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1

Score Correlation.  

Czech Academy of Sciences Publication Activity Database

Ro?. 20, ?. 6 (2010), s. 793-798. ISSN 1210-0552 R&D Projects: GA ?R GA205/09/1079 Institutional research plan: CEZ:AV0Z10300504 Keywords : score function * correlation * rank correlation coefficient * heavy tails Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.511, year: 2010

Fabián, Zden?k

2010-01-01

2

Examining Classification Criteria: A Comparison of Three Cut Score Methods  

Science.gov (United States)

This study compared 3 different methods of creating cut scores for a screening instrument, T scores, receiver operating characteristic curve (ROC) analysis, and the Rasch rating scale method (RSM), for use with the Behavioral and Emotional Screening System (BESS) Teacher Rating Scale for Children and Adolescents (Kamphaus & Reynolds, 2007). Using…

DiStefano, Christine; Morgan, Grant

2011-01-01

3

The relationship between the ability to identify evaluation criteria and integrity test scores  

Directory of Open Access Journals (Sweden)

Full Text Available It has been argued that applicants who have the ability to identify what kind of behavior is evaluated positively in a personnel selection situation can use this information to adapt their behavior accordingly. Although this idea has been tested for assessment centers and structured interviews, it has not been studied with regard to integrity tests (or other personality tests. Therefore, this study tested whether candidates’ ability to identify evaluation criteria (ATIC correlates with their integrity test scores. Candidates were tested in an application training setting (N = 92. The results supported the idea that ATIC also plays an important role for integrity tests. New directions for future research are suggested based on this finding.

CORNELIUS J. KÖNIG

2006-09-01

4

Multi-criteria neutrosophic decision making method based on score and accuracy functions under neutrosophic environment  

OpenAIRE

A neutrosophic set is a more general platform, which can be used to present uncertainty, imprecise, incomplete and inconsistent. In this paper a score function and an accuracy function for single valued neutrosophic sets is firstly proposed to make the distinction between them. Then the idea is extended to interval neutrosophic sets. A multi-criteria decision making method based on the developed score-accuracy functions is established in which criterion values for alternativ...

S?ahin, R?dvan

2014-01-01

5

Analysis of four scoring systems and monocentric experience to optimize criteria for marginal kidneytransplantation.  

OpenAIRE

There is a strong need among the transplantation community to identify common criteria to utilize the pool of expanded criteria donors (ECD), considering the disparity between organ demand and supply as well as the benefits of transplantation on long-term mortality compared with survival on dialysis, also in patients transplanted with these organs. The purpose of this article was to analyze scoring systems proposed in literature by Nyberg, Anglicheau, Rao (Kidney Donor Risk Index), and Schold...

Segoloni, Giuseppe; Gallo, Ester; Tamagnone, Michela; Fop, Fabrizio

2010-01-01

6

Automatic Sleep Scoring in Normals and in Individuals with Neurodegenerative Disorders According to New International Sleep Scoring Criteria  

DEFF Research Database (Denmark)

The aim of this study was to develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine. A biomedical signal processing algorithm was developed, allowing for automatic sleep depth quantification of routine polysomnographic recordings through feature extraction, supervised probabilistic Bayesian classification, and heuristic rule-based smoothing. The performance of the algorithm was tested using 28 manually classified day-night polysomnograms from 18 normal subjects and 10 patients with Parkinson disease or multiple system atrophy. This led to quantification of automatic versus manual epoch-by-epoch agreement rates for both normals and abnormals. Resulting average agreement rates were 87.7% (Cohen's Kappa: 0.79) and 68.2% (Cohen's Kappa: 0.26) in the normal and abnormal group, respectively. Based on an observed reliability of the manual scorer of 92.5% (Cohen's Kappa: 0.87) in the normal group and 85.3% (Cohen's Kappa: 0.73) in the abnormal group, this study concluded that although the developed algorithm was capable of scoring normal sleep with an accuracy around the manual interscorer reliability, it failed in accurately scoring abnormal sleep as encountered for the Parkinson disease/multiple system atrophy patients.

Jensen, Peter S.; SØrensen, Helge Bjarup Dissing

2010-01-01

7

Automatic sleep scoring in normals and in individuals with neurodegenerative disorders according to new international sleep scoring criteria  

DEFF Research Database (Denmark)

Introduction: Reliable polysomnographic classification is the basis for evaluation of sleep disorders in neurological diseases. Aim: To develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine (AASM). Methods: A biomedical signal processing algorithm was developed, allowing for automatic sleep depth quantification of routine polysomnographic (PSG) recordings through feature extraction, supervised probabilistic Bayesian classification, and heuristic rule-based smoothing. The performance of the algorithm was tested using 28 manually classified day-night PSGs from 18 normal subjects and 10 patients with Parkinson's disease (PD) or multiple system atrophy (MSA). This led to quantification of automaticversus- manual epoch-by-epoch agreement rates for both normal and abnormal recordings. Results: Resulting average agreement rates were 87.7% (Cohen’s Kappa: 0.79) and 68.2%(Cohen’s Kappa: 0.26) in the normal and abnormal group, respectively. Based on an observed reliability of the manual scorer of 92.5% (Cohen’s Kappa: 0.87) in the normal group and 85.3% (Cohen’s Kappa: 0.73) in the abnormal group. Conclusion: The developed algorithm was capable of scoring normal sleep with an accuracy around the manual inter-scorer reliability, it failed in accurately scoring abnormal sleep as encountered for the PD/MSA patients, which is due to the abnormal micro- and macrostructure pattern in these patients.

Jensen, Peter S.; SØrensen, Helge Bjarup Dissing

2010-01-01

8

Criteria for genuine multiparticle quantum correlations  

International Nuclear Information System (INIS)

This thesis is devoted to different aspects of the detection and characterization of quantum correlations in multiparticle systems. These include the statistical verification of non-locality and entanglement in experiments, a versatile approach for the detection of genuine multipartite entanglement that will be applied to different classes of states and the characterization of entanglement using a multipartite hidden-variable theory. We start by investigating statistical effects on the confidence with which one can ensure that a multipartite state is non-local and therefore entangled. It turns out that for the standard photonic error model, the statistical significance of a non-locality test with comparably low violation, the so-called Mermin inequality, can exceed the significance of a test with high violation, namely of the Ardehali inequality. We also report about an experiment with four photons that verifies this behavior. Moreover, we also find that the range of white noise in which the Mermin inequality achieves a higher statistical significance grows exponentially with an increasing number of particles. Then, we pass on to the detection of genuine multipartite entanglement given the density matrix of a state. Using supersets of the sets of separable states, we introduce a criterion for genuine multipartite entanglement that can be implemented as a semidefinite program and test its performance on several example cases. Furthermore, this criterion naturally leads to an entanglement monotone that generalizes the bipartite negativity. Subsequently, the criterion is applied to the class of graph states. In this way, we obtain analytical construction methods for entanglement criteria, so-called entanglement witnesses, for many different graph states and an arbitrary number of qubits. These witnesses turn out to be strong, as their white noise tolerance converges to the maximum possible value, namely one, for a growing number of qubits. At the same time, the additional experimental effort in terms of settings to be measured, stays constant. Furthermore, as the criterion performs so well on graph states, we consider the question whether it can provide necessary and sufficient criteria for entanglement. We show that this is indeed the case for some special graph-diagonal states. In addition, our line of argument also provides deeper insights into the properties of our criterion and methods to construct biseparable graph-diagonal states. Finally, we turn to the characterization of quantum mechanical correlations given by the bipartite non-local model introduced by A. Leggett. We present different ways of extending this model to the case of many particles and also derive an inequality that shows the imcompatibility of such multipartite Leggett models with quantum mechanics. (author)

9

Pain threshold correlates with functional scores in osteoarthritis patients.  

Science.gov (United States)

Background and purpose - Pain sensitization may be one of the reasons for persistent pain after technically successful joint replacement. We analyzed how pain sensitization, as measured by quantitative sensory testing, relates preoperatively to joint function in patients with osteoarthritis (OA) scheduled for joint replacement. Patients and methods - We included 50 patients with knee OA and 49 with hip OA who were scheduled for joint replacement, and 15 control participants. Hip/knee scores, thermal and pressure detection, and pain thresholds were examined. Results - Median pressure pain thresholds were lower in patients than in control subjects: 4.0 (range: 0-10) vs. 7.8 (4-10) (p = 0.003) for the affected knee; 4.5 (2-10) vs. 6.8 (4-10) (p = 0.03) for the affected hip. Lower pressure pain threshold values were found at the affected joint in 26 of the 50 patients with knee OA and in 17 of the 49 patients with hip OA. The American Knee Society score 1 and 2, the Oxford knee score, and functional questionnaire of Hannover for osteoarthritis score correlated with the pressure pain thresholds in patients with knee OA. Also, Harris hip score and the functional questionnaire of Hannover for osteoarthritis score correlated with the cold detection threshold in patients with hip OA. Interpretation - Quantitative sensory testing appeared to identify patients with sensory changes indicative of mechanisms of central sensitization. These patients may require additional pain treatment in order to profit fully from surgery. There were correlations between the clinical scores and the level of sensitization. PMID:25323797

Kuni, Benita; Wang, Haili; Rickert, Markus; Ewerbeck, Volker; Schiltenwolf, Marcus

2015-04-01

10

Diffusion abnormality maps in demyelinating disease: Correlations with clinical scores  

International Nuclear Information System (INIS)

Background and purpose: Magnetic resonance imaging (MRI) has been explored as a noninvasive tool to assess pathology in multiple sclerosis (MS) patients. However, the correlation between classical MRI measures and physical disability is modest in MS. The diffusion tensor imaging (DTI) MRI technique holds particular promise in this regard. The present study shows brain regions where FA and individual diffusivities abnormalities are present and check their correlations with physical disability clinical scores. Methods: Eight patients and 12 matched healthy controls were recruited. The Multiple Sclerosis Functional Composite was administered. For MR-DTI acquisitions, a Genesis Signa 1.5T MR system, an EP/SE scanning sequence, 25 gradient directions were used. Results: Tract Based Spatial Statistics (TBSS) group comparisons showed reduced FA and increased individual diffusivities in several brain regions in patients. Significant correlations were found between FA and: EDSS, 9-HPT(NON)DOM and 25FW score; between ?2 and: P100 (r and l), 9-HPT(NON)DOM and 25FW; between ?3 and: 9-HPT(NON)DOM and 25FW score. Conclusions: Fractional anisotropy and individual radial diffusivities proved to be important markers of motor disabilities in MS patients when the disease duration mean and the disability scores values range are relatively high.

11

Internal consistency of scores on Matching Familiar Figures Test-20 and correlation of scores with age.  

Science.gov (United States)

Internal consistency of scores on the Matching Familiar Figures Test-20 and patterns of latencies and errors were estimated for 337 boys and 287 girls between the ages of 6 and 11 years, in the first five grades of primary school. The Matching Familiar Figures Test-20 presented moderate coefficients of internal consistency (.77) for errors and high coefficients (.94) for latencies. The correlation between latencies and errors was moderate and significant (-.50). PMID:9656271

Kirchner-Nebot, T; Amador-Campos, J A

1998-06-01

12

The Tower of London Test: different scoring criteria for diagnosing Alzheimer's disease and mild cognitive impairment.  

Science.gov (United States)

The Tower of London (TOL) is used for evaluating planning skills, which is a component of the executive functions. Different versions and scoring criteria were developed for this task, and some of them present with different psychometrical properties. This study aimed to evaluate two specific scoring methods of the TOL in diagnosing Mild Cognitive Impairment and probable Alzheimer's disease. The TOL total scores from 60 patients of each diagnosis were compared with the performance of 60 healthy-aged controls using receiver operating characteristics analysis and multinomial logistic regression. Krikorian method better diagnosed Alzheimer's disease, while Portellas's was better at discriminating healthy controls from Mild Cognitive Impairment, but were not efficient at comparing this last group with Alzheimer's patients. Regression analysis indicates that in addition to screening tests, TOL improves the classification of the three groups. The results suggest the two scoring methods used for this task may be useful for different diagnostic purposes. PMID:22662402

de Paula, Jonas Jardim; Moreira, Lafaiete; Nicolato, Rodrigo; de Marco, Luiz Armando; Côrrea, Humberto; Romano-Silva, Marco Aurélio; de Moraes, Edgar Nunes; Bicalho, Maria Aparecida; Malloy-Diniz, Leandro Fernandes

2012-04-01

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Diffuse Fatty Infiltration of the Liver: US Scoring System Correlated with CT and LFT  

International Nuclear Information System (INIS)

The present study was performed to estimate the accuracy of US examination in predicting the hepatic function in patients with diffuse fatty infiltration of the Liver. We compared the findings at US with the findings at CT and biochemical hepatic function test. US was performed by using 3.5MHz sector prove. We evaluated the US findings in terms or the degree of acoustic attenuation from the liver, the parenchymal echogenicity, the distinction of the portal vein wall, and the distinction of the diaphragm. Each parameter was graded into the numeric scores ranging from 0 to 2. The total US score was calculated from the scores of the four parameters. The total US score was compared with the difference in Hounsfield Units between the liver and spleen on nonenhanced CT images. The total US score was also compared with the aspartate(AST) and alanine transaminase(ALT) levels in peripheral blood. There was statistically significant correlation between the total US score and the difference in Hounsfield Unit between the liver and spleen on CT (r=0.7074, p<0.0001). When the total US score above 4 was considered as acriteria, the AST or ALT level were abnormal within the sensitivity of 90% and specificity of 60%. When the total US score above 5 was considered as a criteria, the sensitivity and specificity were 78% and 79%, respectively. In conclusion, US scoring system is useful in predicting the abnormal hepatic function in patients with diffuse fatty infiltration of the liver diffuse fatty infiltration of the liver

14

Metabolic syndrome criteria as predictors of subclinical atherosclerosis based on the coronary calcium score  

Science.gov (United States)

Background/Aims The aim was to determine which of three sets of metabolic syndrome (MetS) criteria (International Diabetes Federation [IDF], National Cholesterol Education Program Adult Treatment Panel III [ATP III], and European Group for the Study of Insulin Resistance [EGIR]) best predicts the coronary artery calcification (CAC) score in a cross-sectional study. This has not been evaluated in previous studies. Methods A total of 24,060 subjects were screened for CAC by multi-detector computed tomography. The presence of CAC was defined as a CAC score > 0. The odds ratio for the presence of CAC was analyzed for three different sets of MetS criteria and according to number of MetS components. Results CAC was observed in 12.6% (3,037) of the subjects. Patients with MetS, as defined by the IDF, ATP III, and EGIR criteria, had a CAC rate of 23.0%, 25.1%, and 29.5%, respectively (p < 0.001). Comparisons of C statistics for multivariate regression models revealed no significant difference among the three sets of criteria. After adjustment for risk factors, the ATP III criteria produced a slightly higher odds ratio for CAC compared with the other criteria, but this difference was not significant. The risk factor-adjusted odds ratio for the presence of CAC increased from 1 to 1.679 as the number of MetS components defined by ATP III increased from 0 to ? 3 (p for trend < 0.001). Conclusions The presence of MetS was associated with the presence of CAC. There was no significant difference among the three sets of MetS criteria in terms of the ability to predict CAC. An increase in the number of MetS components was associated with an increased odds of CAC. PMID:25589838

Seo, Mi Hae; Rhee, Eun-Jung; Park, Se Eun; Park, Cheol Young; Oh, Ki Won; Park, Sung Woo

2015-01-01

15

Spectrophotometric skin measurements correlate with EORTC/RTOG-common toxicity criteria  

International Nuclear Information System (INIS)

Purpose: it was investigated whether the elementary EORTC/RTOG-CTC score (Common Toxicity Criteria) for radiotherapy skin reactions correlates with spectrophotometric measurements of the skin color. Patients, material, and methods: in 41 patients irradiated for unilateral breast cancer the regular scoring by CTC was done during radiotherapy. In parallel, a total of 4,920 spectrophotometric measurements to determine the skin color were performed at baseline, at the beginning of radiotherapy, and at 20, 40 and 60 Gy. The nonirradiated contralateral breast was used for control measurements. Results: as expected, the skin color (especially red) depended on the radiation dose applied to the skin. The objective spectrophotometric measurements were found to correlate well with the subjective CTC scores. Conclusion: for classification of acute radiation toxicity there seems to be no need to replace the common CTC scoring by technical methods. (orig.)

16

Glasgow coma score and tumor necrosis factor ? as predictive criteria for initial poor graft function.  

Science.gov (United States)

Initial poor graft function (IPGF) is a major factor influencing the clinical outcome after liver transplantation (LT), but there is no reliable method to assess and predict graft dysfunction. To help clinicians determine prognosis in the early postoperative period, individual parameters and complex scoring systems have been suggested, but most of them are inaccurate because of the multifactorial nature of transplantation courses. Therefore, the aim of our study was to retrospectively evaluate predictive criteria for retransplantation. Forty-two patients were enrolled in this study: 18 who experienced primary non-function (PNF) and 24 with delayed graft function (DGF). All of the patients were treated with the Molecular Adsorbent Recirculating System (MARS). They were into 3 subgroups: patients who survived without LT (n = 20; 47.7%); patients who underwent LT (n = 16; 37%), and patients who died before transplantation (n = 6; 14%). Stepwise multivariable logistic regression analysis was performed with the intent to find the risk factors for LT or death after MARS treatment (second analysis). Receiver operating characteristic (ROC) curves were performed on significant variables in the logistic regression model with the intent to individually predict variables for LT or death. After a stepwise multivariable logistic regression analysis enrolling all of the previously reported features only 2 variables, tumor necrosis factor (TFN)-? and Glasgow coma score (GCS) score, were statistically significant. TNF-? was an unique independent risk factor for retransplantation or death after MARS treatment (odds ratio [OR] 1.235; P = .013). Conversely, GCS score was protective against retransplantation or death (OR 0.150; P = .003). Starting from these assumptions, a predictive model was created using these 2 variables. On ROC analysis, the combined score showed an area under the curve greater than that of the 2 variables considered separately. Validating these results with a larger number of patients, we considered these 2 factors as subjective parameters to determine outcomes and the difference between PNF and DGF. PMID:22974846

Novelli, G; Morabito, V; Lai, Q; Levi Sandri, G B; Melandro, F; Pugliese, F; Novelli, S; Rossi, M; Berloco, P B

2012-09-01

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Estimates of genetic parameters for visual scores and their correlation with production and reproductive traits in Brahman cattle  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The objective of this study was to evaluate the association of visual scores of body structure, precocity and muscularity with production (body weight at 18 months and average daily gain) and reproductive (scrotal circumference) traits in Brahman cattle in order to determine the possible use of thes [...] e scores as selection criteria to improve carcass quality. Covariance components were estimated by the restricted maximum likelihood method using an animal model that included contemporary group as fixed effect. A total of 1,116 observations of body structure, precocity and muscularity were used. Heritability was 0.39, 043 and 0.40 for body structure, precocity and muscularity, respectively. The genetic correlations were 0.79 between body structure and precocity, 0.87 between body structure and muscularity, and 0.91 between precocity and muscularity. The genetic correlations between visual scores and body weight at 18 months were positive (0.77, 0.57 and 0.59 for body structure, precocity and muscularity, respectively). Similar genetic correlations were observed between average daily gain and visual scores (0.60, 0.57 and 0.48, respectively), whereas the genetic correlations between scrotal circumference and these scores were low (0.13, 0.02, and 0.13). The results indicate that visual scores can be used as selection criteria in Brahman breeding programs. Favorable correlated responses should be seen in average daily gain and body weight at 18 months. However, no correlated response is expected for scrotal circumference.

Tássia Souza, Bertipaglia; Luis Orlando Duitama, Carreño; Carlos Henrique Cavallini, Machado; Cristiana, Andrighetto; Ricardo da, Fonseca.

1407-14-01

18

SCORE: a novel multi-criteria decision analysis approach to assessing the sustainability of contaminated land remediation.  

Science.gov (United States)

The multi-criteria decision analysis (MCDA) method provides for a comprehensive and transparent basis for performing sustainability assessments. Development of a relevant MCDA-method requires consideration of a number of key issues, e.g. (a) definition of assessment boundaries, (b) definition of performance scales, both temporal and spatial, (c) selection of relevant criteria (indicators) that facilitate a comprehensive sustainability assessment while avoiding double-counting of effects, and (d) handling of uncertainties. Adding to the complexity is the typically wide variety of inputs, including quantifications based on existing data, expert judgements, and opinions expressed in interviews. The SCORE (Sustainable Choice Of REmediation) MCDA-method was developed to provide a transparent assessment of the sustainability of possible remediation alternatives for contaminated sites relative to a reference alternative, considering key criteria in the economic, environmental, and social sustainability domains. The criteria were identified based on literature studies, interviews and focus-group meetings. SCORE combines a linear additive model to rank the alternatives with a non-compensatory approach to identify alternatives regarded as non-sustainable. The key strengths of the SCORE method are as follows: a framework that at its core is designed to be flexible and transparent; the possibility to integrate both quantitative and qualitative estimations on criteria; its ability, unlike other sustainability assessment tools used in industry and academia, to allow for the alteration of boundary conditions where necessary; the inclusion of a full uncertainty analysis of the results, using Monte Carlo simulation; and a structure that allows preferences and opinions of involved stakeholders to be openly integrated into the analysis. A major insight from practical application of SCORE is that its most important contribution may be that it initiates a process where criteria otherwise likely ignored are addressed and openly discussed between stakeholders. PMID:25594905

Rosén, Lars; Back, Pär-Erik; Söderqvist, Tore; Norrman, Jenny; Brinkhoff, Petra; Norberg, Tommy; Volchko, Yevheniya; Norin, Malin; Bergknut, Magnus; Döberl, Gernot

2015-04-01

19

Ultrafast CT scoring system for assessing bronchopulmonary dysplasia. Reproducibility and clinical correlation  

International Nuclear Information System (INIS)

To evaluate the reproducibility of the Ultrafast CT (UFCT) scoring system and assess its usefulness in monitoring clinical severity in infants with bronchopulmonary dysplasia (BPD). UFCT scoring was done in 22 infants (15 boys and 7 girls aged 1 to 37 months) with BPD. A total of 258 lung fields were evaluated for the presence of hyperaeration, linear opacities, triangular subpleural opacities, and bronchovascular bundle distortion or thickening, and UFCT scores were given. Intraobserver and interobserver agreement and reproducibility of UFCT scores were statistically analyzed. In 12 patients, UFCT scores were linearly correlated with clinical severity scores based on respiratory dysfunction and complexity of care. 'Hyperaeration,' which was the most frequent (18 of 22, 81.8%) finding, showed high concordance (?=0.73, p<0.001, ?=0.59, p<0.001), and its UFCT scores significantly correlated with intraobserver and interobserver analyses (r=0.94, p<0.001, r=0.82, p<0.001, respectively). UFCT scores for hyperaeration significantly correlated with clinical scores (r=0.75, p<0.01), whereas those for the others did not. UFCT is useful for assessing BPD. Hyperaeration was the most common and reproducible finding, and its extent significantly correlated with clinical severity. (author)

20

Ultrafast CT scoring system for assessing bronchopulmonary dysplasia. Reproducibility and clinical correlation  

Energy Technology Data Exchange (ETDEWEB)

To evaluate the reproducibility of the Ultrafast CT (UFCT) scoring system and assess its usefulness in monitoring clinical severity in infants with bronchopulmonary dysplasia (BPD). UFCT scoring was done in 22 infants (15 boys and 7 girls aged 1 to 37 months) with BPD. A total of 258 lung fields were evaluated for the presence of hyperaeration, linear opacities, triangular subpleural opacities, and bronchovascular bundle distortion or thickening, and UFCT scores were given. Intraobserver and interobserver agreement and reproducibility of UFCT scores were statistically analyzed. In 12 patients, UFCT scores were linearly correlated with clinical severity scores based on respiratory dysfunction and complexity of care. `Hyperaeration,` which was the most frequent (18 of 22, 81.8%) finding, showed high concordance ({kappa}=0.73, p<0.001, {kappa}=0.59, p<0.001), and its UFCT scores significantly correlated with intraobserver and interobserver analyses (r=0.94, p<0.001, r=0.82, p<0.001, respectively). UFCT scores for hyperaeration significantly correlated with clinical scores (r=0.75, p<0.01), whereas those for the others did not. UFCT is useful for assessing BPD. Hyperaeration was the most common and reproducible finding, and its extent significantly correlated with clinical severity. (author)

Kubota, Jun; Ohki, Yasushi; Inoue, Tomio; Mochizuki, Hiroyuki; Aoki, Jun; Morikawa, Akihiro; Endo, Keigo [Gunma Univ., Maebashi (Japan). School of Medicine; Sakurai, Minako; Shigeta, Makoto

1998-05-01

21

Automobile ride quality experiments correlated to iso-weighted criteria  

Science.gov (United States)

As part of an overall study to evaluate the usefulness of ride quality criteria for the design of improved ground transportation systems an experiment was conducted involving subjective and objective measurement of ride vibrations found in an automobile riding over roadways of various roughness. Correlation of the results led to some very significant relationships between passenger rating and ride accelerations. The latter were collapsed using a frequency-weighted root mean square measure of the random vibration. The results suggest the form of a design criterion giving the relationship between ride vibration and acceptable automobile ride quality. Further the ride criterion is expressed in terms that relate to rides with which most people are familiar. The design of the experiment, the ride vibration data acquisition, the concept of frequency weighting and the correlations found between subjective and objective measurements are presented.

Healey, A. J.; Young, R. K.; Smith, C. C.

1975-01-01

22

Correlation Study between WISC-III Scores and TOVA Performance.  

Science.gov (United States)

The Test of Variable Attention (TOVA), widely used in the assessment of Attention Deficit Hyperactivity Disorder, was studied along with the Wechsler Intelligence Scale for Children III (WISC-III). Explores whether the TOVA is a measure of psychomotor speed function rather than sustained attention. Results indicated that there was no correlation

Chae, Paul Kyuman

1999-01-01

23

The Influence of Prior Experience on the Construction of Scoring Criteria for ESL Compostions: A Case Study  

OpenAIRE

Before a principled explanation of variability in raters' judgements of ESL compositions can be offered, the process of constructing scoring criteria and the manner in which prior experience enters this process must be analyzed. Therefore, utilizing protocol and intewiew data collected in the context of a comparative study, a case study will describe how one experienced rater dealt with the following operations while assessing a corpus of 60 TOEFL essays: establishing the purpose of assessmen...

Usman Erdosy, M.

2001-01-01

24

Inflammation-based scores do not predict post-transplant recurrence of hepatocellular carcinoma in patients within Milan criteria.  

Science.gov (United States)

Increased preoperative inflammation scores, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and inflammation-based index (IBI) have been related to post-transplant HCC recurrence. We evaluated the association between inflammation-based scores (NLR, PLR, IBI) and post-LT HCC recurrence as well as tumor necrosis after transarterial embolization. 150 consecutive patients who underwent transplantation for HCC within the Milan criteria between 1996 and 2010 were included; data regarding inflammatory markers, patient and tumor characteristics were analyzed. NLR, PLR, and IBI were not significantly associated with post-LT HCC recurrence or worse overall survival. Increased NLR and PLR were associated with complete tumor necrosis in the subset of patients who received preoperative transarterial embolization (P < 0.05). Cox regression analysis revealed that absence of neoadjuvant transarterial therapy (OR = 4.33, 95% CI = 1.28-14.64; P = 0.02) and no fulfillment of the Milan criteria in the explanted liver (OR = 3.34, 95% CI = 1.08-10.35; P = 0.04) were independently associated with post-LT HCC recurrence inflammation-based scores did not predict HCC recurrence post-LT in our group of patients. NLR and PLR were associated with better response to TAE, as this was recorded histologically in the explanted liver. Histological fulfillment of the Milan criteria and absence of neoadjuvant transarterial treatment were significantly associated with post-LT HCC recurrence. PMID:25088400

Parisi, Ioanna; Tsochatzis, Emmanuel; Wijewantha, Hasitha; Rodríguez-Perálvarez, Manuel; De Luca, Laura; Manousou, Pinelopi; Fatourou, Evangelia; Pieri, Giulia; Papastergiou, Vassilios; Davies, Neil; Yu, Dominic; Luong, TuVinh; Dhillon, Amar Paul; Thorburn, Douglas; Patch, David; O'Beirne, James; Meyer, Tim; Burroughs, Andrew K

2014-11-01

25

HRCT score in bronchiectasis: Correlation with pulmonary function tests and pulmonary artery pressure  

Directory of Open Access Journals (Sweden)

Full Text Available Background: High resolution CT scan (HRCT and its score have an important role in delineating pathological changes and pulmonary functional impairment in patients with bronchiectasis. Aims: To assess pulmonary function tests (PFTs in patients with cystic and cylindrical bronchiectasis. To correlate HRCT score with PFTs and systolic pulmonary artery pressure (SPAP in both radiological types. Materials and Methods: A cross-sectional study of patients with bronchiectasis diagnosed by HRCT was conducted at King Khalid University Hospital, Riyadh, Saudi Arabia. PFTs, HRCT score and SPAP were measured in both types. Results: We studied 94 patients with bronchiectasis: 62 were cystic and 32 were cylindrical. Their mean age was 53.4±17.5 SD years. Forced vital capacity (FVC % and forced expiratory volume in 1 second (FEV1% were significantly lower in cystic patients ( P < .0001 compared with cylindrical and Diffusion capacity (DLCO % was also significantly lower ( p < 0.01. In cystic group PaO2 was significantly lower and PaCO2 higher ( P < 0.0001. HRCT score was correlated with FEV1% (r= -0.51. HRCT score was significantly lower in the cystic group ( P =0.002and correlated with SPAP ( r =0.23. Global HTCT score of 10.3±2.5 was associated with SPAP ?40mmHg( P =0.011. Conclusion: Patients with cystic bronchiectasis have significant impairment of pulmonary physiology compared with cylindrical bronchiectasis patients. HRCT score correlated with PFTs and SPAP.

Alzeer Abdulaziz

2008-01-01

26

High resolution CT in children with cystic fibrosis: correlation with pulmonary functions and radiographic scores  

Energy Technology Data Exchange (ETDEWEB)

Objective: To compare the high resolution CT (HRCT) scores of the Bhalla system with pulmonary function tests and radiographic and clinical points of the Shwachman-Kulczycki clinical scoring system. Methods: HRCT of the chest was obtained in 40 children to assess the role of HRCT in evaluating bronchopulmonary pathology in children with cystic fibrosis (CF). The HRCT severity scores of the Bhalla system were compared with chest radiographic and clinical points of the Shwachman-Kulczycki scoring system and pulmonary function tests. Only 14 of the patients older than 6 years cooperated with spirometry. Results: HRCT scores correlated well with radiographic points (r=0.80, P<0.0001) and clinical points (r=0.67, P<0.0001) of the Shwachman-Kulczycki system, FVC (r=0.71 P=0.004) and FEV{sub 1} (r=0.66, P=0.01). Although radiographic points correlated significantly with FVC (r=0.61, P=0.02) and FEV{sub 1} (r=0.56, P=0.04), HRCT provides a more precise scoring than the chest X-ray. Conclusion: The HRCT scoring system may provide a sensitive method of monitoring pulmonary disease status and may replace the radiographic scoring in the Shwachman-Kulczycki system. It may be helpful especially in follow-up of small children too young to cooperate with spirometry.

Demirkazik, Figen Basaran E-mail: demirkaz@dialup.ankara.edu.tr; Ariyuerek, O. Macit; Oezcelik, Ugur; Goecmen, Ayhan; Hassanabad, Hossein K.; Kiper, Nural

2001-01-01

27

High resolution CT in children with cystic fibrosis: correlation with pulmonary functions and radiographic scores  

International Nuclear Information System (INIS)

Objective: To compare the high resolution CT (HRCT) scores of the Bhalla system with pulmonary function tests and radiographic and clinical points of the Shwachman-Kulczycki clinical scoring system. Methods: HRCT of the chest was obtained in 40 children to assess the role of HRCT in evaluating bronchopulmonary pathology in children with cystic fibrosis (CF). The HRCT severity scores of the Bhalla system were compared with chest radiographic and clinical points of the Shwachman-Kulczycki scoring system and pulmonary function tests. Only 14 of the patients older than 6 years cooperated with spirometry. Results: HRCT scores correlated well with radiographic points (r=0.80, P1 (r=0.66, P=0.01). Although radiographic points correlated significantly with FVC (r=0.61, P=0.02) and FEV1 (r=0.56, P=0.04), HRCT provides a more precise scoring than the chest X-ray. Conclusion: The HRCT scoring system may provide a sensitive method of monitoring pulmonary disease status and may replace the radiographic scoring in the Shwachman-Kulczycki system. It may be helpful especially in follow-up of small children too young to cooperate with spirometry

28

Correlation of fracture index with BMD T score in postmenopausal females  

International Nuclear Information System (INIS)

Objective: To find the correlation between fracture index and BMD T-score so that fracture index can be used as a predictive tool for fracture risk estimation in post menopausal females. Design: A cross-sectional study was conducted on a sample of 396 women age 50 years and above. BMD T-score measurements using ultrasound and fracture index calculation based on the risk factor assessment were performed. Results: The study results showed that when fracture index increases BMD T-score decreased to osteoporotic range and correlation coefficient is -0.162. Conclusion: When fracture index increases, BMD T-score decreases therefore we can use fracture index as an assessment tool for predicting fracture risk in postmenopausal females. (author)

29

MR imaging of acute pancreatitis: Correlation of abdominal wall edema with severity scores  

International Nuclear Information System (INIS)

Objective: To study MRI findings of abdominal wall edema (AWE) in acute pancreatitis as well as correlations between AWE and the severity of acute pancreatitis according to the MR severity index (MRSI) and the Acute Physiology And Chronic Healthy Evaluation III (APACHE III) scoring system. Materials and methods: A total of 160 patients with AP admitted to our institution between December 2009 and March 2011 were included in this study. MRI was performed within 48 h after admission. MRI findings of acute pancreatitis were noted, including AWE on the MRI. The abdominal wall area was divided into quarters, and each area involved was recorded as 1 point to score the severity of AWE. The severity of acute pancreatitis was studied using both the MRSI and the APACHE III scoring system. Spearman correlation of AWE with the MRSI and the APACHE III scoring system was analyzed. Results: In 160 patients with acute pancreatitis, 53.8% had AWE on MRI. The average AWE score was 1.2 ± 1.4 points. The prevalence of AWE was 30.5%, 64.5% and 100% in mild, moderate and severe AP, respectively, according to MRSI. AWE on MRI was correlated with MRSI scores (r = 0.441, p = 0.000). According to APACHE III scores, the averages were 2.0 ± 1.1 and 2.6 ± 1.1 points in mild AP and severe AP, respectively (P = 0.016). AWE was slightly correlated with the APACHE III scores (r = 0.222, p = 0.005). Conclusion: AWE on MRI in acute pancreatitis is common, which may be a supplementary indicator in determining the severity of AP.

30

MR imaging of acute pancreatitis: Correlation of abdominal wall edema with severity scores  

Energy Technology Data Exchange (ETDEWEB)

Objective: To study MRI findings of abdominal wall edema (AWE) in acute pancreatitis as well as correlations between AWE and the severity of acute pancreatitis according to the MR severity index (MRSI) and the Acute Physiology And Chronic Healthy Evaluation III (APACHE III) scoring system. Materials and methods: A total of 160 patients with AP admitted to our institution between December 2009 and March 2011 were included in this study. MRI was performed within 48 h after admission. MRI findings of acute pancreatitis were noted, including AWE on the MRI. The abdominal wall area was divided into quarters, and each area involved was recorded as 1 point to score the severity of AWE. The severity of acute pancreatitis was studied using both the MRSI and the APACHE III scoring system. Spearman correlation of AWE with the MRSI and the APACHE III scoring system was analyzed. Results: In 160 patients with acute pancreatitis, 53.8% had AWE on MRI. The average AWE score was 1.2 {+-} 1.4 points. The prevalence of AWE was 30.5%, 64.5% and 100% in mild, moderate and severe AP, respectively, according to MRSI. AWE on MRI was correlated with MRSI scores (r = 0.441, p = 0.000). According to APACHE III scores, the averages were 2.0 {+-} 1.1 and 2.6 {+-} 1.1 points in mild AP and severe AP, respectively (P = 0.016). AWE was slightly correlated with the APACHE III scores (r = 0.222, p = 0.005). Conclusion: AWE on MRI in acute pancreatitis is common, which may be a supplementary indicator in determining the severity of AP.

Yang, Ru, E-mail: yangru0904@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Jing, Zong Lin, E-mail: jzl325@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Zhang, Xiao Ming, E-mail: zhangxm@nsmc.edu.cn [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Tang, Wei, E-mail: tw-n-g-up@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Xiao, Bo, E-mail: xiaoboimaging@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Huang, Xiao Hua, E-mail: nc_hxh1966@yahoo.com.cn [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Yang, Lin, E-mail: llinyangmd@163.com [Sichuan Key laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China); Feng, Zhi Song, E-mail: fengzhisong@medmail.com.cn [Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 (China)

2012-11-15

31

THE INFLUENCE OF PRIOR EXPERIENCE ON THE CONSTRUCTION OF SCORING CRITERIA FOR ESL COMPOSITIONS: A CASE STUDY  

Directory of Open Access Journals (Sweden)

Full Text Available Before a principled explanation of variability in raters' judgements of ESL compositions can be offered, the process of constructing scoring criteria and the manner in which prior experience enters this process must be analyzed. Therefore, utilizing protocol and intewiew data collected in the context of a comparative study, a case study will describe how one experienced rater dealt with the following operations while assessing a corpus of 60 TOEFL essays: establishing the purpose of assessment, developing a reading strategy to deal with a corpus of essays, and collecting context-specific information. Within each operation, the influence of background variables such as teaching and assessment experience will be examined, particularly on determining what type of information to collect, and on articulating expectations concerning test takers, test scores and the textual qualities of essays. The results of the study will be used to specific directions for future research into explaining inter-rater variability.

M. Usman Erdosy

2001-12-01

32

Admission Norton scale scores (ANSS) correlate with rehabilitation outcome and length in elderly patients with deconditioning.  

Science.gov (United States)

We sought to determine if admission Norton scale scores (ANSS) used for evaluating pressure ulcer risk also correlate with rehabilitation outcome and length in elderly patients with deconditioning. This was a retrospective study conducted in a geriatric department between June 2008 and June 2010. The medical charts of consecutive elderly (?65 years) patients admitted for rehabilitation due to deconditioning were studied for the following measurements: ANSS, admission albumin serum levels, mini-mental status examination (MMSE) scores, discharge walking functional independence measure (FIM) scores, discharge transfer FIM scores, and rehabilitation length. The cohort included 152 patients: 79 (52%) females and 73 (48%) males. Mean age was 83.6±6.5 years. The three most common causes of deconditioning were pneumonia, congestive heart failure exacerbation, and falls. ANSS correlated with discharge walking FIM scores (r=0.32; p=0.003), discharge transfer FIM scores (r=0.30; p=0.005), and length of rehabilitation (r=-0.37; prehabilitation length (pNorton scoring system may be used for predicting the outcome and the length of rehabilitation in elderly patients with deconditioning. PMID:21570133

Guy, Noam; Lerman, Yaffa; Justo, Dan

2012-01-01

33

New Perspectives on the Correlation of SAT Scores, High School Grades, and Socioeconomic Factors  

Science.gov (United States)

In studies of the SAT, correlations of SAT scores, high school grades, and socioeconomic factors (SES) are usually obtained using a university as the unit of analysis. This approach obscures an important structural aspect of the data: The high school grades received by a given institution come from a large number of high schools, all of which have…

Zwick, Rebecca; Greif Green, Jennifer

2007-01-01

34

Occupancy Rates and Emergency Department Work Index Scores Correlate with Leaving Without Being Seen  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: Two crowding metrics are often used to measure emergency department (ED crowding: the occupancy rate and the emergency department work index (EDWIN score. To evaluate these metrics for applicability in our community ED, we sought to measure their correlation with the number of patients who left without being seen (LWBS and determine if either, or both, correlated with our daily LWBS rate. We hypothesized a statistically significant positive correlation between the number of patients who LWBS and both crowding metrics.Methods: We performed a retrospective observational study by reviewing data on all patients who LWBS from December 1, 2007, to February 29, 2008. Occupancy rates and EDWIN scores were obtained through our electronic patient tracking board. We identified LWBS status by searching the final disposition entered into our electronic medical record. We measured the correlation between each crowding metric averaged over each 24-hour day and the number of patients who LWBS per 24-hour day using Spearman's rank correlation, and created receiver operator characteristic (ROC curves to quantify the discriminatory power of occupancy rate and EDWIN score for predicting more than two patients per day who LWBS.Results: We identified 1,193 patients who LWBS during the study period, including patients who registered but then left the waiting room (733, as well as those who left before: registration (71, triage (75, seeing a physician (260, or final disposition (54. The number of patients who LWBS per day ranged from one to 30, with a mean of 13 and median of 11 (IQR 6 to 19. The daily number of patients who LWBS showed a positive correlation with the average daily occupancy rate (Spearman’s rho = 0.771, p = 0.01 and with average daily EDWIN score (Spearman's rho = 0.67, p< .001. Area under the ROC curve for occupancy rate was .97 (95% CI .93 to 1.0 and for EDWIN score was .94 (95% CI .89 to 1.0.Conclusion: Average daily occupancy rates and EDWIN scores both correlate positively with, and have excellent discriminatory power for, the number of patients who LWBS in our ED; however, the scale of our EDWIN scores differs from that obtained at other institutions. For studies of crowding, occupancy rate may be the more useful metric due to its ease of calculation. [West J Emerg Med. 2010; 11(4:324-328.

Kulstad, Erik B

2010-09-01

35

Correlated Criteria in Decision Models: Recurrent Application of TOPSIS Method  

OpenAIRE

The purpose of multicriteria decision models is to help decision maker to evaluate each alternative and to rank them in descending order of performance. A problem can appear when the criteria are not independent. This study explores the effect of multicollinearity between criteria in decision making with the technique for order preference by similarity to ideal solution (TOPSIS) and proposes an algorithm to resolve this problem. The algorithm was based on the application of the TOPSIS method ...

Bondor, Cosmina Ioana; Mures?an, Adriana

2012-01-01

36

MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage  

DEFF Research Database (Denmark)

INTRODUCTION: The aim of this study was to investigate the magnetic resonance imaging (MRI) features of bone disease in the arthritis mutilans (AM) form of psoriatic arthritis (PsA). METHODS: Twenty-eight patients with erosive PsA were enrolled (median disease duration of 14 years). Using x-rays of both hands and feet, 11 patients were classified as AM and 17 as non-AM (erosive psoriatic arthritis without bone lysis)by two observers. MRI scans (1.5T) of the dominant hand (wrist and fingers scanned separately) were obtained using standard contrast-enhanced T1-weighted and fat-saturated T2-weighted sequences. Scans were scored separately by two readers for bone erosion, oedema and proliferation using a PsA MRI scoring system. X-rays were scored for erosions and joint space narrowing. RESULTS: On MRI, 1013 bones were scored by both readers. Reliability for scoring erosions and bone oedema was high (intraclass correlation coefficients = 0.80 and 0.77 respectively) but only fair for bone proliferation (intraclass correlation coefficient = 0.42). MRI erosion scores were higher in AM patients (53.0 versus 15.0, p = 0.004) as were bone oedema and proliferation scores (14.7 versus 10.0, p = 0.056 and 3.6 versus 0.7, p = 0.003 respectively). MRI bone oedema scores correlated with MRI erosion scores and X-ray erosion and joint space narrowing scores (r = 0.65, p = 0.0002 for all) but not the disease activity score 28-C reactive protein (DAS28CRP) or pain scores. CONCLUSIONS: In this patient group with PsA, MRI bone oedema, erosion and proliferation were all more severe in the AM-form. Bone oedema scores did not correlate with disease activity measures but were closely associated with X-ray joint damage scores. These results suggest that MRI bone oedema may be a pre-erosive feature and that bone damage may not be coupled with joint inflammation in PsA.

Tan, Yu M; Østergaard, Mikkel

2009-01-01

37

Do hospital-acquired condition scores correlate with patients' perspectives of care?  

Science.gov (United States)

Beginning in fiscal year 2015, the federal Hospital-Acquired Condition (HAC) Reduction Program requires the Centers for Medicare & Medicaid Services to reduce payments by 1% for hospitals in the top quartile of risk-adjusted national HAC scores. The HAC penalty underscores the need for hospitals to become increasingly quality- and safety-focused, which could negatively affect their performance on patient satisfaction with care, another key performance metric tied to reimbursement. Using publicly available data through the Centers for Medicare & Medicaid Services Hospital Compare program, we assessed the correlation between preliminary HAC scores and patients' perspectives of care, as measured by the Hospital Consumer Assessment of Healthcare Providers and Systems survey. Higher quality of care (lower HAC score) was modestly associated with a better patient experience (r = -0.090, P trade-off between delivering high quality of care and patient satisfaction. PMID:25830614

Menendez, Mariano E; Ring, David

2015-01-01

38

Massa ventricular e critérios eletrocardiográficos de hipertrofia: avaliação de um novo escore Ventricular mass and electrocardiographic criteria of hypertrophy: evaluation of new score  

Directory of Open Access Journals (Sweden)

Full Text Available FUNDAMENTO: A hipertrofia ventricular esquerda (HVE é um importante e independente fator de risco cardiovascular. Inexistem, no Brasil, estudos desenhados para testar a eficácia do eletrocardiograma (ECG no diagnóstico desse grave processo patológico. OBJETIVO: Avaliar um novo escore eletrocardiográfico para diagnóstico de HVE pelo ECG: soma da maior amplitude da onda S com a maior da onda R no plano horizontal, multiplicando-se o resultado pela duração do QRS [(S+R X QRS] e comparando-o com os critérios eletrocardiográficos clássicos. MÉTODOS: Foram analisados os ecocardiogramas e ECG de 1.204 pacientes hipertensos em tratamento ambulatorial. Avaliou-se o índice de massa do ventrículo esquerdo (IMVE pelo ecocardiograma, firmando-se o diagnóstico de HVE quando > 96 g/m² para mulheres e > 116 g/m² para homens. No ECG analisaram-se quatro critérios clássicos de HVE, além do novo escore a ser testado. RESULTADOS: Todos os índices estudados tiveram correlação estatisticamente significativa com a massa calculada do ventrículo esquerdo (VE. Porém, o novo escore foi o que apresentou maior correlação (r = 0,564. Os outros critérios apresentaram as seguintes correlações: Romhilt-Estes (r = 0,464; Sokolow-Lyon (r = 0,419; Cornell voltagem (r = 0,377; Cornell duração (r = 0,444. Para avaliação da acurácia do índice testado, utilizou-se o ponto de corte de 2,80 mm.s. Com esse valor foram obtidas as seguintes cifras para sensibilidade e especificidade: 35,2% e 88,7%, respectivamente. CONCLUSÃO: Todos os critérios eletrocardiográficos para avaliação da massa do VE apresentaram baixa sensibilidade. O novo escore foi o que apresentou melhor correlação com o IMVE em relação aos outros avaliados.BACKGROUND: The left ventricular hypertrophy (LVH is an important and independent cardiovascular risk factor. There is a scarcity of studies in Brazil designed to test the efficacy of the electrocardiogram (ECG in the diagnosis of this important pathological process. OBJECTIVE: To evaluate a new electrocardiographic score for the diagnosis of LVH by ECG: the sum of the highest amplitude of the S wave and the highest amplitude of the R wave on the horizontal plane, multiplied by the result of the QRS duration [(S+R X QRS] and comparing it with the classic electrocardiographic criteria. METHODS: The echocardiograms and ECG of 1,204 hypertensive patients receiving outpatient care were evaluated. The left ventricular mass index (LVMI was assessed by the echocardiogram, with a diagnosis of LVH when the LVMI was > 96 g/m² for women and > 116 g/m² for men. Four classic criteria of LVH were analyzed at the ECG, in addition to the new score to be tested. RESULTS: In general, the studied ECG-LVH criteria showed significant statistical correlation to the echocardiographic LVMI. The (R+S X QRS index, using 2.80 mm.s as the cutoff value, provided test accuracy regarding sensibility and specificity of 35.2% and 88.71%, respectively, representing the best correlation to LVMI (r=0.564 when compared to the other indexes: Romhilt-Estes (r=0.464; Sokolow-Lyon (r=0.419; Cornell voltage (r=0.377; Cornell product r=0.444. CONCLUSION: All the electrocardiographic criteria used for the assessment of the LV mass presented low sensitivity. The new score presented the best correlation with LVMI when compared to the other indexes.

Cléber do Lago Mazzaro

2008-04-01

39

Correlation between microsatellite discrepancy scores and transplant outcome after haemopoietic SCT for pediatric ALL.  

Science.gov (United States)

Microsatellite analyses show that self-reported ethnicity often correlates poorly with true genetic ancestry. As unknown ancestral differences could potentially have an impact on transplant outcome, we developed an average allele length discrepancy (AALD) score to assess allele length discrepancy between donor/recipient (D/R) using microsatellites analysed routinely in post-transplant chimeric assessment. This was then compared with outcome in a homogeneously treated cohort of pediatric patients undergoing high-resolution sibling or matched unrelated donor transplantation for acute lymphoblastic leukemia (ALL). AALD scores formed a numeric continuum ranging from 0 to 1.4 (median 0.76) for sibling pairs and 0.8-2.17 (median 1.6) for high-resolution matched unrelated donor (HR-MUD) pairs. There was a trend for worse OS with increasing AALD score, which reached statistical significance above a threshold of 1.7 for OS. Patients whose transplants had an AALD score of ?1.8 had a risk of non-relapse mortality 4.9 times greater (P=0.025) and relapse risk three times greater (P=0.058) than those scoring <1.8. This approach will now be explored in a Centre International for Blood and Marrow Transplantation Research (CIBMTR) study of 750 D/R pairs across all disease groups; if confirmed, it has the potential to improve donor selection for patients with multiple prospective donors. PMID:25581412

Harvey, J; Green, A; Groves, S J; Cornish, J; Moppett, J; Cummins, M; Keen, L; Culliford, S; Poles, A; Hulme, W; Li, Y; Steward, C G

2015-03-01

40

Correlation criteria for Bell type inequalities and entanglement detection  

CERN Document Server

We provide a novel criterion for identifying quantum correlation, which allows us to find connections between Bell type inequalities, entanglement detection, and correlation. We utilize the criterion to construct witness operators that can detect genuine multi-qubit entanglement with fewer local measurements. The connection between identifications of quantum correlation and Mermin's inequality is discussed. Detection of genuine four-level tripartite entanglement with two local measurement settings is shown in the same manner. Further, through the criterion of quantum correlation, we derive a new Bell inequality for arbitrary high-dimensional bipartite systems, which requires fewer analyses of the measured outcomes.

Li, C M; Chen, Y N; Chuu, D S; Hsu, L Y; Lin, W Y; Brandes, Tobias; Chen, Yueh-Nan; Chuu, Der-San; Hsu, Li-Yi; Li, Che-Ming; Lin, Wei-Yang

2006-01-01

41

Defining optimal cutoff scores for cognitive impairment using Movement Disorder Society Task Force criteria for mild cognitive impairment in Parkinson's disease.  

Science.gov (United States)

The recently proposed Movement Disorder Society (MDS) Task Force diagnostic criteria for mild cognitive impairment in Parkinson's disease (PD-MCI) represent a first step toward a uniform definition of PD-MCI across multiple clinical and research settings. However, several questions regarding specific criteria remain unanswered, including optimal cutoff scores by which to define impairment on neuropsychological tests. Seventy-six non-demented PD patients underwent comprehensive neuropsychological assessment and were classified as PD-MCI or PD with normal cognition (PD-NC). The concordance of PD-MCI diagnosis by MDS Task Force Level II criteria (comprehensive assessment), using a range of standard deviation (SD) cutoff scores, was compared with our consensus diagnosis of PD-MCI or PD-NC. Sensitivity, specificity, and positive and negative predictive values were examined for each cutoff score. PD-MCI subtype classification and distribution of cognitive domains impaired were evaluated. Concordance for PD-MCI diagnosis was greatest for defining impairment on neuropsychological tests using a 2 SD cutoff score below appropriate norms. This cutoff also provided the best discriminatory properties for separating PD-MCI from PD-NC compared with other cutoff scores. With the MDS PD-MCI criteria, multiple domain impairment was more frequent than single domain impairment, with predominant executive function, memory, and visuospatial function deficits. Application of the MDS Task Force PD-MCI Level II diagnostic criteria demonstrates good sensitivity and specificity at a 2 SD cutoff score. The predominance of multiple domain impairment in PD-MCI with the Level II criteria suggests not only influences of testing abnormality requirements, but also the widespread nature of cognitive deficits within PD-MCI. PMID:24123267

Goldman, Jennifer G; Holden, Samantha; Bernard, Bryan; Ouyang, Bichun; Goetz, Christopher G; Stebbins, Glenn T

2013-12-01

42

Evaluation of cytogenetic damage in workers exposed to microwave radiation of GEM radar using new criteria in scoring micronucleus test  

International Nuclear Information System (INIS)

The cytokinesis-block micronucleus assay is one of the standard cytogenetic tools employed in the assessment of chromosomal damage subsequent to the exposure to genotoxic/cytotoxic agents on human cells. Within the frame of this study, the cytokinesis-block micronucleus assay was used to assess the baseline cytogenetic damage in binuclear lymphocytes in workers occupationally exposed to microwave radiation of GEM radar by virtue of measuring the frequency of micronuclei, nucleoplasmic bridges and nuclear buds. Microwave radiation of GEM radar equipment acts within microwave field of 10 ?W/cm2 to 10 mW/cm2 and frequency range of 1.5 GHz to 10.9 GHz that has contradictory cytogenetic effect on human cells and DNA molecule. For that reason we used new criteria in scoring micronucleus assay that allows us to measure nucleoplasmic bridges and nuclear buds in addition to micronucleus frequency for more accurate effect on possible damage on the level of the cells. Parameters of the micronucleus test were studied in workers occupationally exposed to microwave radiation of GEM radar and in corresponding unexposed control subjects. It was found that in the subjects who were occupationally exposed to microwave radiation, the levels of micronuclei increased and showed interindividual variations. In addition, new parameters that were measured; nucleoplasmic bridges and nuclear buds, were detected in exposed group in compare to control group that did not showompare to control group that did not shown this type of damage. Differences between mean group values were statistically significant (P<0.05). Our study indicates that micronucleus assay is a very useful tool in the assessment of cytogenetic damage of individuals exposed to microwave radiation of GEM radar equipment. On the basis of the micronucleus frequency and frequencies of nucleoplasmic bridges and nuclear buds, the micronucleus technique with an easy and short-term application and with an easy scoring can be used for detection of damage induced by this type of radiation. (author)

43

Correlation between semiquantitative myocardial perfusion score and absolute myocardial flow in 13N-ammonia PET  

International Nuclear Information System (INIS)

13N-ammonia is a well known radiopharmaceutical for the measurement of a myocardial blood flow (MBF) non-invasively using PET-CT. In this study, we investigated a correlation between MBF obtained from dynamic imaging and myocardial perfusion score (MPS) obtained from static imaging for usefulness of cardiac PET study. Twelve patients (11 males, 1 female, 57.9 ± 8.6 years old) with suspicious coronary artery disease underwent PET-CT scan. Dynamic scans (6 min: 5 sec X 12, 10 sec X 6, 20 sec X 3, and 30 sec X 6) were initiated simultaneously with bolus injection of 11 MBq/kg 13N-ammonia to acquire rest and stress image. Gating image was acquired during 13 minutes continuously. Nine-segment model (4 basal walls, 4 mid walls, and apex) was used for a measurement of MBF. Time activity curve of input function and myocardium was extracted from ROI methods in 9 regions for quantification. The MPS were evaluated using quantitative analysis software. To compare between 20-segment model and 9-segment model, 6 basal segments were excluded and averaged segmental scores were used. There are weak correlation between MBF (rest, 0.18-2.38 ml/min/g; stress, 0.40-4.95 ml/min/g) and MPS (rest 22-91%, stress, 14-90%), however the correlation coefficient between corrected MBF and MPS in rest state was higher than stress state (rest r=0.59; stress r=0.80). As a thickening increased, correlation between MBF and MPS also showed good correlation at each segments. Correctood correlation at each segments. Corrected and translated MPS as its characteristics using 13N-ammonia showed good correlation with absolute MBF measured by dynamic image in this study. Therefore, we showed MPS is one of good indices which reflect MBF. We anticipate PET-CT could be used as useful tool for evaluation of myocardial function in nuclear cardiac study

44

A membrane TNF-alpha/TNFR ratio correlates to MODS score and mortality.  

Science.gov (United States)

This study hypothesizes that post-trauma elevated membrane-associated tumor necrosis factor-alpha (mTNF) and decreased TNF receptor shedding may be more related to development of multiple organ dysfunction syndrome (MODS) than elevated secreted TNF-alpha. We also address several of the possible reasons for the previous conflicting reports in studies correlating trauma patients sera TNF-alpha levels to their clinical outcome. These are 1) the lack of an objective quantitative score of clinical illness severity, 2) the lack of multiple TNF-alpha measurements in one patient to allow for trend analysis, 3) the lack of analysis of membrane-associated as well as secreted TNF-alpha levels, 4) the lack of concomitant analysis of soluble TNF-alpha receptors which may bind TNF-alpha in the serum, and 5) the possible requirement for more than one dysfunction in monocyte (M phi) TNF-alpha production and regulation to initiate pathology. Here, the MODS score was used to quantitate patients' illness severity over the length of their intensive care unit (ICU) stay. Patients' and normals' monocytes (stimulated and unstimulated) were assessed for production of secreted as well as membrane-associated TNF-alpha (sTNF and mTNF) and for shed p75 TNF-alpha receptor (TNFR) levels. These parameters of M phi TNF-alpha production and regulation were correlated to the MODS score as an indicator of clinical outcome. There was no correlation between sTNF and MODS score (p = .9025). There was a correlation between increased mTNF (p = .057) or decreased TNFR shedding (p = .0021) to increased MODS, but this lacked specificity. However, when the stimulated M phi production of mTNF and TNFR are expressed as the mTNF/TNFR ratio, an increased ratio correlates with high specificity to development of organ failure (p = .0002). These data indicate that a dual deregulation in M phi TNF-alpha production reflects increasing mTNF-alpha levels concomitant to decreased M phi shedding of neutralizing TNFR and correlates with the development of MODS. PMID:8961387

Pellegrini, J D; Puyana, J C; Lapchak, P H; Kodys, K; Miller-Graziano, C L

1996-12-01

45

Correlations of visual scores, carcass traits, feed efficiency and retail product yield in Nellore cattle  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The growing use of visual scores (VS) and ultrasound (US) for carcass evaluation in breeding programs, calls for a knowledge of the relationships between these traits and other relevant characteristics, such as feed efficiency and production of commercial cuts. The objective of this study was to eva [...] luate correlations between body visual scores and carcass traits identified by ultrasound (US) and feed efficiency (FE), carcass weight (HCW), dressing percentage (DP) and retail product yield (RPY) in beef cattle. Nellore cattle (male), 42 non-castrated [NCAST] and 44 castrated [CAST]) were evaluated by both VS and US, at the postweaning (15-month old) and finishing phases (21-month old). Visual scores of conformation (C), precocity (P) and muscling (M) were assessed and the backfat thickness (UBFT), rump fat thickness (URFT) and ribeye area (UREA) were measured by ultrasound. Gain-to-feed (G:F) ratio and residual feed intake (RFI) were measured in feedlot. Hot carcass weight, DP and RPY were determined at harvest. Non-castrated cattle had greater HCW and RPY but lower UBFT and URFT than CAST. Postweaning VS and US were poorly correlated with FE in both sexual conditions. Finishing VS were negatively correlated with G:F in CAST and finishing URFT was negatively correlated with RPY in NCAST. The relationship of VS and US with feed efficiency and meat yield is affected by age at the date of evaluation and by castration. Feed efficiency is not related to the yield of meat cuts in Nellore cattle

Paulo Henrique, Cancian; Rodrigo da Costa, Gomes; Fernando Ricardo, Manicardi; Andrea Cristina, Ianni; Marina de Nadai, Bonin; Paulo Roberto, Leme; Saulo da Luz e, Silva.

2014-02-01

46

Reliability of the Italian INFVo scale and correlations with objective measures and VHI scores.  

Science.gov (United States)

The objective of this study was to evaluate the reliability of the INFVo scale and its relationship with objective measures and VHI scores in 40 native Italian-speaking patients with substitution voice. The maximum phonation time (MPT), diadochokinesis (DDK) of the three syllabic sequence [pa/ta/ka], reading of a passage and a single word repetition test were recorded. Each patient completed the Italian version of the VHI. Three speech-language pathologists blindly rated the recordings using the auditory perceptual INFVo scale; one listened and assessed the voice recording twice. The INFVo intra- and inter-rater reliability reached good values. Strong to moderate correlations between the INFVo scale scores and MPT, DDK, distortions in the repetition test, speech rate during reading and the functional subscale of the VHI were found. In conclusion, the INFVo scale is a reliable tool and can be recommended for the perceptual assessment of substitution voices in Italian speaking patients. PMID:23853403

Schindler, A; Ginocchio, D; Atac, M; Maruzzi, P; Madaschi, S; Ottaviani, F; Mozzanica, F

2013-04-01

47

Correlacao do EuroSCORE com o surgimento de lesao renal aguda pos-operatoria em cirurgia cardiaca / Correlation of the EuroSCORE with the onset of postoperative acute kidney injury in cardiac surgery  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese OBJETIVO: Verificar se há correlação entre valores do EuroSCORE e o risco de desenvolver lesão renal aguda em pacientes submetidos à cirurgia cardíaca. MÉTODOS: Estudo retrospectivo, realizado em hospital terciário, em pacientes consecutivos com indicação para abordagem cirúrgica cardíaca (val [...] vares, isquêmicas e congênitas) entre outubro de 2010 a julho de 2011. RESULTADOS: Foram avaliados cem pacientes. Destes, seis foram excluídos (cinco por doença renal ou terapia dialítica prévias e um devido a informações incompletas no prontuário médico). As principais indicações cirúrgicas foram revascularização miocárdica em 55 pacientes (58,5% dos casos) e trocas valvares em 28 pacientes (29,8%). Conforme o EuroSCORE, 55 pacientes foram classificados como risco alto (58,5%), 27 pacientes como risco médio (28,7%) e 12 pacientes como risco baixo (12,8%). No período pós-operatório, 31 pacientes (33%) evoluíram com aumento da creatinina sérica (18 (19,1%) RIFLE "R"; 7 (7,4%) RIFLE "I"; e 6 (6,5%) RIFLE "F"). Na amostra considerada de alto risco pelos critérios do EuroSCORE, 24 pacientes (43,6%) apresentaram comprometimento renal agudo. Nos pacientes classificados como de médio e de baixo risco, ocorreu lesão renal aguda em 18,5 e 16,6% dos casos, respectivamente. A associação entre a estratificação de risco (baixo, médio e alto) do EuroSCORE e o escore do RIFLE pós-operatório foi estatisticamente significante (p=0,03). CONCLUSÃO: Na população estudada, houve correlação estatisticamente significante entre o EuroSCORE e o risco de desenvolvimento de lesão renal aguda no pós-operatório de cirurgia cardíaca. Abstract in english OBJECTIVE: The objective of this study was to assess the correlation between the European System for Cardiac Operative Risk Evaluation (EuroSCORE) score and the risk of developing acute kidney injury in cardiac surgery patients. METHODS: This retrospective study was conducted at a tertiary hos [...] pital on consecutive cardiac surgery patients (e.g., valvular, ischemic and congenital heart diseases) between October 2010 and July 2011. RESULTS: One hundred patients were assessed. Among the 100 patients, six were excluded, including five because of prior kidney disease or dialysis therapy and one because of incomplete medical records. The primary surgical indications were myocardial revascularization in 55 patients (58.5% of cases) and valve replacement in 28 patients (29.8%). According to the EuroSCORE, 55 patients were classified as high risk (58.5%), 27 patients as medium risk (28.7%) and 12 patients as low risk (12.8%). In the postoperative period, patients were classified with the Risk, Injury, Failure, Loss and End-stage kidney disease (RIFLE) score. Among the 31 patients (33%) who displayed an increase in serum creatinine, 18 patients (19.1%) were classified as RIFLE "R" (risk), seven patients (7.4%) were classified as RIFLE "I" (injury) and six patients (6.5%) were classified as RIFLE "F" (failure). Among the patients who were considered to be high risk according to the EuroSCORE criteria, 24 patients (43.6%) showed acute kidney injury. Among the patients who were classified as medium or low risk, acute kidney injury occurred in 18.5 and 16.6% of the cases, respectively. The correlations between risk stratification (low, medium and high) and the EuroSCORE and postoperative RIFLE scores were statistically significant (p=0.03). CONCLUSION: In the studied population, there was a statistically significant correlation between the EuroSCORE and the risk of developing acute kidney injury in the postoperative period after cardiac surgery.

Edmilson Bastos de, Moura; Saint-Clair Gomes, Bernardes Neto; Fabio Ferreira, Amorim; Renato Camargo, Viscardi.

2013-09-01

48

Ecological validity and neuroanatomical correlates of the NIH EXAMINER executive composite score.  

Science.gov (United States)

Executive functions refer to a constellation of higher-level cognitive abilities that enable goal-oriented behavior. The NIH EXAMINER battery was designed to assess executive functions comprehensively and efficiently. Performance can be summarized by a single score, the "Executive Composite," which combines measures of inhibition, set-shifting, fluency, and working memory. We evaluated the ecological validity of the Executive Composite in a sample of 225 mixed neurological patients and controls using the Frontal Systems Behavior Scale (FrSBe), an informant-based measure of real-world executive behavior. In addition, we investigated the neuroanatomical correlates of the Executive Composite using voxel-based morphometry in a sample of 37 participants diagnosed with dementia, mild cognitive impairment, or as neurologically healthy. The Executive Composite accounted for 28% of the variance in Frontal Systems Behavior Scale scores beyond age. Even after including two widely used executive function tests (Trails B and Stroop) as covariates, the Executive Composite remained a significant predictor of real-world behavior. Anatomically, poorer scores on the Executive Composite were associated with smaller right and left dorsolateral prefrontal volumes, brain regions critical for good executive control. Taken together, these results suggest that the Executive Composite measures important aspects of executive function not captured by standard measures and reflects the integrity of frontal systems. PMID:23764015

Possin, Katherine L; LaMarre, Amanda K; Wood, Kristie A; Mungas, Dan M; Kramer, Joel H

2014-01-01

49

Ecological Validity and Neuroantomical Correlates of the NIH EXAMINER Executive Composite Score  

Science.gov (United States)

Executive functions refer to a constellation of higher-level cognitive abilities that enable goal-oriented behavior. The NIH EXAMINER battery was designed to assess executive functions comprehensively and efficiently. Performance can be summarized by a single score, the ‘Executive Composite,’ which combines measures of inhibition, set-shifting, fluency, and working memory. We evaluated the ecological validity of the Executive Composite in a sample of 225 mixed neurological patients and controls using the Frontal Systems Behavior Scale (FrSBe), an informant-based measure of real-world executive behavior. In addition, we investigated the neuroanatomical correlates of the Executive Composite using voxel-based morphometry in a sample of 37 participants diagnosed with dementia, mild cognitive impairment, or as neurologically healthy. The Executive Composite accounted for 28% of the variance in FrSBe scores beyond age. Even after including two widely-used executive function tests (Trails B and Stroop) as covariates, the Executive Composite remained a significant predictor of real-world behavior. Anatomically, poorer scores on the Executive Composite were associated with smaller right and left dorsolateral prefrontal volumes, brain regions critical for good executive control. Taken together, these results suggest that the Executive Composite measures important aspects of executive function not captured by standard measures and reflects the integrity of frontal systems. PMID:23764015

Possin, Katherine L.; LaMarre, Amanda K.; Wood, Kristie; Mungas, Dan M.; Kramer, Joel H.

2014-01-01

50

Correlación entre score de calcio coronario, esteatosis hepática y síndrome metabólico / Correlation between coronary calcium score, hepatic steatosis and metabolic syndrome  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Objetivos. Demostrar la correlación que existe entre presencia o no de enfermedad coronaria establecida (medida a través del índice de Agatston) y esteatosis hepática en los segmentos visualizados del hígado al momento de realizar el score de calcio. Material y Métodos. Estudio retrospectivo que inc [...] luyó 229 pacientes con factores de riesgo para enfermedad coronaria a los que se les realizó tomografía computada multicorte de arterias coronarias o score de calcio. Se evaluó la presencia de enfermedad ateromatosa en arterias coronarias y aorta torácica y atenuación hepática en los segmentos visualizados del hígado. El análisis estadístico incluyó modelos de regresión lineal, estudio por asociación de múltiples variables y modelo CART. Resultados. 229 pacientes, 78% de sexo masculino y 22% femenino, con edad promedio 56 años. Se demostró asociación estadísticamente significativa entre mayor nivel de score de calcio y menor atenuación hepática, en pacientes de mayor edad y sexo masculino. Se logró definir dos tipos de pacientes con score de calcio elevado, un grupo con hipertensión arterial - esteatosis hepática y otro grupo con hipertensión arterial y diabetes tipo 2; los pacientes solamente obesos no tenían mayores niveles de score de calcio. Conclusiones. Existe asociación entre ateromatosis calcificada y esteatosis hepática. Los pacientes con esteatosis hepática como parte de un síndrome metabólico, tienen mayor riesgo de ateroesclerosis. Puede ser útil incorporar la evaluación de esteatosis hepática en la estratificación de riesgo cardiovascular. Abstract in english Objectives. To demonstrate the correlation between the presence or absence of established coronary disease (as measured by the Agatston index) and hepatic steatosis visualized in liver segments when calculating calcium score. Material and Methods. Retrospective study that included229 patients with r [...] isk factors for coronary disease who underwent multislice computed tomography of coronary arteries or calcium score. We evaluated the presence of atherosclerotic disease in coronary arteries and thoracic aorta and liver attenuation in visualized liver segments. Statistical analysis included linear regression models, association studies of multiple variables and CARTmodel. Results. 229 patients, 78% male, average age 56 years. It values statistically significant association was found between higher levels of calcium score and lower hepatic attenuation in older patients and males. We were to define two types of patients with high calcium score, a group with hypertension - hepatic steatosis and another groups with hypertension and type 2 diabetes; patients that were only obese did not have higher levels of calcium score. Conclusions. A relationship exists between calcified atheromatosis disease and hepatics steatosis. Patients with hepatics steatosis as part of a metabolic syndrome are at increased risk of atherosclerosis. It may be useful to incorporate the assessment of hepatics steatosis in cardiovascular risk stratification.

Karina, Hermosilla M; Daniela, Pivcevic C; Julia, Alegria B; Claudio, Silva F.

51

A new scoring system in cancer genetics: application to criteria for BRCA1 and BRCA2 mutation screening.  

OpenAIRE

BACKGROUND: In hereditary forms of cancer due to mutations of genes such as BRCA1 and BRCA2, methods have been proposed to predict the presence of a mutation in a family. METHODS: Relying on carriage probability computation is the most predictive, but scores are a good proxy and avoid using computer software. An empirical method, the Manchester scoring system, has been elaborated for BRCA1 and BRCA2 mutation identification. We propose a general scoring system based on a transformation of the ...

Bonai?ti, Bernard; Alarcon, Flora; Andrieu, Nadine; Bonadona, Vale?rie; Dondon, Marie-gabrielle; Pennec, Sophie; Stoppa-lyonnet, Dominique; Bonai?ti-pellie?, Catherine; Perdry, Herve?

2013-01-01

52

Big Macs and Eigenfactor Scores: Don't Let Correlation Coefficients Fool You  

CERN Document Server

The Eigenfactor Metrics provide an alternative way of evaluating scholarly journals based on an iterative ranking procedure analogous to Google's PageRank algorithm. These metrics have recently been adopted by Thomson-Reuters and are listed alongside the Impact Factor in the Journal Citation Reports. But do these metrics differ sufficiently so as to be a useful addition to the bibliometric toolbox? Davis (2008) has argued otherwise, based on his finding of a 0.95 correlation coefficient between Eigenfactor score and total citations for a sample of journals in the field of medicine. This conclusion is mistaken; here we illustrate the basic statistical fallacy to which Davis succumbed. We provide a complete analysis of the 2006 Journal Citation Reports and demonstrate that there are important differences between the information provided by the Eigenfactor Metrics and that provided by Impact Factor and Total Citations.

West, Jevin; Bergstrom, Carl

2009-01-01

53

Modified Chrispin-Norman chest radiography score for cystic fibrosis: observer agreement and correlation with lung function  

International Nuclear Information System (INIS)

To test observer agreement and two strategies for possible improvement (consensus meeting and reference images) for the modified Chrispin-Norman score for children with cystic fibrosis (CF). Before and after a consensus meeting and after developing reference images three observers scored sets of 25 chest radiographs from children with CF. Observer agreement was tested for line, ring, mottled and large soft shadows, for overinflation and for the composite modified Chrispin-Norman score. Correlation with lung function was assessed. Before the consensus meeting agreement between observers 1 and 2 was moderate-good, but with observer 3 agreement was poor-fair. Scores correlated significantly with spirometry for observers 1 and 2 (-0.72< R<-0.42, P < 0.05), but not for observer 3. Agreement with observer 3 improved after the consensus meeting. Reference images improved agreement for overinflation and mottled and large shadows and correlation with lung function, but agreement for the modified Chrispin-Norman score did not improve further. Consensus meetings and reference images improve among-observer agreement for the modified Chrispin-Norman score, but good agreement was not achieved among all observers for the modified Chrispin-Norman score and for bronchial line and ring shadows. (orig.)

54

Modified Chrispin-Norman chest radiography score for cystic fibrosis: observer agreement and correlation with lung function  

Energy Technology Data Exchange (ETDEWEB)

To test observer agreement and two strategies for possible improvement (consensus meeting and reference images) for the modified Chrispin-Norman score for children with cystic fibrosis (CF). Before and after a consensus meeting and after developing reference images three observers scored sets of 25 chest radiographs from children with CF. Observer agreement was tested for line, ring, mottled and large soft shadows, for overinflation and for the composite modified Chrispin-Norman score. Correlation with lung function was assessed. Before the consensus meeting agreement between observers 1 and 2 was moderate-good, but with observer 3 agreement was poor-fair. Scores correlated significantly with spirometry for observers 1 and 2 (-0.72correlation with lung function, but agreement for the modified Chrispin-Norman score did not improve further. Consensus meetings and reference images improve among-observer agreement for the modified Chrispin-Norman score, but good agreement was not achieved among all observers for the modified Chrispin-Norman score and for bronchial line and ring shadows. (orig.)

Jong, P.A. de; Achterberg, J.A.; Kessels, O.A.M.; Beek, F.J. [Department of Radiology, University Medical Center Utrecht, Wilhelmina Children' s Hospital, Utrecht (Netherlands); Ginneken, B. van; Hogeweg, L. [Radboud University Nijmegen Medical Centre, Department of Radiology, Nijmegen (Netherlands); Image Sciences Institute, University Medical Center Utrecht, Utrecht (Netherlands); Terheggen-Lagro, S.W.J. [University Medical Center Utrecht, Wilhelmina Children' s Hospital, Department of Pediatric Pulmonology, Utrecht (Netherlands)

2011-04-15

55

Admission Norton scale scores (ANSS) correlate with rehabilitation outcome and length in elderly patients following hip arthroplasty.  

Science.gov (United States)

We sought to determine if ANSS used for evaluating pressure sore risk also correlate with rehabilitation outcome and length following hip arthroplasty in elderly patients. This was a retrospective study conducted in a geriatric rehabilitation department during 2009. ANSS, admission albumin serum levels, mini-mental state examination (MMSE) scores, discharge walking functional independence measure (FIM) scores, and rehabilitation length were studied. The final cohort included 201 patients: 160 (79.6%) females and 41 (20.4%) males. Mean age was 82.7±6.5 years. Mean discharge walking FIM score was 5.2±0.9. Mean length of rehabilitation was 19.9±7.8 days. ANSS correlated with discharge walking FIM scores (r=0.28; p=0.002), and with length of rehabilitation (r=-0.22; p=0.014) following adjustment for age, admission albumin serum levels, and MMSE scores. Linear regression analysis showed that ANSS were associated with the discharge walking FIM scores (prehabilitation length (p=0.027) independent of age, admission albumin serum levels, gender, type of hip surgery, and the appearance of pressure sores. We conclude that the Norton scoring system may be used for predicting the outcome and the duration of rehabilitation in elderly patients following hip arthroplasty. PMID:21109314

Justo, Dan; Vislapu, Natalia; Shvedov, Victor; Fickte, Marina; Danylesko, Alexander; Kimelman, Polina; Merdler, Charlotte; Lerman, Yaffa

2011-01-01

56

Correlations among scores on measures of field dependence-independence cognitive style, cognitive ability, and sustained attention.  

Science.gov (United States)

The Children's Embedded Figures Test, the Rod and Frame Test to measure the field dependence-independence cognitive style, Cattell's Culture Fair Intelligence Tests to measure cognitive ability, and two cancellation tasks (Zazzo task and Bourdon task) to assess sustained attention were administered to 179 boys and 110 girls whose average age was 9.0 yr. Correlations between scores on measures of field dependence-independence and cognitive ability were moderated. Average correlations between scores on measures of field dependence-independence, cognitive ability, and measures of sustained attention was .23 for the Zazzo task and quite weak (.06) for the Bourdon task. PMID:10214649

Amador-Campos, J A; Kirchner-Nebot, T

1999-02-01

57

Ultrasound Doppler Score Correlates with OMERACT RAMRIS Bone Marrow Oedema and Synovitis Score in the Wrist Joint of Patients with Rheumatoid Arthritis  

DEFF Research Database (Denmark)

PURPOSE: MRI is considered the standard of reference for advanced imaging in rheumatoid arthritis (RA). However, in daily clinical practice ultrasound (US) imaging with Doppler information is more versatile and often used for fast and dynamic assessment of joint inflammation. The aim was to compare low-field MRI scores with the US Doppler measurements in the wrist joint of patients with RA. MATERIAL AND METHODS: Fifty consecutive patients with RA (46 women & 4 men) completed both low-field dedicated extremity MRI (E-scan®, Esaote) and a high-end US (Sequioa®, Siemens) imaging of the wrist before initiating either biological treatment (n = 26) or intraarticular injection of Depomedrole® (n = 24). Mean age was 56 years (range 21 - 83 years); mean disease duration 87.2 months (range 4 - 349 months), mean DAS 28 4,8 (range 2 - 7). MRI was scored according to the OMERACT RAMRIS recommendations and US Doppler colour-fractions were determined. RESULTS: Using Spearman's rho, we found a relatively good to moderate correlation between the US colour-fraction and the total OMERACT bone marrow oedema and synovitis scores on MRI (r = 0.6; p 

Boesen, M; Ellegaard, K

2012-01-01

58

Patients prefer boarding in inpatient hallways: correlation with the national emergency department overcrowding score.  

Science.gov (United States)

Objective. The boarding of patients in Emergency Department (ED) hallways when no inpatient beds are available is a major cause of ED crowding. One solution is to board admitted patients in an inpatient rather than ED hallway. We surveyed patients to determine their preference and correlated their responses to real-time National Emergency Department Overcrowding Score (NEDOCS). Methods. This was a survey of admitted patients in the ED of an urban university level I trauma center serving a community of 5 million about their personal preferences regarding boarding. Real-time NEDOCS was calculated at the time each survey was conducted. Results. 99 total surveys were completed during October 2010, 42 (42%) patients preferred to be boarded in an inpatient hallway, 33 (33%) preferred the ED hallway, and 24 (24%) had no preference. Mean (±SD) NEDOCS (range 0-200) was 136 ± 46 for patients preferring inpatient boarding, 112 ± 39 for ED boarding, and 119 ± 43 without preference. Male patients preferred inpatient hallway boarding significantly more than females. Preference for inpatient boarding was associated with a significantly higher NEDOCS. Conclusions. In this survey study, patients prefer inpatient hallway boarding when the hospital is at or above capacity. Males prefer inpatient hallway boarding more than females. The preference for inpatient hallway boarding increases as the ED becomes more crowded. PMID:22235374

Richards, John R; Ozery, Gal; Notash, Mark; Sokolove, Peter E; Derlet, Robert W; Panacek, Edward A

2011-01-01

59

Rheumatoid arthritis bone erosion volumes on CT and MRI: reliability and correlations with erosion scores on CT, MRI and radiography.  

DEFF Research Database (Denmark)

OBJECTIVES: To investigate intramodality and intermodality agreements of CT and MRI erosion volumes in metacarpophalangeal (MCP) joints in rheumatoid arthritis (RA), and to compare the volumes with erosion scores for CT, MRI and radiography. METHODS: In total, 17 patients with RA and four healthy controls underwent unilateral CT, MRI and radiography of second to fifth MCP joints in one hand. Erosion volumes (using OSIRIS software) and scores were determined from CT, MRI and radiography (scores only). RESULTS: CT, MRI and radiography detected 77, 62 and 12 erosions, respectively. On CT, the mean erosion volume was 26 mm(3) (median 10; range 0 to 248) and 30 mm(3) (18; 1 to 163) on MRI. Total erosion volumes (per patient/control) were 97 mm(3) (29; 0 to 485) on CT and 90 mm(3) (46; 0 to 389) on MRI. For volumes, Spearman correlation coefficients were 0.96 to 0.99 (CT vs CT), 0.95 to 0.98 (MRI vs MRI) and 0.64 to 0.89 (CT vs MRI), all p<0.01. MRI erosion volumes correlated with the Outcome Measures in Rheumatology Clinical Trials/Rheumatoid Arthritis Magnetic Resonance Imaging Score (OMERACT RAMRIS) erosion scores (0.91 to 0.99; p<0.01) and the Sharp/van der Heijde erosion score (0.49 to 0.63; p<0.01). CONCLUSION: Very high intramodality and high intermodality agreements of CT and MRI erosion volumes were found, encouraging further testing in longitudinal studies. A close correlation with CT and MRI erosion volumes supports the OMERACT RAMRIS erosion score as a valid measure of joint destruction in RA.

MØller DØhn, Uffe; Ejbjerg, Bo J

2007-01-01

60

A Comparison of Empirical Differential Option Weighting Scoring Procedures as a Function of Inter-Item Correlation  

Science.gov (United States)

The reliabilities yielded by several differential option weighting scoring procedures were compared among themselves as well as against conventional testing. It was found that increases in reliability due to differential option weighting were a function of inter-item correlations. Suggestions for the implementation of differential option weighting…

Bejar, Issac I.; Weiss, David J.

1977-01-01

61

PERFORMANCE RANKING OF DIPLOMA INSTITUTIONS BASED ON SOME SELECTED CRITERIA BY APPLYING SCORING MODEL- A SAMPLE STUDY  

Directory of Open Access Journals (Sweden)

Full Text Available The assessment of institutional performance based on various contributing parameters is of paramount importance for an institute and is not an easy task. Present studies aim at assessing the institutional level performance of some selected diploma level institutions of West Bengal by using Scoring Model (SM - as a multiple criterion decision making technique. Application of this model also shows a comparison of institutions based on their performance with respect to specific contributing parameters.

Dipankar Bose

2011-10-01

62

Quick score of hormone receptor status of breast carcinoma: Correlation with the other clinicopathological prognostic parameters  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Immunohistochemical assessment of the hormone receptor status of breast carcinoma is a routine investigation. However, there is no worldwide consensus on the scoring system. The Quick Score is claimed to be a reliable scoring system, which assesses both the proportion of stained cells and the intensity of staining. Aims: To assess the value of Quick Score in terms of accepted clinicopathological parameters and to document the prevalence of hormone receptor-positive breast carcinomas in the study sample. Materials and Methods: Clinicopathological parameters of 151 breast cancers were compared with the Quick Scores for estrogen receptor (ER and progesterone receptor (PR status. Results and Conclusions: The Quick Score for ER was 0 in 54.3% (82/151 and for PR was 0 in 51.7% (75/145, indicating no hormone receptor expression in the majority. The Nottingham grade and the mitotic count had a significant inverse relationship with the Quick Score for hormone receptor status. The Nottingham Prognostic Index (NPI also had an inverse relationship with the hormone receptor status.

Mudduwa Lakmini

2009-04-01

63

Severity assessment of pulmonary embolism using dual energy CT - correlation of a pulmonary perfusion defect score with clinical and morphological parameters of blood oxygenation and right ventricular failure  

International Nuclear Information System (INIS)

To correlate a Dual Energy (DE)-based visual perfusion defect scoring system with established CT-based and clinical parameters of pulmonary embolism (PE) severity. In 63 PE patients, DE perfusion maps were visually scored for perfusion defects (P-score). Vascular obstruction was quantified using the Mastora score. Both scores were correlated with short-axis diameters of the right and left ventricle, their ratio (RV/LV ratio), width of the pulmonary trunk, a number of clinical parameters and each other. Univariate and multivariate analyses were performed. Times to generate both scores were recorded. After univariate and multivariate analysis, a significant (p 2 (r = -0.50). For the left ventricular diameter, only univariate analysis showed a significant correlation. Mastora score correlated significantly with RV/LV ratio (r = 0.36), width of the pulmonary trunk (r = 0.27), PaO2 (r = -0.41) and troponin I (r = 0.37). Mean time for generating the P-score was significantly shorter than for the Mastora score. A DE-based P-score correlates with a number of parameters of PE severity. It might be easier and faster to perform than some traditional CT scoring methods for vascular obstruction. (orig.)

64

Efficacy of HUMN criteria for scoring the micronucleus assay in human lymphocytes exposed to a low concentration of p,p'-DDT.  

Science.gov (United States)

The cytokinesis-block micronucleus (CBMN) assay is one of the standard cytogenetic tools employed to assess chromosomal damage subsequent to exposure to genotoxic/cytotoxic agents, and is widely applicable to plant, animal and human cells. In the present study, the CBMN assay was used to assess the baseline damage in binuclear human peripheral blood lymphocytes exposed to 25 microg/L p,p'-DDT for 1, 2, 24, and 48 h by measuring the frequency of micronuclei, nucleoplasmic bridges and nuclear buds. These new scoring criteria facilitated the detection of different types of clastogenic and aneugenic effects induced by this type of pollutant. With these criteria, CBMN can also be used to measure nucleoplasmic bridges which are considered to be consequences of chromosome rearrangements and nuclear buds which are biomarkers of altered gene amplification and gene dosage. The total number of micronuclei observed in binuclear human peripheral blood lymphocytes of the exposed samples (ranging from 32 to 47) was significantly greater (P < 0.05) than that detected in the unexposed (0 time) control sample, where the total number of micronuclei was 7. The number of nucleoplasmic bridges and nuclear buds obtained after 24 and 48 h was also significantly (P < 0.05) greater in the samples treated with p,p'-DDT than in the unexposed control samples. Thus, our results confirmed the usefulness of the new criteria applicable for the CBMN assay employed in measuring the DNA damage and its role of a sensitive cytogenetic biomarker. PMID:18592119

Garaj-Vrhovac, V; Gajski, G; Ravli?, S

2008-06-01

65

Quantification of Emphysema with a Three-Dimensional Chest CT Scan: Correlation with the Visual Emphysema Scoring on Chest CT, Pulmonary Function Tests and Dyspnea Severity  

Energy Technology Data Exchange (ETDEWEB)

We wanted to prospectively evaluate the correlation between the quantification of emphysema using 3D CT densitometry with the visual emphysema score, pulmonary function tests (PFT) and the dyspnea score in patients with chronic obstructive pulmonary disease (COPD). Non-enhanced chest CT with 3D reconstruction was performed in 28 men with COPD (age 54-88 years). With histogram analysis, the total lung volume, mean lung density and proportion of low attenuation lung volume below predetermined thresholds were measured. The CT parameters were compared with the visual emphysema score, the PFT and the dyspnea score. A low attenuation lung volume below -950 HU was well correlated with the DLco and FEV{sub 1}/FVC. A Low attenuation lung volume below -950 HU and -930 HU was correlated with visual the emphysema score. A low attenuation lung volume below -950 HU was correlated with the dyspnea score, although the correlations between the other CT parameters and the dyspnea score were not significant. Objective quantification of emphysema using 3D CT densitometry was correlated with the visual emphysema score. A low attenuation lung volume below -950 HU was correlated with the DLco, the FEV{sub 1}/FVC and the dyspnea score.

Park, Hyun Jeong; Hwang, Jung Hwa [Dept. of Radiology, Soonchunhyang University Seoul Hospital, Seoul (Korea, Republic of)

2011-09-15

66

Computing exact p-values for a cross-correlation shotgun proteomics score function.  

Science.gov (United States)

The core of every protein mass spectrometry analysis pipeline is a function that assesses the quality of a match between an observed spectrum and a candidate peptide. We describe a procedure for computing exact p-values for the oldest and still widely used score function, SEQUEST XCorr. The procedure uses dynamic programming to enumerate efficiently the full distribution of scores for all possible peptides whose masses are close to that of the spectrum precursor mass. Ranking identified spectra by p-value rather than XCorr significantly reduces variance because of spectrum-specific effects on the score. In combination with the Percolator postprocessor, the XCorr p-value yields more spectrum and peptide identifications at a fixed false discovery rate than Mascot, X!Tandem, Comet, and MS-GF+ across a variety of data sets. PMID:24895379

Howbert, J Jeffry; Noble, William Stafford

2014-09-01

67

Correlation between Grades in the Medical Basic Science Course and Scores on the Comprehensive Basic Sciences Exam in Iran  

OpenAIRE

Introduction: Medical students in Iran are required to undertake a Basic Sciences Comprehensive Exam (BSCE) at the end of their BS course in order to progress to the next stage of medical education. BSCE results are widely used to evaluate medical education programs among different medical universities. The aim of this study is to explore the correlation between BSCE results and students’ mean BS course scores.Methods: A cross-sectional study, using secondary data analysis, was carried out ...

Hamidreza Mahboobi; Ebrahim Khajeh; Nazanin Sharif; Zahra Jahangiri; Tahereh Khorgoei; Keramat Allah Jahanshahi; Mohammad Esmaeil Shahrzad; Elizabeth Cottrell

2010-01-01

68

Brochopulmonary dysplasia: New high resolution computed tomography scorting system and correlation between the high resolution computed tomography score and clinical severity  

Energy Technology Data Exchange (ETDEWEB)

To develop an high resolution computed tomography (HRCT) scoring system for the assessment of bronchopulmonary dysplasia (BPD) and determine its usefulness as compared with the chest radiographic score. Forty-two very low-birth-weight preterm infants with BPD (25 male, 17 female) were prospectively evaluated with HRCT performed at the mean age of 39.1-week postmenstrual age. Clinical severity of BPD was categorized as mild, moderate or severe. The HRCT score (0-36) of each patient was the sum of the number of bronchopulmonary segments with 1) hyperaeration and 2) parenchymal lesions (linear lesions, segmental atelectasis, consolidation and architectural distortion), respectively. We compared the HRCT scores with the chest radiographic scores (the Toce system) in terms of correlation with clinical severity. The HRCT score had good interobserver (r = 0.969, p < 0.001) and intraobserver (r = 0.986, p < 0.001) reproducibility. The HRCT score showed better correlation (r = 0.646, p < 0.001) with the clinical severity of BPD than the chest radiographic score (r = 0.410, p = 0.007). The hyperaeration score showed better correlation (r = 0.738, p < 0.001) with the clinical severity of BPD than the parenchymal score (r = 0.523, p < 0.001). We have developed a new HRCT scoring system for BPD based on the quantitative evaluation of pulmonary abnormalities of BPD consisting of the hyperaeration score and the parenchymal score. The HRCT score shows better correlation with the clinical severity of BPD than the radiographic score.

Shin, Sumi; Kim, Woo Sun; Cheon, Jung Eun; Kim, Han Suk; Lee, Whal; Jung, Ah Young; Kim, In One; Choi, Jung Hwan [Seoul National University College of Medicine, Seoul (KR)

2013-04-15

69

The Correlation of Brody High Resolution Computed Tomography Scoring System with Clinical Status and Pulmonary Function Test in Patients with Cystic Fibrosis  

Directory of Open Access Journals (Sweden)

Full Text Available Background: To reduce the mortality and morbidity rates of cystic fibrosis (CF patients, and to have an effective clinical management, it is important to monitor the progression of the disease. The aim of this study was to evaluate the progression of lung disease in CF patients by means of assessing the correlation of the CT scoring system with clinical status and pulmonary function test at the Pediatric Pulmonary Ward of Masih Daneshvari Hospital in 2008. Methods: Pulmonary high resolution computed tomography (HRCT was performed in 23 CF patients using the Brody's scoring system. Morphologic signs as well as the extent and severity of each sign were scored, and the total score was calculated. The correlation of HRCT scores (total score as well as the score for each parameter with Shwachman Kuczycki scoring system and pulmonary function test were examined. Results: The study included 9 female and 14 male patients with an age range of 5-23 years (mean: 13.42 years. Bronchiectasis (100% and peribronchial wall thickening (100% were the most frequent CT abnormalities. Mucus plugging, air trapping and parenchymal involvements were respectively seen in 95.7%, 91.3% and 47.8% of patients. The overall CT score for all patients was 57.6±24.2 (means±SD. The results of pulmonary function test showed a restrictive pattern; however, in 5.3% of the patients PFT was normal. The overall Shwachman-Kulczycki score was 53.48±13.8. There was a significantly (P=0.015 negative correlation between the total CT score and Shwachman-Kulczycki score; however, there was no significant correlation between total CT score and the results of PFT (P=0.481. Conclusion: The Brody's scoring system for high resolution computed tomography seems to be a sensitive and efficient method to evaluate the progression of CF, and can be more reliable when we combine the CT scores with clinical parameters

Soheila Khalilzadeh

2011-03-01

70

Brochopulmonary dysplasia: New high resolution computed tomography scorting system and correlation between the high resolution computed tomography score and clinical severity  

International Nuclear Information System (INIS)

To develop an high resolution computed tomography (HRCT) scoring system for the assessment of bronchopulmonary dysplasia (BPD) and determine its usefulness as compared with the chest radiographic score. Forty-two very low-birth-weight preterm infants with BPD (25 male, 17 female) were prospectively evaluated with HRCT performed at the mean age of 39.1-week postmenstrual age. Clinical severity of BPD was categorized as mild, moderate or severe. The HRCT score (0-36) of each patient was the sum of the number of bronchopulmonary segments with 1) hyperaeration and 2) parenchymal lesions (linear lesions, segmental atelectasis, consolidation and architectural distortion), respectively. We compared the HRCT scores with the chest radiographic scores (the Toce system) in terms of correlation with clinical severity. The HRCT score had good interobserver (r = 0.969, p < 0.001) and intraobserver (r = 0.986, p < 0.001) reproducibility. The HRCT score showed better correlation (r = 0.646, p < 0.001) with the clinical severity of BPD than the chest radiographic score (r = 0.410, p = 0.007). The hyperaeration score showed better correlation (r = 0.738, p < 0.001) with the clinical severity of BPD than the parenchymal score (r = 0.523, p < 0.001). We have developed a new HRCT scoring system for BPD based on the quantitative evaluation of pulmonary abnormalities of BPD consisting of the hyperaeration score and the parenchymal score. The HRCT score shows better correlation with the clinical severity of BPD than the radiographic score.

71

Severity assessment of pulmonary embolism using dual energy CT - correlation of a pulmonary perfusion defect score with clinical and morphological parameters of blood oxygenation and right ventricular failure  

Energy Technology Data Exchange (ETDEWEB)

To correlate a Dual Energy (DE)-based visual perfusion defect scoring system with established CT-based and clinical parameters of pulmonary embolism (PE) severity. In 63 PE patients, DE perfusion maps were visually scored for perfusion defects (P-score). Vascular obstruction was quantified using the Mastora score. Both scores were correlated with short-axis diameters of the right and left ventricle, their ratio (RV/LV ratio), width of the pulmonary trunk, a number of clinical parameters and each other. Univariate and multivariate analyses were performed. Times to generate both scores were recorded. After univariate and multivariate analysis, a significant (p < 0.05) correlation with the P-score was shown for the Mastora score (r = 0.65), RV/LV ratio (r = 0.47), width of the pulmonary trunk (r = 0.26), troponin I (r = 0.43) and PaO{sub 2} (r = -0.50). For the left ventricular diameter, only univariate analysis showed a significant correlation. Mastora score correlated significantly with RV/LV ratio (r = 0.36), width of the pulmonary trunk (r = 0.27), PaO{sub 2} (r = -0.41) and troponin I (r = 0.37). Mean time for generating the P-score was significantly shorter than for the Mastora score. A DE-based P-score correlates with a number of parameters of PE severity. It might be easier and faster to perform than some traditional CT scoring methods for vascular obstruction. (orig.)

Thieme, Sven F. [Ludwig-Maximilians-Universitaet, Department of Clinical Radiology, Muenchen (Germany); Institut fuer Klinische Radiologie der LMU Muenchen, Muenchen (Germany); Ashoori, Nima; Bamberg, Fabian; Sommer, Wieland H.; Johnson, Thorsten R.C.; Maxien, Daniel; Helck, Andreas D.; Reiser, Maximilian F.; Nikolaou, Konstantin [Ludwig-Maximilians-Universitaet, Department of Clinical Radiology, Muenchen (Germany); Leuchte, Hanno; Becker, Alexander [Ludwig-Maximilians-Universitaet, Department of Medicine I, Muenchen (Germany); Behr, Juergen [Ludwig-Maximilians-Universitaet, Department of Medicine I, Muenchen (Germany); Berufsgenossenschaftliches Universitaetsklinikum Bergmannsheil GmbH Ruhr-Universitaet Bochum, Department of Medicine III, Bochum (Germany)

2012-02-15

72

Evaluation of selection criteria in Cicer arietinum L. using correlation coefficients and path analysis  

Directory of Open Access Journals (Sweden)

Full Text Available The study pertaining to the evaluation of selection criteria in chickpea using correlation coefficients and path analysis was carried out in the Department of Plant Breeding and Genetics, University of Agriculture, Faisalabad for a period of two years. Experimental material comprised of twenty chickpea genotypes. The genotypes demonstrated highly significant differences (P<0.01 for all the traits studied. The results of correlation analysis revealed that that grain yield plant-1 had significant genotypic and highly significant phenotypic relationship with primary branches, pods plant-1, seeds plant-1, seeds pod-1 and total biological yield. The path coefficient analysis based on grain yield plant-1, as a dependent variable, exposed that all of the other traits, except days to flowering, days to maturity and secondary branches exhibited positive direct effects. The path analysis confirmed that biological yield followed by number of seeds pod-1, 100-grain weight, had the maximum positive direct influence on grain yield plant-1. Therefore, this study suggests that chickpea improvement progarmme could be based on these characters as selection criteria.

Muhammad Amjad Ali

2009-03-01

73

Correlation between Grades in the Medical Basic Science Course and Scores on the Comprehensive Basic Sciences Exam in Iran  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Medical students in Iran are required to undertake a Basic Sciences Comprehensive Exam (BSCE at the end of their BS course in order to progress to the next stage of medical education. BSCE results are widely used to evaluate medical education programs among different medical universities. The aim of this study is to explore the correlation between BSCE results and students’ mean BS course scores.Methods: A cross-sectional study, using secondary data analysis, was carried out in 2007 in Hormozgan University of Medical Sciences (HUMS in Iran. Data from the 20th BSCE (held in 1998 to the 36th BSCE (held in 2006 was collected. All medical students who took these exams and for whom the mean results of the BS course and the BSCE were available were eligible for inclusion in the study. For each medical student, data were obtained regarding age at the time of participation in BSCE, together with sex, entrance year, zone as categorised by the national quota system, mean BS course scores, BSCE result, duration of BS course (number of semesters and number of failed semesters. Students whose data was not complete were excluded from the study. Data was analysed by using SPSS 15 (SPSS Inc., Chicago, Illinois, USA software.Results: 372 students undertook the BSCE during the research study period. Complete data was available for 365 medical students (98.1%. Among the participants, 224 (61.4% were female and 141 (38.6% were male. The mean age at the time of sitting the BSCE was 22.01±1.22. Mean BSCE scores were higher among students who had not previously failed a semester and who also finished the BS course within five semesters. Students with higher BS course scores had higher BSCE scores (P=0.000.Conclusions: Students’ BS course scores were found to correlate to BSCE results. Hence it may be prudent to identify medical students with low BS course scores, in order to provide additional educational support to improve their medical knowledge and thereby enhance their performance on the BSCE.

Hamidreza Mahboobi

2010-07-01

74

Ecological Validity and Neuroantomical Correlates of the NIH EXAMINER Executive Composite Score  

OpenAIRE

Executive functions refer to a constellation of higher-level cognitive abilities that enable goal-oriented behavior. The NIH EXAMINER battery was designed to assess executive functions comprehensively and efficiently. Performance can be summarized by a single score, the ‘Executive Composite,’ which combines measures of inhibition, set-shifting, fluency, and working memory. We evaluated the ecological validity of the Executive Composite in a sample of 225 mixed neurological patients and co...

Possin, Katherine L.; Lamarre, Amanda K.; Wood, Kristie; Mungas, Dan M.; Kramer, Joel H.

2013-01-01

75

Serum Gamma-Glutamyltransferase Concentration Correlates with Framingham Risk Score in Koreans  

OpenAIRE

Gamma-glutamyltransferase (GGT) is a novel coronary artery disease (CAD) risk factor, but its use as an independent factor for CAD risk prediction remains unclear in Asian population. This study examined the association between serum GGT concentration and Framingham risk score (FRS) in the Korean population. This cross-sectional study was performed on 30,710 Koreans. Besides FRS, body mass index, fasting blood glucose, liver enzymes, lipid profile, uric acid and high sensitive C-reactive prot...

Kim, Kyu-nam; Kim, Kwang-min; Lee, Duck-joo; Joo, Nam-seok

2011-01-01

76

Clinical Correlates of Hachinski Ischemic Score and Vascular Factors in Cognitive Function of Elderly  

OpenAIRE

The aim of this study is to investigate the relationship between Hachinski ischemic score (HIS) and vascular factors as well as between HIS and the cognitive function in elderly community. Demographic characteristics, such as sex, age, education, history of drinking and smoking, family history of dementia and stroke, diabetes mellitus, hypertension, hyperlipidemia, cardiovascular disease, stroke, and dementia, were surveyed. Neurological examination was administered to every subject and HIS w...

Youn Ho Kim; Oh Dae Kwon

2014-01-01

77

Reliability of the Italian INFVo scale and correlations with objective measures and VHI scores  

OpenAIRE

The objective of this study was to evaluate the reliability of the INFVo scale and its relationship with objective measures and VHI scores in 40 native Italian-speaking patients with substitution voice. The maximum phonation time (MPT), diadochokinesis (DDK) of the three syllabic sequence [pa/ta/ka], reading of a passage and a single word repetition test were recorded. Each patient completed the Italian version of the VHI. Three speech-language pathologists blindly rated the recordings using ...

Schindler, A.; Ginocchio, D.; Atac, M.; Maruzzi, P.; Madaschi, S.; Ottaviani, F.; Mozzanica, F.

2013-01-01

78

Changes in metamorphopsia in daily life after successful epiretinal membrane surgery and correlation with M-CHARTS score  

Directory of Open Access Journals (Sweden)

Full Text Available Takamasa Kinoshita,1,2 Hiroko Imaizumi,1 Hirotomo Miyamoto,1 Utako Okushiba,1 Yuki Hayashi,2 Takashi Katome,2 Yoshinori Mitamura2 1Department of Ophthalmology, Sapporo City General Hospital, Sapporo, Japan; 2Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan Purpose: To determine the correlation between the changes in metamorphopsia in daily life environment and the M-CHARTS scores after epiretinal membrane (ERM removal, and to determine the criterion for determining whether clinically significant changes in the metamorphopsia score have occurred in M-CHARTS. Methods: We studied 65 eyes undergoing vitrectomy for unilateral ERM. Self-administered questionnaires were used to examine the metamorphopsia in their daily life. The degree of metamorphopsia was determined by M-CHARTS. The receiver operating characteristic curve was used to determine the best predictor of the changes in metamorphopsia in daily life. To determine the reproducibility of the M-CHARTS score, another set of 56 eyes with ERM was tested twice on two different days. Results: The postoperative changes in the logarithm of the M-CHARTS score was defined as M2-value. The area under the receiver operating characteristic curve for the M2-value as a predictor of the changes in metamorphopsia in daily life was larger than area under the receiver operating characteristic curve obtained for any other parameter. The optimal cutoff value was -0.4. The 95% limits of agreement between test and retest measurements had a reproducibility of ±0.3 logarithm of the M-CHARTS score. Taking into account not only the reproducibility but also the consistency with the subjective changes, we determined the criterion for clinically significant changes in the M-CHARTS scores as a change of the M2-value by ?0.4. Conclusion: Evaluating the changes in the M-CHARTS scores in logarithmic form is favorable not only theoretically but also from the perspective of consistency with the subjective changes. Keywords: metamorphopsia score, ERM, criterion, vitrectomy 

Kinoshita T

2015-02-01

79

Contrast-enhanced ultrasonography for the detection and characterization of prostate cancer: Correlation with microvessel density and Gleason score  

International Nuclear Information System (INIS)

Aim: To determine whether there is a correlation between the peak intensity of the lesion at contrast-enhanced ultrasonography and the microvessel density (MVD) and Gleason score in biopsy specimens of prostate cancer. Materials and methods: Contrast-enhanced ultrasonography using cadence-contrast pulse sequence (CPS) technology was performed in 147 patients with suspected prostate cancer before biopsy. An auto-tracking contrast quantification (ACQ) software was used to analyse the peak intensity (PI) of the lesion. The Gleason score and MVD immunoreactivity were determined in the prostate biopsy specimens. Ultrasound findings were correlated with biopsy findings. Results: Prostate cancer was detected in 73 of 147 patients. The PI values of prostate cancer patients were significantly higher than those of non-malignant patients [9.81 (4.23) versus 5.69 (3.19) dB; p 0.05). Conclusion: The PI obtained by CPS harmonic ultrasonography appears to be of value as an indicator of MVD and increases with a higher Gleason score. CPS harmonic ultrasonography could be promising as a useful imaging technique in the detection and characterization of prostate cancer.

80

Correlation between semiquantitative myocardial perfusion score and absolute myocardial flow in {sup 13}N-ammonia PET  

Energy Technology Data Exchange (ETDEWEB)

{sup 13}N-ammonia is a well known radiopharmaceutical for the measurement of a myocardial blood flow (MBF) non-invasively using PET-CT. In this study, we investigated a correlation between MBF obtained from dynamic imaging and myocardial perfusion score (MPS) obtained from static imaging for usefulness of cardiac PET study. Twelve patients (11 males, 1 female, 57.9 {+-} 8.6 years old) with suspicious coronary artery disease underwent PET-CT scan. Dynamic scans (6 min: 5 sec X 12, 10 sec X 6, 20 sec X 3, and 30 sec X 6) were initiated simultaneously with bolus injection of 11 MBq/kg {sup 13}N-ammonia to acquire rest and stress image. Gating image was acquired during 13 minutes continuously. Nine-segment model (4 basal walls, 4 mid walls, and apex) was used for a measurement of MBF. Time activity curve of input function and myocardium was extracted from ROI methods in 9 regions for quantification. The MPS were evaluated using quantitative analysis software. To compare between 20-segment model and 9-segment model, 6 basal segments were excluded and averaged segmental scores were used. There are weak correlation between MBF (rest, 0.18-2.38 ml/min/g; stress, 0.40-4.95 ml/min/g) and MPS (rest 22-91%, stress, 14-90%), however the correlation coefficient between corrected MBF and MPS in rest state was higher than stress state (rest r=0.59; stress r=0.80). As a thickening increased, correlation between MBF and MPS also showed good correlation at each segments. Corrected and translated MPS as its characteristics using {sup 13}N-ammonia showed good correlation with absolute MBF measured by dynamic image in this study. Therefore, we showed MPS is one of good indices which reflect MBF. We anticipate PET-CT could be used as useful tool for evaluation of myocardial function in nuclear cardiac study.

Lee, Byeong Il; Kim, Jung Young; Min, Jung Joon; Song, Ho Chun; Bom, Hee Seung [Chonnam National University Hospital, Hwasun (Korea, Republic of); Kim, Kye Hun [Chonnam National University Medical School, Gwangju (Korea, Republic of); Kim, Su Jin; Lee, Jae Sung [Seoul National University College of Medicine, Seoul (Korea, Republic of)

2007-06-15

81

Correlation between PSA, bone scan and Gleason score in patients with prostate cancer  

International Nuclear Information System (INIS)

Full text: Prostate cancer is the third most common cancer among Peruvian males. Although radionuclide bone scans (BS) are frequently recommended as part of the staging evaluation for newly diagnosed prostate cancer, most scans are negative for metastases. It has been suggested that a routine bone scan is unnecessary in recently diagnosed prostate cancer if serum PSA is under 10 ng/mL. We hypothesized that Gleason score plus prostate-specific antigen (PSA), could predict for a positive bone scan (better that PSA alone), and that a low - risk group of patients could be identified in whom BS might be omitted. All patients who had both pathologic review of their prostate cancer biopsies and radionuclide BS at our institution from 1/93 to 12/95 were studied. Gleason score, PSA, and bone scan (Soloway Index) were determined in 165 patients. Bivariate analysis using chi (x2) was performed. The mean age of the 165 patients was 71.3 years, 109/165 (66.1%) had a 7-9 Gleason score and only 9/165 (5.5%) were well differentiated prostrate cancer. 82/165 (49.7%) had negative BS. When classifying patients according to their histological grade, the PSA median values were 11.8 ng/mL, 74.8 ng/mL and 116.4 ng/mL in well, median and poorly differentiated prostate cancer respectively. Using a cut off point of 10 ng/mL of PSA, the probability of having a positive BS in Gleason 7, 8 and 9 tumors were 0.109, 0.121 and 0.133 respectively. By using a cut off point of 20 ng/mL of PSA the possicut off point of 20 ng/mL of PSA the possibility to have a positive BS in Gleason 7, 8 and 9 tumours were 0.182, 0.206 and 0.224 respectively. Gleason score plus PSA were independent predictors for a positive radionuclide BS in newly diagnosed prostate cancer patients. Considering that most of our patients have Gleason 7-9, the risk of bone metastases despite PSA levels between 10 - 20 ng/mL is not negligible. In our opinion, it is important to continue including bone scan in the staging assessment of prostate cancer. (author)

82

Feeding practices correlated with authoritative parenting style and responsive feeding style scores  

Science.gov (United States)

Study objective was to identify correlations of authoritative parenting and responsive feeding styles with parental practices and child behaviors previously found to protect children from or increase risk of child obesity. Participants were 144 low-income mothers of 3- to 5-year-old children (71 gir...

83

State level correlations between high heart attack and stroke symptomology knowledge scores and CVD risk factors and mortality rates  

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Full Text Available Introduction: In 2008, cardiovascular disease (CVD accounted for one in three deaths in the United States. Epidemiological analyses suggest that two or more risk factors are the indicator of high risk and/or poor CVD outcomes. Knowledge of heart attack and stroke symptomology has been the focus of much research based on the assumption that accurate identification of an event is critical to reducing time to treatment. There is a paucity of research showing a clear association between knowledge of heart attack and stroke symptomology, risk factors, and mortality rates. In this study, we hypothesized that high stroke and heart attack symptomology knowledge scores would correspond to lower stroke or CVD mortality rankings as well as to a lower prevalence of two or more CVD risk factors. Methods: State was the unit of analysis used to examine data from two different sources and combined into a customized database. The first source was a multiyear Behavioral Risk Factor Surveillance Survey (BRFSS heart attack and stroke symptom knowledge module database. CVD and stroke mortality data used came from the American Heart Association’s (AHA 2012 Heart Disease and Stroke Statistics Update. Spearman’s Rho was the test statistic. Results: A moderate negative correlation was found between high heart attack and stroke symptom knowledge scores and the percentage of adults with two or more CVD or stroke risk factors. Likewise, a similar correlation resulted from the two variables, high heart attack and stroke symptoms knowledge score and CVD mortality rank. Conclusions: This study demonstrated a significant relationship between high heart attack and stroke symptom knowledge and lower CVD mortality rates and lower prevalence of two or more CVD risk factors at the state level. Our findings suggest that it is important to continue education efforts regarding heart attack and stroke symptom knowledge. Pharmacists are one group of health care providers who could enhance the needed public health education efforts.

Mary Nawal Lutfiyya

2013-09-01

84

Correlation between a new visual prostate symptom score (VPSS) and uroflowmetry parameters in men with lower urinary tract symptoms  

Scientific Electronic Library Online (English)

Full Text Available SciELO South Africa | Language: English Abstract in english OBJECTIVE: A visual prostate symptom score (VPSS) compared with the international prostate symptom score (IPSS) for evaluation of lower urinary tract symptoms (LUTS) can be completed without physician assistance by a significantly larger proportion of men with limited education. We aimed to evaluate [...] the correlation of the VPSS and IPSS with uroflowmetry parameters. METHODS: Men with LUTS were requested to complete the IPSS and VPSS, consisting of pictograms to evaluate urinary frequency, nocturia, force of the stream and quality of life. The maximum (Qmax) and average urinary flow rate (Qave), voided volume (VV) and post-void residual (PVR) urine volumes were measured. Statistical analysis was performed using the Mann-Whitney and Spearman's tests. RESULTS: The study included 93 men (mean age 64 years, range 33 -85), with VV >150 ml in 66 (71%) and 150 ml there were significant negative correlations between the IPSS and Qmax (r=-0.30, p=0.016), the IPSS and Qave (r=-0.29, p=0.018), the VPSS and Qmax (r=-0.38, p

C F, Heyns; C L E, van der Walt; A E, Groeneveld.

2012-04-01

85

Correlations of temperament types, intensity of crisis at midlife with scores on a death scale.  

Science.gov (United States)

331 subjects completed the Keirsey-Bates Temperament Sorter and Dickstein's Death Scale and responded to an intensity of midlife crisis probe. Using a Pearson product-moment coefficient, weak but significant correlations were found for the introvert-sensor-thinker-judger temperament type on the Think and Anxiety subscales and the Think subscale for introvert-sensor-thinker-judger (ISTJ) temperament type. PMID:1924616

Waskel, S A; Coleman, J

1991-06-01

86

Big Macs and Eigenfactor Scores: Don't Let Correlation Coefficients Fool You  

OpenAIRE

The Eigenfactor Metrics provide an alternative way of evaluating scholarly journals based on an iterative ranking procedure analogous to Google's PageRank algorithm. These metrics have recently been adopted by Thomson-Reuters and are listed alongside the Impact Factor in the Journal Citation Reports. But do these metrics differ sufficiently so as to be a useful addition to the bibliometric toolbox? Davis (2008) has argued otherwise, based on his finding of a 0.95 correlation...

West, Jevin; Bergstrom, Theodore; Bergstrom, Carl

2009-01-01

87

The effect of recent trauma on serum complement activation and serum C3 levels correlated with the injury severity score  

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Full Text Available PURPOSE: The objective of this prospective pilot study was to estimate serum C3 levels and complement activation within 12 hours of injury and to correlate them with abbreviated injury score (AIS so as to predict the outcome of injury in terms of mortality or sepsis. METHODS: The test group (n=30 of patients with < 12 hours of injury were assessed by the AIS-80 and compared with a control group (n=10. Serum C3 levels were estimated by the single radial immunodiffusion technique and complement activation by both two-dimensional and counter immuno-electrophoresis. Statistical analysis was performed using the correlation regression analysis and the minimum discrimination information statistics (MDIS analysis. RESULTS: Serum C3 levels were not reduced in patients with injury severity score (ISS < 12 (n=7. There was a statistically significant difference of serum C3 levels in patients with ISS between 12 and 29 (n=15 and in patients with ISS more than 29 (n=9. Complement activation also correlated well with ISS (p <0.05. Complement activation and serum C3 levels were found to influence subsequent development of septic complications in the post injury period, being significantly lower in patients who developed septic complications. Complement alterations in trauma patients were a direct result of the trauma since they were not seen in patients undergoing surgery. CONCLUSIONS: ISS is a good prognosticator of outcome of trauma and serum C3 levels and complement activation are good predictors for mortality and development of septic complications in recently injured patients. These may prove to be effective parameters in the management of the patients with injury.

Sharma D

2004-01-01

88

The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system and the EORTC quality of life questionnaires  

International Nuclear Information System (INIS)

Background and purpose: Morbidity is an important issue in cancer research. The observer-based toxicity scoring system used by DAHANCA (the Danish head and neck cancer study group) has proved itself sensitive to differences in toxicity in a large randomised study, but like other toxicity scoring systems it has not been formally validated. Conversely, the EORTC quality of life questionnaire (QLQ) has been validated as a tool for collecting information about the consequences of disease and treatment on the well being of cancer patients. The purpose of this study was to examine the relationship between the two methods of side effect recording. Patients and methods: One hundred and sixteen recurrence free patients with laryngeal (n=44), pharyngeal (n=34) and oral cavity (n=38) cancer attending follow-up after radiotherapy (n=83) or surgery (n=33) completed EORTC C30, the core questionnaire concerning general symptoms and function and EORTC H and N35 the head and neck specific questionnaire. The attending physicians in the follow-up clinic evaluated and recorded DAHANCA toxicity scores on the same patients. Results: The DAHANCA toxicity scoring system and the EORTC QLQ correlated with several clinical endpoints. The conceptually similar endpoints of the two methods correlated significantly. The objective endpoints of the DAHANCA scoring system were only correlated with quality of life endpoints to a very low degree. The DAHANCA toxicity scores had a low sensitivity (0.48-0icity scores had a low sensitivity (0.48-0.74) in detecting equivalent subjective complaints from the questionnaires and the observer-based scoring system severely underestimated patient complaints. A specific patient group where the DAHANCA score had a higher tendency to fail could not be detected. Conclusion: The DAHANCA toxicity score is an effective instrument in assessing objective treatment induced toxicity in head and neck cancer patients but insensitive and non-specific with regard to patient assessed subjective endpoints. This weakness seems inherent in an observer-based scoring system, and will probably also apply to newer ones like CTCAE 3.0

89

Correlation of volumetric mismatch and mismatch of Alberta Stroke program Early CT scores on CT perfusion maps  

International Nuclear Information System (INIS)

We aimed to determine if volumetric mismatch between tissue at risk and tissue destined to infarct on computed tomography perfusion (CTP) can be described by the mismatch of Alberta Stroke Program Early CT Score (ASPECTS). Forty patients with nonlacunar middle cerebral artery infarct 6 s and <2.0 mL per 100 g, respectively. Two other raters assigned ASPECTS to the same MTT and CBV maps while blinded to the volumetric data. Volumetric mismatch was deemed present if ?20%. ASPECTS mismatch (=CBV ASPECTS - MTT ASPECTS) was deemed present if ?1. Correlation between the two types of mismatches was assessed by Spearman's coefficient (?). ROC curve analyses were performed to determine the optimal ASPECTS mismatch cut point for volumetric mismatch ?20%, ?50%, ?100%, and ?150%. Median volumetric mismatch was 130% (range 10.9-2,031%) with 31 (77.5%) being ?20%. Median ASPECTS mismatch was 2 (range 0-6) with 26 (65%) being ?1. ASPECTS mismatch correlated strongly with volumetric mismatch with ? = 0.763 [95% CI 0.585-0.870], p < 0.0001. Sensitivity and specificity for volumetric mismatch ?20% was 83.9% [95% CI 65.5-93.5] and 100% [95% CI 65.9-100], respectively, using ASPECTS mismatch ?1. Volumetric mismatch ?50%, ?100%, and ?150% were optimally identified using ASPECed using ASPECTS mismatch ?1, ?2, and ?2, respectively. On CTP, ASPECTS mismatch showed strong correlation to volumetric mismatch. ASPECTS mismatch ?1 was the optimal cut point for volumetric mismatch ?20%. (orig.)

90

The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system      and the EORTC quality of life questionnaires  

DEFF Research Database (Denmark)

BACKGROUND AND PURPOSE: Morbidity is an important issue in cancer       research. The observer-based toxicity scoring system used by DAHANCA (the       Danish head and neck cancer study group) has proved itself sensitive to       differences in toxicity in a large randomised study, but like other       toxicity scoring systems it has not been formally validated. Conversely,       the EORTC quality of life questionnaire (QLQ) has been validated as a tool       for collecting information about the consequences of disease and treatment       on the well being of cancer patients. The purpose of this study was to       examine the relationship between the two methods of side effect recording.       PATIENTS AND METHODS: One hundred and sixteen recurrence free patients       with laryngeal (n=44), pharyngeal (n=34) and oral cavity (n=38) cancer       attending follow-up after radiotherapy (n=83) or surgery (n=33) completed       EORTC C30, the core questionnaire concerning general symptoms and function       and EORTC H&N35 the head and neck specific questionnaire. The attending       physicians in the follow-up clinic evaluated and recorded DAHANCA toxicity       scores on the same patients. RESULTS: The DAHANCA toxicity scoring system       and the EORTC QLQ correlated with several clinical endpoints. The       conceptually similar endpoints of the two methods correlated       significantly. The objective endpoints of the DAHANCA scoring system were       only correlated with quality of life endpoints to a very low degree. The       DAHANCA toxicity scores had a low sensitivity (0.48-0.74) in detecting       equivalent subjective complaints from the questionnaires and the       observer-based scoring system severely underestimated patient complaints.       A specific patient group where the DAHANCA score had a higher tendency to       fail could not be detected. CONCLUSION: The DAHANCA toxicity score is an       effective instrument in assessing objective treatment induced toxicity in       head and neck cancer patients but insensitive and non-specific with regard       to patient assessed subjective endpoints. This weakness seems inherent in       an observer-based scoring system, and will probably also apply to newer       ones like CTCAE 3.0

Jensen, Kenneth; Jensen, Anders Bonde

2006-01-01

91

Prostate Volumes Derived From MRI and Volume-Adjusted Serum Prostate-Specific Antigen: Correlation With Gleason Score of Prostate Cancer  

Science.gov (United States)

OBJECTIVE The purpose of this article is to study relationships between MRI-based prostate volume and volume-adjusted serum prostate-specific antigen (PSA) concentration estimates and prostate cancer Gleason score. MATERIALS AND METHODS The study included 61 patients with prostate cancer (average age, 63.3 years; range 52–75 years) who underwent MRI before prostatectomy. A semiautomated and MRI-based technique was used to estimate total and central gland prostate volumes, central gland volume fraction (central gland volume divided by total prostate volume), PSA density (PSAD; PSA divided by total prostate volume), and PSAD for the central gland (PSA divided by central gland volume). These MRI-based volume and volume-adjusted PSA estimates were compared with prostatectomy specimen weight and Gleason score by using Pearson (r) or Spearman (?) correlation coefficients. RESULTS The estimated total prostate volume showed a high correlation with reference standard volume (r = 0.94). Of the 61 patients, eight (13.1%) had a Gleason score of 6, 40 (65.6%) had a Gleason score of 7, seven (11.5%) had a Gleason score of 8, and six (9.8%) had a Gleason score of 9 for prostate cancer. The Gleason score was significantly correlated with central gland volume fraction (? = ?0.42; p = 0.0007), PSAD (? = 0.46; p = 0.0002), and PSAD for the central gland (? = 0.55; p = 0.00001). CONCLUSION Central gland volume fraction, PSAD, and PSAD for the central gland estimated from MRI examinations show a modest but significant correlation with Gleason score and have the potential to contribute to personalized risk assessment for significant prostate cancer. PMID:24147475

Karademir, Ibrahim; Shen, Dinggang; Peng, Yahui; Liao, Shu; Jiang, Yulei; Yousuf, Ambereen; Karczmar, Gregory; Sammet, Steffen; Wang, Shiyang; Medved, Milica; Antic, Tatjana; Eggener, Scott; Oto, Aytekin

2015-01-01

92

Biochemical Indices and Sensory Scores of Kunu-zaki Beverages Produced from Sprouted and Unsprouted Guinea Corn and Their Correlations  

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Full Text Available Kunu-zaki beverage is a popular cereal-grain based non-alcoholic drink traditionally produced from sprouted cereal grains like sorghum, millet, maize or their mixtures. Unsprouted grains can also be used, thereby saving time spent during sprouting without compromising sensory property. The present study sought to investigate, in comparative terms, the biochemical indices and sensory scores of Kunu-zaki beverages produced from Sprouted Guinea Corn (SGC and Unsprouted Guinea Corn (USGC as well as establishing correlation between these parameters. Production of Kunu-zaki beverages from USGC and SGC was carried out using standard procedures. Samples of the beverages were analyzed for glucose, protein and hydrogen ion concentrations in concurrence with sensory evaluation scores. The results indicated that the Kunu-zaki beverages produced were of comparable (p>0.05 acidity values. Protein and glucose concentrations of Kunu-zaki beverage produced from SGC were significantly higher (p Kunu-zaki beverage produced from SGC gave: [protein] = 10.6±2.62 g L-1 and [glucose] = 500.0±4.90 mg dL-1, whereas beverage produced from USGC gave [protein] = 3.0 g L-1 and [glucose] = 335.3±2.8 mg dL-1. Sensory attributes of the beverages were not significantly different (p>0.05. The pH, mouthfeel, protein and glucose contents of the beverages had strong positive effects on their tastes. The protein content of Kunu-Zaki beverage produced from SGC had marginal effect on its taste. Although the levels of some biochemical parameters were reduced when Kunu-zaki beverage was produced from USGC, it did not affect its sensory property.

C.O. Ibegbulem

2014-01-01

93

Lack of a correlation between micronucleus scores in cytokinesis - blocked lymphocytes and cancer patient response to radiotherapy  

International Nuclear Information System (INIS)

In the present study, we have used a retrospective approach in order to investigate a range of radiosensitivities measured by micronucleus (Mn) assay in lymphocytes of head and neck, and cervix cancer patients. There were treatment failures and tumor free patients in both groups. The aim therefore was to establish the possible role of MN scores in identifying these different responses. Peripheral blood samples were collected from 15 patients for head and neck cancer group, and from 16 patients for cervix group. The samples were irradiated with 3 Gy of Co-60 gamma irradiation. Micronucleus values which determine the cellular radiosensitivity ranged between 0.03 and 0.39 with the average value of 0.23 for head and neck cancer patients and ranged between 0.05 and 0.48 with the average value of 0.25. Statistically, there was no difference between radiosensitivity of two patients groups (p=0.33). In cervix cancer group, there were four treatment failure patients and there were six treatment failure patients in head and neck cancer group. MN frequencies of all the failure patients generated more micronuclei following in vitro test irradiation and were above the average sensitivity value of 0.25. The results in the present paper provide an evidence that although we investigated two different cancer groups, the quantitative similarities in the radiosensitivity range measured by MN assay exist. However, within the radiosensitivity range of each group, there was lack of a corree of each group, there was lack of a correlation between MN scores and patient response. It could be concluded that MN test applied to lymphocytes does not have a predictive value in patient prognosis. (authors)

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Comparisons of bone mass measurements on various skeletal sites including quantitative ultrasonography of the calcaneus for assessing age-related losses, their correlations, and diagnostic agreement using the Japanese and WHO criteria for osteoporosis  

International Nuclear Information System (INIS)

The aim of this study was to compare age-related bone losses and correlations among several bone mass measurements and to evaluate diagnostic agreement among them using the Japanese and World Health Organization (WHO) criteria for osteoporosis. A total of 846 women (mean±standard deviation (SD): age 54±9 years) were evaluated. Bone mineral densities of the lumbar spine, femoral neck, and calcaneus were measured by dual X-ray absorptiometry and distal radius by peripheral computed tomography. Quantitative ultrasonography (QUS) parameters of the calcaneus were also measured. The age-related bone losses after 50 years of age and correlations among bone mass results were evaluated using linear regression analysis. Diagnostic agreement was evaluated by kappa statistics. The annual losses ranged from 1.0% to 1.6%. The correlation coefficients ranged from 0.54 to 0.78. The kappa scores ranged from 0.52 to 0.30 for all subjects using the Japanese criteria and from 0.38 to 0.15 using the WHO criteria. Bone mass measurements including QUS on various skeletal sites documented age-related changes similarly, and their bone masses correlated moderately. The diagnostic agreements among them were fair to poor. To screen out women with a risk of osteoporosis, it is important to choose which technique to use and which skeletal site to measure. (author)

95

Modified Chrispin-Norman score: correlation with peak exercise capacity and efficiency of ventilation in children with cystic fibrosis.  

Science.gov (United States)

The modified Chrispin-Norman radiography score (CNS) is used in evaluation of radiographic changes in children with cystic fibrosis (CF). We evaluated the correlation of modified CNS with peak exercise capacity (Wpeak) and ventilatory efficiency (reflected by breathing reserve index-BRI) during progressive cardiopulmonary exercise testing (CPET). Thirty-six children aged 8-17 years were stratified according to their CNS into 3 groups: mild (15). CPET was performed on a cycle ergometer. Lung function tests included spirometry and whole-body plethysmography. Patients with higher CNS had lower FEV1 (p BRI at the anaerobic threshold and at Wpeak was elevated in patients with the highest CNS values (p BRI (R = -0.419; p = .011). Stepwise multiple linear regression showed that RV/TLC was the best predictor of Wpeak/pred (%; B = -0.165; ? = -0.494; R2 = .244; p = .002). Children with CF who have high modified CNS exhibit decreased exercise tolerance and ventilatory inefficacy during progressive effort. PMID:25111160

Sovtic, Aleksandar; Minic, Predrag; Kosutic, Jovan; Markovic-Sovtic, Gordana; Gajic, Milan

2014-08-01

96

Performance of an Automated Polysomnography Scoring System Versus Computer-Assisted Manual Scoring  

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Study Objectives: Manual scoring of polysomnograms (PSG) is labor intensive and has considerable variance between scorers. Automation of scoring could reduce cost and improve reproducibility. The purpose of this study was to compare a new automated scoring system (YST-Limited, Winnipeg, Canada) with computer-assisted manual scoring. Design: Technical assessment. Setting: Five academic medical centers. Participants: N/A. Interventions: N/A. Measurements and Results: Seventy PSG files were selected at University of Pennsylvania (Penn) and distributed to five US academic sleep centers. Two blinded technologists from each center scored each file. Automatic scoring was performed at Penn by a YST Limited technician using a laptop containing the software. Variables examined were sleep stages, arousals, and apnea-hypopnea index (AHI) using three methods of identifying hypopneas. Automatic scores were not edited and were compared to the average scores of the 10 technologists. Intraclass correlation coefficient (ICC) was obtained for the 70 pairs and compared to across-sites ICCs for manually scored results. ICCs for automatic versus manual scoring were > 0.8 for total sleep time, stage N2, and nonrapid eye movement arousals and > 0.9 for AHI scored by primary and secondary American Academy of Sleep Medicine criteria. ICCs for other variables were not as high but were comparable to the across-site ICCs for manually scored results. Conclusion: The automatic system yielded results that were similar to those obtained by experienced technologists. Very good ICCs were obtained for many primary PSG outcome measures. This automated scoring software, particularly if supplemented with manual editing, may increase laboratory efficiency and standardize PSG scoring results within and across sleep centers. Citation: Malhotra A; Younes M; Kuna ST; Benca R; Kushida CA; Walsh J; Hanlon A; Staley B; Pack AI; Pien GW. Performance of an automated polysomnography scoring system versus computer-assisted manual scoring. SLEEP 2013;36(4):573-582. PMID:23565003

Malhotra, Atul; Younes, Magdy; Kuna, Samuel T.; Benca, Ruth; Kushida, Clete A.; Walsh, James; Hanlon, Alexandra; Staley, Bethany; Pack, Allan I.; Pien, Grace W.

2013-01-01

97

Correlation between serum ferritin levels and attention-deficit/hyperactivity disorder symptom scores in children based on the Abbreviated Conners Teachers Rating Scale  

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Full Text Available Background Dopamine deficiency is thought to be one of the factors causing attention-deficit /hyperactivity disorder (ADHD in children. Iron contributes to the regulation of dopamine neurotransmitter activity, thus, iron deficiency has been associated with ADHD. Several studies have been conducted in other countries to assess for a correlation between serum ferritin levels and ADHD symptom scores, but with varied results. Objective To examine the relationship between iron deficiency and ADHD symptoms, in particular the correlation between serum ferritin levels and Abbreviated Conners Teachers Rrating Scale (ACTRS scores in children with ADHD. Methods This cross-sectional study was performed in children aged 5-12 years who were newly diagnosed with ADHD. Subjects were recruited from the Klinik Anakku Kelapa Gading, the Neurology Outpatient Clinic, the Growth and Development-Social Pediatrics Clinic, and the Integrated Child Clinic of Cipto Mangunkusumo Hospital. ADHD diagnoses were established using Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSMm-IV. Subjects’ parents and teachers were asked to complete the ACTRS instrument sheet. Venous blood specimens were obtained for peripheral blood and serum ferritin level tests. Results Of the 33 subjects recruited, 23 were male. Subjects’ ages ranged from 5-12 years, with a median age of onset of 4 (range 2-10 years. The combined type of ADHD (with inattention and hyperactivity-impulsivity was more commonly found (20/33 in our subjects. The mean serum ferritin was 51.31 (SD 27.7 ng/mL. Using 20 ng/mL as the serum ferritin cutoff value, 5/33 subjects were considered to be iron deficient. Median ACTRS score by parents and teachers were 15 and 15, respectively. Higher scores were found in the combined type subject group than in the inattention type subject group. Mmedian serum ferritin levels of the two ADHD type groups were similar. ACTRS scores of parents and teachers tended to be higher in the iron-deficient group (16 and 16, respectively than in the normal serum iron group (14.5 and 12.5, respectively. Serum ferritin level showed no correlation (r=-0.243; P=0.086 to the parents’ ACTRS score, and no correlation (r=-.057; P=0.377 to the teachers’ ACTRrS score. Conclusion Serum ferritin level showed no correlation to ACTRS scores of parents and teachers, respectively. However, the median ACTRS score was higher in the iron-deficiency group than in the normal iron status group, suggesting that there may be a qualitative relationship between iron deficiency and ADHD symptoms.

Intan Alita Putri Tumbelaka

2014-10-01

98

Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler memory scale-revised logical/verbal memory score for healthy subjects  

International Nuclear Information System (INIS)

Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM). T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A P value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant. Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal, T value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal, T value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found. To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score fy correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing. (orig.)

99

Correlation of CT angiographic pulmonary artery obstruction scores with right ventricular dysfunction and clinical outcome in patients with acute pulmonary embolism  

International Nuclear Information System (INIS)

Objective: To correlate CTA pulmonary artery obstruction scores (OS) with right ventricular dysfunction (RVD) and clinical outcome in patients with acute pulmonary embolism (PE). Materials and methods: In a prospective study of 50 patients (66 ± 12.9 years) with PE pulmonary artery OS (Qanadli, Mastora, and Mastora central) were assessed by two radiologists. To assess RVD all patients underwent echocardiography within 24 h. Furthermore, RVD on CT was assessed by calculating the right ventricular/left ventricular (RV/LV) diameter ratios on transverse (RV/LVtrans) and four-chamber views (RV/LV4ch) as well as the RV/LV volume ratio (RV/LVvol). OS were correlated with RVD and the occurrence of adverse clinical outcomes (defined as death, need for intensive care treatment, or cardiac insufficiency ?NYHA III). Results: Mean Mastora, Qanadli, and Mastora central OS were 26.4 ± 17.7, 12.6 ± 9.9 and 7.5 ± 9, respectively. Echocardiography demonstrated moderate and severe RVD in 10 and 5 patients, respectively. Patients with moderate and severe RVD showed significantly higher Mastora central scores than patients without RVD (14 ± 10.8 vs. 5.9 ± 7.8 [p = 0.05]; 17.6 ± 13.2 vs. 5.9 ± 7.8 [p = 0.038]). A relevant correlation (i.e. r ? 0.6) between OS and CT parameters for RVD were only found for the Mastora score and the Mastora central score (RV/LV4ch: r = 0.61 and 0.68, RV/LVvol: r = 0.61 and 0.6). 18 patients experienced an adverse clinical outcome. None of the OS differed significantly between patients with and without adverse clinical outcome. Conclusion: Pulmonary artery obstruction scores can differentiate between patients with and without RVD. However, in this study, obstruction scores were not correlated to adverse clinical outcome

100

Correlation of CT angiographic pulmonary artery obstruction scores with right ventricular dysfunction and clinical outcome in patients with acute pulmonary embolism  

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Objective: To correlate CTA pulmonary artery obstruction scores (OS) with right ventricular dysfunction (RVD) and clinical outcome in patients with acute pulmonary embolism (PE). Materials and methods: In a prospective study of 50 patients (66 ± 12.9 years) with PE pulmonary artery OS (Qanadli, Mastora, and Mastora central) were assessed by two radiologists. To assess RVD all patients underwent echocardiography within 24 h. Furthermore, RVD on CT was assessed by calculating the right ventricular/left ventricular (RV/LV) diameter ratios on transverse (RV/LVtrans) and four-chamber views (RV/LV4ch) as well as the RV/LV volume ratio (RV/LVvol). OS were correlated with RVD and the occurrence of adverse clinical outcomes (defined as death, need for intensive care treatment, or cardiac insufficiency ?NYHA III). Results: Mean Mastora, Qanadli, and Mastora central OS were 26.4 ± 17.7, 12.6 ± 9.9 and 7.5 ± 9, respectively. Echocardiography demonstrated moderate and severe RVD in 10 and 5 patients, respectively. Patients with moderate and severe RVD showed significantly higher Mastora central scores than patients without RVD (14 ± 10.8 vs. 5.9 ± 7.8 [p = 0.05]; 17.6 ± 13.2 vs. 5.9 ± 7.8 [p = 0.038]). A relevant correlation (i.e. r ? 0.6) between OS and CT parameters for RVD were only found for the Mastora score and the Mastora central score (RV/LV4ch: r = 0.61 and 0.68, RV/LVvol: r = 0.61 and 0.6). 18 patients experienced an adverse clinical outcome. None of the OS differed significantly between patients with and without adverse clinical outcome. Conclusion: Pulmonary artery obstruction scores can differentiate between patients with and without RVD. However, in this study, obstruction scores were not correlated to adverse clinical outcome.

Apfaltrer, P., E-mail: paul.apfaltrer@medma.uni-heidelberg.de [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Henzler, T.; Meyer, M. [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Roeger, S.; Haghi, D.; Gruettner, J.; Süselbeck, T. [Department of Internal Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Wilson, R.B.; Schoepf, U.J. [Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Drive, MSC 226, Charleston, SC 29401 (United States); Schoenberg, S.O.; Fink, C. [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany)

2012-10-15

101

Correlation of the modified Glasgow coma scale and Ramsay sedation scale scores with bispectral index monitoring in unconscious critically ill patients  

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Full Text Available Objective: Monitoring critically ill patients with a decreased level of consciousness is challenging. It is suggested that bispectral index monitoring (BIS may be useful in the assessment of neurologic functions for critical care patients because simplicity is its essence. The aim of this randomised, prospective study was to assess the correlation of BIS with the Glasgow coma score modified by Cook and Palma (GCSC and Ramsay sedation scale (RSS for the measurement of neurologic status in critically ill patients. Material and Methods: Thirty-eight patients ranged from 15 to 65 years of age were evaluated for level of consciousness using BIS, GCSC and RSS in addition to standard intensive care monitorization. Spearman’s correlation coefficient was used to correlate the BIS scores with clinical scales. Results: BIS values correlated significantly with RSS (r= -0,388; p= 0,016 and GCSC (r= 0,629; p= 0,001. GCSC was significantly correlated with RSS (r= -0,518; p= 0,001. Conclusion: It was concluded that BIS is suitable for monitoring the neurologic status in unsedated critically ill patients. BIS was well correlated with the clinical assessment based on various scores.

Elif Bombac?

2005-01-01

102

Empirical Correlates of Low Scores on MMPI-2/MMPI-2-RF Restructured Clinical Scales in a Sample of University Students  

Science.gov (United States)

In the present study, the authors explored the meaning of low scores on the MMPI-2/MMPI-2-RF Restructured Clinical (RC) scales. Using responses of a sample of university students (N = 811), the authors examined whether low (T less than 39), within-normal-limits (T = 39-64), and high (T greater than 65) score levels on the RC scales are…

Avdeyeva, Tatyana V.; Tellegen, Auke; Ben-Porath, Yossef S.

2012-01-01

103

Could near-infrared Raman spectroscopy be correlated with the METAVIR scores in liver lesions induced by hepatitis C virus?  

Science.gov (United States)

The liver is responsible for several basic functions in human body how the syntheses of the most main proteins and degradation process of toxins, drugs and alcohols. In present days, the viral hepatitis C is one of the highest causes of chronic hepatic illness worldwide, affecting around 3% of the world population. The liver biopsy is considered the gold standard for diagnosing hepatic fibrosis; however, the biopsies may be questioned because of potential sampling error, morbidity, possible mortality and relatively high costs. Spectroscopy techniques such as Raman spectroscopy have been used for diagnosis of human tissues, with favorable results. Raman spectroscopy has been employed to distinguish normal from hepatic lesions through spectral features mainly of proteins, nucleic acids and lipids. In this study, eleven patients with diagnoses of chronic hepatitis C underwent hepatic biopsies having two hepatic fragments collected: one was scored through METAVIR system and the other one was submitted to near-infrared Raman spectroscopy using a dispersive spectrometer (830 nm wavelength, 300 mW laser power and 20 s exposure time). Five spectra were collected in each fragment and submitted to Principal Components Analysis (PCA). Results showed a good correlation between the Raman spectroscopy features and the stage of hepatic fibrosis and inflammation. PCA showed that samples with higher degree of fibrosis presented higher amount of protein features (collagen), whereas samples of higher degree of inflammation presented higher features of hemoglobin, in accordance to the expected evolution of the chronic hepatitis. It has been found an important biomarker for the beginning of hepatic lesion (quinone) with a spectral feature at 1595 cm-1.

Gaggini, Marcio Cesar Reino; Navarro, Ricardo Scarparo; Stefanini, Aline Reis; Sano, Rubens Sato; Silveira, Landulfo

2013-03-01

104

CORRELATION OF PEMPHIGUS VULGARIS ANTIBODY TITERS BY INDIRECT IMMUNOFLUORESCENCE WITH ACTIVITY OF DISEASE BASED ON PEMPHIGUS AREA AND ACTIVITY SCORE (PAAS  

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Full Text Available Indirect immunofluorescence (IIF has been used to identify and measure autoantibody levels in pemphigus vulgaris but data about relationship between clinical severity of disease and antibody titers by IIF have been conflicting. We conducted this cross-sectional study to correlate the severity of oral and/or cutaneous involvement in patients with pemphigus vulgaris based on Pemphigus Area and Activity Score with IIF titers. Sixty-one new pemphigus vulgaris patients were included in this study. Human prepuce was used as substrate for IIF and assessment of disease severity was based on Pemphigus Area and Activity Score. The mean±SD age was 44.04±30.46 years, with a range of 18 to 79 years. IIF was positive in 56 (91.8% patients. There was a significant relationship between total disease score and IIF titers ((P<0.001. Also a significant relationship was found between skin score (P=0.04 and mucosal score (P=0.04 with IIF titers. Our results show that there is a significant relationship between disease activity based on Pemphigus Area and Activity Score and antibody titers by IIF. Further studies are recommended to determine the usefulness of this technique for monitoring disease.

H. Mortazavi

2008-06-01

105

Correlation between Bhalla score and spirometry in children and adolescents with Cystic Fibrosis / Correlação entre escore de Bhalla e espirometria em crianças e adolescentes com fibrose cística  

Scientific Electronic Library Online (English)

Full Text Available Objetivo: correlacionar os achados da tomografia computadorizada de alta resolução (TCAR) do tórax, com base no escore de Bhalla, com os dados clínicos e a espirometria em crianças e adolescentes com fibrose cística (FC), além de estudar a concordância entre dois médicos radiologistas para o escor [...] e de Bhalla e suas categorias. Métodos: foram avaliados os prontuários e os exames de 23 pacientes do ambulatório. Os itens avaliados foram idade, peso, altura, escore Z altura/idade, escore Z peso/ idade, índice de massa corpórea (IMC), saturação de O2, espirometria e escore de Bhalla. Resultados: os pacientes avaliados tinham média de idade de 17,4±5,7 anos, sendo 15 do sexo feminino e 8 do sexo masculino. Houve boa correlação entre o escore de Bhalla e a espirometria (CVF-r = 0,718, p 70% já apresentavam alterações na nota final do escore de Bhalla. Na análise da concordância entre os examinadores, foi encontrado coeficiente kappa de 0,81 (p Abstract in english Objective: to correlate the findings of high resolution computed tomography of the chest based on the Bhalla score with the clinical data and spirometry in children and adolescents with cystic fibrosis, and to study the concordance between two radiologists for the Bhalla score and its categories. [...] Methods: we evaluated the medical records of 23 patients from the outpatient clinic. The items evaluated included age, weight, height, height/age Z-score, weight/age Z-score, body mass index (BMI), O2 saturation, spirometry and Bhalla score. Results: the patients had a mean age of 17.4 years ± 5.7 years, with fifteen females and eight males. There was good correlation between Bhalla score and spirometry (FVC-r =0.718, p 70% already had changes in their final Bhalla score. In the analysis of the concordance between the examiners a Kappa coefficient of 0.81 (p

Flavia Fajardo Linhares, Pereira; Cassio da Cunha, Ibiapina; Cristina Gonçalves, Alvim; Paulo Augusto Moreira, Camargos; Reginaldo, Figueiredo; Jesiana Ferreira, Pedrosa.

2014-06-01

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Estimativas de herdabilidade e correlações para escores visuais, peso e altura ao sobreano em rebanhos da raça Nelore Estimates of heritabilities and correlations for visual scores, weight and height at 550 days of age in Nelore cattle herds  

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Full Text Available Os objetivos neste trabalho foram avaliar as relações entre os escores visuais de estrutura corporal, precocidade e musculosidade ao sobreano (aproximadamente 550 dias de idade com características de crescimento para verificar as possibilidades de utilizar essas características como critérios de seleção. Foram obtidas estimativas dos componentes de covariâncias por máxima verossimilhança restrita empregando-se um modelo animal com o efeito fixo de grupo contemporâneo e a idade como covariável (efeitos linear e quadrático. Os grupos contemporâneos foram definidos pelas variáveis: sexo; ano, estação e fazenda de nascimento; e fazenda e grupo de manejo aos 120, 210, 365 e 550 dias de idade. Foram utilizadas 1.367 observações de estrutura corporal, precocidade e musculosidade. As estimativas de herdabilidade foram de 0,24 ± 0,09 para estrutura corporal; 0,63 ± 0,12 para precocidade e 0,48 ± 0,11 para musculosidade, e as estimativas de correlações genéticas entre os escores foram 0,49 entre estrutura corporal e precocidade; 0,63 entre estrutura corporal e musculosidade; e 0,90 entre precocidade e musculosidade. As correlações genéticas entre os escores de estrutura corporal, precocidade e musculosidade, e o peso ao sobreano foram todas positivas (0,83; 0,42 e 0,50, respectivamente, enquanto as estimativas de correlações genéticas entre altura de posterior e os escores de estrutura corporal, precocidade e musculosidade, respectivamente, foram 0,57, -0,29 e -0,33. As características estrutura corporal, precocidade e musculosidade ao sobreano apresentaram variação genética aditiva de moderada a alta. As correlações genéticas dos escores com altura do posterior indicam que a seleção de animais mais altos, ainda que indireta, pode ocasionar aumento da estrutura corporal média dos animais, que poderão ser menos precoces e menos musculosos ao sobreano. A seleção para os escores visuais, principalmente para estrutura corporal, deve promover aumento no peso ao sobreano dos animais.The objectives of this study were to evaluate the associations between visual scores of body structure, precocity and muscling at 550 days of age and growing traits, and verify the possibilities of applying these traits as selection criteria. (Covariance components were estimated by restricted maximum likelihood, employing an animal model with fixed effects of contemporary group and age as a covariate (linear and quadratic effects. Contemporary groups were defined by variables: sex; year, season and herd of birth; herd and management group at 120, 210, 365 and 550 days of age. Scores from 1,367 animals for body structure, precocity and muscling were evaluated. Heritability estimates for the visual scores were 0.24 ± 0.09 for body structure, 0.63 ± 0.12 for precocity and 0.48 ± 0.11 for muscling. Genetic correlations estimates among the scores were 0.49 for body structure and precocity, 0.63 between body structure and muscling, 0.90 between precocity and muscling. The genetic correlation estimates among the scores of body structure, precocity and muscling and weight at 550 days were all positive (0.83, 0.42 and 0.50, respectively, while the genetic correlation estimates between hip height and body structure, precocity and muscling were 0,57, -0,29 and -0,33, respectively. Scores for body structure, precocity and muscling at 550 days of age presented moderate-to-large additive genetic variability. The genetic correlation estimates between visual scores and hip height indicated that the selection of taller animals, even though indirectly, can increase the body structure of animals and decrease precocity and muscling at 550 days. Selection for visual scores, especially body structure, should increase animal weight at 550 days.

William Koury Filho

2009-12-01

107

Formation of translational risk score based on correlation coefficients as an alternative to Cox regression models for predicting outcome in patients with NSCLC  

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Full Text Available Abstract Background Personalised cancer therapy, such as that used for bronchial carcinoma (BC, requires treatment to be adjusted to the patient's status. Individual risk for progression is estimated from clinical and molecular-biological data using translational score systems. Additional molecular information can improve outcome prediction depending on the marker used and the applied algorithm. Two models, one based on regressions and the other on correlations, were used to investigate the effect of combining various items of prognostic information to produce a comprehensive score. This was carried out using correlation coefficients, with options concerning a more plausible selection of variables for modelling, and this is considered better than classical regression analysis. Methods Clinical data concerning 63 BC patients were used to investigate the expression pattern of five tumour-associated proteins. Significant impact on survival was determined using log-rank tests. Significant variables were integrated into a Cox regression model and a new variable called integrative score of individual risk (ISIR, based on Spearman's correlations, was obtained. Results High tumour stage (TNM was predictive for poor survival, while CD68 and Gas6 protein expression correlated with a favourable outcome. Cox regression model analysis predicted outcome more accurately than using each variable in isolation, and correctly classified 84% of patients as having a clear risk status. Calculation of the integrated score for an individual risk (ISIR, considering tumour size (T, lymph node status (N, metastasis (M, Gas6 and CD68 identified 82% of patients as having a clear risk status. Conclusion Combining protein expression analysis of CD68 and GAS6 with T, N and M, using Cox regression or ISIR, improves prediction. Considering the increasing number of molecular markers, subsequent studies will be required to validate translational algorithms for the prognostic potential to select variables with a high prognostic power; the use of correlations offers improved prediction.

ElAidi Tina

2011-07-01

108

Could the bone mineral density (T-score) be correlated with the Raman spectral features of keratin from women's nails and be used to predict osteoporosis?  

Science.gov (United States)

Osteoporosis is a disease with great importance in current public health due to the associated risk of fracture; therefore, a rapid and accurate diagnosis becomes increasingly important. Recent literature has described a possible relationship between the changes in the organic phase of bone and the changes in nail keratin measured through Raman spectroscopy, aiming at the development of a standard for measuring bone quality and fracture risk both rapid and accurately. This work evaluated the correlation between the bone mineral density (BMD) scores of women with and without osteoporotic disease with the changes in the Raman spectra of the nail keratin, by assessing the intensity of the peak at 510 cm(-1) (S-S bridge) and the scores of principal component analysis (PCA), correlated with the values of BMD measured at the lumbar and hip. Raman spectra of ex vivo fingernails of 213 women were obtained by means of a dispersive Raman spectrometer (830 nm, 300 mW, in the spectral range between 400 and 1,800 cm(-1)). Peak intensities at ?510 cm(-1) (assigned to the keratin S-S bridge) were measured, and the scores of first principal component loading vectors were calculated. Results showed no differences in the mean Raman spectra of nails of groups with and without osteoporosis. No correlation was found between the BMD scores and both the intensities of the 510 cm(-1) peak and the scores of the first four principal component vectors. Results suggest that BMD and fracture risk could not be assessed by the nail keratin features. PMID:25240387

Mussatto, Julio Cesar; Perez, Mauro Coura; de Souza, Renato Aparecido; Pacheco, Marcos Tadeu T; Zângaro, Renato Amaro; Silveira, Landulfo

2015-01-01

109

Correlation of regional distribution and morphological pattern of calcification at CT coronary artery calcium scoring with non-calcified plaque formation and stenosis  

International Nuclear Information System (INIS)

To investigate whether regional calcification patterns at CT coronary artery calcium scoring (CCS) correlate with stenosis and non-calcified plaque formation. We studied 106 patients with quantitative catheter angiography (QCA), CCS, and coronary CT angiography (cCTA). CCS was determined globally and for each artery separately. The morphological pattern of each calcification was classified as calcified nodule, shell-like, or diffuse. cCTA studies were evaluated for non-calcified plaque. The global and regional CCS and the calcification pattern were correlated with stenosis ?50% and non-calcified plaque. A total of 48/106 patients had stenosis ?50% on QCA. There was weak correlation (r = 0.36) of the global CCS with stenosis. Correlation was stronger per vessel (r = 0.55-r = 0.67). Shell-like and diffuse calcifications were significantly (p = 0.0001) more frequently associated with ?50% stenosis and non-calcified plaque (p = 0.04) than calcified nodules. As shown before, the global CCS does not correlate well with stenosis. However, regional calcium distribution and specific patterns of calcification are correlated with stenosis and non-calcified plaque. Thus, the specificity of CT calcium scoring for identifying individuals with obstructive disease could be improved by vessel-based rather than global quantification of calcium and by differentiating specific morphological patterns of calcification. (orig.)

110

Correlation of regional distribution and morphological pattern of calcification at CT coronary artery calcium scoring with non-calcified plaque formation and stenosis  

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To investigate whether regional calcification patterns at CT coronary artery calcium scoring (CCS) correlate with stenosis and non-calcified plaque formation. We studied 106 patients with quantitative catheter angiography (QCA), CCS, and coronary CT angiography (cCTA). CCS was determined globally and for each artery separately. The morphological pattern of each calcification was classified as calcified nodule, shell-like, or diffuse. cCTA studies were evaluated for non-calcified plaque. The global and regional CCS and the calcification pattern were correlated with stenosis {>=}50% and non-calcified plaque. A total of 48/106 patients had stenosis {>=}50% on QCA. There was weak correlation (r = 0.36) of the global CCS with stenosis. Correlation was stronger per vessel (r = 0.55-r = 0.67). Shell-like and diffuse calcifications were significantly (p = 0.0001) more frequently associated with {>=}50% stenosis and non-calcified plaque (p = 0.04) than calcified nodules. As shown before, the global CCS does not correlate well with stenosis. However, regional calcium distribution and specific patterns of calcification are correlated with stenosis and non-calcified plaque. Thus, the specificity of CT calcium scoring for identifying individuals with obstructive disease could be improved by vessel-based rather than global quantification of calcium and by differentiating specific morphological patterns of calcification. (orig.)

Thilo, Christian [Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States); Medical University of South Carolina, Department of Medicine, Division of Cardiology, Charleston, SC (United States); Klinikum Augsburg, Department of Cardiology, Augsburg (Germany); Gebregziabher, Mulugeta [Medical University of South Carolina, Department of Biostatistics, Bioinformatics and Epidemiology, Charleston, SC (United States); Mayer, Florian B.; Costello, Philip [Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States); Zwerner, Peter L.; Schoepf, U.J. [Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States); Medical University of South Carolina, Department of Medicine, Division of Cardiology, Charleston, SC (United States)

2010-04-15

111

Correlation of the modified Glasgow coma scale and Ramsay sedation scale scores with bispectral index monitoring in unconscious critically ill patients  

OpenAIRE

Objective: Monitoring critically ill patients with a decreased level of consciousness is challenging. It is suggested that bispectral index monitoring (BIS) may be useful in the assessment of neurologic functions for critical care patients because simplicity is its essence. The aim of this randomised, prospective study was to assess the correlation of BIS with the Glasgow coma score modified by Cook and Palma (GCSC) and Ramsay sedation scale (RSS) for the measurement of neurologic status in c...

Elif Bombac?; Ay?enur Boztepe; Ay?egül Çizen; Banu Çevik; Serhan Çolako?lu; Tülin Yollu Atakan

2005-01-01

112

Formation of translational risk score based on correlation coefficients as an alternative to Cox regression models for predicting outcome in patients with NSCLC  

OpenAIRE

Abstract Background Personalised cancer therapy, such as that used for bronchial carcinoma (BC), requires treatment to be adjusted to the patient's status. Individual risk for progression is estimated from clinical and molecular-biological data using translational score systems. Additional molecular information can improve outcome prediction depending on the marker used and the applied algorithm. Two models, one based on regressions and the other on correlations, were used to investigate the ...

ElAidi Tina; Willms Arnulf; Fiebeler Anette; Kössler Wolfgang; Klosterhalfen Bernd; Klinge Uwe

2011-01-01

113

The Correlation of Brody High Resolution Computed Tomography Scoring System with Clinical Status and Pulmonary Function Test in Patients with Cystic Fibrosis  

OpenAIRE

Background: To reduce the mortality and morbidity rates of cystic fibrosis (CF) patients, and to have an effective clinical management, it is important to monitor the progression of the disease. The aim of this study was to evaluate the progression of lung disease in CF patients by means of assessing the correlation of the CT scoring system with clinical status and pulmonary function test at the Pediatric Pulmonary Ward of Masih Daneshvari Hospital in 2008. Methods: Pulmonary high resolution ...

Soheila Khalilzadeh; Shahram Kahkouee; Maryam Hassanzad; Nazanin Parsanejad; Nooshin Baghaie; Mohammad Reza Bloorsaz

2011-01-01

114

CORRELATION OF PEMPHIGUS VULGARIS ANTIBODY TITERS BY INDIRECT IMMUNOFLUORESCENCE WITH ACTIVITY OF DISEASE BASED ON PEMPHIGUS AREA AND ACTIVITY SCORE (PAAS)  

OpenAIRE

Indirect immunofluorescence (IIF) has been used to identify and measure autoantibody levels in pemphigus vulgaris but data about relationship between clinical severity of disease and antibody titers by IIF have been conflicting. We conducted this cross-sectional study to correlate the severity of oral and/or cutaneous involvement in patients with pemphigus vulgaris based on Pemphigus Area and Activity Score with IIF titers. Sixty-one new pemphigus vulgaris patients were included in this study...

Mortazavi, H.; Kiavash, K.; Chams-davatchi, N. Esmaili C.

2008-01-01

115

Correlation of the bottom turn technique with the scores attributed in high performance surfing. DOI: http://dx.doi.org/10.5007/1980-0037.2012v14n5p554  

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Full Text Available The surf contests worldwide have presented a high and homogeneous level of performance by the athletes. Thus, the hypothesis that the bottom turn (BT, curve on the base of the wave which is essential to the construction of subsequent maneuvers, might influence the results in high performance competitions. The objective of this study was to quantify the time taken in the execution of the BT by the athletes and correlate it to the scores awarded. The research sample was composed of four contests of the Surfing World Tour. Four heats of each contest were assessed, in a total of sixteen heats studied. The analysis of each BT was performed by using the video split feature available in the Sony Vegas Pro 10.0 software. The statistic analysis was performed with the software SPSS 18.0. The Pearson correlation coefficient was calculated with a significance level of p<0.01. According to the correlations, there was an association between the variables for 87.5% of the cases. Results show that the increase of the curve in the base of the wave (BT can maximize the performance potential of the surfers, suggesting that BT is a fundamental technical aspect in the construction of subsequent maneuvers that suit the judging criteria of this category.

Juarez Vieira Nascimento

2012-09-01

116

Does Council Tax Valuation Band (CTVB correlate with Under-Privileged Area 8 (UPA8 score and could it be a better 'Jarman Index'?  

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Full Text Available Abstract Background Widespread scepticism persists on the use of the Under-Privileged Area (UPA8 score of Jarman in distributing supplementary resources to so-attributed 'deprived' UK general practices. The search for better 'needs' markers continues. Having already shown that Council Tax Valuation Band (CTVB is a predictor of UK GP workload, we compare, here, CTVB of residence of a random sample of patients with their respective 'Jarman' scores. Methods Correlation coefficient is calculated between (i the CTVB of residence of a randomised sample of patients from an English general practice and (ii the UPA8 scores of the relevant enumeration districts in which they live. Results There is a highly significant correlation between the two measures despite modest study size of 478 patients (85% response. Conclusions The proposal that CTVB is a marker of deprivation and of clinical demand should be examined in more detail: it correlates with 'Jarman', which is already used in NHS resource allocation. But unlike 'Jarman', CTVB is simple, objective, and free of the problems of Census data. CTVB, being household-based, can be aggregated at will.

Taylor Gordon

2001-11-01

117

Correlation and discriminant analysis between clinical, endoscopic, thoracic X-ray and bronchoalveolar lavage fluid cytology scores, for staging horses with recurrent airway obstruction (RAO).  

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As recurrent airway obstruction (RAO) is progressive and as medical history is frequently unknown by owners, it's important to suggest a score model to characterize RAO stages for a more accurate diagnosis and treatment. The authors correlated clinical (CS), endoscopic (ES), thoracic X-ray (XRS) and bronchoalveolar lavage fluid (BALFS) scores in horses with RAO, in an attempt to establish relevance of each factor's contribution for the characterization of RAO stages and to suggest a staging method. Thirty horses with RAO and ten healthy controls were studied. Pearson correlation coefficients were determined between CS, ES, XRS and BALFS. Only significant correlation coefficients (>0.60) were considered. One way variance analyses were used to compare the two groups. A discriminant analysis model was adjusted on the RAO staging method suggested. There was a significant correlation coefficient between the CS cough, nostril flare and abdominal lift, all the mucus ES (0.61-0.84), the XRS interstitial pattern, bronchial radiopacity and thickening and tracheal thickening (0.67-0.78) and the BALFS neutrophil percentages (0.63-0.84). These variables (e.g., cough) which presented a significant correlation coefficient were considered relevant and chosen for a score model to characterize RAO stages. The ten healthy controls were attributed stage 0 and the 30 RAO horses were attributed stages 1 (4 horses), 2 (7 horses), 3 (10 horses) and 4 (9 horses). There was also a significant correlation coefficient between all the relevant variables and the RAO stage (0.61-0.89). Furthermore, discriminant analysis of the RAO staging method showed 92.5% of original grouped cases and 85.0% of cross-validated grouped cases correctly classified, having confirmed major contribution of the same variables that had significant correlation coefficients. Even though further confirmation by lung functional testing is desirable, the significant correlation between relevant variables and RAO stage and the results of RAO staging discriminant analysis support the suggestion of our score model for the characterization of RAO stages. PMID:22136797

Tilley, P; Sales Luis, J P; Branco Ferreira, M

2012-10-01

118

Segmented corpus callosum diffusivity correlates with the Expanded Disability Status Scale score in the early stages of relapsing-remitting multiple sclerosis  

Scientific Electronic Library Online (English)

Full Text Available OBJECTIVE: The aim of this study was to characterize the microscopic damage to the corpus callosum in relapsing-remitting multiple sclerosis (RRMS) with diffusion tensor imaging and to investigate the correlation of this damage with disability. The diffusion tensor imaging parameters of fractional [...] anisotropy and mean diffusivity provide information about the integrity of cell membranes, offering two more specific indices, namely the axial and radial diffusivities, which are useful for discriminating axon loss from demyelination. METHOD: Brain magnetic resonance imaging exams of 30 relapsing-remitting multiple sclerosis patients and 30 age- and sex-matched healthy controls were acquired in a 3T scanner. The axial diffusivities, radial diffusivities, fractional anisotropy, and mean diffusivity of five segments of the corpus callosum, correlated to the Expanded Disability Status Scale score, were obtained. RESULTS: All corpus callosum segments showed increased radial diffusivities and mean diffusivity, as well as decreased fractional anisotropy, in the relapsing-remitting multiple sclerosis group. The axial diffusivity was increased in the posterior midbody and splenium. The Expanded Disability Status Scale scores correlated more strongly with axial diffusivities and mean diffusivity, with an isolated correlation with radial diffusivities in the posterior midbody of the corpus callosum. There was no significant correlation with lesion loads. CONCLUSION: Neurological dysfunction in relapsing-remitting multiple sclerosis can be influenced by commissural disconnection, and the diffusion indices of diffusion tensor imaging are potential biomarkers of disability that can be assessed during follow-up.

Carolina de Medeiros, Rimkus; Thiago de Faria, Junqueira; Dagoberto, Callegaro; Maria Concepcion Garcia, Otaduy; Claudia da Costa, Leite.

1115-11-01

119

Value of Indian Diabetes Risk Score among Medical Students and Its Correlation with Fasting Plasma Glucose, Blood Pressure and Lipid Profile  

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Introduction The Indian Diabetes Risk Score is a tool which was devised by the Madras Diabetes Research Foundation to screen people for the risk of developing Diabetes mellitus; it comprises of the family history, the abdominal circumference, age and the physical activity. Aim of the Study This study was aimed at finding out whether the Indian Diabetes Risk Score (MDRF) correlated with the blood sugar levels, the lipid profile and the blood pressure readings of medical students. Methods Seventy five female and 75 male students who signed the informed consent were selected for the study. Their IDRS was calculated by using a validated questionnaire which involved the family history, the abdominal circumference, age and the details of the physical activity. All of them had their blood pressure, fasting plasma glucose and lipid profiles measured. Results There were 101 students with an IDRS of <30, 42 students with a moderate IDRS (30-50) and 7 who had a high IDRS of ?60. The fasting plasma glucose was significantly correlated with the IDRS (P=0.001, r = 0.472), with a mean FPG of 84 ± 3.63mg/dl in the low risk groups, of 88 ± 4.93mg/dl in the moderate risk groups and of 94 ± 6.50mg/dl in the high risk groups. The total cholesterol value was r = 0.420 (P= 0.001), the total triglycerides value was r = 0.373 (P=0.001), the LDL cholesterol value was r = 0.578 (P=0.001) and the VLDL value was r = 0.566 (P=0.001), which positively correlated with the risk score and the HDL value r = -0.480 (P=0.001) correlated negatively with the risk score. There was no correlation between the IDRS and the blood pressure. Conclusion Our study showed that nearly 40% of the medical students had a moderate to a high IDRS. The IDRS significantly correlated with the fasting plasma glucose and with all the components of the lipid profile. The IDRS did not correlate with the blood pressure readings. PMID:23285447

Vardhan, Anand; Prabha M.R., Adhikari; Shashidhar M., Kotian; Shankar, Nithya; Gupta, Sandhya; Tripathy, Amruta

2012-01-01

120

Fetal bone age revisited: proposal of a new radiographic score  

International Nuclear Information System (INIS)

In order to establish a fetal bone age score, the post-mortem skeletal radiographs of 85 selected normal fetuses aged from 15 to 41 weeks of gestation (WG) were analysed. Twenty-eight skeletal areas were selected for which quantitative and/or qualitative criteria were defined. Each new aspect was graded and statistically tested by the stepwise linear regression method. Two modalities of scores of decreasing complexity were then designed. The use of these two scores permitted the assessment of the fetal age with r2 values of 0.97 and 0.96 (standard error of estimation of 1.19 and 1.36 WG). Applied to 15 intrauterine growth retardation (IUGR) fetuses, the age estimated by these scores was well correlated with the age obtained by extraosseous criteria of maturation. This method is proposed as a tool for determining the fetal age during necropsy and could also be useful in US prenatal evaluation. (orig.)

121

A correlation between characteristics and students’ perception with the last score of field experience study at community based medicine  

OpenAIRE

Field experience study (FES) is one of the Community Based Medicine Education Programs that has done in Faculty of Medicine University of Malahayati. The aims of this study were to identify several factors related to final FES score. The questionnaires were given for all field study participants. It consisted of students’ characteristics and perception on field study. This FES was conducted on 3 September 2007. Cox regression was used to analyze data using STATA version 9.0. Gender, previou...

Marisa Anggraini; Abdul Latief

2008-01-01

122

WHO-histological criteria for myeloproliferative neoplasms: reproducibility, diagnostic accuracy and correlation with gene mutations and clinical outcomes.  

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Bone marrow histology is included in the diagnostic criteria of myeloproliferative neoplasms (MPNs). However, some concerns have emerged about its reproducibility. To evaluate the diagnostic accuracy of histology and to assess its correlation with presence of mutations and clinical outcomes, two pathologists reviewed the bone marrow biopsies corresponding to 211 patients with MPN. Despite the low agreement in the evaluation of individual histopathological characteristics, the concordance among pathologists when establishing the diagnosis was good (Kappa index 0·67). The specificity of histology was 100%, 98·5% and 98% in polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF), respectively, whereas the sensitivity of histological diagnosis was low in PV and ET (32·5% and 54% respectively) and acceptable in PMF (75%). Thirteen out of 146 (9%) patients with clinical ET were diagnosed as prefibrotic PMF. No histological agreement or MPN otherwise unspecified was more frequently observed in JAK2 V617F-positive ET than in CALR-mutated cases, whereas megakaryocytic abnormalities and prefibrotic PMF were more frequently observed in CALR-mutated ET. In conclusion, histological criteria of MPN have a limited diagnostic accuracy due to low sensitivity. Patients with JAK2 V617F-positive MPN have a heterogeneous histology while CALR-positive ET is associated with megakaryocyte abnormalities and prefibrotic PMF. PMID:24957246

Alvarez-Larrán, Alberto; Ancochea, Agueda; García, Mar; Climent, Fina; García-Pallarols, Francesc; Angona, Anna; Senín, Alicia; Barranco, Carlos; Martínez-Avilés, Luz; Serrano, Sergio; Bellosillo, Beatriz; Besses, Carlos

2014-09-01

123

Assessment of patients with disorder of consciousness: do different Coma Recovery Scale scoring correlate with different settings?  

Science.gov (United States)

Differential diagnosis between Vegetative State and Minimally Conscious State is a challenging task that requires specific assessment scales, involvement of expert neuropsychologists or physicians and use of tailored stimuli for eliciting behavioural responses. Although misdiagnosis rate as high as 40% has been reported, no clear guidelines are available in literature on the optimal setting for assessment. The present study aims to analyse score differences in behavioural assessments of persons with disorders of consciousness (DOC) with or without family members and to determine whether the presence of caregivers could improve clinical accuracy in diagnostic evaluation. The research was conducted on 92 adults with DOC among 153 consecutive patients enrolled in the Coma Research Centre of the Neurological Institute C. Besta of Milan between January 2011 and May 2013. The results indicate that in almost half of the sample the scoring, thus the performance, observed with caregivers was better than without them. Furthermore, in 16% of the sample, when assessment was performed with caregivers there was a change in diagnosis, from Vegetative to Minimally Conscious State or from that to Severe Disability. Finally, statistical differences were found in relation to diagnosis between mean scores in the "visual function" Coma Recovery Scale revised's subscale obtained by raters plus caregiver and rates only assessment. This study demonstrates how the presence of caregivers can positively affect behavioural assessments of persons with DOC, thus contributing to the definition of the optimal setting for behavioural evaluation of patients, to decrease misdiagnosis rates. PMID:25239389

Sattin, Davide; Giovannetti, Ambra M; Ciaraffa, Francesca; Covelli, Venusia; Bersano, Anna; Nigri, Anna; Ferraro, Stefania; Minati, Ludovico; Rossi, Davide; Duran, Dunja; Parati, Eugenio; Leonardi, Matilde

2014-12-01

124

Computer-Aided Quantification of Interstitial Lung Disease from High Resolution Computed Tomography Images in Systemic Sclerosis: Correlation with Visual Reader-Based Score and Physiologic Tests  

Science.gov (United States)

Objective. To evaluate the performance of a computerized-aided method (CaM) for quantification of interstitial lung disease (ILD) in patients with systemic sclerosis and to determine its correlation with the conventional visual reader-based score (CoVR) and the pulmonary function tests (PFTs). Methods. Seventy-nine patients were enrolled. All patients underwent chest high resolution computed tomography (HRCT) scored by two radiologists adopting the CoVR. All HRCT images were then analysed by a CaM using a DICOM software. The relationships among the lung segmentation analysis, the readers, and the PFTs results were calculated using linear regression analysis and Pearson's correlation. Receiver operating curve analysis was performed for determination of CaM extent threshold. Results. A strong correlation between CaM and CoVR was observed (P < 0.0001). The CaM showed a significant negative correlation with forced vital capacity (FVC) (P < 0.0001) and the single breath carbon monoxide diffusing capacity of the lung (DLco) (P < 0.0001). A CaM optimal extent threshold of 20% represented the best compromise between sensitivity (75.6%) and specificity (97.4%). Conclusions. CaM quantification of SSc-ILD can be useful in the assessment of extent of lung disease and may provide reliable tool in daily clinical practice and clinical trials. PMID:25629053

Salaffi, Fausto; Carotti, Marina; Bosello, Silvia; Bichisecchi, Elisabetta; Giuseppetti, Gianmarco; Ferraccioli, Gianfranco

2015-01-01

125

Criteria of GenCall score to edit marker data and methods to handle missing markers have an influence on accuracy of genomic predictions  

DEFF Research Database (Denmark)

The aim of this study was to investigate the effect of different strategies for handling low-quality or missing data on prediction accuracy for direct genomic values of protein yield, mastitis and fertility using a Bayesian variable model and a GBLUP model in the Danish Jersey population. The data contained 1071 Jersey bulls that were genotyped with the Illumina Bovine 50K chip. After preliminary editing, 39227 SNP remained in the dataset. Four methods to handle missing genotypes were: 1) BEAGLE: missing markers were imputed using Beagle 3.3 software, 2) COMMON: missing genotypes at a locus were replaced by the most common genotype at this locus observed in the marker data, 3) EX-ALLELE: missing marker genotypes at a locus were treated as an extra allele, and 4) POP-EXP: missing genotypes at a locus were replaced with population expectation at this locus. It was shown that among the methods used in this study, imputation with Beagle was the best approach to handle missing genotypes. Treating missing markers as a pseudo-allele, replacing missing markers with a population average or substituting the most common alleles each reduced the accuracy of genomic predictions. The results from this study suggest that missing genotypes should be imputed in order to improve genomic prediction. Editing the marker data with stringent threshold on GenCall (GC) scores and then imputing the discarded genotypes did not lead to higher accuracy. All marker genotypes with a GC score over 0.15 should be retained for genomic prediction

Edriss, Vahid; Guldbrandtsen, Bernt

2013-01-01

126

Lack of cytokine-induced skin reaction correlates with acute physiology score and mortality in patients receiving intensive care.  

Science.gov (United States)

Because the majority of patients receiving intensive care are anergic to ubiquitous skin test antigens, prediction of clinical outcome cannot be based on their delayed-type hypersensitivity score, which is 0, but which is also a strong indicator of sepsis-related mortality in the preoperative patient. However, a cytokine-rich supernatant generated in the mixed lymphocyte culture reaction is able to induce an early skin reaction that peaks at 12 hours and wanes by 24 hours in some, but not all, anergic patients. Assessment of the clinical course of these patients demonstrated that only three of 25 patients who had a skin reaction larger than 5 mm died, compared with ten of 16 patients who failed to display this early reaction. Further analysis showed that both the cytokine-induced reaction and the acute physiology score significantly and independently contributed to the probability of death in anergic patients. These data suggest that the ability to generate a local inflammatory response to cytokines in anergic patients identifies a subpopulation of patients who have maintained some host-defense responsiveness and this response can be utilized to predict outcome. PMID:3056333

Puyana, J C; Rode, H; Gordon, J; Meakins, J L; Chartrand, L; Christou, N V

1988-12-01

127

Estimating a Multivariate Familial Correlation Using Joint Models for Canonical Correlations: Application to Memory Score Analysis from Familial Hispanic Alzheimer's Disease Study  

OpenAIRE

Analysis of multiple traits can provide additional information beyond analysis of a single trait, allowing better understanding of the underlying genetic mechanism of a common disease. To accommodate multiple traits in familial correlation analysis adjusting for confounders, we develop a regression model for canonical correlation parameters and propose joint modeling along with mean and scale parameters. The proposed method is more powerful than the regression method modeling pairwise correla...

Lee, Hye-seung; Paik, Myunghee Cho; Lee, Joseph H.

2008-01-01

128

Cervical lymph node metastasis: correlative study of CT, ultrasound and pathology. Pt. 1. Criteria for evaluating cervical lymph node metastasis  

International Nuclear Information System (INIS)

Purpose: To evaluate the criteria of CT, ultrasonography and combination of the two in the diagnosis of cervical lymph node metastases. Materials and methods: Sixty patients were prospectively studied by CT and ultrasonography prior to cervical lymph node dissection, and correlated with pathologic specimens. The results were studied in double-blind way. Results: The minimal nodal diameter?8 mm as the diagnosis threshold was used for deep jugular chain nodes for CT or US, the sensitivity was 91.67%, 83.33% and specificity was 98.61% and 97.22% respectively. For level VII (nodes located in tracheoesophageal groove), minimal diameter?5 mm was used as diagnostic threshold of CT, the sensitivity was 69.23%, specificity was 100%. With contrast enhanced CT, nodes with enhancing rim and central low attenuation were shown in 44 nodal regions, all were proved pathologically as metastases (specificity, 100%). Conclusion: Using contrast enhanced CT as the basic imaging modality, the minimal diameter?8 mm can be used as the criterion of size of metastasis in deep jugular chain (level II?IV) nodes. For the tracheoesophageal groove node (level VII), minimal diameter?5 mm is more acceptable. Enhancing rim with central low attenuation is a reliable sign for diagnosing cervical lymph node metastases, in patients with known primary cancer

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Reproducibility of a scoring system for gram stain diagnosis of bacterial vaginosis.  

OpenAIRE

A total of 225 pairs of duplicate Gram-stained slides from three hospitals in Jakarta were evaluated independently by a local (University of Indonesia, Jakarta) and a referral (University of Washington, Seattle) laboratory by the new scoring criteria proposed by Nugent et al. The correlation coefficients of the duplicate Gram stain scores ranged from 0.65 to 0.83. The kappa statistics for the bacterial vaginosis category (no, score of 0 to 6; yes, score of 7 to 10) ranged from 0.62 to 0.77. T...

Joesoef, M. R.; Hillier, S. L.; Josodiwondo, S.; Linnan, M.

1991-01-01

130

Correlación entre índices de bioimpedancia eléctrica y score Apache II en pacientes con shock séptico / Correlation between indexes of electrical bioimpedance and Apache II score in patients with septic shock  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Objetivo: Determinar la correlación entre diversos índices de bioimpedancia eléctrica (IBE) y el score APACHE II (sAII) en pacientes con shock séptico. Material y métodos: Se incluyeron 30 pacientes >14 años con shock séptico de la unidad de cuidados intensivos (UCI) adultos del Hospital Nacional Ca [...] yetano Heredia-Perú a quienes se calculó el (sAII) y se midió el ángulo de fase, índice de impedancia y relación LIC/LEC, correlacionándolos posteriormente mediante Pearson y regresión lineal múltiple. Resultados: El 60% fueron varones, la edad promedio fue 60 ± 20,92 años, talla 1,61 ± 0,06m, peso 65,46 ± 8,7 Kg. y tiempo de ingreso a UCI 8,4 ± 5,99 horas. El 86,6% requirió ventilación mecánica, el foco infeccioso más frecuente fue respiratorio (63,3%). El promedio del sAII fue 18,83 ± 9,23, la permanencia en UCI 8,4 ± 5,99 días y la letalidad al mes 50%. Solamente se encontró correlación negativa con significancia estadística (r = -0,46; p = 0,01) entre el ángulo de fase (AF) y el (sAII). Ni el índice de impedancia ni la relación LIC/LEC tuvieron correlación significativa. El mejor predictor de mortalidad fue el AF: todos los que fallecieron tuvieron un AF Abstract in english Objective: Objective: To determine the correlation between various indexes of bioelectrical impedance (IBE) and APACHE II score (sAII) in patients with septic shock. Material and methods: We included 30 patients > 14 years old with septic shock admitted to the Adults intensive care unit (ICU) at the [...] Hospital Nacional Cayetano Heredia – Peru. The (sAII) was calculated and various IBE parameters were measured (phase angle, impedance index and relationship ICF/ECF). Correlations were calculated by multiple linear regression and Pearson. Results: 60% were male, mean age was 60 ± 20.92 years, height 161 ± 6 cm, weight 65.46 ± 8.7 kg and time of admission ICU was 8.4 ± 5.99 hours. 86.6% required mechanical ventilation, the most common infection was respiratory in origin (63.3%). The mean sAII was 18.8 ± 9.2, ICU stay was 8.4 ± 5.99 days and mortality was 50% per month. We only found a statistically significant negative correlation (r = - 0.46, p = 0.01) between the phase angle (FA) and (sAII). Neither the impedance index nor the relationship ICF/ECF had significant correlation. The best predictor of mortality was FA: those who died had an FA

Manuel, Díaz-De Los Santos; Javier, Cieza; Raúl, Valenzuela.

2010-07-01

131

Heritabilities and genetic correlations of body condition score and muscularity with productive traits and their trend functions in Italian Simmental cattle  

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Full Text Available With the aim to study the genetics of energy and muscle balance in the Italian Simmental breed, the objectives of this study were: i the estimation of the genetic parameters for body condition score (BCS and muscularity (MU score; ii the estimation of genetic correlations of BCS and MU with productive traits; iii the estimation of the expected pattern of BCS and MU over lactation. A total of 47,839 records of first-parity lactating cows, collected from 1999 to 2007 in 2794 herds, were used. Two-trait animal models were analyzed using restricted maximum likelihood (REML procedures to estimate (covariance components. The expected patterns of BCS and MU along the lactation of first parity cows were estimated from the solutions of DIM fixed effect obtained from an univariate mixed model for both the traits. The heritability estimated was 0.18 for BCS, 0.38 for MU, and ranged from 0.13 to 0.18 for yield traits. The genetic correlations between BCS, MU and yield traits were negative (-0.17 to -0.63. The genetic correlation between BCS and MU was strongly positive (0.88, indicating that cows that genetically tend to have high BCS are more likely to have high values of MU. The genetic parameters estimated suggested that selection for BCS and MU in dual purpose breeds may be possible, and BCS may indirectly improve MU. The expected patterns for BCS and MU showed the trend of these two traits along the lactation and can help farmers in planning the best management of the lactating cows.

Alessandro Bagnato

2013-04-01

132

Assessment of the metabolic flow phenotype of primary colorectal cancer: correlations with microvessel density are influenced by the histological scoring method  

International Nuclear Information System (INIS)

To investigate how the histological scoring of microvessel density affects correlations between integrated 18F-FDG-PET/perfusion CT parameters and CD105 microvessel density. A total of 53 patients were enrolled from 2007 to 2010. Integrated 18F-FDG-PET/perfusion CT was successful in 45 patients, 35 of whom underwent surgery without intervening treatment. Tumour SUVmax, SUVmean and regional blood flow (BF) were derived. Immunohistochemical staining for CD105 expression and analysis were performed for two hot spots, four hot spots and the Chalkley method. Correlations between metabolic flow parameters and CD105 expression were assessed using Spearman's rank correlation. Mean (SD) for tumour size was 38.5 (20.5) mm, for SUVmax, SUVmean and BF it was 19.1 (4.5), 11.6 (2.5) and 85.4 (40.3) mL/min/100 g tissue, and for CD105 microvessel density it was 71.4 (23.6), 66.8 (22.9) and 6.18 (2.07) for two hot spots, four hot spots and the Chalkley method, respectively. Positive correlation between BF and CD105 expression was modest but higher for Chalkley than for four hot spots analysis (r = 0.38, P = 0.03; r = 0.33, P = 0.05, respectively). There were no significant correlations between metabolic parameters (SUVmax or SUVmean) and CD105 expression (r = 0.08-0.22, P = 0.21-0.63). The histological analysis method affects correlations between tumour CD105 expression and BF but not SUVmaxmax or SUVmean. (orig.)

133

Assessment of the metabolic flow phenotype of primary colorectal cancer: correlations with microvessel density are influenced by the histological scoring method  

Energy Technology Data Exchange (ETDEWEB)

To investigate how the histological scoring of microvessel density affects correlations between integrated {sup 18}F-FDG-PET/perfusion CT parameters and CD105 microvessel density. A total of 53 patients were enrolled from 2007 to 2010. Integrated {sup 18}F-FDG-PET/perfusion CT was successful in 45 patients, 35 of whom underwent surgery without intervening treatment. Tumour SUV{sub max}, SUV{sub mean} and regional blood flow (BF) were derived. Immunohistochemical staining for CD105 expression and analysis were performed for two hot spots, four hot spots and the Chalkley method. Correlations between metabolic flow parameters and CD105 expression were assessed using Spearman's rank correlation. Mean (SD) for tumour size was 38.5 (20.5) mm, for SUV{sub max}, SUV{sub mean} and BF it was 19.1 (4.5), 11.6 (2.5) and 85.4 (40.3) mL/min/100 g tissue, and for CD105 microvessel density it was 71.4 (23.6), 66.8 (22.9) and 6.18 (2.07) for two hot spots, four hot spots and the Chalkley method, respectively. Positive correlation between BF and CD105 expression was modest but higher for Chalkley than for four hot spots analysis (r = 0.38, P = 0.03; r = 0.33, P = 0.05, respectively). There were no significant correlations between metabolic parameters (SUV{sub max} or SUV{sub mean}) and CD105 expression (r = 0.08-0.22, P = 0.21-0.63). The histological analysis method affects correlations between tumour CD105 expression and BF but not SUV{sub max} or SUV{sub mean}. (orig.)

Goh, Vicky [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Rodriguez-Justo, Manuel [University College Hospital, Department of Histopathology, London (United Kingdom); Engledow, Alec; Peck, Jacqui [University College Hospital, Department of Surgery, London (United Kingdom); Shastry, Manu; Endozo, Raymondo; Meagher, Marie; Groves, Ashley M. [University College Hospital, Institute of Nuclear Medicine, London (United Kingdom); Taylor, Stuart A.; Halligan, Steve [University College Hospital, Specialist Radiology, London (United Kingdom)

2012-08-15

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Bone mineral density (BMD) composite index scores developed from bone densitometry (DXA and QCT) simplifies correlative and predictive analyses in adolescent's bone health  

International Nuclear Information System (INIS)

Full text: Introduction and aim. Adolescence is a critical period to accumulate 50-70% of adult's bone mass. Hence, precise bone mass determination is important to monitor BMD development among adolescents in health and disease. It is uncertain at which skeletal site BMD is best predicted by bone-mass determinants. Besides, BMD measured at different sites of an individual can be condensed into a composite-index-score to simplify correlation, outcome prediction and data interpretation. This study describes the development of BMD composite index scores (BMD-CISs) to correlate with bone growth determinants in adolescents. Subjects and methods BMD measurements using DXA: Norland-XR36 (spine, femoral-neck, trochanter and Ward's triangle) and pQCT: Denisiscan-2000 (distal-radius and tibia) were obtained from 101 healthy girls aged 12-15 years to develop the BMD-CISs. Adolescent bone growth predictors (weight, height, pubertal-status, weight-bearing physical-exercise and bone-turnover markers) were evaluated to correlate with BMD-CISs. Factor and principle-component analyses were used to examine the internal structure of 11 BMD skeletal sites and variables, and to create new BMD-CISs which summarize the characteristics of parent BMD-variables. Correlations between the BMD-CISs and parent BMD variables were performed. Univariate and multivariate analysis were performed to associate BMD-CISs with bone growth predictors for examining the strength of correlations and predictionse strength of correlations and predictions when compared with the original BMD variables. Results. Two independent DXA-generated BMD-CIS and pQCT-generated BMD-CIS were obtained to summarize the 11 original BMD variables. Each BMD-CIS correlated highly with respective DXA or pQCT variable (r=0.32-0.92; P<0.05 - P<0.001). DXA generated BMD-CIS (r=0.24 - 0.73; P<0.05-P<0.001) and pQCT-generated BMD-CIS (r=0.24-0.39; P<0.05-P<0.001) were significantly correlated with most bone growth predictors. In multiple regression analysis, R-square of DXA-BMD-CIS (66.4% vs. 36.3%-66.1%) and pQCT-BMD- CIS (25.1% vs. 12.2%-42.2%) have similar predicting values when compared with parent BMD variables demonstrated that the two new BMD-CISs summarized well the characteristics of the parent BMD variables. Furthermore, areal spinal BMD (by DXA) and volumetric tibial integral BMD (by pQCT) were the BMD sites better predicted by bone-mass determinants (R-squares 0.6-0.8) in multiple regression analysis. Discussion and conclusions. The newly developed BMD-CISs correlated well with original variables and have similar predicting powers when compared with the original BMD variables. The use of BMD-CISs would reduce workload of data analysis and simplify correlation and comparisons between multiple BMD measurements and other predicting variables. Identification of 1-2 skeletal sites better associated with health predictive variables could help reduce the number of skeletal sites for BMD measurement, thus, reducing subject's exposure to unnecessary X ray irradiation. (author)

135

Insulin-like growth factor (IgF)-I, IgF binding protein-3, and prostate cancer: correlation with gleason score  

Scientific Electronic Library Online (English)

Full Text Available Introduction Non-androgenic growth factors are involved in the growth regulation of prostate cancer (PCa). Objective This is the first Brazilian study to correlate, in a population of patients operated for PCa, PSA, total testosterone, insulin-like growth factor-I (IGF-I) and insulin-like growth fa [...] ctor-binding protein-3 (IGFBP-3) with Gleason score and to compare with a control group with benign prostate hyperplasia (BPH). Materials and Methods This retrospective single-center study included 49 men with previously diagnosed PCa and 45 with previously diagnosed BPH. PSA, testosterone, IGF-I, IGFBP-3 were determined in both groups. Results PSA and IGFBP-3 levels were significantly higher in the PCa group as compared to the BPH group (p

Lívia L., Corrêa; Leonardo, Vieira Neto; Giovanna A. Balarini, Lima; Rafael, Gabrich; Luiz Carlos D. de, Miranda; Mônica R., Gadelha.

2015-02-01

136

Score 2009  

Science.gov (United States)

Objectives/Purpose: The SCORE 2009 workshop has been conducted annually for the past eight years. This workshop brings together key program personnel and site coordinators, research nurses, data managers, and quality assurance officers from institutions

137

Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70  

Directory of Open Access Journals (Sweden)

Full Text Available Michelle E Orme,1 Katherine S MacGilchrist,2 Stephen Mitchell,2 Dean Spurden,3 Alex Bird31Icera Consulting, Swindon, Wiltshire, UK; 2Systematic Review Department, Abacus International, Bicester, Oxfordshire, UK; 3Pfizer UK Limited, Tadworth, Surrey, UKBackground: Biologic disease-modifying antirheumatic drugs (bDMARDs extend the treatment choices for rheumatoid arthritis patients with suboptimal response or intolerance to conventional DMARDs. The objective of this systematic review and meta-analysis was to compare the relative efficacy of EU-licensed bDMARD combination therapy or monotherapy for patients intolerant of or contraindicated to continued methotrexate.Methods: Comprehensive, structured literature searches were conducted in Medline, Embase, and the Cochrane Library, as well as hand-searching of conference proceedings and reference lists. Phase II or III randomized controlled trials reporting American College of Rheumatology (ACR criteria scores of 20, 50, and 70 between 12 and 30 weeks' follow-up and enrolling adult patients meeting ACR classification criteria for rheumatoid arthritis previously treated with and with an inadequate response to conventional DMARDs were eligible. To estimate the relative efficacy of treatments whilst preserving the randomized comparisons within each trial, a Bayesian network meta-analysis was conducted in WinBUGS using fixed and random-effects, logit-link models fitted to the binomial ACR 20/50/70 trial data.Results: The systematic review identified 10,625 citations, and after a review of 2450 full-text papers, there were 29 and 14 eligible studies for the combination and monotherapy meta-analyses, respectively. In the combination analysis, all licensed bDMARD combinations had significantly higher odds of ACR 20/50/70 compared to DMARDs alone, except for the rituximab comparison, which did not reach significance for the ACR 70 outcome (based on the 95% credible interval. The etanercept combination was significantly better than the tumor necrosis factor-? inhibitors adalimumab and infliximab in improving ACR 20/50/70 outcomes, with no significant differences between the etanercept combination and certolizumab pegol or tocilizumab. Licensed-dose etanercept, adalimumab, and tocilizumab monotherapy were significantly better than placebo in improving ACR 20/50/70 outcomes. Sensitivity analysis indicated that including studies outside the target population could affect the results.Conclusion: Licensed bDMARDs are efficacious in patients with an inadequate response to conventional therapy, but tumor necrosis factor-? inhibitor combination therapies are not equally effective.Keywords: bDMARD, rheumatoid arthritis, etanercept, systematic review, network meta-analysis, comparative effectiveness

Orme ME

2012-12-01

138

Correlação da técnica bottom turn com as notas atribuídas no surf de alto rendimento / Correlation of the bottom turn technique with the scores attributed in high performance surfing  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese As competições de surf no cenário mundial têm apresentado um alto e homogêneo nível de desempenho entre os atletas. Assim, atentou-se à hipótese de que o bottom turn (BT), curva na base da onda essencial para a construção de manobras subsequentes, pode afetar os resultados alcançados em baterias de [...] surf de alto rendimento. O estudo teve como objetivo quantificar o tempo que os atletas levam na execução de BT em suas ondas e correlacioná-lo com as notas atribuídas. A amostra foi composta por quatro eventos do World Tour de Surf, sendo avaliadas 4 baterias de cada evento, perfazendo um total de 16 baterias investigadas. A análise de cada BT foi realizada por meio do recurso de corte de vídeo disponível no programa Sony Vegas Pro 10.0. A análise estatística foi implementada no software SPSS 18.0, sendo calculado o coeficiente de correlação de Pearson, com nível de significância de p Abstract in english The surf contests worldwide have presented a high and homogeneous level of performance by the athletes. Thus, the hypothesis that the bottom turn (BT), curve on the base of the wave which is essential to the construction of subsequent maneuvers, might influence the results in high performance compet [...] itions. The objective of this study was to quantify the time taken in the execution of the BT by the athletes and correlate it to the scores awarded. The research sample was composed of four contests of the Surfing World Tour. Four heats of each contest were assessed, in a total of sixteen heats studied. The analysis of each BT was performed by using the video split feature available in the Sony Vegas Pro 10.0 software. The statistic analysis was performed with the software SPSS 18.0. The Pearson correlation coefficient was calculated with a significance level of p

Pedro Caetano, Souza; Marcos Augusto, Rocha; Juarez Vieira do, Nascimento.

139

Insulin-like growth factor II mRNA binding protein 3 (IMP3 is overexpressed in prostate cancer and correlates with higher Gleason scores  

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Full Text Available Abstract Background The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3 is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Methods Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC. IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. Results IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p Conclusions Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed.

Mortezavi Ashkan

2010-06-01

140

SOCIAL SCORING ?????????? ???????  

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Full Text Available The new approach to the classification of the client by a method of credit scoring on the basis of the profiles of social networks is considered in the article. The approach illustrates interaction with social networks as new data source in credit process. Statistical methods of data processing and corresponding to them mathematical tools were involved in the analysis. The description of this approach is kept within the made experiment

Skiba S. A.

2013-09-01

141

Correlação dos escores de risco com a anatomia coronária na síndrome coronária aguda sem supra-ST / Correlation of risk scores with coronary anatomy in non-ST-elevation acute coronary syndrome  

Scientific Electronic Library Online (English)

Full Text Available FUNDAMENTO:Há poucas publicações sobre a correlação entre escores de risco e anatomia coronária na síndrome coronária aguda (SCA). OBJETIVO: Correlacionar os escores de risco com a gravidade da lesão coronária na SCA sem supra-ST. MÉTODOS: Foram analisados 582 pacientes entre julho de 2004 e outubro [...] de 2006. Avaliou-se a correlação entre os escores de risco TIMI, GRACE hospitalar e em seis meses com lesão coronária > 50%, por método não paramétrico de Spearman. Modelo de regressão logística múltipla foi realizado para determinar a habilidade preditiva dos escores em discriminar quem terá ou não lesão coronária > 50%. RESULTADOS: Foram 319 (54,8%) homens e a média de idade era 59,9 (± 10,6) anos. Correlação positiva foi observada entre a pontuação dos escores de risco e lesão coronária > 50% (escore de risco TIMI r = 0,363 [p 50% foi: TIMI = 0,704 [IC95% 0,656-0,752; p Abstract in english BACKGROUND: The literature lacks studies regarding the correlation between risk scores and coronary anatomy in acute coronary syndrome (ACS) OBJECTIVE: Correlate risk scores with the severity of the coronary lesion in ACS with non-ST elevation. METHODS: A total of 582 patients were analyzed between [...] July 2004 and October 2006. The correlation between TIMI risk scores and GRACE (hospital and six months) scores was performed for patients with coronary lesion > 50%, using Spearman´s non-parametric method. Multiple regression logistics was used to determine the predictive ability of the scores to discriminate to discriminate who will have a coronary lesion > 50%. RESULTS: Most subjects were male (319 or 54.8%), mean age of 59.9 (± 10.6) years. A positive correlation was observed between risk scores and >coronary lesion > 50% (TIMI r = 0.363 [p 50% was: TIMI = 0.704 [CI95% 0.656-0.752; p

Elizabete Silva dos, Santos; Luciano de Figueiredo, Aguiar Filho; Daniela Menezes, Fonseca; Hugo José, Londero; Rogério Martins, Xavier; Marcos Paulo, Pereira; Luiz, Minuzzo; Roberta de, Souza; Ari, Timerman.

2013-06-01

142

Correlação dos escores de risco com a anatomia coronária na síndrome coronária aguda sem supra-ST Correlation of risk scores with coronary anatomy in non-ST-elevation acute coronary syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available FUNDAMENTO:Há poucas publicações sobre a correlação entre escores de risco e anatomia coronária na síndrome coronária aguda (SCA. OBJETIVO: Correlacionar os escores de risco com a gravidade da lesão coronária na SCA sem supra-ST. MÉTODOS: Foram analisados 582 pacientes entre julho de 2004 e outubro de 2006. Avaliou-se a correlação entre os escores de risco TIMI, GRACE hospitalar e em seis meses com lesão coronária > 50%, por método não paramétrico de Spearman. Modelo de regressão logística múltipla foi realizado para determinar a habilidade preditiva dos escores em discriminar quem terá ou não lesão coronária > 50%. RESULTADOS: Foram 319 (54,8% homens e a média de idade era 59,9 (± 10,6 anos. Correlação positiva foi observada entre a pontuação dos escores de risco e lesão coronária > 50% (escore de risco TIMI r = 0,363 [p 50% foi: TIMI = 0,704 [IC95% 0,656-0,752; p BACKGROUND: The literature lacks studies regarding the correlation between risk scores and coronary anatomy in acute coronary syndrome (ACS OBJECTIVE: Correlate risk scores with the severity of the coronary lesion in ACS with non-ST elevation. METHODS: A total of 582 patients were analyzed between July 2004 and October 2006. The correlation between TIMI risk scores and GRACE (hospital and six months scores was performed for patients with coronary lesion > 50%, using Spearman?s non-parametric method. Multiple regression logistics was used to determine the predictive ability of the scores to discriminate to discriminate who will have a coronary lesion > 50%. RESULTS: Most subjects were male (319 or 54.8%, mean age of 59.9 (± 10.6 years. A positive correlation was observed between risk scores and >coronary lesion > 50% (TIMI r = 0.363 [p 50% was: TIMI = 0.704 [CI95% 0.656-0.752; p <0.0001]; hospital GRACE = 0.623 [CI95% 0.573-0.673; p < 0.0001]; GRACE at six months= 0.562 [CI95% 0.510-0.613; p ;= 0.0255]. Comparing the areas under the ROC curve, it was found: TIMI versus hospital GRACE: p = 0.01; TIMI versus GRACE at six months:p < 0.0001; hospital GRACE versus GRACE at six months: p = 0.0461. CONCLUSION: Risk scores correlate with the severity of coronary lesions, and the TIMI risk score showed the best predictive ability.

Elizabete Silva dos Santos

2013-01-01

143

Cloze analysis in schizophrenic speech: scoring method and raters' education.  

Science.gov (United States)

This report examines two methodologic concerns pertaining to use of the cloze procedure in studying the predictability of schizophrenic speech, scoring criteria and raters' education (at or below college level). We find that two strategies for scoring the predictions of raters, one requiring the exact word, the other permitting a reasonable synonym, do not appear to differ in distinguishing groups of patients. The accuracy of raters' guessing is, however, correlated with raters' education: the more educated the rater, the more accurate the guessing. Thought-disordered schizophrenic speech is significantly less predictable than that of nonthought-disordered schizophrenics and normal controls when scored by less educated raters. These differences diminish when more highly educated raters are used. We conclude that raters' education can influence the sensitivity of cloze analysis. PMID:3226847

Maher, B A; Manschreck, T C; Weisstein, C C; Schneyer, M L; Okunieff, R

1988-12-01

144

Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics  

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Full Text Available There is critical need for improved biomarker assessment platforms which integrate traditional pathological parameters (TNM stage, grade and ER/PR/HER2 status with molecular profiling, to better define prognostic subgroups or systemic treatment response. One roadblock is the lack of semi-quantitative methods which reliably measure biomarker expression. Our study assesses reliability of automated immunohistochemistry (IHC scoring compared to manual scoring of five selected biomarkers in a tissue microarray (TMA of 63 human breast cancer cases, and correlates these markers with clinico-pathological data. TMA slides were scanned into an Ariol Imaging System, and histologic (H scores (% positive tumor area x staining intensity 0–3 were calculated using trained algorithms. H scores for all five biomarkers concurred with pathologists’ scores, based on Pearson correlation coefficients (0.80–0.90 for continuous data and Kappa statistics (0.55–0.92 for positive vs. negative stain. Using continuous data, significant association of pERK expression with absence of LVI (p = 0.005 and lymph node negativity (p = 0.002 was observed. p53 over-expression, characteristic of dysfunctional p53 in cancer, and Ki67 were associated with high grade (p = 0.032 and 0.0007, respectively. Cyclin D1 correlated inversely with ER/PR/HER2-ve (triple negative tumors (p = 0.0002. Thus automated quantitation of immunostaining concurs with pathologists’ scoring, and provides meaningful associations with clinico-pathological data.

Yolanda Madarnas

2012-07-01

145

Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy--a single centre, open-label study.  

LENUS (Irish Health Repository)

With the development of increasing numbers of potential therapeutic agents in inflammatory disease comes the need for effective biomarkers to help screen for drug efficacy and optimal dosing regimens early in the clinical trial process. This need has been recognized by the Outcome Measures in Rheumatology Clinical Trials (OMERACT) group, which has established guidelines for biomarker validation. To seek a candidate synovial biomarker of treatment response in psoriatic arthritis (PsA), we determined whether changes in immunohistochemical markers of synovial inflammation correlate with changes in disease activity scores assessing 28 joints (?DAS28) or magnetic resonance imaging synovitis scores (?MRI) in patients with PsA treated with a biologic agent.

Pontifex, Eliza K

2011-01-01

146

Histopathological Study of Chronic Hepatitis B: A Comparative Study of Ishak and METAVIR Scoring Systems  

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Full Text Available Background: Ishak and METAVIR scoring systems are among the most commonly used histopathological systems to evaluate chronic hepatitis.Objective: To assess the level of agreement between these two scoring systems in patients with chronic hepatitis B.Methods: Liver biopsy samples taken from 92 patients with chronic hepatitis B were considered as the training set; 57 more biopsy specimens were used as the validation set. In the training set, grade of necroinflammationand stage of fibrosis for each liver biopsy specimen were determined by two expert liver pathologists using both Ishak and METAVIR systems. Inter-observer variability between the two pathologistswas evaluated. Biopsy specimens of the validation set were seen and scored by a third expert pathologist.In the training set, criteria were developed to categorize Ishak grading and staging systems separately to best fit with the METAVIR scoring system. The criteria found in the training set, was then tested in the validation set. The level of agreement between the two scoring systems was assessed by weighted kappa statistics.Results: For the training set, agreement between the two pathologists was excellent. Using our proposed criteria in the training set, there was excellent level of agreement in grading (? = 0.89 and staging (? = 0.99 between Ishak and METAVIR systems. In the validation set, the criteria led to substantial correlation(? = 0.61 in grading, and excellent correlation (? = 0.94 in staging between the two systems.Conclusion: Using our proposed criteria, excellent or at least substantial concordance between Ishak and METAVIR scoring systems can be achieved for the degree of both necro-inflammatory changes and fibrosis.

M. Sotoudeh

2010-10-01

147

Assessment of hand functions in rheumatoid arthritis using SF-SACRAH (short form score for the assessment and quantification of chronic rheumatoid affections of the hands) and its correlation to disease activity.  

Science.gov (United States)

Rheumatoid arthritis activity is generally evaluated by using DAS-28 score. But this does not reflect the extent of functional hand impairment, a decisive parameter for patient wellbeing as well as for work disability. Several questionnaires to quantify the hand involvement in RA have been elaborated, amongst which SACRAH has been popular since 2003. But this requires evaluating 23 questions on a visual analogue scale. The questions were reduced to 12 in modified-SACRAH (M-SACRAH) and to only five questions in short form SACRAH (SF-SACRAH) so as to make it easily applicable in daily clinical practice. A study was planned to compare M-SACRAH (already validated) to SF-SACRAH in Indian population as no Indian data are available on the same. A total of 100 patients of RA were evaluated for disease activity using DAS-28 score and hand functions using M-SACRAH and SF-SACRAH. The M-SACRAH and SF-SACRAH were then compared based on DAS-28 scores; also M-SACRAH was compared to SF-SACRAH using Spearman's correlation coefficient. The mean value of DAS-28 score was 3.15 ± 0.86. The mean value of SF-SACRAH was 8.065 ± 7.44, and mean value of M-SACRAH was 201.7 ± 201.1008. The correlation of DAS-28 score to SF-SACRAH and M-SACRAH was significant in moderate and high disease activity but insignificant in remission and low disease activity state. The correlation between M-SACRAH and SF-SACRAH showed a spearman's coefficient of 0.998 with a P value of assessed by DAS-28 score) has a poor correlation with hand functions (as assessed by M-SACRAH and SF-SACRAH) especially in low disease activity and remission states. Further, M-SACRAH and SF-SACRAH are significantly correlated. Therefore, it is suggested that RA patients should be assessed by SF-SACRAH (which includes five questions only) in addition to DAS-28 scoring for better evaluation of hand functions, a detrimental factor in day to day performance of RA patients. PMID:22057144

Singh, Harpreet; Kumar, Suresh; Talapatra, Paulomi; Gupta, Vikas; Ray, Sucharita; Kumar, Harish

2012-11-01

148

Obstetrical disseminated intravascular coagulation score.  

Science.gov (United States)

Obstetrical disseminated intravascular coagulation (DIC) is usually a very acute, serious complication of pregnancy. The obstetrical DIC score helps with making a prompt diagnosis and starting treatment early. This DIC score, in which higher scores are given for clinical parameters rather than for laboratory parameters, has three components: (i) the underlying diseases; (ii) the clinical symptoms; and (iii) the laboratory findings (coagulation tests). It is justifiably appropriate to initiate therapy for DIC when the obstetrical DIC score reaches 8 points or more before obtaining the results of coagulation tests. Improvement of blood coagulation tests and clinical symptoms are essential to the efficacy evaluation for treatment after a diagnosis of obstetrical DIC. Therefore, the efficacy evaluation criteria for obstetrical DIC are also defined to enable follow-up of the clinical efficacy of DIC therapy. PMID:24888908

Kobayashi, Takao

2014-06-01

149

Diagnostic value of a breast MRI score for the prediction of malignancy of breast lesions detected solely with MRI; Diagnostische Wertigkeit des Goettinger Scores zur Malignitaetsvorhersage von ausschliesslich in der MRT darstellbaren Mammalaesionen  

Energy Technology Data Exchange (ETDEWEB)

Purpose: to determine whether lesion scoring allows valid BI-RADS registered classification and prediction of malignancy of breast lesions detectable solely with MRI. Materials and methods: retrospective analysis of 86 patients who underwent MRI-guided localization and excisional biopsy of 100 breast lesions detectable only with MRI. Breast MRI was performed at 1.5 Tesla by means of a T1w dynamic GE sequence. The positive predictive value (PPV) for malignancy was calculated for each score criterion separately, for the total score, and for corresponding BI-RADS {sup registered} classes. The PPV was correlated with histology. Results: 31% (31/100) of breast lesions detectable only with MRI were malignant. Of the single score criteria only the lesion morphology criterion was significantly correlated with malignancy. The malignancy rate according to the breast MRI score was 0% for score 3, 18.2% for score 4, 32.1% for score 5 and each 50% for lesions of score 6 and 7. After translation into BI-RADS {sup registered} the malignancy rates were 0% for BI-RADS {sup registered} 3, 24.6% for BI-RADS {sup registered} 4 and 48.5% for BI-RADS {sup registered} 5 lesions. The thus defined BI-RADS {sup registered} classes were significantly correlated with malignancy. (orig.)

Siegmann, K.C.; Baur, A.; Claussen, C.D. [Abt. Diagnostische und Interventionelle Radiologie, Universitaetsklinikum Tuebingen (Germany); Moron, H.U.; Bitzer, M. [Radiologische Abt., Zollernalbklinikum Albstadt (Germany); Hahn, M. [Frauenklinik, Universitaetsklinikum Tuebingen (Germany); Vogel, U. [Pathologisches Inst., Universitaetsklinikum Tuebingen (Germany)

2009-06-15

150

Diagnostic value of a breast MRI score for the prediction of malignancy of breast lesions detected solely with MRI  

International Nuclear Information System (INIS)

Purpose: to determine whether lesion scoring allows valid BI-RADS registered classification and prediction of malignancy of breast lesions detectable solely with MRI. Materials and methods: retrospective analysis of 86 patients who underwent MRI-guided localization and excisional biopsy of 100 breast lesions detectable only with MRI. Breast MRI was performed at 1.5 Tesla by means of a T1w dynamic GE sequence. The positive predictive value (PPV) for malignancy was calculated for each score criterion separately, for the total score, and for corresponding BI-RADS registered classes. The PPV was correlated with histology. Results: 31% (31/100) of breast lesions detectable only with MRI were malignant. Of the single score criteria only the lesion morphology criterion was significantly correlated with malignancy. The malignancy rate according to the breast MRI score was 0% for score 3, 18.2% for score 4, 32.1% for score 5 and each 50% for lesions of score 6 and 7. After translation into BI-RADS registered the malignancy rates were 0% for BI-RADS registered 3, 24.6% for BI-RADS registered 4 and 48.5% for BI-RADS registered 5 lesions. The thus defined BI-RADS registered classes were significantly correlated with malignancy. (orig.)

151

Comparison between Oncotype DX test and standard prognostic criteria in estrogen receptor positive early-stage breast cancer  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To compare the prognosis estimated by standardprognostic criteria versus the prognosis estimated by the OncotypeDX. Methods: A retrospective study was performed on 22 patientswith positive estrogen receptor, early-stage breast cancer whohad an Oncotype DX recurrence score available. Results: Kappavalue between Oncotype DX and standard prognostic criteriawas: Adjuvant! (K = 0.091, Adjuvant! (Transbig (K = 0.182 andNational Comprehensive Cancer Network (K = 0.091. The Fisher’sexact test did not show correlation between Oncotype and standardprognostic criteria. Conclusion: Standard prognostic criteria showedno correlation with Oncotype DX.

Marcelo Roberto Pereira Freitas

2011-09-01

152

Agreement in Computer-Assisted Manual Scoring of Polysomnograms across Sleep Centers  

Science.gov (United States)

Study Objectives: To determine intersite agreement in respiratory event scoring of polysomnograms (PSGs) using different hypopnea definitions. Design: Technical assessment. Setting: Five academic medical centers. Participants: N/A. Interventions: N/A. Measurements and Results: Seventy good-quality PSGs performed in middle-aged women were manually scored by two experienced technologists at each of the five sleep centers using the particular laboratory's own software system. Studies were scored once by each scorer using American Academy of Sleep Medicine (AASM) standards for scoring sleep stages, arousals, and apneas. Hypopneas were then scored using three different AASM criteria: recommended, alternate, and research (Chicago). Means of each PSG variable for the scorers at each site were used to calculate an across-site intraclass correlation coefficient (ICC). Average AHI across the 10 scorers was 7.4 ± 12.3 (standard deviation) events/h using recommended criteria (ICC 0.984; 95% confidence interval [CI] 0.977-0.990), 12.1 ± 13.3 events/h using alternate criteria (ICC 0.947; 95% CI 0.889-0.972), and 15.1 ± 13.9 events/h with Chicago criteria (ICC 0.800; 95% CI 0.768-0.828). ICC across sites was 0.870 (95% CI = 0.847-0.889) for total sleep time, 0.861 (95% CI 0.837-0.881) for number of obstructive apneas and 0.683 (95% CI 0.640-0.722) for number of central apneas. ICCs across sites for hypopneas were very good using recommended criteria (ICC 0.843; 95% CI 0.820-0.870) but decreased when alternate criteria (ICC 0.728; 95% CI 0.689-0.763) and Chicago criteria (ICC 0.535; 95% CI 0.485-0.583) were used. Conclusion: Experienced scorers at different laboratories have very good agreement in hypopnea and AHI results when good-quality PSGs are scored using AASM-recommended criteria. Substantial degradation of reliability was observed for alternative definitions of hypopneas, particularly that proposed for research. Citation: Kuna ST; Benca R; Kushida CA; Walsh J; Younes M; Staley B; Hanlon A; Pack AI; Pien GW; Malhotra A. Agreement in computer-assisted manual scoring of polysomnograms across sleep centers. SLEEP 2013;36(4):583-589. PMID:23565004

Kuna, Samuel T.; Benca, Ruth; Kushida, Clete A.; Walsh, James; Younes, Magdy; Staley, Bethany; Hanlon, Alexandra; Pack, Allan I.; Pien, Grace W.; Malhotra, Atul

2013-01-01

153

Prognostic value of perfusion defect volume at dual energy CTA in patients with pulmonary embolism: Correlation with CTA obstruction scores, CT parameters of right ventricular dysfunction and adverse clinical outcome  

International Nuclear Information System (INIS)

Purpose: To investigate the prognostic value of perfusion defect volume (PDvol) at dual-energy-CT-angiography (DE-CTA) in patients with acute pulmonary embolism (PE) by correlating PDvol with CTA-obstruction-scores (OS), CT parameters of right-ventricular-dysfunction (RVD), and adverse-clinical-outcome. Materials and methods: DE-CTA of 60 patients (mean age: 65 ± 14.4 years) with PE were analyzed. Iodine maps were generated, and normalized PDvol – defined as volume of perfusion defects/total lung volume – was quantified. Furthermore, established prognostic parameters (Qanadli and Mastora-OS, and CT parameters of RVD) were obtained. CT parameters of RVD – namely the right ventricle/left ventricle (RV/LV) diameter ratio measured on transverse sections (RV/LVtrans), four-chamber views (RV/LV4ch), and RV/LV volume ratios (RV/LVvol) – were assessed. PDvol was correlated with OS, CT parameters of RVD and adverse clinical outcome (defined as the need for intensive care treatment or death). Results: 10 of 60 patients with PE experienced adverse clinical outcome. Patients with adverse clinical outcome showed significantly higher PDvol (35 ± 11% vs. 23 ± 10%, p = 0.002), RV/LV ratios (RV/LV4ch 1.46 ± 0.32 vs. 1.18 ± 0.26, p = 0.005; RV/LVvol 2.25 ± 1.33 vs. 1.19 ± 0.56, p = 0.002) and higher Mastora global scores (52 vs. 13, p = 0.02) compared to those without adverse clinical outcome. A weak correlation was observed between PDvol and the Mastora global score (r = 0.5; p = 0.0003), as well as between PDvol and RV/LV4Ch (r = 0.432, p = 0.0006). No correlation was found between PDvol and the Qanadli score or the remainder of the RVD-CT parameters. Conclusion: The extent of perfusion defects as assessed by DE-CTA correlates with adverse clinical outcome in patients with PE. Therefore, volumetric quantification of perfusion defects at DE-CTA allows the identification of low-risk patients who do not require intensified monitoring and treatment.

154

Prognostic value of perfusion defect volume at dual energy CTA in patients with pulmonary embolism: Correlation with CTA obstruction scores, CT parameters of right ventricular dysfunction and adverse clinical outcome  

Energy Technology Data Exchange (ETDEWEB)

Purpose: To investigate the prognostic value of perfusion defect volume (PDvol) at dual-energy-CT-angiography (DE-CTA) in patients with acute pulmonary embolism (PE) by correlating PDvol with CTA-obstruction-scores (OS), CT parameters of right-ventricular-dysfunction (RVD), and adverse-clinical-outcome. Materials and methods: DE-CTA of 60 patients (mean age: 65 {+-} 14.4 years) with PE were analyzed. Iodine maps were generated, and normalized PDvol - defined as volume of perfusion defects/total lung volume - was quantified. Furthermore, established prognostic parameters (Qanadli and Mastora-OS, and CT parameters of RVD) were obtained. CT parameters of RVD - namely the right ventricle/left ventricle (RV/LV) diameter ratio measured on transverse sections (RV/LVtrans), four-chamber views (RV/LV4ch), and RV/LV volume ratios (RV/LVvol) - were assessed. PDvol was correlated with OS, CT parameters of RVD and adverse clinical outcome (defined as the need for intensive care treatment or death). Results: 10 of 60 patients with PE experienced adverse clinical outcome. Patients with adverse clinical outcome showed significantly higher PDvol (35 {+-} 11% vs. 23 {+-} 10%, p = 0.002), RV/LV ratios (RV/LV4ch 1.46 {+-} 0.32 vs. 1.18 {+-} 0.26, p = 0.005; RV/LVvol 2.25 {+-} 1.33 vs. 1.19 {+-} 0.56, p = 0.002) and higher Mastora global scores (52 vs. 13, p = 0.02) compared to those without adverse clinical outcome. A weak correlation was observed between PDvol and the Mastora global score (r = 0.5; p = 0.0003), as well as between PDvol and RV/LV4Ch (r = 0.432, p = 0.0006). No correlation was found between PDvol and the Qanadli score or the remainder of the RVD-CT parameters. Conclusion: The extent of perfusion defects as assessed by DE-CTA correlates with adverse clinical outcome in patients with PE. Therefore, volumetric quantification of perfusion defects at DE-CTA allows the identification of low-risk patients who do not require intensified monitoring and treatment.

Apfaltrer, Paul, E-mail: paul.apfaltrer@medma.uni-heidelberg.de [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Bachmann, Valentin, E-mail: valentin.bachmann@googl.com [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Meyer, Mathias, E-mail: mr.meyer.mathias@gmail.com [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Henzler, Thomas, E-mail: Thomas.Henzler@umm.de [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Barraza, John M., E-mail: barraza@musc.edu [Department of Radiology and Radiological Science, Medical University of South Carolina, PO Box 250322, 169 Ashley Avenue, Charleston, SC 29425 (United States); Gruettner, Joachim, E-mail: joachim.gruettner@umm.de [1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Walter, Thomas, E-mail: Thomas.Walter2@umm.de [1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Schoepf, U. Joseph, E-mail: schoepf@musc.edu [Department of Radiology and Radiological Science, Medical University of South Carolina, PO Box 250322, 169 Ashley Avenue, Charleston, SC 29425 (United States); and others

2012-11-15

155

Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score.  

OpenAIRE

Burning mouth syndrome (BMS) is often an idiopathic chronic and intractable pain condition, affecting 1.5-5.5% of middle-aged and elderly women. We have studied the heat and capsaicin receptor TRPV1, and its regulator nerve growth factor (NGF), in BMS. Patients with BMS (n=10) and controls (n=10) were assessed for baseline and post-topical capsaicin pain scores, and their tongue biopsies immunostained for TRPV1, NGF, and structural nerve markers neurofilament and peripherin. Nerve fibres pene...

Yilmaz, Z.; Renton, T.; Yiangou, Y.; Zakrzewska, J.; Chessell, Ip; Bountra, C.; Anand, P.

2007-01-01

156

Correlações genéticas entre escores visuais e características de carcaça medidas por ultrassom em bovinos de corte / Genetic correlations between visual scores and carcass traits measured by real-time ultrasound in beef cattle  

Scientific Electronic Library Online (English)

Full Text Available O objetivo deste trabalho foi estimar correlações genéticas e fenotípicas entre escores visuais e características de carcaça medidas por ultrassom, para verificar a eficácia desses escores na determinação da musculosidade e na avaliação da carcaça. As características de carcaça medidas por ultrassom [...] foram área de olho de lombo (AOL) e espessura de gordura subcutânea (EG), mensuradas entre a região da 12ª e 13ª costelas, bem como a espessura de gordura subcutânea na garupa (EGP8). As características de estrutura (E), precocidade (P) e musculosidade (M) foram avaliadas por meio de escores visuais. Os componentes de covariância usados para estimar as correlações genéticas e fenotípicas foram obtidos pelo método da máxima verossimilhança restrita, em uma análise multicaracterística. As estimativas de correlações genéticas entre AOL e E, P e M foram 0,54, 0,58 e 0,61, respectivamente, e indicaram que, a longo prazo, a utilização da AOL como critério de seleção poderá produzir animais com maiores escores visuais para essas características. As correlações genéticas estimadas entre as espessuras de gordura (EG e EGP8) e os escores P e M apresentaram comportamento semelhante. Entretanto, as correlações genéticas entre as espessuras de gordura (EG e EGP8) e E foram próximas de zero. As correlações fenotípicas seguiram as mesmas tendências das respectivas correlações genéticas. Essas estimativas indicam que os escores visuais são determinados, em parte, pelos mesmos conjuntos de genes que influenciam a AOL. Abstract in english The aim of this work was to evaluate the genetic and phenotypic correlations between carcass traits measured by real-time ultrasound and by visual scores, in order to verify the effectiveness of these scores in determining muscularity and carcass fat. Carcass traits measured by real-time ultrasound [...] were longissimus muscle area (LMA) and backfat thickness (BF), obtained between the 12th and 13th ribs, as well as the rump fat thickness (RF). The visual scores for the traits of body structure (E), precocity (P), and muscle (M) were evaluated individually. The genetic and phenotypic parameters were estimated by multivariate analysis, using restricted maximum likelihood methodology. The estimated genetic correlations between LMA and E, P and M were 0.54, 0.58 and 0.61, respectively, indicating that, in the long term, the use of LMA as a selection criterion might produce animals with higher visual scores. Similar genetic correlations were found between both subcutaneous fat measures (BF and RF) and P and M scores. However, genetic correlations between both subcutaneous fat measures and E were close to zero. The phenotypic correlations followed the same trends of their respective genetic correlations. These estimates indicate that the visual scores and LMA are, in part, determined by the same groups of genes.

Marcos Jun Iti, Yokoo; Juliana Nunes, Werneck; Márcio Cinachi, Pereira; Lucia Galvão de, Albuquerque; William, Koury Filho; Roberto Daniel, Sainz; Raysildo Barbosa, Lobo; Fabiano Rodrigues da Cunha, Araujo.

2009-02-01

157

Correlações genéticas entre escores visuais e características de carcaça medidas por ultrassom em bovinos de corte Genetic correlations between visual scores and carcass traits measured by real-time ultrasound in beef cattle  

Directory of Open Access Journals (Sweden)

Full Text Available O objetivo deste trabalho foi estimar correlações genéticas e fenotípicas entre escores visuais e características de carcaça medidas por ultrassom, para verificar a eficácia desses escores na determinação da musculosidade e na avaliação da carcaça. As características de carcaça medidas por ultrassom foram área de olho de lombo (AOL e espessura de gordura subcutânea (EG, mensuradas entre a região da 12ª e 13ª costelas, bem como a espessura de gordura subcutânea na garupa (EGP8. As características de estrutura (E, precocidade (P e musculosidade (M foram avaliadas por meio de escores visuais. Os componentes de covariância usados para estimar as correlações genéticas e fenotípicas foram obtidos pelo método da máxima verossimilhança restrita, em uma análise multicaracterística. As estimativas de correlações genéticas entre AOL e E, P e M foram 0,54, 0,58 e 0,61, respectivamente, e indicaram que, a longo prazo, a utilização da AOL como critério de seleção poderá produzir animais com maiores escores visuais para essas características. As correlações genéticas estimadas entre as espessuras de gordura (EG e EGP8 e os escores P e M apresentaram comportamento semelhante. Entretanto, as correlações genéticas entre as espessuras de gordura (EG e EGP8 e E foram próximas de zero. As correlações fenotípicas seguiram as mesmas tendências das respectivas correlações genéticas. Essas estimativas indicam que os escores visuais são determinados, em parte, pelos mesmos conjuntos de genes que influenciam a AOL.The aim of this work was to evaluate the genetic and phenotypic correlations between carcass traits measured by real-time ultrasound and by visual scores, in order to verify the effectiveness of these scores in determining muscularity and carcass fat. Carcass traits measured by real-time ultrasound were longissimus muscle area (LMA and backfat thickness (BF, obtained between the 12th and 13th ribs, as well as the rump fat thickness (RF. The visual scores for the traits of body structure (E, precocity (P, and muscle (M were evaluated individually. The genetic and phenotypic parameters were estimated by multivariate analysis, using restricted maximum likelihood methodology. The estimated genetic correlations between LMA and E, P and M were 0.54, 0.58 and 0.61, respectively, indicating that, in the long term, the use of LMA as a selection criterion might produce animals with higher visual scores. Similar genetic correlations were found between both subcutaneous fat measures (BF and RF and P and M scores. However, genetic correlations between both subcutaneous fat measures and E were close to zero. The phenotypic correlations followed the same trends of their respective genetic correlations. These estimates indicate that the visual scores and LMA are, in part, determined by the same groups of genes.

Marcos Jun Iti Yokoo

2009-02-01

158

Adrenoleucodistrofia ligada ao X: correlação entre o escore de Loes e parâmetros do tensor de difusão / X-linked adrenoleukodystrophy: correlation between Loes score and diffusion tensor imaging parameters  

Scientific Electronic Library Online (English)

Full Text Available Objetivo: Avaliar a correlação dos parâmetros do tensor de difusão com o escore de Loes e se os parâmetros do tensor de difusão poderiam indicar alterações estruturais precoces. Materiais e Métodos: As medidas do tensor de difusão foram obtidas em 30 exames de 14 pacientes com adrenoleucodistrofia [...] ligada ao X e foram correlacionadas com o escore de Loes. Um grupo controle de 28 pacientes masculinos foi avaliado para estabelecer medidas do tensor de difusão pareadas por idade. Análises estatísticas intra e interobservador foram feitas. Resultados: As medidas do tensor de difusão apresentam forte correlação com o escore de Loes segundo o coeficiente de Pearson (r), com valores de –0,86, 0,89, 0,89 e 0,84 para a fração de anisotropia e difusibilidades média, radial e axial (p Abstract in english Objective: The present study was aimed at evaluating the correlation between diffusion tensor imaging parameters and Loes score as well as whether those parameters could indicate early structural alterations. Materials and Methods: Diffusion tensor imaging measurements were obtained in 30 studies o [...] f 14 patients with X-linked adrenoleukodystrophy and were correlated with Loes scores. A control group including 28 male patients was created to establish agematched diffusion tensor imaging measurements. Inter- and intraobserver statistical analyses were undertaken. Results: Diffusion tensor imaging measurements presented strong Pearson correlation coefficients (r) of –0.86, 0.89, 0.89 and 0.84 for fractional anisotropy and mean, radial and axial diffusivities (p

Sergio Eiji, Ono; Arnolfo de, Carvalho Neto; Emerson Leandro, Gasparetto; Luiz Otávio de Mattos, Coelho; Dante Luiz, Escuissato; Carmem Maria Sales, Bonfim; Lisandro Lima, Ribeiro.

2014-12-01

159

Correlation  

Science.gov (United States)

This chapter will discuss the concept of correlation , which is used in later chapters that will explain the concepts of validity and reliability. Here, the authors introduce the Pearson correlation coefficient, a statistic that is used with ratio

Edwin P. Christmann

2008-11-01

160

Contrasting Probabilistic Scoring Rules  

CERN Document Server

There are several scoring rules that one can choose from in order to score probabilistic forecasting models or estimate model parameters. Whilst it is generally agreed that proper scoring rules are preferable, there is no clear criterion for preferring one proper scoring rule above another. This manuscript compares and contrasts properties of some commonly used proper scoring rules and provides guidance on scoring rule selection. In particular, it is shown that the logarithmic scoring rule prefers erring on the side of caution, whereas the other scoring rules tend to be indifferent to the alternative risky option.

Machete, Reason Lesego

2011-01-01

161

Assessment of lung disease in children with cystic fibrosis using hyperpolarized 3-Helium MRI: comparison with Shwachman score, Chrispin-Norman score and spirometry  

International Nuclear Information System (INIS)

This study assesses the feasibility of hyperpolarized 3-Helium MRI in children with cystic fibrosis (CF) and correlates the findings with standard clinical parameters based on chest radiograph (CXR) and pulmonary function tests (PFT). An uncontrolled, observational study in eighteen children with cystic fibrosis aged 5 - 17 years (median 12.1 years), with different severity of disease was carried out. All subjects underwent routine clinical assessment including PFT and standard auxology; CXR was obtained and Shwachman and Chrispin-Norman scores calculated. Hyperpolarized 3-He magnetic resonance imaging (MRI) was carried out using a spin-exchange polarizer and a whole body 1.5 T scanner. Ventilation distribution images were obtained during a 21-second breath-hold and scored according to previously defined criteria. Spearman's non-parametric correlations test was performed to assess for statistical significance at the p<0.05 level. The children tolerated the procedure well. No desaturation events were observed during 3-He MRI. A significant, albeit moderate, correlation was found between MRI score and FEV1% predicted (r=-0.41; p=0.047) and FVC% predicted (r=-0.42; p=0.04), while there were trends of correlations between Shwachman score and MRI score (r=-0.38; p=0.06) and Shwachman score and FEV1% predicted (r=0.39; p=0.055). The feasibility of hyperpolarized 3-He MRI in children with CF was demonstrated. MRI appears to be able to demonstrate functional lung changes, alto demonstrate functional lung changes, although correlations with routine clinical tests are only moderate to poor. This non-ionising radiation technique could be useful for monitoring lung disease and assessing therapy in this patient population. (orig.)

162

Assessment of lung disease in children with cystic fibrosis using hyperpolarized 3-Helium MRI: comparison with Shwachman score, Chrispin-Norman score and spirometry  

Energy Technology Data Exchange (ETDEWEB)

This study assesses the feasibility of hyperpolarized 3-Helium MRI in children with cystic fibrosis (CF) and correlates the findings with standard clinical parameters based on chest radiograph (CXR) and pulmonary function tests (PFT). An uncontrolled, observational study in eighteen children with cystic fibrosis aged 5 - 17 years (median 12.1 years), with different severity of disease was carried out. All subjects underwent routine clinical assessment including PFT and standard auxology; CXR was obtained and Shwachman and Chrispin-Norman scores calculated. Hyperpolarized 3-He magnetic resonance imaging (MRI) was carried out using a spin-exchange polarizer and a whole body 1.5 T scanner. Ventilation distribution images were obtained during a 21-second breath-hold and scored according to previously defined criteria. Spearman's non-parametric correlations test was performed to assess for statistical significance at the p<0.05 level. The children tolerated the procedure well. No desaturation events were observed during 3-He MRI. A significant, albeit moderate, correlation was found between MRI score and FEV1% predicted (r=-0.41; p=0.047) and FVC% predicted (r=-0.42; p=0.04), while there were trends of correlations between Shwachman score and MRI score (r=-0.38; p=0.06) and Shwachman score and FEV1% predicted (r=0.39; p=0.055). The feasibility of hyperpolarized 3-He MRI in children with CF was demonstrated. MRI appears to be able to demonstrate functional lung changes, although correlations with routine clinical tests are only moderate to poor. This non-ionising radiation technique could be useful for monitoring lung disease and assessing therapy in this patient population. (orig.)

Beek, Edwin J.R. van [University of Sheffield, Unit of Academic Radiology, Sheffield (United Kingdom); University of Iowa, Department of Radiology, Carver College of Medicine, Iowa City (United States); University of Iowa, Department of Radiology, Iowa City, IA (United States); Hill, Catherine; Woodhouse, Neil; Fichele, Stanislao; Fleming, Sally; Wild, Jim M. [University of Sheffield, Unit of Academic Radiology, Sheffield (United Kingdom); Howe, Bridget; Bott, Sandra; Taylor, Christopher J. [University of Sheffield, Academic Unit of Child Health, Sheffield (United Kingdom)

2007-04-15

163

Correlação de três variáveis na descrição da permeabilidade nasal (HD, MCA, escala NOSE) de pacientes saudáveis / Correlation of three variables describing nasal patency (HD, MCA, NOSE score) in healthy subjects  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese Rinoresistometria e rinometria acústica são dois métodos utilizados na avaliação da função respiratória nasal. Ambos utilizam variáveis diferentes para descrever a permeabilidade nasal: o diâmetro hidráulico, HD, na rinoresistometria; e as áreas mínimas da seção transversal, MCA1 (istmo nasal) e MCA [...] 2 (cabeça do corneto inferior e corpo cavernoso do septo nasal), na rinometria acústica. OBJETIVO: Analisar a relação entre HD e MCA em pacientes sem afecções nasais e identificar se tais variáveis objetivas apresentam correlação com a escala NOSE, uma ferramenta validada para avaliar a percepção subjetiva de permeabilidade nasal. MÉTODO: Coleta estruturada dos dados de 24 indivíduos saudáveis sem afecções nasais. RESULTADOS: Correlações estatisticamente significativas de fracas a moderadas foram identificadas entre HD e MCA2 antes do descongestionamento. Foi identificada correlação moderada entre HD, MCA2 e escala NOSE no lado mais estreito. CONCLUSÃO: Na avaliação de permeabilidade nasal, parece ser recomendável determinar HD, MCA1 e MCA2, bem como uma variável subjetiva como a escala NOSE, que não aparentam ser variáveis completamente redundantes. Estudos futuros devem avaliar a correlação destas variáveis em pacientes com afecções nasais. Abstract in english Rhinoresistometry and acoustic rhinometry are two established apparative methods to objectify the respiratory function of the nose. Both methods use different variables to describe nasal patency: "hydraulic diameter", HD, in rhinoresistometry, and "minimal cross-sectional area", MCA1 (nasal isthmus) [...] and MCA2 (head of the inferior turbinate and cavernous body of the nasal septum), in acoustic rhinometry. OBJECTIVE: This study analyzes the mutual correlation of HD and MCA as a pilot study in patients without nasal pathologies. Additionally, we investigated if these objective variables correlate with the NOSE score, a validated tool to measure subjective perception of nasal patency. METHOD: Planned data collection in a collective of 24 healthy subjects without nasal pathologies. RESULTS: Statistically significant, weak to moderate correlations were found between HD and MCA2 before decongestion. A moderate correlation was found between both HD and MCA2 and the NOSE score on the narrower side. CONCLUSION: In the assessment of nasal patency, it seems advisable to determine HD, MCA1 and MCA2, but also a subjective variable such as the NOSE score, which all seem to be not fully redundant variables. In further studies, the correlation of the variables should be assessed in patients with nasal pathologies.

Thomas, Braun; Maria, Rich; Matthias F., Kramer.

2013-06-01

164

Correlação de três variáveis na descrição da permeabilidade nasal (HD, MCA, escala NOSE de pacientes saudáveis Correlation of three variables describing nasal patency (HD, MCA, NOSE score in healthy subjects  

Directory of Open Access Journals (Sweden)

Full Text Available Rinoresistometria e rinometria acústica são dois métodos utilizados na avaliação da função respiratória nasal. Ambos utilizam variáveis diferentes para descrever a permeabilidade nasal: o diâmetro hidráulico, HD, na rinoresistometria; e as áreas mínimas da seção transversal, MCA1 (istmo nasal e MCA2 (cabeça do corneto inferior e corpo cavernoso do septo nasal, na rinometria acústica. OBJETIVO: Analisar a relação entre HD e MCA em pacientes sem afecções nasais e identificar se tais variáveis objetivas apresentam correlação com a escala NOSE, uma ferramenta validada para avaliar a percepção subjetiva de permeabilidade nasal. MÉTODO: Coleta estruturada dos dados de 24 indivíduos saudáveis sem afecções nasais. RESULTADOS: Correlações estatisticamente significativas de fracas a moderadas foram identificadas entre HD e MCA2 antes do descongestionamento. Foi identificada correlação moderada entre HD, MCA2 e escala NOSE no lado mais estreito. CONCLUSÃO: Na avaliação de permeabilidade nasal, parece ser recomendável determinar HD, MCA1 e MCA2, bem como uma variável subjetiva como a escala NOSE, que não aparentam ser variáveis completamente redundantes. Estudos futuros devem avaliar a correlação destas variáveis em pacientes com afecções nasais.Rhinoresistometry and acoustic rhinometry are two established apparative methods to objectify the respiratory function of the nose. Both methods use different variables to describe nasal patency: "hydraulic diameter", HD, in rhinoresistometry, and "minimal cross-sectional area", MCA1 (nasal isthmus and MCA2 (head of the inferior turbinate and cavernous body of the nasal septum, in acoustic rhinometry. OBJECTIVE: This study analyzes the mutual correlation of HD and MCA as a pilot study in patients without nasal pathologies. Additionally, we investigated if these objective variables correlate with the NOSE score, a validated tool to measure subjective perception of nasal patency. METHOD: Planned data collection in a collective of 24 healthy subjects without nasal pathologies. RESULTS: Statistically significant, weak to moderate correlations were found between HD and MCA2 before decongestion. A moderate correlation was found between both HD and MCA2 and the NOSE score on the narrower side. CONCLUSION: In the assessment of nasal patency, it seems advisable to determine HD, MCA1 and MCA2, but also a subjective variable such as the NOSE score, which all seem to be not fully redundant variables. In further studies, the correlation of the variables should be assessed in patients with nasal pathologies.

Thomas Braun

2013-06-01

165

Rape Myth Acceptance, Hypermasculinity, and SAT Scores as Correlates of Moral Development: Understanding Sexually Aggressive Attitudes in First-Year College Men  

Science.gov (United States)

Male perpetrated sexual aggression has long been recognized as a serious problem on college campuses. The purpose of this multiple regression correlation study was to assess the relationship between levels of moral development (measured by the Defining Issues Test) and the degree to which first-year college men (N = 161) ascribed to rape…

Tatum, Jerry L.; Foubert, John D.

2009-01-01

166

Reliability, validity, and cut scores of the south oaks gambling screen (SOGS) for Chinese.  

Science.gov (United States)

We examined the reliability, validity, and classification accuracy of the South Oaks Gambling Screen (SOGS) when adopted for use in Chinese. The DSM-IV criteria for pathological gambling served as the standard against which the classification accuracy of the SOGS was tested. A total of 283 Chinese adults in the community and 94 Chinese treatment-seeking gamblers were recruited. The internal reliability of the SOGS was satisfactory for the general sample and acceptable for the gambling sample. The SOGS was correlated with the DSM-IV criteria items as well as psychosocial and gambling-related problems. Relative to the DSM-IV criteria, the SOGS tended to overestimate the number of pathological gamblers in both samples. In general, we were relatively confident that individuals were not pathological gamblers if the SOGS scores were between 0 and 4 and were pathological gamblers if the SOGS were between 11 and 20. There was about 50-50 chance of being pathological gamblers if the SOGS scores were between 8 and 10. However, the probability of individuals being pathological gamblers was about 0.30 if the SOGS scores were between 5 and 7. We proposed a SOGS cut score of 8 to screen for probable pathological gambling in Chinese societies. PMID:19680794

Tang, Catherine So-kum; Wu, Anise M S; Tang, Joe Y C; Yan, Elsie C W

2010-03-01

167

Test Scoring [book review].  

Science.gov (United States)

This book discusses how to obtain test scores and, in particular, how to obtain test scores from tests that consist of a combination of multiple choice and open-ended questions. The strength of the book is that scoring solutions are presented for a diversity of real world scoring problems. (SLD)

Meijer, Rob R.

2003-01-01

168

Genetic polymorphisms of the BMAP-28 and MASP-2 genes and their correlation with the somatic cell score in Chinese Holstein cattle.  

Science.gov (United States)

DNA sequencing, nested polymerase chain reaction (PCR), and PCR-restriction fragment length polymorphism were used to investigate mutations in the coding regions of the bovine myeloid antimicrobial peptide-28 (BMAP-28) and mannan-binding lectin-associated serine protease-2 (MASP-2) genes in 249 Chinese Holstein dairy cows. The associations between the polymorphisms and somatic cell score (SCS) were analyzed to determine the potential of these genes as genetic markers for breeding mastitis-resistant dairy cattle. The results revealed a C-86G synonymous mutation in the BMAP-28 gene that caused no alteration in the amino acid sequence. G553A mutation was found in the MASP-2 gene that led to the substitution of glycine with serine. The chi-square test showed that the G553A mutation was in Hardy-Weinberg equilibrium in the Chinese Holstein dairy cows, whereas the C-86G mutation was not. The variance analysis of the influence of group loci and different genotypes on the SCS showed that the SCS of genotype CC was significantly lower than those of genotypes CG and GG (P mutation, and that the SCS of genotype GG was significantly lower than those of genotypes GA and AA (P mutation. Genotype combination analysis showed that the combination of the BMAP-28 genotype CC and the MASP-2 genotype GG was the best one, in which the SCS was significantly lower than those in the other combinations. Thus, this combination might be useful as a molecular and genetic marker of mastitis in Chinese Holstein dairy cows. PMID:25729929

Wu, J; Bai, J Y; Li, L; Huang, S; Li, C M; Wang, G L

2015-01-01

169

Adrenoleucodistrofia ligada ao X: correlação entre o escore de Loes e parâmetros do tensor de difusão / X-linked adrenoleukodystrophy: correlation between Loes score and diffusion tensor imaging parameters  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese Objetivo: Avaliar a correlação dos parâmetros do tensor de difusão com o escore de Loes e se os parâmetros do tensor de difusão poderiam indicar alterações estruturais precoces. Materiais e Métodos: As medidas do tensor de difusão foram obtidas em 30 exames de 14 pacientes com adrenoleucodistrofi [...] a ligada ao X e foram correlacionadas com o escore de Loes. Um grupo controle de 28 pacientes masculinos foi avaliado para estabelecer medidas do tensor de difusão pareadas por idade. Análises estatísticas intra e interobservador foram feitas. Resultados: As medidas do tensor de difusão apresentam forte correlação com o escore de Loes segundo o coeficiente de Pearson (r), com valores de –0,86, 0,89, 0,89 e 0,84 para a fração de anisotropia e difusibilidades média, radial e axial (p Abstract in english Objective: The present study was aimed at evaluating the correlation between diffusion tensor imaging parameters and Loes score as well as whether those parameters could indicate early structural alterations. Materials and Methods: Diffusion tensor imaging measurements were obtained in 30 studies [...] of 14 patients with X-linked adrenoleukodystrophy and were correlated with Loes scores. A control group including 28 male patients was created to establish agematched diffusion tensor imaging measurements. Inter- and intraobserver statistical analyses were undertaken. Results: Diffusion tensor imaging measurements presented strong Pearson correlation coefficients (r) of –0.86, 0.89, 0.89 and 0.84 for fractional anisotropy and mean, radial and axial diffusivities (p

Sergio Eiji, Ono; Arnolfo de, Carvalho Neto; Emerson Leandro, Gasparetto; Luiz Otávio de Mattos, Coelho; Dante Luiz, Escuissato; Carmem Maria Sales, Bonfim; Lisandro Lima, Ribeiro.

2014-12-01

170

A Study of Relationships between the CI Scores (E-C) of High-score & Low-score Groups and Their Language Learning Strategies  

OpenAIRE

This paper investigates the relationships between language learning strategies and consecutive interpretation (CI) scores (E-C) of 120 English major students in China through a quantitative study. The analysis shows that there exist significant differences of using meta-cognitive strategy and cognitive strategy between high-score group and low-score group, sub-CI scores are positively correlated with the two strategies, and meta-cognitive strategy can positively predict the total scores. This...

Jianjun Liu

2011-01-01

171

Is the FAMACHA chart suitable for every breed? Correlations between FAMACHA scores and different traits of mucosa colour in naturally parasite infected sheep breeds.  

Science.gov (United States)

Infections with gastrointestinal nematodes, in particular Haemonchus contortus, are worldwide one of the most important factors causing high economic losses in sheep production. Different methods for detecting infections with H. contortus have been described, such as, e.g. the FAMACHA system, which categorises the colour of the conjunctivae from red to pale. When H. contortus is not the predominant parasite, the FAMACHA chart might not be suitable to detect nematode infections, because of the lack of a blood feeding parasite. Otherwise breed-specific differences in the colour of the mucosa could be responsible for the limitations of the FAMACHA system. The aim of the study was to compare different methods of measuring mucosa colour in the German sheep breeds Black Head Mutton (BH) and Leine sheep (LE). In a total of 232 6-months-old lambs, the colour of mucosa was measured using the FAMACHA chart (conjunctivae) as well as the colour analyser Minolta Chroma Meter CR-200b (gingivae). Faeces and blood samples were taken at the same time to determine faecal egg counts per gram faeces (FEC) and the packed cell volume (PCV), respectively. Lambs grazed on contaminated pastures and no anthelmintic treatment was used. Lambs were moderately infected with gastrointestinal nematodes with no significant difference between the two breeds (P>0.05). The prevalence of H. contortus was 23%, based on larvae differentiation of coproculture. There was no significant correlation between FEC and PCV, nor FEC and FAMACHA (P>0.05). Significant differences (P or =0.27l/l), as shown by significant correlation coefficients between PCV and Chroma and HA, respectively. It can be concluded, that the measurement of mucosa colour with a colour analyser is more sensitive in detecting anaemic states in sheep, compared to the FAMACHA chart. However, because the colour analyser is not suited for measurements in the field, an adaptation of the FAMACHA colour scales for different sheep breeds might be required. PMID:19699035

Moors, Eva; Gauly, Matthias

2009-12-01

172

Dual-energy X-ray absorptiometry diagnostic discordance between Z-scores and T-scores in young adults.  

LENUS (Irish Health Repository)

Diagnostic criteria for postmenopausal osteoporosis using central dual-energy X-ray absorptiometry (DXA) T-scores have been widely accepted. The validity of these criteria for other populations, including premenopausal women and young men, has not been established. The International Society for Clinical Densitometry (ISCD) recommends using DXA Z-scores, not T-scores, for diagnosis in premenopausal women and men aged 20-49 yr, though studies supporting this position have not been published. We examined diagnostic agreement between DXA-generated T-scores and Z-scores in a cohort of men and women aged 20-49 yr, using 1994 World Health Organization and 2005 ISCD DXA criteria. Four thousand two hundred and seventy-five unique subjects were available for analysis. The agreement between DXA T-scores and Z-scores was moderate (Cohen\\'s kappa: 0.53-0.75). The use of Z-scores resulted in significantly fewer (McNemar\\'s p<0.001) subjects diagnosed with "osteopenia," "low bone mass for age," or "osteoporosis." Thirty-nine percent of Hologic (Hologic, Inc., Bedford, MA) subjects and 30% of Lunar (GE Lunar, GE Madison, WI) subjects diagnosed with "osteoporosis" by T-score were reclassified as either "normal" or "osteopenia" when their Z-score was used. Substitution of DXA Z-scores for T-scores results in significant diagnostic disagreement and significantly fewer persons being diagnosed with low bone mineral density.

Carey, John J

2009-01-01

173

Dual-energy X-ray absorptiometry diagnostic discordance between Z-scores and T-scores in young adults.  

Science.gov (United States)

Diagnostic criteria for postmenopausal osteoporosis using central dual-energy X-ray absorptiometry (DXA) T-scores have been widely accepted. The validity of these criteria for other populations, including premenopausal women and young men, has not been established. The International Society for Clinical Densitometry (ISCD) recommends using DXA Z-scores, not T-scores, for diagnosis in premenopausal women and men aged 20-49 yr, though studies supporting this position have not been published. We examined diagnostic agreement between DXA-generated T-scores and Z-scores in a cohort of men and women aged 20-49 yr, using 1994 World Health Organization and 2005 ISCD DXA criteria. Four thousand two hundred and seventy-five unique subjects were available for analysis. The agreement between DXA T-scores and Z-scores was moderate (Cohen's kappa: 0.53-0.75). The use of Z-scores resulted in significantly fewer (McNemar's p<0.001) subjects diagnosed with "osteopenia," "low bone mass for age," or "osteoporosis." Thirty-nine percent of Hologic (Hologic, Inc., Bedford, MA) subjects and 30% of Lunar (GE Lunar, GE Madison, WI) subjects diagnosed with "osteoporosis" by T-score were reclassified as either "normal" or "osteopenia" when their Z-score was used. Substitution of DXA Z-scores for T-scores results in significant diagnostic disagreement and significantly fewer persons being diagnosed with low bone mineral density. PMID:19195620

Carey, John J; Delaney, Miriam F; Love, Thomas E; Cromer, Barbara A; Miller, Paul D; Richmond, Bradford J; Manilla-McIntosh, Martha; Lewis, Steven A; Thomas, Charles L; Licata, Angelo A

2009-01-01

174

2011 Y?l? Yönetici Atama ve Yer De?i?tirme Yönetme?i’nin ?çeri?ine ve Puanlama Ölçütlerine ?li?kin Yönetici Görü?lerinin ?ncelenmesi Investigation of Manager Opinions on the Content and Scoring Criteria of the 2011 Manager Appointment and Rotation Regulations  

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Full Text Available Purpose: This study aims at determining the opinions of managersrelating to the Manager Appointment and Rotation Regulations dated2011, the scoring criteria included in the regulations and the troublesexperienced throughout the implementation process of the regulations.Method: In this research, a qualitative approach was adopted sothat the issue can be examined thoroughly. In this research, thephenomenological pattern was employed. In the research, participantswere determined by way of sampling for maximum diversity-one of theintentional sampling methods. The study group of the research consistsof 8 managers holding Office in the city X (pseudonym. Terms of Officeof the participants varies between 25 and 8 years. Semi-structuredinterview form was used as data collection tools in the research. All theinterviews were recorded on a tape recorder throughout the research. A240-minute interview was had within the scope of the research; the taperecording was computerized through the Microsoft Word processingprogram as raw data without being subjected to any screening.Line by line analysis described by Patton, (2002 was employed todescribe opinions expressed clearly and directly or implied in anindirect manner by the participants on the aim of the study withoutmanipulating them. Inductive descriptive analysis, content analysis andthe constant comparison technique was used in the interpretation ofthe interview data. The descriptive analysis project is made up of fourmain stages, namely, building up the thematic framework, processingdata according to the thematic framework, identifying the findings andinterpreting the findings.During content analysis, on the other hand, the data was dividedinto parts first and then these parts were investigated and compared.Later, meaningful concepts were built from these parts and the codesevoking the same concepts were grouped under a joint category. In thefinal stage, content integrity was derived from the themes stemmingfrom the data and interpreted.While developing an interview form, a conceptual frameworkrelating to the subject matter was formed by investigating the relatedbody of literature for the purposes of increasing credibility/ internalvalidity of the research. Each stage of the research process wasprovided to the reader in a detailed manner so that thetransferability/external validity of the research could be insured. Theresearcher has watched over to write his research report in detail andtried to present detailed descriptions in the findings part.All the data obtained throughout the research process wasevaluated and separately coded by the researcher and an instructor,who has a command of qualitative research methods and a consensuswas reached on the codings in general terms. Results: As a result of analysis of the data, three main subjects, namely, 1. Evaluations relating to the appointment and change of Office of managers, 2. Evaluations relating to the content of the Manager Appointment and Change of Office Regulations and to the scoring principles, 3. Evaluations relating to compulsory rotation appeared.As a result of the story, it was concluded that the belief that the awards (certificates of appreciation and high achievement granted by the Ministry of National Education central organization and provincial organizations and by the related civilian authority are not offered based on merits, justice and qualification and in line with objective criteria dominated the participants and based on this idea, they had the idea that scoring of these awards in the manager appointment process may lead to unfair competition and injustice.It was found out in the study that the participants objected not to the scoring of the awards in the appointment of manager; just to the contrary, they argued against the scoring of these awards in the manager appointment process based on the idea that the awards granted were not given according to objective criteria.It was observed that the participants believing that there is a relationship between the term of Office and experience an

Selçuk Be?ir DEM?R

2013-07-01

175

A comparative study of conservation and variation scores  

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Full Text Available Abstract Background Conservation and variation scores are used when evaluating sites in a multiple sequence alignment, in order to identify residues critical for structure or function. A variety of scores are available today but it is not clear how different scores relate to each other. Results We applied 25 conservation and variation scores to alignments from the Catalytic Site Atlas (CSA. We calculated distances among scores based on correlation coefficients, and constructed a dendrogram of the scores by average linking cluster analysis. The cluster analysis showed that most scores fall into one of two groups--substitution matrix based group and frequency based group respectively. We also evaluated the scores' performance in predicting catalytic sites and found that frequency based scores generally perform best. Conclusions Conservation and variation scores can be classified into mainly two large groups. When using a score to predict catalytic sites, frequency based scores that also consider a background distribution are most successful.

Toh Hiroyuki

2010-07-01

176

Memory malingering: evaluating WMT criteria.  

Science.gov (United States)

The Word Memory Test (WMT) has been considered one of the best assessment tools for assessing memory malingering in spite of some reported false-positive results. Our goal was to examine the sensitivity and specificity of Green's 2003 criteria for memory malingering using a Portuguese adaptation of the WMT. We applied the WMT to three groups of participants, including 20 healthy subjects asked to simulate memory impairment, 29 healthy adults asked to produce their best performance, and 21 patients with the diagnosis of mild cognitive impairment (MCI). Using Green's 2003 criteria, based on scores below cutoffs on the easy subtests, 67% of the MCI patients were classified as "poor effort." However, the sensitivity and specificity of the diagnosis could be raised to 95% using an alternative set of criteria, relying on comparisons between easy and hard subtest scores. We conclude that Green's original criteria based on easy subtest scores alone seem to be of low specificity for the diagnosis of memory impairment simulation, but the WMT is a good instrument for identifying simulation if the alternative criteria are applied. PMID:20799108

Martins, Mauricio; Martins, Isabel P

2010-07-01

177

Analysis of Project Success Criteria in the Nigerian Construction Industry  

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Full Text Available This paper examined the relative importance of the project success criteria in the Nigerian construction industry. It also determined the correlation among the project success criteria. Based on the literatures reviewed, the study proposed a framework for measuring project success in the construction industry. The respondents for the study were the government, private clients, consultants and contractors. Three hundred copies of questionnaires were distributed to capture data on the subject, but only 86 were returned and used for the study. The paper captured respondents that are resident in Lagos state, Nigeria and chosen by convenience from selected organizations used for the study. The data were analysed with SPSS 16 through the use of frequencies, mean scores, factor analysis and correlation. Factor analysis was employed because the mean scores showed that all the project success criteria were at least important. Nine principal components were finally merged into 4 through the factor analysis using the Varimax rotation with Keiser normalization. The study found out that all the project success criteria were important but their level of importance differs according to the factor analysis carried out. Therefore, it was concluded that there are four major components of construction project success in Nigeria- user-related factors, professionals’ factors, organisational factors and other minor factors. The minor factors were found to be related to both organizations and projects but were not highly rated by respondents for determining construction project success. The study also concludes that project success criteria goes beyond meeting cost, time and quality target, it includes users’ satisfaction, professionals’ fulfilment and achievement of organizational goals. The recommendation of the study was that for construction projects to be successful, attention must be paid to users’ related factors, professionals’ factors and organizations’ factors.

Oluwaseun Sunday Dosumu

2013-02-01

178

Prediction of bronchopulmonary dysplasia by chest radiographic scoring system at seven days of age  

International Nuclear Information System (INIS)

Recent trials of preventive dexamethasone therapy in preterm neonates at high risk of developing bronchopulmonary dysplasia (BPD) have required the objective criteria for prediction of BPD in the early neonatal period. The purpose of this study is to determine whether a chest radiographic scoring system at 7 days of age can be used to predict BPD. Chest radiographs taken at 7 days and 28 days of age in 59 preterm neonates(gestational age of less than 33 weeks) were scored prospectively according to the consensus of two radiologists. The 7-day radiographs were scored according to a system derived from Yuksel's method:endotracheal tube insertion, degree of lung inflation, lung opacification, interstitial changes and cardiomegaly were measured. The radiographs taken at 28 days were scored according to a modification of Toce's method. The BPD group was defined as consisting of patients who needed oxygen therapy for more than 28 days and showed abnormality on chest radiographs. Scores were analysed to determine whether there were any statistical differences between the BPD and non-BPD groups, whether there was a significant correlation between scores at 7 days and 28 days, and whether there was any relationship between scores at 7 days of age and the development of BPD. We tried to determine which factors, as indicated by the scores at 7 days, significantly contributed to the development of BPD. The mean scores at 7 days of age in the BPD group (n=18) were 4.3±1.5 (2-7), the BPD group (n=18) were 4.3±1.5 (2-7), and those in the non-BPD group (n=41) were 2.2±1.2 (0-4). The differences were statistically significant (p<.0001). Significant correlation was found between scores at 7 days and at 28 days of age(r:0.57, p<.0001). Analysis showed that endotracheal tube insertion, cardiomegaly, and degree of interstitial change, as seen on radiographs at 7 days, were factors which significantly contributed to the development of BPD (p<0.05 each). All neonates with a score of 5 or more developed BPD (7/7), while those with a score of less than 2 did not (0/11). The chest radiographic scoring system used at 7 days of age can be helpful in predicting the development of BPD. We believe that this system can be used to indicate the need for early preventive steroid therapy

179

Prediction of bronchopulmonary dysplasia by chest radiographic scoring system at seven days of age  

Energy Technology Data Exchange (ETDEWEB)

Recent trials of preventive dexamethasone therapy in preterm neonates at high risk of developing bronchopulmonary dysplasia (BPD) have required the objective criteria for prediction of BPD in the early neonatal period. The purpose of this study is to determine whether a chest radiographic scoring system at 7 days of age can be used to predict BPD. Chest radiographs taken at 7 days and 28 days of age in 59 preterm neonates(gestational age of less than 33 weeks) were scored prospectively according to the consensus of two radiologists. The 7-day radiographs were scored according to a system derived from Yuksel's method:endotracheal tube insertion, degree of lung inflation, lung opacification, interstitial changes and cardiomegaly were measured. The radiographs taken at 28 days were scored according to a modification of Toce's method. The BPD group was defined as consisting of patients who needed oxygen therapy for more than 28 days and showed abnormality on chest radiographs. Scores were analysed to determine whether there were any statistical differences between the BPD and non-BPD groups, whether there was a significant correlation between scores at 7 days and 28 days, and whether there was any relationship between scores at 7 days of age and the development of BPD. We tried to determine which factors, as indicated by the scores at 7 days, significantly contributed to the development of BPD. The mean scores at 7 days of age in the BPD group (n=18) were 4.3{+-}1.5 (2-7), and those in the non-BPD group (n=41) were 2.2{+-}1.2 (0-4). The differences were statistically significant (p<.0001). Significant correlation was found between scores at 7 days and at 28 days of age(r:0.57, p<.0001). Analysis showed that endotracheal tube insertion, cardiomegaly, and degree of interstitial change, as seen on radiographs at 7 days, were factors which significantly contributed to the development of BPD (p<0.05 each). All neonates with a score of 5 or more developed BPD (7/7), while those with a score of less than 2 did not (0/11). The chest radiographic scoring system used at 7 days of age can be helpful in predicting the development of BPD. We believe that this system can be used to indicate the need for early preventive steroid therapy.

Choi, Yun Sun; Kim, Woo Sun; Kim, In One; Choi, Jung Hwan; Yeon, Kyung Mo; Yun, Chong Ku [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

1997-03-01

180

Algorithmic scoring models  

OpenAIRE

This article is devoted to the analysis of different credit scoring modeling techniques which can be used for the large datasets processing. Credit scoring is a basis of the banking system. There are lots if information gathered in the banks’ databases which should be used in the scoring. This article describes the basic methods and technologies of scoring models development for the risk management of the banking system.

Nurlybayeva, K.; Balakayeva, G.

2013-01-01

181

Algorithmic scoring models  

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Full Text Available This article is devoted to the analysis of different credit scoring modeling techniques which can be used for the large datasets processing. Credit scoring is a basis of the banking system. There are lots if information gathered in the banks’ databases which should be used in the scoring. This article describes the basic methods and technologies of scoring models development for the risk management of the banking system.

K. Nurlybayeva

2013-01-01

182

Various criteria in the evaluation of biomedical named entity recognition  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Text mining in the biomedical domain is receiving increasing attention. A key component of this process is named entity recognition (NER. Generally speaking, two annotated corpora, GENIA and GENETAG, are most frequently used for training and testing biomedical named entity recognition (Bio-NER systems. JNLPBA and BioCreAtIvE are two major Bio-NER tasks using these corpora. Both tasks take different approaches to corpus annotation and use different matching criteria to evaluate system performance. This paper details these differences and describes alternative criteria. We then examine the impact of different criteria and annotation schemes on system performance by retesting systems participated in the above two tasks. Results To analyze the difference between JNLPBA's and BioCreAtIvE's evaluation, we conduct Experiment 1 to evaluate the top four JNLPBA systems using BioCreAtIvE's classification scheme. We then compare them with the top four BioCreAtIvE systems. Among them, three systems participated in both tasks, and each has an F-score lower on JNLPBA than on BioCreAtIvE. In Experiment 2, we apply hypothesis testing and correlation coefficient to find alternatives to BioCreAtIvE's evaluation scheme. It shows that right-match and left-match criteria have no significant difference with BioCreAtIvE. In Experiment 3, we propose a customized relaxed-match criterion that uses right match and merges JNLPBA's five NE classes into two, which achieves an F-score of 81.5%. In Experiment 4, we evaluate a range of five matching criteria from loose to strict on the top JNLPBA system and examine the percentage of false negatives. Our experiment gives the relative change in precision, recall and F-score as matching criteria are relaxed. Conclusion In many applications, biomedical NEs could have several acceptable tags, which might just differ in their left or right boundaries. However, most corpora annotate only one of them. In our experiment, we found that right match and left match can be appropriate alternatives to JNLPBA and BioCreAtIvE's matching criteria. In addition, our relaxed-match criterion demonstrates that users can define their own relaxed criteria that correspond more realistically to their application requirements.

Lin Yu-Chun

2006-02-01

183

Finishing precocity visual score and genetic associations with growth traits in Angus beef cattle.  

Science.gov (United States)

Finishing precocity visual score selection was adopted to estimate the time from birth to reach slaughter age. This study estimated (co)variance components and genetic correlations for the finishing precocity score at weaning (WP) and yearling (YP) stages by using daily weight gain (BWG = from birth to weaning; WYG = from weaning to yearling) and speed of weight gain (BWR = from birth to weaning; WYR = from weaning to yearling) as support for a genetic evaluation program for Angus beef cattle. Genetic parameters were estimated using Bayesian inference, considering multi-trait analysis and assuming a nonlinear model for WP and YP and linear model for all other traits. Direct heritability estimates were 0.17 (WP), 0.19 (YP), 0.15 (BWG), 0.16 (WYG), 0.15 (BWR), and 0.16 (WYR). The genetic correlation between the finishing precocity score at two ages (weaning and yearling) was 0.61. Positive and moderate genetic correlations were obtained between WP and BWG (0.47) and WP and BWR (0.46). In contrast, negative and low genetic associations were estimated between WP and yearling growth traits (-0.16, WYG; -0.15, WYR). Genetic correlations between YP and other traits were positive 0.29 (BWG), 0.28 (BWR), 0.48 (WYG), and 0.47 (WYR). The selection response for the finishing precocity score at weaning and yearling ages would be low. Selection to increase WP and YP should result in favorable genetic changes in daily weight gains as a correlated response. Therefore, to obtain animals suited for beef cattle production systems, finishing precocity score and growth traits should be considered as selection criteria. PMID:25299089

Everling, D M; Bresolin, T; Rorato, P R N; Araujo, R O; Boligon, A A; Weber, T; Dornelles, M A; Campos, L T

2014-01-01

184

Interpreting force concept inventory scores: Normalized gain and SAT scores  

Directory of Open Access Journals (Sweden)

Full Text Available Preinstruction SAT scores and normalized gains (G on the force concept inventory (FCI were examined for individual students in interactive engagement (IE courses in introductory mechanics at one high school (N=335 and one university (N=292 , and strong, positive correlations were found for both populations ( r=0.57 and r=0.46 , respectively. These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawson’s Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of students’ cognitive skills, as measured either by the SAT or by Lawson’s test. While Lawson’s test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of students’ reasoning abilities. Knowing the students’ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve students’ cognitive level.

Jeffrey J. Steinert

2007-05-01

185

Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF)predictors of police officer problem behavior and collateral self-report test scores.  

Science.gov (United States)

The current study examined the predictive validity of Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF; Ben-Porath & Tellegen, 2008/2011) scores in police officer screenings. We utilized a sample of 712 police officer candidates (82.6% male) from 2 Midwestern police departments. The sample included 426 hired officers, most of whom had supervisor ratings of problem behaviors and human resource records of civilian complaints. With the full sample, we calculated zero-order correlations between MMPI-2-RF scale scores and scale scores from the California Psychological Inventory (Gough, 1956) and Inwald Personality Inventory (Inwald, 2006) by gender. In the hired sample, we correlated MMPI-2-RF scale scores with the outcome data for males only, owing to the relatively small number of hired women. Several scales demonstrated meaningful correlations with the criteria, particularly in the thought dysfunction and behavioral/externalizing dysfunction domains. After applying a correction for range restriction, the correlation coefficient magnitudes were generally in the moderate to large range. The practical implications of these findings were explored by means of risk ratio analyses, which indicated that officers who produced elevations at cutscores lower than the traditionally used 65 T-score level were as much as 10 times more likely than those scoring below the cutoff to exhibit problem behaviors. Overall, the results supported the validity of the MMPI-2-RF in this setting. Implications and limitations of this study are discussed. (PsycINFO Database Record (c) 2015 APA, all rights reserved). PMID:25383586

Tarescavage, Anthony M; Fischler, Gary L; Cappo, Bruce M; Hill, David O; Corey, David M; Ben-Porath, Yossef S

2015-03-01

186

Criteria for the recognition and correlation of sandstone units in the Precambrian and Paleozoic-Mesozoic clastic sequence in the near east  

Science.gov (United States)

A systematic study of the Precambrian and Paleozoic-Mesozoic clastic sequences (Nubian Sandstone) in Israel and Sinai, and a comparative analysis of its stratigraphy in neighbouring countries, has shown that besides the conventional criteria of subdivision (lithology, field appearance, photogeological features, fossil content), additional criteria can be applied, which singly or in mutual conjuction enable the recognition of widespread units and boundaries. These criteria show lateral constancy, and recurrence of a similar vertical sequence over great distances, and are therefore acceptable for the identification of synchronous, region-wide sedimentary units (and consequently, major unconformities). They also enable, once the units are established, to identify detached (not in situ) samples, samples from isolated or discontinous outcrops, borehole material or archive material. The following rock properties were tested and found to be usefuls in stratigraphic interpretation, throughout large distribution areas of the clastic sequence: Landscape, which is basically the response of a particular textural-chemic al aggregate to atmospheric weathering. Characteristic outcrop feature — styles of roundness or massivity, fissuring or fliatin, slope profile, bedding — express a basic uniformity of these platform-type clastics. Colors are often stratigraphically constant over hundreds of kilometers, through various climates and topographies, and express some intrinsic unity of the rock bodies. Grain size and sorting, when cross-plotted, enable to differentiate existing unit. The method requires the analysis of representative numbers of samples. Vertical trends of median grain size and sorting show reversals, typically across unconformities. Feldstar content diminishes from 15-50% in Precambrian-Paleozoic rocks to a mere 5% or less in Mesozoic sandstones — a distinctive regionwide time trend. Dominance of certain feldstar types characterizes Precambrian and Paleozoic units. Clay minerals, though subordinate, characterize certain units. Illite is usually the dominant clay mineral in the Precambrain-Paleozoic sediments, showing different degress of crystallization in different units. Kaolinite is the main, often the only clay mineral in Mesozoic units. Heavy minerals, whose species spectra reflect on parent rock and provenance terrain and whose differential response to degradation points to the sedimentary history of the deposit, show certain vertical regularities, such as the abrupt disappearance of species or whole assemblages at certain levels, indicating unconformities. Trace metals, which in places reach ore concentrations (e.g. copper), are often extensive, though of well-defined vertical distribution. They express adsorptive capacity of specific widespread lithologies, enabling the discrimination of units. Even though each of these criteria is not always by itself diagnostic, they may in conjuction with one or more other criteria amount to a petrographic fingerprint that enables fairly accurate identification of the age interval of the unit, and its relation both to the regional and the local stratigraphic sequence.

Weissbrod, T.; Perath, I.

187

Herdabilidade e correlações quanto a peso, perímetro escrotal e escores visuais à desmama, em bovinos Canchim / Heritability and correlations for weight, scrotal circumference and visual scores at weaning, in Canchim beef cattle  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O objetivo deste trabalho foi estabelecer o modelo mais adequado para avaliação genética de bovinos Canchim e estimar os parâmetros genéticos de características produtivas à desmama. Foram utilizados dados de: 12.103 animais, quanto ao peso (PD); 5.278, quanto ao perímetro escrotal (PE); 8.343, quan [...] to ao escore visual da conformação frigorífica (CF); 9.111, quanto ao escore de umbigo (UM); e 7.986, quanto ao escore de pelame (PEL). Os modelos estatísticos incluíram os efeitos fixos e os efeitos aleatórios genéticos aditivos direto, materno e de ambiente permanente materno, em diferentes combinações. As análises foram feitas pelo método da máxima verossimilhança restrita livre de derivadas. O modelo completo foi o mais adequado para PD, PE, CF e UM, enquanto o modelo com uso apenas dos efeitos genéticos aditivos direto e materno foi o mais adequado para PEL. As estimativas de herdabilidade direta foram 0,17, 0,13, 0,20, 0,18, e 0,52 para PD, PE, CF, UM e PEL, respectivamente, o que indica a possibilidade de se obter progresso genético por meio da seleção para essas características, principalmente para PEL. As correlações genéticas aditivas diretas entre as características variaram de -0,16 a 0,61. As correlações entre PD e PE e entre PD e CF indicam que a seleção para PD deve proporcionar ganho genético em PE e CF Abstract in english The objective of this study was to establish the best-fit model for the genetic evaluation of Canchim cattle and to estimate the genetic parameters for productive characters at weaning. The data used were related to: 12,103 animals, for weight (PD); 5,278, for scrotal circumference (PE), 8,343, for [...] slaughter conformation visual score (CF); 9,111, for sheath and navel scores (UM), and 7,986, for hair coat score (PEL). Statistical models included fixed effects and random additive direct, maternal and maternal permanent environmental effects, in different combinations. The analyses were done by the derivative-free restricted maximum likelihood method. The complete model was the most suited for PD, PE, CF and UM, while the model with only additive direct and additive maternal random effects was the best for PEL. Direct heritability estimates were 0.17, 0.13, 0.20, 0.18, and 0.52 for PD, PE, CF, UM and PEL, respectively, which indicates that it is possible to obtain genetic progress through selection for these traits, mainly for PEL. The additive direct genetic correlations among traits varied from -0.16 to 0.61. The correlations between PD and PE and between PD and CF indicate that selection for PD should result in genetic gain in PE and CF

Fabiana, Barichello; Maurício Mello de, Alencar; Roberto Augusto de Almeida, Torres Júnior; Luiz Otávio Campos da, Silva.

2010-06-01

188

SCORING SYSTEMS IN PEMPHIGUS  

OpenAIRE

Pemphigus is a dreaded disease encountered not infrequently in dermatology settings. While scoring systems in various dermatological conditions exist, objective parameters for assessing disease activity and therapeutic responses in pemphigus are not uniform and foolproof. This article presents various scoring systems in pemphigus.

Grover, Sanjiv

2011-01-01

189

Correlation between the concentration of serum polychlorinated biphenyls (PCBs) in pregnant cynomolgus monkeys and their offspring's behavioral scores in eye-contact test and finger maze learning test  

Energy Technology Data Exchange (ETDEWEB)

A recent review suggested that pre- or perinatal exposure of developing fetuses to dioxins, the widespread environmental contaminants, such as polychrorinated biphenlys (PCBs), induce the irreversible abnormalities in the functions of central nervous system (CNS) in human. These chemicals can be transferred to each fetus and naonate transplacentally and lactationally in rhesus monkey. Several studies also reported the adverse effect of PCB on CNS development in rodents and monkeys as well as on behavior in rodents and monkeys. In the present study, we show a preliminary data about the correlation between the serum concentrations of PCBs in pregnant cynomolgus monkeys (Macaca fascicularis) and the scores of two behavioral tests, eye-contact test and four-step finger maze test, which evaluate consciousness against human observer and learning ability, respectively, in their offspring. This experimental surveillance system using non-human primates would be useful to predict the risk of PCBs exposure in human fetuses because of the similarities of cynomolgus monkey to human with regard to reproduction, developmental parameter, and others.

Negishi, T. [Aoyama Gakuin Univ., Kanagawa (Japan); Takasuga, T. [Shimadzu Techno-Research Inc., Kyoto (Japan); Kawasaki, K. [Hoshi Univ., Tokyo (Japan); Kuroda, Y. [CREST Japan Science and Technology Corp., Saitama (Japan); Yoshikawa, Y. [The Univ. of Tokyo (Japan)

2004-09-15

190

7 CFR 1703.126 - Criteria for scoring grant applications.  

Science.gov (United States)

...within the project service area are identified and given...the population of the area where the end user sites... (i) The following definitions are used in the evaluation... (A) Exceptionally Rural Area means any area of...

2010-01-01

191

Overall functioning and criteria of progress in rehabilitation of alcohol abusers: longitudinal analyses of changes.  

Science.gov (United States)

The aim was to compare alcohol consumption and vocational adjustment as criteria of rehabilitation progress of alcoholics, with regard to links to concomitant changes in functioning in other life areas. Thirty-four advanced alcohol abusers in rehabilitation were examined twice with an interval of 2 years between each examination. Change scores in alcohol consumption and work capacity were correlated with change scores in social network, activities, life-satisfaction, psychological well-being, psychiatric symptoms, and biomedical functioning. Improved drinking habits were connected with some changes in overall functioning, however not solely in a favorable direction. Negative mood changes were especially noteworthy. Improvements in vocational adjustment, on the other hand, appeared to be somewhat more unequivocally and encompassingly associated with amelioration in the wider range of functioning. The results indicate that drinking measures alone are not sufficient indicators of progress in rehabilitation and underscores the need of more global criteria of general adjustment. PMID:2088121

Akerlind, I; Hörnquist, J O; Elton, M; Bjurulf, P

1990-12-01

192

Comparison of Prognosis in Patients with Liver Cirrhosis and its Correlation with the Model for the End-Stage Liver Disease and Child-PughChild-Pugh Scores in Patients with Esophageal or Gastric Variceal Bleeding  

OpenAIRE

Background:Variceal bleeding is one of the most serious complications of cirrhosis. Up to now different methods are created for predicting the complications and mortality of cirrhosis. Child- Pugh score and MELD score are two methods for this use. In this study we investigated and compared survival prognosis of cirrhotic patients by the Child-Pugh or MELD score in two groups of esophageal and gastric variceal bleeding. Materials and Methods: In this cross-sectional trial, patients with upper ...

Mohammadreza Sheikhian; Mohsen Ebrahimi; Seyedeh Masoumeh Pashai

2013-01-01

193

Malnutrition-Inflammation Score in Hemodialysis Patients  

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Full Text Available Background: Malnutrition is a prevalent complication in patients on maintenance hemodialysis. Malnutrition-inflammation score (MIS, comprehensive nutritional assessment tool, as the reference standard was used to examine protein-energy wasting (PEW and inflammation in hemodialysis patients. Materials and Methods: In this descriptive- analytical study, 48 hemodialysis patients were selected with random sampling. All the patients were interviewed and the MIS of the patients was recorded. This new comprehensive Malnutrition-Inflammation Score (MIS which involves 7 components from the SGA and the 3 additional non-SGA components of body mass index, serum albumin, and total iron-binding capacity (TIBC has 10 components, each with four levels of severity, from 0 (normal to 3 (very severe. These scores were compared with anthropometric measurements; laboratory measures. Data was analyzed with Chi-square and t-tests and Pearson correlation coefficiant. Results: In this study 25% of patients on hemodialysis were normal nourished, 54.3% of patients were mild malnourished, 20.8% were moderately malnourished and no one of them were not sever malnurished. Pearson correlation coefficients between MIS score and age (r=+0.332 was significant. There was no correlation between the malnutrition score and sex Chi-square test showed significant correlation between MIS score and dialysis period ?50 months (?²=9.09. Conclusion: In this study, no one of patients has severed malnutrition, and most of them were assigned to the mildly/moderately malnourished rating. On other hand, most of patients are the well-nourished. Correlation between MIS score and age and dialysis period was significant.

Behrooz Ebrahimzadehkor

2014-08-01

194

Genetic parameters for androstenone, skatole, indole, and human nose scores as measures of boar taint and their relationship with finishing traits  

OpenAIRE

The purpose of this study was to evaluate measures of boar (Sus scrofa) taint as potential selection criteria to reduce boar taint so that castration of piglets will become unnecessary. Therefore, genetic parameters of boar taint measures and their genetic correlations with finishing traits were estimated. In particular, the usefulness of a human panel assessing boar taint (human nose score) was compared with chemical assessment of boar taint compounds, androstenone, skatole, and indole. Heri...

Windig, J. J.; Mulder, H. A.; Napel, J.; Knol, E. F.; Mathur, P. K.; Crump, R. E.

2012-01-01

195

Volleyball Scoring Systems.  

Science.gov (United States)

The widespread interest in sports in our culture provides an excellent opportunity to catch students' attention in mathematics and statistics classes. One mathematically interesting aspect of volleyball, which can be used to motivate students, is the scoring system. (MM)

Calhoun, William; Dargahi-Noubary, G. R.; Shi, Yixun

2002-01-01

196

College Math Assessment: SAT Scores vs. College Math Placement Scores  

Science.gov (United States)

Many colleges and university's use SAT math scores or math placement tests to place students in the appropriate math course. This study compares the use of math placement scores and SAT scores for 188 freshman students. The student's grades and faculty observations were analyzed to determine if the SAT scores and/or college math assessment scores

Foley-Peres, Kathleen; Poirier, Dawn

2008-01-01

197

A new electrocardiographic left ventricular hypertrophy prognostic score.  

Science.gov (United States)

This report determines if the classic Romhilt-Estes score would predict better if points for its components were determined using a Cox hazard model and if the Cornell voltage criteria should replace the original criteria. Of the 20,903 subjects, the mean age was 43 ± 10 years and 90.6% were men. The mean follow-up for the population was 17 years, with 881 cardiovascular deaths; they were tested from 1987 to 1999 and followed until 2013. The new score was created with multipliers based on the Cox hazards of its elements with age bracket and gender included. The Cornell criteria were analyzed individually using Cox hazards with and without adjustments for age, gender, and African-American ethnicity and subsequently incorporated into the new score for analysis. For the new score, all 7 components were significant predictors of cardiovascular mortality with gender producing the greatest hazard ratio (HR) and left axis deviation and QRS duration >110 ms producing the lowest. For the original Romhilt-Estes score, 367 patients (1.8%) met the "definite" cutoff and had an HR of 5.6 (95% confidence interval 4.3 to 7.1). For the new score, 208 patients (1.0%) met the "definite" left ventricular hypertrophy cutoff and had an HR of 13.6 (95% confidence interval 10.8 to 17.3). The Romhilt-Estes had an area under the curve of 0.63, whereas the new score and new score with Cornell voltage both had an area under the curve of 0.7. In conclusion, our modified Romhilt-Estes score with new multipliers and without voltage criteria outperformed the original score. PMID:25700803

Jindal, Akash; Singla, Varun; Pargaonkar, Vedant; Froelicher, Victor

2015-04-01

198

A visual system for scoring body condition of Asian elephants (Elephas maximus).  

Science.gov (United States)

A body condition score (BCS) may provide information on the health or production potential of an animal; it may also reflect the suitability of the environment to maintain an animal population. Thus assessing the BCS of Asian elephants is important for their management. There is a need for a robust BCS applicable to both wild and captive elephants of all age categories based on the minimum and maximum possible subcutaneous body fat and muscle deposits. The visually based system for scoring the body condition of elephants presented here satisfies these criteria and is quick, inexpensive, non-invasive and user-friendly in the field. The BCS scale correlates (P?

Wijeyamohan, Shanmugasundaram; Treiber, Kibby; Schmitt, Dennis; Santiapillai, Charles

2015-01-01

199

Using Regression to Establish Weights for a Set of Composite Equations through a Numerical Analysis Approach: A Case of Admission Criteria to a College  

Directory of Open Access Journals (Sweden)

Full Text Available Problem statement: Mathematically little is known of college admission criteria as in school grade point average, admission test scores or rank in class and weighting of the criteria into a composite equation. Approach: This study presented a method to obtain weights on ?composite admission? equation. The method uses an iterative procedure to build a prediction equation for an optimal weighted admission composite score. The three-predictor variables, high school average, entrance exam scores and rank in class, were regressed on college Grade Point Average (GPA. The weights for the composite equation were determined through regression coefficients and numerical approach that correlate the composite score with college GPA. Results: A set of composite equations were determined with the weights on each criteria in a composite equation. Conclusion: This study detailed a substantiated algorithm and based on an optimal composite score, comes out with an original and unique structured composite score equation for admissions, which can be used by admission officers at colleges and universities.

Ramzi N. Nasser

2010-01-01

200

Introduction of a new standardized assessment score of spine morphology in osteogenesis imperfecta  

International Nuclear Information System (INIS)

Purpose: Osteogenesis imperfecta (OI) is a rare hereditary disease leading to multiple bone deformities and fractures. In the absence of causal therapy, a symptomatic approach is based on treatment with bisphosphonates and physiotherapy. The clinical and radiological manifestations vary. Therefore, standardization and quantification for an objective comparison, especially during therapy, are required. In this paper, radiological changes of the spine are quantified according to their clinical relevance to define a scoring system that transfers the morphological changes into a single value representing the severity of the disease. Materials and Methods: 268 lateral spine X-rays of 95 patients with OI (median age 5.6 years) were assessed. The findings were classified based on their clinical relevance. Results: The three criteria, vertebral compression, thoracolumbar kyphosis and deformity type, were quantified in a new grading system. Based on this, a 'severity classification' (1 to 5) was defined with implications for diagnostics and treatment. A mathematical formula that takes into account the three criteria and their correlations to clinical relevance, resulting in a 'severity score', was developed. Conclusion: 'Severity classification' and 'severity score' introduce a new concept for a standardized evaluation of spine X-rays in patients with OI. For both scientific and routine purposes, it provides the user with a simple and easy-to-handle tool for assessing and compeasy-to-handle tool for assessing and comparing different stages of severity prior to and during therapy with detailed accuracy. (orig.)

201

Introduction of a new standardized assessment score of spine morphology in osteogenesis imperfecta  

Energy Technology Data Exchange (ETDEWEB)

Purpose: Osteogenesis imperfecta (OI) is a rare hereditary disease leading to multiple bone deformities and fractures. In the absence of causal therapy, a symptomatic approach is based on treatment with bisphosphonates and physiotherapy. The clinical and radiological manifestations vary. Therefore, standardization and quantification for an objective comparison, especially during therapy, are required. In this paper, radiological changes of the spine are quantified according to their clinical relevance to define a scoring system that transfers the morphological changes into a single value representing the severity of the disease. Materials and Methods: 268 lateral spine X-rays of 95 patients with OI (median age 5.6 years) were assessed. The findings were classified based on their clinical relevance. Results: The three criteria, vertebral compression, thoracolumbar kyphosis and deformity type, were quantified in a new grading system. Based on this, a 'severity classification' (1 to 5) was defined with implications for diagnostics and treatment. A mathematical formula that takes into account the three criteria and their correlations to clinical relevance, resulting in a 'severity score', was developed. Conclusion: 'Severity classification' and 'severity score' introduce a new concept for a standardized evaluation of spine X-rays in patients with OI. For both scientific and routine purposes, it provides the user with a simple and easy-to-handle tool for assessing and comparing different stages of severity prior to and during therapy with detailed accuracy. (orig.)

Koerber, F.; Schulze Uphoff, U.; Koerber, S.; Maintz, D. [Koeln Univ. (Germany). Dept. of Radiology; Schoenau, E.; Semler, O. [Koeln Univ. (Germany). Children' s Hospital

2012-08-15

202

Comparison of Prognosis in Patients with Liver Cirrhosis and its Correlation with the Model for the End-Stage Liver Disease and Child-PughChild-Pugh Scores in Patients with Esophageal or Gastric Variceal Bleeding  

Directory of Open Access Journals (Sweden)

Full Text Available Background:Variceal bleeding is one of the most serious complications of cirrhosis. Up to now different methods are created for predicting the complications and mortality of cirrhosis. Child- Pugh score and MELD score are two methods for this use. In this study we investigated and compared survival prognosis of cirrhotic patients by the Child-Pugh or MELD score in two groups of esophageal and gastric variceal bleeding. Materials and Methods: In this cross-sectional trial, patients with upper GI bleeding were followed up for a 6 months period. The source of hemorrhage was determined by endoscopy, then patients distributed in two groups of esophageal and gastric variceal hemorrhage. Finally we investigated and compared the relationship between the variables and mortality rates in these two groups by means of the Child-Pugh and the MELD scores. The Student’s t-test and Receiver Operating Characteristic were used for statistical analysis.Results: 34 patients (12 with gastric varices, 22 with esophageal varices were investigated. No significant difference between these two groups was observed. In this study mean MELD score was 16.67±8.75 and mean Child-Pugh score was 9.37±2.54. Eight patients (5 with gastric varices and 3 with esophageal varices expired before 6 weeks and 2 patients (one four each group expired after 6 weeks. The best cut-off points are 15.5 and 10.5 for MELD and Child-Pugh scores respectively (sensitivity and specificity are 0.75 and 0.98, respectively for both scores.Conclusion:Sensitivity and specificity of both scores were the same in prediction of mortality. However, the chance ratio defined that Child-Pugh score was a better predictor of mortality than MELD score, since the chance of death will increase 2.51 and 1.62 fold per each unit increase in the Child-Pugh and the MELD scores, respectively. However, no significant difference found between Child-Pugh and MELD score between two groups of patients.

Mohammadreza Sheikhian

2013-09-01

203

Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics  

OpenAIRE

There is critical need for improved biomarker assessment platforms which integrate traditional pathological parameters (TNM stage, grade and ER/PR/HER2 status) with molecular profiling, to better define prognostic subgroups or systemic treatment response. One roadblock is the lack of semi-quantitative methods which reliably measure biomarker expression. Our study assesses reliability of automated immunohistochemistry (IHC) scoring compared to manual scoring of five selected biomarkers in a ti...

Yolanda Madarnas; Sengupta, Sandip K.; Elliott, Bruce E.; Jeremy Squire; Raptis, Leda H.; Rajput, Ashish B.; Day, Andrew G.; Waheed Sangrar; Sonal Varma; Cass, Jamaica D.

2012-01-01

204

Instant MuseScore  

CERN Document Server

Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. Instant MuseScore is written in an easy-to follow format, packed with illustrations that will help you get started with this music composition software.This book is for musicians who would like to learn how to notate music digitally with MuseScore. Readers should already have some knowledge about musical terminology; however, no prior experience with music notation software is necessary.

Shinn, Maxwell

2013-01-01

205

Description and validation of a scoring system for tomosynthesis in pulmonary cystic fibrosis  

Energy Technology Data Exchange (ETDEWEB)

To design and validate a scoring system for tomosynthesis (digital tomography) in pulmonary cystic fibrosis. A scoring system dedicated to tomosynthesis in pulmonary cystic fibrosis was designed. Three radiologists independently scored 88 pairs of radiographs and tomosynthesis examinations of the chest in 60 patients with cystic fibrosis and 7 oncology patients. Radiographs were scored according to the Brasfield scoring system and tomosynthesis examinations were scored using the new scoring system. Observer agreements for the tomosynthesis score were almost perfect for the total score with square-weighted kappa >0.90, and generally substantial to almost perfect for subscores. Correlation between the tomosynthesis score and the Brasfield score was good for the three observers (Kendall's rank correlation tau 0.68, 0.77 and 0.78). Tomosynthesis was generally scored higher as a percentage of the maximum score. Observer agreements for the total score for Brasfield score were almost perfect (square-weighted kappa 0.80, 0.81 and 0.85). The tomosynthesis scoring system seems robust and correlates well with the Brasfield score. Compared with radiography, tomosynthesis is more sensitive to cystic fibrosis changes, especially bronchiectasis and mucus plugging, and the new tomosynthesis scoring system offers the possibility of more detailed and accurate scoring of disease severity. (orig.)

Vult von Steyern, Kristina; Bjoerkman-Burtscher, Isabella M.; Bozovic, Gracijela; Wiklund, Marie; Geijer, Mats [Skaane University Hospital, Lund University, Centre for Medical Imaging and Physiology, Lund (Sweden); Hoeglund, Peter [Skaane University Hospital, Competence Centre for Clinical Research, Lund (Sweden)

2012-12-15

206

La evaluación de revistas de psicología: correlación entre el factor de impacto, el índice h y los criterios de Latindex / Assessment of psychology journals: correlation of impact factor and h-index vs. Latindex criteria  

Scientific Electronic Library Online (English)

Full Text Available El objetivo de este trabajo fue comprobar el grado en que dos criterios basados en el recuento de citas, como el factor de impacto propuesto por el Journal Citation Reports y el índice h de Hirsch (2005), y otro criterio más relacionado con la calidad del proceso editorial, como el grado de cumplimi [...] ento de los criterios propuestos por el catálogo Latindex, ordenan de forma similar un conjunto de revistas de psicología. Utilizamos estos tres criterios para confeccionar sendas clasificaciones de estas revistas y encontramos que la correlación entre la clasificación Latindex y cualquiera de las otras dos no fue significativamente distinta de cero. Se discute la conveniencia de disponer de criterios ajenos al recuento de citas para evaluar la calidad de las revistas científicas de psicología y se propone el uso combinado de criterios como la difusión, la internacionalidad, el proceso de revisón de los manuscritos o la política editorial de la revista. Abstract in english The goal of this study is to explore the extent to which several psychology journals may be similarly classified on the basis of citation count through the impact factor proposed by Journal Citation Reports and the hindex (Hirsch, 2005), against a given journal's compliance with the Latindex Catalog [...] ue criteria for assessing editorial quality. Using these parameters, we carried out three separate journal rankings and found that the correlation between the Latindex ranking and either of the former is not statistically distinct from zero. The suitability of applying editorial- rather than citation-based criteria to evaluate the quality of psychology journals is discussed. This discussion proposes using a mix of editorial criteria such as circulation, international reach and the journal's manuscript review process and editorial policies.

A. Matías, Gámez.

2013-12-01

207

A Clinical Scoring System for Selection of Patients for PTEN Mutation Testing Is Proposed on the Basis of a Prospective Study of 3042 Probands  

Science.gov (United States)

Cowden syndrome (CS) and Bannayan-Riley-Ruvalcaba syndrome are allelic, defined by germline PTEN mutations, and collectively referred to as PTEN hamartoma tumor syndrome. To date, there are no existing criteria based on large prospective patient cohorts to select patients for PTEN mutation testing. To address these issues, we conducted a multicenter prospective study in which 3042 probands satisfying relaxed CS clinical criteria were accrued. PTEN mutation scanning, including promoter and large deletion analysis, was performed for all subjects. Pathogenic mutations were identified in 290 individuals (9.5%). To evaluate clinical phenotype and PTEN genotype against protein expression, we performed immunoblotting (PTEN, P-AKT1, P-MAPK1/2) for a patient subset (n = 423). In order to obtain an individualized estimation of pretest probability of germline PTEN mutation, we developed an optimized clinical practice model to identify adult and pediatric patients. For adults, a semiquantitative score—the Cleveland Clinic (CC) score—resulted in a well-calibrated estimation of pretest probability of PTEN status. Overall, decreased PTEN protein expression correlated with PTEN mutation status; decreasing PTEN protein expression correlated with increasing CC score (p < 0.001), but not with the National Comprehensive Cancer Network (NCCN) criteria (p = 0.11). For pediatric patients, we identified highly sensitive criteria to guide PTEN mutation testing, with phenotypic features distinct from the adult setting. Our model improved sensitivity and positive predictive value for germline PTEN mutation relative to the NCCN 2010 criteria in both cohorts. We present the first evidence-based clinical practice model to select patients for genetics referral and PTEN mutation testing, further supported biologically by protein correlation. PMID:21194675

Tan, Min-Han; Mester, Jessica; Peterson, Charissa; Yang, Yiran; Chen, Jin-Lian; Rybicki, Lisa A.; Milas, Kresimira; Pederson, Holly; Remzi, Berna; Orloff, Mohammed S.; Eng, Charis

2011-01-01

208

Cash for Test Scores  

Science.gov (United States)

Cash incentives for high school students to perform better in school are growing in popularity, but not everyone understands them. Does paying students for better Advanced Placement (AP) test scores encourage enrollment in AP classes? The author set out to determine the impact of a cash incentive program operating in a number of Texas high…

Jackson, C. Kirabo

2008-01-01

209

Satisfaction in hospitality on TripAdvisor.com: An analysis of the correlation between evaluation criteria and overall satisfaction / A satisfação na hotelaria pelo TripAdvisor: uma análise da correlação entre os critérios de avaliação e satisfação geral  

Scientific Electronic Library Online (English)

Full Text Available As mídias sociais alteraram a forma dos turistas buscarem e trocarem informações, determinando mudanças gerenciais para as empresas turísticas, incluindo os meios de hospedagem. Os comentários e avaliações de hóspedes têm impactado na reputação das organizações, tanto positivamente como negativament [...] e. Os sítios de conteúdo gerado pelos usuários permitem que estas informações cheguem a outros turistas, através da avaliação do serviço prestado e influenciando na decisão de novos visitantes. Desta forma, esta investigação procurou identificar a correlação entre a satisfação geral e os critérios de avaliação. Para isto, foram analisadas 660 avaliações (236 nos hotéis 03 estrelas, 125 nos hotéis 04 estrelas e 299 nos hotéis 05 estrelas) no Tripadvisor, que continham de forma independente, avaliações sobre: satisfação geral, valor (custo-benefício), localização, qualidade do sono, quartos, limpeza e serviço. Os resultados apontaram para um maior índice de correlação da satisfação geral com os critérios quarto, serviço ofertado e custo-benefício. Abstract in english Social media has changed the way tourists seek and exchange information, resulting in changes in the management of tourism businesses including hospitality facilities. Guest reviews and comments have had an impact on the reputation of organisations, both positive and negative. Websites with user-gen [...] erated content spread this information to other tourists through the evaluation of service provided and thereby influence the decision of new visitors. Accordingly, this research sought to identify the correlation between overall satisfaction and the evaluation criteria used on a website. For this, we analysed 660 reviews (236 of three-star hotels, 125 of four-star hotels and 299 of five-star hotels) on TripAdvisor, containing independent reviews including overall satisfaction, value (cost-benefit), location, sleep quality, rooms, cleanliness and service. Results showed a strong correlation of overall satisfaction with the criteria of room, service provided and cost-benefit.

Pablo Flôres, Limberger; Francisco Antonio dos, Anjos; Jéssica Vieira de Souza, Meira; Sara Joana Gadotti dos, Anjos.

2014-01-01

210

Fetal Biophysical Profile Scoring  

Directory of Open Access Journals (Sweden)

Full Text Available   "nFetal biophysical profile scoring is a sonographic-based method of fetal assessment first described by Manning and Platt in 1980. "nThe biophysical profile score was developed as a method to integrate real-time observations of the fetus and his/her intrauterine environment in order to more comprehensively assess the fetal condition. These findings must be evaluated in the context of maternal/fetal history (i.e., chronic hypertension, post-dates, intrauterine growth restriction, etc, fetal structural integrity (presence or absence of congenital anomalies, and the functionality of fetal support structures (placental and umbilical cord. For example, acute asphyxia due to placental abruption may result in an absence of the acute variables of the biophysical profile score (fetal breathing movements, fetal movement, fetal tone, and fetal heart rate reactivity with a normal amniotic fluid volume. With post maturity the asphyxial event may be intermittent and chronic resulting in a decrease in amniotic fluid volume, but with the acute variables remaining normal. "nWhile the 5 components of the biophysical profile score have remained unchanged since 1980 (Manning, 1980, the definitions of a normal and abnormal parameter have evolved with increasing experience. "nIn 1984 the definition of oligohydramnios was increased from < 1cm pocket of fluid to < 2.0 x 1.0 cm pocket. Oligohydramnios is now defined as a pocket of amniotic fluid < 2.0 x 2.0 cm (Manning, 1995a "nIf the four ultrasound variables are normal, the accuracy of the biophysical profile score was not found to be significantly improved by adding the non-stress test. As a result, in 1987 the profile score was modified to incorporate the non-stress test only when one of the ultrasound variables was abnormal (Manning 1987. Table 1 outlines the current definitions for quantifying a variable as present or absent. "nEach of the 5 components of the biophysical profile score does not have equal significance. Fetal breathing movements, amniotic fluid volume, and the non-stress test are the most powerful variables. For example, when the biophysical profile score is 2, the perinatal mortality varies between 428/1000 with only fetal movement present to 66/1000 if the non-stress test is reactive and all of the ultrasound parameters are absent (Manning 1990b. Some authors have, therefore, proposed utilization of a modified biophysical profile that incorporates only the non-stress test and amniotic fluid volume (Miller 1996. Although the positive predictive value of these 2 tests is equivalent to a biophysical profile score of 6, the perinatal mortality is still increased over a normal test score of 8 or 10 (Manning 1990b. The false positive rate with the modified biophysical profile score is also substantially higher. "nConclusions: The fetus expresses its well being or compromised status through a number of different biophysical activities that are controlled by different central nervous system centers. The utilization of the biophysical score for antepartum surveillance in high-risk patients has resulted in a reduction in perinatal mortality when compared to historical controls. The appropriate management of the viable fetus with an abnormal biophysical profile score may also decrease long-term neurological morbidity (Manning 1998. "nIt is unlikely that in the future additional variables will be added to the biophysical profile score. However, perhaps the incorporation of the fetal state (i.e., eye movements and Doppler flow studies of specific fetal vessels (umbilical artery, middle cerebral artery, ductus venosus will be incorporated into a complete assessment of the fetal condition "n "nTable 1. Components of the 30 Minute Biophysical Profile Score "nComponent "nDefinition "nFetal movements "n> 3 body or limb movements "nFetal tone "nOne episode of active extension and flexion of the limbs; opening and closing of hand "nFetal breathing movements "n>1

H.R. HaghighatKhah

2009-01-01

211

Beyond the Score: Clinical Evaluation Through Formal Psychological Assessment.  

Science.gov (United States)

Questionnaires generate numerical scores, but endorsing different sets of items could produce the same score despite reflecting qualitatively different configurations of clinical features. Formal psychological assessment (FPA) attempts to overcome this by identifying the clinical features entailed by observed response patterns. This study illustrates an application of FPA to the cleaning subscale of a questionnaire assessing obsessive-compulsive symptoms and DSM-IV-TR diagnostic criteria for obsessive-compulsive disorder. A deterministic model of the items-criteria relationships was constructed by mapping each item to each diagnostic criterion. The resulting model was tested on a large community sample (N = 4,412). Results indicate that the theoretical model has adequate fit; item error rates and probabilities for each of the criteria are examined. Clinically relevant examples of the items-criteria relationships are discussed. Possible applications of FPA to personality assessment are also discussed, including long multidimensional questionnaires and questionnaires that use subtle item content. PMID:25257993

Bottesi, Gioia; Spoto, Andrea; Freeston, Mark H; Sanavio, Ezio; Vidotto, Giulio

2014-09-25

212

Association between eating behavior scores and obesity in Chilean children  

OpenAIRE

Abstract Background Inadequate eating behavior and physical inactivity contribute to the current epidemic of childhood obesity. The aim of this study was to assess the association between eating behavior scores and childhood obesity in Chilean children. Design and methods We recruited 126 obese, 44 overweight and 124 normal-weight Chilean children (6-12 years-old; both genders) according to the International Obesity Task Force (IOTF) criteria. Eating behavior scores were calculated using the ...

Amador Paola; Obregón Ana M; Cataldo Rodrigo; Domínguez-Vásquez Patricia; Smalley Susan V; González Andrea; Ho-Urriola Judith A; Santos José L; Weisstaub Gerardo; Isabel, Hodgson M.

2011-01-01

213

Analysis of PIK3CA exon 9 and 20 mutations in breast cancers using PCR-HRM and PCR-ARMS: correlation with clinicopathological criteria.  

Science.gov (United States)

Phosphatidylinositol-3-kinases (PI3K) are essential for cell signaling, proliferation, differentiation and survival. The catalytic subunit of PI3K, encoded by the PIK3CA oncogene, is mutated in 18-45% of breast carcinomas. These mutations, involved in tumorigenic processes, activate the PI3K/AKT/mTOR signaling pathway. Resistance to anti?human epidermal growth factor receptor, hormonal or anti-PI3K therapies have been described in breast carcinomas bearing activation of the PI3K signaling pathway. The present study reports the evaluation of PIK3CA exon 9 and 20 mutations in 149 invasive breast cancer cases using a validated PCR-high resolution melting assay (PCR-HRM). An amplification refractory mutation system (PCR-ARMS) using allele-specific scorpion primers was used to detect hotspot mutations in exons 9 (c.1624G?A and c.1633G?A) and 20 (c.3140A?G and c.3140A?T) in 118 tumor specimens. No correlation was observed with age at diagnosis, histological type, hormone receptor and HER2 status. PIK3CA exon 9 and 20 mutations were found to be related to Scarff-Bloom-Richardson (SBR) grade with a lower rate of mutations and a higher frequency of exon 9 mutations in SBRI and exon 20 mutations in SBRII/III tumors. No difference was observed in the incidence rates of the two different mutations screened for each exon in any subcategory. A statistically significant correlation was found between PCR-HRM and PCR-ARMS (?=0.845; P<0.001). PCR-ARMS was found to be more sensitive than PCR-HRM (sensitivity 0.5 and 5-10% of mutated DNA, respectively). We propose that PCR-HRM and PCR-ARMS can be combined for the cost-effective routine clinical identification of PIK3CA mutations for the purpose of personalizing therapy for invasive breast cancers. PMID:23314198

Harlé, Alexandre; Lion, Maëva; Lozano, Nicolas; Husson, Marie; Harter, Valentin; Genin, Pascal; Merlin, Jean-Louis

2013-03-01

214

Criteria for performance evaluation  

Directory of Open Access Journals (Sweden)

Full Text Available Using a cognitive task (mental calculation and a perceptual-motor task (stylized golf putting, we examined differential proficiency using the CWS index and several other quantitative measures of performance. The CWS index (Weiss and Shanteau, 2003 is a coherence criterion that looks only at internal properties of the data without incorporating an external standard. In Experiment 1, college students (n = 20 carried out 2- and 3-digit addition and multiplication problems under time pressure. In Experiment 2, experienced golfers (n = 12, also college students, putted toward a target from nine different locations. Within each experiment, we analyzed the same responses using different methods. For the arithmetic tasks, accuracy information (mean absolute deviation from the correct answer, MAD using a coherence criterion was available; for golf, accuracy information using a correspondence criterion (mean deviation from the target, also MAD was available. We ranked the performances of the participants according to each measure, then compared the orders using Spearman's rextsubscript{s}. For mental calculation, the CWS order correlated moderately (rextsubscript{s} =.46 with that of MAD. However, a different coherence criterion, degree of model fit, did not correlate with either CWS or accuracy. For putting, the ranking generated by CWS correlated .68 with that generated by MAD. Consensual answers were also available for both experiments, and the rankings they generated correlated highly with those of MAD. The coherence vs. correspondence distinction did not map well onto criteria for performance evaluation.

David J. Weiss

2009-03-01

215

Validating MMI scores: are we measuring multiple attributes?  

Science.gov (United States)

The multiple mini-interview (MMI) used in health professional schools' admission processes is reported to assess multiple non-cognitive constructs such as ethical reasoning, oral communication, or problem evaluation. Though validation studies have been performed with total MMI scores, there is a paucity of information regarding how well MMI scores differentiate the constructs being measured, the relationship between MMI scores (construct or total) and personality characteristics, and how well MMI scores (construct or total) predict future performance in practice. Results from these studies could assist with MMI station development, rater training, score interpretation, and resource allocation. The purpose of this study was to investigate the validity of MMI construct scores (oral communication and problem evaluation), and their relationship to personality measures (emotionality and extraversion) and specific scores from standardized clinical communications interviews (building the relationship and explaining and planning). Confirmatory factor analysis results support a two factor MMI model, however the correlation between these factors was .87. Oral communication MMI scores significantly correlated with extraversion (r c = .25, p < .05), but MMI scores were not related to emotionality. Scores for building a relationship were significantly related to MMI oral communication scores, (r c = .46, p < .001) and problem evaluation scores (r c = .43, p < .001); scores for explaining and planning were significantly related to MMI problem evaluation scores (r c = .36, p < .01). The results provide validity evidence for assessing multiple non-cognitive attributes during the MMI process and reinforce the importance of developing MMI stations and scoring rubrics for attributes identified as important for future success in school and practice. PMID:24449121

Oliver, Tom; Hecker, Kent; Hausdorf, Peter A; Conlon, Peter

2014-08-01

216

Credit scoring methods.  

Czech Academy of Sciences Publication Activity Database

Ro?. 56, 3-4 (2006), s. 152-167. ISSN 0015-1920 R&D Projects: GA ?R GA402/05/0931 Institutional research plan: CEZ:AV0Z70850503 Keywords : banking sector * credit scoring * discrimination analysis Subject RIV: AH - Economics Impact factor: 0.190, year: 2006 http://journal.fsv.cuni.cz/storage/1050_s_152_167.pdf

Vojtek, Martin; Ko?enda, Evžen

2006-01-01

217

Credit scoring for individuals  

Directory of Open Access Journals (Sweden)

Full Text Available Lending money to different borrowers is profitable, but risky. The profits come from the interest rate and the fees earned on the loans. Banks do not want to make loans to borrowers who cannot repay them. Even if the banks do not intend to make bad loans, over time, some of them can become bad. For instance, as a result of the recent financial crisis, the capability of many borrowers to repay their loans were affected, many of them being on default. That’s why is important for the bank to monitor the loans. The purpose of this paper is to focus on credit scoring main issues. As a consequence of this, we presented in this paper the scoring model of an important Romanian Bank. Based on this credit scoring model and taking into account the last lending requirements of the National Bank of Romania, we developed an assessment tool, in Excel, for retail loans which is presented in the case study.

Maria DIMITRIU

2010-12-01

218

Score test variable screening.  

Science.gov (United States)

Variable screening has emerged as a crucial first step in the analysis of high-throughput data, but existing procedures can be computationally cumbersome, difficult to justify theoretically, or inapplicable to certain types of analyses. Motivated by a high-dimensional censored quantile regression problem in multiple myeloma genomics, this article makes three contributions. First, we establish a score test-based screening framework, which is widely applicable, extremely computationally efficient, and relatively simple to justify. Secondly, we propose a resampling-based procedure for selecting the number of variables to retain after screening according to the principle of reproducibility. Finally, we propose a new iterative score test screening method which is closely related to sparse regression. In simulations we apply our methods to four different regression models and show that they can outperform existing procedures. We also apply score test screening to an analysis of gene expression data from multiple myeloma patients using a censored quantile regression model to identify high-risk genes. PMID:25124197

Zhao, Sihai Dave; Li, Yi

2014-12-01

219

Ki-67 expression score correlates to survival rate in gastrointestinal stromal tumors (GIST) / Escore de expressão de Ki-67 correlaciona-se com taxa de sobrevida em tumores estromais gastrointestinais (GIST)  

Scientific Electronic Library Online (English)

Full Text Available OBJETIVO: Avaliar a expressão imunoistoquímica de p16, Ki-67, p53 e Bcl-2 proteínas em tumores gastrointestinais estromais (GIST); determinar a possível associação entre essas variáveis e fatores clínicos e histopatológicos de câncer, e para verificar o valor prognóstico destas variáveis (sobrevivên [...] cia e recorrência). MÉTODOS: Uma amostra de 55 pacientes tratados cirurgicamente para GIST em três hospitais foi estudada. Os tumores extirpados cirurgicamente foram confirmados como GIST por KIT, vimentina, proteína desmina S100, CD117, 1A4 e avaliação de CD34 em blocos de parafina. RESULTADOS: Apenas nove (16%) casos de GIST foram positivos para p53, p16 foi positiva em 43,6%, 80% dos GIST apresentaram coloração para Bcl-2. O índice proliferativo (expresso como a proporção de células positivas), avaliado pela expressão imunoistoquímica de Ki-67, foi elevado em 49% dos casos. Escores de Ki-67 elevados foram associados com alto grau histológico (p=0,0026) e índice de mitose, MI (p=0,0001). Alto índice de Ki-67 foi associado à morte. Expressão da p53, p16 e Bcl-2 não se correlacionou com as variáveis morfológicas ou clínicas. CONCLUSÕES: A avaliação imunoistoquímica de Ki-67 deve ser incluída na avaliação pré-operatória de biópsias ou peças cirúrgicas de GIST como uma ferramenta prognóstica para o estadiamento clínico, e todas as outras proteínas estudadas (Bcl-2, p53 e p16) não desempenharam um papel no processo metabólico ou carcinogênico em GIST, mantendo-se sem valor prognóstico. Abstract in english PURPOSE: To evaluate the immunohistochemical expression of p16, Ki-67, p53 and Bcl-2 proteins in gastrointestinal stromal tumors (GIST); to assess the possible association between these variables and clinical and histopathological factors of cancer; and to check for prognostic value of these variabl [...] es (survival and recurrence). METHODS: A sample of 55 patients treated surgically for GIST in three hospitals was studied. The surgically excised tumors were confirmed as GIST by KIT, vimentin, desmin S100 protein, CD117, 1A4 and CD34 assessment in paraffin blocks. RESULTS: Only 9 (16%) cases of GIST were positive for p53, p16 was positive among 43.6%; 80% of GISTs showed staining for Bcl-2. The proliferative index (expressed as the proportion of positive cells) assessed by immunohistochemical expression of Ki-67 was high in 49% of cases. Elevated Ki-67 scores were associated to high histological grade (p=0.0026) and mitosis index, MI (p=0.0001). High Ki-67 index was associated to death. Expression of p53, p16 and Bcl-2 did not correlate to morphological or clinical variables. CONCLUSIONS: Ki-67 immunohistochemical evaluation should be included in preoperative evaluation of GIST biopsies or surgical specimens as a prognostic tool for clinical staging; and all other proteins studied (Bcl-2, p53 and p16) did not play a role in GIST metabolic or carcinogenic process, remaining without prognostic value.

Ricardo, Artigiani Neto; Angela Flavia, Logullo; João Norberto, Stávale; Laércio Gomes, Lourenço.

2012-05-01

220

An Analysis of Cross Racial Identity Scale Scores Using Classical Test Theory and Rasch Item Response Models  

Science.gov (United States)

Item response models (IRMs) were used to analyze Cross Racial Identity Scale (CRIS) scores. Rasch analysis scores were compared with classical test theory (CTT) scores. The partial credit model demonstrated a high goodness of fit and correlations between Rasch and CTT scores ranged from 0.91 to 0.99. CRIS scores are supported by both methods.…

Sussman, Joshua; Beaujean, A. Alexander; Worrell, Frank C.; Watson, Stevie

2013-01-01

221

Association between scores in high school, aptitude and achievement exams and early performance in health science college  

Directory of Open Access Journals (Sweden)

Full Text Available This retrospective study was carried out to assess the correlation between admi-ssion criteria to health science colleges, namely, final high school grade and Saudi National Apti-tude and Achievement exams, and early academic performance in these colleges. The study inclu-ded 91 male students studying in the two-year pre-professional program at the King Saud bin Abdulaziz University for Health Sciences (KSAU-HS, Riyadh, Saudi Arabia. Records of these students were used to extract relevant information and their academic performance (based on the grade point average achieved at the end of the first semester of the pre-professional program, which were analytically studied. Pearson correlation coefficient was used to assess the associa-tions between the different scores. SPSS statistical program (version 12.0 was used for data ana-lyses. We found a strong correlation between the academic performance and the Achievement Exam, Aptitude Exam and high school final grade, with Pearson Correlation Coefficients of 0.96, 0.93, 0.87, respectively. The Saudi National Achievement Exam showed the most significant correla-tion. Our results indicate that academic performance showed good correlation with the admission criteria used, namely final high school grade, Saudi National Aptitude and Achievement Exams.

Al-Alwan Ibrahim

2009-01-01

222

Prediction of School Readiness from Kindergarten Temperament Scores.  

Science.gov (United States)

Investigated relationship between temperament and school readiness scores among 152 kindergarten children. All correlations between Temperament Assessment Battery for Children (TABC) scales and Metropolitan Readiness Test (MRT) scores were significant when effects of receptive vocabulary were removed. Results showed that, once TABC persistence…

Schoen, Michael J.; Nagle, Richard J.

1994-01-01

223

Correlación entre las buenas prácticas de manufactura y el cumplimiento de los criterios microbiológicos en la fabricación de helados en Chile / Correlation between the good manufacturing practices and compliance with microbiological criteria in the manufacture of ice cream in Chile  

Scientific Electronic Library Online (English)

Full Text Available Las Buenas Prácticas de Manufacturas (BPM) son una herramienta básica para obtener un producto alimenticio seguro para consumo humano. El objetivo de este estudio fue determinar el porcentaje de cumplimiento de BPM y su correlación con la aceptación de criterios microbiológicos en fábricas y muestra [...] s de helados de Ñuble, Chile, de acuerdo al Reglamento Sanitario de Alimentos chilenos. Se analizaron auditorías de BPM aplicadas por fiscalizadores de Secretaría Regional Ministerial (SEREMI) de Salud Ñuble, a 40 fábricas de helados y los resultados microbiológicos de 435 muestras de helados entre los años 2005 y 2010. Se determinó que el 55,2% de las muestras no cumplieron para RAM (105 UFC/g) y coliformes (102 UFC/g) y 4,6% para Staphylococcus aureus (102 UFC/g), en cambio el 100% cumplieron para Salmonella spp. Los mayores RAM fueron en verano con 60% de rechazo. El 67% de auditorías de BPM alcanzaron valores superiores al mínimo (70% de cumplimiento), las instalaciones fue el ítem mejor evaluado (88,4%), y capacitación del personal el peor (20,3 %). La correlación entre los resultados de auditorías de BPM y criterios microbiológicos permitió comprobar que con un porcentaje igual o superior al 80% de cumplimiento de BPM se aseguraría la calidad microbiológica de helados, disminuyendo con ello el riesgo en la salud del consumidor. Abstract in english The Good Manufacturing Practices (GMP) is a basic tool to obtain safe foodstuffs for human consumption. The main goal of this research was to determine the percentage of compliance with GMP in ice cream factories and its correlation with the acceptance of microbiological criteria in samples of ice c [...] ream, according to the Sanitary Chilean Food Regulation. Inspectors from the Ministerial Regional Secretariat (SEREMI) of Health Ñuble audited GMP in 40 ice cream factories and 435 microbial analyses from ice cream samples taken between the years 2005 and 2010 were analyzed. Results showed that 55.2% of samples failed in RAM (105 UFC/g) and coliform (102 UFC/g) and 4.6% for Staphylococcus aureus (102 UFC/g) and 100% for Salmonella spp. The biggest RAM was during summer with 60% rejection. Sixty seven% of inspections of GMP reached values above the minimum (70% compliance). Facilities were the best item assessed (88.4%), and training was the worst (20.3%). The correlation between the results of audits of GMP and microbiological criteria allowed proving that with a percentage equal to or greater than 80% compliance with GMP would ensure the microbiological quality of ice cream, thereby decreasing the risk for consumer health.

José Miguel, Bastías M; Marcela, Cuadra H; Ociel, Muñoz F; Roberto, Quevedo L.

2013-06-01

224

What Is the Apgar Score?  

Science.gov (United States)

... condition and each factor is scored on a scale of 0 to 2, with 2 being the ... a baby's long-term health, behavior, intellectual status, personality, or outcome. Very few babies score a perfect ...

225

Prognostic criteria in acute pancreatitis: importance of assessment of pancreatic necrosis by contrast-enhanced CT  

International Nuclear Information System (INIS)

To compare the value of the clinical criteria of Ranson, the classical tomographic criteria of Balthzar and the severity of illness index according to CT in predicting the development of complications of acute pancreatitis. A retrospective study was performed in 100 patients with clinical and analytical evidence of acute pancreatitis. All patients were assessed according to Ranson score at admission and 48 hours later, and contrast-enhanced abdominal CT was carried out. The tomographic images were analyzed on the basis of the classical criteria of Balthazar and the new CT severity of illness index, which includes the assessment of pancreatic necrosis, identified as the areas of the pancreas that are not enhanced by the administration of the contrast material. These three criteria were then correlated with onset of medical and surgical implications. Our findings show that, of the three criteria analyzed, the CT severity of illness index presents the greatest specificity, sensitivity and positive and negative predictive values in the prediction of complications of acute pancreatitis. We conclude that the inclusion of pancreatic necrosis in the tomographic study improves the early assessment of the prognosis of acute pancreatitis. (Author) 20 refs

226

Fingerprinting of music scores  

Science.gov (United States)

Publishers of sheet music are generally reluctant in distributing their content via the Internet. Although online sheet music distribution's advantages are numerous the potential risk of Intellectual Property Rights (IPR) infringement, e.g. illegal online distributions, disables any innovation propensity. While active protection techniques only deter external risk factors, additional technology is necessary to adequately treat further risk factors. For several media types including music scores watermarking technology has been developed, which ebeds information in data by suitable data modifications. Furthermore, fingerprinting or perceptual hasing methods have been developed and are being applied especially for audio. These methods allow the identification of content without prior modifications. In this article we motivate the development of watermarking and fingerprinting technologies for sheet music. Outgoing from potential limitations of watermarking methods we explain why fingerprinting methods are important for sheet music and address potential applications. Finally we introduce a condept for fingerprinting of sheet music.

Irons, Jonathan; Schmucker, Martin

2004-06-01

227

An examination of the correlates of fearless dominance and self-centered impulsivity among high-frequency gamblers.  

Science.gov (United States)

The Psychopathic Personality Inventory (PPI) is a commonly used assessment of psychopathy. Questions have been raised, however, regarding the validity of its Fearless Dominance (FD) factor. In the current study, the correlations manifested by FD and Self-centered Impulsivity (ScI) in relation to external criteria were examined in a sample of gamblers. Two key hypotheses were also tested: (a) does FD perform differently when paired with high scores on ScI, and (b) does FD serve as an index of narcissism. As expected, FD and ScI manifested a divergent pattern of correlations such that only ScI was associated with psychopathology or impairment. FD's relations with the external criteria were not generally moderated by scores on ScI. FD was significantly correlated with narcissism, but the two differed such that only narcissism was associated with any degree of maladaptivity. It remains unclear whether FD should be considered a core component of psychopathy. PMID:24344842

Maples, Jessica L; Miller, Joshua D; Fortune, Erica; MacKillop, James; Campbell, W Keith; Lynam, Donald R; Lance, Chuck E; Goodie, Adam S

2014-06-01

228

Cardiovascular risk scores do not account for the effect of treatment: a review.  

OpenAIRE

OBJECTIVE: To compare the strengths and limitations of cardiovascular risk scores available for clinicians in assessing the global (absolute) risk of cardiovascular disease. DESIGN: Review of cardiovascular risk scores. DATA SOURCES: Medline (1966 to May 2009) using a mixture of MeSH terms and free text for the keywords 'cardiovascular', 'risk prediction' and 'cohort studies'. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: A study was eligible if it fulfilled the following criteria: (1) it was a...

Liew, Sm; Doust, J.; Glasziou, P.

2011-01-01

229

Setting safety criteria  

International Nuclear Information System (INIS)

The problem of excessive regulation in the USA is related. The author states that the most important underlying cause is that the regulators have either unreasonable criteria or poorly defined criteria for what is an acceptable level of risk. A discussion of safety criteria is presented. A few cases where safety criteria have been defined and have worked well as well as some examples of poorly defined and unworkable criteria are described. The case of plutonium and the possibility of developing acceptable safety criteria for its use is discussed

230

Association between value-based purchasing score and hospital characteristics  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Medicare hospital Value-based purchasing (VBP program that links Medicare payments to quality of care will become effective from 2013. It is unclear whether specific hospital characteristics are associated with a hospital’s VBP score, and consequently incentive payments. The objective of the study was to assess the association of hospital characteristics with (i the mean VBP score, and (ii specific percentiles of the VBP score distribution. The secondary objective was to quantify the associations of hospital characteristics with the VBP score components: clinical process of care (CPC score and patient satisfaction score. Methods Observational analysis that used data from three sources: Medicare Hospital Compare Database, American Hospital Association 2010 Annual Survey and Medicare Impact File. The final study sample included 2,491 U.S. acute care hospitals eligible for the VBP program. The association of hospital characteristics with the mean VBP score and specific VBP score percentiles were assessed by ordinary least square (OLS regression and quantile regression (QR, respectively. Results VBP score had substantial variations, with mean score of 30 and 60 in the first and fourth quartiles of the VBP score distribution. For-profit status (vs. non-profit, smaller bed size (vs. 100–199 beds, East South Central region (vs. New England region and the report of specific CPC measures (discharge instructions, timely provision of antibiotics and beta blockers, and serum glucose controls in cardiac surgery patients were positively associated with mean VBP scores (p Conclusions Although hospitals serving the poor and the elderly are more likely to score lower under the VBP program, the correlation appears small. Profit status, geographic regions, number and type of CPC measures reported explain the most variation among scores.

Borah Bijan J

2012-12-01

231

Scores on field independence and performance in snooker.  

Science.gov (United States)

The purpose of this study was to compare the scores on the Group Embedded Figures Test, a measure of field dependence, for 25 male intermediate-level snooker players with scores of 25 intermediate-level sportsmen engaged in soccer, rugby, field hockey, and tennis and to examine the relation between scores on field dependence and performance on a snooker decision-making test. All the snooker players also took a test of decision making in snooker. The snooker players scored significantly more field independent than the sports-science majors on the Group Embedded Figures Test. A Pearson correlation of 0.78 was obtained between scores on the Group Embedded Figures Test and the decision-making test. As there may be an association between scores on field dependence and decision making in snooker, further research should examine sports like lawn bowls and pool where decisions are made in a static environment. PMID:8170763

McMorris, T; Francis, M; MacDonald, A; Priday, K

1993-12-01

232

Performance of individual items of the quantitative myasthenia gravis score.  

Science.gov (United States)

We evaluated the quantitative myasthenia gravis score to determine which items better discriminate among patients and are most responsive to treatment. Current scoring ranges were compared to updated normative data when appropriate. Data from a previous study of intravenous immunoglobulin versus placebo in myasthenia gravis were analyzed. Each item of the quantitative myasthenia gravis score was analyzed for distribution, responsiveness and inter-item correlations. Items on swallowing, speaking and vital capacity had marked floor effects as did grip strength based on current normative data. The timed measures were responsive to treatment but diplopia, vital capacity and grip strength were not. Ocular items were not correlated with bulbar and generalized items (p>0.05), suggesting multi-dimensionality. Contralateral arm and leg tests were highly correlated (r>0.9, pMyasthenia Gravis Score, representing fatigability, are responsive to change and we propose new ranges based on updated normative data. PMID:23473730

Barnett, T Carolina; Bril, Vera; Davis, Aileen M

2013-05-01

233

Do medical students’ scores using different assessment instruments predict their scores in clinical reasoning using a computer-based simulation?  

Science.gov (United States)

Purpose The development of clinical problem-solving skills evolves over time and requires structured training and background knowledge. Computer-based case simulations (CCS) have been used for teaching and assessment of clinical reasoning skills. However, previous studies examining the psychometric properties of CCS as an assessment tool have been controversial. Furthermore, studies reporting the integration of CCS into problem-based medical curricula have been limited. Methods This study examined the psychometric properties of using CCS software (DxR Clinician) for assessment of medical students (n=130) studying in a problem-based, integrated multisystem module (Unit IX) during the academic year 2011–2012. Internal consistency reliability of CCS scores was calculated using Cronbach’s alpha statistics. The relationships between students’ scores in CCS components (clinical reasoning, diagnostic performance, and patient management) and their scores in other examination tools at the end of the unit including multiple-choice questions, short-answer questions, objective structured clinical examination (OSCE), and real patient encounters were analyzed using stepwise hierarchical linear regression. Results Internal consistency reliability of CCS scores was high (?=0.862). Inter-item correlations between students’ scores in different CCS components and their scores in CCS and other test items were statistically significant. Regression analysis indicated that OSCE scores predicted 32.7% and 35.1% of the variance in clinical reasoning and patient management scores, respectively (P<0.01). Multiple-choice question scores, however, predicted only 15.4% of the variance in diagnostic performance scores (P<0.01), while students’ scores in real patient encounters did not predict any of the CCS scores. Conclusion Students’ scores in OSCE are the most important predictors of their scores in clinical reasoning and patient management using CCS. However, real patient encounter assessment does not appear to test a construct similar to what is tested in CCS.

Fida, Mariam; Kassab, Salah Eldin

2015-01-01

234

Credit Scoring Modeling  

Directory of Open Access Journals (Sweden)

Full Text Available It is generally easier to predict defaults accurately if a large data set (including defaults is available for estimating the prediction model. This puts not only small banks, which tend to have smaller data sets, at disadvantage. It can also pose a problem for large banks that began to collect their own historical data only recently, or banks that recently introduced a new rating system. We used a Bayesian methodology that enables banks with small data sets to improve their default probability. Another advantage of the Bayesian method is that it provides a natural way for dealing with structural differences between a bank’s internal data and additional, external data. In practice, the true scoring function may differ across the data sets, the small internal data set may contain information that is missing in the larger external data set, or the variables in the two data sets are not exactly the same but related. Bayesian method can handle such kind of problem.

Siana Halim

2014-01-01

235

A scoring system for the assessment of angiographic findings in non-occlusive mesenteric ischemia (NOMI)  

International Nuclear Information System (INIS)

Purpose: To establish a standardized scoring system for angiographic findings in patients with non-occlusive mesenteric ischemia (NOMI). Materials and Methods: In 36 patients (mean age: 72 years), 53 angiographies of the superior mesenteric artery (SMA) were performed for suspected NOMI after cardiac or major aortic surgery. All examinations were performed using a standardized DSA technique. Two experienced radiologists performed a consensus reading blinded to the clinical information, on two occasions with an interval of two weeks. In order to investigate the reproducibility of the criteria, the images were assessed once by an intensivist and a medical student. Image analysis was performed with respect to vessel morphology, reflux of contrast medium into the aorta, small bowel parenchymal contrast enhancement and distension and the delay between arterial injection and portal vein filling. Results: Almost perfect intra-observer correlation was obtained for the assessment of the contrast medium reflux (? = 0.82) and substantial correlation for the time of portal vein filling (? = 0.66). Moderate correlations were obtained for the vessel morphology (? = 0.51), small bowel enhancement (? = 0.63) and distension (? = 0.53). Contrast medium reflux into the aorta (? = 0.77 and 0.63) and the time of portal vein filling (? = 0.42 and 0.58) resulted in the highest inter-observer correlations between the radiologists and the intensivist as well as the radiologists and theas well as the radiologists and the student. Conclusion: In patients with suspected NOMI, using our scoring system yields high intra- and inter-observer correlations, allowing a standardized evaluation of angiographic findings. (orig.)

236

A scoring system for the assessment of angiographic findings in non-occlusive mesenteric ischemia (NOMI)  

Energy Technology Data Exchange (ETDEWEB)

Purpose: To establish a standardized scoring system for angiographic findings in patients with non-occlusive mesenteric ischemia (NOMI). Materials and Methods: In 36 patients (mean age: 72 years), 53 angiographies of the superior mesenteric artery (SMA) were performed for suspected NOMI after cardiac or major aortic surgery. All examinations were performed using a standardized DSA technique. Two experienced radiologists performed a consensus reading blinded to the clinical information, on two occasions with an interval of two weeks. In order to investigate the reproducibility of the criteria, the images were assessed once by an intensivist and a medical student. Image analysis was performed with respect to vessel morphology, reflux of contrast medium into the aorta, small bowel parenchymal contrast enhancement and distension and the delay between arterial injection and portal vein filling. Results: Almost perfect intra-observer correlation was obtained for the assessment of the contrast medium reflux ({kappa} = 0.82) and substantial correlation for the time of portal vein filling ({kappa} = 0.66). Moderate correlations were obtained for the vessel morphology ({kappa} = 0.51), small bowel enhancement ({kappa} = 0.63) and distension ({kappa} = 0.53). Contrast medium reflux into the aorta ({kappa} = 0.77 and 0.63) and the time of portal vein filling ({kappa} = 0.42 and 0.58) resulted in the highest inter-observer correlations between the radiologists and the intensivist as well as the radiologists and the student. Conclusion: In patients with suspected NOMI, using our scoring system yields high intra- and inter-observer correlations, allowing a standardized evaluation of angiographic findings. (orig.)

Minko, P.; Stroeder, J.; Miodek, J.; Buecker, A.; Katoh, M. [Saarland Univ. Hospital, Homburg/Saar (Germany). Diagnostic and Interventional Radiology; Groesdonk, H.; Schaefers, H.J. [Saarland Univ. Hospital, Homburg/Saar (Germany). Dept. of Thoracic and Cardiovascular Surgery; Graeber, S. [Saarland Univ. Hospital, Homburg/Saar (Germany). Inst. of Medical Biometry, Epidemiology and Medical Informatics

2012-09-15

237

Evidence of Disseminated Intravascular Coagulation in a Hemorrhagic Fever with Renal Syndrome—Scoring Models and Severe Illness  

Science.gov (United States)

Background Viral hemorrhagic fevers (VHF) are considered to be a serious threat to public health worldwide with up to 100 million cases annually. The general hypothesis is that disseminated intravascular coagulation (DIC) is an important part of the pathogenesis. The study objectives were to study the variability of DIC in consecutive patients with acute hemorrhagic fever with renal syndrome (HFRS), and to evaluate if different established DIC-scores can be used as a prognostic marker for a more severe illness. Method and Findings In a prospective study 2006–2008, data from 106 patients with confirmed HFRS were analyzed and scored for the presence of DIC according to six different templates based on criteria from the International Society on Thrombosis and Haemostasis (ISTH). The DIC-scoring templates with a fibrinogen/CRP-ratio were most predictive, with predictions for moderate/severe illness (p<0.01) and bleeding of moderate/major importance (p<0.05). With these templates, 18.9–28.3% of the patients were diagnosed with DIC. Conclusions DIC was found in about one fourth of the patients and correlated with a more severe disease. This supports that DIC is an important part of the pathogenesis in HFRS. ISTH-scores including fibrinogen/CRP-ratio outperform models without. The high negative predictive value could be a valuable tool for the clinician. We also believe that our findings could be relevant for other VHFs. PMID:21731657

Sundberg, Erik; Hultdin, Johan; Nilsson, Sofie; Ahlm, Clas

2011-01-01

238

Comparing continuous and dichotomous scoring of the balanced inventory of desirable responding.  

Science.gov (United States)

The Balanced Inventory of Desirable Responding (BIDR; Paulhus, 1994) is a widely used instrument to measure the 2 components of social desirability: self-deceptive enhancement and impression management. With respect to scoring of the BIDR, Paulhus (1994) authorized 2 methods, namely continuous scoring (all answers on the continuous answer scale are counted) and dichotomous scoring (only extreme answers are counted). In this article, we report 3 studies with student samples, and continuous and dichotomous scoring of BIDR subscales are compared with respect to reliability, convergent validity, sensitivity to instructional variations, and correlations with personality. Across studies, the scores from continuous scoring (continuous scores) showed higher Cronbach's alphas than those from dichotomous scoring (dichotomous scores). Moreover, continuous scores showed higher convergent correlations with other measures of social desirability and more consistent effects with self-presentation instructions (fake-good vs. fake-bad instructions). Finally, continuous self-deceptive enhancement scores showed higher correlations with those traits of the Five-factor model for which substantial correlations were expected (i.e., Neuroticism, Extraversion, and Conscientiousness). Consequently, these findings indicate that continuous scoring may be preferable to dichotomous scoring when assessing socially desirable responding with the BIDR. PMID:12067199

Stöber, Joachim; Dette, Dorothea E; Musch, Jochen

2002-04-01

239

Evaluating the Internal Structure of the Eysenck Personality Questionnaire: Objective Criteria.  

Science.gov (United States)

Objective criteria for evaluating the Eysenck Personality Inventory's internal structure are discussed. An approach based on targeted rotations and the test's scoring key is proposed as a means of providing common criteria. Data from earlier structure and test results for 195 undergraduates support the utility of 3 criteria developed. (SLD)

Helmes, Edward

1989-01-01

240

An atlas improves interobserver agreement regarding application of the ISCD vertebral body exclusion criteria.  

Science.gov (United States)

Coexisting conditions such as osteoarthritis and compression fracture may spuriously elevate the dual-energy X-ray absorptiometry (DXA)-measured lumbar spine bone mass. To improve the diagnostic utility of lumbar spine DXA to diagnose osteoporosis, the International Society for Clinical Densitometry (ISCD) suggests excluding vertebrae affected by focal structural anomalies or unusual T-score discrepancies. However, we previously demonstrated only moderate agreement between physicians regarding vertebral body exclusion. We hypothesized that an atlas containing examples of vertebrae to exclude would improve interobserver agreement. Subsequently, we developed an interactive web-based atlas of lumbar spine DXA images with options to exclude vertebrae and compare one's answers to those derived by group consensus. Before and after review of the atlas, 5 ISCD-certified physicians applied the exclusion criteria to 90 DXA scans, recording the indications for vertebral exclusion on a standardized worksheet. After development and review of the atlas, interobserver agreement regarding vertebral body exclusion improved significantly (p<0.0001). We plotted the deviation of each physician's reported T-score vs the mean T-score for each of 90 scans, and demonstrated that the scatter from the mean is decreased after atlas review. Furthermore, correlations in T-score improved in 7 of 10 physician pairs after atlas review. We conclude that an interactive atlas promotes uniform lumbar spine DXA interpretation. PMID:17993400

Hansen, Karen E; Binkley, Neil; Blank, Robert D; Krueger, Diane C; Christian, Rose C; Malone, Daniel G; Baim, Sanford

2007-01-01

241

Rethinking Convenience Sampling: Defining Quality Criteria  

OpenAIRE

Convenience sampling is one of the most commonly used sampling procedures in second language acquisition studies, but this non-random sampling procedure suffers from a lot of problems including the inability of controlling for initial differences between experimental and control groups. The present study tries to introduce conditions and criteria which enable researchers to account for these drawbacks and at the same time make validity claims. Individual scores and group statistics are compar...

Farahman Farrokhi; Asgar Mahmoudi-Hamidabad

2012-01-01

242

Influence of low-stress handling on reactivity score and pregnancy rate during fixed-time artificial insemination in Nellore cows  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The objective of this work was to evaluate the influence of low-stress handling (LSH) on reactivity score and pregnancy rate during fixed-time artificial insemination (FTAI) for extensively raised Nellore cows. Multiparous cows (n = 126) were randomly allocated into two groups: G1 (n = 66) and G2, t [...] he control group (n = 60). Group G1 was subjected to LSH, in which the animals were handled in a calm and quiet manner, without loud noises or physical aggression, using the point of balance, respecting the flight zone and using flags to supplement handling. Group G2 was handled following the typical procedure, with yelling, kicking and the use of electric prods and sticks. On D0, D8 and D10, FTAI was performed in both groups. Reactivity was scored on D0, D8 and D10 at the squeeze chute, based on the tension score, breathing score, and bellowing score. Using the three criteria above, the reactivity scores were defined as follows: R1 (calm); R2 (slightly reactive); R3 (moderately reactive); R4 (reactive); and R5 (highly reactive). Thirty-five days after artificial insemination, pregnancy was determined using ultrasonography. There was no significant correlation between reactivity score and pregnancy rate in each group or between the pregnancy rates in both groups. However, there was a statistically significant difference between the G1 and G2 groups with regard to reactivity score (1.62±0.05 vs. 2.12±0.07). Low-stress handling influenced reactivity but did not affect pregnancy rate in extensively raised Nellore cows subjected to FTAI.

Rayf Roberto, Tirloni; Fábio Alcântara, Rocha; Fábio José, Lourenço; Lílian Rigatto, Martins.

2013-07-01

243

Skyrocketing Scores: An Urban Legend  

Science.gov (United States)

A new urban legend claims, "As a result of the state dropping bilingual education, test scores in California skyrocketed." Krashen disputes this theory, pointing out that other factors offer more logical explanations of California's recent improvements in SAT-9 scores. He discusses research on the effects of California's Proposition 227, which…

Krashen, Stephen

2005-01-01

244

Extended score interval in the assessment of basic surgical skills  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: The Basic Surgical Skills course uses an assessment score interval of 0–3. An extended score interval, 1–6, was proposed by the Swedish steering committee of the course. The aim of this study was to analyze the trainee scores in the current 0–3 scored version compared to a proposed 1–6 scored version. Methods: Sixteen participants, seven females and nine males, were evaluated in the current and proposed assessment forms by instructors, observers, and learners themselves during the first and second day. In each assessment form, 17 tasks were assessed. The inter-rater reliability between the current and the proposed score sheets were evaluated with intraclass correlation (ICC with 95% confidence intervals (CI. Results: The distribution of scores for ‘knot tying’ at the last time point and ‘bowel anastomosis side to side’ given by the instructors in the current assessment form showed that the highest score was given in 31 and 62%, respectively. No ceiling effects were found in the proposed assessment form. The overall ICC between the current and proposed score sheets after assessment by the instructors increased from 0.38 (95% CI 0.77–0.78 on Day 1 to 0.83 (95% CI 0.51–0.94 on Day 2. Discussion: A clear ceiling effect of scores was demonstrated in the current assessment form, questioning its validity. The proposed score sheet provides more accurate scores and seems to be a better feedback instrument for learning technical surgical skills in the Basic Surgical Skills course.

Stefan Acosta

2015-01-01

245

Relationship of Medical Students' Admission Interview Scores to Their Dean's Letter Ratings.  

Science.gov (United States)

A study found that the admission interview scores for 62 Dartmouth Medical School (New Hampshire) applicants correlated positively with dean's letter ratings given 4 years later and that interview scores were better predictors of ratings than were total Medical College Admission Test scores or science grade point averages. (Author/MSE)

Hall, Frances R.; And Others

1992-01-01

246

Estimating WISC-III Scores for Special Education Students Using the Dumont-Faro Short Form.  

Science.gov (United States)

Uses the Dumont-Faro short form to estimate the Wechsler Intelligence Scales for Children-III (WISC-III) Full Sale IQ scores for 45 special education students. Results demonstrate that IQ scores were positively correlated with the WISC-III Full Scale scores. However an IQ miscalculation rate of 44% challenges the utility of the Dumont-Faro short…

Comninel, Mary E.; Bordieri, James E.

2001-01-01

247

Clinical performance of two visual scoring systems in detecting and assessing activity status of occlusal caries in primary teeth  

DEFF Research Database (Denmark)

This study aimed to compare the clinical performance of two sets of visual scoring criteria for detecting caries severity and assessing caries activity status in occlusal surfaces. Two visual scoring systems--the Nyvad criteria (NY) and the ICDAS-II including an adjunct system for lesion activity assessment (ICDAS-LAA)--were compared using 763 primary molars of 139 children aged 3-12 years. The examinations were performed by 2 calibrated examiners. A subsample (n = 50) was collected after extraction and histology with 0.1% red methyl dye was performed to validate lesion depth and activity. The reproducibility of the indices was calculated (kappa test) and ROC analysis was performed to assess their validity and related parameters were compared using McNemar's test. The association between the indices and with the histological examination was evaluated using Spearman's correlation coefficient (r(s)). Visual criteria showed excellent reproducibility both regarding severity (NY: 0.94; ICDAS-II: 0.91) and activity(NY: 0.90; LAA: 0.91). The NY and LAA showed good association in caries activity assessment (r(s) = 0.88; 95% CI = 0.86-0.89; p 0.05). Concerning the severity, both indices presented similar validity parameters. At D2 threshold, the sensitivity was higher for NY (NY = 0.87; ICDAS = 0.61, p <0.05). Regarding activity status, NY showed higher specificities and accuracies. In conclusion, NY and ICDAS-II criteria are comparable and present good reproducibility and validity to detect caries lesions and estimate their severities, but the LAA seems to overestimate the caries activity assessment of cavitated lesions compared to NY.

Braga, M M; Ekstrand, K R

2010-01-01

248

Correlation of signal intensity ratio on orbital MRI-TIRM and clinical activity score as a possible predictor of therapy response in Graves' orbitopathy - a pilot study at 1.5 T  

International Nuclear Information System (INIS)

This study seeks to describe the predictive value of the signal intensity ratio (SIR) in magnetic resonance imaging-turbo inversion recovery magnitude (MRI-TIRM) in patients with Graves' orbitopathy (GO) with regard to predictability of therapy response. Included in this prospective pilot study were 36 consecutive patients with GO and 25 control subjects. Patients were clinically assessed according to the European Group on Graves' Orbitopathy recommendations with active GO defined by a clinical activity score (CAS) ? 3. On magnetic resonance (MR) imaging, muscle inflammation was measured with a region of interest set within the brightest extra-ocular muscle both on coronal turbo inversion recovery magnitude (TIRM) and on fat suppressed gadolinium-enhanced T1-weighted sequences. To calculate the SIR, the measured signal intensity was set in proportion to that of the ipsilateral temporalis muscle. Signal intensity ratio in coronal T2-weighted TIRM sequences in either group ranged from 1.22 to 4.92 (mean 2.04) in patients with GO and from 1.18 to 2.4 (mean 1.63) in controls without GO. The observed differences were significant on the TIRM sequences (right eye p = 0.023; left eye p = 0.022), whereas, no significant differences could be detected on the T1-weighted sequences (right eye p = 0.396; left eye p = 0.498). A cut off value of SIR > 2.5 for a CAS ? 4 to discriminate active from inactive patients was statistically calculated. T2 relaxation time is a reliable too. T2 relaxation time is a reliable tool in detecting active GO. The difference in T2-SIR versus T1-SIR is helpful to distinguish inflammatory oedema of the extra ocular muscles from intra-orbital congestion due to reduced venous outflow. (orig.)

249

Neurointerventional Treatment in Acute Stroke. Whom to Treat? (Endovascular Treatment for Acute Stroke: Utility of THRIVE Score and HIAT Score for Patient Selection)  

International Nuclear Information System (INIS)

Purpose: Intra-arterial therapy (IAT) is used increasingly as a treatment option for acute stroke caused by central large vessel occlusions. Despite high rates of recanalization, the clinical outcome is highly variable. The authors evaluated the Houston IAT (HIAT) and the totaled health risks in vascular events (THRIVE) score, two predicting scores designed to identify patients likely to benefit from IAT. Methods: Fifty-two patients treated at the Stavanger University Hospital with IAT from May 2009 to June 2012 were included in this study. We combined the scores in an additional analysis. We also performed an additional analysis according to high age and evaluated the scores in respect of technical efficacy. Results: Fifty-two patients were evaluated by the THRIVE score and 51 by the HIAT score. We found a strong correlation between the level of predicted risk and the actual clinical outcome (THRIVE p = 0.002, HIAT p = 0.003). The correlations were limited to patients successfully recanalized and to patients <80 years. By combining the scores additional 14.3 % of the patients could be identified as poor candidates for IAT. Both scores were insufficient to identify patients with a good clinical outcome. Conclusions: Both scores showed a strong correlation to poor clinical outcome in patients <80 years. The specificity of the scores could be enhanced by combining them. Both scores were insufficient to identify patients with a good clinical outcome and showed no association to clinical outcome in patients aged ?80 years

250

Neurointerventional Treatment in Acute Stroke. Whom to Treat? (Endovascular Treatment for Acute Stroke: Utility of THRIVE Score and HIAT Score for Patient Selection)  

Energy Technology Data Exchange (ETDEWEB)

Purpose: Intra-arterial therapy (IAT) is used increasingly as a treatment option for acute stroke caused by central large vessel occlusions. Despite high rates of recanalization, the clinical outcome is highly variable. The authors evaluated the Houston IAT (HIAT) and the totaled health risks in vascular events (THRIVE) score, two predicting scores designed to identify patients likely to benefit from IAT. Methods: Fifty-two patients treated at the Stavanger University Hospital with IAT from May 2009 to June 2012 were included in this study. We combined the scores in an additional analysis. We also performed an additional analysis according to high age and evaluated the scores in respect of technical efficacy. Results: Fifty-two patients were evaluated by the THRIVE score and 51 by the HIAT score. We found a strong correlation between the level of predicted risk and the actual clinical outcome (THRIVE p = 0.002, HIAT p = 0.003). The correlations were limited to patients successfully recanalized and to patients <80 years. By combining the scores additional 14.3 % of the patients could be identified as poor candidates for IAT. Both scores were insufficient to identify patients with a good clinical outcome. Conclusions: Both scores showed a strong correlation to poor clinical outcome in patients <80 years. The specificity of the scores could be enhanced by combining them. Both scores were insufficient to identify patients with a good clinical outcome and showed no association to clinical outcome in patients aged {>=}80 years.

Fjetland, Lars, E-mail: lars.fjetland@lyse.net; Roy, Sumit, E-mail: sumit.roy@sus.no; Kurz, Kathinka D., E-mail: kathinka.dehli.kurz@sus.no [Stavanger University Hospital, Department of Radiology (Norway); Solbakken, Tore, E-mail: tore.solbakken@sus.no [Stavanger University Hospital, Department of Neurology (Norway); Larsen, Jan Petter, E-mail: jan.petter.larsen@sus.no; Kurz, Martin W., E-mail: martin.kurz@sus.no [The Norwegian Center for Movement Disorders, Stavanger University Hospital (Norway)

2013-10-15

251

Estimativas de correlações genéticas entre escores visuais e características de carcaça medidas por ultrassonografia em bovinos Nelore utilizando modelos bayesianos linear-limiar Genetic correlation estimates between visual scores and carcass traits measured by ultrasound in Nelore cattle using linear-threshold bayesian models  

Directory of Open Access Journals (Sweden)

Full Text Available O objetivo neste estudo foi estimar as correlações genéticas entre escores visuais e características de carcaça medidas por ultrassonografia em bovinos da raça Nelore utilizando a estatística bayesiana por meio da Amostragem de Gibbs, sob modelo animal linear-limiar. Foram estudadas as características categóricas morfológicas de musculosidade, estrutura física, conformação e sacro, avaliadas aos 15 e 22 meses de idade. Para as características de carcaça, foram avaliadas as características área de olho-de-lombo, espessura de gordura subcutânea, espessura de gordura subcutânea na garupa e altura na garupa. Os escores visuais devem ser empregados como critérios de seleção para aumentar o progresso genético para a característica área de olhode-lombo e, consequentemente, melhorar o rendimento de carcaça. As estimativas de correlação genética obtidas para musculosidade com espessura de gordura subcutânea e espessura de gordura subcutânea na garupa indicaram que a seleção para musculosidade pode levar a animais com melhor acabamento de carcaça. A seleção para a estrutura física e conformação aos 15 e 22 meses de idade pode promover resposta correlacionada para o aumento da altura na garupa.The objective of this study was to estimate the genetic correlations between visual scores and the carcass traits measured by ultrasound, in Nellore breed cattle, using the bayesian statistics by Gibbs Sampling, in the linear-threshold model. The morphological categorical traits of musculature, physical structure, conformation and sacrum were studied, evaluated at 15 and 22 months. The carcass traits of the longissimus muscle area, backfat thickness, rump fat thickness and hip height were evaluated. Visual scores should be used as selection criterion to increase genetic progress for the longissumus muscle area. The estimates of genetic correlations obtained between musculature and backfat thickness and rump fat thickness indicated that the selection for musculature may lead to animals with better carcass finishing. Selection for physical structure and conformation, at 15 and 22 months, should promote response correlated with the hip height.

Carina Ubirajara de Faria

2009-11-01

252

Grado de correlación en la percepción de la dinámica familiar entre ambos padres de preescolares que acuden a Guarderías del DIF Jalisco / Correlation of the family dinamic score between fathers and mothers of preschool children attending the integral development of the family system (DIF) of Guadalajara, Jalisco (Mexico)  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish Introducción. Objetivo: identificar la correlación entre la calificación de dinámica familiar de papá y mamá de preescolares que acuden a Guarderías del Sistema Nacional del Desarrollo Integral de la Familia Jalisco. Material y métodos. Estudio transversal analítico. Se incluyeron 138 encuestas de d [...] inámica familiar aplicadas a ambos padres. Se utilizó un instrumento de medición con 8 áreas: I. Dinámica de pareja; II. Formación de identidad; III. Comunicación, expresión, solidaridad; IV. Estructura de autoridad; V. Manejo del conflicto y agresividad;VI. Disciplina y método; VII. Sistema de Valores; VIII.Aislamiento e integración sociocultural. Resultados. No hubo diferencia en la calificación entre ambos padres ni entre los promedios de las 8 áreas. Hubo una correlación significativa entre ambos padres (r = 0.759, P Abstract in english Introduction. Objective: to test the correlation of the family dynamic score between fathers and mothers of preschool children attending the Integral Development of the Family System (DIF) of Guadalajara City. Material and methods. In a cross sectional study design 140 family dynamic surveys were in [...] cluded. Eight areas of the dynamic of the family of both parents were explored: I. Dynamic of the couple; II. Formation of identity; III. Communication, expression and solidarity; IV. Structure of the authority;V. Management of the conflict and aggressiveness;VI. Discipline and method;VII. System of values;VIII. Socio cultural integration and isolation. Results. There were not differences between fathers and mothers in the eight explored areas.The score of fathers and mothers had a significant correlation (r =0.759). Area I had the higher correlation with the rest of the areas (P

Francisco, Nápoles-Rodríguez; Angélica, Cevallos-González; Eva, Sánchez-Talamantes; José Luis, González-Rico; Enrique, Romero-Velarde; Edgar M., Vásquez-Garibay.

2005-06-01

253

Effects of credit scores on consumer payment choice  

OpenAIRE

This paper investigates the effects of credit scores on consumer payment behavior, especially on debit and credit card use. Anecdotally, a negative relationship between debit card use and credit score has been reported; however, it is not clear whether that relationship is related to other factors, such as education or income, or whether it is a mere correlation. We use a new consumer survey dataset to examine whether this negative relationship holds after controlling for various consumer cha...

Hayashi, Fumiko; Stavins, Joanna

2012-01-01

254

Trace-Based Weighting Approach for Multiple Criteria Decision Making  

Directory of Open Access Journals (Sweden)

Full Text Available Decision-making has evolved as an interesting research problem for decision community. We consider a decision problem that takes into account several criteria called Multiple Criteria Decision Making (MCDM in an interactive application for adaptive execution. In this paper, we present a method for automatically weighting criteria generation based on users’ traces. In our method, we suggest a process that contains all steps describing alternately what is necessary to prepare in order to weight all criteria. We propose a modified method using Naïve Bayes network to exploit the traces (the past of users, there will be used as information for estimating the score of criteria. Experimental results are presented to illustrate a full process and an automatic generation of weighting criteria by a set of values.

Hoang Nam Ho

2014-08-01

255

Unified EEG terminology and criteria for nonconvulsive status epilepticus  

DEFF Research Database (Denmark)

The diagnosis of nonconvulsive status epilepticus (NCSE) relies largely on electroencephalography (EEG) findings. The lack of a unified EEG terminology, and of evidence-based EEG criteria, leads to varying criteria for and ability to diagnose NCSE. We propose a unified terminology and classification system for NCSE, using, as a template, the Standardised Computer-based Organised Reporting of EEG (SCORE). This approach integrates the terminology recently proposed for the rhythmic and periodic patterns in critically ill patients, the electroclinical classification of NCSE (type of NCSE) and the context for the pathologic conditions and age-related epilepsy syndromes. We propose flexible EEG criteria that employ the SCORE system to assemble a database for determining evidence-based EEG criteria for NCSE.

Beniczky, Sándor; Hirsch, Lawrence J

2013-01-01

256

piano_prosthesis: indicative score  

OpenAIRE

This score can be used as a creative starting point, as a open-form score that defines all materials you use, or ignored. The overall aim is to establish clearly differentiated musical materials, characterised by pitch, loudness, density, rhythmic activity, sustained-ness and the degree of internal variation (within a timeframe of 10-20 sec.) Having decided upon materials, either in advance or during the performance, the improvisation should focus on recalling and varying these types. Sile...

Young, Michael W.

2009-01-01

257

Maximum-Score Diversity Selection  

OpenAIRE

Diese Dissertation behandelt das Maximum-Score Diversity Selection (MSDS) Problem. Reine Diversitätsauswahl, wie sie bereits häufig z.B. in der frühen Wirkstoffforschung in der Pharmaindustrie eingesetzt wird, ist die Auswahl einer Teilmenge von Objekten die möglichst divers ist. MSDS führt ein zweites Kriterium ein, das neben der Optimierung der Diversität, auch die Bewertung ("score'') der Teilmenge optimieren soll (in der Regel die Summe der Bewertungen der einzelnen Objekte). Diese ...

Meinl, Thorsten

2010-01-01

258

The examination of the relationship between YGS scores and music field scores in music teaching programme with special talent examination  

OpenAIRE

Every year, with special aptitude exams students are taken to undergraduate programs as a music teacher in Turkey .Although applications for these exam show differences according to the difficulty level of the questions and evaluations criterias, all the areas that would be measured show similarities to each other. The areas showing the similarity are classified as Musical hearing-reading-writing fields (M?OY) , musical playing area and musical singing area. Special Ability Test score (ÖY...

Turan Sa?er; Onur Zahal; Engin Gürp?nar

2013-01-01

259

Knowledge management review criteria  

International Nuclear Information System (INIS)

The paper presents knowledge management review criteria, which are intended to be used by a nuclear power plant operating organization in conducting a self-assessment or an external review of knowledge management functions. Most of these criteria have been used by IAEA experts during the missions on knowledge management at Krsko nuclear power plant, Slovenia and Kozloduy nuclear power plant, Bulgaria. (author)

260

Docking and scoring of metallo-beta-lactamases inhibitors  

DEFF Research Database (Denmark)

The performance of the AutoDock, GOLD and FlexX docking programs was evaluated for docking of dicarboxylic acid inhibitors into metallo-beta-lactamases (MBLs). GOLD provided the best overall performance, with RMSDs between experimental and docked structures of 1.8-2.6 A and a good correlation between the experimentally determined MBL-inhibitor affinities and the GOLD scores. GOLD was selected for a test including a broad spectrum of inhibitors for which experimental MBL-inhibitor binding affinities are available. This study revealed that (1) for most compound classes (dicarboxylic acids, tetrazoles, sulfonylhydrazones, and peptide-like compounds) there is a good correlation between the experimentally determined MBL-inhibitor affinities and the GOLD scores, (2) the correlation only holds within a given class, that is, scores of compounds from different classes cannot be directly compared, (3) for some compound classes (e.g. small sulphur compounds) there is no direct correlation between the experimentally determined MBL-inhibitor affinities and the GOLD scores. Using partial least squares methods, a model with R2 = 0.82 and Q2 = 0.78 for the training set was obtained based on the GOLD score and descriptors associated with binding of the IMP-1 inhibitors to the enzyme. The external Q2 for the test set is 0.73. This final model for prediction of IMP-1 MBL-inhibitor affinity handled all known classes of MBL-inhibitors, except small sulphur compounds.

Olsen, Lars; Pettersson, Ingrid

2004-01-01

261

Plutonium storage criteria  

Energy Technology Data Exchange (ETDEWEB)

The Department of Energy has issued a technical standard for long-term (>50 years) storage and will soon issue a criteria document for interim (<20 years) storage of plutonium materials. The long-term technical standard, {open_quotes}Criteria for Safe Storage of Plutonium Metals and Oxides,{close_quotes} addresses the requirements for storing metals and oxides with greater than 50 wt % plutonium. It calls for a standardized package that meets both off-site transportation requirements, as well as remote handling requirements from future storage facilities. The interim criteria document, {open_quotes}Criteria for Interim Safe Storage of Plutonium-Bearing Solid Materials{close_quotes}, addresses requirements for storing materials with less than 50 wt% plutonium. The interim criteria document assumes the materials will be stored on existing sites, and existing facilities and equipment will be used for repackaging to improve the margin of safety.

Chung, D. [Scientech, Inc., Germantown, MD (United States); Ascanio, X. [Dept. of Energy, Germantown, MD (United States)

1996-05-01

262

The value of CT score in predicting surgical methods and difficulty of hepatic cystic echinococcosis  

International Nuclear Information System (INIS)

Objective: To evaluate the value of MSCT scores on surgery method selection and its difficulty estimation for hepatic cystic echinococcosis. Methods: Based on the CT features of hepatic cystic echinococcosis (HCE), an integral system including 7 items was established. Images of preoperative CT examination performed on 71 cases of hepatic cystic echinococcosis were retrospectively analyzed by the integral system and compared with actual surgical. Total 93 cystic lesions were divided into 3 groups based on CT scores: Group A suitable for total cystectomy (0 to 5 score), Group B suitable for subtotal cystectomy (6 to 10 score), and Group C suitable forendocystectomy ( ? 11 scores, or 4 score in one item), Spearman rank correlation was used to analyze the relationship between WHO classification of cystic echinococcosis and actual surgery methods, the relationship between operation mode forecasted by CT scores and actual surgery methods, the relationship between vessel scores of cyst and actual surgery methods, and that between biliary score of cyst and actual surgery methods. Fisher exact test and Chi-square test were used to evaluate the incidence of residual cavity in patients with different biliary scores. Results: Thirty nine cysts got 0 to 5 scores, 45 cysts got 6 to 10 scores and 9 cysts got more than 10 scores. Total cystectomy was performed on 30 cysts, subtotal cystectomy on 40 cysts and performed endocystectomy on 23 cysts, actually. Actual operation methods were correlated with that predicated by CT scores (r=0.741, P<0.01), and with vessels score and biliary score (r=0.587, 0.327 respectively, P<0.01). The higher the biliary score, the higher the incidence of postoperative biliary tract complications. Conclusions: Preoperative CT scoring was an easy and objective way to accurately predict the surgery methods and its difficulty for hepatic cystic echinococcosis. (authors)

263

Testing of the OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage in rheumatoid arthritis: a systematic literature search on 5 candidate biomarkers  

DEFF Research Database (Denmark)

OBJECTIVE: To test the OMERACT 8 draft validation criteria for soluble biomarkers by assessing the strength of literature evidence in support of 5 candidate biomarkers. METHODS: A systematic literature search was conducted on the 5 soluble biomarkers RANKL, osteoprotegerin (OPG), matrix metalloprotease (MMP-3), urine C-telopeptide of types I and II collagen (U-CTX-I and U CTX-II), focusing on the 14 OMERACT 8 criteria. Two electronic voting exercises were conducted to address: (1) strength of evidence for each biomarker as reflecting structural damage according to each individual criterion and the importance of each individual criterion; (2) overall strength of evidence in support of each of the 5 candidate biomarkers as reflecting structural damage endpoints in rheumatoid arthritis (RA) and identification of omissions to the criteria set. RESULTS: The search identified 111 articles. The strength of evidence in support of these biomarkers reflecting structural damage was low for all biomarkers and was rated highest for U-CTX-II [score of 6.5 (numerical rating scale 0-10)]. The lowest scores for retention of specific criteria in the draft set went to criteria that refer to the importance of animal studies, correlations with other biomarkers reflecting damage, and an understanding of the metabolism of the biomarker. CONCLUSION: Evidence in support of any of the 5 tested biomarkers (MMP-3, CTX-I, CTX-II, OPG, RANKL) was inadequate to allow their substitution for radiographic endpoints in RA. Three of the criteria in the draft criteria set might not be required, but few omissions were identified.

Syversen, Silje W; Landewe, Robert

2009-01-01

264

Development of a software tool and criteria evaluation for efficient design of small interfering RNA  

Energy Technology Data Exchange (ETDEWEB)

Research highlights: {yields} The developed tool predicted siRNA constructs with better thermodynamic stability and total score based on positional and other criteria. {yields} Off-target silencing below score 30 were observed for the best siRNA constructs for different genes. {yields} Immunostimulation and cytotoxicity motifs considered and penalized in the developed tool. {yields} Both positional and compositional criteria were observed to be important. -- Abstract: RNA interference can be used as a tool for gene silencing mediated by small interfering RNAs (siRNA). The critical step in effective and specific RNAi processing is the selection of suitable constructs. Major design criteria, i.e., Reynolds's design rules, thermodynamic stability, internal repeats, immunostimulatory motifs were emphasized and implemented in the siRNA design tool. The tool provides thermodynamic stability score, GC content and a total score based on other design criteria in the output. The viability of the tool was established with different datasets. In general, the siRNA constructs produced by the tool had better thermodynamic score and positional properties. Comparable thermodynamic scores and better total scores were observed with the existing tools. Moreover, the results generated had comparable off-target silencing effect. Criteria evaluations with additional criteria were achieved in WEKA.

Chaudhary, Aparna; Srivastava, Sonam [Department of Chemical Engineering, IIT Kanpur, UP 208 016 (India); Garg, Sanjeev, E-mail: sgarg@iitk.ac.in [Department of Chemical Engineering, IIT Kanpur, UP 208 016 (India)

2011-01-07

265

Development of a software tool and criteria evaluation for efficient design of small interfering RNA  

International Nuclear Information System (INIS)

Research highlights: ? The developed tool predicted siRNA constructs with better thermodynamic stability and total score based on positional and other criteria. ? Off-target silencing below score 30 were observed for the best siRNA constructs for different genes. ? Immunostimulation and cytotoxicity motifs considered and penalized in the developed tool. ? Both positional and compositional criteria were observed to be important. -- Abstract: RNA interference can be used as a tool for gene silencing mediated by small interfering RNAs (siRNA). The critical step in effective and specific RNAi processing is the selection of suitable constructs. Major design criteria, i.e., Reynolds's design rules, thermodynamic stability, internal repeats, immunostimulatory motifs were emphasized and implemented in the siRNA design tool. The tool provides thermodynamic stability score, GC content and a total score based on other design criteria in the output. The viability of the tool was established with different datasets. In general, the siRNA constructs produced by the tool had better thermodynamic score and positional properties. Comparable thermodynamic scores and better total scores were observed with the existing tools. Moreover, the results generated had comparable off-target silencing effect. Criteria evaluations with additional criteria were achieved in WEKA.

266

Reproducibility of scoring emphysema by HRCT  

International Nuclear Information System (INIS)

Purpose: We evaluated the reproducibility of three visual scoring methods of emphysema and compared these methods with pulmonary function tests (VC, DLCO, FEV1 and FEV%) among farmer's lung patients and farmers. Material and Methods: Three radiologists examined high-resolution CT images of farmer's lung patients and their matched controls (n=70) for chronic interstitial lung diseases. Intraobserver reproducibility and interobserver variability were assessed for three methods: severity, Sanders' (extent) and Sakai. Pulmonary function tests as spirometry and diffusing capacity were measured. Results: Intraobserver -values for all three methods were good (0.51-0.74). Interobserver varied from 0.35 to 0.72. The Sanders' and the severity methods correlated strongly with pulmonary function tests, especially DLCO and FEV1. Conclusion: The Sanders' method proved to be reliable in evaluating emphysema, in terms of good consistency of interpretation and good correlation with pulmonary function tests

267

Reproducibility of scoring emphysema by HRCT  

Energy Technology Data Exchange (ETDEWEB)

Purpose: We evaluated the reproducibility of three visual scoring methods of emphysema and compared these methods with pulmonary function tests (VC, DLCO, FEV1 and FEV%) among farmer's lung patients and farmers. Material and Methods: Three radiologists examined high-resolution CT images of farmer's lung patients and their matched controls (n=70) for chronic interstitial lung diseases. Intraobserver reproducibility and interobserver variability were assessed for three methods: severity, Sanders' (extent) and Sakai. Pulmonary function tests as spirometry and diffusing capacity were measured. Results: Intraobserver -values for all three methods were good (0.51-0.74). Interobserver varied from 0.35 to 0.72. The Sanders' and the severity methods correlated strongly with pulmonary function tests, especially DLCO and FEV1. Conclusion: The Sanders' method proved to be reliable in evaluating emphysema, in terms of good consistency of interpretation and good correlation with pulmonary function tests.

Malinen, A.; Partanen, K.; Rytkoenen, H.; Vanninen, R. [Kuopio Univ. Hospital (Finland). Dept. of Clinical Radiology; Erkinjuntti-Pekkanen, R. [Kuopio Univ. Hospital (Finland). Dept. of Pulmonary Diseases

2002-04-01

268

Estimating Decision Indices Based on Composite Scores  

Science.gov (United States)

The purpose of this study was to develop an IRT model that would enable the estimation of decision indices based on composite scores. The composite scores, defined as a combination of unidimensional test scores, were either a total raw score or an average scale score. Additionally, estimation methods for the normal and compound multinomial models…

Knupp, Tawnya Lee

2009-01-01

269

Fire protection design criteria  

Energy Technology Data Exchange (ETDEWEB)

This Standard provides supplemental fire protection guidance applicable to the design and construction of DOE facilities and site features (such as water distribution systems) that are also provided for fire protection. It is intended to be used in conjunction with the applicable building code, national Fire Protection Association Codes and Standards, and any other applicable DOE construction criteria. This Standard, along with other delineated criteria, constitutes the basic criteria for satisfying DOE fire and life safety objectives for the design and construction or renovation of DOE facilities.

NONE

1997-03-01

270

Use of e-rater[R] in Scoring of the TOEFL iBT[R] Writing Test. Research Report. ETS RR-11-25  

Science.gov (United States)

Alternative approaches are discussed for use of e-rater[R] to score the TOEFL iBT[R] Writing test. These approaches involve alternate criteria. In the 1st approach, the predicted variable is the expected rater score of the examinee's 2 essays. In the 2nd approach, the predicted variable is the expected rater score of 2 essay responses by the…

Haberman, Shelby J.

2011-01-01

271

Video National Imagery Interpretability Rating Scale criteria survey results  

Science.gov (United States)

The Video National Imagery Interpretability Rating Standard (V-NIIRS) consists of a ranked set of subjective criteria to assist analysts in assigning an interpretability quality level to a motion imagery clip. The V-NIIRS rating standard is needed to support the tasking, retrieval, and exploitation of motion imagery. A criteria survey was conducted to yield individual pair-wise criteria rankings and scores. Statistical analysis shows good agreement with expectations across the 9-levels of interpretability, for each of the 7 content domains.

Young, Darrell; Yen, James; Petitti, Fred; Bakir, Tariq; Brennan, Michelle; Butto, Robert, Jr.

2009-05-01

272

Interobserver agreement for diagnostic MRI criteria in suspected multiple sclerosis  

International Nuclear Information System (INIS)

MRI is the paraclinical test most widely used to support the diagnosis of multiple sclerosis (MS). We evaluated interobserver agreement in applying diagnostic criteria to MRI obtained at first presentation. Five experienced observers scored 25 sets of images consisting of unenhanced T2- and gadolinium-enhanced T1-weighted images (approximately half the sets were normal). We scored frontal, parietal, temporal, occipital, infratentorial and basal ganglia lesions and the total number of lesions on T2-weighted images; periventricular, callosal, juxtacortical and ovoid lesions and those > 5 mm in maximum diameter; contrast-enhancing and hypointense lesions. Based on a combination of imaging findings patients were classified as compatible or not compatible with MS according to composite criteria. Observer concordance was characterised by weighted kappa values (?) and mean average difference to the median (MADM) scores. Using the raw scores, there was poor agreement for the total number of lesions on T2-weighted images, and for occipital, oval, juxtacortical and hypointense lesions. Moderate agreement was found for frontal, callosal, basal ganglia and large lesions on T2 weighting. Good agreement was attained for parietal, temporal, infratentorial and periventricular lesions. After dichotomisation according to accepted cut-off values, most criteria performed better, especially the number of lesions on T2-weighted images (P < 0.05). Good agreement was found for the criteria ood agreement was found for the criteria of Paty and Fazekas and moderate agreement for those of Barkhof. While experienced observers may not agree on the total number of lesions, they show quite good agreement for commonly used cut-off points and elements in the composite criteria. This validates the use of MRI in the diagnosis of MS, and the use of dichotomised and composite criteria. (orig.)

273

Meteor Stream Membership Criteria  

OpenAIRE

Criteria for the membership of individual meteors in meteor streams are discussed from the point of view of their mathematical and also physical properties. Discussion is also devoted to the motivation. It is shown that standardly used criteria (mainly D-criterion of Southworth and Hawkins, 1963) have unusual mathematical properties in the sense of a term ``distance'', between points in a phase space, and, physical motivation and realization for the purpose of obtaining thei...

Klacka, Jozef

2000-01-01

274

Do medical students’ scores using different assessment instruments predict their scores in clinical reasoning using a computer-based simulation?  

Directory of Open Access Journals (Sweden)

Full Text Available Mariam Fida,1 Salah Eldin Kassab2 1Department of Molecular Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain; 2Department of Medical Education, Faculty of Medicine, Suez Canal University, Ismailia, Egypt Purpose: The development of clinical problem-solving skills evolves over time and requires structured training and background knowledge. Computer-based case simulations (CCS have been used for teaching and assessment of clinical reasoning skills. However, previous studies examining the psychometric properties of CCS as an assessment tool have been controversial. Furthermore, studies reporting the integration of CCS into problem-based medical curricula have been limited. Methods: This study examined the psychometric properties of using CCS software (DxR Clinician for assessment of medical students (n=130 studying in a problem-based, integrated multisystem module (Unit IX during the academic year 2011–2012. Internal consistency reliability of CCS scores was calculated using Cronbach's alpha statistics. The relationships between students' scores in CCS components (clinical reasoning, diagnostic performance, and patient management and their scores in other examination tools at the end of the unit including multiple-choice questions, short-answer questions, objective structured clinical examination (OSCE, and real patient encounters were analyzed using stepwise hierarchical linear regression. Results: Internal consistency reliability of CCS scores was high (?=0.862. Inter-item correlations between students' scores in different CCS components and their scores in CCS and other test items were statistically significant. Regression analysis indicated that OSCE scores predicted 32.7% and 35.1% of the variance in clinical reasoning and patient management scores, respectively (P<0.01. Multiple-choice question scores, however, predicted only 15.4% of the variance in diagnostic performance scores (P<0.01, while students’ scores in real patient encounters did not predict any of the CCS scores. Conclusion: Students’ scores in OSCE are the most important predictors of their scores in clinical reasoning and patient management using CCS. However, real patient encounter assessment does not appear to test a construct similar to what is tested in CCS. Keywords: medical education, computer-based simulations, virtual patients, student assessment, PBL, Bahrain

Fida M

2015-02-01

275

Scoring of the Physical Therapist Clinical Performance Instrument (PT-CPI): Analysis of 7 Years of Use  

OpenAIRE

Purpose: The aims of this study were to (1) describe the completion rates of the 24 performance criteria (PCs) from the Physical Therapist Clinical Performance Instrument (PT-CPI) by clinical instructors; (2) evaluate change in PC visual analogue scores (VAS) with students' clinical experience; and (3) evaluate scoring patterns over time.

Proctor, Peggy L.; Dal Bello-haas, Vanina P.; Mcquarrie, Arlis M.; Sheppard, M. Suzanne; Scudds, Rhonda J.

2010-01-01

276

Validation of Automated Scores of TOEFL iBT Tasks against Non-Test Indicators of Writing Ability  

Science.gov (United States)

Automated scoring has the potential to dramatically reduce the time and costs associated with the assessment of complex skills such as writing, but its use must be validated against a variety of criteria for it to be accepted by test users and stakeholders. This study approaches validity by comparing human and automated scores on responses to…

Weigle, Sara Cushing

2010-01-01

277

Seniors Increase Scores on NAEP  

Science.gov (United States)

The latest administration of the assessment provides state-by-state results for 12th graders for the first time. Twelfth graders' reading and mathematics scores on the National Assessment of Educational Progress have improved only modestly in the past four years, according to results from the latest administration, prompting renewed recognition…

Gewertz, Catherine

2010-01-01

278

Correlação entre Inventário de Depressão de Beck e cortisol urinário em diabéticos tipo 2 / Correlation between urine cortisol and scores on the Beck Depression inventory in patients with type 2 diabetes / Correlación entre el inventario de Depresión de Beck y el cortisol urinario en diabeticos tipo 2  

Scientific Electronic Library Online (English)

Full Text Available OBJETIVO: Verificar a correlação entre o cortisol urinário e o Inventário de Depressão de Beck em diabéticos do tipo 2. MÉTODOS: O cortisol urinário foi avaliado em uma amostra composta por 40 pacientes da Liga de Controle de Diabetes da Disciplina de Endocrinologia do Hospital das Clínicas da Facul [...] dade de Medicina da Universidade de São Paulo e para a avaliação dos sintomas de depressão foi aplicado o Inventário de Depressão de Beck. RESULTADOS: Alta confiabilidade para o Inventário de Depressão de Beck(Alfa de Cronbach=0,920)e correlação significativa foi observada entre cortisol urinário e Inventário de Depressão de Beck(Spearman,r=0.523,p Abstract in spanish OBJETIVO: Verificar la correlación entre el cortisol urinario y el Inventario de Depresión de Beck en diabéticos del tipo 2. MÉTODOS: El cortisol urinario fue evaluado en una muestra compuesta por 40 pacientes de la Liga de Control de Diabetes de la Disciplina de Endocrinología del Hospital de las C [...] línicas de la Facultad de Medicina de la Universidad de Sao Paulo y para la evaluación de los síntomas de depresión fue aplicado el Inventario de Depresión de Beck. RESULTADOS: Alta confiabilidad para el Inventario de Depresión de Beck(Alfa de Cronbach=0,920) y correlación significativa observada entre el cortisol urinario e Inventario de Depresión de Beck (Spearman,r=0.523,p Abstract in english OBJECTIVE: To determine the relationship between urinary cortisol and scores on the Beck Depression Inventory in type 2 diabetics. METHODS: The sample consisted of 40 patients with type 2 diabetes from the diabetes control league of the discipline of endocrinology of the HCFM-USP. Measures consisted [...] of urinary cortisol and depression symptoms using the Beck Depression Inventory. RESULTS: The Beck Depression Inventory had a Cronbach's alpha of 0.92. There was a statistically significant correlation between urinary cortisol and scores on the Beck Depression Inventory (Spearman r = 0.52, p

Alexandra Bulgarelli do, Nascimento; Eliane Corrêa, Chaves; Sônia Aurora Alves, Grossi; Simão Augusto, Lottenberg.

279

Evaluation of the association between AT1R1166C polymorphism and the incidence of cad and CAC score in the Iranian population  

Directory of Open Access Journals (Sweden)

Full Text Available Most of the physiological effects of Ag II are mediated by the angiotensin II type 1 receptor. Polymorphisms of the AT1R gene can affect the function of this receptor and subsequent atherogenic activity. In this study we investigated the correlation between AT1R A1166C polymorphism and coronary artery calcification (CAC, a marker of the coronary artery burden. Fifty CAD patients and fifty healthy individuals fulfilled the inclusion and exclusion criteria entered this study. CAC was determined in the left main coronary artery (LMCA, left coronary artery (LCA, right coronary artery (RCA and CX by CT-angiography and a blood sample was taken at this time. DNA extracted from whole blood leukocytes was analyzed by the polymerase chain reaction - restriction fragment-length polymorphism (PCR-RFLP assay. There were no significant differences in genotype and allele frequencies between the CAD and control groups. The mean calcium score was compared in genotypes and alleles and no significant difference was seen. In addition, the frequency of genotypes and alleles was not significantly different in the calcium score groups (low<100, medium= 100-400, high >400. An analysis was performed separately in males and females and no significant correlation was found. According to our results, no association was found between AT1R1166C polymorphism and the incidence of CAD and CAC score in our study population.

Mohammadpour Hooshang Amir

2012-01-01

280

Assessment of the pathological grade of astrocytic gliomas using an MRI score  

International Nuclear Information System (INIS)

To evaluate the usefulness of an MRI score for identifying tumour tissue characteristics, 41 histologically verified supratentorial astrocytic gliomas, including 13 low-grade astrocytomas 14 anaplastic astrocytomas and 14 glioblastoma multiformes, were examined with a 0.5 T superconductive MR imager. Nine MRI criteria were used: heterogeneity, cyst formation or necrosis, haemorrhage, crossing the midline, oedema or mass effect, border definition, flow void, degree and heterogeneity of contrast enhancement; Gd-enhanced T1-weighted images were obtained in 32 cases. Each of the criteria was scored and analysed statistically. (orig./MG)

281

Acceptance criteria for determining armed response force size at nuclear power plants  

International Nuclear Information System (INIS)

This guidance document contains acceptance criteria to be used in the NRC license review process. It consists of a scored worksheet and guidelines for interpreting the worksheet score that can be used in determining the adequacy of the armed response force size at a nuclear power reactor facility

282

Interobserver agreement for diagnostic MRI criteria in suspected multiple sclerosis.  

Science.gov (United States)

MRI is the paraclinical test most widely used to support the diagnosis of multiple sclerosis (MS). We evaluated interobserver agreement in applying diagnostic criteria to MRI obtained at first presentation. Five experienced observers scored 25 sets of images consisting of unenhanced T2- and gadolinium-enhanced T1-weighted images (approximately half the sets were normal). We scored frontal, parietal, temporal, occipital, infratentorial and basal ganglia lesions and the total number of lesions on T2-weighted images; periventricular, callosal, juxtacortical and ovoid lesions and those > 5 mm in maximum diameter; contrast-enhancing and hypointense lesions. Based on a combination of imaging findings patients were classified as compatible or not compatible with MS according to composite criteria. Observer concordance was characterised by weighted kappa values (kappa) and mean average difference to the median (MADM) scores. Using the raw scores, there was poor agreement for the total number of lesions on T2-weighted images, and for occipital, oval, juxtacortical and hypointense lesions. Moderate agreement was found for frontal, callosal, basal ganglia and large lesions on T2 weighting. Good agreement was attained for parietal, temporal, infratentorial and periventricular lesions. After dichotomisation according to accepted cut-off values, most criteria performed better, especially the number of lesions on T2-weighted images (P < 0.05). Good agreement was found for the criteria of Paty and Fazekas and moderate agreement for those of Barkhof. While experienced observers may not agree on the total number of lesions, they show quite good agreement for commonly used cut-off points and elements in the composite criteria. This validates the use of MRI in the diagnosis of MS, and the use of dichotomised and composite criteria. PMID:10379592

Barkhof, F; Filippi, M; van Waesberghe, J H; Campi, A; Miller, D H; Adèr, H J

1999-05-01

283

Interobserver agreement for diagnostic MRI criteria in suspected multiple sclerosis  

Energy Technology Data Exchange (ETDEWEB)

MRI is the paraclinical test most widely used to support the diagnosis of multiple sclerosis (MS). We evaluated interobserver agreement in applying diagnostic criteria to MRI obtained at first presentation. Five experienced observers scored 25 sets of images consisting of unenhanced T2- and gadolinium-enhanced T1-weighted images (approximately half the sets were normal). We scored frontal, parietal, temporal, occipital, infratentorial and basal ganglia lesions and the total number of lesions on T2-weighted images; periventricular, callosal, juxtacortical and ovoid lesions and those > 5 mm in maximum diameter; contrast-enhancing and hypointense lesions. Based on a combination of imaging findings patients were classified as compatible or not compatible with MS according to composite criteria. Observer concordance was characterised by weighted kappa values ({kappa}) and mean average difference to the median (MADM) scores. Using the raw scores, there was poor agreement for the total number of lesions on T2-weighted images, and for occipital, oval, juxtacortical and hypointense lesions. Moderate agreement was found for frontal, callosal, basal ganglia and large lesions on T2 weighting. Good agreement was attained for parietal, temporal, infratentorial and periventricular lesions. After dichotomisation according to accepted cut-off values, most criteria performed better, especially the number of lesions on T2-weighted images (P < 0.05). Good agreement was found for the criteria of Paty and Fazekas and moderate agreement for those of Barkhof. While experienced observers may not agree on the total number of lesions, they show quite good agreement for commonly used cut-off points and elements in the composite criteria. This validates the use of MRI in the diagnosis of MS, and the use of dichotomised and composite criteria. (orig.) With 2 tabs., 13 refs.

Barkhof, F.; Waesberghe, J.H.T.M. van [Department of Radiology, Academic Hospital of the Vrije Universiteit, Amsterdam (Netherlands); Filippi, M.; Campi, A. [MS Biosignal Analysis Centre, Department of Neurology, Scientific Institute H San Raffaele, University of Milan (Italy); Miller, D.H. [NMR Research Group, Institute of Neurology, Queen Square, London (United Kingdom); Ader, H.J. [Department of Epidemiology and Biostatistics, Vrije Universiteit, Amsterdam (Netherlands)

1999-05-01

284

Shwachman-Kulczycki score still useful to monitor cystic fibrosis severity  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english INTRODUCTION: The Shwachman-Kulczycki score was the first scoring system used in cystic fibrosis to assess disease severity. Despite its subjectivity, it is still widely used. OBJECTIVE: To study correlations among forced expiratory volume in one second (FEV1), chest radiography, chest computed tomo [...] graphy, 6-minute walk test, and Shwachman-Kulczycki score in patients with cystic fibrosis and to test whether the Shwachman-Kulczycki score is still useful in monitoring the severity of the disease. METHODS: A cross-sectional prospective study was performed to analyze the correlations (Spearman). Patients with clinically stable cystic fibrosis, aged 3-21 years, were included. RESULTS: 43 patients, 19F/24M, mean age 10.5 + 4.7 years, with a median Shwachman-Kulczycki score of 70 were studied. The median Brasfield and Bhalla scores were 17 and 10, respectively. The mean Z score for the 6-minute walk test was -1.1 + 1.106 and the mean FEV1 was 59 + 26 (as percentage of predicted values). The following significant correlations versus the Shwachman-Kulczycki score were found: FEV1 (r = 0.76), 6-minute walk test (r = 0.71), chest radiography (r = 0.71) and chest computed tomography (r = -0.78). When patients were divided according to FEV1, a statistically significantly correlation with the Shwachman-Kulczycki score was found only in patients with FEV1

Fabíola, Stollar; Fabíola Villac, Adde; Maristela T., Cunha; Claudio, Leone; Joaquim C., Rodrigues.

285

Neuropathology-Based Risk Scoring for Dementia Diagnosis in the Elderly  

OpenAIRE

Current neuropathologic consensus criteria for diagnosis of dementia yield a classification of processes that likely contributed to dementia in that individual. While dementia diagnosis currently relies on clinical criteria, practicing neuropathologists and researchers might benefit from a simple, accurate risk scoring protocol for the neuropathologic diagnosis of dementia. Using 232 consecutive autopsies from the population-based Adult Changes in Thought study, we developed two logistic regr...

Haneuse, Sebastien; Larson, Eric; Walker, Rod; Montine, Thomas; Sonnen, Joshua

2009-01-01

286

Summarized water quality criteria  

International Nuclear Information System (INIS)

The available world literature from 27 sources on existing water quality criteria are summarized for the 15 main uses of water. The minimum, median and maximum specified values for 96 different determinands are included. Under each water use the criteria are grouped according to the functional significance of the determinands e.g. aesthetic/physical effects, high toxic potential, low toxic potential etc. A synopsis is included summarizing salient facts for each determinand such as the conditions under which it is toxic and its relationship to other determinands. The significance of the criteria is briefly discussed and the importance of considering functional interactions between determinands emphasized in evaluating the potential for toxic or beneficial effects. From the source literature it appears that the toxic potential, in addition to being determined by concentration, is also affected by the origin of the substance concerned, i.e. whether from natural sources or from anthropogenic pollution

287

Lung donor selection criteria.  

Science.gov (United States)

The criteria that define acceptable physiologic and social parameters for lung donation have remained constant since their empiric determination in the 1980s. These criteria include a donor age between 25-40, a arterial partial pressure of oxygen (PaO2)/FiO2 ratio greater than 350, no smoking history, a clear chest X-ray, clean bronchoscopy, and a minimal ischemic time. Due to the paucity of organ donors, and the increasing number of patients requiring lung transplant, finding a donor that meets all of these criteria is quite rare. As such, many transplants have been performed where the donor does not meet these stringent criteria. Over the last decade, numerous reports have been published examining the effects of individual acceptance criteria on lung transplant survival and graft function. These studies suggest that there is little impact of the historical criteria on either short or long term outcomes. For age, donors should be within 18 to 64 years old. Gender may relay benefit to all female recipients especially in male to female transplants, although results are mixed in these studies. Race matched donor/recipients have improved outcomes and African American donors convey worse prognosis. Smoking donors may decrease recipient survival post transplant, but provide a life saving opportunity for recipients that may otherwise remain on the transplant waiting list. No specific gram stain or bronchoscopic findings are reflected in recipient outcomes. Chest radiographs are a poor indicator of lung donor function and should not adversely affect organ usage aside for concerns over malignancy. Ischemic time greater than six hours has no documented adverse effects on recipient mortality and should not limit donor retrieval distances. Brain dead donors and deceased donors have equivalent prognosis. Initial PaO2/FiO2 ratios less than 300 should not dissuade donor organ usage, although recruitment techniques should be implemented with intent to transplant. PMID:25132970

Chaney, John; Suzuki, Yoshikazu; Cantu, Edward; van Berkel, Victor

2014-08-01

288

Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity  

Directory of Open Access Journals (Sweden)

Full Text Available Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. However, there is no gold standard to measure the disease activity in clinical trials. In this study we aimed to introduce the pemphigus vulgaris activity score (PVAS measurement and to assess the convergent validity with the experts’ opinion of disease activity. In PVAS scoring, the distribution of pemphigus vulgaris antigen expression in different anatomical regions is taking in to account with special consideration of the healing process. PVAS is a 0-18 scale, based on the extent of mucocutaneous involvement, type of lesion and the presence of Nikolsky’s sign. The sum of the scores of total number of lesions, number of different anatomic regions involvement and Nikolsky’s sign is weighted by the type of lesion. In the present study, PVAS was assessed in 50 patients diagnosed with pemphigus vulgaris by one dermatologist. Independently, five blinded experts scored all the patients through physician’s global assessment (PGA. The convergent validity with experts’ opinion was assessed. The Spearman coefficient of correlation showed the acceptable value of 0.751 (95%CI: 0.534- 0.876. PVAS is a valid, objective and simple-to-use scoring measurement. It showed a good correlation with PGA of pemphigus disease activity in Iranian patients with pemphigus vulgaris

Cheyda Chams-Davatchi

2013-04-01

289

Lung donor selection criteria  

OpenAIRE

The criteria that define acceptable physiologic and social parameters for lung donation have remained constant since their empiric determination in the 1980s. These criteria include a donor age between 25-40, a arterial partial pressure of oxygen (PaO2)/FiO2 ratio greater than 350, no smoking history, a clear chest X-ray, clean bronchoscopy, and a minimal ischemic time. Due to the paucity of organ donors, and the increasing number of patients requiring lung transplant, finding a donor that me...

Chaney, John; Suzuki, Yoshikazu; Cantu, Edward; Berkel, Victor

2014-01-01

290

Flame temperature criteria tests  

International Nuclear Information System (INIS)

Since the Lewis-Karlovitz flame temperature criteria had been based on data obtained from hydrogen flammability tests using hydrogen-air mixtures at room temperature and atmospheric pressure, a test program was conducted at Fenwal Incorporated to evaluate its applicability to a post-accident containment atmosphere at elevated temperature and pressure. Another objective of this test program was to obtain laminar burning velocities under post-accident containment atmospheric conditions. These velocities are needed for estimating the hydrogen burn time in containments. This paper presents the results obtained from this test program, which are then used to validate the Lewis-Karlovitz flame temperature criteria

291

Developing seismic design criteria  

International Nuclear Information System (INIS)

Considerations in developing seismic design criteria are presented. A diagram is provided on the relationship of the design process and design criteria components. Empirical methods have always played a major role in design of underground openings. However, licensing procedures have served to increase the rigors of seismic analysis, but the state of quantitative methods is not yet as sophisticated for subsurface structures as it is for surface structures. A table of potential damage modes during the operational phase and during the decommissioned phase is presented

292

Digital Scores: Loeb Music Library  

Science.gov (United States)

In 1956, the Loeb Music Library at Harvard University was established as the formal music library of the Harvard University Music Department. While the Library has embarked on a number of ambitious public outreach programs, this particular one will be a delight for musicologists as well as for those who just enjoy perusing unique musical scores. The layout of the site is pretty straightforward: as users scroll down the homepage, they can look over manuscripts from C.P.E. Bach, Mozart, and the vocal scores of such operatic triumphs as Verdi's Simon Boccanegra and La forza del destino. Using their page delivery service, visitors can zoom in and out among the pages of each musical manuscript to their heart's desire. Of course, the site also includes the Harvard Song Book of 1922,which features such chestnuts as "Fair Harvard" and "Ten Thousand Men of Harvard".

293

EuroSCORE II e a importância de um modelo local, InsCor e o futuro SP-SCORE / EuroSCORE II and the importance of a local model, InsCor and the future SP-SCORE  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese Introdução: O modelo mais utilizado para predição de mortalidade em cirurgia cardíaca foi recentemente remodelado, mas dúvidas referentes à sua metodologia e desenvolvimento têm sido relatadas. Objetivo: O objetivo deste estudo foi avaliar o desempenho do EuroSCORE II na predição de mortalidade e [...] m pacientes submetidos a cirurgia de coronária e/ou valva na instituição. Métodos: Mil pacientes, operados consecutivamente de coronária e/ou valva, entre outubro de 2008 e julho de 2009, foram analisados. O desfecho de interesse foi mortalidade intra-hospitalar. A calibração foi realizada pela correlação entre mortalidade esperada e observada por meio do teste de Hosmer Lemeshow. A discriminação foi calculada pela área abaixo da curva ROC. O desempenho do EuroSCORE II foi comparado com os modelos EuroSCORE e InsCor (modelo local). Resultados: Na calibração, o teste de Hosmer Lemeshow foi inadequado para o EuroSCORE II (P=0,0003) e bom para os modelos EuroSCORE (P=0,593) e InsCor (P=0,184). No entanto, na discriminação, a área abaixo da curva ROC para o EuroSCORE II foi de 0,81 [IC 95% (0,76-0,85), P Abstract in english Introduction: The most widely used model for predicting mortality in cardiac surgery was recently remodeled, but the doubts regarding its methodology and development have been reported. Objective: The aim of this study was to assess the performance of the EuroSCORE II to predict mortality in pati [...] ents undergoing coronary artery bypass grafts or valve surgery at our institution. Methods: One thousand consecutive patients operated on coronary artery bypass grafts or valve surgery, between October 2008 and July 2009, were analyzed. The outcome of interest was in-hospital mortality. Calibration was performed by correlation between observed and expected mortality by Hosmer Lemeshow. Discrimination was calculated by the area under the ROC curve. The performance of the EuroSCORE II was compared with the EuroSCORE and InsCor (local model). Results: In calibration, the Hosmer Lemeshow test was inappropriate for the EuroSCORE II (P=0.0003) and good for the EuroSCORE (P=0.593) and InsCor (P=0.184). However, the discrimination, the area under the ROC curve for EuroSCORE II was 0.81 [95% CI (0.76 to 0.85), P

Luiz Augusto Ferreira, Lisboa; Omar Asdrubal Vilca, Mejia; Luiz Felipe Pinho, Moreira; Luís Alberto Oliveira, Dallan; Pablo Maria Alberto, Pomerantzeff; Luís Roberto Palma, Dallan; Maria Raquel B., Massoti; Fabio B., Jatene.

2014-03-01

294

SCRAM: a scoring and ranking system for persistent, bioaccumulative, and toxic substances for the North American Great Lakes. Part III. Acute and subchronic or chronic toxicity  

Energy Technology Data Exchange (ETDEWEB)

In part I of this series (Snyder et al., 1999a), the chemical scoring and ranking assessment model (SCRAM) was introduced. This system produces scores for chemicals based on their bioaccumulation potential, environmental persistence, and toxicity. In part II, scoring of the potential for a chemical to persist in the environment and bioaccumulate was described (Snyder et al., 1999b). In part III, scoring of chemical toxicity is discussed, including definitions and descriptions of effects that are scored, specific scoring instructions, the basis for the criteria and scores, and specific conditions or concerns regarding the types of data used for scoring. A score for each chemical screened is determined from available test data from acute or subchronic and chronic toxicity tests conducted on aquatic and terrestrial organisms. Subchronic and chronic human health effects, including carcinogenicity, are also considered. Part IV includes an evaluation of the performance of the scoring and ranking system. (orig.)

Snyder, E.M.; Snyder, S.A.; Giesy, J.P. [Dept. of Zoology, Michigan State Univ., National Food Safety and Toxicology Center and Inst. of Environmental Toxicology, East Lansing, MI (United States); Blonde, S.A.; Hurlburt, G.K.; Summer, C.L.; Mitchell, R.R.; Bush, D.M. [Surface Water Quality Div., Michigan Dept. of Environmental Quality, Lansing, MI (United States)

2000-07-01

295

Systemic Risk Score: A Suggestion  

OpenAIRE

We identify a potential bias in the methodology disclosed in July 2013 by the Basel Committee on Banking Supervision (BCBS) for identifying systemically important financial banks. Contrary to the original objective, the relative importance of the five categories of risk importance (size, cross-jurisdictional activity, interconnectedness, substitutability/financial institution infrastructure, and complexity) may not be equal and the resulting systemic risk scores are mechanically dominated by ...

Hurlin, Christophe; Pe?rignon, Christophe

2013-01-01

296

S-ID SAT Scores  

Science.gov (United States)

This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: Suppose that SAT mathematics scores for a particular year are approximately normally distributed with a mean of 510 and a standard deviation of 100. Wh...

297

Score regularization for peptide identification  

OpenAIRE

Abstract Background Peptide identification from tandem mass spectrometry (MS/MS) data is one of the most important problems in computational proteomics. This technique relies heavily on the accurate assessment of the quality of peptide-spectrum matches (PSMs). However, current MS technology and PSM scoring algorithm are far from perfect, leading to the generation of incorrect peptide-spectrum pairs. Thus, it is critical to develop new post-processing techniques that can distinguish true ident...

Yu Weichuan; Zhao Hongyu; He Zengyou

2011-01-01

298

The Bandim tuberculosis score : Reliability and comparison with the Karnofsky performance score  

DEFF Research Database (Denmark)

Background: This study was carried out in Guinea-Bissau's capital Bissau among inpatients and outpatients attending for tuberculosis (TB) treatment within the study area of the Bandim Health Project, a Health and Demographic Surveillance Site. Our aim was to assess the variability between 2 physicians in performing the Bandim tuberculosis score (TBscore), a clinical severity score for pulmonary TB (PTB), and to compare it to the Karnofsky performance score (KPS). Method: From December 2008 to July 2009 we assessed the TBscore and the KPS of 100 PTB patients at inclusion in the TB cohort and/or at 1 or more follow-up visits; 61 baseline and 130 follow-up double assessments were obtained. Results: The inter-observer variability of the TBscore (5 symptoms and 6 clinical findings) varied from slight to almost perfect agreement. For the TBscore, all 3 severity classes (SC I-III) were observed, while the KPS only yielded 2 of its 3 possible classes. The grading of PTB patients into severity classes showed moderate agreement for both the TBscore (?(w) = 0.52, 95% confidence interval 0.46-0.56) and the KPS (?(w) = 0.49, 95% confidence interval 0.33-0.65). The intra-class correlation coefficient (ICC) was larger for the TBscore than for the KPS (0.822 vs 0.632). Conclusions: The Bandim TBscore had an acceptable inter-observer variability, seemed to be more disease-related, and performed better than the KPS.

Rudolf, Frauke; Joaquim, Luis Carlos

2013-01-01

299

Cross-Cultural Adaptation of Developmental Criteria for Young Children: A Preliminary Psychometric Study  

Directory of Open Access Journals (Sweden)

Full Text Available Authentic assessment approach applies naturalistic observation method to gather and analyse data about children’s development that are socio-culturally appropriate to plan for individual teaching and learning needs. This article discusses the process of adapting an authentic developmental instrument for children of 3-6 years old. The instrument consists of 217 criteria of development for children between the ages of 36-72 months; grouped under six domains, which are fine motor, gross motor, adaptive, cognitive, socio-communication, and social. It is a criterion measurement tool, which was developed for the American context. This instrument needed to be adapted into the Malay socio-cultural context before it could be applied in local setting. The adaptation process involved directly translating the items; investigating the items/criteria’s score format; examining the items by a panel of experts; observing the real setting to investigate the score patterns and calculating observer agreement index. 103 children from the Malay ethnic group aged between 36-72 months, six field experts, and twelve observers were involved as participants. The researcher and an editor translated all the criteria for development; novice observers carried out a pilot study to test the suitability of score format; six children’s specialists examined the translated criteria; and lastly, the researcher observed activities in the preschool setting to score the criteria in naturalistic manner. The translated criteria, checklists; and developmental scores were analysed through visual and descriptive statistics. Content analyses showed that most of the developmental criteria were suitable to be applied in the research context. However, there are a few criteria considered as not appropriate and scores between observers indicated low agreement on how they interpreted the criteria.

Faridah Yunus

2014-12-01

300

Greek stroke score, Siriraj score and allen score in clinical diagnosis of intracerebral hemorrhage and infarct: Validation and comparison study  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: To compare Greek stroke score with available previous two stroke scores for the diagnosis of cerebral ischemia and hemorrhage in acute stroke patients, and validate the Greek stroke score. SETTING: A tertiary hospital in India. MATERIALS AND METHODS: In a prospective study acute stroke patients were evaluated with Greek stroke score, Allen score and Siriraj stroke score. Comparability (Kappa Statistics and validity (sensitivity, specificity, negative predictive value and positive predictive value of the Greek stroke score and previous scores were tested. RESULT: Out of the 91 patients enrolled in the study, 47 patients had cerebral infarction and 44 patients had hemorrhage by CT scan. Allen score was uncertain / equivocal in 39 patients, Siriraj Stroke score in 22 and Greek stroke score in 47 patients. Sensitivity, Specificity, positive predictive value, negative predictive value for Allen score were 0.5(95% CI:0.34,0.58, 0.94(95% CI:0.86,0.98, 0.81(95% CI:0.56,0.95, 0.78(95% CI: 0.71,0.81 for Siriraj score were 0.75(95% CI: 0.63,0.84, 0.81(95% CI: 0.71,0.89, 0.77(95% CI: 0.65,0.86, 0.78(95% CI 0.69,0.86 and for Greek Score were 0.42(95% CI: 0.23,0.53, 0.93(95% CI: 0.87,0.98, 0.71(95% CI:0.39,0.91, 0.81(95% CI:0.75,0.85 respectively. Greek stroke score was compared with previous scores using kappa statistics which revealed substantial strength of agreement between the Allen Score for certain results. CONCLUSION: The overall comparability of Greek stroke score and Allen score was better as compared to Greek stroke score and Siriraj stroke score. Greek Stroke score was more specific in diagnosing hemorrhage as compared to Siriraj score. However, all these stroke scores lack accuracy hence could not be applied safely to guide the physician in management of stroke.

Soman Aamod

2004-10-01

301

Genetic and environmental effects influencing Guernsey type classification scores.  

Science.gov (United States)

American Guernsey Cattle Club type classification scores from 1956 through 1977 were examined. Herd explained 7 to 15%, year 1 to 9%, and herd-year 9 to 23% of variation in type traits. Age was important for most traits, increasing variation explained beyond a herd-year model by 1 to 7%. Month of classification and classifier increased multiple correlation squared beyond the herd plus year model by .5% or less for all traits. Two-way interactions between age, month of classification, and classifier were small. Repeatabilities were 26 to 49%. Age-correction factors were developed. Heritabilities of .30 for final score, .23 for general appearance, .19 for dairy character, .30 for body capacity, and .19 for mammary system were estimated from 23,072 daughter-dam pairs. Other heritabilities ranged from .13 for suspensory ligament to .43 for stature. Genetic correlations with final score were 1.00 for general appearance, .78 for dairy character, .75 for body capacity, and .74 for mammary system and ranged from .65 to .80 for other subtraits. Phenotypic correlations with final score were .89 for general appearance, .63 for dairy character, .56 for body capacity, and .67 for mammary system and ranged from .40 to .64 for other subtraits. PMID:6833587

Norman, H D; Cassell, B G; Dawdy, M L

1983-01-01

302

Developing a magnetic resonance imaging scoring system for peripheral psoriatic arthritis.  

DEFF Research Database (Denmark)

We describe the first steps in developing an OMERACT magnetic resonance imaging (MRI) scoring system for peripheral psoriatic arthritis (PsA). A preexisting MRI dataset (finger joints) from 10 patients with PsA was scored by 4 readers for bone erosion, bone edema, synovitis, tendinopathy, and extracapsular features of inflammation (including enthesitis) according to specified criteria. Scoring reliability between readers was moderate to high for bone edema and erosion, but lower for soft tissue inflammation. Measures to improve reliability for future exercises will include reviewing definitions of pathological features and prior reader calibration. Udgivelsesdato: 2007-Apr

McQueen, Fiona; Lassere, Marissa

2007-01-01

303

Credit Scoring Model Hybridizing Artificial Intelligence with Logistic Regression  

Directory of Open Access Journals (Sweden)

Full Text Available Today the most commonly used techniques for credit scoring are artificial intelligence and statistics. In this paper, we started a new way to use these two kinds of models. Through logistic regression filters the variables with a high degree of correlation, artificial intelligence models reduce complexity and accelerate convergence, while these models hybridizing logistic regression have better explanations in statistically significance, thus improve the effect of artificial intelligence models. With experiments on German data set, we find an interesting phenomenon defined as ‘Dimensional interference’ with support vector machine and from cross validation it can be seen that the new method gives a lot of help with credit scoring.

Han Lu

2013-01-01

304

Reliability and Validity of the Cross-Culturally Adapted German Oxford Hip Score  

OpenAIRE

There is currently no German version of the Oxford hip score. Therefore we sought to cross-culturally adapt and validate the Oxford hip score for use with German-speaking patients (OHS-D) with osteoarthritis of the hip using a forward-backward translation procedure. We then assessed the new score in 105 consecutive patients (mean age, 63.4 years; 48 women) undergoing THA. We specifically determined: the number of fully completed questionnaires, reliability, concurrent validity by correlation...

Naal, Florian D.; Sieverding, Marc; Impellizzeri, Franco M.; Von Knoch, Fabian; Mannion, Anne F.; Leunig, Michael

2008-01-01

305

Practical way to assess metabolic syndrome using a continuous score obtained from principal components analysis  

OpenAIRE

AIMS/HYPOTHESIS: We devised a practical continuous score to assess the metabolic syndrome, and assessed whether this syndrome score predicts incident diabetes and cardiovascular disease. SUBJECTS AND METHODS: Among 5,024 participants of the Data from an Epidemiological Study on the Insulin Resistance Syndrome (D.E.S.I.R.) cohort, we defined a metabolic syndrome score by the first principal component (PC1), using only the correlations between continuous metabolic syndrome measures (glucose, wa...

Hillier, Teresa; Rousseau, A.; Lange, Ce?line; Le?pinay, P.; Cailleau, Martine; Novak, M.; Calliez, Etienne; Ducimetie?re, Pierre; Balkau, Beverley

2006-01-01

306

Computer-Assisted Portfolio Scoring: Can Technology Enhance the Process of Scoring Portfolios?  

Science.gov (United States)

The need for effective ways of monitoring the quality of scoring of portfolios resulted in the development of a software package that provides scoring leaders with updated information on their assessors' scoring quality. Assessors with computers enter data as they score, and this information is analyzed and reported to scoring leaders. The…

Solano-Flores, Guillermo; Raymond, Bruce; Schneider, Steven A.

307

Ability to learn inhaler technique in relation to cognitive scores and tests of praxis in old age.  

Science.gov (United States)

Clinical observations have shown that some older patients are unable to learn to use a metered dose inhaler (MDI) despite having a normal abbreviated mental test (AMT) score, possibly because of dyspraxia or unrecognised cognitive impairment. Thirty inhaler-naive inpatients (age 76-94) with an AMT score of 8-10 (normal) were studied. Standard MDI training was given and the level of competence reached was scored (inhalation score). A separate observer performed the minimental test (MMT), Barthel index, geriatric depression score (GDS), ideational dyspraxia test (IDT), and ideomotor dyspraxia test (IMD). No correlative or threshold relationship was found between inhalation score and Barthel index, GDS, or IDT. However, a significant correlation was found between inhalation score and IMD (r = 0.45, p = 0.039) and MMT (r = 0.48, p = 0.032) and threshold effects emerged in that no subject with a MMT score of less than 23/30 had an inhalation score of 5/10 or more (adequate technique requires 6/10 or more), and all 17/18 with an inhalation score of 6/10 or more had an IMD of 14/20 or more. The three patients with a MMT >22 and inhalation score <6 had abnormal IMD scores. Inability to learn an adequate inhaler technique in subjects with a normal AMT score appears to be due to unrecognised cognitive impairment or dyspraxia. The MMT is probably a more useful screening test than the AMT score in this context. PMID:11796871

Allen, S C; Ragab, S

2002-01-01

308

Relation of computer esthesiometry and symptom scores in diagnostics of diabetic polyneuropathy  

Directory of Open Access Journals (Sweden)

Full Text Available The purpose of our research was to define the most important diagnostic criteria in early diagnosis of distal polyneuropathy in diabetic patients. Participants included 175 patients with diabetes mellitus types 1 and 2 (male-to-female ratio 89:86, mean (±SD age 42.02±15.27 years with risk diabetic polyneuropathy. Research included Total Symptom Score, Neuropathy Symptom Score, Neuropathy Impairment Score, Visual Analog Score, standard somatic and neurologic status were evaluated in all patients at the beginning of the study. Vibration sensitivity investigated on lower extremities by means of the computer diagnostic equipment " Vibrotester - MBN" (Moscow, Russian Federation in a wide range of vibration frequencies (8, 16, 32, 63, 125, 250, 500 Hz. Statistical data processing was using Statistica v.8.0 (StatSoft, USA. Diabetic polyneuropathy was diagnosed in 166 (94.7% patients with diabetes mellitus. The most sensitive methods were computer esthesiometry method, Neuropathy Impairment Score, and their combination.

Olga Darsavelidze

2010-12-01

309

Correlation between HRCT and pulmonary functional tests in cystic fibrosis  

International Nuclear Information System (INIS)

Purpose. To compare the HRCT score by Oikonottlou and air trapping in expiratory scans with pulmonary functional tests and evaluate which radiological criteria are more useful to predict clinical impairment. Materials and methods. From January to September 2003, pulmonary HRCT study was performed in 37 patients (23 males), aged between 7 and 41 years, with cystic fibrosis. In the same day of CT examination they also received a complete functional evaluation. HRCT studies were evaluated by three radiologists blinded to the clinical data and were correlated with the lung function tests. Results. We obtained a high correlation (p=0.01) for two of the HRCT signs: extent of mucus plugging and mosaic perfusion pattern and all function tests. Discussion. Previous studies have demonstrated good correlation between lung function tests, in particular with FEV1 and HRCT signs. Our study differed from previous ones in that we analysed the correlation between lung function tests and with both single and combined CT criteria. Conclusion. Our results suggest that a simplified HRCT store could be useful to evaluate patients with cystic fibrosis

310

Evaluation of association between obstructive sleep apnea and coronary risk scores predicted by tomographic coronary calcium scoring in asymptomatic patients  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: This cross-sectional observational study is designed to evaluate direct effects of obstructive sleep apnea syndrome (OSA on presence and extent of coronary atherosclerosis by using tomographic coronary calcification scoring on a population asymptomatic for coronary artery disease.Methods: Ninety-seven consecutive patients (49.17±0.86 years who were evaluated with sleep study for the suspicion of obstructive sleep apnea syndrome underwent tomographic coronary calcium scoring test. Cardiovascular risk factors, current medications and sleep study recordings of all patients were recorded. Patients were classified into 4 groups according to the apnea-hypopnea index (AHI. Linear and logistic regression analyses were used for assessment of association between variables.Results: Coronary risk scores of patients, assessed by tomographic coronary calcium scoring, were observed to increase linearly from simple snoring group to severe OSA groups (p=0.046. When patients were classified according to their gender, AHI and parameters reflecting severity of OSA-related hypoxia were found to correlate significantly with coronary risk scores of women but not with scores of men. Linear regression analysis revealed age as the only independent associated variable with cardiovascular risk scores assessed by tomographic coronary calcification scoring (Beta coefficient: 0.27, 95% CI 0.007-0.087, p=0.018. Binary logistic regression analysis also revealed age as the only variable which independently predicted the presence of coronary calcification (OR:1.11, 95% CI 1.039-1.188, p=0.002.Conclusion: These results suggest that presence of OSA may contribute to coronary artery disease risk of patients in association with its severity; however, association between OSA and subclinical atherosclerosis seems to be primarily dependent on age.

Alper Kepez

2011-08-01

311

Admissions Criteria and Diversity in Graduate School  

OpenAIRE

In this work, I point out the negative implications for diversity in graduate school resulting from the use of cutoff scores on the GRE in the admissions process. In light of the data presented, as well as a swelling body of evidence suggesting no long term correlation with research success, I pose several challenges to the community related to the continued use of the GRE.

Miller, Casey W.

2013-01-01

312

The Association between SAT Prompt Characteristics, Response Features, and Essay Scores  

Science.gov (United States)

This study investigated the relationship of prompt characteristics and response features with essay scores on the SAT Reasoning Test. A sample of essays was coded on a variety of features regarding their length and content. Analyses included descriptive statistics and computation of effect sizes, correlations between essay features and scores, and…

Kobrin, Jennifer L.; Deng, Hui; Shaw, Emily J.

2011-01-01

313

Automatic scoring of the severity of psoriasis scaling  

DEFF Research Database (Denmark)

In this work, a combined statistical and image analysis method to automatically evaluate the severity of scaling in psoriasis lesions is proposed. The method separates the different regions of the disease in the image and scores the degree of scaling based on the properties of these areas. The proposed method provides a solution to the lack of suitable methods to assess the lesion and to evaluate changes during the treatment. An experiment over a collection of psoriasis images is conducted to test the performance of the method. Results show that the obtained scores are highly correlated with scores made by doctors. This and the fact that the obtained measures are continuous indicate the proposed method is a suitable tool to evaluate the lesion and to track the evolution of dermatological diseases.

Gomez, David Delgado; ErsbØll, Bjarne Kjær

2004-01-01

314

A pilot study to evaluate the effects of Cerebrolysin on cognition and qEEG in vascular dementia: cognitive improvement correlates with qEEG acceleration.  

Science.gov (United States)

The effects of the neurotrophic compound Cerebrolysin (Cere) on cognitive performance, evaluated with the ADAS-cog, and on qEEG activity were investigated in forty one patients with mild to moderate severe probable vascular dementia (VaD) according to NINDS-AIREN criteria, included in a placebo-controlled pilot study. Patients received i.v. infusions of Cere (10 or 30 ml) or placebo (normal saline) 5 days/week for 4 weeks. Mean score of change from baseline in the ADAS-cog and percent change from baseline in slow to fast EEG power ratio (PR) scores were the two primary endpoints. Correlations between cognition and qEEG were also evaluated for both baseline scores and for scores of change from baseline in ADAS-cog and in qEEG parameters, including EEG power ratio (PR) as an index of EEG slowing. Baseline ADAS-cog scores showed significant positive correlations with delta power, theta power and PR scores, and correlated negatively with alpha activity. These correlations indicating that an increased EEG slowing is associated with a worst cognitive performance in VaD patients. Cere treatment improved cognitive performance significantly at the 10 ml dose and reduced EEG slowing with both 10 and 30 ml dosages. A significant positive correlation between PR and ADAS-cog scores of change from baseline was observed in Cere-treated patients. According to results of this pilot study, it is concluded that Cere improves cognitive performance and reduces EEG slowing in patients with VaD, and that there is a positive relationship between changes in cognition and qEEG activity induced by Cere. The conduction of further regular clinical trials is required to confirm the potential utility of Cere in the treatment of VaD suggested by the present results. PMID:18048059

Muresanu, Dafin F; Alvarez, X Anton; Moessler, Herbert; Buia, Manuel; Stan, Adina; Pintea, Daniela; Moldovan, Florina; Popescu, Bogdan O

2008-04-15

315

Undervoltage Breakdown Threshold Criteria  

Science.gov (United States)

Undervoltage breakdown, the process by which a pulse of electrons induces a discharge gap to break down when it is near but has not achieved its self-breakdown conditions, is discussed. Specifically, threshold criteria that determine the number of electrons required to induce breakdown both to glow and arc discharges are presented. Numerical and theoretical predictions of these criteria are compared with experimental results. Undervoltage breakdown is the phenomenon that governs discharge initiation in gas-fed pulsed plasma thrusters, the device of primary interest to the authors. The phenomenon is also relevant to several other applications including psuedospark switches and other command-triggering devices as well as gas avalanche particle detectors.

Cooley, James; Choueiri, Edgar

2006-10-01

316

Correlação entre Inventário de Depressão de Beck e cortisol urinário em diabéticos tipo 2 Correlación entre el inventario de Depresión de Beck y el cortisol urinario en diabeticos tipo 2 Correlation between urine cortisol and scores on the Beck Depression inventory in patients with type 2 diabetes  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVO: Verificar a correlação entre o cortisol urinário e o Inventário de Depressão de Beck em diabéticos do tipo 2. MÉTODOS: O cortisol urinário foi avaliado em uma amostra composta por 40 pacientes da Liga de Controle de Diabetes da Disciplina de Endocrinologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo e para a avaliação dos sintomas de depressão foi aplicado o Inventário de Depressão de Beck. RESULTADOS: Alta confiabilidade para o Inventário de Depressão de Beck(Alfa de Cronbach=0,920e correlação significativa foi observada entre cortisol urinário e Inventário de Depressão de Beck(Spearman,r=0.523,pOBJETIVO: Verificar la correlación entre el cortisol urinario y el Inventario de Depresión de Beck en diabéticos del tipo 2. MÉTODOS: El cortisol urinario fue evaluado en una muestra compuesta por 40 pacientes de la Liga de Control de Diabetes de la Disciplina de Endocrinología del Hospital de las Clínicas de la Facultad de Medicina de la Universidad de Sao Paulo y para la evaluación de los síntomas de depresión fue aplicado el Inventario de Depresión de Beck. RESULTADOS: Alta confiabilidad para el Inventario de Depresión de Beck(Alfa de Cronbach=0,920 y correlación significativa observada entre el cortisol urinario e Inventario de Depresión de Beck (Spearman,r=0.523,pOBJECTIVE: To determine the relationship between urinary cortisol and scores on the Beck Depression Inventory in type 2 diabetics. METHODS: The sample consisted of 40 patients with type 2 diabetes from the diabetes control league of the discipline of endocrinology of the HCFM-USP. Measures consisted of urinary cortisol and depression symptoms using the Beck Depression Inventory. RESULTS: The Beck Depression Inventory had a Cronbach's alpha of 0.92. There was a statistically significant correlation between urinary cortisol and scores on the Beck Depression Inventory (Spearman r = 0.52, p < .001. CONCLUSIONS: The Beck Depression Inventory was found to be a reliable indicator of depressive symptoms in patients with type 2 diabetes. Urine cortisol is associated with the presence of depressive symptoms.

Alexandra Bulgarelli do Nascimento

2009-01-01

317

Robustness - acceptance criteria  

DEFF Research Database (Denmark)

This factsheet describes the general framework on the bases of which acceptance criteria for requirements on the robustness of structures can be set. Such framework is based on the more general concept of risk-based assessment of engineering systems. The present factsheet is to be seen in conjunction with the one on the theoretical framework for robustness (Sørensen et al. 2009). In the present factsheet, the focus is on normative implications.

Rizzuto, Enrico; SØrensen, John Dalsgaard

2010-01-01

318

An Inmate Classification System Based on PCL: SV Factor Scores in a Sample of Prison Inmates  

Science.gov (United States)

Psychopaths represent a significant management challenge in a prison population. A sample of ninety-five male inmates from three medium security prisons was tested using the Hare Psychopathy Checklist: Screening Version (PCL:SV). Using traditional criteria, 22% of the inmates were classified as psychopaths. Scores on the two factor dimensions of…

Wogan, Michael; Mackenzie, Marci

2007-01-01

319

Validation of Geriatric Depression Scale--5 Scores among Sedentary Older Adults  

Science.gov (United States)

This study examined the validity of Geriatric Depression Scale--5 (GDS-5) scores among older sedentary adults based on its structural properties and relationship with external criteria. Participants from two samples (Ns = 185 and 93; M ages = 66 and 67 years) completed baseline assessments as part of randomized controlled exercise trials.…

Marquez, David X.; McAuley, Edward; Motl, Robert W.; Elavsky, Steriani; Konopack, James F.; Jerome, Gerald J.; Kramer, Arthur F.

2006-01-01

320

Score lists in multipartite hypertournaments  

CERN Document Server

Given non-negative integers $n_{i}$ and $\\alpha_{i}$ with $0 \\leq \\alpha_{i} \\leq n_i$ $(i=1,2,...,k)$, an $[\\alpha_{1},\\alpha_{2},...,\\alpha_{k}]$-$k$-partite hypertournament on $\\sum_{1}^{k}n_{i}$ vertices is a $(k+1)$-tuple $(U_{1},U_{2},...,U_{k},E)$, where $U_{i}$ are $k$ vertex sets with $|U_{i}|=n_{i}$, and $E$ is a set of $\\sum_{1}^{k}\\alpha_{i}$-tuples of vertices, called arcs, with exactly $\\alpha_{i}$ vertices from $U_{i}$, such that any $\\sum_{1}^{k}\\alpha_{i}$ subset $\\cup_{1}^{k}U_{i}^{\\prime}$ of $\\cup_{1}^{k}U_{i}$, $E$ contains exactly one of the $(\\sum_{1}^{k} \\alpha_{i})!$ $\\sum_{1}^{k}\\alpha_{i}$-tuples whose entries belong to $\\cup_{1}^{k}U_{i}^{\\prime}$. We obtain necessary and sufficient conditions for $k$ lists of non-negative integers in non-decreasing order to be the losing score lists and to be the score lists of some $k$-partite hypertournament.

Pirzada, Shariefuddin; Iványi, Antal

2010-01-01

321

Does Work Environment Affect Faculty Health Scores?  

Directory of Open Access Journals (Sweden)

Full Text Available This study investigates the relationship between self-reported health scores with work environment and various components of a women faculty score at a Research 1 University in the Midwest USA. The study examines the differences between male and female faculty responses in the various components making up the women faculty score and also gender differences in self-reported health scores and work environment scores. Differences between STEM and Non-STEM faculty are examined. A significant positive relationship is found between self-reported health scores and work environment controlling for gender. The study finds that the overall university work environment has a stronger relationship to faculty health than adequate gender ratio, women climate, and women leadership, even for women faculty. No significant differences in responses are found between STEM and Non-STEM faculty for women climate, women leadership, health scores, and work environment scores. Significant differences are found only in adequate gender ratio.

Rhonda C. Magel

2013-09-01

322

How Does NAEP Ensure Consistency in Scoring?  

Science.gov (United States)

Discusses techniques used to ensure consistent scoring of written student responses in such subjects as reading, mathematics, writing, science, geography, U.S. history, and civics. Describes selecting scorers and image scoring and monitoring. (SLD)

White, Sheida; Smith, Connie; Vanneman, Alan

2000-01-01

323

A novel scoring system for evaluation of results of autologous transplantation methods in vitiligo  

Directory of Open Access Journals (Sweden)

Full Text Available Autologous transplantation of melanocyte/melanocytes bearing epidermis for vitiligo can be done by mini-punch grafting (MPG, suction blister epidermal grafting (SBEG, thin split -thickness skin grafting (TSTG, transplantation of basal cell layer enriched suspension and cultured epithelial/melanocyte transplantation. To date no comparative study of these transplantation procedures has been published. Comparison of different studies carried out at different centers may be difficult in the absence of uniform evaluation criteria. In most of the published studies, the results were evaluated in terms of extent of pigmentation. Complictions and color match were evaluated separately. This approach, however, may not give a fair idea about the results. We have developed a scoring system with holistic approach considering the extent of pigmentation, color match and the complications of both the donor and the recipient areas, all taken together. In the scoring system, the score for individual criteria was multiplied with a factor, the value of which was decided on the basis of relative importance of each criteria. The use of this scoring system is exemplified in twelve patients who underwent TSTG, SBEG and MPG. In the scoring system the results were judged as excellent and fair in 3 patients each, as good in 4 patients and as poor in 2 patients.

Gupta Somesh

2002-01-01

324

Proposal of a CT scoring system of the paranasal sinuses in diagnosing cystic fibrosis  

International Nuclear Information System (INIS)

The purpose of this study was to develop a paranasal sinus CT scoring system that could be used as a diagnostic tool to discriminate cystic fibrosis (CF) patients from control patients examined for sinonasal disease. The model should include as few and easily applicable criteria as possible, supported by statistical analyses and clinical judgement. We used data from 116 CF and 136 control patients. The CF patients were grouped according to the number of confirmed CF mutations: genetically verified (CF-2), or based on sweat testing and clinical findings alone (CF-1, CF-0). Nine paranasal sinus CT criteria, including development, pneumatisation variants and inflammatory patterns, were evaluated. The final model included three criteria: (a) frontal and (b) sphenoid sinus development, and (c) absence of three pneumatisation variants. This model discriminated CF-2 from controls with overlap of summed scores in only 8 of 206 patients. When this model was applied in the CF-1 and CF-0 groups, two populations seemed to exist. A larger group with summed scores overlapping that of the CF-2 group and a smaller group with summed scores overlapping that of the control group. We conclude that this CT scoring system may support, as well as exclude, a CF diagnosis in cases of diagnostic uncertainty. (orig.)

325

Modified PADSS (Post Anaesthetic Discharge Scoring System) for monitoring outpatients discharge.  

Science.gov (United States)

The decision to discharge a patient undergoing day surgery is a major step in the hospitalization pathway, because it must be achieved without compromising the quality of care, thus ensuring the same assistance and wellbeing as for a long-term stay. Therefore, the use of an objective assessment for the management of a fair and safe discharge is essential. The authors propose the Post Anaesthetic Discharge Scoring System (PADSS), which considers six criteria: vital signs, ambulation, nausea/vomiting, pain, bleeding and voiding. Each criterion is given a score ranging from 0 to 2. Only patients who achieve a score of 9 or more are considered ready for discharge. Furthermore, PADSS has been modified to ensure a higher level of safety, thus the "vital signs" criteria must never score lower than 2, and none of the other five criteria must ever be equal to 0, even if the total score reaches 9. The effectiveness of PADSS was analyzed on 2432 patients, by recording the incidence of postoperative complications and the readmission to hospital. So far PADDS has proved to be an efficient system that guarantees safe discharge. PMID:23165318

Palumbo, Piergaspare; Tellan, Guglielmo; Perotti, Bruno; Pacilè, Maria Antonietta; Vietri, Francesco; Illuminati, Giulio

2013-01-01

326

Comparison of Selvester QRS score with magnetic resonance imaging measured infarct size in patients with ST elevation myocardial infarction  

DEFF Research Database (Denmark)

Recent studies have shown that the Selvester QRS score is significantly correlated with delayed enhancement-magnetic resonance imaging (DE-MRI) measured myocardial infarct (MI) size in reperfused ST elevation MI (STEMI). This study further tests the hypothesis that Selvester QRS score correlates well with MI size determined by DE-MRI in reperfused STEMI.

Carlsen, Esben A; Bang, Lia E

2012-01-01

327

Evaluation of haemophilic arthropathy - a comparison of MRI and Pettersson score  

International Nuclear Information System (INIS)

Purpose: In order to compare score values, joint alterations in haemophilic patients on early and late prophylaxis were assessed and evaluated by X-ray radiography and magnetic resonance imaging (MRI) in a prospective study. Patients and methods: 24 joints (10 knees and 14 ankles) of 15 haemophilic patiens, with at least one manifestation of bleeding (proven by sonographic assessment) were investigated. Radiological and MRI investigations were done after complete resorption of bleeding. For radiological evaluation a Petterson score (max. 13 points), and for MRI evaluation a modified MRI score (max. 13 points) according to Nuss et al. were used. Results: Good correlation could be demonstrated between the number of joint bleedings and the degree of arthropathy. 16 joints with maximal 2 bleedings had no alteration on both MRI and radiological assessment. Joints with 3 bleedings had Pettersson score from 0 - 3 points and MRI scores of 2 points. Joints with ?4 bleedings had a radiological score between 7 and 12 points, MRI scores ranged from 3 to 8 points. Conclusion: Increasing severity of haemophilic arthropathy could be demonstrated initially by the MRI score and later by the Pettersson score depending on the number of bleedings. The MRI score describes initial joints alterations more precisely and earlier than the Pettersson score, allowing a discerning estimation of the degree and a follow-up of haemophilic arthropathy. (orig.))

328

Total Mini-Mental State Examination score and regional cerebral blood flow using Z score imaging and automated ROI analysis software in subjects with memory impairment  

International Nuclear Information System (INIS)

The Mini-Mental State Examination (MMSE) is considered a useful supplementary method to diagnose dementia and evaluate the severity of cognitive disturbance. However, the region of the cerebrum that correlates with the MMSE score is not clear. Recently, a new method was developed to analyze regional cerebral blood flow (rCBF) using a Z score imaging system (eZIS). This system shows changes of rCBF when compared with a normal database. In addition, a three-dimensional stereotaxic region of interest (ROI) template (3DSRT), fully automated ROI analysis software was developed. The objective of this study was to investigate the correlation between rCBF changes and total MMSE score using these new methods. The association between total MMSE score and rCBF changes was investigated in 24 patients (mean age±standard deviation (SD) 71.5±9.2 years; 6 men and 18 women) with memory impairment using eZIS and 3DSRT. Step-wise multiple regression analysis was used for multivariate analysis, with the total MMSE score as the dependent variable and rCBF change in 24 areas as the independent variable. Total MMSE score was significantly correlated only with the reduction of left hippocampal perfusion but not with right (P<0.01). Total MMSE score is an important indicator of left hippocampal function. (author)

329

Coronary artery calcium scoring in myocardial infarction  

International Nuclear Information System (INIS)

Background. The aim of this study was to evaluate coronary artery calcium scoring and the assessment of the risk factors in patients with myocardial infarction (MI). Methods. During the period of three years, 27 patients with MI were analyzed. The average age of patients was 66.1 years (46 to 81). Coronary arteries calcium was evaluated by multi row detector computed tomography (MTDC) Somatom Volume Zoom Siemens, and, retrospectively by ECG gating data acquisition. Semi automated calcium quantification to calculate Agatston calcium score (CS) was performed with 4 x 2.5 mm collimation, using 130 ml of contrast medium, injected with an automatic injector, with the flow rate of 4 ml/sec. The delay time was determined empirically. At the same time several risk factors were evaluated. Results. Out of 27 patients with MI, 3 (11.1%) patients had low CS (10- 100), 5 (18.5%) moderate CS (101- 499), and 19 (70.4%) patients high CS (>500). Of risk factors, smoking was confirmed in 17 (63.0%), high blood pressure (HTA) in 10 (57.0%), diabetes mellitus in 7 (25.9%), positive family history in 5 (18.5%), pathological lipids in 5 (18.5%), alcohol abuse in 4 (1.8%) patients. Six (22.2%) patients had symptoms of angina pectoris. Conclusions. The research showed high correlation of MI and high CS (>500). Smoking, HTA, diabetes mellitus, positive family history and hypercholesterolemia are significant risk factors. Symptoms are relatively poor in large number of pa are relatively poor in large number of patients. (author)

330

Relationship between motor performance and physical fitness score in 7- to 8-year-old children. DOI: 10.5007/1980-0037.2011v13n2p94  

Directory of Open Access Journals (Sweden)

Full Text Available There are many tests for the evaluation of motor performance or physical fitness that take into account different criteria such as movement forms and patterns, time, distance, and repetitions of each task for the analysis of performance. The aim of this study was to investigate the relationship between motor performance and physical fitness scores in children. Fifty children of both genders aged 7 to 8 years (25 boys and 25 girls participated in this study. The Test of Gross Motor Development – Second Edition (TGMD-2 was used for the evaluation of motor performance. Physical fitness was assessed by three specific tests proposed by the American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD. The results showed statistical significance and weak correlations among some skills such as run, horizontal jump, hop, leap, underhand roll, and medicine ball throw. The equivalent use of both tests may not be adequate since each test has its own peculiarities in terms of assessment criteria.

Patrik Felipe Nazario

2011-03-01

331

Documentation of radiation-induced oral mucositis. Scoring Systems  

International Nuclear Information System (INIS)

Background: Radiation therapy of tumors in the head and neck region is frequently associated with severe side effects in the oral mucosa which often necessitate interruption of the prescribed treatment protocol. In order to compare therapeutic strategies and, more important, in order to perform multicenter studies, generally accepted scoring systems have to be applied for uniform documentation of the oral mucosal response. Methods: Different scoring protocols are found in the literature. The scoring protocols most widely accepted are the CTC classification and the RTOG/EORTC classification. These are compared with more detailed systems. Results: In the CTC classification, grading of stomatitis is included in the responses of the gastrointestinal tract and emphasizes dietary effects. For effects of radiation alone or of radiochemotherapy, the RTOG/EORTC system, focusing on therapeutic interventions, has been established. However, there are only minor differences in the grading of mucositis between these 2 protocols. Based on the RTOG/EORTC classification, Maciejewski et al. introduced a classification system with inclusion of the area affected, but also changed the sensitivity of the scores. The latter may be confusing if the source of the system used is not cited in a report. An alternative system was proposed by Dische, which in addition to objective morphologic criteria also includes the symptoms induced by the mucosal response, and hence includes some subjective asnse, and hence includes some subjective aspects reported by the patient. Conclusions: For routine documentation of acute radiation side effects in the oral cavity, the German version of the RTOG/EORTC classification can be recommended. In studies with particular interest in oral mucositis, a more sensitive scoring system may be applied. In any publication concerning mucositis, a table or a detailed description of the system used should be included. (orig.)

332

Cumulative t-link threshold models for the genetic analysis of calving ease scores  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract In this study, a hierarchical threshold mixed model based on a cumulative t-link specification for the analysis of ordinal data or more, specifically, calving ease scores, was developed. The validation of this model and the Markov chain Monte Carlo (MCMC algorithm was carried out on simulated data from normally and t4 (i.e. a t-distribution with four degrees of freedom distributed populations using the deviance information criterion (DIC and a pseudo Bayes factor (PBF measure to validate recently proposed model choice criteria. The simulation study indicated that although inference on the degrees of freedom parameter is possible, MCMC mixing was problematic. Nevertheless, the DIC and PBF were validated to be satisfactory measures of model fit to data. A sire and maternal grandsire cumulative t-link model was applied to a calving ease dataset from 8847 Italian Piemontese first parity dams. The cumulative t-link model was shown to lead to posterior means of direct and maternal heritabilities (0.40 ± 0.06, 0.11 ± 0.04 and a direct maternal genetic correlation (-0.58 ± 0.15 that were not different from the corresponding posterior means of the heritabilities (0.42 ± 0.07, 0.14 ± 0.04 and the genetic correlation (-0.55 ± 0.14 inferred under the conventional cumulative probit link threshold model. Furthermore, the correlation (> 0.99 between posterior means of sire progeny merit from the two models suggested no meaningful rerankings. Nevertheless, the cumulative t-link model was decisively chosen as the better fitting model for this calving ease data using DIC and PBF.

Tempelman Robert J

2003-09-01

333

Sustainable Criteria for Environmental Technology  

OpenAIRE

The demand for sustainable criteria for environmental technology has over the past few years increaseddue to competition amongst companies in the business due to legal demands. Using criteria for environmentaltechnology is a way for companies to show buyers that their product is a long term investment. Byimplementing sustainable criteria for environmental technology, companies can be sure they are buying andusing the best available technology adjusted to their economy. Sustainable criteria fo...

Kjellberg, Kristin

2004-01-01

334

Prognóstico dos casos de pancreatite aguda pelo escore de PANC 3 / Prognosis of acute pancreatitis by PANC 3 score  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese RACIONAL: A pancreatite aguda é doença de grande importância na prática clínica, definida como inflamação do pâncreas podendo levar ao envolvimento de tecidos locais ou acometimento de outros órgãos de forma sistêmica, necessitando nesses casos de cuidados em terapia intensiva. OBJETIVO: Analisar o [...] sistema simplificado de estratificação de PANC 3, correlacionando-o com o escore de Ranson para definição prognóstica de casos de pancreatite aguda. MÉTODO: Foi realizado um estudo observacional, prospectivo em que foram avaliados 65 pacientes que foram diagnosticados com quadro de pancreatite aguda. RESULTADOS: Obteve para o PANC 3 sensibilidade de 31,25%; especificidade de 100%; valor preditivo positivo de 100%; valor preditivo negativo de 81,66% e acurácia de 83,07%. CONCLUSÕES: Os critérios de PANC 3 têm sua validade na definição de gravidade e prognóstico da pancreatite aguda, não como método substituto, mas como método a ser associado aos critérios de Ranson, principalmente pela sua alta acurácia, valor preditivo positivo e especificidade. Abstract in english BACKGROUND: Acute pancreatitis is a disease of great importance in clinical practice, defined as an inflammatory process of the pancreas that may involve local tissues or affect other organs in a systemic manner, requiring, in such cases, an intensive care. AIM: To analyze the simplified stratificat [...] ion system of the PANC 3 score, correlating it with the Ranson score, for the prognostic definition of cases of acute pancreatitis. METHOD: Was conducted a prospective, observational study in which were evaluated 65 patients who were diagnosed with acute pancreatitis. RESULTS: PANC 3 showed sensitivity, 31.25%; specificity,100%; positive predictive value, 100%; negative predictive value, 81.66% and accuracy, 83.07%. CONCLUSIONS: The PANC 3 criteria are applicable to define the severity and the prognosis of acute pancreatitis, and are not a substitute method, but rather a method to be associated with the Ranson criteria, mainly due to its high accuracy, positive predictive value and specificity.

James Ken, Fukuda; Orli, Franzon; Fernando de Oliveira, Resende-Filho; Nicolau Fernandes, Kruel; Thiago Alessandro, Ferri.

2013-06-01

335

SCORE History / Social Science Resources  

Science.gov (United States)

SCORE, a cooperative project of the California County Superintendent's Educational Services Association, has made K-12 teacher and student resources in four major subject areas available at sites in Humboldt County (Science), San Diego County (Language Arts), Kings County (Mathematics), and San Bernardino and Butte Counties (Social Studies). While each site has its own personality and delivery style, they all make an attempt to break out teacher and/or student resources by grade level. In some cases (Science, Social Studies) this is done through a search interface. In others (Language Arts, Mathematics) it is done via a browsable interface. It is this categorization, plus the fact that resources are selected, evaluated, and annotated by teachers, that is the both the power and unifying theme of the sites. Depending on the site, assessment and teacher development sections may also be available.

336

Clinical evaluation of a new set of image quality criteria for mammography  

International Nuclear Information System (INIS)

The European Commission (EC) quality criteria for screen-film mammography are used as a tool to asses image quality. A new set of criteria was developed and initially tested in a previous study. In the present study, these criteria are further evaluated using screen-film mammograms that have been digitised, manipulated to simulated different image quality level and reprinted on film. Expert radiologists have evaluated these manipulated to simulate different image quality levels and reprinted on film. Expert radiologists have evaluated these manipulated images using both the original (EC) and the new criteria. A comparison of three different simulated dose levels that the new criteria yield a larger separation of image criteria scores than the old ones. These results indicated that the new set of image quality criteria has a higher discriminative power than the old set and thus seems to be more suitable for evaluation of image quality in mammography. (authors)

337

Credit Scoring Model Hybridizing Artificial Intelligence with Logistic Regression  

OpenAIRE

Today the most commonly used techniques for credit scoring are artificial intelligence and statistics. In this paper, we started a new way to use these two kinds of models. Through logistic regression filters the variables with a high degree of correlation, artificial intelligence models reduce complexity and accelerate convergence, while these models hybridizing logistic regression have better explanations in statistically significance, thus improve the effect of artificial intelligence mode...

Han Lu; Han Liyan; Zhao Hongwei

2013-01-01

338

Score Function of Distribution and Heavy-tails.  

Czech Academy of Sciences Publication Activity Database

Geneva : Centre international de conferences, 2014 - (Gilli, M.; Nieto-Reyes, A.; González-Rodríguez, G.), s. 657-664 ISBN 978-2-8399-1347-8. [COMPSTAT 2014. International Conference on Computational Statistics /21./. Geneva (CH), 19.08.2014-22.08.2014] R&D Projects: GA MŠk(CZ) LG12020 Institutional support: RVO:67985807 Keywords : score function * point estimation * correlation * heavy-tailed distributions Subject RIV: BB - Applied Statistics, Operational Research

Fabián, Zden?k

339

Criteria for software modularization  

Science.gov (United States)

A central issue in programming practice involves determining the appropriate size and information content of a software module. This study attempted to determine the effectiveness of two widely used criteria for software modularization, strength and size, in reducing fault rate and development cost. Data from 453 FORTRAN modules developed by professional programmers were analyzed. The results indicated that module strength is a good criterion with respect to fault rate, whereas arbitrary module size limitations inhibit programmer productivity. This analysis is a first step toward defining empirically based standards for software modularization.

Card, David N.; Page, Gerald T.; Mcgarry, Frank E.

1985-01-01

340

Web site Evaluation Criteria  

Directory of Open Access Journals (Sweden)

Full Text Available The ever-increasing evolution of the Internet and the growing number of the resources accessible through this medium, has turned the issue of resource evaluation of the internet-based information into a controversial and cogent issue. By nature, the internet milieu is uncontrollable. It concomitantly contains both verifiable and unverifiable information. Thus it behooves the internet users to develop resource evaluation and critical thinking skills in order to discern appropriate quality resources. Through review and comparison of the available checklists, the present paper endeavors to offer criteria for website evaluation

Mojdgan binesh

2008-07-01

341

Thyroid hormone profile and PELOD score in children with sepsis  

Directory of Open Access Journals (Sweden)

Full Text Available Background Thyroid hormonal dysfunction, also known as euthyroid sick syndrome or nonthyroidal illness, can be seen in sepsis. There have been few studies on thyroid hormone dysfunction in septic children, as well as on a relationship between their thyroid hormone profiles and pediatric logistic organ dysfunction (PELOD scores. Procalcitonin (PCT is one of the sepsis biomarker. Objective To evaluate the thyroid hormone profile in children with sepsis as well as to assess for a correlation between the thyroid levels and PELOD scores, PCT levels, and patient outcomes. Methods This cross-sectional study included children aged 1-18 years admitted to the pediatric intensive care unit (PICU with a primary diagnosis of sepsis. PELOD scores and thyroid hormonal levels were assessed once during the first 24 hours after PICU admission. Results Thirty subjects were included in the study. The median values of T3, free T4, and TSH were 45 (range 17-133 ng/dL, 0.81 (range 0.3-1.57 ng/dL, and 1.36 (range 0.05-7.78 ?IU/L, respectively. The T3, free T4, and TSH levels were decreased in 97%, 50% and 40% of the subjects. There were no significant differences between low and normal to high TSH with regards to the PELOD score (P=0.218, PCT level (P=0.694, or patient outcomes (P=0.55. The risk of death increased by 15 times among the subjects with PELOD score >20 compared to those with PELOD score <20 (OR 15; 95%CI: 1.535 to 146.545; P=0.012. Conclusion Thyroid hormones are decreased in septic children with the majority having low T3. A high PELOD score is strongly correlated with mortality and can be used as a prognostic parameter for septic children in the PICU, but there is no correlation with decreased TSH.[Paediatr Indones. 2014;54:245-50.].

Agung G. Tanurahardja

2014-07-01

342

Safety and reliability criteria  

International Nuclear Information System (INIS)

Nuclear power plants and, in particular, reactor pressure boundary components have unique reliability requirements, in that usually no significant redundancy is possible, and a single failure can give rise to possible widespread core damage and fission product release. Reliability may be required for availability or safety reasons, but in the case of the pressure boundary and certain other systems safety may dominate. Possible Safety and Reliability (S and R) criteria are proposed which would produce acceptable reactor design. Without some S and R requirement the designer has no way of knowing how far he must go in analysing his system or component, or whether his proposed solution is likely to gain acceptance. The paper shows how reliability targets for given components and systems can be individually considered against the derived S and R criteria at the design and construction stage. Since in the case of nuclear pressure boundary components there is often very little direct experience on which to base reliability studies, relevant non-nuclear experience is examined. (author)

343

Shwachman-Kulczycki score still useful to monitor cystic fibrosis severity  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUCTION: The Shwachman-Kulczycki score was the first scoring system used in cystic fibrosis to assess disease severity. Despite its subjectivity, it is still widely used. OBJECTIVE: To study correlations among forced expiratory volume in one second (FEV1, chest radiography, chest computed tomography, 6-minute walk test, and Shwachman-Kulczycki score in patients with cystic fibrosis and to test whether the Shwachman-Kulczycki score is still useful in monitoring the severity of the disease. METHODS: A cross-sectional prospective study was performed to analyze the correlations (Spearman. Patients with clinically stable cystic fibrosis, aged 3-21 years, were included. RESULTS: 43 patients, 19F/24M, mean age 10.5 + 4.7 years, with a median Shwachman-Kulczycki score of 70 were studied. The median Brasfield and Bhalla scores were 17 and 10, respectively. The mean Z score for the 6-minute walk test was -1.1 + 1.106 and the mean FEV1 was 59 + 26 (as percentage of predicted values. The following significant correlations versus the Shwachman-Kulczycki score were found: FEV1 (r = 0.76, 6-minute walk test (r = 0.71, chest radiography (r = 0.71 and chest computed tomography (r = -0.78. When patients were divided according to FEV1, a statistically significantly correlation with the Shwachman-Kulczycki score was found only in patients with FEV1 <70% (r = 0.67. CONCLUSIONS: The Shwachman-Kulczycki score remains an useful tool for monitoring the severity of cystic fibrosis, adequately reflecting the functional impairment and chest radiography and tomography changes, especially in patients with greater impairment of lung function. When assessing patients with mild lung disease its limitations should be considered and its usefulness in such patients should be evaluated in larger populations.

Fabíola Stollar

2011-01-01

344

Decision criteria in PSA applications  

Energy Technology Data Exchange (ETDEWEB)

Along with the adoption of risk informed decision making principles, the need for formal probabilistic decision rule or criteria has been risen. However, there are many practical and theoretical problems in the application of probabilistic criteria. One has to think what is the proper way to apply probabilistic rules together with deterministic ones and how the criteria are weighted with respect to each other. In this report, we approach the above questions from the decision theoretic point of view. We give a short review of the most well known probabilistic criteria, and discuss examples of their use. We present a decision analytic framework for evaluating the criteria, and we analyse how the different criteria behave under incompleteness or uncertainty of the PSA model. As the conclusion of our analysis we give recommendations on the application of the criteria in different decision situations. (au)

Holmberg, J.E.; Pulkkinen, U.; Rosqvist, T.; Simola, K. [VTT Automation (Finland)

2001-11-01

345

Decision criteria in PSA applications  

International Nuclear Information System (INIS)

Along with the adoption of risk informed decision making principles, the need for formal probabilistic decision rule or criteria has been risen. However, there are many practical and theoretical problems in the application of probabilistic criteria. One has to think what is the proper way to apply probabilistic rules together with deterministic ones and how the criteria are weighted with respect to each other. In this report, we approach the above questions from the decision theoretic point of view. We give a short review of the most well known probabilistic criteria, and discuss examples of their use. We present a decision analytic framework for evaluating the criteria, and we analyse how the different criteria behave under incompleteness or uncertainty of the PSA model. As the conclusion of our analysis we give recommendations on the application of the criteria in different decision situations. (au)

346

Improving personality facet scores with multidimensional computer adaptive testing : an illustration with the NEO PI-R  

DEFF Research Database (Denmark)

Narrowly defined personality facet scores are commonly reported and used for making decisions in clinical and organizational settings. Although these facets are typically related, scoring is usually carried out for a single facet at a time. This method can be ineffective and time consuming when personality tests contain many highly correlated facets. This article investigates the possibility of increasing the precision of the NEO PI-R facet scores by scoring items with multidimensional item response theory and by efficiently administering and scoring items with multidimensional computer adaptive testing (MCAT). The increase in the precision of personality facet scores is obtained from exploiting the correlations between the facets. Results indicate that the NEO PI-R could be substantially shorter without attenuating precision when the MCAT methodology is used. Furthermore, the study shows that the MCAT methodology is particularly appropriate for constructs that have many highly correlated facets.

Makransky, Guido; Mortensen, Erik Lykke

2013-01-01

347

Evaluation of a Lameness Scoring System for Dairy Cows  

DEFF Research Database (Denmark)

Lameness is a major problem in dairy production both in terms of reduced production and compromised animal welfare. A 5-point lameness scoring system was developed based on previously published systems, but optimized for use under field conditions. The scoring system included the words "in most cases" in the descriptions of the clinical signs evaluated. This was done to avoid a situation in which cows might not fit into any of the categories. Additionally, a number of clinical signs used in other lameness scoring systems, considered of less importance in relation to lameness, were not included. Only clinical signs were included that could easily be assessed within a few seconds from a distance. The scoring system was evaluated with intra-and interobserver agreement using kappa statistics. The evaluation was done before and after training 5 observers. Weighted kappa values ranged from 0.38 to 0.78 for intraobserver agreement, with mean kappa values across all observers of 0.60 and 0.53 before and after training, respectively. Weighted kappa values ranged from 0.24 to 0.68 for interobserver agreement, with mean kappa values across all pairs of observers of 0.48 and 0.52 before and after training, respectively. Training had only a limited positive effect on intra- and interobserver agreement. Additionally, how the different lameness categories are distributed along a theoretical scale representing the full spectrum of lameness from "absolutely normal gait" to "as lame as a cow can possibly be" was evaluated. This evaluation was done using the polychoric correlation coefficient. The estimated within-observer polychoric correlation coefficient ranged from 0.76 to 0.96, and there were no significant differences between the thresholds used to classify cows into different lameness categories by different observers before or after training. In conclusion, the results suggest that the lameness categories were not equidistant and the scoring system has reasonable reliability in terms of intra- and interobserver agreement

Thomsen, P T; Munksgaard, L

2008-01-01

348

A Method Based on DIMOND Quality Criteria to Evaluate Imaging in Diagnostic and Interventional Cardiology  

International Nuclear Information System (INIS)

Image quality criteria (IQC) for cine-angiography were recently settled. The aim of this study was to test whether these criteria allow a measurement of the quality of cine-angiograms. A questionnaire was derived from IQC where a binary response was required regarding the degree of visibility of anatomic or pathologic structures. Scores were given on a ranking scale. Two quality scores were defined (total score and minimum score) and standard deviation (SD) was assumed to be an indicator of the method's reproducibility. Data of the total score are presented for the first nine angiograms. Six experts obtained thirty-nine readings. The total scores ranged between 83 and 99% (SD 0.8-18.7%); 89% of the readings were within 4% of SD. This preliminary experience indicates that quality criteria can be translated into a scoring system that yields reproducible data in most instances. The analysis of the remaining angiograms will help in understanding how to improve these results. (author)

349

Awareness and use of cardiovascular risk scores by family physicians in southeastern Ontario  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Our objective was to determine the assessment of cardiovascular risk by family physicians. Methods: A questionnaire was sent by mail or fax regarding both awareness and use of the various CV risk scores in southeastern Ontario. Results: Of 181 family physicians surveyed, 96% were aware of at least one CV risk score and 40% were aware of the JUPITER study. Despite this awareness, 72% simply counted risk factors to assess risk, rather than to calculate risk using established scoring methods. Only 23% used the JUPITER study criteria. This suggests an under-estimated of overall CV risk by family physician’s practicing in southeastern Ontario. Interpetation: Cardiovascular risk in primary care is being underestimated in southeastern Ontario. Additional knowledge translation strategies are required to enhance the family physician’s awareness and use of established risk scoring methods if we are to reduce the burden of CV disease.

Murray F. Matangi

2013-11-01

350

64 slice MDCT generally underestimates coronary calcium scores as compared to EBT: A phantom study  

International Nuclear Information System (INIS)

The objective of our study was the determination of the influence of the sequential and spiral acquisition modes on the concordance and deviation of the calcium score on 64-slice multi-detector computed tomography (MDCT) scanners in comparison to electron beam tomography (EBT) as the gold standard. Our methods and materials were an anthropomorphic cardio CT phantom with different calcium inserts scanned in sequential and spiral acquisition modes on three identical 64-slice MDCT scanners of manufacturer A and on three identical 64-slice MDCT scanners of manufacturer B and on an EBT system. Every scan was repeated 30 times with and 15 times without a small random variation in the phantom position for both sequential and spiral modes. Significant differences were observed between EBT and 64-slice MDCT data for all inserts, both acquisition modes, and both manufacturers of MDCT systems. High regression coefficients (0.90-0.98) were found between the EBT and 64-slice MDCT data for both scoring methods and both systems with high correlation coefficients (R2>0.94). System A showed more significant differences between spiral and sequential mode than system B. Almost no differences were observed in scanners of the same manufacturer for the Agatston score and no differences for the Volume score. The deviations of the Agatston and Volume scores showed regression dependencies approximately equal to the square root of the absolute score. The Agatston and Volume scores ote score. The Agatston and Volume scores obtained with 64-slice MDCT imaging are highly correlated with EBT-obtained scores but are significantly underestimated (-10% to -2%) for both sequential and spiral acquisition modes. System B is more independent of acquisition mode to calcium score than system A. The Volume score shows no intramanufacturer dependency and its use is advocated versus the Agatston score. Using the same cut points for MDCT-based calcium scores as for EBT-based calcium scores can result in classifying individuals into a too low risk category. System information and scanprotocol is therefore needed for every calcium score procedure to ensure a correct clinical interpretation of the obtained calcium score results

351

7 CFR 1783.9 - What are the criteria for scoring applications?  

Science.gov (United States)

...area to be covered by the RFP loans, and appears likely to be sustainable. Up to 40 points. (3) Percentage of applicant...discretion, considering such factors as creative outreach ideas for marketing RFP loans to rural residents; the amount of funds...

2010-01-01

352

7 CFR 1740.8 - Scoring criteria for the grant competition.  

Science.gov (United States)

...coverage area, go to the FCC TV Query Web site (http://www.fcc.gov/fcc-bin...be found at the American Factfinder Web site http://factfinder.census.gov...of specialized human resources (such as teachers) for which digital educational...

2010-01-01

353

Laser Safety Inspection Criteria  

International Nuclear Information System (INIS)

A responsibility of the Laser Safety Officer (LSO) is to perform laser audits. The American National Standard Z136.1 Safe Use of Lasers references this requirement through several sections. One such reference is Section 1.3.2.8, Safety Features Audits, ''The LSO shall ensure that the safety features of the laser installation facilities and laser equipment are audited periodically to assure proper operation''. The composition, frequency and rigor of that inspection/audit rests in the hands of the LSO. A common practice for institutions is to develop laser audit checklists or survey forms It is common for audit findings from one inspector or inspection to the next to vary even when reviewing the same material. How often has one heard a comment, ''well this area has been inspected several times over the years and no one ever said this or that was a problem before''. A great number of audit items, and therefore findings, are subjective because they are based on the experience and interest of the auditor to particular items on the checklist. Beam block usage, to one set of eyes might be completely adequate, while to another, inadequate. In order to provide consistency, the Laser Safety Office of the National Ignition Facility Directorate has established criteria for a number of items found on the typical laser safety audit form. The criteria are distributed to laser users. It serves two broad purposes; first, it gives the user an expectation of what will be reviewed by an xpectation of what will be reviewed by an auditor. Second, it is an opportunity to explain audit items to the laser user and thus the reasons for some of these items, such as labelling of beam blocks

354

Random Walk Picture of Basketball Scoring  

CERN Document Server

We present evidence, based on play-by-play data from all 6087 games from the 2006/07--2009/10 seasons of the National Basketball Association (NBA), that basketball scoring is well described by a weakly-biased continuous-time random walk. The time between successive scoring events follows an exponential distribution, with little memory between different scoring intervals. Using this random-walk picture that is augmented by features idiosyncratic to basketball, we account for a wide variety of statistical properties of scoring, such as the distribution of the score difference between opponents and the fraction of game time that one team is in the lead. By further including the heterogeneity of team strengths, we build a computational model that accounts for essentially all statistical features of game scoring data and season win/loss records of each team.

Gabel, Alan

2011-01-01

355

Correlation of patient entry rates and physician documentation errors in dictated and handwritten emergency treatment records.  

Science.gov (United States)

This study was designed to examine the relationship between patient entry rates (a measure of physician work load) and documentation errors/omissions in both handwritten and dictated emergency treatment records. The study was carried out in two phases. Phase I examined handwritten records and Phase II examined dictated and transcribed records. A total of 838 charts for three common chief complaints (chest pain, abdominal pain, asthma/chronic obstructive pulmonary disease) were retrospectively reviewed and scored for the presence or absence of 11 predetermined criteria. Patient entry rates were determined by reviewing the emergency department patient registration logs. The data were analyzed using simple correlation and linear regression analysis. A positive correlation was found between patient entry rates and documentation errors in handwritten charts. No such correlation was found in the dictated charts. We conclude that work load may negatively affect documentation accuracy when charts are handwritten. However, the use of dictation services may minimize or eliminate this effect. PMID:9115506

Dawdy, M R; Munter, D W; Gilmore, R A

1997-03-01

356

Overexpression of epidermal growth factor receptor as a prognostic factor in colorectal cancer on the basis of the Allred scoring system  

Directory of Open Access Journals (Sweden)

Full Text Available Marta Rokita,1 Rafal Stec,1 Lubomir Bodnar,1 Radoslaw Charkiewicz,2 Jan Korniluk,1 Marta Smoter,1 Marzena Cichowicz,3 Lech Chyczewski,4 Jacek Nikli?ski,2 Wojciech Koz?owski,3 Cezary Szczylik11Department of Oncology, Military Institute of Medicine, Central Teaching Hospital, Warsaw, Poland; 2Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland; 3Department of Pathology, Military Institute of the Health Services in Warsaw, Warsaw, Poland; 4Department of Clinical Pathology, Medical University of Bialystok, Bialystok, PolandBackground: Overexpression of epidermal growth factor receptor (EGFR is found in many types of neoplasms. The aim of the study was to evaluate EGFR expression in colorectal cancer (CRC specimens and to determine whether EGFR expression correlates with clinicopathological data and overall survival.Patients and methods: Tissue specimens from 181 consecutive CRC patients treated at the Military Institute of Medicine in 2006–2010 were collected and examined for EGFR expression, by immunohistochemistry staining. The staining intensity and percentage of cells with membranous EGFR expression were scored and then grouped according to the parameters of the Allred Scoring system. Cutoff values were subjected to further statistical analysis. Univariate tests and a multivariate Cox proportional hazards model were used in data analysis.Results: EGFR was overexpressed in 96 of 181 CRC specimens (53%. EGFR expression was not correlated with other clinicopathological variables. On univariate analysis, overexpression of EGFR, determined by PS (percentage score (>3 and total score (sum of PS and intensity score (>4, was associated with poor overall survival. On multivariate analysis, EGFR overexpression (PS > 3 was an independent adverse prognostic factor (hazard ratio [HR] 1.62; 95% confidence interval [CI]: 1.03–2.53. Elevated carcinoembryonic antigen (CEA serum concentration before treatment, performance status (Word Health Organization [WHO]-2, and tumor localized in colon and liver metastases were also independent unfavorable prognostic factors.Conclusion: EGFR overexpression (PS > 3 in a CRC patient population was an independent adverse prognostic factor. Implementation of the Allred Scoring system criteria into clinical practice might facilitate treatment decisions in CRC patients.Keywords: expression, receptor, prognosis, cancer

Rokita M

2013-07-01

357

Propensity Score Weighting with Multilevel Data  

OpenAIRE

Propensity score methods are being increasingly used as a less parametric alternative to traditional regression to balance observed differences across groups in both descriptive and causal comparisons. Data collected in many disciplines often have analytically relevant multilevel or clustered structure. The propensity score, however, was developed and has been used primarily with unstructured data. We present and compare several propensity-score-weighted estimators for clustered data, includi...

Li, Fan; Zaslavsky, Alan M.; Landrum, Mary Beth

2013-01-01

358

Weight Trimming and Propensity Score Weighting  

OpenAIRE

Propensity score weighting is sensitive to model misspecification and outlying weights that can unduly influence results. The authors investigated whether trimming large weights downward can improve the performance of propensity score weighting and whether the benefits of trimming differ by propensity score estimation method. In a simulation study, the authors examined the performance of weight trimming following logistic regression, classification and regression trees (CART), boosted CART, a...

Lee, Brian K.; Lessler, Justin; Stuart, Elizabeth A.

2011-01-01

359

Random Walk Picture of Basketball Scoring  

OpenAIRE

We present evidence, based on play-by-play data from all 6087 games from the 2006/07--2009/10 seasons of the National Basketball Association (NBA), that basketball scoring is well described by a weakly-biased continuous-time random walk. The time between successive scoring events follows an exponential distribution, with little memory between different scoring intervals. Using this random-walk picture that is augmented by features idiosyncratic to basketball, we account for ...

Gabel, Alan; Redner, S.

2011-01-01

360

Scoring Play Combinatorial Games Under Different Operators  

CERN Document Server

Scoring play games were first studied by Fraser Stewart for his PhD thesis. He showed that under the disjunctive sum, scoring play games are partially ordered, but do not have the same "nice" structure of normal play games. In this paper I will be considering scoring play games under three different operators given by John Conway and William Stromquist and David Ullman, namely the conjunctive sum, selective sum and sequential join.

Stewart, Fraser

2012-01-01

361

Mapping Inundation Uncertainty with a Standard Score (Z-Score) Technique  

Science.gov (United States)

Vertical error in the topographic data is the most important factor affecting the accuracy of single value surface model inundation maps (NRC, 2009). A single value surface model, often referred to as a ‘bathtub’ model, requires two primary topographic input variables: (1) the water surface (i.e. tidal datum + inundation level), and (2) the ground elevation. Unfortunately, both variables include spatially varying vertical error that introduces uncertainty into the resultant map for a given inundation scenario. More sophisticated hydraulic and geomorphic models have their own error budgets, which can be quite complex depending on model assumptions. Standard scores, or z-scores, measure the number of standard deviations an observation falls above or below the mean. This investigation employs z-scores to map the uncertainty introduced by the propagated error associated with the topographic variables. The technique permits greater flexibility than existing uncertainty methods which map the horizontal extension of the elevation data at the 95% confidence level. The vertical error in the water surface variable is due to uncertainties and spatial variability in the hydrodynamic models which drive the tidal datum conversions. The National Geodetic Survey’s (NGS) Vertical Datum Transformation Tool (VDatum) software can be used to convert between tidally referenced and orthometric elevations, but depending on location, results in errors on the order of 5-20 cm. An additional source of uncertainty is the elevation data itself. Most inundation mapping applications employ Digital Elevation Models (DEM) derived from topographic lidar data. Although lidar is among the most accurate large area elevation collection techniques, it has limitations in certain land cover types (e.g. forest or estuarine marsh), and its vertical accuracy can vary both within and between collections. To quantify this variability, accuracy assessments are performed to determine the vertical root mean square error (RMSEZ) of the lidar data. After combining the RMSEZ with the water surface error, a z-score can be calculated for each grid cell in the DEM. The resultant z-scores can then be expressed as a cumulative probability, or rank of ‘uncertainty’. Because the two error sources are not correlated, the propagated error can be calculated using the square root of the sum of the squared errors. An important assumption is that the propagated error has a normal and non-biased distribution; the error is assumed to equal the standard deviation and the computation of z-scores requires a normal distribution. An elevation related error that is not included in the model is the inaccuracy of extending the tidal corrections landward and will vary with modeled inundation levels; VDatum grids are currently limited to a short distance landward from the shoreline. The result is a map of ‘uncertainty’ as opposed to depths or elevations, which can be mapped at any desired level of probability. The technique can accommodate various spatial and non-spatial error estimates. Incorporation of ‘geomorphic uncertainty’ is also explored and may provide a link between the often-used and simple ‘bath tub’ model and more complex geomorphic models.

Hadley, B. C.; Schmid, K. A.; Waters, K. J.; Marcy, D. C.

2010-12-01

362

Profile and genetic parameters of dairy cattle locomotion score and lameness across lactation.  

Science.gov (United States)

This study investigated the profile of locomotion score and lameness before the first calving and throughout the first (n=237) and second (n=66) lactation of 303 Holstein cows raised on a commercial farm. Weekly heritability estimates of locomotion score and lameness, and their genetic and phenotypic correlations with milk yield, body condition score, BW and reproduction traits were derived. Daughter future locomotion score and lameness predictions from their sires??? breeding values for conformation traits were also calculated. First-lactation cows were monitored weekly from 6 weeks before calving to the end of lactation. Second-lactation cows were monitored weekly throughout lactation. Cows were locomotion scored on a scale from one (sound) to five (severely lame); a score greater than or equal to two defined presence of lameness. Cows??? weekly body condition score and BW was also recorded. These records were matched to corresponding milk yield records, where the latter were 7-day averages on the week of inspection. The total number of repeated records amounted to 12 221. Data were also matched to the farm???s reproduction database, from which five traits were derived. Statistical analyses were based on uni- and bivariate random regression models. The profile analysis showed that locomotion and lameness problems in first lactation were fewer before and immediately after calving, and increased as lactation progressed. The profile of the two traits remained relatively constant across the second lactation. Highest heritability estimates were observed in the weeks before first calving (0.66 for locomotion score and 0.54 for lameness). Statistically significant genetic correlations were found for first lactation weekly locomotion score and lameness with body condition score, ranging from ???0.31 to ???0.65 and from ???0.44 to ???0.76, respectively, suggesting that cows genetically pre-disposed for high body condition score have fewer locomotion and lameness issues. Negative (favourable) phenotypic correlations between first lactation weekly locomotion score/lameness and milk yield averaged ???0.27 and ???0.17, respectively, and were attributed to management factors. Also a phenotypic correlation between lameness and conception rate of ???0.19 indicated that lame cows were associated with lower success at conceiving. First-lactation daughter locomotion score and/or lameness predictions from sires??? estimated breeding values for conformation traits revealed a significant linear effect of rear leg side view, rear leg rear view, overall conformation, body condition score and locomotion, and a quadratic effect of foot angle. PMID:24153101

Kougioumtzis, A; Valergakis, G E; Oikonomou, G; Arsenos, G; Banos, G

2014-01-01

363

CORRELATION AND REGRESSION  

Science.gov (United States)

Webcast entitled Statistical Tools for Making Sense of Data, by the National Nutrient Criteria Support Center, N-STEPS (Nutrients-Scientific Technical Exchange Partnership. The section "Correlation and Regression" provides an overview of these two techniques in the context of nut...

364

Scoring Function Based on Weighted Residue Network  

Directory of Open Access Journals (Sweden)

Full Text Available Molecular docking is an important method for the research of protein-protein interaction and recognition. A protein can be considered as a network when the residues are treated as its nodes. With the contact energy between residues as link weight, a weighted residue network is constructed in this paper. Two weighted parameters (strength and weighted average nearest neighbors’ degree are introduced into this model at the same time. The stability of a protein is characterized by its strength. The global topological properties of the protein-protein complex are reflected by the weighted average nearest neighbors’ degree. Based on this weighted network model and these two parameters, a new docking scoring function is proposed in this paper. The scoring and ranking for 42 systems’ bound and unbounded docking results are performed with this new scoring function. Comparing the results obtained from this new scoring function with that from the pair potentials scoring function, we found that this new scoring function has a similar performance to the pair potentials on some items, and this new scoring function can get a better success rate. The calculation of this new scoring function is easy, and the result of its scoring and ranking is acceptable. This work can help us better understand the mechanisms of protein-protein interactions and recognition.

Shan Chang

2011-12-01

365

Criteria for evaluation of theory.  

Science.gov (United States)

This column presents criteria for evaluation of nursing theories specified by Jacqueline Fawcett and Rosemarie Rizzo Parse. Fawcett's criteria are significance, internal consistency, parsimony, testability, empirical adequacy, and pragmatic adequacy. Some of those criteria are differentiated for grand theories and middle-range theories but are not differentiated by type of data-qualitative or quantitative-used to develop the theory. Parse's criteria are structure and process. Structure encompasses historical evolution, foundational elements, and relational statements. Process encompasses correspondence, coherence, and pragmatics. Parse's criteria are appropriate for the critical appraisal of all frameworks and theories, regardless of level of abstraction. Parse also presents a comparison of her own and Fawcett's criteria. PMID:15802745

Fawcett, Jacqueline

2005-04-01

366

Gleason score as predictor of clinicopathologic findings and biochemical (PSA progression following radical prostatectomy  

Directory of Open Access Journals (Sweden)

Full Text Available OBJECTIVE: There is evidence showing that Gleason grading of prostatic adenocarcinoma is one of the most powerful predictors of biological behavior and one of the most influential factors used to determine treatment for prostate cancer. The aim of the current study was to compare the Gleason score for needle biopsy to the Gleason score for the correspondent surgical specimen, find any possible difference in the biochemical (PSA progression following surgery in upgraded cases, correlate Gleason score in the specimens to several clinicopathologic variables, and compare outcomes between patients with low-grade vs. high-grade Gleason and Gleason scores 3+4 vs. 4+3. MATERIALS AND METHODS: The study population consisted of 200 consecutive patients submitted to radical prostatectomy. Biochemical progression was defined as PSA > 0.2 ng/mL. Time to PSA progression was studied using the Kaplan-Meier product-limit analysis. RESULTS: In 47.1% of the cases, there was an exact correlation and 40.6% of cases were underestimated in the biopsies. Half of the tumors graded Gleason 6 at biopsy were Gleason score 7 at surgery. These upgraded tumors had outcomes similar to tumors with Gleason score 7 in both biopsy and surgery. There was a positive correlation of high-grade Gleason score in the surgical specimens to higher preoperative PSA, more extensive tumors, positive margins and more advanced pathologic staging. Tumors with a Gleason score > 7 have lower PSA progression-free survival vs. Gleason scores < 7. In this series, there was no significant difference when comparing Gleason scores of 3+4 vs. 4+3. CONCLUSIONS: The findings support the importance of Gleason grading for nomograms, which are used by clinicians to counsel individual patients and help them make important decisions regarding their disease.

Marbele S. Guimaraes

2008-02-01

367

Low amniotic fluid index in high risk pregnancy and poor apgar score at birth  

International Nuclear Information System (INIS)

To determine the accuracy of antepartum Amniotic Fluid Index (AFI) of 5 cm was labeled as predictor of good outcome at birth. The subjects in both the groups were demographically matched and fulfilled the inclusion and exclusion criteria. The Apgar score was calculated at 5 minutes of birth. The newborns, with Apgar score 6 were labeled as healthy. AFI was compared with Apgar score, using Chi-square and a p-value was calculated to determine the statistical significance. Sensitivity, specificity, efficiency and the predictive values of AFI at a cut off point of < 5 cm as a predictor of adverse outcome at birth (Apgar score of < 6 at 5 minutes of birth) in high-risk pregnancy were calculated. Only 8 neonates of 50 women with low AFI had low Apgar score. Similarly, 6 neonates of 50 women with normal AFI had poor Apgar score. The diagnostic sensitivity, specificity, positive predictive value, negative predictive value and efficiency of AFI as test were 57.1%, 51.3%, 16%, 88% and 52% respectively. Low AFI is a poo88% and 52% respectively. Low AFI is a poor predictor of adverse outcome for high-risk term patients. AFI is not a good screening test for high-risk pregnant women at term for birth of an infant with low Apgar score. (author)

368

Laser Safety Inspection Criteria  

International Nuclear Information System (INIS)

A responsibility of the Laser Safety Officer (LSO) is to perform laser safety audits. The American National Standard Z136.1 Safe use of Lasers references this requirement in several sections: (1) Section 1.3.2 LSO Specific Responsibilities states under Hazard Evaluation, ''The LSO shall be responsible for hazards evaluation of laser work areas''; (2) Section 1.3.2.8, Safety Features Audits, ''The LSO shall ensure that the safety features of the laser installation facilities and laser equipment are audited periodically to assure proper operation''; and (3) Appendix D, under Survey and Inspections, it states, ''the LSO will survey by inspection, as considered necessary, all areas where laser equipment is used''. Therefore, for facilities using Class 3B and or Class 4 lasers, audits for laser safety compliance are expected to be conducted. The composition, frequency and rigueur of that inspection/audit rests in the hands of the LSO. A common practice for institutions is to develop laser audit checklists or survey forms. In many institutions, a sole Laser Safety Officer (LSO) or a number of Deputy LSO's perform these audits. For that matter, there are institutions that request users to perform a self-assessment audit. Many items on the common audit list and the associated findings are subjective because they are based on the experience and interest of the LSO or auditor in particular items on the checklist. Beam block usage is an example; to one set of eyes a particular aexample; to one set of eyes a particular arrangement might be completely adequate, while to another the installation may be inadequate. In order to provide more consistency, the National Ignition Facility Directorate at Lawrence Livermore National Laboratory (NIF-LLNL) has established criteria for a number of items found on the typical laser safety audit form. These criteria are distributed to laser users, and they serve two broad purposes: first, it gives the user an expectation of what will be reviewed by an auditor, and second, it is an opportunity to explain audit items to the laser user and thus the reasons for some of these items. Some examples are given from the audit criteria handout. As an explanatory key to the reader, an Operational Safety Procedure (OSP) as a formally reviewed safety procedure required for all Class 3B and Class 4 laser installations. An ''OSP Binder'' contains all safety documentation related to a given laser operation and serves as a central repository for documents, such as the OSP, interlock logs, lessons learned, contact information etc. ''Unattended Operation'' refers to approved procedures for unattended operation of the laser installation and may include operation beyond normal working hours. ''L-train'' is the LLNL training tracking system

369

Immunohistochemical evaluation of hormone receptors in breast cancer: which scoring system is suitable for highly sensitive procedures?  

Science.gov (United States)

To evaluate hormone receptors immunohistochemically, standardized staining procedures and scoring systems are required. The authors previously reported that highly sensitive procedures affected basic factors for technical validation. The aim of the present study was to show the characteristics of scoring systems for highly sensitive procedures. To examine how highly sensitive procedures enhance the staining intensity and increase the positive cell population, two different staining methods were compared. To evaluate scoring systems, three systems--cell counting score, modified immunoreactive score, and H score--were compared using the same samples stained by an autostaining system. It was found that the highly sensitive procedure increased the positive cell population, especially in breast cancers with a low enzyme immunoassay (EIA) level of less than 100 fmol/mg, and strengthened the staining intensity. This enhancement led to a correlation in a logarithmic curve rather than a linear correlation by all three scoring systems. The results showed that scoring systems including a factor of staining intensity did not have an absolute advantage because boosted staining intensity by highly sensitive procedure did not reflect EIA value or protein contents accurately. To the authors' knowledge, there is no report discussing the nonlinear correlation between biochemical and immunohistochemical assay by highly sensitive procedures; however, it is important to select a scoring system and threshold based on nonlinear correlation. PMID:15163012

Umemura, Shinobu; Itoh, Johbu; Itoh, Hitoshi; Serizawa, Akihiko; Saito, Yuki; Suzuki, Yasuhiro; Tokuda, Yutaka; Tajima, Tomoo; Osamura, R Yoshiyuki

2004-03-01

370

Zertifikat Deutsch als Fremdsprache and the Oral Proficiency Interview: A Comparison of Test Scores and Examinations.  

Science.gov (United States)

Investigates what correlations might exist between an individual's score on the Zertifikat Deutsch als Fremdsprache and on the Oral Proficiency Interview. The tests themselves are briefly described. Results indicate that the two tests appear to correlate well in their evaluation of speaking skills. (SED)

Lalande, John F.; Schweckendiek, Jurgen

1986-01-01