagnostic assessments ("CDAs"). Guidelines for reporting and presenting diagnostic scores are based on a review of current educational test score reporting practices and literature from the area of information design. A sample diagnostic…

  14. Credit Scores, Race, and Residential Sorting

    Science.gov (United States)

    Nelson, Ashlyn Aiko

    2010-01-01

    Credit scores have a profound impact on home purchasing power and mortgage pricing, yet little is known about how credit scores influence households' residential location decisions. This study estimates the effects of credit scores on residential sorting behavior using a novel mortgage industry data set combining household demographic, credit, and…

  15. An ultrasound score for knee osteoarthritis

    DEFF Research Database (Denmark)

    Riecke, B F; Christensen, R.; Torp-Pedersen, S; Boesen, M; Gudbergsen, H; Bliddal, H

    2014-01-01

    OBJECTIVE: To develop standardized musculoskeletal ultrasound (MUS) procedures and scoring for detecting knee osteoarthritis (OA) and test the MUS score's ability to discern various degrees of knee OA, in comparison with plain radiography and the 'Knee injury and Osteoarthritis Outcome Score' (KOOS...

  16. Validation of Automated Scoring of Science Assessments

    Science.gov (United States)

    Liu, Ou Lydia; Rios, Joseph A.; Heilman, Michael; Gerard, Libby; Linn, Marcia C.

    2016-01-01

    Constructed response items can both measure the coherence of student ideas and serve as reflective experiences to strengthen instruction. We report on new automated scoring technologies that can reduce the cost and complexity of scoring constructed-response items. This study explored the accuracy of c-rater-ML, an automated scoring engine…

  17. Analysis of State FFA Degree Scoring.

    Science.gov (United States)

    Barrick, R. Kirby

    1984-01-01

    This study analyzed the scores of the 585 state FFA (Future Farmers of America) degree applications in Ohio in 1982. The study identified sex, year in school, area of state, and program area of applicants; influence of the scoring areas of the application; and relationships among the scoring areas. (CT)

  18. Validating a Prognostic Scoring System for Postmastectomy Locoregional Recurrence in Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Skye Hung-Chun, E-mail: skye@kfsyscc.org [Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); Clinical Research Office, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Tsai, Stella Y. [Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Yu, Ben-Long [Department of Surgery, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); Horng, Cheng-Fang [Clinical Research Office, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); Chen, Chii-Ming [Department of Surgery, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); Jian, James J. [Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Chu, Nan-Min [Department of Medical Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); Tsou, Mei-Hua [Department of Pathology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); Liu, Mei-Ching [Department of Medical Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); Huang, Andrew T. [Department of Medical Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); Department of Medicine, Duke University Medical Center, Durham, North Carolina (United States); Prosnitz, Leonard R. [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States)

    2013-03-15

    Purpose: This study is designed to validate a previously developed locoregional recurrence risk (LRR) scoring system and further define which groups of patients with breast cancer would benefit from postmastectomy radiation therapy (PMRT). Methods and Materials: An LRR risk scoring system was developed previously at our institution using breast cancer patients initially treated with modified radical mastectomy between 1990 and 2001. The LRR score comprised 4 factors: patient age, lymphovascular invasion, estrogen receptor negativity, and number of involved lymph nodes. We sought to validate the original study by examining a new dataset of 1545 patients treated between 2002 and 2007. Results: The 1545 patients were scored according to the previously developed criteria: 920 (59.6%) were low risk (score 0-1), 493 (31.9%) intermediate risk (score 2-3), and 132 (8.5%) were high risk (score ?4). The 5-year locoregional control rates with and without PMRT in low-risk, intermediate-risk, and high-risk groups were 98% versus 97% (P=.41), 97% versus 91% (P=.0005), and 89% versus 50% (P=.0002) respectively. Conclusions: This analysis of an additional 1545 patients treated between 2002 and 2007 validates our previously reported LRR scoring system and suggests appropriate patients for whom PMRT will be beneficial. Independent validation of this scoring system by other institutions is recommended.

  19. Validating a Prognostic Scoring System for Postmastectomy Locoregional Recurrence in Breast Cancer

    International Nuclear Information System (INIS)

    Purpose: This study is designed to validate a previously developed locoregional recurrence risk (LRR) scoring system and further define which groups of patients with breast cancer would benefit from postmastectomy radiation therapy (PMRT). Methods and Materials: An LRR risk scoring system was developed previously at our institution using breast cancer patients initially treated with modified radical mastectomy between 1990 and 2001. The LRR score comprised 4 factors: patient age, lymphovascular invasion, estrogen receptor negativity, and number of involved lymph nodes. We sought to validate the original study by examining a new dataset of 1545 patients treated between 2002 and 2007. Results: The 1545 patients were scored according to the previously developed criteria: 920 (59.6%) were low risk (score 0-1), 493 (31.9%) intermediate risk (score 2-3), and 132 (8.5%) were high risk (score ?4). The 5-year locoregional control rates with and without PMRT in low-risk, intermediate-risk, and high-risk groups were 98% versus 97% (P=.41), 97% versus 91% (P=.0005), and 89% versus 50% (P=.0002) respectively. Conclusions: This analysis of an additional 1545 patients treated between 2002 and 2007 validates our previously reported LRR scoring system and suggests appropriate patients for whom PMRT will be beneficial. Independent validation of this scoring system by other institutions is recommended

  20. 7 CFR 1740.8 - Scoring criteria for the grant competition.

    Science.gov (United States)

    2010-01-01

    ...by multiplying the rural population for the...average of the National School Lunch Program (NSLP...percentages for all school districts within...by the urgency and importance of the project to the rural community the...

  1. Cribriform morphology predicts upstaging after radical prostatectomy in patients with Gleason score 3 + 4 = 7 prostate cancer at transrectal ultrasound (TRUS)-guided needle biopsy.

    Science.gov (United States)

    Keefe, Daniel T; Schieda, Nicola; El Hallani, Soufiane; Breau, Rodney H; Morash, Chris; Robertson, Susan J; Mai, Kien T; Belanger, Eric C; Flood, Trevor A

    2015-10-01

    Selected patients with transrectal ultrasound (TRUS)-guided biopsies containing Gleason score 3?+?4?=?7 prostate cancer (PCa) may be considered candidates for active surveillance (AS). The purpose of this study was to determine if there are features that predict PCa upstaging and/or upgrading after radical prostatectomy (RP) in patients with Gleason score 3?+?4?=?7 PCa diagnosed on TRUS-guided biopsies. We searched our institution's database for patients with Gleason score 3?+?4?=?7 PCa diagnosed on TRUS-guided biopsy who underwent subsequent RP between January 2010 and January 2015. Two blinded genitourinary pathologists independently reviewed and assessed the following on biopsies: (a) nuclear size, nucleolar size and distribution of macronucleoli of PCa, which were subjectively graded using a semi-quantitative scale from 1 to 3, and (b) PCa with cribriform morphology and the size of cribriform disease. Patient age, serum prostate-specific antigen (PSA) and PSA density (PSAD) were also recorded. The Gleason score and stage (presence or absence of organ-confined disease (OCD)) were retrieved from RP reports. Comparisons were performed between groups using the chi-square test and Spearman correlation. One hundred and four patients were identified to have met inclusion criteria. The mean age was 63 (±6.1)?years. Mean PSA and PSAD at diagnosis were 7.5 (±4.2) and 0.25 (±0.15)?ng/mL, respectively. Gleason scores were upgraded to greater than 3?+?4?=?7 in 26.9 % (28/104) of patients, and 44.2 % (46/104) of patients had no OCD after RP. There was no correlation between age, PSA, PSAD or percent of biopsies with Gleason pattern 4 for either Gleason score upgrading or absence of OCD at the time of RP (p?>?0.05). Thirty patients had cribriform morphology on TRUS-guided biopsy of which 60 % (18/30) had no OCD at RP (p?=?0.04) while 36.7 % (11/30) were upgraded to Gleason score ?3?+?4?=?7 after RP (p?=?0.15). There was no association between nuclear size, nucleolar size and/or distribution of macronucleoli with upgrading and/or absence of OCD (p?>?0.05). The size of cribriform pattern was not associated with the absence of OCD (p?=?0.43) or Gleason score upgrade (p?=?0.28). A proportion of patients with Gleason score 3?+?4?=?7 PCa at needle biopsy do not have OCD or are upgraded to higher Gleason scores after RP. In our study, patients with Gleason score 3?+?4?=?7 PCa with the presence of cribriform pattern 4 had a significantly increased chance of being found to have no OCD at the time of RP. There were no clinical or pathologic parameters at the time of TRUS-guided biopsy that identified risk factors for Gleason score upgrading at RP in this study. Cribriform morphology detected on biopsy in patients with Gleason score 3?+?4?=?7 PCa is associated with tumour upstaging after RP and may be considered a contraindication to active surveillance. PMID:26229020

  2. ACR Appropriateness Criteria Myelopathy.

    Science.gov (United States)

    Roth, Christopher J; Angevine, Peter D; Aulino, Joseph M; Berger, Kevin L; Choudhri, Asim F; Fries, Ian Blair; Holly, Langston T; Kendi, Ayse Tuba Karaqulle; Kessler, Marcus M; Kirsch, Claudia F; Luttrull, Michael D; Mechtler, Laszlo L; O'Toole, John E; Sharma, Aseem; Shetty, Vilaas S; West, O Clark; Cornelius, Rebecca S; Bykowski, Julie

    2016-01-01

    Patients presenting with myelopathic symptoms may have a number of causative intradural and extradural etiologies, including disc degenerative diseases, spinal masses, infectious or inflammatory processes, vascular compromise, and vertebral fracture. Patients may present acutely or insidiously and may progress toward long-term paralysis if not treated promptly and effectively. Noncontrast CT is the most appropriate first examination in acute trauma cases to diagnose vertebral fracture as the cause of acute myelopathy. In most nontraumatic cases, MRI is the modality of choice to evaluate the location, severity, and causative etiology of spinal cord myelopathy, and predicts which patients may benefit from surgery. Myelopathy from spinal stenosis and spinal osteoarthritis is best confirmed without MRI intravenous contrast. Many other myelopathic conditions are more easily visualized after contrast administration. Imaging performed should be limited to the appropriate spinal levels, based on history, physical examination, and clinical judgment. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every three years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals, and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances in which evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. PMID:26653797

  3. FHR Generic Design Criteria

    International Nuclear Information System (INIS)

    The purpose of this document is to provide an initial, focused reference to the safety characteristics of and a licensing approach for Fluoride-Salt-Cooled High-Temperature Reactors (FHRs). The document does not contain details of particular reactor designs nor does it attempt to identify or classify either design basis or beyond design basis accidents. Further, this document is an initial attempt by a small set of subject matter experts to document the safety and licensing characteristics of FHRs for a larger audience. The document is intended to help in setting the safety and licensing research, development, and demonstration path forward. Input from a wider audience, further technical developments, and additional study will be required to develop a consensus position on the safety and licensing characteristics of FHRs. This document begins with a brief overview of the attributes of FHRs and then a general description of their anticipated safety performance. Following this, an overview of the US nuclear power plant approval process is provided that includes both test and power reactors, as well as the role of safety standards in the approval process. The document next describes a General Design Criteria (GDC) - based approach to licensing an FHR and provides an initial draft set of FHR GDCs. The document concludes with a description of a path forward toward developing an FHR safety standard that can support both a test and power reactor licensing process.

  4. Vestibular migraine : Diagnostic criteria

    DEFF Research Database (Denmark)

    Lempert, Thomas; Olesen, Jes

    2012-01-01

    This paper presents diagnostic criteria for vestibular migraine, jointly formulated by the Committee for Classification of Vestibular Disorders of the Bárány Society and the Migraine Classification Subcommittee of the International Headache Society (IHS). The classification includes vestibular migraine and probable vestibular migraine. Vestibular migraine will appear in an appendix of the third edition of the International Classification of Headache Disorders (ICHD) as a first step for new entities, in accordance with the usual IHS procedures. Probable vestibular migraine may be included in a later version of the ICHD, when further evidence has been accumulated. The diagnosis of vestibular migraine is based on recurrent vestibular symptoms, a history of migraine, a temporal association between vestibular symptoms and migraine symptoms and exclusion of other causes of vestibular symptoms. Symptoms that qualify for a diagnosis of vestibular migraine include various types of vertigo as well as head motion-induced dizziness with nausea. Symptoms must be of moderate or severe intensity. Duration of acute episodes is limited to a window of between 5 minutes and 72 hours.

  5. ACR appropriateness Criteria® infertility.

    Science.gov (United States)

    Wall, Darci J; Javitt, Marcia C; Glanc, Phyllis; Bhosale, Priyadarshani R; Harisinghani, Mukesh G; Harris, Robert D; Khati, Nadia J; Mitchell, Donald G; Nyberg, David A; Pandharipande, Pari V; Pannu, Harpreet K; Shipp, Thomas D; Siegel, Cary Lynn; Simpson, Lynn; Wong-You-Cheong, Jade J; Zelop, Carolyn M

    2015-03-01

    Appropriate imaging for women undergoing infertility workup depends upon the clinician's suspicion for potential causes of infertility. Transvaginal US is the preferred modality to assess the ovaries for features of polycystic ovary syndrome (PCOS), the leading cause of anovulatory infertility. For women who have a history or clinical suspicion of endometriosis, which affects at least one third of women with infertility, both MRI and pelvic US can provide valuable information. If tubal occlusion is suspected, whether due to endometriosis, previous pelvic inflammatory disease, or other cause, hysterosalpingogram (HSG) is the preferred method of evaluation. To assess for anatomic causes of recurrent pregnancy loss (RPL) such as Müllerian anomalies, synechiae, and leiomyomas, saline infusion sonohysterography, MRI and 3-D US are most appropriate. Up to 10% of women suffering recurrent pregnancy loss have a congenital Müllerian anomaly. When assessment of the pituitary gland is indicated, MRI is the imaging exam of choice.The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every three years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. PMID:25706363

  6. FHR Generic Design Criteria

    Energy Technology Data Exchange (ETDEWEB)

    Flanagan, G.F.; Holcomb, D.E.; Cetiner, S.M.

    2012-06-15

    The purpose of this document is to provide an initial, focused reference to the safety characteristics of and a licensing approach for Fluoride-Salt-Cooled High-Temperature Reactors (FHRs). The document does not contain details of particular reactor designs nor does it attempt to identify or classify either design basis or beyond design basis accidents. Further, this document is an initial attempt by a small set of subject matter experts to document the safety and licensing characteristics of FHRs for a larger audience. The document is intended to help in setting the safety and licensing research, development, and demonstration path forward. Input from a wider audience, further technical developments, and additional study will be required to develop a consensus position on the safety and licensing characteristics of FHRs. This document begins with a brief overview of the attributes of FHRs and then a general description of their anticipated safety performance. Following this, an overview of the US nuclear power plant approval process is provided that includes both test and power reactors, as well as the role of safety standards in the approval process. The document next describes a General Design Criteria (GDC)–based approach to licensing an FHR and provides an initial draft set of FHR GDCs. The document concludes with a description of a path forward toward developing an FHR safety standard that can support both a test and power reactor licensing process.

  7. Documentation of radiation-induced oral mucositis. Scoring Systems

    International Nuclear Information System (INIS)

    Background: Radiation therapy of tumors in the head and neck region is frequently associated with severe side effects in the oral mucosa which often necessitate interruption of the prescribed treatment protocol. In order to compare therapeutic strategies and, more important, in order to perform multicenter studies, generally accepted scoring systems have to be applied for uniform documentation of the oral mucosal response. Methods: Different scoring protocols are found in the literature. The scoring protocols most widely accepted are the CTC classification and the RTOG/EORTC classification. These are compared with more detailed systems. Results: In the CTC classification, grading of stomatitis is included in the responses of the gastrointestinal tract and emphasizes dietary effects. For effects of radiation alone or of radiochemotherapy, the RTOG/EORTC system, focusing on therapeutic interventions, has been established. However, there are only minor differences in the grading of mucositis between these 2 protocols. Based on the RTOG/EORTC classification, Maciejewski et al. introduced a classification system with inclusion of the area affected, but also changed the sensitivity of the scores. The latter may be confusing if the source of the system used is not cited in a report. An alternative system was proposed by Dische, which in addition to objective morphologic criteria also includes the symptoms induced by the mucosal response, and hence includes some subjective aspects reported by the patient. Conclusions: For routine documentation of acute radiation side effects in the oral cavity, the German version of the RTOG/EORTC classification can be recommended. In studies with particular interest in oral mucositis, a more sensitive scoring system may be applied. In any publication concerning mucositis, a table or a detailed description of the system used should be included. (orig.)

  8. A novel scoring system for evaluation of results of autologous transplantation methods in vitiligo

    Directory of Open Access Journals (Sweden)

    Gupta Somesh

    2002-01-01

    Full Text Available Autologous transplantation of melanocyte/melanocytes bearing epidermis for vitiligo can be done by mini-punch grafting (MPG, suction blister epidermal grafting (SBEG, thin split -thickness skin grafting (TSTG, transplantation of basal cell layer enriched suspension and cultured epithelial/melanocyte transplantation. To date no comparative study of these transplantation procedures has been published. Comparison of different studies carried out at different centers may be difficult in the absence of uniform evaluation criteria. In most of the published studies, the results were evaluated in terms of extent of pigmentation. Complictions and color match were evaluated separately. This approach, however, may not give a fair idea about the results. We have developed a scoring system with holistic approach considering the extent of pigmentation, color match and the complications of both the donor and the recipient areas, all taken together. In the scoring system, the score for individual criteria was multiplied with a factor, the value of which was decided on the basis of relative importance of each criteria. The use of this scoring system is exemplified in twelve patients who underwent TSTG, SBEG and MPG. In the scoring system the results were judged as excellent and fair in 3 patients each, as good in 4 patients and as poor in 2 patients.

  9. Proposal of a CT scoring system of the paranasal sinuses in diagnosing cystic fibrosis

    International Nuclear Information System (INIS)

    The purpose of this study was to develop a paranasal sinus CT scoring system that could be used as a diagnostic tool to discriminate cystic fibrosis (CF) patients from control patients examined for sinonasal disease. The model should include as few and easily applicable criteria as possible, supported by statistical analyses and clinical judgement. We used data from 116 CF and 136 control patients. The CF patients were grouped according to the number of confirmed CF mutations: genetically verified (CF-2), or based on sweat testing and clinical findings alone (CF-1, CF-0). Nine paranasal sinus CT criteria, including development, pneumatisation variants and inflammatory patterns, were evaluated. The final model included three criteria: (a) frontal and (b) sphenoid sinus development, and (c) absence of three pneumatisation variants. This model discriminated CF-2 from controls with overlap of summed scores in only 8 of 206 patients. When this model was applied in the CF-1 and CF-0 groups, two populations seemed to exist. A larger group with summed scores overlapping that of the CF-2 group and a smaller group with summed scores overlapping that of the control group. We conclude that this CT scoring system may support, as well as exclude, a CF diagnosis in cases of diagnostic uncertainty. (orig.)

  10. A new diagnostic score to detect osteoporosis in patients undergoing lumbar spine MRI

    Energy Technology Data Exchange (ETDEWEB)

    Bandirali, Michele; Messina, Carmelo [Universita degli Studi di Milano, Scuola di Specializzazione in Radiodiagnostica, Milano (Italy); Di Leo, Giovanni; Papini, Giacomo Davide Edoardo [IRCCS Policlinico San Donato, Radiology Unit, San Donato Milanese (Italy); Sconfienza, Luca Maria; Sardanelli, Francesco [IRCCS Policlinico San Donato, Radiology Unit, San Donato Milanese (Italy); Universita degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, San Donato Milanese (Italy); Ulivieri, Fabio Massimo [IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Mineralometria Ossea Computerizzata e Ambulatorio Malattie Metabolismo Minerale e Osseo, Servizio di Medicina Nucleare, Milano (Italy)

    2015-10-15

    Signal intensity of lumbar-spine at magnetic resonance imaging (MRI) correlates to bone mineral density (BMD). Our aim was to define a quantitative MRI-based score to detect osteoporosis on lumbar-spine MRI. After Ethics Committee approval, we selected female patients who underwent both lumbar-spine MRI and dual-energy X-ray absorptiometry (DXA) and a reference group of 131 healthy females (20-29 years) who underwent lumbar-spine MRI. We measured the intra-vertebral signal-to-noise ratio in L1-L4. We introduced an MRI-based score (M-score), on the model of T-score. M-score diagnostic performance in diagnosing osteoporosis was estimated against DXA using receiver operator characteristic (ROC) analysis. We included 226 patients (median age 65 years), 70 (31 %) being osteoporotic at DXA. MRI signal-to-noise ratio correlated to BMD (r = -0.677, P < 0.001). M-score negatively correlated to T-score (r = -0.682, P < 0.001). Setting a 90 %-specificity, an M-score threshold of 5.5 was found, distinguishing osteoporosis from non-osteoporosis (sensitivity 54 %; ROC AUC 0.844). Thirty-one (14 %) patients had a fragility fracture, with osteoporosis detected in 15 (48 %) according to M-score and eight (26 %) according to T-score (P = 0.016). M-score obtained on lumbar spine MRI is a quantitative method correlating with osteoporosis. Its diagnostic value remains to be demonstrated on a large prospective cohort of patients. (orig.)

  11. A new diagnostic score to detect osteoporosis in patients undergoing lumbar spine MRI

    International Nuclear Information System (INIS)

    Signal intensity of lumbar-spine at magnetic resonance imaging (MRI) correlates to bone mineral density (BMD). Our aim was to define a quantitative MRI-based score to detect osteoporosis on lumbar-spine MRI. After Ethics Committee approval, we selected female patients who underwent both lumbar-spine MRI and dual-energy X-ray absorptiometry (DXA) and a reference group of 131 healthy females (20-29 years) who underwent lumbar-spine MRI. We measured the intra-vertebral signal-to-noise ratio in L1-L4. We introduced an MRI-based score (M-score), on the model of T-score. M-score diagnostic performance in diagnosing osteoporosis was estimated against DXA using receiver operator characteristic (ROC) analysis. We included 226 patients (median age 65 years), 70 (31 %) being osteoporotic at DXA. MRI signal-to-noise ratio correlated to BMD (r = -0.677, P < 0.001). M-score negatively correlated to T-score (r = -0.682, P < 0.001). Setting a 90 %-specificity, an M-score threshold of 5.5 was found, distinguishing osteoporosis from non-osteoporosis (sensitivity 54 %; ROC AUC 0.844). Thirty-one (14 %) patients had a fragility fracture, with osteoporosis detected in 15 (48 %) according to M-score and eight (26 %) according to T-score (P = 0.016). M-score obtained on lumbar spine MRI is a quantitative method correlating with osteoporosis. Its diagnostic value remains to be demonstrated on a large prospective cohort of patients. (orig.)

  12. Preoperative prediction of neurovascular bundle involvement of localized prostate cancer by combined T2 and diffusion-weighted imaging of magnetic resonance imaging, number of positive biopsy cores, and Gleason score.

    Science.gov (United States)

    Naiki, Taku; Okamura, Takehiko; Nagata, Daisuke; Mori, Yuji; Kawai, Noriyasu; Ogawa, Kumiko; Akita, Hidetoshi; Hashimoto, Yoshihiro; Tozawa, Keiichi; Kohri, Kenjiro

    2011-01-01

    Because recovery of erectile function and avoidance of positive surgical margins are important but competing outcomes with prostate cancer therapy, the decision to preserve or resect a neurovascular bundle (NVB) during laparoscopic radical prostatectomy (LRP) should be firmly based on information concerning the presence and location of extracapsular extension. In the current retrospective study, the propriety of actual decisions was assessed using preoperative magnetic resonance imaging (MRI), combining T2-weighted imaging (T2WI) with diffusion-weighted imaging (DWI), the apparent diffusion coefficient (ADC), numbers of positive biopsy cores, tumor volume and the Gleason score. MRI before prostate biopsy was performed in 35 patients who underwent LRP for clinically localized prostate cancer. A single radiologist retrospectively assessed whether the tumor localization, capsular penetration, seminal vesicle invasion, NVB involvement, and MRI findings correlated with the postoperative histological results. With the postoperative specimens, 83 lesions demonstrated a Gleason score of 6 or more. Using T2WI with and without DWI and ADC, 39 and 27 of 54 lesions were correctly identified, respectively, the difference being significant. For cancers in the transitional zone, using a threshold Gleason score of 3 or greater, sensitivity was also significantly higher for T2+DWI+ADC than for T2WI alone. Of 35 patients, using all available clinical information (biopsy results including Gleason score, tumor location, percentage of positive biopsy cores, and the percentage of tumor-involved core tissue), we found that the preoperative and postoperative staging were concordant in 25 cases. There is no universal consensus for nerve-sparing LRP; therefore, we performed an additional analysis using simplified clinically defined selection criteria (PSA level >15ng/mL, cT2, less than two positive biopsy scores in the unilateral lobe and less than 30% tumor volume, and a Gleason score of 6). Using this criteria, we selected 12 of 35 patients, and the detection rate of NVB involvement by MRI combined T2WI + DWI + ADC maps was 100% in their 30 lesions, and therefore we consider it safe to perform nerve-sparing LRP using our criteria. Our findings suggest that NVB can be safely preserved in patients with low-grade tumors using simplified clinically defined selection criteria to determine margin involvement. PMID:21790224

  13. Radioactive waste package acceptance criteria

    International Nuclear Information System (INIS)

    Preliminary acceptance criteria have been developed for packages containing nuclear waste which must be stored or disposed of by the US Department of Energy. Acceptance criteria are necessary to ensure that the waste packages are compatible with all elements of the Waste Management System. The acceptance criteria are subject to revision since many of the constraints that will be imposed on the waste packages by the Waste Management System have either not been defined or are being revised. Delineation of the acceptance criteria will provide bases for handling, transporting and disposing of the commercial waste

  14. Like father, like son? A note on the intergenerational transmission of IQ scores

    OpenAIRE

    Black , Sandra E.; Devereux, Paul J.; Salvanes, Kjell Gunnar

    2008-01-01

    More able parents tend to have more able children. While few would question the validity of this statement, there is little large-scale evidence on the intergenerational transmission of IQ scores. Using a larger and more comprehensive dataset than previous work, we are able to estimate the intergenerational correlation in IQ scores, examining not just average correlations but also how this relationship varies for different subpopulations. We find that there is substantial intergenerational tr...

  15. Like father, like son? A note on the intergenerational transmission of IQ scores

    OpenAIRE

    Devereux, Paul J.

    2008-01-01

    More able parents tend to have more able children. While few would question the validity of this statement, there is little large-scale evidence on the intergenerational transmission of IQ scores. Using a larger and more comprehensive dataset than previous work, we are able to estimate the intergenerational correlation in IQ scores, examining not just average correlations but also how this relationship varies for different subpopulations. We find that there is substantial intergenerational...

  16. Comparison of Selvester QRS score with magnetic resonance imaging measured infarct size in patients with ST elevation myocardial infarction

    DEFF Research Database (Denmark)

    Carlsen, Esben A; Bang, Lia E

    2012-01-01

    Recent studies have shown that the Selvester QRS score is significantly correlated with delayed enhancement-magnetic resonance imaging (DE-MRI) measured myocardial infarct (MI) size in reperfused ST elevation MI (STEMI). This study further tests the hypothesis that Selvester QRS score correlates well with MI size determined by DE-MRI in reperfused STEMI.

  17. How does emergency department overcrowding affect medical student test scores and clerkship evaluations?

    Directory of Open Access Journals (Sweden)

    Grant Wei

    2015-11-01

    Full Text Available Introduction: The effect of emergency department (ED crowding has been recognized as a concern for more than 20 years; its effect on productivity, medical errors, and patient satisfaction has been studied extensively. Little research has reviewed the effect of ED crowding on medical education. Prior studies that have considered this effect have shown no correlation between ED crowding and resident perception of quality of medical education. Objective: To determine whether ED crowding, as measured by the National ED Overcrowding Scale (NEDOCS score, has a quantifiable effect on medical student objective and subjective experiences during emergency medicine (EM clerkship rotations. Methods: We collected end-of-rotation examinations and medical student evaluations for 21 EM rotation blocks between July 2010 and May 2012, with a total of 211 students. NEDOCS scores were calculated for each corresponding period. Weighted regression analyses examined the correlation between components of the medical student evaluation, student test scores, and the NEDOCS score for each period. Results: When all 21 rotations are included in the analysis, NEDOCS scores showed a negative correlation with medical student tests scores (regression coefficient= -0.16, p=0.04 and three elements of the rotation evaluation (attending teaching, communication, and systems-based practice; p<0.05. We excluded an outlying NEDOCS score from the analysis and obtained similar results. When the data were controlled for effect of month of the year, only student test score remained significantly correlated with NEDOCS score (p=0.011. No part of the medical student rotation evaluation attained significant correlation with the NEDOCS score (p?0.34 in all cases. Conclusion: ED overcrowding does demonstrate a small but negative association with medical student performance on end-of-rotation examinations. Additional studies are recommended to further evaluate this effect.

  18. Design criteria and analysis methods for a CIRENE reactor core

    International Nuclear Information System (INIS)

    This paper describes the design criteria and the analysis methods of a CIRENE reactor core. The design criteria are based on thermal-hydraulic considerations, and imply, in particular, a limitation of the Minimum Critical Power Ratio for the fuel channel. A survey is given in this paper of the validity of the adopted thermal-hydraulics correlations and the main neutronic and thermal-hydraulic calculation tools are illustrated, the accuracy and efficiency of which are also indicated

  19. Bispectral index score and observer?s assessment of awareness/sedation score may manifest divergence during onset of sedation: Study with midazolam and propofol

    Directory of Open Access Journals (Sweden)

    Dipanjan Bagchi

    2013-01-01

    Full Text Available Background: Correlation between the clinical and electroencephalogram-based monitoring has been documented sporadically during the onset of sedation. Propofol and midazolam have been studied individually using the observer?s assessment of awareness/sedation (OAA/S score and Bispectral index score (BIS. The present study was designed to compare the time to onset of sedation for propofol and midazolam using both BIS and OAA/S scores, and to find out any correlation. Methods: A total of 46 patients (18-60 years, either sex, American Society of Anesthesiologists (ASA I/II posted for infraumbilical surgeries under spinal anaesthesia were randomly allocated to receive either injection propofol 1 mg/kg bolus followed by infusion 3 mg/kg/h (Group P, n=23 or injection midazolam 0.05 mg/kg bolus followed by infusion 0.06 mg/kg/h (Group M, n=23. Spinal anaesthesia was given with 2.5 ml to 3.0 ml of 0.5% bupivacaine heavy. When sensory block reached T6 level, sedation was initiated. The time to reach BIS score 70 and time to achieve OAA/S score 3 from the start of study drug were noted. OAA/S score at BIS score 70 was noted. Data from 43 patients were analyzed using SPSS 12 for Windows. Results: Time to reach BIS score 70 using propofol was significantly lower than using the midazolam (P<0.05. Time to achieve OAA/S score 3 using propofol was comparable with midazolam (P=0.358. Conclusion: A divergence exists between the time to reach BIS score 70 and time to achieve OAA/S score 3 using midazolam, compared with propofol, during the onset of sedation.

  20. Score Function of Distribution and Heavy-Tails.

    Czech Academy of Sciences Publication Activity Database

    Fabián, Zden?k

    Geneva : Centre International de Conferences, 2014 - (Gilli, M.; Nieto-Reyes, A.; González-Rodríguez, G.), s. 657-664 ISBN 978-2-8399-1347-8. [COMPSTAT 2014. International Conference on Computational Statistics /21./. Geneva (CH), 19.08.2014-22.08.2014] R&D Projects: GA MŠk(CZ) LG12020 Institutional support: RVO:67985807 Keywords : score function * point estimation * correlation * heavy-tailed distributions Subject RIV: BB - Applied Statistics , Operational Research

  1. Development of the knowledge-based and empirical combined scoring algorithm (KECSA) to score protein-ligand interactions.

    Science.gov (United States)

    Zheng, Zheng; Merz, Kenneth M

    2013-05-24

    We describe a novel knowledge-based protein-ligand scoring function that employs a new definition for the reference state, allowing us to relate a statistical potential to a Lennard-Jones (LJ) potential. In this way, the LJ potential parameters were generated from protein-ligand complex structural data contained in the Protein Databank (PDB). Forty-nine (49) types of atomic pairwise interactions were derived using this method, which we call the knowledge-based and empirical combined scoring algorithm (KECSA). Two validation benchmarks were introduced to test the performance of KECSA. The first validation benchmark included two test sets that address the training set and enthalpy/entropy of KECSA. The second validation benchmark suite included two large-scale and five small-scale test sets, to compare the reproducibility of KECSA, with respect to two empirical score functions previously developed in our laboratory (LISA and LISA+), as well as to other well-known scoring methods. Validation results illustrate that KECSA shows improved performance in all test sets when compared with other scoring methods, especially in its ability to minimize the root mean square error (RMSE). LISA and LISA+ displayed similar performance using the correlation coefficient and Kendall ? as the metric of quality for some of the small test sets. Further pathways for improvement are discussed for which would allow KECSA to be more sensitive to subtle changes in ligand structure. PMID:23560465

  2. Flux selection criteria

    International Nuclear Information System (INIS)

    Full text: The XRF analysis is a method based on comparison of a sample with standards of calibration. All things being equal the accuracy of XRF analysis depends of the sample preparation method. In order to obtain the most reliable and the most accurate analysis results, the specimen to be analysed must have the same overall composition chemical and physical as the control standards. The fusion technique based on a homogeneous dissolution and dispersion of oxides in an appropriate flux eliminates matrix effect and the various undesirable effects due to the heterogeneity of a powder. According to the laboratory equipment and the nature of the sample to be analysed the various parameters to obtain a homogeneous bead will be examined. The selection criteria, of the most appropriate flux of system of flux in relation with the expected results, will be discussed. The choice of a particular flux or mixture of flux depends not only on the acido-basic character of the specimen to be analysed but also on the temperature of fusion. Anhydrous homogeneous pre-fused fluxes and mixture of fused fluxes with additives having practically no loss of increase the quality of the final results. The particles size distribution of the flux improves the dissolution and homogenisation rate. The free flowing and non-dusty characteristic of the anhydrous pre-fused flux are perfectly suitable for automatic weighing system and safety. Additives may improve the process and in particular the addition of halides to avoid sticking and cracking of beads. Suggestions for the treatment of difficult samples such as ferro alloys, ores and high silicium content samples will be given. Pre-oxidation with various nitrates for samples containing reduced species and sulphur will be discussed. The use of high purity fluxes increases the accuracy of analysis of light or trace elements. Copyright (1999) Australian X-ray Analytical Association Inc

  3. Prognóstico dos casos de pancreatite aguda pelo escore de PANC 3 / Prognosis of acute pancreatitis by PANC 3 score

    Scientific Electronic Library Online (English)

    James Ken, Fukuda; Orli, Franzon; Fernando de Oliveira, Resende-Filho; Nicolau Fernandes, Kruel; Thiago Alessandro, Ferri.

    2013-06-01

    Full Text Available RACIONAL: A pancreatite aguda é doença de grande importância na prática clínica, definida como inflamação do pâncreas podendo levar ao envolvimento de tecidos locais ou acometimento de outros órgãos de forma sistêmica, necessitando nesses casos de cuidados em terapia intensiva. OBJETIVO: Analisar o [...] sistema simplificado de estratificação de PANC 3, correlacionando-o com o escore de Ranson para definição prognóstica de casos de pancreatite aguda. MÉTODO: Foi realizado um estudo observacional, prospectivo em que foram avaliados 65 pacientes que foram diagnosticados com quadro de pancreatite aguda. RESULTADOS: Obteve para o PANC 3 sensibilidade de 31,25%; especificidade de 100%; valor preditivo positivo de 100%; valor preditivo negativo de 81,66% e acurácia de 83,07%. CONCLUSÕES: Os critérios de PANC 3 têm sua validade na definição de gravidade e prognóstico da pancreatite aguda, não como método substituto, mas como método a ser associado aos critérios de Ranson, principalmente pela sua alta acurácia, valor preditivo positivo e especificidade. Abstract in english BACKGROUND: Acute pancreatitis is a disease of great importance in clinical practice, defined as an inflammatory process of the pancreas that may involve local tissues or affect other organs in a systemic manner, requiring, in such cases, an intensive care. AIM: To analyze the simplified stratificat [...] ion system of the PANC 3 score, correlating it with the Ranson score, for the prognostic definition of cases of acute pancreatitis. METHOD: Was conducted a prospective, observational study in which were evaluated 65 patients who were diagnosed with acute pancreatitis. RESULTS: PANC 3 showed sensitivity, 31.25%; specificity,100%; positive predictive value, 100%; negative predictive value, 81.66% and accuracy, 83.07%. CONCLUSIONS: The PANC 3 criteria are applicable to define the severity and the prognosis of acute pancreatitis, and are not a substitute method, but rather a method to be associated with the Ranson criteria, mainly due to its high accuracy, positive predictive value and specificity.

  4. Relationship between motor performance and physical fitness score in 7- to 8-year-old children. DOI: 10.5007/1980-0037.2011v13n2p94

    Directory of Open Access Journals (Sweden)

    Patrik Felipe Nazario

    2011-03-01

    Full Text Available There are many tests for the evaluation of motor performance or physical fitness that take into account different criteria such as movement forms and patterns, time, distance, and repetitions of each task for the analysis of performance. The aim of this study was to investigate the relationship between motor performance and physical fitness scores in children. Fifty children of both genders aged 7 to 8 years (25 boys and 25 girls participated in this study. The Test of Gross Motor Development – Second Edition (TGMD-2 was used for the evaluation of motor performance. Physical fitness was assessed by three specific tests proposed by the American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD. The results showed statistical significance and weak correlations among some skills such as run, horizontal jump, hop, leap, underhand roll, and medicine ball throw. The equivalent use of both tests may not be adequate since each test has its own peculiarities in terms of assessment criteria.

  5. Thyroid hormone profile and PELOD score in children with sepsis

    Directory of Open Access Journals (Sweden)

    Agung G. Tanurahardja

    2014-07-01

    Full Text Available Background Thyroid hormonal dysfunction, also known as euthyroid sick syndrome or nonthyroidal illness, can be seen in sepsis. There have been few studies on thyroid hormone dysfunction in septic children, as well as on a relationship between their thyroid hormone profiles and pediatric logistic organ dysfunction (PELOD scores. Procalcitonin (PCT is one of the sepsis biomarker. Objective To evaluate the thyroid hormone profile in children with sepsis as well as to assess for a correlation between the thyroid levels and PELOD scores, PCT levels, and patient outcomes. Methods This cross-sectional study included children aged 1-18 years admitted to the pediatric intensive care unit (PICU with a primary diagnosis of sepsis. PELOD scores and thyroid hormonal levels were assessed once during the first 24 hours after PICU admission. Results Thirty subjects were included in the study. The median values of T3, free T4, and TSH were 45 (range 17-133 ng/dL, 0.81 (range 0.3-1.57 ng/dL, and 1.36 (range 0.05-7.78 ?IU/L, respectively. The T3, free T4, and TSH levels were decreased in 97%, 50% and 40% of the subjects. There were no significant differences between low and normal to high TSH with regards to the PELOD score (P=0.218, PCT level (P=0.694, or patient outcomes (P=0.55. The risk of death increased by 15 times among the subjects with PELOD score >20 compared to those with PELOD score <20 (OR 15; 95%CI: 1.535 to 146.545; P=0.012. Conclusion Thyroid hormones are decreased in septic children with the majority having low T3. A high PELOD score is strongly correlated with mortality and can be used as a prognostic parameter for septic children in the PICU, but there is no correlation with decreased TSH.[Paediatr Indones. 2014;54:245-50.].

  6. New Criteria to Identify Spectrum

    Indian Academy of Sciences (India)

    A Jensen; M Krishna

    2005-05-01

    In this paper we give some new criteria for identifying the components of a probability measure, in its Lebesgue decomposition. This enables us to give new criteria to identify spectral types of self-adjoint operators on Hilbert spaces, especially those of interest.

  7. Peer Assessment without Assessment Criteria

    Science.gov (United States)

    Jones, Ian; Alcock, Lara

    2014-01-01

    Peer assessment typically requires students to judge peers' work against assessment criteria. We tested an alternative approach in which students judged pairs of scripts against one another in the absence of assessment criteria. First year mathematics undergraduates (N?=?194) sat a written test on conceptual understanding of multivariable…

  8. Clinical correlates of high intraprostatic brachytherapy dose volumes

    International Nuclear Information System (INIS)

    Purpose: To determine if high intraprostatic dose regions correlate with postimplant urinary or rectal morbidity, potentially providing some objective basis for recommendations regarding dose homogeneity. Methods: Eighty-two patients with 1997 AJC clinical stage T1c-T2a prostatic carcinoma (Gleason Grade 2-6, PSA 4-10 ng/ml) were randomized to implantation with 125I (144 Gy) vs. 103Pd (125 Gy, NIST-1999). Isotope implantation was performed by standard techniques, using a modified peripheral loading pattern. The 125I source strength ranged from 0.4 to 0.89 mCi (median: 0.55 mCi), and the 103Pd source strength ranged from 1.3 to 1.6 mCi (median: 1.5 mCi). The total number of 125I sources implanted ranged from 30 to 186 (median: 69). The total number of 103Pd sources ranged from 60 to 182 (median: 106). A postimplant computed tomography scan was obtained within 2 to 4 hours postimplant. The V100, V200, and V300s were calculated as the percent of the total prostate receiving greater than two, three, or four times the prescription dose, respectively. Treatment-related morbidity was monitored by mailed questionnaires using standard American Urologic Association and Radiation Therapy Oncology Group criteria at 1, 3, 6, 12, and 24 months. The ?AUA score was taken as the AUA (American Urologic Association) score at the time of interest minus the preimplant score. Results: The mean V100, V200, and V300 were 90% (±8%), 35% (±13%), and 14% (±7%), respectively. Higher-dose parameters (V300) correlated more closely with each other than lower-dose parameters. The ?AUA at 1 month had increasing association with higher-dose volumes, the closest association being with V300. However, there was substantial scatter in the data, as evidenced by the low r values. There was no correlation between high-dose volumes and ?AUA at 12 months. Urinary morbidity scores were greatest at the 1-month time point, with no correlation between urinary morbidity and high-dose volumes. There was no correlation between rectal morbidity and high-dose volumes. Conclusion: Expending substantial effort to monitor and modify higher-dose volumes, at least in the setting of modified peripheral loading patterns, is unlikely to substantially decrease implant-related morbidity

  9. User perspectives on relevance criteria

    DEFF Research Database (Denmark)

    Maglaughlin, Kelly L.; Sonnenwald, Diane H.

    2002-01-01

    , partially relevant, or not relevant to their information need; and explained their decisions in an interview. Analysis revealed 29 criteria, discussed positively and negatively, that were used by the participants when selecting passages that contributed or detracted from a document's relevance. These...... implications for relevance feedback in information retrieval systems, suggesting that systems accept and utilize multiple positive and negative relevance criteria from users. Systems designers may want to focus on supporting content criteria followed by full text criteria as these may provide the greatest cost...... criteria can be grouped into six categories: abstract (e.g., citability, informativeness), author (e.g., novelty, discipline, affiliation, perceived status), content (e.g., accuracy/validity, background, novelty, contrast, depth/scope, domain, citations, links, relevant to other interests, rarity, subject...

  10. Breast diagnosis: Concordance analysis between the BI-RADS classification and Tsukuba sonoelastography score

    Directory of Open Access Journals (Sweden)

    Maria Magdalena Duma

    2014-11-01

    Full Text Available Aims. To establish the correlations between the ultrasound (US BI-RADS classification and Tsukuba elastography score when assessing breast lesions. To determine which type of breast lesion (BI-RADS category would benefit most from an elastographic assessment.Patients and Methods. The investigated sample of imaging comprised a number of 129 images belonging to 92 subjects examined with a Hitachi 8500 US device. Each lesion was assessed according to the BI-RADS and Tsukuba elastography score. Histopathology was obtained by means of percutaneous biopsy or post-surgery. Fibroadenoma-like lesions unchanged over a period of 3 years were considered benign.Results. The 1, 2 and BGR Tsukuba scores mostly correlated with BI-RADS II and III lesions such as cysts, hamartomas, lipomas, hematomas, non-palpable fibroadenomas. Palpable fibroadenomas initially included in BI-RADS IVa/b category, usually received benign elasticity scores (1 or 2, the exception being represented by a minority of cases of old, fibrotic or calcified lesions (elastic score 3 or 4. Non-specific  BI-RADS IVa/b lesions, such as mastopathic nodules demonstrated rather soft, elastic properties on elastogram (score 1 or 2. The 4 and 5 Ueno-Itoh scores were predominantly correlated with BI-RADS IVc and V categories represented by high risk lesions (radial scar, papillomas, atypical epithelial ductal hyperplasia and in situ or invasive carcinomas.Conclusions. Generally the BI-RADS classification correlates well with the Tsukuba elasticity score, the main exception being represented by fibrotic, calcified lesions which falsely appear more suspicious post-elastography. BI-RADS III and IV lesions would benefit most from an elastographic assessment, a low Tsukuba score allowing a less invasive approach, while a high score imposes histopathological evaluation. 

  11. Radiographic scoring methods in psoriatic arthritis.

    Science.gov (United States)

    Wassenberg, Siegfried

    2015-01-01

    Psoriatic arthritis (PsA) leads to structural damage that can be an important driver for disability and handicap associated with the disease. Serial radiographs, usually of hands and feet, facilitate follow-up documentation of development of these changes. Semi-quantitative scoring methods are designed to measure the degree of radiographically detectable joint damage, and of changes over time. Several radiographic scoring methods that had been developed originally for rheumatoid arthritis have been adopted for the use in PsA. Four different scoring methods used in PsA are presented with instructions on how to use them: modified Steinbrocker global scoring method; PsA scoring method based on Sharp method for RA; Sharp van der Heijde modified method; and PsA Ratingen score (PARS). Available data on the reliability, sensitivity to change, and use in clinical trials, of these four methods are presented. PMID:26472605

  12. [The diagnostic scores for deep venous thrombosis].

    Science.gov (United States)

    Junod, A

    2015-08-26

    Seven diagnostic scores for the deep venous thrombosis (DVT) of lower limbs are analyzed and compared. Two features make this exer- cise difficult: the problem of distal DVT and of their proximal extension and the status of patients, whether out- or in-patients. The most popular score is the Wells score (1997), modi- fied in 2003. It includes one subjective ele- ment based on clinical judgment. The Primary Care score 12005), less known, has similar pro- perties, but uses only objective data. The pre- sent trend is to associate clinical scores with the dosage of D-Dimers to rule out with a good sensitivity the probability of TVP. For the upper limb DVT, the Constans score (2008) is available, which can also be coupled with D-Dimers testing (Kleinjan). PMID:26502582

  13. Random Walk Picture of Basketball Scoring

    CERN Document Server

    Gabel, Alan

    2011-01-01

    We present evidence, based on play-by-play data from all 6087 games from the 2006/07--2009/10 seasons of the National Basketball Association (NBA), that basketball scoring is well described by a weakly-biased continuous-time random walk. The time between successive scoring events follows an exponential distribution, with little memory between different scoring intervals. Using this random-walk picture that is augmented by features idiosyncratic to basketball, we account for a wide variety of statistical properties of scoring, such as the distribution of the score difference between opponents and the fraction of game time that one team is in the lead. By further including the heterogeneity of team strengths, we build a computational model that accounts for essentially all statistical features of game scoring data and season win/loss records of each team.

  14. Efficient entanglement criteria beyond Gaussian limits using Gaussian measurements.

    Science.gov (United States)

    Nha, Hyunchul; Lee, Su-Yong; Ji, Se-Wan; Kim, M S

    2012-01-20

    We present a formalism to derive entanglement criteria beyond the Gaussian regime that can be readily tested by only homodyne detection. The measured observable is the Einstein-Podolsky-Rosen (EPR) correlation. Its arbitrary functional form enables us to detect non-Gaussian entanglement even when an entanglement test based on second-order moments fails. We illustrate the power of our experimentally friendly criteria for a broad class of non-Gaussian states under realistic conditions. We also show rigorously that quantum teleportation for continuous variables employs a specific functional form of EPR correlation. PMID:22400723

  15. Tame and Wild Scoring Play Games

    OpenAIRE

    Stewart, Fraser

    2013-01-01

    In this paper, we will be proving mathematically that scoring play combinatorial game theory covers all combinatorial games. That is, there is a sub-set of scoring play games that are identical to the set of normal play games, and a different sub-set that is identical to the set of mis\\`ere play games. This proves conclusively, that scoring play combinatorial game theory is a complete theory for combinatorial games, and that every combinatorial game, regardless of the r...

  16. Interval Estimation for the 'Net Promoter Score'

    OpenAIRE

    Rocks, Brendan

    2016-01-01

    The Net Promoter Score (NPS) is a novel summary statistic used by thousands of companies as a key performance indicator of customer loyalty. While adoption of the statistic has grown rapidly over the last decade, there has been little published on its statistical properties. Common interval estimation techniques are adapted for use with the NPS, and performance assessed on the largest available database of companies' Net Promoter Scores. Variations on the Adjusted Wald, and an iterative Score...

  17. Scoring Play Combinatorial Games Under Different Operators

    CERN Document Server

    Stewart, Fraser

    2012-01-01

    Scoring play games were first studied by Fraser Stewart for his PhD thesis. He showed that under the disjunctive sum, scoring play games are partially ordered, but do not have the same "nice" structure of normal play games. In this paper I will be considering scoring play games under three different operators given by John Conway and William Stromquist and David Ullman, namely the conjunctive sum, selective sum and sequential join.

  18. Random Walk Picture of Basketball Scoring

    OpenAIRE

    Gabel, Alan; Redner, S

    2011-01-01

    We present evidence, based on play-by-play data from all 6087 games from the 2006/07--2009/10 seasons of the National Basketball Association (NBA), that basketball scoring is well described by a weakly-biased continuous-time random walk. The time between successive scoring events follows an exponential distribution, with little memory between different scoring intervals. Using this random-walk picture that is augmented by features idiosyncratic to basketball, we account for a wide variety of ...

  19. Waterlow score as a surrogate marker for predicting adverse outcome in acute pancreatitis.

    Science.gov (United States)

    Gillick, K; Elbeltagi, H; Bhattacharya, S

    2016-01-01

    Introduction Introduced originally to stratify risk for developing decubitus ulcers, the Waterlow scoring system is recorded routinely for surgical admissions. It is a composite score, reflecting patients' general condition and co-morbidities. The aim of this study was to investigate whether the Waterlow score can be used as an independent surrogate marker to predict severity and adverse outcome in acute pancreatitis. Methods In this retrospective analysis, a consecutive cohort was studied of 250 patients presenting with acute pancreatitis, all of whom had their Waterlow score calculated on admission. Primary outcome measures were length of hospital stay and mortality. Secondary outcome measures included rate of intensive care unit (ICU) admission and development of complications such as peripancreatic free fluid, pancreatic necrosis and pseudocyst formation. Correlation of the Waterlow score with some known markers of disease severity and outcomes was also analysed. Results The Waterlow score correlated strongly with the most commonly used marker of disease severity, the Glasgow score (analysis of variance, p=0.0012). Inpatient mortality, rate of ICU admission and length of hospital stay increased with a higher Waterlow score (Mann-Whitney U test, p=0.0007, p=0.049 and p=0.0002 respectively). There was, however, no significant association between the Waterlow score and the incidence of three known complications of pancreatitis: presence of peripancreatic fluid, pancreatic pseudocyst formation and pancreatic necrosis. Receiver operating characteristic curve analysis demonstrated good predictive power of the Waterlow score for mortality (area under the curve [AUC]: 0.73), ICU admission (AUC: 0.65) and length of stay >7 days (AUC: 0.64). This is comparable with the predictive power of the Glasgow score and C-reactive protein. Conclusions The Waterlow score for patients admitted with acute pancreatitis could provide a useful tool in prospective assessment of disease severity, help clinicians with appropriate resource management and inform patients. PMID:26688403

  20. Scoring Function Based on Weighted Residue Network

    Directory of Open Access Journals (Sweden)

    Shan Chang

    2011-12-01

    Full Text Available Molecular docking is an important method for the research of protein-protein interaction and recognition. A protein can be considered as a network when the residues are treated as its nodes. With the contact energy between residues as link weight, a weighted residue network is constructed in this paper. Two weighted parameters (strength and weighted average nearest neighbors’ degree are introduced into this model at the same time. The stability of a protein is characterized by its strength. The global topological properties of the protein-protein complex are reflected by the weighted average nearest neighbors’ degree. Based on this weighted network model and these two parameters, a new docking scoring function is proposed in this paper. The scoring and ranking for 42 systems’ bound and unbounded docking results are performed with this new scoring function. Comparing the results obtained from this new scoring function with that from the pair potentials scoring function, we found that this new scoring function has a similar performance to the pair potentials on some items, and this new scoring function can get a better success rate. The calculation of this new scoring function is easy, and the result of its scoring and ranking is acceptable. This work can help us better understand the mechanisms of protein-protein interactions and recognition.

  1. Principles and Criteria for Design

    DEFF Research Database (Denmark)

    Beghin, D.; Cervetto, D.; Hansen, Peter Friis

    1997-01-01

    The mandate of ISSC Committee IV.1 on principles and Criteria for Design is to report on the following:The ongoing concern for quantification of general economic and safety criteria for marine structures and for the development of appropriate principles for rational life cycle design using such...... criteria. Reassessment of existing structures shall also be addressed. Special attention shall be given to issues affecting code formulation and development, with accounting of all uncertainties affecting actual structural behaviour.The emphasis is on ships, with offshore structures teated primarily to...

  2. The correlation between cardiovascular risk and functional disability and disease activity in the patients with rheumatoid arthritis

    OpenAIRE

    Güler, Mustafa; UMUT, Saadet YAZGAN; Teoman AYDIN; REZVAN?, Aylin; POYRAZ, Emine

    2013-01-01

    To determine the cardiovascular risk (CVR) in patients with rheumatoid arthritis (RA) and its correlation with disease activity and functional ability by using the Framingham risk score (FRS) and to compare the CVR of the RA patients with the control group with the help of the FRS. Materials and methods: Seventy-four RA patients, who were in conformity with the criteria of the American College of Rheumatology, were included in this study at Bezmialem Vak?f University Hospital. A total of 39...

  3. On-farm animal welfare assessment in beef bulls: consistency over time of single measures and aggregated Welfare Quality(®) scores.

    Science.gov (United States)

    Kirchner, M K; Schulze Westerath, H; Knierim, U; Tessitore, E; Cozzi, G; Winckler, C

    2014-03-01

    Consistency over time of (on-farm) animal welfare assessment systems forms part of reliability, meaning that results of the assessment should be representative of the longer-term welfare state of the farm as long as the housing and management conditions have not changed considerably. This is especially important if assessments are to be used for certification purposes. It was the aim of the present study to investigate consistency over time of the Welfare Quality(®) (WQ(®)) assessment system for fattening cattle at single measure level, aggregated criterion and principle scores, and overall classification across short-term (1 month) and longer-term periods (6 months). We hypothesized that consistency over time of aggregated criterion and principle scores is higher than that of single measures. Consistency was also expected to be lower with longer intervals between assessments. Data were obtained using the WQ(®) protocol for fattening cattle during three visits (months 0, 1 and 7) on 63 beef farms in Austria, Germany and Italy. Only data from farms where no major changes in housing and management had taken place were considered for analysis. At the single measure level, Spearman rank correlations between visits were >0.7 and variance was lower within farms than between farms for six and two of 19 measures after 1 month and 6 months, respectively. After aggregation of single measures into criterion and principle scores, five and two of 10 criteria and three and one of four principles were found reliable after 1 and 6 months, respectively. At the WQ(®) principle level, this was the case for three and one of four principles. Seventy-nine per cent and 75% of the farms were allocated to the same overall welfare category after 1 month and 6 months. Possible reasons for a lack of consistency are seasonal effects or short-term fluctuations that occur under normal farm conditions, low prevalence of clinical measures and probably insufficient sample size, whereas poor inter-observer agreement leading to inflation of correlation can be ruled out. At the criterion and principle level, aggregation of information into scores appears to partly smoothen undirected variation at the single measure level without losing sensitivity in terms of welfare evaluation. Reliable on-farm animal welfare assessments should therefore be based on repeated assessments. Further long-term studies are recommended to better understand the factors influencing consistency over time. PMID:24330803

  4. LIPID PROFILE OF CIRRHOTIC PATIENTS AND ITS ASSOCIATION WITH PROGNOSTIC SCORES: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Lílian BASSANI

    2015-09-01

    Full Text Available BackgroundIn cirrhosis the production of cholesterol and lipoproteins is altered.ObjectiveEvaluate the lipid profile by measuring total cholesterol, very low-density lipoprotein, low-density lipoprotein, high-density lipoprotein and triglyceride levels in patients with cirrhosis caused by alcoholism and/or hepatitis C virus infection and determine its association with Child-Pugh and MELD scores.MethodsCross-sectional retrospective study of patients treated at the outpatient clinic in Porto Alegre, Brazil, from 2006 to 2010.ResultsIn total, 314 records were reviewed, and 153 (48.7% met the inclusion criteria, of which 82 (53.6% had cirrhosis that was due to hepatitis C virus infection, 50 (32.7% were due to alcoholism, and 21 (13.7% were due to alcoholism and hepatitis C virus infection. The total cholesterol levels diminished with a Child-Pugh progression (P20 was associated with lower total cholesterol levels (<100mg/dL; P<0.001, very low-density lipoprotein (<16 mg/dL; P=0.006, and low-density lipoprotein (<70 mg/dL; P=0.003. Inverse and statistically significant correlations were observed between Child-Pugh and all the lipid fractions analyzed (P<0.001. The increase in MELD was inversely correlated with reduced levels intotal cholesterol (P<0.001, high-density lipoprotein (P<0.001, low-density lipoprotein (P<0.001, very low-density lipoprotein (P=0.030 and triglyceride (P=0.003.ConclusionA reduction in the lipid profile in patients with cirrhosis due to hepatitis C virus infection and/or alcoholism was significantly associated with the Child-Pugh and MELD prognostic markers. These results suggest that the lipid profile may be used as a tool to assist in evaluating liver disease.

  5. On k-hypertournament losing scores

    CERN Document Server

    Pirzada, Shariefuddin

    2010-01-01

    We give a new and short proof of a theorem on k-hypertournament losing scores due to Zhou et al. [G. Zhou, T. Yao, K. Zhang, On score sequences of k-tournaments, European J. Comb., 21, 8 (2000) 993-1000.

  6. Constancy of IQ Scores among Gifted Children.

    Science.gov (United States)

    Cahan, Sorel; Gejman, Alicia

    1993-01-01

    The constancy of intelligence quotients (IQs) of 161 gifted Israeli children, obtained initially in grades K-4 and retested 1-4 years later, was examined. Results indicated that 86% still qualified as gifted on the retest, with mean differences of five to eight IQ points. Performance scores tended to remain constant, whereas verbal scores tended…

  7. Causal Moderation Analysis Using Propensity Score Methods

    Science.gov (United States)

    Dong, Nianbo

    2012-01-01

    This paper is based on previous studies in applying propensity score methods to study multiple treatment variables to examine the causal moderator effect. The propensity score methods will be demonstrated in a case study to examine the causal moderator effect, where the moderators are categorical and continuous variables. Moderation analysis is an…

  8. Bayesian Model Averaging for Propensity Score Analysis

    Science.gov (United States)

    Kaplan, David; Chen, Jianshen

    2013-01-01

    The purpose of this study is to explore Bayesian model averaging in the propensity score context. Previous research on Bayesian propensity score analysis does not take into account model uncertainty. In this regard, an internally consistent Bayesian framework for model building and estimation must also account for model uncertainty. The…

  9. Reliability criteria for voltage stability

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Carson W.; Silverstein, Brian L. [Bonneville Power Administration, Portland, OR (United States)

    1994-12-31

    In face of costs pressures, there is need to allocate scare resources more effectively in order to achieve voltage stability. This naturally leads to development of probabilistic criteria and notions of rick management. In this paper it is presented a discussion about criteria for long term voltage stability limited to the case in which the time frames are topically several minutes. (author) 14 refs., 1 fig.

  10. Overexpression of epidermal growth factor receptor as a prognostic factor in colorectal cancer on the basis of the Allred scoring system

    Directory of Open Access Journals (Sweden)

    Rokita M

    2013-07-01

    Full Text Available Marta Rokita,1 Rafal Stec,1 Lubomir Bodnar,1 Radoslaw Charkiewicz,2 Jan Korniluk,1 Marta Smoter,1 Marzena Cichowicz,3 Lech Chyczewski,4 Jacek Nikli?ski,2 Wojciech Koz?owski,3 Cezary Szczylik11Department of Oncology, Military Institute of Medicine, Central Teaching Hospital, Warsaw, Poland; 2Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland; 3Department of Pathology, Military Institute of the Health Services in Warsaw, Warsaw, Poland; 4Department of Clinical Pathology, Medical University of Bialystok, Bialystok, PolandBackground: Overexpression of epidermal growth factor receptor (EGFR is found in many types of neoplasms. The aim of the study was to evaluate EGFR expression in colorectal cancer (CRC specimens and to determine whether EGFR expression correlates with clinicopathological data and overall survival.Patients and methods: Tissue specimens from 181 consecutive CRC patients treated at the Military Institute of Medicine in 2006–2010 were collected and examined for EGFR expression, by immunohistochemistry staining. The staining intensity and percentage of cells with membranous EGFR expression were scored and then grouped according to the parameters of the Allred Scoring system. Cutoff values were subjected to further statistical analysis. Univariate tests and a multivariate Cox proportional hazards model were used in data analysis.Results: EGFR was overexpressed in 96 of 181 CRC specimens (53%. EGFR expression was not correlated with other clinicopathological variables. On univariate analysis, overexpression of EGFR, determined by PS (percentage score (>3 and total score (sum of PS and intensity score (>4, was associated with poor overall survival. On multivariate analysis, EGFR overexpression (PS > 3 was an independent adverse prognostic factor (hazard ratio [HR] 1.62; 95% confidence interval [CI]: 1.03–2.53. Elevated carcinoembryonic antigen (CEA serum concentration before treatment, performance status (Word Health Organization [WHO]-2, and tumor localized in colon and liver metastases were also independent unfavorable prognostic factors.Conclusion: EGFR overexpression (PS > 3 in a CRC patient population was an independent adverse prognostic factor. Implementation of the Allred Scoring system criteria into clinical practice might facilitate treatment decisions in CRC patients.Keywords: expression, receptor, prognosis, cancer

  11. An assessment of the test–retest reliability of the New Nordic Diet score

    Directory of Open Access Journals (Sweden)

    Helga Birgit Bjørnarå

    2015-08-01

    Full Text Available Background: There is a growing interest in the New Nordic Diet (NND as a potentially health promoting, environmentally friendly, and palatable regional diet. Also, dietary scores are gaining ground as a complementary approach for examining relations between dietary patterns and various health outcomes. A score assessing adherence to the NND has earlier been published, yet not tested for reliability. Objective: To assess the test–retest reliability of the NND score in a sample of parents of toddlers, residing in Southern Norway. Design: A questionnaire survey was completed on two occasions, approximately 14 days apart, by 67 parents of toddlers [85% females, mean age 34 years (SD=5.3 years]. The NND score was constructed from 24 items and comprised 10 subscales that summarize meal pattern and intake of typical Nordic foods. Each subscale was dichotomized by the median and assigned values of ‘0’ or ‘1’. Adding the subscales yielded a score ranging from 0 to 10, which was further trichotomized. Test–retest reliability of the final NND score and individual subscales was assessed by Pearson's correlation coefficient and Spearman's rank correlation coefficient, respectively. Additionally, cross tabulation and kappa measure of agreement (k were used to assess the test–retest agreement of classification into the NND score, and the subscales. Results: Test–retest correlations of the NND score and subscales were r=0.80 (Pearson and r=0.54–0.84 (Spearman, respectively, all p<0.001. There were 69% (k=0.52 and 67–88% (k=0.32–0.76 test–retest correct classification of the trichotomized score and the dichotomized subscales, respectively. Conclusion: The NND score and the 10 subscales appear to have acceptable test–retest reliability when tested in a sample of parents of toddlers.

  12. Zertifikat Deutsch als Fremdsprache and the Oral Proficiency Interview: A Comparison of Test Scores and Examinations.

    Science.gov (United States)

    Lalande, John F.; Schweckendiek, Jurgen

    1986-01-01

    Investigates what correlations might exist between an individual's score on the Zertifikat Deutsch als Fremdsprache and on the Oral Proficiency Interview. The tests themselves are briefly described. Results indicate that the two tests appear to correlate well in their evaluation of speaking skills. (SED)

  13. Generalized Fisher Score for Feature Selection

    CERN Document Server

    Gu, Quanquan; Han, Jiawei

    2012-01-01

    Fisher score is one of the most widely used supervised feature selection methods. However, it selects each feature independently according to their scores under the Fisher criterion, which leads to a suboptimal subset of features. In this paper, we present a generalized Fisher score to jointly select features. It aims at finding an subset of features, which maximize the lower bound of traditional Fisher score. The resulting feature selection problem is a mixed integer programming, which can be reformulated as a quadratically constrained linear programming (QCLP). It is solved by cutting plane algorithm, in each iteration of which a multiple kernel learning problem is solved alternatively by multivariate ridge regression and projected gradient descent. Experiments on benchmark data sets indicate that the proposed method outperforms Fisher score as well as many other state-of-the-art feature selection methods.

  14. Z Score Estimation for Indian Banking Sector

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    Roli Pradhan

    2014-12-01

    Full Text Available From traditional times the Z score values have been constantly used for prediction of Bankruptcy. This has been vital to both the lenders and investors whose returns are based on solvency estimates. The terms of credit have gone a U turn from the traditional times to the modern scenario today. The basic concern of prediction is to evaluate the terms of credit and ensure repayment safely. Z score has been used as a tool to evaluate the credibility of the firms. This paper provides the Z score value for the public sector banks. This value is useful when these banks demand loans from the RBI or any other funding agency. The usage of back propagation neural network is to forecast the internal parameters of Z score and then use these internal parameters to forecast the Z score value up to 2020. Thus the paper emphasizes the usage of BPNN for prediction of bankruptcy for public sector banks in India.

  15. Exploiting Uncertain and Temporal Information in Correlation

    OpenAIRE

    Bigham, John

    2013-01-01

    A modelling language is described which is suitable for the correlation of information when the underlying functional model of the system is incomplete or uncertain and the temporal dependencies are imprecise. An efficient and incremental implementation is outlined which depends on cost functions satisfying certain criteria. Possibilistic logic and probability theory (as it is used in the applications targetted) satisfy these criteria.

  16. Potentially inappropriate prescribing in institutionalised older patients in Spain: the STOPP-START criteria compared with the Beers criteria

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    Bonet M

    2012-06-01

    Full Text Available Objective: The aims of this study were to identify potentially inappropriate prescribing using the Beers and STOPP criteria. The START criteria were applied to detect prescription omission in the geriatric population. We compared the utility of these criteria in institutionalised older people.Methods: Descriptive study reviewing the medication and clinical records of 81 residents (aged 65 years and more by pharmacists in a nursing home in the Lleida region (Spain.Results: The mean patients’ age was 84 (SD=8 years, with an average of 5 drugs per resident (total prescriptions: 416 medicines. The Beers criteria identified potentially inappropriate medication use in 25% of patients and 48% of patients used at least 1 inappropriate medication according to STOPP criteria. The most frequent potentially inappropriate medications for both criteria were long-acting benzodiazepines and NSAIDs. START detected 58 potential prescribing omissions in 44% of patients. Calcium-vitamin D supplementation in osteoporosis was the most frequent rule (15%, but omissions corresponding to the cardiovascular system implied 23% of patients.Conclusion: The STOPP-START criteria reveal that potentially inappropriate prescribing (PIP is a highly prevalent problem among Spanish nursing home residents, and a statistically significant positive correlation was found between the number of medicines prescribed and the number of PIP detected in this study. The STOPP criteria detect a larger number of PI medications in this geriatric population than the Beers criteria. The prescribing omissions detected by the START criteria are relevant and require intervention. Pharmacists’ review of medications may help identify potentially inappropriate prescribing and, through an interdisciplinary approach, working with physicians may improve prescribing practices among geriatric residents of nursing homes.

  17. Potentially inappropriate prescribing in institutionalised older patients in Spain: the STOPP-START criteria compared with the Beers criteria

    Science.gov (United States)

    Ubeda, Amalia; Ferrándiz, Luisa; Maicas, Nuria; Gomez, Cristina; Bonet, Montserrat; Peris, Jose E.

    Objective The aims of this study were to identify potentially inappropriate prescribing using the Beers and STOPP criteria. The START criteria were applied to detect prescription omission in the geriatric population. We compared the utility of these criteria in institutionalised older people. Methods Descriptive study reviewing the medication and clinical records of 81 residents (aged 65 years and more) by pharmacists in a nursing home in the Lleida region (Spain). Results The mean patients’'age was 84 (SD=8) years, with an average of 5 drugs per resident (total prescriptions: 416 medicines). The Beers criteria identified potentially inappropriate medication use in 25% of patients and 48% of patients used at least 1 inappropriate medication according to STOPP criteria. The most frequent potentially inappropriate medications for both criteria were long-acting benzodiazepines and NSAIDs. START detected 58 potential prescribing omissions in 44% of patients. Calcium-vitamin D supplementation in osteoporosis was the most frequent rule (15%), but omissions corresponding to the cardiovascular system implied 23% of patients. Conclusions The STOPP-START criteria reveal that potentially inappropriate prescribing (PIP) is a highly prevalent problem among Spanish nursing home residents, and a statistically significant positive correlation was found between the number of medicines prescribed and the number of PIP detected in this study. The STOPP criteria detect a larger number of PI medications in this geriatric population than the Beers criteria. The prescribing omissions detected by the START criteria are relevant and require intervention. Pharmacists’ review of medications may help identify potentially inappropriate prescribing and, through an interdisciplinary approach, working with physicians may improve prescribing practices among geriatric residents of nursing homes. PMID:24155822

  18. Low amniotic fluid index in high risk pregnancy and poor apgar score at birth

    International Nuclear Information System (INIS)

    To determine the accuracy of antepartum Amniotic Fluid Index (AFI) of 5 cm was labeled as predictor of good outcome at birth. The subjects in both the groups were demographically matched and fulfilled the inclusion and exclusion criteria. The Apgar score was calculated at 5 minutes of birth. The newborns, with Apgar score 6 were labeled as healthy. AFI was compared with Apgar score, using Chi-square and a p-value was calculated to determine the statistical significance. Sensitivity, specificity, efficiency and the predictive values of AFI at a cut off point of < 5 cm as a predictor of adverse outcome at birth (Apgar score of < 6 at 5 minutes of birth) in high-risk pregnancy were calculated. Only 8 neonates of 50 women with low AFI had low Apgar score. Similarly, 6 neonates of 50 women with normal AFI had poor Apgar score. The diagnostic sensitivity, specificity, positive predictive value, negative predictive value and efficiency of AFI as test were 57.1%, 51.3%, 16%, 88% and 52% respectively. Low AFI is a poor predictor of adverse outcome for high-risk term patients. AFI is not a good screening test for high-risk pregnant women at term for birth of an infant with low Apgar score. (author)

  19. Sex and STEM Occupation Predict Autism-Spectrum Quotient (AQ) Scores in Half a Million People.

    Science.gov (United States)

    Ruzich, Emily; Allison, Carrie; Chakrabarti, Bhismadev; Smith, Paula; Musto, Henry; Ring, Howard; Baron-Cohen, Simon

    2015-01-01

    This study assesses Autism-Spectrum Quotient (AQ) scores in a 'big data' sample collected through the UK Channel 4 television website, following the broadcasting of a medical education program. We examine correlations between the AQ and age, sex, occupation, and UK geographic region in 450,394 individuals. We predicted that age and geography would not be correlated with AQ, whilst sex and occupation would have a correlation. Mean AQ for the total sample score was m = 19.83 (SD = 8.71), slightly higher than a previous systematic review of 6,900 individuals in a non-clinical sample (mean of means = 16.94) This likely reflects that this big-data sample includes individuals with autism who in the systematic review score much higher (mean of means = 35.19). As predicted, sex and occupation differences were observed: on average, males (m = 21.55, SD = 8.82) scored higher than females (m = 18.95; SD = 8.52), and individuals working in a STEM career (m = 21.92, SD = 8.92) scored higher than individuals non-STEM careers (m = 18.92, SD = 8.48). Also as predicted, age and geographic region were not meaningfully correlated with AQ. These results support previous findings relating to sex and STEM careers in the largest set of individuals for which AQ scores have been reported and suggest the AQ is a useful self-report measure of autistic traits. PMID:26488477

  20. CLINICAL, NEUROPSYCHOLOGICAL AND NEUROPHYSIOLOGICAL CORRELATES OF DRUG RESISTANT JUVENILE MYOCLONIC EPILEPSY

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    Davis

    2015-09-01

    Full Text Available This study was designed to find the clinical, neuropsychologic, EEG and TMS (Transcranial Magnetic Stimulation characteristics of patients with treatment resistant Juvenile Myoclonic Epilepsy (JME. JME diagnosis was according to the criteria defined by Classification and Terminology Commission of the International League Against Epilepsy. For the purpose of this study, ‘treatment resistance’ was defined as having two or more generalized tonic - clonic sei zures (GTCS or disabling myoclonus resulting in falls, while on o