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Summary of the criteria and scoring scheme adopted by the ...  

disease/issue considered, a score for the risk and impact on each of four 'reasons \\for intervention' ... The prototype DST has been built using Microsoft Excel. 2. Key \\criteria that ..... introduced, for exotics) on the environment to take account of ...

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Examining Classification Criteria: A Comparison of Three Cut Score Methods  

Science.gov (United States)

This study compared 3 different methods of creating cut scores for a screening instrument, T scores, receiver operating characteristic curve (ROC) analysis, and the Rasch rating scale method (RSM), for use with the Behavioral and Emotional Screening System (BESS) Teacher Rating Scale for Children and Adolescents (Kamphaus & Reynolds, 2007). Using…

DiStefano, Christine; Morgan, Grant

2011-01-01

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Defining the nociceptive flexion reflex (NFR) threshold in human participants: A comparison of different scoring criteria  

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Despite the widespread use of the nociceptive flexion reflex (NFR) paradigm in clinical and experimental pain research, there is currently no consensus on how best to define NFR threshold. Accordingly, the present studies were designed to assess the accuracy and reliability of different NFR threshold scoring criteria. Study 1 compared 13 scoring criteria in their accuracy for identifying the presence of the NFR, then generated empirically derived cut-points for the best criteria, and examined...

2007-01-01

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The Correlation Between GRE Scores and Performance in Graduate School  

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We investigate the correlation between GRE scores and various measures of performance for graduate students in the Physics Department at Harvard University. We consider students who entered the program between 1980 and 1989. The degree to which GRE scores can predict performance is shown for different subgroups of students.

Morin, David

1996-05-01

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The relationship between the ability to identify evaluation criteria and integrity test scores  

Directory of Open Access Journals (Sweden)

Full Text Available It has been argued that applicants who have the ability to identify what kind of behavior is evaluated positively in a personnel selection situation can use this information to adapt their behavior accordingly. Although this idea has been tested for assessment centers and structured interviews, it has not been studied with regard to integrity tests (or other personality tests. Therefore, this study tested whether candidates’ ability to identify evaluation criteria (ATIC correlates with their integrity test scores. Candidates were tested in an application training setting (N = 92. The results supported the idea that ATIC also plays an important role for integrity tests. New directions for future research are suggested based on this finding.

CORNELIUS J. KÖNIG

2006-09-01

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Criteria for genuine multiparticle quantum correlations  

International Nuclear Information System (INIS)

This thesis is devoted to different aspects of the detection and characterization of quantum correlations in multiparticle systems. These include the statistical verification of non-locality and entanglement in experiments, a versatile approach for the detection of genuine multipartite entanglement that will be applied to different classes of states and the characterization of entanglement using a multipartite hidden-variable theory. We start by investigating statistical effects on the confidence with which one can ensure that a multipartite state is non-local and therefore entangled. It turns out that for the standard photonic error model, the statistical significance of a non-locality test with comparably low violation, the so-called Mermin inequality, can exceed the significance of a test with high violation, namely of the Ardehali inequality. We also report about an experiment with four photons that verifies this behavior. Moreover, we also find that the range of white noise in which the Mermin inequality achieves a higher statistical significance grows exponentially with an increasing number of particles. Then, we pass on to the detection of genuine multipartite entanglement given the density matrix of a state. Using supersets of the sets of separable states, we introduce a criterion for genuine multipartite entanglement that can be implemented as a semidefinite program and test its performance on several example cases. Furthermore, this criterion naturally leads to an entanglement monotone that generalizes the bipartite negativity. Subsequently, the criterion is applied to the class of graph states. In this way, we obtain analytical construction methods for entanglement criteria, so-called entanglement witnesses, for many different graph states and an arbitrary number of qubits. These witnesses turn out to be strong, as their white noise tolerance converges to the maximum possible value, namely one, for a growing number of qubits. At the same time, the additional experimental effort in terms of settings to be measured, stays constant. Furthermore, as the criterion performs so well on graph states, we consider the question whether it can provide necessary and sufficient criteria for entanglement. We show that this is indeed the case for some special graph-diagonal states. In addition, our line of argument also provides deeper insights into the properties of our criterion and methods to construct biseparable graph-diagonal states. Finally, we turn to the characterization of quantum mechanical correlations given by the bipartite non-local model introduced by A. Leggett. We present different ways of extending this model to the case of many particles and also derive an inequality that shows the imcompatibility of such multipartite Leggett models with quantum mechanics. (author)

2012-01-01

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Analysis of four scoring systems and monocentric experience to optimize criteria for marginal kidneytransplantation.  

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There is a strong need among the transplantation community to identify common criteria to utilize the pool of expanded criteria donors (ECD), considering the disparity between organ demand and supply as well as the benefits of transplantation on long-term mortality compared with survival on dialysis, also in patients transplanted with these organs. The purpose of this article was to analyze scoring systems proposed in literature by Nyberg, Anglicheau, Rao (Kidney Donor Risk Index), and Schold...

Segoloni, Giuseppe; Gallo, Ester; Tamagnone, Michela; Fop, Fabrizio

2010-01-01

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Automatic sleep scoring in normals and in individuals with neurodegenerative disorders according to new international sleep scoring criteria  

DEFF Research Database (Denmark)

The aim of this study was to develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine. A biomedical signal processing algorithm was developed, allowing for automatic sleep depth quantification of routine polysomnographic recordings through feature extraction, supervised probabilistic Bayesian classification, and heuristic rule-based smoothing. The performance of the algorithm was tested using 28 manually classified day-night polysomnograms from 18 normal subjects and 10 patients with Parkinson disease or multiple system atrophy. This led to quantification of automatic versus manual epoch-by-epoch agreement rates for both normals and abnormals. Resulting average agreement rates were 87.7% (Cohen's Kappa: 0.79) and 68.2% (Cohen's Kappa: 0.26) in the normal and abnormal group, respectively. Based on an observed reliability of the manual scorer of 92.5% (Cohen's Kappa: 0.87) in the normal group and 85.3% (Cohen's Kappa: 0.73) in the abnormal group, this study concluded that although the developed algorithm was capable of scoring normal sleep with an accuracy around the manual interscorer reliability, it failed in accurately scoring abnormal sleep as encountered for the Parkinson disease/multiple system atrophy patients.

Jensen, Peter S; Sorensen, Helge B D

2010-01-01

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Automatic Sleep Scoring in Normals and in Individuals with Neurodegenerative Disorders According to New International Sleep Scoring Criteria  

DEFF Research Database (Denmark)

The aim of this study was to develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine. A biomedical signal processing algorithm was developed, allowing for automatic sleep depth quantification of routine polysomnographic recordings through feature extraction, supervised probabilistic Bayesian classification, and heuristic rule-based smoothing. The performance of the algorithm was tested using 28 manually classified day-night polysomnograms from 18 normal subjects and 10 patients with Parkinson disease or multiple system atrophy. This led to quantification of automatic versus manual epoch-by-epoch agreement rates for both normals and abnormals. Resulting average agreement rates were 87.7% (Cohen's Kappa: 0.79) and 68.2% (Cohen's Kappa: 0.26) in the normal and abnormal group, respectively. Based on an observed reliability of the manual scorer of 92.5% (Cohen's Kappa: 0.87) in the normal group and 85.3% (Cohen's Kappa: 0.73) in the abnormal group, this study concluded that although the developed algorithm was capable of scoring normal sleep with an accuracy around the manual interscorer reliability, it failed in accurately scoring abnormal sleep as encountered for the Parkinson disease/multiple system atrophy patients.

Jensen, Peter S.; Sørensen, Helge Bjarup Dissing

2010-01-01

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Investigator feedback about the 2005 NIH diagnostic and scoring criteria for chronic GVHD.  

Science.gov (United States)

The 2005 National Institutes of Health (NIH) consensus criteria for chronic GVHD have set standards for reporting. Many questions, however, have arisen regarding their implementation and utilization. To identify perceived areas of controversy, we conducted an international survey on diagnosis and scoring of chronic GVHD. Agreement was observed for 50-83% of the 72 questions in 7 topic areas. There was agreement on the need for modifying criteria in six situations: two or more distinctive manifestations should be enough to diagnose chronic GVHD; symptoms that are not due to chronic GVHD should be scored differently; active disease and fixed deficits should be distinguished; a minimum threshold body surface area of hidebound skin involvement should be required for a skin score of 3; asymptomatic oral lichenoid changes should be considered a score 1; and lung biopsy should be unnecessary to diagnose chronic GVHD in a patient with bronchiolitis obliterans as the only manifestation. The survey also identified 26 points of controversy. Whenever possible, studies should be conducted to confirm the appropriateness of any revisions. In cases where data are not available, clarification of the NIH recommendations by consensus is necessary. This survey should inform future research in the field and revisions of the current consensus criteria. PMID:24464142

Inamoto, Y; Jagasia, M; Wood, W A; Pidala, J; Palmer, J; Khera, N; Weisdorf, D; Carpenter, P A; Flowers, M E D; Jacobsohn, D; Martin, P J; Lee, S J; Pavletic, S Z

2014-04-01

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Estimates of genetic parameters for visual scores and their correlation with production and reproductive traits in Brahman cattle  

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Full Text Available The objective of this study was to evaluate the association of visual scores of body structure, precocity and muscularity with production (body weight at 18 months and average daily gain and reproductive (scrotal circumference traits in Brahman cattle in order to determine the possible use of these scores as selection criteria to improve carcass quality. Covariance components were estimated by the restricted maximum likelihood method using an animal model that included contemporary group as fixed effect. A total of 1,116 observations of body structure, precocity and muscularity were used. Heritability was 0.39, 043 and 0.40 for body structure, precocity and muscularity, respectively. The genetic correlations were 0.79 between body structure and precocity, 0.87 between body structure and muscularity, and 0.91 between precocity and muscularity. The genetic correlations between visual scores and body weight at 18 months were positive (0.77, 0.57 and 0.59 for body structure, precocity and muscularity, respectively. Similar genetic correlations were observed between average daily gain and visual scores (0.60, 0.57 and 0.48, respectively, whereas the genetic correlations between scrotal circumference and these scores were low (0.13, 0.02, and 0.13. The results indicate that visual scores can be used as selection criteria in Brahman breeding programs. Favorable correlated responses should be seen in average daily gain and body weight at 18 months. However, no correlated response is expected for scrotal circumference.

Tássia Souza Bertipaglia

2012-06-01

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Nottingham-defined mitotic score: comparison with visual and image cytometric phosphohistone H3 labeling indices and correlation with Oncotype DX recurrence score.  

Science.gov (United States)

Prognosis of breast cancer patients has been determined traditionally by lymph node status, tumor size, and histologic grade. In recent years the Oncotype DX recurrence score (RS) assay has emerged as an expensive adjunct prognostic tool. Markers of proliferation play a large role in determination of RS, and we have shown previously that immunohistochemical expression of proliferation markers Ki-67 and phosphohistone H3 (PPH3) correlates with RS. Our current goal is comparison of the hematoxylin and eosin (H&E) mitotic score, defined by the Nottingham grading system, with anti-PPH3 mitotic figure labeling assessed by both visual and automated image analysis and correlation of mitotic score results with RS. Estrogen receptor-positive breast carcinomas from 137 patients with Oncotype DX testing were selected. A representative H&E-stained tumor section was evaluated. Mitoses were counted per 10 high-power fields and tumors graded using the Nottingham criteria by 1 pathologist in accordance with College of American Pathologists-recommended mitotic count cutoffs for a field diameter of 0.55 mm. An additional section was immunostained with PPH3 antibody. PPH3 mitotic scores were determined visually and by automated imaging system. Statistical analysis was performed using univariate tests and Spearman coefficient. There was a statistically significant positive correlation among the 3 methods of mitotic score assessment. Specifically, correlation of tumor grades obtained using visual and automated methods of assessment of mitotic activity with PPH3 stain was the strongest and most statistically significant (weighted ? value 0.84, Pcoefficient 0.89, Ppositive correlation between H&E mitosis score and RS (Pcoefficient 0.30) and between visual PPH3 mitotic score and RS (Pcoefficient 0.28). In conclusion, mitotic score by any of the 3 methods studied may be useful in assessing tumor grade, proliferation, and prognosis. PMID:22495373

Zbytek, Blazej; Cohen, Cynthia; Wang, Jason; Page, Andrew; Williams, Daron J; Adams, Amy L

2013-01-01

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Diagnostic accuracy of modified kenneth jones scoring criteria (mkjsc) in confirmed cases of tuberculosis in children  

International Nuclear Information System (INIS)

Background: Tuberculosis (TB) is a granulomatous disease caused by Mycobacterium tuberculosis. The gold standard for the diagnosis of tuberculosis is detection of Mycobacterium tubercle bacilli. However, clinical scoring systems are most widely used for the diagnosis of TB in children. Objective: To determine the diagnostic accuracy of modified Kenneth Jones scoring criteria (MKJSC) in conformed cases of tuberculosis. Methodology: This cross-sectional comparative study was conducted in the department of Paediatrics, King Edward Medical University / Mayo Hospital, Lahore from January to June 2007. One hundred children below 15 years of age were enrolled. They were diagnosed as suspected cases of TB on the basis of fever and cough for more than 15 days. MKJSC was applied and each child was subjected to confirmatory test for TB. Results: There was an overall male preponderance of 54%. The mean age of study population was 1.8 +- 0.7 years. Out of 100 children, 66% were diagnosed as TB cases (23 with confirmatory tests and 43 with MKJSC of 5 or more). Sensitivity, specificity, positive and negative predictive value of MKJSC was 73.91%, 44.16%, 28.33%, and 85% respectively. Diagnostic accuracy of MKJSC was 51%. Conclusion: Present study does not support the hypothesis that MKJSC is a good alternative to confirmatory tests to diagnose tuberculosis in children. However, MKJSC is a simple tool, which can be applied to improve the case detection rate in the absence of sophisticated tests. (author)

2013-01-01

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Estimates of genetic parameters for visual scores and their correlation with production and reproductive traits in Brahman cattle  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The objective of this study was to evaluate the association of visual scores of body structure, precocity and muscularity with production (body weight at 18 months and average daily gain) and reproductive (scrotal circumference) traits in Brahman cattle in order to determine the possible use of thes [...] e scores as selection criteria to improve carcass quality. Covariance components were estimated by the restricted maximum likelihood method using an animal model that included contemporary group as fixed effect. A total of 1,116 observations of body structure, precocity and muscularity were used. Heritability was 0.39, 043 and 0.40 for body structure, precocity and muscularity, respectively. The genetic correlations were 0.79 between body structure and precocity, 0.87 between body structure and muscularity, and 0.91 between precocity and muscularity. The genetic correlations between visual scores and body weight at 18 months were positive (0.77, 0.57 and 0.59 for body structure, precocity and muscularity, respectively). Similar genetic correlations were observed between average daily gain and visual scores (0.60, 0.57 and 0.48, respectively), whereas the genetic correlations between scrotal circumference and these scores were low (0.13, 0.02, and 0.13). The results indicate that visual scores can be used as selection criteria in Brahman breeding programs. Favorable correlated responses should be seen in average daily gain and body weight at 18 months. However, no correlated response is expected for scrotal circumference.

Bertipaglia, Tássia Souza; Carreño, Luis Orlando Duitama; Machado, Carlos Henrique Cavallini; Andrighetto, Cristiana; Fonseca, Ricardo da.

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Correlation of the score for subjective pain with physical disability, clinical and radiographic scores in recent onset rheumatoid arthritis  

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Full Text Available Abstract Background To analyse the relationship between subjective pain score and other measures of clinical, radiographic and functional status; in particular Larsen radiographic scores and Health Assessment Questionnaire (HAQ; in patients with severe rheumatoid arthritis (RA with a disease duration of less than 3 years. Methods In this cross sectional study of 105 patients with RA (76 women, 29 men: mean age 50.93; mean disease duration 15.86 months; 71% rheumatoid factor positive subjective pain was assessed according to the Visual Analog Scale (VAS. Correlation coefficients between pain score and disease activity measures (patients' global assessment of disease by VAS, number of tender and swollen joints, morning stiffness, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP] and titre of rheumatoid factor, radiographic evaluations (Larsen-Dale scores for radiographic damage of the small joints of the hands, wrist and feet, disability measures (health assessment questionnaire [HAQ], and demographic variables were calculated; hierarchical regression analysis was done with subjective pain score as the dependent variable. Results The Spearman's correlation coefficient comparing subjective pain and HAQ was 0.421 (p 0.05. In regression analysis, global assessment of disease by patients explained 32.8% of the variation in pain intensity score, morning stiffness 10.7%, CRP 4.0%, HAQ 3.8% and Larsen-Dale scores explained 2.1%; other variables were not significant in the model. Conclusions Pain scores of patients with early severe rheumatoid arthritis are correlated at higher levels with patients' global assessment of disease and with morning stiffness rather than with radiographic or other clinical variables such as number of tender and swollen joints.

Turiel Maurizio

2002-07-01

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Correlation of admissions criteria with academic performance in dental students.  

Science.gov (United States)

Our purpose was to compare admissions criteria as predictors of dental school performance in underachieving and normally tracking dental students. Underachieving dental students were identified by selecting ten students with the lowest class grade point average following the first year of dental school from five classes, resulting in a pool of fifty students. Normally tracking students served as a control and were randomly selected from students who had completed their first year of dental school not in the underachieving group. Admission measures of college grade point average (GPA), science grade point average (SGPA), academic average (AA), Perceptual Ability Test (PAT), college rigor, and academic load in college were evaluated with descriptive statistics, correlation, and regression analysis with first-year and graduating GPA as the dependent variables. Admissions criteria were generally weak predictors of first-year and graduating GPA. However, first-year dental school GPA was a strong predictor (R(2)=0.77) of graduating GPA for normally tracking students and a moderate predictor (R(2)=0.58) for underachieving students. Students who completed the first year of dental school having a low GPA tended to graduate with a low GPA. Therefore, remediation and monitoring would be important during the dental school experience for these students. PMID:17923709

Curtis, Donald A; Lind, Samuel L; Plesh, Octavia; Finzen, Frederick C

2007-10-01

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HRCT score in bronchiectasis: Correlation with pulmonary function tests and pulmonary artery pressure  

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Full Text Available Background: High resolution CT scan (HRCT and its score have an important role in delineating pathological changes and pulmonary functional impairment in patients with bronchiectasis. Aims: To assess pulmonary function tests (PFTs in patients with cystic and cylindrical bronchiectasis. To correlate HRCT score with PFTs and systolic pulmonary artery pressure (SPAP in both radiological types. Materials and Methods: A cross-sectional study of patients with bronchiectasis diagnosed by HRCT was conducted at King Khalid University Hospital, Riyadh, Saudi Arabia. PFTs, HRCT score and SPAP were measured in both types. Results: We studied 94 patients with bronchiectasis: 62 were cystic and 32 were cylindrical. Their mean age was 53.4±17.5 SD years. Forced vital capacity (FVC % and forced expiratory volume in 1 second (FEV1% were significantly lower in cystic patients ( P < .0001 compared with cylindrical and Diffusion capacity (DLCO % was also significantly lower ( p < 0.01. In cystic group PaO2 was significantly lower and PaCO2 higher ( P < 0.0001. HRCT score was correlated with FEV1% (r= -0.51. HRCT score was significantly lower in the cystic group ( P =0.002and correlated with SPAP ( r =0.23. Global HTCT score of 10.3±2.5 was associated with SPAP ?40mmHg( P =0.011. Conclusion: Patients with cystic bronchiectasis have significant impairment of pulmonary physiology compared with cylindrical bronchiectasis patients. HRCT score correlated with PFTs and SPAP.

Alzeer Abdulaziz

2008-01-01

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High resolution CT in children with cystic fibrosis: correlation with pulmonary functions and radiographic scores  

International Nuclear Information System (INIS)

Objective: To compare the high resolution CT (HRCT) scores of the Bhalla system with pulmonary function tests and radiographic and clinical points of the Shwachman-Kulczycki clinical scoring system. Methods: HRCT of the chest was obtained in 40 children to assess the role of HRCT in evaluating bronchopulmonary pathology in children with cystic fibrosis (CF). The HRCT severity scores of the Bhalla system were compared with chest radiographic and clinical points of the Shwachman-Kulczycki scoring system and pulmonary function tests. Only 14 of the patients older than 6 years cooperated with spirometry. Results: HRCT scores correlated well with radiographic points (r=0.80, P1 (r=0.66, P=0.01). Although radiographic points correlated significantly with FVC (r=0.61, P=0.02) and FEV1 (r=0.56, P=0.04), HRCT provides a more precise scoring than the chest X-ray. Conclusion: The HRCT scoring system may provide a sensitive method of monitoring pulmonary disease status and may replace the radiographic scoring in the Shwachman-Kulczycki system. It may be helpful especially in follow-up of small children too young to cooperate with spirometry

2001-01-01

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Correlation between the FINish diabetes risk score and the severity of coronary artery disease  

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Full Text Available Background/Aim. The FINish Diabetes RIsk SCore (FINDRISC which includes age, body mass index (BMI, waist circumference, physical (in activity, diet, arterial hypertension, history of high glucose levels, and family history of diabetes, is of a great significance in identifying patients with impaired glucose tolerance and a 10-year risk assessment of developing type 2 diabetes in adults. Due to the fact that the FINDRISC score includes parameters which are risk factors for coronary artery disease (CAD, our aim was to determine a correlation between this score, and some of its parameters respectively, with the severity of angiographically verified CAD in patients with stable angina in two ways: according to the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX score and the number of diseased coronary arteries. Methods. The study included 70 patients with stable angina consecutively admitted to the Clinic of Cardiology, Military Medical Academy, Belgrade. The FINDRISC score was calculated in all the patients immediately prior to angiography. Venous blood samples were collected and inflammatory markers [erythrocyte sedimentation rate (ESR, leucocytes, C-reactive protein (CRP, total cholesterol, HDL cholesterol, triglycerides and fasting glucose] determined. Coronary angiography was performed in order to determine the severity of coronary artery disease according to the SYNTAX score and the number of affected coronary vessels: 1-vessel, 2-vessel or 3-vessel disease (hemodynamically significant stenoses: more than 70% of the blood vessel lumen. The patients were divided into three groups regarding the FINDRISC score: group I: 5-11 points; group II: 12-16 points; group III: 17-22 points. Results. Out of 70 patients (52 men and 18 women enrolled in this study, 14 had normal coronary angiogram. There was a statistically significant positive correlation between the FINDRISC score and its parameters respectively (age, body mass index-BMI, waist circumference and the severity of CAD according to the SYNTAX score (p < 0.001 and the number of diseased coronary arteries (p < 0.001. The patients with higher FINDRISC score (groups II and III had more severe and extensive CAD according to the SYNTAX score than the group I. The odds ratio with 95% confidence intervals (CI between the group III and the group I was 5.143 (95% CI 1.299-20.360, p = 0.002 and between the group II and the group I 5.867 (95% CI 1.590- 21.525, p = 0.007. There were no differences in odds ratio for multivessel disease according to FINDRISC score between the group II and the group III [1.141; (95% CI 0.348-3.734. In the group I mean SYNTAX score was 5.18, and more than 70% of patients had normal coronary angiogram. In the group II mean SYNTAX score was 17.06, and more than 70% of patients had 2-vessel disease and 3- vessel disease, and in the group III mean SYNTAX score was 18.89, and 2-vessel and 3-vessel disease had 36.36% and 31.82% patients, respectively. In multiple regression analysis, where SYNTAX score was dependent variable, and age, BMI, waist circumference, FINDRISC score were independent variables, we found that only FINDRISC score was independent predictor of SYNTAX score. Conclusion. The obtained results suggest a statistically significant correlation between the FINDRISC score and its parameters (age, BMI, waist circumference and the severity of CAD according to the SYNTAX score and the number of diseased coronary arteries. The FINDRISC score may be useful in identifying patients at the high risk for coronary artery disease.

?uri? Predrag

2014-01-01

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Correlated physical and mental health summary scores for the SF-36 and SF-12 Health Survey, V.1  

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Full Text Available Abstract Background The SF-36 and SF-12 summary scores were derived using an uncorrelated (orthogonal factor solution. We estimate SF-36 and SF-12 summary scores using a correlated (oblique physical and mental health factor model. Methods We administered the SF-36 to 7,093 patients who received medical care from an independent association of 48 physician groups in the western United States. Correlated physical health (PCSc and mental health (MCSc scores were constructed by multiplying each SF-36 scale z-score by its respective scoring coefficient from the obliquely rotated two factor solution. PCSc-12 and MCSc-12 scores were estimated using an approach similar to the one used to derive the original SF-12 summary scores. Results The estimated correlation between SF-36 PCSc and MCSc scores was 0.62. There were far fewer negative factor scoring coefficients for the oblique factor solution compared to the factor scoring coefficients produced by the standard orthogonal factor solution. Similar results were found for PCSc-12, and MCSc-12 summary scores. Conclusion Correlated physical and mental health summary scores for the SF-36 and SF-12 derived from an obliquely rotated factor solution should be used along with the uncorrelated summary scores. The new scoring algorithm can reduce inconsistent results between the SF-36 scale scores and physical and mental health summary scores reported in some prior studies. (Subscripts C = correlated and UC = uncorrelated

Cunningham William E

2007-09-01

 
 
 
 
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Searching for Epistasis and Linkage Heterogeneity by Correlations of Pedigree-Specific Linkage Scores  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Recognizing that multiple genes are likely responsible for common complex traits, statistical methods are needed to rapidly screen for either interacting genes or locus heterogeneity in genetic linkage data. To achieve this, some investigators have proposed examining the correlation of pedigree linkage scores between pairs of chromosomal regions, because large positive correlations suggest interacting loci and large negative correlations suggest locus heterogeneity (Cox et al. [1999]; Maclean...

Schaid, Daniel J.; Mcdonnell, Shannon K.; Carlson, Erin E.; Thibodeau, Stephen N.; Stanford, Janet L.; Ostrander, Elaine A.

2008-01-01

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Correlations in a Mozart's music score (K-73x) with palindromic and upside-down structure  

Science.gov (United States)

In this work, we study long-range correlations in a “Scherzo-Duetto di Mozart” score (K-73x) for two violins. This is a fascinating piece, as the second violin part is upside down on the same sheet below the first violin, and some parts are like a palindrome. Given such ingenious structure, it is expected the existence of long-range correlations in the score structure. In order to quantify long-range correlations, we considered the music score as a sequence of integer numbers, each of them corresponding to last common denominator units of note. By using detrended fluctuation analysis (DFA), correlations are quantified by means of the scaling exponent that reflects the type of correlations for a given distance between neighbors note. The following conclusions can be drawn from the analysis: (a) For about 10-25 neighbor note distances, correlations are similar to 1/f-noise. This is an interesting finding since it has been shown that pleasant sounds for humans display a behavior similar to 1/f noise. (b) As the neighbor note distance increases, the long-range correlations decays continuously. For some score sections, the music score behaves like non-correlated (i.e., purely random) noise. Summing up, the results show that the studied Mozart's score contains a certain degree of correlation for relatively small note distances, and becomes close to non-correlated behavior for long note distances. We considered also the sequence constructed by considering the distance between the simultaneously played notes of the two violins. Interestingly, for relatively small neighbor note distances, a scaling behavior similar to that found for individual violins is also displayed. In some sense, this is an expression of the specific structure (palindromes plus upside down construction) used by Mozart in the composition of this music score. Although we focused on a particular high-art music score, our results suggest that modern methods borrowed from statistical physics can be useful for the systematic study of music composition techniques.

Dagdug, Leonardo; Alvarez-Ramirez, Jose; Lopez, Carlos; Moreno, Rodolfo; Hernandez-Lemus, Enrique

2007-09-01

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MR imaging of acute pancreatitis: Correlation of abdominal wall edema with severity scores  

International Nuclear Information System (INIS)

Objective: To study MRI findings of abdominal wall edema (AWE) in acute pancreatitis as well as correlations between AWE and the severity of acute pancreatitis according to the MR severity index (MRSI) and the Acute Physiology And Chronic Healthy Evaluation III (APACHE III) scoring system. Materials and methods: A total of 160 patients with AP admitted to our institution between December 2009 and March 2011 were included in this study. MRI was performed within 48 h after admission. MRI findings of acute pancreatitis were noted, including AWE on the MRI. The abdominal wall area was divided into quarters, and each area involved was recorded as 1 point to score the severity of AWE. The severity of acute pancreatitis was studied using both the MRSI and the APACHE III scoring system. Spearman correlation of AWE with the MRSI and the APACHE III scoring system was analyzed. Results: In 160 patients with acute pancreatitis, 53.8% had AWE on MRI. The average AWE score was 1.2 ± 1.4 points. The prevalence of AWE was 30.5%, 64.5% and 100% in mild, moderate and severe AP, respectively, according to MRSI. AWE on MRI was correlated with MRSI scores (r = 0.441, p = 0.000). According to APACHE III scores, the averages were 2.0 ± 1.1 and 2.6 ± 1.1 points in mild AP and severe AP, respectively (P = 0.016). AWE was slightly correlated with the APACHE III scores (r = 0.222, p = 0.005). Conclusion: AWE on MRI in acute pancreatitis is common, which may be a supplementary indicator in determining the severity of AP.

2012-11-01

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MR imaging of acute pancreatitis: Correlation of abdominal wall edema with severity scores  

Energy Technology Data Exchange (ETDEWEB)

Objective: To study MRI findings of abdominal wall edema (AWE) in acute pancreatitis as well as correlations between AWE and the severity of acute pancreatitis according to the MR severity index (MRSI) and the Acute Physiology And Chronic Healthy Evaluation III (APACHE III) scoring system. Materials and methods: A total of 160 patients with AP admitted to our institution between December 2009 and March 2011 were included in this study. MRI was performed within 48 h after admission. MRI findings of acute pancreatitis were noted, including AWE on the MRI. The abdominal wall area was divided into quarters, and each area involved was recorded as 1 point to score the severity of AWE. The severity of acute pancreatitis was studied using both the MRSI and the APACHE III scoring system. Spearman correlation of AWE with the MRSI and the APACHE III scoring system was analyzed. Results: In 160 patients with acute pancreatitis, 53.8% had AWE on MRI. The average AWE score was 1.2 {+-} 1.4 points. The prevalence of AWE was 30.5%, 64.5% and 100% in mild, moderate and severe AP, respectively, according to MRSI. AWE on MRI was correlated with MRSI scores (r = 0.441, p = 0.000). According to APACHE III scores, the averages were 2.0 {+-} 1.1 and 2.6 {+-} 1.1 points in mild AP and severe AP, respectively (P = 0.016). AWE was slightly correlated with the APACHE III scores (r = 0.222, p = 0.005). Conclusion: AWE on MRI in acute pancreatitis is common, which may be a supplementary indicator in determining the severity of AP.

Yang, Ru, E-mail: yangru0904@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Jing, Zong Lin, E-mail: jzl325@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Zhang, Xiao Ming, E-mail: zhangxm@nsmc.edu.cn [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Tang, Wei, E-mail: tw-n-g-up@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Xiao, Bo, E-mail: xiaoboimaging@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Huang, Xiao Hua, E-mail: nc_hxh1966@yahoo.com.cn [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Yang, Lin, E-mail: llinyangmd@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Feng, Zhi Song, E-mail: fengzhisong@medmail.com.cn [Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China)

2012-11-15

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HRCT score in bronchiectasis: Correlation with pulmonary function tests and pulmonary artery pressure  

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Background: High resolution CT scan (HRCT) and its score have an important role in delineating pathological changes and pulmonary functional impairment in patients with bronchiectasis. Aims: To assess pulmonary function tests (PFTs) in patients with cystic and cylindrical bronchiectasis. To correlate HRCT score with PFTs and systolic pulmonary artery pressure (SPAP) in both radiological types. Materials and Methods: A cross-sectional study of patients with bronchiec...

Alzeer Abdulaziz

2008-01-01

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Leadership in a Changing World Order: Manual for the Cognitive Skills Content Analysis of Interview Data. Construct Definitions and General, Excerpting, and Scoring Criteria.  

Science.gov (United States)

This Manual contains general, excerpting, and scoring criteria for the analysis of interview data concerning cognitive skills. It also contains construct definitions for a particular set of cognitive capabilities. The method of content analysis described ...

J. Markessini

1992-01-01

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LACK OF CORRELATION BETWEEN OPIOID DOSE ADJUSTMENT AND PAIN SCORE CHANGE IN A GROUP OF CHRONIC PAIN PATIENTS  

Science.gov (United States)

Despite the increasing use of opioid analgesics for chronic pain management, it is unclear whether opioid dose escalation leads to better pain relief during chronic opioid therapy. In this study, we retrospectively analyzed clinical data collected from the Massachusetts General Hospital (MGH) Center for Pain Medicine over a 7-year period. We examined 1) the impact of opioid dose adjustment (increase or decrease) on clinical pain score, 2) gender and age differences in response to opioid therapy, and 3) the influence of clinical pain conditions on the opioid analgesic efficacy. A total of 109 subjects met the criteria for data collection. We found that neither opioid dose increase, nor decrease, correlated with point changes in clinical pain score in a subset of chronic pain patients over a prolonged course of opioid therapy (an average of 704 days). This lack of correlation was consistent regardless of the type of chronic pain including neuropathic, nociceptive, or mixed pain conditions. Neither gender nor age differences showed a significant influence on the clinical response to opioid therapy in these subjects. These results suggest that dose adjustment during opioid therapy may not necessarily alter long-term clinical pain score in a group of chronic pain patients and that individualized opioid therapy based on the clinical effectiveness should be considered to optimize the treatment outcome. Perspectives The study reports a relationship, or lack thereof, between opioid dose change and clinical pain score in a group of chronic pain patients. The study also calls for further investigation into the effectiveness of opioid therapy in the management of chronic non-malignant pain conditions.

Chen, Lucy; Vo, Trang; Seefeld, Lindsey; Malarick, Charlene; Houghton, Mary; Ahmed, Shihab; Zhang, Yi; Cohen, Abigail; Retamozo, Cynthia; Hilaire, Kristen St.; Zhang, Vivian; Mao, Jianren

2013-01-01

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Genetic correlations among body condition score, yield and fertility in multiparous cows using random regression models  

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Genetic correlations between body condition score (BCS) in lactation 1 to 3 and four economically important traits (days open, 305-days milk, fat, and protein yields recorded in the first 3 lactations) were estimated on about 12,500 Walloon Holstein cows using 4-trait random regression models. Results indicated moderate favorable genetic correlations between BCS and days open (from -0.46 to -0.62) and suggested the use of BCS for indirect selection on fertility. However, unfavorable genetic c...

2010-01-01

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Correlation between international prostate symptoms score and uroflowmetry finding in men with lower urinary tract symptoms  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Objectives: Benign prostatic hyperplasia (BPH is a common age-related urological disorder. Patients can subjectively descript their micturition habits by using the international prostate symptom score (IPSS but whether or not patients answer correlate with their uroflowmetic findings has not been validated objectively. The aim of this study was to evaluate the correlation of patient answers with findings on uroflowmetry studies.Subjects and Methods: eighty six patients with lower urinary tract symptoms (LUTS were evaluated by IPSS and uroflowmetry. IPSS was divided into voiding and storage symptoms. Waiting time, voided volume, maximum and average flow rates were recorded. The relationship between these parameters was quantified by SPSS software Pearson correlation coefficient. Results: Patients were aged 46 - 79 years old. Age did not correlate by Qmax , Qave , IPSS and voided volume. Voided volumes were 109-647ml (mean=259.5 ml. Qmax was <15ml/s in about 63% of patients (54 patients independently of age. Qmax was correlated negatively with total IPSS score and voiding symptoms but did not correlate with storage symptoms. Qave correlated only with voiding symptoms(p=0.04 but not with total IPSS and storage symptoms. Waiting time did not correlate with total IPSS, voiding and storage symptoms. Conclusion: There is a close correlation between IPSS and uroflowmetry results.uroflowmetry is a more suitable for LUTS paitents who have improper understanding the IPSS questions due to cultural or language problems. Sci Med J 2011; 10(2:205-213

Babaali N

2011-05-01

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Correlation Between Umbilical Cord pH and Apgar Score in High-Risk Pregnancy  

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Full Text Available Objective:The Apgar score as a proven useful tool for rapid assessment of the neonate is often poorly correlated with other indicators of intrapartum neonatal well-being. This study was carried out to determine the correlation between umbilical cord pH and Apgar score in high-risk pregnancies. Methods:This is a prospective cross-sectional, analytic study performed on 96 mother-fetal pairs during 2004-2005 at Shahid Yahyanejad hospital, which is affiliated to Babol University of Medical Sciences. Apgar score at 1 and 5 minutes after birth was taken and an umbilical cord blood gas analysis was done immediately after birth in both groups. Mothers came with a labor pain and were divided into high-risk and low risk if they have had any perinatal risk factors. Other data like gestational age, birth weight, need for resuscitation and admission to the newborn ward or NICU was gathered by a questionnaire for comparison between the two groups. P-value less than 0.05 was considered being significant. Findings:The gestational age and birth weight were the same in high-risk and low risk mothers. Mean umbilical artery blood pH in high-risk mothers was significantly lower than in low risk mothers (P=0.004. Mean Apgar scores at 1 and 5 minutes were significantly lower in high-risk mothers than in low risk mothers (P<0.05. According to the Kendal correlation coefficient there was no significant correlation between Apgar score at 1 and 5 minutes and umbilical cord pH in low risk group (r=0.212, P=0.1. But in high-risk group there was significant correlation between Apgar score at 1st and 5th minute and the umbilical cord pH (r=0.01, P=0.036 and r=0.176, P=0.146, respectively. Conclusion:Combination of Apgar score and umbilical cord pH measurement in high-risk pregnant mother could better detect jeopardized baby.

Mahmood Hajiahmadi

2010-12-01

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Correlation between Umbilical Cord pH and Apgar Score in High-Risk Pregnancy  

Directory of Open Access Journals (Sweden)

Full Text Available Objective:The Apgar score as a proven useful tool for rapid assessment of the neonate is often poorly correlated with other indicators of intrapartum neonatal well-being. This study was carried out to determine the correlation between umbilical cord pH and Apgar score in high-risk pregnancies.Methods:This is a prospective cross-sectional, analytic study performed on 96 mother-fetal pairs during 2004-2005 at Shahid Yahyanejad hospital, which is affiliated to Babol University of Medical Sciences. Apgar score at 1 and 5 minutes after birth was taken and an umbilical cord blood gas analysis was done immediately after birth in both groups. Mothers came with a labor pain and were divided into high-risk and low risk if they have had any perinatal risk factors. Other data like gestational age, birth weight, need for resuscitation and admission to the newborn ward or NICU was gathered by a questionnaire for comparison between the two groups. P-value less than 0.05 was considered being significant.Findings:The gestational age and birth weight were the same in high-risk and low risk mothers. Mean umbilical artery blood pH in high-risk mothers was significantly lower than in low risk mothers (P=0.004. Mean Apgar scores at 1 and 5 minutes were significantly lower in high-risk mothers than in low risk mothers (P< 0.05. According to the Kendal correlation coefficient there was no significant correlation between Apgar score at 1 and 5 minutes and umbilical cord pH in low risk group (r=0.212, P=0.1. But in high-risk group there was significant correlation between Apgar score at 1st and 5th minute and the umbilical cord pH (r=0.01, P=0.036 and r=0.176, P=0.146, respectively.Conclusion:Combination of Apgar score and umbilical cord pH measurement in high-risk pregnant mother could better detect jeopardized baby.

Mousa Ahmadpour-Kacho

2010-12-01

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Massa ventricular e critérios eletrocardiográficos de hipertrofia: avaliação de um novo escore / Ventricular mass and electrocardiographic criteria of hypertrophy: evaluation of new score  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTO: A hipertrofia ventricular esquerda (HVE) é um importante e independente fator de risco cardiovascular. Inexistem, no Brasil, estudos desenhados para testar a eficácia do eletrocardiograma (ECG) no diagnóstico desse grave processo patológico. OBJETIVO: Avaliar um novo escore eletrocardiog [...] ráfico para diagnóstico de HVE pelo ECG: soma da maior amplitude da onda S com a maior da onda R no plano horizontal, multiplicando-se o resultado pela duração do QRS [(S+R) X QRS)] e comparando-o com os critérios eletrocardiográficos clássicos. MÉTODOS: Foram analisados os ecocardiogramas e ECG de 1.204 pacientes hipertensos em tratamento ambulatorial. Avaliou-se o índice de massa do ventrículo esquerdo (IMVE) pelo ecocardiograma, firmando-se o diagnóstico de HVE quando > 96 g/m² para mulheres e > 116 g/m² para homens. No ECG analisaram-se quatro critérios clássicos de HVE, além do novo escore a ser testado. RESULTADOS: Todos os índices estudados tiveram correlação estatisticamente significativa com a massa calculada do ventrículo esquerdo (VE). Porém, o novo escore foi o que apresentou maior correlação (r = 0,564). Os outros critérios apresentaram as seguintes correlações: Romhilt-Estes (r = 0,464); Sokolow-Lyon (r = 0,419); Cornell voltagem (r = 0,377); Cornell duração (r = 0,444). Para avaliação da acurácia do índice testado, utilizou-se o ponto de corte de 2,80 mm.s. Com esse valor foram obtidas as seguintes cifras para sensibilidade e especificidade: 35,2% e 88,7%, respectivamente. CONCLUSÃO: Todos os critérios eletrocardiográficos para avaliação da massa do VE apresentaram baixa sensibilidade. O novo escore foi o que apresentou melhor correlação com o IMVE em relação aos outros avaliados. Abstract in english BACKGROUND: The left ventricular hypertrophy (LVH) is an important and independent cardiovascular risk factor. There is a scarcity of studies in Brazil designed to test the efficacy of the electrocardiogram (ECG) in the diagnosis of this important pathological process. OBJECTIVE: To evaluate a new e [...] lectrocardiographic score for the diagnosis of LVH by ECG: the sum of the highest amplitude of the S wave and the highest amplitude of the R wave on the horizontal plane, multiplied by the result of the QRS duration [(S+R) X QRS)] and comparing it with the classic electrocardiographic criteria. METHODS: The echocardiograms and ECG of 1,204 hypertensive patients receiving outpatient care were evaluated. The left ventricular mass index (LVMI) was assessed by the echocardiogram, with a diagnosis of LVH when the LVMI was > 96 g/m² for women and > 116 g/m² for men. Four classic criteria of LVH were analyzed at the ECG, in addition to the new score to be tested. RESULTS: In general, the studied ECG-LVH criteria showed significant statistical correlation to the echocardiographic LVMI. The (R+S) X QRS index, using 2.80 mm.s as the cutoff value, provided test accuracy regarding sensibility and specificity of 35.2% and 88.71%, respectively, representing the best correlation to LVMI (r=0.564) when compared to the other indexes: Romhilt-Estes (r=0.464); Sokolow-Lyon (r=0.419); Cornell voltage (r=0.377); Cornell product r=0.444). CONCLUSION: All the electrocardiographic criteria used for the assessment of the LV mass presented low sensitivity. The new score presented the best correlation with LVMI when compared to the other indexes.

Mazzaro, Cléber do Lago; Costa, Francisco de Assis; Bombig, Maria Teresa Nogueira; Luna Filho, Bráulio; Paola, Ângelo Amato Vincenzo de; Carvalho, Antonio Carlos de Camargo; Costa, William da; Fonseca, Francisco Antonio Helfenstein; Póvoa, Rui Manoel dos Santos.

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Correlation between Air Trapping Scoring and Spirometric Findings in Sulfur Mustard Exposed Patients  

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Full Text Available Background/Objective: Pulmonary complains (acute and chronic are known complications of exposure to sulfur mustard gas that for evaluation of them multiple paraclinical methods as HRCT and spirometry were used. HRCT is preferred to plain chest X-ray and conventional CT scan because better detection of both parenchymal and airway abnormalities such as bronchectasia and air trapping. Expiratory HRCT is considered as the imaging modality of choice for evaluation of air trapping."nPatients and Methods: In this study we reviewed medical records of 36 patients with documented exposure to sulfur mustard in Iran-Iraq war in order to evaluate correlation between air trapping scoring and spirometric findings."nResults: In all HRCTs air trapping was present with score ranging from 2 to 18 and mean (±SD was 7.5 (4.2 . Nineteen cases had score over than six that suggest bronchiolitis obliterans. Spirometric indices as patient FEV1, FVC, FEV1/FVC, MMEF and their percentage to mean values were obtained. We found no correlation between air trapping scoring and spirometric parameters according to r and p-values obtained by SPSS software. "nConclusion: HRCT can be diagnosed bronchiolitis obliterans in earlier stages than spirometry.

A. Adibi

2008-01-01

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Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis  

Science.gov (United States)

Background Many genetic risk variants are now well established in multiple sclerosis (MS), but the impact on clinical phenotypes is unclear. Objective To investigate the impact of established MS genetic risk variants on MS phenotypes, in well-characterized MS cohorts. Methods Norwegian MS patients (n = 639) and healthy controls (n = 530) were successfully genotyped for 61 established MS-associated single nucleotide polymorphisms (SNPs). Data including and excluding Major Histocompatibility Complex (MHC) markers were summed to a MS Genetic Burden (MSGB) score. Study replication was performed in a cohort of white American MS patients (n = 1997) and controls (n = 708). Results The total human leukocyte antigen (HLA) and the non-HLA MSGB scores were significantly higher in MS patients than in controls, in both cohorts (P << 10 ?22). MS patients, with and without cerebrospinal fluid (CSF) oligoclonal bands (OCBs), had a higher MSGB score than the controls; the OCB-positive patients had a slightly higher MSGB than the OCB-negative patients. An early age at symptom onset (AAO) also correlated with a higher MSGB score, in both cohorts. Conclusion The MSGB score was associated with specific clinical MS characteristics, such as OCBs and AAO. This study underlines the need for well-characterized, large cohorts of MS patients, and the usefulness of summarizing multiple genetic risk factors of modest effect size in genotype-phenotype analyses.

Harbo, Hanne F; Isobe, Noriko; Berg-Hansen, Pal; Bos, Steffan D; Caillier, Stacy J; Gustavsen, Marte W; Mero, Inger-Lise; Celius, Elisabeth Gulowsen; Hauser, Stephen L; Oksenberg, Jorge R; Gourraud, Pierre-Antoine

2014-01-01

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Correlation between Body Condition Score, Blood Biochemical Metabolites, Milk Yield and Quality in Algerian Montbéliarde Cattle  

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This study aimed to investigate the correlation between body condition score (BCS), blood biochemical metabolites, milk yield (MY) and quality (Mfat) in Montbéliarde cattle (31 cows) reared in 5 farms of Algerian semi arid area. The BCS was measured in dry and peak of lactation (6 weeks after calving). Blood samples were taken at the time of body condition (BC) measurement for determination of energy (Glucose, cholesterol, triglycerides and B-Hydroxybutyrate), nitrogen (urea and albumin) and...

2013-01-01

36

Schizotypal Perceptual Aberrations of Time: Correlation between Score, Behavior and Brain Activity  

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A fundamental trait of the human self is its continuum experience of space and time. Perceptual aberrations of this spatial and temporal continuity is a major characteristic of schizophrenia spectrum disturbances – including schizophrenia, schizotypal personality disorder and schizotypy. We have previously found the classical Perceptual Aberration Scale (PAS) scores, related to body and space, to be positively correlated with both behavior and temporo-parietal activation in healthy particip...

2011-01-01

37

Defining optimal cutoff scores for cognitive impairment using Movement Disorder Society Task Force criteria for mild cognitive impairment in Parkinson's disease.  

Science.gov (United States)

The recently proposed Movement Disorder Society (MDS) Task Force diagnostic criteria for mild cognitive impairment in Parkinson's disease (PD-MCI) represent a first step toward a uniform definition of PD-MCI across multiple clinical and research settings. However, several questions regarding specific criteria remain unanswered, including optimal cutoff scores by which to define impairment on neuropsychological tests. Seventy-six non-demented PD patients underwent comprehensive neuropsychological assessment and were classified as PD-MCI or PD with normal cognition (PD-NC). The concordance of PD-MCI diagnosis by MDS Task Force Level II criteria (comprehensive assessment), using a range of standard deviation (SD) cutoff scores, was compared with our consensus diagnosis of PD-MCI or PD-NC. Sensitivity, specificity, and positive and negative predictive values were examined for each cutoff score. PD-MCI subtype classification and distribution of cognitive domains impaired were evaluated. Concordance for PD-MCI diagnosis was greatest for defining impairment on neuropsychological tests using a 2 SD cutoff score below appropriate norms. This cutoff also provided the best discriminatory properties for separating PD-MCI from PD-NC compared with other cutoff scores. With the MDS PD-MCI criteria, multiple domain impairment was more frequent than single domain impairment, with predominant executive function, memory, and visuospatial function deficits. Application of the MDS Task Force PD-MCI Level II diagnostic criteria demonstrates good sensitivity and specificity at a 2 SD cutoff score. The predominance of multiple domain impairment in PD-MCI with the Level II criteria suggests not only influences of testing abnormality requirements, but also the widespread nature of cognitive deficits within PD-MCI. PMID:24123267

Goldman, Jennifer G; Holden, Samantha; Bernard, Bryan; Ouyang, Bichun; Goetz, Christopher G; Stebbins, Glenn T

2013-12-01

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Correlation of the score for subjective pain with physical disability, clinical and radiographic scores in recent onset rheumatoid arthritis  

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Abstract Background To analyse the relationship between subjective pain score and other measures of clinical, radiographic and functional status; in particular Larsen radiographic scores and Health Assessment Questionnaire (HAQ); in patients with severe rheumatoid arthritis (RA) with a disease duration of less than 3 years. Methods In this cross sectional study of 105 patients with RA (76 women, 29 men: mean age 50.93; mean disease duration 15.86 months; 71% rhe...

2002-01-01

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Evaluation of cytogenetic damage in workers exposed to microwave radiation of GEM radar using new criteria in scoring micronucleus test  

International Nuclear Information System (INIS)

The cytokinesis-block micronucleus assay is one of the standard cytogenetic tools employed in the assessment of chromosomal damage subsequent to the exposure to genotoxic/cytotoxic agents on human cells. Within the frame of this study, the cytokinesis-block micronucleus assay was used to assess the baseline cytogenetic damage in binuclear lymphocytes in workers occupationally exposed to microwave radiation of GEM radar by virtue of measuring the frequency of micronuclei, nucleoplasmic bridges and nuclear buds. Microwave radiation of GEM radar equipment acts within microwave field of 10 ?W/cm2 to 10 mW/cm2 and frequency range of 1.5 GHz to 10.9 GHz that has contradictory cytogenetic effect on human cells and DNA molecule. For that reason we used new criteria in scoring micronucleus assay that allows us to measure nucleoplasmic bridges and nuclear buds in addition to micronucleus frequency for more accurate effect on possible damage on the level of the cells. Parameters of the micronucleus test were studied in workers occupationally exposed to microwave radiation of GEM radar and in corresponding unexposed control subjects. It was found that in the subjects who were occupationally exposed to microwave radiation, the levels of micronuclei increased and showed interindividual variations. In addition, new parameters that were measured; nucleoplasmic bridges and nuclear buds, were detected in exposed group in compare to control group that did not shown this type of damage. Differences between mean group values were statistically significant (P<0.05). Our study indicates that micronucleus assay is a very useful tool in the assessment of cytogenetic damage of individuals exposed to microwave radiation of GEM radar equipment. On the basis of the micronucleus frequency and frequencies of nucleoplasmic bridges and nuclear buds, the micronucleus technique with an easy and short-term application and with an easy scoring can be used for detection of damage induced by this type of radiation. (author)

2010-05-01

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Correlations of visual scores, carcass traits, feed efficiency and retail product yield in Nellore cattle  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The growing use of visual scores (VS) and ultrasound (US) for carcass evaluation in breeding programs, calls for a knowledge of the relationships between these traits and other relevant characteristics, such as feed efficiency and production of commercial cuts. The objective of this study was to eva [...] luate correlations between body visual scores and carcass traits identified by ultrasound (US) and feed efficiency (FE), carcass weight (HCW), dressing percentage (DP) and retail product yield (RPY) in beef cattle. Nellore cattle (male), 42 non-castrated [NCAST] and 44 castrated [CAST]) were evaluated by both VS and US, at the postweaning (15-month old) and finishing phases (21-month old). Visual scores of conformation (C), precocity (P) and muscling (M) were assessed and the backfat thickness (UBFT), rump fat thickness (URFT) and ribeye area (UREA) were measured by ultrasound. Gain-to-feed (G:F) ratio and residual feed intake (RFI) were measured in feedlot. Hot carcass weight, DP and RPY were determined at harvest. Non-castrated cattle had greater HCW and RPY but lower UBFT and URFT than CAST. Postweaning VS and US were poorly correlated with FE in both sexual conditions. Finishing VS were negatively correlated with G:F in CAST and finishing URFT was negatively correlated with RPY in NCAST. The relationship of VS and US with feed efficiency and meat yield is affected by age at the date of evaluation and by castration. Feed efficiency is not related to the yield of meat cuts in Nellore cattle

Cancian, Paulo Henrique; Gomes, Rodrigo da Costa; Manicardi, Fernando Ricardo; Ianni, Andrea Cristina; Bonin, Marina de Nadai; Leme, Paulo Roberto; Silva, Saulo da Luz e.

 
 
 
 
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Estimates of genetic parameters for visual scores and their correlation with production and reproductive traits in Brahman cattle  

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The objective of this study was to evaluate the association of visual scores of body structure, precocity and muscularity with production (body weight at 18 months and average daily gain) and reproductive (scrotal circumference) traits in Brahman cattle in order to determine the possible use of these scores as selection criteria to improve carcass quality. Covariance components were estimated by the restricted maximum likelihood method using an animal model that included contemporary group as...

Tássia Souza Bertipaglia; Luis Orlando Duitama Carreño; Carlos Henrique Cavallini Machado; Cristiana Andrighetto; Ricardo da Fonseca

2012-01-01

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Correlation of a quantitative videocapillaroscopic score with the development of digital skin ulcers in scleroderma patients  

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Full Text Available Background: Systemic sclerosis (SSc is an autoimmune disease characterized by fibrosis of the skin and visceral organs. The microangiopathy is early detectable in the course of the disease by nailfold videocapillaroscopy (NVC, a non-invasive technique with a high diagnostic value. Objective: Aim of our study was to evaluate the feasibility of a quantitative score and its correlation with the digital skin ulcers, which frequently complicate SSc microangiopathy. Methods: We retrospectively analysed the NVC of 65 SSc patients, performed by 200x videocapillaroscopy connected to image analyse software (Videocap; DS MediGroup, Milan, Italy. The analysis of NVC images included: total number of capillaries in the distal row (N, maximum diameter (D and number of giant capillaries (M, M/N ratio and percentage of M, presence/absence of micro-haemorrhages and tortuosity. Results: 21/65 SSc patients experienced digital ulcers within three months after the NVC examination. The N, D, M/N, and percentage of M significantly correlated with the appearance of ischemic ulcers. A multiple regression analysis showed a statistically significant correlation for N, M/N and D, while sensitivity and specificity of these parameters were unsatisfactory. A capillaroscopic score, according to the formula D·M/N2, showed a high specificity and sensibility (93.2% and 85.7% respectively; area under ROC curve: 0.918 to predict the appearance of digital ulcers. Conclusions: This capillaroscopic score may represent a feasible and simple tool in SSc patients’ assessment. The routinely use of this parameter might permit to recognize and to preventively treat SSc patients at high risk to develop digital ulcers.

A. Antonelli

2011-09-01

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Ecological validity and neuroanatomical correlates of the NIH EXAMINER executive composite score.  

Science.gov (United States)

Executive functions refer to a constellation of higher-level cognitive abilities that enable goal-oriented behavior. The NIH EXAMINER battery was designed to assess executive functions comprehensively and efficiently. Performance can be summarized by a single score, the "Executive Composite," which combines measures of inhibition, set-shifting, fluency, and working memory. We evaluated the ecological validity of the Executive Composite in a sample of 225 mixed neurological patients and controls using the Frontal Systems Behavior Scale (FrSBe), an informant-based measure of real-world executive behavior. In addition, we investigated the neuroanatomical correlates of the Executive Composite using voxel-based morphometry in a sample of 37 participants diagnosed with dementia, mild cognitive impairment, or as neurologically healthy. The Executive Composite accounted for 28% of the variance in Frontal Systems Behavior Scale scores beyond age. Even after including two widely used executive function tests (Trails B and Stroop) as covariates, the Executive Composite remained a significant predictor of real-world behavior. Anatomically, poorer scores on the Executive Composite were associated with smaller right and left dorsolateral prefrontal volumes, brain regions critical for good executive control. Taken together, these results suggest that the Executive Composite measures important aspects of executive function not captured by standard measures and reflects the integrity of frontal systems. PMID:23764015

Possin, Katherine L; LaMarre, Amanda K; Wood, Kristie A; Mungas, Dan M; Kramer, Joel H

2014-01-01

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Clinical Criteria for Airway Assessment: Correlations with Laryngoscopy and Endotracheal Intubation Conditions  

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Full Text Available Difficult intubation, inadequate ventilation and esophageal intubation are the principal causes of death or brain damage related to airway manipulation. The objective of this cross-sectional study was to correlate a preanesthetic evaluation that may be capable of predicting a difficult intubation with the conditions encountered at laryngoscopy and endotracheal intubation. Eighty-one patients submitted to general anesthesia were evaluated at a preanesthetic consultation according to the modified Mallampati classification, the Wilson score and the American Society of Anesthesiologists (ASA difficult airway algorithm. Findings were then correlated with the Cormack-Lehane classification and with the number of attempts at endotracheal intubation. No statistically significant correlations were found between the patients’ Mallampati classification and their Cormack-Lehane grade or between the Mallampati classification and the number of attempts required to achieve endotracheal intubation. Laryngoscopy proved difficult in four patients and in all of these cases the Wilson score had been indicative of a possibly difficult airway, highlighting its good predicting sensitivity. However, the specificity of this test was low, since another 24 patients had the same Wilson score but were classified as Cormack-Lehane I/II. Moreover, two patients who had a Wilson score ? 4 were also classified as Cormack-Lehane grade I/II. The study concluded that the Wilson score, although seldom used in clinical practice, is a highly sensitive predictor of a difficult airway; its specificity, however, is low.

Gustavo Henrique S. Wanderley

2013-08-01

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Correlacao do EuroSCORE com o surgimento de lesao renal aguda pos-operatoria em cirurgia cardiaca / Correlation of the EuroSCORE with the onset of postoperative acute kidney injury in cardiac surgery  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Verificar se há correlação entre valores do EuroSCORE e o risco de desenvolver lesão renal aguda em pacientes submetidos à cirurgia cardíaca. MÉTODOS: Estudo retrospectivo, realizado em hospital terciário, em pacientes consecutivos com indica&# [...] 231;ão para abordagem cirúrgica cardíaca (valvares, isquêmicas e congênitas) entre outubro de 2010 a julho de 2011. RESULTADOS: Foram avaliados cem pacientes. Destes, seis foram excluídos (cinco por doença renal ou terapia dialítica prévias e um devido a informações incompletas no prontuário médico). As principais indicações cirúrgicas foram revascularização miocárdica em 55 pacientes (58,5% dos casos) e trocas valvares em 28 pacientes (29,8%). Conforme o EuroSCORE, 55 pacientes foram classificados como risco alto (58,5%), 27 pacientes como risco médio (28,7%) e 12 pacientes como risco baixo (12,8%). No período pós-operatório, 31 pacientes (33%) evoluíram com aumento da creatinina sérica (18 (19,1%) RIFLE "R"; 7 (7,4%) RIFLE "I"; e 6 (6,5%) RIFLE "F"). Na amostra considerada de alto risco pelos critérios do EuroSCORE, 24 pacientes (43,6%) apresentaram comprometimento renal agudo. Nos pacientes classificados como de médio e de baixo risco, ocorreu lesão renal aguda em 18,5 e 16,6% dos casos, respectivamente. A associação entre a estratificação de risco (baixo, médio e alto) do EuroSCORE e o escore do RIFLE pós-operatório foi estatisticamente significante (p=0,03). CONCLUSÃO: Na população estudada, houve correlação estatisticamente significante entre o EuroSCORE e o risco de desenvolvimento de lesão renal aguda no pós-operatório de cirurgia cardíaca. Abstract in english OBJECTIVE: The objective of this study was to assess the correlation between the European System for Cardiac Operative Risk Evaluation (EuroSCORE) score and the risk of developing acute kidney injury in cardiac surgery patients. METHODS: This retrospective study was conducted at a tertiary hos [...] pital on consecutive cardiac surgery patients (e.g., valvular, ischemic and congenital heart diseases) between October 2010 and July 2011. RESULTS: One hundred patients were assessed. Among the 100 patients, six were excluded, including five because of prior kidney disease or dialysis therapy and one because of incomplete medical records. The primary surgical indications were myocardial revascularization in 55 patients (58.5% of cases) and valve replacement in 28 patients (29.8%). According to the EuroSCORE, 55 patients were classified as high risk (58.5%), 27 patients as medium risk (28.7%) and 12 patients as low risk (12.8%). In the postoperative period, patients were classified with the Risk, Injury, Failure, Loss and End-stage kidney disease (RIFLE) score. Among the 31 patients (33%) who displayed an increase in serum creatinine, 18 patients (19.1%) were classified as RIFLE "R" (risk), seven patients (7.4%) were classified as RIFLE "I" (injury) and six patients (6.5%) were classified as RIFLE "F" (failure). Among the patients who were considered to be high risk according to the EuroSCORE criteria, 24 patients (43.6%) showed acute kidney injury. Among the patients who were classified as medium or low risk, acute kidney injury occurred in 18.5 and 16.6% of the cases, respectively. The correlations between risk stratification (low, medium and high) and the EuroSCORE and postoperative RIFLE scores were statistically significant (p=0.03). CONCLUSION: In the studied population, there was a statistically significant correlation between the EuroSCORE and the risk of developing acute kidney injury in the postoperative period after cardiac surgery.

Moura, Edmilson Bastos de; Bernardes Neto, Saint-Clair Gomes; Amorim, Fabio Ferreira; Viscardi, Renato Camargo.

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Evaluation of selection criteria in Cicer arietinum L. using correlation coefficients and path analysis  

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The study pertaining to the evaluation of selection criteria in chickpea using correlation coefficients and path analysis was carried out in the Department of Plant Breeding and Genetics, University of Agriculture, Faisalabad for a period of two years. Experimental material comprised of twenty chickpea genotypes. The genotypes demonstrated highly significant differences (P<0.01) for all the traits studied. The results of correlation analysis revealed that that grain yield plant-1 had signific...

2009-01-01

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Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Effective R&D and strict quality control of a broad range of foods, beverages, and pharmaceutical products require objective taste evaluation. Advanced taste sensors using artificial-lipid membranes have been developed based on concepts of global selectivity and high correlation with human sensory score. These sensors respond similarly to similar basic tastes, which they quantify with high correlations to sensory score. Using these unique properties, these sensors can quantify the basic taste...

Yoshikazu Kobayashi; Masaaki Habara; Hidekazu Ikezazki; Ronggang Chen; Yoshinobu Naito; Kiyoshi Toko

2010-01-01

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High correlation between net promoter score and the development of consumers' willingness to pay (Empirical evidence from European mobile markets)  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This paper shows that the correlation between the Net Promoter Score and consumers' Willingness To Pay in five European mobile markets is very strong. The Net Promoter Score is provided by a survey and the Willingness To Pay is calculated using the Spokes Model which is an economic model based on horizontal differentiation among firms. The model input data (firms' revenues, number of subscribers and profits) are provided by Merill Lynch, Bank of America. The well-known correlation between Net...

Jeanjean, Franc?ois

2011-01-01

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Big Macs and Eigenfactor Scores: Don't Let Correlation Coefficients Fool You  

CERN Document Server

The Eigenfactor Metrics provide an alternative way of evaluating scholarly journals based on an iterative ranking procedure analogous to Google's PageRank algorithm. These metrics have recently been adopted by Thomson-Reuters and are listed alongside the Impact Factor in the Journal Citation Reports. But do these metrics differ sufficiently so as to be a useful addition to the bibliometric toolbox? Davis (2008) has argued otherwise, based on his finding of a 0.95 correlation coefficient between Eigenfactor score and total citations for a sample of journals in the field of medicine. This conclusion is mistaken; here we illustrate the basic statistical fallacy to which Davis succumbed. We provide a complete analysis of the 2006 Journal Citation Reports and demonstrate that there are important differences between the information provided by the Eigenfactor Metrics and that provided by Impact Factor and Total Citations.

West, Jevin; Bergstrom, Carl

2009-01-01

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Correlation between Body Condition Score, Blood Biochemical Metabolites, Milk Yield and Quality in Algerian Montbéliarde Cattle  

Directory of Open Access Journals (Sweden)

Full Text Available This study aimed to investigate the correlation between body condition score (BCS, blood biochemical metabolites, milk yield (MY and quality (Mfat in Montbéliarde cattle (31 cows reared in 5 farms of Algerian semi arid area. The BCS was measured in dry and peak of lactation (6 weeks after calving. Blood samples were taken at the time of body condition (BC measurement for determination of energy (Glucose, cholesterol, triglycerides and B-Hydroxybutyrate, nitrogen (urea and albumin and mineral (calcium metabolites. Milk yield was recorded in the 6th week of lactation (peak. A sample of milk for each cow was used to determinate milk fat, density and acidity. The results showed a significant decrease in postpartum BCS accompanied by an increase in cholesterol and B-Hydroxybutyrate (BHB concentration. The correlation analysis showed that BHB concentration in pre calving was negatively correlated with BCS (r=-0.321; P<0.05 and cholesterol (r=-0.308; P<0.05. In postpartum, BCS was negatively correlated with cholesterol (r=-0.416; P<0.05, urea (r=-0.366; P<0.05 and BHB (r=-0.487; P<0.05. However, the level of milk production decreased significantly with high glucose (r=-0.449; P<0.05 and BHB (r=-0.514; P<0.05. The fat content increased significantly with blood triglycerides (r=0.681; P<0.05 and BHB (r=0.522; P<0.05 concentration, indicating a high mobilization of body reserves used for the synthesis of milk fat. In conclusion, it can be assumed that the rate of BHB seems to be the best indicator of the nutritional status of dairy cows that determines their production level and quality.

Charef-Eddine Mouffok1,2,*, Toufik Madani1,2, Lounis Semara1, Nadhira Ayache1 and Amina Rahal1

2013-04-01

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Genetic correlations between body condition scores and fertility in dairy cattle using bivariate random regression models.  

Science.gov (United States)

Genetic correlations between body condition score (BCS) and fertility traits in dairy cattle were estimated using bivariate random regression models. BCS was recorded by the Swiss Holstein Association on 22,075 lactating heifers (primiparous cows) from 856 sires. Fertility data during first lactation were extracted for 40,736 cows. The fertility traits were days to first service (DFS), days between first and last insemination (DFLI), calving interval (CI), number of services per conception (NSPC) and conception rate to first insemination (CRFI). A bivariate model was used to estimate genetic correlations between BCS as a longitudinal trait by random regression components, and daughter's fertility at the sire level as a single lactation measurement. Heritability of BCS was 0.17, and heritabilities for fertility traits were low (0.01-0.08). Genetic correlations between BCS and fertility over the lactation varied from: -0.45 to -0.14 for DFS; -0.75 to 0.03 for DFLI; from -0.59 to -0.02 for CI; from -0.47 to 0.33 for NSPC and from 0.08 to 0.82 for CRFI. These results show (genetic) interactions between fat reserves and reproduction along the lactation trajectory of modern dairy cows, which can be useful in genetic selection as well as in management. Maximum genetic gain in fertility from indirect selection on BCS should be based on measurements taken in mid lactation when the genetic variance for BCS is largest, and the genetic correlations between BCS and fertility is strongest. PMID:17868080

De Haas, Y; Janss, L L G; Kadarmideen, H N

2007-10-01

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Modified Chrispin-Norman chest radiography score for cystic fibrosis: observer agreement and correlation with lung function  

Energy Technology Data Exchange (ETDEWEB)

To test observer agreement and two strategies for possible improvement (consensus meeting and reference images) for the modified Chrispin-Norman score for children with cystic fibrosis (CF). Before and after a consensus meeting and after developing reference images three observers scored sets of 25 chest radiographs from children with CF. Observer agreement was tested for line, ring, mottled and large soft shadows, for overinflation and for the composite modified Chrispin-Norman score. Correlation with lung function was assessed. Before the consensus meeting agreement between observers 1 and 2 was moderate-good, but with observer 3 agreement was poor-fair. Scores correlated significantly with spirometry for observers 1 and 2 (-0.72correlation with lung function, but agreement for the modified Chrispin-Norman score did not improve further. Consensus meetings and reference images improve among-observer agreement for the modified Chrispin-Norman score, but good agreement was not achieved among all observers for the modified Chrispin-Norman score and for bronchial line and ring shadows. (orig.)

Jong, P.A. de; Achterberg, J.A.; Kessels, O.A.M.; Beek, F.J. [Department of Radiology, University Medical Center Utrecht, Wilhelmina Children' s Hospital, Utrecht (Netherlands); Ginneken, B. van; Hogeweg, L. [Radboud University Nijmegen Medical Centre, Department of Radiology, Nijmegen (Netherlands); Image Sciences Institute, University Medical Center Utrecht, Utrecht (Netherlands); Terheggen-Lagro, S.W.J. [University Medical Center Utrecht, Wilhelmina Children' s Hospital, Department of Pediatric Pulmonology, Utrecht (Netherlands)

2011-04-15

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Modified Chrispin-Norman chest radiography score for cystic fibrosis: observer agreement and correlation with lung function  

International Nuclear Information System (INIS)

To test observer agreement and two strategies for possible improvement (consensus meeting and reference images) for the modified Chrispin-Norman score for children with cystic fibrosis (CF). Before and after a consensus meeting and after developing reference images three observers scored sets of 25 chest radiographs from children with CF. Observer agreement was tested for line, ring, mottled and large soft shadows, for overinflation and for the composite modified Chrispin-Norman score. Correlation with lung function was assessed. Before the consensus meeting agreement between observers 1 and 2 was moderate-good, but with observer 3 agreement was poor-fair. Scores correlated significantly with spirometry for observers 1 and 2 (-0.72< R<-0.42, P < 0.05), but not for observer 3. Agreement with observer 3 improved after the consensus meeting. Reference images improved agreement for overinflation and mottled and large shadows and correlation with lung function, but agreement for the modified Chrispin-Norman score did not improve further. Consensus meetings and reference images improve among-observer agreement for the modified Chrispin-Norman score, but good agreement was not achieved among all observers for the modified Chrispin-Norman score and for bronchial line and ring shadows. (orig.)

2011-04-01

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Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study  

DEFF Research Database (Denmark)

BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) are associated with decline in cognition, gait, mood, and urinary continence. Associations may depend on the method used for measuring WMH. We investigated the ability of different WMH scoring methods to detect differences in WMH load between groups with and without symptoms. METHODS: We used data of 618 independently living elderly with WMH collected in the Leukoaraiosis And DISability (LADIS) study. Subjects with and without symptoms of depression, gait disturbances, urinary incontinence, and memory decline were compared with respect to WMH load measured qualitatively using 3 widely used visual rating scales (Fazekas, Scheltens, and Age-Related White Matter Changes scales) and quantitatively with a semiautomated volumetric technique and an automatic lesion count. Statistical significance between groups was assessed with the chi2 and Mann-Whitney tests. In addition, the punctate and confluent lesion type with comparable WMH volume were compared with respect to the clinical data using Student t test and chi2 test. Direct comparison of visual ratings with volumetry was done using curve fitting. RESULTS: Visual and volumetric assessment detected differences in WMH between groups with respect to gait disturbances and age. WMH volume measurement was more sensitive than visual scores with respect to memory symptoms. Number of lesions nor lesion type correlated with any of the clinical data. For all rating scales, a clear but nonlinear relationship was established with WMH volume. CONCLUSIONS: Visual rating scales display ceiling effects and poor discrimination of absolute lesion volumes. Consequently, they may be less sensitive in differentiating clinical groups

van Straaten, EC; Fazekas, F

2006-01-01

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Correlation between parathormone and coronary artery calcium scoring and coronary artery disease  

Directory of Open Access Journals (Sweden)

Full Text Available Background: It has been shown that coronary artery calcium scoring (CACS can be used as a diagnostic method in coronary artery disease (CAD. The relationship between CACS and calcium metabolism in the body has been shown. The arterial calcification is an organized process similar to bone formation which is controled by parathormone (PTH. The relationship between PTH as an osteoregulatory factor and CACS has been also indicated. In this study, we tried to assess the value of serum PTH and CACS in patients planned to undergo coronary angiography (CAG in order to find a simple, cost -benefit, noninvasive way, for ruling in/out obstructive CAD. Methods: In a cross sectional study in Imam Khomeini hospital in 1390, CACS by using non-enhanced multi detector computed tomography (MDCT and measurement of serum level of PTH, Calcium and Phosphate were done in 178 patients suspected to CAD which were scheduled to undergo coronary angiography serum PTH was measured by immuno-radiometric assay (IRMA and serum Ca and Phosphate were measured by spectrophotometry methods. Results: Of 178 Patients, 50 patients were females and 126 patients were male. Mean age of them was 56.2±11.6. The correlation coefficient between CACS and Gensini score (0.507, P<0.001, PTH (0.037, P=0.693, Ca (0.062, P=0.499 and Phosphate (0.061, P=0.506 were obtained. The level of serum PTH in the patients with and without coronary artery disease were 21.8±11.6 pg/dl, 23.2±11.5 pg/dl (P=0.427 respectively. Conclusion: Our study showed association between CACS and CAD that was statistically significant while no relationship was found between PTH, CACS and CAD.

Zand Parsa AF

2013-05-01

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Correlation between the Gleason Scores of Needle Biopsies and Radical Prostatectomy Specimens.  

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Full Text Available Background: The Gleason score has been shown to offer important information withregard to prognosis and therapy for patients with adenocarcinoma of theprostate gland. In this study, Gleason scores, as determined by 18-gauge coreneedle biopsies, were compared with both Gleason scores and the pathologicalstaging of corresponding radical prostatectomy specimens.Methods: Records of 78 consecutive patients undergoing a radical retropubic prostatectomybetween 1998 and 2002 were reviewed. In total, 78 patients wereenrolled, all of whom had been diagnosed with adenocarcinoma by transrectalneedle biopsies using an 18-gauge automated spring-loaded biopsy gun.Results: Grading errors were greatest with well-differentiated tumors. The accuracywas 6 (23% for Gleason scores of 2-4 on needle biopsy. Of the 36 evaluablepatients with Gleason scores of 5-7 on needle biopsy, 28 (78% were gradedcorrectly. All of the Gleason scores of 8-10 on needle biopsy were gradedcorrectly. Eighteen (33% of 54 patients with a biopsy Gleason score of < 7had their cancer upgraded to above 7. Tumors in 6 patients (60% with both aGleason score < 7 on the needle biopsy and a Gleason score of 7 for theprostatectomy specimen were confined to the prostate.Conclusion: The potential for grading errors is greatest with well-differentiated tumorsand in patients with a Gleason score of < 7 on the needle biopsy. Predictionsusing Gleason scores are sufficiently accurate to warrant its use with all needlebiopsies, recognizing that the potential for grading errors is greatest withwell-differentiated tumors.

Biing-Yir Shen

2003-12-01

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Increased expression of EphA1 protein in prostate cancers correlates with high Gleason score.  

Science.gov (United States)

The erythropoietin-producing hepatocellular (Eph) family of receptor tyrosine kinases regulates a multitude of physiological and pathological processes. EphA1 is the first member of Eph superfamily and is involved in carcinogenesis. The aim of this study was to investigate the expression of EphA1 in prostate cancers cell lines and the tissues, then explore the correlation with the clinicopathologic parameters. The EphA1 transcript expression in prostate cancer cell lines was detected by Quantitative real-time PCR. The expression of EphA1 protein in 138 prostate cancer tissue samples and 21 benign prostate hyperplasia samples were checked by using immunohistochemical staining. EphA1 mRNA was high expressed in LNCap, moderately expressed in 22RV1 and Du145, and lost in PC3. Loss of expression of EphA1 transcript was related to hypermethylation of CpG island around the translation start site. EphA1 protein was differentially expressed in prostate cancers and hyperplasia. Increased expression of EphA1 protein was more frequently detected in prostate cancers than in hyperplasia (P = 0.02), and more often detected in prostate cancer with high Gleason score (P < 0.001). Our data indicate that EphA1 receptor may have roles in carcinogenesis and progression of prostate cancer, and can be a potentially useful target for prognostic and therapeutic application. PMID:24040450

Peng, Libo; Wang, Haiyan; Dong, Yingchun; Ma, Jie; Wen, Juanjuan; Wu, Jinrong; Wang, Xueqing; Zhou, Xiaojun; Wang, Jiandong

2013-01-01

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Hepatic energy metabolism correlated with pathology score in rats chronically fed ethanol  

Energy Technology Data Exchange (ETDEWEB)

We repeatedly measured in vivo levels of hepatic phosphorylated metabolites in alcohol-fed rats using non-invasive 31P MRS to evaluate their relation to the severity of the pathologic changes of alcoholic liver disease (ALD). Five pairs of Wister rats were pair-fed with a liquid diet plus ethanol or an isocaloric amount of dextrose via an implanted intragastric tube for up to 6 months (mo). For MRS, the rats were sedated, air was provided by a face mask, and the diet was infused to maintain high blood alcohol levels. {sup 31}P MRS spectra were obtained using a CYCLOPS pulse-acquire sequence, 200 scans, and a 2s recycle delay. The inorganic phosphate (Pi)/ATP peak area ratio was found to be consistently higher in the alcohol-fed rats (E) compared to the pair-fed controls (C). The sugar phosphate/ATP ratio tended to be higher in E when compared to C. Cytosolic pH measured by the chemical shift of the Pi peak showed no significant differences between E and C. The monthly liver biopsies from E showed more severe steatosis, necrosis, and fibrosis with time of feeding and the Pi/ATP ratio was positively correlated with the scored histological changes. These results suggest that a low hepatic energetic state is associated with the progression of ALD pathology.

Takahasi, H.; Geoffrion, Y.; Butler, K.W.; French, S.W. (Univ. of Ottawa, Ontario (Canada))

1989-02-09

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PERFORMANCE RANKING OF DIPLOMA INSTITUTIONS BASED ON SOME SELECTED CRITERIA BY APPLYING SCORING MODEL- A SAMPLE STUDY  

Directory of Open Access Journals (Sweden)

Full Text Available The assessment of institutional performance based on various contributing parameters is of paramount importance for an institute and is not an easy task. Present studies aim at assessing the institutional level performance of some selected diploma level institutions of West Bengal by using Scoring Model (SM - as a multiple criterion decision making technique. Application of this model also shows a comparison of institutions based on their performance with respect to specific contributing parameters.

Dipankar Bose

2011-10-01

60

Rheumatoid arthritis bone erosion volumes on CT and MRI: reliability and correlations with erosion scores on CT, MRI and radiography.  

DEFF Research Database (Denmark)

OBJECTIVES: To investigate intramodality and intermodality agreements of CT and MRI erosion volumes in metacarpophalangeal (MCP) joints in rheumatoid arthritis (RA), and to compare the volumes with erosion scores for CT, MRI and radiography. METHODS: In total, 17 patients with RA and four healthy controls underwent unilateral CT, MRI and radiography of second to fifth MCP joints in one hand. Erosion volumes (using OSIRIS software) and scores were determined from CT, MRI and radiography (scores only). RESULTS: CT, MRI and radiography detected 77, 62 and 12 erosions, respectively. On CT, the mean erosion volume was 26 mm(3) (median 10; range 0 to 248) and 30 mm(3) (18; 1 to 163) on MRI. Total erosion volumes (per patient/control) were 97 mm(3) (29; 0 to 485) on CT and 90 mm(3) (46; 0 to 389) on MRI. For volumes, Spearman correlation coefficients were 0.96 to 0.99 (CT vs CT), 0.95 to 0.98 (MRI vs MRI) and 0.64 to 0.89 (CT vs MRI), all p<0.01. MRI erosion volumes correlated with the Outcome Measures in Rheumatology Clinical Trials/Rheumatoid Arthritis Magnetic Resonance Imaging Score (OMERACT RAMRIS) erosion scores (0.91 to 0.99; p<0.01) and the Sharp/van der Heijde erosion score (0.49 to 0.63; p<0.01). CONCLUSION: Very high intramodality and high intermodality agreements of CT and MRI erosion volumes were found, encouraging further testing in longitudinal studies. A close correlation with CT and MRI erosion volumes supports the OMERACT RAMRIS erosion score as a valid measure of joint destruction in RA.

Møller Døhn, Uffe; Ejbjerg, Bo J

2007-01-01

 
 
 
 
61

Genetic correlation patterns between somatic cell score and protein yield in the Italian Holstein-Friesian Population  

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Genetic parameters for somatic cell score (SCS) in the Italian Holstein-Friesian population were estimated addressing the pattern of genetic correlation with protein yield in different parities (first, second, and third) and on different days in milk within each parity. Three approaches for parameter estimation were applied using random samples of herds from the national database of the Italian Holstein Association. Genetic correlations for lactation measures (305-d protein yield and lactatio...

Samore, A.; Groen, A. F.; Boettcher, P.; Jamrozik, J.; Canavesi, F.; Bagnato, A.

2008-01-01

62

Correlation of sperm penetration assay score with polyspermy rate in in-vitro fertilization  

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Abstract Background The sperm penetration assay (SPA) is used to predict the fertilizing capacity of sperm. Thus, some programs rely on SPA scores to formulate insemination plans in conjunction with in-vitro fertilization (IVF) cycles. The purpose of this study was to evaluate if a relationship exists between SPA scores and polyspermy rates during conventional IVF cycles. Methods A total of 1350 consecutive IVF patients using conventional IVF insemination were e...

2005-01-01

63

Evaluation of selection criteria in Cicer arietinum L. using correlation coefficients and path analysis  

Directory of Open Access Journals (Sweden)

Full Text Available The study pertaining to the evaluation of selection criteria in chickpea using correlation coefficients and path analysis was carried out in the Department of Plant Breeding and Genetics, University of Agriculture, Faisalabad for a period of two years. Experimental material comprised of twenty chickpea genotypes. The genotypes demonstrated highly significant differences (P<0.01 for all the traits studied. The results of correlation analysis revealed that that grain yield plant-1 had significant genotypic and highly significant phenotypic relationship with primary branches, pods plant-1, seeds plant-1, seeds pod-1 and total biological yield. The path coefficient analysis based on grain yield plant-1, as a dependent variable, exposed that all of the other traits, except days to flowering, days to maturity and secondary branches exhibited positive direct effects. The path analysis confirmed that biological yield followed by number of seeds pod-1, 100-grain weight, had the maximum positive direct influence on grain yield plant-1. Therefore, this study suggests that chickpea improvement progarmme could be based on these characters as selection criteria.

Muhammad Amjad Ali

2009-03-01

64

Near-Infrared Spectroscopy Correlates with Established Histological Scores in a Miniature Pig Model of Cartilage Regeneration  

Science.gov (United States)

Near-Infrared Spectroscopy (NIRS) could be of clinical relevance in modern cartilage regeneration.In a miniature pig model correlation of measurements and histologic scores have never been used before. The data analysis was part of an animal project that investigated the effects of seeding a chondrogenic and osteogenic scaffold with a bone-marrow-derived cell concentrate and reports the histological and mechanical properties. We created 20 osteochondral defects in the femoral condyles of 10 miniature pigs.The defects were left empty (E), filled with the grafted cylinder upside down (U), or with a combined scaffold (S) containing a spongy bone cylinder covered with a collagen membrane. In the fourth group, the same scaffolds were implanted but seeded with a stem cell concentrate (S+BMCC). The animals were euthanized after 3 months, and histologic and spectrometric analyses were performed. NIRS measurements were significantly higher in the central area of the defects of group S+BMCC compared to the central area of the defects of group U. In all groups, a correlation between NIRS and the histologic scores could be demonstrated though on different levels. In the central area, a good NIRS measurement correlates with low (good) histologic scores. In group E and group S, this negative correlation was significant (p=0.01). For the first time, NIRS was successfully used to evaluate osteochondral constructs in a miniature pig model.

Guenther, Daniel; Liu, Chaoxu; Horstmann, Hauke; Krettek, Christian; Jagodzinski, Michael; Haasper, Carl

2014-01-01

65

Correlation between serum free fatty acids levels and Gensini score in elderly patients with coronary heart disease  

Science.gov (United States)

Objectives To investigate the relationship between serum free fatty acids (FFAs) levels and the severity of coronary artery lesions in elderly patients with coronary heart disease (CAD). Methods A total of 172 elderly patients who underwent coronary angiography were divided into CAD group (n = 128) and non-CAD group (n = 44) according to the results of coronary angiography. Serum FFAs and lipid levels were measured and the Gensini score were calculated. Results No matter the differences between age, gender and the usage of statins or not, there was no statistical significance in FFAs levels (P > 0.05). In terms of the Gensini score, it was higher in patients aged 70–79 years than in patients 60–69 years old [15.00 (5.00, 34.00) vs. 10.00 (2.00, 24.00), P 495.25) mEq/L, P 0.05). Furthermore, the FFAs levels were positively correlated with the Gensini score (r = 0.394, P = 0.005). Regression analysis showed that the FFAs levels were related to the Gensini score independently after adjusting for the other risk factors. Conclusions The serum FFAs levels were associated with the Gensini score in elderly patients with CAD. It might indicate FFAs as a biomarker predicting the severity of coronary artery lesions.

He, Li-Yun; Zhao, Jun-Feng; Han, Jiang-Li; Shen, Shan-Shan; Chen, Xu-Jiao

2014-01-01

66

Contrast-enhanced ultrasonography for the detection and characterization of prostate cancer: Correlation with microvessel density and Gleason score  

Energy Technology Data Exchange (ETDEWEB)

Aim: To determine whether there is a correlation between the peak intensity of the lesion at contrast-enhanced ultrasonography and the microvessel density (MVD) and Gleason score in biopsy specimens of prostate cancer. Materials and methods: Contrast-enhanced ultrasonography using cadence-contrast pulse sequence (CPS) technology was performed in 147 patients with suspected prostate cancer before biopsy. An auto-tracking contrast quantification (ACQ) software was used to analyse the peak intensity (PI) of the lesion. The Gleason score and MVD immunoreactivity were determined in the prostate biopsy specimens. Ultrasound findings were correlated with biopsy findings. Results: Prostate cancer was detected in 73 of 147 patients. The PI values of prostate cancer patients were significantly higher than those of non-malignant patients [9.81 (4.23) versus 5.69 (3.19) dB; p < 0.01]. The mean (SD) PIs of prostate cancer lesions with a Gleason score of 6-9 were 7.08 (3.80), 8.65 (4.08), 9.76 (3.75), and 9.85 (4.13) dB, respectively. The PI value increased significantly with a higher Gleason score (p < 0.01). The mean (SD) MVDs observed in prostate cancer lesions with a Gleason score of 6-9 were 52.50 (10.54), 56.85 (10.31), 59.91 (9.29), and 66.04 (11.82), respectively. There was a positive correlation between PI and MVD in prostate cancer, with a correlation coefficient of 0.617. No correlation was found between PI value and age, prostate specific antigen (PSA) or prostate specific antigen density (PSAD) level (p > 0.05). Conclusion: The PI obtained by CPS harmonic ultrasonography appears to be of value as an indicator of MVD and increases with a higher Gleason score. CPS harmonic ultrasonography could be promising as a useful imaging technique in the detection and characterization of prostate cancer.

Jiang, J. [Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092 (China); Chen, Y., E-mail: joychen_1266@163.com [Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092 (China); Zhu, Y.; Yao, X.; Qi, J. [Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092 (China)

2011-08-15

67

Quantification of Emphysema with a Three-Dimensional Chest CT Scan: Correlation with the Visual Emphysema Scoring on Chest CT, Pulmonary Function Tests and Dyspnea Severity  

Energy Technology Data Exchange (ETDEWEB)

We wanted to prospectively evaluate the correlation between the quantification of emphysema using 3D CT densitometry with the visual emphysema score, pulmonary function tests (PFT) and the dyspnea score in patients with chronic obstructive pulmonary disease (COPD). Non-enhanced chest CT with 3D reconstruction was performed in 28 men with COPD (age 54-88 years). With histogram analysis, the total lung volume, mean lung density and proportion of low attenuation lung volume below predetermined thresholds were measured. The CT parameters were compared with the visual emphysema score, the PFT and the dyspnea score. A low attenuation lung volume below -950 HU was well correlated with the DLco and FEV{sub 1}/FVC. A Low attenuation lung volume below -950 HU and -930 HU was correlated with visual the emphysema score. A low attenuation lung volume below -950 HU was correlated with the dyspnea score, although the correlations between the other CT parameters and the dyspnea score were not significant. Objective quantification of emphysema using 3D CT densitometry was correlated with the visual emphysema score. A low attenuation lung volume below -950 HU was correlated with the DLco, the FEV{sub 1}/FVC and the dyspnea score.

Park, Hyun Jeong; Hwang, Jung Hwa [Dept. of Radiology, Soonchunhyang University Seoul Hospital, Seoul (Korea, Republic of)

2011-09-15

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Brochopulmonary dysplasia: New high resolution computed tomography scorting system and correlation between the high resolution computed tomography score and clinical severity  

International Nuclear Information System (INIS)

To develop an high resolution computed tomography (HRCT) scoring system for the assessment of bronchopulmonary dysplasia (BPD) and determine its usefulness as compared with the chest radiographic score. Forty-two very low-birth-weight preterm infants with BPD (25 male, 17 female) were prospectively evaluated with HRCT performed at the mean age of 39.1-week postmenstrual age. Clinical severity of BPD was categorized as mild, moderate or severe. The HRCT score (0-36) of each patient was the sum of the number of bronchopulmonary segments with 1) hyperaeration and 2) parenchymal lesions (linear lesions, segmental atelectasis, consolidation and architectural distortion), respectively. We compared the HRCT scores with the chest radiographic scores (the Toce system) in terms of correlation with clinical severity. The HRCT score had good interobserver (r = 0.969, p < 0.001) and intraobserver (r = 0.986, p < 0.001) reproducibility. The HRCT score showed better correlation (r = 0.646, p < 0.001) with the clinical severity of BPD than the chest radiographic score (r = 0.410, p = 0.007). The hyperaeration score showed better correlation (r = 0.738, p < 0.001) with the clinical severity of BPD than the parenchymal score (r = 0.523, p < 0.001). We have developed a new HRCT scoring system for BPD based on the quantitative evaluation of pulmonary abnormalities of BPD consisting of the hyperaeration score and the parenchymal score. The HRCT score shows better correlation with the clinical severity of BPD than the radiographic score.

2013-04-01

69

DNA repair pathway gene expression score correlates with repair proficiency and tumor sensitivity to chemotherapy.  

Science.gov (United States)

Mutagenesis is a hallmark of malignancy, and many oncologic treatments function by generating additional DNA damage. Therefore, DNA damage repair is centrally important in both carcinogenesis and cancer treatment. Homologous recombination (HR) and nonhomologous end joining are alternative pathways of double-strand DNA break repair. We developed a method to quantify the efficiency of DNA repair pathways in the context of cancer therapy. The recombination proficiency score (RPS) is based on the expression levels for four genes involved in DNA repair pathway preference (Rif1, PARI, RAD51, and Ku80), such that high expression of these genes yields a low RPS. Carcinoma cells with low RPS exhibit HR suppression and frequent DNA copy number alterations, which are characteristic of error-prone repair processes that arise in HR-deficient backgrounds. The RPS system was clinically validated in patients with breast or non-small cell lung carcinomas (NSCLCs). Tumors with low RPS were associated with greater mutagenesis, adverse clinical features, and inferior patient survival rates, suggesting that HR suppression contributes to the genomic instability that fuels malignant progression. This adverse prognosis associated with low RPS was diminished if NSCLC patients received adjuvant chemotherapy, suggesting that HR suppression and associated sensitivity to platinum-based drugs counteract the adverse prognosis associated with low RPS. Therefore, RPS may help oncologists select which therapies will be effective for individual patients, thereby enabling more personalized care. PMID:24670686

Pitroda, Sean P; Pashtan, Itai M; Logan, Hillary L; Budke, Brian; Darga, Thomas E; Weichselbaum, Ralph R; Connell, Philip P

2014-03-26

70

[Distal radius fracture with dorsal displacement: correlation between functional score, reduction quality and fixation].  

Science.gov (United States)

Appropriate treatment for fractures of the distal radius with dorsal displacement remains a subject of debate. Intrafocal pinning is the most widely used technique in France. Plate fixation has been developed to avoid secondary displacement and stiffness sometimes observed after pinning. We compared three osteosynthesis techniques for the same type of fracture (extra-articular with dorsal displacement). Sixty-two consecutive patients underwent osteosynthesis using the following techniques successively: posterior plates (20 patients mean age 59.9 years [range 25-87 years]), intra- and extrafocal pinning (22 patients mean age 55.6 years [range 17-83 years]), the anterior plate (20 patients mean age 57.1 years [range 17-78 years]). An independent operator evaluated all patients using the Herzberg, Gartland and Werley and Dash scores. The radial slope in the frontal plane, sagittal tilt, and ulnar variance were measured and compared between the preoperative and last follow-up values. Kruskall-Wallis or ANOVA were applied as appropriate for continuous variables and the Chi-square test for non-continuous variables. Psyloid process rather than its base. For these extra-articular fractures, pinning can provide good functional results like anterior plating but each treatment has advantages that functional analysis detected. PMID:21087886

Huard, S; Leclerc, G; Sergent, P; Serre, A; Gasse, N; Lepage, D; Jeunet, L; Garbuio, P; Obert, L

2010-12-01

71

Time course of lesion development in patients with acute brain stem infarction and correlation with NIHSS score  

International Nuclear Information System (INIS)

Background and purpose: diffusion weighted magnetic resonance imaging (MRI) is highly sensitive in detecting acute supratentorial cerebral ischemia and Diffusion Weighted Imaging (DWI) lesion size has been shown to correlate strongly with the neurologic deficit in middle cerebral artery territory stroke. However, data concerning infratentorial strokes are rare. We examined the size and evolution of acute brain stem ischemic lesions and their relationship to neurological outcome. Methods: brain stem infarctions of 11 patients were analyzed. We performed DWI in all patients and in 7/11 patients within 24 h, T2W sequences within the first 2 weeks (10/11 patients) and follow-up MRI (MR2) within 3-9 months (median 4.8 months) later (12/12 patients). Lesion volumes were compared with early and follow-up neurologic deficit as determined by National Institutes of Health Stroke Scale (NIHSS) score. Results: the relative infarct volumes--with MR2 lesion size set to 100%--decreased over the time (P<0.02) with a mean shrinking factor of 3.3 between DWI (MR0) and the follow-up MRT (P<0.02), and 1.6 between early T2W (MR1) and MR2 (P<0.04). The mean DWI volume size (MR0) was larger than the early T2W (P<0.02). Although neurological outcome was good in all patients (mean NIHSS score of 1.3 at follow-up), early NIHSS and follow-up NIHSS scores were strongly correlated (r=0.9, P<0.00). NIHSS score at follow-up was highly correlated with lesion size of DWI (MR0; r=0.71, P<0.04) and T2W of MR1 (r=0.86, P<0.001). Conclusions: in this study, we saw a shrinking of the brain stem infarct volume according to clinical improvement of patients. Great extension of restricted diffusion in the acute stage does not necessarily implicate a large resulting infarction or a bad clinical outcome

2001-09-01

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Distribution of brain infarction in children with tuberculous meningitis and correlation with outcome score at 6 months  

International Nuclear Information System (INIS)

Prognostic indicators for tuberculous meningitis (TBM) offer realistic expectations for parents of affected children. Infarctions affecting the basal ganglia are associated with a poor outcome. To correlate the distribution of infarction in children with TBM on CT with an outcome score (OS). CT brain scans in children with TBM were retrospectively reviewed and the distribution of infarctions recorded. The degree of correlation with OS at 6 months was determined. There was a statistically significant association between all sites of infarction (P = 0.0001-0.001), other than hemispheric (P = 0.35), and outcome score. There was also a statistically significant association between all types of infarction (P = 0.0001-0.02), other than hemispheric (P = 0.05), and overall poor outcome. The odds ratio for poor outcome with bilateral basal ganglia and internal capsule infarction was 12. The odds ratio for poor outcome with 'any infarction' was 4.91 (CI 2.24-10.74), with 'bilateral infarctions' 8.50 (CI 2.49-28.59), with basal ganglia infarction 5.73 (CI 2.60-12.64), and for hemispheric infarction 2.30 (CI 1.00-5.28). Infarction is associated with a poor outcome unless purely hemispheric. MRI diffusion-weighted imaging was not part of this study, but is likely to play a central role in detecting infarctions not demonstrated by CT. (orig.)

2006-12-01

73

Correlation between a new visual prostate symptom score (VPSS) and uroflowmetry parameters in men with lower urinary tract symptoms  

Scientific Electronic Library Online (English)

Full Text Available SciELO South Africa | Language: English Abstract in english OBJECTIVE: A visual prostate symptom score (VPSS) compared with the international prostate symptom score (IPSS) for evaluation of lower urinary tract symptoms (LUTS) can be completed without physician assistance by a significantly larger proportion of men with limited education. We aimed to evaluate [...] the correlation of the VPSS and IPSS with uroflowmetry parameters. METHODS: Men with LUTS were requested to complete the IPSS and VPSS, consisting of pictograms to evaluate urinary frequency, nocturia, force of the stream and quality of life. The maximum (Qmax) and average urinary flow rate (Qave), voided volume (VV) and post-void residual (PVR) urine volumes were measured. Statistical analysis was performed using the Mann-Whitney and Spearman's tests. RESULTS: The study included 93 men (mean age 64 years, range 33 -85), with VV >150 ml in 66 (71%) and 150 ml there were significant negative correlations between the IPSS and Qmax (r=-0.30, p=0.016), the IPSS and Qave (r=-0.29, p=0.018), the VPSS and Qmax (r=-0.38, p

C F, Heyns; C L E, van der Walt; A E, Groeneveld.

74

Genetic correlation patterns between somatic cell score and protein yield in the Italian Holstein-Friesian population.  

Science.gov (United States)

Genetic parameters for somatic cell score (SCS) in the Italian Holstein-Friesian population were estimated addressing the pattern of genetic correlation with protein yield in different parities (first, second, and third) and on different days in milk within each parity. Three approaches for parameter estimation were applied using random samples of herds from the national database of the Italian Holstein Association. Genetic correlations for lactation measures (305-d protein yield and lactation SCS) were positive in the first parity (0.31) and close to zero in the second (0.01) and third (0.09) parities. These results indicated that larger values of SCS were genetically associated with increased production. The second and third sets of estimates were based on random regression test-day models, modeling the shape of lactation curve with the Wilmink function and fourth-order Legendre polynomials, respectively. Genetic correlations from both random regression models showed a specific pattern associated with days in milk within and across parities. Estimates varied from positive to negative in the first and second parity, and from null to negative in the third parity. Patterns were similar for both random regression models. The average overall correlation between SCS and protein yield was zero or slightly positive in the first lactation and ranged from zero to negative in later lactations. Correlation estimates differed by parity and stage of lactation. They also demonstrated the dubiousness of applying a single genetic correlation measure between SCS and protein in setting selection strategies. Differences in magnitude and the sign of genetic correlations between SCS and yields across and within parities should be accounted for in selection schemes. PMID:18832227

Samoré, A B; Groen, A F; Boettcher, P J; Jamrozik, J; Canavesi, F; Bagnato, A

2008-10-01

75

Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.  

Science.gov (United States)

The tumor suppressor gene PTEN/MMAC-1/TEP-1 (referred to hereafter as PTEN) maps to chromosome 10q23 and encodes a dual specificity phosphatase. The PTEN protein negatively regulates cell migration and cell survival and induces a G1 cell cycle block via negative regulation of the phosphatidylinositol 3'-kinase/protein kinase B/Akt signaling pathway. PTEN is frequently mutated or deleted in both prostate cancer cell lines and primary prostate cancers. A murine polyclonal antiserum was raised against a glutathione S-transferase fusion polypeptide of the COOH terninus of PTEN. Archival paraffin tissue sections from 109 cases of resected prostate cancer were immunostained with the antiserum, using DU145 and PC-3 cells as positive and negative controls, respectively. PTEN expression was seen in the secretory cells. Cases were considered positive when granular cytoplasmic staining was seen in all tumor cells, mixed when areas of both positive and negative tumor cell clones were seen, and negative when adjacent benign prostate tissue but not tumor tissue showed positive staining. Seventeen cases (15.6%) of prostate cancer were positive, 70 cases (64.2%) were mixed, and 22 cases (20.2%) were negative. Total absence of PTEN expression correlated with the Gleason score (P = 0.0081) and correlated more significantly with a Gleason score of 7 or higher (P = 0.0004) and with advanced pathological stage (American Joint Committee on Cancer stages T3b and T4; P = 0.0078). Thus, loss of PTEN protein is correlated with pathological markers of poor prognosis in prostate cancer. PMID:10485474

McMenamin, M E; Soung, P; Perera, S; Kaplan, I; Loda, M; Sellers, W R

1999-09-01

76

Interspecies Correlation Estimation - Applications in Water Quality Criteria and Ecological Risk Assessment  

Science.gov (United States)

Water quality criteria (WQC) designate the maximum concentrations of water-borne toxicants that do not adversely affect specific protection goals under certain natural conditions. As the foundation of water quality standards, WQC provide a critical scientific basis for environmen...

77

Cerebral correlates and statistical criteria of cross-modal face and voice integration  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Perception of faces and voices plays a prominent role in human social interaction, making multisensory integration of cross-modal speech a topic of great interest in cognitive neuroscience. How to define po- tential sites of multisensory integration using functional magnetic resonance imaging (fMRI) is currently under debate, with three statistical criteria frequently used (e.g., super-additive, max and mean criteria). In the present fMRI study, 20 participants were scanned in a block design ...

Love, S. A.; Pollick, F. E.; Latinus, M.

2011-01-01

78

Correlation of volumetric mismatch and mismatch of Alberta Stroke program Early CT scores on CT perfusion maps  

Energy Technology Data Exchange (ETDEWEB)

We aimed to determine if volumetric mismatch between tissue at risk and tissue destined to infarct on computed tomography perfusion (CTP) can be described by the mismatch of Alberta Stroke Program Early CT Score (ASPECTS). Forty patients with nonlacunar middle cerebral artery infarct <6 h old who had CTP on admission were retrospectively reviewed. Two raters segmented the lesion volume on mean transit time (MTT) and cerebral blood volume (CBV) maps using thresholds of >6 s and <2.0 mL per 100 g, respectively. Two other raters assigned ASPECTS to the same MTT and CBV maps while blinded to the volumetric data. Volumetric mismatch was deemed present if {>=}20%. ASPECTS mismatch (=CBV ASPECTS - MTT ASPECTS) was deemed present if {>=}1. Correlation between the two types of mismatches was assessed by Spearman's coefficient ({rho}). ROC curve analyses were performed to determine the optimal ASPECTS mismatch cut point for volumetric mismatch {>=}20%, {>=}50%, {>=}100%, and {>=}150%. Median volumetric mismatch was 130% (range 10.9-2,031%) with 31 (77.5%) being {>=}20%. Median ASPECTS mismatch was 2 (range 0-6) with 26 (65%) being {>=}1. ASPECTS mismatch correlated strongly with volumetric mismatch with {rho} = 0.763 [95% CI 0.585-0.870], p < 0.0001. Sensitivity and specificity for volumetric mismatch {>=}20% was 83.9% [95% CI 65.5-93.5] and 100% [95% CI 65.9-100], respectively, using ASPECTS mismatch {>=}1. Volumetric mismatch {>=}50%, {>=}100%, and {>=}150% were optimally identified using ASPECTS mismatch {>=}1, {>=}2, and {>=}2, respectively. On CTP, ASPECTS mismatch showed strong correlation to volumetric mismatch. ASPECTS mismatch {>=}1 was the optimal cut point for volumetric mismatch {>=}20%. (orig.)

Lin, Ke; Rapalino, Otto; Lee, Benjamin; Do, Kinh G.; Sussmann, Amado R.; Pramanik, Bidyut K. [NYU Medical Center/Bellevue Hospital, Department of Radiology, New York, NY (United States); Law, Meng [Mount Sinai Medical Center, Department of Radiology, New York, NY (United States)

2009-01-15

79

Lack of a correlation between micronucleus scores in cytokinesis - blocked lymphocytes and cancer patient response to radiotherapy  

International Nuclear Information System (INIS)

In the present study, we have used a retrospective approach in order to investigate a range of radiosensitivities measured by micronucleus (Mn) assay in lymphocytes of head and neck, and cervix cancer patients. There were treatment failures and tumor free patients in both groups. The aim therefore was to establish the possible role of MN scores in identifying these different responses. Peripheral blood samples were collected from 15 patients for head and neck cancer group, and from 16 patients for cervix group. The samples were irradiated with 3 Gy of Co-60 gamma irradiation. Micronucleus values which determine the cellular radiosensitivity ranged between 0.03 and 0.39 with the average value of 0.23 for head and neck cancer patients and ranged between 0.05 and 0.48 with the average value of 0.25. Statistically, there was no difference between radiosensitivity of two patients groups (p=0.33). In cervix cancer group, there were four treatment failure patients and there were six treatment failure patients in head and neck cancer group. MN frequencies of all the failure patients generated more micronuclei following in vitro test irradiation and were above the average sensitivity value of 0.25. The results in the present paper provide an evidence that although we investigated two different cancer groups, the quantitative similarities in the radiosensitivity range measured by MN assay exist. However, within the radiosensitivity range of each group, there was lack of a correlation between MN scores and patient response. It could be concluded that MN test applied to lymphocytes does not have a predictive value in patient prognosis. (authors)

2003-01-01

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Correlation of P-wave Duration and Dispersion in Patients with Ischemia-Induced During Treadmill Exercise Testing with Duke Score  

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Prolonged P-wave duration and dispersion have been reported during transient coronary artery occlusions such as angioplasty, spontaneous angina episodes and exercise induced myocardial ischemia. The association of Duke score and P-Wave Dispersion (PWD) has been poor explored. To determine the correlation of Duke score with PWD during Treadmill Exercise Testing (TET) and this sensitivity. Study population included 78 patients with suspected coronary artery disease (64 men, mean age 53.3 years)...

Rose Mary Ferreira Lisboa da Silva; Livio Bruno Santos Cunha; Loyara Rocha Miranda Teixeira; Leandro Araujo Rios Teixeira Dias, Marcelo Saraiva Araujo E.

2011-01-01

 
 
 
 
81

Refining criteria for diagnosis of cutaneous infections caused by herpes viruses through correlation of morphology with molecular pathology  

Directory of Open Access Journals (Sweden)

Full Text Available BACKGROUND: Infections of the skin by herpes viruses do not always present themselves in typical fashion. Early diagnosis, however, is crucial for appropriate treatment. Polymerase chain reaction (PCR allows diagnosis and differential diagnosis of herpes virus infections, but the method is not yet available in large parts of the world, where diagnosis is made based on morphology alone. AIM: To refine criteria for the diagnosis of herpes virus infections of the skin by way of correlation of clinical and histopathologic findings with results of PCR studies. METHODS: We studied 75 clinically diagnosed patients of "zoster," "varicella," and "herpes simplex", to correlate clinical and histopathological findings with results of PCR studies on paraffin embedded biopsy specimens. RESULTS: Clinical suspicion of infection by herpes viruses was confirmed by histopathology in 37% of the cases and by PCR studies in 65% of the cases. Zoster was frequently misdiagnosed as infection with herpes simplex viruses (30%. When diagnostic signs of herpes virus infection were encountered histopathologically, PCR confirmed the diagnosis in 94%. By way of correlation with results of PCR studies, initial lesions of herpes virus infections could be identified to have a distinctive histopathological pattern. Herpetic folliculitis appeared to be a rather common finding in zoster, it occurring in 28% of the cases. CONCLUSION: We conclude that correlation of clinical and histopathological features with results of PCR studies on one and the same paraffin embedded specimen permits identification of characteristic morphologic patterns and helps to refine criteria for diagnosis both clinically and histopathologically.

Böer Almut

2006-01-01

82

Correlation of CT angiographic pulmonary artery obstruction scores with right ventricular dysfunction and clinical outcome in patients with acute pulmonary embolism  

Energy Technology Data Exchange (ETDEWEB)

Objective: To correlate CTA pulmonary artery obstruction scores (OS) with right ventricular dysfunction (RVD) and clinical outcome in patients with acute pulmonary embolism (PE). Materials and methods: In a prospective study of 50 patients (66 ± 12.9 years) with PE pulmonary artery OS (Qanadli, Mastora, and Mastora central) were assessed by two radiologists. To assess RVD all patients underwent echocardiography within 24 h. Furthermore, RVD on CT was assessed by calculating the right ventricular/left ventricular (RV/LV) diameter ratios on transverse (RV/LVtrans) and four-chamber views (RV/LV4ch) as well as the RV/LV volume ratio (RV/LVvol). OS were correlated with RVD and the occurrence of adverse clinical outcomes (defined as death, need for intensive care treatment, or cardiac insufficiency ?NYHA III). Results: Mean Mastora, Qanadli, and Mastora central OS were 26.4 ± 17.7, 12.6 ± 9.9 and 7.5 ± 9, respectively. Echocardiography demonstrated moderate and severe RVD in 10 and 5 patients, respectively. Patients with moderate and severe RVD showed significantly higher Mastora central scores than patients without RVD (14 ± 10.8 vs. 5.9 ± 7.8 [p = 0.05]; 17.6 ± 13.2 vs. 5.9 ± 7.8 [p = 0.038]). A relevant correlation (i.e. r ? 0.6) between OS and CT parameters for RVD were only found for the Mastora score and the Mastora central score (RV/LV4ch: r = 0.61 and 0.68, RV/LVvol: r = 0.61 and 0.6). 18 patients experienced an adverse clinical outcome. None of the OS differed significantly between patients with and without adverse clinical outcome. Conclusion: Pulmonary artery obstruction scores can differentiate between patients with and without RVD. However, in this study, obstruction scores were not correlated to adverse clinical outcome.

Apfaltrer, P., E-mail: paul.apfaltrer@medma.uni-heidelberg.de [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Henzler, T.; Meyer, M. [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Roeger, S.; Haghi, D.; Gruettner, J.; Süselbeck, T. [Department of Internal Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Wilson, R.B.; Schoepf, U.J. [Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Drive, MSC 226, Charleston, SC 29401 (United States); Schoenberg, S.O.; Fink, C. [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany)

2012-10-15

83

Correlation of CT angiographic pulmonary artery obstruction scores with right ventricular dysfunction and clinical outcome in patients with acute pulmonary embolism  

International Nuclear Information System (INIS)

Objective: To correlate CTA pulmonary artery obstruction scores (OS) with right ventricular dysfunction (RVD) and clinical outcome in patients with acute pulmonary embolism (PE). Materials and methods: In a prospective study of 50 patients (66 ± 12.9 years) with PE pulmonary artery OS (Qanadli, Mastora, and Mastora central) were assessed by two radiologists. To assess RVD all patients underwent echocardiography within 24 h. Furthermore, RVD on CT was assessed by calculating the right ventricular/left ventricular (RV/LV) diameter ratios on transverse (RV/LVtrans) and four-chamber views (RV/LV4ch) as well as the RV/LV volume ratio (RV/LVvol). OS were correlated with RVD and the occurrence of adverse clinical outcomes (defined as death, need for intensive care treatment, or cardiac insufficiency ?NYHA III). Results: Mean Mastora, Qanadli, and Mastora central OS were 26.4 ± 17.7, 12.6 ± 9.9 and 7.5 ± 9, respectively. Echocardiography demonstrated moderate and severe RVD in 10 and 5 patients, respectively. Patients with moderate and severe RVD showed significantly higher Mastora central scores than patients without RVD (14 ± 10.8 vs. 5.9 ± 7.8 [p = 0.05]; 17.6 ± 13.2 vs. 5.9 ± 7.8 [p = 0.038]). A relevant correlation (i.e. r ? 0.6) between OS and CT parameters for RVD were only found for the Mastora score and the Mastora central score (RV/LV4ch: r = 0.61 and 0.68, RV/LVvol: r = 0.61 and 0.6). 18 patients experienced an adverse clinical outcome. None of the OS differed significantly between patients with and without adverse clinical outcome. Conclusion: Pulmonary artery obstruction scores can differentiate between patients with and without RVD. However, in this study, obstruction scores were not correlated to adverse clinical outcome

2012-10-01

84

Complex versus Simple Modeling for DIF Detection: When the Intraclass Correlation Coefficient (?) of the Studied Item Is Less Than the ? of the Total Score  

Science.gov (United States)

Previous research has demonstrated that differential item functioning (DIF) methods that do not account for multilevel data structure could result in too frequent rejection of the null hypothesis (i.e., no DIF) when the intraclass correlation coefficient (?) of the studied item was the same as the ? of the total score. The current study extended…

Jin, Ying; Myers, Nicholas D.; Ahn, Soyeon

2014-01-01

85

An Examination of the National Educational Longitudinal Study (NELS:88) Database To Probe the Correlation between Computer Use in School and Improvement in Test Scores.  

Science.gov (United States)

Examines the database for the National Educational Longitudinal Study (NELS:88) for connections between student use of computers in math and science classes and their academic success. Finds that computer use was significantly correlated with gender, socioeconomic status, parent's level of education, and Item Response Theory (IRT) scores

Weaver, Gabriela C.

2000-01-01

86

Smoothing and Equating Methods Applied to Different Types of Test Score Distributions and Evaluated with Respect to Multiple Equating Criteria. Research Report. ETS RR-11-20  

Science.gov (United States)

In equating research and practice, equating functions that are smooth are typically assumed to be more accurate than equating functions with irregularities. This assumption presumes that population test score distributions are relatively smooth. In this study, two examples were used to reconsider common beliefs about smoothing and equating. The…

Moses, Tim; Liu, Jinghua

2011-01-01

87

Correlation between Bhalla score and spirometry in children and adolescents with Cystic Fibrosis / Correlação entre escore de Bhalla e espirometria em crianças e adolescentes com fibrose cística  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Objetivo: correlacionar os achados da tomografia computadorizada de alta resolução (TCAR) do tórax, com base no escore de Bhalla, com os dados clínicos e a espirometria em crianças e adolescentes com fibrose cística (FC), além de estudar a concordância entre dois médicos radiologistas para o escor [...] e de Bhalla e suas categorias. Métodos: foram avaliados os prontuários e os exames de 23 pacientes do ambulatório. Os itens avaliados foram idade, peso, altura, escore Z altura/idade, escore Z peso/ idade, índice de massa corpórea (IMC), saturação de O2, espirometria e escore de Bhalla. Resultados: os pacientes avaliados tinham média de idade de 17,4±5,7 anos, sendo 15 do sexo feminino e 8 do sexo masculino. Houve boa correlação entre o escore de Bhalla e a espirometria (CVF-r = 0,718, p 70% já apresentavam alterações na nota final do escore de Bhalla. Na análise da concordância entre os examinadores, foi encontrado coeficiente kappa de 0,81 (p Abstract in english Objective: to correlate the findings of high resolution computed tomography of the chest based on the Bhalla score with the clinical data and spirometry in children and adolescents with cystic fibrosis, and to study the concordance between two radiologists for the Bhalla score and its categories. [...] Methods: we evaluated the medical records of 23 patients from the outpatient clinic. The items evaluated included age, weight, height, height/age Z-score, weight/age Z-score, body mass index (BMI), O2 saturation, spirometry and Bhalla score. Results: the patients had a mean age of 17.4 years ± 5.7 years, with fifteen females and eight males. There was good correlation between Bhalla score and spirometry (FVC-r =0.718, p 70% already had changes in their final Bhalla score. In the analysis of the concordance between the examiners a Kappa coefficient of 0.81 (p

Flavia Fajardo Linhares, Pereira; Cassio da Cunha, Ibiapina; Cristina Gonçalves, Alvim; Paulo Augusto Moreira, Camargos; Reginaldo, Figueiredo; Jesiana Ferreira, Pedrosa.

88

CORRELATION OF PEMPHIGUS VULGARIS ANTIBODY TITERS BY INDIRECT IMMUNOFLUORESCENCE WITH ACTIVITY OF DISEASE BASED ON PEMPHIGUS AREA AND ACTIVITY SCORE (PAAS  

Directory of Open Access Journals (Sweden)

Full Text Available Indirect immunofluorescence (IIF has been used to identify and measure autoantibody levels in pemphigus vulgaris but data about relationship between clinical severity of disease and antibody titers by IIF have been conflicting. We conducted this cross-sectional study to correlate the severity of oral and/or cutaneous involvement in patients with pemphigus vulgaris based on Pemphigus Area and Activity Score with IIF titers. Sixty-one new pemphigus vulgaris patients were included in this study. Human prepuce was used as substrate for IIF and assessment of disease severity was based on Pemphigus Area and Activity Score. The mean±SD age was 44.04±30.46 years, with a range of 18 to 79 years. IIF was positive in 56 (91.8% patients. There was a significant relationship between total disease score and IIF titers ((P<0.001. Also a significant relationship was found between skin score (P=0.04 and mucosal score (P=0.04 with IIF titers. Our results show that there is a significant relationship between disease activity based on Pemphigus Area and Activity Score and antibody titers by IIF. Further studies are recommended to determine the usefulness of this technique for monitoring disease.

H. Mortazavi

2008-06-01

89

Locally Advanced Rectal Cancer Patients Receiving Radio-Chemotherapy: A Novel Clinical-Pathologic Score Correlates With Global Outcome  

International Nuclear Information System (INIS)

Purpose: To determine the importance of downstaging of locally advanced rectal cancer after neoadjuvant treatment. Methods and Materials: The study included all consecutive patients with locally advanced rectal cancer who underwent neoadjuvant treatment (chemotherapy and/or radiotherapy) in different Italian centers from June 1996 to December 2003. A novel score was used, calculated as the sum of numbers obtained by giving a negative or positive point, respectively, to each degree of increase or decrease in clinical to pathologic T and N status. Results: A total of 317 patients were eligible for analysis. Neoadjuvant treatments performed were as follows: radiotherapy alone in 75 of 317 patients (23.7%), radiotherapy plus chemotherapy in 242 of 317 patients (76.3%). Worse disease-free survival was observed in patients with a lower score (Score 1 = -3 to +3 vs. Score 2 = +4 to +7; p = 0.04). Conclusions: Our results suggest that a novel score, calculated from preoperative and pathologic tumor and lymph node status, could represent an important parameter to predict outcome in patients receiving neoadjuvant treatment for rectal cancer. The score could be useful to select patients for adjuvant chemotherapy after neoadjuvant treatment and surgery.

2009-12-01

90

Proctitis after external-beam radiotherapy for prostate cancer classified by Vienna Rectoscopy Score and correlated with EORTC/RTOG score for late rectal toxicity: Results of a prospective multicenter study of 166 patients  

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Purpose: To evaluate the Vienna Rectoscopy Score (VRS) as a feasible and effective tool for detecting and classifying pathologic changes in the rectal mucosa after radiotherapy (RT) for prostate cancer, and, also, to correlate its findings with the European Organization for Research and Treatment of Cancer (EORTC)/Radiation Therapy Oncology Group (RTOG) score for late rectal toxicity. Methods and Materials: A total of 486 patients with localized prostate cancer underwent external-beam RT up to 70 or 74 Gy within an Austrian-German prospective multicenter trial. In 166 patients, voluntary rectal sigmoidoscopy was performed before and at 12 and/or 24 months after RT. Pathologic findings such as telangiectasia, congested mucosa, and ulcers were graded (Grades 0-3) and summarized according to the VRS. Late rectal side effects (EORTC/RTOG) were documented and correlated with the corresponding VRS. Results: Before RT, 99% had a VRS score of 0. The median follow-up was 40 months. Overall, a late rectal side effects grade or score 1-3 was detected in 43% by EORTC/RTOG compared with 68% by VRS (p < 0.05). Grades 0, 1, 2, and 3 late rectal side effects were found using EORTC/RTOG in 57%, 11%, 28%, and 3%, respectively; the corresponding percentages were 32%, 22%, 32%, and 14% for a VRS of 0, 1, 2, and 3, respectively. A significant coherence between the VRS and EORTC/RTOG was found (p < 0.01). Conclusions: The VRS is a feasible and effective tool for describing and classifying pathologic findings in the rectal mucosa after RT within a multicenter trial. The VRS and EORTC/RTOG showed a high coherence. However the VRS was significantly more sensitive

2007-01-01

91

Heritabilities and genetic correlations of body condition score and muscularity with productive traits and their trend functions in Italian Simmental cattle  

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With the aim to study the genetics of energy and muscle balance in the Italian Simmental breed, the objectives of this study were: i) the estimation of the genetic parameters for body condition score (BCS) and muscularity (MU) score; ii) the estimation of genetic correlations of BCS and MU with productive traits; iii) the estimation of the expected pattern of BCS and MU over lactation. A total of 47,839 records of first-parity lactating cows, collected from 1999 to 2007 in 2794 herds, were us...

2013-01-01

92

Diagnostic yield of MRI for audiovestibular dysfunction using contemporary referral criteria: correlation with presenting symptoms and impact on clinical management  

International Nuclear Information System (INIS)

Aim: To investigate the diagnostic yield of T2-weighted magnetic resonance imaging (MRI) screening for vestibular schwannoma and other relevant conditions in the setting of audiovestibular symptoms, given the more liberal contemporary referral criteria. To determine whether presenting clinical symptoms correlate with imaging outcome in order to guide future protocols for MRI referral. Materials and methods: Eight hundred and eighty-one consecutive MRI examinations performed in patients with audiovestibular dysfunction were reviewed. Clinical indications and findings were recorded. Case notes were reviewed in patients with positive imaging findings. Two-way, cross-tabulation, Chi-square analysis was performed to assess the relationship between presenting symptoms and imaging outcome. Results: Twelve of the 881 (1.4%) were positive for vestibular schwannoma. A further four of 881 (0.4%) revealed other relevant conditions. Incidental conditions, felt to be irrelevant to the presenting symptoms, were noted in 12 of the 881 (1.4%). In all 12 cases that were positive for vestibular schwannoma, either tinnitus or hearing loss was present. Conclusion: The yield for T2-weighted MRI to diagnose vestibular schwannoma and other relevant retrocochlear conditions was lower than for previous studies, which is likely to reflect trends in referral criteria. No single audiovestibular symptom or combination of symptoms is a statistically significant predictor of imaging outcome

2009-02-01

93

Diagnostic yield of MRI for audiovestibular dysfunction using contemporary referral criteria: correlation with presenting symptoms and impact on clinical management  

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Aim: To investigate the diagnostic yield of T2-weighted magnetic resonance imaging (MRI) screening for vestibular schwannoma and other relevant conditions in the setting of audiovestibular symptoms, given the more liberal contemporary referral criteria. To determine whether presenting clinical symptoms correlate with imaging outcome in order to guide future protocols for MRI referral. Materials and methods: Eight hundred and eighty-one consecutive MRI examinations performed in patients with audiovestibular dysfunction were reviewed. Clinical indications and findings were recorded. Case notes were reviewed in patients with positive imaging findings. Two-way, cross-tabulation, Chi-square analysis was performed to assess the relationship between presenting symptoms and imaging outcome. Results: Twelve of the 881 (1.4%) were positive for vestibular schwannoma. A further four of 881 (0.4%) revealed other relevant conditions. Incidental conditions, felt to be irrelevant to the presenting symptoms, were noted in 12 of the 881 (1.4%). In all 12 cases that were positive for vestibular schwannoma, either tinnitus or hearing loss was present. Conclusion: The yield for T2-weighted MRI to diagnose vestibular schwannoma and other relevant retrocochlear conditions was lower than for previous studies, which is likely to reflect trends in referral criteria. No single audiovestibular symptom or combination of symptoms is a statistically significant predictor of imaging outcome.

Vandervelde, C. [Department of Radiology, Guy' s and St Thomas' NHS Foundation Trust (United Kingdom)], E-mail: clivevandervelde@gmail.com; Connor, S.E.J. [Department of Radiology, Guy' s and St Thomas' NHS Foundation Trust (United Kingdom); Department of Neuroradiology, King' s College Hospital NHS Foundation Trust, London (United Kingdom)

2009-02-15

94

Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler memory scale-revised logical/verbal memory score for healthy subjects  

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Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM). T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A P value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant. Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal, T value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal, T value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found. To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing. (orig.)

Goto, Masami [University of Tokyo Hospital, Department of Radiological Technology, Graduate School of Medicine, Tokyo (Japan); Kanazawa University, Tsunomatyou, Graduate School of Medical Science, Kanazawa (Japan); Abe, Osamu; Takao, Hidemasa; Inano, Sachiko; Mori, Harushi; Kunimatsu, Akira; Ohtomo, Kuni [University of Tokyo Hospital, Department of Radiology, Tokyo (Japan); Miyati, Tosiaki [Kanazawa University, Tsunomatyou, Graduate School of Medical Science, Kanazawa (Japan); Yoshikawa, Takeharu; Hayashi, Naoto [University of Tokyo Hospital, Department of Computational Diagnostic Radiology and Preventive Medicine, Tokyo (Japan); Kabasawa, Hiroyuki [GE Healthcare, Japan Applied Science Laboratory, Hino (Japan); Aoki, Shigeki [Juntendo University, Department of Radiology, Tokyo (Japan); Ino, Kenji; Iida, Kyouhito; Yano, Keiichi [University of Tokyo Hospital, Department of Radiological Technology, Graduate School of Medicine, Tokyo (Japan)

2011-08-15

95

Correlation between mental health co?morbidity screening scores and clinical response in collaborative care treatment for depression  

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The hypothesis for this paper is that adult patients who have higher screening scores for mental health co?morbidities and depression have a greater likelihood of not responding to treatment with collaborative care management (CCM) for their depression within six months.

Angstman, Kurt B.; Dejesus, Ramona S.; Rohrer, James E.

2010-01-01

96

Do Standardized Tests Penalize Deep-Thinking, Creative, or Conscientious Students?: Some Personality Correlates of Graduate Record Examinations Test Scores  

Science.gov (United States)

The objective of the study reported here was to explore the relationship of Graduate Record Examinations (GRE) General Test scores to selected personality traits--conscientiousness, rationality, ingenuity, quickness, creativity, and depth. A sample of 342 GRE test takers completed short personality inventory scales for each trait. Analyses…

Powers, Donald E.; Kaufman, James C.

2004-01-01

97

CORRELATION OF PEMPHIGUS VULGARIS ANTIBODY TITERS BY INDIRECT IMMUNOFLUORESCENCE WITH ACTIVITY OF DISEASE BASED ON PEMPHIGUS AREA AND ACTIVITY SCORE (PAAS)  

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Indirect immunofluorescence (IIF) has been used to identify and measure autoantibody levels in pemphigus vulgaris but data about relationship between clinical severity of disease and antibody titers by IIF have been conflicting. We conducted this cross-sectional study to correlate the severity of oral and/or cutaneous involvement in patients with pemphigus vulgaris based on Pemphigus Area and Activity Score with IIF titers. Sixty-one new pemphigus vulgaris patients were included in this study...

Mortazavi, H.; Kiavash, K.; Chams-davatchi, N. Esmaili C.

2008-01-01

98

Apgar Scores  

Science.gov (United States)

... and Beyond > Apgar Scores Ages & Stages Listen Apgar Scores Article Body As soon as your baby is ... the womb. Each characteristic is given an individual score; two points for each of the five categories ...

99

Segmented corpus callosum diffusivity correlates with the Expanded Disability Status Scale score in the early stages of relapsing-remitting multiple sclerosis  

Science.gov (United States)

OBJECTIVE: The aim of this study was to characterize the microscopic damage to the corpus callosum in relapsing-remitting multiple sclerosis (RRMS) with diffusion tensor imaging and to investigate the correlation of this damage with disability. The diffusion tensor imaging parameters of fractional anisotropy and mean diffusivity provide information about the integrity of cell membranes, offering two more specific indices, namely the axial and radial diffusivities, which are useful for discriminating axon loss from demyelination. METHOD: Brain magnetic resonance imaging exams of 30 relapsing-remitting multiple sclerosis patients and 30 age- and sex-matched healthy controls were acquired in a 3T scanner. The axial diffusivities, radial diffusivities, fractional anisotropy, and mean diffusivity of five segments of the corpus callosum, correlated to the Expanded Disability Status Scale score, were obtained. RESULTS: All corpus callosum segments showed increased radial diffusivities and mean diffusivity, as well as decreased fractional anisotropy, in the relapsing-remitting multiple sclerosis group. The axial diffusivity was increased in the posterior midbody and splenium. The Expanded Disability Status Scale scores correlated more strongly with axial diffusivities and mean diffusivity, with an isolated correlation with radial diffusivities in the posterior midbody of the corpus callosum. There was no significant correlation with lesion loads. CONCLUSION: Neurological dysfunction in relapsing-remitting multiple sclerosis can be influenced by commissural disconnection, and the diffusion indices of diffusion tensor imaging are potential biomarkers of disability that can be assessed during follow-up.

de Medeiros Rimkus, Carolina; de Faria Junqueira, Thiago; Callegaro, Dagoberto; Otaduy, Maria Concepcion Garcia; da Costa Leite, Claudia

2013-01-01

100

Changes in allergy symptoms and depression scores are positively correlated in patients with recurrent mood disorders exposed to seasonal peaks in aeroallergens.  

Science.gov (United States)

Although growing evidence supports an association between allergy, allergens and depression, it remains unknown if this relationship is between "states" (possible triggers) or "traits" (possible vulnerabilities). We hypothesized that patients with recurrent mood disorders who are sensitized to tree pollen (as determined by allergen specific IgE antibodies), in comparison to those who are not sensitized, would report larger negative changes in mood during exposure to tree pollen in spring. We also hypothesized that differences between high and low tree pollen periods in self reported allergy symptoms would correlate positively with differences in self reported depression scores. We present 1-year preliminary data on the first 51 patients with unipolar or bipolar disorder (age: 19-63 years, 65% female, twelve patients were tree-pollen IgE positive). Ratings of mood and allergic disease status were performed once during the peak airborne pollen counts and once during the period of low airborne pollen counts, as reported by two local pollen counting stations. Linear regression models were developed to examine associations of changes in depression scores (dependent variable) with tree pollen sensitization, changes in the allergy symptom severity score, adjusted for gender and order of testing. We did not confirm the hypothesized relationship between a specific tree pollen sensitization and changes in mood during tree pollen exposure. We did confirm the hypothesized positive relationship between the changes in allergy symptoms and changes in subjects' depression scores (adjusted ptree pollen. A relationship between changes in allergy symptom scores and changes in depression scores supports a state-level rather than only trait-level relationship, and thus lends optimism to future causality-testing interventional studies, which might then lead to novel preventative environmental interventions in mood disorders. PMID:18167612

Postolache, Teodor T; Lapidus, Manana; Sander, Evan R; Langenberg, Patricia; Hamilton, Robert G; Soriano, Joseph J; McDonald, Jessica S; Furst, Nancy; Bai, Jie; Scrandis, Debra A; Cabassa, Johanna A; Stiller, John W; Balis, Theodora; Guzman, Alvaro; Togias, Alkis; Tonelli, Leonardo H

2007-01-01

 
 
 
 
101

Correlações genéticas entre escores visuais e características reprodutivas em bovinos Nelore usando inferência bayesiana Genetic correlations between visual scores and reproductive traits in Nelore cattle using Bayesian inference  

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Full Text Available O objetivo deste trabalho foi estimar a herdabilidade e as correlações genéticas entre escores visuais e características reprodutivas de animais da raça Nelore. As características avaliadas foram: precocidade, musculatura, e escores de conformação à desmama (PD, MD e CD, respectivamente e ao sobreano (PS, MS e CS, respectivamente; idade ao primeiro parto (IPP; e perímetro escrotal (PE. Foram utilizadas informações de 66.244 animais, nascidos entre 1990 e 2006. Os parâmetros genéticos foram estimados em análises bicaracterísticas, com inferência bayesiana. Foi utilizado um modelo linear para IPP e PE, e um modelo não linear ("threshold" para os escores visuais. As herdabilidades estimadas foram: CD, 0,19±0,02; PD, 0,23±0,02; MD, 0,20±0,02; CS, 0,26±0,01; PS, 0,33±0,02; MS, 0,32±0,02; IPP, 0,16±0,03; e PE, 0,36±0,02. As correlações genéticas estimadas entre os escores visuais e IPP foram negativas, de -0,18±0,03 a -0,29±0,02. Correlações genéticas positivas foram obtidas entre os escores visuais e o PE, de 0,19±0,01 a 0,31±0,01. A seleção de animais com os maiores escores visuais, principalmente ao sobreano, permite melhorar o desempenho reprodutivo dos rebanhosThe aim of this work was to estimate the heritability and the genetic correlations between visual scores and reproductive traits of Nelore cattle. The traits evaluated were: finishing, muscling, and conformation scores at weaning (PD, MD, and CD, respectively and yearling (PS, MS and CS, respectively; age at the first calving (IPP and scrotal circumference (PE. The records of 66,244 animals born between 1990 and 2006 were used. The genetic parameters were estimated using bi-trait animal analyses with Bayesian inference. A linear model for IPP and PE and a nonlinear (threshold model for visual scores were used. The heritability estimates were: CD, 0.19±0.02; PD, 0.23±0.02; MD, 0.20±0.02; CS, 0.26±0.01; PS, 0.33±0.02; MS, 0.32±0.02; IPP, 0.16±0.03; and PE, 0.36±0.02. Genetic correlation estimates between visual scores and IPP were negative, varying from -0.18±0.03 to -0.29±0.02. Positive genetic correlations were obtained between the visual scores and PE, from 0.19±0.01 to 0.31±0.01. Animal selection with the highest visual scores, mainly those taken after the yearling age, allows to improve herd reproductive traits

Arione Augusti Boligon

2010-12-01

102

CT findings score for differentiating adrenal tumours in patients with extra-adrenal malignomas  

International Nuclear Information System (INIS)

Purpose: In a retrospective study the diagnostic accuracy of computed tomography for the differentiation of benign from malignant adrenal masses in patients with extra-adrenal malignancies was evaluated. For this differentiation a new score system was tested. Patients and methods: Size, density, structure, and borders of adrenal masses in 60 patients with extra-adrenal tumours were analysed and scored. The single criteria and the total score values were correlated with the final diagnosis achieved either by histology or by follow-up CT examinations. Results: Score values above 4 indicated always metastases and score values below 2 were benign lesions. An overlap occurred at score values between 2 and 3 resulting in an overall accuracy of 83,3%. Conclusion: Single CT criteria are not reliable enough to differentiate benign from malignant adrenal lesions; better results are achieved by using our scoring system. (orig.)

1996-08-01

103

Fetal bone age revisited: proposal of a new radiographic score  

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In order to establish a fetal bone age score, the post-mortem skeletal radiographs of 85 selected normal fetuses aged from 15 to 41 weeks of gestation (WG) were analysed. Twenty-eight skeletal areas were selected for which quantitative and/or qualitative criteria were defined. Each new aspect was graded and statistically tested by the stepwise linear regression method. Two modalities of scores of decreasing complexity were then designed. The use of these two scores permitted the assessment of the fetal age with r{sup 2} values of 0.97 and 0.96 (standard error of estimation of 1.19 and 1.36 WG). Applied to 15 intrauterine growth retardation (IUGR) fetuses, the age estimated by these scores was well correlated with the age obtained by extraosseous criteria of maturation. This method is proposed as a tool for determining the fetal age during necropsy and could also be useful in US prenatal evaluation. (orig.)

Stempfle, N. [Dept. of Radiology, R. Debre Hospital, 75 - Paris (France); Huten, Y. [Dept. of Developmental Biology, R. Debre Hospital, 75 - Paris (France); Fondacci, C. [Dept. of Developmental Biology, R. Debre Hospital, 75 - Paris (France); Lang, T. [Dept. of Statistics, Univ. of Pitie-Salpetriere, 75 - Paris (France); Hassan, T. [Dept. of Radiology, R. Debre Hospital, 75 - Paris (France); Nessmann, C. [Dept. of Developmental Biology, R. Debre Hospital, 75 - Paris (France)

1995-09-01

104

Analysis of genetic correlations between multivariate measures of lactation persistency and somatic cell score in Italian Simmental cattle  

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Genetic relationships between lactation curve traits and Somatic Cell Count are of great interest for dairy cattle breeding. Factor Analysis (MFA) and Principal Component Analysis (PCA) can be used to extract from the correlation matrix of milk test day records new unobservable (latent) variables that can be related to lactation curve shape. Previous researches report that MFA is particularly able to extract two latent variables related with level of production in early lactation ...

Vicario, Daniele; Steri, Roberto; Cappio Borlino, Aldo; Macciotta, Nicolo? Pietro Paolo

2007-01-01

105

Correlações genéticas entre escores visuais e características reprodutivas em bovinos Nelore usando inferência bayesiana / Genetic correlations between visual scores and reproductive traits in Nelore cattle using Bayesian inference  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O objetivo deste trabalho foi estimar a herdabilidade e as correlações genéticas entre escores visuais e características reprodutivas de animais da raça Nelore. As características avaliadas foram: precocidade, musculatura, e escores de conformação à desmama (PD, MD e CD, respectivamente) e ao sobrea [...] no (PS, MS e CS, respectivamente); idade ao primeiro parto (IPP); e perímetro escrotal (PE). Foram utilizadas informações de 66.244 animais, nascidos entre 1990 e 2006. Os parâmetros genéticos foram estimados em análises bicaracterísticas, com inferência bayesiana. Foi utilizado um modelo linear para IPP e PE, e um modelo não linear ("threshold") para os escores visuais. As herdabilidades estimadas foram: CD, 0,19±0,02; PD, 0,23±0,02; MD, 0,20±0,02; CS, 0,26±0,01; PS, 0,33±0,02; MS, 0,32±0,02; IPP, 0,16±0,03; e PE, 0,36±0,02. As correlações genéticas estimadas entre os escores visuais e IPP foram negativas, de -0,18±0,03 a -0,29±0,02. Correlações genéticas positivas foram obtidas entre os escores visuais e o PE, de 0,19±0,01 a 0,31±0,01. A seleção de animais com os maiores escores visuais, principalmente ao sobreano, permite melhorar o desempenho reprodutivo dos rebanhos Abstract in english The aim of this work was to estimate the heritability and the genetic correlations between visual scores and reproductive traits of Nelore cattle. The traits evaluated were: finishing, muscling, and conformation scores at weaning (PD, MD, and CD, respectively) and yearling (PS, MS and CS, respective [...] ly); age at the first calving (IPP) and scrotal circumference (PE). The records of 66,244 animals born between 1990 and 2006 were used. The genetic parameters were estimated using bi-trait animal analyses with Bayesian inference. A linear model for IPP and PE and a nonlinear (threshold) model for visual scores were used. The heritability estimates were: CD, 0.19±0.02; PD, 0.23±0.02; MD, 0.20±0.02; CS, 0.26±0.01; PS, 0.33±0.02; MS, 0.32±0.02; IPP, 0.16±0.03; and PE, 0.36±0.02. Genetic correlation estimates between visual scores and IPP were negative, varying from -0.18±0.03 to -0.29±0.02. Positive genetic correlations were obtained between the visual scores and PE, from 0.19±0.01 to 0.31±0.01. Animal selection with the highest visual scores, mainly those taken after the yearling age, allows to improve herd reproductive traits

Arione Augusti, Boligon; Lucia Galvão de, Albuquerque.

106

Assessment of the metabolic flow phenotype of primary colorectal cancer: correlations with microvessel density are influenced by the histological scoring method  

Energy Technology Data Exchange (ETDEWEB)

To investigate how the histological scoring of microvessel density affects correlations between integrated {sup 18}F-FDG-PET/perfusion CT parameters and CD105 microvessel density. A total of 53 patients were enrolled from 2007 to 2010. Integrated {sup 18}F-FDG-PET/perfusion CT was successful in 45 patients, 35 of whom underwent surgery without intervening treatment. Tumour SUV{sub max}, SUV{sub mean} and regional blood flow (BF) were derived. Immunohistochemical staining for CD105 expression and analysis were performed for two hot spots, four hot spots and the Chalkley method. Correlations between metabolic flow parameters and CD105 expression were assessed using Spearman's rank correlation. Mean (SD) for tumour size was 38.5 (20.5) mm, for SUV{sub max}, SUV{sub mean} and BF it was 19.1 (4.5), 11.6 (2.5) and 85.4 (40.3) mL/min/100 g tissue, and for CD105 microvessel density it was 71.4 (23.6), 66.8 (22.9) and 6.18 (2.07) for two hot spots, four hot spots and the Chalkley method, respectively. Positive correlation between BF and CD105 expression was modest but higher for Chalkley than for four hot spots analysis (r = 0.38, P = 0.03; r = 0.33, P = 0.05, respectively). There were no significant correlations between metabolic parameters (SUV{sub max} or SUV{sub mean}) and CD105 expression (r = 0.08-0.22, P = 0.21-0.63). The histological analysis method affects correlations between tumour CD105 expression and BF but not SUV{sub max} or SUV{sub mean}. (orig.)

Goh, Vicky [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Rodriguez-Justo, Manuel [University College Hospital, Department of Histopathology, London (United Kingdom); Engledow, Alec; Peck, Jacqui [University College Hospital, Department of Surgery, London (United Kingdom); Shastry, Manu; Endozo, Raymondo; Meagher, Marie; Groves, Ashley M. [University College Hospital, Institute of Nuclear Medicine, London (United Kingdom); Taylor, Stuart A.; Halligan, Steve [University College Hospital, Specialist Radiology, London (United Kingdom)

2012-08-15

107

Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients  

Directory of Open Access Journals (Sweden)

Full Text Available Vasileios Peppes, George Rammos, Efstathios Manios, Eleni Koroboki, Stylianos Rokas, Nikolaos ZakopoulosDepartment of Clinical Therapeutics, Alexandra Hospital, University of Athens School of Medicine, Athens, GreeceBackground: Our objective was to associate serum levels of myocardial enzymes and inflammatory biomarkers with severity of coronary artery disease (CAD.Patients and methods: 123 patients participated in our study, including 65 cases of acute myocardial infarction (MI, 27 cases of newly diagnosed CAD – without MI – and 31 controls. In all subjects, myocardial serum enzyme levels (creatine phosphokinase, aspartate aminotransferase, lactate dehydrogenase and inflammatory indices (C-reactive protein, fibrinogen, white blood cells, and erythrocyte sedimentation rate were measured. Patients were all submitted to coronary angiography and CAD severity was evaluated by Gensini score.Results: Significant differences concerning enzyme serum levels and inflammatory indices were found to exist between the three study groups, being highest among patients with acute MI (p < 0.001. A significant  association was demonstrated between Gensini score and serum enzyme levels as well as inflammatory biomarkers.Conclusions: Our findings suggest that serum levels of myocardial enzymes and inflammatory indices correlate with CAD severity in Greek patients.Keywords: myocardial enzymes, inflammation, coronary angiography, coronary artery disease

Vasileios Peppes

2008-08-01

108

Value of CT and clinical criteria in assessment of patients with acute pancreatitis  

International Nuclear Information System (INIS)

Objective: To re-assess the value of CT and clinical criteria as prognostic and severity indicators in acute pancreatitis and the correlation between them. Methods: Sixty-five cases with acute pancreatitis (AP) were included in the study. The hospitalization days, fevering days and overall complications were regarded as clinical endpoints for the patient group. CT criteria used for AP evaluation included Balthazar's plain CT scan score, CT severity index (CTSI) and London's pancreatic size index (PSI) score. Clinical criteria was Ranson score. The correlations between each criterion and the clinical endpoints, and the relation between CT and clinical criteria were analyzed. The power of each criterion and combination of CT and clinical criteria in predicting overall complications of AP were assessed and compared by using a receiver operative characteristic curve (ROC) analysis. Results: The mean scores of PSI, Ranson among the three groups classified according to overall complications were significantly different. Except Balthazar's plain CT scan criterion, each criterion's mean score in-groups with local complications was significantly higher than that in-group without. The overall complications were significantly more in severe group than that in mild group classified according to each criterion except plain CT scan criterion. Mean days of hospital stay and fevering were significantly longer in severe group with Ranson score than that in mild group. PSI and Ranson score had a linear correlation with fevering days, and Ranson score had a linear correlation with hospitalization days. In CT criteria, only PSI had a linear correlation with Ranson score. The findings of plain CT scan was found to be some laggard compared with that of clinic. ROC analysis showed the largest A Z of Ranson score, and there was no A Z increase when CT criteria were added to clinical criteria. Conclusion: The predictive values of Ranson and PSI score in AP patients are superior to that of other criteria. CT criteria are superior to clinical criterion in predicting local complications, and short-term CT follow-up examination is important in the evaluation of AP

2006-01-01

109

Value of CT and clinical criteria in assessment of patients with acute pancreatitis  

Energy Technology Data Exchange (ETDEWEB)

Objective: To re-assess the value of CT and clinical criteria as prognostic and severity indicators in acute pancreatitis and the correlation between them. Methods: Sixty-five cases with acute pancreatitis (AP) were included in the study. The hospitalization days, fevering days and overall complications were regarded as clinical endpoints for the patient group. CT criteria used for AP evaluation included Balthazar's plain CT scan score, CT severity index (CTSI) and London's pancreatic size index (PSI) score. Clinical criteria was Ranson score. The correlations between each criterion and the clinical endpoints, and the relation between CT and clinical criteria were analyzed. The power of each criterion and combination of CT and clinical criteria in predicting overall complications of AP were assessed and compared by using a receiver operative characteristic curve (ROC) analysis. Results: The mean scores of PSI, Ranson among the three groups classified according to overall complications were significantly different. Except Balthazar's plain CT scan criterion, each criterion's mean score in-groups with local complications was significantly higher than that in-group without. The overall complications were significantly more in severe group than that in mild group classified according to each criterion except plain CT scan criterion. Mean days of hospital stay and fevering were significantly longer in severe group with Ranson score than that in mild group. PSI and Ranson score had a linear correlation with fevering days, and Ranson score had a linear correlation with hospitalization days. In CT criteria, only PSI had a linear correlation with Ranson score. The findings of plain CT scan was found to be some laggard compared with that of clinic. ROC analysis showed the largest A {sub Z} of Ranson score, and there was no A {sub Z} increase when CT criteria were added to clinical criteria. Conclusion: The predictive values of Ranson and PSI score in AP patients are superior to that of other criteria. CT criteria are superior to clinical criterion in predicting local complications, and short-term CT follow-up examination is important in the evaluation of AP.

Ju Shenghong [Department of Radiology, Zhongda Hospital, Southeast University, 87 Ding Jia Qiao, Nanjing 210009 (China); Chen Feng [Department of Radiology, Zhongda Hospital, Southeast University, 87 Ding Jia Qiao, Nanjing 210009 (China)]. E-mail: chenfengbe@yahoo.com.cn; Liu Shengli [Department of Radiology, Zhongda Hospital, Southeast University, 87 Ding Jia Qiao, Nanjing 210009 (China); Zheng Kaier [Department of Radiology, Zhongda Hospital, Southeast University, 87 Ding Jia Qiao, Nanjing 210009 (China); Teng Gaojun [Department of Radiology, Zhongda Hospital, Southeast University, 87 Ding Jia Qiao, Nanjing 210009 (China)

2006-01-15

110

Tolerant or intolerant character of interacting criteria in aggregation by the Choquet integral  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In many multi-criteria decision-making problems the decision criteria present some interaction whose nature may vary from one situation to another. For example, some criteria may be statistically correlated, thus making them somewhat redundant or opposed. Some others may be somewhat substitutive or complementary depending on the behavior of the decision maker. Some others may be decisive in the sense that the global score (of any alternative) obtained by aggregation is bounded by the partial ...

Marichal, Jean-luc

2004-01-01

111

Score 2009  

Science.gov (United States)

Objectives/Purpose: The SCORE 2009 workshop has been conducted annually for the past eight years. This workshop brings together key program personnel and site coordinators, research nurses, data managers, and quality assurance officers from institutions

112

Contact allergy to nickel: patch test score correlates with IL-5, but not with IFN-gamma nickel-specific secretion by peripheral blood lymphocytes.  

Science.gov (United States)

Traditionally, allergic contact dermatitis (ACD) has been associated with the activity of Th1 lymphocytes that secrete interferon gamma. Recent evidence indicates that other cells, e.g. interleukin 5 (IL-5)-secreting Th2 or Tc2 cells may be among the key effectors of ACD. The aim of the present study was to assess the influence of nickel-specific IFN-gamma secretion (marker of Th1 and Tc1 activity) and IL-5 secretion (Th2 and Tc2) on the clinical outcome (patch test score) in nickel-allergic patients. 40 women with suspicion of ACD were involved, aged from 14-54 (median 31.5) years. They were patch tested with NiSO(4). Peripheral blood mononuclear cells (PBMC) from the patients were cultured and analysed for IFN-gamma and IL-5 secretion in response to NiSO(4). A series of statistical models (classical logit or cloglog link function) were used. We demonstrate that nickel-specific IL-5 secretion by PBMC is correlated with the intensity of patch test reaction (p=0.05), with no significant effect of IFN-gamma. An increase in the nickel-specific IL-5 secretion from PBMC by 10 pg/ml is associated with a 10-20% increase (depending on statistical model) in the odds ratio of the patient to have a higher patch test score. These findings support the assumption that cells secreting IL-5 (e.g. Th2, Tc2) play a more important role in the pathogenesis of ACD than previously thought. PMID:19572476

Czarnobilska, Ewa; Jenner, Bartosz; Kaszuba-Zwoinska, Jolanta; Kapusta, Maria; Obtu?owicz, Krystyna; Thor, Piotr; Spiewak, Rados?aw

2009-06-01

113

Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70  

Directory of Open Access Journals (Sweden)

Full Text Available Michelle E Orme,1 Katherine S MacGilchrist,2 Stephen Mitchell,2 Dean Spurden,3 Alex Bird31Icera Consulting, Swindon, Wiltshire, UK; 2Systematic Review Department, Abacus International, Bicester, Oxfordshire, UK; 3Pfizer UK Limited, Tadworth, Surrey, UKBackground: Biologic disease-modifying antirheumatic drugs (bDMARDs extend the treatment choices for rheumatoid arthritis patients with suboptimal response or intolerance to conventional DMARDs. The objective of this systematic review and meta-analysis was to compare the relative efficacy of EU-licensed bDMARD combination therapy or monotherapy for patients intolerant of or contraindicated to continued methotrexate.Methods: Comprehensive, structured literature searches were conducted in Medline, Embase, and the Cochrane Library, as well as hand-searching of conference proceedings and reference lists. Phase II or III randomized controlled trials reporting American College of Rheumatology (ACR criteria scores of 20, 50, and 70 between 12 and 30 weeks' follow-up and enrolling adult patients meeting ACR classification criteria for rheumatoid arthritis previously treated with and with an inadequate response to conventional DMARDs were eligible. To estimate the relative efficacy of treatments whilst preserving the randomized comparisons within each trial, a Bayesian network meta-analysis was conducted in WinBUGS using fixed and random-effects, logit-link models fitted to the binomial ACR 20/50/70 trial data.Results: The systematic review identified 10,625 citations, and after a review of 2450 full-text papers, there were 29 and 14 eligible studies for the combination and monotherapy meta-analyses, respectively. In the combination analysis, all licensed bDMARD combinations had significantly higher odds of ACR 20/50/70 compared to DMARDs alone, except for the rituximab comparison, which did not reach significance for the ACR 70 outcome (based on the 95% credible interval. The etanercept combination was significantly better than the tumor necrosis factor-? inhibitors adalimumab and infliximab in improving ACR 20/50/70 outcomes, with no significant differences between the etanercept combination and certolizumab pegol or tocilizumab. Licensed-dose etanercept, adalimumab, and tocilizumab monotherapy were significantly better than placebo in improving ACR 20/50/70 outcomes. Sensitivity analysis indicated that including studies outside the target population could affect the results.Conclusion: Licensed bDMARDs are efficacious in patients with an inadequate response to conventional therapy, but tumor necrosis factor-? inhibitor combination therapies are not equally effective.Keywords: bDMARD, rheumatoid arthritis, etanercept, systematic review, network meta-analysis, comparative effectiveness

Orme ME

2012-12-01

114

Walk Score  

Science.gov (United States)

If you're looking for a walkable community, is there a way to determine which neighborhood might be best for you? Interested parties might use the Walk Score to get a basic sense of nearby amenities, such as grocery stores, parks, restaurants, and so on. Visitors can type in a street address or neighborhood, and they can find out the location's cumulative Walk Score. Also, visitors can use the site to find out about potential nearby rental properties, if they are so inclined. This site is compatible with all operating systems.

2012-04-27

115

Insulin-like growth factor II mRNA binding protein 3 (IMP3 is overexpressed in prostate cancer and correlates with higher Gleason scores  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3 is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Methods Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC. IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. Results IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p Conclusions Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed.

Mortezavi Ashkan

2010-06-01

116

Acetabulum protrusio and center edge angle: new MR-imaging measurement criteria - a correlative study with measurement derived from conventional radiography  

International Nuclear Information System (INIS)

The goal of this study was to identify a method of measurement for acetabulum protrusio and center edge angle (CEA) using MR imaging of the pelvis that correlated with classic methods using radiographic landmarks. MR images and radiographs of the pelvis in 67 patients (132 hips) were used to identify reliable MR-imaging methods for measuring protrusio acetabulum and CEA that correlated strongly with established radiographic measurements. Protrusio acetabulum was determined using the radiographic criterion that the acetabular line projects medial to the ilioischial line by 3 mm or more in men and 6 mm or more in women. Pearson correlation factor was used to determine inter-observer variability and those methods that demonstrated the strongest correlation. The mean and standard deviation of MR-imaging and radiographic measurements for both the normal and protrusio hips were established. Several MR methods correlated strongly with radiographic measurements. The preferred method employed axial MR images at the level of the ischial spine with measurement of the distance between the medial most point of the acetabular fossa and a line perpendicular to the horizontal axis that passed through the lateral margin of the posterior inner pelvic wall. The Pearson's correlation factor between radiographic and MR measurements using this method was 0.84, and inter-observer correlation was 0.80. There were 126 hips in 63 patients (17 female and 44 male) that did not meet the radiographic criteria for protrusio acetabula. In this group of normal hips, the mean and standard deviation of radiographic measurements were 1.9 and 2.8 mm in male patients and -0.5 and 1.7 mm in female patients, and the mean and standard deviation for the preferred MR method was 1.3 and 2.5 mm in male patients and -0.8 and 1.9 mm in female patients. A total of six hips in four patients (two female and two male) met the radiographic criteria for protrusio acetabula. In this group of patients, the mean and standard deviation of radiographic measurements were -3.7 and 1 mm in male patients and -5.4 and 0.9 mm in female patients, and the mean and standard deviation for the preferred MR method was -4.1 and 0.4 mm in male patients and -6.5 and 0.3 mm in female patients. Our study also showed that the CEA was best measured using anterior to middle coronal MR images. Posterior coronal MR-imaging measurements correlated poorly with radiographic measurements. MR imaging can be used to assess acetabular morphology and measure acetabulum protrusio. (orig.)

2009-02-01

117

Acetabulum protrusio and center edge angle: new MR-imaging measurement criteria - a correlative study with measurement derived from conventional radiography  

Energy Technology Data Exchange (ETDEWEB)

The goal of this study was to identify a method of measurement for acetabulum protrusio and center edge angle (CEA) using MR imaging of the pelvis that correlated with classic methods using radiographic landmarks. MR images and radiographs of the pelvis in 67 patients (132 hips) were used to identify reliable MR-imaging methods for measuring protrusio acetabulum and CEA that correlated strongly with established radiographic measurements. Protrusio acetabulum was determined using the radiographic criterion that the acetabular line projects medial to the ilioischial line by 3 mm or more in men and 6 mm or more in women. Pearson correlation factor was used to determine inter-observer variability and those methods that demonstrated the strongest correlation. The mean and standard deviation of MR-imaging and radiographic measurements for both the normal and protrusio hips were established. Several MR methods correlated strongly with radiographic measurements. The preferred method employed axial MR images at the level of the ischial spine with measurement of the distance between the medial most point of the acetabular fossa and a line perpendicular to the horizontal axis that passed through the lateral margin of the posterior inner pelvic wall. The Pearson's correlation factor between radiographic and MR measurements using this method was 0.84, and inter-observer correlation was 0.80. There were 126 hips in 63 patients (17 female and 44 male) that did not meet the radiographic criteria for protrusio acetabula. In this group of normal hips, the mean and standard deviation of radiographic measurements were 1.9 and 2.8 mm in male patients and -0.5 and 1.7 mm in female patients, and the mean and standard deviation for the preferred MR method was 1.3 and 2.5 mm in male patients and -0.8 and 1.9 mm in female patients. A total of six hips in four patients (two female and two male) met the radiographic criteria for protrusio acetabula. In this group of patients, the mean and standard deviation of radiographic measurements were -3.7 and 1 mm in male patients and -5.4 and 0.9 mm in female patients, and the mean and standard deviation for the preferred MR method was -4.1 and 0.4 mm in male patients and -6.5 and 0.3 mm in female patients. Our study also showed that the CEA was best measured using anterior to middle coronal MR images. Posterior coronal MR-imaging measurements correlated poorly with radiographic measurements. MR imaging can be used to assess acetabular morphology and measure acetabulum protrusio. (orig.)

Chen, Lina; Resnick, Donald [VASDHS-Radiology, San Diego, CA (United States); UCSD Medical Center, San Diego, CA (United States); Boonthathip, Mayura; Cardoso, Fabiano; Clopton, Paul [VASDHS-Radiology, San Diego, CA (United States)

2009-02-15

118

Keeping Score  

Science.gov (United States)

Conductor Michael Tilson Thomas has embarked on a number of intriguing and worthy projects during his career, including a series of ambitious recordings with the San Francisco Symphony and a number of well-received concerts with the late Sarah Vaughan in the 1980s. Most recently, he has teamed up with PBS (and his colleagues in the San Francisco Symphony) to create the âÂÂKeeping Score: Revolutions in Musicâ television series. Visitors to this site can explore the very fine multimedia presentations that are meant to accompany and enhance the entire educational and aesthetic experience of the television programs. Currently, there are multimedia profiles of StravinskyâÂÂs âÂÂRite of SpringâÂÂ, BeethovenâÂÂs âÂÂEroicaâ Symphony and the development of CoplandâÂÂs approach to creating an âÂÂAmericanâ sound. Each site features a brief introduction by Thomas, and then visitors are invited into the score to follow along as the piece progresses. In the top left-hand corner of the score, visitors can watch Thomas as he conducts. Overall, the experience of this website is stimulating and edifying, without being visually (or aurally) overwhelming.

119

Correlação dos escores de risco com a anatomia coronária na síndrome coronária aguda sem supra-ST / Correlation of risk scores with coronary anatomy in non-ST-elevation acute coronary syndrome  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTO:Há poucas publicações sobre a correlação entre escores de risco e anatomia coronária na síndrome coronária aguda (SCA). OBJETIVO: Correlacionar os escores de risco com a gravidade da lesão coronária na SCA sem supra-ST. MÉTODOS: Foram analisados 582 pacientes entre julho de 2004 e outubro [...] de 2006. Avaliou-se a correlação entre os escores de risco TIMI, GRACE hospitalar e em seis meses com lesão coronária > 50%, por método não paramétrico de Spearman. Modelo de regressão logística múltipla foi realizado para determinar a habilidade preditiva dos escores em discriminar quem terá ou não lesão coronária > 50%. RESULTADOS: Foram 319 (54,8%) homens e a média de idade era 59,9 (± 10,6) anos. Correlação positiva foi observada entre a pontuação dos escores de risco e lesão coronária > 50% (escore de risco TIMI r = 0,363 [p 50% foi: TIMI = 0,704 [IC95% 0,656-0,752; p Abstract in english BACKGROUND: The literature lacks studies regarding the correlation between risk scores and coronary anatomy in acute coronary syndrome (ACS) OBJECTIVE: Correlate risk scores with the severity of the coronary lesion in ACS with non-ST elevation. METHODS: A total of 582 patients were analyzed between [...] July 2004 and October 2006. The correlation between TIMI risk scores and GRACE (hospital and six months) scores was performed for patients with coronary lesion > 50%, using Spearman´s non-parametric method. Multiple regression logistics was used to determine the predictive ability of the scores to discriminate to discriminate who will have a coronary lesion > 50%. RESULTS: Most subjects were male (319 or 54.8%), mean age of 59.9 (± 10.6) years. A positive correlation was observed between risk scores and >coronary lesion > 50% (TIMI r = 0.363 [p 50% was: TIMI = 0.704 [CI95% 0.656-0.752; p

Elizabete Silva dos, Santos; Luciano de Figueiredo, Aguiar Filho; Daniela Menezes, Fonseca; Hugo José, Londero; Rogério Martins, Xavier; Marcos Paulo, Pereira; Luiz, Minuzzo; Roberta de, Souza; Ari, Timerman.

120

The Influence of Therapist Variance on the Dependability of Therapists' Alliance Scores: A Brief Comment on "The Dependability of Alliance Assessments: The Alliance-Outcome Correlation Is Larger than You Think" (Crits-Christoph et al., 2011)  

Science.gov (United States)

Objective: Crits-Christoph, Connolly Gibbons, Hamilton, Ring-Kurtz, and Gallop (2011) used generalizability theory to critique the measurement of the therapeutic alliance in psychotherapy research, showing that the dependability of alliance scores may be quite low, which in turn can lead to attenuated alliance-outcome correlation estimates. Method…

Baldwin, Scott A.; Imel, Zac E.; Atkins, David C.

2012-01-01

 
 
 
 
121

Correlação dos escores de risco com a anatomia coronária na síndrome coronária aguda sem supra-ST Correlation of risk scores with coronary anatomy in non-ST-elevation acute coronary syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available FUNDAMENTO:Há poucas publicações sobre a correlação entre escores de risco e anatomia coronária na síndrome coronária aguda (SCA. OBJETIVO: Correlacionar os escores de risco com a gravidade da lesão coronária na SCA sem supra-ST. MÉTODOS: Foram analisados 582 pacientes entre julho de 2004 e outubro de 2006. Avaliou-se a correlação entre os escores de risco TIMI, GRACE hospitalar e em seis meses com lesão coronária > 50%, por método não paramétrico de Spearman. Modelo de regressão logística múltipla foi realizado para determinar a habilidade preditiva dos escores em discriminar quem terá ou não lesão coronária > 50%. RESULTADOS: Foram 319 (54,8% homens e a média de idade era 59,9 (± 10,6 anos. Correlação positiva foi observada entre a pontuação dos escores de risco e lesão coronária > 50% (escore de risco TIMI r = 0,363 [p 50% foi: TIMI = 0,704 [IC95% 0,656-0,752; p BACKGROUND: The literature lacks studies regarding the correlation between risk scores and coronary anatomy in acute coronary syndrome (ACS OBJECTIVE: Correlate risk scores with the severity of the coronary lesion in ACS with non-ST elevation. METHODS: A total of 582 patients were analyzed between July 2004 and October 2006. The correlation between TIMI risk scores and GRACE (hospital and six months scores was performed for patients with coronary lesion > 50%, using Spearman´s non-parametric method. Multiple regression logistics was used to determine the predictive ability of the scores to discriminate to discriminate who will have a coronary lesion > 50%. RESULTS: Most subjects were male (319 or 54.8%, mean age of 59.9 (± 10.6 years. A positive correlation was observed between risk scores and >coronary lesion > 50% (TIMI r = 0.363 [p 50% was: TIMI = 0.704 [CI95% 0.656-0.752; p <0.0001]; hospital GRACE = 0.623 [CI95% 0.573-0.673; p < 0.0001]; GRACE at six months= 0.562 [CI95% 0.510-0.613; p ;= 0.0255]. Comparing the areas under the ROC curve, it was found: TIMI versus hospital GRACE: p = 0.01; TIMI versus GRACE at six months:p < 0.0001; hospital GRACE versus GRACE at six months: p = 0.0461. CONCLUSION: Risk scores correlate with the severity of coronary lesions, and the TIMI risk score showed the best predictive ability.

Elizabete Silva dos Santos

2013-01-01

122

[Prognostic scores in peritonitis: the Mannheim Peritonitis Index or APACHE II?].  

Science.gov (United States)

Scoring systems are mandatory to quantify the severity of abdominal sepsis on the basis of objective criteria. The Mannheim Peritonitis Index (MPI) is a disease-specific score based on easy to handle clinical parameters. APACHE II is a large-scale general scoring system with acute physiological and chronic health parameters. To evaluate the prognostic value of both systems 108 patients with severe abdominal infection managed by open treatment entered a prospective study. 32 patients (29.6%) died, 23 of them due to sepsis and 9 from other causes. Both MPI and APACHE II scores correlated closely with mortality, with three and two significantly different classes, respectively. Statistical validation showed a sensitivity of 93% and a specificity of 16% for MPI, and 89% and 25% for the APACHE II. ROC curves were nearly parallel for both scores. In conclusion there was no significant difference in prognostic value between the scoring systems. PMID:7845160

Demmel, N; Muth, G; Maag, K; Osterholzer, G

1994-01-01

123

Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy--a single centre, open-label study.  

LENUS (Irish Health Repository)

With the development of increasing numbers of potential therapeutic agents in inflammatory disease comes the need for effective biomarkers to help screen for drug efficacy and optimal dosing regimens early in the clinical trial process. This need has been recognized by the Outcome Measures in Rheumatology Clinical Trials (OMERACT) group, which has established guidelines for biomarker validation. To seek a candidate synovial biomarker of treatment response in psoriatic arthritis (PsA), we determined whether changes in immunohistochemical markers of synovial inflammation correlate with changes in disease activity scores assessing 28 joints (?DAS28) or magnetic resonance imaging synovitis scores (?MRI) in patients with PsA treated with a biologic agent.

Pontifex, Eliza K

2011-01-01

124

Correlation between leachate production and construction-operation criteria of MSW landfills; Correlazione tra la produzione di percolato e le caratteristiche costruttive e gestionali di discariche per RSU  

Energy Technology Data Exchange (ETDEWEB)

This research (which is still going on) is aimed to collect and analyse monitoring of several MSW (Municipal Solid Wastes) landfills, in order to point out possible correlations among design-construction and operation criteria and the characteristics of landfill emissions. This paper deals with three studied landfills, receiving MSW and industrial municipal-like solid wastes. They have been designed, constructed and operated by the same company (in Northern Italy) since 1972. All landfills were realised in degraded areas (quarries), previously used for gravel-sand extraction. Specific construction criteria employed for the different landfills were revised and modified progressively accordingly with current regulation standards and on the basis of previous experience. The analysis of operating data confirm that some factors have influenced leachate production; in particular, among construction criteria: the characteristics of biogas extraction wells (during the opening phase); the type of capping system (during the after-care phase); and, among operation criteria: waste compaction (during the opening phase); the duration of the landfill opening phase (before capping realisation). [Italian] L'obiettivo di questa ricerca (tuttora in corso) e' quello di raccogliere ed analizzare i dati di monitoraggio di alcune discariche per rifiuti solidi urbani, con l'intento di evidenziare eventuali correlazioni fra i criteri costruttivi/gestionali e le caratteristiche delle emissioni. Questo lavoro prende in considerazione 3 discariche in cui sono stati smaltiti rifiuti solidi urbani ed assimilabili. Gli impianti sono stati progettati, costruiti e gestiti, a partire dal 1972, da un'unica azienda che opera nel Nord Italia. Tutte le discariche sono state realizzate in cave dismesse utilizzate per l'estrazione di sabbia e ghiaia. I criteri costruttivi impiegati per le varie discariche sono stati via via modificati in accordo con le specifiche normative e in seguito all'esperienza progressivamente acquisita. L'analisi dei dati gestionali conferma che alcuni fattori hanno influenzato la produzione di percolato; in particolare, per quanto riguarda i criteri costruttivi: le caratteristiche dei pozzi di estrazione del biogas (durante la fase di discarica aperta); le caratteristiche del sistema di copertura (nella fase di post-chiusura); per quanto riguarda i criteri gestionali: la compattazione dei rifiuti (in fase di discarica aperta); la durata del periodo precedente la realizzazione della copertura finale.

Collivignarelli, C.; Bertanza, G.; Cavallari, S. [Brescia Univ., Brescia (Italy). Dipt. di Ingegneria Civile

2001-06-01

125

The relationship between second-year medical students' OSCE scores and USMLE Step 1 scores.  

Science.gov (United States)

The relationship between objective structured clinical examinations (OSCEs) and standardized tests is not well known. We linked second-year medical students' physical diagnosis OSCE scores from 1998, 1999 and 2000 (n = 355) with demographic information, Medical College Admission Test (MCAT) scores, and United States Medical Licensing Examination (USMLE) Step 1 scores. The correlation coefficient for the total OSCE score with USMLE Step 1 score was 0.41 (p < 0.001). Two of 7 skills areas-diagnosis and identification of abnormality-were significant multivariate correlates of USMLE Step 1 score. OSCE station scores accounted for approximately 22% of the variability in USMLE Step 1 scores. A second-year OSCE in physical diagnosis is correlated with scores on the USMLE Step 1 exam, with skills that foreshadow the clinical clerkships most predictive of USMLE scores. This correlation suggests predictive validity of this OSCE and supports the use of OSCEs early in medical school. PMID:12450476

Simon, Steven R; Volkan, Kevin; Hamann, Claus; Duffey, Carol; Fletcher, Suzanne W

2002-09-01

126

Histopathological Study of Chronic Hepatitis B: A Comparative Study of Ishak and METAVIR Scoring Systems  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Ishak and METAVIR scoring systems are among the most commonly used histopathological systems to evaluate chronic hepatitis.Objective: To assess the level of agreement between these two scoring systems in patients with chronic hepatitis B.Methods: Liver biopsy samples taken from 92 patients with chronic hepatitis B were considered as the training set; 57 more biopsy specimens were used as the validation set. In the training set, grade of necroinflammationand stage of fibrosis for each liver biopsy specimen were determined by two expert liver pathologists using both Ishak and METAVIR systems. Inter-observer variability between the two pathologistswas evaluated. Biopsy specimens of the validation set were seen and scored by a third expert pathologist.In the training set, criteria were developed to categorize Ishak grading and staging systems separately to best fit with the METAVIR scoring system. The criteria found in the training set, was then tested in the validation set. The level of agreement between the two scoring systems was assessed by weighted kappa statistics.Results: For the training set, agreement between the two pathologists was excellent. Using our proposed criteria in the training set, there was excellent level of agreement in grading (? = 0.89 and staging (? = 0.99 between Ishak and METAVIR systems. In the validation set, the criteria led to substantial correlation(? = 0.61 in grading, and excellent correlation (? = 0.94 in staging between the two systems.Conclusion: Using our proposed criteria, excellent or at least substantial concordance between Ishak and METAVIR scoring systems can be achieved for the degree of both necro-inflammatory changes and fibrosis.

M. Sotoudeh

2010-10-01

127

Dependence between criteria and multiple criteria decision aid  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In this paper, we present a model allowing to determine the weights related to interacting (correlated) criteria. This is done on the basis of the knowledge of a partial ranking over a reference set of alternatives (prototypes), a partial ranking over the set of criteria, and a partial ranking over the set of interactions between pairs of criteria.

Marichal, Jean-luc; Roubens, Marc

1998-01-01

128

The examination of the relationship between YGS scores and music field scores in music teaching programme with special talent examination  

Directory of Open Access Journals (Sweden)

Full Text Available Every year, with special aptitude exams students are taken to undergraduate programs as a music teacher in Turkey .Although applications for these exam show differences according to the difficulty level of the questions and evaluations criterias, all the areas that would be measured show similarities to each other. The areas showing the similarity are classified as Musical hearing-reading-writing fields (M?OY , musical playing area and musical singing area. Special Ability Test score (ÖYSP Transition to Higher Education Exam scores, as well as forming the points (YGS-P and the weighted scores of Secondary Education (AOBP takes place mainly among the scores of the candidates. It is used according to the circumstances of different coefficients Placement Scores (YP in the calculation. The types of score that form YGS-P and ÖYS, which mainly affect the placemet of the students to the university, the relationship between the musical areas in ÖYSP and all correlations of the areas to each other have been seen as a basical problem of this study.761 candidates who auditioned for Music Education Program in the years 2010-2011 and 2011-2012 academic Inonu University Faculty of Education constitutes the study group . As a result of the analysis made, between the M?OY scores and YGS-P there is a meaningful relationship in positive direction and low level (r =. 08, p <. 05 In adddition, There are positive correlation and low level (r=.32, p<.01; between the musical play and M?OY area points, playing field between the musical scores of M?OY there are positive direction, the low level (r = .21, p <.05 relationship, and it has been found that there is meaningful relationship between musical play area and the Musical direction at a high level. (r=.79, p<.01

Turan Sa?er

2013-03-01

129

Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy - a single centre, open-label study  

LENUS (Irish Health Repository)

Abstract Introduction With the development of increasing numbers of potential therapeutic agents in inflammatory disease comes the need for effective biomarkers to help screen for drug efficacy and optimal dosing regimens early in the clinical trial process. This need has been recognized by the Outcome Measures in Rheumatology Clinical Trials (OMERACT) group, which has established guidelines for biomarker validation. To seek a candidate synovial biomarker of treatment response in psoriatic arthritis (PsA), we determined whether changes in immunohistochemical markers of synovial inflammation correlate with changes in disease activity scores assessing 28 joints (?DAS28) or magnetic resonance imaging synovitis scores (?MRI) in patients with PsA treated with a biologic agent. Methods Twenty-five consecutive patients with PsA underwent arthroscopic synovial biopsies and MRI scans of an inflamed knee joint at baseline and 12 weeks after starting treatment with either anakinra (first 10 patients) or etanercept (subsequent 15 patients) in two sequential studies of identical design. DAS28 scores were measured at both time points. Immunohistochemical staining for CD3, CD68 and Factor VIII (FVIII) was performed on synovial samples and scored by digital image analysis (DIA). MRI scans performed at baseline and at 12 weeks were scored for synovitis semi-quantitatively. The ?DAS28 of the European League Against Rheumatism good response definition (>1.2) was chosen to divide patients into responder and non-responder groups. Differences between groups (Mann Whitney U test) and correlations between ?DAS28 with change in immunohistochemical and MRI synovitis scores (Spearman\\'s rho test) were calculated. Results Paired synovial samples and MRI scans were available for 21 patients (8 anakinra, 13 etanercept) and 23 patients (8 anakinra, 15 etanercept) respectively. Change in CD3 (?CD3) and CD68 expression in the synovial sublining layer (?CD68sl) was significantly greater in the disease responders compared to non-responders following treatment (P = 0.005 and 0.013 respectively). ?CD3, but not ?CD68 or ?FVIII, correlated with both ?DAS28 (r = 0.49, P = 0.025) and ?MRI (r = 0.58, P = 0.009). Conclusions The correlation of ?CD3 with ?DAS28 and ?MRI following biologic treatment in this cohort contributes to the validation of ?CD3 as a synovial biomarker of disease response in PsA, and supports the further evaluation of ?CD3 for predictive properties of future clinical outcomes.

Pontifex, Eliza K

2011-01-27

130

A Simple Clinical Score “TOPRS” to Predict Outcome in Pediatric Emergency Department in a Teaching Hospital in India  

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Full Text Available Objective: To develop a simple clinical scoring system for severity of illness to help prioritize care and predict outcome in emergency department.Methods: Prospective hospital based observational study. Out of a total of 874 children who attended emergency department in one year, 777 were included in the study. Data was collected at the time of admission in emergency department. The baseline information like age, gender, etc and variables of ‘toprs’ score viz temperature, oxygen saturation, pulse rate, respiratory rate, sensorium and seizures were recorded. Variables were categorized as normal (score zero or abnormal (score 1 based on systemic inflammatory response syndrome (SIRS criteria and criteria mentioned in advanced pediatric life support (APLS and the total scores were computed for each child. The outcome (death/discharge was correlated with the study variables and total score. The predictive ability of score was calculated using receiver operating characteristic (ROC curve analysis.Findings: Of the six variables, temperature, oxygen saturation and respiratory rate were found to be significantly associated with mortality. Mortality increased with the increase in the number of abnormal variables. Based on the regression coefficients, maximum possible score was 6.68. The predictive ability of score was 81.7 calculated using ROC curve. Maximum discrimination was observed at a score of 2.5.Conclusion: For triage in emergency, any patient with 2 or more abnormal variables should be closely monitored and evaluated. These patients require admission as they have a potential risk of death.

Ravinder Kumar Soni

2012-03-01

131

The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system      and the EORTC quality of life questionnaires  

DEFF Research Database (Denmark)

BACKGROUND AND PURPOSE: Morbidity is an important issue in cancer       research. The observer-based toxicity scoring system used by DAHANCA (the       Danish head and neck cancer study group) has proved itself sensitive to       differences in toxicity in a large randomised study, but like other       toxicity scoring systems it has not been formally validated. Conversely,       the EORTC quality of life questionnaire (QLQ) has been validated as a tool       for collecting information about the consequences of disease and treatment       on the well being of cancer patients. The purpose of this study was to       examine the relationship between the two methods of side effect recording.       PATIENTS AND METHODS: One hundred and sixteen recurrence free patients       with laryngeal (n=44), pharyngeal (n=34) and oral cavity (n=38) cancer       attending follow-up after radiotherapy (n=83) or surgery (n=33) completed       EORTC C30, the core questionnaire concerning general symptoms and function       and EORTC H&N35 the head and neck specific questionnaire. The attending       physicians in the follow-up clinic evaluated and recorded DAHANCA toxicity       scores on the same patients. RESULTS: The DAHANCA toxicity scoring system       and the EORTC QLQ correlated with several clinical endpoints. The       conceptually similar endpoints of the two methods correlated       significantly. The objective endpoints of the DAHANCA scoring system were       only correlated with quality of life endpoints to a very low degree. The       DAHANCA toxicity scores had a low sensitivity (0.48-0.74) in detecting       equivalent subjective complaints from the questionnaires and the       observer-based scoring system severely underestimated patient complaints.       A specific patient group where the DAHANCA score had a higher tendency to       fail could not be detected. CONCLUSION: The DAHANCA toxicity score is an       effective instrument in assessing objective treatment induced toxicity in       head and neck cancer patients but insensitive and non-specific with regard       to patient assessed subjective endpoints. This weakness seems inherent in       an observer-based scoring system, and will probably also apply to newer       ones like CTCAE 3.0

Jensen, Kenneth; Jensen, Anders Bonde

2006-01-01

132

Discriminating Malaria from Dengue Fever in Endemic Areas: Clinical and Biological Criteria, Prognostic Score and Utility of the C-Reactive Protein: A Retrospective Matched-Pair Study in French Guiana  

Science.gov (United States)

Background Dengue and malaria are two major public health concerns in tropical settings. Although the pathogeneses of these two arthropod-borne diseases differ, their clinical and biological presentations are unspecific. During dengue epidemics, several hundred patients with fever and diffuse pain are weekly admitted at the emergency room. It is difficult to discriminate them from patients presenting malaria attacks. Furthermore, it may be impossible to provide a parasitological microscopic examination for all patients. This study aimed to establish a diagnostic algorithm for communities where dengue fever and malaria occur at some frequency in adults. Methodology/Principal Findings A sub-study using the control groups of a case-control study in French Guiana – originally designed to compare dengue and malaria co-infected cases to single infected cases – was performed between 2004 and 2010. In brief, 208 patients with malaria matched to 208 patients with dengue fever were compared in the present study. A predictive score of malaria versus dengue was established using .632 bootstrap procedures. Multivariate analysis showed that male gender, age, tachycardia, anemia, thrombocytopenia, and CRP>5 mg/l were independently associated with malaria. The predictive score using those variables had an AUC of 0.86 (95%CI: 0.82–0.89), and the CRP was the preponderant predictive factor. The sensitivity and specificity of CRP>5 mg/L to discriminate malaria from dengue were of 0.995 (95%CI: 0.991–1) and 0.35 (95%CI 0.32–0.39), respectively. Conclusions/Significance The clinical and biological score performed relatively well for discriminating cases of dengue versus malaria. Moreover, using only the CRP level turned to be a useful biomarker to discriminate feverish patients at low risk of malaria in an area where both infections exist. It would avoid more than 33% of unnecessary parasitological examinations with a very low risk of missing a malaria attack.

Epelboin, Loic; Boulle, Charlotte; Ouar-Epelboin, Sihem; Hanf, Matthieu; Dussart, Philippe; Djossou, Felix; Nacher, Mathieu; Carme, Bernard

2013-01-01

133

Prognostic value of perfusion defect volume at dual energy CTA in patients with pulmonary embolism: Correlation with CTA obstruction scores, CT parameters of right ventricular dysfunction and adverse clinical outcome  

International Nuclear Information System (INIS)

Purpose: To investigate the prognostic value of perfusion defect volume (PDvol) at dual-energy-CT-angiography (DE-CTA) in patients with acute pulmonary embolism (PE) by correlating PDvol with CTA-obstruction-scores (OS), CT parameters of right-ventricular-dysfunction (RVD), and adverse-clinical-outcome. Materials and methods: DE-CTA of 60 patients (mean age: 65 ± 14.4 years) with PE were analyzed. Iodine maps were generated, and normalized PDvol – defined as volume of perfusion defects/total lung volume – was quantified. Furthermore, established prognostic parameters (Qanadli and Mastora-OS, and CT parameters of RVD) were obtained. CT parameters of RVD – namely the right ventricle/left ventricle (RV/LV) diameter ratio measured on transverse sections (RV/LVtrans), four-chamber views (RV/LV4ch), and RV/LV volume ratios (RV/LVvol) – were assessed. PDvol was correlated with OS, CT parameters of RVD and adverse clinical outcome (defined as the need for intensive care treatment or death). Results: 10 of 60 patients with PE experienced adverse clinical outcome. Patients with adverse clinical outcome showed significantly higher PDvol (35 ± 11% vs. 23 ± 10%, p = 0.002), RV/LV ratios (RV/LV4ch 1.46 ± 0.32 vs. 1.18 ± 0.26, p = 0.005; RV/LVvol 2.25 ± 1.33 vs. 1.19 ± 0.56, p = 0.002) and higher Mastora global scores (52 vs. 13, p = 0.02) compared to those without adverse clinical outcome. A weak correlation was observed between PDvol and the Mastora global score (r = 0.5; p = 0.0003), as well as between PDvol and RV/LV4Ch (r = 0.432, p = 0.0006). No correlation was found between PDvol and the Qanadli score or the remainder of the RVD-CT parameters. Conclusion: The extent of perfusion defects as assessed by DE-CTA correlates with adverse clinical outcome in patients with PE. Therefore, volumetric quantification of perfusion defects at DE-CTA allows the identification of low-risk patients who do not require intensified monitoring and treatment.

2012-11-01

134

Prognostic value of perfusion defect volume at dual energy CTA in patients with pulmonary embolism: Correlation with CTA obstruction scores, CT parameters of right ventricular dysfunction and adverse clinical outcome  

Energy Technology Data Exchange (ETDEWEB)

Purpose: To investigate the prognostic value of perfusion defect volume (PDvol) at dual-energy-CT-angiography (DE-CTA) in patients with acute pulmonary embolism (PE) by correlating PDvol with CTA-obstruction-scores (OS), CT parameters of right-ventricular-dysfunction (RVD), and adverse-clinical-outcome. Materials and methods: DE-CTA of 60 patients (mean age: 65 {+-} 14.4 years) with PE were analyzed. Iodine maps were generated, and normalized PDvol - defined as volume of perfusion defects/total lung volume - was quantified. Furthermore, established prognostic parameters (Qanadli and Mastora-OS, and CT parameters of RVD) were obtained. CT parameters of RVD - namely the right ventricle/left ventricle (RV/LV) diameter ratio measured on transverse sections (RV/LVtrans), four-chamber views (RV/LV4ch), and RV/LV volume ratios (RV/LVvol) - were assessed. PDvol was correlated with OS, CT parameters of RVD and adverse clinical outcome (defined as the need for intensive care treatment or death). Results: 10 of 60 patients with PE experienced adverse clinical outcome. Patients with adverse clinical outcome showed significantly higher PDvol (35 {+-} 11% vs. 23 {+-} 10%, p = 0.002), RV/LV ratios (RV/LV4ch 1.46 {+-} 0.32 vs. 1.18 {+-} 0.26, p = 0.005; RV/LVvol 2.25 {+-} 1.33 vs. 1.19 {+-} 0.56, p = 0.002) and higher Mastora global scores (52 vs. 13, p = 0.02) compared to those without adverse clinical outcome. A weak correlation was observed between PDvol and the Mastora global score (r = 0.5; p = 0.0003), as well as between PDvol and RV/LV4Ch (r = 0.432, p = 0.0006). No correlation was found between PDvol and the Qanadli score or the remainder of the RVD-CT parameters. Conclusion: The extent of perfusion defects as assessed by DE-CTA correlates with adverse clinical outcome in patients with PE. Therefore, volumetric quantification of perfusion defects at DE-CTA allows the identification of low-risk patients who do not require intensified monitoring and treatment.

Apfaltrer, Paul, E-mail: paul.apfaltrer@medma.uni-heidelberg.de [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Bachmann, Valentin, E-mail: valentin.bachmann@googl.com [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Meyer, Mathias, E-mail: mr.meyer.mathias@gmail.com [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Henzler, Thomas, E-mail: Thomas.Henzler@umm.de [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Barraza, John M., E-mail: barraza@musc.edu [Department of Radiology and Radiological Science, Medical University of South Carolina, PO Box 250322, 169 Ashley Avenue, Charleston, SC 29425 (United States); Gruettner, Joachim, E-mail: joachim.gruettner@umm.de [1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Walter, Thomas, E-mail: Thomas.Walter2@umm.de [1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Schoepf, U. Joseph, E-mail: schoepf@musc.edu [Department of Radiology and Radiological Science, Medical University of South Carolina, PO Box 250322, 169 Ashley Avenue, Charleston, SC 29425 (United States); and others

2012-11-15

135

Diagnostic value of a breast MRI score for the prediction of malignancy of breast lesions detected solely with MRI  

International Nuclear Information System (INIS)

Purpose: to determine whether lesion scoring allows valid BI-RADS registered classification and prediction of malignancy of breast lesions detectable solely with MRI. Materials and methods: retrospective analysis of 86 patients who underwent MRI-guided localization and excisional biopsy of 100 breast lesions detectable only with MRI. Breast MRI was performed at 1.5 Tesla by means of a T1w dynamic GE sequence. The positive predictive value (PPV) for malignancy was calculated for each score criterion separately, for the total score, and for corresponding BI-RADS registered classes. The PPV was correlated with histology. Results: 31% (31/100) of breast lesions detectable only with MRI were malignant. Of the single score criteria only the lesion morphology criterion was significantly correlated with malignancy. The malignancy rate according to the breast MRI score was 0% for score 3, 18.2% for score 4, 32.1% for score 5 and each 50% for lesions of score 6 and 7. After translation into BI-RADS registered the malignancy rates were 0% for BI-RADS registered 3, 24.6% for BI-RADS registered 4 and 48.5% for BI-RADS registered 5 lesions. The thus defined BI-RADS registered classes were significantly correlated with malignancy. (orig.)

2009-06-01

136

78 FR 15956 - Guidance for Industry on Tablet Scoring: Nomenclature, Labeling, and Data for Evaluation...  

Science.gov (United States)

...both NDA and ANDA scored tablet products. To accomplish...criteria by which scored tablets can be evaluated and labeled...harmonized approach to chemistry, manufacturing, and controls reviews of scored tablets; (2) ensuring...

2013-03-13

137

Evaluation Criteria  

Science.gov (United States)

Evaluation Criteria Stage I: Scientific Merit (non-NCI reviewers): Strength of scientific evidence and hypothesis Certification (biochemical or physiological validation) Potential clinical impact Feasibility Novelty Stage II: Operational Feasibility

138

Magnetic resonance imaging versus Acute Physiology And Chronic Healthy Evaluation II score in predicting the severity of acute pancreatitis  

International Nuclear Information System (INIS)

Objective: To study the correlation between established magnetic resonance (MR) imaging criteria of disease severity in acute pancreatitis and the Acute Physiology And Chronic Healthy Evaluation II (APACHE II) score, and to assess the utility of each prognostic indicators in acute pancreatitis. Materials and methods: In this study there were 94 patients with acute pancreatitis (AP), all had abdominal MR imaging. MR findings were categorized into edematous and necrotizing AP and graded according to the MR severity index (MRSI). The APACHE II score was calculated within 24 h of admission, and local complications, death, duration of hospitalization and ICU were recorded. Statistical analysis was performed to determine their correlation. Results: In patients with pancreatitis, no significant correlation can be found between the APACHE II score and the MRSI score (P = 0.196). The MRSI score correlated well with morbidity (P = 0.006) but not with mortality (P = 0.137). The APACHE II score correlated well with mortality (P = 0.002) but not with the morbidity (P = 0.112). The MRSI score was superior to the APACHE II score as a predictor of the length of hospitalization (r = 0.52 vs. r = 0.35). A high MRSI and APACHE II score correlated with the need for being in the intensive care unit (ICU) (P = 0.000 and P = 0.000, respectively). Conclusion: In patients with pancreatitis, MRSI is superior to APACHE II in assessing local complications from pancreatitis but has a limited role in determining systemic complications in which the APACHE II score excels.

2011-12-01

139

Correlação de três variáveis na descrição da permeabilidade nasal (HD, MCA, escala NOSE de pacientes saudáveis Correlation of three variables describing nasal patency (HD, MCA, NOSE score in healthy subjects  

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Full Text Available Rinoresistometria e rinometria acústica são dois métodos utilizados na avaliação da função respiratória nasal. Ambos utilizam variáveis diferentes para descrever a permeabilidade nasal: o diâmetro hidráulico, HD, na rinoresistometria; e as áreas mínimas da seção transversal, MCA1 (istmo nasal e MCA2 (cabeça do corneto inferior e corpo cavernoso do septo nasal, na rinometria acústica. OBJETIVO: Analisar a relação entre HD e MCA em pacientes sem afecções nasais e identificar se tais variáveis objetivas apresentam correlação com a escala NOSE, uma ferramenta validada para avaliar a percepção subjetiva de permeabilidade nasal. MÉTODO: Coleta estruturada dos dados de 24 indivíduos saudáveis sem afecções nasais. RESULTADOS: Correlações estatisticamente significativas de fracas a moderadas foram identificadas entre HD e MCA2 antes do descongestionamento. Foi identificada correlação moderada entre HD, MCA2 e escala NOSE no lado mais estreito. CONCLUSÃO: Na avaliação de permeabilidade nasal, parece ser recomendável determinar HD, MCA1 e MCA2, bem como uma variável subjetiva como a escala NOSE, que não aparentam ser variáveis completamente redundantes. Estudos futuros devem avaliar a correlação destas variáveis em pacientes com afecções nasais.Rhinoresistometry and acoustic rhinometry are two established apparative methods to objectify the respiratory function of the nose. Both methods use different variables to describe nasal patency: "hydraulic diameter", HD, in rhinoresistometry, and "minimal cross-sectional area", MCA1 (nasal isthmus and MCA2 (head of the inferior turbinate and cavernous body of the nasal septum, in acoustic rhinometry. OBJECTIVE: This study analyzes the mutual correlation of HD and MCA as a pilot study in patients without nasal pathologies. Additionally, we investigated if these objective variables correlate with the NOSE score, a validated tool to measure subjective perception of nasal patency. METHOD: Planned data collection in a collective of 24 healthy subjects without nasal pathologies. RESULTS: Statistically significant, weak to moderate correlations were found between HD and MCA2 before decongestion. A moderate correlation was found between both HD and MCA2 and the NOSE score on the narrower side. CONCLUSION: In the assessment of nasal patency, it seems advisable to determine HD, MCA1 and MCA2, but also a subjective variable such as the NOSE score, which all seem to be not fully redundant variables. In further studies, the correlation of the variables should be assessed in patients with nasal pathologies.

Thomas Braun

2013-06-01

140

Test Scoring [book review].  

Science.gov (United States)

This book discusses how to obtain test scores and, in particular, how to obtain test scores from tests that consist of a combination of multiple choice and open-ended questions. The strength of the book is that scoring solutions are presented for a diversity of real world scoring problems. (SLD)

Meijer, Rob R.

2003-01-01

 
 
 
 
141

Electrocardiographic diagnosis of left ventricular hypertrophy in aortic valve disease: evaluation of ECG criteria by cardiovascular magnetic resonance  

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Full Text Available Abstract Background Left ventricular hypertrophy (LVH is a hallmark of chronic pressure or volume overload of the left ventricle and is associated with risk of cardiovascular morbidity and mortality. The purpose was to evaluate different electrocardiographic criteria for LVH as determined by cardiovascular magnetic resonance (CMR. Additionally, the effects of concentric and eccentric LVH on depolarization and repolarization were assessed. Methods 120 patients with aortic valve disease and 30 healthy volunteers were analysed. As ECG criteria for LVH, we assessed the Sokolow-Lyon voltage/product, Gubner-Ungerleider voltage, Cornell voltage/product, Perugia-score and Romhilt-Estes score. Results All ECG criteria demonstrated a significant correlation with LV mass and chamber size. The highest predictive values were achieved by the Romhilt-Estes score 4 points with a sensitivity of 86% and specificity of 81%. There was no difference in all ECG criteria between concentric and eccentric LVH. However, the intrinsicoid deflection (V6 37 ± 1.0 ms vs. 43 ± 1.6 ms, p Conclusion By calibration with CMR, a wide range of predictive values was found for the various ECG criteria for LVH with the most favourable results for the Romhilt-Estes score. As electrocardiographic correlate for concentric LVH as compared with eccentric LVH, a shorter intrinsicoid deflection and a significant ST-segment and T-wave depression in the anterolateral leads was noted.

Feuerbach Stefan

2009-06-01

142

2011 Y?l? Yönetici Atama ve Yer De?i?tirme Yönetme?i’nin ?çeri?ine ve Puanlama Ölçütlerine ?li?kin Yönetici Görü?lerinin ?ncelenmesi Investigation of Manager Opinions on the Content and Scoring Criteria of the 2011 Manager Appointment and Rotation Regulations  

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Full Text Available Purpose: This study aims at determining the opinions of managersrelating to the Manager Appointment and Rotation Regulations dated2011, the scoring criteria included in the regulations and the troublesexperienced throughout the implementation process of the regulations.Method: In this research, a qualitative approach was adopted sothat the issue can be examined thoroughly. In this research, thephenomenological pattern was employed. In the research, participantswere determined by way of sampling for maximum diversity-one of theintentional sampling methods. The study group of the research consistsof 8 managers holding Office in the city X (pseudonym. Terms of Officeof the participants varies between 25 and 8 years. Semi-structuredinterview form was used as data collection tools in the research. All theinterviews were recorded on a tape recorder throughout the research. A240-minute interview was had within the scope of the research; the taperecording was computerized through the Microsoft Word processingprogram as raw data without being subjected to any screening.Line by line analysis described by Patton, (2002 was employed todescribe opinions expressed clearly and directly or implied in anindirect manner by the participants on the aim of the study withoutmanipulating them. Inductive descriptive analysis, content analysis andthe constant comparison technique was used in the interpretation ofthe interview data. The descriptive analysis project is made up of fourmain stages, namely, building up the thematic framework, processingdata according to the thematic framework, identifying the findings andinterpreting the findings.During content analysis, on the other hand, the data was dividedinto parts first and then these parts were investigated and compared.Later, meaningful concepts were built from these parts and the codesevoking the same concepts were grouped under a joint category. In thefinal stage, content integrity was derived from the themes stemmingfrom the data and interpreted.While developing an interview form, a conceptual frameworkrelating to the subject matter was formed by investigating the relatedbody of literature for the purposes of increasing credibility/ internalvalidity of the research. Each stage of the research process wasprovided to the reader in a detailed manner so that thetransferability/external validity of the research could be insured. Theresearcher has watched over to write his research report in detail andtried to present detailed descriptions in the findings part.All the data obtained throughout the research process wasevaluated and separately coded by the researcher and an instructor,who has a command of qualitative research methods and a consensuswas reached on the codings in general terms. Results: As a result of analysis of the data, three main subjects, namely, 1. Evaluations relating to the appointment and change of Office of managers, 2. Evaluations relating to the content of the Manager Appointment and Change of Office Regulations and to the scoring principles, 3. Evaluations relating to compulsory rotation appeared.As a result of the story, it was concluded that the belief that the awards (certificates of appreciation and high achievement granted by the Ministry of National Education central organization and provincial organizations and by the related civilian authority are not offered based on merits, justice and qualification and in line with objective criteria dominated the participants and based on this idea, they had the idea that scoring of these awards in the manager appointment process may lead to unfair competition and injustice.It was found out in the study that the participants objected not to the scoring of the awards in the appointment of manager; just to the contrary, they argued against the scoring of these awards in the manager appointment process based on the idea that the awards granted were not given according to objective criteria.It was observed that the participants believing that there is a relationship between the term of Office and experience an

Selçuk Be?ir DEM?R

2013-07-01

143

Using Minimum Acceptable GRE Scores for Graduate Admissions Suppresses Diversity  

Science.gov (United States)

I will present data showing that significant performance disparities on the GRE general test exist based on the test taker's race and gender [1]. Because of the belief that high GRE scores qualify one for graduate studies, the diversity issues faced by STEM fields may originate, at least in part, in misuse of the GRE scores by graduate admissions committees. I will quantitatively demonstrate this by showing that the combination of a hard cut-off and the different score distributions leads to the systematic underrepresentation of certain groups. I will present data from USF’s PhD program that shows a lack of correlation between GRE scores and research ability; similar null results are emerging from numerous other programs. I will then discuss how assessing non-cognitive competencies in the selection process may lead to a more enlightened search for the next generation of scientists. [1] C. W. Miller, "Admissions Criteria and Diversity in Graduate School", APS News Vol 22, Issue 2, The Back Page (2013) http://www.aps.org/publications/apsnews/201302/backpage.cfm

Miller, Casey

2014-01-01

144

Assessment of lung disease in children with cystic fibrosis using hyperpolarized 3-Helium MRI: comparison with Shwachman score, Chrispin-Norman score and spirometry  

International Nuclear Information System (INIS)

This study assesses the feasibility of hyperpolarized 3-Helium MRI in children with cystic fibrosis (CF) and correlates the findings with standard clinical parameters based on chest radiograph (CXR) and pulmonary function tests (PFT). An uncontrolled, observational study in eighteen children with cystic fibrosis aged 5 - 17 years (median 12.1 years), with different severity of disease was carried out. All subjects underwent routine clinical assessment including PFT and standard auxology; CXR was obtained and Shwachman and Chrispin-Norman scores calculated. Hyperpolarized 3-He magnetic resonance imaging (MRI) was carried out using a spin-exchange polarizer and a whole body 1.5 T scanner. Ventilation distribution images were obtained during a 21-second breath-hold and scored according to previously defined criteria. Spearman's non-parametric correlations test was performed to assess for statistical significance at the p<0.05 level. The children tolerated the procedure well. No desaturation events were observed during 3-He MRI. A significant, albeit moderate, correlation was found between MRI score and FEV1% predicted (r=-0.41; p=0.047) and FVC% predicted (r=-0.42; p=0.04), while there were trends of correlations between Shwachman score and MRI score (r=-0.38; p=0.06) and Shwachman score and FEV1% predicted (r=0.39; p=0.055). The feasibility of hyperpolarized 3-He MRI in children with CF was demonstrated. MRI appears to be able to demonstrate functional lung changes, although correlations with routine clinical tests are only moderate to poor. This non-ionising radiation technique could be useful for monitoring lung disease and assessing therapy in this patient population. (orig.)

2007-04-01

145

Assessment of lung disease in children with cystic fibrosis using hyperpolarized 3-Helium MRI: comparison with Shwachman score, Chrispin-Norman score and spirometry  

Energy Technology Data Exchange (ETDEWEB)

This study assesses the feasibility of hyperpolarized 3-Helium MRI in children with cystic fibrosis (CF) and correlates the findings with standard clinical parameters based on chest radiograph (CXR) and pulmonary function tests (PFT). An uncontrolled, observational study in eighteen children with cystic fibrosis aged 5 - 17 years (median 12.1 years), with different severity of disease was carried out. All subjects underwent routine clinical assessment including PFT and standard auxology; CXR was obtained and Shwachman and Chrispin-Norman scores calculated. Hyperpolarized 3-He magnetic resonance imaging (MRI) was carried out using a spin-exchange polarizer and a whole body 1.5 T scanner. Ventilation distribution images were obtained during a 21-second breath-hold and scored according to previously defined criteria. Spearman's non-parametric correlations test was performed to assess for statistical significance at the p<0.05 level. The children tolerated the procedure well. No desaturation events were observed during 3-He MRI. A significant, albeit moderate, correlation was found between MRI score and FEV1% predicted (r=-0.41; p=0.047) and FVC% predicted (r=-0.42; p=0.04), while there were trends of correlations between Shwachman score and MRI score (r=-0.38; p=0.06) and Shwachman score and FEV1% predicted (r=0.39; p=0.055). The feasibility of hyperpolarized 3-He MRI in children with CF was demonstrated. MRI appears to be able to demonstrate functional lung changes, although correlations with routine clinical tests are only moderate to poor. This non-ionising radiation technique could be useful for monitoring lung disease and assessing therapy in this patient population. (orig.)

Beek, Edwin J.R. van [University of Sheffield, Unit of Academic Radiology, Sheffield (United Kingdom); University of Iowa, Department of Radiology, Carver College of Medicine, Iowa City (United States); University of Iowa, Department of Radiology, Iowa City, IA (United States); Hill, Catherine; Woodhouse, Neil; Fichele, Stanislao; Fleming, Sally; Wild, Jim M. [University of Sheffield, Unit of Academic Radiology, Sheffield (United Kingdom); Howe, Bridget; Bott, Sandra; Taylor, Christopher J. [University of Sheffield, Academic Unit of Child Health, Sheffield (United Kingdom)

2007-04-15

146

Image quality criteria in cardiology  

International Nuclear Information System (INIS)

Image quality evaluation plays a key role in the process of optimisation in radiological procedures. Image quality criteria for cardiac cine-angiography were recently agreed as part of a European Research Project, and a scoring system based on these criteria has been developed to allow an 'objective' measurement of the quality of cardiac angiograms. Two studies aimed at the evaluation of the methodology have been completed, demonstrating that the method can be applied to cardiac images and translated into a scoring system that yields reproducible data. Based on the results of these studies, quality criteria have been further reviewed by DIMOND III panel and the updated version is presented in this paper. (authors)

2004-03-25

147

Genetic effect on apgar score  

Directory of Open Access Journals (Sweden)

Full Text Available Intraclass correlation coefficients for one- and five-min Apgar scores of 604 twin pairs born at a southeastern Brazilian hospital were calculated, after adjusting these scores for gestational age and sex. The data support a genetic hypothesis only for 1-min Apgar score, probably because it is less affected by the environment than 4 min later, after the newborns have been under the care of a neonatology team. First-born twins exhibited, on average, better clinical conditions than second-born twins. The former showed a significantly lower proportion of Apgar scores under seven than second-born twins, both at 1 min (17.5% vs. 29.8% and at 5 min (7.2% vs. 11.9%. The proportion of children born with "good" Apgar scores was significantly smaller among twins than among 1,522 singletons born at the same hospital. Among the latter, 1- and 5-min Apgar scores under seven were exhibited by 9.2% and 3.4% newborns, respectively.

Franchi-Pinto Carla

1999-01-01

148

Analysis of Project Success Criteria in the Nigerian Construction Industry  

Directory of Open Access Journals (Sweden)

Full Text Available This paper examined the relative importance of the project success criteria in the Nigerian construction industry. It also determined the correlation among the project success criteria. Based on the literatures reviewed, the study proposed a framework for measuring project success in the construction industry. The respondents for the study were the government, private clients, consultants and contractors. Three hundred copies of questionnaires were distributed to capture data on the subject, but only 86 were returned and used for the study. The paper captured respondents that are resident in Lagos state, Nigeria and chosen by convenience from selected organizations used for the study. The data were analysed with SPSS 16 through the use of frequencies, mean scores, factor analysis and correlation. Factor analysis was employed because the mean scores showed that all the project success criteria were at least important. Nine principal components were finally merged into 4 through the factor analysis using the Varimax rotation with Keiser normalization. The study found out that all the project success criteria were important but their level of importance differs according to the factor analysis carried out. Therefore, it was concluded that there are four major components of construction project success in Nigeria- user-related factors, professionals’ factors, organisational factors and other minor factors. The minor factors were found to be related to both organizations and projects but were not highly rated by respondents for determining construction project success. The study also concludes that project success criteria goes beyond meeting cost, time and quality target, it includes users’ satisfaction, professionals’ fulfilment and achievement of organizational goals. The recommendation of the study was that for construction projects to be successful, attention must be paid to users’ related factors, professionals’ factors and organizations’ factors.

Oluwaseun Sunday Dosumu

2013-02-01

149

Likelihood ratio-based biometric score fusion.  

Science.gov (United States)

Multibiometric systems fuse information from different sources to compensate for the limitations in performance of individual matchers. We propose a framework for optimal combination of match scores that is based on the likelihood ratio test. The distributions of genuine and impostor match scores are modeled as finite Gaussian mixture model. The proposed fusion approach is general in its ability to handle (i) discrete values in biometric match score distributions, (ii) arbitrary scales and distributions of match scores, (iii) correlation between the scores of multiple matchers and (iv) sample quality of multiple biometric sources. Experiments on three multibiometric databases indicate that the proposed fusion framework achieves consistently high performance compared to commonly used score fusion techniques based on score transformation and classification. PMID:18084063

Nandakumar, Karthik; Chen, Yi; Dass, Sarat C; Jain, Anil K

2008-02-01

150

Dual-energy X-ray absorptiometry diagnostic discordance between Z-scores and T-scores in young adults.  

LENUS (Irish Health Repository)

Diagnostic criteria for postmenopausal osteoporosis using central dual-energy X-ray absorptiometry (DXA) T-scores have been widely accepted. The validity of these criteria for other populations, including premenopausal women and young men, has not been established. The International Society for Clinical Densitometry (ISCD) recommends using DXA Z-scores, not T-scores, for diagnosis in premenopausal women and men aged 20-49 yr, though studies supporting this position have not been published. We examined diagnostic agreement between DXA-generated T-scores and Z-scores in a cohort of men and women aged 20-49 yr, using 1994 World Health Organization and 2005 ISCD DXA criteria. Four thousand two hundred and seventy-five unique subjects were available for analysis. The agreement between DXA T-scores and Z-scores was moderate (Cohen\\'s kappa: 0.53-0.75). The use of Z-scores resulted in significantly fewer (McNemar\\'s p<0.001) subjects diagnosed with "osteopenia," "low bone mass for age," or "osteoporosis." Thirty-nine percent of Hologic (Hologic, Inc., Bedford, MA) subjects and 30% of Lunar (GE Lunar, GE Madison, WI) subjects diagnosed with "osteoporosis" by T-score were reclassified as either "normal" or "osteopenia" when their Z-score was used. Substitution of DXA Z-scores for T-scores results in significant diagnostic disagreement and significantly fewer persons being diagnosed with low bone mineral density.

Carey, John J

2009-01-01

151

Predictors of MCAT scores for black Americans.  

Science.gov (United States)

If minority students likely to score low on the Medical College Admissions Test (MCAT) can be identified in advance, they can be advised to take existing preparatory programs, or programs can be developed to meet their needs. Correlation coefficients for a number of available independent variables with MCAT scores were determined for a population of premedical students at Xavier University of Louisiana. American College Testing (ACT) and Scholastic Aptitude Test (SAT) scores were found to have similar ability to predict MCAT scores, with a correlation coefficient of 0.64 between ACT composite and MCAT total scores. Correlations of sophomore year grade point average (GPA) with MCAT scores were only slightly weaker. Use of subtest scores for the ACT and SAT, grades in science courses, and Nelson-Denny Reading Test scores did not improve prediction to any real extent, either when used alone or in multiple linear regression analysis. In contrast to some previous studies, predictions for black men were as good as those for black women. Use of only ACT composite and sophomore year GPA together gave correlations only slightly weaker than predictions using a full range of variables; data from ACT composite and sophomore year GPA can be used for calculating predictive equations on many available micro-computers. These procedures may not be applicable to minority students at majority institutions. PMID:3612830

Carmichael, J W; Bauer, J; Hunter, J R; Labat, D D; Sevenair, J P

1987-06-01

152

Observed Score Linear Equating with Covariates  

Science.gov (United States)

This paper examined observed score linear equating in two different data collection designs, the equivalent groups design and the nonequivalent groups design, when information from covariates (i.e., background variables correlated with the test scores) was included. The main purpose of the study was to examine the effect (i.e., bias, variance, and…

Branberg, Kenny; Wiberg, Marie

2011-01-01

153

Is dimensional scoring of borderline personality disorder important only for subthreshold levels of severity?  

Science.gov (United States)

Studies comparing dimensional and categorical representations of personality disorders (PDs) have consistently found that PD dimensions are more reliable and valid. While comparisons of dimensional and categorical scoring approaches have consistently favored the dimension model, two reports from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project have raised questions as to when dimensional scoring is important. In the first study, Asnaani, Chelminski, Young, and Zimmerman (2007) found that once the diagnostic threshold for borderline PD was reached the number of criteria met was not significantly associated with indices of psychosocial morbidity. In the second study, Zimmerman, Chelminski, Young, Dalrymple, and Martinez (2012) found that patients with 1 criterion of borderline PD had significantly more psychosocial morbidity than patients with 0 criteria. The findings of these two studies suggest that dimensional ratings of borderline PD may be more strongly associated with indicators of illness severity for patients who do not versus do meet the DSM-IV criteria for borderline PD. In this third report from the MIDAS project, we tested this hypothesis in a study of 3,069 psychiatric outpatients evaluated with semi-structured diagnostic interviews. In the patients without borderline PD the number of borderline features was significantly associated with each of 6 indicators of illness severity, whereas in the patients with borderline PD 3 of the 6 correlations were significant. The mean correlation between the number of borderline PD criteria and the indicators of illness severity was nearly three times higher in the patients without borderline PD than the patients with borderline PD (0.23 versus 0.08), and 4 of the 6 correlation coefficients were significantly higher in the patients without borderline PD. These findings suggest that dimensional scoring of borderline PD is more important for subthreshold levels of pathology and are less critical once a patient meets the diagnostic threshold. The implications of these findings for DSM-5 are discussed. PMID:23514187

Zimmerman, Mark; Chelminski, Iwona; Young, Diane; Dalrymple, Kristy; Martinez, Jennifer

2013-04-01

154

Correlações genéticas de características de tamanho corporal e condição corporal com características de eficiência produtiva de fêmeas da raça Canchim / Genetic correlations among cow body size, condition score and productive traits in Canchim cows  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Os objetivos neste trabalho foram estimar a herdabilidade do número (NBZ10 e NBZT) e quilogramas de bezerros desmamados (QBD10 e QBDT) pela vaca até dez anos de idade e durante a permanência da fêmea no rebanho e de quilogramas de bezerros desmamados pela vaca por ano de permanência no rebanho (QTPR [...] ) e as correlações genéticas dessas características com os pesos ajustados e não-ajustados para condição corporal, índice de tamanho corporal e condições corporais à primeira monta, ao primeiro parto e à idade adulta, idades ao primeiro, segundo e terceiro partos e tempo de permanência no rebanho. Os componentes de variância e de co-variância foram estimados pelo método da máxima verossimilhança restrita livre de derivadas, usando-se análises uni e bicaracterísticas. Os modelos estatísticos incluíram o efeito genético aditivo direto, como aleatório, e o efeito fixo de grupo de contemporâneos. As estimativas de herdabilidade obtidas das análises unicaracterísticas foram 0,10 ± 0,05 (NBZT), 0,10 ± 0,03 (QBDT), 0,12 ± 0,05 (NBZ10), 0,13 ± 0,05 (QBD10) e 0,15 ± 0,05 (QTPR), indicando que baixa resposta à seleção será obtida para essas características. A seleção para redução na idade ao primeiro parto não incrementará a produtividade das vacas. A seleção para aumentar o peso adulto das fêmeas acarretará redução em QTPR, NBZ10 e NBZT. A seleção para os índices de tamanho corporal ou para os pesos ajustados para condição corporal deve apresentar respostas correlacionadas com as características produtivas das fêmeas com tendências semelhantes, mas de maior magnitude que a seleção para peso da fêmea sem ajuste. Abstract in english The objectives of this study were to obtain heritability estimates for number (NBZ10 and NBZT) and kilograms (QBD10 and QBDT) of calves weaned up to ten years of age and during herd life, kilograms of calves weaned per year in herd (QTPR) and their genetic correlations with culling age, ages at firs [...] t, at second and at third calving, adjusted and unadjusted weights for condition score, body size indexes and condition score at first mating, at first calving and at mature age. Variance and covariance components were estimated by REML using univariate and bivariate models including the fixed effect of contemporary group and additive direct genetic and residual as random effects. Heritability estimates obtained from univariate analyses were 0.10 ± 0.05 (NBZT), 0.10 ± 0.03 (QBDT), 0.12 ± 0.05 (NBZ10), 0.13 ± 0.05 (QBD10) and 0.15 ± 0.05 (QTPR) and indicate low response by selection on these traits. Genetic correlation estimate suggest that selection for reducing age at first calving will not improve cow productivity. Selection for increasing mature weight will reduce kilograms of calves weaned per year in herd and the number of calves weaned up to ten years of age and during herd life. Selection on body size indexes and on cow weights adjusted for condition score may result in similar correlated responses in productive traits of cows, which would be higher than those from selection on unadjusted cow weights.

Fernando, Baldi; Mauricio Mello de, Alencar; Alfredo Ribeiro de, Freitas.

155

Prediction of bronchopulmonary dysplasia by chest radiographic scoring system at seven days of age  

International Nuclear Information System (INIS)

Recent trials of preventive dexamethasone therapy in preterm neonates at high risk of developing bronchopulmonary dysplasia (BPD) have required the objective criteria for prediction of BPD in the early neonatal period. The purpose of this study is to determine whether a chest radiographic scoring system at 7 days of age can be used to predict BPD. Chest radiographs taken at 7 days and 28 days of age in 59 preterm neonates(gestational age of less than 33 weeks) were scored prospectively according to the consensus of two radiologists. The 7-day radiographs were scored according to a system derived from Yuksel's method:endotracheal tube insertion, degree of lung inflation, lung opacification, interstitial changes and cardiomegaly were measured. The radiographs taken at 28 days were scored according to a modification of Toce's method. The BPD group was defined as consisting of patients who needed oxygen therapy for more than 28 days and showed abnormality on chest radiographs. Scores were analysed to determine whether there were any statistical differences between the BPD and non-BPD groups, whether there was a significant correlation between scores at 7 days and 28 days, and whether there was any relationship between scores at 7 days of age and the development of BPD. We tried to determine which factors, as indicated by the scores at 7 days, significantly contributed to the development of BPD. The mean scores at 7 days of age in the BPD group (n=18) were 4.3±1.5 (2-7), and those in the non-BPD group (n=41) were 2.2±1.2 (0-4). The differences were statistically significant (p<.0001). Significant correlation was found between scores at 7 days and at 28 days of age(r:0.57, p<.0001). Analysis showed that endotracheal tube insertion, cardiomegaly, and degree of interstitial change, as seen on radiographs at 7 days, were factors which significantly contributed to the development of BPD (p<0.05 each). All neonates with a score of 5 or more developed BPD (7/7), while those with a score of less than 2 did not (0/11). The chest radiographic scoring system used at 7 days of age can be helpful in predicting the development of BPD. We believe that this system can be used to indicate the need for early preventive steroid therapy

1997-03-01

156

score-network.org  

...) Professor Rajkumar Roy Head of Decison Engineering Centre Cranfield University Bedford, UK member (SCORE!) Aguinaldo dos Santos Head of the Sustainable Design Research Center Federal University of Paraná...

157

Genetic parameters for androstenone, skatole, indole, and human nose scores as measures of boar taint and their relationship with finishing traits.  

Science.gov (United States)

The purpose of this study was to evaluate measures of boar (Sus scrofa) taint as potential selection criteria to reduce boar taint so that castration of piglets will become unnecessary. Therefore, genetic parameters of boar taint measures and their genetic correlations with finishing traits were estimated. In particular, the usefulness of a human panel assessing boar taint (human nose score) was compared with chemical assessment of boar taint compounds, androstenone, skatole, and indole. Heritability estimates for androstenone, skatole, and indole were 0.54, 0.41, and 0.33, respectively. The heritability for the human nose score using multiple panelists was 0.12, and ranged from 0.12 to 0.19 for individual panelists. Genetic correlations between scores of panelists were generally high up to unity. The genetic correlations between human nose scores and the boar taint compounds ranged from 0.64 to 0.999. The boar taint compounds and human nose scores had low or favorable genetic correlations with finishing traits. Selection index estimates indicated that the effectiveness of a breeding program based on human nose scores can be comparable to a breeding program based on the boar taint compounds themselves. Human nose scores can thus be used as a cheap and fast alternative for the costly determination of boar taint compounds, needed in breeding pigs without boar taint. PMID:22247111

Windig, J J; Mulder, H A; Ten Napel, J; Knol, E F; Mathur, P K; Crump, R E

2012-07-01

158

Interpreting force concept inventory scores: Normalized gain and SAT scores  

Directory of Open Access Journals (Sweden)

Full Text Available Preinstruction SAT scores and normalized gains (G on the force concept inventory (FCI were examined for individual students in interactive engagement (IE courses in introductory mechanics at one high school (N=335 and one university (N=292 , and strong, positive correlations were found for both populations ( r=0.57 and r=0.46 , respectively. These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawson’s Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of students’ cognitive skills, as measured either by the SAT or by Lawson’s test. While Lawson’s test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of students’ reasoning abilities. Knowing the students’ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve students’ cognitive level.

Jeffrey J. Steinert

2007-05-01

159

Histological scoring and associated risk factors of non-alcoholic fatty liver disease.  

Science.gov (United States)

Non alcoholic steatohepatitis is a hepatic disorder with histological features of alcohol induced liver disease that occurs in individual who do not consume significant alcohol. Liver biopsy is an important part of the evaluation in term of both grade & stage. A cross sectional study was carried out in the department of Pathology, Dhaka Medical College, Dhaka & department of Hepatology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from July 2007 to June 2009. Total 55 adult subjects of both sex were included on the basis of predefined inclusion & exclusion criteria in this study to evaluate the histological pattern of non alcoholic fatty liver disease (NAFLD) and its correlation with risk factors. Liver biopsy was done and H & E and Masson's Trichrome stain slides were examined to evaluate the grade and stage of NAFLD. Scoring and semiquantitative assessment of steatosis and NAFLD severity was done according to Kleiner scale known as NAFLD activity score (NAS). The results of Pearson correlation showed only BMI and triglyceride level significantly correlated with NAS score. The results of Spearman's rank correlation showed that BMI, central obesity, triglyceridaemia and age significantly correlated with staging of fibrosis. The results of multiple regression analysis showed that variation of NAS depend on BMI and triglyceride level. The study also revealed that risk factors contributed about 29% risk for the occurrence of non alcoholic steatohepatitis. PMID:24292310

Majid, N; Ali, Z; Rahman, M R; Akhter, A; Rajib, R C; Ahmad, F; Sharmin, S; Akond, A K; Huq, N

2013-10-01

160

Reporting Valid and Reliable Overall Scores and Domain Scores  

Science.gov (United States)

In educational assessment, overall scores obtained by simply averaging a number of domain scores are sometimes reported. However, simply averaging the domain scores ignores the fact that different domains have different score points, that scores from those domains are related, and that at different score points the relationship between overall…

Yao, Lihua

2010-01-01

 
 
 
 
161

Cartilage Lesion Score: Comparison of a Quantitative Assessment Score with Established Semiquantitative MR Scoring Systems.  

Science.gov (United States)

Purpose To describe a scoring system for quantification of cartilage lesions (Cartilage Lesion Score [CaLS]), to determine its reproducibility, to examine the association of CaLS-detected longitudinal change with known risk factors for osteoarthritis (OA) progression by comparing a group of subjects with OA risk factors with a group of subjects without OA risk factors, and to compare the CaLS system with the established semiquantitative Whole-Organ Magnetic Resonance Imaging Score (WORMS) and Boston-Leeds Osteoarthritis Knee Score (BLOKS) systems in terms of detection of cartilage defect progression. Materials and Methods All subjects provided written informed consent, and the local institutional review board approved this HIPAA-compliant study. Fifty-two subjects with and 25 subjects without risk factors for knee OA were randomly selected from the Osteoarthritis Initiative. Inclusion criteria were age of 45-60 years, body mass index of 19-27 kg/m(2), and no knee pain or OA on radiographs at baseline. Baseline and 24-month follow-up right knee 3-T magnetic resonance images were analyzed with WORMS, BLOKS, and CaLS systems. Progression of cartilage lesions with each scoring system was compared by using multilevel mixed-effects linear-regression models. ? values were calculated to determine reliability. Results Intraclass coefficient values for inter- and intraobserver reliability of the CaLS system were 0.86 and 0.91, respectively. Interobserver ? value range for individual features was 0.81-0.94. The CaLS system enabled significantly higher detection of cartilage lesion progression than did WORMS or BLOKS systems (P < .001); 51.8% (56 of 108), 17.6% (19 of 108), and 13.0% (14 of 108) of the lesions progressed when analyzed with the CaLS, WORMS, and BLOKS systems, respectively. With the CaLS system, subjects with OA risk factors had significantly higher odds of progression than did subjects without risk factors (odds ratio, 2.78; P = .005). Conclusion The CaLS system is a reproducible scoring system for cartilage lesions that yields an improved detection rate for monitoring progression when compared with detection rates of semiquantitative WORMS and BLOKS systems. © RSNA, 2014. PMID:24475848

Alizai, Hamza; Virayavanich, Warapat; Joseph, Gabby B; Nardo, Lorenzo; Liu, Felix; Liebl, Hans; Nevitt, Michael C; Lynch, John A; McCulloch, Charles E; Link, Thomas M

2014-05-01

162

Introduction to propensity scores.  

Science.gov (United States)

Although randomization provides a gold-standard method of assessing causal relationships, it is not always possible to randomly allocate exposures. Where exposures are not randomized, estimating exposure effects is complicated by confounding. The traditional approach to dealing with confounding is to adjust for measured confounding variables within a regression model for the outcome variable. An alternative approach-propensity scoring-instead fits a regression model to the exposure variable. For a binary exposure, the propensity score is the probability of being exposed, given the measured confounders. These scores can be estimated from the data, for example by fitting a logistic regression model for the exposure including the confounders as explanatory variables and obtaining the estimated propensity scores from the predicted exposure probabilities from this model. These estimated propensity scores can then be used in various ways-matching, stratification, covariate-adjustment or inverse-probability weighting-to obtain estimates of the exposure effect. In this paper, we provide an introduction to propensity score methodology and review its use within respiratory health research. We illustrate propensity score methods by investigating the research question: 'Does personal smoking affect the risk of subsequent asthma?' using data taken from the Tasmanian Longitudinal Health Study. PMID:24889820

Williamson, Elizabeth J; Forbes, Andrew

2014-07-01

163

La evaluación de revistas de psicología: correlación entre el factor de impacto, el índice h y los criterios de Latindex / Assessment of psychology journals: correlation of impact factor and h-index vs. Latindex criteria  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish El objetivo de este trabajo fue comprobar el grado en que dos criterios basados en el recuento de citas, como el factor de impacto propuesto por el Journal Citation Reports y el índice h de Hirsch (2005), y otro criterio más relacionado con la calidad del proceso editorial, como el grado de cumplimi [...] ento de los criterios propuestos por el catálogo Latindex, ordenan de forma similar un conjunto de revistas de psicología. Utilizamos estos tres criterios para confeccionar sendas clasificaciones de estas revistas y encontramos que la correlación entre la clasificación Latindex y cualquiera de las otras dos no fue significativamente distinta de cero. Se discute la conveniencia de disponer de criterios ajenos al recuento de citas para evaluar la calidad de las revistas científicas de psicología y se propone el uso combinado de criterios como la difusión, la internacionalidad, el proceso de revisón de los manuscritos o la política editorial de la revista. Abstract in english The goal of this study is to explore the extent to which several psychology journals may be similarly classified on the basis of citation count through the impact factor proposed by Journal Citation Reports and the hindex (Hirsch, 2005), against a given journal's compliance with the Latindex Catalog [...] ue criteria for assessing editorial quality. Using these parameters, we carried out three separate journal rankings and found that the correlation between the Latindex ranking and either of the former is not statistically distinct from zero. The suitability of applying editorial- rather than citation-based criteria to evaluate the quality of psychology journals is discussed. This discussion proposes using a mix of editorial criteria such as circulation, international reach and the journal's manuscript review process and editorial policies.

Gámez, A. Matías.

164

score-network.org  

... score-network.org 24 February 2014 Consumption opportunities: strategies for change UNEP This paper discusses the strategies, means and ways to make the change to sustainable consumption . 2000 UNEP, Geneva, Switzerland attachment (pdf 629K) ...

165

score-network.org  

...br organization: Pontifícia Universidade Católica do Rio de Janeiro , Arts & Design Department Rua Marquês de São Vicente, 225, Gávea , Rio de Janeiro , Brazil score interest / role: sustainable design, housing, architecture, consumer research ...

166

On Credit Scoring Estimation  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Credit scoring methods became standard tool of banks and other financial institutions, direct marketing retailers and advertising companies to estimate whether an applicant for credit/goods will pay back his liabilities. In this thesis we give a short overview of credit scoring and its methods. We investigate the usage of some of these methods and their performance on a data set from a French bank. Our results indicate that the methods, namely the logistic regression, multi-layer perceptron (...

Komora?d, Karel

2002-01-01

167

Evaluation of Nordic Swan Eco-Labelling Criteria Documents for 8 Groups of Products Containing Surface Active Agents.  

Science.gov (United States)

The investigation assessment 8 Nordic Swan criteria documents for eco-labelling of various product groups containing surface-active agents concerning criteria setting and the scoring procedures of products. This study discusses the criteria documents with...

P. Solyom L. G. Lindfors

1998-01-01

168

Satisfaction in hospitality on TripAdvisor.com: An analysis of the correlation between evaluation criteria and overall satisfaction / A satisfação na hotelaria pelo TripAdvisor: uma análise da correlação entre os critérios de avaliação e satisfação geral  

Scientific Electronic Library Online (English)

Full Text Available SciELO Portugal | Language: English Abstract in portuguese As mídias sociais alteraram a forma dos turistas buscarem e trocarem informações, determinando mudanças gerenciais para as empresas turísticas, incluindo os meios de hospedagem. Os comentários e avaliações de hóspedes têm impactado na reputação das organizações, tanto positivamente como negativament [...] e. Os sítios de conteúdo gerado pelos usuários permitem que estas informações cheguem a outros turistas, através da avaliação do serviço prestado e influenciando na decisão de novos visitantes. Desta forma, esta investigação procurou identificar a correlação entre a satisfação geral e os critérios de avaliação. Para isto, foram analisadas 660 avaliações (236 nos hotéis 03 estrelas, 125 nos hotéis 04 estrelas e 299 nos hotéis 05 estrelas) no Tripadvisor, que continham de forma independente, avaliações sobre: satisfação geral, valor (custo-benefício), localização, qualidade do sono, quartos, limpeza e serviço. Os resultados apontaram para um maior índice de correlação da satisfação geral com os critérios quarto, serviço ofertado e custo-benefício. Abstract in english Social media has changed the way tourists seek and exchange information, resulting in changes in the management of tourism businesses including hospitality facilities. Guest reviews and comments have had an impact on the reputation of organisations, both positive and negative. Websites with user-gen [...] erated content spread this information to other tourists through the evaluation of service provided and thereby influence the decision of new visitors. Accordingly, this research sought to identify the correlation between overall satisfaction and the evaluation criteria used on a website. For this, we analysed 660 reviews (236 of three-star hotels, 125 of four-star hotels and 299 of five-star hotels) on TripAdvisor, containing independent reviews including overall satisfaction, value (cost-benefit), location, sleep quality, rooms, cleanliness and service. Results showed a strong correlation of overall satisfaction with the criteria of room, service provided and cost-benefit.

Pablo Flôres, Limberger; Francisco Antonio dos, Anjos; Jéssica Vieira de Souza, Meira; Sara Joana Gadotti dos, Anjos.

169

Use of allele scores as instrumental variables for Mendelian randomization  

Science.gov (United States)

Background An allele score is a single variable summarizing multiple genetic variants associated with a risk factor. It is calculated as the total number of risk factor-increasing alleles for an individual (unweighted score), or the sum of weights for each allele corresponding to estimated genetic effect sizes (weighted score). An allele score can be used in a Mendelian randomization analysis to estimate the causal effect of the risk factor on an outcome. Methods Data were simulated to investigate the use of allele scores in Mendelian randomization where conventional instrumental variable techniques using multiple genetic variants demonstrate ‘weak instrument’ bias. The robustness of estimates using the allele score to misspecification (for example non-linearity, effect modification) and to violations of the instrumental variable assumptions was assessed. Results Causal estimates using a correctly specified allele score were unbiased with appropriate coverage levels. The estimates were generally robust to misspecification of the allele score, but not to instrumental variable violations, even if the majority of variants in the allele score were valid instruments. Using a weighted rather than an unweighted allele score increased power, but the increase was small when genetic variants had similar effect sizes. Naive use of the data under analysis to choose which variants to include in an allele score, or for deriving weights, resulted in substantial biases. Conclusions Allele scores enable valid causal estimates with large numbers of genetic variants. The stringency of criteria for genetic variants in Mendelian randomization should be maintained for all variants in an allele score.

Burgess, Stephen; Thompson, Simon G

2013-01-01

170

Indirect selection criteria against clean wool colour in Corriedale sheep and their effects on wool production traits  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The potential of greasy wool colour subjective assessment Visual Colour Score (VCS) and the yellow predictive test (YPC) as indirect selection criteria for reduction of clean wool colour (CWC) in Corriedale sheep was examined. The heritability of these wool colour traits and the wool production traits, greasy (GFW) and clean fleece weights (CFW), and mean fibre diameter (MFD) and the phenotypic and genetic correlations among these traits were estimated from a Corriedale flock using AIREML pro...

2002-01-01

171

Malnutrition-Inflammation Score in Hemodialysis Patients  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Malnutrition is a prevalent complication in patients on maintenance hemodialysis. Malnutrition-inflammation score (MIS, comprehensive nutritional assessment tool, as the reference standard was used to examine protein-energy wasting (PEW and inflammation in hemodialysis patients. Materials and Methods: In this descriptive- analytical study, 48 hemodialysis patients were selected with random sampling. All the patients were interviewed and the MIS of the patients was recorded. This new comprehensive Malnutrition-Inflammation Score (MIS which involves 7 components from the SGA and the 3 additional non-SGA components of body mass index, serum albumin, and total iron-binding capacity (TIBC has 10 components, each with four levels of severity, from 0 (normal to 3 (very severe. These scores were compared with anthropometric measurements; laboratory measures. Data was analyzed with Chi-square and t-tests and Pearson correlation coefficiant. Results: In this study 25% of patients on hemodialysis were normal nourished, 54.3% of patients were mild malnourished, 20.8% were moderately malnourished and no one of them were not sever malnurished. Pearson correlation coefficients between MIS score and age (r=+0.332 was significant. There was no correlation between the malnutrition score and sex Chi-square test showed significant correlation between MIS score and dialysis period ?50 months (?²=9.09. Conclusion: In this study, no one of patients has severed malnutrition, and most of them were assigned to the mildly/moderately malnourished rating. On other hand, most of patients are the well-nourished. Correlation between MIS score and age and dialysis period was significant.

Behrooz Ebrahimzadehkor

2014-08-01

172

Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics  

Digital Repository Infrastructure Vision for European Research (DRIVER)

There is critical need for improved biomarker assessment platforms which integrate traditional pathological parameters (TNM stage, grade and ER/PR/HER2 status) with molecular profiling, to better define prognostic subgroups or systemic treatment response. One roadblock is the lack of semi-quantitative methods which reliably measure biomarker expression. Our study assesses reliability of automated immunohistochemistry (IHC) scoring compared to manual scoring of five selected biomarkers in a ti...

Cass, Jamaica D.; Sonal Varma; Day, Andrew G.; Waheed Sangrar; Rajput, Ashish B.; Raptis, Leda H.; Jeremy Squire; Yolanda Madarnas; Sengupta, Sandip K.; Elliott, Bruce E.

2012-01-01

173

Geometric Facial Gender Scoring: Objectivity of Perception  

Science.gov (United States)

Gender score is the cognitive judgement of the degree of masculinity or femininity of a face which is considered to be a continuum. Gender scores have long been used in psychological studies to understand the complex psychosocial relationships between people. Perceptual scores for gender and attractiveness have been employed for quality assessment and planning of cosmetic facial surgery. Various neurological disorders have been linked to the facial structure in general and the facial gender perception in particular. While, subjective gender scoring by human raters has been a tool of choice for psychological studies for many years, the process is both time and resource consuming. In this study, we investigate the geometric features used by the human cognitive system in perceiving the degree of masculinity/femininity of a 3D face. We then propose a mathematical model that can mimic the human gender perception. For our experiments, we obtained 3D face scans of 64 subjects using the 3dMDface scanner. The textureless 3D face scans of the subjects were then observed in different poses and assigned a gender score by 75 raters of a similar background. Our results suggest that the human cognitive system employs a combination of Euclidean and geodesic distances between biologically significant landmarks of the face for gender scoring. We propose a mathematical model that is able to automatically assign an objective gender score to a 3D face with a correlation of up to 0.895 with the human subjective scores.

Gilani, Syed Zulqarnain; Rooney, Kathleen; Shafait, Faisal; Walters, Mark; Mian, Ajmal

2014-01-01

174

Geometric facial gender scoring: objectivity of perception.  

Science.gov (United States)

Gender score is the cognitive judgement of the degree of masculinity or femininity of a face which is considered to be a continuum. Gender scores have long been used in psychological studies to understand the complex psychosocial relationships between people. Perceptual scores for gender and attractiveness have been employed for quality assessment and planning of cosmetic facial surgery. Various neurological disorders have been linked to the facial structure in general and the facial gender perception in particular. While, subjective gender scoring by human raters has been a tool of choice for psychological studies for many years, the process is both time and resource consuming. In this study, we investigate the geometric features used by the human cognitive system in perceiving the degree of masculinity/femininity of a 3D face. We then propose a mathematical model that can mimic the human gender perception. For our experiments, we obtained 3D face scans of 64 subjects using the 3dMDface scanner. The textureless 3D face scans of the subjects were then observed in different poses and assigned a gender score by 75 raters of a similar background. Our results suggest that the human cognitive system employs a combination of Euclidean and geodesic distances between biologically significant landmarks of the face for gender scoring. We propose a mathematical model that is able to automatically assign an objective gender score to a 3D face with a correlation of up to 0.895 with the human subjective scores. PMID:24923319

Gilani, Syed Zulqarnain; Rooney, Kathleen; Shafait, Faisal; Walters, Mark; Mian, Ajmal

2014-01-01

175

Genetic effect on apgar score  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os coeficientes de correlação intraclasse foram calculados para os índices de Apgar 1 e 5 minutos após o nascimento de 604 pares de gêmeos em uma maternidade do sudeste brasileiro, depois que esses índices foram ajustados para idade gestacional e sexo. Os dados obtidos apoiaram a hipótese genética a [...] penas em relação ao primeiro índice de Apgar, provavelmente porque ele é menos influenciado pelo ambiente do que 4 minutos depois, quando os recém-nascidos já estiveram sob os cuidados de uma equipe de neonatologistas. Os gêmeos nascidos em primeiro lugar apresentaram, em média, melhor estado clínico que os nascidos em segundo lugar, visto que os primeiros mostraram uma proporção de índices de Apgar inferiores a 7 significativamente menor do que os nascidos em segundo lugar, tanto um minuto (17,5% contra 29,8%) quanto cinco minutos após o nascimento (7,2% contra 11,9%). A proporção de recém-nascidos com índices de Apgar que indicam bom prognóstico foi significativamente menor nos gêmeos do que em 1.522 conceptos únicos nascidos na mesma maternidade. Índices de Apgar menores do que 7, obtidos um e cinco minutos após o nascimento, foram encontrados respectivamente em 9,2% e em 3,4% dos recém-nascidos de parto único. Abstract in english Intraclass correlation coefficients for one- and five-min Apgar scores of 604 twin pairs born at a southeastern Brazilian hospital were calculated, after adjusting these scores for gestational age and sex. The data support a genetic hypothesis only for 1-min Apgar score, probably because it is less [...] affected by the environment than 4 min later, after the newborns have been under the care of a neonatology team. First-born twins exhibited, on average, better clinical conditions than second-born twins. The former showed a significantly lower proportion of Apgar scores under seven than second-born twins, both at 1 min (17.5% vs. 29.8%) and at 5 min (7.2% vs. 11.9%). The proportion of children born with "good" Apgar scores was significantly smaller among twins than among 1,522 singletons born at the same hospital. Among the latter, 1- and 5-min Apgar scores under seven were exhibited by 9.2% and 3.4% newborns, respectively.

Franchi-Pinto, Carla; Colletto, Glória Maria Duccini Dal; Krieger, Henrique; Beiguelman, Bernardo.

176

Correlation of the Health Sciences Reasoning Test With Student Admission Variables  

Science.gov (United States)

Objectives. To assess the association between scores on the Health Sciences Reasoning Test (HSRT) and pharmacy student admission variables. Methods. During the student admissions process, cognitive data, including undergraduate grade point average and Pharmacy College Admission Test (PCAT) scores, were collected from matriculating doctor of pharmacy (PharmD) students. Between 2007 and 2009, the HSRT was administered to 329 first-year PharmD students. Correlations between HSRT scores and cognitive data, previous degree, and gender were examined. Results. After controlling for other predictors, 3 variables were significantly associated with HSRT scores: percentile rank on the reading comprehension (pPCAT. Conclusions. Scores on the reading comprehension, verbal, and quantitative sections of the PCAT were significantly associated with HSRT scores. Some elements of critical thinking may be measured by these PCAT subsections. However, the HSRT offers information absent in standard cognitive admission criteria.

Persky, Adam; Blalock, Susan J.

2013-01-01

177

Genetic parameters for androstenone, skatole, indole, and human nose scores as measures of boar taint and their relationship with finishing traits  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The purpose of this study was to evaluate measures of boar (Sus scrofa) taint as potential selection criteria to reduce boar taint so that castration of piglets will become unnecessary. Therefore, genetic parameters of boar taint measures and their genetic correlations with finishing traits were estimated. In particular, the usefulness of a human panel assessing boar taint (human nose score) was compared with chemical assessment of boar taint compounds, androstenone, skatole, and indole. Heri...

Windig, J. J.; Mulder, H. A.; Napel, J.; Knol, E. F.; Mathur, P. K.; Crump, R. E.

2012-01-01

178

A Study of Relationships between the CI Scores (E-C of High-score & Low-score Groups and Their Language Learning Strategies  

Directory of Open Access Journals (Sweden)

Full Text Available This paper investigates the relationships between language learning strategies and consecutive interpretation (CI scores (E-C of 120 English major students in China through a quantitative study. The analysis shows that there exist significant differences of using meta-cognitive strategy and cognitive strategy between high-score group and low-score group, sub-CI scores are positively correlated with the two strategies, and meta-cognitive strategy can positively predict the total scores. This indicates that the use of language learning strategies does have an impact on interpreting study.

Jianjun Liu

2011-10-01

179

Introduction of a new standardized assessment score of spine morphology in osteogenesis imperfecta  

International Nuclear Information System (INIS)

Purpose: Osteogenesis imperfecta (OI) is a rare hereditary disease leading to multiple bone deformities and fractures. In the absence of causal therapy, a symptomatic approach is based on treatment with bisphosphonates and physiotherapy. The clinical and radiological manifestations vary. Therefore, standardization and quantification for an objective comparison, especially during therapy, are required. In this paper, radiological changes of the spine are quantified according to their clinical relevance to define a scoring system that transfers the morphological changes into a single value representing the severity of the disease. Materials and Methods: 268 lateral spine X-rays of 95 patients with OI (median age 5.6 years) were assessed. The findings were classified based on their clinical relevance. Results: The three criteria, vertebral compression, thoracolumbar kyphosis and deformity type, were quantified in a new grading system. Based on this, a 'severity classification' (1 to 5) was defined with implications for diagnostics and treatment. A mathematical formula that takes into account the three criteria and their correlations to clinical relevance, resulting in a 'severity score', was developed. Conclusion: 'Severity classification' and 'severity score' introduce a new concept for a standardized evaluation of spine X-rays in patients with OI. For both scientific and routine purposes, it provides the user with a simple and easy-to-handle tool for assessing and comparing different stages of severity prior to and during therapy with detailed accuracy. (orig.)

2012-08-01

180

score-network.org  

... Annukka Berg tel: +358-50-367 4996 annukka.berg@helsinki.fi organization: University of Helsinki , Department of Social Sciences P.O. Box 18 , Helsinki , Finland http://www.helsinki.fi/university/index.html score interest / role: Sustainable consumption governance; roles of citizens and consumers in the formation of sustainable consumption and production policies ...

 
 
 
 
181

score-network.org  

...htm biography: Lean Six Sigma - re-designing business processes for Sustainable Development; Responsible Entrepreneurship for Sustainable Development; Organisational Development for Sustainable Procurement and Consumption with primary focus on Supplier Relationship Management. score interest / role: Would like to engage in exchanges primarily in ...

182

Determining ICH Score: can we go beyond? Determinando o ICH Score: podemos ir além?  

Directory of Open Access Journals (Sweden)

Full Text Available Spontaneous intracerebral hemorrhage (SICH still presents a great heterogeneity in its clinical evaluation, demonstrating differences in the enrollment criteria used for the study of intracerebral hemorrhage (ICH treatment. The aim of the current study was to assess the ICH Score, a simple and reliable scale, determining the 30-day mortality and the one-year functional outcome. Consecutive patients admitted with acute SICH were prospectively included in the study. ICH Scores ranged from 0 to 4, and each increase in the ICH Score was associated with an increase in the 30-day mortality and with a progressive decrease in good functional outcome rates. However, the occurrence of a pyramidal pathway injury was better related to worse functional outcome than the ICH Score. The ICH Score is a good predictor of 30-day mortality and functional outcome, confirming its validity in a different socioeconomic populations. The association of the pyramidal pathway injury as an auxiliary variable provides more accurate information about the prognostic evolution.A hemorragia intracerebral (AVCH espontânea ainda apresenta grande heterogeneidade em sua avaliação clínica, evidenciando diferenças nos critérios de inclusão utilizados nos estudos de tratamento da hemorragia intracerebral (ICH. O objetivo do presente estudo foi avaliar o ICH Score, uma escala simples e confiável, determinando a mortalidade em 30 dias e o resultado funcional após um ano. Pacientes consecutivos com AVCH espontâneo foram incluídos prospectivamente no estudo. O ICH Score variou de 0 a 4 e cada aumento no ICH Score esteve associado com um aumento na mortalidade em 30 dias e com uma progressiva diminuição nas taxas de bom resultado funcional. Entretanto, a ocorrência de injúria da via piramidal esteve melhor relacionada com um pior resultado funcional do que o ICH Score. O ICH Score é um bom preditor de mortalidade em 30 dias e resultado funcional, confirmando sua validade em diferentes populações socioeconômicas. A associação da injúria da via piramidal como variável auxiliar fornece informações mais precisas sobre a evolução prognóstica.

Gustavo Cartaxo Patriota

2009-09-01

183

Calculating a Score of Sustainable Development  

Directory of Open Access Journals (Sweden)

Full Text Available Sustainable development is considered to be one of the most important economic issues today. Sustainable development indicators are taken into account when comparing the countries in terms of the level of development. Besides, these indicators are taken to be a major source of information in deciding the development policies the countries will follow as well as for a wide range of investment decisions. In this study, by using sustainable development indicators, we develop scores of sustainable development for the Commonwealth of Indepen-dent States (CIS, the Baltic Republics (BC and Russia in the context of principal components analysis. Subsequently, the sustainable development scores of the investigated countries and the United Nations Human Development Index (HDI scores were compared, and the relationship between the two was evaluated. The correlation coefficient between the two scores was found to be 0.872 and statistically significant at 1 % level.

Fatih ÇEMREK

2013-12-01

184

Correlation between Teacher Turnover Rates in the State of Alaska and Standardized Test Scores in the Area of Mathematics on the Standards Based Assessments/High School Qualifying Exam  

Science.gov (United States)

This study utilized bivariate correlations, partial correlations, multivariate analysis including Hotelling-T, and observed power to investigate the possible correlations and connections of teacher turnover in Alaska's public school system to performance on the standards-based assessment of the Alaska High School Qualifying Exam (HSQE). The study…

Roehl, Roy F., II

2010-01-01

185

Developing Scoring Algorithms  

Science.gov (United States)

We developed scoring procedures to convert screener responses to estimates of individual dietary intake for fruits and vegetables (cup equivalents), dairy (cup equivalents), added sugars (tsp), whole grains (ounce equivalents), fiber (g), and calcium (mg) using the What We Eat in America 24-hour dietary recall data from the 2003-2006 NHANES. The following equations were estimated in the NHANES 2003-2006, using SAS PROC REG.

186

Coronary artery calcium scoring.  

Science.gov (United States)

Numerous clinical studies have shown that coronary artery calcium scoring provides substantial incremental risk prediction beyond conventional coronary risk factors for coronary heart disease events. About half of all patients with coronary artery disease (CAD) present initially with unexpected myocardial infarction or sudden death. Early identification of this subgroup of patients is vital for institution of intensive, early preventive measures to decrease morbidity and mortality due to CAD. PMID:21796088

Mehra, Sanjay; Movahed, Hossein; Movahed, Assad

2011-01-01

187

Criterios ecográficos diagnósticos de neoplasia maligna en el nódulo tiroideo: correlación con la punción por aspiración con aguja fina y la anatomía patológica Ultrasound diagnostic criteria of malignancy in a thyroid nodule: correlation with fine needle aspiration and pathology  

Directory of Open Access Journals (Sweden)

Full Text Available Introducción. La ecografía de tiroides ha mejorado la certeza diagnóstica para neoplasia maligna del nódulo tiroideo. Es importante definir qué nódulos requieren biopsia por aspiración con aguja fina (BACAF para disminuir el costo de un procedimiento innecesario y evitar que pase inadvertido el diagnóstico de neoplasia maligna. Objetivo. Validar los criterios ecográficos de neoplasia maligna que indican la punción por aspiración con aguja fina de tiroides. Materiales y métodos. Se diseñó un estudio prospectivo a tres años para evaluar la concordancia entre los hallazgos ecográficos y la punción por aspiración con aguja fina de tiroides comparada con el estudio final de histopatología. Se evaluó la sensibilidad, la especificidad, el valor diagnóstico positivo y negativo, la concordancia medida por el coeficiente kappa y el coeficiente de correlación. Resultados. Se estudiaron 1.467 pacientes, 10,2 % hombres y 89,8 % mujeres, con edades entre los 10 y los 95 años; el tamaño promedio del nódulo fue de 16 mm. Un total de 623 requirieron tiroidectomía; al resto se les hizo seguimiento por ecografía. Se presentaron 269 carcinomas papilares, 14 foliculares, 4 indiferenciados, 159 bocios, 74 adenomas y 101 tiroiditis. Se obtuvo sensibilidad de 86,4 %, especificidad de 89,4 %, valor diagnóstico de un resultado positivo de 87,5 % y uno negativo de 84,1 %. Los hallazgos ecográficos relacionados con cáncer fueron: hipoecogenicidad, microcalcificaciones, papilas y flujo intranodular. Individualmente, la concordancia fue baja, pero con la combinación de hipoecogenicidad, microcalcificaciones y papilas fue media y, con la adición de aumento del flujo intranodular, resultó alta. Conclusiones. La combinación de hipoecogenicidad, microcalcificaciones, papilas y alto flujo intranodular tiene alta concordancia con neoplasia maligna; sin embargo, cada criterio por separado no la tiene, y no pueden usarse individualmente para predecir o descartar neoplasia maligna.Introduction. Thyroid ultrasound has improved the diagnostic accuracy in the diagnosis of malignant neoplasia in thyroid nodules. It is important to define which nodules require fine needle aspiration so as to diminish the costs of unnecessary procedures and at the same time avoid unnoticed malignancy. Objective. To validate the echographic criteria of malignant neoplasia that validate fine needle aspiration of the thyroid nodule. Material and methods. Three-year prospective study to assess correlation between the ultrasound findings and fine needle aspiration with pathology findings, including sensibility, specificity, positive predictive value, negative predictive value, and concordance measured by Kappa coefficient, and correlation coefficient. Results. The study included 1,467 patients, 10,2% males and 89,8% females, with ages ranging from 10 years to 95 years; average size of the nodule was 16 mm; 623 patients required thyroidectomy, while the remainder were followed by ultrasound. There were 269 papillary carcinomas, 14 follicular carcinomas, 4 anaplastic carcinomas, 159 goiters, 74 adenomas, and 101 thyroiditis. Sensibility was 86,4%, specificity was 89,4%, positive predictive value 87,5%, and negative predictive value 84,1%. Ultrasound findings related with cancer were hypoechogenicity, microcalcifications, papillae, and intranodal flow; when adding intranodal flow, concordance was high. Conclusions. The combination of hypoechogenicity, microcalcifications, papillae and high intranodal flow exhibit high concordance with malignancy; however, echographic criteria considered individually does not, and those individual criteria cannot be used to predict or rule out malignant neoplasia.

Andrés Ignacio Chala

2013-03-01

188

Description and validation of a scoring system for tomosynthesis in pulmonary cystic fibrosis  

Energy Technology Data Exchange (ETDEWEB)

To design and validate a scoring system for tomosynthesis (digital tomography) in pulmonary cystic fibrosis. A scoring system dedicated to tomosynthesis in pulmonary cystic fibrosis was designed. Three radiologists independently scored 88 pairs of radiographs and tomosynthesis examinations of the chest in 60 patients with cystic fibrosis and 7 oncology patients. Radiographs were scored according to the Brasfield scoring system and tomosynthesis examinations were scored using the new scoring system. Observer agreements for the tomosynthesis score were almost perfect for the total score with square-weighted kappa >0.90, and generally substantial to almost perfect for subscores. Correlation between the tomosynthesis score and the Brasfield score was good for the three observers (Kendall's rank correlation tau 0.68, 0.77 and 0.78). Tomosynthesis was generally scored higher as a percentage of the maximum score. Observer agreements for the total score for Brasfield score were almost perfect (square-weighted kappa 0.80, 0.81 and 0.85). The tomosynthesis scoring system seems robust and correlates well with the Brasfield score. Compared with radiography, tomosynthesis is more sensitive to cystic fibrosis changes, especially bronchiectasis and mucus plugging, and the new tomosynthesis scoring system offers the possibility of more detailed and accurate scoring of disease severity. (orig.)

Vult von Steyern, Kristina; Bjoerkman-Burtscher, Isabella M.; Bozovic, Gracijela; Wiklund, Marie; Geijer, Mats [Skaane University Hospital, Lund University, Centre for Medical Imaging and Physiology, Lund (Sweden); Hoeglund, Peter [Skaane University Hospital, Competence Centre for Clinical Research, Lund (Sweden)

2012-12-15

189

Description and validation of a scoring system for tomosynthesis in pulmonary cystic fibrosis  

International Nuclear Information System (INIS)

To design and validate a scoring system for tomosynthesis (digital tomography) in pulmonary cystic fibrosis. A scoring system dedicated to tomosynthesis in pulmonary cystic fibrosis was designed. Three radiologists independently scored 88 pairs of radiographs and tomosynthesis examinations of the chest in 60 patients with cystic fibrosis and 7 oncology patients. Radiographs were scored according to the Brasfield scoring system and tomosynthesis examinations were scored using the new scoring system. Observer agreements for the tomosynthesis score were almost perfect for the total score with square-weighted kappa >0.90, and generally substantial to almost perfect for subscores. Correlation between the tomosynthesis score and the Brasfield score was good for the three observers (Kendall's rank correlation tau 0.68, 0.77 and 0.78). Tomosynthesis was generally scored higher as a percentage of the maximum score. Observer agreements for the total score for Brasfield score were almost perfect (square-weighted kappa 0.80, 0.81 and 0.85). The tomosynthesis scoring system seems robust and correlates well with the Brasfield score. Compared with radiography, tomosynthesis is more sensitive to cystic fibrosis changes, especially bronchiectasis and mucus plugging, and the new tomosynthesis scoring system offers the possibility of more detailed and accurate scoring of disease severity. (orig.)

2012-12-01

190

The Relationship between Odour Annoyance Scores and Modelled Ambient Air Pollution in Sarnia, “Chemical Valley”, Ontario  

Directory of Open Access Journals (Sweden)

Full Text Available This study aimed at establishing the relationship between annoyance scores and modelled air pollution in “Chemical Valley”, Sarnia, Ontario (Canada. Annoyance scores were taken from a community health survey (N = 774; and respondents’ exposure to nitrogen dioxide (NO2 and sulphur dioxide (SO2 were estimated using land use regression (LUR models. The associations were examined by univariate analysis while multivariate logistic regression was used to examine the determinants of odour annoyance. The results showed that odour annoyance was significantly correlated to modelled pollutants at the individual (NO2, r = 0.15; SO2, r = 0.13 and census tract (NO2, r = 0.56; SO2, r = 0.67 levels. The exposure-response relationships show that residents of Sarnia react to very low pollution concentrations levels even if they are within the Ontario ambient air quality criteria. The study found that exposure to high NO2 and SO2 concentrations, gender, and perception of health effects were significant determinants of individual odour annoyance reporting. The observed association between odour annoyance and modelled ambient pollution suggest that individual and census tract level annoyance scores may serve as proxies for air quality in exposed communities because they capture the within area spatial variability of pollution. However, questionnaire-based odour annoyance scores need to be validated longitudinally and across different scales if they are to be adopted for use at the national level.

Dominic Odwa Atari

2009-10-01

191

score-network.org  

...uk organization: Nottingham Trent University Burton Street , Nottingham , UK biography: From a background in Design and Fine Art, Tom Fisher`s research interests are in human/ object relationships in a range of settings from the materiality of everyday objects to the immateriality of musical performance. His research has concentrated on the role that materials play in everyday experiences with objects and this has informed work on the reuse of packaging (... score interest / role: Tom Fisher`s interest in sustainable consumption centres on the intersection of cultural values, social relationships and materiality in everyday routines. Opportunities to change routines and to modify their environmental impact can only derive from understanding such interesections. ...

192

score-network.org  

...uk biography: London CRN is a network of voluntary and community groups, social enterprises and determined citizens who tackle waste by creating recycling ...organisations in London, and are co-founders of the UK Reconomy partnership incorporating CRN UK, Furniture Reuse Network, Community Composting Network, Cylch ...and CRN Scotland. Members of the network provide services in waste prevention, recycling, reuse and reprocessing and related activities. Services ... London CRN is a UK registered charity and a company limited by guarantee. score interest / role: We recognise that ...

193

PA-Score (Preliminary Assessment Score), Version 2.1.  

Science.gov (United States)

The PA-Score computer program has been developed to assist Superfund site assessment investigations in the Hazard Ranking System (HRS) at the Preliminary Assessment stage of site scoring. The Preliminary Assessment is used to assess the relative threat as...

1992-01-01

194

Validating MMI scores: are we measuring multiple attributes?  

Science.gov (United States)

The multiple mini-interview (MMI) used in health professional schools' admission processes is reported to assess multiple non-cognitive constructs such as ethical reasoning, oral communication, or problem evaluation. Though validation studies have been performed with total MMI scores, there is a paucity of information regarding how well MMI scores differentiate the constructs being measured, the relationship between MMI scores (construct or total) and personality characteristics, and how well MMI scores (construct or total) predict future performance in practice. Results from these studies could assist with MMI station development, rater training, score interpretation, and resource allocation. The purpose of this study was to investigate the validity of MMI construct scores (oral communication and problem evaluation), and their relationship to personality measures (emotionality and extraversion) and specific scores from standardized clinical communications interviews (building the relationship and explaining and planning). Confirmatory factor analysis results support a two factor MMI model, however the correlation between these factors was .87. Oral communication MMI scores significantly correlated with extraversion (r c  = .25, p < .05), but MMI scores were not related to emotionality. Scores for building a relationship were significantly related to MMI oral communication scores, (r c  = .46, p < .001) and problem evaluation scores (r c  = .43, p < .001); scores for explaining and planning were significantly related to MMI problem evaluation scores (r c  = .36, p < .01). The results provide validity evidence for assessing multiple non-cognitive attributes during the MMI process and reinforce the importance of developing MMI stations and scoring rubrics for attributes identified as important for future success in school and practice. PMID:24449121

Oliver, Tom; Hecker, Kent; Hausdorf, Peter A; Conlon, Peter

2014-08-01

195

Relationship of Apgar Scores and Bayley Mental and Motor Scores  

Science.gov (United States)

Examined the relationship of newborns' 1-minute Apgar scores to their 8-month Bayley mental and motor scores and to 8-month classifications of their development as normal, suspect, or abnormal. Also investigated relationships between Apgar scores and race, longevity, and birth weight. (JMB)

Serunian, Sally A.; Broman, Sarah H.

1975-01-01

196

SCORE: A Score-Based Memory Cache Replacement Policy  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We propose SCORE, a novel adaptive cache replacement policy, which uses a score system to select a cache line to replace. Results show that SCORE o®ers low over-all miss rates on SPEC CPU2006 benchmarks, and provides an average IPC that is 4.9% higher than LRU and 7.4% higher than LIP.

Duong, Nam; Cammarota, Rosario; Zhao, Dali; Kim, Taesu; Veidenbaum, Alex

2010-01-01

197

Association of Apgar scores with death and neurologic disability  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Apgar score was devised with the aim to standardize the assessment of newborns. It has been used worldwide to evaluate infants’ condition immediately after birth, to determine their need for resuscitation, and to evaluate the effectiveness of resuscitation. Apgar score was never intended for prediction of outcome beyond the immediate postnatal period; however, since low scores correlate with prenatal and perinatal adversities, multiple studies have examined the relation between the value of...

2009-01-01

198

Prognostic criteria in acute pancreatitis: importance of assessment of pancreatic necrosis by contrast-enhanced CT  

International Nuclear Information System (INIS)

To compare the value of the clinical criteria of Ranson, the classical tomographic criteria of Balthzar and the severity of illness index according to CT in predicting the development of complications of acute pancreatitis. A retrospective study was performed in 100 patients with clinical and analytical evidence of acute pancreatitis. All patients were assessed according to Ranson score at admission and 48 hours later, and contrast-enhanced abdominal CT was carried out. The tomographic images were analyzed on the basis of the classical criteria of Balthazar and the new CT severity of illness index, which includes the assessment of pancreatic necrosis, identified as the areas of the pancreas that are not enhanced by the administration of the contrast material. These three criteria were then correlated with onset of medical and surgical implications. Our findings show that, of the three criteria analyzed, the CT severity of illness index presents the greatest specificity, sensitivity and positive and negative predictive values in the prediction of complications of acute pancreatitis. We conclude that the inclusion of pancreatic necrosis in the tomographic study improves the early assessment of the prognosis of acute pancreatitis. (Author) 20 refs

1997-01-01

199

CT findings score for differentiating adrenal tumours in patients with extra-adrenal malignomas; Computertomographischer Befundungscore zur Differenzierung von Nebennierentumoren bei Patienten mit extraadrenalen Malignomen  

Energy Technology Data Exchange (ETDEWEB)

Purpose: In a retrospective study the diagnostic accuracy of computed tomography for the differentiation of benign from malignant adrenal masses in patients with extra-adrenal malignancies was evaluated. For this differentiation a new score system was tested. Patients and methods: Size, density, structure, and borders of adrenal masses in 60 patients with extra-adrenal tumours were analysed and scored. The single criteria and the total score values were correlated with the final diagnosis achieved either by histology or by follow-up CT examinations. Results: Score values above 4 indicated always metastases and score values below 2 were benign lesions. An overlap occurred at score values between 2 and 3 resulting in an overall accuracy of 83,3%. Conclusion: Single CT criteria are not reliable enough to differentiate benign from malignant adrenal lesions; better results are achieved by using our scoring system. (orig.) [Deutsch] Ziel: Im Rahmen einer retrospektiven Studie wurde die diagnostische Zuverlaessigkeit der Computertomographie bei Patienten mit extraadrenaler maligner Grunderkrankung ueberprueft. Methoden: 60 Patienten mit extraadrenalen Neoplasien wiesen in der Computertomographie eine nodulaere oder diffuse Nebennierenvergroesserung ueber 1 cm als Studieneingangskriterien auf. Groesse, Dichte, Binnenstruktur und Begrenzung sowie Ein- oder Doppelseitigkeit wurden beurteilt und mit Hilfe eines Bewertungssystems (Score) quantifiziert. Einzelkriterien und Gesamtscore pro Patient wurden mit den histologischen oder durch den Verlauf gesicherten Enddiagnosen in Beziehung gesetzt und auf ihre diagnostische Aussagefaehigkeit hin analysiert. Ergebnisse: Eine ausreichende Differenzierung benigner von malignen Nebennierenvergroesserungen war auf der Basis von Einzelkriterien nicht moeglich. Eine deutlich bessere Trennung gelang mit dem von uns entwickelten Scoresystem. Ab einem Gesamtscorewert von 4 waren alle Laesionen Metastasen, unterhalb von 2 lagen nur benigne Veraenderungen vor. Ueberlappungen lagen bei Scorewerten von 2 und 3 vor, dies resultierte in einer Treffsicherheit von 83,3%. Schlussfolgerung: Die semiquantitative Beschreibung in Form eines Gesamtscores von computertomographisch erfassten Morphologie- und Dichtekriterien verbessert die Zuverlaessigkeit der Differenzierung benigner von malignen Nebennierenvergroesserungen gegenueber der Beurteilung aufgrund von Einzelkriterien allein. (orig.)

Gufler, H. [Freiburg Univ. (Germany). Abt. Roentgendiagnostik; Buitrago-Tellez, C.H. [Freiburg Univ. (Germany). Abt. Roentgendiagnostik; Laubenberger, J. [Freiburg Univ. (Germany). Abt. Roentgendiagnostik; Tanyue, M.O. [Freiburg Univ. (Germany). Abt. Roentgendiagnostik; Mundinger, A. [Freiburg Univ. (Germany). Abt. Roentgendiagnostik

1996-08-01

200

score-network.org  

...score-network.org 24 February 2014 researchers members ALEXANDRA LEKKA Museum Educator-Environmental Education officer contact: MA Arch., Phd cand Alexandra LEKKA tel: **2103245750 fax: **2103238425 vagabondlox@yahoo.gr organization: Hellenic Ministry for National Education , Department for Environmental nad Health Education 15 Ermou str.,bureau 408 , 10586 , GR Athens , Greece http:...this agenda a series of projects and activities are designed and expected to be implemented at a nationwide level concernind primary and secondary education groups in collaboration with the Centers for Environmental Education, a educational regional stucture of 56 units throughout the country. All research work and experience is considered valuable in this frame, aiming to participate and exchange with colleagues and countries form various backgrounds. ...

 
 
 
 
201

Ultrasonography-guided percutaneous radiofrequency ablation of hepatocellular carcinomas: A feasibility scoring system for planning sonography  

Energy Technology Data Exchange (ETDEWEB)

Purpose: This study was designed to evaluate whether a feasibility scoring system for planning sonography is a reliable predictor of a safe and complete ablation in ultrasonography (US)-guided percutaneous radiofrequency ablation (RFA) of hepatocellular carcinomas (HCCs). Materials and methods: We retrospectively evaluated the therapeutic outcomes of 108 consecutive patients (M:F, 78:30; mean age, 57.4 years) with a single nodular HCC (mean diameter, 2.0 cm) treated by percutaneous RFA. All patients were assessed for the feasibility of performing an RFA at planning sonography prior to the ablation. The feasibility scoring system consisted of five categories: the safe electrode path (P); the vital organs adjacent to the RFA zone (O); tumor size (S); tumor conspicuity (C); and the heat-sink effect (H). Each category was divided into a four-point scale [1-4]. If a score of 4 in any category was determined, the patient was not considered to be a suitable candidate for percutaneous RFA. We assessed if the score of each category, safety score (P + O), and curability score (S + C + H) correlated with a safe and complete ablation using the chi-squared test and likelihood ratio test for trend. Results: The technical success rate was 100% (108/108) based on CT images obtained immediately after ablation. There was no 30-day mortality after RFA. There were major complications (one case of severe vasovagal reflex, one case of hemoperitoneum and one case of a pseudoaneurysm) in three (2.7%) patients, and minor complications (one case of a biloma, one case of subsegmental infarction and one case of abscess) in three (2.7%) patients. Post-ablation syndrome as a side effect was noted in 38 (35.1%) of 108 patients. The primary technique effectiveness rate at 1 month was 95.1% (105/108). Local tumor progression was noted in eight (7.6%) of 105 patients during the follow-up period (range, 3.0-11.5 months; median, 5.8 months; mean, 5.7 months). There was no significant single category to predict complication and local tumor progression (Fisher's exact test, p > 0.05). Contrary to the safety score for the probability of complication (p > 0.05), the curability score was significantly associated with the probability of local tumor progression (likelihood ratio test for trend; p = 0.03). Conclusion: The new feasibility scoring system for planning US can be used as objective criteria to predict therapeutic efficacy rather than the safety of percutaneous RFA of an HCC.

Rhim, Hyunchul, E-mail: rhimhc@skku.ed [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Choi, Dongil; Kim, Young-sun; Lim, Hyo K. [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Choe, Bong-Keun [Department of Preventive Medicine, Kyung Hee University School of Medicine, Seoul (Korea, Republic of)

2010-08-15

202

Association between scores in high school, aptitude and achievement exams and early performance in health science college.  

Science.gov (United States)

This retrospective study was carried out to assess the correlation between admission criteria to health science colleges, namely, final high school grade and Saudi National Aptitude and Achievement exams, and early academic performance in these colleges. The study included 91 male students studying in the two-year pre-professional program at the King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia. Records of these students were used to extract relevant information and their academic performance (based on the grade point average achieved at the end of the first semester of the pre-professional program), which were analytically studied. Pearson correlation coefficient was used to assess the associations between the different scores. SPSS statistical program (version 12.0) was used for data analyses. We found a strong correlation between the academic performance and the Achievement Exam, Aptitude Exam and high school final grade, with Pearson Correlation Coefficients of 0.96, 0.93, 0.87, respectively. The Saudi National Achievement Exam showed the most significant correlation. Our results indicate that academic performance showed good correlation with the admission criteria used, namely final high school grade, Saudi National Aptitude and Achievement Exams. PMID:19414949

Al-Alwan, Ibrahim A

2009-05-01

203

Association between scores in high school, aptitude and achievement exams and early performance in health science college  

Directory of Open Access Journals (Sweden)

Full Text Available This retrospective study was carried out to assess the correlation between admi-ssion criteria to health science colleges, namely, final high school grade and Saudi National Apti-tude and Achievement exams, and early academic performance in these colleges. The study inclu-ded 91 male students studying in the two-year pre-professional program at the King Saud bin Abdulaziz University for Health Sciences (KSAU-HS, Riyadh, Saudi Arabia. Records of these students were used to extract relevant information and their academic performance (based on the grade point average achieved at the end of the first semester of the pre-professional program, which were analytically studied. Pearson correlation coefficient was used to assess the associa-tions between the different scores. SPSS statistical program (version 12.0 was used for data ana-lyses. We found a strong correlation between the academic performance and the Achievement Exam, Aptitude Exam and high school final grade, with Pearson Correlation Coefficients of 0.96, 0.93, 0.87, respectively. The Saudi National Achievement Exam showed the most significant correla-tion. Our results indicate that academic performance showed good correlation with the admission criteria used, namely final high school grade, Saudi National Aptitude and Achievement Exams.

Al-Alwan Ibrahim

2009-01-01

204

Night cough counts and diary card scores in asthma.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A tape recording system for recording night cough in asthmatics at home is described. Objective cough counts and half hour periods containing cough did not correlate with diary card scores awarded to eight children on seven nights each. Night cough diary scores may mislead in the assessment of symptom severity.

1985-01-01

205

Research-tested Intervention Programs: About Program Scores  

Science.gov (United States)

About RTIPs Scores This site provides a consumer-reports-like list of programs that have been reviewed by a panel of topic experts in the field. Programs are rated on 3 criteria which include the following: research integrity, intervention impact, and

206

Local Observed-Score Equating with Anchor-Test Designs  

Science.gov (United States)

For traditional methods of observed-score equating with anchor-test designs, such as chain and poststratification equating, it is difficult to satisfy the criteria of equity and population invariance. Their equatings are therefore likely to be biased. The bias in these methods was evaluated against a simple local equating method in which the…

van der Linden, Wim J.; Wiberg, Marie

2010-01-01

207

Important Notice: Merit Review Criteria  

Science.gov (United States)

... GRANTEE ORGANIZATIONS Subject: Merit Review Criteria Merit review is a critical component of the ... Attachment NSF MERIT REVIEW CRITERIA NSF merit review criteria are listed below. Following each ...

208

Disease activity score in rheumatoid arthritis with or without secondary fibromyalgia  

International Nuclear Information System (INIS)

Objective: To correlate disease activity score (DAS-28) in the patients with rheumatoid arthritis (RA) with and without secondary fibromyalgia. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Rheumatology, Pakistan Institute of Medical Sciences, Islamabad, from November 2011 to April 2012. Methodology: Patients aged above 16 years diagnosed to have rheumatoid arthritis according to ACR/EULAR criteria 2010 were included in the study. Fibromyalgia (FM) was diagnosed by ACR 1990 criteria. Patients of other autoimmune diseases or psychiatric illnesses were excluded. DAS was determined and compared using t-test with significance at p < 0.05. Results: The mean age of study subjects was 42.9 years. Thirty one out of total 138 patients had fibromyalgia (22.4%). Female gender was predominant (92.0%); being 96.8% in patients with and in 88.2% without fibromyalgia. The average DAS score was high (5.3 + 1.5) in fibromyalgia patients compared to those without fibromyalgia (3.9 + 1.2); this difference in mean value was statistically significant (p = < 0.001). Conclusion: DAS-28 is a useful tool for assessing rheumatoid arthritis disease status in outpatient setting, however, increased disease activity must be assessed for possible co-existence of fibromyalgia which can spuriously give high DAS value and adversely affect treatment decision. (author)

2013-06-01

209

Environmental risk evaluation criteria  

DEFF Research Database (Denmark)

This paper describes an approach to incorporating environmental risk evaluation criteria within IMOâ??s guidelines for Formal Safety Assessment (FSA). Such criteria are currently absent from FSA, and the discussion to include them has just started. Said criteria are relevant for evaluating on a cost-benefit basis Risk Control Options (RCOs) for reducing oil spill pollution risk. Oil pollution may comefrom any ship, including bunker spills from non-tank vessels. RCOs are not necessarily ship-based, and may include vessel traffic management information systems (VTMIS) and other options. The proposed approach may be useful in extending FSA to cover environmental risk evaluation criteria and combines such criteria with criteria already in use in FSA. It can also readily be extended to environmental consequences other than oil pollution. Recent IMO developments on this matter are also reported.

Psaraftis, Harilaos N.

2008-01-01

210

Pediatric appendicitis score: A retrospective analysis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Aims: Evaluation of the pediatric appendicitis score (PAS), in all patients who had an appendicectomy over a one-year period. Methods: Retrospective study of 56 patients aged 4-15 years, who underwent an emergency appendicectomy. PAS was applied and patients were divided according to the PAS protocol into high probability and low probability groups. These results were then correlated with histology. Results: The PAS had sensitivity 0.87, specificity 0.59, positive pr...

Goulder F; Simpson T

2008-01-01

211

Rethinking Convenience Sampling: Defining Quality Criteria  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Convenience sampling is one of the most commonly used sampling procedures in second language acquisition studies, but this non-random sampling procedure suffers from a lot of problems including the inability of controlling for initial differences between experimental and control groups. The present study tries to introduce conditions and criteria which enable researchers to account for these drawbacks and at the same time make validity claims. Individual scores and group statistics are compar...

Farahman Farrokhi; Asgar Mahmoudi-Hamidabad

2012-01-01

212

Determining ICH Score: can we go beyond? / Determinando o ICH Score: podemos ir além?  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese A hemorragia intracerebral (AVCH) espontânea ainda apresenta grande heterogeneidade em sua avaliação clínica, evidenciando diferenças nos critérios de inclusão utilizados nos estudos de tratamento da hemorragia intracerebral (ICH). O objetivo do presente estudo foi avaliar o ICH Score, uma escala si [...] mples e confiável, determinando a mortalidade em 30 dias e o resultado funcional após um ano. Pacientes consecutivos com AVCH espontâneo foram incluídos prospectivamente no estudo. O ICH Score variou de 0 a 4 e cada aumento no ICH Score esteve associado com um aumento na mortalidade em 30 dias e com uma progressiva diminuição nas taxas de bom resultado funcional. Entretanto, a ocorrência de injúria da via piramidal esteve melhor relacionada com um pior resultado funcional do que o ICH Score. O ICH Score é um bom preditor de mortalidade em 30 dias e resultado funcional, confirmando sua validade em diferentes populações socioeconômicas. A associação da injúria da via piramidal como variável auxiliar fornece informações mais precisas sobre a evolução prognóstica. Abstract in english Spontaneous intracerebral hemorrhage (SICH) still presents a great heterogeneity in its clinical evaluation, demonstrating differences in the enrollment criteria used for the study of intracerebral hemorrhage (ICH) treatment. The aim of the current study was to assess the ICH Score, a simple and rel [...] iable scale, determining the 30-day mortality and the one-year functional outcome. Consecutive patients admitted with acute SICH were prospectively included in the study. ICH Scores ranged from 0 to 4, and each increase in the ICH Score was associated with an increase in the 30-day mortality and with a progressive decrease in good functional outcome rates. However, the occurrence of a pyramidal pathway injury was better related to worse functional outcome than the ICH Score. The ICH Score is a good predictor of 30-day mortality and functional outcome, confirming its validity in a different socioeconomic populations. The association of the pyramidal pathway injury as an auxiliary variable provides more accurate information about the prognostic evolution.

Gustavo Cartaxo, Patriota; João Manoel da, Silva-Júnior; Alécio Cristino Evangelista Santos, Barcellos; Joaquim Barbosa de Sousa, Silva Júnior; Diogo Oliveira, Toledo; Fernando Campos Gomes, Pinto; José Marcus, Rotta.

213

On tolerant or intolerant character of interacting criteria in aggregation by the Choquet integral  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In many multi-criteria decision making problems the criteria present some interaction whose nature may vary from one situation to another. When a criterion bounds the global score from above, it is called a veto, due to its rather intolerant character. When it bounds the global score from below, it is then called a favor. In this paper we investigate the tolerance of criteria, or equivalently, the tolerance of the weighted aggregation operator (here the Choquet integral) which is used to aggr...

Marichal, Jean-luc

2003-01-01

214

Cumulative selection and genetic change for weaning or yearling weight or for yearling weight plus muscle score in Hereford cattle.  

Science.gov (United States)

Selection in three lines of Hereford cattle for 1) weaning weight (WWL), 2) yearling weight (YWL), and 3) an index of yearling weight and muscle score (IXL) was studied. Remnant foundation cows and semen from seven foundation sires were used to establish an unselected control line for the last 11 yr of the experiment. Performance data collected over a 23-yr period on birth weight (BWT), weaning weight (WWT), postweaning gain (PWG), yearling weight (YWT), muscle score (MSC), and an index (IDX) giving equal weight to standard deviations of yearling weight and muscle score were analyzed. Generation interval of midparents was about 4.16 yr in each selected line. Sire and dam selection differentials, in standard deviation units per generation, for primary criteria were, respectively, 1.59 and .33 for WWT in WWL, 1.75 and .25 for YWT in YWL, and 1.42 and .25 for IDX in IXL. Components of direct and maternal genetic variances, direct-maternal covariance, and dam permanent environmental variance were estimated by REML. The average annual response of males and females in actual units for each trait in WWL, YWL, and IXL was, respectively, BWT, .22, .24, and .27 kg; WWT, .98, .63, and 1.26 kg; YWT, 2.43, 2.64, and 3.44 kg; and MSC, .053, .009, and .104 scores. Average selection responses in BWT, WWT, YWT, MSC, and IDX per unit of primary criteria in each selection line (all in standard deviation units) were .22, .20, .31, .10, and .24 for WWT in WWL; .23, .12, .32, .04, and .21 for YWT in YWL; and .27, .22, .40, .20, and .36 for IDX in IXL. Responses in bold type are realized heritability and others are correlated responses. Realized genetic correlations were .78 for WWT and YWT, .87 for WWT and IDX, and .86 for YWT and IDX. Responses for all traits in IXL were greater than in other selected lines. PMID:8014151

Koch, R M; Cundiff, L V; Gregory, K E

1994-04-01

215

Beyond Behavioral Objectives: Criteria.  

Science.gov (United States)

The presentation addresses ways in which appropriate criteria for behavioral objectives with the severely handicapped are developed. Two kinds of criteria--those that established specified units and those that provide a standard to determine when the student has completed work on a specific objective--are identified. Specific considerations in…

Sobsey, Dick

216

Plutonium storage criteria  

Energy Technology Data Exchange (ETDEWEB)

The Department of Energy has issued a technical standard for long-term (>50 years) storage and will soon issue a criteria document for interim (<20 years) storage of plutonium materials. The long-term technical standard, {open_quotes}Criteria for Safe Storage of Plutonium Metals and Oxides,{close_quotes} addresses the requirements for storing metals and oxides with greater than 50 wt % plutonium. It calls for a standardized package that meets both off-site transportation requirements, as well as remote handling requirements from future storage facilities. The interim criteria document, {open_quotes}Criteria for Interim Safe Storage of Plutonium-Bearing Solid Materials{close_quotes}, addresses requirements for storing materials with less than 50 wt% plutonium. The interim criteria document assumes the materials will be stored on existing sites, and existing facilities and equipment will be used for repackaging to improve the margin of safety.

Chung, D. [Scientech, Inc., Germantown, MD (United States); Ascanio, X. [Dept. of Energy, Germantown, MD (United States)

1996-05-01

217

Ligand Identification Scoring Algorithm (LISA)  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A central problem in de novo drug design is determining the binding affinity of a ligand with a receptor. A new scoring algorithm is presented that estimates the binding affinity of a protein-ligand complex given a three-dimensional structure. The method, LISA (Ligand Identification Scoring Algorithm), uses an empirical scoring function to describe the binding free energy. Interaction terms have been designed to account for van der Waals (VDW) contacts, hydrogen bonding, desolvation effects a...

Zheng, Zheng; Merz, Kenneth M.

2011-01-01

218

Propensity score matching in SPSS  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Propensity score matching is a tool for causal inference in non-randomized studies that allows for conditioning on large sets of covariates. The use of propensity scores in the social sciences is currently experiencing a tremendous increase; however it is far from a commonly used tool. One impediment towards a more wide-spread use of propensity score methods is the reliance on specialized software, because many social scientists still use SPSS as their main analysis tool. Th...

Thoemmes, Felix

2012-01-01

219

Scores on field independence and performance in snooker.  

Science.gov (United States)

The purpose of this study was to compare the scores on the Group Embedded Figures Test, a measure of field dependence, for 25 male intermediate-level snooker players with scores of 25 intermediate-level sportsmen engaged in soccer, rugby, field hockey, and tennis and to examine the relation between scores on field dependence and performance on a snooker decision-making test. All the snooker players also took a test of decision making in snooker. The snooker players scored significantly more field independent than the sports-science majors on the Group Embedded Figures Test. A Pearson correlation of 0.78 was obtained between scores on the Group Embedded Figures Test and the decision-making test. As there may be an association between scores on field dependence and decision making in snooker, further research should examine sports like lawn bowls and pool where decisions are made in a static environment. PMID:8170763

McMorris, T; Francis, M; MacDonald, A; Priday, K

1993-12-01

220

An Examination of the Correlates of Fearless Dominance and Self-Centered Impulsivity among High-Frequency Gamblers.  

Science.gov (United States)

The Psychopathic Personality Inventory (PPI) is a commonly used assessment of psychopathy. Questions have been raised, however, regarding the validity of its Fearless Dominance (FD) factor. In the current study, the correlations manifested by FD and Self-centered Impulsivity (ScI) in relation to external criteria were examined in a sample of gamblers. Two key hypotheses were also tested: (a) does FD perform differently when paired with high scores on ScI, and (b) does FD serve as an index of narcissism. As expected, FD and ScI manifested a divergent pattern of correlations such that only ScI was associated with psychopathology or impairment. FD's relations with the external criteria were not generally moderated by scores on ScI. FD was significantly correlated with narcissism, but the two differed such that only narcissism was associated with any degree of maladaptivity. It remains unclear whether FD should be considered a core component of psychopathy. PMID:24344842

Maples, Jessica L; Miller, Joshua D; Fortune, Erica; MacKillop, James; Campbell, W Keith; Lynam, Donald R; Lance, Chuck E; Goodie, Adam S

2014-06-01

 
 
 
 
221

Correlation of signal intensity ratio on orbital MRI-TIRM and clinical activity score as a possible predictor of therapy response in Graves' orbitopathy - a pilot study at 1.5 T  

International Nuclear Information System (INIS)

This study seeks to describe the predictive value of the signal intensity ratio (SIR) in magnetic resonance imaging-turbo inversion recovery magnitude (MRI-TIRM) in patients with Graves' orbitopathy (GO) with regard to predictability of therapy response. Included in this prospective pilot study were 36 consecutive patients with GO and 25 control subjects. Patients were clinically assessed according to the European Group on Graves' Orbitopathy recommendations with active GO defined by a clinical activity score (CAS) ? 3. On magnetic resonance (MR) imaging, muscle inflammation was measured with a region of interest set within the brightest extra-ocular muscle both on coronal turbo inversion recovery magnitude (TIRM) and on fat suppressed gadolinium-enhanced T1-weighted sequences. To calculate the SIR, the measured signal intensity was set in proportion to that of the ipsilateral temporalis muscle. Signal intensity ratio in coronal T2-weighted TIRM sequences in either group ranged from 1.22 to 4.92 (mean 2.04) in patients with GO and from 1.18 to 2.4 (mean 1.63) in controls without GO. The observed differences were significant on the TIRM sequences (right eye p = 0.023; left eye p = 0.022), whereas, no significant differences could be detected on the T1-weighted sequences (right eye p = 0.396; left eye p = 0.498). A cut off value of SIR > 2.5 for a CAS ? 4 to discriminate active from inactive patients was statistically calculated. T2 relaxation time is a reliable tool in detecting active GO. The difference in T2-SIR versus T1-SIR is helpful to distinguish inflammatory oedema of the extra ocular muscles from intra-orbital congestion due to reduced venous outflow. (orig.)

2010-02-01

222

Student-Centered Reliability, Concurrent Validity and Instructional Sensitivity in Scoring of Students' Concept Maps in a University Science Laboratory  

Science.gov (United States)

Student-centered approach of scoring the concept maps consisted of three elements namely symbol system, individual portfolio and scoring scheme. We scored student-constructed concept maps based on 5 concept map criteria: validity of concepts, adequacy of propositions, significance of cross-links, relevancy of examples, and interconnectedness. With…

Kaya, Osman Nafiz; Kilic, Ziya

2004-01-01

223

DEGAM criteria catalogue for training practices in Primary Care - a proposal for the assessment of the structural quality of training practices  

Science.gov (United States)

Background: Whilst the structure of primary care vocational training in Germany is being increasingly formalized there remains an abundance of disparate locally defined criteria for the training practices. Advanced medical training in the ambulatory setting has also been identified as an area of need by other specialties. Goal: In contrast to the current practice of a unregulated authorization by regional medical associations this catalogue provide transparent, clearly defined criteria for the assignment of training practice status. Methods: The first draft of the criteria catalogue integrates feedback from 30 academic general practitioners. The feasibility of the catalogue was tested by a further 30 surgeries. Analysis included an assessment of the sociodemographic characteristics of the trainers and their practices as well as satisfaction of the participants with the approved authorization period. Results: The criteria catalogue comprises 19 items within the domains of trainer qualification, practice infrastructure and patient specific factors as well as mandatory criteria. The points scored through this system confer a variable period of authorization. Of the 30 participants 17 were satisfied with the period of authorization they received, 10 were dissatisfied, and one was indifferent. Satisfaction showed no correlation with sex, experience as a trainer, or with the score achieved through the criteria catalogue. It correlated little with the length of time practicing as a doctor. Conclusion: The criteria catalogue reflects both the breadth of general practice as well as the skills of the trainers. Satisfaction of participants in the test group was good, and infers a basis for applying the catalogue through regional medical associations to assign teaching practice status. It may also be used as a blue-print for other medical specialties.

Egidi, Gunther; Bernau, Ruben; Borger, Matthias; Muhlenfeld, Hans-Michael; Schmiemann, Guido

2014-01-01

224

Performance criteria for radiobioassay  

Energy Technology Data Exchange (ETDEWEB)

The Bioassay Performance Criteria standard provides requirements for the accuracy, precision, and detection limits for measurements of selected radionuclides in the bodies of, or in biological samples from, persons occupationally exposed to the intake of radioactive materials. It also provides standard quality control procedures for the internal quality assurance programs of radiobioassay laboratories, and criteria to be used as a basis by testing laboratories to evaluate the conformance of radiobioassay service laboratories to both the quantitative performance criteria for accuracy, precision and detection limits, and standard quality control procedures.

Heid, K.R.; MacLellan, J.A.; Traub, R.J.

1985-12-01

225

Development of a software tool and criteria evaluation for efficient design of small interfering RNA.  

Science.gov (United States)

RNA interference can be used as a tool for gene silencing mediated by small interfering RNAs (siRNA). The critical step in effective and specific RNAi processing is the selection of suitable constructs. Major design criteria, i.e., Reynolds's design rules, thermodynamic stability, internal repeats, immunostimulatory motifs were emphasized and implemented in the siRNA design tool. The tool provides thermodynamic stability score, GC content and a total score based on other design criteria in the output. The viability of the tool was established with different datasets. In general, the siRNA constructs produced by the tool had better thermodynamic score and positional properties. Comparable thermodynamic scores and better total scores were observed with the existing tools. Moreover, the results generated had comparable off-target silencing effect. Criteria evaluations with additional criteria were achieved in WEKA. PMID:21145307

Chaudhary, Aparna; Srivastava, Sonam; Garg, Sanjeev

2011-01-01

226

Meteor Stream Membership Criteria  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Criteria for the membership of individual meteors in meteor streams are discussed from the point of view of their mathematical and also physical properties. Discussion is also devoted to the motivation. It is shown that standardly used criteria (mainly D-criterion of Southworth and Hawkins, 1963) have unusual mathematical properties in the sense of a term ``distance'', between points in a phase space, and, physical motivation and realization for the purpose of obtaining thei...

Klacka, Jozef

2000-01-01

227

Selection criteria of residents for residency programs in Kuwait  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background In Kuwait, 21 residency training programs were offered in the year 2011; however, no data is available regarding the criteria of selecting residents for these programs. This study aims to provide information about the importance of these criteria. Methods A self-administered questionnaire was used to collect data from members (e.g. chairmen, directors, assistants …etc. of residency programs in Kuwait. A total of 108 members were invited to participate. They were asked to rate the importance level (scale from 1 to 5 of criteria that may affect the acceptance of an applicant to their residency programs. Average scores were calculated for each criterion. Results Of the 108 members invited to participate, only 12 (11.1% declined to participate. Interview performance was ranked as the most important criteria for selecting residents (average score: 4.63/5.00, followed by grade point average (average score: 3.78/5.00 and honors during medical school (average score: 3.67/5.00. On the other hand, receiving disciplinary action during medical school and failure in a required clerkship were considered as the most concerning among other criteria used to reject applicants (average scores: 3.83/5.00 and 3.54/5.00 respectively. Minor differences regarding the importance level of each criterion were noted across different programs. Conclusions This study provided general information about the criteria that are used to accept/reject applicants to residency programs in Kuwait. Future studies should be conducted to investigate each criterion individually, and to assess if these criteria are related to residents' success during their training.

Marwan Yousef

2013-01-01

228

Multiple regression analysis of factors that may influence middle school science scores  

Science.gov (United States)

The purpose of this quantitative multiple regression study was to determine whether a relationship existed between Maryland State Assessment (MSA) reading scores, MSA math scores, gender, ethnicity, age, and MSA science scores. Also examined was if MSA reading scores, MSA math scores, gender, ethnicity, and age can be used in combination or alone to predict a passing score on the MSA science test and which variable, if any, had the most influence on science MSA scores. Both math and reading MSA scores were positively correlated with science MSA scores. Ethnicity was correlated with science MSA scores, but may have been confounded by socio-economic status. Age and gender were not correlated with science MSA scores. When the variables were combined, results showed that math MSA scores followed by reading MSA scores had the most predictive influence upon science MSA scores. Ethnicity, gender, and age had the least predictive influence. The findings of this study may serve as a catalyst for improving student achievement in science through changes in instructional methodology and curriculum design thereby increasing the number of students pursuing science careers.

Glover, Judith

229

Disease Severity Indexes and Treatment Evaluation Criteria in Vitiligo  

Digital Repository Infrastructure Vision for European Research (DRIVER)

There is a current lack of consensus regarding methods of assessment of vitiligo. Recently, the Vitiligo Area Scoring Index (VASI) and the Vitiligo European Task Force (VETF) were proposed to offer more accurate measures of disease severity indexes and treatment evaluation criteria. It would make sense to combine the VASI with the VETF system. We proposed an original scale for treatment evaluation criteria in vitiligo based on VASI. We plan to add the digital image analysis system, health-rel...

Kawakami, Tamihiro; Hashimoto, Takashi

2011-01-01

230

The association of gender and body mass index with postoperative pain scores when undergoing ankle fracture surgery  

Science.gov (United States)

Background: Intraoperative administration of opiates for postoperative analgesia requires a dosing strategy without clear indicators of pain in an anesthetized patient. Preoperative patient characteristics such as body mass index (BMI), gender, age, and other patient characteristics may provide important information regarding opiate requirements. This study intends to determine if there is an association between gender or BMI and the immediate postoperative pain scores after undergoing an open reduction and internal fixation (ORIF) of an ankle fracture with general anesthesia and morphine only analgesia. Materials and Methods: Using a retrospective cohort design, the perioperative records were reviewed at a university healthcare hospital. One hundred and thirty-seven cases met all inclusion and no exclusion criteria. Postanesthesia care unit (PACU) records were reviewed for pain scores at first report and 30 min later as well as PACU opiate requirements. T-test, chi-square, and Mann-Whitney tests compared univariate data and multivariate analysis was performed by linear regression. Results: There were no statistically significant PACU pain score group differences based on gender or BMI. Post hoc analysis revealed that in the setting of similar pain scores, obese patients received a similar weight based intraoperative morphine dose when using adjusted body weight (ABW) compared to nonobese subjects. A further finding revealed a negative correlation between age and pain score (P = 0.001). Conclusion: This study did not find an association between obesity or gender and postoperative pain when receiving morphine only preemptive analgesia. This study does support the use of ABW as a means to calculate morphine dosing for obese patients and that age is associated with lower immediate pain scores.

Grodofsky, Samuel Robert; Sinha, Ashish C

2014-01-01

231

Sensibilidad y especificidad de la escala de Alvarado en apendicitis aguda en el Hospital Regional de Alta Especialidad de Veracruz / Sensitivity and specificity of the Alvarado score in acute appendicitis, and its anatomopatological correlation at the High Specialty Regional Hospital of Veracruz  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish Objetivo: Determinar la sensibilidad y especificidad de la escala de Alvarado en el diagnóstico de apendicitis aguda en el Hospital Regional de Alta Especialidad de Veracruz. Sede: Hospital de alta especialidad de Veracruz. Diseño: Estudio transversal, ambispectivo, descriptivo, observacional. Análi [...] sis estadístico: Regresión logística binaria, chi cuadrada (?²), razón de momios y curvas ROC. Resultados: Se incluyeron 384 (293 retrospectivos y 91 prospectivos) pacientes con diagnóstico de probable apendicitis y que fueron operados. Mediante un análisis estadístico se encontró que con la escala de Alvarado en el punto de corte >5 se obtiene una mayor precisión diagnóstica, con sensibilidad de 0.96%, especificidad de 0.72, valor predictivo positivo de 0.93% y valor predictivo negativo de 0.82. El criterio más encontrado fue el dolor en fosa iliaca derecha, positivo en el 100% de pacientes intervenidos con apendicitis; sin embargo, el más específico fue el rebote con 94.3% de los pacientes. Conclusión: Los criterios de Alvarado son una herramienta útil para el diagnóstico de apendicitis aguda, son aplicables en todos los pacientes con dolor abdominal agudo sugestivo de apendicitis como prueba al ingreso y para descartar patología apendicular en 5 puntos o menos. Abstract in english Objective: To determine the sensitivity and specificity of the Alvarado Score for the diagnosis of acute appendicitis at a high specialty regional hospital. Setting: High specialty regional hospital in the city of Veracruz, Veracruz, Mexico. Design: Cross-sectional, descriptive, ambispective observa [...] tional study. Statistical analysis: Binary logistic regression, chi square (?2), odds ratio and ROC curves. Results: The study included 384 (293 retrospective and 91 prospective) patients with a diagnosis of probable appendicitis and who were operated. Statistical analysis revealed that a better diagnostic accuracy is achieved with the Alvarado Score at a cut off >5, with a sensitivity of 0.96%, specificity of 0.72, positive predictive value of 0.93% and negative predictive value of 0.82. The most frequently found criterion was pain in the right iliac fossa positive in 100% of patients with appendicitis subjected to surgery; however, the most specific criterion was the rebound with 94.3% of patients. Conclusion: Criteria of the Alvarado Score are a useful tool for the diagnosis of acute appendicitis, it is applicable to all patients with acute abdominal pain suggestive of appendicitis as an admittance test, and to discard appendicular pathology in 5 points or less.

Hernández Miguelena, Luis; Domínguez Solano, David Román.

232

Detecting an event of progression using glaucoma probability score and the stereometric parameters of Heidelberg Retina Tomograph 3.  

Science.gov (United States)

Purpose: To evaluate the correlation of the change in glaucoma probability score (GPS) and the stereometric optic nerve head (ONH) parameters of the Heidelberg Retina Tomograph (HRT)3 to an event of glaucomatous progression observed with stereoscopic ONH photography.Methods: The subjects for this retrospective follow-up study were monitored with the HRT and stereoscopic ONH photographs. Stable, high-quality imaging and at least 18 months of follow-up was required. The topography examinations were acquired using HRT II and calculated with HRT3 software. The event of progression was determined by masked evaluation of stereoscopic ONH photographs.Results: A total of 476 eyes of 342 subjects met the inclusion criteria. All the examinations with HRT II were backwards compatible with either the GPS or the stereometric parameters of HRT3. The highest statistical significance for the correlation with progression was observed in the change in cup volume and cup:disc area ratio (pglaucoma. PMID:24338582

Saarela, Ville; Falck, Aura; Tuulonen, Anja

2014-06-23

233

International Validation of the Low Anterior Resection Syndrome Score  

DEFF Research Database (Denmark)

OBJECTIVE:: The aims of this study were to investigate the convergent and discriminative validity and reliability of the low anterior resection syndrome (LARS) score in an international setting. BACKGROUND:: The LARS score is a simple self-administered questionnaire measuring bowel dysfunction after rectal cancer surgery. The score is intended to be commonly used in international research and clinical practice in the future. Therefore, a thorough validation in an international setting is of utmost importance. METHODS:: The LARS score was translated using methods in keeping with current international recommendations. A total of 801 patients operated for rectal cancer in Sweden, Spain, Germany, and Denmark completed the LARS score questionnaire, including an anchor question assessing the impact of bowel function on quality of life. A subgroup of 218 patients completed the LARS score twice. Data were analyzed per country. RESULTS:: The LARS score has demonstrated a high convergent validity in terms of a high correlation between LARS score and quality of life (P <0.001). Sensitivity ranged from 67.7% to 88.3% and specificity from 58.1% to 86.3%. The LARS score was able to discriminate between groups of patients differing with regard to radiotherapy, surgery, and age (P <0.05). The score also demonstrated high reliability at test-retest with narrow limits of agreement and no statistically significant difference between scores at the first and second test. CONCLUSIONS:: The Swedish, Spanish, German, and Danish versions of the LARS score have proven to be valid and reliable tools for measuring LARS in European rectal cancer patients.

Juul, Therese; Ahlberg, Madelene

2013-01-01

234

Association of Apgar scores with death and neurologic disability  

Directory of Open Access Journals (Sweden)

Full Text Available Vera EhrensteinDepartment of Clinical Epidemiology, Aarhus University Hospital, DenmarkAbstract: Apgar score was devised with the aim to standardize the assessment of newborns. It has been used worldwide to evaluate infants’ condition immediately after birth, to determine their need for resuscitation, and to evaluate the effectiveness of resuscitation. Apgar score was never intended for prediction of outcome beyond the immediate postnatal period; however, since low scores correlate with prenatal and perinatal adversities, multiple studies have examined the relation between the value of Apgar score and duration of low (<7 Apgar score and subsequent death or neurologic disability. This article reviews such studies. The author concludes that the overall evidence shows consistent association of low Apgar scores with increased risks of neonatal and infant death and with neurologic disability, including cerebral palsy, epilepsy, and cognitive impairment. Dose-response patterns have been shown for the value of Apgar score and duration of low score and the outcomes of mortality and neurologic disability. The association of Apgar score <7 at five minutes with increased risks of neurologic disability seems to persist many years postnatally. Some corresponding relative risk estimates are large (eg, four to seven for epilepsy or more than 20 for cerebral palsy, while others are modest (eg, 1.33 for impaired cognitive function. The absolute risks, however, are low (<5% in for most neurologic conditions, and majority of surviving babies with low Apgar scores grow up without disability. The low magnitude of absolute risks makes Apgar score a poor clinical predictor of long-term outcome. Nevertheless, the observed associations point to the importance of fetal and perinatal periods for neurodevelopment.Keywords: Apgar score, epidemiology, neonatal death, neurologic disorders

Vera Ehrenstein

2009-05-01

235

Comparison between needle biopsy and radical prostatectomy samples in assessing Gleason score and modified Gleason score in prostatic adenocarcinomas  

Directory of Open Access Journals (Sweden)

Full Text Available Histologic grading is an important predictor of prostatic disease stage and prognosis. We aimed to assess the degree of concordance between pathologic characteristics of the specimens obtained from biopsy and radical prostatectomy materials.Gleason scores and modified Gleason scores calculated for 25 cases of prostatic adenocarcinoma from both needle biopsy and radical prostatectomy specimens were analyzed.Mean Gleason scores for biopsy and radical specimens were 6.4 (SD:±0.7 and 6.64 (SD:±1.3; and corresponding modified Gleason scores were 7.32 (SD:±1.43 and 7.32 (SD:±0.98, respectively. The Gleason scores of biopsy and radical prostatectomy specimens were identical in 48% (12/25 of the cases, while 32% (8/25 of the biopsy specimens were over-and 20% (5/25 of them were undergraded. While assessing modified Gleason scores, the exact degree of concordance of biopsy specimens with radical prostatectomy materials was 56% (14/25 and of the 11 (44% cases not correlated exactly, 6 (24% were over- and 5 (20% were undergraded. When the exact, over- and underestimated scores of Gleason and modified Gleason grading systems were compared statistically, no difference between two groups was seen (p>0.05. Overgrading errors were found to be more than undergrading errors for both of the scoring systems. Using either the modified Gleason or traditional Gleason scoring

Banu DO?AN GÜN

2007-01-01

236

piano_prosthesis: indicative score  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This score can be used as a creative starting point, as a open-form score that defines all materials you use, or ignored. The overall aim is to establish clearly differentiated musical materials, characterised by pitch, loudness, density, rhythmic activity, sustained-ness and the degree of internal variation (within a timeframe of 10-20 sec.) Having decided upon materials, either in advance or during the performance, the improvisation should focus on recalling and varying these types. Sile...

Young, Michael W.

2009-01-01

237

Influence of low-stress handling on reactivity score and pregnancy rate during fixed-time artificial insemination in Nellore cows  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The objective of this work was to evaluate the influence of low-stress handling (LSH) on reactivity score and pregnancy rate during fixed-time artificial insemination (FTAI) for extensively raised Nellore cows. Multiparous cows (n = 126) were randomly allocated into two groups: G1 (n = 66) and G2, t [...] he control group (n = 60). Group G1 was subjected to LSH, in which the animals were handled in a calm and quiet manner, without loud noises or physical aggression, using the point of balance, respecting the flight zone and using flags to supplement handling. Group G2 was handled following the typical procedure, with yelling, kicking and the use of electric prods and sticks. On D0, D8 and D10, FTAI was performed in both groups. Reactivity was scored on D0, D8 and D10 at the squeeze chute, based on the tension score, breathing score, and bellowing score. Using the three criteria above, the reactivity scores were defined as follows: R1 (calm); R2 (slightly reactive); R3 (moderately reactive); R4 (reactive); and R5 (highly reactive). Thirty-five days after artificial insemination, pregnancy was determined using ultrasonography. There was no significant correlation between reactivity score and pregnancy rate in each group or between the pregnancy rates in both groups. However, there was a statistically significant difference between the G1 and G2 groups with regard to reactivity score (1.62±0.05 vs. 2.12±0.07). Low-stress handling influenced reactivity but did not affect pregnancy rate in extensively raised Nellore cows subjected to FTAI.

Tirloni, Rayf Roberto; Rocha, Fábio Alcântara; Lourenço, Fábio José; Martins, Lílian Rigatto.

238

Clinical performance of two visual scoring systems in detecting and assessing activity status of occlusal caries in primary teeth  

DEFF Research Database (Denmark)

This study aimed to compare the clinical performance of two sets of visual scoring criteria for detecting caries severity and assessing caries activity status in occlusal surfaces. Two visual scoring systems--the Nyvad criteria (NY) and the ICDAS-II including an adjunct system for lesion activity assessment (ICDAS-LAA)--were compared using 763 primary molars of 139 children aged 3-12 years. The examinations were performed by 2 calibrated examiners. A subsample (n = 50) was collected after extraction and histology with 0.1% red methyl dye was performed to validate lesion depth and activity. The reproducibility of the indices was calculated (kappa test) and ROC analysis was performed to assess their validity and related parameters were compared using McNemar's test. The association between the indices and with the histological examination was evaluated using Spearman's correlation coefficient (r(s)). Visual criteria showed excellent reproducibility both regarding severity (NY: 0.94; ICDAS-II: 0.91) and activity(NY: 0.90; LAA: 0.91). The NY and LAA showed good association in caries activity assessment (r(s) = 0.88; 95% CI = 0.86-0.89; p 0.05). Concerning the severity, both indices presented similar validity parameters. At D2 threshold, the sensitivity was higher for NY (NY = 0.87; ICDAS = 0.61, p <0.05). Regarding activity status, NY showed higher specificities and accuracies. In conclusion, NY and ICDAS-II criteria are comparable and present good reproducibility and validity to detect caries lesions and estimate their severities, but the LAA seems to overestimate the caries activity assessment of cavitated lesions compared to NY.

Braga, M M; Ekstrand, K R

2010-01-01

239

The Effect of Logical Choice Weight and Corrected Scoring Methods on Multiple Choice Agricultural Science Test Scores  

Directory of Open Access Journals (Sweden)

Full Text Available The study focused on the effect of logical choice weight and corrected scoring methods on multiple choice Agricultural science test scores the study also investigated the interaction effect of logical choice weight and corrected scoring methods in schools ,and types of school in multiple choice agricultural science test. The researcher used a combination of survey type and one short experimental design. The sample for the study consisted of 600 students selected by stratified random sampling techniques in south western Nigeria. Overall performance of students in percentage, and correlation was analyzed. The hypotheses were generated and tested at 0.05 level of significance. The study revealed that there was a significant difference in the academic performance of students in logical choice weight and corrected scoring methods in multiple choice agricultural science test scores. The result also shown that there was no interaction effect on the two scoring methods in the type of schools, the location of schools in multiple choices agricultural science test. The study revealed that logical choice weight scoring method was the best method that favoured the scoring of the students’ scripts in multiple choices agricultural science test. On the basis of these findings, logical choice weight should be introduced to the teachers to use in the classroom as a new method of scoring multiple choice agricultural science the logical choice weight method is recommended in the ministry of education, in Examination Division, and to junior secondary schools for scoring JSS (3 three multiple choice test. Examination bodies such as West Africa Examination Council (WAEC, National Examination Council (NECO, Joint Admission and Matriculation Board (JAMB should adopt the use of logical choice weight method in scoring multiple choice tests. The method could be used in tertiary institutions for post ‘JAMB’ Unify Matriculation Examination (UME test. It is also recommended for all states of the federation as well the West African countries public service could also adopt the use of logical choice weight scoring method.

B. K. Ajayi

2012-12-01

240

Effects of credit scores on consumer payment choice  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This paper investigates the effects of credit scores on consumer payment behavior, especially on debit and credit card use. Anecdotally, a negative relationship between debit card use and credit score has been reported; however, it is not clear whether that relationship is related to other factors, such as education or income, or whether it is a mere correlation. We use a new consumer survey dataset to examine whether this negative relationship holds after controlling for various consumer cha...

2012-01-01

 
 
 
 
241

The Inter-rater Reliability in Scoring Composition  

Directory of Open Access Journals (Sweden)

Full Text Available This paper makes a study of the rater reliability in scoring composition in the test of English as a foreign language (EFL and focuses on the inter-rater reliability as well as several interactions between raters and the other facets involved (that is examinees, rating criteria and rating methods. Results showed that raters were fairly consistent in their overall ratings. This finding has the great implications for controlling and assuring the quality of the rater-mediated assessment system.

Ping Wang

2009-08-01

242

Meteor Stream Membership Criteria  

CERN Document Server

Criteria for the membership of individual meteors in meteor streams are discussed from the point of view of their mathematical and also physical properties. Discussion is also devoted to the motivation. It is shown that standardly used criteria (mainly D-criterion of Southworth and Hawkins, 1963) have unusual mathematical properties in the sense of a term ``distance'', between points in a phase space, and, physical motivation and realization for the purpose of obtaining their final form is not natural and correct, and, moreover, they lead also to at least surprising astrophysical results. General properties of possible criteria are discussed. A new criterion for the membership in meteor streams is suggested. It is based on probability theory. Finally, a problem of meteor orbit determination for known parent body is discussed.

Klacka, J

2000-01-01

243

Dual Criteria Decisions  

DEFF Research Database (Denmark)

The most popular models of decision making use a single criterion to evaluate projects or lotteries. However, decision makers may actually consider multiple criteria when evaluating projects. We consider a dual criteria model from psychology. This model integrates the familiar tradeoffs between risk and utility that economists traditionally assume, allowance for rank-dependent decision weights, and consideration of income thresholds. We examine the issues involved in full maximum likelihood estimation of the model using observed choice data. We propose a general method for integrating the multiple criteria, using the logic of mixture models, which we believe is attractive from a decision-theoretic and statistical perspective. The model is applied to observed choices from a major natural experiment involving intrinsically dynamic choices over highly skewed outcomes. The evidence points to the clear role that income thresholds play in such decision making, but does not rule out a role for tradeoffs between riskand utility or probability weighting.

Andersen, Steffen; Harrison, Glenn W.

2014-01-01

244

Summarized water quality criteria  

International Nuclear Information System (INIS)

The available world literature from 27 sources on existing water quality criteria are summarized for the 15 main uses of water. The minimum, median and maximum specified values for 96 different determinands are included. Under each water use the criteria are grouped according to the functional significance of the determinands e.g. aesthetic/physical effects, high toxic potential, low toxic potential etc. A synopsis is included summarizing salient facts for each determinand such as the conditions under which it is toxic and its relationship to other determinands. The significance of the criteria is briefly discussed and the importance of considering functional interactions between determinands emphasized in evaluating the potential for toxic or beneficial effects. From the source literature it appears that the toxic potential, in addition to being determined by concentration, is also affected by the origin of the substance concerned, i.e. whether from natural sources or from anthropogenic pollution

1980-01-01

245

Neurointerventional Treatment in Acute Stroke. Whom to Treat? (Endovascular Treatment for Acute Stroke: Utility of THRIVE Score and HIAT Score for Patient Selection)  

Energy Technology Data Exchange (ETDEWEB)

Purpose: Intra-arterial therapy (IAT) is used increasingly as a treatment option for acute stroke caused by central large vessel occlusions. Despite high rates of recanalization, the clinical outcome is highly variable. The authors evaluated the Houston IAT (HIAT) and the totaled health risks in vascular events (THRIVE) score, two predicting scores designed to identify patients likely to benefit from IAT. Methods: Fifty-two patients treated at the Stavanger University Hospital with IAT from May 2009 to June 2012 were included in this study. We combined the scores in an additional analysis. We also performed an additional analysis according to high age and evaluated the scores in respect of technical efficacy. Results: Fifty-two patients were evaluated by the THRIVE score and 51 by the HIAT score. We found a strong correlation between the level of predicted risk and the actual clinical outcome (THRIVE p = 0.002, HIAT p = 0.003). The correlations were limited to patients successfully recanalized and to patients <80 years. By combining the scores additional 14.3 % of the patients could be identified as poor candidates for IAT. Both scores were insufficient to identify patients with a good clinical outcome. Conclusions: Both scores showed a strong correlation to poor clinical outcome in patients <80 years. The specificity of the scores could be enhanced by combining them. Both scores were insufficient to identify patients with a good clinical outcome and showed no association to clinical outcome in patients aged {>=}80 years.

Fjetland, Lars, E-mail: lars.fjetland@lyse.net; Roy, Sumit, E-mail: sumit.roy@sus.no; Kurz, Kathinka D., E-mail: kathinka.dehli.kurz@sus.no [Stavanger University Hospital, Department of Radiology (Norway); Solbakken, Tore, E-mail: tore.solbakken@sus.no [Stavanger University Hospital, Department of Neurology (Norway); Larsen, Jan Petter, E-mail: jan.petter.larsen@sus.no; Kurz, Martin W., E-mail: martin.kurz@sus.no [The Norwegian Center for Movement Disorders, Stavanger University Hospital (Norway)

2013-10-15

246

Psychometric Properties of Scores from the Web-based LibQUAL+ Study of Perceptions of Library Service Quality.  

Science.gov (United States)

Investigated the psychometric integrity of scores from the LibQUAL+ evaluation of perceived library service quality conducted by ARL (Association of Research Libraries). Examines score structure, score reliability, score correlation and concurrent validity coefficients, scale means, and scale standardized norms, and considers the potential of the…

Cook, Colleen; Thompson, Bruce

2001-01-01

247

Comparison of experts and non-experts in throwing darts based on optimization criteria.  

Science.gov (United States)

Acquiring skillful movements of experts is a difficult task in many fields. Since non-experts often fail to find out how to improve their skill, it is desirable to find quantitative indices of skillful movements that clarify the difference between experts and non-experts. If we find quantitative indices, we can develop an adaptive training system using the indices. In this study, we quantitatively compare dart-throwing movements between experts and non-experts based on their scores, motions, and EMG signals. First, we show that the variance of upper-limb motion trajectories of the experts is significantly smaller than that of the non-experts. Then, we show that the displacement and the variance of the shoulder of the experts are also significantly smaller than those of the non-experts. The final result is the highlight of this study. We investigated their upper-limb motions from the viewpoint of trajectory optimization. In this study, we focus on two popular optimization criteria, i.e., sum of squared jerk over a trajectory and sum of squared joint-torque change over a trajectory. We present that the sum of squared joint torques of the subjects was negatively correlated with their scores (p < 0.05), whereas the other criteria were not. PMID:19963775

Obayashi, Chihiro; Tamei, Tomoya; Imai, Akira; Shibata, Tomohiro

2009-01-01

248

Graphite criteria peer review  

Energy Technology Data Exchange (ETDEWEB)

This report documents a review of the stress criteria proposed for the graphite components of the modular high temperature gas-cooled reactor (MHTGR) core. The review was conducted by a panel of six independent consultants, chosen for their expertise over a range of relevant disciplines.

NONE

1986-09-01

249

MERIT Award Criteria  

Science.gov (United States)

MERIT Award Criteria The MERIT Award (R37) program provides a means to recognize the most outstanding R01 applications from superior researchers. Program staff and/or members of the National Cancer Advisory Board will identify candidates for the MERIT

250

Ligand Identification Scoring Algorithm (LISA).  

Science.gov (United States)

A central problem in de novo drug design is determining the binding affinity of a ligand with a receptor. A new scoring algorithm is presented that estimates the binding affinity of a protein-ligand complex given a three-dimensional structure. The method, LISA (Ligand Identification Scoring Algorithm), uses an empirical scoring function to describe the binding free energy. Interaction terms have been designed to account for van der Waals (VDW) contacts, hydrogen bonding, desolvation effects, and metal chelation to model the dissociation equilibrium constants using a linear model. Atom types have been introduced to differentiate the parameters for VDW, H-bonding interactions, and metal chelation between different atom pairs. A training set of 492 protein-ligand complexes was selected for the fitting process. Different test sets have been examined to evaluate its ability to predict experimentally measured binding affinities. By comparing with other well-known scoring functions, the results show that LISA has advantages over many existing scoring functions in simulating protein-ligand binding affinity, especially metalloprotein-ligand binding affinity. Artificial Neural Network (ANN) was also used in order to demonstrate that the energy terms in LISA are well designed and do not require extra cross terms. PMID:21561101

Zheng, Zheng; Merz, Kenneth M

2011-06-27

251

Docking and scoring of metallo-beta-lactamases inhibitors  

DEFF Research Database (Denmark)

The performance of the AutoDock, GOLD and FlexX docking programs was evaluated for docking of dicarboxylic acid inhibitors into metallo-beta-lactamases (MBLs). GOLD provided the best overall performance, with RMSDs between experimental and docked structures of 1.8-2.6 A and a good correlation between the experimentally determined MBL-inhibitor affinities and the GOLD scores. GOLD was selected for a test including a broad spectrum of inhibitors for which experimental MBL-inhibitor binding affinities are available. This study revealed that (1) for most compound classes (dicarboxylic acids, tetrazoles, sulfonylhydrazones, and peptide-like compounds) there is a good correlation between the experimentally determined MBL-inhibitor affinities and the GOLD scores, (2) the correlation only holds within a given class, that is, scores of compounds from different classes cannot be directly compared, (3) for some compound classes (e.g. small sulphur compounds) there is no direct correlation between the experimentally determined MBL-inhibitor affinities and the GOLD scores. Using partial least squares methods, a model with R2 = 0.82 and Q2 = 0.78 for the training set was obtained based on the GOLD score and descriptors associated with binding of the IMP-1 inhibitors to the enzyme. The external Q2 for the test set is 0.73. This final model for prediction of IMP-1 MBL-inhibitor affinity handled all known classes of MBL-inhibitors, except small sulphur compounds.

Olsen, Lars; Pettersson, Ingrid

2004-01-01

252

A Bootstrap Procedure of Propensity Score Estimation  

Science.gov (United States)

Propensity score estimation plays a fundamental role in propensity score matching for reducing group selection bias in observational data. To increase the accuracy of propensity score estimation, the author developed a bootstrap propensity score. The commonly used propensity score matching methods: nearest neighbor matching, caliper matching, and…

Bai, Haiyan

2013-01-01

253

Estimating Decision Indices Based on Composite Scores  

Science.gov (United States)

The purpose of this study was to develop an IRT model that would enable the estimation of decision indices based on composite scores. The composite scores, defined as a combination of unidimensional test scores, were either a total raw score or an average scale score. Additionally, estimation methods for the normal and compound multinomial models…

Knupp, Tawnya Lee

2009-01-01

254

RIA Criteria in Japan  

International Nuclear Information System (INIS)

To assess the Reactivity Insertion Events, Japanese Nuclear Safety Commission (NSC) formulated 'Evaluation Guide for Reactivity Insertion Events of Light Water Nuclear Power Reactor Facilities' in 1984 based on the data from NSRR experiments. For the reactivity insertion accident (RIA), the following criteria are applied. (1) Peak fuel enthalpy must not exceed the prescribed limit of 230 cal/g. (2) Maximum pressure to the pressure boundary must be lower than 1.2 times of the design pressure. (3) Undue radiation exposure to the neighboring public must be avoided. Besides, the following additional criteria is applied. (4) The reactor pressure vessel must not be damaged due to shock wave and water hammer generated by waterlogged fuel rupture. To calculate the number of fuel failures related to criteria (3), the fuel failure thresholds due to high temperature rupture and PCMI failure are defined. Related to the criteria (4), mechanical energy generated by waterlogged fuel rupture is evaluated. The results of recent reactivity insertion accident (RIA) experiments with high burnup fuel performed in France (CABRI) and in Japan (NSRR) indicated that some fuel failed at the lower deposited energy in the fuel than was previously assumed. Taking it seriously, Japanese NSC had assessed the following high burnup issues based on the new data from CABRI and NSRR tests. (a) Decrease of fuel melting point due to burnup increase, addition of gadolinium, plutonium etc. (b) PCMI failure threshold (c) Mechanical energy generated by fuel particle dispersal at low energy PCMI failures (d) Coolability for debris due to fuel dispersal (e) Fission gas releases. The Japanese NSC revised the licensing criteria for RIA in 1998 based on the assessment of high burnup issues. The enthalpy limit to avoid fuel melting and PCMI failure threshold were revised for high burnup fuels. Also, the evaluation of mechanical energies generated by PCMI failure was added in the safety assessment of RIA to confirm the integrity of reactor pressure vessel. (author)

2003-04-30

255

Locomotion problems of broiler chickens and its relationship with the gait score  

Directory of Open Access Journals (Sweden)

Full Text Available The objective of this study was to evaluate the correlation between the ability to walk (gait score, incidence of femoral degeneration, tibial dyschondroplasia, valgus and varus deformity and leg symmetry of broiler chickens. Male chickens of the Cobb strain from a commercial poultry farm were utilized in this experiment. Fifty 35 and 42-day-old birds were evaluated according to the gait score and valgus or varus incidence. To assess the bilateral symmetry and the lesion score for femoral degeneration and tibial dyschondroplasia, broilers were weighed and euthanized for the removal of the femur and tibia of both legs. The lesion scores for femoral degeneration and tibial dyschondroplasia, varus or valgus deformity, bone symmetry and gait scores of the chickens were then correlated. It was found that weight, age and the incidence of femoral degeneration and tibial dyschondroplasia are not always correlated with the gait score and that only valgus deformity is more correlated.

Barbara Cristina da Silva Fernandes

2012-08-01

256

Admission criteria to Saudi medical schools. Which is the best predictor for successful achievement?  

Directory of Open Access Journals (Sweden)

Full Text Available Objectives: To assess the relationship between current pre-admission criteria and medical student’s grade point average (GPA at the end of year 6 in 3 medical schools in the Kingdom of Saudi Arabia. Methods: We conducted this observational analytical study at 3 government medical schools in the Kingdom of Saudi Arabia between January 2011 and February 2012. High school grades, achievement test (Tahsili test scores, aptitude test (Qudraat tests scores, Mathematics, and English grades in the high school were used to predict medical student’s GPA at the end of year 6. The criterion variable was student’s cumulative GPA at the end of year 6. Correlation between pre-admission variables and GPA was calculated using Pearson’s correlation, and multiple regression analyses. The Institutional review board and ethical committee at Taif Medical College approved the study. Results: We included 727 students in this study from the chosen medical schools. A significant positive correlation was observed among all pre-admission variables and GPA. Inclusion of all 5 sets in multiple regression analyses revealed that the achievement test, English grade in the high school, high school grade and aptitude test (Qudraat tests were statistically predictive of GPA. A 20.8% variance in the GPA can be accounted for by the pre-admission criteria. Conclusion: Multiple pre-admission factors predict medical students GPA. Achievement test is the most important predictor. High school grades in English emerged as an independent predictor. Medical schools should give more attention to these predictors during admissions. 

Syed M. Aly

2012-11-01

257

Finding nearly optimal GDT scores.  

Science.gov (United States)

Global Distance Test (GDT) is one of the commonly accepted measures to assess the quality of predicted protein structures. Given a set of distance thresholds, GDT maximizes the percentage of superimposed (or matched) residue pairs under each threshold, and reports the average of these percentages as the final score. The computation of GDT score was conjectured to be NP-hard. All available methods are heuristic and do not guarantee the optimality of scores. These heuristic strategies usually result in underestimated GDT scores. Contrary to the conjecture, the problem can be solved exactly in polynomial time, albeit the method would be too slow for practical usage. In this paper we propose an efficient tool called OptGDT to obtain GDT scores with theoretically guaranteed accuracies. Denote ? as the number of matched residue pairs found by OptGDT for a given threshold d. Let ?' be the optimal number of matched residues pairs for threshold d/(1?+??), where ? is a parameter in our computation. OptGDT guarantees that ?????'. We applied our tool to CASP8 (The eighth Critical Assessment of Structure Prediction Techniques) data. For 87.3% of the predicted models, better GDT scores are obtained when OptGDT is used. In some cases, the number of matched residue pairs were improved by at least 10%. The tool runs in time O(n³) log n/??) for a given threshold d and parameter ?. In the case of globular proteins, the tool can be improved to a randomized algorithm of O(n log² n) runtime with probability at least 1?-?O(1/n). Released under the GPL license and downloadable from http://bioinformatics.uwaterloo.ca/?scli/OptGDT/ . PMID:21554017

Li, Shuai Cheng; Bu, Dongbo; Xu, Jinbo; Li, Ming

2011-05-01

258

[From Gleason score to Ann Arbor staging- a selective choice of important scores and staging systems in oncology].  

Science.gov (United States)

Hundreds scores and dozens staging systems exist in Oncology. They provide for example information on the spread and prognosis of a disease or are included in treatment decisions. Because of the existing diversity a description of all oncological codes would exceed the scope of this paper, the following articles focuses in the first part on some exemplary and lesser-known scores and in the second part on main staging systems in Oncology. Internet sites such as Wikipedia or Onkopedia provide answers to many other questions regarding ongologic scores and stages. As an example of a tumor graduation the Gleason score in prostate cancer is described. It provides not only information about the prognosis of the disease, but influences the primary treatment. In metastasic disease, the general condition of the patient is decisive on the question of whether a (further) systemic therapy should be applied. The general condition is classified with the Karnofsky index and in Oncology more frequently with the ECOG- or WHO-performance status. In solid tumors the response to treatment is assessed with RECIST criteria. The spread of solid malignancies is documented according to the TNM classification. This classification is regularly updated according to latest prognostic and therapeutic results. In contrast the Ann Arbor criterias - the staging system of lymphomas - have little changed since their initial description. PMID:24091341

Greuter, Stefan

2013-10-01

259

Validation of the Rheumatoid and Arthritis Outcome Score (RAOS for the lower extremity  

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Full Text Available Abstract Background Patients with inflammatory joint diseases tend due to new treatments to be more physically active; something not taken into account by currently used outcome measures. The Rheumatoid and Arthritis Outcome Score (RAOS is an adaptation of the Knee injury and Osteoarthritis Outcome Score (KOOS and evaluates functional limitations of importance to physically active people with inflammatory joint diseases and problems from the lower extremities. The aim of the study was to test the RAOS for validity, reliability and responsiveness. Methods 119 in-patients with inflammatory joint disease (51% RA admitted to multidisciplinary care, mean age 56 (±13, 73% women, mean disease duration 18 (±14 yr were consecutively enrolled. They all received the RAOS, the SF-36, the HAQ and four subscales of the AIMS2 twice during their stay for test of validity and responsiveness. Test-retest reliability of the RAOS questionnaire was calculated on 52 patients using the first or second administration and an additional mailed questionnaire. Results The RAOS met set criteria of reliability and validity. The random intraclass correlation coefficient (ICC 2,1 for the five subscales ranged from 0.76 to 0.92, indicating that individual comparisons were possible except for the subscale Sport and Recreation Function. Inter-item correlation measured by Cronbach's alpha ranged from 0.78 to 0.95. When measuring construct validity the highest correlations occurred between subscales intended to measure similar constructs. Change over time (24 (± 7 days due to multidisciplinary care was significant for all subscales (p Conclusion It is possible to adapt already existing outcome measures to assess other groups with musculoskeletal difficulties in the lower extremity. The RAOS is a reliable, valid and responsive outcome instrument for assessment of multidisciplinary care. To fully validate the RAOS further studies are needed in other populations.

Petersson Ingemar F

2003-10-01

260

Comparing the Simplified and International Autoimmune Hepatitis Group Criteria in Primary Sclerosing Cholangitis  

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Background and aims: Although highly sensitive and specific, the revised International Autoimmune Hepatitis Group (IAIHG) diagnostic criteria for autoimmune hepatitis (AIH) are cumbersome to use in clinical practice and rely upon a number of autoantibodies that are costly and are not widely available. The simplified scoring system for AIH attempts to rectify the complexity of the IAIHG criteria. To date, there have been few studies assessing the specificity of the simplified score for AIH whe...

Chandok, Natasha; Silveira, Marina G.; Lindor, Keith D.

2010-01-01

 
 
 
 
261

Human Systems Design Criteria  

DEFF Research Database (Denmark)

This paper deals with the problem of designing more humanised computer systems. This problem can be formally described as the need for defining human design criteria, which â?? if used in the design process - will secure that the systems designed get the relevant qualities. That is not only the necessary functional qualities but also the needed human qualities. The author's main argument is, that the design process should be a dialectical synthesis of the two points of view: Man as a System Component, and System as Man's Environment. Based on a man's presentation of the state of the art a set of design criteria is suggested and their relevance discussed. The point is to focus on the operator rather than on the computer. The crucial question is not to program the computer to work on its own conditions, but to â??programâ? the operator to function on human conditions.

Rasmussen, Jens

1982-01-01

262

Intelligent intefrace design criteria  

International Nuclear Information System (INIS)

Optimum adequation between control means and the capacities of the teams of operators is sought for to achieve computerization of control and monitoring interfaces. Observation of the diagnosis activity of populations of operators in incident situations on a simulator enables design criteria well-suited to the characteristics of the detection, interpretation of symptoms and incident location tasks to be defined. A software tool based on a qualitative approach enables the design process to be systematized

1989-10-10

263

Weighting Regressions by Propensity Scores  

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Regressions can be weighted by propensity scores in order to reduce bias. However, weighting is likely to increase random error in the estimates, and to bias the estimated standard errors downward, even when selection mechanisms are well understood. Moreover, in some cases, weighting will increase the bias in estimated causal parameters. If…

Freedman, David A.; Berk, Richard A.

2008-01-01

264

Tolerance Intervals for True Scores.  

Science.gov (United States)

Issues regarding tolerance and confidence intervals are discussed within the context of educational measurement, and conceptual distinctions are drawn between these two types of intervals. Points are raised about the advantages of tolerance intervals when the focus is on a particular observed score rather than a particular examinee. (Author/BW)

Jarjoura, David

1985-01-01

265

Evaluation of physiologic scoring systems as prognostic parameters of liver transplant in acute and chronic liver failure  

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Introduction: The current organ shortage and the mortality on waiting list for liver transplant (OLT) remain a particular challenge for transplant community. With the introduction of clinical scoring systems, objective criteria could optimize the patient selection for OLT.

2013-01-01

266

Translatability scoring in drug development: eight case studies  

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Full Text Available Abstract Translational medicine describes the transfer of basic in vitro and in vivo data into human applications. In the light of low rates of market approvals for new medical entities, better strategies to predict the risk of drug development should be used to increase output and reduce costs. Recently, a scoring system to assess the translatability of early drug projects has been proposed. Here eight drugs from different therapeutic areas have been subjected to a retrospective test-run in this system fictively located at the phase II-III transition. The scores gained here underline the importance of biomarker quality which is pivotal to decrease the risk of the project in all cases. This is particularly evident for gefitinib. The EGFR mutation status is a breakthrough biomarker to predict therapeutic success which made this compound clinically acceptable, and this is plausibly reflected by a considerable increase of the translatability score. For psychiatric and Alzheimer's drugs, and for a CETP-inhibitor, the lack of suitable biomarkers and animal models is reflected by a low translatability score, well correlating with the excessive translational risk in these areas. These case studies document the apparent utility of the scoring system, at least under retrospective conditions, as the scores correlate with the outcomes at the level of market approval. Prospective validation is still missing, but these case studies are encouraging.

Wendler Alexandra

2012-03-01

267

Maturidade perceptomotora e reconhecimento de palavras: estudo correlacional entre o Bender - Sistema de Pontuação Gradual e o Teste de Reconhecimento de Palavras / Perceptive-motor maturity and word recognition: a correlational study between Bender - Scoring System for Grades and Word Recognition test  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O presente estudo objetivou investigar evidências de validade para o Bender - Sistema de Pontuação Gradual, pela relação com o Teste de Reconhecimento de Palavras, partindo da premissa de que os testes apresentariam comunalidade em certos aspectos. Além disso, a pesquisa buscou verificar se o Bender [...] é sensível para captar diferenças de média por idade. Participaram do estudo 297 crianças, sendo 153 do sexo masculino (51,5%), com idade entre 7 e 10 anos (M=9,04, DP=0,88). Cursavam do 2º ao 5º ano do ensino fundamental, em escola particular (27,3%) ou pública (72,7%) do interior do estado de São Paulo. Os instrumentos foram aplicados coletivamente, sendo que as figuras do Bender foram projetadas. Foram evidenciadas correlações significativas entre os instrumentos. Verificou-se também que o Bender mostrou-se sensível em captar as diferenças relacionadas à idade, revelando o aspecto maturacional avaliado pelo teste, assim como também revelou relação com a escolaridade. Abstract in english The aim of this study was to investigate evidence of validity of the Bender - Scoring System for Grades, by comparison with the Word Recognition Test, starting with the premise that the tests would show commonality in certain aspects. In addition, the study sought to verify whether the B-SPG is sens [...] itive to capture differences in mean for age. The study participants included 297 children, 153 being boys (51.5%) aged between 7 and 10 years (M=9.04, SD=0.88). They were in the 2nd to the 5th year of elementary schooling, at private (27.3%) and public (72.7%) schools, in the interior of State of São Paulo. The instruments were applied collectively, and the Bender - Gradual Scoring System pictures were projected. Significant correlations were observed between the instruments. Furthermore, it was found that the Bender - Gradual Scoring System was shown to be sensitive in capturing differences related to age, revealing the aspect of maturity assessed by testing, and also revealed relationship with progress in school stages.

Carvalho, Laura de; Noronha, Ana Paula Porto; Pinto, Lariana Paula; Luca, Luana.

268

Relación entre el índice CHA2DS2-VASc y la presencia de trombo auricular en pacientes con fibrilación auricular en plan de cardioversión / Correlation Between CHA2DS2-VASc Score and Atrial Thrombus in Patients with Atrial Fibrillation Undergoing Cardioversion  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Introducción Los pacientes con fibrilación auricular representan un grupo de riesgo para el desarrollo de complicaciones tromboembólicas, con consecuencias devastadoras cuando afectan el sistema nervioso central. El rendimiento de los índices de riesgo para predecir eventos clínicos se ha evaluado e [...] n numerosas publicaciones, mientras que su relación con la presencia de trombo en la aurícula izquierda o su orejuela se ha explorado menos. Recientemente se ha propuesto la utilización del índice conocido con el acrónimo CHA2DS2-VASc para la estratificación de riesgo cardioembólico. Objetivo Evaluar la prevalencia de trombo en la aurícula izquierda y su relación con las variables del índice CHA2DS2-VASc y la función sistólica del ventrículo izquierdo en pacientes con fibrilación auricular que serán sometidos a cardioversión eléctrica. Material y métodos Se efectuó un registro prospectivo de los antecedentes clínicos de pacientes con fibrilación auricular de tiempo indeterminado o > 48 horas, a los que se les realizó un eco transesofágico previo a una cardioversión eléctrica. Se analizó la relación de las variables que conforman el índice CHA2DS2-VASc y del puntaje total para predecir trombo en el eco transesofágico. Se evaluó además un modelo que resultó de sumar al CHA2DS2-VASc un puntaje según la función sistólica del ventrículo izquierdo: normal = 0, deterioro leve = 1, moderado = 2, grave = 3. Resultados Se incluyeron 129 pacientes con edad media de 70 ± 12 años, de los cuales 21 (16%) presentaron trombo. Este hallazgo fue más prevalente en pacientes con factores de riesgo, pero alcanzó nivel de significación solo para insuficiencia cardíaca y diabetes. Se observó un incremento progresivo del riesgo de trombo en relación con el CHA2DS2-VASc (3,6 ± 1,6 con trombo vs. 2,7 ± 1 sin trombo; p = 0,024, área bajo la curva ROC = 0,65). La asociación se ve reforzada cuando se incluye la función sistólica del ventrículo izquierdo (p = 0,006, área bajo la curva ROC = 0,69). Un puntaje de CHA2DS2-VASc Abstract in english Background Patients with atrial fibrillation represent a group of risk for thromboembolic complications, with catastrophic consequences when affecting the central nervous system. The performance of risks scores to predict clinical events has been evaluated by several publications; yet, its correlati [...] on with the presence of thrombi in the left atrium or left atrial appendage has been poorly investigated. The use of the CHA2DS2-VASc score has been recently proposed for stratification of throm-boembolic risk. Objective To evaluate the prevalence of left atrial thrombus and its correlation with the components of the CHA2DS2-VASc score and with left ventricular systolic function in patients scheduled for electrical cardioversion. Methods A prospective registry of the medical history of patients with atrial fibrillation of unknown duration or lasting >48 hours, undergoing transesophageal echocardiography before scheduled electrical cardioversion was conducted. The correlation of the components of the CHA2DS2-VASc scores and of the total score with the presence of thrombi in transesophageal echocardiography was analyzed. The result of the sum of the CHA2DS2-VASc score plus a score of left ventricular systolic function (normal = 0, mild dysfunction = 1, moderate dysfunction = 2, severe dysfunction = 3) was also evaluated. Results A total of 129 patients (mean age 70±12 years) were included; 21 (16%) had thrombus. This finding was more prevalent in patients with risk factors, but was only statistically significant for heart failure and diabetes. The risk of thrombus in the LA/LAA progressively increased at higher CHA2DS2-VASc (3.6±1.6 with thrombus vs. 2.7±1 without thrombus; p = 0.024, area under the ROC curve = 0.65). This association was greater when left ventricular systolic function was included (p = 0.006, area under the ROC curve = 0.69). A CHA2DS2-VASc

Norberto G, Allende; Carlos, Rodríguez Pagani; Eduardo, Carrasco; Gerardo, Marmbio; Guillermo, López Soutric; Federico, Cintora; Fanny, Calvo; Ricardo, Pérez De La Hoz.

269

Bishop score and labor induction  

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Full Text Available Introduction Induction of labor represents initiation of uterine contractions before their spontaneous onset. The aim of the study was to establish the role of Bishop score in prediction of labor induction in routine clinical work. Material and methods The study was a prospective blind, observational one. All patients had a vaginal examination prior to induction, during which Bishop score was evaluated. The mode of induction was either intravenous infusion of oxytocin or endovaginal prostaglandins. The induction was considered successful if vaginal delivery took place within 24 hours from the onset of induction. Results There were 100 patients, and induction was successful in 74% and unsuccessful in 26%. Mean Bishop score in group A was 5.65 (SD 1.40, 95% CI 5.27 - 6.03, and in group B 4.15 (SD 1.04, 95% CI 3.66 - 4.63 (p < 0.01. Statistical analysis of the area under the ROC curve showed that Bishop score is a good and reliable predictor of the outcome of labor induction (0.816, 95% CI od 0.710 - 0.896, with the best statistical performances at the cut-off value of 5 (sensitivity 65.5% specificity 95%, PPV 97.3%, NPV 50%. Conclusion In our study Bishop score proved to be a reliable and good method for prediction of the outcome of pregnancy if a single, experienced operator evaluates it, with best statistical performances at the cut-off value more than 5 (sensitivity 65.5%, specificity 95%, PPV 97.3%, NPV 50%. The next step would be introduction of more operators, of different skills and experience and subsequent further testing of the method in different conditions.

Radeka Gordana

2002-01-01

270

Scoring systems for prediction of mortality in patients with intensive care unit-acquired sepsis: a comparison of the Pitt bacteremia score and the Acute Physiology and Chronic Health Evaluation II scoring systems.  

Science.gov (United States)

This study compares the effectiveness of the Pitt bacteremia score, the Charlson weighted index of comorbidity, and the Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring systems for the prediction of mortality in intensive care unit (ICU) patients with sepsis using the retrospective observational method on 134 patients with ICU-acquired sepsis. The statistical analyses show several important findings. First, Pitt bacteremia score is significantly correlated with the APACHE II scoring system (correlation coefficient = 0.738, P Pitt bacteremia score, and the Charlson weighted index of comorbidity are independently correlated with mortality. Third, the Pitt bacteremia score and the APACHE II scores are positively related to mortality in patients with ICU-acquired sepsis. As the result of the analyses, the mortality rate in patients with sepsis in the ICU is better predicted with the Pitt bacteremia score because it provides better estimation of sensitivity and specificity than the APACHE II scoring system and the Charlson weighted index of comorbidity. PMID:18636041

Rhee, Ji-Young; Kwon, Ki Tae; Ki, Hyun Kyun; Shin, Sang Yop; Jung, Dong Sik; Chung, Doo-Ryeon; Ha, Byoung-Chun; Peck, Kyong Ran; Song, Jae-Hoon

2009-02-01

271

Association between eating behavior scores and obesity in Chilean children  

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Full Text Available Abstract Background Inadequate eating behavior and physical inactivity contribute to the current epidemic of childhood obesity. The aim of this study was to assess the association between eating behavior scores and childhood obesity in Chilean children. Design and methods We recruited 126 obese, 44 overweight and 124 normal-weight Chilean children (6-12 years-old; both genders according to the International Obesity Task Force (IOTF criteria. Eating behavior scores were calculated using the Child Eating Behavior Questionnaire (CEBQ. Factorial analysis in the culturally-adapted questionnaire for Chilean population was used to confirm the original eight-factor structure of CEBQ. The Cronbach's alpha statistic (>0.7 in most subscales was used to assess internal consistency. Non-parametric methods were used to assess case-control associations. Results Eating behavior scores were strongly associated with childhood obesity in Chilean children. Childhood obesity was directly associated with high scores in the subscales "enjoyment of food" (P Conclusion Our study shows a strong and graded association between specific eating behavior scores and childhood obesity in Chile.

Amador Paola

2011-10-01

272

A novel cleansing score system for capsule endoscopy  

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Full Text Available AIM: To suggest a new cleansing score system for small bowel preparation and to evaluate its clinical efficacy.METHODS: Twenty capsule endoscopy cases were reviewed and small bowel preparation was assessed with the new scoring system. For the assessment, two visual parameters were used: proportion of visualized mucosa and degree of obscuration. Representative frames from small bowel images were serially selected and scored at 5-min intervals. Intraclass correlation coefficient (ICC was obtained to assess the reliability of the new scoring system. For efficacy evaluation and validation, scores of our new scoring system were compared with another previously reported cleansing grading system.RESULTS: Concordance with the previous system, inter-observer agreement, and intra-patient agreement were excellent with ICC values of 0.82, 0.80, and 0.76, respectively. The intra-observer agreements at four-week intervals were also excellent. The cut-off value of adequate image quality was found to be 2.25.CONCLUSION: Our new scoring system is simple, efficient, and can be considered to be applicable in clinical practice and research.

Sung Chul Park, Bora Keum, Jong Jin Hyun, Yeon Seok Seo, Yong Sik Kim, Yoon Tae Jeen, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu

2010-02-01

273

Doença de Kimura não é hiperplasia angiolinfóide com eosinofilia: correlação clinicopatológica com revisão da literatura e definição de critérios diagnósticos Kimura disease is not angiolymphoid hyperplasia with eosinophilia: clinical and pathological correlation with literature review and definition of diagnostic criteria  

Directory of Open Access Journals (Sweden)

Full Text Available A doença de Kimura é doença inflamatória crônica que se manifesta como crescimento tumoral indolor na região da cabeça e do pescoço, freqüentemente associada à linfoadenopatia cervical. Por ser doença rara, ter sido descrita inicialmente na literatura oriental e ter características em comum com a hiperplasia angiolinfóide com eosinofilia, a doença de Kimura tem sido confundida com essa enfermidade, da qual deve ser distinguida. Neste artigo, revisam-se as características clínicas e histopatológicas e apresentam-se critérios para a diferenciação dessas duas entidades.Kimura disease is a rare chronic inflammatory disease that presents as a tumor-like swelling in the head and neck region and is often associated with regional cervical lymphadenopathy. Cases have been described predominantly in the oriental literature. Kimura disease has been confused with angiolymphoid hyperplasia with eosinophilia, for having common characteristics, but both conditions should be differentiated. In this article, the clinical and histopathological characteristics are revised and the criteria to differentiate the two conditions are presented.

Pedro Leonardo Briggs

2006-03-01

274

Quantifying radioxerostomia: salivary flow rate, examiner's score, and quality of life questionnaire  

International Nuclear Information System (INIS)

Background and purpose: salivary flow rates alone are not sufficient to quantify all aspects of radioxerostomia. This is a problem in studies aiming to reduce radioxerostomia. The aim of this study was to evaluate the association between objectively measured salivary flow rate and subjective xerostomia ratings by the physician (RTOG scale) or the patients (quality of life [QoL] questionnaire). Patients and methods: in a case-control study patients who underwent recall for oral cancer were screened. Inclusion criteria for this diagnostic, noninterventional study were: history of oral carcinoma, surgical and radiation therapy, time interval from start of radiation therapy > 90 days, salivary glands within the radiation field. The control group consisted of patients, who had not received radiotherapy. RTOG salivary gland score, quality of life (EORTC QLQ-C30 and H and N35), and sialometry were recorded. Results: patients with RTOG score 0 had mean salivary flow rates of 0.3 ml/min, those with RTOG 1 0.12 ml/min, RTOG 2 0.02 ml/min, and RTOG 3 < 0.01 ml/min. RTOG score 4 (total fibrosis) did not occur. Based on salivary flow rates, all patients were grouped into xerostomia < 0.2 ml/min (30 patients) and nonxerostomia (twelve patients). QoL results revealed significant differences between patients with xerostomia and nonxerostomia for physical function, dyspnea, swallowing, social eating, dry mouth, nutritional support, and a tendency to higher values for appetite loss. Conclusion: the correlation between ''subjective'' QoL parameters and salivary flow was confirmed. The different subjective aspects of radioxerostomia seem to be better differentiated by the EORTC QoL questionnaire. (orig.)

2006-06-01

275

A study to validate the method based on DIMOND quality criteria for cardiac angiographic images  

International Nuclear Information System (INIS)

A method based on image quality criteria (QC) for cine-angiography was developed to measure the quality of cine-angiograms (CA). A series of 30 CA for left ventriculography (LV) and left and right coronary angiography (LCA, RCA) have been scored and 172 readings were obtained. Standard deviation of quality scores indicated the reproducibility of the method. Each part of CA was examined separately, giving scores for LV, LCA and RCA and a total score (TS), with clinical (C) and technical (T) criteria defined and examined separately. In 83% of the studies TS was >0.8 and with standard deviation from 0.02 to 0.21. In general, LV had a lower score and greater disagreement compared with RCA and LCA. Disagreement was greater in T, compared with C. In conclusion, these results indicate that QC, translated into a scoring system, yields reproducible data on the quality of cardiac images. (authors)

2004-03-25

276

Credit Scoring Model Hybridizing Artificial Intelligence with Logistic Regression  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Today the most commonly used techniques for credit scoring are artificial intelligence and statistics. In this paper, we started a new way to use these two kinds of models. Through logistic regression filters the variables with a high degree of correlation, artificial intelligence models reduce complexity and accelerate convergence, while t...

2013-01-01

277

Concurrent Validity and Reliability of Retrospective Scoring of the Pediatric NIH Stroke Scale  

Science.gov (United States)

Background and Purpose The Pediatric National Institutes of Health Stroke Scale (PedNIHSS), an adaptation of the adult NIH Stroke Scale, is a quantitative measure of stroke severity shown to be reliable when scored prospectively. The ability to calculate the PedNIHSS score retrospectively would be invaluable in the conduct of observational pediatric stroke studies. The study objective was to assess the concurrent validity and reliability of estimating the PedNIHSS score retrospectively from medical records. Methods Neurological examinations from medical records of 75 children enrolled in a prospective PedNIHSS validation study were photocopied. Four neurologists of varying training levels blinded to the prospective PedNIHSS scores reviewed the records and retrospectively assigned PedNIHSS scores. Retrospective scores were compared among raters and to the prospective scores. Results Total retrospective PedNIHSS scores correlated highly with total prospective scores (R2=0.76). Interrater reliability for the total scores was “excellent” (intraclass correlation coefficient of 0.95, 95% confidence interval 0.94–0.97). Interrater reliability for individual test items was “substantial” or “excellent” for 14 of 15 items. Conclusions The PedNIHSS score can be scored retrospectively from medical records with a high degree of concurrent validity and reliability. This tool can be used to improve the quality of retrospective pediatric stroke studies.

Beslow, Lauren A.; Kasner, Scott E.; Smith, Sabrina E.; Mullen, Michael T.; Kirschen, Matthew P.; Bastian, Rachel A.; Dowling, Michael M.; Lo, Warren; Jordan, Lori C.; Bernard, Timothy J.; Friedman, Neil; deVeber, Gabrielle; Kirton, Adam; Abraham, Lisa; Licht, Daniel J.; Jawad, Abbas F.; Ellenberg, Jonas H.; Lautenbach, Ebbing; Ichord, Rebecca N.

2011-01-01

278

EDUCATION AND PSYCHOLOGICAL TEST SCORES  

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Education, a long neglected variable affecting psychological test score, is in search of reemphasis. Some evidence for this has accumulated on the psychological tests constructed and standardized here at the department of Psychiatry, P.G.I., Chandigarh. Tentative norms prepared education wise on WAIS-Verbal section, PGI-Memory Scale, Proverb and Similarity Tests, Psychoticism Questionnaire, and PGI MQN 2, for adults, in the age range of 16-50, are reported. The results showed marked differenc...

1980-01-01

279

Bootstrapping Manski's Maximum Score Estimator  

CERN Document Server

In this paper we study the applicability of the bootstrap to do inference on Manski's maximum score estimator under the full generality of the model. We propose three new, model-based bootstrap procedures for this problem and show their consistency. Simulation experiments are carried out to evaluate their performance and to compare them with subsampling methods. Additionally, we prove a uniform convergence theorem for triangular arrays of random variables coming from binary choice models, which may be of independent interest.

Seijo, Emilio

2011-01-01

280

Item Response Modeling with Sum Scores  

Science.gov (United States)

One of the distinctions between classical test theory and item response theory is that the former focuses on sum scores and their relationship to true scores, whereas the latter concerns item responses and their relationship to latent scores. Although item response theory is often viewed as the richer of the two theories, sum scores are still…

Johnson, Timothy R.

2013-01-01

 
 
 
 
281

Model Selection Criteria Using Divergences  

Directory of Open Access Journals (Sweden)

Full Text Available In this note we introduce some divergence-based model selection criteria. These criteria are defined by estimators of the expected overall discrepancy between the true unknown model and the candidate model, using dual representations of divergences and associated minimum divergence estimators. It is shown that the proposed criteria are asymptotically unbiased. The influence functions of these criteria are also derived and some comments on robustness are provided.

Aida Toma

2014-05-01

282

Sustainable Criteria for Environmental Technology  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The demand for sustainable criteria for environmental technology has over the past few years increaseddue to competition amongst companies in the business due to legal demands. Using criteria for environmentaltechnology is a way for companies to show buyers that their product is a long term investment. Byimplementing sustainable criteria for environmental technology, companies can be sure they are buying andusing the best available technology adjusted to their economy. Sustainable criteria fo...

Kjellberg, Kristin

2004-01-01

283

The relationship between serum bilirubin level with interleukin-6, interleukin-10 and mortality scores in patients with sepsis.  

Science.gov (United States)

Context: Bilirubin has been shown to influence the mechanisms of both apoptosis and inflammation. Aims: The aim of the following study is to investigate the relationship between the serum bilirubin level with sepsis progression. Settings and Design: A total of 20 patients from intensive care unit were included for this study. Materials and Methods: Patients were divided into two groups: Patients diagnosed with sepsis according to the American College of Chest Physicians/Society of Clinical Care Medicine consensus conference criteria (n0 = 10) and patients treated for various other diagnoses ( n = 10). Blood samples were collected for both groups at the time of origin (defined as the time of diagnosis) and 24 and 48 h after diagnosis. Serum interleukin (IL)-6, IL-10 and bilirubin levels were analyzed and compared. Acute physiology and chronic health evaluation (APACHE) II and sepsis related organ failure (SOFA) scores of the patients were also evaluated. Statistical Analysis Used: We used Statistical Package for Social Sciences (SPSS for Windows, version 17.0, SPSS Inc. 233 South Wacker Drive, Chicago) for statistical analysis. Results: At all-time intervals, serum IL-6, IL-10 and total, direct and indirect serum bilirubin levels were significantly higher in the sepsis group ( P sepsis group, only SOFA score and bilirubin levels were correlated. Because bilirubin is already a SOFA parameter, this correlation was not considered as clinically significant. PMID:24909480

Tutak, E; Ozer, A B; Demirel, I; Bayar, M K

2014-01-01

284

Scoring of the Physical Therapist Clinical Performance Instrument (PT-CPI): Analysis of 7 Years of Use  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Purpose: The aims of this study were to (1) describe the completion rates of the 24 performance criteria (PCs) from the Physical Therapist Clinical Performance Instrument (PT-CPI) by clinical instructors; (2) evaluate change in PC visual analogue scores (VAS) with students' clinical experience; and (3) evaluate scoring patterns over time.

Proctor, Peggy L.; Dal Bello-haas, Vanina P.; Mcquarrie, Arlis M.; Sheppard, M. Suzanne; Scudds, Rhonda J.

2010-01-01

285

Using the Skindex-16 and Common Terminology Criteria for Adverse Events to assess rash symptoms: results of a pooled-analysis (N0993)  

Science.gov (United States)

Background Historically, skin toxicity has been assessed in prospective clinical trials using the clinician-reported National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE). The patient-reported Skindex-16 measures symptoms and perceptions of toxicity. This study was designed to compare information provided by these two measures. Methods Data were compiled from three placebo-controlled North Central Cancer Treatment Group studies (N06C4, N03CB, N05C4) having rash prevention as the primary objective. All used the Skindex-16 and CTCAE at baseline, weekly during treatment and during a minimum 2-week follow-up period. Statistical procedures, including Pearson correlations, were utilized to determine relationships between adverse event (AE) grades and Skindex-16 scores. Results Four hundred and twelve individual patients provided data (median age, 61; 134 male). Patients’ Skindex-16 score results show a 0.9 overall mean (range 0–6 with 6 being worse symptoms), a 0.4 baseline mean (range, 0–4.3) and a 1.3 end-of-treatment mean (range, 0–5.9). Ninety-three, 142 and 177 patients experienced a grade 0, 1 and 2+ CTCAE skin toxicity, respectively. Baseline Skindex-16 scores had relatively low correlation with CTCAE grades. The correlation of rash grade with Skindex-16 scores ranged from r=0.49 with the function subscale to r=0.62 with the symptom subscale. The highest correlations of the maximum grade of any dermatological AE with the Skindex-16 were r=0.48 for the total score and r=0.55 for the symptom subscale. Conclusions The data reported support the decision to include both measures in a clinical trial to assess the patient experience, as each measure may specifically target varying symptoms and intensities.

Burger, Kelli N.; Loprinzi, Charles L.; Wittich, Michelle A. Neben; Miller, Robert C.; Jatoi, Aminah; Sloan, Jeff A.

2012-01-01

286

Assessment of the pathological grade of astrocytic gliomas using an MRI score  

International Nuclear Information System (INIS)

To evaluate the usefulness of an MRI score for identifying tumour tissue characteristics, 41 histologically verified supratentorial astrocytic gliomas, including 13 low-grade astrocytomas 14 anaplastic astrocytomas and 14 glioblastoma multiformes, were examined with a 0.5 T superconductive MR imager. Nine MRI criteria were used: heterogeneity, cyst formation or necrosis, haemorrhage, crossing the midline, oedema or mass effect, border definition, flow void, degree and heterogeneity of contrast enhancement; Gd-enhanced T1-weighted images were obtained in 32 cases. Each of the criteria was scored and analysed statistically. (orig./MG)

1994-05-01

287

Value of coronary artery calcium score to predict severity or complexity of coronary artery disease  

Science.gov (United States)

Background Prediction of severity or complexity of coronary artery disease (CAD) is valuable owing to increased risk for cardiovascular events. Although the association between total coronary artery calcium (CAC) score and severity of CAD, Gensini score was not used, it has been previously demonstrated. There is no information about the association between total CAC score and complexity of CAD. Objectives To investigate the association between severity or complexity of coronary artery disease (CAD) assessed by Gensini score and SYNTAX score (SS), respectively, and coronary artery calcium (CAC) score, which is a noninvasive method for CAD evaluation in symptomatic patients with accompanying significant CAD. Methods Two-hundred-fourteen patients were enrolled. Total CAC score was obtained before angiography. Severity and complexity of CAD was assessed by Gensini score and SS, respectively. Associations between clinical and angiographic parameters and total CAC score were analyzed. Results Median total CAC score was 192 (23.0-729.8), and this was positively correlated with both Gensini score (r: 0.299, p 809 for SS >32 (high SS tertile). Conclusion In symptomatic patients with accompanying significant CAD, total CAC score was independently associated with SS and patients with SS >32 may be detected through high Agatston score.

Gokdeniz, Tayyar; Kalayc?oglu, Ezgi; Aykan, Ahmet Cagr?; Boyac?, Faruk; Turan, Turhan; Gul, Ilker; Cavusoglu, Gokhan; Dursun, Ihsan

2014-01-01

288

Laser Safety Inspection Criteria  

International Nuclear Information System (INIS)

A responsibility of the Laser Safety Officer (LSO) is to perform laser safety audits. The American National Standard Z136.1 Safe use of Lasers references this requirement in several sections: (1) Section 1.3.2 LSO Specific Responsibilities states under Hazard Evaluation, ''The LSO shall be responsible for hazards evaluation of laser work areas''; (2) Section 1.3.2.8, Safety Features Audits, ''The LSO shall ensure that the safety features of the laser installation facilities and laser equipment are audited periodically to assure proper operation''; and (3) Appendix D, under Survey and Inspections, it states, ''the LSO will survey by inspection, as considered necessary, all areas where laser equipment is used''. Therefore, for facilities using Class 3B and or Class 4 lasers, audits for laser safety compliance are expected to be conducted. The composition, frequency and rigueur of that inspection/audit rests in the hands of the LSO. A common practice for institutions is to develop laser audit checklists or survey forms. In many institutions, a sole Laser Safety Officer (LSO) or a number of Deputy LSO's perform these audits. For that matter, there are institutions that request users to perform a self-assessment audit. Many items on the common audit list and the associated findings are subjective because they are based on the experience and interest of the LSO or auditor in particular items on the checklist. Beam block usage is an example; to one set of eyes a particular arrangement might be completely adequate, while to another the installation may be inadequate. In order to provide more consistency, the National Ignition Facility Directorate at Lawrence Livermore National Laboratory (NIF-LLNL) has established criteria for a number of items found on the typical laser safety audit form. These criteria are distributed to laser users, and they serve two broad purposes: first, it gives the user an expectation of what will be reviewed by an auditor, and second, it is an opportunity to explain audit items to the laser user and thus the reasons for some of these items. Some examples are given from the audit criteria handout. As an explanatory key to the reader, an Operational Safety Procedure (OSP) as a formally reviewed safety procedure required for all Class 3B and Class 4 laser installations. An ''OSP Binder'' contains all safety documentation related to a given laser operation and serves as a central repository for documents, such as the OSP, interlock logs, lessons learned, contact information etc. ''Unattended Operation'' refers to approved procedures for unattended operation of the laser installation and may include operation beyond normal working hours. ''L-train'' is the LLNL training tracking system

2005-03-05

289

Scoring of treatment-related late effects in prostate cancer  

International Nuclear Information System (INIS)

Background and purpose: To assess the correlation between different general and organ specific quality of life and morbidity scoring methods in a cohort of men treated with radical radiotherapy for prostate cancer. Materials and methods: Men who had been treated with radical radiotherapy (50 Gy in 16 fractions over 21 days) for localized prostate cancer more than 3 years previously and who had no evidence of recurrent disease were invited to take part in the study. A total of 101 of 135 invited patients agreed and completed LENT/SOMA, UCLA Prostate Cancer Index, and 36 item RAND Health survey questionnaires. Results: The patients had comparable results with other published series with respect to the UCLA and SF-36 indices. There was significant correlation between the corresponding parts of the UCLA and LENT/SOMA scales (P<0.0005). However, for the same symptoms, a patient tended to score lower (worse) on the UCLA scale in comparison to LENT/SOMA. The relationship between the average LENT/SOMA score and maximum score was also not straightforward with each set of data revealing different information. Conclusions: The LENT/SOMA questions were, in the main, more wide-ranging and informative than the UCLA index. It is helpful to give both the overall and maximum LENT/SOMA scores to most efficiently use all of the data. There may need to be a further LENT/SOMA question to allow both symptoms of tenesmus and faecal urgency to be fully addressed

2002-11-01

290

Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity  

Directory of Open Access Journals (Sweden)

Full Text Available Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. However, there is no gold standard to measure the disease activity in clinical trials. In this study we aimed to introduce the pemphigus vulgaris activity score (PVAS measurement and to assess the convergent validity with the experts’ opinion of disease activity. In PVAS scoring, the distribution of pemphigus vulgaris antigen expression in different anatomical regions is taking in to account with special consideration of the healing process. PVAS is a 0-18 scale, based on the extent of mucocutaneous involvement, type of lesion and the presence of Nikolsky’s sign. The sum of the scores of total number of lesions, number of different anatomic regions involvement and Nikolsky’s sign is weighted by the type of lesion. In the present study, PVAS was assessed in 50 patients diagnosed with pemphigus vulgaris by one dermatologist. Independently, five blinded experts scored all the patients through physician’s global assessment (PGA. The convergent validity with experts’ opinion was assessed. The Spearman coefficient of correlation showed the acceptable value of 0.751 (95%CI: 0.534- 0.876. PVAS is a valid, objective and simple-to-use scoring measurement. It showed a good correlation with PGA of pemphigus disease activity in Iranian patients with pemphigus vulgaris

Cheyda Chams-Davatchi

2013-04-01

291

Contrast-detail phantom scoring methodology.  

Science.gov (United States)

Published results of medical imaging studies which make use of contrast detail mammography (CDMAM) phantom images for analysis are difficult to compare since data are often not analyzed in the same way. In order to address this situation, the concept of ideal contrast detail curves is suggested. The ideal contrast detail curves are constructed based on the requirement of having the same product of the diameter and contrast (disk thickness) of the minimal correctly determined object for every row of the CDMAM phantom image. A correlation and comparison of five different quality parameters of the CDMAM phantom image determined for obtained ideal contrast detail curves is performed. The image quality parameters compared include: (1) contrast detail curve--a graph correlation between "minimal correct reading" diameter and disk thickness; (2) correct observation ratio--the ratio of the number of correctly identified objects to the actual total number of objects multiplied by 100; (3) image quality figure--the sum of the product of the diameter of the smallest scored object and its relative contrast; (4) figure-of-merit--the zero disk diameter value obtained from extrapolation of the contrast detail curve to the origin (e.g., zero disk diameter); and (5) k-factor--the product of the thickness and the diameter of the smallest correctly identified disks. The analysis carried out showed the existence of a nonlinear relationship between the above parameters, which means that use of different parameters of CDMAM image quality potentially can cause different conclusions about changes in image quality. Construction of the ideal contrast detail curves for CDMAM phantom is an attempt to determine the quantitative limits of the CDMAM phantom as employed for image quality evaluation. These limits are determined by the relationship between certain parameters of a digital mammography system and the set of the gold disks sizes in the CDMAM phantom. Recommendations are made on selections of CDMAM phantom regions which should be used for scoring at different image quality and which scoring methodology may be most appropriate. Special attention is also paid to the use of the CDMAM phantom for image quality assessment of digital mammography systems particularly in the vicinity of the Nyquist frequency. PMID:15839353

Thomas, Jerry A; Chakrabarti, Kish; Kaczmarek, Richard; Romanyukha, Alexander

2005-03-01

292

EuroSCORE II e a importância de um modelo local, InsCor e o futuro SP-SCORE / EuroSCORE II and the importance of a local model, InsCor and the future SP-SCORE  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Introdução: O modelo mais utilizado para predição de mortalidade em cirurgia cardíaca foi recentemente remodelado, mas dúvidas referentes à sua metodologia e desenvolvimento têm sido relatadas. Objetivo: O objetivo deste estudo foi avaliar o desempenho do EuroSCORE II na predição de mortalidade e [...] m pacientes submetidos a cirurgia de coronária e/ou valva na instituição. Métodos: Mil pacientes, operados consecutivamente de coronária e/ou valva, entre outubro de 2008 e julho de 2009, foram analisados. O desfecho de interesse foi mortalidade intra-hospitalar. A calibração foi realizada pela correlação entre mortalidade esperada e observada por meio do teste de Hosmer Lemeshow. A discriminação foi calculada pela área abaixo da curva ROC. O desempenho do EuroSCORE II foi comparado com os modelos EuroSCORE e InsCor (modelo local). Resultados: Na calibração, o teste de Hosmer Lemeshow foi inadequado para o EuroSCORE II (P=0,0003) e bom para os modelos EuroSCORE (P=0,593) e InsCor (P=0,184). No entanto, na discriminação, a área abaixo da curva ROC para o EuroSCORE II foi de 0,81 [IC 95% (0,76-0,85), P Abstract in english Introduction: The most widely used model for predicting mortality in cardiac surgery was recently remodeled, but the doubts regarding its methodology and development have been reported. Objective: The aim of this study was to assess the performance of the EuroSCORE II to predict mortality in pati [...] ents undergoing coronary artery bypass grafts or valve surgery at our institution. Methods: One thousand consecutive patients operated on coronary artery bypass grafts or valve surgery, between October 2008 and July 2009, were analyzed. The outcome of interest was in-hospital mortality. Calibration was performed by correlation between observed and expected mortality by Hosmer Lemeshow. Discrimination was calculated by the area under the ROC curve. The performance of the EuroSCORE II was compared with the EuroSCORE and InsCor (local model). Results: In calibration, the Hosmer Lemeshow test was inappropriate for the EuroSCORE II (P=0.0003) and good for the EuroSCORE (P=0.593) and InsCor (P=0.184). However, the discrimination, the area under the ROC curve for EuroSCORE II was 0.81 [95% CI (0.76 to 0.85), P

Luiz Augusto Ferreira, Lisboa; Omar Asdrubal Vilca, Mejia; Luiz Felipe Pinho, Moreira; Luís Alberto Oliveira, Dallan; Pablo Maria Alberto, Pomerantzeff; Luís Roberto Palma, Dallan; Maria Raquel B., Massoti; Fabio B., Jatene.

293

Decision criteria in PSA applications  

International Nuclear Information System (INIS)

Along with the adoption of risk informed decision making principles, the need for formal probabilistic decision rule or criteria has been risen. However, there are many practical and theoretical problems in the application of probabilistic criteria. One has to think what is the proper way to apply probabilistic rules together with deterministic ones and how the criteria are weighted with respect to each other. In this report, we approach the above questions from the decision theoretic point of view. We give a short review of the most well known probabilistic criteria, and discuss examples of their use. We present a decision analytic framework for evaluating the criteria, and we analyse how the different criteria behave under incompleteness or uncertainty of the PSA model. As the conclusion of our analysis we give recommendations on the application of the criteria in different decision situations. (au)

2001-01-01

294

Decision criteria in PSA applications  

Energy Technology Data Exchange (ETDEWEB)

Along with the adoption of risk informed decision making principles, the need for formal probabilistic decision rule or criteria has been risen. However, there are many practical and theoretical problems in the application of probabilistic criteria. One has to think what is the proper way to apply probabilistic rules together with deterministic ones and how the criteria are weighted with respect to each other. In this report, we approach the above questions from the decision theoretic point of view. We give a short review of the most well known probabilistic criteria, and discuss examples of their use. We present a decision analytic framework for evaluating the criteria, and we analyse how the different criteria behave under incompleteness or uncertainty of the PSA model. As the conclusion of our analysis we give recommendations on the application of the criteria in different decision situations. (au)

Holmberg, J.E.; Pulkkinen, U.; Rosqvist, T.; Simola, K. [VTT Automation (Finland)

2001-11-01

295

Bias Adjusted Precipitation Threat Scores  

Directory of Open Access Journals (Sweden)

Full Text Available Among the wide variety of performance measures available for the assessment of skill of deterministic precipitation forecasts, the equitable threat score (ETS might well be the one used most frequently. It is typically used in conjunction with the bias score. However, apart from its mathematical definition the meaning of the ETS is not clear. It has been pointed out (Mason, 1989; Hamill, 1999 that forecasts with a larger bias tend to have a higher ETS. Even so, the present author has not seen this having been accounted for in any of numerous papers that in recent years have used the ETS along with bias "as a measure of forecast accuracy".

A method to adjust the threat score (TS or the ETS so as to arrive at their values that correspond to unit bias in order to show the model's or forecaster's accuracy in extit{placing} precipitation has been proposed earlier by the present author (Mesinger and Brill, the so-called dH/dF method. A serious deficiency however has since been noted with the dH/dF method in that the hypothetical function that it arrives at to interpolate or extrapolate the observed value of hits to unit bias can have values of hits greater than forecast when the forecast area tends to zero. Another method is proposed here based on the assumption that the increase in hits per unit increase in false alarms is proportional to the yet unhit area. This new method removes the deficiency of the dH/dF method. Examples of its performance for 12 months of forecasts by three NCEP operational models are given.

F. Mesinger

2008-04-01

296

Ecoregional biological criteria  

Energy Technology Data Exchange (ETDEWEB)

For the purposes of the paper, biocriteria are defined as numerical values that describe the biological health of aquatic communities for a designated aquatic life use. Regardless of whether they are implemented regionally or site specifically, biocriteria (ambient, community-based) have the following advantages compared to chemical and toxicological criteria: biocriteria facilitate direct assessment of designated aquatic life uses, are applicable to a wide range of stressors (physical, chemical, biological, point, nonpoint, toxic, nontoxic), and provide a firm basis for regulating nonchemical degradation and antidegradation. They offer a mechanism for evaluating long-term effects of spills, process changes, and illegal dumping; for assessing cumulative effects of multiple dischargers and stressors; and for estimating bioaccumulation and indirect effects (food chain, competition, predation, migration, life history).

Hughes, R.M.

1989-01-01

297

Evaluation of the association between AT1R1166C polymorphism and the incidence of cad and CAC score in the Iranian population  

Directory of Open Access Journals (Sweden)

Full Text Available Most of the physiological effects of Ag II are mediated by the angiotensin II type 1 receptor. Polymorphisms of the AT1R gene can affect the function of this receptor and subsequent atherogenic activity. In this study we investigated the correlation between AT1R A1166C polymorphism and coronary artery calcification (CAC, a marker of the coronary artery burden. Fifty CAD patients and fifty healthy individuals fulfilled the inclusion and exclusion criteria entered this study. CAC was determined in the left main coronary artery (LMCA, left coronary artery (LCA, right coronary artery (RCA and CX by CT-angiography and a blood sample was taken at this time. DNA extracted from whole blood leukocytes was analyzed by the polymerase chain reaction - restriction fragment-length polymorphism (PCR-RFLP assay. There were no significant differences in genotype and allele frequencies between the CAD and control groups. The mean calcium score was compared in genotypes and alleles and no significant difference was seen. In addition, the frequency of genotypes and alleles was not significantly different in the calcium score groups (low<100, medium= 100-400, high >400. An analysis was performed separately in males and females and no significant correlation was found. According to our results, no association was found between AT1R1166C polymorphism and the incidence of CAD and CAC score in our study population.

Mohammadpour Hooshang Amir

2012-01-01

298

Observed score equating with covariates  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In test score equating the focus is on the problem of finding the relationship between the scales of different test forms. This can be done only if data are collected in such a way that the effect of differences in ability between groups taking different test forms can be separated from the effect of differences in test form difficulty. In standard equating procedures this problem has been solved by using common examinees or common items. With common examinees, as in the equivalent groups des...

Bra?nberg, Kenny

2010-01-01

299

Shwachman-Kulczycki score still useful to monitor cystic fibrosis severity  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english INTRODUCTION: The Shwachman-Kulczycki score was the first scoring system used in cystic fibrosis to assess disease severity. Despite its subjectivity, it is still widely used. OBJECTIVE: To study correlations among forced expiratory volume in one second (FEV1), chest radiography, chest computed tomo [...] graphy, 6-minute walk test, and Shwachman-Kulczycki score in patients with cystic fibrosis and to test whether the Shwachman-Kulczycki score is still useful in monitoring the severity of the disease. METHODS: A cross-sectional prospective study was performed to analyze the correlations (Spearman). Patients with clinically stable cystic fibrosis, aged 3-21 years, were included. RESULTS: 43 patients, 19F/24M, mean age 10.5 + 4.7 years, with a median Shwachman-Kulczycki score of 70 were studied. The median Brasfield and Bhalla scores were 17 and 10, respectively. The mean Z score for the 6-minute walk test was -1.1 + 1.106 and the mean FEV1 was 59 + 26 (as percentage of predicted values). The following significant correlations versus the Shwachman-Kulczycki score were found: FEV1 (r = 0.76), 6-minute walk test (r = 0.71), chest radiography (r = 0.71) and chest computed tomography (r = -0.78). When patients were divided according to FEV1, a statistically significantly correlation with the Shwachman-Kulczycki score was found only in patients with FEV1

Stollar, Fabíola; Adde, Fabíola Villac; Cunha, Maristela T.; Leone, Claudio; Rodrigues, Joaquim C..

300

Correlação entre Inventário de Depressão de Beck e cortisol urinário em diabéticos tipo 2 Correlación entre el inventario de Depresión de Beck y el cortisol urinario en diabeticos tipo 2 Correlation between urine cortisol and scores on the Beck Depression inventory in patients with type 2 diabetes  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVO: Verificar a correlação entre o cortisol urinário e o Inventário de Depressão de Beck em diabéticos do tipo 2. MÉTODOS: O cortisol urinário foi avaliado em uma amostra composta por 40 pacientes da Liga de Controle de Diabetes da Disciplina de Endocrinologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo e para a avaliação dos sintomas de depressão foi aplicado o Inventário de Depressão de Beck. RESULTADOS: Alta confiabilidade para o Inventário de Depressão de Beck(Alfa de Cronbach=0,920e correlação significativa foi observada entre cortisol urinário e Inventário de Depressão de Beck(Spearman,r=0.523,pOBJETIVO: Verificar la correlación entre el cortisol urinario y el Inventario de Depresión de Beck en diabéticos del tipo 2. MÉTODOS: El cortisol urinario fue evaluado en una muestra compuesta por 40 pacientes de la Liga de Control de Diabetes de la Disciplina de Endocrinología del Hospital de las Clínicas de la Facultad de Medicina de la Universidad de Sao Paulo y para la evaluación de los síntomas de depresión fue aplicado el Inventario de Depresión de Beck. RESULTADOS: Alta confiabilidad para el Inventario de Depresión de Beck(Alfa de Cronbach=0,920 y correlación significativa observada entre el cortisol urinario e Inventario de Depresión de Beck (Spearman,r=0.523,pOBJECTIVE: To determine the relationship between urinary cortisol and scores on the Beck Depression Inventory in type 2 diabetics. METHODS: The sample consisted of 40 patients with type 2 diabetes from the diabetes control league of the discipline of endocrinology of the HCFM-USP. Measures consisted of urinary cortisol and depression symptoms using the Beck Depression Inventory. RESULTS: The Beck Depression Inventory had a Cronbach's alpha of 0.92. There was a statistically significant correlation between urinary cortisol and scores on the Beck Depression Inventory (Spearman r = 0.52, p < .001. CONCLUSIONS: The Beck Depression Inventory was found to be a reliable indicator of depressive symptoms in patients with type 2 diabetes. Urine cortisol is associated with the presence of depressive symptoms.

Alexandra Bulgarelli do Nascimento

2009-01-01

 
 
 
 
301

An Iranian scoring system for diagnosing Buerger's disease.  

Science.gov (United States)

Buerger's disease or thromboangiitis obliterans (TAO) seems to be common in IR Iran, The present study aimed to evaluate an Iranian population with Buerger's disease in order to suggest a diagnostic criterion for Buerger's disease based on the most frequent findings and to compare it with Papa diagnostic criteria. In a cross-sectional study, all patients with resting limb pain, limb ischemic ulcers, intermittent claudication and limb ischemia who referred to the Vascular Clinic of Sina Hospital during 2009-2011 were evaluated. The patients were allocated to Buerger's and non-Buerger's groups; Evaluating 122 patients (61 in each group), according to the model each clinical manifestations and risk factors in the patients with Buerger's disease obtained a score. Absent pulsation, abnormal distal Doppler sonography and ischemic ulcer were respectively present in 58 (95.1%), 58 (95.1%) and 49 (80.3%) individuals with Buerger's disease. Multivariate linear regression analysis and multivariate logistic regression analysis were used for modeling. Considering the model finding findings, diagnostic criteria including age, sex, smoking, Raynaud's phenomenon, abnormal proximal Doppler, diabetes mellitus and hyperlipidemia were suggested (R2=0.582); the sensitivity and specificity of the criteria was respectively 95.1% and 78.7%. Compared with Papa criteria, Kappa coefficient was measured at 0.66 with a P-value<0.001. It seems that the recommended criteria have an acceptable accuracy in diagnosing Buerger's disease, especially in the Iranian population; however, it is necessary to conduct more studies with larger sample sizes to evaluate the criteria, especially in other populations. PMID:24658990

Ramin, Mohammad; Salimi, Javad; Meysamie, Alipasha

2014-01-01

302

Observed Score and True Score Equating Procedures for Multidimensional Item Response Theory  

Science.gov (United States)

The purpose of this research was to develop observed score and true score equating procedures to be used in conjunction with the multidimensional item response theory (MIRT) framework. Three equating procedures--two observed score procedures and one true score procedure--were created and described in detail. One observed score procedure was…

Brossman, Bradley G.; Lee, Won-Chan

2013-01-01

303

Limitations of electrocardiographic scoring systems for estimation of left ventricular function  

International Nuclear Information System (INIS)

Four electrocardiographic scoring systems for the assessment of left ventricular function or presence of myocardial infarction were evaluated in 231 patients with coronary artery disease. Electrocardiographic scores were compared with radionuclide ejection fraction and thallium perfusion studies. The correlation between Wagner's modified QRS score and ejection fraction was only fair (r . -0.60). Askenazi's sum of R wave voltage score correlated poorly with ejection fraction (r . 0.44), as did Gottwik's sum of voltage score from the Frank lead electrocardiogram (r . 0.44). Rautaharju's Cardiac Infarction Injury Score did not reliably predict presence of infarction in the patient group, nor did it correlate well with ejection fraction (r . -0.49). None of the correlations were significantly improved when only patients with a history of a myocardial infarction, a thallium defect compatible with a scar or a diagnostic Q wave were considered. Although Wagner's QRS score correlated best with ejection fraction, all scoring systems had limited clinical usefulness for estimating ejection fraction

1983-01-01

304

Score lists in multipartite hypertournaments  

CERN Multimedia

Given non-negative integers $n_{i}$ and $\\alpha_{i}$ with $0 \\leq \\alpha_{i} \\leq n_i$ $(i=1,2,...,k)$, an $[\\alpha_{1},\\alpha_{2},...,\\alpha_{k}]$-$k$-partite hypertournament on $\\sum_{1}^{k}n_{i}$ vertices is a $(k+1)$-tuple $(U_{1},U_{2},...,U_{k},E)$, where $U_{i}$ are $k$ vertex sets with $|U_{i}|=n_{i}$, and $E$ is a set of $\\sum_{1}^{k}\\alpha_{i}$-tuples of vertices, called arcs, with exactly $\\alpha_{i}$ vertices from $U_{i}$, such that any $\\sum_{1}^{k}\\alpha_{i}$ subset $\\cup_{1}^{k}U_{i}^{\\prime}$ of $\\cup_{1}^{k}U_{i}$, $E$ contains exactly one of the $(\\sum_{1}^{k} \\alpha_{i})!$ $\\sum_{1}^{k}\\alpha_{i}$-tuples whose entries belong to $\\cup_{1}^{k}U_{i}^{\\prime}$. We obtain necessary and sufficient conditions for $k$ lists of non-negative integers in non-decreasing order to be the losing score lists and to be the score lists of some $k$-partite hypertournament.

Pirzada, Shariefuddin; Iványi, Antal

2010-01-01

305

Disease Severity Indexes and Treatment Evaluation Criteria in Vitiligo  

Science.gov (United States)

There is a current lack of consensus regarding methods of assessment of vitiligo. Recently, the Vitiligo Area Scoring Index (VASI) and the Vitiligo European Task Force (VETF) were proposed to offer more accurate measures of disease severity indexes and treatment evaluation criteria. It would make sense to combine the VASI with the VETF system. We proposed an original scale for treatment evaluation criteria in vitiligo based on VASI. We plan to add the digital image analysis system, health-related quality of life questionnaire, affected skin location, and skin color in the original scale.

Kawakami, Tamihiro; Hashimoto, Takashi

2011-01-01

306

Disease severity indexes and treatment evaluation criteria in vitiligo.  

Science.gov (United States)

There is a current lack of consensus regarding methods of assessment of vitiligo. Recently, the Vitiligo Area Scoring Index (VASI) and the Vitiligo European Task Force (VETF) were proposed to offer more accurate measures of disease severity indexes and treatment evaluation criteria. It would make sense to combine the VASI with the VETF system. We proposed an original scale for treatment evaluation criteria in vitiligo based on VASI. We plan to add the digital image analysis system, health-related quality of life questionnaire, affected skin location, and skin color in the original scale. PMID:21747840

Kawakami, Tamihiro; Hashimoto, Takashi

2011-01-01

307

Correlation between HRCT and pulmonary functional tests in cystic fibrosis  

International Nuclear Information System (INIS)

Purpose. To compare the HRCT score by Oikonottlou and air trapping in expiratory scans with pulmonary functional tests and evaluate which radiological criteria are more useful to predict clinical impairment. Materials and methods. From January to September 2003, pulmonary HRCT study was performed in 37 patients (23 males), aged between 7 and 41 years, with cystic fibrosis. In the same day of CT examination they also received a complete functional evaluation. HRCT studies were evaluated by three radiologists blinded to the clinical data and were correlated with the lung function tests. Results. We obtained a high correlation (p=0.01) for two of the HRCT signs: extent of mucus plugging and mosaic perfusion pattern and all function tests. Discussion. Previous studies have demonstrated good correlation between lung function tests, in particular with FEV1 and HRCT signs. Our study differed from previous ones in that we analysed the correlation between lung function tests and with both single and combined CT criteria. Conclusion. Our results suggest that a simplified HRCT store could be useful to evaluate patients with cystic fibrosis

2005-10-01

308

Pre-validation of the WHO organ dysfunction based criteria for identification of maternal near miss  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background To evaluate the performance of the WHO criteria for defining maternal near miss and identifying deaths among cases of severe maternal morbidity (SMM admitted for intensive care. Method Between October 2002 and September 2007, 673 women with SMM were admitted, and among them 18 died. Variables used for the definition of maternal near miss according to WHO criteria and for the SOFA score were retrospectively evaluated. The identification of at least one of the WHO criteria in women who did not die defined the case as a near miss. Organ failure was evaluated through the maximum SOFA score above 2 for each one of the six components of the score, being considered the gold standard for the diagnosis of maternal near miss. The aggregated score (Total Maximum SOFA score was calculated using the worst result of the maximum SOFA score. Sensitivity, specificity, positive and negative predictive values of these WHO criteria for predicting maternal death and also for identifying cases of organ failure were estimated. Results The WHO criteria identified 194 cases of maternal near miss and all the 18 deaths. The most prevalent criteria among cases of maternal deaths were the use of vasoactive drug and the use of mechanical ventilation (?1 h. For the prediction of maternal deaths, sensitivity was 100% and specificity 70.4%. These criteria identified 119 of the 120 cases of organ failure by the maximum SOFA score (Sensitivity 99.2% among 194 case of maternal near miss (61.34%. There was disagreement in 76 cases, one organ failure without any WHO criteria and 75 cases with no failure but with WHO criteria. The Total Maximum SOFA score had a good performance (area under the curve of 0.897 for prediction of cases of maternal near miss according to the WHO criteria. Conclusions The WHO criteria for maternal near miss showed to be able to identify all cases of death and almost all cases of organ failure. Therefore they allow evaluation of the severity of the complication and consequently enable clinicians to build a plan of care or to provide an early transfer for appropriate reference centers.

Parpinelli Mary A

2011-08-01

309

Summary Variables in Observational Research: Propensity Scores and Disease Risk Scores.  

Science.gov (United States)

This paper describes the use of two types of summary scores in the context of observational research in pharmaco-epidemiology: propensity scores and disease risk scores. Either of these approaches collapses multiple potentially confounding variables into ...

J. D. Seeger P. G. Arbogast

2012-01-01

310

Combining Scores in Multiple-Criteria Assessment Systems: The Impact of Combination Rule  

Science.gov (United States)

Best practice in gifted and talented identification procedures involves making decisions on the basis of multiple measures. However, very little research has investigated the impact of different methods of combining multiple measures. This article examines the consequences of the conjunctive ("and"), disjunctive/complementary…

McBee, Matthew T.; Peters, Scott J.; Waterman, Craig

2014-01-01

311

Does Work Environment Affect Faculty Health Scores?  

Directory of Open Access Journals (Sweden)

Full Text Available This study investigates the relationship between self-reported health scores with work environment and various components of a women faculty score at a Research 1 University in the Midwest USA. The study examines the differences between male and female faculty responses in the various components making up the women faculty score and also gender differences in self-reported health scores and work environment scores. Differences between STEM and Non-STEM faculty are examined. A significant positive relationship is found between self-reported health scores and work environment controlling for gender. The study finds that the overall university work environment has a stronger relationship to faculty health than adequate gender ratio, women climate, and women leadership, even for women faculty. No significant differences in responses are found between STEM and Non-STEM faculty for women climate, women leadership, health scores, and work environment scores. Significant differences are found only in adequate gender ratio.

Rhonda C. Magel

2013-09-01

312

Locomotion problems of broiler chickens and its relationship with the gait score  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The objective of this study was to evaluate the correlation between the ability to walk (gait score), incidence of femoral degeneration, tibial dyschondroplasia, valgus and varus deformity and leg symmetry of broiler chickens. Male chickens of the Cobb strain from a commercial poultry farm were utilized in this experiment. Fifty 35 and 42-day-old birds were evaluated according to the gait score and valgus or varus incidence. To assess the bilateral symmetry and the lesion score for femoral de...

Barbara Cristina da Silva Fernandes; Márcia Regina Fernandes Boaro Martins; Ariel Antonio Mendes; Ibiara Correia de Lima Almeida Paz; Claudia Marie Komiyama; Elisane Lenita Milbradt; Bruna Boaro Martins

2012-01-01

313

Determining utility values in patients with anterior cruciate ligament tears using clinical scoring systems  

Digital Repository Infrastructure Vision for European Research (DRIVER)

BACKGROUND: Several instruments and clinical scoring systems have been established to evaluate patients with ligamentous knee injuries. A comparison of individual articles in the literature is challenging, not only because of heterogeneity in methodology, but also due to the variety of the scoring systems used to document clinical outcomes. There is limited information about the correlation between used scores and quality of life with no information being available on the impact of each s...

Farshad, M.; Gerber, C.; Szucs, T.; Meyer, D. C.

2011-01-01

314

ACR Appropriateness Criteria(®) myelopathy.  

Science.gov (United States)

Myelopathy is a problem that requires imaging to distinguish among numerous specifically treatable causes. The first priority is to determine mechanical stability after trauma. Next, it is crucial to distinguish intrinsic disease from extrinsic compression-for example, by epidural abscess. Osteophytes or disc extrusions and metastatic compression are the most common causes of extrinsic lesions. Imaging approaches rely on clinical features such as pain, fever, trauma, and pattern of progression. CT is preferred initially in acute trauma and MRI in all other circumstances. Contrast-enhanced MRI is added when tumor or infection is suspected or with slow or stepwise progression, especially when pain is not prominent. Vascular imaging is used when arteriovenous malformation, fistula, or occlusive disease is suspected. Because the treatment of myelopathy is often complex, treatment planning may require more than one imaging study or sequential examination to assess interval change. The ACR Appropriateness Criteria(®) are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances in which evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. PMID:22554628

Seidenwurm, David J; Wippold, Franz J; Cornelius, Rebecca S; Angevine, Peter D; Angtuaco, Edgardo J; Broderick, Daniel F; Brown, Douglas C; Davis, Patricia C; Garvin, Charles F; Hartl, Roger; Holly, Langston; McConnell, Charles T; Mechtler, Laszlo L; Smirniotopoulos, James G; Waxman, Alan D

2012-05-01

315

ACR Appropriateness Criteria Headache.  

Science.gov (United States)

Most patients presenting with uncomplicated, nontraumatic, primary headache do not require imaging. When history, physical, or neurologic examination elicits "red flags" or critical features of the headache, then further investigation with imaging may be warranted to exclude a secondary cause. Imaging procedures may be diagnostically useful for patients with headaches that are: associated with trauma; new, worse, or abrupt onset; thunderclap; radiating to the neck; due to trigeminal autonomic cephalgia; persistent and positional; and temporal in older individuals. Pregnant patients, immunocompromised individuals, cancer patients, and patients with papilledema or systemic illnesses, including hypercoagulable disorders may benefit from imaging. Unlike most headaches, those associated with cough, exertion, or sexual activity usually require neuroimaging with MRI of the brain with and without contrast to exclude potentially underlying pathology before a primary headache syndrome is diagnosed. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances in which evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. PMID:24933450

Douglas, Annette C; Wippold, Franz J; Broderick, Daniel F; Aiken, Ashley H; Amin-Hanjani, Sepideh; Brown, Douglas C; Corey, Amanda S; Germano, Isabelle M; Hadley, James A; Jagadeesan, Bharathi D; Jurgens, Jennifer S; Kennedy, Tabassum A; Mechtler, Laszlo L; Patel, Nandini D; Zipfel, Gregory J

2014-07-01

316

FHR Generic Design Criteria  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this document is to provide an initial, focused reference to the safety characteristics of and a licensing approach for Fluoride-Salt-Cooled High-Temperature Reactors (FHRs). The document does not contain details of particular reactor designs nor does it attempt to identify or classify either design basis or beyond design basis accidents. Further, this document is an initial attempt by a small set of subject matter experts to document the safety and licensing characteristics of FHRs for a larger audience. The document is intended to help in setting the safety and licensing research, development, and demonstration path forward. Input from a wider audience, further technical developments, and additional study will be required to develop a consensus position on the safety and licensing characteristics of FHRs. This document begins with a brief overview of the attributes of FHRs and then a general description of their anticipated safety performance. Following this, an overview of the US nuclear power plant approval process is provided that includes both test and power reactors, as well as the role of safety standards in the approval process. The document next describes a General Design Criteria (GDC)–based approach to licensing an FHR and provides an initial draft set of FHR GDCs. The document concludes with a description of a path forward toward developing an FHR safety standard that can support both a test and power reactor licensing process.

Flanagan, G.F.; Holcomb, D.E.; Cetiner, S.M.

2012-06-15

317

FHR Generic Design Criteria  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this document is to provide an initial, focused reference to the safety characteristics of and a licensing approach for Fluoride-Salt-Cooled High-Temperature Reactors (FHRs). The document does not contain details of particular reactor designs nor does it attempt to identify or classify either design basis or beyond design basis accidents. Further, this document is an initial attempt by a small set of subject matter experts to document the safety and licensing characteristics of FHRs for a larger audience. The document is intended to help in setting the safety and licensing research, development, and demonstration path forward. Input from a wider audience, further technical developments, and additional study will be required to develop a consensus position on the safety and licensing characteristics of FHRs. This document begins with a brief overview of the attributes of FHRs and then a general description of their anticipated safety performance. Following this, an overview of the US nuclear power plant approval process is provided that includes both test and power reactors, as well as the role of safety standards in the approval process. The document next describes a General Design Criteria (GDC) - based approach to licensing an FHR and provides an initial draft set of FHR GDCs. The document concludes with a description of a path forward toward developing an FHR safety standard that can support both a test and power reactor licensing process.

Flanagan, George F [ORNL; Holcomb, David Eugene [ORNL; Cetiner, Mustafa Sacit [ORNL

2012-06-01

318

Vestibular migraine : Diagnostic criteria  

DEFF Research Database (Denmark)

This paper presents diagnostic criteria for vestibular migraine, jointly formulated by the Committee for Classification of Vestibular Disorders of the Bárány Society and the Migraine Classification Subcommittee of the International Headache Society (IHS). The classification includes vestibular migraine and probable vestibular migraine. Vestibular migraine will appear in an appendix of the third edition of the International Classification of Headache Disorders (ICHD) as a first step for new entities, in accordance with the usual IHS procedures. Probable vestibular migraine may be included in a later version of the ICHD, when further evidence has been accumulated. The diagnosis of vestibular migraine is based on recurrent vestibular symptoms, a history of migraine, a temporal association between vestibular symptoms and migraine symptoms and exclusion of other causes of vestibular symptoms. Symptoms that qualify for a diagnosis of vestibular migraine include various types of vertigo as well as head motion-induced dizziness with nausea. Symptoms must be of moderate or severe intensity. Duration of acute episodes is limited to a window of between 5 minutes and 72 hours.

Lempert, Thomas; Olesen, Jes

2012-01-01

319

Axial spondyloarthritis criteria and modified NY criteria: issues and controversies.  

Science.gov (United States)

The Assessment of Spondyloarthritis International Society (ASAS) classification criteria for axial spondyloarthritis (axSpA) developed in 2009 was a major step forward, since the 1984 modified New York (mNY) criteria for classification of ankylosing spondylitis (AS) were too insensitive to identify patients with early signs of axial inflammation. In the absence of "diagnostic" criteria for either axSpA or AS, both of these "classification" criteria are routinely used in clinical practice to diagnose patients. However, there is a real danger of "misdiagnosis" if classification criteria are applied erroneously by ticking "yes" or "no" boxes in an undiagnosed patient. This concern was raised and discussed at the FDA Arthritis Advisory Committee meeting in June 2013, and the committee warned that if TNF inhibitors are approved to treat axSpA, such misdiagnosis could lead to serious consequences. To gauge the SPARTAN members' familiarity with these criteria and these issues surrounding them, as well as to investigate how they are using these criteria in daily practice, two questionnaires (one each for mNY and ASAS axSpA criteria) were sent to the "full" members of SPARTAN before the annual meeting. The results showed that more than 60 % of the responders used these criteria most of the time in practice to help them diagnose a patient, and nearly three fourth of responders agreed with the FDA Advisory Committee and would like to see some objective signs before prescribing TNF inhibitors to axSpA patients. A majority of responders looked at the sacroiliac joint x-rays themselves to diagnose sacroiliitis, even though they had difficulty in grading the x-rays. In a live vote at the meeting, 88 % of the members suggested that SPARTAN should engage in either modifying the existing criteria or develop new diagnostic criteria for axial spondyloarthritis. PMID:24838363

Deodhar, Atul

2014-06-01

320

Sibley Music Library: Musical Scores  

Science.gov (United States)

With over 10,000 digitized pieces of music in their online archive, the University of Rochester's Sibley Music Library is a force to be reckoned with for performers, musicologists, and others. The works in the archive come from the Eastman School of Music, and they are meant to be a performance resource, as well as a resource for those with a passion for music composition. Visitors can get started by looking over the "Musical Scores Recent Submissions" area near the top of the page. Here visitors can peruse romantic songs by G.W. Chadwick, a violin concerto by Carl von Reinecke, and a concert fantasy for piano and orchestra by Tchaikovsky. Also, visitors can use their search engine to look for favorite works and they can also subscribe to the RSS feed here.

 
 
 
 
321

Interpretation and Generalization of Score Matching  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Score matching is a recently developed parameter learning method that is particularly effective to complicated high dimensional density models with intractable partition functions. In this paper, we study two issues that have not been completely resolved for score matching. First, we provide a formal link between maximum likelihood and score matching. Our analysis shows that score matching finds model parameters that are more robust with noisy training data. Second, we devel...

Lyu, Siwei

2012-01-01

322

Interpretation of Quality-of-Life Scores  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Patients’ reports of their experience with illness are a key health outcome, but scores that measure these reports can be difficult to interpret. Skindex-29 measures skin-related quality of life reliably and validly. In this issue, Prinsen and colleagues compare patients’ responses to “anchor” questions with their Skindex scores to derive clinically meaningful scores for the subscales of Skindex-29. The cutoff scores identify patients whose skin diseases severely affect their quality ...

Chren, Mary-margaret

2010-01-01

323

Interpretation of Quality-of-Life Scores  

Science.gov (United States)

Patients’ reports of their experience with illness are a key health outcome, but scores that measure these reports can be difficult to interpret. Skindex-29 measures skin-related quality of life reliably and validly. In this issue, Prinsen and colleagues compare patients’ responses to “anchor” questions with their Skindex scores to derive clinically meaningful scores for the subscales of Skindex-29. The cutoff scores identify patients whose skin diseases severely affect their quality of life.

Chren, Mary-Margaret

2011-01-01

324

Automatic scoring of the severity of psoriasis scaling  

DEFF Research Database (Denmark)

In this work, a combined statistical and image analysis method to automatically evaluate the severity of scaling in psoriasis lesions is proposed. The method separates the different regions of the disease in the image and scores the degree of scaling based on the properties of these areas. The proposed method provides a solution to the lack of suitable methods to assess the lesion and to evaluate changes during the treatment. An experiment over a collection of psoriasis images is conducted to test the performance of the method. Results show that the obtained scores are highly correlated with scores made by doctors. This and the fact that the obtained measures are continuous indicate the proposed method is a suitable tool to evaluate the lesion and to track the evolution of dermatological diseases.

Gomez, David Delgado; Ersbøll, Bjarne Kjær

2004-01-01

325

Pretreatment Beck Depression Inventory score is an important predictor for Post-treatment score in infertile patients: a before-after study  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The experience of infertility can be extremely stressful. Some of the risk factors for depression in infertility are being female, repeated unsuccessful treatment cycles or a 2 to 3 year history of infertility, low socioeconomic status, foreign nationality, lack of partner support, life events and previous depression. In this study, we analyzed the Beck Depression Inventory score at the beginning and the end of infertility treatment, to determine which factors may influence the BDI score after treatment of infertility. Methods In a before-after study, in a university-affiliated teaching hospital, 251 women who had been visited for assisted reproductive technology infertility treatment participated in the study. BDI score was assessed before and after treatment of infertility. Results The mean BDI score rose after unsuccessful treatment and dropped after successful treatment. Those with lower education levels had a higher BDI score before treatment. BDI score after treatment was positively correlated with pretreatment BDI scoreand duration of infertility. Conclusion BDI score after treatment was strongly connected to the BDI score before treatment, the result of therapy and to the duration of infertility. The influence of duration of infertility on BDI score after treatment of infertility is weak. So a simple method to screen patients at risk of depression after infertility treatment is determining pretreatment BDI score and predicting the result of infertility treatment by other risk factors.

Ramezanzadeh Fatemeh

2005-05-01

326

Criteria for success | The NSMC  

...asd Criteria for success | The NSMC National Social Marketing Centre Contact Us on 020 7799 1900Shopping basket (empty) Member login / ...com Menu Home About us Services Resources Membership News What is social marketing? What is social marketing? Criteria for success Social marketing ...behavioural economics Social marketing FAQs Example projects Criteria for success The NSMC has reviewed behaviour change programmes to discover the secrets of success. ...of the following: Clear behavioural goals Customer orientation Theory Insight Exchange Competition Segmentation Methods mix These benchmark criteria are not just a ...

327

Fabrication criteria for shipping containers  

Energy Technology Data Exchange (ETDEWEB)

Criteria are identified for controlling the fabrication of metal components of shipping containers used for transporting radioactive materials. The criteria have been selected from the ASME Code and are based on the level of radioactive materials being transported and the nuclear safety function of the container's components. Criteria are identified for fabrication processes which are related to materials control, forming, heat treatment, examination and acceptance testing. Implementation of the criteria will ensure the structural integrity of shipping containers at levels consistent with the radioactive materials being transported. 14 references, 3 tables.

Fischer, L.E.; Lai, W.

1984-04-01

328

Rethinking Convenience Sampling: Defining Quality Criteria  

Directory of Open Access Journals (Sweden)

Full Text Available Convenience sampling is one of the most commonly used sampling procedures in second language acquisition studies, but this non-random sampling procedure suffers from a lot of problems including the inability of controlling for initial differences between experimental and control groups. The present study tries to introduce conditions and criteria which enable researchers to account for these drawbacks and at the same time make validity claims. Individual scores and group statistics are compared with regard to a group of essential factors known to be important for the purpose of the study. The overall value calculated for essential factors is then used to make judgments about the groups’ comparability. The contribution of this method to the current procedures of sampling arises from its factual accuracy which is supposed to enhance the validity of findings obtained from studies employing non-probability sampling procedures.

Asgar Mahmoudi-Hamidabad

2012-04-01

329

34 CFR 668.147 - Passing scores.  

Science.gov (United States)

...2009-07-01 2009-07-01 false Passing scores. 668.147 Section 668.147 Education...Administered Tests; Specification of Passing Score; Approval of State Process § 668.147 Passing scores. Except as provided in §§...

2009-07-01

330

Local Linear Observed-Score Equating  

Science.gov (United States)

Two methods of local linear observed-score equating for use with anchor-test and single-group designs are introduced. In an empirical study, the two methods were compared with the current traditional linear methods for observed-score equating. As a criterion, the bias in the equated scores relative to true equating based on Lord's (1980)…

Wiberg, Marie; van der Linden, Wim J.

2011-01-01

331

An analysis of electrocardiographic criteria for determining left ventricular hypertrophy  

Digital Repository Infrastructure Vision for European Research (DRIVER)

OBJECTIVE: To determine the most sensitive criterion for the detection of left ventricular hypertrophy according to echocardiographically defined left ventricular mass. METHODS: The Sokolow-Lyon voltage, Sokolow-Lyon-Rappaport, Cornell voltage duration product, White-Bock, and Romhilt-Estes point scoring criteria were compared with left ventricular mass index, corrected for body surface, obtained from the echocardiograms of 306 outpatients (176 females, 130 males), of all age groups. RESULTS:...

Gasperin Carlos Alberto; Germiniani Helio; Facin Carlos Roberto; Souza Admar Moraes de; Cunha Cláudio Leinig Pereira da

2002-01-01

332

ACR Appropriateness Criteria® Hemoptysis.  

Science.gov (United States)

Although hemoptysis is often self-limited and benign in origin, it can be an indicator of serious disease including bronchiectasis, granulomatous infection, and malignancy. Hemoptysis severity can be graded on the basis of the quantity of expectorated blood: hemoptysis as minor, 30 to 300 mL as moderate to severe (major), and >300 to 400 mL in 24 hours as massive. Among patients with hemoptysis, chest radiographs are often abnormal and can guide evaluation. The overall risk for malignancy in patients with normal radiographs is low but may be as much as 5% to 10% in patients with >30 mL of hemoptysis and those who are above 40 years of age and have significant smoking history. A combination of negative computed tomography and bronchoscopy results predicts a very low likelihood of lung malignancy diagnosis over medium-term follow-up (2 to 3 y). Bronchial and nonbronchial systemic arteries are much more frequent sources of hemoptysis than pulmonary arteries. Major or massive hemoptysis can usually be stopped acutely by bronchial arterial embolization. Recurrences, however, are common and often require repeat embolization. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances in which evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. PMID:24717602

Ketai, Loren H; Mohammed, Tan-Lucien H; Kirsch, Jacobo; Kanne, Jeffrey P; Chung, Jonathan H; Donnelly, Edwin F; Ginsburg, Mark E; Heitkamp, Darel E; Henry, Travis S; Kazerooni, Ella A; Lorenz, Jonathan M; McComb, Barbara L; Ravenel, James G; Saleh, Anthony G; Shah, Rakesh D; Steiner, Robert M; Suh, Robert D

2014-05-01

333

An Inmate Classification System Based on PCL: SV Factor Scores in a Sample of Prison Inmates  

Science.gov (United States)

Psychopaths represent a significant management challenge in a prison population. A sample of ninety-five male inmates from three medium security prisons was tested using the Hare Psychopathy Checklist: Screening Version (PCL:SV). Using traditional criteria, 22% of the inmates were classified as psychopaths. Scores on the two factor dimensions of…

Wogan, Michael; Mackenzie, Marci

2007-01-01

334

RELATIONSHIP BETWEEN FUNCTIONAL MOVEMENT SCREENING SCORE AND HISTORY OF INJURY  

Science.gov (United States)

Background and Aim: The Functional Movement Screen (FMS™) is a screening instrument that evaluates selective fundamental movement patterns. The main aim of this study was to investigate the relationship between the FMS™ score and history of injury, and attempt to determine which active students are prone to injury. Methods: One hundred physically active (50 females and 50 males) students, between 18 and 25 years of age, with no recent (<6 weeks) history of musculoskeletal injury were recruited. All participants performed the FMS™ and were scored using the previously established standardized FMS™ criteria. The chi square, independent t?test, one?way analysis of variance, and POSTHOC Bonferroni tests were used for data analysis with a preset alpha value of p < 0.05. Results: Of the 100 subjects, 35 suffered an acute lower extremity (ankle = 20, knee = 15) injury in practice or competition. An odds ratio was calculated at 4.70, meaning that an athlete had an approximately 4.7 times greater chance of suffering a lower extremity injury during a regular competitive season if they scored less than 17 on the FMS™. There were statistical differences between the pre?season FMS™ scores of the injured and non?injured groups, the ankle injury, knee injury, and non?injured groups, and also between contact injury, non?contact injury, and non?injured groups. Discussion and Conclusion: This cross?sectional study provides FMS™ reference values for physically active students, which will assist in the interpretation of individual scores when screening athletes for musculoskeletal injury and performance factors. More research is still necessary before implementing the FMS™ into a pre?participation physical examination (PPE) for athletics, but due to the low cost and its simplicity to implement, it should be considered by clinicians and researchers in the future. Level of Evidence: 2B

Hadadnezhad, Malihe; Shojaedin, Sadredin; Mohamadi, Elham

2014-01-01

335

Documentation of radiation-induced oral mucositis. Scoring Systems  

International Nuclear Information System (INIS)

Background: Radiation therapy of tumors in the head and neck region is frequently associated with severe side effects in the oral mucosa which often necessitate interruption of the prescribed treatment protocol. In order to compare therapeutic strategies and, more important, in order to perform multicenter studies, generally accepted scoring systems have to be applied for uniform documentation of the oral mucosal response. Methods: Different scoring protocols are found in the literature. The scoring protocols most widely accepted are the CTC classification and the RTOG/EORTC classification. These are compared with more detailed systems. Results: In the CTC classification, grading of stomatitis is included in the responses of the gastrointestinal tract and emphasizes dietary effects. For effects of radiation alone or of radiochemotherapy, the RTOG/EORTC system, focusing on therapeutic interventions, has been established. However, there are only minor differences in the grading of mucositis between these 2 protocols. Based on the RTOG/EORTC classification, Maciejewski et al. introduced a classification system with inclusion of the area affected, but also changed the sensitivity of the scores. The latter may be confusing if the source of the system used is not cited in a report. An alternative system was proposed by Dische, which in addition to objective morphologic criteria also includes the symptoms induced by the mucosal response, and hence includes some subjective aspects reported by the patient. Conclusions: For routine documentation of acute radiation side effects in the oral cavity, the German version of the RTOG/EORTC classification can be recommended. In studies with particular interest in oral mucositis, a more sensitive scoring system may be applied. In any publication concerning mucositis, a table or a detailed description of the system used should be included. (orig.)

1998-11-01

336

Design criteria and analysis methods for a CIRENE reactor core  

International Nuclear Information System (INIS)

This paper describes the design criteria and the analysis methods of a CIRENE reactor core. The design criteria are based on thermal-hydraulic considerations, and imply, in particular, a limitation of the Minimum Critical Power Ratio for the fuel channel. A survey is given in this paper of the validity of the adopted thermal-hydraulics correlations and the main neutronic and thermal-hydraulic calculation tools are illustrated, the accuracy and efficiency of which are also indicated

1976-01-01

337

Proposal of a CT scoring system of the paranasal sinuses in diagnosing cystic fibrosis  

International Nuclear Information System (INIS)

The purpose of this study was to develop a paranasal sinus CT scoring system that could be used as a diagnostic tool to discriminate cystic fibrosis (CF) patients from control patients examined for sinonasal disease. The model should include as few and easily applicable criteria as possible, supported by statistical analyses and clinical judgement. We used data from 116 CF and 136 control patients. The CF patients were grouped according to the number of confirmed CF mutations: genetically verified (CF-2), or based on sweat testing and clinical findings alone (CF-1, CF-0). Nine paranasal sinus CT criteria, including development, pneumatisation variants and inflammatory patterns, were evaluated. The final model included three criteria: (a) frontal and (b) sphenoid sinus development, and (c) absence of three pneumatisation variants. This model discriminated CF-2 from controls with overlap of summed scores in only 8 of 206 patients. When this model was applied in the CF-1 and CF-0 groups, two populations seemed to exist. A larger group with summed scores overlapping that of the CF-2 group and a smaller group with summed scores overlapping that of the control group. We conclude that this CT scoring system may support, as well as exclude, a CF diagnosis in cases of diagnostic uncertainty. (orig.)

2003-06-01

338

Tradução e validação do questionário FAOS - FOOT and ankle outcome score para língua portuguesa Translation, cultural adaptation and validation of FOOT and ankle outcome score (FAOS questionnaire into portuguese  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVOS: (1 traduzir e validar a versão original da avaliação funcional de tornozelo e pé Foot and Ankle Outcome Score (FAOS da língua inglesa para a portuguesa em pacientes com história de entorse de tornozelo em inversão, (2 adaptar culturalmente à população brasileira e (3 correlacionar com o questionário de qualidade de vida SF-36. MÉTODO: O método de tradução e validação utilizado seguiu os critérios descritos por Guillemin et al. Foram incluídos 50 indivíduos com diagnóstico clínico de lesão ligamentar lateral do tornozelo por entorse. RESULTADOS: O questionário FAOS mostrou-se com reprodutibilidade de grau forte para todos os domínios intra e inter-examinador (pOBJECTIVE: (1 to translate and validate the original version of the Foot and Ankle Outcome Score (FAOS questionnaire from English into Portuguese in patients with diagnosis of lateral ligament injuries with ankle sprain history,(2 to provide cultural adaptation for Brazilian patients (3 to correlate it with the quality of life SF_36 questionnaire. METHOD: The method of translation and validation followed the criteria described by Guillemin et al. Fifty patients with ankle sprain were included. RESULTS AND CONCLUSION: FAOS questionnaire showed good reproducibility for patients with ankle sprain and good reliability for all intraand inter-interviewer sub-scales (p<0.05. The translation and cultural adaptation of FAOS questionnaire had its properties of assessment, reliability and validity measured, showing that this questionnaire is suitable for use in Brazilian patients with lateral ligament ankle injuries.

Aline Mizusaki Imoto

2009-01-01

339

MHD-ETF design criteria  

Energy Technology Data Exchange (ETDEWEB)

This document establishes criteria to be utilized for the design of a pilot-scale (150 to 300 MW thermal) open cycle, coal-fired MHD/steam plant. Criteria for this Engineering Test Facility (ETF) are presented relative to plant siting, plant engineering and operations, MHD-ETF testing, costing and scheduling.

Retallick, F.D.

1978-04-01

340

Markovianity criteria for quantum evolution  

CERN Multimedia

We characterize a class of Markovian dynamics using the concept of divisible dynamical map. Moreover we provide a family of criteria which can distinguish Markovian and non-Markovian dynamics. These Markovianity criteria are based on a simple observation that Markovian dynamics implies monotonic behavior of several well known quantities like distinguishability of states, fidelity, relative entropy and genuine entanglement measures.

Chru?ci?ski, Dariusz

2012-01-01

 
 
 
 
341

Ambient Water Quality Criteria: Nitrosamines.  

Science.gov (United States)

Section 304(a) of the Clean Water Act (33 U.S.C. 1314(a)), requires EPA to publish and periodically update water quality criteria. These criteria are to reflect the latest scientific knowledge on the identifiable effects of pollutants on public health and...

1978-01-01

342

Total Mini-Mental State Examination score and regional cerebral blood flow using Z score imaging and automated ROI analysis software in subjects with memory impairment  

International Nuclear Information System (INIS)

The Mini-Mental State Examination (MMSE) is considered a useful supplementary method to diagnose dementia and evaluate the severity of cognitive disturbance. However, the region of the cerebrum that correlates with the MMSE score is not clear. Recently, a new method was developed to analyze regional cerebral blood flow (rCBF) using a Z score imaging system (eZIS). This system shows changes of rCBF when compared with a normal database. In addition, a three-dimensional stereotaxic region of interest (ROI) template (3DSRT), fully automated ROI analysis software was developed. The objective of this study was to investigate the correlation between rCBF changes and total MMSE score using these new methods. The association between total MMSE score and rCBF changes was investigated in 24 patients (mean age±standard deviation (SD) 71.5±9.2 years; 6 men and 18 women) with memory impairment using eZIS and 3DSRT. Step-wise multiple regression analysis was used for multivariate analysis, with the total MMSE score as the dependent variable and rCBF change in 24 areas as the independent variable. Total MMSE score was significantly correlated only with the reduction of left hippocampal perfusion but not with right (P<0.01). Total MMSE score is an important indicator of left hippocampal function. (author)

2008-07-01

343

Criteria for the diagnosis and severity stratification of acute pancreatitis  

Directory of Open Access Journals (Sweden)

Full Text Available Recent diagnostic and therapeutic progress for severe acute pancreatitis (SAP remarkably decreased the case-mortality rate. To further decrease the mortality rate of SAP, it is important to precisely evaluate the severity at an early stage, and initiate appropriate treatment as early as possible. Research Committee of Intractable Diseases of the Pancreas in Japan developed simpler criteria combining routinely available data with clinical signs. Severity can be evaluated by laboratory examinations or by clinical signs, reducing the defect values of the severity factors. Moreover, the severity criteria considered laboratory/clinical severity scores and contrast-enhanced computed tomography (CE-CT findings as independent risk factors. Thus, CE-CT scans are not necessarily required to evaluate the severity of acute pancreatitis. There was no fatal case in mild AP diagnosed by the CE-CT severity score, whereas case-mortality rate in those with SAP was 14.8%. Case-mortality of SAP that fulfilled the laboratory/clinical and the CE-CT severity criteria was 30.8%. It is recommended, therefore, to perform CE-CT examination to clarify the prognosis in those patients who were diagnosed as SAP by laboratory/clinical severity criteria. Because the mortality rate of these patients with SAP is high, such patients should be transferred to advanced medical units.

Kazuo Inui

2013-01-01

344

Development of the knowledge-based and empirical combined scoring algorithm (KECSA) to score protein-ligand interactions.  

Science.gov (United States)

We describe a novel knowledge-based protein-ligand scoring function that employs a new definition for the reference state, allowing us to relate a statistical potential to a Lennard-Jones (LJ) potential. In this way, the LJ potential parameters were generated from protein-ligand complex structural data contained in the Protein Databank (PDB). Forty-nine (49) types of atomic pairwise interactions were derived using this method, which we call the knowledge-based and empirical combined scoring algorithm (KECSA). Two validation benchmarks were introduced to test the performance of KECSA. The first validation benchmark included two test sets that address the training set and enthalpy/entropy of KECSA. The second validation benchmark suite included two large-scale and five small-scale test sets, to compare the reproducibility of KECSA, with respect to two empirical score functions previously developed in our laboratory (LISA and LISA+), as well as to other well-known scoring methods. Validation results illustrate that KECSA shows improved performance in all test sets when compared with other scoring methods, especially in its ability to minimize the root mean square error (RMSE). LISA and LISA+ displayed similar performance using the correlation coefficient and Kendall ? as the metric of quality for some of the small test sets. Further pathways for improvement are discussed for which would allow KECSA to be more sensitive to subtle changes in ligand structure. PMID:23560465

Zheng, Zheng; Merz, Kenneth M

2013-05-24

345

Comparison of Selvester QRS score with magnetic resonance imaging measured infarct size in patients with ST elevation myocardial infarction  

DEFF Research Database (Denmark)

Recent studies have shown that the Selvester QRS score is significantly correlated with delayed enhancement-magnetic resonance imaging (DE-MRI) measured myocardial infarct (MI) size in reperfused ST elevation MI (STEMI). This study further tests the hypothesis that Selvester QRS score correlates well with MI size determined by DE-MRI in reperfused STEMI.

Carlsen, Esben A; Bang, Lia E

2012-01-01

346

Prognóstico dos casos de pancreatite aguda pelo escore de PANC 3 / Prognosis of acute pancreatitis by PANC 3 score  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese RACIONAL: A pancreatite aguda é doença de grande importância na prática clínica, definida como inflamação do pâncreas podendo levar ao envolvimento de tecidos locais ou acometimento de outros órgãos de forma sistêmica, necessitando nesses casos de cuidados em terapia intensiva. OBJETIVO: Analisar o [...] sistema simplificado de estratificação de PANC 3, correlacionando-o com o escore de Ranson para definição prognóstica de casos de pancreatite aguda. MÉTODO: Foi realizado um estudo observacional, prospectivo em que foram avaliados 65 pacientes que foram diagnosticados com quadro de pancreatite aguda. RESULTADOS: Obteve para o PANC 3 sensibilidade de 31,25%; especificidade de 100%; valor preditivo positivo de 100%; valor preditivo negativo de 81,66% e acurácia de 83,07%. CONCLUSÕES: Os critérios de PANC 3 têm sua validade na definição de gravidade e prognóstico da pancreatite aguda, não como método substituto, mas como método a ser associado aos critérios de Ranson, principalmente pela sua alta acurácia, valor preditivo positivo e especificidade. Abstract in english BACKGROUND: Acute pancreatitis is a disease of great importance in clinical practice, defined as an inflammatory process of the pancreas that may involve local tissues or affect other organs in a systemic manner, requiring, in such cases, an intensive care. AIM: To analyze the simplified stratificat [...] ion system of the PANC 3 score, correlating it with the Ranson score, for the prognostic definition of cases of acute pancreatitis. METHOD: Was conducted a prospective, observational study in which were evaluated 65 patients who were diagnosed with acute pancreatitis. RESULTS: PANC 3 showed sensitivity, 31.25%; specificity,100%; positive predictive value, 100%; negative predictive value, 81.66% and accuracy, 83.07%. CONCLUSIONS: The PANC 3 criteria are applicable to define the severity and the prognosis of acute pancreatitis, and are not a substitute method, but rather a method to be associated with the Ranson criteria, mainly due to its high accuracy, positive predictive value and specificity.

James Ken, Fukuda; Orli, Franzon; Fernando de Oliveira, Resende-Filho; Nicolau Fernandes, Kruel; Thiago Alessandro, Ferri.

347

Relationship between motor performance and physical fitness score in 7- to 8-year-old children. DOI: 10.5007/1980-0037.2011v13n2p94  

Directory of Open Access Journals (Sweden)

Full Text Available There are many tests for the evaluation of motor performance or physical fitness that take into account different criteria such as movement forms and patterns, time, distance, and repetitions of each task for the analysis of performance. The aim of this study was to investigate the relationship between motor performance and physical fitness scores in children. Fifty children of both genders aged 7 to 8 years (25 boys and 25 girls participated in this study. The Test of Gross Motor Development – Second Edition (TGMD-2 was used for the evaluation of motor performance. Physical fitness was assessed by three specific tests proposed by the American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD. The results showed statistical significance and weak correlations among some skills such as run, horizontal jump, hop, leap, underhand roll, and medicine ball throw. The equivalent use of both tests may not be adequate since each test has its own peculiarities in terms of assessment criteria.

Patrik Felipe Nazario

2011-03-01

348

ACL reconstruction: a meta-analysis of functional scores.  

Science.gov (United States)

From individual randomized studies, it is unclear whether patellar tendon grafts or hamstring tendon grafts yield the best functional results after ACL reconstruction. Therefore, we performed a meta-analysis to provide quantitative data to compare patellar with hamstring grafts after ACL reconstruction with regard to knee function. We searched computerized databases for randomized controlled trials reporting one of the following outcomes related to function: final overall International Knee Documentation Committee score and return to preinjury level of activity. Studies were abstracted independently by two reviewers. Random effect models were used to pool the data. Fourteen trials (1263 patients) met the inclusion criteria. We found no difference in final overall International Knee Documentation Committee score or in the number of patients returning to full activity after patellar and hamstring graft reconstruction. Relative risk was 0.90 for final overall International Knee Documentation Committee Class A and 0.94 for return to preinjury level of activity in favor of patellar grafts. Quantitative interaction tests on the effect of treatment based on study quality, randomization status, number of strands used, and length of followup were non significant. At last followup, only 41% and 33% of patients, respectively, had patellar and hamstring grafts reconstructed reported as normal based on the final overall International Knee Documentation Committee score. PMID:17308473

Biau, David J; Tournoux, Caroline; Katsahian, Sandrine; Schranz, Peter; Nizard, Rémy

2007-05-01

349

MedusaScore: An Accurate Force-Field Based Scoring Function for Virtual Drug Screening  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Virtual screening is becoming an important tool for drug discovery. However, the application of virtual screening has been limited by the lack of accurate scoring functions. Here, we present a novel scoring function, MedusaScore, for evaluating protein-ligand binding. MedusaScore is based on models of physical interactions that include van der Waals, solvation and hydrogen bonding energies. To ensure the best transferability of the scoring function, we do not use any protein-ligand experiment...

Yin, Shuangye; Biedermannova, Lada; Vondrasek, Jiri; Dokholyan, Nikolay V.

2008-01-01

350

Cluster pair correlation function of simple fluids: energetic connectivity criteria  

CERN Document Server

We consider the clustering of Lennard-Jones particles by using an energetic connectivity criterion proposed long ago by T.L. Hill [J. Chem. Phys. 32, 617 (1955)] for the bond between pairs of particles. The criterion establishes that two particles are bonded (directly connected) if their relative kinetic energy is less than minus their relative potential energy. Thus, in general, it depends on the direction as well as on the magnitude of the velocities and positions of the particles. An integral equation for the pair connectedness function, proposed by two of the authors [Phys Rev. E 61, R6067 (2000)], is solved for this criterion and the results are compared with those obtained from molecular dynamics simulations and from a connectedness Percus-Yevick like integral equation for a velocity-averaged version of Hill's energetic criterion.

Pugnaloni, L A; Vericat, F; Pugnaloni, Luis A.; Zarragoicoechea, Guillermo J.; Vericat, Fernando

2006-01-01

351

Influence of scoring parameter settings on Agatston and volume scores for coronary calcification.  

Science.gov (United States)

Current multi-detector CT and electron beam tomography (EBT) technology enables the evaluation of coronary calcification. Multiple software packages are available to quantify calcification using several scoring algorithms implementing user-definable scoring parameters. We investigated the effect of scoring parameters on the calcium score outcome. Three parameters (four-connected or eight-connected, lesion size threshold and interpolation) are evaluated. Their theoretical influence on the scoring outcome is shown using simplified examples. To evaluate the effect in real data, we performed calcium scoring on randomly chosen EBT scans from 50 participants in an epidemiological study. Both the Agatston and volume scores were calculated. Changing from eight-connected to four-connected connectivity decreased both Agatston and volume scores (mean variability Agatston 3.15% and volume score -3.52%). Decreasing the threshold from 4 to 2 pixels increased the calcium scores because smaller lesions were also selected as calcified plaques (mean variability Agatston 16.23% and volume score 18.66%). Finally, the use of interpolation had a large negative effect on the volume score (mean variability -29.67%) and almost no effect on the Agatston score. Parameter settings in software for quantification for coronary calcification affect the calcium score outcome. Therefore, parameter settings for calcium scoring should be standardized. PMID:15372193

van Ooijen, Peter M A; Vliegenthart, Rozemarijn; Witteman, Jacqueline C M; Oudkerk, Matthijs

2005-01-01

352

Efficient entanglement criteria beyond Gaussian limits using Gaussian measurements  

CERN Document Server

We present a formalism to derive entanglement criteria beyond the Gaussian regime that can be readily tested by only homodyne detection. The measured observable is the Einstein-Podolsky-Rosen (EPR) correlation. Its arbitrary functional form enables us to detect non-Gaussian entanglement even when an entanglement test based on second-order moments fails. We illustrate the power of our experimentally friendly criteria for a broad class of non-Gaussian states under realistic conditions. We also show rigorously that quantum teleportation for continuous variables employs a specific functional form of EPR correlation.

Nha, Hyunchul; Ji, Se-Wan; Kim, M S

2012-01-01

353

GNS-12 Packaging design criteria  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this Packaging Design Criteria (PDC) is to provide criteria for the Safety Analysis Report for Packaging (SARP)(Onsite). The SARP provides the evaluation to demonstrate that the onsite transportation safety criteria are met for the transport and storage of the 324 Building vitrified encapsulated material in the GNS-12 cask. In this application, the approved PDC provides a formal set of standards for the payload requirements, and guidance for the current cask transport configuration and a revised storage seal and primary lid modification design.

Clements, E.P., Westinghouse Hanford

1996-07-24

354

Novel histologic scoring system for long-term allograft fibrosis after liver transplantation in children.  

Science.gov (United States)

The existing systems for scoring fibrosis were not developed to evaluate transplanted livers. Our aim was to design and validate a novel fibrosis scoring system specifically adapted to assess liver allograft fibrosis (LAF). Clinical data, histology, transient elastography (TE) and AST/platelet ratio index (APRI) were reviewed in 38 pediatric liver transplant (LT) recipients. Protocol liver biopsies performed at 6 months and 7 years post-LT were reviewed by three pathologists who assessed LAF using the METAVIR and Ishak systems. LAF was also scored separately in portal (0-3), sinusoidal (0-3) and centrolobular areas (0-3). Scoring evaluations were correlated with fibrosis quantification using morphometry, and also with TE and APRI. Statistical correlations between morphometry and METAVIR were 0.571 (p LAF than the existing scoring system and may become a practical tool for staging fibrosis in LT. PMID:22882699

Venturi, C; Sempoux, C; Bueno, J; Ferreres Pinas, J C; Bourdeaux, C; Abarca-Quinones, J; Rahier, J; Reding, R

2012-11-01

355

EVALUATION OF THE MODIFIED ALVARADO SCORE  

Directory of Open Access Journals (Sweden)

Full Text Available "nVarious scoring systems have been devised to aid diagnosis of acute appendicitis. The main objective of this study was finding the accuracy of modified Alvarado score in prediction of acute appendicitis. The registries of cases with appendectomy, who had been admitted to a referral medical center in the capital of Iran from February 2000 to March 2004, were studied. Sensitivity and specificity of modified Alvarado scoring and clinical diagnostic system used in our center were calculated. ROC curve analysis demonstrated increasing chance of acute appendicitis by increasing of the modified Alvarado score (P = 0.001, but it was neither sensitive nor specific (sensitivity, 55%; specificity, 59%. Diagnosis based on surgeons' decision was more sensitive than Alvarado scoring (sensitivity 93-95% in different age groups. Diagnosis of acute appendicitis based on surgeons' decision is more helpful than modified Alvarado score. "n 

R Yegane

2008-12-01

356

Scoring sacroiliac joints by magnetic resonance imaging. A multiple-reader reliability experiment.  

DEFF Research Database (Denmark)

Magnetic resonance imaging (MRI) of the sacroiliac (SI) joints and the spine is increasingly important in the assessment of inflammatory activity and structural damage in clinical trials with patients with ankylosing spondylitis (AS). We investigated inter-reader reliability and sensitivity to change of several scoring systems to assess disease activity and change in disease activity in patients with AS. Twenty sets of consecutive MRI, derived from a randomized clinical trial comparing an active drug with placebo and selected on the basis of the presence of activity at baseline, were presented electronically to 7 experienced readers from different countries (Europe, Canada). Readers scored the MRI by 3 different methods including: a global score (grading activity per SI joint); a more comprehensive global score (grading activity per SI joint per quadrant); and a detailed scoring system [Spondyloarthritis Research Consortium of Canada (SPARCC) scoring system], which scores 6 images, divided into quadrants, with additional scores for 'depth' and 'intensity.' A fourth and a fifth scoring system were constructed afterwards. The fourth method included the SPARCC score minus the additional scores for 'depth' and 'intensity,' and the fifth method included the SPARCC slice with the maximum score. Inter-reader reliability was investigated by calculating intraclass correlation coefficients (ICC) for all readers together and for all possible reader pairs. Sensitivity to change was investigated by calculating standardized response means (SRM) on change scores that were made positive. Overall inter-reader ICC per method were between 0.47 and 0.58 for scoring status, and between 0.40 and 0.53 for scoring change. ICC per possible reader pairs showed much more fluctuation per method, with lowest observed values close to zero (no agreement) and highest observed values over 0.80 (excellent agreement). In general, agreement of status scores was somewhat better than agreement of change scores, and agreement of the comprehensive SPARCC scoring system was somewhat better than agreement of the more condensed systems. Sensitivity to change differed per reader, but in general was somewhat better for the comprehensive SPARCC system. This experiment under 'real life,' far from optimal conditions demonstrates the feasibility of scoring exercises for method comparison, provides evidence for the reliability and sensitivity to change of scoring systems to be used in assessing activity of SI joints in clinical trials, and sets the conditions for further validation research in this field

Landewe, Robert B.M.; Hermann, Kay Geert A

2005-01-01

357

Score tests for heteroscedasticity: a new perspective  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In questo lavoro si ricavano delle diagnostiche bayesiane per l'eteroschedasticità dei residui in un modello di regressione multipla che risultano imperniate sulla funzione score alla base di molti score tests classici. Questo risultato apre una nuova prospettiva di indagine consistente nella ricerca delle condizioni sotto le quali le statistiche caratterizzanti gli score tests classici possono essere utilizzate piu' o meno direttamente in ambito bayesiano.

Carota, Cinzia

2002-01-01

358

Weight Trimming and Propensity Score Weighting  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Propensity score weighting is sensitive to model misspecification and outlying weights that can unduly influence results. The authors investigated whether trimming large weights downward can improve the performance of propensity score weighting and whether the benefits of trimming differ by propensity score estimation method. In a simulation study, the authors examined the performance of weight trimming following logistic regression, classification and regression trees (CART), boosted CART, a...

2011-01-01

359

EVALUATION OF THE MODIFIED ALVARADO SCORE  

Digital Repository Infrastructure Vision for European Research (DRIVER)

"nVarious scoring systems have been devised to aid diagnosis of acute appendicitis. The main objective of this study was finding the accuracy of modified Alvarado score in prediction of acute appendicitis. The registries of cases with appendectomy, who had been admitted to a referral medical center in the capital of Iran from February 2000 to March 2004, were studied. Sensitivity and specificity of modified Alvarado scoring and clinical diagnostic system used in our center were calculate...

Yegane, R.; Peyvandi, H.; Hajinasrollah, E.; Salehei, N.; Ahmadei, M.

2008-01-01

360

Shwachman-Kulczycki score still useful to monitor cystic fibrosis severity  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUCTION: The Shwachman-Kulczycki score was the first scoring system used in cystic fibrosis to assess disease severity. Despite its subjectivity, it is still widely used. OBJECTIVE: To study correlations among forced expiratory volume in one second (FEV1, chest radiography, chest computed tomography, 6-minute walk test, and Shwachman-Kulczycki score in patients with cystic fibrosis and to test whether the Shwachman-Kulczycki score is still useful in monitoring the severity of the disease. METHODS: A cross-sectional prospective study was performed to analyze the correlations (Spearman. Patients with clinically stable cystic fibrosis, aged 3-21 years, were included. RESULTS: 43 patients, 19F/24M, mean age 10.5 + 4.7 years, with a median Shwachman-Kulczycki score of 70 were studied. The median Brasfield and Bhalla scores were 17 and 10, respectively. The mean Z score for the 6-minute walk test was -1.1 + 1.106 and the mean FEV1 was 59 + 26 (as percentage of predicted values. The following significant correlations versus the Shwachman-Kulczycki score were found: FEV1 (r = 0.76, 6-minute walk test (r = 0.71, chest radiography (r = 0.71 and chest computed tomography (r = -0.78. When patients were divided according to FEV1, a statistically significantly correlation with the Shwachman-Kulczycki score was found only in patients with FEV1 <70% (r = 0.67. CONCLUSIONS: The Shwachman-Kulczycki score remains an useful tool for monitoring the severity of cystic fibrosis, adequately reflecting the functional impairment and chest radiography and tomography changes, especially in patients with greater impairment of lung function. When assessing patients with mild lung disease its limitations should be considered and its usefulness in such patients should be evaluated in larger populations.

Fabíola Stollar

2011-01-01