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Sample records for sclerotic bony lesion

  1. Cystinosis with sclerotic bone lesions.

    Science.gov (United States)

    Sirrs, S; Munk, P; Mallinson, P I; Ouellette, H; Horvath, G; Cooper, S; Da Roza, G; Rosenbaum, D; O'Riley, M; Nussbaumer, G; Hoang, L N; Lee, C H

    2014-01-01

    A 26-year-old male with nephropathic cystinosis treated with cysteamine and renal transplantation presented for evaluation of multiple sclerotic bone lesions, which were an incidental finding on chest computerized tomography. These lesions were in a pattern consistent with osteoblastic metastases. He did not have a history of clinically significant hyperparathyroidism or cytopenias either preceding or following his transplant. Bone and tumor markers (including alkaline phosphatase and calcium) were all normal. A percutaneous bone biopsy of the lesions showed changes compatible with cystine deposition. Our case demonstrates that sclerotic bone lesions can be a feature of cystinosis in patients with normal parathyroid function and that significant bone marrow infiltration with cystine can be present even in the absence of cytopenias. PMID:24097416

  2. Cystinosis with Sclerotic Bone Lesions

    OpenAIRE

    Sirrs, S.; Munk, P.; Mallinson, P. I.; Ouellette, H.; Horvath, G.; Cooper, S.; Da Roza, G.; Rosenbaum, D.; O’riley, M.; Nussbaumer, G.; Hoang, L. N.; Lee, C. H.

    2013-01-01

    A 26-year-old male with nephropathic cystinosis treated with cysteamine and renal transplantation presented for evaluation of multiple sclerotic bone lesions, which were an incidental finding on chest computerized tomography. These lesions were in a pattern consistent with osteoblastic metastases. He did not have a history of clinically significant hyperparathyroidism or cytopenias either preceding or following his transplant. Bone and tumor markers (including alkaline phosphatase and calcium...

  3. [Bony Bankart lesions].

    Science.gov (United States)

    Spiegl, U J; Braun, S; Euler, S A; Warth, R J; Millett, P J

    2014-12-01

    Fractures of the anteroinferior glenoid rim, termed bony Bankart lesions, have been reported to occur in up to 22% of first time anterior shoulder dislocations. The primary goal of treatment is to create a stable glenohumeral joint and a good shoulder function. Options for therapeutic intervention are largely dependent on the chronicity of the lesion, the activity level of the patient and postreduction fracture characteristics, such as the size, location and number of fracture fragments. Non-operative treatment can be successful for small, acute fractures, which are anatomically reduced after shoulder reduction. However, in patients with a high risk profile for recurrent instability initial Bankart repair is recommended. Additionally, bony fixation is recommended for acute fractures that involve more than 15-20% of the inferior glenoid diameter. On the other hand chronic fractures are generally managed on a case-by-case basis depending on the amount of fragment resorption and bony erosion of the anterior glenoid with high recurrence rates under conservative therapy. When significant bone loss of the anterior glenoid is present, anatomical (e.g. iliac crest bone graft and osteoarticular allograft) or non-anatomical (e.g. Latarjet and Bristow) reconstruction of the anterior glenoid is often indicated. PMID:25492582

  4. Occult bony lesions associated with anterior cruciate ligament injury

    International Nuclear Information System (INIS)

    To examine bony lesions associated with anterior cruciate ligament (ACL) injuries, magnetic resonance (MR) imaging was performed on 55 knees with ACL injuries. With respect to the period between ACL injuries and MR imaging, the knees were divided into acute (within one month), subacute (from one month to one year) and chronic (over one year) groups, containing 19, 16 and 20 knees, respectively. Occult bony lesions not shown in roentgenography were observed more frequently in the acute group (13/19) than in the other two groups (subacute group, 5/16; chronic group, 1/20), located in the lateral compartment of the knee joint. In the acute group, bony lesions had high signal intensity on T2-weighted images and low signal intensity on proton density images. In the subacute and chronic groups, bony lesions were less pronounced and had low signal intensity on T2-weighted images. These findings suggest that bony lesions are frequently associated with and occur simultaneously with ACL injury. (author)

  5. A radiographic study on experimental bony lesions

    International Nuclear Information System (INIS)

    The author studied the effect of periapical bone loss on radiographic interpretation by using a dry adult human mandible. Artificial bone lesions were created at the apices of two mandibular second molars and four mandibular bicuspids. The jaw was stabilized and various artificial lesions were radiographed under ideal circumstances. Radiographic pictures were recorded and compared with the size of the actual lesions. The obtained results were as follows: 1. The size of actual lesions were always larger than their radiographic pictures. 2. The size of actual lesion had a greater discrepancy in the molar area where the cortical plates were thick, but the lesions in the bicuspid areas were slightly larger than their radiographic pictures, and in these areas the cortical plates were quite thin. 3. Periapical lesions located in cancellous bone did not appear on a radiograph, regardless of the size of created lesion, but when the junctional bone was involved or the cortical plate was perforated, the define bone destructive change was observes on the roentgenogram. 4. Removal of the entire buccal or lingual plate did not affect the trabecular pattern of bone on the roentgenogram. 5. When the cancellous bone and junctional bone were removed simultaneously, altered trabecular patterns were observes on the roentgenogram.

  6. Injury of anterior cruciate ligament with associated bony lesions: MR image

    International Nuclear Information System (INIS)

    To evaluate the characteristic MR findings in injury of the anterior cruciate ligament (ACL) with associated bony lesions. We reviewed MR findings and the corresponding arthroscopic or operative results of 48 patients with ACL injuries, and evaluated ACL signal intensity and contour. In associated bony lesions, we determined the location of avulsion fracture and bony bruise. Complete ACL tears were seen in 27 cases, partial tears in 13, and avulsion injury in eight. Complete tears showed heterogeneously increased signal intensity with contour bulging in ten cases (37%), and combined bony lesion in 14 (52%). ACL with a thin continous low signal intensity band surrounding heterogeneously-increased signal intensity suggested partial tears, and was seen in three of 13 proven cases (23%) of partial ACL tears;combined bony lesion was seen in four such cases(31%). There were eight cases of avulsion fracture;the most frequent site was the anterolateral portion of the tibial spine (n=6). The most frequent sites of bony lesion were at the midportion of the lateral femoral condyle (n=6), and the posterior portion of the lateral tibial plateau (n=6);the next most frequent site was the anterior portion of the lateral tibial plateau (n=5). Tearing of the ACL was seen on MRI as ligament discontinuity, and heterogeneously increased signal intensity with ACL contour bulging. The most frequent sites of associated bony lesions were the midportion of the lateral femoral condyle, and the n of the lateral femoral condyle, and the posterior portion of the lateral tibial plateau. In associated bony lesions, bony contusion suggested ACL tearing, but avulsion fracture suggested ligament avulsion injury without tear

  7. Arthroscopic Transtendinous Modified Double-Row Suture Bridge Repair of a Bony PASTA Lesion

    OpenAIRE

    Johnson, Jeffrey S.; Caldwell, Paul E.; Pearson, Sara E.

    2014-01-01

    Surgical and conservative management of partial tears of the rotator cuff has long been a controversial topic for many generations of shoulder surgeons. These tears frequently occur on both the articular and bursal surfaces and within the intrasubstance of the rotator cuff. The term “PASTA lesion” describes the partial articular supraspinatus tendon avulsion–type injury. A less common variant of this injury is the bony PASTA lesion or partial articular bony avulsion of the supraspinatus...

  8. Arthroscopic Transtendinous Modified Double-Row Suture Bridge Repair of a Bony PASTA Lesion.

    Science.gov (United States)

    Johnson, Jeffrey S; Caldwell, Paul E; Pearson, Sara E

    2014-08-01

    Surgical and conservative management of partial tears of the rotator cuff has long been a controversial topic for many generations of shoulder surgeons. These tears frequently occur on both the articular and bursal surfaces and within the intrasubstance of the rotator cuff. The term "PASTA lesion" describes the partial articular supraspinatus tendon avulsion-type injury. A less common variant of this injury is the bony PASTA lesion or partial articular bony avulsion of the supraspinatus tendon (PABAST). PMID:25264507

  9. CT findings of nasomaxillary lesions: differential diagnosis by adjacent bony abnormality on CT

    International Nuclear Information System (INIS)

    To provide an aid in differential diagnosis of nasomaxillary lesions by CT appearance of bony changes, we retrospectively evaluated 82 computed tomographic (CT) examinations of 79 patients who had nasomaxillary lesions (56 tumors, 23 inflammations). The bony changes were classified as destruction, displacement, and sclerosis. Destruction of bony maxilla was most common in malignancy, in which more than 3 walls were often destroyed. Displacement of bony maxilla was most common in benign tumors and in slowly - growing malignant tumors such as adenoid cystic carcinoma or lymphoma, and there was often associated bony destruction of other walls. Sclerosis was a common finding in the inflammatory process, especially in chronic maxillary sinusitis with bony destruction at the ostium of the medial wall, Sclerosis often occurred after radiotherapy and / or chemotherapy of tumors and was also noted when there was associated inflammation. Maxillary cysts showed characteristic expansion of all sinus walls. Bony changes were less prominent in the tumors of the nasal cavity compared to the changes seen in the maxillary lesions. A careful analysis of CT findings is very helpful in differentiating malignant from benign tumors and inflammatory disease in nasomaxillary lesions

  10. CT findings of nasomaxillary lesions: differential diagnosis by adjacent bony abnormality on CT

    Energy Technology Data Exchange (ETDEWEB)

    Park, Yeon Won; Jung, Dong Kwang; Huh, Jin Do; Kim, Ho Joon; Chun, Byung Hee; Joh, Young D. [Kosin Medical College, Busan (Korea, Republic of)

    1991-07-15

    To provide an aid in differential diagnosis of nasomaxillary lesions by CT appearance of bony changes, we retrospectively evaluated 82 computed tomographic (CT) examinations of 79 patients who had nasomaxillary lesions (56 tumors, 23 inflammations). The bony changes were classified as destruction, displacement, and sclerosis. Destruction of bony maxilla was most common in malignancy, in which more than 3 walls were often destroyed. Displacement of bony maxilla was most common in benign tumors and in slowly - growing malignant tumors such as adenoid cystic carcinoma or lymphoma, and there was often associated bony destruction of other walls. Sclerosis was a common finding in the inflammatory process, especially in chronic maxillary sinusitis with bony destruction at the ostium of the medial wall, Sclerosis often occurred after radiotherapy and / or chemotherapy of tumors and was also noted when there was associated inflammation. Maxillary cysts showed characteristic expansion of all sinus walls. Bony changes were less prominent in the tumors of the nasal cavity compared to the changes seen in the maxillary lesions. A careful analysis of CT findings is very helpful in differentiating malignant from benign tumors and inflammatory disease in nasomaxillary lesions.

  11. Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized

    Science.gov (United States)

    Hunter, David J; Gerstenfeld, Lou; Bishop, Gavin; Davis, A David; Mason, Zach D; Einhorn, Tom A; Maciewicz, Rose A; Newham, Pete; Foster, Martyn; Jackson, Sonya; Morgan, Elise F

    2009-01-01

    Introduction Although the presence of bone marrow lesions (BMLs) on magnetic resonance images is strongly associated with osteoarthritis progression and pain, the underlying pathology is not well established. The aim of the present study was to evaluate the architecture of subchondral bone in regions with and without BMLs from the same individual using bone histomorphometry. Methods Postmenopausal female subjects (n = 6, age 48 to 90 years) with predominantly medial compartment osteoarthritis and on a waiting list for total knee replacement were recruited. To identify the location of the BMLs, subjects had a magnetic resonance imaging scan performed on their study knee prior to total knee replacement using a GE 1.5 T scanner with a dedicated extremity coil. An axial map of the tibial plateau was made, delineating the precise location of the BML. After surgical removal of the tibial plateau, the BML was localized using the axial map from the magnetic resonance image and the lesion excised along with a comparably sized bone specimen adjacent to the BML and from the contralateral compartment without a BML. Cores were imaged via microcomputed tomography, and the bone volume fraction and tissue mineral density were calculated for each core. In addition, the thickness of the subchondral plate was measured, and the following quantitative metrics of trabecular structure were calculated for the subchondral trabecular bone in each core: trabecular number, thickness, and spacing, structure model index, connectivity density, and degree of anisotropy. We computed the mean and standard deviation for each parameter, and the unaffected bone from the medial tibial plateau and the bone from the lateral tibial plateau were compared with the affected BML region in the medial tibial plateau. Results Cores from the lesion area displayed increased bone volume fraction but reduced tissue mineral density. The samples from the subchondral trabecular lesion area exhibited increased trabecular thickness and were also markedly more plate-like than the bone in the other three locations, as evidenced by the lower value of the structural model index. Other differences in structure that were noted were increased trabecular spacing and a trend towards decreased trabecular number in the cores from the medial location as compared with the contralateral location. Conclusions Our preliminary data localize specific changes in bone mineralization, remodeling and defects within BMLs features that are adjacent to the subchondral plate. These BMLs appear to be sclerotic compared with unaffected regions from the same individual based on the increased bone volume fraction and increased trabecular thickness. The mineral density in these lesions, however, is reduced and may render this area to be mechanically compromised, and thus susceptible to attrition. PMID:19171047

  12. Solitary Sclerotic Fibroma

    OpenAIRE

    Bhambri, Avani; Del Rosso, James Q.

    2009-01-01

    Sclerotic fibroma is a rare skin neoplasm that can be seen sporadically or in association with disorders such as Cowden’s disease. We present a case of solitary sclerotic fibroma that presented as an asymptomatic nodule in a 40-year-old man with no evidence of Cowden’s disease. Histopathologically, the lesion was consistent with a sclerotic fibroma displaying hypocellular collagen bundles with clefts.

  13. The “Double-Pulley” Technique for Arthroscopic Fixation of Partial Articular-Side Bony Avulsion of the Supraspinatus Tendon: A Rare Case of Bony PASTA Lesion

    OpenAIRE

    Murena, Luigi; Canton, Gianluca; Falvo, Daniele A.; Genovese, Eugenio A.; Surace, Michele F.; Cherubino, Paolo

    2012-01-01

    We report the use of the double-pulley technique for arthroscopic fixation of the bony PASTA (partial articular surface tendon avulsion) lesion. Arthroscopic examination documented a 15-mm-long and 8-mm-wide comminuted bony avulsion with 2 main fragments. Two double-loaded suture anchors were placed with a transtendinous technique at the anterior and posterior edges of the lesion respecting the tendon insertion to the avulsed fragment. The medial sutures were retrieved through the intact supr...

  14. Bony change of apical lesion healing process using fractal analysis

    International Nuclear Information System (INIS)

    To investigate the change of bone healing process after endodontic treatment of the tooth with an apical lesion by fractal analysis. Radiographic images of 35 teeth from 33 patients taken on first diagnosis, 6 months, and 1 year after endodontic treatment were selected. Radiographic images were taken by JUPITER computerized Dental X-ray System. Fractal dimensions were calculated three times at each area by Scion Image PC program. Rectangular region of interest (30 x 30) were selected at apical lesion and normal apex of each image. The fractal dimension at apical lesion of first diagnosis (L0) is 0.940 ± 0.361 and that of normal area (N0) is 1.186 ± 0.727 (p1) is 1.076 ± 0.069 and that of normal area (N1) is 1.192 ± 0.055 (p2) is 1.163 ± 0.074 and that of normal area (N2) is 1.225 ± 0.079 (p<0.05). After endodontic treatment, the fractal dimensions at each apical lesions depending on time showed statistically significant difference. And there are statistically significant different between normal area and apical lesion on first diagnosis, 6 months after, 1 year after. But the differences were grow smaller as time flows. The evaluation of the prognosis after the endodontic treatment of the apical lesion was estimated by bone regeneratioon was estimated by bone regeneration in apical region. Fractal analysis was attempted to overcome the limit of subjective reading, and as a result the change of the bone during the healing process was able to be detected objectively and quantitatively.

  15. A 36-year-old Man With Endobronchial Lesion and Bony Destruction of Ribs and Sacrum.

    Science.gov (United States)

    Sevilla, Pedro; Tejwani, Dimple; Niazi, Masooma; Fuentes, Gilda-Diaz; Venkatram, Sindhaghatta

    2010-01-01

    A 36-year-old male nonsmoker with fever, dyspnea, and cough of 2 weeks' duration presented to the emergency department. He reported left pleuritic chest pain and weight loss for the last 2 months. Chest radiology revealed a left lower lobe mass, a liver lesion, and bony destruction of right sacrum and ribs. Flexible bronchoscopy (FB) revealed an endobronchial (EB) tumorous lesion with cheesy material occluding the left lower lobe. Biopsies and cultures of the lung and rib lesions supported the diagnosis of tuberculosis (TB). Antituberculous therapy was started with rapid clinical improvement. A follow-up FB revealed partial resolution of the EB lesion. EBTB is a rare finding in the developed countries and the association with multiple skeletal and liver lesions is extremely rare. An EB lesion with skeletal lesions usually suggests malignancy or infectious diseases such as EB actinomycosis and fungal infections. The incidence of EBTB varies based on the population reported and has been described in children and young adults. Now, with an increase in international traveling and globalization, it is important for clinicians to include EBTB as a part of the differential diagnosis in patients presenting with EB lesions with or without associated systemic involvement. Early diagnosis and treatment could decrease the morbidity and potential development of bronchial stenosis associated with the disease. FB is highly recommended to identify those patients with poor prognosis who need close monitoring and bronchoscopic follow-up. PMID:23168663

  16. The "Double-Pulley" Technique for Arthroscopic Fixation of Partial Articular-Side Bony Avulsion of the Supraspinatus Tendon: A Rare Case of Bony PASTA Lesion.

    Science.gov (United States)

    Murena, Luigi; Canton, Gianluca; Falvo, Daniele A; Genovese, Eugenio A; Surace, Michele F; Cherubino, Paolo

    2013-02-01

    We report the use of the double-pulley technique for arthroscopic fixation of the bony PASTA (partial articular surface tendon avulsion) lesion. Arthroscopic examination documented a 15-mm-long and 8-mm-wide comminuted bony avulsion with 2 main fragments. Two double-loaded suture anchors were placed with a transtendinous technique at the anterior and posterior edges of the lesion respecting the tendon insertion to the avulsed fragment. The medial sutures were retrieved through the intact supraspinatus tendon medially to the fracture. The sutures were initially coupled in a double-pulley configuration generating 2 sutures oriented from anterior to posterior; then a simple suture for each anchor oriented from medial to lateral was obtained. At the end of the procedure, the adequacy of reduction and stability of the fragments were confirmed. At 2 months from surgery, radiographic healing of the fracture was noted and integrity of the supraspinatus tendon insertion to the footprint was confirmed by arthro-magnetic resonance imaging, with full recovery of daily activities and complete active range of motion confirmed at 6 and 12 months. The double-pulley technique allows optimal reduction of bony fragments and reconstruction of normal footprint anatomy even in comminuted fractures. Moreover, it creates a waterproof reduction of the fragments, protecting the fracture site from synovial fluid. PMID:23767005

  17. The “Double-Pulley” Technique for Arthroscopic Fixation of Partial Articular-Side Bony Avulsion of the Supraspinatus Tendon: A Rare Case of Bony PASTA Lesion

    Science.gov (United States)

    Murena, Luigi; Canton, Gianluca; Falvo, Daniele A.; Genovese, Eugenio A.; Surace, Michele F.; Cherubino, Paolo

    2012-01-01

    We report the use of the double-pulley technique for arthroscopic fixation of the bony PASTA (partial articular surface tendon avulsion) lesion. Arthroscopic examination documented a 15-mm-long and 8-mm-wide comminuted bony avulsion with 2 main fragments. Two double-loaded suture anchors were placed with a transtendinous technique at the anterior and posterior edges of the lesion respecting the tendon insertion to the avulsed fragment. The medial sutures were retrieved through the intact supraspinatus tendon medially to the fracture. The sutures were initially coupled in a double-pulley configuration generating 2 sutures oriented from anterior to posterior; then a simple suture for each anchor oriented from medial to lateral was obtained. At the end of the procedure, the adequacy of reduction and stability of the fragments were confirmed. At 2 months from surgery, radiographic healing of the fracture was noted and integrity of the supraspinatus tendon insertion to the footprint was confirmed by arthro–magnetic resonance imaging, with full recovery of daily activities and complete active range of motion confirmed at 6 and 12 months. The double-pulley technique allows optimal reduction of bony fragments and reconstruction of normal footprint anatomy even in comminuted fractures. Moreover, it creates a waterproof reduction of the fragments, protecting the fracture site from synovial fluid. PMID:23767005

  18. Arthroscopic three-point double-row repair for acute bony Bankart lesions.

    Science.gov (United States)

    Kim, Kyung Cheon; Rhee, Kwang Jin; Shin, Hyun Dae

    2009-01-01

    After mobilizing anteroinferior osseous Bankart lesion from the glenoid neck, a suture anchor loaded with differently colored non-absorbable braided sutures is placed on the medial edge in the glenoid neck along the rim fracture through the anterior-inferior trans-subscapularis tendon portal. Two same-colored suture limbs on the anchor are then pulled through the labrum using PDS suture shuttling simultaneously. These steps are repeated for the others suture limbs. The two same-color suture limbs located inferiorly are retrieved using the trans-subscapularis tendon portal. Both suture strands are threaded through the eyelet of a PushLock anchor on the distal end of the driver. The anchor is advanced into the pilot hole completely. These steps are repeated for a second anchor at the upper edge of the fracture in the glenoid rim using the anterior portal. This technique confers effective, firm fixation of the bony Bankart lesion by three-point fixation without the suture material crossing the glenoid cavity. PMID:18998108

  19. CT findings in diffuse skeletal sclerotic hemangiomatosis: a difficult diagnosis

    International Nuclear Information System (INIS)

    The CT findings in an unusual case of diffuse skeletal nonvisceral hemangiomatosis with radiologic appearance of purely sclerotic lesions are described. To our knowledge, only two cases of diffuse skeletal nonvisceral hemangiomatosis with purely sclerotic lesions and splenic involvement have been reported in the radiologic literature. Our case is the first description of this benign form of skeletal hemangiomatosis with purely sclerotic lesions and without splenic involvement. (orig.)

  20. The bony partial articular surface tendon avulsion lesion: an arthroscopic technique for fixation of the partially avulsed greater tuberosity fracture.

    Science.gov (United States)

    Bhatia, Deepak N; de Beer, Joe F; van Rooyen, Karin S

    2007-07-01

    The partial articular surface tendon avulsion (PASTA) is a common lesion that involves the supraspinatus tendon in most cases. We present an arthroscopic fixation technique for a previously undescribed lesion that may be considered a variant of the PASTA. The lesion involves a partial avulsion of the greater tuberosity with an intact deep insertion of the supraspinatus tendon into the fractured bone fragment and an intact superficial insertion of the supraspinatus into the unavulsed lateral aspect of the greater tuberosity: a "bony PASTA" lesion. The surgical technique involves the use of a 70 degree arthroscope to provide an "end-on" view of the pathology. A superior-medial transmuscular portal is used for anchor insertion and suture management; the portal avoids damage to the intact tendinous insertion of the supraspinatus, which can occur during transtendon anchor/screw insertion. Abduction of the arm to 50 degrees, after creation of the portal and passage of the cannula, permits an optimal "deadman" angle of anchor placement. An angled suture grasper is used to retrieve the 4 suture strands from the double-loaded suture anchor through the intact superficial and deep supraspinatus tendon fibers along the length of the fracture; these are tied as 2 mattress sutures over the tendon fibers in the subacromial space by use of sliding-locking knots. Adequacy of reduction is confirmed by intra-articular arthroscopic observation during movement of the extremity through its complete range of motion. PMID:17637417

  1. Sclerotization of mosquito cuticle.

    Science.gov (United States)

    Sugumaran, M; Semensi, V

    1987-02-15

    The mode of sclerotization of Aedes aegypti pupal and adult cuticle was examined by employing biochemical and radioactive techniques. During larval-pupal metamorphosis, tyrosine is converted to tanning precursors and is incorporated into aryl-amino adducts and beta-crosslinks. The major hydrolysis product of beta-crosslinks in pupal cases is identified to be arterenone. Examination of tanning modes in five different mosquito species shows that the ratio of quinone to beta-sclerotization not only differs within the life stages of the insects, but also differs between species. PMID:3817100

  2. Multiple bony lesions other than femoral heads on {sup 99m}Tc-MDP bone scan in patients with avascular necrosis of the femoral head

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yun Young; Yang, Seoung Oh; Moon, Dae Hyuk; Ryu, Jin Sook; Weon, Young Cheol; Shin, Myung Jin; Lee, Soo Ho; Lee, Hee Kyung [Asan Medical Center, Ulsan Univ. College of Medicine, Ulsan (Korea, Republic of); Chun, Hae Kyung [St. Francisco Hospital, Seoul (Korea, Republic of)

    1997-03-01

    To evaluate the clinical significance of the multiple increased uptake lesions other than in femoral heads as seen on whole body bone scan in patients with avascular necrosis of femoral heads. One hundred and seventy three patients with clinical diagnosis of avascular necrosis of the emoral head underwent a bone scan using Tc-99m MDP. Increased uptake lesions other than in femoral heads were evaluated, including frequency and common sites of in volvement, and correlated with clinical information and plain radiographic findings. Two hundred patients without AVN, who had undergone a bone scan, were included as a control group. Increased uptake lesions in extrafemoral head locations were found in 36 of 173 patients(20.8%); the location of 79 lesions was other than the femoral head. This result is statistically different from patients without avascular necrosis of femoral head(p<0.0001). The most common site of involvement was the knee joint area(62.5%). Other lesions were located in the mid-shafts of the long bones of the lower extremities, calcaneus, proximal humerus, etc., in order of decreasing frequency. Plain radiographs of 17 lesions were nonspecific, except for three lesions showing definite changes associated with avascular necrosis. The risk factors included alcoholism, the prolonged use of steroids, renal transplantation, herbal medication and working as a working as deep-sea diver. Most patients did not complain of pain, except for two with irreversible osteonecrotic changes as seen on plain radiograph. in patients with avascular necrosis of the femur, increased uptake lesions other than in the femoral head as seen on bone scan, may represent the early stage of osteonecrosis, which shows a characteristic appearance on bone scan. In order to aveid possible misdiagnoses of multiple extrafemoral lesions as bony metastasis or traumatic lesions, in patients with avascular necrosis of the femur these should be carefully evaluated.

  3. Multiple bony lesions other than femoral heads on 99mTc-MDP bone scan in patients with avascular necrosis of the femoral head

    International Nuclear Information System (INIS)

    To evaluate the clinical significance of the multiple increased uptake lesions other than in femoral heads as seen on whole body bone scan in patients with avascular necrosis of femoral heads. One hundred and seventy three patients with clinical diagnosis of avascular necrosis of the emoral head underwent a bone scan using Tc-99m MDP. Increased uptake lesions other than in femoral heads were evaluated, including frequency and common sites of in volvement, and correlated with clinical information and plain radiographic findings. Two hundred patients without AVN, who had undergone a bone scan, were included as a control group. Increased uptake lesions in extrafemoral head locations were found in 36 of 173 patients(20.8%;the location of 79 lesions was other than the femoral head, This result is statistically different from patients without avascular necrosis of femoral head(p<0.0001). The most common site of involvement was the knee joint area(62.5%). Other lesions were located in the mid-shafts of the long bones of the lower extremities, calcaneus, proximal humerus, etc., in order of decreasing frequency. Plain radiographs of 17 lesions were nonspecific, except for three lesions showing definite changes associated with avascular necrosis. The risk factors included alcoholism, the prolonged use of steroids, renal transplantation, herbal medication and working as a working as deep-sea diver. Most patients did not complain of pain, except for two with irreversible osteonec except for two with irreversible osteonecrotic changes as seen on plain radiograph. in patients with avascular necrosis of the femur, increased uptake lesions other than in the femoral head as seen on bone scan, may represent the early stage of osteonecrosis, which shows a characteristic appearance on bone scan. In order to aveid possible misdiagnoses of multiple extrafemoral lesions as bony metastasis or traumatic lesions, in patients with avascular necrosis of the femur these should be carefully evaluated

  4. Localized sclerotic bone response demonstrated reduced nanomechanical creep properties.

    Science.gov (United States)

    Chen, Xiuli; Goh, James Cho Hong; Teoh, Swee Hin; De, Shamal Das; Soong, Richie; Lee, Taeyong

    2013-01-01

    Sclerosis (tissue hardening) development is a common occurrence in slow growing or benign osteolytic lesions. However, there is lack of knowledge on the mechanical and material property changes associated with sclerotic bone response. The immune system is postulated to play a relevant role in evoking sclerotic bone responses. In this study, localized sclerotic response in an immunocompetent model of Walker 256 breast carcinoma in SD rats showed an apparent increase in new reactive bone formation. Sclerotic rat femurs had significant increases in bone mineral density (BMD), bone mineral content (BMC), bone volume fraction (BV/TV), bone surface density (BS/TV), trabecular number (Tb.N) and a significant decrease in trabecular separation (Tb.Sp) and structural model index (SMI) as compared to control rat femurs. Significantly reduced creep responses (increased ?) were observed for both trabecular and cortical bone in sclerotic bones while no significant difference was observed in elastic modulus (E) and hardness (H) values. Therefore, we conclude that viscoelastic creep property using nanoindentation would serve as a more sensitive indicator of localized bone modeling than elastic properties. Moreover, reduced viscoelasticity can contribute towards increased microcrack propagation and therefore reduced toughness. Since significant positive correlations between elastic properties (E) and (H) with viscosity (?) were also observed, our results indicate that sclerotic response of bone metastasis would cause reduced toughness (increased ?) with stiffening of material (increased E and H). PMID:23127639

  5. Multifocal sclerotic BCG spondylitis in a 13-year-old girl

    International Nuclear Information System (INIS)

    A case is reported of multifocal BCG osteomyelitis in a 13-year-old girl. The lesions in the skull, ribs and in several vertebrae were mainly sclerotic and healed with antituberculotic therapy. The case is unusual because of the late onset, sclerotic changes, and involvement of the spine. (orig.)

  6. Sclerotic variant of lymphangiomatosis of bone: imaging findings at diagnosis and long-term follow-up

    International Nuclear Information System (INIS)

    Lymphangiomatosis is an extremely rare congenital disorder affecting visceral organs and/or the skeletal system. In bone is is usually characterized by multiple lytic lesions with a lacelike pattern and sclerotic margins of various thickness. In this case report we demonstrate the rare sclerotic variant of lymphangiomatosis. We report the development of predominantly sclerotic lesions at different sites by serial radiographs with a long-term follow-up, and show the MRI findings of lymphangiomatosis of the spine. (orig.)

  7. Insect cuticular sclerotization: a review.

    Science.gov (United States)

    Andersen, Svend Olav

    2010-03-01

    Different regions of an insect cuticle have different mechanical properties, partly due to different degrees of stabilization and hardening occurring during the process of sclerotization, whereby phenolic material is incorporated into the cuticular proteins. Our understanding of the chemistry of cuticular sclerotization has increased considerably since Mark Pryor in 1940 suggested that enzymatically generated ortho-quinones react with free amino groups, thereby crosslinking the cuticular proteins. The results obtained since then have confirmed the essential features of Pryor's suggestion, and the many observations and experiments, which have been obtained, have led to a detailed and rather complex picture of the sclerotization process, as described in this review. However, many important questions still remain unanswered, especially regarding the precise regional and temporal regulation of the various steps in the process. PMID:19932179

  8. Destructive lesion of vertebral body: CT findings and differential diagnosis of inflammation and malignancy

    International Nuclear Information System (INIS)

    The CT findings and their differential points were evaluated by reviewing the CT scans of 47 patients with destructive lesions of vertebral bodies which included tuberculous spondylitis(23), pyogenic infection(9), syphilitic spondylitis(1) and malignant lesion(14). Twenty-one (91.3%) of 23 patients with tuberculous spondylitis showed mixed osteolytic and osteosclerotic patterns of bony destruction. Six(66.7%) of 9 patients with pyogenic infection and 10(71.4%) of 14 malignant lesions showed osteolytic pattern of bony destruction. Thrity(90.9%) of 33 infectious lesions including pyogenic infection and tuberculous spondylitis involved intervertebral disc, while the involvement of intervertebral disc was not found in malignant lesion. The Swiss cheese appearance of bony destruction was commonly seen in tuberculous spondylitis, but pyogenic infections and malignant lesions more commonly revealed geographic or moth-eaten appearance. The sequestral pattern and sclerotic rims in and around bony destruction were mainly seen in tuberculous spondylitis, and they were thought to be specific findings in tuberculous spondylitis. CT of the spine appears to offer the detailed findings of vertebral body destruction and may be a useful adjunct in differentiation between tuberculous spondylitis, pyogenic infections and malignant lesions of the spine

  9. Reduced Antigenicity of Type I Collagen and Proteoglycans in Sclerotic Dentin

    OpenAIRE

    Suppa, P.; Ruggeri, A.; Tay, F. R.; Prati, C.; Biasotto, M.; Falconi, M.; Pashley, D. H.; Breschi, L.

    2006-01-01

    Antigenic alterations to the dentin organic matrix may be detected by an immunohistochemical approach. We hypothesized that alterations in the antigenicity of type I collagen and proteoglycans occur in sclerotic dentin under caries lesions. Transverse sections were prepared from carious teeth in the sclerotic zone and normal hard dentin. A double-immunolabeling technique was performed on these sections, with anti-type I collagen and anti-chondroitin 4/6 sulfate monoclonal primary antibodies. ...

  10. Sclerotic variant of lymphangiomatosis of bone: imaging findings at diagnosis and long-term follow-up

    Energy Technology Data Exchange (ETDEWEB)

    Forstner, R. [Department of Radiology, Salzburg (Austria); Datz, C. [Department of Medicine, Landeskrankenanstalten Salzburg (Austria); Dietze, O. [Department of Pathology, Landeskrankenanstalten Salzburg (Austria); Rettenbacher, L. [Department of Nuclear Medicine, Landeskrankenanstalten Salzburg (Austria)

    1998-08-01

    Lymphangiomatosis is an extremely rare congenital disorder affecting visceral organs and/or the skeletal system. In bone is is usually characterized by multiple lytic lesions with a lacelike pattern and sclerotic margins of various thickness. In this case report we demonstrate the rare sclerotic variant of lymphangiomatosis. We report the development of predominantly sclerotic lesions at different sites by serial radiographs with a long-term follow-up, and show the MRI findings of lymphangiomatosis of the spine. (orig.) With 4 figs., 12 refs.

  11. Bony sequestrum: A radiologic review

    Energy Technology Data Exchange (ETDEWEB)

    Jennin, Felicie; Bousson, Valerie; Parlier, Caroline; Jomaah, Nabil; Khanine, Vanessa; Laredo, Jean-Denis [Lariboisiere Hospital, Department of Radiology, Paris (France)

    2011-08-15

    According to a pathological definition, a bony sequestrum is defined as a piece of devitalized bone that has been separated from the surrounding bone during the process of necrosis. However, the radiological definition of a sequestrum is different and refers to an image of calcification visible within a lucent lesion, completely separated from the surrounding bone, without referring to the vascular status and histological nature of the calcified tissue. The term ''button sequestrum'' has been used in calvarial lesions. The prototype conditions that may present with a bony sequestrum are osteomyelitis and skeletal tuberculosis. Other conditions such as radiation necrosis, eosinophilic granuloma, metastatic carcinoma, primary lymphoma of bone, aggressive fibrous tumors may also manifest as osteolytic lesions containing a sequestrum. In addition, some primary bone tumors produce a matrix that may mineralize and sometimes simulate a bone sequestrum. These include osteoid tumors (osteoid osteoma, osteoblastoma), cartilaginous tumors (chondroma and chondroblastoma), lipomatous tumors (lipoma), and benign fibrous tumors (fibromyxoma, myxoma, and desmoplastic fibroma). Therefore, various conditions may present at imaging as a small area of osteolysis containing central calcifications. However, a careful analysis of the sequestrum as well as the associated clinical and radiological findings often enables to point toward a limited number of conditions. (orig.)

  12. Sclerotic multiple myeloma with an unusual sunburst periosteal reaction occurring in the sternum.

    Science.gov (United States)

    Li, Yuqing; Wu, Wenjuan; Zhang, Zekun; Ding, Yang; Latif, Mahrukh

    2015-05-01

    Multiple myeloma is a disseminated neoplastic monoclonal gammopathy that usually affects the skull, clavicle, rib, pelvis, spinal column, and proximal portions of the humerus and femur. The initial manifestation of multiple myeloma in the sternum is rare. The classic radiological presentations of multiple myeloma are multiple "punched-out" areas of bone destruction, expansile lytic lesions, and generalized osteoporosis. Primary sclerotic presentation is rare and occurs in only 3 % of cases. A sclerotic multiple myeloma with a sunburst periosteal reaction occurring in the sternum has not been reported in the English literature. We report a case of sclerotic multiple myeloma of a 49-year-old woman. In the sternum, the lesion displayed extensive sclerosis mixed with mottled lytic areas with a sunburst periosteal reaction occurring in the periphery, which radiologically mimicked an osteosarcoma. Multiple focal areas of sclerosis were also found in the right clavicle, pelvis, multiple ribs, and vertebrae. PMID:25351419

  13. CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS

    Directory of Open Access Journals (Sweden)

    Taeko Nakamura-Wakatsuki

    2013-10-01

    Full Text Available Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fingers have not been reported to date. Mucin deposition in the sclerotic skin may be a predisposing factor in the induction of myxoid cyst on the scleroderma finger in our patient.

  14. Sclerotic bodies beyond nephrogenic systemic fibrosis.

    Science.gov (United States)

    Bhawan, Jag; Perez-Chua, Tanya A; Goldberg, Lynne

    2013-09-01

    Sclerotic bodies are round to oval structures made up of collagen with entrapped elastic fibers, which may be sometimes ossified. These bodies may be found in skin biopsies from patients with nephrogenic systemic fibrosis (NSF), a disease linked to the use of gadolinium in radiologic procedures and chronic renal failure. Sclerotic bodies have not been reported in other diseases. Herein, we report sclerotic bodies as an incidental finding in a re-excision specimen of a squamous cell carcinoma (SCC) from the forearm of an 85-year-old man with chronic renal failure. The patient had had multiple SCC removed over time. Additional clinical history revealed patient having received gadolinium in 2003 and 2004, preceding his dialysis that began in 2009. All of his excision specimens revealed sclerotic bodies in 20 of 30 specimens from 2008. None of the 26 re-excision specimens prior to gadolinium exposure had these bodies. Our findings suggest that sclerotic bodies are the result of gadolinium exposure in patients with chronic renal insufficiency. Because the bodies were found near the re-excision scar, it may be that gadolinium or its metabolites activate fibroblasts in the setting of wound healing. The reasons why this patient did not develop NSF are unclear. PMID:23808625

  15. Arthroscopic Bony Bankart Fixation Using a Modified Sugaya Technique

    OpenAIRE

    Gupta, Anil K.; Mccormick, Frank M.; Abrams, Geoffrey D.; Harris, Joshua D.; Bach, Bernard R.; Romeo, Anthony A.; Verma, Nikhil N.

    2013-01-01

    Arthroscopic fixation of bony Bankart lesions in the setting of anterior shoulder instability has had successful long-term results. Key factors such as patient positioning, portal placement, visualization, mobilization of bony/soft tissues, and anatomic reduction and fixation are crucial to yield such results. We present a modified Sugaya technique that is reproducible and based on such key principles. This technique facilitates ease of anchor and suture placement to allow for anatomic reduct...

  16. Sclerotic changes of the manubrium sterni

    Energy Technology Data Exchange (ETDEWEB)

    Jurik, A.G.; Graudal, H.; De Carvalho, A.

    1985-03-01

    Six females with nearly identical sclerotic and hyperostotic changes of the manubrium sterni are reported. Malignancies, bacterial inflammatory processes, and Paget disease, which were first suspected, could be excluded. The youngest patients also had sclerotic changes of other bones, including the lumbar spine, the pubic bone, and the clavicle, and may be classified as having ''chronic recurrent multifocal osteomyelitis'' (CRMO). The two oldest patients had ossification of the costoclavicular ligament(s) and may be classified as having ''inter-sterno-costo-clavicular ossification'' (ISCCO). One had only hyperostotic and sclerotic changes as seen in ''sterno-costo-clavicular hyperostosis'' (SCCH). The pathogenesis of these uncommon diseases is unknown, but they are all frequently associated with pustulosis palmoplantaris and have similar clinical courses and laboratory abnormalities. None of the present patients had HLA-B/sub 27/. The similarity of the radiological abnormalities of the manubrium sterni suggests that the diseases themselves may be similar, but with different courses depending on age, CRMO being present in children and young adults and ISCCO or SCCH in older adults.

  17. Sclerotic changes of the manubrium sterni

    International Nuclear Information System (INIS)

    Six females with nearly identical sclerotic and hyperostotic changes of the manubrium sterni are reported. Malignancies, bacterial inflammatory processes, and Paget disease, which were first suspected, could be excluded. The youngest patients also had sclerotic changes of other bones, including the lumbar spine, the pubic bone, and the clavicle, and may be classified as having ''chronic recurrent multifocal osteomyelitis'' (CRMO). The two oldest patients had ossification of the costoclavicular ligament(s) and may be classified as having ''inter-sterno-costo-clavicular ossification'' (ISCCO). One had only hyperostotic and sclerotic changes as seen in ''sterno-costo-clavicular hyperostosis'' (SCCH). The pathogenesis of these uncommon diseases is unknown, but they are all frequently associated with pustulosis palmoplantaris and have similar clinical courses and laboratory abnormalities. None of the present patients had HLA-B27. The similarity of the radiological abnormalities of the manubrium sterni suggests that the diseases themselves may be similar, but with different courses depending on age, CRMO being present in children and young adults and ISCCO or SCCH in older adults. (orig.)

  18. Radiographic evaluation of therapeutic response in bony metastases of breast cancer

    International Nuclear Information System (INIS)

    Response to chemotherapy was evaluated in 50 previously untreated patients with bony metastases of breast cancer. Lytic metstates respond in a definite sequence: sclerotic rim, filling-in, uniformly blastic, uniform fading. Increase in size of lytic areas or destruction in previously responding areas signals worsening. Mixed metastases are considered as beginning with a sclerotic rim. Response is otherwise similar. Particular attention is paid to the lytic areas. Blastic metastases are considered as beginning at the uniformly blastic stage. Progression is marked by a volumetric increase in blastic change or destruction in blastic regions. Change occurs slowly. Review of multiple studies is often necessary to reach the correct conclusion and clinical history is necessary. (orig.)

  19. Detection of sclerotic bone metastases in the spine using watershed algorithm and graph cut

    Science.gov (United States)

    Wiese, Tatjana; Yao, Jianhua; Burns, Joseph E.; Summers, Ronald M.

    2012-03-01

    The early detection of bone metastases is important for determining the prognosis and treatment of a patient. We developed a CAD system which detects sclerotic bone metastases in the spine on CT images. After the spine is segmented from the image, a watershed algorithm detects lesion candidates. The over-segmentation problem of the watershed algorithm is addressed by the novel incorporation of a graph-cuts driven merger. 30 quantitative features for each detection are computed to train a support vector machine (SVM) classifier. The classifier was trained on 12 clinical cases and tested on 10 independent clinical cases. Ground truth lesions were manually segmented by an expert. The system prior to classification detected 87% (72/83) of the manually segmented lesions with volume greater than 300 mm3. On the independent test set, the sensitivity was 71.2% (95% confidence interval (63.1%, 77.3%)) with 8.8 false positives per case.

  20. Osteosclerotic lesions in patients treated with gefitinib for lung adenocarcinomas: a sign of favorable therapeutic response

    International Nuclear Information System (INIS)

    To assess the frequency of osteosclerotic changes on CT that appeared after treatment with gefitinib in patients with lung adenocarcinoma and the relationship between the osteosclerotic changes and the response to the therapy. Our study included 41 patients with lung adenocarcinoma who underwent chest CT both before (CTpre) and after (CTpost) starting treatment with gefitinib. The presence or absence of bone metastases was assessed on the CTpre, and the interval bony change after the therapy was classified as lytic, sclerotic, or no changes on the CTpost. The relationship between treatment results of primary lung cancer and interval bony changes was evaluated. Osteosclerotic lesions were identified in 11 patients (27%) on CTpost; in 6 of 11 patients osteosclerotic lesions newly appeared where the CTpre showed no bone metastasis before the gefitinib therapy. There were significant differences in the therapeutic response of the primary cancers (P < 0.001) and in the survival rate (P < 0.01) in patients with osteosclerotic changes versus those without osteosclerotic changes. Osteosclerotic changes on CT, observed after gefitinib treatment in patients with lung adenocarcinomas, may be an indicator of a good therapeutic response. (orig.)

  1. Osteosclerotic lesions in patients treated with gefitinib for lung adenocarcinomas: a sign of favorable therapeutic response

    Energy Technology Data Exchange (ETDEWEB)

    Yamashita, Yoshiko; Aoki, Takatoshi; Korogi, Yukunori [University of Occupational and Environmental Health, School of Medicine, Department of Radiology, Kitakyushu (Japan); Hanagiri, Takeshi; Uramoto, Hidetaka [University of Occupational and Environmental Health, School of Medicine, Second Department of Surgery, Kitakyushu (Japan); Yoshii, Chiharu; Mukae, Hiroshi [University of Occupational and Environmental Health, School of Medicine, Department of Respiratory Disease, Kitakyushu (Japan)

    2012-04-15

    To assess the frequency of osteosclerotic changes on CT that appeared after treatment with gefitinib in patients with lung adenocarcinoma and the relationship between the osteosclerotic changes and the response to the therapy. Our study included 41 patients with lung adenocarcinoma who underwent chest CT both before (CTpre) and after (CTpost) starting treatment with gefitinib. The presence or absence of bone metastases was assessed on the CTpre, and the interval bony change after the therapy was classified as lytic, sclerotic, or no changes on the CTpost. The relationship between treatment results of primary lung cancer and interval bony changes was evaluated. Osteosclerotic lesions were identified in 11 patients (27%) on CTpost; in 6 of 11 patients osteosclerotic lesions newly appeared where the CTpre showed no bone metastasis before the gefitinib therapy. There were significant differences in the therapeutic response of the primary cancers (P < 0.001) and in the survival rate (P < 0.01) in patients with osteosclerotic changes versus those without osteosclerotic changes. Osteosclerotic changes on CT, observed after gefitinib treatment in patients with lung adenocarcinomas, may be an indicator of a good therapeutic response. (orig.)

  2. Monte Carlo Simulation of Bony Heterogeneity Effects on Dose Profile for Small Irradiation Field in Radiotherapy

    OpenAIRE

    Cardoso, Simone C.; Alves, Victor Gabriel L.; Da Rosa, Luiz Antonio R.; Campos, Luciana T.; Batista, Delano V. S.; Facure, Alessandro

    2010-01-01

    In the radiotherapy treatment planning of a lesion located in the head region with small field radiation beams, the heterogeneity corrections play an important role. In this work, we investigated the influence of a bony heterogeneity on dose profile inside a soft tissue phantom containing a bony material. PDD curves were obtained by simulation using the Monte Carlo code EGSnrc and employing Eclipse® treatment planning system algorithms (Batho, Modified Batho, Equivalent TAR and Anisotropic A...

  3. Bony ankylosis following thermal and electrical injury

    International Nuclear Information System (INIS)

    Objective. Bony ankylosis has been described following trauma, paralysis, psoriasis, Reiter's syndrome, ankylosing spondylitis, juvenile chronic arthritis and rheumatoid arthritis. Reports of bony ankylosis following thermal and electrical injury are limited.Design and patients. Thirteen cases of burn-related joint ankylosis in four patients are presented.Conclusion. Patients with burns from thermal or electrical injury may develop bony ankylosis among other radiographic manifestations. This bony ankylosis may result either from bridging extra-articular heterotopic ossification with preservation of the underlying joint or from intra-articular fusion due to joint destruction. (orig.)

  4. Bony sclerosis in patients with maxillofacial carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Kurosaki, Yoshihisa; Ebihara, Reiko; Sato, Shiko; Tsunoda, Hiroko; Saida, Yukihisa

    1987-11-01

    CT examinations of the patients with maxillofacial carcinoma were reviewed with special interest in bony sclerosis. Bony sclerosis was observed in seven of 10 patients with maxillary sinus carcinoma. The site of sclerosis included zygoma and pterygoid process. Two of four patients with nasopharyngeal carcinoma invading the parapharyngeal space showed sclerosis of the skull base. High resolution CT with bone display is useful for demonstrating bony sclerosis. The feasibility of using bony sclerosis for determining the stage of the tumor and predicting the clinical course is suggested.

  5. Bony ankylosis following thermal and electrical injury

    Energy Technology Data Exchange (ETDEWEB)

    Balen, P.F.; Helms, C.A. [Dept. of Radiology, Duke University Medical Center, Durham, NC (United States)

    2001-07-01

    Objective. Bony ankylosis has been described following trauma, paralysis, psoriasis, Reiter's syndrome, ankylosing spondylitis, juvenile chronic arthritis and rheumatoid arthritis. Reports of bony ankylosis following thermal and electrical injury are limited.Design and patients. Thirteen cases of burn-related joint ankylosis in four patients are presented.Conclusion. Patients with burns from thermal or electrical injury may develop bony ankylosis among other radiographic manifestations. This bony ankylosis may result either from bridging extra-articular heterotopic ossification with preservation of the underlying joint or from intra-articular fusion due to joint destruction. (orig.)

  6. Endoprosthetic replacement for bony metastases.

    OpenAIRE

    Chan, D.; Carter, S. R.; Grimer, R. J.; Sneath, R. S.

    1992-01-01

    A series of 38 patients with long bone metastases treated at the Birmingham Bone Tumour Treatment Service with resection of the metastatic lesion and replacement of the bone defect with an endoprosthesis was reviewed. The majority of cases had pathological fractures due to a massive destructive lesion. Two-thirds of the patients had a solitary metastasis. Metastases from hypernephroma and breast carcinoma accounted for the majority of cases. All the patients were independently mobile after th...

  7. Detection of bony metastases of androgen-independent prostate cancer by PET-FDG

    International Nuclear Information System (INIS)

    Fourteen F-18 fluorodeoxyglucose (FDG) studies were carried out in 13 patients known to have bony metastases from carcinoma of the prostate. One patient was newly diagnosed. The remaining patients had various types of therapy and were considered hormonally resistant. The average age was 67. All patients had extensive bony metastases shown on the conventional Tc99m-MDP bone scans. Only about 18% of bony lesions apparent on the conventional bone scans showed corresponding increase of FDG uptake. Anatomical correlation was performed by using co-registered images of SPECT and PET in the same area. The positive FDG uptake was not related to the duration of illness, level of PSA, previous therapy, and magnitude of disease involvement. It appears that only a small percentage of bony metastases is associated with increased glycolysis. It is possible that other metabolic processes are more important than glycolysis for providing prostate cancer with a source of energy and nutrients

  8. Post Pelvic Radiotherapy Bony Changes

    Energy Technology Data Exchange (ETDEWEB)

    Huh, Seung Jae [Samsung Medical Center, Seoul (Korea, Republic of)

    2009-03-15

    There has been recent interest in radiation-induced bone injury in clinical conditions, especially for pelvic insufficiency fracture (PIF). A PIF is caused by the effect of normal or physiological stress on bone with demineralization and decreased elastic resistance. Pelvic radiotherapy (RT) can also contribute to the development of a PIF. A PIF has been regarded as a rare complication with the use of megavoltage equipment. However, recent studies have reported the incidence of PIFs as 8.2{approx}20% after pelvic RT in gynecological patients, an incidence that was higher than previously believed. The importance of understanding a PIF lies in the potential for misdiagnosis as a bony metastasis. If patients complain of pelvic pain after whole-pelvis radiation therapy, the presence of a PIF must be considered in the differential diagnosis. The use of multibeam arrangements and conformal RT to reduce the volume and dose of irradiated pelvic bone can be helpful to minimize the risk of fracture. In addition to a PIF, osteonecrosis and avascular necrosis of the femoral head can develop after radiation therapy. Osteoradionecrosis of the pelvic bone is a clinical diagnostic challenge that must be differentiated from an osseous metastasis. A post-radiation bone sarcoma can result as a long-term sequela of pelvic irradiation for uterine cervical cancer.

  9. Sclerotic Rings in Mosasaurs (Squamata: Mosasauridae): Structures and Taxonomic Diversity

    Science.gov (United States)

    Yamashita, Momo; Konishi, Takuya; Sato, Tamaki

    2015-01-01

    Mosasaurs (Squamata: Mosasauridae) were a highly diverse, globally distributed group of aquatic lizards in the Late Cretaceous (98–66 million years ago) that exhibited a high degree of adaptation to life in water. To date, despite their rich fossil record, the anatomy of complete mosasaur sclerotic rings, embedded in the sclera of the eyeball, has not been thoroughly investigated. We here describe and compare sclerotic rings of four mosasaur genera, Tylosaurus, Platecarpus, Clidastes, and Mosasaurus, for the first time. Two specimens of Tylosaurus and Platecarpus share an exact scleral ossicle arrangement, excepting the missing portion in the specimen of Platecarpus. Furthermore, the exact arrangement and the total count of 14 ossicles per ring are shared between Tylosaurus and numerous living terrestrial lizard taxa, pertaining to both Iguania and Scleroglossa. In contrast, two species of Mosasaurus share the identical count of 12 ossicles and the arrangement with each other, while no living lizard taxa share exactly the same arrangement. Such a mosaic distribution of these traits both among squamates globally and among obligatorily aquatic mosasaurs specifically suggests that neither the ossicle count nor their arrangement played major roles in the aquatic adaptation in mosasaur eyes. All the mosasaur sclerotic rings examined consistently exhibit aperture eccentricity and the scleral ossicles with gently convex outer side. Hitherto unknown to any squamate taxa, one specimen of Platecarpus unexpectedly shows a raised, concentric band of roughened surface on the inner surface of the sclerotic ring. It is possible that one or both of these latter features may have related to adaptation towards aquatic vision in mosasaurs, but further quantitative study of extant reptilian clades containing both terrestrial and aquatic taxa is critical and necessary in order to understand possible adaptive significances of such osteological features. PMID:25692667

  10. Anorectal malformations with sacral bony abnormalities.

    OpenAIRE

    Nour, S.; Kumar, D.; Dickson, J. A.

    1989-01-01

    A range of anorectal malformations with sacral bony abnormalities was found in members from three generations of two kindreds. The anorectal anomaly was low in all but one of the patients. Partial sacral agenesis was the main bony defect in one family, and meningomyelocele and spina bifida occulta were noted in the second. The inheritance pattern in these kinships is autosomal dominant. This may be a variant of caudal regression syndrome, which seems to be aetiologically heterogeneous.

  11. Tyrosine hydroxylase is required for cuticle sclerotization and pigmentation in Tribolium castaneum

    OpenAIRE

    Gorman, Maureen J.; Arakane, Yasuyuki

    2010-01-01

    Newly synthesized insect cuticle is soft and pale but becomes stronger (sclerotized) and often darker (pigmented) over several hours or days. The first step in the sclerotization and pigmentation pathways is the hydroxylation of tyrosine to produce 3,4-dihydroxyphenylalanine (DOPA). Tyrosine hydroxylase (TH) is known to catalyze this reaction during pigmentation, but a role for TH in sclerotization has not been documented. The goal of this study was to determine whether TH is required for cut...

  12. Dopamine-Mediated Sclerotization of Regenerated Chitin in Ionic Liquid

    Directory of Open Access Journals (Sweden)

    Dongyeop X. Oh

    2013-09-01

    Full Text Available Chitin is a promising structural material for biomedical applications, due to its many advantageous properties and abundance in nature. However, its usage and development in the biomedical field have been stagnant, because of chitin’s poor mechanical properties in wet conditions and the difficulties in transforming it into an applicable form. To overcome these challenges, we created a novel biomimetic chitin composite. This regenerated chitin, prepared with ionic liquid, showed improved mechanical properties in wet conditions by mimicking insect cuticle and squid beak sclerotization, i.e., catechol-meditated cross-linking. By ionic liquid-based heat treatment, dopamine oxidation produced melanin-like compounds and dopamine-meditated cross-links without any solvent evaporation and oxidant utilization. The dopamine-meditated sclerotization increased the ultimate tensile strength (UTS of the regenerated chitin by 2.52-fold, measured after six weeks of phosphate-buffered saline (PBS submersion. In addition, the linear swelling ratio (LSR of the chitin film was reduced by about 22%. This strategy raises a possibility of using regenerated chitin as an artificial hard tissue in wet conditions.

  13. Solitary sclerotic fibroma of the skin: morphological characterization of the 'plywood-like pattern'.

    Science.gov (United States)

    Nakashima, Keiko; Yamada, Nanako; Adachi, Koji; Yoshida, Yuichi; Yamamoto, Osamu

    2008-10-01

    Sclerotic fibroma is an uncommon skin tumor. Rapini and Golitz reported 11 cases of solitary sclerotic fibromas in patients without Cowden's disease in 1989. We report a case of sclerotic fibroma that presented as an asymptomatic nodule in a 34-year-old Japanese man. Histopathological examination revealed typical features of sclerotic fibroma of the skin. Ultrastructural examination showed that spindle cells with myoid features had proliferated around the vasculature. They had segregated from the perivascular area by leaving the surrounding basal lamina, resulting in their phenotypical change to produce collagen accumulating in a concentrically lamellar fashion. We suggest a possible role of abnormal blood vessels and surrounding specific cells in the development of sclerotic fibroma. PMID:18544068

  14. Bony island within the articular cartilage of the knee in a child: a rare condition for early osteoarthritis

    Directory of Open Access Journals (Sweden)

    Eiji Itoi

    2011-03-01

    Full Text Available Articular cartilage is a specific type of connective tissue composed of hydrated proteoglycans within a matrix of collagen fibrils. In the elderly population, it shows degenerative changes that may results in osteoarthritis. The more severe form of osteoarthritis occasionally demonstrates bone formation within the cartilage, which is designated as a bony protuberance, however, such lesions are rare in children. This report presents the case of a 10-year-old boy with a bony protuberance within the articular cartilage of the knee. The patient initially complained of knee pain and he subsequently developed flexion contracture. Radiological and arthroscopic examinations revealed a bony protuberance in the articular cartilage and degenerative changes of the cartilage above it. He was successfully treated by the removal of the bony protuberance and osteochondral grafting. The bony protuberance may have caused cartilage degradation since the thickness of the cartilage above it was thinner than that around the lesion. The bony protuberance within the articular cartilage formed in the younger population may be a possible cause of osteoarthritis. This case is a noteworthy with regard to the pathogenesis of osteoarthritis.

  15. PrimaryiIntraosseousm meningioma in the orbital bony wall: A case report and review of the literature review

    International Nuclear Information System (INIS)

    Meningiomas arising outside the intracranial compartment are known as extradural meningiomas. Extradural meningiomas are rare conditions, accounting for less than 2% of all meningiomas. Primary intraosseous meningioma is used to describe a subset of extradural meningiomas arising from bone. A 46-year-old woman presented with left exophthalmos. Computed tomography and magnetic resonance images revealed an expansile bony lesion in the orbital lateral wall of the left sphenoid bone. The patient underwent craniotomy for excision of the bony lesion. Pathologic examination revealed an intraosseous meningioma.

  16. Orthodontic tooth movement enhancing bony apposition in alveolar bony defect: a case report

    OpenAIRE

    Hibino, Kyoko; Wong, Ricky Wk

    2009-01-01

    Introduction: Prevalence of complications from orthognathic surgery is relatively low but if it happens it is vital to manage the post complication bony defect appropriately. Case Presentation: This case report describes a 20-year-old gentleman who suffered from a complication from a bimaxillary orthognathic surgery. A bone grafting was carried out to repair the bony defect from the surgery but it was unsuccessful. A non-invasive technique employing the use of very light orthodontic force wit...

  17. Computed tomography assessment of bone lesions in patients with POEMS syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Glazebrook, K.; Johnson, Adam; Leng, S.; Dispenzieri, A. [Mayo Clinic, Rochester, MN (United States); Guerra Bonilla, Francis L. [Hospital Regional Rafael Hernandez, Hematology Division, David, Chiriqui (Panama)

    2014-09-25

    To describe the imaging findings on computed tomography (CT) and skeletal survey (SS) in patients with POEMS syndrome. We retrospectively reviewed, with institutional review board approval, the dysproteinemia database at our institution for patients with new diagnosis of POEMS syndrome between January 1998 and December 2008. Twenty-four patients were identified with PET/CT or CT and had skeletal survey (SS) available for review. Twenty-four patients were included in the study group with median age of 47 years. All CTs demonstrated at least one sclerotic lesion. The most common pattern was multiple small lesions, with 18 patients (75 %) having at least 5 lesions less than 1 cm. The larger lesions had a central lytic component and were FDG avid. SS had a false negative rate of 36 % (8 patients). Serial CT after treatment showed a decrease in size and number of sclerotic lesions in 53 % of cases (13 patients), the majority showing increased sclerosis. Two patients had complete resolution of sclerotic lesions. CT identified sclerotic lesions in all study patients with POEMS syndrome, the majority being less than 1 cm in size, which were not identified radiographically. CT may demonstrate increased sclerosis or even resolution of sclerotic lesions corresponding to treatment response. (orig.)

  18. Computed tomography assessment of bone lesions in patients with POEMS syndrome

    International Nuclear Information System (INIS)

    To describe the imaging findings on computed tomography (CT) and skeletal survey (SS) in patients with POEMS syndrome. We retrospectively reviewed, with institutional review board approval, the dysproteinemia database at our institution for patients with new diagnosis of POEMS syndrome between January 1998 and December 2008. Twenty-four patients were identified with PET/CT or CT and had skeletal survey (SS) available for review. Twenty-four patients were included in the study group with median age of 47 years. All CTs demonstrated at least one sclerotic lesion. The most common pattern was multiple small lesions, with 18 patients (75 %) having at least 5 lesions less than 1 cm. The larger lesions had a central lytic component and were FDG avid. SS had a false negative rate of 36 % (8 patients). Serial CT after treatment showed a decrease in size and number of sclerotic lesions in 53 % of cases (13 patients), the majority showing increased sclerosis. Two patients had complete resolution of sclerotic lesions. CT identified sclerotic lesions in all study patients with POEMS syndrome, the majority being less than 1 cm in size, which were not identified radiographically. CT may demonstrate increased sclerosis or even resolution of sclerotic lesions corresponding to treatment response. (orig.)

  19. 1,2-dehydro-N-beta-alanyldopamine as a new intermediate in insect cuticular sclerotization.

    Science.gov (United States)

    Ricketts, D; Sugumaran, M

    1994-09-01

    Sclerotization of insect cuticle is an extremely important biochemical process for the successful survival of most insects. N-Acetyldopamine and N-beta-alanyldopamine are two widely used sclerotizing precursors. N-Acetyldopamine is converted by phenoloxidase, quinone isomerase, and quinone methide isomerase to generate the reactive intermediates quinone, quinone methide, and quinone methide imine amide for use in quinone tanning, quinone methide sclerotization, and alpha,beta-sclerotization, respectively. N-beta-Alanyldopamine has been claimed to be used only by phenoloxidase and quinone isomerase for quinone tanning and quinone methide sclerotization thereby attributing biochemical diversity to the coloration and strength of different cuticles. However, we demonstrate here that cuticular enzymes isolated from the larvae of Calliphora possess the capacity to generate 1,2-dehydro-N-beta-alanyldopamine from N-beta-alanyldopamine. Chemical synthesis of 1,2-dehydro-N-beta-alanyldopamine and its further oxidation are reported for the first time. Comparative biochemical studies confirm that both the sclerotizing precursors, N-acetyldopamine and N-beta-alanyldopamine, are used by all three different mechanisms of the unified theory of sclerotization. PMID:8071347

  20. [Ethmoidal mucocele after transpalpebral bony orbital decompression].

    Science.gov (United States)

    Gire, J; Facon, F; Guigou, S; Fauquier, S; Malet, T

    2012-10-01

    We report a case of a late ethmoidal mucocele occurring after transpalpebral bony orbital decompression. A 39-year-old man presented with a recurrence of a right-sided proptosis without signs of orbital inflammation. The patient had undergone bilateral transpalpebral bony orbital decompression for dysthyroid orbitopathy 2 years prior. Orbital CT scan showed a large mucocele in the supero-lateral right ethmoidal sinus with lateral extension to the medial rectus. The patient was therefore referred to an ear, nose and throat (ENT) surgeon, who performed an anterior ethmoidectomy with marsupialization and drainage of the mucocele via an endoscopic approach. A complete postoperative resolution of proptosis was observed without recurrence of the mucocele to date, approximately 6 months postoperative. Sinus complications occurring after orbital decompression may include sinusitis, hematoma, imploding antrum syndrome and mucoceles. Recurrent proptosis secondary to an ethmoidal mucocele is a rare event after bony orbital decompression surgery, with only two cases reported in the international literature. Management requires ophthalmologic diagnosis and collaboration between the ophthalmologist and otorhinolaryngologist. PMID:22975269

  1. Cutaneous mucinosis associated with multiple frozen joints and bony heterotopic deposits around the hips.

    Science.gov (United States)

    Dufour, J P; Lachapelle, J M; Nagant de Deuxchaisnes, C; Devogelaer, J P; Noel, H; Maldague, B

    1986-06-01

    A 43-year-old man suffered from migrating then additive arthralgias associated with macroscopic and microscopic cutaneous lesions compatible at first sight with reticular erythematous mucinosis. After nine months, the cutaneous picture evolved into a papular mucinosis. The patient developed "multiple frozen joints" with heterotopic bony deposits around the hips. To our knowledge, such articular problems have not yet been described in this condition. Severe systemic complications prompted the authors to treat the patient with plasma exchange and melphalan. PMID:3731720

  2. Quantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study.

    OpenAIRE

    Messiou, C.; Collins, Dj; Morgan, Va; Robson, Md; Debono, Js; Bydder, Gm; Desouza, Nm

    2010-01-01

    INTRODUCTION: Ultra Short TE MRI allows signal to be detected from tissues with a very short T2.The aims of this study were to optimize a 2D UTE MRI sequence for imaging and quantification of sclerotic bone metastases, establish T2* values of sclerotic components and investigate the feasibility of using the method to assess changes in T2* of sclerotic metastases and their relation to attenuation values in patients on treatment. METHODS: Twenty-two subjects were recruited in 3 cohorts. Cohort ...

  3. Tyrosine hydroxylase is required for cuticle sclerotization and pigmentation in Tribolium castaneum.

    Science.gov (United States)

    Gorman, Maureen J; Arakane, Yasuyuki

    2010-03-01

    Newly synthesized insect cuticle is soft and pale but becomes stronger (sclerotized) and often darker (pigmented) over several hours or days. The first step in the sclerotization and pigmentation pathways is the hydroxylation of tyrosine to produce 3,4-dihydroxyphenylalanine (DOPA). Tyrosine hydroxylase (TH) is known to catalyze this reaction during pigmentation, but a role for TH in sclerotization has not been documented. The goal of this study was to determine whether TH is required for cuticle sclerotization in the red flour beetle, Tribolium castaneum. We used quantitative RT-PCR to verify that TH expression occurs at the time of cuticle tanning and immunohistochemistry to confirm that TH is expressed in the epithelial cells underlying sclerotized cuticle. In addition, we found that a reduction in TH function (mediated by RNA interference) resulted in a decrease in cuticle pigmentation and a decrease in the hardness of both pigmented and colorless cuticle. These results demonstrate a requirement for TH in sclerotization as well as brown pigmentation of insect cuticle. PMID:20080183

  4. Quantitative determination of catecholic degradation products from insect sclerotized cuticles.

    Science.gov (United States)

    Andersen, Svend Olav

    2008-09-01

    Acid hydrolysates of cuticle from various insect species were quantitatively analyzed for five catecholic amino acid adducts. Four of the adducts are ketocatechols; in three of them the amino acid moiety, either lysine, glycine or beta-alanine, is connected via its amino group to the alpha-carbon atom of 3,4-dihydroxyacetophenone, in the fourth a tyrosine residue is connected to the same position via its phenolic group. The fifth adduct contains histidine linked via its imidazole-ring to the beta-position of the dopamine sidechain. The three ketocatecholic adducts containing alpha-amino acids were obtained in significant yields from adult cuticles of the locust Schistocerca gregaria, the cockroaches Blaberus craniifer and Periplaneta americana, and the beetles Pachynoda sinuata and Tenebrio molitor, but only in trace amounts from larval and pupal cuticles of T. molitor, pupal cuticles of the moths Manduca sexta and Hyalophora cecropia, and puparia of the blowfly Calliphora vicina. The beta-alanine-containing ketocatechol was not obtained from cuticle of locusts and T. molitor larvae and pupae, but it was present in the hydrolysates of the other cuticles. The beta-histidine-dopamine adduct was obtained from all the cuticles, the highest yield was obtained from adult P. sinuata and the lowest yield was from adult S. gregaria. The beta-histidine-dopamine adduct is derived from the product formed by reaction of p-quinone methides of N-acetyldopamine (NADA) or N-beta-alanyldopamine (NBAD) with histidine residues in the cuticular proteins. The ketocatecholic adducts are assumed to be degradation products of crosslinks formed when oxidized dehydro-NADA reacts with the cuticular proteins. The insect species investigated appear to use both pathways for sclerotization, but to widely differing extents; the dehydro-NADA pathway dominates in cuticles which are exposed to strong deforming forces, such as those of adult locusts and cockroaches, and the p-quinone methide pathway dominates in cuticle of lepidopteran pupae and blowfly puparia, which are not exposed to strong mechanical forces but have to be effectively protected against microbial and fungal attacks. PMID:18675913

  5. Direct bony invasion of malignant melanoma

    OpenAIRE

    Mula Viswanath; Mandal Adhip; Britton Edward; Shanker Vaidyanathan

    2009-01-01

    Malignant melanoma is known to spread by local extention, by the lymphatics by the blood stream. Direct invasion of the bone from a cutaneous melanoma is unknown. Hence, this case is presented in view of its rarity. A 75-year-old Caucasian lady presented with a small papillary lesion in the region of a recurrent chronic cellulitis on the lower third of the lateral aspect of the right leg. Histopathology diagnosed the lesion as locally advanced malignant melanoma. Radiological investigations b...

  6. Attenuation artifact from sclerotic bone can mimic active bone metastasis on PET-CT.

    Science.gov (United States)

    Ho, Linh; Seto, John

    2006-11-01

    We report the PET-CT appearance of sclerotic bone mimicking active bone metastasis in a 57-year-old woman with right breast cancer and bone and hepatic metastases. Hybrid PET-CT was performed 1 month after completion of surgery and chemoradiation treatment. PET-CT demonstrated hypermetabolic foci in the right pulmonary hilum and liver. Increased hypermetabolic activity in L1 and L3 vertebral bodies was also seen corresponding to sclerotic vertebral bodies on CT study. The activity in L1 and L3 vertebral bodies was not visualized on nonattenuation-corrected images, consistent with an attenuation correction artifact resulting from extensive sclerosis in these regions. PMID:17053397

  7. Globally sclerotic glomeruli in IgA nephropathy patients

    OpenAIRE

    Mohammadi Torbati Peyman

    2012-01-01

    Implication for health policy/practice/research/medical education:Oxford classification system was based on actual clinical data, international collaboration, and validation of the reproducibility of defining pathologic lesions. The strongest pathologic predictor of clinical outcome in IgA nephropathy is the extent of tubular atrophy and interstitial fibrosis.

  8. Radiographic Interpretation of Experimentally Produced Bony Defect According to kVp

    International Nuclear Information System (INIS)

    The purpose of this experiment was to evaluate radiographic interpretation of various sized 60 periapical and 60 cancellous lesions in 10 mandibular sections of 5 dogs according to kVp (65, 70, 75, 80 and 85 kVp). The results were as follows; The change of kilovoltage within 65 kVp-85 kVp range did not have influence on the radiographic interpretation of the same-sized bony defects at the constant radiographic density (p>0.05). When the bony defects were less than the size of No.2 round bur, radiographic interpretation of bony defects prepared with No.2 round bur was easier than those prepared with No.1 round bur at 80-85 kVp in periapical region (p0.05). From the results of densitometric analysis, there was a difference in densitometric measurements at the same radiographic interpretation scores, and aluminum equivalent differences of 0.15-1.66 mm thickness were needed for radiographic interpretation.

  9. Subperiostial and intracortical aneurysmal bony cyst - Cases report

    International Nuclear Information System (INIS)

    The aneurismal bony cyst is a benign bony tumor that is presented in the second decade of the life; it commits the bones around the knee, later elements of the column and flue proximal. It diagnoses it is clinical and radiological; it confirms by means of biopsy that should discard concomitant malignancy. This tumor can have an aggressive behavior for what is important to give him a meticulous treatment with resection, curettage and bony implant. The radiotherapy has very precise indications and it should not be used of routine by the malignancies risk. Their prognostic it is quite good

  10. Pupal cuticle proteins of Manduca sexta: characterization and profiles during sclerotization.

    Science.gov (United States)

    Hopkins, T L; Krchma, L J; Ahmad, S A; Kramer, K J

    2000-01-01

    Proteins in pupal abdominal cuticle of the tobacco hornworm, Manduca sexta, were characterized during the pre-ecdysial and post-ecdysial periods of sclerotization and endocuticle formation. Protein extractability decreased dramatically as the cuticle became sclerotized through 6 h post-ecdysis, but increased rapidly from 9 to 48 h as endocuticular layers were secreted. Nearly 100 proteins that were extracted from pre-ecdysial cuticle became largely insoluble during sclerotization. Three major proteins in this group destined to become exocuticle had apparent molecular masses (Mapp) of 20, 27 and 36 kDa, and were designated MS-PCP20, MS-PCP27, and MS-PCP36. Amino acid analysis revealed glycine to predominate in all three proteins, and alanine, aspartate, glutamate, proline and serine were also relatively abundant. Histidine residues, which provide sites for adduct and cross-link formation with quinone metabolites of N-beta-alanyldopamine during sclerotization of pupal cuticle, ranged from 2 to 3 mol %. N-Terminal amino acid analysis of MSPC-20 and MSPC-36 also revealed some sequence similarities indicating they may be related. An almost entirely new group of proteins appeared by 9 h as endocuticule secretion began, and these increased in abundance through 48 h post-ecdysis. Two of these were major proteins with Mapps of 33 and 34 kDa, and they also had close similarities in their N-terminal amino acid sequences. This study showed that the large number of proteins secreted into the presumptive exocuticle of the pupa before ecdysis are involved in sclerotization reactions and as a consequence become largely insoluble. The epidermis then switches to the secretion of an entirely new group of proteins that are involved in formation of the endocuticle. PMID:10646967

  11. Direct bony invasion of malignant melanoma

    Directory of Open Access Journals (Sweden)

    Mula Viswanath

    2009-01-01

    Full Text Available Malignant melanoma is known to spread by local extention, by the lymphatics by the blood stream. Direct invasion of the bone from a cutaneous melanoma is unknown. Hence, this case is presented in view of its rarity. A 75-year-old Caucasian lady presented with a small papillary lesion in the region of a recurrent chronic cellulitis on the lower third of the lateral aspect of the right leg. Histopathology diagnosed the lesion as locally advanced malignant melanoma. Radiological investigations by X-ray and magnetic resonance imaging revealed malignant infiltration of the tibia in its mid and lower third with two soft tissue metastatic masses adjacent. Histology following amputation confirmed malignant melanoma with cranial resection margin involvement. She underwent a further above-knee amputation followed by chemotherapy. The patient recovered from the amputation but subsequently died 6 months later due to bronchopneumonia from lung metastasis.

  12. Effects of Altered Catecholamine Metabolism on Pigmentation and Physical Properties of Sclerotized Regions in the Silkworm Melanism Mutant

    OpenAIRE

    Qiao, Liang; Li, Yuanhao; Xiong, Gao; Liu, Xiaofan; He, Songzhen; Tong, Xiaoling; Wu, Songyuan; Hu, Hai; Wang, Rixin; Hu, Hongwei; Chen, Lushi; Zhang, Li; Wu, Jie; Dai, Fangyin; Lu, Cheng

    2012-01-01

    Catecholamine metabolism plays an important role in the determination of insect body color and cuticle sclerotization. To date, limited research has focused on these processes in silkworm. In the current study, we analyzed the interactions between catecholamines and melanin genes and their effects on the pigmentation patterns and physical properties of sclerotized regions in silkworm, using the melanic mutant melanism (mln) silkworm strain as a model. Injection of ?-alanine into mln mutant s...

  13. Model sclerotization studies. 3. Cuticular enzyme catalyzed oxidation of peptidyl model tyrosine and dopa derivatives.

    Science.gov (United States)

    Sugumaran, M; Ricketts, D

    1995-01-01

    Incubation of N-acetyltyrosine methyl ester with cuticular enzymes, isolated from the wandering stages of Calliphora sp larvae, resulted in the generation of N-acetyldopa methyl ester when the reaction was carried out in the presence of ascorbate which prevented further oxidation of the o-diphenolic product. Enzymatic oxidation of N-acetyldopa methyl ester ultimately generated dehydro N-acetyldopa methyl ester. The identity of enzymatically produced N-acetyldopa methyl ester and dehydro N-acetyldopa methyl ester has been confirmed by comparison of the ultraviolet and infrared spectral and chromatographic properties with those of authentic samples as well as by nuclear magnetic resonance studies. Since N-acetyldopaquinone methyl ester was also converted to dehydro N-acetyldopa methyl ester and tyrosinase was responsible for the oxidation of N-acetyldopa methyl ester, a scheme for the cuticular phenoloxidase catalyzed conversion of N-acetyltyrosine methyl ester to dehydro N-acetyldopa methyl ester involving the intermediary formation of the quinone and the quinone methide is proposed to account for the observed results. The conversion of N-acetyldopa methyl ester to dehydro derivative remarkably resembles the conversion of the sclerotizing precursor, N-acetyldopamine, to dehydro-N-acetyldopamine observed in the insect cuticle. Based on these comparative studies, it is proposed that peptidyl dopa derivatives could also serve as the sclerotizing precursors for the sclerotization of the insect cuticle. PMID:7803812

  14. Identification of the gene encoding bursicon, an insect neuropeptide responsible for cuticle sclerotization and wing spreading.

    Science.gov (United States)

    Dewey, Elizabeth M; McNabb, Susan L; Ewer, John; Kuo, Gloria R; Takanishi, Christina L; Truman, James W; Honegger, Hans-Willi

    2004-07-13

    To accommodate growth, insects must periodically replace their exoskeletons. After shedding the old cuticle, the new soft cuticle must sclerotize. Sclerotization has long been known to be controlled by the neuropeptide hormone bursicon, but its large size of 30 kDa has frustrated attempts to determine its sequence and structure. Using partial sequences obtained from purified cockroach bursicon, we identified the Drosophila melanogaster gene CG13419 as a candidate bursicon gene. CG13419 encodes a peptide with a predicted final molecular weight of 15 kDa, which likely functions as a dimer. This predicted bursicon protein belongs to the cystine knot family, which includes vertebrate transforming growth factor-beta (TGF-beta) and glycoprotein hormones. Point mutations in the bursicon gene cause defects in cuticle sclerotization and wing expansion behavior. Bioassays show that these mutants have decreased bursicon bioactivity. In situ hybridization and immunocytochemistry revealed that bursicon is co-expressed with crustacean cardioactive peptide (CCAP). Transgenic flies that lack CCAP neurons also lacked bursicon bioactivity. Our results indicate that CG13419 encodes bursicon, the last of the classic set of insect developmental hormones. It is the first member of the cystine knot family to have a defined function in invertebrates. Mutants show that the spectrum of bursicon actions is broader than formerly demonstrated. PMID:15242619

  15. Aspects of cuticular sclerotization in the locust, Scistocerca gregaria, and the beetle, Tenebrio molitor.

    Science.gov (United States)

    Andersen, Svend Olav; Roepstorff, Peter

    2007-03-01

    The number of reactive amino groups in cuticular proteins decreases during the early period of insect cuticular sclerotization, presumably due to reaction with oxidation products of N-acetyldopamine (NADA) and N-beta-alanyldopamine (NBAD). We have quantitated the decrease in cuticular N-terminal amino groups and lysine epsilon-amino groups during the first 24h of sclerotization in adult locusts, Schistocerca gregaria, and in larval and adult beetles, Tenebrio molitor, as well as the increase in beta-alanine amino groups in Tenebrio cuticle. The results indicate that nearly all glycine N-terminal groups and a significant part of the epsilon-amino groups from lysine residues are involved in the sclerotization process in both locusts and Tenebrio. A pronounced increase in the amount of free beta-alanine amino groups was observed in cuticle from adult Tenebrio and to a lesser extent also in Tenebrio larval cuticle, but from locust cuticle no beta-alanine was obtained. Hydrolysis of sclerotized cuticles from locusts and Tenebrio by dilute hydrochloric acid released a large number of compounds containing amino acids linked to catecholic moieties. Products have been identified which contain histidine residues linked via their imidazole group to the beta-position of various catechols, such as dopamine, 3,4-dihydroxyphenyl-ethanol (DOPET), and 3,4-dihydroxyphenyl-acetaldehyde (DOPALD), and a ketocatecholic compound has also been identified composed of lysine linked via its epsilon-amino group to the alpha-carbon atom of 3,4-dihydroxyacetophenone. Some of the hydrolysis products have previously been obtained from sclerotized pupal cuticle of Manduca sexta [Xu, R., Huang, X., Hopkins, T.L., Kramer, K.J., 1997. Catecholamine and histidyl protein cross-linked structures in sclerotized insect cuticle. Insect Biochemistry and Molecular Biology 27, 101-108; Kerwin, J.L., Turecek, F., Xu, R., Kramer, K.J., Hopkins, T.L., Gatlin, C.L., Yates, J.R., 1999. Mass spectrometric analysis of catechol-histidine adducts from insect cuticle. Analytical Biochemistry 268, 229-237; Kramer, K.J., Kanost, M.R., Hopkins, T.L., Jiang, H., Zhu, Y.C., Xu, R., Kerwin, J.L., Turecek, F., 2001. Oxidative conjugation of catechols with proteins in insect skeletal systems. Tetrahedron 57, 385-392], but the lysine-dihydroxyacetophenone compound and the histidine-DOPALD adduct have not been reported before. It is suggested that the compounds are derived from NADA and NBAD residues which were incorporated into the cuticle during sclerotization, and that the lysine-dihydroxyacetophenone as well as the DOPET and DOPALD containing adducts are degradation products derived from cross-links between the cuticular proteins, whereas the dopamine-containing adducts are derived from a non-crosslinking reaction product. PMID:17296497

  16. Bony exostosis of the atlas with resultant cranial nerve palsy

    Energy Technology Data Exchange (ETDEWEB)

    Slavotinek, J.P.; Sage, M.R. (Flinders Medical Centre, Bedford Park (Australia). Dept. of Radiology); Brophy, B.P. (Flinders Medical Centre, Bedford Park (Australia). Dept. of Neurosurgery)

    1991-10-01

    A case of tenth and twelfth nerve compression secondary to a bony exostosis of the first cervical vertebra is described. This uncommon phenomenon serves to outline the importance of imaging the course of a cranial nerve when no intracranial abnormality is demonstrable on CT or MRI. The radiologic features of spinal osteochondromas are reviewed. (orig.).

  17. La displasia cemento ósea florida y su diagnóstico diferencial / The Florid cemento-bony dysplasia and the differential diagnosis

    Scientific Electronic Library Online (English)

    Allan Ulisses, Carvalho de Melo; Cyntia, Ferreira Ribeiro; Thiago, de Santana Santos; Luciana, Barreto Aguiar; Betsabé, Azevedo Rocha; Paulo, Almeida Júnior; Ricardo Luiz, Cavalcanti Albuquerque Júnior.

    2011-09-01

    Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Las lesiones benignas fibro-óseas de los maxilares constituyen un grupo diverso de enfermedades con una característica histológica común: la sustitución de hueso normal por tejido compuesto de colágeno y fibroblastos, con cantidades variables de una sustancia mineral que puede ser de hueso, cemento [...] o ambos. Estas lesiones incluyen la displasia fibrosa, la displasia cemento-ósea en sus variantes: periapical, focal o florida, el cementoma gigantiforme familiar y el fibroma osificante cemento-osificante. La osteomielitis es un proceso inflamatorio agudo o crónico de los espacios medulares o corticales del hueso, que se extiende más allá del sitio inicial de desenvolvimiento. La osteomielitis esclerosante difusa es más frecuente en adultos, principalmente en la mandíbula. Se presenta radiográficamente como una lesión radiopaca difusa adyacente a los dientes, que puede ser multifocal. El objetivo de este trabajo fue describir un caso inusual de lesión fibro-ósea, cuyo diagnóstico diferencial se hizo también con la osteomielitis de los maxilares. Se concluyó que las lesiones fibro-óseas benignas, presentaron muchas similitudes con respecto a sus aspectos clínicos, radiográficos e histológicos. Por lo tanto, es fundamental el análisis conjunto de estas informaciones para obtener un diagnóstico definitivo. Abstract in english The benign fibrous-bony lesions are a diverse group of diseases with common features: replacement of normal bone by tissue composed of collagen and fibroblasts, with variable amounts of a mineral substance that could be bone, cement or both. These lesions include the fibrous dysplasia, the periapica [...] l cement-bony dysplasia, focal or florid, familiar giant cementoma and ossifying fibroma (cement-ossifying). Osteomyelitis is an acute or chronic inflammatory process of medullar or cortical spaces of bone extending beyond the onset site of development. Diffuse sclerosing osteomyelitis involves to adults mainly the mandible and radiographically is a diffuse radiopaque lesion adjacent to teeth and could be multifocal. The aim of present paper is to describe an uncommon case of fibrous-bony lesion also diagnosed with maxillary osteomyelitis. We conclude that the above mentioned lesions are very similar regarding its clinical, radiographic and histological features. Thus, it is fundamental the combined analysis of these informations to obtain a definite diagnosis.

  18. Dasatinib as salvage therapy for steroid refractory and imatinib resistant or intolerant sclerotic chronic graft-versus-host disease.

    Science.gov (United States)

    Sánchez-Ortega, Isabel; Servitje, Octavio; Arnan, Montserrat; Ortí, Guillermo; Peralta, Teresa; Manresa, Federico; Duarte, Rafael F

    2012-02-01

    Sclerotic chronic graft-versus-host disease (scGVHD) is a severe form of this disease that resembles systemic sclerosis and has limited and disappointing treatment options. Tyrosine kinase inhibitors (TKI) targeting up-regulated profibrotic pathways, such as imatinib mesylate, have been proposed as a potential therapeutic approach for patients with scGVHD. Dasatinib, a second-generation TKI with a well-established safety and efficacy profile in chronic myeloid leukemia patients, who are refractory or intolerant to imatinib, has also shown potent antifibrotic effects. We present here the first direct clinical evidence, from 3 patients treated in a small single-center series, suggesting that dasatinib can be a therapeutic option for patients with severe scGVHD resistant or intolerant to imatinib. All patients achieved partial response, with improvement in scGHVD target organs severity, joint mobility, lung impairment, and deep fibrotic lesions. This clinical response has remained stable or continued to improve after a median of 22 months (20-25) on dasatinib treatment, with very good tolerance. In addition, corticosteroids could be discontinued or significantly reduced in all patients. This clinical evidence suggests that dasatinib could be a safe and effective alternative for scGVHD patients refractory to corticosteroids and resistant or intolerant to imatinib. Based on these preliminary findings, and in order to address appropriate patient selection, time of intervention, and choice of drug, future larger studies should more formally establish the efficacy and safety of second-generation TKI for the treatment of scGVHD. PMID:22068151

  19. A case report of odontogenic myxoma with characteristic multilocular lesion

    International Nuclear Information System (INIS)

    Although odontogenic myxoma (OM) has various radiographic appearances, the characteristic features of OM are the multilocular radiolucent lesion, straight bony septa along the margin forming either square or triangular spaces. We present a case of OM in a 25-year old-male patient. Multilocular radiolucent lesion on the left mandible body showed tennis racket appearance. Cone beam computed tomography (CBCT) showed straight bony septa along the margin and cortical perforation. This CBCT features would have significantly contributed to allowing a diagnosis of OM. We think that this case shows characteristic radiographic features of odontogenic myxoma.

  20. Studies on the enzymes involved in puparial cuticle sclerotization in Drosophila melanogaster.

    Science.gov (United States)

    Sugumaran, M; Giglio, L; Kundzicz, H; Saul, S; Semensi, V

    1992-01-01

    The properties of cuticular enzymes involved in sclerotization of Drosophila melanogaster puparium were examined. The cuticle-bound phenoloxidase from the white puparium exhibited a pH optimum of 6.5 in phosphate buffer and oxidized a variety of catecholic substrates such as 4-methylcatechol, N-beta-alanyldopamine, dopa, dopamine, N-acetyldopamine, catechol, norepinephrine, 3,4-dihydroxyphenylglycol, 3,4-dihydroxybenzoic acid, and 3,4-dihydroxyphenylacetic acid. Phenoloxidase inhibitors such as potassium cyanide and sodium fluoride inhibited the enzyme activity drastically, but phenylthiourea showed marginal inhibition only. This result, coupled with the fact that syringaldazine served as the substrate for the insoluble enzyme, confirmed that cuticular phenoloxidase is of the "laccase" type. In addition, we also examined the mode of synthesis of the sclerotizing precursor, 1,2-dehydro-N-acetyldopamine. Our results indicate that this catecholamine derivative is biosynthesized from N-acetyldopamine through the intermediate formation of N-acetyldopamine quinone and N-acetyldopamine quinone methide as established for Sarcophaga bullata [Saul, S. and Sugumaran, M., F.E.B.S. Letters 251, 69-73 (1989)]. Accordingly, successful solubilization and fractionation of cuticular enzymes involved in the introduction of a double bond in the side chain of N-acetyldopamine indicated that they included o-diphenoloxidase, 4-alkyl-o-quinone:p-quinone methide isomerase, and N-acetyldopamine quinone methide:dehydro N-acetyldopamine isomerase and not any side chain desaturase. PMID:1600191

  1. Laccase2 is required for sclerotization and pigmentation of Aedes albopictus eggshell.

    Science.gov (United States)

    Wu, Xiansheng; Zhan, Ximei; Gan, Ming; Zhang, Dongjing; Zhang, Meichun; Zheng, Xiaoying; Wu, Yu; Li, Zhuoya; He, Ai

    2013-05-01

    Laccase (EC 1.10.3.2) is a member of multicopper oxidases that have been found in higher plants, fungus, bacterium, and insects. Two types of laccase genes have been detected in many species of insects: laccase1 and laccase2. It has been identified that laccase2 enzyme may play a key role in sclerotization and pigmentation of insect cuticle. But few attentions were given to the biological role of laccase2 in the synthesizing of similar structures, such as oothecae, eggshell, or silk cocoons. We cloned laccase2 gene from Aedes albopictus, one main mosquito vector of dengue virus in China. An upregulation of laccase2 gene was observed after a blood meal in female adult mosquitoes, suggesting that laccase2 gene may have an involvement in the development of ovary. RNA interference experiment was performed by using adult female mosquitoes. Female mosquitoes were injected with 20 ng of double-strain RNA into the thorax. Pigmentation of mosquito eggshell was blocked that these eggs never became dark. And the incomplete sclerotization of eggshell weakened the stability and flexibility of the eggs. These eggs without enough protection were deformed and died in water. These results demonstrate that laccase2 plays a critical role in the development of eggs of A. albopictus. Laccase2 may provide a novel target for mosquito control and management. PMID:23455937

  2. Canine hip dysplasia: significance of early bony spurring

    International Nuclear Information System (INIS)

    It is the purpose of this study to call attention to new bone production that often occurs early in the sequence of pathological changes associated with canine hip dysplasia. New bone production extending to bony remodeling, as well as femoral head subluxation, both occur in the sequence of pathologic changes associated with canine hip dysplasia. Subluxation is considered primary, while osteoarthrosis is a secondary feature, and both are used in the diagnosis of canine hip dysplasia. This report concerns the significance of the presence of a solitary bony osteophyte, or spur, that is frequently evident on the caudal aspect of the femoral neck as viewed on the conventional ventrodorsal projection. This report utilizes findings from pelvic radiographs of 605 dogs (five breeds). There was a greater frequency (54%)of this bony change in cases diagnosed radiographically as dysplastic than in cases diagnosed as normal(15%).Thus, it is suggested that this minimal radiographic change can be used as an indicator of early canine hip dysplasia, especially in the absence of subluxation of the femoral head

  3. Wind rotor power station BONI-ShHV

    International Nuclear Information System (INIS)

    Wind rotor power station (WRPS) BONI-ShHV has following advantages : the increase of installation stability by rise of wind velocity and rotation speed of rotor due to gyroscopic effect; the absence noise and vibration; the safety for birds and animals; ability of compact installation and creation of series of wind power dams with higher capacity; the simplicity and fast assembling and putting into operation. The price of 1 k W of installing capacity is lower about 2.5-3 times compare to usual WRPS due to simple kinematic scheme. WRPS has high specific output of electrical energy due to use of low and long existing wind velocity and due to short storms, giving greater power. It has ability to be replayed when average annual wind velocity is above 5.5 m/s in comparison with propeller WRPS, which are never repaying. WRPS BONI-ShHV are made on the plants of Republic of Kazakhstan, and tested in wind velocity range up 45 m/s, have experience of 3 years of operation, showing their reliability and effectiveness. The repayment period of individual WRPS BONI-0.5/6 ShHV is from 10 month to 1 year depending on average annual velocity

  4. Imaging pattern of calvarial lesions in adults

    International Nuclear Information System (INIS)

    Calvarial lesions often present themselves as clinically silent findings on skull radiographs or as palpable masses that may cause localized pain or soreness. This review aims to explore the radiographic, computed tomography (CT), and magnetic resonance imaging (MRI) characteristics of calvarial neoplastic, inflammatory, and congenital lesions that are common in adults in order to facilitate a structured approach to their diagnosis and limit the differential diagnosis. In addition to reviewing the literature, we reviewed the records of 141 patients of the Montreal Neurological Institute and Hospital with radiologically documented calvarial lesions between 2001 and June 2009. CT is ideal for detecting bony lesions and is helpful in precisely localizing a lesion pre-surgically. MRI is best at identifying intradiploic lesions before they affect the cortical tables and is able to establish extraosseous involvement, especially when paramagnetic contrast is employed. (orig.)

  5. Imaging pattern of calvarial lesions in adults

    Energy Technology Data Exchange (ETDEWEB)

    Garfinkle, Jarred; Melancon, Denis; Cortes, Maria; Tampieri, Donatella [Montreal Neurological Institute and Hospital-McGill University Health Center, Department of Diagnostic and Interventional Neuroradiology, Montreal, Quebec (Canada)

    2011-10-15

    Calvarial lesions often present themselves as clinically silent findings on skull radiographs or as palpable masses that may cause localized pain or soreness. This review aims to explore the radiographic, computed tomography (CT), and magnetic resonance imaging (MRI) characteristics of calvarial neoplastic, inflammatory, and congenital lesions that are common in adults in order to facilitate a structured approach to their diagnosis and limit the differential diagnosis. In addition to reviewing the literature, we reviewed the records of 141 patients of the Montreal Neurological Institute and Hospital with radiologically documented calvarial lesions between 2001 and June 2009. CT is ideal for detecting bony lesions and is helpful in precisely localizing a lesion pre-surgically. MRI is best at identifying intradiploic lesions before they affect the cortical tables and is able to establish extraosseous involvement, especially when paramagnetic contrast is employed. (orig.)

  6. The application of bone scintigraphy in bony metastases of the common malignant solid tumors in children

    International Nuclear Information System (INIS)

    Objective: Skeleton was one of the most commonly seen metastatic sites in childhood malignant solid tumors. Bone scintigraphy might be of great value in revealing the bony metastases in children of malignancies. Methods: Whole-body bone scan was performed in 202 children with lymphomas (n=91) , neuroblastomas (NB, n=81), rhabdomyosarcomas (RS, n=20), and Wilms tumors (WT, n=10). The images were retrospectively analyzed as the incidence, sites, and image characteristics of the bone involvements. Results: Ninety-two of 202 patients (45.5%) showed positive findings in their bone scans. Solitary bone lesions were found in 20, whereas multiple infiltrations were founded in 72 children. Lower extremity and vertebras were common sites of skeletal metastases. Thirty-eight of 91 lymphomas (41.8%) had bone metastases, with incidental finding of kidney involvement in 15 (16.5%). Forty-six of 81 NB (56.8%) had bone involvement, with 30 primary lesions showed abnormal uptake. Eight of 20 RS manifested abnormal uptakes on their skeletons, whereas 10 WT had normal bone scans. Conclusions: Bone scintigraphy was of great value in the diagnosis of bone infiltrations of children's common malignant solid tumors. Bone scintigraphy also contributed to the detection of kidney involvement of lymphoma. (authors)

  7. Reexamination of the mechanisms of oxidative transformation of the insect cuticular sclerotizing precursor, 1,2-dehydro-N-acetyldopamine.

    Science.gov (United States)

    Abebe, Adal; Zheng, Dong; Evans, Jason; Sugumaran, Manickam

    2010-09-01

    1,2-dehydro-N-acetyldopamine (dehydro NADA) is an important catecholamine derivative formed during the sclerotization of insect cuticle. Earlier we have reported that tyrosinase-catalyzed oxidation of dehydro NADA produces a reactive quinone methide imine amide that forms adducts and cross-links through its side chain, thereby accounting for sclerotization reactions. Recently, laccase has also been identified as a key enzyme associated with sclerotization. Hence, we re-examined oxidation of dehydro NADA by tyrosinase and laccase using high performance liquid chromatography - tandem mass spectrometry. Tyrosinase-catalyzed oxidation of dehydro NADA not only generated dimers as reported earlier, but also generated significant amounts of oligomers. The course of laccase-catalyzed oxidation of dehydro NADA significantly differed from the tyrosinase reaction kinetically and mechanistically. Laccase failed to produce any detectable quinone or quinone methide as the primary two-electron oxidation product. Since laccases are known to generate primarily semiquinones as the initial products, lack of accumulation of two-electron oxidation products indicated that laccase reaction is primarily occurring via free radical coupling mechanism. Consistent with this proposal, laccase-catalyzed oxidation of dehydro NADA, resulted in the production of largely dimeric products and failed to produce any significant amount of oligomeric materials. These studies call for radical coupling as yet another major mechanism for sclerotization of insect cuticle. PMID:20600898

  8. CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts: preliminary results

    International Nuclear Information System (INIS)

    Objective: To evaluate CT-guided once-through bilateral percutaneous needle puncturing, aspiration and injection of sclerotic agents (ethanol) in treating bilateral multiple renal cysts. Methods: CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy was performed in 19 patients with bilateral multiple renal cysts. First, under CT guidance the puncture points and puncture routs were decided, then, puncturing, aspiration, rinsing and ethanol injection of the cysts were taken place by turn. The clinical results were analyzed. Results: bilateral percutaneous needle puncturing sclerotic therapy was successfully completed in all 19 cases. The whole procedure was well tolerated by all patients. The mean operative time was 23 minutes with a range of 20-35 minutes. No severe complications occurred. Conclusion: With proficient manipulation, CT-guided bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts can be smoothly carried out. The technique can reduced the number of sclerotherapy times, cut down the medical expenses and, therefore, get twofold results with half the effort. (authors)

  9. The evaluation of bony union after frontofacial distraction.

    Science.gov (United States)

    Eley, Karen A; Witherow, Helen; Hayward, Richard; Evans, Robert; Young, Karen; Clark, Allan; Dunaway, David

    2009-03-01

    Frontofacial advancement by distraction osteogenesis using the rigid external distraction device has become an accepted treatment for the deformity associated with craniofacial dysostoses (e.g., Crouzon, Apert, and Pfeiffer syndromes). The technical and physiological principles of osteogenesis distraction are well understood. This study documents the pattern of calcification at the osteotomy sites after distraction by analysis of serial three-dimensional computed tomography (CT) scans. The CT scans of 25 patients (11 with Crouzon, 6 with Apert, and 8 with Pfeiffer syndrome) were analyzed. Eleven individual areas along the osteotomy lines were assessed for evidence of bone formation. Scores were assigned within 4 categories ranging from no bone, calcification without bridge formation, a bony bridge, to complete bony infill (>95%). The scans were reviewed on 2 separate occasions by 2 independent assessors. There was high concordance both for intraobserver and interobserver scores. Rigid external distraction frame removal was undertaken after a 6-week consolidation period. All CT scan timings were calculated from this date. Of the 25 patients studied, 16 patients had CT scans available at 3 to 6 months, 12 at 9 to 12 months, and 7 at or more than 18 months. The scans were available in standard coronal slices with three-dimensional reconstructions. Bone formation is most consistently seen in the pterygoid region with calcification consistently occurring earlier and more completely in this area. Bone formation was often delayed in the orbital region and severely delayed or absent in the frontal region and zygomatic arches. There was no significant difference in the order or quality of bony union for the 3 underlying craniofacial dysostoses. This preliminary study confirms the clinical impression that bone formation after distraction is greatest in the pterygoid regions. The clinical implications of these findings are discussed. PMID:19258910

  10. Correlations between activity of tartrate-resistant acid phosphatase-5b and whole body bone scan in patients of breast cancer with bony metastases

    International Nuclear Information System (INIS)

    Objective: Tartrate-resistant acid phosphatase 5b (TRAP-5b) is a novel marker for evaluating osteoclastic activity and rate of bone resorption. The study observed the changes of circulating TRAP-5b activity and findings of bone scans in breast cancer patients with suspicious bony metastases. Methods: A total of 34 breast cancer patients with suspicious bony metastases were studied. Blood sampling and Tc-99m MDP (20mCi) whole body scans were performed at the same time. Specimens were stored at -70 and were simultaneously analyzed for activity of circulating TRAP-5b using a home-made EIA method (normal reference value: 3) groups. Results: Six patients revealed limited lesions (LL) and the other 28 revealed extended lesions (EL). Of the 34 patients, 20 received repeated bone scans which showed 7 in regression and 13 in progression of the bony lesions after anti-cancer treatment. The activity of TRAP-5b decreased significantly in regression group (mean±SD, 4.05±0.81 vs. 2.36±0.88 U/L; P<0.01) but not changed apparently in progression group (5.39±2.37 vs. 5.58±2.08 U/L). The TRAP-5b activity, however, significantly correlated with NL seen on bone scan (r= 0.52, P<0.01). Conclusion: TRAP-5b might be a suitable marker to evaluate status of bony metastases in patients with breast cancer anses in patients with breast cancer and might also provide a reference to therapeutic response in this patient group

  11. Computed tomography in bony stenosis of the cervical spinal canal

    International Nuclear Information System (INIS)

    This communication summarizes the author's attempts at evaluation of the cervical spinal canal in cases of localized or generalized spinal stenosis with computed tomography. As the scanner used neither had a tiltable gantry nor a scanogram facility he was forced to develop means to correctly position patients and localize scan levels. CT appears well suited for the evaluation of the dimensions of the cervical spinal canal, although meticulous positioning is of the utmost importance. It is often also the radiographic method which provides the most important diagnostic information in the various disease entities causing bony stenosis of the cervical spinal canal. (Auth.)

  12. Lifa Disease: Frictional Dermal Melanosis over Bony Prominences (Clinicopathological Study

    Directory of Open Access Journals (Sweden)

    Khalifa E. Sharquie

    2012-09-01

    Full Text Available Background: Lifa disease (Frictional dermal melanosis over bony prominences has been described in Iraq for the first time in 1993, as a new distinctive pigmentary skin condition that followed chronic friction with a body washing agent (lifa during bathing. Objective: To assess this increasingly common problem where still many doctors unaware about its presence especially in other Middle East countries. Patients and Methods: A case series descriptive study done in Departments of Dermatology-Najaf and Baghdad Teaching Hospitals, between March 2007- Oct.2008. Full history and clinical examination were done for all patients including Wood's light examination. Biopsies were taken from 21 patients and sent for hematoxylin-eosin and Congo red stains. Results: Fifty two (49 female and 3 male patients with typical clinical features of lifa disease were studied. The mean age of presentation was 27.92 ± 7.58 years. All patients were slim with prominent bones and low body mass index, used lifa vigorously during bathing.Pigmentation was distributed bilaterally and symmetrically over bony prominences. The most common affected sites were: clavicular areas (67.3% and upper back (42%. Wood's light and histopathological examinations revealed dermal melanosis. No amyloid deposit was detected by using Congo red stain in any patient. Conclusions: Lifa disease is a common distinctive pigmentary disfiguring problem especially among females. The histopathology showed dermal melanosis, and might be confused with other pigmentary problems like macular amyloidosis.

  13. Congenital bony syngnathia with unilateral palatal shelf and soft palate agenesis.

    Science.gov (United States)

    Kona?, Ersoy; Tunçbilek, Gökhan; Kayikçio?lu, Aycan; Ozgür, Figen

    2010-09-01

    Congenital fusion of upper and lower jaw is rare. Only 35 bony syngnathia have been reported up to date, and 9 of them revealed posterior topography. A 10-day-old female infant with facial asymmetry, limited mouth opening, and cardiac murmurs is presented. The radiological findings revealed congenital bony fusion of right coronoid process of the mandible to posterior maxillary region and right palatal shelf agenesis of palatal bone, which seems to be the first case in the literature. Classification systems of bony syngnathia and applied treatment procedures for palatal closure and release of the bony fusion are discussed. PMID:20856069

  14. Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice

    Scientific Electronic Library Online (English)

    Yinghua, Song; Lubing, Zhu; Ming, Li.

    1350-13-01

    Full Text Available SciELO Brazil | Language: English Abstract in english OBJECTIVE: To investigate the antifibrotic effects of crocetin in scleroderma fibroblasts and in sclerotic mice. METHODS: Skin fibroblasts that were isolated from three systemic scleroderma (SSc) patients and three healthy subjects were treated with crocetin (0.1, 1 or 10 ?M). Cell proliferation [...] was measured with an MTT assay. Alpha-smooth muscle actin was detected via an immunohistochemical method. Alpha 1 (I) procollagen (COL1A1), alpha 1 (III) procollagen (COL3A1), matrix metalloproteinase (MMP)-1 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 mRNA levels were measured using real-time PCR. SSc mice were established by the subcutaneous injection of bleomycin. Crocetin (50 mg/kg/d) was injected intraperitoneally for 14 days. Dermal thickness and lung fibrosis were assessed with Masson's trichrome staining. Plasma ET-1 was detected with an enzyme-linked immunosorbent assay (ELISA). Skin and lung ET-1 and COL1A1 mRNA levels were measured via real-time PCR. RESULTS: Crocetin inhibited the proliferation of SSc and normal fibroblasts, an effect that increased with crocetin concentration and incubation time. Crocetin decreased the expression of ?-SMA and the levels of mRNA for COL1A1, COL3A1 and matrix metalloproteinase-1, while crocetin increased TIMP-1 mRNA levels in both SSc and normal fibroblasts. Skin and lung fibrosis was induced, and the levels of ET-1 in the plasma, skin and lungs were elevated in bleomycin-injected mice. Crocetin alleviated the thickening of the dermis and lung fibrosis; decreased COL1A1 mRNA levels in the skin and lung; and simultaneously decreased ET-1 concentrations in the plasma and ET-1 mRNA levels in the skin and lungs of the bleomycin-induced sclerotic mice, especially during the early phase (weeks 1-3). CONCLUSION: Crocetin inhibits cell proliferation, differentiation and collagen production in SSc fibroblasts. Crocetin alleviates skin and lung fibrosis in a bleomycin-induced SSc mouse model, in part due to a reduction in ET-1.

  15. Detrimental influences of intraluminally-administered sclerotic agents on surrounding tissues and peripheral nerves: An experimental study

    OpenAIRE

    Fujiki, Masahide; Kurita, Masakazu; Ozaki, Mine; Kawakami, Hayato; Kaji, Nobuyuki; Takushima, Akihiko; Harii, Kiyonori

    2012-01-01

    The minimally-invasive nature of sclerotherapy makes it one of the first treatment options for venous malformations, although treatment-related complications, such as peripheral nerve paralysis, have been reported in some clinical cases. However, no studies of the aetiology of the detrimental effects of intraluminally-administered sclerotic agents on the surrounding tissues, including the peripheral nerves, have yet been published. This study therefore investigated the influences of intralumi...

  16. Stable free radicals in insect cuticles: electron spin resonance spectroscopy reveals differences between melanization and sclerotization.

    Science.gov (United States)

    Kayser, Hartmut; Palivan, Cornelia G

    2006-09-15

    Insect cuticles (exuviae; cast skins) were examined for the first time by ESR spectroscopy for the presence of stable free radicals, as found in melanins. All cuticles, except those from a locust albino strain, irrespective of the presence of melanin, provided single-line signals of varied g-values and linewidths. The ESR signals of melanins, isolated or in cuticles, were characterized by g-values sclerotized cuticles, lacking melanin, showed g-values >2.004 and broad linewidths of 5-11 G. The melanin spectra were comparable to those reported for eumelanins with indol-based monomers. Minor signals ascribed to pheomelanins were found in several probes. The 'sclerotin' spectra were broader and displayed unresolved hyperfine structure in some cases. As for melanins, the location and environment of the radicals in cuticles giving rise to the two types of ESR spectra could not be assigned. Changes in the radical environment due to insecticide or solvent treatment can be detected by ESR spectroscopy. PMID:16901457

  17. Involvement of tyrosine residues, N-terminal amino acids, and beta-alanine in insect cuticular sclerotization.

    Science.gov (United States)

    Andersen, Svend Olav

    2007-09-01

    During sclerotization of insect cuticle the acyldopamines, N-acetyldopamine (NADA) and N-beta-alanyldopamine (NBAD), are oxidatively incorporated into the cuticular matrix, thereby hardening and stabilizing the material by forming crosslinks between the proteins in the cuticular matrix and by forming polymers filling the intermolecular spaces in the cuticle. Sclerotized cuticle from the locust, Schistocerca gregaria, and the beetle, Tenebrio molitor, was hydrolyzed in dilute hydrochloric acid, and from the hydrolysates some components presumably degradation products of cuticular crosslinks were isolated. In two of the components, the sidechain of 3,4-dihydroxyacetophenone was linked to the amino groups of glycine and beta-alanine, respectively, and in the third component to the phenolic group of tyrosine. These three compounds, glycino-dihydroxyacetophenone, beta-alanino-dihydroxyacetophenone, and O-tyrosino-dihydroxyacetophenone, as well as the previously reported compound, lysino-dihydroxyacetophenone [Andersen, S.O., Roepstorff, P., 2007. Aspects of cuticular sclerotization in the locust, Schistocerca gregaria, and the beetle, Tenebrio molitor. Insect Biochem. Mol. Biol. 37, 223-234], are suggested to be degradation products of cuticular crosslinks, in which amino acid residues formed linkages to both the alpha- and beta-positions of the sidechain of acyldopamines. PMID:17681236

  18. Quantitative computed tomography as a test of endurance for evaluation of bony plates

    International Nuclear Information System (INIS)

    Quantitative computed tomography was used to determine the radiodensity of bony plates. The CT scans provided information regarding radiodensity of bony plates and allowed to verify the uniformity of bone mineral density in their scope. The proposed methodology should be considered as another tool for determining the resistance of these biomaterials. (author)

  19. Radiographic Study on the Bony Changes of Mandibular Condyle Head in Temporomandibular Disorder Patients

    International Nuclear Information System (INIS)

    The author has studied radiographic bony changes of mandibular condyle head in temporomandibular disorder patients using Oblique lateral transcranial projection, Orthopantomography, and Tomography. The bony change types and the frequencies of occurrence and the incidences of bony changes in three different radiographic techniques were examined. The coincidences of body change types between the Oblique lateral transcranial projection and the lateral part of Tomogram, the Orthopantomogram and the medial part of Tomogram were also examined. The results were as follows: 1. The mean age of patients was 31.7 years and under 40 years were 24 patients, women were 27 patients, men were 4 patients. 2. The observable cases of bony changes in all three radiographic techniques were 19 cases (50%) of 38 cases and the observable cases of bony changes in only Tomography were 5 cases (13.2%). 3. The most frequent radiographic bony change type was osteophyte and next orders were flattening, erosion, concavity. 4. The positional incidences of bony changes in Tomogram were 31 cases in lateral part and 27 cases in central part. 5. The coincidence of bony change types between the oblique lateral transcranial projection and the lateral part of Tomogram was 80%, and the coincidence between the Orthopantomogram and the medial part of Tomogram was 76.9%.

  20. Unusual cause of generalized osteolytic vertebral lesions: a case report

    Directory of Open Access Journals (Sweden)

    Nanda Sudip

    2007-06-01

    Full Text Available Abstract Background Vertebral sarcoidosis is an extremely rare form of osseous sarcoidosis. Although osseous sarcoidosis is almost always an incidental finding of sarcoidosis elsewhere in the body, vertebrae may be the primary disease site. Involvement of vertebrae is usually localized and sclerotic or lytic. Case presentation We describe a case of extensive asymptomatic vertebral involvement by sarcoid with osteolytic lesions. Making the diagnosis requires biopsy and ruling out other commoner causes of osteolytic vertebral lesions. Conclusion We report this case in the hope of expanding the knowledge of osseous sarcoidosis. Our patient was unique in that all involvement was axial with sparing of the peripheral skeleton, near absence of any other organ involvement, diffuse involvement of the whole spine and osteolytic bone lesions.

  1. Modulation of renin angiotensin system predominantly alters sclerotic phenotype of glomeruli in HIVAN.

    Science.gov (United States)

    Plagov, Andrei; Lan, Xiqian; Rai, Partab; Kumar, Dileep; Lederman, Rivka; Rehman, Shabina; Malhotra, Ashwani; Ding, Guohua; Chander, Praveen N; Singhal, Pravin C

    2014-12-01

    HIV-associated nephropathy (HIVAN) is a common complication of HIV-1 infection in patients with African ancestry in general and with APOL1 gene risk variants in particular. Although collapsing glomerulopathy is considered a hallmark of HIVAN, significant numbers of glomeruli in patients with HIVAN also display other variants of focal segmental glomerulosclerosis (FSGS). We propose that collapsed glomeruli as well as glomeruli with other variants of FSGS are manifestations of HIVAN and their prevalence depends on associated host factors. We explored the role of the renin-angiotensin system (RAS) in the manifestation of any specific glomerular phenotype in HIVAN. To evaluate the role of the RAS we have used a genetically engineered mouse model of HIVAN (Tg26) with two and four copies of angiotensinogen (Agt) gene (Tg26/Agt2 and Tg26/Agt4). In Tg26/Agt2, 1 out of 6 glomeruli exhibited sclerosed phenotype, whereas 1 out of 25 glomeruli displayed collapsed phenotype; on the other hand, in Tg26/Agt4, 1 out of 3 glomeruli exhibited sclerotic phenotype and only 1 out of 7 glomeruli showed collapsed phenotype. To inhibit the effect of RAS, Tg26/Agt2 were administered captopril, aliskiren, aliskiren plus captopril or aliskiren plus telmisartan by miniosmotic pumps for 4 weeks. In all experimental groups there was a significant reduction in percentage of sclerosed glomeruli and only minimal reduction in collapsed glomeruli compared to normal saline receiving Tg26/Agt2. These findings suggest that the manifestation of the sclerosed phenotype in HIVAN is predominantly dependent on activation of the RAS. PMID:24892944

  2. Algodystrophy in children and young adults with isotopic bony hypofixation. A propos of 5 observations

    International Nuclear Information System (INIS)

    The authors report 5 observations of young adults 3 teen-agers and 2 children suffering from algodystrophy, and in whom isotopic exploration of the skeleton disclosed a clear bony hypofixation during the entire evolution. These observations confirm their 1981 work concerning a young adult suffering from algodystrophy with isotopic bony hypofixation. Recent Canadian and American studies emphasize also the frequency of isotopic hypofixation in children algodystrophy. It seems, therefore, that isotopic bony hypofixation (linked perhaps to a decreased blood flow), is rather specific of algodystrophy in young subjects

  3. The Hill-Sachs lesion: diagnosis, classification, and management.

    Science.gov (United States)

    Provencher, Matthew T; Frank, Rachel M; Leclere, Lance E; Metzger, Paul D; Ryu, J J; Bernhardson, Andrew; Romeo, Anthony A

    2012-04-01

    The Hill-Sachs lesion is an osseous defect of the humeral head that is typically associated with anterior shoulder instability. The incidence of these lesions in the setting of glenohumeral instability is relatively high and approaches 100% in persons with recurrent anterior shoulder instability. Reverse Hill-Sachs lesion has been described in patients with posterior shoulder instability. Glenoid bone loss is typically associated with the Hill-Sachs lesion in patients with recurrent anterior shoulder instability. The lesion is a bipolar injury, and identification of concomitant glenoid bone loss is essential to optimize clinical outcome. Other pathology (eg, Bankart tear, labral or capsular injuries) must be identified, as well. Treatment is dictated by subjective and objective findings of shoulder instability and radiographic findings. Nonsurgical management, including focused rehabilitation, is acceptable in cases of small bony defects and nonengaging lesions in which the glenohumeral joint remains stable during desired activities. Surgical options include arthroscopic and open techniques. PMID:22474094

  4. MRI findings of cyclops lesions of the knee

    Scientific Electronic Library Online (English)

    C, Minné; MD, Velleman; FE, Suleman.

    2012-04-01

    Full Text Available SciELO South Africa | Language: English Abstract in english Cyclops lesions develop in the anterior aspect of the intercondylar notch typically after anterior cruciate ligament (ACL) reconstruction or injury. It is a lesion consisting of fibrous tissue with or without cartilage and bony components. A cyclops lesion is one of the causes for reduced extension [...] and, in the cases reported here, also knee pain or discomfort after ACL reconstruction. We present the MRI features, particularly the features on proton density weighted turbo spin echo (PDW TSE) and proton density weighted turbo spin echo fat saturation (PDW TSE FS) sequences of four cases of cyclops lesions, and distinguish between the MRI findings of large and small lesions. We also describe a cyclops lesion after a posterior cruciate ligament reconstruction, not described in literature before.

  5. Imaging of extradural spinal lesions

    International Nuclear Information System (INIS)

    There is a wide variety of spinal extradural tumors. In addition to real neoplasms, degenerative diseases, congenital abnormalities and inflammatory disorders can be causes of extradural masses. Due to the bony boundary of the spinal canal, both benign as well as malignant masses can cause progressive neurological deficits including paraplegia. Most of the spinal tumors are benign (hemangioma of the vertebral body, degenerative diseases). In younger patients congenital abnormalities and primary tumors of the spine have to be considered, whereas in adults the list of differential diagnoses should include secondary malignancies such as metastases and lymphomas as well as metabolic disorders such as osteoporotic vertebral compression fracture and Paget's disease. Cross-sectional imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) of the spine often help to make a specific diagnosis of extradural spinal lesions and represent important tools for tumor staging and preoperative evaluation. (orig.)

  6. Correction of bony genu recurvatum combined with ligamentous instability of the knee: three case reports.

    Science.gov (United States)

    Jung, Young Bok; Lee, Yong Seuk; Jung, Ho Joong; Nam, Chang Hyun; Yang, Jae Joon

    2008-02-01

    We report our experiences for treating the bony genu recurvatum combined with ligamentous instability that needed both osteotomy and ligament reconstruction in three cases. The bony component was corrected according to normal tibial slope, patellar height and limb length. After the osteotomy, we reevaluated the instability of the knee and performed ligament reconstruction if the patients had ligamentous instability even though the osteotomy was done. PMID:17899000

  7. Computed tomography in the diagnosis of lumbar disk herniation with eroded bony cortex

    International Nuclear Information System (INIS)

    Erosive bony change of the spine had not been well documented in relation to the lumber disk herniation. We have recently experienced four cases with such bony change as erosion of the spinal bodies and lamina in association with extrusion and migration of the nucleus pulposus. Soft tissue masses associated with disk herniation always had hyperdensity as compared with dural sac and were continuous with lumber disk even if the masses had migrated. (author)

  8. The paediatric wrist revisited - findings of bony depressions in healthy children on radiographs compared to MRI

    International Nuclear Information System (INIS)

    The presence of erosions is used for diagnosis and monitoring of disease activity in juvenile idiopathic arthritis (JIA). Assessment of carpal bone erosions in children is challenging due to lack of normal references. To define normal appearances of bony depressions in the wrist on radiographs and MRI. MRI and radiography of the wrist were performed in 88 healthy children, 5-15 years of age. We assessed the number of bony depressions within the carpals/proximal metacarpals on both modalities, separately and combined. A total of 75 carpal depressions were identified on radiography compared to 715 on MRI. The number of bony depressions identified radiographically showed no statistically significant difference across age-groups. Within the metacarpals, there was no significant difference between bony depressions identified by MRI or radiography, except at the bases of the second metacarpal. Bony depressions that resemble erosions are normal findings in the wrist in children. MRI identifies more depressions than radiographs in the carpus. Some bony depressions occur at typical locations and should be accounted for when assessing the wrist in JIA to avoid overstaging. (orig.)

  9. The paediatric wrist revisited - findings of bony depressions in healthy children on radiographs compared to MRI

    Energy Technology Data Exchange (ETDEWEB)

    Avenarius, Derk M.F.; Eldevik, Petter [University Hospital North Norway, Department of Radiology, Tromsoe (Norway); Ording Mueller, Lil-Sofie [University Hospital North Norway, Department of Radiology, Tromsoe (Norway); Great Ormond Street Hospital for Children, Department of Radiology, London (United Kingdom); Owens, Catherine M. [Great Ormond Street Hospital for Children, Department of Radiology, London (United Kingdom); University College London, Institute of Child Health, London (United Kingdom); Rosendahl, Karen [Haukeland University Hospital, Department of Radiology, Bergen (Norway); University of Bergen, Department of Surgical Sciences, Bergen (Norway); Great Ormond Street Hospital for Children, Department of Radiology, London (United Kingdom)

    2012-07-15

    The presence of erosions is used for diagnosis and monitoring of disease activity in juvenile idiopathic arthritis (JIA). Assessment of carpal bone erosions in children is challenging due to lack of normal references. To define normal appearances of bony depressions in the wrist on radiographs and MRI. MRI and radiography of the wrist were performed in 88 healthy children, 5-15 years of age. We assessed the number of bony depressions within the carpals/proximal metacarpals on both modalities, separately and combined. A total of 75 carpal depressions were identified on radiography compared to 715 on MRI. The number of bony depressions identified radiographically showed no statistically significant difference across age-groups. Within the metacarpals, there was no significant difference between bony depressions identified by MRI or radiography, except at the bases of the second metacarpal. Bony depressions that resemble erosions are normal findings in the wrist in children. MRI identifies more depressions than radiographs in the carpus. Some bony depressions occur at typical locations and should be accounted for when assessing the wrist in JIA to avoid overstaging. (orig.)

  10. Ipsilateral retinofugal projections in a percomorph bony fish: their experimental induction, specificity and maintenance.

    Science.gov (United States)

    Wilm, C; Fritzsch, B

    1990-01-01

    Adult bony fish possess only a small ipsilateral retinofugal projection, if any. Experimental manipulation, such as unilateral enucleation, can lead to an enhancement of this projection. We examined the patterns of, as well as the conditions for the development and maintenance of an enhanced ipsilateral retinofugal projection (EIRP) after nerve crush, after enucleation, and after various combinations of both types of surgery in juvenile and adult Haplochromis burtoni (Cichlidae). Retinal projections were labeled either unilaterally with horseradish perixodase, or with the lipophilic fluorescent dye DiI in aldehyde-fixed animals, or bilaterally with differently colored fluorescent dextran amines. Unilateral nerve crush always leads to the regeneration of retinofugal fibers to the contralateral tectum but spares some contralateral diencephalic nuclei. In addition, unilateral or bilateral nerve crush in many cases, and unilateral enucleation in some cases, leads to the development of an EIRP to the ipsilateral diencephalon and tectum. This EIRP persists (4 months and longer postoperatively) in only 10% of the unilaterally enucleated animals, in none of the animals subjected to unilateral nerve crush and in 79% of the animals subjected to bilateral nerve crush. All unilaterally enucleated animals in which the remaining, contralateral optic nerve was crushed develop and maintain an EIRP. These data suggest that nerve crush alone is sufficient to cause regenerating fibers to project, at least transiently, to the ipsilateral side of the brain. When the normal contralateral projection is either absent or in the process of regeneration, an EIRP can be maintained. In the latter case, alternate bands or patches of ipsi- and contralateral fibers in the tectum may result. Ipsilateral fibers follow unusual pathways by recrossing at the rostral diencephalon. Likewise, regenerating contralateral retinal fibers grow differently in this area; here, where the optic-nerve projection is reorganized into the optic tract, many regenerating fibers are deflected to the ipsilateral side of the brain. Despite atypical routes taken by some fibers, the EIRP nevertheless ends only in specific retinorecipient areas. An EIRP develops independently of the age of the animal, independently of the time lapse between enucleation and nerve lesion, and independently of persisting debris. However, in animals receiving an optic nerve lesion a long time after unilateral enucleation, the size of the EIRP and its tectal extent are reduced compared to that in animals enucleated around the same time as receiving the crush of the contralateral optic nerve. PMID:2285855

  11. Reconstruction of multiple myeloma lesions around the pelvis and acetabulum.

    Science.gov (United States)

    Sakellariou, Vasileios I; Mavrogenis, Andreas F; Savvidou, Olga; Sim, Franklin H; Papagelopoulos, Panayiotis J

    2014-10-19

    Multiple myeloma is a malignancy of monoclonal plasma cells (plasma cells are of B-lymphocyte lineage of the hematopoietic system). It is the second most prevalent blood malignancy after non-Hodgkin's lymphoma. It accounts for approximately 1 % of all malignancies and 2 % of all cancer deaths. Bony involvement is very common; the incidence of pelvic and periacetabular involvement in MM is reported to be around 6 %. Lytic lesions comprise a hallmark of multiple myeloma, which may be complicated with pathologic fractures in a substantial percentage of patients. Pelvic and periacetabular bony involvement of multiple myeloma is associated with some unique characteristics regarding the biomechanics of this specific anatomical region, the morbidity, the overall survival, and prognosis, which all reflect to impairment of quality of life. In this paper, we review the special features of multiple myeloma lesions around the pelvis and acetabulum and present an algorithm of management with the use of current surgical techniques. PMID:25326868

  12. CT-guided percutaneous biopsy of sacral lesions

    International Nuclear Information System (INIS)

    Objective: To improve both the technique and the clinical application of CT-guided percutaneous aspiration biopsy for sacral lesions. Methods: CT-guided percutaneous aspiration biopsy was performed in 21 patients with sacral lesions. By using Ackerman drilling needle, trigger type biopsy needle or Chiba needle, both bony and non-bony specimens were collected. Results: The procedure was successfully done in all patients and the pathologic diagnosis was obtained in 95.2%. Failure occurred in one case as only necrotic tissue and blood clot were collected in biopsy. Conclusion: As a simple, safe and reliable technique, CT-guided percutaneous aspiration biopsy is very helpful in making correct preoperative diagnosis, providing important preoperative reference for the surgeons. (authors)

  13. An osseous lesion in a 10-year-old boy with Hodgkin's lymphoma: a case report

    OpenAIRE

    Moser Asher; Zudekov Vadiem; van den Akker Machiel; Kapelushnik Joseph

    2011-01-01

    Abstract Introduction Osseous involvement of Hodgkin's lymphoma is uncommon. When osteolytic lesions are seen on imaging it is important to evaluate potential other causes. Case presentation We report the case of a 10-year-old Caucasian boy who presented to our facility with a bony lesion of the right clavicle and enlarged cervical lymph nodes. A simultaneous biopsy of the lymph node and of the osteolytic process of his right proximal clavicle was performed and revealed two different kinds of...

  14. Incidence of dehiscence of the bony roof of the superior semicircular canal by CT imaging

    International Nuclear Information System (INIS)

    Dehiscence of the bony roof of the superior semicircular canal (SSCC) is rare, but it has been recognized by otologists since Minor et al first described superior canal dehiscence syndrome (SCDS). In this study, dehiscence of the bony roof of SSCC was incidentally detected in three patients with benign paroxysmal positional vertigo out of 49 serial patients with vertigo and dizziness by multi-slice computed tomography. Although detection of dehiscence of the SSCC by ultra-high-resolution CT imaging of the temporal bones has been required for a diagnosis of SCDS, this study showed that dehiscence of the bony roof of the SSCC can be an incidental finding and therefore is not specific for SCDS. (author)

  15. Application of radionuclide SPECT imaging in assessment of bony defect repair

    International Nuclear Information System (INIS)

    PURPOSE: To assess bony defect repair with SPECT imaging. METHODS: 40 New Zealand rabbits with 1.5 cm bony defect on bilateral radius were divided into 4 groups with different implantation: A, composites of bone morphogenetic protein (BMP) and fibrin, B, BMP, C, fibrin, D, no implantation as control. The defects were examined by multiphase imaging in different weeks after operation. RESULTS: The regenerative bone salt deposition was found one week after operation, the highest level of deposition was in group A, and the second in group B. The bone regeneration revealed by SPECT imaging was in concordance with the results of histological and radiological examination. CONCLUSION: The combination use of SPECT and routine examination can assess bony defect repair more accurately and earlier

  16. Effects of altered catecholamine metabolism on pigmentation and physical properties of sclerotized regions in the silkworm melanism mutant.

    Science.gov (United States)

    Qiao, Liang; Li, Yuanhao; Xiong, Gao; Liu, Xiaofan; He, Songzhen; Tong, Xiaoling; Wu, Songyuan; Hu, Hai; Wang, Rixin; Hu, Hongwei; Chen, Lushi; Zhang, Li; Wu, Jie; Dai, Fangyin; Lu, Cheng; Xiang, Zhonghuai

    2012-01-01

    Catecholamine metabolism plays an important role in the determination of insect body color and cuticle sclerotization. To date, limited research has focused on these processes in silkworm. In the current study, we analyzed the interactions between catecholamines and melanin genes and their effects on the pigmentation patterns and physical properties of sclerotized regions in silkworm, using the melanic mutant melanism (mln) silkworm strain as a model. Injection of ?-alanine into mln mutant silkworm induced a change in catecholamine metabolism and turned its body color yellow. Further investigation of the catecholamine content and expression levels of the corresponding melanin genes from different developmental stages of Dazao-mln (mutant) and Dazao (wild-type) silkworm revealed that at the larval and adult stages, the expression patterns of melanin genes precipitated dopamine accumulation corresponding to functional loss of Bm-iAANAT, a repressive effect of excess NBAD on ebony, and upregulation of tan in the Dazao-mln strain. During the early pupal stage, dopamine did not accumulate in Dazao-mln, since upregulation of ebony and black genes led to conversion of high amounts of dopamine into NBAD, resulting in deep yellow cuticles. Scanning electron microscope analysis of a cross-section of adult dorsal plates from both wild-type and mutant silkworm disclosed the formation of different layers in Dazao-mln owing to lack of NADA, compared to even and dense layers in Dazao. Analysis of the mechanical properties of the anterior wings revealed higher storage modulus and lower loss tangent in Dazao-mln, which was closely associated with the altered catecholamine metabolism in the mutant strain. Based on these findings, we conclude that catecholamine metabolism is crucial for the color pattern and physical properties of cuticles in silkworm. Our results should provide a significant contribution to Lepidoptera cuticle tanning research. PMID:22937004

  17. MRI of bone marrow oedema associated with focal bone lesions

    International Nuclear Information System (INIS)

    Aim: To quantify the volume of bone marrow oedema surrounding focal bone lesions and to identify its relevance relative to diagnosis. Methods: Three hundred and eighty-eight of 1456 patients included in the orthopaedic oncology database who underwent magnetic resonance imaging (MRI) demonstrated bone marrow oedema and were included in the study. There were 225 males and 163 females, age range 1-87 years (mean 29 years). MRI images were retrospectively reviewed and assessed for the extent of bone marrow oedema. The amount of oedema was graded: grade 1: oedema present but smaller than the lesion size; grade 2: oedema equivalent to the lesion size; grade 3: oedema greater than the lesion size. Results: There were 190 grade 1 lesions: 56% malignant, 33% benign, 11% non-neoplastic; 74 grade 2 lesions: 19% malignant, 50% benign, 31% non-neoplastic; and 124 grade 3 lesions: 10% malignant, 46% benign, 44% non-neoplastic. There was a significant relationship between oedema grade (i.e., volume of oedema) and final diagnosis (p < 0.0005). Conclusion: Bone marrow oedema may be associated with a wide range of focal bony lesions, including malignant, benign and non-neoplastic causes. As the volume of bone marrow oedema increases relative to the size of the underlying lesion, the probability that the underlying lesion is benign is increased

  18. Congenital complex corneal choristoma associated with unilateral bony calvarial defects, subcutaneous nodules, and alopecia.

    Science.gov (United States)

    Owen, Leah A; Ford, Joshua; Mamalis, Nick; Hoffman, Robert; Mifflin, Mark

    2015-04-01

    Complex corneal choristoma is a rare finding and its relationship with systemic disease is poorly understood. We present a 3-day-old boy with the constellation of left-sided congenital complex corneal choristoma, limbal dermoid, ipsilateral bony skull defects, and bilateral subcutaneous vascularized nodules with overlying alopecia and scalp nevi. To our knowledge this is the first case of complex choristoma involving the presence of associated bony calvarial defects. This presentation may contribute to a greater understanding of the systemic findings associated with the condition. Furthermore, it may shed light on the possible syndromic spectrum associated with complex choristoma and its underlying pathophysiology. PMID:25892046

  19. Parasellar lesions

    Energy Technology Data Exchange (ETDEWEB)

    Ruscalleda, J. [Hospital Sant Pau, Radiology Department, Neuroradiology, Barcelona (Spain)

    2005-03-01

    The sellar and parasellar region is an anatomically complex area that represents a crucial crossroad of important adjacent structures, e.g. orbits, cavernous sinus and its content, polygon of Willis, hypothalamus through the pituitary stalk and dural reflections forming the diaphragm sellae and the walls of the cavernous sinuses. Although the cavernous sinus represents the most relevant parasellar structure, from the practical and clinical point of view all the structures that surround the sella turcica can be included in the parasellar region. CT and, mainly, MRI are the imaging modalities to study and characterise the normal anatomy and the majority of processes in this region. We present a practical short review of the most relevant CT and MRI characteristics, such as location, nature of contrast enhancement and presence of cystic components, together with clinical findings, which permit differentiation of the most frequent and less common lesions found in the parasellar region. Learning objectives: A short review of the anatomy and clinical symptoms related to the parasellar region. Radiological characterisation, mainly by MRI, of the many lesions that alter the structure and function of sellar and parasellar anatomy. Description of the MRI features that permit differentiation among less common lesions. (orig.)

  20. Parasellar lesions

    International Nuclear Information System (INIS)

    The sellar and parasellar region is an anatomically complex area that represents a crucial crossroad of important adjacent structures, e.g. orbits, cavernous sinus and its content, polygon of Willis, hypothalamus through the pituitary stalk and dural reflections forming the diaphragm sellae and the walls of the cavernous sinuses. Although the cavernous sinus represents the most relevant parasellar structure, from the practical and clinical point of view all the structures that surround the sella turcica can be included in the parasellar region. CT and, mainly, MRI are the imaging modalities to study and characterise the normal anatomy and the majority of processes in this region. We present a practical short review of the most relevant CT and MRI characteristics, such as location, nature of contrast enhancement and presence of cystic components, together with clinical findings, which permit differentiation of the most frequent and less common lesions found in the parasellar region. Learning objectives: A short review of the anatomy and clinical symptoms related to the parasellar region. Radiological characterisation, mainly by MRI, of the many lesions that alter the structure and function of sellar and parasellar anatomy. Description of the MRI features that permit differentiation among less common lesions. (orig.)

  1. Clival Lesion incidentally discovered on cone-beam computed tomography: A case report and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Jadhav, Aniket B.; Tadinada, Aditya; Rengasamy, Kandasamy; Lurie, Alan G. [Dept. of Oral and Maxillofacial Radiology, University of Connecticut School of Dental Medicine, Farmington (United States); Douglas, Fellows [Division of Diagnostic Sciences and Therapeutics, University of Connecticut School of Medicine, Farmington (United States)

    2014-06-15

    An osteolytic lesion with a small central area of mineralization and sclerotic borders was discovered incidentally in the clivus on the cone-beam computed tomography (CBCT) of a 27-year-old male patient. This benign appearance indicated a primary differential diagnosis of non-aggressive lesions such as fibro-osseous lesions and arrested pneumatization. Further, on magnetic resonance imaging (MRI), the lesion showed a homogenously low T1 signal intensity with mild internal enhancement after post-gadolinium and a heterogeneous T2 signal intensity. These signal characteristics might be attributed to the fibrous tissues, chondroid matrix, calcific material, or cystic component of the lesion; thus, chondroblastoma and chondromyxoid fibroma were added to the differential diagnosis. Although this report was limited by the lack of final diagnosis and the patient lost to follow-up, the incidental skull base finding would be important for interpreting the entire volume of CBCT by a qualified oral and maxillofacial radiologist.

  2. Clival Lesion incidentally discovered on cone-beam computed tomography: A case report and review of the literature

    International Nuclear Information System (INIS)

    An osteolytic lesion with a small central area of mineralization and sclerotic borders was discovered incidentally in the clivus on the cone-beam computed tomography (CBCT) of a 27-year-old male patient. This benign appearance indicated a primary differential diagnosis of non-aggressive lesions such as fibro-osseous lesions and arrested pneumatization. Further, on magnetic resonance imaging (MRI), the lesion showed a homogenously low T1 signal intensity with mild internal enhancement after post-gadolinium and a heterogeneous T2 signal intensity. These signal characteristics might be attributed to the fibrous tissues, chondroid matrix, calcific material, or cystic component of the lesion; thus, chondroblastoma and chondromyxoid fibroma were added to the differential diagnosis. Although this report was limited by the lack of final diagnosis and the patient lost to follow-up, the incidental skull base finding would be important for interpreting the entire volume of CBCT by a qualified oral and maxillofacial radiologist.

  3. Suppression of bony growth of the orbit after radiotherapy for retinoblastoma

    International Nuclear Information System (INIS)

    Suppression of the growth of orbit and skull in 13 retinoblastoma patients treated by radiotherapy was investigated. The age of patients at the time of treatment ranged from 1 month to 6 years and 11 months. They were examined after three to 18 years. Suppression of the growth in involved areas and other parts of the skull within the beam of radiation were estimated by inspection, X-ray findings, and X-CT examinations. The involved orbit received more than 32 Gy, and the suppression of bone growth was prominent. At the opposite temporal bone, suppression of growth was prominent in eight cases out of 11, in these cases, the radiation dose was at least 14 Gy. Two cases, in whom the radiation dose was less than 12.6 Gy, have not shown any suppression of bony growth. Results were also obtained for a nominal single dose (ret). In all cases of more than 1,000 ret, suppression was prominent, but at less than 1,000 ret, four out of nine cases, and at less than 600 ret, two out of four cases showed suppression of bony growth. If the safety dose to avoid the suppression of bony growth is 400 ret, this is equivalent to three times the radiation dose of 200 cGy. In conclusion, the suppression of bony growth of the orbit and temporal area of the skull of young patients is caused by very small doses of radiation. (author)

  4. A technique for the quantification of the 3D connectivity of thin articulations in bony sutures.

    Science.gov (United States)

    Maloul, Asmaa; Fialkov, Jeffrey; Hojjat, Seyed-Parsa; Whyne, Cari M

    2010-04-19

    The anatomy and development of cranial and facial sutures have been studied in detail using histological sections, 2D radiographs and more recently CT imaging. However, little attention has been paid to evaluating and quantifying the connectivity of these thin cortical bone articulations. More recent technological advances such as micro-CT imaging has the potential to be used to provide quantitative measurements of 3D connectivity in bony articulations. This study presents a new technique for quantifying the connectivity of bony projections inside cranial and facial sutures using a combination of skeletonization, thinning algorithms and 3D intensity mapping. The technique is demonstrated in five sutures through semi-automated analysis and image processing of microCT scans. In the sagittal, coronal and frontozygomatic sutures an average bone connectivity of 6.6-11.6% was found with multiple bony projections providing an interlocking structure between adjacent bones. Much higher bone connectivity was present in the zygomaticotemporal and zygomaticomaxillary sutures (22.7-37.4%) with few bony projections. This method combining microCT scanning and image processing techniques was successfully used to quantify the connectivity of thin bone articulations and allowed detailed assessment of sutural fusion in 3D. The wider application of this technique may allow quantification of connectivity in other structures, in particular fracture healing of long bones. PMID:20036366

  5. Condylar bony changes in patients with temporomandibular disorders: a CBCT study

    Energy Technology Data Exchange (ETDEWEB)

    Nah, Kyung Soo [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Pusan National University, Yangsan (Korea, Republic of)

    2012-09-15

    Diagnosis of osteoarthritis most commonly depends on clinical and radiographic findings. The present study attempted to observe the bony changes in temporomandibular joint (TMJ) patients from all age groups. The first-visit clinical records and cone beam computed tomography (CBCT) data of 440 TMJs from 220 consecutive TMJ patients were reviewed retrospectively. The most frequent condylar bony change observed was sclerosis (133 joints, 30.2%) followed by surface erosion (129 joints, 29.3%), flattening of the articular surface (112 joints, 25.5%), and deviation in form (58 joints, 13.2%), which included 33 TMJs in a cane-shape, 16 with a lateral or medial pole depression, 6 with posterior condylar surface flattening, and 3 with a bifid-shaped condyle. Fifty-three joints (12.0%) showed hypoplastic condyles but only 1 joint showed hyperplasia. Osteophyte was found in 35 joints (8.0%) and subcortical cyst in 24 joints (5.5%), 5 of which had surface erosion as well. One hundred nineteen joints (27.0%) had only one kind of condylar bony change, 66 joints (15.0%) had two, 52 joints (11.8%) had three, 12 joints (5.0%) had four, and 6 joints (1.4%) had five kinds of condylar bony changes at the same time. Eighty-five (65.9%) of 129 joints with surface erosion had pain recorded at the chief complaint. With more widespread use of CBCT, more specific or detailed guidelines for osteoarthritis are needed.

  6. Bony spinal canal changes that differentiate conjoined nerve roots from herniated nucleus pulposus

    International Nuclear Information System (INIS)

    CT examinations of the lumbar spine in 12 consecutive patients with conjoined nerve roots were reviewed. Asymmetry of the bony spinal canal, seen as slight dilatation of the ipsilateral lateral recess, was present in all cases. This finding, which is not typically associated with extruded free intervertebral disk fragments, should serve to distinguish these two entities

  7. "Sub Specie Boni": The Comfort Zone of Self-Belief--A Dimension in Counseling Offenders.

    Science.gov (United States)

    Church, James Lee

    1996-01-01

    Claims that self-defeating behavior is a rational attempt to satisfy early, introjected messages about the type of person one is, arising from a desire for things perceived as good--sub specie boni. Examines the notion of the comfort zone, toxic shame, and therapists' responsibility to nourish acceptable joy. (RJM)

  8. "tres douee, bonne musicienne": die französische Komponistin Mel Bonis (1858 - 1937)

    OpenAIRE

    Hoffmann, Freia; Schenck, Dorothea

    2007-01-01

    Mit dieser Veröffentlichung publiziert der Verlag die erste entscheidende Monographie über Mel Bonis auf dem deutschen Buchmarkt. Deren Leben und dessen musikalischer Hintergrund im Paris der Gründerzeit werden ausführlich behandelt. Vor den Schilderungen der einzelnen Werkgruppen findet sich ein grundlegender Abschnitt über die Ästhetik und Musiksprache der Komponistin. Ebenso beeindruckend: die ausgedehnte Werkliste und ein Literaturverzeichnis, ebenso exemplarische Analysen ausgewäh...

  9. Detection of the Epstein-Barr Virus and DNA-Topoisomerase II-? in Recurrent and Nonrecurrent Giant Cell Lesion of the Jawbones

    OpenAIRE

    Zyada, Manal M.; Salama, Nagla M.

    2013-01-01

    The aims of this study were to determine whether the expression of Topo II-? correlates with presence of EBV in giant cell lesion of the jawbones and whether it is predictive of clinical biologic behavior of these lesions. Paraffin-embedded tissues from 8 recurrent and 7 nonrecurrent cases of bony GCLs and 9 peripheral giant cell lesions (PGCLs) as a control group were assessed for the expression of EBV and Topo II-? using immunohistochemistry. The results showed positive staining for Topo ...

  10. PET/MR imaging of bone lesions - implications for PET quantification from imperfect attenuation correction

    International Nuclear Information System (INIS)

    Accurate attenuation correction (AC) is essential for quantitative analysis of PET tracer distribution. In MR, the lack of cortical bone signal makes bone segmentation difficult and may require implementation of special sequences. The purpose of this study was to evaluate the need for accurate bone segmentation in MR-based AC for whole-body PET/MR imaging. In 22 patients undergoing sequential PET/CT and 3-T MR imaging, modified CT AC maps were produced by replacing pixels with values of >100 HU, representing mostly bone structures, by pixels with a constant value of 36 HU corresponding to soft tissue, thereby simulating current MR-derived AC maps. A total of 141 FDG-positive osseous lesions and 50 soft-tissue lesions adjacent to bones were evaluated. The mean standardized uptake value (SUVmean) was measured in each lesion in PET images reconstructed once using the standard AC maps and once using the modified AC maps. Subsequently, the errors in lesion tracer uptake for the modified PET images were calculated using the standard PET image as a reference. Substitution of bone by soft tissue values in AC maps resulted in an underestimation of tracer uptake in osseous and soft tissue lesions adjacent to bones of 11.2 ± 5.4 % (range 1.5-30.8 %) and 3.2 ± 1.7 % (range 0.2-4 %), respectively. Analysis of the spine and pelvic osseous lesions revealed a substantial dependence of the error on lesion composition. For predominantly sclerotic spine lesions, the mean underestimatiic spine lesions, the mean underestimation was 15.9 ± 3.4 % (range 9.9-23.5 %) and for osteolytic spine lesions, 7.2 ± 1.7 % (range 4.9-9.3 %), respectively. CT data simulating treating bone as soft tissue as is currently done in MR maps for PET AC leads to a substantial underestimation of tracer uptake in bone lesions and depends on lesion composition, the largest error being seen in sclerotic lesions. Therefore, depiction of cortical bone and other calcified areas in MR AC maps is necessary for accurate quantification of tracer uptake values in PET/MR imaging. (orig.)

  11. Esclerosis inflamatoria orbitaria y síndrome de fibrosis multifocal / Sclerotic inflammation of the orbit and multifocal fibrosclerosis syndrome

    Scientific Electronic Library Online (English)

    B., Mataix; E., López-Navarrete; M., López-Domínguez; R., Ángeles.

    2008-04-01

    Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Caso clínico: Mujer de 52 años que consulta en nuestro Servicio por proptosis bilateral. La aparición de sintomatología aguda digestiva durante el ingreso para el estudio de la proptosis, condujo al diagnóstico de un cuadro de fibroesclerosis multifocal, con afectación simultánea de los tejidos orbi [...] tarios, grasa mesentérica y tronco de encéfalo. Discusión: El pseudotumor esclerosante orbitario es una rara entidad clinicopatológica, cuyas características en la clínica y en las pruebas de imagen pueden ser similares a las del pseudotumor inflamatorio idiopático. El diagnóstico diferencial es importante porque ambos difieren tanto en su tratamiento como en su pronóstico. Abstract in english Clinical case: A fifty-two-year-old woman consulted our department because of a bilateral proptosis. The appearance of acute symptoms suggestive of a digestive disorder during her admission to hospital for the study of the proptosis, led to a diagnosis of multifocal fibrosclerosis with simultaneous [...] affliction of orbital tissue, mesenteric fat and the brain stem. Discussion: Idiopathic Sclerotic Inflammation of the orbit is a rare pathological entity, with similar clinical and radiological characteristics to orbital pseudo-tumour. The differential diagnosis is important because both these conditions differ in treatment and prognosis.

  12. Cellular localization of bursicon using antisera against partial peptide sequences of this insect cuticle-sclerotizing neurohormone.

    Science.gov (United States)

    Honegger, Hans-Willi; Market, Daniel; Pierce, Larry A; Dewey, Elizabeth M; Kostron, Barbara; Wilson, Melanie; Choi, Dennis; Klukas, Kathleen A; Mesce, Karen A

    2002-10-14

    Bursicon is the final neurohormone released at the end of the molting cycle. It triggers the sclerotization (tanning) of the insect cuticle. Until now, its existence has been verified only by bioassays. In an attempt to identify this important neurohormone, bursicon was purified from homogenates of 2,850 nerve cords of the cockroach Periplaneta americana by using high performance liquid chromatography technology and two-dimensional gel electrophoresis. Bursicon bioactivity was found in four distinct protein spots at approximately 30 kDa between pH 5.3 and 5.9. The protein of one of these spots at pH 5.7 was subsequently microsequenced, and five partial amino acid sequences were retrieved. Evidence is presented that two of these sequences are derived from bursicon. Antibodies raised against the two sequences labeled bursicon-containing neurons in the central nervous systems of P. americana. One of these antisera labeled bursicon-containing neurons in the crickets Teleogryllus commodus and Gryllus bimaculatus, and the moth Manduca sexta. A cluster of four bilaterally paired neurons in the brain of Drososphila melanogaster was also labeled. In addition, this antiserum detected three spots corresponding to bursicon in Western blots of two-dimensional gels. The 12-amino acid sequence detected by this antiserum, thus, seems to be conserved even among species that are distantly related. PMID:12271490

  13. Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin

    Scientific Electronic Library Online (English)

    Alexandra Patricia, Mena-Serrano; Eugenio Jose, Garcia; Miguel Munoz, Perez; Gislaine Cristine, Martins; Rosa Helena Miranda, Grande; Alessandro Dourado, Loguercio; Alessandra, Reis.

    2013-04-01

    Full Text Available SciELO Brazil | Language: English Abstract in english Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS) and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI), the 2-step self- [...] etch Adper SE Bond (3MESPE) and the 35% phosphoric acid (3MESPE) from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE) were applied on the bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm 2 ) and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material) was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment), according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05). Results: The duplication of the conditioning time favored only the GO adhesive (p

  14. Esclerosis inflamatoria orbitaria y síndrome de fibrosis multifocal Sclerotic inflammation of the orbit and multifocal fibrosclerosis syndrome

    Directory of Open Access Journals (Sweden)

    B. Mataix

    2008-04-01

    Full Text Available Caso clínico: Mujer de 52 años que consulta en nuestro Servicio por proptosis bilateral. La aparición de sintomatología aguda digestiva durante el ingreso para el estudio de la proptosis, condujo al diagnóstico de un cuadro de fibroesclerosis multifocal, con afectación simultánea de los tejidos orbitarios, grasa mesentérica y tronco de encéfalo. Discusión: El pseudotumor esclerosante orbitario es una rara entidad clinicopatológica, cuyas características en la clínica y en las pruebas de imagen pueden ser similares a las del pseudotumor inflamatorio idiopático. El diagnóstico diferencial es importante porque ambos difieren tanto en su tratamiento como en su pronóstico.Clinical case: A fifty-two-year-old woman consulted our department because of a bilateral proptosis. The appearance of acute symptoms suggestive of a digestive disorder during her admission to hospital for the study of the proptosis, led to a diagnosis of multifocal fibrosclerosis with simultaneous affliction of orbital tissue, mesenteric fat and the brain stem. Discussion: Idiopathic Sclerotic Inflammation of the orbit is a rare pathological entity, with similar clinical and radiological characteristics to orbital pseudo-tumour. The differential diagnosis is important because both these conditions differ in treatment and prognosis.

  15. Medial depression with bony dehiscence of lamina papyracea as an anatomic variation: CT evaluation

    International Nuclear Information System (INIS)

    To evaluate the incidence and CT findings of the medial depression and bony dehiscence of lamina papyracea as an anatomic variation. 1472 PNS CTs of the patients with symptoms of chronic sinusitis were retrospectively evaluated. The total incidence of depressed lamina papyracea as an anatomic variation was 3.5%(52/1472) on PNS CT. There was a statistically significant correlation between the increasing age and the incidence of depressed lamina papyracea. Depression of lamina papyracea anterior to the basal lamella were more common than those of the posterior depression. Associated findings were herniation of adjacent fatty tissue in all cases and the medial bowing and hypertrophied configuration of the medial rectus muscle without significant herniation in 19 cases(34%). Nontraumatic, asymptomatic depression with bony dehiscence of lamina papyracea as an anatomic variation is not uncommon with the incidence of 3.5%. Recognition of its existence and degree may be helpful in avoiding various ocular complication during ethmoid surgery

  16. Medial depression with bony dehiscence of lamina papyracea as an anatomic variation: CT evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Na, Sun Young; Lee, Young Uk; Youn, Eun Kyung; Suh, Sang Gyung; Kim, Dong Hyun [Koryo General Hospital, Seoul (Korea, Republic of)

    1994-09-15

    To evaluate the incidence and CT findings of the medial depression and bony dehiscence of lamina papyracea as an anatomic variation. 1472 PNS CTs of the patients with symptoms of chronic sinusitis were retrospectively evaluated. The total incidence of depressed lamina papyracea as an anatomic variation was 3.5%(52/1472) on PNS CT. There was a statistically significant correlation between the increasing age and the incidence of depressed lamina papyracea. Depression of lamina papyracea anterior to the basal lamella were more common than those of the posterior depression. Associated findings were herniation of adjacent fatty tissue in all cases and the medial bowing and hypertrophied configuration of the medial rectus muscle without significant herniation in 19 cases(34%). Nontraumatic, asymptomatic depression with bony dehiscence of lamina papyracea as an anatomic variation is not uncommon with the incidence of 3.5%. Recognition of its existence and degree may be helpful in avoiding various ocular complication during ethmoid surgery.

  17. Knee joint secondary motion accuracy improved by quaternion-based optimizer with bony landmark constraints.

    Science.gov (United States)

    Wang, Hongsheng; Zheng, Naiqaun Nigel

    2010-12-01

    Skin marker-based motion analysis has been widely used in biomechanical studies and clinical applications. Unfortunately, the accuracy of knee joint secondary motions is largely limited by the nonrigidity nature of human body segments. Numerous studies have investigated the characteristics of soft tissue movement. Utilizing these characteristics, we may improve the accuracy of knee joint motion measurement. An optimizer was developed by incorporating the soft tissue movement patterns at special bony landmarks into constraint functions. Bony landmark constraints were assigned to the skin markers at femur epicondyles, tibial plateau edges, and tibial tuberosity in a motion analysis algorithm by limiting their allowed position space relative to the underlying bone. The rotation matrix was represented by quaternion, and the constrained optimization problem was solved by Fletcher's version of the Levenberg-Marquardt optimization technique. The algorithm was validated by using motion data from both skin-based markers and bone-mounted markers attached to fresh cadavers. By comparing the results with the ground truth bone motion generated from the bone-mounted markers, the new algorithm had a significantly higher accuracy (root-mean-square (RMS) error: 0.7 ± 0.1 deg in axial rotation and 0.4 ± 0.1 deg in varus-valgus) in estimating the knee joint secondary rotations than algorithms without bony landmark constraints (RMS error: 1.7 ± 0.4 deg in axial rotation and 0.7 ± 0.1 deg in varus-valgus). Also, it predicts a more accurate medial-lateral translation (RMS error: 0.4 ± 0.1 mm) than the conventional techniques (RMS error: 1.2 ± 0.2 mm). The new algorithm, using bony landmark constrains, estimates more accurate secondary rotations and medial-lateral translation of the underlying bone. PMID:21142329

  18. 100-million-year dynasty of giant planktivorous bony fishes in the Mesozoic seas.

    OpenAIRE

    Friedman, M.; Shimada, K.; Martin, Ld; Everhart, Mj; Liston, J.; Maltese, A.; Triebold, M.

    2010-01-01

    Large-bodied suspension feeders (planktivores), which include the most massive animals to have ever lived, are conspicuously absent from Mesozoic marine environments. The only clear representatives of this trophic guild in the Mesozoic have been an enigmatic and apparently short-lived Jurassic group of extinct pachycormid fishes. Here, we report several new examples of these giant bony fishes from Asia, Europe, and North America. These fossils provide the first detailed anatomical information...

  19. Study of bony trabecular characteristics using bone morphometry and micro-CT

    International Nuclear Information System (INIS)

    The research was done to investigate the effectiveness of 2D bony morphometry and microstructure of micro-computed tomography (micro-CT) on the osteoporotic bony change. We performed the bone morphometric analysis of proximal femur in ovariectomized rabbits with BMD and micro-CT examination. Twenty-one female (Newzeland, about 16 weeks old, 2.9-3.4 kg) rabbits were used. Three rabbits were sacrificed on the day when experiment began (Basline). The remaining 18 rabbits were divided into two groups. One group was ovariectomized bilaterally (OVX) and the other animals were subjected to sham operation (Sham). Bone specimens were obtained from the right and left femur of sacrificed rabbits. At intervals of 1,2,3,5,6 months respectively, BMD tests were performed on the proximal on the proximal femur by using PIXImus 2 (GE Lunar Co. USA), 2-dimensional bone morphometric analysis by custom computer program and 2D / 3D bone structure analysis by micro-CT (Skyscan1072, Antwerpen, Belgium). Statistical analysis was carried out for the correlation between bone morphometry, micro-CT and BMD. BV/TV, Tb.Th, Tb.N of micro-CT parameters showed higher values in sham group than OVX group. N.Nd/Ar.RI, N.NdNd, N.NdTm, N. TmTm, PmB/Ar.RI, 3-D BoxSlope of 2D morphometric parameters showed higher values in Sham group than OVX group. The micro-CT parameters of Tb.Sp. Tb.N were statistically significant correlated with BMD respectively. Several 2D morphometric parameters were statistically sighometric parameters were statistically significant correlated with BMD respectively. Several parameters of 2D bony morphometry and micro-CT showed effective aspects on the osteoporotic bony change

  20. Treatment of painful bony metastasis of prostatic cancer by Samarium 153 (Quadramet)

    International Nuclear Information System (INIS)

    Full text: SUMMARY. Introduction: Despite of the progress realized in the treatment of prostatic cancer, the appearance of bony metastasis had limited considerably the life expectancy. In that case, pain is the most important symptom to consider because of its most frequency and the most difficult to manage. Its management needs a multidisciplinary approach with the objective of improving patients' life quality. Aim: The objective of the study was to evaluate the interest of metabolic radiotherapy to 153Samarium-EDTMP, for the pain treatment of bony metastasis of prostatic cancer. Material and method: This was a multicentric study where data were collected retrospectively lasting 40 months. The study was conducted in three departments of nuclear medicine: Institute Salah Azaiez, the center 'CERU', and military hospital of Tunis. Forty five patients with painful bony metastasis of prostatic cancer had been enrolled in the study. Efficacy and factors influencing treatment response had been assessed as well as toxicity and the cause of failures. Results: Positive response was obtained in 92.1% of cases and response was completed in 36.5% of cases. Results obtained after multiple administrations of treatment, showed that the cures could be repeated and could have results comparable to the first cure. The efficacy of our treatment is at least equivalent to the one obtained by the other methods of treatment, with very rare adverse events. The only toxicity was a e adverse events. The only toxicity was a hematological disorder that is usually moderated and reversible as well with complete recovery in around 8 weeks. Conclusion: Our results supported the efficacy of 'Samarium 153-EDTMP' in the management of painful bony metastasis of prostatic cancer. (author)

  1. Correction of bony deformities around knee by hemicallotasis using an innovative apparatus

    OpenAIRE

    Kundu Z; Sangwan S; Siwach R; Guliani Gulshan

    2005-01-01

    Background: Valgus and varus deformities around the knee are common. Various osteotomies and apparatuses have been described to correct these deformities. Methods: Bony deformities around knee joint in thirty patients (36 joints) were corrected by osteotomy in upper tibia or lower femur which was stabilized and distracted with innovatively designed and locally fabricated T-shaped external fixator-cum-distractor. The age of the patients ranged from 5 to 48 years. The causes of deformities w...

  2. Ultrasonographic findings of soft tissue lesions in extremities

    International Nuclear Information System (INIS)

    52 patients who had soft tissue lesions in extremity, buttock and shoulder,were studied by ultrasonography to evaluated the finding and significance of ultrasound study. The results were follows; 1. There were variable entities of diseases including 16 cases of Baker's cysts, 8 cases of abscesses, 8 cases of neoplasms, 4 case of hematomas and each case of joint effusion and bursitis, ganglion, thickening of soft tissue, muscle rupture and foreign body, respectively. 2. Baker's cyst was possibly diagnosis by characteristic site and finding with clinical history. 3. Abscess and hematoma showed hypoechoic or anechoic mass. Hematoma was easily diagnosed by associated findings with trauma, such as muscular swelling and rupture or bony fracture, but it was difficult to distinguish abscess from neoplasm due to similar finding. 4. Ultrasonography was a modality not only accurate for determining the presence, size and localization of lesion, but also easy for defining cyst or solid nature and relationship between lesion and adjacent structure

  3. Review of nomenclature revision of fibro-ossous lesions in the maxillofacial region

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Do [Wonkwang Univ. School of Dentistry, Iksan (Korea, Republic of)

    2007-03-15

    Fibro-osseous lesions are composed of connective tissue and varying amount of mineralized substances, which may be bony or cementum-like structures. It is necessary for oral radiologist to differentiate due to the tendency of these fibro-osseous lesions to show similar histopathologic appearances, while the management of each lesion is different. However we often encounter a little difficulty in judgement because there are some overlaps between concept of each lesions. So recently I suggest, we face a need to review basic concept and classification of several fibro-osseous jaw lesions. In this article, several fibro-osseous lesions, such as fibrous dysplasia, cemento-ossifying fibroma and cemento-osseous dysplasia, will be discussed basing on the review of literature. Particular emphasis will be made on the nomenclature revision of WHO's classification in 1992.

  4. Are diabetic foot lesions precipitated by accidental trauma?

    Science.gov (United States)

    Doshi, H K; Moissinac, K; Harwant, S

    2001-12-01

    Diabetic foot lesions may arise from frictional trauma due to tight or inappropriate footwear, repetitive stresses on parts of the foot, overlying bony prominence generated by walking and accidental trauma to the neuropathic foot. Many diabetics have been found to be unaware of their foot lesion, or know what the precipitating cause was. Based on the assumption that accidental trauma would affect the foot in a random fashion and result in lesions distributed evenly throughout the foot, a study was performed to determine whether foot lesions were distributed evenly or concentrated to certain areas of predilection. It was found that foot lesions were not evenly distributed but concentrated to certain areas of predilection. Even though relatively high proportion of the study population walked about in open slippers and barefeet, the study showed that accidental trauma was not a predominant precipitant of diabetic foot lesions. Diabetic foot lesions tend to occur as a result of cumulative, repetitive trauma to areas of prediliection rather than accidental trauma. PMID:14569763

  5. Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin

    Directory of Open Access Journals (Sweden)

    Alexandra Patricia Mena-Serrano

    2013-04-01

    Full Text Available Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI, the 2-step self-etch Adper SE Bond (3MESPE and the 35% phosphoric acid (3MESPE from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE were applied on the bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm 2 and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment, according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05. Results: The duplication of the conditioning time favored only the GO adhesive (p<0.05. Both application methods significantly increased the tubule area opening (p<0.05 compared to the controls. Conclusions: The efficacy of duplicating the conditioning time was only effective for the 1-step self-etch adhesive system tested.

  6. Computed tomographic features of the bony canal of the cochlear nerve in pediatric patients with unilateral sensorineural hearing loss

    International Nuclear Information System (INIS)

    The aim of this study was to evaluate the diameters of the various bony canals of the inner ear in patients with sensorineural hearing loss (SNHL) and establish criteria for detecting hypoplasia of the bony canal of the cochlear nerve. Measurements obtained in 118 patients without inner ear malformations among 160 patients with unilateral SNHL were analyzed. The diameters of the internal auditory canal and the bony canals of the cochlear, vestibular, and facial nerves were measured on transverse or coronal computed tomographic images. Mean values (±standard deviation (SD)) were compared between the affected and unaffected ears, and statistical analysis was done. The diameter of the bony canal of the cochlear nerve was significantly smaller in affected ears than in unaffected ears (P<0.01). The affected ears could be divided into groups with (72 ears) and without (46 ears) bony canal stenosis. Most (60%) of the patients with unilateral SNHL showed a significant difference in the diameters of the bony canals of the cochlear nerve between the affected and unaffected sides; moreover, the mean value was significantly smaller in affected ears. The diameter of <1.7 mm on transverse images or <1.8 mm on coronal images suggests hypoplasia. (author)

  7. Skeletal lesions in human tuberculosis may sometimes heal: an aid to palaeopathological diagnoses

    OpenAIRE

    Holloway, Kara L.; Link, Karl; Ru?hli, Frank J.; Henneberg, Maciej

    2013-01-01

    In three to five percent of active cases of tuberculosis, skeletal lesions develop. Typically, these occur on the vertebrae and are destructive in nature. In this paper, we examined cases of skeletal tuberculosis from a skeletal collection (Galler Collection) with focus on the manifestation of bony changes due to tuberculosis in various body regions in association with antibiotic introduction. This skeletal collection was created in 1925-1977 by a pathologist at the University Hospital in Zü...

  8. Arrested pneumatization of the sphenoid sinus mimicking intraosseous lesions of the skull base.

    Science.gov (United States)

    Jalali, Elnaz; Tadinada, Aditya

    2015-03-01

    Arrested pneumatization of the sphenoid sinus is a developmental variant that is not always well recognized and is often confused with other pathologies associated with the skull base. This report describes the case of a patient referred for cone-beam computed tomography (CBCT) imaging for dental implant therapy. CBCT demonstrated a well-defined incidental lesion in the left sphenoid sinus with soft tissue-like density and sclerotic borders with internal curvilinear opacifications. The differential diagnoses included intraosseous lipoma, arrested pneumatization of the sphenoid sinus, chondrosarcoma, chondroid chordoma, and ossifying fibroma. The radiographic diagnosis of arrested pneumatization was based on the location of the lesion, its well-defined nature, the presence of internal opacifications, and lack of expansion. Gray-scale CBCT imaging of the area demonstrated values similar to fatty tissue. This case highlighted the fact that benign developmental variants associated with the skull base share similar radiographic features with more serious pathological entities. PMID:25793186

  9. On the CT-diagnosis of optic nerve lesions. Differential diagnostic criteria

    International Nuclear Information System (INIS)

    Computed tomograms of 166 optic nerve lesions were analyzed: 97 were mainly orbital and 69 mainly intracranial. The criteria were clinical course, size, density and delineation of the optic nerve shadow, orbital and cerebral soft tissue abnormalities, and bony changes in the optic canal. Characteristic CT features are described of individual disease entities such as optic gliomas, optic nerve sheath meningiomas, neoplastic and inflammatory infiltrations. The differential diagnostic importance of individual CT criteria is evaluated and discussed. Simultaneous visualization of orbital and intracranial soft tissue changes as well as bony changes in the optic canal allow the location and identification of the majority of optic nerve lesions based on the criteria mentioned above, and optic nerve tumors can be differentiated. In 9 patients with optic neuritis due to clinically proven encephalitis and in 17 patients with total optic atrophy, no changes in the size of the optic nerve could be found. CT evaluation of the intraorbital portion of the optic nerve requires special examination techniques. Oblique computer reformations through the optic canal provide excellent visualization of bony changes in the optic canal. The exclusion of intracranial causes of optic nerve lesions requires intravenous injection of contrast material. (orig.)

  10. Model reactions for insect cuticle sclerotization: participation of amino groups in the cross-linking of Manduca sexta cuticle protein MsCP36.

    Science.gov (United States)

    Suderman, Richard J; Dittmer, Neal T; Kramer, Karl J; Kanost, Michael R

    2010-03-01

    Current theories of sclerotization center on protein cross-linking and dehydration as major factors in the hardening and stability of the insect cuticle. Several studies have reported the identification of catechol-amino acid adducts from sclerotizing cuticle involving histidine, lysine, and tyrosine, though there have been no reports of a catechol linked between two amino acid residues. Previously, we reported an in vitro model system for sclerotization and observed that stable protein oligomers were formed, presumably through cross-links with oxidized catecholamines [Insect Biochem. Mol. Biol. (2006) 36, 353-365]. Using site-directed mutagenesis we created a mutant lacking histidine, rMsCP36(H65A/H178A), to investigate the possible involvement of the two histidine residues of MsCP36 in cross-linking. Surprisingly, this alteration had little or no effect on the formation of protein oligomers as determined by SDS-PAGE analysis. Blocking of the free amino groups in lysyl side chains and the amino-terminus by succinylation diminished, but did not eliminate, cross-linking of either rMsCP36 or rMsCP36(H65A/H178A). We also examined the possibility that cross-linking was due to intermolecular dityrosine linkages. Immunoblot analysis utilizing a monoclonal antibody known to recognize peptidyl dityrosine indicated that dityrosyl cross-links were present. Taken together, these results indicate that lysyl residues are important for the cross-linking of the cuticle protein rMsCP36, but that additional residues other than histidine can also contribute. PMID:20219676

  11. Comparative study of notoungulate (Placentalia, Mammalia) bony labyrinths and new phylogenetically informative inner ear characters.

    Science.gov (United States)

    Macrini, Thomas E; Flynn, John J; Ni, Xijun; Croft, Darin A; Wyss, André R

    2013-11-01

    The phylogenetic relationships of notoungulates, an extinct group of predominantly South American herbivores, remain poorly resolved with respect to both other placental mammals and among one another. Most previous phylogenetic analyses of notoungulates have not included characters of the internal cranium, not least because few such features, including the bony labyrinth, have been described for members of the group. Here we describe the inner ears of the notoungulates Altitypotherium chucalensis (Mesotheriidae), Pachyrukhos moyani (Hegetotheriidae) and Cochilius sp. (Interatheriidae) based on reconstructions of bony labyrinths obtained from computed tomography imagery. Comparisons of the bony labyrinths of these taxa with the basally diverging notoungulate Notostylops murinus (Notostylopidae), an isolated petrosal from Itaboraí, Brazil, referred to Notoungulata, and six therian outgroups, yielded an inner ear character matrix of 25 potentially phylogenetically informative characters, 14 of them novel to this study. Two equivocally optimized character states potentially support a pairing of Mesotheriidae and Hegetotheriidae, whereas four others may be diagnostic of Notoungulata. Three additional characters are potentially informative for diagnosing more inclusive clades: one for crown Placentalia; another for a clade containing Kulbeckia, Zalambdalestes, and Placentalia; and a third for Eutheria (crown Placentalia plus stem taxa). Several other characters are apomorphic for at least one notoungulate in our study and are of potential interest for broader taxonomic sampling within Notoungulata to clarify currently enigmatic interrelationships. Measures of the semicircular canals were used to infer agility (e.g. capable of quick movements vs. lethargic movements) of these taxa. Agility scores calculated from these data generally corroborate interpretations based on postcranial remains of these or closely related species. We provide estimates of the low-frequency hearing limits in notoungulates based on the ratio of radii of the apical and basal turns of the cochlea. These limits range from 15?Hz in Notostylops to 149?Hz in Pachyrukhos, values comparable to the Asian elephant (Elephas maximus) and the California sea lion (Zalophus californianus) when hearing in air, respectively. PMID:24102069

  12. Epithelial myoepithelial carcinoma in nasal cavity with bony destruction: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Ho Jin; Lee, Byung Hoon; Hwang, Yoon Joon; Kim, Su Young [Dept. of Radiology, Ilsan Paik Hospital, Inje University School of Medicine, Goyang , (Korea, Republic of)

    2013-10-15

    Epithelial-myoepithelial carcinoma (EMC) is a rare tumor that commonly involves the salivary glands. EMC arising from the nasal cavity is one of the most unusual cases. We describe a case of a 48-year-old patient who is presented with bilateral nasal obstruction for several months. Multidetector computed tomography reveals expansile, well-defined, heterogeneous enhancing soft tissue masses filling the nasal cavity with bony destruction of hard palate and maxillary alveolar ridge. The carcinoma was histologically characterized by a mixture of trabecular structure with myoepithelial cells and ductal cells, which are confirmed by electron microscopy and immunohistochemistry.

  13. Model reactions for insect cuticle sclerotization: cross-linking of recombinant cuticular proteins upon their laccase-catalyzed oxidative conjugation with catechols.

    Science.gov (United States)

    Suderman, Richard J; Dittmer, Neal T; Kanost, Michael R; Kramer, Karl J

    2006-04-01

    The quinone-tanning hypothesis for insect cuticle sclerotization proposes that N-acylcatecholamines are oxidized by a phenoloxidase to quinones and quinone methides, which serve as electrophilic cross-linking agents to form covalent cross-links between cuticular proteins. We investigated model reactions for protein cross-linking that occurs during insect cuticle sclerotization using recombinant pupal cuticular proteins from the tobacco hornworm, Manduca sexta, fungal or recombinant hornworm laccase-type phenoloxidase, and the cross-linking agent precursor N-acylcatecholamines, N-beta-alanydopamine (NBAD) or N-acetyldopamine (NADA). Recombinant M. sexta pupal cuticular proteins MsCP36, MsCP20, and MsCP27 were expressed and purified to near homogeneity. Polyclonal antisera to these recombinant proteins recognized the native proteins in crude pharate brown-colored pupal cuticle homogenates. Furthermore, antisera to MsCP36, which contains a type-1 Rebers and Riddiford (RR-1) consensus sequence, also recognized an immunoreactive protein in homogenates of larval head capsule exuviae, indicating the presence of an RR-1 cuticular protein in a very hard, sclerotized and nonpigmented cuticle. All three of the proteins formed small and large oligomers stable to boiling SDS treatment under reducing conditions after reaction with laccase and the N-acylcatecholamines. The optimal reaction conditions for MsCP36 polymerization were 0.3mM MsCP36, 7.4mM NBAD and 1.0U/mul fungal laccase. Approximately 5-10% of the monomer reacted to yield insoluble oligomers and polymers during the reaction, and the monomer also became increasingly insoluble in SDS solution after reaction with the oxidized NBAD. When NADA was used instead of NBAD, less oligomer formation occurred, and most of the protein remained soluble. Radiolabeled NADA became covalently bound to the MsCP36 monomer and oligomers during cross-linking. Recombinant Manduca laccase (MsLac2) also catalyzed the polymerization of MsCP36. These results support the hypothesis that during sclerotization, insect cuticular proteins are oxidatively conjugated with catechols, a posttranslational process termed catecholation, and then become cross-linked, forming oligomers and subsequently polymers. PMID:16551549

  14. The relationship of transverse sinus stenosis to bony groove dimensions provides an insight into the aetiology of idiopathic intracranial hypertension

    Energy Technology Data Exchange (ETDEWEB)

    Connor, S.E.J.; Stewart, V.R.; O' Flynn, E.A.M. [King' s College Hospital, Neuroradiology Department, Ruskin Wing, London (United Kingdom); Siddiqui, M.A. [Southern General Hospital, Institute of Neurological Sciences, Glasgow (United Kingdom)

    2008-12-15

    Transverse sinus tapered narrowings are frequently identified in patients with idiopathic intracranial hypertension (IIH); however, it remains unclear whether they are primary stenoses or whether they occur secondary to raised cerebrospinal fluid pressure. Computed tomographic venography demonstrates both the morphology of the venous system and the adjacent bony grooves so it may provide an insight into the aetiology of these transverse sinus stenoses. Tapered transverse sinus narrowings (>50%) were studied in 19 patients without IIH and 14 patients with IIH. Computed tomography vascular studies were reviewed and the dimensions of the venous sinuses and bony grooves at the sites of maximum and minimum transverse sinus area dimensions were recorded. There was demonstrated to be a strong correlation of bony groove height with venous sinus height at the largest portions of the transverse sinus in both IIH patients and non-IIH subjects as well as at the transverse sinus narrowing in non-IIH subjects. There was a discordant relationship between bony groove height and venous sinus height at the site of transverse sinus stenoses in IIH patients. In 5/23 IIH transverse sinus stenoses, the bony groove height was proportionate to that seen in non-IIH subjects. There were a further 8/23 cases where the small or absent sinus was associated with an absent bony groove. Transverse sinus tapered narrowings in subjects without IIH and in the majority of patients with IIH were associated with proportionately small or absent grooves, and these are postulated to be primary or fixed. Some patients with IIH demonstrate tapered transverse sinus stenoses with disproportionately large bony grooves, suggesting a secondary or acquired narrowing. This implies a varied aetiology for the transverse sinus stenoses of IIH. (orig.)

  15. The relationship of transverse sinus stenosis to bony groove dimensions provides an insight into the aetiology of idiopathic intracranial hypertension

    International Nuclear Information System (INIS)

    Transverse sinus tapered narrowings are frequently identified in patients with idiopathic intracranial hypertension (IIH); however, it remains unclear whether they are primary stenoses or whether they occur secondary to raised cerebrospinal fluid pressure. Computed tomographic venography demonstrates both the morphology of the venous system and the adjacent bony grooves so it may provide an insight into the aetiology of these transverse sinus stenoses. Tapered transverse sinus narrowings (>50%) were studied in 19 patients without IIH and 14 patients with IIH. Computed tomography vascular studies were reviewed and the dimensions of the venous sinuses and bony grooves at the sites of maximum and minimum transverse sinus area dimensions were recorded. There was demonstrated to be a strong correlation of bony groove height with venous sinus height at the largest portions of the transverse sinus in both IIH patients and non-IIH subjects as well as at the transverse sinus narrowing in non-IIH subjects. There was a discordant relationship between bony groove height and venous sinus height at the site of transverse sinus stenoses in IIH patients. In 5/23 IIH transverse sinus stenoses, the bony groove height was proportionate to that seen in non-IIH subjects. There were a further 8/23 cases where the small or absent sinus was associated with an absent bony groove. Transverse sinus tapered narrowings in subjects without IIH and in the majority of patients with IIH were associatajority of patients with IIH were associated with proportionately small or absent grooves, and these are postulated to be primary or fixed. Some patients with IIH demonstrate tapered transverse sinus stenoses with disproportionately large bony grooves, suggesting a secondary or acquired narrowing. This implies a varied aetiology for the transverse sinus stenoses of IIH. (orig.)

  16. Sexual dimorphism of the bony labyrinth: a new age-independent method.

    Science.gov (United States)

    Osipov, Benjamin; Harvati, Katerina; Nathena, Despoina; Spanakis, Konstantinos; Karantanas, Apostolos; Kranioti, Elena F

    2013-06-01

    Currently in physical anthropology there is a need for reliable methods of sex estimation for immature individuals and highly fragmented remains. This study develops a sex estimation technique from discriminant function analysis of the bony labyrinth as it matures before puberty and can survive taphonomic conditions that would destroy most other skeletal material. The bony labyrinth contains the organs of hearing and balance. For this reason biologists and paleoanthropologists have undertaken research in this area to understand evolutionary changes in locomotion. Prior studies have found clear differences between species, but within-species variation has not been satisfactorily investigated. 3D segmentations of the left and right labyrinths of 94 individuals from a Cretan collection were generated and measured. Mean measurements of height, width, size, and shape indices were analyzed for sexual dimorphism, bilateral asymmetry, and measurement error. Significant sexual dimorphism was detected for several measurements. For sex estimation, the single best variable was the radius of curvature of the posterior semicircular canal, which achieved 76% accuracy. Two multivariate functions increased accuracy to 84%. Although these equations are less accurate than equations for complete long bones and crania, they appear to be as accurate as or better than other techniques for sexing immature individuals and temporal bones. PMID:23640711

  17. A clinical investigation of demineralized bone matrix putty for treatment of periodontal bony defects in humans.

    Science.gov (United States)

    Banjar, Arwa Ahmed; Mealey, Brian L

    2013-01-01

    The goal of this study was to evaluate the effectiveness of demineralized bone matrix (DBM) putty, consisting of demineralized human bone allograft matrix in a carrier of bovine collagen and alginate, for the treatment of periodontal defects in humans. Twenty subjects with at least one site having a probing depth ? 6 mm and radiographic evidence of bony defect depth > 3 mm were included. The infrabony defects were grafted with DBM putty bone graft. The following clinical parameters were assessed at baseline and 6 months posttreatment: probing depth (PD), gingival recession (GR), and clinical attachment level (CAL). Bone fill was evaluated using transgingival probing and standardized radiographs taken at baseline and 6 months posttreatment. The 6-month evaluation showed a significant PD reduction of 3.27 ± 1.67 mm and clinical attachment gain of 2.27 ± 1.74 mm. Bone sounding measurements showed a mean clinical bone defect fill of 2.93 ± 1.87 mm and a mean radiographic bone fill of 2.55 ± 2.31 mm. The use of DBM putty was effective for treatment of periodontal bony defects in humans. Significant improvement in CAL, PD, and bone fill was observed at 6 months compared to baseline. PMID:23998152

  18. A novel surface treatment for porous metallic implants that improves the rate of bony ongrowth.

    Science.gov (United States)

    Shannon, Fintan J; Cottrell, Jocelyn M; Deng, Xiang-Hua; Crowder, Katherine N; Doty, Stephen B; Avaltroni, Michael J; Warren, Russell F; Wright, Timothy M; Schwartz, Jeffrey

    2008-09-15

    Rapid implant fixation could prove beneficial in a host of clinical applications from total joint arthroplasty to trauma. We hypothesized that a novel self-assembled monolayer of phosphonate molecules (SAMP) covalently bonded to the oxide surface of titanium alloy would enhance bony integration. Beaded metallic rods were treated with one of three coatings: SAMP, SAMP + RGD peptide, or hydroxyapatite. Rods were inserted retrogradely into both distal femurs of 60 rabbits. Fifteen rabbits were sacrificed at 2, 4, 8, and 16 weeks. At each time, seven specimens for mechanical pull-out testing and three for histomorphometric analysis were available for each coating. At four weeks, both SAMP groups had significantly higher failure loads when compared to hydroxyapatite (p < 0.01). No significant differences were found among groups at other times, though the SAMP-alone group remained stronger at 16 weeks. Histology showed abundant new bone formation around all the three groups, though more enhanced formation was apparent in the two SAMP groups. With this novel treatment, with or without RGD, the failure load of implants doubled in half the time as compared with hydroxyapatite. Where early implant fixation is important, the SAMP treatment provides a simple, cost-effective enhancement to bony integration of orthopaedic implants. PMID:18041733

  19. Distinct focal lesions of the femoral head: imaging features suggesting an atypical and minimal form of bone necrosis

    International Nuclear Information System (INIS)

    Heading AbstractObjective. To document the imaging findings observed in patients with an unusual pattern of abnormality of the femoral head, most likely representing osteonecrosis.Design and patients. The imaging findings in 11 patients (10 men, 1 woman; age range 32-55 years) with a distinct lesion of the femoral head were reviewed with particular attention to the morphologic appearance, location, and extent of the lesion(s) in the proximal femur.Results. The 16 lesions identified in these patients extended to the subchondral area. Articular collapse was not evident in any hip. Radiography and CT showed areas of mixed bone sclerosis and osteolysis surrounded by sclerotic margins. On MR imaging, the signal intensity characteristics of the osseous lesion(s) were most commonly similar to those of fluid. Histopathologic findings, available in two hips, were typical of osteonecrosis. There was evidence of correlation of the site of the lesion with the known general distribution and anastomoses of arteries supplying the femoral head.Conclusion. A distinct, focal lesion of the femoral head is believed to represent an atypical form of bone necrosis. Its restriction to a small portion of the femoral head may relate to localized vascular anatomy. Recognition of the quite characteristic imaging findings can prevent misdiagnosis and may have implications for the prediction of the natural course of the disease. (orig.)

  20. Local phagocytic responses after murine infection with different forms of Fonsecaea pedrosoi and sclerotic bodies originating from an inoculum of conidiogenous cells.

    Science.gov (United States)

    Machado, Alexandre Paulo; Silva, Maria Regina Regis; Fischman, Olga

    2011-05-01

    Fonsecaea pedrosoi is an important causative agent of chromoblastomycosis (CBM) especially in humid areas of the world; however, little is known about the infective forms of this agent that cause CBM. The aim of this study was to investigate the murine tissue response to inoculation with different forms of F. pedrosoi and the morphological changes of the fungal cells in vivo. BALB/c mice were inoculated intraperitoneally with hyphae, conidia or conidiogenous cells and conidia (CCC) at a single site. In addition, the abdomen and footpads were infected subcutaneously with CCC. Fungal forms were inoculated at a final concentration of 1 × 10(6) cells. Hyphae and ungerminated conidia inocula could not be transformed into parasitic forms. In tissue, a great number of conidiogenous cells underwent transformation into sclerotic bodies, which were more resistant to phagocytes in vivo than conidia and hyphae. Clinical and mycological cure of animals infected with CCC was observed from the fourth to the sixth week of infection, while conidia and hyphae infections were faster and generally lasted 2 to 3 weeks. A high number of destructed conidia was observed intracellularly in macrophages. The migration of neutrophils to the inflammatory site seems important for microbicidal activity, particularly against hyphae. Our observations suggest that inocula with conidiogenous cells are associated with in vivo transformation into sclerotic bodies and that local immune response involved with host resistance to experimental F. pedrosoi-infection is primarily mediated by neutrophils as observed in histological sections. PMID:19925569

  1. Spinal metastatic lesion in cancer patients. Investigation based on statistical analysis by bone scintigrams

    International Nuclear Information System (INIS)

    In a series of 2,216 cancer patients undergoing bone scintigraphy after diagnosis of the primary malignant tumor, 558 (25.2%) were found to have abnormal vertebral accumulation of radioactivity during the clinical course. Abnormal radioactivity in the vertebrae was frequently noted in patients with prostatic and renal cancer. The lumbar vertebrae were the most frequent sites but the cervical vertebrae were also affected with prostatic cancer, the thoracic vertebrae with lung and prostatic cancer, the lumbar vertebrae with breast and prostatic cancer and the sacral vertebrae with uterine cervical and prostatic cancer. Of the 558 patients with abnormal spinal radioactivity, 221 were examined by CT scan; the accumulated radioactivity was identified as a metastatic lesion in 170 patients (76.9%). Abnormal radioactivity was identified as a metastatic lesion most often in lung cancer patients. The CT-diagnosed metastases were classified into 3 types: sclerotic (51 patients, 30.0%), osteolytic (112, 65.9%), and mixed (46, 27.1%). The sclerotic type was relatively frequent in uterine cervical cancer, less frequent in lung cancer, and not seen in head and neck or renal cancer patients. The osteolytic type was relatively frequent in lung and renal cancer and less frequent in uterine cervical and prostatic cancer patients. Of the patients with CT-diagnosed vertebral metastasis, 87.3% survived for 3 months and 66.2% for 6 months after the detection of abnormal bone scintigraphy. detection of abnormal bone scintigraphy. Survival was shorter in patients with lung or gastrointestinal cancer than in those with other types of tumors. Since the pathology of vertebral metastasis of malignant tumors differs according to the primary lesion, the metastatic nature must be considered in the choice of treatment. (author)

  2. Reconstruction of bony facial contour deficiencies with polymethylmethacrylate implants: case report

    Scientific Electronic Library Online (English)

    Ruy C. C., Abdo Filho; Thais M., Oliveira; Natalino, Lourenço Neto; Carla, Gurgel; Ruy C.C., Abdo.

    2011-08-01

    Full Text Available SciELO Brazil | Language: English Abstract in english Facial trauma can be considered one of the most serious aggressions found in the medical centers due to the emotional consequences and the possibility of deformity. In craniofacial surgery, the use of autologous bone is still the first choice for reconstructing bony defects or irregularities. When t [...] here is a shortage of donor bone or a patient refuses an intracranial operation, alloplastic materials such as polymethylmethacrylate (PMMA) can be used. The PMMA prosthesis can be pre-fabricated, bringing advantages such as reduction of surgical time, easy technical handling and good esthetic results. This paper describes the procedures for rehabilitating a patient with PMMA implants in the region of the face, recovering the facial contours and esthetics of the patient.

  3. Crouzon syndrome with bony upper airway obstruction: case report and review literature.

    Science.gov (United States)

    Gothwal, Sunil; Nayan, Swati; Kumar, Jagdish

    2014-08-01

    Crouzon syndrome is a rare genetic disorder. It is inherited as an autosomal dominant pattern. Mutations in the FGFR2 gene are known to cause Crouzon syndrome. Craniofacial abnormalities are common at birth and may progress with time. The severity of these signs and symptoms varies among affected children. A full term, large for date, male baby was delivered to a gravida 2 mother by cesarean section having facial dimorphism suggestive of Crouzon syndrome. Genetic team confirmed the diagnosis. Baby had severe respiratory distress. On work up, upper bony airway narrowing was found (diameter 3 mm). Later on, baby was operated for the same. Baby is asymptomatic now and doing well up to 2 months of follow-up. Management of Crouzon disease is multidisciplinary and early diagnosis has prime importance. Follow-up must ensure late features like hearing problems, vision problems, dental problems, intelligence, cranial synostosis, and upper airway problems. PMID:24828762

  4. A tomographic study of positional and bony changes in the temporomandibular joint following orthognathic surgery

    Energy Technology Data Exchange (ETDEWEB)

    Song, Nam Kyu; Kim Min Suk; Koh, Kwang Joon [Dept. of Oral Radiology, College of Dentistry, Chonpook National University, Chonju (Korea, Republic of)

    1992-08-15

    The purpose of this study was to aid in the evaluation of prognosis of temporomandibular joint following orthognathic surgery. For this study, 20 patients (40 TMJ) who undergone orthognathic surgery were examined. Preoperative and postoperative tomograms of TMJ were taken. And the subjects were divided into 3 groups according to postoperative periods. The obtained results were as follows : 1. There were no significant differences between preoperative and postoperative changes in joint spaces in each group and between groups (P<0.05). 2. There were no significant differences between preoperative and postoperative ratio of joint spaces (P<0.05).3. There were no significant differences between preoperative and postoperative changes in the range of motion of condylar head (P<0.05). 4. The bony changes of condylar head were observed in 14 (35%) condyles (6 erosion, 2 flattening, 5 double contour, 1 osteophyte).

  5. A tomographic study of positional and bony changes in the temporomandibular joint following orthognathic surgery

    International Nuclear Information System (INIS)

    The purpose of this study was to aid in the evaluation of prognosis of temporomandibular joint following orthognathic surgery. For this study, 20 patients (40 TMJ) who undergone orthognathic surgery were examined. Preoperative and postoperative tomograms of TMJ were taken. And the subjects were divided into 3 groups according to postoperative periods. The obtained results were as follows : 1. There were no significant differences between preoperative and postoperative changes in joint spaces in each group and between groups (P<0.05). 2. There were no significant differences between preoperative and postoperative ratio of joint spaces (P<0.05).3. There were no significant differences between preoperative and postoperative changes in the range of motion of condylar head (P<0.05). 4. The bony changes of condylar head were observed in 14 (35%) condyles (6 erosion, 2 flattening, 5 double contour, 1 osteophyte).

  6. Reconstruction of bony facial contour deficiencies with polymethylmethacrylate implants: case report

    Directory of Open Access Journals (Sweden)

    Ruy C. C. Abdo Filho

    2011-08-01

    Full Text Available Facial trauma can be considered one of the most serious aggressions found in the medical centers due to the emotional consequences and the possibility of deformity. In craniofacial surgery, the use of autologous bone is still the first choice for reconstructing bony defects or irregularities. When there is a shortage of donor bone or a patient refuses an intracranial operation, alloplastic materials such as polymethylmethacrylate (PMMA can be used. The PMMA prosthesis can be pre-fabricated, bringing advantages such as reduction of surgical time, easy technical handling and good esthetic results. This paper describes the procedures for rehabilitating a patient with PMMA implants in the region of the face, recovering the facial contours and esthetics of the patient.

  7. A clinico-radiologic study of bony remodeling of the fractured condyles in children

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jeong Shin; Park, Chang Seo [Department of Dentistry, The Graduate School, Yonsei University, Seoul (Korea, Republic of)

    1995-08-15

    Bony remodeling pattern of condyle fractures in children are different from in adult for growing of condyle, also might affect treatment and prognosis of the condyle fracture. Subjects of this clinical and radiologic study were 26 temporomandibular joints diagnosed as condyle fracture in 23 patients under 15 years old age, They were treated with conservative method at Dental Hospital of Yonsei University from Jan., 1986 to Oct., 1994. Bony remodeling related with fracture pattern was evaluated. The results obtained are as follows: 1. The ratio of male to female in patients with condyle fracture was 1 : 0.9 and the difference of sex ratio was not noted. Comparing with preschool-age group and school-age group, age frequency was higher in preschool-age group (83%). 2. Fallen down (54%) was the most frequent cause of condyle fractures. Traffic accident and slip down were followed. 3. The most common clinical sign of condyle fractures was tenderness to palpation (19 cases). Mouth opening limitation (17 cases), swelling (7 cases), malocclusion (3 cases) were next in order. 4. According to sites of condyle fractures, unilateral fractures were in 20 patients and bilateral fractures in 3 patients, therefore total 23 patients-26 cases of condyle fracture were observed. According to fracture distribution, condyle fractures were in 10 patients (44%). Condyle fractures with symphysis fracture (9 patients, 39%), condyle fractures with ascending ramus fracture (2 patients, 9%), condyle fracture with mandibular body fracture (1 patient, 4%), and condyle fractures with mandibular angle fracture (1 patient, 4%) were followed. 5. In displacement pattern of fractured fragment of mandibular condyle, displacement (17 cases, 66%) was most common. Dislocation (5 cases, 19%) and deviation (4 cases, 15%) were next in order. 6. During the observation period of fractured condyles, remodeling patterns of fracture sites related with articular fossa were observed with usual congealer shape in 23 cases and with prominently different shape in 3 cases.

  8. Bony anatomic variants of the paranasal sinuses and nasal septum. Comparison between normal and chronic sinusitis

    International Nuclear Information System (INIS)

    Agger nasi cells, concha bullosa, Haller's cells and deviation of the nasal septum were evaluated with coronal plane computerized tomographic (CT) scanning in patients with normal paranasal sinuses (44 cases) and patients with chronic sinusitis (91 cases). Agger nasi cells were present in 68 (50.4%) of cases. Concha bullosa was present in 39 cases (28.9%), Haller's cells were present in 15 cases (11.1%), and deviation of the nasal septum was present in 64 cases (47.4%). Haller's cells were more commonly encountered in cases with normal paranasal sinuses (20.5%), than in cases with chronic sinusitis (6.6%). Other bony structural variations were noted at a similar frequency in both groups. Each sinus (frontal sinus, ethmoid sinus, maxillary sinus and sphenoid sinus) of patients with chronic sinusitis was then evaluated separately. Agger nasi cells were observed more frequently in chronic frontal sinusitis and ethmoid sinusitis compared to subjects with normal sinuses. Concha bullosa was observed more frequently in cases with normal frontal sinuses and ethmoid sinuses than in cases of chronic frontal sinusitis and ethmoid sinusitis. Haller's cells and deviation of the nasal septum were observed at a similar frequency in both groups. Based on these results, it was thought that these bony structural variations sometimes disturbed the reopening of the normal ventilation and drainage pathways of the paranasal sinuses at the stage of acute sinusitis. These nasal ventilatory dacute sinusitis. These nasal ventilatory disturbances may predispose the patient to recurrent sinusitis, and may finally result in chronic sinusitis. (author)

  9. Description of patients with bony tumors treated with prosthesis in reconstruction in the Servicio de Ortopedia at the Hospital Rafael Angel Calderon Guardia 2000-2006

    International Nuclear Information System (INIS)

    The use of prosthesis in reconstruction for the management of extensive tumor bone lesions. The study of six patients treated is performed at the Hospital Rafael Angel Calderon Guardia, who were treated for aggressive tumors in the period 2001-2006. Bony tumors are conceptualized, as well as fundamental aspects of cell biology in its development and the classification of the same. Also, relevant information is included with relation to the most frequent indications and possible treatments. In all six cases was placed the rescue prosthesis, four of them has been obtained excellent results. Limb amputation has been the only alternative until the decade of the 70 and survival rates with this treatment were 10 to 20% survival at 5 years. Today, with advances in chemotherapy and limb salvage prosthesis, patients without metastases at diagnosis have a survival of 65 to 75% at five years. The study has made it possible to simultaneously to analyze some aspects of care to these patients; such as: time of biopsy, time of diagnosis, time of initiation of chemotherapy and surgical intervention time. Through this study has concluded that when referring to a malignant tumor of bone is absolutely essential that the process of diagnosis and initiation of treatment of limb salvage surgery are addressed as soon as possible. Finally, some recommendations are raised to strengthen the treatment of malignant tumors in the Hospital Rafael Angel Calderon Guardia. (author)deron Guardia. (author)

  10. A dose-response relationship for time to bone pain resolution after stereotactic body radiotherapy (SBRT) for renal cell carcinoma (RCC) bony metastases

    International Nuclear Information System (INIS)

    Background. To investigate the utility of stereotactic body radiotherapy (SBRT) in the treatment of painful renal cell carcinoma (RCC) bone metastases, and for a possible dose effect on time to symptom relief. Material and methods. Eighteen patients with 24 painful osseous lesions from metastatic RCC were treated with SBRT. The most common treatment regimens were 24 Gy in 3 fractions and 40 Gy in 5 fractions. The times from treatment to first reported pain relief and time to symptom recurrence were evaluated. Median follow-up was 38 weeks (1-156 weeks). Results. Seventy-eight percent of all patients had pain relief. Patients treated with a BED > 85 Gy achieved faster and more durable pain relief compared to those treated with a BED < 85 Gy. There was decrease in time to pain relief after a change in treatment regimen to 8 Gy x 5 fractions (BED = 86). There was only one patient with grade 1 skin toxicity. No neurological or other toxicity was observed. Conclusions. SBRT can safely and effectively treat painful RCC bony metastases. There appears to be a relationship between radiation dose and time to stable pain relief

  11. A dose-response relationship for time to bone pain resolution after stereotactic body radiotherapy (SBRT) for renal cell carcinoma (RCC) bony metastases

    Energy Technology Data Exchange (ETDEWEB)

    Jhaveri, Pavan M. [Dept. of Radiology, Section of Radiation Oncology, Baylor College of Medicine, Houston (United States); Teh, Bin S.; Paulino, Arnold C.; Blanco, Angel I.; Butler, E. Brian [Dept. of Radiation Oncology, The Methodist Hospital/The Methodist Hospital Research Inst., Houston (United States)], email: bteh@tmhs.org; Lo, Simon S. [Dept. of Radiation Oncology, Univ. Hospitals Seidman Cancer Center, Case Western Reserve Univ., Cleveland (United States); Amato, Robert J. [Dept. of Internal Medicine, Div. of Oncology, Univ. of Texas Health Sciences Center, Houston (United States)

    2012-05-15

    Background. To investigate the utility of stereotactic body radiotherapy (SBRT) in the treatment of painful renal cell carcinoma (RCC) bone metastases, and for a possible dose effect on time to symptom relief. Material and methods. Eighteen patients with 24 painful osseous lesions from metastatic RCC were treated with SBRT. The most common treatment regimens were 24 Gy in 3 fractions and 40 Gy in 5 fractions. The times from treatment to first reported pain relief and time to symptom recurrence were evaluated. Median follow-up was 38 weeks (1-156 weeks). Results. Seventy-eight percent of all patients had pain relief. Patients treated with a BED > 85 Gy achieved faster and more durable pain relief compared to those treated with a BED < 85 Gy. There was decrease in time to pain relief after a change in treatment regimen to 8 Gy x 5 fractions (BED = 86). There was only one patient with grade 1 skin toxicity. No neurological or other toxicity was observed. Conclusions. SBRT can safely and effectively treat painful RCC bony metastases. There appears to be a relationship between radiation dose and time to stable pain relief.

  12. Evidence for the formation of a quinone methide during the oxidation of the insect cuticular sclerotizing precursor 1,2-dehydro-N-acetyldopamine.

    Science.gov (United States)

    Sugumaran, M; Semensi, V; Kalyanaraman, B; Bruce, J M; Land, E J

    1992-05-25

    1,2-Dehydro-N-acetyldopamine (dehydro-NADA) is an important catecholamine derivative involved in the cross-linking of insect cuticular components during sclerotization. Since sclerotization is a vital process for the survival of insects, and is closely related to melanogenesis, it is of interest to unravel the chemical mechanisms participating in this process. The present paper reports on the mechanism by which dehydro-NADA is oxidatively activated to form reactive intermediate(s) as revealed by pulse radiolysis, electron spin resonance spectroscopy, high performance liquid chromatography, and ultraviolet-visible spectroscopic analysis. Pulse radiolytic one-electron oxidation of dehydro-NADA by N3. (k = 5.3 x 10(9) M-1 s-1) or Br2.- (k = 7.5 x 10(8) M-1 s-1) at pH6 resulted in the rapid generation of the corresponding semiquinone radical, lambda max 400 nm, epsilon = 20,700 M-1 cm-1. This semiquinone decayed to form a second transient intermediate, lambda max 485 nm, epsilon = 8000 M-1 cm-1, via a second order disproportionation process, k = 6.2 x 10(8) M-1 s-1. At pH 6 in the presence of azide, the first order decay of this second intermediate occurred over milliseconds; the rate decreases at higher pH. At pH 6 in the presence of bromide, the intermediate decayed much more slowly over seconds, k = 0.15 s-1. Under such conditions, the dependence of the first order decay constant upon parent dehydro-NADA concentration led to a second order rate constant of 8.5 x 10(2) M-1 s-1 for reaction of the intermediate with the parent, probably to form benzodioxan "dimers." (The term dimer is used for convenience; the products are strictly bisdehydrodimers of dehydro-NADA (see "Discussion" and Fig. 11)) Rate constants of 5.9 x 10(5), 4.5 x 10(5), 2.8 x 10(4) and 3.5 x 10(4) M-1 s-1 were also obtained for decay of the second intermediate in the presence of cysteine, cysteamine, o-phenylenediamine, and p-aminophenol, respectively. By comparison with the UV-visible spectroscopic properties of the two-electron oxidized species derived from dehydro-NADA and from 1,2-dehydro-N-acetyldopa methyl ester, it is concluded that the transient intermediate exhibiting absorbance at 485 nm is the quinone methide tautomer of the o-quinone of dehydro-NADA. Sclerotization of insect cuticle is discussed in the light of these findings. PMID:1316899

  13. Tumefactive demyelinating lesions

    Energy Technology Data Exchange (ETDEWEB)

    Dagher, A.P. [Thomas Jefferson Univ. Hospital, Philadelphia, PA (United States). Div. of Neuroradiology; Smirniotopoulos, J. [Thomas Jefferson Univ. Hospital, Philadelphia, PA (United States). Div. of Neuroradiology]|[Armed Forces Inst. of Pathology, Washington, DC (United States). Dept. of Radiological Pathology

    1996-08-01

    We studied 21 cases of pathologically confirmed tumefactive demyelinating lesions and reviewed the spectrum of tumefactive demyelinating lesions in the literature. Radiological features and clinical data were reviewed to characterize the lesions as consistent with a known demyelinating disease, most notably multiple sclerosis. Atypical clinical or radiological features (other than tumefaction) were noted. Most lesions were part of a clinical and/or radiological picture consistent with multiple sclerosis. No case strongly suggestive of variants or related diseases, such as Schilder`s disease or Balo`s concentric sclerosis, were found. There was one case suggestive of acute disseminated encephalomyelitis. Features which help distinguish the lesions from tumour are discussed. (orig.)

  14. Tumefactive demyelinating lesions

    International Nuclear Information System (INIS)

    We studied 21 cases of pathologically confirmed tumefactive demyelinating lesions and reviewed the spectrum of tumefactive demyelinating lesions in the literature. Radiological features and clinical data were reviewed to characterize the lesions as consistent with a known demyelinating disease, most notably multiple sclerosis. Atypical clinical or radiological features (other than tumefaction) were noted. Most lesions were part of a clinical and/or radiological picture consistent with multiple sclerosis. No case strongly suggestive of variants or related diseases, such as Schilder's disease or Balo's concentric sclerosis, were found. There was one case suggestive of acute disseminated encephalomyelitis. Features which help distinguish the lesions from tumour are discussed. (orig.)

  15. Periodontal bone lesions

    International Nuclear Information System (INIS)

    In the course of life the periodontum is subject to changes which may be physiological or pathological. Intraoral radiographs give insight into the hard structures of the dentomaxillar region and provides information on lesions in the bone of the periodontum in that they show radiopacities and radiolucencies caused by such lesions. In this thesis the relation is investigated between the true shape and dimensions of periodontal bone lesions and their radiographic images. A method is developed and tested of making standardized and reproducible radiographs suitable for longitudinal studies of periodontal lesions. Also the possibility is demonstrated of an objective and reproducible interpretation of radiographic characteristics of periodontal bone lesions. (Auth.)

  16. Pre-transplantation risk factors to develop sclerotic chronic GvHD after allogeneic HSCT: a multicenter retrospective study from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC).

    Science.gov (United States)

    Detrait, M Y; Morisset, S; Peffault de Latour, R; Yakoub-Agha, I; Crocchiolo, R; Tabrizi, R; Bay, J-O; Chevalier, P; Barraco, F; Raus, N; Vigouroux, S; Magro, L; Mohty, M; Milpied, N; Blaise, D; Socié, G; Michallet, M

    2015-02-01

    Sclerotic chronic GvHD (cGvHD) is one of the most severe complications after allo-hematopoietic stem cell transplantation (HSCT). Risk factors associated with this complication remain not very well defined. With the aim to define a pre-transplantation risk profile, we have conducted a French retrospective analysis in 705 consecutive patients between 2005 and 2010. Analyses to determine pre-transplantation risk factors included as variables: patient and donor age, kind of donor, HLA matching, ABO matching, sex-matching, diagnosis, stem cell source, gender, GvHD prophylaxis and antithymocyte globulin (ATG) in the conditioning regimen. The cumulative incidence of sclerotic cGvHD was 18% (95% CI, 16.6-19.6) 3 years after onset of cGvHD. In univariate analysis, we found a significantly lower number of sclerotic cGvHD form in patients transplanted from cord blood cells (P=0.0021), in patients with a one mismatched donor (P=0.041) and in patients who had received ATG in the conditioning regimen (P=0.002). In multivariate analysis, factors associated with an increased risk of sclerotic cGvHD were young patient age, multiple myeloma and PBSC as the stem cell source. ATG in conditioning regimen and cord blood unit as the stem cell source were associated with a lower risk. PMID:25365068

  17. Quantitative computed tomography as a test of endurance for evaluation of bony plates; Utilizacao da tomografia computadorizada quantitativa como teste de resistencia para avaliacao de placas osseas

    Energy Technology Data Exchange (ETDEWEB)

    Melo Filho, E.V.; Costa, L.A.V.S.; Oliveira, D.C. [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil); Freitas, P.M.C. [Escola de Veterinaria - Universidade Federal de Minas Gerais - Belo Horizonte, MG (Brazil); Teixeira, M.W.; Costa, F.S. [Universidade Federal Rural de Pernambuco - Recife, PE (Brazil)

    2012-06-15

    Quantitative computed tomography was used to determine the radiodensity of bony plates. The CT scans provided information regarding radiodensity of bony plates and allowed to verify the uniformity of bone mineral density in their scope. The proposed methodology should be considered as another tool for determining the resistance of these biomaterials. (author)

  18. {sup 99m}Tc-HDP Bone Scintigraphy Finding of Metastatic Renal Cell Carcinoma Bone Lesion Changed from Hot to Cold Lesion: Comparing with {sup 18}F-FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Young Duk; Kim, Seong Min; Kim, Kun Ho [Chungnam National University Hospital, Daejeon (Korea, Republic of)

    2009-12-15

    A 26-year-old man with renal cell carcinoma underwent {sup 99m}Tc-HDP bone scintigraphy for detecting bony metastasis after left total nephrectomy for renal cell carcinoma. {sup 99m}Tc-HDP bone scintigraphy showed small hot lesion in the first lumbar spine. About 12 months later, he underwent spinal MRI for lower back pain. A large mass was seen around spinous process of the first lumbar spine (L1) on spinal MRI and confirmed as metastatic renal cell carcinoma by bone biopsy. {sup 99m}Tc-HDP bone scintigraphy and {sup 18}F-FDG PET/CT were underwent for further evaluation. {sup 99m}Tc-HDP bone scintigraphy showed cold lesion in the first lumbar spine which was initially hot and newly developed hot lesion in the twelfth thoracic spine, and which were shown as hypermetabolic lesions in {sup 18}F-FDG PET/CT. We report a case of bony metastasis from renal cell carcinoma which is changed from hot lesion to cold lesion in {sup 99m}Tc-HDP bone scintigraphy and compare with {sup 18}F-FDG PET/CT.

  19. N-acetyldopamine quinone methide/1,2-dehydro-N-acetyl dopamine tautomerase. A new enzyme involved in sclerotization of insect cuticle.

    Science.gov (United States)

    Saul, S J; Sugumaran, M

    1989-09-25

    The enzyme system causing the side chain desaturation of the sclerotizing precursor, N-acetyldopamine (NADA), was solubilized from the larval cuticle of Sarcophaga bullata and resolved into three components. The first enzyme, phenoloxidase, catalyzed conversion of NADA to NADA quinone and provided it for the second enzyme (NADA quinone isomerase), which makes the highly unstable NADA quinone methide. Quinone methide was hydrated rapidly and nonenzymatically to form N-acetylnorepinephrine. In addition, it also served as the substrate for the last enzyme, quinone methide tautomerase, which converted it to 1,2-dehydro-NADA. Reconstitution of NADA side chain desaturase activity was achieved by mixing the last enzyme fraction with NADA quinone isomerase, obtained from the hemolymph of the same organism, and mushroom tyrosinase. Therefore, NADA side chain desaturation observed in insects is caused by the combined action of three enzymes rather than the action of a single specific NADA desaturase, as previously thought. PMID:2507358

  20. Unusual Malignant Breast Lesions

    Directory of Open Access Journals (Sweden)

    D. Farrokh

    2007-05-01

    Full Text Available Numerous unusual benign and malignant breast le-sions may be seen occasionally or rarely. Some of these lesions are distinctive and easily recognized be-cause of diagnostic clinical or radiographic criteria such as inflammatory carcinoma or Paget's disease, which are primarily a clinical diagnosis. Most of the unusual malignant breast lesions have no specific di-agnostic signs and may show the mammographic or ultrasonic findings of benign lesions. Although most radiologists may never see many of the unusual ma-lignant breast tumors, but it is important to be aware of these malignant lesions. In this article, we will present our 10-years experi-ence about unusual malignant breast lesions that in-clude breast sarcoma, phylloides tumor, Inflamma-tory carcinoma, intracystic carcinoma, Paget's dis-ease, primary lymphoma of the breast, breast metas-tasis and breast carcinoma in women less than 25 years old.

  1. Two-year clinical evaluation of three adhesive systems in non-carious cervical lesions

    Directory of Open Access Journals (Sweden)

    Evrim Eliguzeloglu Dalkilic

    2012-04-01

    Full Text Available OBJECTIVES: Adhesive systems are continuously being introduced to Dentistry, unfortunately often without sufficient clinical validation. The aim of this study was to evaluate the clinical performance of cervical restorations done with three different adhesive systems. MATERIAL AND METHODS: 158 non-carious cervical lesions of 23 patients were restored with a nanofilled composite resin (Filtek Supreme, 3M/ESPE combined with Single Bond (3M/ESPE, group SI, Clearfil SE (Kuraray Medical Inc., group CL and Xeno III (De Trey Dentsply, group XE. In groups SI-B, CL-B and XE-B, the outer surface of the sclerotic dentin was removed by roughening with a diamond bur before application of the respective adhesive systems. In groups CL-BP and XE-BP, after removal of the outer surface of the sclerotic dentin with the bur, the remaining dentin was etched with 37% phosphoric acid and the self-etch adhesive systems Clearfil SE and Xeno III were applied, respectively. Lesions were evaluated at baseline, and restorations after 3 months, 1 year and 2 years using modified USPHS criteria. RESULTS: After 2 years, no significant difference was found between the retention rates of the groups (p >0.05. Although groups CL and SI showed significantly better marginal adaptation than group XE (p0.05. After 2 years no significant difference was observed among the marginal staining results of all groups (p>0.05. CONCLUSION: Although all adhesive systems showed similar retention rates, Clearfil SE and Single Bond showed better marginal adaptation than Xeno III after 2 years of follow-up.

  2. Two-year clinical evaluation of three adhesive systems in non-carious cervical lesions

    Scientific Electronic Library Online (English)

    Evrim Eliguzeloglu, Dalkilic; Huma, Omurlu.

    2012-04-01

    Full Text Available SciELO Brazil | Language: English Abstract in english OBJECTIVES: Adhesive systems are continuously being introduced to Dentistry, unfortunately often without sufficient clinical validation. The aim of this study was to evaluate the clinical performance of cervical restorations done with three different adhesive systems. MATERIAL AND METHODS: 158 non-c [...] arious cervical lesions of 23 patients were restored with a nanofilled composite resin (Filtek Supreme, 3M/ESPE) combined with Single Bond (3M/ESPE, group SI), Clearfil SE (Kuraray Medical Inc., group CL) and Xeno III (De Trey Dentsply, group XE). In groups SI-B, CL-B and XE-B, the outer surface of the sclerotic dentin was removed by roughening with a diamond bur before application of the respective adhesive systems. In groups CL-BP and XE-BP, after removal of the outer surface of the sclerotic dentin with the bur, the remaining dentin was etched with 37% phosphoric acid and the self-etch adhesive systems Clearfil SE and Xeno III were applied, respectively. Lesions were evaluated at baseline, and restorations after 3 months, 1 year and 2 years using modified USPHS criteria. RESULTS: After 2 years, no significant difference was found between the retention rates of the groups (p >0.05). Although groups CL and SI showed significantly better marginal adaptation than group XE (p0.05). After 2 years no significant difference was observed among the marginal staining results of all groups (p>0.05). CONCLUSION: Although all adhesive systems showed similar retention rates, Clearfil SE and Single Bond showed better marginal adaptation than Xeno III after 2 years of follow-up.

  3. Radiotherapy for bony manifestations of Langerhans Cell Histiocytosis. Review and proposal for an international registry

    International Nuclear Information System (INIS)

    Purpose: to examine the role of radiotherapy (RT) in adult Langerhans Cell Histiocytosis (LCH) for osseous manifestations, to define open questions regarding RT, and to develop recommendations for the clinical decision-making and problem-solving process. Material and methods: a literature review using different medical databases was conducted including the last 3 decades, and resulting questions regarding the use of ionizing radiation were systematically compiled. Results: the literature review revealed a local control rate of 96% (93% complete remissions) in patients with osseous single-system disease and of 92% (76% complete remissions) in patients with bony involvement in multi-system disease. To increase our knowledge, a prospective registry has been developed to allow a differentiated analysis of RT outcome and definition of potential prognostic factors. Conclusion: ionizing radiation can be successfully applied as a single treatment or in combination with other therapies for osseous manifestations of LCH. It leads to high remission and local control rates. Nevertheless, many open questions still exist. A prospective clinical registry is proposed to define the exact role of RT in this disease and to develop future interdisciplinary treatment guidelines. (orig.)

  4. Leczenie farmakologiczne chorych na nawrotowe idiopatyczne zapalenie przedniego odcinka b?ony naczyniowej oka

    Directory of Open Access Journals (Sweden)

    Jerzy Szaflik

    2011-12-01

    Full Text Available Nawrotowe zapalenie przedniego odcinka b?ony naczyniowej oka(ZPOBN to choroba autoimmunologiczna, która u ok. 20% chorychdoprowadza do trwa?ego ci??kiego upo?ledzenia widzenia lub ?lepotyi, co z tego wynika, ci??kiego kalectwa i istotnego pogorszeniajako?ci ?ycia. Dlatego oprócz intensywnego leczenia fazy ostrejzapalenia i jej powik?a? bardzo wa?ne jest leczenie przewlek?e wceluutrzymania remisji w mo?liwie jak najd?u?szym czasie. A? u 50%chorych na nawrotowe ZPOBN nie udaje si? potwierdzi? wspó?istnienia?adnej choroby uk?adowej. Sytuacja ta, okre?lana mianemidiopatycznego ZPOBN (IZPOBN, stwarza du?e problemy w doborzestrategii terapeutycznej. Tym niemniej uwa?a si?, ?e IZPOBN mo?eby? pierwszym, zwiastunowym objawem spondyloartropatii, którynawet o kilkadziesi?t lat mo?e wyprzedza? pojawienie si? objawówtypowych dla tego zespo?u chorobowego. Dotychczas na tematskuteczno?ci terapii IZPOBN lekami z grupy leków przeciwreuma -tycz nych, które modyfikuj? przebieg tej choroby, opublikowanojedynie pojedyncze doniesienia uwzgl?dniaj?ce obserwacje ma?ychgrup pacjentów.Przedstawione w niniejszym artykule zalecenia do leczenia systemowegoIZPOBN zosta?y opracowane na podstawie do?wiadcze?o?rodków klinicznych, w których praktykuj? autorzy artyku?u, orazanalizy dost?pnych opracowa? naukowych.

  5. Automated bony region identification using artificial neural networks: reliability and validation measurements

    International Nuclear Information System (INIS)

    The objective was to develop tools for automating the identification of bony structures, to assess the reliability of this technique against manual raters, and to validate the resulting regions of interest against physical surface scans obtained from the same specimen. Artificial intelligence-based algorithms have been used for image segmentation, specifically artificial neural networks (ANNs). For this study, an ANN was created and trained to identify the phalanges of the human hand. The relative overlap between the ANN and a manual tracer was 0.87, 0.82, and 0.76, for the proximal, middle, and distal index phalanx bones respectively. Compared with the physical surface scans, the ANN-generated surface representations differed on average by 0.35 mm, 0.29 mm, and 0.40 mm for the proximal, middle, and distal phalanges respectively. Furthermore, the ANN proved to segment the structures in less than one-tenth of the time required by a manual rater. The ANN has proven to be a reliable and valid means of segmenting the phalanx bones from CT images. Employing automated methods such as the ANN for segmentation, eliminates the likelihood of rater drift and inter-rater variability. Automated methods also decrease the amount of time and manual effort required to extract the data of interest, thereby making the feasibility of patient-specific modeling a reality. (orig.)

  6. Automated bony region identification using artificial neural networks: reliability and validation measurements

    Energy Technology Data Exchange (ETDEWEB)

    Gassman, Esther E.; Kallemeyn, Nicole A.; DeVries, Nicole A.; Shivanna, Kiran H. [The University of Iowa, Department of Biomedical Engineering, Seamans Center for the Engineering Arts and Sciences, Iowa City, IA (United States); The University of Iowa, Center for Computer-Aided Design, Iowa City, IA (United States); Powell, Stephanie M. [The University of Iowa, Department of Biomedical Engineering, Seamans Center for the Engineering Arts and Sciences, Iowa City, IA (United States); University of Iowa Hospitals and Clinics, The University of Iowa, Department of Radiology, Iowa City, IA (United States); Magnotta, Vincent A. [The University of Iowa, Department of Biomedical Engineering, Seamans Center for the Engineering Arts and Sciences, Iowa City, IA (United States); The University of Iowa, Center for Computer-Aided Design, Iowa City, IA (United States); University of Iowa Hospitals and Clinics, The University of Iowa, Department of Radiology, Iowa City, IA (United States); Ramme, Austin J. [University of Iowa Hospitals and Clinics, The University of Iowa, Department of Radiology, Iowa City, IA (United States); Adams, Brian D. [The University of Iowa, Department of Biomedical Engineering, Seamans Center for the Engineering Arts and Sciences, Iowa City, IA (United States); University of Iowa Hospitals and Clinics, The University of Iowa, Department of Orthopaedics and Rehabilitation, Iowa City, IA (United States); Grosland, Nicole M. [The University of Iowa, Department of Biomedical Engineering, Seamans Center for the Engineering Arts and Sciences, Iowa City, IA (United States); University of Iowa Hospitals and Clinics, The University of Iowa, Department of Orthopaedics and Rehabilitation, Iowa City, IA (United States); The University of Iowa, Center for Computer-Aided Design, Iowa City, IA (United States)

    2008-04-15

    The objective was to develop tools for automating the identification of bony structures, to assess the reliability of this technique against manual raters, and to validate the resulting regions of interest against physical surface scans obtained from the same specimen. Artificial intelligence-based algorithms have been used for image segmentation, specifically artificial neural networks (ANNs). For this study, an ANN was created and trained to identify the phalanges of the human hand. The relative overlap between the ANN and a manual tracer was 0.87, 0.82, and 0.76, for the proximal, middle, and distal index phalanx bones respectively. Compared with the physical surface scans, the ANN-generated surface representations differed on average by 0.35 mm, 0.29 mm, and 0.40 mm for the proximal, middle, and distal phalanges respectively. Furthermore, the ANN proved to segment the structures in less than one-tenth of the time required by a manual rater. The ANN has proven to be a reliable and valid means of segmenting the phalanx bones from CT images. Employing automated methods such as the ANN for segmentation, eliminates the likelihood of rater drift and inter-rater variability. Automated methods also decrease the amount of time and manual effort required to extract the data of interest, thereby making the feasibility of patient-specific modeling a reality. (orig.)

  7. Correction of bony deformities around knee by hemicallotasis using an innovative apparatus

    Directory of Open Access Journals (Sweden)

    Kundu Z

    2005-01-01

    Full Text Available Background: Valgus and varus deformities around the knee are common. Various osteotomies and apparatuses have been described to correct these deformities. Methods: Bony deformities around knee joint in thirty patients (36 joints were corrected by osteotomy in upper tibia or lower femur which was stabilized and distracted with innovatively designed and locally fabricated T-shaped external fixator-cum-distractor. The age of the patients ranged from 5 to 48 years. The causes of deformities were post-traumatic (18, rickets (5, tibia vara (3, idiopathic (3 and Ollier?s disease (1. The deformity was in lower femur in 14 cases and upper tibia in 16 cases. Sixteen patients had genu varum, 13 genu valgum and one patient had post traumatic tackle (wind-sweep deformity i.e. genu varum one side and valgum on the opposite. Results: Good results were achieved in 27 cases (32 joints as deformity was fully corrected with full range of painless post-operative movement (follow up 2-8 yrs. Superficial pin-tract infection was the main but temporary complication particularly in summer and rainy season. Conclusion: The apparatus was found quite useful in stabilizing as well as differentially distracting the osteotomy i.e. hemicallotasis to achieve desirable amount of correction of deformities.

  8. Reversible focal splenial lesions

    International Nuclear Information System (INIS)

    Reversible focal lesions in the splenium of the corpus callosum (SCC) have recently been reported.They are circumscribed and located in the median aspect of the SCC. On MRI, they are hyperintense on T2-W and iso-hypointense on T1-W sequences, with no contrast enhancement. On DWI, SCC lesions are hyperintense with low ADC values, reflecting restricted diffusion due to cytotoxic edema. The common element is the disappearance of imaging abnormalities with time, including normalization of DWI. Clinical improvement is often reported. The most established and frequent causes of reversible focal lesions of the SCC are viral encephalitis, antiepileptic drug toxicity/withdrawal and hypoglycemic encephalopathy. Many other causes have been reported, including traumatic axonal injury. The similar clinical and imaging features suggest a common mechanism induced by different pathological events leading to the same results. Edema and diffusion restriction in focal reversible lesions of the SCC have been attributed to excitotoxic mechanisms that can result from different mechanisms; no unifying relationship has been found to explain all the pathologies associated with SCC lesions. In our opinion, the similar imaging, clinical and prognostic aspects of these lesions depend on a high vulnerability of the SCC to excitotoxic edema and are less dependent on the underlying pathology. In this review, the relevant literature concerning reversible focal lesions in the SCC is analyzed and hypoal lesions in the SCC is analyzed and hypotheses about their pathogenesis are proposed. (orig.)

  9. Tumor and tumor-like lesion of jaw bone: CT findings and clinical applications

    International Nuclear Information System (INIS)

    Objective: To evaluate the CT findings and clinical applications in Jaw bone tumor and tumor-like lesions. Methods: CT appearances of 36 patients with Jaw bone tumor proved by surgery and pathology were reviewed. Results: One osteosarcoma showed irregular soft-tissue mass with osteolytic bone destruction and new tumor bone formation. Six cases of benign tumor or tumor-like lesions showed masses with regular margin, without calcification, new tumor bone formation and periosteal reaction. Six cases of ameloblastoma showed regular margin masses with multilocular and bone expansion. The multiple bone expansion and interspersed bony trabeculae were found in 2 cases of fibrous hyperplasia of bone. Conclusion: Various jaw bone tumor and tumor-like lesions demonstrated different CT features. CT scan was one of important examination methods for diagnosis and extent evaluations. (authors)

  10. Multidirectional tomography and high resolution CT in lesions of the paranasal sinuses and the pharyngeal cavity

    International Nuclear Information System (INIS)

    In 18 cases of neoplasm and 18 of inflammatory lesion of the paranasal sinuses and the pharyngeal cavity the results of high resolution CT (HRCT) were compared with multidirectional tomography. In one third of the cases HRCT gave more information than tomography. The value of HRCT lay in the demonstration of thin bony structures and in the differentiation between decalcification and destruction. Soft tissue involvement of the infratemporal fossa and the pharyngeal cavity is demonstrable at an earlier stage by CT and HRCT than with tomography; the same applies to small lesions in the paranasal sinuses and in the nasal cavity. Lesions in the sphenoid and frontal bones need additional evaluation by a lateral tomography. A.p. tomography becomes necessary if frontal HRCT scans are insufficient. (Auth.)

  11. Enhancement of bony in-growth to metal implants by combining controlled hydroxyapatite coating and heat treatment.

    Science.gov (United States)

    Oron, Amir; Agar, Gauriel; Oron, Uri; Stein, Anat

    2012-07-01

    The rate of bony in-growth to heat-treated and controlled hydroxyapatite metal implants made of either titanium alloy (Ti-6Al-4V) or stainless steel (SS) 316L inserted to the medullar canal of the femur in rats was investigated. It was found that while partial coverage of hydroxyapatite (HA) did not cause a significant elevation of their bonding strength when compared with nonheated implants, HA, and heat treatment caused a significant (p SS implants as well. It is concluded that the novel approach presented in this article, that is, to heat treat implants as well as controlled partial coating of them by HA, prior to their insertion to host bone, produce an enhancement of bone growth to metal implants greater than utilization of each method alone. Our findings may be used to further enhance bony in-growth to metal implants in several clinical settings, producing avid implants with superior integration capabilities. PMID:22447664

  12. Goltz syndrome: a newborn with ectrodactyly and skin lesions.

    Science.gov (United States)

    Sarkar, Shatanik; Patra, Chaitali; Das, Amit; Roy, Sutirtha

    2015-01-01

    Goltz syndrome or Focal Dermal Hypoplasia is a rare multisystem disorder, involving all the three germ cell layers. The disease is thought to be inherited in X-linked dominant fashion with heterogeneous mutations of the PORCN gene at Xp11.23 locus. Majority of the cases are sporadic, mainly due to postzygotic somatic mutations. The clinical spectrum includes characteristic cutaneous manifestations, multiple skeletal anomalies, and involvement of the eyes, hair, nails, kidneys, and so on. Considerable variability is noted in the clinical expression of the disease probably due to genomic mosaicism. Around 300 cases of Goltz syndrome have been reported in the literature. Here, we report such a case with characteristic skin lesions, multiple bony defects, distinctive facial features, coloboma of iris, and bilateral hydronephrosis. The diagnosis was evident immediately after birth due to the characteristic clinical picture of the baby. PMID:25814752

  13. Concerning the etiology of bony bridges along the sides of the terminal phalanx of the great toe

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, E.

    1987-06-01

    Besides in acromegaly bony bridges at the terminal phalanx of the great toe occur in one third of cases with peripheral signs of diffuse idiopathic skeletal hyperostosis, systemic diseases as rheumatoid arthritis or psoriatic arthritis with chronic inflammation of the interphalangeal joint of the great toe respectively extraarticular osseous changes in the terminal phalanx of the great toe do not influence the development of such bridges.

  14. Is immediate bony microsurgical reconstruction after head and neck tumor ablation associated with a higher rate of local recurrence?

    Science.gov (United States)

    Hanken, Henning; Wilkens, Ralf; Riecke, Björn; Al-Dam, Ahmed; Tribius, Silke; Kluwe, Lan; Smeets, Ralf; Heiland, Max; Eichhorn, Wolfgang; Gröbe, Alexander

    2015-04-01

    The purpose of this retrospective study was to examine the possible effect of immediate bony microvascular free flap reconstruction of mandibular defects after radical tumor resection of oral squamous cell carcinoma (OSCC) on the rate of local relapse. Our own data regarding recurrence rates for 1-step immediate reconstruction were compared to the published recurrence rates of 2-step reconstructions. A total of 21 patients (aged 45-77 years) with OSCC who underwent a primary surgical therapy with subsequent immediate bony microvascular free flap reconstruction of mandibular defects were followed up for 18-38 months. Four local relapses (19%) were recorded, all in patients with initial tumor stage of T4. Although intraoperative histological findings were R0 in all 21 cases, definitive histology later detected R1 status in the resected bone in 2 cases (10%). Immediate bony free flap reconstruction of mandibular defects after radical surgical resection of OSCC does not seem to increase the risk of local recurrence nor affect patient survival when compared with the 2-step surgical approach. PMID:25701393

  15. Reversible focal splenial lesions

    Energy Technology Data Exchange (ETDEWEB)

    Gallucci, Massimo; Limbucci, Nicola [University of L' Aquila, Department of Radiology, S. Salvatore Hospital, L' Aquila (Italy); Paonessa, Amalia [Loreto Nuovo Hospital, Department of Neuroradiology, Napoli (Italy); Caranci, Ferdinando [Federico II University, Department of Neurological Sciences, Napoli (Italy)

    2007-07-15

    Reversible focal lesions in the splenium of the corpus callosum (SCC) have recently been reported.They are circumscribed and located in the median aspect of the SCC. On MRI, they are hyperintense on T2-W and iso-hypointense on T1-W sequences, with no contrast enhancement. On DWI, SCC lesions are hyperintense with low ADC values, reflecting restricted diffusion due to cytotoxic edema. The common element is the disappearance of imaging abnormalities with time, including normalization of DWI. Clinical improvement is often reported. The most established and frequent causes of reversible focal lesions of the SCC are viral encephalitis, antiepileptic drug toxicity/withdrawal and hypoglycemic encephalopathy. Many other causes have been reported, including traumatic axonal injury. The similar clinical and imaging features suggest a common mechanism induced by different pathological events leading to the same results. Edema and diffusion restriction in focal reversible lesions of the SCC have been attributed to excitotoxic mechanisms that can result from different mechanisms; no unifying relationship has been found to explain all the pathologies associated with SCC lesions. In our opinion, the similar imaging, clinical and prognostic aspects of these lesions depend on a high vulnerability of the SCC to excitotoxic edema and are less dependent on the underlying pathology. In this review, the relevant literature concerning reversible focal lesions in the SCC is analyzed and hypotheses about their pathogenesis are proposed. (orig.)

  16. Linhas escleróticas metafisárias em crianças e adolescentes em uso de alendronato / Sclerotic metaphyseal lines in children and adolescents treated with alendronate

    Scientific Electronic Library Online (English)

    Érika C.C., Silva; Maria Teresa R.A., Terreri; Tania C.M. de, Castro; Cássia P.L., Barbosa; Artur R.C., Fernandes; Maria Odete E., Hilário.

    2010-06-01

    Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese INTRODUÇÃO: Os bisfosfonatos inibem a reabsorção óssea pela interferência na ação dos osteoclastos. Dentre os efeitos adversos, as linhas escleróticas em metáfise de ossos longos são descritas como principal alteração radiográfica na faixa etária pediátrica. OBJETIVO: Avaliar a frequência de alteraç [...] ões radiográficas causadas pelo alendronato utilizado em crianças e adolescentes com baixa densidade óssea ou calcinose. PACIENTES E MÉTODOS: Foi realizado um estudo do tipo coorte retrospectiva analisando-se prontuários de 21 pacientes que fizeram uso de alendronato semanal por no mínimo 10 meses. Os pacientes realizaram radiografias de ossos longos antes do início do alendronato e aproximadamente um ano após o seu uso. RESULTADOS: Onze pacientes (52,3%) apresentaram linhas escleróticas em metáfise dos ossos longos. A localização mais frequente foi em tíbia (8/11 pacientes), seguida de fêmur (7/11), úmero (6/11), rádio (4/11), ulna (3/11) e fíbula (2/11). Nenhum paciente apresentou regressão das alterações radiográficas durante o tempo de evolução (até 1,1 ano após a suspensão do alendronato). CONCLUSÃO: Se usado com critério, o alendronato é seguro e as alterações radiográficas não mostraram ter um significado mais importante. Abstract in english INTRODUCTION: Bisphosphonates inhibit bone resorption by interfering with the action of osteoclasts. Among the adverse effects, sclerotic lines observed in the metaphysis of long bones have been described as the main imaging finding in pediatric patients. OBJECTIVE: To evaluate the frequency of radi [...] ographic changes caused by alendronate in children and adolescents with low bone density or calcinosis. PATIENTS AND METHODS: We conducted a cross-sectional study with 21 patients who were treated with once-weekly alendronate for at least 10 months. Patients underwent x-rays of long bones before the start of alendronate and approximately one year after its use. RESULTS: Eleven patients (52.3%) had sclerotic lines in the metaphysis of long bones. The most frequent site was the tibia (8/11 patients), followed by the femur (7/11), humerus (6/11), radius (4/11), ulna (3/11), and fibula (2/11). Regression of radiographic changes during the study period (up to 1.1 years after discontinuation of alendronate) was not observed. CONCLUSION: If used carefully, alendronate is safe and radiographic changes have not been shown to be clinically relevant.

  17. Osteoporosis posmenopausia según densitometría ósea Postmenopausal osteoporosis according to bony densitometry

    Directory of Open Access Journals (Sweden)

    Dayana Couto Núñez

    2011-12-01

    Full Text Available Se realizó un estudio descriptivo y transversal de 146 mujeres, atendidas en la Consulta de Climaterio del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, durante el 2010, con vistas a medir la pérdida de masa ósea en ellas. Los resultados mostraron como factores de riesgo predominantes: la ooforectomía bilateral antes de los 50 años, el cese de la menstruación antes de los 40 años y el bajo peso. La densitometría reveló que 45,9 % de las féminas padecía osteopenia y 35,6 %, osteoporosis, con alta significación de la relación entre el climaterio y los resultados densitométricos. Se concluyó que la osteoporosis es frecuente en esta etapa, por lo que debe ser diagnosticada precozmente, de modo que se asegure una terapia eficaz y mejore la calidad de vida.A descriptive and cross-sectional study in 146 women, assisted at the Climacteric Department in "Dr. Juan Bruno Zayas Alfonso" Teaching General Hospital from Santiago de Cuba was carried out during the 2010, with the objective of measuring the loss of bony mass in them. The results showed as predominant risk factors: the bilateral oophorectomy before 50 years, the ceasing of menstruation before 40 years and low weight. The densitometry revealed that 45,9 % of the females suffered from osteopenia and 35,6 %, osteoporosis, with high significance of the relation between the climacteric and the densitometric results. It was concluded that osteoporosis is frequent in this stage, so that it should be early diagnosed, and an effective therapy be assured to improve life quality.

  18. Osteoporosis posmenopausia según densitometría ósea / Postmenopausal osteoporosis according to bony densitometry

    Scientific Electronic Library Online (English)

    Dayana, Couto Núñez; Danilo, Nápoles Méndez; Isabel, Deulofeu Betancourt.

    1765-17-01

    Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se realizó un estudio descriptivo y transversal de 146 mujeres, atendidas en la Consulta de Climaterio del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, durante el 2010, con vistas a medir la pérdida de masa ósea en ellas. Los resultados mostraron como factores de ries [...] go predominantes: la ooforectomía bilateral antes de los 50 años, el cese de la menstruación antes de los 40 años y el bajo peso. La densitometría reveló que 45,9 % de las féminas padecía osteopenia y 35,6 %, osteoporosis, con alta significación de la relación entre el climaterio y los resultados densitométricos. Se concluyó que la osteoporosis es frecuente en esta etapa, por lo que debe ser diagnosticada precozmente, de modo que se asegure una terapia eficaz y mejore la calidad de vida. Abstract in english A descriptive and cross-sectional study in 146 women, assisted at the Climacteric Department in "Dr. Juan Bruno Zayas Alfonso" Teaching General Hospital from Santiago de Cuba was carried out during the 2010, with the objective of measuring the loss of bony mass in them. The results showed as predomi [...] nant risk factors: the bilateral oophorectomy before 50 years, the ceasing of menstruation before 40 years and low weight. The densitometry revealed that 45,9 % of the females suffered from osteopenia and 35,6 %, osteoporosis, with high significance of the relation between the climacteric and the densitometric results. It was concluded that osteoporosis is frequent in this stage, so that it should be early diagnosed, and an effective therapy be assured to improve life quality.

  19. MRI of degenerative bone marrow lesions in experimental osteoarthritis of canine knee joints

    International Nuclear Information System (INIS)

    Objective. The objective of this study was to determine the value of MRI in the detection of degenerative bone marrow abnormalities in an animal osteoarthritis model. Design. In 10 dogs with experimentally induced unilateral osteoarthritis of the knee, MRI was performed using two-dimensional spin-echo (2D-SE) and three-dimensional gradient-echo (3D-GE) imaging. Contrast enhanced T1-weighted 2D-SE sequences were also obtained after injection of gadolinium-DTPA. The results were compared with the gross and histopathologic findings and with radiography. Results. Histopathologic specimens revealed 21 osteosclerotic lesions and 5 intraosseous cysts. On 2D-SE images, 24 of 26 lesions were detected, while 21 of 26 lesions were identified on 2D-GE sequences. Radiography, including conventional tomography, demonstrated 9 of 26 lesions. Regardless of the sequence weighting, all osteosclerotic lesions appeared hypointense on MRI. Signal loss in bone sclerosis resulted primarily from the reduction of intact fat marrow, the increased bone density being of secondary importance. Quantitative signal analysis allowed approximate estimation of the grade of sclerosis. On postcontrast images, sclerotic bone remained hypointense, although significant but non-specific enhancement relative to the normal fat marrow was observed. The extent of contrast enhancement did not correlate with the grade of osteosclerosis. All five cysts were readily diagnosed by MRI. Cysts displayed either central od by MRI. Cysts displayed either central or marginal contrast enhancement within their cavities. Conclusions. MRI provides a sensitive method for the diagnosis of osteoarthritic bone abnormalities, allowing their differentiation from most non-degenerative subarticular lesions. (orig.). With 1 tab

  20. Hypervascular liver lesions.

    Science.gov (United States)

    Kamaya, Aya; Maturen, Katherine E; Tye, Grace A; Liu, Yueyi I; Parti, Naveen N; Desser, Terry S

    2009-10-01

    Hypervascular hepatocellular lesions include both benign and malignant etiologies. In the benign category, focal nodular hyperplasia and adenoma are typically hypervascular. In addition, some regenerative nodules in cirrhosis may be hypervascular. Malignant hypervascular primary hepatocellular lesions include hepatocellular carcinoma, fibrolamellar carcinoma, and peripheral cholangiocarcinoma. Vascular liver lesions often appear hypervascular because they tend to follow the enhancement of the blood pool; these include hemangiomas, arteriovenous malformations, angiosarcomas, and peliosis. While most gastrointestinal malignancies that metastasize to the liver will appear hypovascular on arterial and portal-venous phase imaging, certain cancers such as metastatic neuroendocrine tumors (including pancreatic neuroendocrine tumors, carcinoid, and gastrointestinal stromal tumors) tend to produce hypervascular metastases due to the greater recruitment of arterial blood supply. Finally, rare hepatic lesions such as glomus tumor and inflammatory pseudotumor may have a hypervascular appearance. PMID:19842564

  1. Uterine vascular lesions.

    Science.gov (United States)

    Vijayakumar, Abhishek; Srinivas, Amruthashree; Chandrashekar, Babitha Moogali; Vijayakumar, Avinash

    2013-01-01

    Vascular lesions of the uterus are rare; most reported in the literature are arteriovenous malformations (AVMs). Uterine AVMs can be congenital or acquired. In recent years, there has been an increasing number of reports of acquired vascular lesions of the uterus following pregnancy, abortion, cesarean delivery, and curettage. It can be seen from these reports that there is confusion concerning the terminology of uterine vascular lesions. There is also a lack of diagnostic criteria and management guidelines, which has led to an increased number of unnecessary invasive procedures (eg, angiography, uterine artery embolization, hysterectomy for abnormal vaginal bleeding). This article familiarizes readers with various vascular lesions of the uterus and their management. PMID:24340126

  2. Skin lesion KOH exam

    Science.gov (United States)

    The skin lesion KOH exam is a test to diagnose a fungal infection of the skin . ... placed in liquid containing the chemical potassium hydroxide (KOH). The liquid is examined under the microscope. KOH ...

  3. Uterine Vascular Lesions

    Science.gov (United States)

    Vijayakumar, Abhishek; Srinivas, Amruthashree; Chandrashekar, Babitha Moogali; Vijayakumar, Avinash

    2013-01-01

    Vascular lesions of the uterus are rare; most reported in the literature are arteriovenous malformations (AVMs). Uterine AVMs can be congenital or acquired. In recent years, there has been an increasing number of reports of acquired vascular lesions of the uterus following pregnancy, abortion, cesarean delivery, and curettage. It can be seen from these reports that there is confusion concerning the terminology of uterine vascular lesions. There is also a lack of diagnostic criteria and management guidelines, which has led to an increased number of unnecessary invasive procedures (eg, angiography, uterine artery embolization, hysterectomy for abnormal vaginal bleeding). This article familiarizes readers with various vascular lesions of the uterus and their management. PMID:24340126

  4. Skin lesion of blastomycosis

    Science.gov (United States)

    ... central and southeastern United States, and in Canada, India, Israel, Saudi Arabia, and Africa. A person gets ... is diagnosed by identifying the fungus in a culture taken from a skin lesion. This usually requires ...

  5. Pigmented Lesions in Children

    OpenAIRE

    Russak, Julie E.; Dinulos, James G. H.

    2006-01-01

    Pigmented lesions in childhood can pose significant diagnostic and therapeutic challenges. This article examines the most common pigmented lesions encountered in childhood. Special emphasis is placed on the diagnosis and management of congenital melanocytic nevi, acquired melanocytic nevi, clonal nevi, halo nevi, atypical melanocytic nevi, Spitz nevi, recurrent nevi, childhood melanoma, blue nevi, speckled lentiginous nevi, and other melanocytic nevi such as nevus of Ota and nevus of Ito. Pro...

  6. Scales and Dermal Skeletal Histology of an Early Bony Fish Psarolepis romeri and Their Bearing on the Evolution of Rhombic Scales and Hard Tissues

    OpenAIRE

    Qu, Qingming; Zhu, Min; Wang, Wei

    2013-01-01

    Recent discoveries of early bony fishes from the Silurian and earliest Devonian of South China (e. g. Psarolepis, Achoania, Meemannia, Styloichthys and Guiyu) have been crucial in understanding the origin and early diversification of the osteichthyans (bony fishes and tetrapods). All these early fishes, except Guiyu, have their dermal skeletal surface punctured by relatively large pore openings. However, among these early fishes little is known about scale morphology and dermal skeletal histo...

  7. Detection of hypoplasia of bony cochlear nerve canal by virtual endoscopy: a pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Quan Yong; Wu Lebin; Gong Wuxian; Gong Ruozhen (Shandong Medical Imaging Research Institute, Shandong Univeristy, Jinan, Shandong (China)), email: grzh99@yahoo.com.cn; Zu Zushan (Dept. of Radiology, Wendeng Central Hospital, Weifang Medical College, Weihai (China))

    2011-09-15

    Background: Dimensions of the bony cochlear nerve canal (BCNC) have been proposed as a potential diagnostic standard for hypoplasia of BCNC, but the standard remains inconsistent. We have previously found that a helix-like shape appears in normal BCNCs at VE images, whereas, the sign does not appear in some hypoplastic BCNCs. Purpose: To retrospectively examine the feasibility of computed tomographic (CT) virtual endoscopy (VE) in the evaluation of hypoplasia of BCNC on the basis of absence of a helix-like shape. Material and Methods: Twenty ears in 14 consecutive patients (mean age 5.5 years, range 1-15 years, 6 boys, 8 girls) diagnosed with hypoplasia of BCNC were included in this work. One hundred ears in 50 gender- and age-matched individuals (mean age 6.6 years, range 1-15 years, 29 boys, 21 girls) without inner ear disease and internal auditory canal (IAC) malformations served as controls. The presence or absence of a helix-like shape was evaluated by two independent reviewers. The value of VE for the diagnosis of hypoplasia of BCNC was assessed with clinical results and routine radiologic evaluation as the reference standard. Inter-observer agreement was calculated. Sensitivity, specificity, and accuracy were selected to test the diagnostic ability of the VE. Results: Absence of a helix-like shape was found in the cochlear area of 17 of 20 ears in patients with hypoplasia of BCNC but in none of the control subjects. Inter-observer agreement was substantial (? = 0.773). The diagnostic rates of absence of a helix-like shape for hypoplasia of BCNC in terms of sensitivity, specificity, and accuracy were 85%, 100%, and 98%, respectively. There were significant differences between the two groups with respect to VE findings for absence of a helix-like shape (P < 0.001). Conclusion: The absence of a helix-like shape at VE images may be used as a potentially useful sign in the diagnosis of hypoplasia of BCNC

  8. Permian-Triassic Osteichthyes (bony fishes): diversity dynamics and body size evolution.

    Science.gov (United States)

    Romano, Carlo; Koot, Martha B; Kogan, Ilja; Brayard, Arnaud; Minikh, Alla V; Brinkmann, Winand; Bucher, Hugo; Kriwet, Jürgen

    2014-11-27

    The Permian and Triassic were key time intervals in the history of life on Earth. Both periods are marked by a series of biotic crises including the most catastrophic of such events, the end-Permian mass extinction, which eventually led to a major turnover from typical Palaeozoic faunas and floras to those that are emblematic for the Mesozoic and Cenozoic. Here we review patterns in Permian-Triassic bony fishes, a group whose evolutionary dynamics are understudied. Based on data from primary literature, we analyse changes in their taxonomic diversity and body size (as a proxy for trophic position) and explore their response to Permian-Triassic events. Diversity and body size are investigated separately for different groups of Osteichthyes (Dipnoi, Actinistia, 'Palaeopterygii', 'Subholostei', Holostei, Teleosteomorpha), within the marine and freshwater realms and on a global scale (total diversity) as well as across palaeolatitudinal belts. Diversity is also measured for different palaeogeographical provinces. Our results suggest a general trend from low osteichthyan diversity in the Permian to higher levels in the Triassic. Diversity dynamics in the Permian are marked by a decline in freshwater taxa during the Cisuralian. An extinction event during the end-Guadalupian crisis is not evident from our data, but 'palaeopterygians' experienced a significant body size increase across the Guadalupian-Lopingian boundary and these fishes upheld their position as large, top predators from the Late Permian to the Late Triassic. Elevated turnover rates are documented at the Permian-Triassic boundary, and two distinct diversification events are noted in the wake of this biotic crisis, a first one during the Early Triassic (dipnoans, actinistians, 'palaeopterygians', 'subholosteans') and a second one during the Middle Triassic ('subholosteans', neopterygians). The origination of new, small taxa predominantly among these groups during the Middle Triassic event caused a significant reduction in osteichthyan body size. Neopterygii, the clade that encompasses the vast majority of extant fishes, underwent another diversification phase in the Late Triassic. The Triassic radiation of Osteichthyes, predominantly of Actinopterygii, which only occurred after severe extinctions among Chondrichthyes during the Middle-Late Permian, resulted in a profound change within global fish communities, from chondrichthyan-rich faunas of the Permo-Carboniferous to typical Mesozoic and Cenozoic associations dominated by actinopterygians. This turnover was not sudden but followed a stepwise pattern, with leaps during extinction events. PMID:25431138

  9. Detection of hypoplasia of bony cochlear nerve canal by virtual endoscopy: a pilot study

    International Nuclear Information System (INIS)

    Background: Dimensions of the bony cochlear nerve canal (BCNC) have been proposed as a potential diagnostic standard for hypoplasia of BCNC, but the standard remains inconsistent. We have previously found that a helix-like shape appears in normal BCNCs at VE images, whereas, the sign does not appear in some hypoplastic BCNCs. Purpose: To retrospectively examine the feasibility of computed tomographic (CT) virtual endoscopy (VE) in the evaluation of hypoplasia of BCNC on the basis of absence of a helix-like shape. Material and Methods: Twenty ears in 14 consecutive patients (mean age 5.5 years, range 1-15 years, 6 boys, 8 girls) diagnosed with hypoplasia of BCNC were included in this work. One hundred ears in 50 gender- and age-matched individuals (mean age 6.6 years, range 1-15 years, 29 boys, 21 girls) without inner ear disease and internal auditory canal (IAC) malformations served as controls. The presence or absence of a helix-like shape was evaluated by two independent reviewers. The value of VE for the diagnosis of hypoplasia of BCNC was assessed with clinical results and routine radiologic evaluation as the reference standard. Inter-observer agreement was calculated. Sensitivity, specificity, and accuracy were selected to test the diagnostic ability of the VE. Results: Absence of a helix-like shape was found in the cochlear area of 17 of 20 ears in patients with hypoplasia of BCNC but in none of the control subjects. Inter-observer agreement was substantial (? =er-observer agreement was substantial (? = 0.773). The diagnostic rates of absence of a helix-like shape for hypoplasia of BCNC in terms of sensitivity, specificity, and accuracy were 85%, 100%, and 98%, respectively. There were significant differences between the two groups with respect to VE findings for absence of a helix-like shape (P < 0.001). Conclusion: The absence of a helix-like shape at VE images may be used as a potentially useful sign in the diagnosis of hypoplasia of BCNC

  10. Cystic renal lesions

    International Nuclear Information System (INIS)

    Cystic renal lesions are most often simple or complicated cysts, which can be seen solitary or as part of cystic renal disease. The minority of these lesions are benign or malignant cystic tumors. The classification of cystic renal masses by Bosniak (category I-IV) based on specific ultrasound and CT features is very useful for the characterization of the lesion and for the therapeutic decision. The main objective of this classification is to differentiate nonsurgical (category II) from surgical cystic masses (category III/IV). Ultrasound is the first modality of choice in the diagnostic work-up of cystic renal masses, because an accurate and economically reasonable diagnosis of the frequent simple cyst can be made by maintaining rigid ultrasound criteria of the Bosniak classification. If a complicated cyst or a cystic tumor is suspected a threephasic contrast-enhanced CT of the kidneys should be performed. MRI is superior to CT in the characterization of complex cystic masses. (orig.)

  11. Intraosseous hemangioma as a rare differential diagnosis of intranasal bony tumor.

    Science.gov (United States)

    Kim, Jeong Hong; Park, Heae Surng; Kang, Ju Wan

    2013-07-01

    Intraosseous hemangioma is a benign vascular tumor of the bone. The most common site of this tumor is the vertebral body, followed by calvarial bones. Intraosseous hemangioma of the nasal cavity is extremely rare. This lesion had en bloc been resected through the endoscopic approach without preoperative embolization, significant intraoperative bleeding, and postoperative events. We report a rare case of intraosseous hemangioma of the nasal cavity with distinctive radiologic findings. Clinicians should be well familiar with the radiologic findings and clinical features of this tumor, which would be helpful in making a correct diagnosis and management plan. PMID:23851855

  12. Distance-to-Agreement Investigation of Tomotherapy's Bony Anatomy-Based Autoregistration and Planning Target Volume Contour-Based Optimization

    International Nuclear Information System (INIS)

    Purpose: To compare Tomotherapy's megavoltage computed tomography bony anatomy autoregistration with the best achievable registration, assuming no deformation and perfect knowledge of planning target volume (PTV) location. Methods and Materials: Distance-to-agreement (DTA) of the PTV was determined by applying a rigid-body shift to the PTV region of interest of the prostate from its reference position, assuming no deformations. Planning target volume region of interest of the prostate was extracted from the patient archives. The reference position was set by the 6 degrees of freedom (dof)—x, y, z, roll, pitch, and yaw—optimization results from the previous study at this institution. The DTA and the compensating parameters were calculated by the shift of the PTV from the reference 6-dof to the 4-dof—x, y, z, and roll—optimization. In this study, the effectiveness of Tomotherapy's 4-dof bony anatomy–based autoregistration was compared with the idealized 4-dof PTV contour-based optimization. Results: The maximum DTA (maxDTA) of the bony anatomy-based autoregistration was 3.2 ± 1.9 mm, with the maximum value of 8.0 mm. The maxDTA of the contour-based optimization was 1.8 ± 1.3 mm, with the maximum value of 5.7 mm. Comparison of Pearson correlation of the compensating parameters between the 2 4-dof optimization algorithms shows that there is a small but statistically significant correlation in y and z (0.236 and 0.300, respectively), whereas there is very weak correlation in x and roll (0.062 and 0.025, respectively). Conclusions: We find that there is an average improvement of approximately 1 mm in terms of maxDTA on the PTV going from 4-dof bony anatomy-based autoregistration to the 4-dof contour-based optimization. Pearson correlation analysis of the 2 4-dof optimizations suggests that uncertainties due to deformation and inadequate resolution account for much of the compensating parameters, but pitch variation also makes a statistically significant contribution

  13. A new species of Hyphessobrycon (Teleostei: Characidae) from the upper rio Tocantins drainage, with bony hooks on fins

    OpenAIRE

    Bertaco, Vinicius A.; Malabarba, Luiz R.

    2005-01-01

    A new species of characid, Hyphessobrycon hamatus, is described from the upper rio Tocantins, Goiás, Brazil. The new species is distinguished from all other Hyphessobrycon species by the presence of bony hooks on dorsal, anal, pelvic, and pectoral fins of males, the two black humeral spots, the 4 or 5 teeth in the inner series of the premaxilla, a maxilla with 2-3 teeth, the iii-v, 16-18 anal-fin rays, and a lateral line with 10-32 perforated scales and 33-35 scales in a longitudinal series....

  14. SU-E-J-94: Positioning Errors Resulting From Using Bony Anatomy Alignment for Treating SBRT Lung Tumor

    International Nuclear Information System (INIS)

    Purpose: To quantify patient setups errors based on bony anatomy registration rather than 3D tumor alignment for SBRT lung treatments. Method: A retrospective study was performed for patients treated with lung SBRT and imaged with kV cone beam computed tomography (kV-CBCT) image-guidance. Daily CBCT images were registered to treatment planning CTs based on bony anatomy alignment and then inter-fraction tumor movement was evaluated by comparing shift in the tumor center in the medial-lateral, anterior-posterior, and superior-inferior directions. The PTV V100% was evaluated for each patient based on the average daily tumor displacement to assess the impact of the positioning error on the target coverage when the registrations were based on bony anatomy. Of the 35 patients studied, 15 were free-breathing treatments, 10 used abdominal compression with a stereotactic body frame, and the remaining 10 were performed with BodyFIX vacuum bags. Results: For free-breathing treatments, the range of tumor displacement error is between 1–6 mm in the medial-lateral, 1–13 mm in the anterior-posterior, and 1–7 mm in the superior-inferior directions. These positioning errors lead to 6–22% underdose coverage for PTV - V100% . Patients treated with abdominal compression immobilization showed positional errors of 0–4mm mediallaterally, 0–3mm anterior-posteriorly, and 0–2 mm inferior-superiorly with PTV - V100% underdose ranging between 6–17%. For patients immobilized with the vacuum bags, the positional errors were found to be 0–1 mm medial-laterally, 0–1mm anterior-posteriorly, and 0–2 mm inferior-superiorly with PTV - V100% under dose ranging between 5–6% only. Conclusion: It is necessary to align the tumor target by using 3D image guidance to ensure adequate tumor coverage before performing SBRT lung treatments. The BodyFIX vacuum bag immobilization method has the least positioning errors among the three methods studied when bony anatomy is used for registration

  15. Bilateral globus pallidus lesions.

    Science.gov (United States)

    Alquist, Caroline Raasch; McGoey, Robin; Bastian, Frank; Newman, William

    2012-01-01

    Following a hypoxic-ischemic insult, the globus pallidus is selectively spared from ischemic injury in contrast to the caudate and putamen. The known causes for hemorrhagic and necrotic lesions selective for injuring the globus pallidus are varied but few. The most widely known etiology is in fatal cases of carbon monoxide poisoning. Additionally reported associations include fatalities involving 3,4-methylenedioxymethamphetamine; cocaine; opiates; and cyanide poisoning. These bilateral globus palladus necrotic lesions have been reported to occur in 5-10% of opiate addicts. In this article, we present a striking photo of selective symmetrical bilateral globus pallidus necrosis following cocaine and opiate abuse. PMID:22866355

  16. Reappearing CT lesions : 4 cases.

    Directory of Open Access Journals (Sweden)

    Singh G

    1999-01-01

    Full Text Available An overwhelming majority of disappearing CT lesions in India have been aetiologically linked to cysticercosis. We report 4 patients with disappearing CT lesions in whom the lesion later reappeared at the same (3 patients or different site (1 patient. One patient was a Taenia carrier. Serial MRI evaluation in one patient revealed a persisting lesion in the interval period. The contribution of these observations towards the understanding of the aetiology of disappearing CT lesions is discussed.

  17. MRI of orbital lesions

    International Nuclear Information System (INIS)

    MR imaging is helpful for evaluation of the extent of the orbital lesion. Myositic pseudotumor and lymphoid hyperplasia tend to have intermediate signal intensity on T2-weighted images, may be of value in the differential diagnosis of myositic pseudotumor. (author)

  18. Immunopathology of skin lesions

    Directory of Open Access Journals (Sweden)

    Khan Nazoora

    2001-09-01

    Full Text Available A study was conducted on 130 patients suffering from skin lesions which included psoriasis, lichen planus, DLE, pemphigus, vitiligo and alopecia areata. Forty age-and-sex-matched healthy individuals served as control. Serum IgG, IgM, and circulating immune complexes (CIC were estimated. Significant increase in serum IgG (1937.2 ± 1030.43 mg% and IgM (232.12 ± 136.98 mg% was observed in all the skin lesions when compared with controls except in lichen planus where they were significantly lowered, values being 580.61± 77.35 mg% and 66.88 ± 6.59mg% respectively. CIC levels were significantly raised (P<0.00 1 in various skin lesions (40.49±23.29 when compared with controls (17.68± 3.21, but no significance was observed in lichen planus( 17.72 ± 4.28. Serum IgG, IgM and CIC were statistically significantly altered depending on the extent of the lesion and lowered significantly to almost normal values following treatment, thereby confirming the role of immunity in the pathogenesis of these skin disorders.

  19. Genital lesions following bestiality

    Directory of Open Access Journals (Sweden)

    Mittal A

    2000-01-01

    Full Text Available A 48-year-old man presented with painful genital lesions with history of bestiality and abnor-mal sexual behaviour. Examination revealed multiple irregular tender ulcers and erosions, with phimosis and left sided tender inguinal adenopathy. VDRL, TPHA, HIV-ELISA were negative. He was treated with ciprofloxacin 500mg b.d. along with saline compresses with complete resolution.

  20. Genital lesions following bestiality

    OpenAIRE

    Mittal A; Shenoi Shrutakirthi; Kumar K.; Ps, Sharma

    2000-01-01

    A 48-year-old man presented with painful genital lesions with history of bestiality and abnor-mal sexual behaviour. Examination revealed multiple irregular tender ulcers and erosions, with phimosis and left sided tender inguinal adenopathy. VDRL, TPHA, HIV-ELISA were negative. He was treated with ciprofloxacin 500mg b.d. along with saline compresses with complete resolution.

  1. Post-traumatic glenohumeral cartilage lesions: a systematic review

    Directory of Open Access Journals (Sweden)

    Stussi Edgar

    2008-07-01

    Full Text Available Abstract Background Any cartilage damage to the glenohumeral joint should be avoided, as these damages may result in osteoarthritis of the shoulder. To understand the pathomechanism leading to shoulder cartilage damage, we conducted a systematic review on the subject of articular cartilage lesions caused by traumas where non impression fracture of the subchondral bone is present. Methods PubMed (MEDLINE, ScienceDirect (EMBASE, BIOBASE, BIOSIS Previews and the COCHRANE database of systematic reviews were systematically scanned using a defined search strategy to identify relevant articles in this field of research. First selection was done based on abstracts according to specific criteria, where the methodological quality in selected full text articles was assessed by two reviewers. Agreement between raters was investigated using percentage agreement and Cohen's Kappa statistic. The traumatic events were divided into two categories: 1 acute trauma which refers to any single impact situation which directly damages the articular cartilage, and 2 chronic trauma which means cartilage lesions due to overuse or disuse of the shoulder joint. Results The agreement on data quality between the two reviewers was 93% with a Kappa value of 0.79 indicating an agreement considered to be 'substantial'. It was found that acute trauma on the shoulder causes humeral articular cartilage to disrupt from the underlying bone. The pathomechanism is said to be due to compression or shearing, which can be caused by a sudden subluxation or dislocation. However, such impact lesions are rarely reported. In the case of chronic trauma glenohumeral cartilage degeneration is a result of overuse and is associated to other shoulder joint pathologies. In these latter cases it is the rotator cuff which is injured first. This can result in instability and consequent impingement which may progress to glenohumeral cartilage damage. Conclusion The great majority of glenohumeral cartilage lesions without any bony lesions are the results of overuse. Glenohumeral cartilage lesions with an intact subchondral bone and caused by an acute trauma are either rare or overlooked. And at increased risk for such cartilage lesions are active sportsmen with high shoulder demand or athletes prone to shoulder injury.

  2. Bony outgrowths on the jaws of an extinct sperm whale support macroraptorial feeding in several stem physeteroids

    Science.gov (United States)

    Lambert, Olivier; Bianucci, Giovanni; Beatty, Brian L.

    2014-06-01

    Several extinct sperm whales (stem Physeteroidea) were recently proposed to differ markedly in their feeding ecology from the suction-feeding modern sperm whales Kogia and Physeter. Based on cranial, mandibular, and dental morphology, these Miocene forms were tentatively identified as macroraptorial feeders, able to consume proportionally large prey using their massive teeth and robust jaws. However, until now, no corroborating evidence for the use of teeth during predation was available. We report on a new specimen of the stem physeteroid Acrophyseter, from the late middle to early late Miocene of Peru, displaying unusual bony outgrowths along some of the upper alveoli. Considering their position and outer shape, these are identified as buccal maxillary exostoses. More developed along posterior teeth and in tight contact with the high portion of the dental root outside the bony alveoli, the exostoses are hypothesized to have developed during powerful bites; they may have worked as buttresses, strengthening the teeth when facing intense occlusal forces. These buccal exostoses further support a raptorial feeding technique for Acrophyseter and, indirectly, for other extinct sperm whales with a similar oral apparatus ( Brygmophyseter, Livyatan, Zygophyseter). With a wide size range, these Miocene stem physeteroids were major marine macropredators, occupying ecological niches nowadays mostly taken by killer whales.

  3. Molecular, cellular and histological changes in skin from a larval to an adult phenotype during bony fish metamorphosis.

    Science.gov (United States)

    Campinho, Marco A; Silva, Nádia; Sweeney, Glen E; Power, Deborah M

    2007-02-01

    Developmental models for skin exist in terrestrial and amphibious vertebrates but there is a lack of information in aquatic vertebrates. We have analysed skin epidermal development of a bony fish (teleost), the most successful group of extant vertebrates. A specific epidermal type I keratin cDNA (hhKer1), which may be a bony-fish-specific adaptation associated with the divergence of skin development (scale formation) compared with other vertebrates, has been cloned and characterized. The expression of hhKer1 and collagen 1alpha1 in skin taken together with the presence or absence of keratin bundle-like structures have made it possible to distinguish between larval and adult epidermal cells during skin development. The use of a flatfish with a well-defined larval to juvenile transition as a model of skin development has revealed that epidermal larval basal cells differentiate directly to epidermal adult basal cells at the climax of metamorphosis. Moreover, hhKer1 expression is downregulated at the climax of metamorphosis and is inversely correlated with increasing thyroxin levels. We suggest that, whereas early mechanisms of skin development between aquatic and terrestrial vertebrates are conserved, later mechanisms diverge. PMID:17028894

  4. Oblique coronal MRI in the evaluation of bony stenosis of the cervical foramina: objectiveness and correlation with radiograph

    International Nuclear Information System (INIS)

    To determine the utility of oblique coronal MR (OMR) imaging in the evaluation of bony foraminal narrowing of the cervical spine by comparison of its findings with those of combined axial and sagittal MR (CMR) imaging and correlation with the findings of oblique radiography. One hundred and eight cervical neural foramina in 18 patients formed the basis of this study. Three radiologists working in a blind fashion independently graded the degree of bony narrowing of the foramina seen on OMR and CMR images and on oblique radiographs (0=none, 1=stenosis below 25% of AP dimension, 2=stenosis exceeding 25% of AP dimension). Inter-observer variance was measured for each modality, and for each of these and for each foramen, consensus was reached as to whether of CMR or OMR showed better correlation with radiographs. Inter-observer variance in OMR was less (kappa=0.63) than between those of CMR and radiography (kappa=0.41). OMR can be a useful supplement in evaluating foraminal stenosis, especially when oblique radiographs and CMR images show discrepancies

  5. Bony outgrowths on the jaws of an extinct sperm whale support macroraptorial feeding in several stem physeteroids.

    Science.gov (United States)

    Lambert, Olivier; Bianucci, Giovanni; Beatty, Brian L

    2014-06-01

    Several extinct sperm whales (stem Physeteroidea) were recently proposed to differ markedly in their feeding ecology from the suction-feeding modern sperm whales Kogia and Physeter. Based on cranial, mandibular, and dental morphology, these Miocene forms were tentatively identified as macroraptorial feeders, able to consume proportionally large prey using their massive teeth and robust jaws. However, until now, no corroborating evidence for the use of teeth during predation was available. We report on a new specimen of the stem physeteroid Acrophyseter, from the late middle to early late Miocene of Peru, displaying unusual bony outgrowths along some of the upper alveoli. Considering their position and outer shape, these are identified as buccal maxillary exostoses. More developed along posterior teeth and in tight contact with the high portion of the dental root outside the bony alveoli, the exostoses are hypothesized to have developed during powerful bites; they may have worked as buttresses, strengthening the teeth when facing intense occlusal forces. These buccal exostoses further support a raptorial feeding technique for Acrophyseter and, indirectly, for other extinct sperm whales with a similar oral apparatus (Brygmophyseter, Livyatan, Zygophyseter). With a wide size range, these Miocene stem physeteroids were major marine macropredators, occupying ecological niches nowadays mostly taken by killer whales. PMID:24821119

  6. The Management of Metastatic Thyroid Carcinoma: An Initial Presentation with Bony Metastasis

    Directory of Open Access Journals (Sweden)

    Tony Y. Eng

    2011-10-01

    Full Text Available Introduction: Metastatic thyroid carcinoma presenting at the initial time of diagnosis is uncommon and the prognosis is unclear. Long term survival rates are variable ranging from 13% to 100%. This case report is presented to illustrate potential management and lend statistical power to future analysis of the correct treatment planning, mortality rates, and prognostic indications for an uncommon presentation of thyroid cancer. Case presentation: This patient is a 63 year old female who presented with new onset of progressive right hip pain. She was treated with a cortisone injection for presumed osteoarthritis but did not improve. Physical exam at the time was pertinent for a body mass index (BMI of 38.4, mild systolic hypertension, difficulty walking secondary to the right hip pain, limited range of motion at the hip, and fullness of right thyroid gland with no palpable nodules. Laboratory evaluation including thyroid function tests was normal. However, CT and MRI scans revealed a 6.5 cm × 5 cm osteolytic expansive lesion on the right iliac crest with a soft tissue mass. In addition, an enlarged right thyroid lobe and small nodular densities in the lungs suspicious for metastatic disease were noted. A fine needle aspiration of the right ileum revealed metastatic follicular adenocarcinoma consistent with a thyroid primary. The patient was not a surgical candidate due to the extent of disease. She received 37.5 Gy to both the right iliac crest mass and the neck to include the thyroid lesion, followed by iodine-131 ablation and bisphosphonate therapy. Her disease was stable on her last follow up at 48 months. Conclusion: Further studies identifying independent variables such as age of the patient, site and extent of the disease and histology of the tumor are needed to help determine the true prognosis and proper management patients with this presentation. The optimal treatment with potential chance for cure in patients with metastatic thyroid carcinoma has yet to be elucidated.

  7. Lesiones deportivas Sports injuries

    Directory of Open Access Journals (Sweden)

    Isabel Cristina Gallego Ching

    2007-04-01

    Full Text Available El estrés generado por la práctica deportiva ha originado una mayor probabilidad de que los atletas presenten lesiones agudas y crónicas. En el ámbito mundial existen diferentes investigaciones acerca de la incidencia de lesiones deportivas. La comparación de sus resultados es difícil por las diferencias en las características de la población y en la forma de reportar los datos, que varía ampliamente entre los estudios (proporciones o tasas de incidencia o tasas por cada 100 ó 1.000 participantes o tasas por horas de juego o por número de partidos jugados. Las tasas varían entre 1,7 y 53 lesiones por 1.000 horas de práctica deportiva, entre 0,8 y 90,9 por 1.000 horas de entrenamiento, entre 3,1 y 54,8 por 1.000 horas de competición y de 6,1 a 10,9 por 100 juegos. La gran variación entre las tasas de incidencia se explica por las diferencias existentes entre los deportes, los países, el nivel competitivo, las edades y la metodología empleada en los estudios. Se ha definido la lesión deportiva como la que ocurre cuando los atletas están expuestos a la práctica del deporte y se produce alteración o daño de un tejido, afectando el funcionamiento de la estructura. Los deportes de contacto generan mayor riesgo de presentar lesiones; se destacan al respecto los siguientes: fútbol, rugby, baloncesto, balonmano, artes marciales y jockey. Las lesiones ocurren con mayor probabilidad en las competencias que en el entrenamiento. Stress generated by sports practice has increased the probability that athletes suffer from acute and chronic injuries. Worldwide, there have been many different investigations concerning the incidence of sport injuries. The different ways in which results have been presented makes it difficult to compare among them. Rates of sports injuries vary between 1.7 and 53 per 1.000 hours of sports practice; 0.8 and 90.9 per 1.000 hours of training; 3.1 and 54.8 per 1.000 hours of competition, and 6.1 and 10.9 per 100 games. The great variability among the incidence rates may be explained by differences among sports, countries, competitive levels, ages and methodology used in the studies. Sports injuries have been defined as those occurring when athletes are practicing sports and that result in tissue alterations or damages, affecting the operation of the corresponding structures. Contact sports such as soccer, rugby, martial arts, basketball, handball and hockey generate greater risk of injuries. The probability of lesions is higher during competition than in training.

  8. Lesiones deportivas / Sports injuries

    Scientific Electronic Library Online (English)

    JORGE ALBERTO, OSORIO CIRO; MÓNICA PAOLA, CLAVIJO RODRÍGUEZ; ELKIN, ARANGO V; SANTIAGO, PATIÑO GIRALDO; ISABEL CRISTINA, GALLEGO CHING.

    2007-06-01

    Full Text Available El estrés generado por la práctica deportiva ha originado una mayor probabilidad de que los atletas presenten lesiones agudas y crónicas. En el ámbito mundial existen diferentes investigaciones acerca de la incidencia de lesiones deportivas. La comparación de sus resultados es difícil por las difere [...] ncias en las características de la población y en la forma de reportar los datos, que varía ampliamente entre los estudios (proporciones o tasas de incidencia o tasas por cada 100 ó 1.000 participantes o tasas por horas de juego o por número de partidos jugados). Las tasas varían entre 1,7 y 53 lesiones por 1.000 horas de práctica deportiva, entre 0,8 y 90,9 por 1.000 horas de entrenamiento, entre 3,1 y 54,8 por 1.000 horas de competición y de 6,1 a 10,9 por 100 juegos. La gran variación entre las tasas de incidencia se explica por las diferencias existentes entre los deportes, los países, el nivel competitivo, las edades y la metodología empleada en los estudios. Se ha definido la lesión deportiva como la que ocurre cuando los atletas están expuestos a la práctica del deporte y se produce alteración o daño de un tejido, afectando el funcionamiento de la estructura. Los deportes de contacto generan mayor riesgo de presentar lesiones; se destacan al respecto los siguientes: fútbol, rugby, baloncesto, balonmano, artes marciales y jockey. Las lesiones ocurren con mayor probabilidad en las competencias que en el entrenamiento. Abstract in english Stress generated by sports practice has increased the probability that athletes suffer from acute and chronic injuries. Worldwide, there have been many different investigations concerning the incidence of sport injuries. The different ways in which results have been presented makes it difficult to c [...] ompare among them. Rates of sports injuries vary between 1.7 and 53 per 1.000 hours of sports practice; 0.8 and 90.9 per 1.000 hours of training; 3.1 and 54.8 per 1.000 hours of competition, and 6.1 and 10.9 per 100 games. The great variability among the incidence rates may be explained by differences among sports, countries, competitive levels, ages and methodology used in the studies. Sports injuries have been defined as those occurring when athletes are practicing sports and that result in tissue alterations or damages, affecting the operation of the corresponding structures. Contact sports such as soccer, rugby, martial arts, basketball, handball and hockey generate greater risk of injuries. The probability of lesions is higher during competition than in training.

  9. Localization of lesions in aphasia

    International Nuclear Information System (INIS)

    Using a microcomputer, the locus and extent of the lesions, as demonstrated by computed tomography for 127 cases with various types of aphasia were superimposed onto standardized marices. The relationship between the foci of the lesions and the types of aphasia was investigated. Broca aphasics (n=39) : Since the accumulated site of the lesions highly involved the deep structures of the lower part of the precentral gyrus as well as the insula and lenticular nucleus, only 60% of the Broca aphasics had lesions on these areas. This finding has proved to have little localizing value. Wernicke aphasics (n=23) : The size of the lesion was significantly smaller than Broca's aphasia. At least 70% of the patients had the superior temporal lesions involving Wernicke's area and subcortical lesions of the superior and middle temporal gyri. Amnestic aphasics (n=18) : The size of the lesion was smaller than any other types. While there was some concentration of the lesions (maximum 40%) in the area of the subcortical region of the anterior temporal gyrus adjacent to Wernicke's area and the lenticular nucleus, the lesions were distributed throughout the left hemisphere. Amnestic aphasia was thought to be the least localizable. Conduction aphasics (n=11) : The lesions were relatively small in size. Many patients had posterior speech area lesions involving at least partially Wernicke's area. In particular, more than 80% of the conduction aphasics had lesions of the supramarginal gyrus cs had lesions of the supramarginal gyrus and it's adjacent deep structures. Global aphasics (n=36) : In general, the size of the lesion was very large and 70% of the global aphasics had extensive lesions involving both Broca's and Wernicke's areas. However, there were observations showing that the lesions can be small and confined. (J.P.N.)

  10. Importance of MRI in the diagnosis of vertebral involvement in generalized cystic lymphangiomatosis

    International Nuclear Information System (INIS)

    A 9-year-old boy presented with the sudden onset of pleuritic chest pain and on CT was found to have a large pleural effusion, mediastinal fluid, splenic lesions and multiple apparently sclerotic vertebral bodies. Subsequent MRI showed that those vertebral bodies that appeared sclerotic were in fact normal, and the vertebral bodies initially interpreted as normal had an abnormal T1 and T2 hyperintense signal on MRI and were relatively lucent on CT. MRI also demonstrated abnormal heterogeneous T2 hyperintense paraspinal tissue and several multicystic soft tissue masses. Biopsy of two adjacent vertebral bodies, one relatively sclerotic and one lucent, demonstrated findings of bony remodeling without a specific diagnosis. Biopsy of an infiltrative mediastinal mass confirmed the diagnosis of generalized cystic lymphangiomatosis. MRI should be included in the assessment of vertebral involvement in this condition because CT and biopsy findings may be nonspecific. (orig.)

  11. Importance of MRI in the diagnosis of vertebral involvement in generalized cystic lymphangiomatosis.

    Science.gov (United States)

    Renjen, Pooja; Kovanlikaya, Arzu; Narula, Navneet; Brill, Paula W

    2014-11-01

    A 9-year-old boy presented with the sudden onset of pleuritic chest pain and on CT was found to have a large pleural effusion, mediastinal fluid, splenic lesions and multiple apparently sclerotic vertebral bodies. Subsequent MRI showed that those vertebral bodies that appeared sclerotic were in fact normal, and the vertebral bodies initially interpreted as normal had an abnormal T1 and T2 hyperintense signal on MRI and were relatively lucent on CT. MRI also demonstrated abnormal heterogeneous T2 hyperintense paraspinal tissue and several multicystic soft tissue masses. Biopsy of two adjacent vertebral bodies, one relatively sclerotic and one lucent, demonstrated findings of bony remodeling without a specific diagnosis. Biopsy of an infiltrative mediastinal mass confirmed the diagnosis of generalized cystic lymphangiomatosis. MRI should be included in the assessment of vertebral involvement in this condition because CT and biopsy findings may be nonspecific. PMID:24950879

  12. Importance of MRI in the diagnosis of vertebral involvement in generalized cystic lymphangiomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Renjen, Pooja; Kovanlikaya, Arzu; Brill, Paula W. [New York Presbyterian Hospital/Weill Cornell Medical Center, Department of Radiology, New York, NY (United States); Narula, Navneet [New York Presbyterian Hospital/Weill Cornell Medical Center, Department of Pathology, New York, NY (United States)

    2014-11-15

    A 9-year-old boy presented with the sudden onset of pleuritic chest pain and on CT was found to have a large pleural effusion, mediastinal fluid, splenic lesions and multiple apparently sclerotic vertebral bodies. Subsequent MRI showed that those vertebral bodies that appeared sclerotic were in fact normal, and the vertebral bodies initially interpreted as normal had an abnormal T1 and T2 hyperintense signal on MRI and were relatively lucent on CT. MRI also demonstrated abnormal heterogeneous T2 hyperintense paraspinal tissue and several multicystic soft tissue masses. Biopsy of two adjacent vertebral bodies, one relatively sclerotic and one lucent, demonstrated findings of bony remodeling without a specific diagnosis. Biopsy of an infiltrative mediastinal mass confirmed the diagnosis of generalized cystic lymphangiomatosis. MRI should be included in the assessment of vertebral involvement in this condition because CT and biopsy findings may be nonspecific. (orig.)

  13. Aggressive Ewing's sarcoma appearing as a cold lesion on bone scan

    International Nuclear Information System (INIS)

    Ewing's sarcoma classically presents as a hot spot on bone scan as a result of increased vascularity of the tumor and new bone formation. Purpose We report and analyze an uncommon pattern of a 'cold' lesion in Ewing's sarcoma on bone scan and its pathophysiologic significance. Case report A 15-year-old boy complaining of thigh pain. CT scan evoked Ewing's sarcoma or osteitis. MRI evoked chronic osteitis. Scintigraphy showed a fairly intense and heterogeneous uptake on the femoral lesion and no abnormal uptake elsewhere. Biopsy showed none pathologic pattern. Three months later, a second biopsy concluded to Ewing's sarcoma. Bone scan showed a larger lesion with peripheral intense uptake centered by enlarged 'cold' area in the left femoral diaphysis and no evident bone metastasis. The patient underwent chemotherapy and surgery. Three months later, bone scan showed extensive skeletal metastasis. Conclusion Ewing's sarcoma appears usually as an intense lesion on bone scan. Nevertheless, decreased radiopharmaceutical uptake or 'cold' lesion may be seen in aggressive Ewing's sarcoma with lytic tumor, growth of which is very rapid and bony reaction is minimal. (authors)

  14. Acute nontraumatic liver lesions

    OpenAIRE

    Caremani, Marcello; Tacconi, Danilo; Lapini, Laura

    2013-01-01

    The principal conditions requiring emergency/urgent intervention in patients with nontraumatic liver lesions are hemorrhage (with or without tumor rupture), rupture of hydatid cysts (with or without infection), complications arising from liver abscesses or congenital liver cysts, rupture related to peliosis hepatis, and in rare cases spontaneous hemorrhage. This article examines each of these conditions, its appearance on ultrasound (the first-line imaging method of choice for assessing any u...

  15. Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions

    International Nuclear Information System (INIS)

    Aim: The aim of this study is to evaluate the value of the apparent diffusion coefficient (ADC) obtained in diffusion-weighted (DW) MR sequences for the differentiation between malignant and benign bone marrow lesions. Method: Forty-five patients with altered signal intensity vertebral bodies on conventional MR sequences were included. The cause of altered signal intensity was benign osteoporotic collapse in 16, acute neoplastic infiltration in 15, and infectious processes in 14; based on plain-film, CT, bone scintigraphy, conventional MR studies, biopsy or follow-up. All patients underwent isotropic DW MR images (multi-shot EPI, b values of 0 and 500 s/mm2). Signal intensity at DW MR images was evaluated and ADC values were calculated and compared between malignancy, benign edema and infectious spondylitis. Results: Acute malignant fractures were hyperintense compared to normal vertebral bodies on the diffusion-weighted sequence, except in one patient with sclerotic metastases. Mean ADC value from benign edema (1.9 ± 0.39 x 10-3 mm2/s) was significantly (p -3 mm2/s). Mean ADC value of infectious spondilytis (0.96 ± 0.49 x 10-3 mm2/s) was not statistically (p > 0.05) different from untreated metastasic lesions. ADC value was low (0.75 x 10-3 mm2/s) in one case of subacute benign fracture. Conclusions: Aubacute benign fracture. Conclusions: ADC values are a useful complementary tool to characterize bone marrow lesions, in order to distinguish acute benign fractures from malignant or infectious bone lesions. However, ADC values are not valuable in order to differentiate malignancy from infection.

  16. Accuracy of CT-guided biopsies in 158 patients with thoracic spinal lesions

    Energy Technology Data Exchange (ETDEWEB)

    Hao, D.J.; He, B.R.; Liu, T.J.; Zhao, Q.P. (Dept. of Spinal Surgery, Xian Red Cross Hospital, Xian Shaanxi (China)), email: zqpddn1@gmail.com; Sun, H.H. (Dept. of Orthopaedic, Tangdu Hospital, Fourth Military Medical Univ., Xian Shaanxi (China)); Jiang, Y.H. (Dept. of Radiology, Xian Red Cross Hospital, Xian Shaanxi (China))

    2011-11-15

    Background. Inconsistent accuracies of CT-guided thoracic spinal biopsies have been reported in previous studies. Purpose. To determine the accuracy of CT-guided thoracic spinal biopsy, to compare the results with those previously reported, and to determine if there are any factors that influence the accuracy of CT-guided thoracic spinal biopsy. Material and Methods. In total, 158 consecutive CT-guided percutaneous thoracic spine procedures (performed at the Dept. of Spinal Surgery, Xian Red Cross Hospital between April 2000 and July 2010) were reviewed. The 158 lesions were categorized by location and radiographic features. Pathological and clinical follow-up were used to determine accuracy. Results. The diagnostic accuracy of CT-guided thoracic spinal biopsy was 90.5% overall. Biopsy of metastatic bone disease (98.2%) was significantly more accurate than biopsies of primary tumors (80.9%) and of hematological malignancies (47.0%) (P < 0.05 and P < 0.005, respectively). The diagnostic accuracy of CT-guided thoracic spinal biopsy was significantly higher for the lower thoracic spine (97.6%) than for the middle (90.0%) or upper thoracic spine (80.4%) (P < 0.05 and P < 0.025, respectively). The diagnostic accuracy was significantly higher for lytic lesions (96.4%) than for sclerotic lesions (81.3%) (P < 0.010). The accuracy of biopsies performed using the transpedicular approach (91.0%) was not significantly different from that of biopsies performed using posterolateral approaches (91.5%) (0.25 < P < 0.5). Conclusion. Percutaneous CT-guided thoracic spinal biopsy is a viable alternative to open surgical biopsy. The diagnostic accuracy was not affected by any of the variables except for lesion level, histology, and radiographic features

  17. A Diphenol Oxidase Gene Is Part of a Cluster of Genes Involved in Catecholamine Metabolism and Sclerotization in Drosophila. II. Molecular Localization of the Dox-A2 Coding Region

    OpenAIRE

    Pentz, Ellen Steward; Wright, Theodore R. F.

    1986-01-01

    Mutations at the Dox-A2 (2-53.9) locus alter the A2 component of diphenol oxidase, an enzyme having an important role in cuticle formation. This locus is in the dopa decarboxylase, Df( 2L)TW130 region, which contains a cluster of at least 14 genes involved in catecholamine metabolism and the formation, sclerotization and melanization of cuticle in Drosophila. The region is subdivided by deficiencies, and localization of breakpoints in cloned DNA reveals a dense subcluster of six genes in the ...

  18. Intravascular lesions of the hand

    OpenAIRE

    Duke Wayne H; Pantanowitz Liron

    2008-01-01

    Abstract Introduction Intravascular lesions of the hand comprise reactive and neoplastic entities. The clinical diagnosis of such lesions is often difficult, and usually requires pathologic examination. We present the largest series to date of intravascular lesions affecting the hand. Methods A retrospective review of intravascular (arterial and venous) lesions involving the hand was conducted. Data regarding clinicopathologic findings were analyzed. Results We identified 10 patients with int...

  19. Clinical Evaluation of Positioning Verification Using Digital Tomosynthesis and Bony Anatomy and Soft Tissues for Prostate Image-Guided Radiotherapy

    International Nuclear Information System (INIS)

    Purpose: To evaluate on-board digital tomosynthesis (DTS) for patient positioning vs. two-dimensional (2D) radiography and three-dimensional cone beam (CBCT). Methods and Materials: A total of 92 image sessions from 9 prostate cancer patients were analyzed. An on-board image set was registered to a corresponding reference image set. Four pairs of image sets were used: digitally reconstructed radiographs vs. on-board orthogonal paired radiographs for the 2D method, coronal-reference DTS vs. on-board coronal DTS for the coronal-DTS method, sagittal-reference DTS vs. on-board sagittal DTS for the sagittal-DTS method, and planning CT vs. CBCT for the CBCT method. The registration results were compared. Results: The systematic errors in all methods were o. When registering the bony anatomy, the mean vector difference was 0.21 ± 0.11 cm between 2D and CBCT, 0.11 ± 0.08 cm between CBCT and coronal DTS, and 0.14 ± 0.07 cm between CBCT and sagittal DTS. The correlation between CBCT to DTS was stronger (coefficient = 0.92-0.95) than the correlation between 2D and CBCT or DTS (coefficient = 0.81-0.83). When registering the soft tissue, the mean vector difference was 0.18 ± 0.11 cm between CBCT and coronal DTS and 0.29 ± 0.17 cm between CBCT and sagittal DTS. The correlation coefficient of CBCT to sagittal DTS and to coronal DTS was 0.84 and 0.92, respectively. Conclusion: DTS could provide equivalent results to CBCT when the bony anatomy is used as landmarn the bony anatomy is used as landmarks for prostate image-guided radiotherapy. For soft tissue-based positioning verification, coronal DTS produced equivalent results to CBCT, but sagittal DTS alone was insufficient. DTS could allow for comparable soft tissue-based target localization with faster scanning time and a lower imaging dose compared with CBCT

  20. A disappearing neonatal skin lesion.

    LENUS (Irish Health Repository)

    Hawkes, Colin Patrick

    2012-01-31

    A preterm baby girl was noted at birth to have a firm, raised, non-tender skin lesion located over her right hip. She developed three similar smaller lesions on her ear, buttock and right knee. All lesions had resolved by 2 months of age.

  1. Analysis of pulmonary coin lesions

    Energy Technology Data Exchange (ETDEWEB)

    Kim, O; Kim, K. H.; Oh, K. K.; Park, C. Y. [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    1979-06-15

    For A long time the solitary pulmonary nodule has remained a difficult problem to solve and has attracted a great deal of attension in recent years. Circumscribed coin lesions of the lung were generally peripheral in location with respect to the pulmonary hilus. Because of this, important clinical problem in management and diagnosis arise. Such a lesion is discovered through roentgenologic examination. So the roentgenologists is the first be in a position to offer advise. This presentation is an attempt to correlate a useful diagnosis with roentgenologic findings of pulmonary coin lesion which enables us to get differential diagnosis of benign and malignant lesion. Histologically proven 120 cases of the pulmonary coin lesion during the period of 8 years were reviewed through plain film, tomogram, bronchoscopy, variable laboratory findings, and clinical history. The results are as follows: 1. Male to female sex ratio was 3 : 1. In age distribution, most of the malignant pulmonary coin lesion appeared in 6th decade (39%) and 5th decade (27%). In benign lesion, the most cases were in 3 rd decade. 2. Pathological cell type are as follows: Primary bronchogenic cancer 43.3%, tuberculoma 25.8%, inflammatory lesion 17.5%, benign tumor 10%, and bronchial adenoma, harmartoma, A.V. malformation, mesothelioma, are 1 case respectively. As a result benign and malignant lesion showed equal distribution (49.1% : 50.3%). 3. In symptom analysis ; cough is the most common (43.5%) symptom in malignant lesion, next follows hemoptysis (20.9%) and chest pain (14.5%). In benign lesion, most of the patient (32.7%) did not complain any symptom. 4. In malignant lesion, the most common nodular size was 4 cm (32.3%), and in benign lesion 2 cm sized coin was most common (39.3%). 5. In general, margin of nodule was very sharp and well demarcated in benign lesion (83.3%), and in malignant lesion that was less demarcated and poorly defined. 6. Most case of calcification (82.7%) was seen in benign lesion, and the most common type is central nidus. 7. Cavitary lesion (12.5%) of thick walled irregular margin with eccentric location in the coin lesion is indicative of malignant coin lesion. 8. Stellate lesion was 7 cases and all of them were seen in tuberculomas.

  2. [Chorioretinal lesions in deaf mutes].

    Science.gov (United States)

    State, A; Mocanu, C

    2000-01-01

    The paper reports a study of 216 patients of special deaf-mute schools from Craiova. The exam of them showed us the presence of retinal degenerative lesions in 17 cases (7.8%). There was not a parallelism between deafness' degree and retinal lesions expanse. In point of clinical aspect, the retinal degenerative lesions were Sjögreen retinal lesions in 6 cases, colloidal Amalric-Bessou retinal lesions in 6 cases. In 2 cases lesions had a pseudoinflammatory aspect and another 2 cases were peripheral lesions like "salt and pepper's". Only one case had pigmentary osteoblastic mobilization. Deafness was associated with oligophrenia in 15 cases, with discreet manifestations of eredoataxia Friedreich in 5 cases, with epilepsy in 2 cases and with nanism in another 2 cases. It is necessary a complex oto-neuro-ophthalmological exploration of patients with deaf-muteness. PMID:11021119

  3. Klatskin-like lesions.

    Science.gov (United States)

    Senthil Kumar, M P; Marudanayagam, R

    2012-01-01

    Hilar cholangiocarcinoma, also known as Klatskin tumour, is the commonest type of cholangiocarcinoma. It poses unique problems in the diagnosis and management because of its anatomical location. Curative surgery in the form of major hepatic resection entails significant morbidity. About 5-15% of specimens resected for presumed Klatskin tumour prove not to be cholangiocarcinomas. There are a number of inflammatory, infective, vascular, and other pathologies, which have overlapping clinical and radiological features with a Klatskin tumour, leading to misinterpretation. This paper aims to summarise the features of such Klatskin-like lesions that have been reported in surgical literature. PMID:22811587

  4. A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in drosophila. I. Identification of the biochemical defect in Dox-A2 [l(2)37Bf] mutants.

    Science.gov (United States)

    Pentz, E S; Black, B C; Wright, T R

    1986-04-01

    Phenol oxidase, a complex enzyme, plays a major role in the processes of sclerotization and melanization of cuticle in insects. Several loci have been reported to affect levels of phenol oxidase activity, but to date only one structural locus has been identified [Dox-3F (2-53.1+)]. Recently isolated Dox-A2 mutations (2-53.9) are recessive, early larval lethals, which as heterozygotes reduce phenol oxidase activity. A homozygous mutant escaper had weak, completely unpigmented cuticle and unpigmented bristles. Enzyme assays show that Dox-A2 heterozygotes have diphenol oxidase activity reduced to 47-79% of wild type, whereas monophenol oxidase activity, at 94-106% of wild type, is normal. Elevated pool sizes of the diphenol oxidase substrates DOPA, dopamine, and N-acetyldopamine are observed in the mutant, confirming the enzyme assay results. Separation of the three phenol oxidase A component activities on polyacrylamide gels shows that Dox-A2 mutations reduce the activity of only the A2 component. Dox-A2 may identify a structural locus for the A2 component of the diphenol oxidase enzyme system. The Dox-A2 locus is one of 18 loci in the dopa decarboxylase, Df (2L)TW130 region of the second chromosome, at least 14 of which affect the formation, melanization or sclerotization of cuticle in some way. These loci form an apparent cluster of functionally related genes. PMID:3082714

  5. Development of efficient electron beam irradiating condition of artificial bone substitutes with 7 to 3 ratio of hydroxyapatite, tricalcium phosphate and type I collagen to maximize bony regeneration

    International Nuclear Information System (INIS)

    Bony defects in oral and maxillofacial region was a common problem -Auto graft -Allograft -Xenograft. Accenting bone is 'Gold standard' for bone defect repair and from the rib, iliac crest, jaw and tibia. Bone is 70% inorganic components -which provide firmness, and approx. and 30% organic substances

  6. Radiographic features of large cystic lesions of the jaws in children

    International Nuclear Information System (INIS)

    The surgical approach to cystic lesions of the jaws is either marsupialisation or enucleation. The treatment of choice is dependent on the size of the lesion, the bony integrity of the cyst and its proximity to anatomical structures.Objectives. To assess large (>2.0 cm) cystic lesions of the jaws using plain film radiography (PFR), CT, multiplanar reconstruction program (MPR) and three-dimensional CT (3D-CT).Patients and methods. Twelve children aged 7-14 years.Results. The classic radiological feature was a unilocular radiolucent area surrounded by a well-defined radio-opaque margin adjacent to the root of a non-viable tooth or associated with the crown of an unerupted tooth. Malposition of teeth and root resorption were more common in dentigerous cysts. The features seen on CT were clear and more precise than those seen on PFR. MPR, by the three-dimensional visualisation of the jaw (axial, panoramic, and bucco-lingual), provided useful information for determining the outline of the cyst and its proximity to adjacent anatomical structures, such as teeth, nerves or maxillary sinus. 3-D CT further and more clearly demonstrated discontinuity in the buccal or palatal/lingual cortices of the jaw bone. PFR was very accurate in determining root resorption.Conclusions. CT with MPR and, ideally, 3-D CT should be used for the comprehensive diagnostic work-up and meticulous surgical management of large cystic lesions of the jaws in children. (orig.)dren. (orig.)

  7. The significance of a hypoplastic bony canal for the cochlear nerve in patients with sensorineural hearing loss: CT and MRI findings

    International Nuclear Information System (INIS)

    The purpose of this study is to evaluate the significance of the hypoplastic canal for the cochlear nerve in patients with sensorineural hearing loss (SNHL) and the relationship between the hypoplastic bony canal and aplasia or hypoplasia of the cochlear nerve. A retrospective review of high resolution temporal CT(HRCT) and MRI findings was conducted. The narrow bony canal of the cochlear nerve and the relative size of the internal auditory canal were correlated with the cochlear nerve deficiency on MRI. The comparative size of the component nerves (facial, cochlear, superior vestibular, inferior vestibular nerve), and the relative size of the internal auditory canal and the bony canal of the cochlear nerve were measured. The clinical history and the results of the clinical examination were reviewed for each patient. High resolution MRI showed aplasia of the common vestibulocochlear nerve in one patient and a deficiency of the cochlear nerve in 9 patients. These abnormalities occurred in association with a prominent narrowing of the canal for the cochlear nerve and a stenosis of the internal auditory canal, which was observed on temporal bone CT in 9 patients with congenital SNHL. Three patients had normal IAC, despite the presence of a hypoplastic cochlear nerve on the side on which they had SNHL. In one patient, the narrowing of the canal for the cochlear nerve and internal auditory canal were not found to be associated with acquired SNHL. The hypoplastic bony canal acquired SNHL. The hypoplastic bony canal for the cochlear nerve might be more highly indicative of congenital cochlear nerve deficiency than that of the narrow internal auditory canal, and the position of the crista falciformis should also be carefully

  8. Air CT cisternography in cases with retrolabyrinthine lesion

    International Nuclear Information System (INIS)

    Imaging of the cerebellopontine angle structures by means of air CT cisternography was studied in cases with suspected retrolabyrinthine lesions. The method of air CT cisternography in our study was characterized by air infusion through a suboccipital route and by imaging of both cerebellopontine angles in one study. Ninety cases have been studied so far. Four cases of small acoustic tumors, including two cases of intracanalicular tumors, were found. Additionally, one case of small meningioma in the porus was detected. The percentage of the detection of small acoustic tumors in our series was significantly low. However, various abnormalities other than neoplasms were revealed. An enlargement of the acoustic canal without a tumor was found in five cases; this abnormality was usually bilateral. This structural abnormality corresponds to the patulous canal or dural ectasia of the canal described in the previous literature, which was believed to be one of characteristics of bony changes in Recklinghausen's disease. Only one case in our series, however, had the definite stigmata of Recklinghausen's disease. The present authors designate this canal enlargement ''empty meatus''; it seems to be a new clinical entity. An irregular thickening of the nerve and a nodular appearance of the nerve in the canal were found in the case of Recklinghausen's disease. A diagnosis of localized arachnoiditis was made in three cases, and that of a primary atrophy of the acoustic nerve, in one case. (author)

  9. Anatomical and Bone Scintigraphy Radiology: Report of the Overlap of Images in the Therapeutic Approach to Bone Lesions

    International Nuclear Information System (INIS)

    Conventional radiology, Rx simple or tomographic studies is part of the initial study of bone lesions or suspicion of them in the daily management of patients. The bone scan is a procedure widely used as an adjunct to diagnosis in extensive study of these cases, providing global skeletal metabolic information, which mainly includes the diagnosis of skeletal metastases in malignant tumors. Objective: To evaluate the overlap of anatomical and functional images in the medical management of surgical bone lesions. Materials and methods: Prospectively included 40 patients of various age groups, referred to Gamanuclear Ltd from October 2005 to April 2007, which were studied by bony growths (35) or suspected of same by focusing painful symptomatology (5). All patients had radiological studies. The bony scintigraphy were performed 3-4 hours after intravenous injection of a diagnostic dose of 99mTc MDP. The gamacamaras used was a GE XRT and other SMV Power Vision, and the overlap of images is done with Corel draw, screen hunter and Scion image

  10. Nonsurgical management of periapical lesions

    Directory of Open Access Journals (Sweden)

    Fernandes Marina

    2010-01-01

    Full Text Available Periapical lesions develop as sequelae to pulp disease. They often occur without any episode of acute pain and are discovered on routine radiographic examination. The incidence of cysts within periapical lesions varies between 6 and 55%. The occurrence of periapical granulomas ranges between 9.3 and 87.1%, and of abscesses between 28.7 and 70.07%. It is accepted that all inflammatory periapical lesions should be initially treated with conservative nonsurgical procedures. Studies have reported a success rate of up to 85% after endodontic treatment of teeth with periapical lesions. A review of literature was performed by using electronic and hand searching methods for the nonsurgical management of periapical lesions. Various methods can be used in the nonsurgical management of periapical lesions: the conservative root canal treatment, decompression technique, active nonsurgical decompression technique, aspiration-irrigation technique, method using calcium hydroxide, Lesion Sterilization and Repair Therapy, and the Apexum procedure. Monitoring the healing of periapical lesions is essential through periodic follow-up examinations.

  11. A new species of Hyphessobrycon (Teleostei: Characidae) from the upper rio Tocantins drainage, with bony hooks on fins

    Scientific Electronic Library Online (English)

    Vinicius A., Bertaco; Luiz R., Malabarba.

    2005-03-01

    Full Text Available Uma nova espécie de caracídeo, Hyphessobrycon hamatus é descrita para os tributários do alto rio Tocantins, Goiás, Brasil. A nova espécie distingue-se das demais espécies de Hyphessobrycon pela presença de ganchos nos raios das nadadeiras dorsal, anal, pélvica e peitoral dos machos, duas manchas ume [...] rais pretas verticalmente alongadas, 4-5 dentes na série interna do pré-maxilar, 2-3 dentes no maxilar, 16-18 raios ramificados na nadadeira anal, 10-32 escamas perfuradas na linha lateral, e 33-35 escamas em uma série longitudinal. Abstract in english A new species of characid, Hyphessobrycon hamatus, is described from the upper rio Tocantins, Goiás, Brazil. The new species is distinguished from all other Hyphessobrycon species by the presence of bony hooks on dorsal, anal, pelvic, and pectoral fins of males, the two black humeral spots, the 4 or [...] 5 teeth in the inner series of the premaxilla, a maxilla with 2-3 teeth, the iii-v, 16-18 anal-fin rays, and a lateral line with 10-32 perforated scales and 33-35 scales in a longitudinal series.

  12. A new species of Hyphessobrycon (Teleostei: Characidae from the upper rio Tocantins drainage, with bony hooks on fins

    Directory of Open Access Journals (Sweden)

    Vinicius A. Bertaco

    2005-03-01

    Full Text Available A new species of characid, Hyphessobrycon hamatus, is described from the upper rio Tocantins, Goiás, Brazil. The new species is distinguished from all other Hyphessobrycon species by the presence of bony hooks on dorsal, anal, pelvic, and pectoral fins of males, the two black humeral spots, the 4 or 5 teeth in the inner series of the premaxilla, a maxilla with 2-3 teeth, the iii-v, 16-18 anal-fin rays, and a lateral line with 10-32 perforated scales and 33-35 scales in a longitudinal series.Uma nova espécie de caracídeo, Hyphessobrycon hamatus é descrita para os tributários do alto rio Tocantins, Goiás, Brasil. A nova espécie distingue-se das demais espécies de Hyphessobrycon pela presença de ganchos nos raios das nadadeiras dorsal, anal, pélvica e peitoral dos machos, duas manchas umerais pretas verticalmente alongadas, 4-5 dentes na série interna do pré-maxilar, 2-3 dentes no maxilar, 16-18 raios ramificados na nadadeira anal, 10-32 escamas perfuradas na linha lateral, e 33-35 escamas em uma série longitudinal.

  13. Aggressive Ewing's sarcoma appearing as a cold lesion on bone scan; Sarcome d'Ewing agressif apparaissant comme une lesion froide sur la scintigraphie osseuse

    Energy Technology Data Exchange (ETDEWEB)

    Chatti, K.; Guezguez, M.; Maha Ben Fredj, M.; Sfar, R.; Essabbah, H. [Hopital Universitaire de Sahloul, Dept. de Medecine Nucleaire, Sahloul (Tunisia); Mtaoumi, M. [Hopital Universitaire de Sahloul, Dept. d' Orthopedie, Sousse (Tunisia); Chatti, K. [Faculte de Medecine de Monastir, Lab. de Biophysique, Monastir (Tunisia)

    2009-10-15

    Ewing's sarcoma classically presents as a hot spot on bone scan as a result of increased vascularity of the tumor and new bone formation. Purpose We report and analyze an uncommon pattern of a 'cold' lesion in Ewing's sarcoma on bone scan and its pathophysiologic significance. Case report A 15-year-old boy complaining of thigh pain. CT scan evoked Ewing's sarcoma or osteitis. MRI evoked chronic osteitis. Scintigraphy showed a fairly intense and heterogeneous uptake on the femoral lesion and no abnormal uptake elsewhere. Biopsy showed none pathologic pattern. Three months later, a second biopsy concluded to Ewing's sarcoma. Bone scan showed a larger lesion with peripheral intense uptake centered by enlarged 'cold' area in the left femoral diaphysis and no evident bone metastasis. The patient underwent chemotherapy and surgery. Three months later, bone scan showed extensive skeletal metastasis. Conclusion Ewing's sarcoma appears usually as an intense lesion on bone scan. Nevertheless, decreased radiopharmaceutical uptake or 'cold' lesion may be seen in aggressive Ewing's sarcoma with lytic tumor, growth of which is very rapid and bony reaction is minimal. (authors)

  14. Multiple bony metastases of breast cancer. Role of CA 15.3 and response to hormone therapy

    International Nuclear Information System (INIS)

    Bone metastases are involved in a 65-75% of advanced metastatic breast cancer cases. Tumoral markers (CEA, CA 15.3) are useful in the follow-up and evaluation of response to treatment. Hormonal therapy is the optimal treatment option in low grade metastatic breast cancer due to low toxicity and general long term good response. We present a breast cancer case treated with surgery, chemotherapy and radiotherapy. The patient was asymptomatic during the follow-up and multiple bone metastases were diagnosed as a result of an increased CA 15.3 marker found. Hormone therapy was the recommended initial treatment with good response and tolerance. Bone lesions remained stabilized for 7 years but after treatment suspension new bone lesions appeared. CA 15.3 marker had increased again. Reintroduction of hormonal therapy achieved again the stabilization of the lesions

  15. Crown amputation with intentional root retention for advanced feline resorptive lesions--a clinical study.

    Science.gov (United States)

    DuPont, G

    1995-03-01

    Whole tooth extraction is generally considered to be the treatment of choice for teeth with advanced feline external odontoclastic resorptive lesions. These teeth often have both a weakened, brittle crown and radicular ankylosis. These two factors cause frustration and sometimes complications during attempts at extraction. This study investigated the alternative of intentionally leaving part or all of non-pathologic tooth roots in situ to prevent iatrogenic trauma to the patient, loss of alveolar bone, and prolonged healing of surgical defects. Fifty one roots from 23 teeth were radiographed 5-36 months following elective root retention; continued resorption without surrounding bony reaction was seen in almost all cases. In one cat, the roots retained normal periodontal ligament one year later, and in another cat that developed severe stomatitis, the intentionally retained roots were extracted at the same time that the remaining molar teeth were extracted. PMID:9693619

  16. Space-occupying, inflammatory and dyplastic lesions of the cranio-cervical junction seen in nuclear magnetic resonance imaging (MRI)

    International Nuclear Information System (INIS)

    Lesions of the cranio-cervical junction have acquired a special place amongst lesions of the posterior cranial fossa and the upper cervical region. This is due to the unusually long period between the appearance of the first symptoms and reaching a conclusive diagnosis. Frequently such lesions cannot be detected by either normal X-rays or conventional tomographic techniques. The introduction, however, of computer tomography (CT) and, in particular, magnetic resonance imaging (MRI) has made the examination of the critical zone of the cranio-cervical junction much easier and the diagnosis of thee lesions has now become largely dependent upon those techniques. Because soft tissue contrast is intrinsic to MRI this technique, in particular, has made possible substantial improvements in the quality of images of ligaments and soft tissue than those provided by standard CT. In this paper, the advantages which are provided by MRI in the context of the diagnosis of non-bony lesions in the cranio-cervical region are presented and discussed

  17. MRI in suspicious breast lesions

    International Nuclear Information System (INIS)

    Purpose: The value of MRI in the detection and handling of oncologic pathology. Multifocality and multi centricity. Re-evaluation of post-surgical breast. Material and methods: 18 female patients (age ranged between 35-79 years, mean age 52 years) were studied with MRI under suspicion of neoplastic breast lesions. In 16 patients stereotactic automated large core-biopsies as well as surgical biopsies were performed. Results: From the 18 patients studied with MRI, 9 (50%) had palpable lesions, 5 (28%) had no palpable lesions (infra-clinical), and 4 patients (22%) post-surgical changes. 16 patients underwent surgical or core-biopsies, and 2 patients are under a follow up protocol. In 6 patients (33%) with palpable lesions MRI findings correlated well with surgical biopsies. In 2 patients with palpable nodular lesions and pathological enhancement in MRI one had a cancer and the other had a post-surgical fibrosis. In 4 patients with infra clinical lesions, MRI showed multifocal or multi centrical lesions in 3 (16%) and post-surgical changes in 1 (5%). We had 3 false positives: one patient with a palpable nodular lesion, one patient with a non palpable lesion and one case with abnormal area of gadolinium enhancement, that not represented the localization of the tumor at surgery. Conclusion: Substraction dynamic MRI has been able to detect primary occult tumors and multi centricity/multifocality, changing the surgical planning in the management of breast cancer. Post-surgica management of breast cancer. Post-surgical breast evaluation is always difficult, but in some cases MRI established the presence of local recurrence confirmed by the pathologist after surgical or core-biopsies. (author)

  18. Demonstration of pseudorabies virus DNA in the mouse inner ear by an in situ nucleic acid hybridization technique in plastic embedded bony material

    OpenAIRE

    Falser, N.; Bandtlow, I.; Hausmann, M.; Wolf, Hans J.

    1986-01-01

    This investigation is concerned with the possibility of identifying viral DNA using the in situ DNA hybridization method in methylmethacrylate-embedded material. As an experimental model we chose viral labyrinthitis produced by intranasal infection of the mouse with pseudorabies virus. Fixation and embedding methods specially adapted to this procedure and bony histology preparation technique (specimens by grinding or micromilling) made it possible to identify viral DNA directly morphologicall...

  19. Evaluation of pelvic lymph node coverage of conventional radiotherapy fields based on bony landmarks in Chinese cervical cancer patients using CT simulation

    OpenAIRE

    Zhang, Xiang; Yu, Hua

    2009-01-01

    Objective: To evaluate the pelvic lymph node coverage of conventional pelvic fields based on bony landmarks in Chinese patients with cervical cancer by using computed tomography (CT) simulation images to contour pelvic vessels as substitutes for lymph nodes location. Methods: A retrospective review of CT simulation images and conventional pelvic radiation planning data sets was performed in 100 patients with cervical cancer at the International Federation of Gynecology and Obstetrics (FIGO) S...

  20. Development of mandibular, hyoid and hypobranchial muscles in the zebrafish: homologies and evolution of these muscles within bony fishes and tetrapods

    OpenAIRE

    Hinits Yaniv; Diogo Rui; Hughes Simon M

    2008-01-01

    Abstract Background During vertebrate head evolution, muscle changes accompanied radical modification of the skeleton. Recent studies have suggested that muscles and their innervation evolve less rapidly than cartilage. The freshwater teleostean zebrafish (Danio rerio) is the most studied actinopterygian model organism, and is sometimes taken to represent osteichthyans as a whole, which include bony fishes and tetrapods. Most work concerning zebrafish cranial muscles has focused on larval sta...

  1. The significance of a hypoplastic bony canal for the cochlear nerve in patients with sensorineural hearing loss: CT and MRI findings

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yoon Jung; Park, Sang Yoo; Kim, Myung Soon; Sung, Ki Jun [College of Medicine, Yonsei Univ., Wonju (Korea, Republic of)

    2004-04-01

    The purpose of this study is to evaluate the significance of the hypoplastic canal for the cochlear nerve in patients with sensorineural hearing loss (SNHL) and the relationship between the hypoplastic bony canal and aplasia or hypoplasia of the cochlear nerve. A retrospective review of high resolution temporal CT(HRCT) and MRI findings was conducted. The narrow bony canal of the cochlear nerve and the relative size of the internal auditory canal were correlated with the cochlear nerve deficiency on MRI. The comparative size of the component nerves (facial, cochlear, superior vestibular, inferior vestibular nerve), and the relative size of the internal auditory canal and the bony canal of the cochlear nerve were measured. The clinical history and the results of the clinical examination were reviewed for each patient. High resolution MRI showed aplasia of the common vestibulocochlear nerve in one patient and a deficiency of the cochlear nerve in 9 patients. These abnormalities occurred in association with a prominent narrowing of the canal for the cochlear nerve and a stenosis of the internal auditory canal, which was observed on temporal bone CT in 9 patients with congenital SNHL. Three patients had normal IAC, despite the presence of a hypoplastic cochlear nerve on the side on which they had SNHL. In one patient, the narrowing of the canal for the cochlear nerve and internal auditory canal were not found to be associated with acquired SNHL. The hypoplastic bony canal for the cochlear nerve might be more highly indicative of congenital cochlear nerve deficiency than that of the narrow internal auditory canal, and the position of the crista falciformis should also be carefully.

  2. Implante de biomateriais e a consolidação óssea em cadelas submetidas à ovariossalpingo-histerectomia / Influence of biomaterials on the bony consolidation in spayed female dogs

    Scientific Electronic Library Online (English)

    A.I., Roque-Rodriguez; S.M., Baraldi-Artoni; D., Oliveira.

    1054-10-01

    Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Avaliou-se a hidroxiapatita com alandronato e hidroxiapatita com colágeno na aceleração da consolidação óssea do rádio de cadelas adultas submetidas à ovariossalpingo-histerectomia (OSH). Utilizaram-se 14 cadelas adultas, distribuídas aleatoriamente em dois grupos: grupo-controle e grupo OSH (submet [...] idas à OSH). Quatro meses após a OSH, as cadelas dos dois grupos foram submetidas à cirurgia para produção de uma falha óssea de 4mm de diâmetro nos terços distal e proximal do rádio. No terço distal do membro direito, foi utilizada a hidroxiapatita com alandronato e, no membro esquerdo, a hidroxiapatita com colágeno; no terço proximal, não se utilizou nenhum biomaterial. Houve retardo na consolidação das falhas ósseas nas cadelas submetidas à OSH comparadas com as não submetidas. A hidroxiapatita com alandronato acelerou o processo de reparação e, em todos os animais dos dois grupos, a densidade óssea foi significativamente maior no terço distal onde foi implantada. Os dois biomateriais apresentaram biocompatibilidade, constatada pela ausência de reação inflamatória ou outra reação indesejável. Abstract in english The hydroxyapatite with alendronate and hydroxyapatite with collagen were evaluated in the acceleration of the bony consolidation of adult spayed bitch radius. For that, 14 adult bitches were distributed in two groups (control and spayed). Four months after ovariohysterectomy, the groups were submit [...] ted to the surgery for production of a 4mm diameter bony flaw in the distal and proximal third regions of the radius. In the distal region of the right thoracic limb, hydroxyapatite with alendronate was used. In the distal region of the left thoracic limb, hydroxyapatite with collagen was used. Any biomaterial was used in proximal part of the limb. There was a retard in bony flaws consolidation in the spayed bitches. Hydroxyapatite with alendronate showed better result, since the place it was implanted considerably increased the bony formation. Both biomaterials presented biocompatibility, verified by the absence of inflammatory reaction or other undesirable reaction.

  3. Implante de biomateriais e a consolidação óssea em cadelas submetidas à ovariossalpingo-histerectomia Influence of biomaterials on the bony consolidation in spayed female dogs

    Directory of Open Access Journals (Sweden)

    A.I. Roque-Rodriguez

    2009-10-01

    Full Text Available Avaliou-se a hidroxiapatita com alandronato e hidroxiapatita com colágeno na aceleração da consolidação óssea do rádio de cadelas adultas submetidas à ovariossalpingo-histerectomia (OSH. Utilizaram-se 14 cadelas adultas, distribuídas aleatoriamente em dois grupos: grupo-controle e grupo OSH (submetidas à OSH. Quatro meses após a OSH, as cadelas dos dois grupos foram submetidas à cirurgia para produção de uma falha óssea de 4mm de diâmetro nos terços distal e proximal do rádio. No terço distal do membro direito, foi utilizada a hidroxiapatita com alandronato e, no membro esquerdo, a hidroxiapatita com colágeno; no terço proximal, não se utilizou nenhum biomaterial. Houve retardo na consolidação das falhas ósseas nas cadelas submetidas à OSH comparadas com as não submetidas. A hidroxiapatita com alandronato acelerou o processo de reparação e, em todos os animais dos dois grupos, a densidade óssea foi significativamente maior no terço distal onde foi implantada. Os dois biomateriais apresentaram biocompatibilidade, constatada pela ausência de reação inflamatória ou outra reação indesejável.The hydroxyapatite with alendronate and hydroxyapatite with collagen were evaluated in the acceleration of the bony consolidation of adult spayed bitch radius. For that, 14 adult bitches were distributed in two groups (control and spayed. Four months after ovariohysterectomy, the groups were submitted to the surgery for production of a 4mm diameter bony flaw in the distal and proximal third regions of the radius. In the distal region of the right thoracic limb, hydroxyapatite with alendronate was used. In the distal region of the left thoracic limb, hydroxyapatite with collagen was used. Any biomaterial was used in proximal part of the limb. There was a retard in bony flaws consolidation in the spayed bitches. Hydroxyapatite with alendronate showed better result, since the place it was implanted considerably increased the bony formation. Both biomaterials presented biocompatibility, verified by the absence of inflammatory reaction or other undesirable reaction.

  4. PHAEOHYPHOMYCOSIS: CUTANEOUS, SUBCUTANEOUS, NASOPHARYNGEAL LESIONS

    Directory of Open Access Journals (Sweden)

    M. Rasoolinejad

    1999-06-01

    Full Text Available Phaeohyphomycosis is an amalgam of clinical diseases caused by a wide variety of dematiaceous fungi. We are reporting on a 16 year-old patient from Amol with subcutaneous cervical nodes and nasopharyngeal lesions of phaeohypho"nmycosis that were confirmed by pathological examination, direct smear, and culture. After treatment with an oral triazole (Itraconazole for 4 months, all nodes and lesions disappeared and treatment was stopped A new lesion appeared on his chest wall 8 months, therapy with itraconazole was restarted and commuted for a long time.

  5. Differential diagnosis of sacral lesions

    International Nuclear Information System (INIS)

    The authors reviewed the teaching files of Temple University Hospital and Children's Hospital of Philadelphia and selected the best representative cases of various lesions of the sacrum. They selected the following lesions: metastasis, chondrosarcoma, chrodoma, plasmacytoma, giant cell tumor, osteogenic sarcoma, Ewing sarcoma, neuroblastoma, neurofibrosarcoma, hemangiopericytoma, osteoblastoma, ossifying fibroma, eosinophilic granuloma, aneurysmal bone cyst, sacrococcygeal teratoma, anterior meningocele, endodermal sinus tumor, and stress fracture. The authors illustrate, for each lesion, the likely age range, sights of predilection, likelihood of occurrence in the sacrum, and radiographic findings helpful in limiting the differential diagnosis. They demonstrate the value of bone scintigraphy in detecting, and CT in confirming, stress fractures of the sacrum

  6. Bony regeneration effect of electron-beam irradiated hydroxyapatite and tricalcium phosphate mixtures with 7 to 3 ratio in the caravel defect model of rat

    International Nuclear Information System (INIS)

    The aim of this study is to evaluate the effect and potential of electron beam irradiation treatment to the new bone formation in the rat calvarial bony defects by using of 7 to 3 ratios of hydroxyapatite and tricalcium phosphate mixed with type I collagen. We used 1.0 MeV linear accelerator and 2.0 MeV superconductive linear accelerator with different irradiation dose, such as 1, 30, 60 kGy. And 10.0 MeV high frequency superconductive linear accelerator was also used. In six different experimental groups, the defect of every three rate was filled with E-beam irradiated bony mixtures, which different energy and dose, and that of rats without E-beam irradiated bony mixtures can be compared with out previous results. The other three rats were used as sham group. Rats were sacrificed after 4, 8, and 16 weeks, and grafted healing specimens were studied by clinical and radiographic findings, histomorphologic staining with hematoxylin and eosin. The large particular size of HLA was changed to small particles after E-beam irradiation, to which small particle of TEPC was engaged to small sexed HLA with organic collagen components in Seam findings. Abundant endothelial cells with preciosity were found around inner portions of grafted healing bone and many couplings of osteoblast with osteoclast in Tem findings were found in every experimental groups

  7. Effect of exercise and environmental terrain on development of the digital cushion and bony structures of the bovine foot.

    Science.gov (United States)

    Gard, Julie A; Taylor, Debra R; Wilhite, Dewey R; Rodning, Soren P; Schnuelle, Megan L; Sanders, Richard K; Beyers, Ronald J; Edmondson, Misty A; DeGraves, Fred J; van Santen, Edzard

    2015-03-01

    OBJECTIVE To determine whether exercise on alternative terrain affects the development of the digital cushion and bony structures of the bovine foot. ANIMALS 20 weaned bull calves. PROCEDURES Two-month-old calves were randomly allocated to an exercise or control group. For 4 months, the control group was maintained in grass paddocks, and the exercise group was maintained in a 0.8-km lane with a mixed terrain of dirt, stones (0.32- to 0.95-cm pea gravel and 5-cm crusher run), and grass. Water and food for the exercise group were located at opposite ends of the lane; calves were fed twice daily, which ensured they walked 3.2 km/d. Pedometers were applied to all calves to measure distance traveled. All calves were slaughtered at 6 months of age. The right forefeet and hind feet were harvested for MRI and CT evaluation. RESULTS Control calves walked a mean of 1.1 km daily, whereas the exercised calves walked a mean of 3.2 km daily. Mean digital cushion volume and surface area were 25,335 mm(3) and 15,647 mm(2), respectively, for the exercised calves and 17,026 mm(3) and 12,745 mm(2), respectively, for the control calves. When weight was controlled, mean digital cushion volume and surface area for the exercise group were increased by 37.10% and 18.25%, respectively, from those for the control group. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that exercise on alternative terrain increased the volume and surface area of the digital cushion of the feet of dairy calves, which should make them less susceptible to lameness. PMID:25710761

  8. Traumatic lesions of pulmonary parenchyma

    International Nuclear Information System (INIS)

    Five cases of post-traumatic pulmonary lesions (contusion, laceration and hematoma) are presented. The pathophysiology, radiological aspects and differential diagnosis are reviewed. The benign evolution showing the absorption in short time, without medical interference is emphasized. (Author)

  9. Post-radiotherapeutic heart lesions

    International Nuclear Information System (INIS)

    Heart structures have traditionally been considered radioresistant. In fact all tissues subjected to radiotherapy can develop lesions. Possible damage includes: - pericardiac fibrosis, the commonest and best individualized, associated with a constriction this leads to a stoppage pattern usually occurring late, around the 18th month. Its frequency depends directly on the total radiation dose; - fibrous myocarditis by direct damage to the heart muscle; - stenosis type lesions of the large coronary trunks; - in exceptional cases lesions of the aorta: hyperplastic degenerescence of the intima and adventitia or of the aortic sigmoid valvules and the mitral valves. Three observations are reported, concerning a coronary, a pericardiac and a coronary, myocardiac and pericardiac lesion. Following this account the irradiation techniques and main experimental data are reviewed and the prophylactic and therapeutic consequences to be derived from our observations and those of the literature are examined

  10. Thorotrast-associated gliosarcoma. Including comments on thorotrast use and review of sequelae with particular reference to lesions of the central nervous system.

    Science.gov (United States)

    Wargotz, E S; Sidawy, M K; Jannotta, F S

    1988-07-01

    The occurrence of a glioblastoma with sarcoma, a gliosarcoma, in the left frontal-temporal area of a 49-year-old woman with a history of Thorotrast exposure, is described. Thorotrast-laden histiocytes and free Thorotrast material were found in both components of the tumor. An overlying, adherent dural cranial lesion was found to contain massive deposits of Thorotrast embedded in a dense fibrotic and sclerotic stroma with focal calcification. These features are typical of "Thorotrastoma." Thorotrast stains greenish-brown with hematoxylin and eosin and appears as refractile granular particles of relatively uniform size either within histiocytes or as free material. The radioactivity of the deposits was confirmed through the use of a scintillation counter, and 232 thorium was definitively identified though the use of scanning electron microscopy with energy-dispersive X-ray analysis. Immunohistochemical studies of the tumor demonstrated glial fibrillary acid protein (GFAP) immunoreactivity in areas of glioma and focal vimentin and actin immunoreactivity in areas of sarcoma. Thorotrast-associated lesions of the central nervous system (CNS) are infrequently reported, and a Thorotrast-associated gliosarcoma has not yet been reported. The use of Thorotrast, its radiobiology, and sequelae are reviewed with particular emphasis on lesions occurring in the CNS. PMID:3289727

  11. Oral Lesions and Lymphoproliferative Disorders

    OpenAIRE

    Biasotto, M.; Tirelli, G.; Castellarin, P.; Di Lenarda, R.; Pozzato, G.

    2010-01-01

    Lymphoproliferative disorders are heterogeneous malignancy characterized by the expansion of a lymphoid clone more or less differentiated. At the level of the oral cavity, the lymphoproliferative disorder can occur in various ways, most commonly as lymphoid lesions with extranodal externalization, but sometimes, oral lesions may represent a localization of a disease spread. With regard to the primary localizations of lymphoproliferative disorders, a careful examination of the head and neck, o...

  12. MRI atlas of MS lesions

    Energy Technology Data Exchange (ETDEWEB)

    Sahraian, Mohammad Ali [Tehran Univ. of Medical Sciences Sina Hospital (Iran). Dept. of Neurology; Radue, Ernst-Wilhelm [Univ. Hospital Basel (Switzerland). Dept. of Neuroradiology

    2008-07-01

    MRI has become the main paraclinical test in the diagnosis and management of multiple sclerosis. We have demonstrated more than 400 pictures of different typical and atypical MS lesions in this atlas. Each image has a teaching point. New diagnostic criteria and differential diagnosis are discussed and the book is supported by a teaching DVD where the reader can see MS lesions in different slices and sequences. (orig.)

  13. [Cystic lesions of the pancreas].

    Science.gov (United States)

    Buerke, B; Schülke, C

    2015-02-01

    Due to the widespread use of computed tomography (CT) and magnetic resonance imaging (MRI) of the abdomen, the incidence of cystic pancreatic lesions as an incidental finding in asymptomatic patients is increasing; however, most of these lesions are less than 2 cm in size at the time of diagnosis making a correct classification difficult. A more differentiated understanding of the pathophysiology of these lesions has been developed during recent years. Technical improvements in imaging techniques have resulted in an increase in image resolution and has enabled radiologists to differentiate between intraductal papillary mucinous neoplasms (IPMN), serous cystic neoplasms (SCN) and mucinous cystic neoplasms (MCN). A correct classification, including the differentiation from malignant pancreatic tumors, can only be achieved by combining the knowledge of lesion pathophysiology and basic epidemiological data, such as age and sex distribution with modern imaging techniques. In conjunction with the correct diagnosis, the radiologist has to decide on the further management of the newly found lesion. This differs greatly depending on the biological behavior, especially the potential for malignant transformation, e.g. in main duct IPMN. This review gives an overview of the different cystic pancreatic lesions, their underlying pathophysiology and imaging characteristics along with recommendations for the further clinical management. PMID:25646005

  14. Hearing disorders in brainstem lesions.

    Science.gov (United States)

    Celesia, Gastone G

    2015-01-01

    Auditory processing can be disrupted by brainstem lesions. It is estimated that approximately 57% of brainstem lesions are associated with auditory disorders. However diseases of the brainstem usually involve many structures, producing a plethora of other neurologic deficits, often relegating "auditory symptoms in the background." Lesions below or within the cochlear nuclei result in ipsilateral auditory-processing abnormalities detected in routine testing; disorders rostral to the cochlear nuclei may result in bilateral abnormalities or may be silent. Lesions in the superior olivary complex and trapezoid body show a mixture of ipsilateral, contralateral, and bilateral abnormalities, whereas lesions of the lateral lemniscus, inferior colliculus, and medial geniculate body do not affect peripheral auditory processing and result in predominantly subtle contralateral abnormalities that may be missed by routine auditory testing. In these cases psychophysical methods developed for the evaluation of central auditory function should be employed (e.g., dichotic listening, interaural time perception, sound localization). The extensive connections of the auditory brainstem nuclei not only are responsible for binaural interaction but also assure redundancy in the system. This redundancy may explain why small brainstem lesions are sometimes clinically silent. Any disorder of the brainstem (e.g., neoplasms, vascular disorders, infections, trauma, demyelinating disorders, neurodegenerative diseases, malformations) that involves the auditory pathways and/or centers may produce hearing abnormalities. PMID:25726288

  15. Pineal lesions: a multidisciplinary challenge.

    Science.gov (United States)

    Westphal, Manfred; Emami, Pedram

    2015-01-01

    The pineal region is a complex anatomical compartment, harbouring the pineal gland surrounded by the quadrigeminal plate and the confluents of the internal cerebral veins to form the vein of Galen. The complexity of lesions in that region, however, goes far beyond the pineal parenchyma proper. Originating in the pineal gland, there are not only benign cysts but also numerous different tumour types. In addition, lesions such as tectal gliomas, tentorial meningiomas and choroid plexus papillomas arise from the surrounding structures, occupying that regions. Furthermore, the area has an affinity for metastatic lesions. Vascular lesions complete the spectrum mainly as small tectal arteriovenous malformations or cavernous haemangiomas.Taken together, there is a wide spectrum of lesions, many unique to that region, which call for a multidisciplinary approach. The limited access and anatomical complexity have generated a spectrum of anatomical approaches and raised the interest for neuroendoscopic approaches. Equally complex is the spectrum of treatment modalities such as microsurgery as the main option but stereotactic radiosurgery as an alternative or adjuvant to surgery for selected cases, radiation as for germinoma (see below) and or combinatorial chemotherapy, which may need to precede any other ablative technique as constituents.In this context, we review the current literature and our own series to obtain a snapshot sentiment of how to approach pineal lesions, how to interrelate alternative/competing concepts and review the recent technological advances. PMID:25411146

  16. Charakterystyka grzybów izolowanych z ?o??dka u chorych z wrzodami oraz z przewlek?ym zapaleniem b?ony ?luzowej

    Directory of Open Access Journals (Sweden)

    Alicja Budak

    2002-03-01

    Full Text Available Wst?p: Wyst?powanie kolonizacji grzybiczej wrzodów ?o??dka dotyczy 30-50% populacji chorych z endoskopowo rozpoznanym wrzodem ?o??dka. Badania potwierdzi?y, ?e kolonizacja grzybicza b?ony ?luzowej ?o??dka wp?ywa na proces gojenia wrzodu ?o??dka. Cel pracy: Celem przeprowadzonych bada? by?a: 1 ocena wyst?powania grzybów w materia?ach klinicznych pobranych z ?o??dka od chorych z wrzodem ?o??dka oraz przewlek?ym zapaleniem b?ony ?luzowej ?o??dka, 2 okre?lenie aktywno?ci proteolitycznej izolowanych szczepów grzybów - jednego z czynników patogenno?ci Candida spp. Materia? i metody: Badaniem mitologicznym obj?to 29 chorych z wrzodem ?o??dka oraz 60 z przewlek?ym zapaleniem b?ony ?luzowej ?o??dka. Zbadano 261 próbek pobranych podczas badania endoskopowego. St??enie grzybów w materia?ach klinicznych (CFU/ml okre?lono na podstawie badania ilo?ciowego. Identyfikacj? grzybów przeprowadzono, stosuj?c: pod?o?e Albicans ID 2 oraz testy ID 32C odczytywane w systemie ATB (bioMerieux. Do okre?lenia aktywno?ci proteolitycznej szczepów Candida zastosowano metod? spektrofotometryczn?. Pomiar absorbancji supernatantów badanych szczepów odczytywano w spektrofotometrze przy d?ugo?ci fali 380 nm. Wyniki: U 20,7% chorych z wrzodem ?o??dka oraz 5% z przewlek?ym zapaleniem b?ony ?luzowej ?o??dka stwierdzono klinicznie istotne st??enie grzybów, odpowiadaj?ce >105 CFU/ml. W badaniu mikologicznym 85 próbek pobranych od chorych z wrzodem ?o??dka wyhodowano grzyby z gatunków: C. glabrata (23%, C. albicans (21,9%, C. kefyr (2,3%, C. krusei (1.1%. U osób z przewlek?ym zapaleniem b?ony ?luzowej ?o??dka C. glabrata izolowano tylko w 2,8%, natomiast C. albicans w 15.7%. Szczepy charakteryzowa?y si? ró?n? aktywno?ci? proteolityczn?. Szczepy C. glabrata wykaza?y silniejsze w?a?ciwo?ci proteolityczne w porównaniu do C. albicans. Wnioski: Wyniki uzyskane z przeprowadzonych bada? mog? by? wykorzystane w epidemiologii oraz terapii zaka?e? grzybiczych.

  17. Multiple sclerosis masquerading as a mass lesion

    International Nuclear Information System (INIS)

    Six patients presenting with new neurological deficits underwent magnetic resonance imaging (MRI) that displayed mass lesions leading to diagnoses of tumor or abscess. Biopsy revealed demyelinating lesions. (orig.)

  18. Multiple sclerosis masquerading as a mass lesion

    Energy Technology Data Exchange (ETDEWEB)

    Giang, D.W. (Dept. of Neurology, Rochester Univ. Medical Center, NY (United States)); Poduri, K.R.; Friedman, P.A. (Dept. of Orthopedics, Rochester Univ. Medical Center, NY (United States)); Eskin, T.A. (Dept. of Pathology and Laboratory Medicine, Univ. of Florida Coll. of Medicine, Gainesville, FL (United States)); Ketonen, L.M. (Dept. of Radiology, Rochester Univ. Medical Center, NY (United States)); Wang, D.D. (Dept. of Neurology, Rochester Univ. Medical Center, NY (United States) Dept. of Pediatrics, Rochester Univ. Medical Center, NY (United States)); Herndon, R.M. (Dept. of Neurology, Good Samaritan Hospital, Portland, OR (United States))

    1992-04-01

    Six patients presenting with new neurological deficits underwent magnetic resonance imaging (MRI) that displayed mass lesions leading to diagnoses of tumor or abscess. Biopsy revealed demyelinating lesions. (orig.).

  19. L’art du vitrail en France au temps de la reconstruction et de la croissance. Note sur les fonds Hébert-Stevens - Bony conservés aux Archives nationales du monde du travail (Fonds n° 2002 001

    Directory of Open Access Journals (Sweden)

    Christian Hottin

    2009-11-01

    Full Text Available Cet article a pour objet de présenter brièvement le fonds de l’atelier Hébert-Stevens - Bony, entré aux Archives nationales (Archives nationales du monde du travail, Roubaix en 2002

  20. Lesiones Pigmentadas: Valoración Dermatoscópica / Pigmented lesions: Dermatoscopic evaluation

    Scientific Electronic Library Online (English)

    José Juan, Carbayo García.

    2011-06-01

    Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Presentamos el caso de una mujer de 73 años de edad que consulta por la presencia de varias lesiones maculopapulares de color marrón oscuro en región frontal siguiendo el nacimiento del pelo, de crecimiento y aparición progresiva, de varios meses de evolución. El diagnóstico a simple vista es dudoso [...] , haciéndonos pensar en queratosis seborreica, nevus atípico, melanoma o carcinoma basocelular. La dermatoscopia es una técnica de interés creciente para todos los médicos, posee una utilidad demostrada en el estudio de los tumores cutáneos, especialmente los pigmentados, y facilita el diagnóstico diferencial y la mejora de la precisión diagnóstica. Mediante este examen, las lesiones presentan estructuras características de carcinoma basocelular. Abstract in english We present the case of a 73 year old woman, who came to the consultancy due to several dark-brown maculopapular lesions on her forehead, all along the hairline. The lesions exhibited progressive growth and appeared to be of several months of evolution. At first glance diagnosis was unclear and led u [...] s to consider seborrhoeic keratosis, atypical nevus, melanoma or basal cell carcinoma. Dermatoscopy is a technique of increasing interest for the medical community since it has been demonstrated to be useful in the study of cutaneous tumours, specially pigmented ones. It facilitates differential diagnosis and improves diagnostic precision. Using this technique we determined that the lesions had the typical structures of basal cell carcinoma.

  1. Diffuse bony involvement in disseminated BCG disease in a patient with possible severe combined immune deficiency (SCID)

    OpenAIRE

    Khan, Nausheen; Werke, Irma; Ismail, Farzanah

    2010-01-01

    BCG (bacille Calmette-Guérin) vaccination is carried out worldwide to prevent tuberculosis. It is considered to be very effective and has an excellent safety profile, but complications do occur. These may range from erythema and abscess at the site of inoculation to extensive disseminated disease including regional and distant lymphadenopathy, lymphadenitis, musculoskeletal lesions and non-fatal and fatal disseminated infections, depending upon the immune status of the patient. Osteomyelitis...

  2. Reliability of Determination of Bony Landmarks of the Distal Femur on MR Images and MRI-Based 3D Models

    Directory of Open Access Journals (Sweden)

    F. Esfandiarpour

    2009-12-01

    Full Text Available Background/Objective: Consistent determination of the anatomical landmarks on image or image-based three dimensional (3D models is a basic requirement for reliable analysis of the human joint kinematics using imaging techniques. We examined the intra- and inter-observer reliability of determination of the medial and lateral epicondyle landmarks on 2D MR images and 3D MRI-based models of the knee. "n"n Materials and Methods: Sixteen coronal plane MRI recordings were taken from 18 healthy knees using a knee coil with T2-weighted fast spin-echo sequence and 512×512 pixel size. They were then processed by the Mimics software to provide the coronal and axial plane views and to create a 3D image-based model of the femur. Each image was reviewed twice, at least one-day apart. The interclass correlation coefficient, standard error of measurement, and coefficient of variation were calculated to assess the intra- and inter-observer reliability of the landmark determination by six experienced radiologists. A mixed model analysis of variance (ANOVA with two days of observation as the within-subject factor, and observers (six radiologists and methods (2D vs. 3D as between-subject factors were used to test the effect of observer, two days of observation and method of evaluation on landmark determination. Results: The results indicated that the interclass correlation coefficients for the intra-observer and inter-observer determination of landmarks on images and image-based 3D models were above 0.97. The standard error of measurement ranged between 0.41 and 0.78 mm for x; 1.35 and 3.43 mm for y; and 1.03 and 4.71 mm for z coordinates. Furthermore, the results showed no significant difference for within and between-subject comparisons of each coordinate of the lateral epicondyle as well as x and z coordinates of the medial epicondyle. For the y coordinate of the medial epicondyle, the p value of within-subject comparison was borderlinely significant (p=0.049. Conclusion: It was concluded that the intra- and inter-observer reliability of the bony landmark determination on both image and image-based 3D models were excellent.    

  3. 'Tripod' ossiculoplasty in incudal lesions.

    Science.gov (United States)

    Sadé, J; Kremer, S; Luntz, M

    1989-05-01

    A method of ossiculoplasty, in cases where the long process of the incus is eroded, is described. The defect created by the erosion of the incus is bridged by an autogenic or allogenic bone graft that leans on the stapes, the remaining part of the incus, and the side of the malleus. These three contact points allow for stability of the bony graft and account for the name tripod. The method was applied in 30 ears and was successful in all but three cases. All the rest (ie, 27 ears) achieved an average gain of 24.8 dB, leaving an average air-bone gap of 11.1 dB. The postoperative air-bone gap was 20 dB or less in all 27 ears that were successfully operated on; and in 21 of them (77.8%), it was no more than 10 dB. The average period of follow-up was 23.8 months. Operative success depended on both the technique chosen and the favorable selection of cases. PMID:2650715

  4. Focal splenic lesions: US findings.

    Science.gov (United States)

    Caremani, M; Occhini, U; Caremani, A; Tacconi, D; Lapini, L; Accorsi, A; Mazzarelli, C

    2013-01-01

    Ultrasound (US) imaging of the spleen was considered of little use in the past and was performed only to distinguish between cystic and solid lesions. However, in the last decade due to experience acquired and the introduction of second-generation contrast agents, this technique has been re-evaluated as contrast-enhanced US (CEUS) allows detection and characterization of most focal lesions of the spleen with a high sensitivity and a good specificity. Gray-scale US presents a low specificity in splenic infarctions with a high rate of false negative cases, whereas specificity reaches 100 %, if the examination is performed using US contrast agents. Gray-scale US can provide a correct diagnosis in simple cysts, whereas CEUS is useful when cystic lymphangioma is suspected. In the study of splenic lesions, the most important problem is to differentiate between angioma, hamartoma, lymphoma, and metastasis. CEUS reaches a good specificity in the differentiation of benign from malignant splenic lesions, as hypo-enhancement in the parenchymal phase is predictive of malignancy in 87 % of cases. In conclusion, Gray-scale US and particularly CEUS are at present widely indicated in the study of focal splenic lesions. PMID:24294345

  5. The radiology in the solitary bone lesions

    International Nuclear Information System (INIS)

    Three methods of radiologic analysis of the solitary bone lesions are reviewed. 1. Radiological analysis of the lesions with the objective to suppose the histologic type; 2. To appreciate the velocity of growth and aggressiveness of the lesions. 3. To appreciate the biological behaviour of the bone lesions, making the diagnosis necessary for the treatment. (M.A.C.)

  6. Lesiones focales hepáticas en niños / Focal liver lesions in children

    Scientific Electronic Library Online (English)

    Adalis, Rossell; Dianora, Navarro; Karolina, López; Enicar, Perla; Betzabeth, Quintana; Credy, Figueredo; Andrea, Nogales; Katiuska, Belandria.

    2013-06-01

    Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Introducción: Las lesiones focales del hígado comprenden un grupo heterogéneo de entidades como tumores benignos y malignos, sólidos o quistes, vasculares, masas inflamatorias y metástasis, entre otras. Objetivo: reportar lesiones focales hepáticas en niños, características clínicas, estudios por im [...] ágenes y conducta terapéutica. Pacientes y Métodos: Estudio descriptivo, retrospectivo, basado en la revisión de 16 historias clínicas de niños con lesiones focales hepáticas en el periodo comprendido entre enero 2007 a enero 2012. Se excluyeron los abscesos hepáticos. Resultados: El 68,75%11 eran del sexo masculino y 31,25%5 del sexo femenino; con edad promedio de 9,5 años (rango: 10 días - 14 años). Las lesiones focales benignas fueron: hemangioma 4/16 (25%), hematoma hepático 4/16 (25%), quiste hepático 3/16 (18,75%), hiperplasia nodular focal 1/16 (6,25%) adenoma 1/16 (6,25%) y las malignas: hepatocarcinoma 2/16 (12,50%) y hepatoblastoma 1/16 (6,25%). La mayoría de los pacientes (56,25%) se encontraban asintomáticos, 3/16 (18,75%) presentaron dolor abdominal, 3/16 (18,75%) masa palpable y 2/16 (12,5%) ictericia. La lesión fue identificada por ultrasonido abdominal en todos los pacientes y sólo el 56,25% (9/16) ameritaron tomografía con contraste. Al 43,75% (7/16) se les realizó marcadores tumorales y de estos el 42,85% (3/7) reportaron neoplasias. El funcionalismo hepático reportó normal en el 75% de los casos. Conclusión: El ultrasonido abdominal es el método de elección para el diagnóstico y seguimiento de las lesiones focales hepáticas, mientras el origen de las mismas, guía la conducta terapéutica. Abstract in english Introduction: focal liver lesions comprise a heterogeneous group of entities such as benign and malignant, solid or cysts, vascular, inflammatory masses and metastasis among others. Objective: To report focal liver lesions in children, clinical features, imaging and therapeutic behavior. Patients an [...] d Methods: A descriptive, retrospective study based on a review of 16 case histories of children with focal liver lesions in the period from January 2007 to January 2012. Liver abscesses were excluded. Results: 68.75%11 were male and 31.25%5 females, mean age 9.5 years (range: 10 days - 14 years). Focal lesions were benign: Hemangioma 4/16 (25%), liver hematoma 4/16 (25%), hepatic cyst 3/16 (18.75%), nodular focal hyperplasia 1/16 (6.25%) and adenomas 1/16 (6.25%) and malignant: Hepatocellular carcinoma 2/16 (12.50%) and hepatoblastoma 1/16 (6.25%). Most patients (56.25%) were asymptomatic, 3/16 (18.75%) had abdominal pain, 3/16 (18.75%) and palpable mass 2/16 (12.5%) jaundice. The lesion was identified by abdominal ultrasound in all patients and only 56.25% (9/16) needed tomography with contrast. To 43.75% (7/16) underwent tumor markers and of these 42.85% (3/7) reported neoplasm. Normal hepatic function reported in 75% of cases. Conclusion: An abdominal ultrasound is the method of choice for the diagnosis and management of focal liver lesions, while the origin of them, guide therapeutic conduct.

  7. Ultrasonography of chest wall lesion

    Energy Technology Data Exchange (ETDEWEB)

    Park, Cheol Min; Kim, C. H.; Cha, I. H.; Chung, K. B.; Ser, W. H.; Choi, Y. H. [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1989-12-15

    Thirty-one patients with chest wall diseases were studied with ultrasound to evaluate its role in chest wall lesions. There were eight infectious conditions, 9 benign tumors, 11 malignant lesions and 3 miscellaneous cases. Diffuse chest wall thickening with heterogeneous echogenicity and obliteration of subcutaneous fat layer are findings of acute infection. In cases of tuberculous smpyema necessitates, pleural abnormality extended to the chest wall through intercostal space. Benign tumors were well demarcated, except in 4 cases of lipoma/lipomatosis. Malignant lesions showed irregular soft tissue masses, bone destruction, pleural effusion and subcutaneous invasion. Multiple enlarged lymph nodes were also shown. Ultrasound can demonstrate te internal structure, extent, depth and associated findings such as pleural effusion, bone destruction and peripheral lung involvement. Ultrasound is not only safe, non-invasive and an effective diagnostic imaging modality for chest wall disease, but can also guide aspiration or biopsy for pathologic diagnosis

  8. Ultrasonography of chest wall lesion

    International Nuclear Information System (INIS)

    Thirty-one patients with chest wall diseases were studied with ultrasound to evaluate its role in chest wall lesions. There were eight infectious conditions, 9 benign tumors, 11 malignant lesions and 3 miscellaneous cases. Diffuse chest wall thickening with heterogeneous echogenicity and obliteration of subcutaneous fat layer are findings of acute infection. In cases of tuberculous smpyema necessitates, pleural abnormality extended to the chest wall through intercostal space. Benign tumors were well demarcated, except in 4 cases of lipoma/lipomatosis. Malignant lesions showed irregular soft tissue masses, bone destruction, pleural effusion and subcutaneous invasion. Multiple enlarged lymph nodes were also shown. Ultrasound can demonstrate te internal structure, extent, depth and associated findings such as pleural effusion, bone destruction and peripheral lung involvement. Ultrasound is not only safe, non-invasive and an effective diagnostic imaging modality for chest wall disease, but can also guide aspiration or biopsy for pathologic diagnosis

  9. Round pulmonary lesions in children

    International Nuclear Information System (INIS)

    Full text: Pediatric radiology means application of diagnostic methods in the prevention, diagnosis, treatment and follow-up of the diseases during the period of infancy and childhood. Interpretation of the child's chest radiograph is probably the most difficult plain film problem presented to the radiologists with a predominantly adult practise. Radiological findings as well as the pathological entities are often different in children then in adults and this could lead to incorrect interpretation with determination of inappropriate management and unnecessary additional investigations. The aim of the study is radiological assesment of the round pulmonary lesions in the childhood,using the classical and modern 'imaging' methods. What is round lesions? The symptom round lesions included pulmonary pathological lesions, which in radiological examination in one projection are giving one or more shadows with a round(oval) shape and a diameter greater than 1 cm. For that purpose and for appropriate statistical analysis, the total pathology is systematized into three groups: inflammations, parasite diseases and tumors of mediastinum. Conventional radiography remains the basic examination and most frequently used method in the evaluation of all thoracic abnormalities. The main task of the radiologist is to suggest further 'imaging' procedure,having into account the advantages and shortcomings of each method separately. From the general statistical analysis it is clear that mos statistical analysis it is clear that most of the patients with round pulmonary lesions in the childhood are boys and having parasite etiology of the shadow. They are followed by inflammatory lesions with non-specific and specific etiology and tumors in the mediastinum.

  10. [The treatment of decubitus lesions].

    Science.gov (United States)

    Fugazza, G; Moroni, S; Bona, F

    1995-01-01

    The authors present a plan for pharmacological treatment of pressure sores in patients affected by neurological pathologies: cerebrovascular accidents, head injuries, spinal cord injuries. This plan is easily applicable to all pressure sores included between first and third degree of the Reuler and Cooney classification. Authors identified some drugs specifically usefull in different cutaneous lesion degrees. Skin lesions and employed medicines are described as follows: Erythema: semi occlusive bandage with porous adsorbing membrane. This dressing must be left in for five days at least. Excoriation: bactericidal or bacteriostatic medicines if it's situated in a non pressed area while the same dressing utilized for erythema if it's localized in a pressed area. Pressure sores: if there is local infection cleanse the wound from bacterial defilement using topic antibiotics apply compresses with vitamin C if the cutaneous lesion is larger than deeper, Cadexomero lodico if it's deeper than larger. Fistulas: wadding with tablets of collagen. Necrobiosis: complete or partial surgical removal of eschar preceded by the use of enzymatic drugs when eschar is firmly adherent to subcutaneous tissues. The first group collects 9 patients with stroke and head injury: 8 with sacral and 1 with heel pressure sores. First degree pressure sores heal within 45 days and third degree lesions within 160 days. The second group collects 10 spinal cord injury patients mostly with complete lesion among which: 7 sacral, 1 heel, 1 ischiatic and 1 malleolar lesions. First degree pressure sores heal within 30 days, third degree pressure sores heal within 200 days. Healing time are considered acceptable. Pressure sores recovery swiftness can be related to different factors such as pressure sores sterness, neurological pathology and arising of clinical complication (hyperthermia, infections, low serum albumin values, etc). PMID:8766788

  11. MRI of orbital lesions; Pseudotumor and its simulating lesions

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Yaeko; Nakasato, Tatsuhiko; Sone, Miyuki; Sasaki, Mari; Ehara, Shigeru; Tamakawa, Yoshiharu (Iwate Medical Coll., Morioka (Japan). School of Medicine); Itoh, Shiori; Konishi, Nobuhiro

    1994-03-01

    MR imaging is helpful for evaluation of the extent of the orbital lesion. Myositic pseudotumor and lymphoid hyperplasia tend to have intermediate signal intensity on T2-weighted images, may be of value in the differential diagnosis of myositic pseudotumor. (author).

  12. Dynamic MRI of orbital lesions

    International Nuclear Information System (INIS)

    Study of time intensity curves was performed for 15 orbital lesions. Inflammatory lesions (2 chronic dacryoadenitis, 1 chalazion, 1 inflammatory pseudotumor), 1 meningioma, and 4 pseudolymphoma showed rapid increase with run off. They showed peak formations within 2 minutes. Tumors except for meningioma (3 malignant lymphoma, 2 retinoblastoma, 1 pleomorphic adenoma of lacrimal gland) showed gradual increase without peak formation. No difference between benign and malignancy was detected. Dynamic MRI would be useful for differential diagnosis between pseudotumor and malignant lymphoma, that has been difficult for imaging diagnosis so far. (author)

  13. Dynamic MRI of orbital lesions

    Energy Technology Data Exchange (ETDEWEB)

    Sawada, Akihiro; Matsumoto, Hiroko (Kochi Medical School, Nangoku (Japan))

    1991-04-01

    Study of time intensity curves was performed for 15 orbital lesions. Inflammatory lesions (2 chronic dacryoadenitis, 1 chalazion, 1 inflammatory pseudotumor), 1 meningioma, and 4 pseudolymphoma showed rapid increase with run off. They showed peak formations within 2 minutes. Tumors except for meningioma (3 malignant lymphoma, 2 retinoblastoma, 1 pleomorphic adenoma of lacrimal gland) showed gradual increase without peak formation. No difference between benign and malignancy was detected. Dynamic MRI would be useful for differential diagnosis between pseudotumor and malignant lymphoma, that has been difficult for imaging diagnosis so far. (author).

  14. Nodular lesion in renal tuberculosis

    International Nuclear Information System (INIS)

    The authors have retrospectively studied the CT findings of renal tuberculosis in 27 cases (32 kidneys). As a characteristic CT finding, the nodular lesion was recognized in 20 kidneys (three low-density nodules, seven isodensity nodules, and 10 high-density nodules). In a case with a follow-up CT scan after 5 years, the low-density and isodensity nodules changed to high-density nodules with decreasing volume. The authors believe that the density differences in these nodular lesions reflect the process of resorption of water from the caseous necrotizing materials of tuberculosis

  15. Localized lesions in secondary syphillis

    International Nuclear Information System (INIS)

    The clinical manifestations of secondary syphilis are variable and can mimic many skin diseases, mostly being generalized and symmetrical in distribution. Localized lesions of secondary syphilis are rarely seen in dermatology clinics. We report an unusual presentation wherein a patient had localized lesions over face and soles only. There is a need for increased awareness on the part of physicians to recognize new patterns of syphilitic infection, together with a willingness to consider the diagnosis of syphilis in patients with unusual clinical features. (author)

  16. Focal splenic lesions: US findings

    OpenAIRE

    Caremani, M.; Occhini, U.; Caremani, A.; Tacconi, D.; Lapini, L.; Accorsi, A.; Mazzarelli, C.

    2013-01-01

    Ultrasound (US) imaging of the spleen was considered of little use in the past and was performed only to distinguish between cystic and solid lesions. However, in the last decade due to experience acquired and the introduction of second-generation contrast agents, this technique has been re-evaluated as contrast-enhanced US (CEUS) allows detection and characterization of most focal lesions of the spleen with a high sensitivity and a good specificity. Gray-scale US presents a low specificity i...

  17. Bony integration of titanium implants with a novel bioactive calcium titanate (Ca4Ti3O10) surface treatment in a rabbit model.

    Science.gov (United States)

    Haenle, Maximilian; Lindner, Tobias; Ellenrieder, Martin; Willfahrt, Manfred; Schell, Hanna; Mittelmeier, Wolfram; Bader, Rainer

    2012-10-01

    Nowadays total joint replacement is an indispensable component of modern medicine. The surfaces characteristics of cementless prostheses may be altered to achieve an accelerated and enduring bony integration. Classic surface coatings bear the risk of loosening or flaking from the implant body. This risk is excluded by the chemical conversion of the naturally existing TiO(2) surface layer into calcium titanate. The aim of this experimental animal study was to investigate the bony integration of implants with a new calcium titanate surface (Ca(4)Ti(3)O(10)) compared with a conventional standard Ti6Al4V surface. Cylindrical implants, made of titanium alloy (Ti6Al4V) were implanted in both lateral femoral condyles of New Zealand white rabbits. In each animal, an implant with and without surface treatment was inserted in a blinded manner. Animals were sacrificed after 4, 12, and 36 weeks, respectively. The axial pull-off forces were determined for 25 animals using a universal testing machine (Zwick Z010, Ulm, Germany). Furthermore, a histological analysis of the bony integration of the implants was performed in 12 specimens. In general, the pull-off forces for untreated and treated implants increased with longer survival times of the rabbits. No significant difference could be shown after 4 weeks between treated and untreated implants. After 12 weeks, the treated implants revealed a statistical significant higher pull-off force. After 36 weeks, the pull-off forces for treated and untreated implants aligned again. Titanium implants treated with calcium titanate, may offer an interesting and promising implant surface modification for endoprosthetic implants. They might lead to an accelerated osseointegration of total hip and knee replacements. PMID:22623353

  18. Use of enamel matrix protein derivative with minimally invasive surgical approach in intra-bony periodontal defects: clinical and patient-centered outcomes

    Scientific Electronic Library Online (English)

    Fernanda Vieira, Ribeiro; Francisco Humberto, Nociti Júnior; Enilson Antonio, Sallum; Antonio Wilson, Sallum; Márcio Zaffalon, Casati.

    2010-01-01

    Full Text Available O objetivo deste estudo foi avaliar os resultados clínicos e centrados no paciente após abordagem cirúrgica minimamente invasiva (CMI) associada à aplicação das proteínas derivadas da matriz do esmalte (PDE) no tratamento de defeitos infra-ósseos. Doze pacientes apresentando um sítio com profundidad [...] e de sondagem >5 mm e sangramento à sondagem , associado à evidência radiográfica de defeito infra-ósseo, foram tratados com CMI e aplicação das PDE. Os parâmetros clínicos foram avaliados imediatamente antes do procedimento e após 3 e 6 meses. A percepção de dor e desconforto do paciente durante o período trans-cirúrgico e ao longo da primeira semana de pós-operatório, bem como a satisfação estética 6 meses após o tratamento, foram avaliadas por meio de questionários. Os resultados mostraram que o uso da CMI associada à aplicação de PDE promoveu melhoras estatisticamente significantes nos parâmetros clínicos, mínima dor e desconforto e máxima satisfação estética aos pacientes. Dentro dos limites do estudo, foi demonstrado que a associação de CMI e PDE, no tratamento de defeitos infra-ósseos, é capaz de promover satisfatórios resultados clínicos e centrados no paciente. Abstract in english This case series evaluated the clinical performance and patient-centered outcomes after a minimally invasive surgical technique (MIST) associated with enamel matrix protein derivative (EMD), for the treatment of intra-bony defects. Twelve patients presenting teeth with probing depth >5 mm and bleedi [...] ng on probing associated with radiographic evidence of intra-bony defect were treated by MIST associated with EMD. Clinical parameters were measured at baseline, 3 and 6 months. Patient perception during the intraoperative period and during the first postoperative week was evaluated. The use of MIST with EDM promoted significant improvements in clinical parameters, minimal pain/discomfort and maximum esthetics satisfaction. Within of limits of the present study, it could be shown that MIST combined with EMD for the treatment of intra-bony defects promotes satisfactory clinical and patient-centered outcomes.

  19. Scales and dermal skeletal histology of an early bony fish Psarolepis romeri and their bearing on the evolution of rhombic scales and hard tissues.

    Science.gov (United States)

    Qu, Qingming; Zhu, Min; Wang, Wei

    2013-01-01

    Recent discoveries of early bony fishes from the Silurian and earliest Devonian of South China (e.g. Psarolepis, Achoania, Meemannia, Styloichthys and Guiyu) have been crucial in understanding the origin and early diversification of the osteichthyans (bony fishes and tetrapods). All these early fishes, except Guiyu, have their dermal skeletal surface punctured by relatively large pore openings. However, among these early fishes little is known about scale morphology and dermal skeletal histology. Here we report new data about the scales and dermal skeletal histology of Psarolepis romeri, a taxon with important implications for studying the phylogeny of early gnathostomes and early osteichthyans. Seven subtypes of rhombic scales with similar histological composition and surface sculpture are referred to Psarolepis romeri. They are generally thick and show a faint antero-dorsal process and a broad peg-and-socket structure. In contrast to previously reported rhombic scales of osteichthyans, these scales bear a neck between crown and base as in acanthodian scales. Histologically, the crown is composed of several generations of odontodes and an irregular canal system connecting cylindrical pore cavities. Younger odontodes are deposited on older ones both superpositionally and areally. The bony tissues forming the keel of the scale are shown to be lamellar bone with plywood-like structure, whereas the other parts of the base are composed of pseudo-lamellar bone with parallel collagen fibers. The unique tissue combination in the keel (i.e., extrinsic Sharpey's fibers orthogonal to the intrinsic orthogonal sets of collagen fibers) has rarely been reported in the keel of other rhombic scales. The new data provide insights into the early evolution of rhombic (ganoid and cosmoid) scales in osteichthyans, and add to our knowledge of hard tissues of early vertebrates. PMID:23585902

  20. Lesiones de cameron: experiencia clínica / Cameron lesions: clinical experience

    Scientific Electronic Library Online (English)

    Roberto J., Bernardo; Juan P., Portocarrero; Martín, Tagle.

    2012-04-01

    Full Text Available Es importante considerar a las lesiones de Cameron dentro del diagnóstico diferencial de causas de anemia por deficiencia de hierro secundarias a pérdidas gastrointestinales. Presentamos los datos demográficos, los hallazgos clínico-patológicos y el manejo terapéutico de pacientes con úlceras de Cam [...] eron evaluados en una clínica privada de Lima, Perú. Doce pacientes, nueve de ellos hombres, fueron incluidos en el reporte. La media de la edad al momento del diagnostico fue de 71 años (rango de edades 49-91 años). Cinco pacientes tuvieron anemia, uno de ellos catalogado como anemia severa. 91.7% de los pacientes presentaron hernias hiatales gigantes. Todos los pacientes con anemia tenían hiatos herniarios gigantes. Dos pacientes tuvieron pruebas positivas para infección por H. pylori. Dos pacientes refirieron crónico de anti-inflamatorios no esteroideos (AINES). Conclusiones: Las úlceras de Cameron son lesiones causantes de sangrado gastrointestinal crónico, y deben considerarse en el estudio de pacientes con anemia por déficit de hierro. Abstract in english Cameron lesions are becoming an increasingly important diagnosis in the evaluation of patients with iron deficiency anemia. We describe the demographic data, clinico-pathologic features and therapeutic outcome of a group of patients with Cameron lesions at a single private practice clinic in Lima, P [...] eru. Twelve patients (9 men) were included in the report Median age at diagnosis was 71 years (range 49-91). Five patients had anemia and one of them had severe anemia. 91.7% of our patients presented with large hiatal| hernias. There were 5 patients with anemia and large hernias. Two patients tested positive for H. pylori. Two patients reported chronic NSAIDs use. Conclusions: Cameron lesions are not an uncommon cause of chronic gastrointestinal bleeding and should be kept in mind in the study of patients with iron deficiency anemia.

  1. Imaging of extradural spinal lesions; Bildgebung extraduraler Raumforderungen

    Energy Technology Data Exchange (ETDEWEB)

    Ahlhelm, F.; Schulte-Altedorneburg, G.; Naumann, N.; Reith, W. (Universitaetsklinikum des Saarlandes, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Homburg/Saar); Nabhan, A. (Universitaetsklinikum des Saarlandes, Homburg/Saar, Klinik fuer Allgemeine und Spezielle Neurochirurgie)

    2006-12-15

    There is a wide variety of spinal extradural tumors. In addition to real neoplasms, degenerative diseases, congenital abnormalities and inflammatory disorders can be causes of extradural masses. Due to the bony boundary of the spinal canal, both benign as well as malignant masses can cause progressive neurological deficits including paraplegia. Most of the spinal tumors are benign (hemangioma of the vertebral body, degenerative diseases). In younger patients congenital abnormalities and primary tumors of the spine have to be considered, whereas in adults the list of differential diagnoses should include secondary malignancies such as metastases and lymphomas as well as metabolic disorders such as osteoporotic vertebral compression fracture and Paget's disease. Cross-sectional imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) of the spine often help to make a specific diagnosis of extradural spinal lesions and represent important tools for tumor staging and preoperative evaluation. (orig.) Das Spektrum der spinalen extraduralen Tumoren ist sehr gross. Neben echten Neoplasien koennen auch degenerative Veraenderungen und Anlagestoerungen sowie entzuendliche Veraenderungen Ursachen einer extraduralen Raumforderung sein. Aufgrund der knoechernen Begrenzung des Spinalkanals koennen neben Malignomen auch benigne Tumoren und degenerative spinale Veraenderungen zu progredienten neurologischen Ausfallsymptomen (einschliesslich Querschnittsymptomatik) fuehren. Die ueberwiegende Mehrzahl der extraduralen Raumforderungen der Wirbelsaeule ist benigne (Haemangiom des Wirbelkoerpers, degenerative Erkrankungen). Bei jungen Patienten sind Anlagestoerungen und primaere Wirbelsaeulentumoren zu beruecksichtigen, wogegen beim Erwachsenen an sekundaere Malignome, wie Metastasen und Lymphome sowie eine metabolische Erkrankung, wie die osteoporotische Wirbelkoerpersinterungsfraktur oder der Morbus Paget, differenzialdiagnostisch gedacht werden sollte. Schnittbilddiagnostische Verfahren, wie die Computertomographie und die Magnetresonanztomographie, der Wirbelsaeule ermoeglichen in vielen Faellen eine artdiagnostische Zuordnung von Wirbelsaeulenlaesionen und sind ein wichtiges Instrument fuer das Tumorstaging und die praeoperative Planung. (orig.)

  2. The added value of multislice SPECT/CT in patients with equivocal bony metastasis from carcinoma of the prostate

    International Nuclear Information System (INIS)

    The purpose of this study was to investigate the additional value of single photon emission computed tomography/computed tomography (SPECT/CT) over whole-body planar bone scintigraphy and SPECT in prostate cancer patients in terms of diagnostic confidence, inter-reviewer agreement and the possible impact on the clinical management. This was a retrospective review of 40 consecutive prostate cancer patients (mean age 71 years) who underwent 99mTc-methylene diphosphonate (MDP) whole-body planar bone scintigraphy, SPECT and SPECT/CT between April 2006 and April 2008. The images were evaluated by two independent reviewers; inter-reviewer agreement was evaluated using a weighted kappa score. Each focus of abnormal increased tracer uptake was recorded using a 4-point diagnostic confidence scale. Institutional Review Board approval was obtained. Fifty lesions on planar bone scintigraphy in the 40 patients were evaluated. On reporting the planar study and SPECT scans, reviewers rated 61% of lesions as equivocal. On reporting the SPECT/CT scans only 8% of lesions were rated as equivocal, 24% were rated as malignant and 68% as benign. Weighted kappa scores for inter-reviewer agreement were 0.43 for bone scintigraphy, 0.56 for SPECT and 0.87 for SPECT/CT. All were significant at p < 0.0001. Follow-up imaging confirmed the SPECT/CT diagnoses in 14 patients. The addition of SPECT/CT resulted in a significant reduction of equivocal reports; a definitive diagnosis was givel reports; a definitive diagnosis was given in the majority of the patients due to the improved diagnostic confidence compared to planar or SPECT imaging alone in prostate cancer patients with suspected bone metastases. (orig.)

  3. Imaging inflammatory acne: lesion detection and tracking

    Science.gov (United States)

    Cula, Gabriela O.; Bargo, Paulo R.; Kollias, Nikiforos

    2010-02-01

    It is known that effectiveness of acne treatment increases when the lesions are detected earlier, before they could progress into mature wound-like lesions, which lead to scarring and discoloration. However, little is known about the evolution of acne from early signs until after the lesion heals. In this work we computationally characterize the evolution of inflammatory acne lesions, based on analyzing cross-polarized images that document acne-prone facial skin over time. Taking skin images over time, and being able to follow skin features in these images present serious challenges, due to change in the appearance of skin, difficulty in repositioning the subject, involuntary movement such as breathing. A computational technique for automatic detection of lesions by separating the background normal skin from the acne lesions, based on fitting Gaussian distributions to the intensity histograms, is presented. In order to track and quantify the evolution of lesions, in terms of the degree of progress or regress, we designed a study to capture facial skin images from an acne-prone young individual, followed over the course of 3 different time points. Based on the behavior of the lesions between two consecutive time points, the automatically detected lesions are classified in four categories: new lesions, resolved lesions (i.e. lesions that disappear completely), lesions that are progressing, and lesions that are regressing (i.e. lesions in the process of healing). The classification our methods achieve correlates well with visual inspection of a trained human grader.

  4. Case report 495: Oesteochondroma-like femoral lesions due to chronic professional stress in a Swiss cheese-maker

    International Nuclear Information System (INIS)

    The case is presented of a 78-year-old man who was under treatment for carcinoma of the prostate with skeletal metastasis. As an incidental finding, clinically and radiologically, bony proturbances were observed to involve the right femoral shaft, reminescent of solitary cartilaginous exostoses. This was particularly true of the osseous overgrowth arising from the anterior aspect in the middle third of the right femur. A thick apposition of periosteal new bone was observed. However, a true cartilaginous cap was not present in either lesion excluding a solitary cartilagenous exostosis. A diagnosis of chronic stress was made, associated with the patient's occupation for 34 years as a cheese-maker, resulting in the bony alterations in the right femoral shaft. The history of lifting of cheeses with a weight of up to 120 kg from the shelf to the right thigh of the patient and from there to a table for washing, presumably had caused microfractures and subperiosteal hematomas on the surface of the femur. The mechanism of injury was discussed in detail and the subject of stress injuries incurred by such individuals as professional dancers was considered. The literature was reviewed. (orig.)

  5. Distance-to-Agreement Investigation of Tomotherapy's Bony Anatomy-Based Autoregistration and Planning Target Volume Contour-Based Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Steve, E-mail: ssuh@coh.org [Division of Radiation Oncology, City of Hope National Medical Center, Duarte, California (United States); Schultheiss, Timothy E. [Division of Radiation Oncology, City of Hope National Medical Center, Duarte, California (United States)

    2013-03-01

    Purpose: To compare Tomotherapy's megavoltage computed tomography bony anatomy autoregistration with the best achievable registration, assuming no deformation and perfect knowledge of planning target volume (PTV) location. Methods and Materials: Distance-to-agreement (DTA) of the PTV was determined by applying a rigid-body shift to the PTV region of interest of the prostate from its reference position, assuming no deformations. Planning target volume region of interest of the prostate was extracted from the patient archives. The reference position was set by the 6 degrees of freedom (dof)—x, y, z, roll, pitch, and yaw—optimization results from the previous study at this institution. The DTA and the compensating parameters were calculated by the shift of the PTV from the reference 6-dof to the 4-dof—x, y, z, and roll—optimization. In this study, the effectiveness of Tomotherapy's 4-dof bony anatomy–based autoregistration was compared with the idealized 4-dof PTV contour-based optimization. Results: The maximum DTA (maxDTA) of the bony anatomy-based autoregistration was 3.2 ± 1.9 mm, with the maximum value of 8.0 mm. The maxDTA of the contour-based optimization was 1.8 ± 1.3 mm, with the maximum value of 5.7 mm. Comparison of Pearson correlation of the compensating parameters between the 2 4-dof optimization algorithms shows that there is a small but statistically significant correlation in y and z (0.236 and 0.300, respectively), whereas there is very weak correlation in x and roll (0.062 and 0.025, respectively). Conclusions: We find that there is an average improvement of approximately 1 mm in terms of maxDTA on the PTV going from 4-dof bony anatomy-based autoregistration to the 4-dof contour-based optimization. Pearson correlation analysis of the 2 4-dof optimizations suggests that uncertainties due to deformation and inadequate resolution account for much of the compensating parameters, but pitch variation also makes a statistically significant contribution.

  6. Comparison of prostate set-up accuracy and margins with off-line bony anatomy corrections and online implanted fiducial-based corrections.

    Science.gov (United States)

    Greer, P B; Dahl, K; Ebert, M A; Wratten, C; White, M; Denham, J W

    2008-10-01

    The aim of the study was to determine prostate set-up accuracy and set-up margins with off-line bony anatomy-based imaging protocols, compared with online implanted fiducial marker-based imaging with daily corrections. Eleven patients were treated with implanted prostate fiducial markers and online set-up corrections. Pretreatment orthogonal electronic portal images were acquired to determine couch shifts and verification images were acquired during treatment to measure residual set-up error. The prostate set-up errors that would result from skin marker set-up, off-line bony anatomy-based protocols and online fiducial marker-based corrections were determined. Set-up margins were calculated for each set-up technique using the percentage of encompassed isocentres and a margin recipe. The prostate systematic set-up errors in the medial-lateral, superior-inferior and anterior-posterior directions for skin marker set-up were 2.2, 3.6 and 4.5 mm (1 standard deviation). For our bony anatomy-based off-line protocol the prostate systematic set-up errors were 1.6, 2.5 and 4.4 mm. For the online fiducial based set-up the results were 0.5, 1.4 and 1.4 mm. A prostate systematic error of 10.2 mm was uncorrected by the off-line bone protocol in one patient. Set-up margins calculated to encompass 98% of prostate set-up shifts were 11-14 mm with bone off-line set-up and 4-7 mm with online fiducial markers. Margins from the van Herk margin recipe were generally 1-2 mm smaller. Bony anatomy-based set-up protocols improve the group prostate set-up error compared with skin marks; however, large prostate systematic errors can remain undetected or systematic errors increased for individual patients. The margin required for set-up errors was found to be 10-15 mm unless implanted fiducial markers are available for treatment guidance. PMID:19032399

  7. Comparison of prostate set-up accuracy and margins with off-line bony anatomy corrections and online implanted fiducial-based corrections

    International Nuclear Information System (INIS)

    Full text: The aim of the study was to determine prostate set-up accuracy and set-up margins with off-line bony anatomy-based imaging protocols, compared with online implanted fiducial marker-based imaging with daily corrections. Eleven patients were treated with implanted prostate fiducial markers and online set-up corrections. Pretreatment orthogonal electronic portal images were acquired to determine couch shifts and verification images were acquired during treatment to measure residual set-up error. The prostate set-up errors that would result from skin marker set-up, off-line bony anatomy-based protocols and online fiducial marker-based corrections were determined. Set-up margins were calculated for each set-up technique using the percentage of encompassed isocentres land a margin recipe. The prostate systematic set-up errors in the medial-lateral, superior-inferior and anterior-I posterior directions for skin marker set-up were 2.2, 3.6 and 4.5 mm (1 standard deviation). For our bony anatomy-I based off-line protocol the prostate systematic set-up errors were 1.6, 2.5 and 4.4 mm. For the online fiducial based set-up the results were 0.5, 1.4 and 1.4 mm. A prostate systematic error of 10.2 mm was uncorrected by the off-line bone protocol in one patient. Set-up margins calculated to encompass 98% of prostate set-up shifts were 111-14 mm with bone off-line set-up and 4-7 mm with online fiducial markers. Margins from the van Herk margin I recipe were generally 1-2 m Herk margin I recipe were generally 1-2 mm smaller. Bony anatomy-based set-up protocols improve the group prostate set-up error compared with skin marks; however, large prostate systematic errors can remain undetected or systematic (errors increased for individual patients. The margin required for set-up errors was found to be 10-15 mm unless I implanted fiducial markers are available for treatment guidance.

  8. Stereotactic lesioning for mental illness

    International Nuclear Information System (INIS)

    The authors report stereotactically created lesioning by radiofrequency or Cyberknife radiosurgery for patients with mental illness. Since 1993, thirty-eight patients have undergone stereotactic psychosurgery for medically intractable mental illnesses. Two patients had aggressive behavior. Twenty-five patients suffered from Obsessive-Compulsive Disorder (OCD) and ten patients had depression. Another patient suffered from atypical psychosis. Bilateral amygdalotomy and subcaudate tractotomy were done for aggressive behavior. Limbic leucotomy or anterior cingulotomy was done for CCD and subcaudate tractotomy with or without cingulotomy was done for depression. In twenty-three patients, the lesions were made by a radiofrequency (RF) lesion generator. In fifteen cases, the lesions were made with Cyberknife Radiosurgery (CKRS). The Overt Aggression Scale (OAS) declined from 8 to 2 with clinical improvement during follow up period. With long-term follow up (meaning 57 months) in 25 OCDs, the mean Yale Brown Obsessive Compulsive Score (YBOCS) declined from 34 to 13 (n = 25). The Hamilton Depression scale (HAMD) for ten patients with depression declined from 38.5 to 10.5 (n = 10). There was no operative mortality and no significant morbidity except one case with transient urinary incontinence. Authors suggest that stereotactic psychosurgery by RF and CKRS could be a safe and effective means of treating some medically intractable mental illnesses. (author) illnesses. (author)

  9. Secondary syphilis lesions resembling pityriasis

    International Nuclear Information System (INIS)

    This case report describes a male patient who presented with generalized, centrally-ulcerated papules with crusts and hypopigmented macules. Initially, differential diagnostic considerations included pityriasis lichenoides but the serology for syphilis was positive and there was a rapid response to penicillin with clearing of the lesions at the end of three weeks treatment. (author)

  10. Focal lesions of the patella

    International Nuclear Information System (INIS)

    Focal lesions of the patella may be identified during the investigation of anterior knee pain or as an incidental finding on radiological images. This pictorial review describes the radiographic appearances of a wide range of conditions that have been seen in this sesamoid bone. Where appropriate, computed tomography and magnetic resonance features have been included. (orig.)

  11. Osteochondral lesions in pediatric and adolescent patients.

    Science.gov (United States)

    Ghahremani, Shahnaz; Griggs, Rachel; Hall, Theodore; Motamedi, Kambiz; Boechat, M Ines

    2014-11-01

    Osteochondral lesions are acquired, potentially reversible injuries of the subchondral bone with or without associated articular cartilage involvement. Injury results in delamination and potential sequestration of the affected bone. Although an association with mechanical and traumatic factors has been established, the etiology remains poorly understood. These lesions commonly occur in the knee; articular surfaces of the elbow, ankle, hip, and shoulder are also affected. Osteochondral lesions are relatively common in children and adolescents, and the incidence is increasing. Prognosis of these lesions depends on stability, location, and size of the lesion.Imaging has an essential role in the diagnosis, staging, and management of osteochondral lesions. Many of these lesions are first diagnosed by plain film. MRI adds value by identifying unstable lesions that require surgical intervention. This review focuses on the clinical and imaging features of osteochondral lesions of the knee, elbow, and ankle. Imaging criteria for staging and management are also reviewed. PMID:25350829

  12. Petrous apex lesions in the pediatric population

    International Nuclear Information System (INIS)

    A variety of abnormal imaging findings of the petrous apex are encountered in children. Many petrous apex lesions are identified incidentally while images of the brain or head and neck are being obtained for indications unrelated to the temporal bone. Differential considerations of petrous apex lesions in children include ''leave me alone'' lesions, infectious or inflammatory lesions, fibro-osseous lesions, neoplasms and neoplasm-like lesions, as well as a few rare miscellaneous conditions. Some lesions are similar to those encountered in adults, and some are unique to children. Langerhans cell histiocytosis (LCH) and primary and metastatic pediatric malignancies such as neuroblastoma, rhabomyosarcoma and Ewing sarcoma are more likely to be encountered in children. Lesions such as petrous apex cholesterol granuloma, cholesteatoma and chondrosarcoma are more common in adults and are rarely a diagnostic consideration in children. We present a comprehensive pictorial review of CT and MRI appearances of pediatric petrous apex lesions. (orig.)

  13. Petrous apex lesions in the pediatric population

    Energy Technology Data Exchange (ETDEWEB)

    Radhakrishnan, Rupa [University of Cincinnati College of Medicine, Department of Radiology, Cincinnati, OH (United States); Cincinnati Children' s Hospital Medical Center, Department of Radiology, Cincinnati, OH (United States); Son, Hwa Jung [University of Cincinnati College of Medicine, Department of Otolaryngology-Head and Neck Surgery, Cincinnati, OH (United States); Koch, Bernadette L. [Cincinnati Children' s Hospital Medical Center, Department of Radiology, Cincinnati, OH (United States)

    2014-03-15

    A variety of abnormal imaging findings of the petrous apex are encountered in children. Many petrous apex lesions are identified incidentally while images of the brain or head and neck are being obtained for indications unrelated to the temporal bone. Differential considerations of petrous apex lesions in children include ''leave me alone'' lesions, infectious or inflammatory lesions, fibro-osseous lesions, neoplasms and neoplasm-like lesions, as well as a few rare miscellaneous conditions. Some lesions are similar to those encountered in adults, and some are unique to children. Langerhans cell histiocytosis (LCH) and primary and metastatic pediatric malignancies such as neuroblastoma, rhabomyosarcoma and Ewing sarcoma are more likely to be encountered in children. Lesions such as petrous apex cholesterol granuloma, cholesteatoma and chondrosarcoma are more common in adults and are rarely a diagnostic consideration in children. We present a comprehensive pictorial review of CT and MRI appearances of pediatric petrous apex lesions. (orig.)

  14. Imaging of Chest Wall Lesions in Children

    Directory of Open Access Journals (Sweden)

    A. Hekmatnia

    2008-01-01

    Full Text Available Chest wall lesions in childhood include a wide range of pathologies; Benign lesions include lipoma, neurofibroma, lymphangioma, hemangioma, and mesenchymal hamartoma."nMalignant lesions include Neuroblastoma, Rhabdo-myosarcoma, Ewing sarcoma, and Askin tumor."nSystemic diseases such as leukemia, lymphoma, Langerhans cell histiocytosis, and also infections such as tuberculosis, and actinomycosis may also cause chest wall lesions."nThe imaging characteristics of these lesions are re-viewed, but only a minority of the lesions shows diagnostic imaging features, and most of lesions re-quire biopsy and histopathological examination for "ndefinitive diagnosis."nThe role of different modalities is discussed with an emphasis on magnetic resonance imaging for demonstrating lesion morphology and local spread. Computed tomography and neuclear medicine being used mainly to assess remote disease."nIn this lecture, we discuss about imaging of chest wall lesions in children.

  15. Small temporal pole encephaloceles: a treatable cause of "lesion negative" temporal lobe epilepsy.

    Science.gov (United States)

    Abou-Hamden, Amal; Lau, Mandy; Fabinyi, Gavin; Berkovic, Samuel F; Jackson, Graeme D; Mitchell, L Anne; Kalnins, Renate; Fitt, Greg; Archer, John S

    2010-10-01

    Epilepsy due to encephaloceles of the temporal pole may be an under recognized, treatable cause of refractory temporal lobe epilepsy (TLE). We describe three adult patients initially labeled "lesion negative" TLE. In all, video–electroencephalography (EEG) revealed ictal theta in the left temporal region and positron emission tomography (PET) showed temporal lobe hypometabolism, but neuropsychology revealed preserved verbal memory. Close inspection of structural magnetic resonance imaging (MRI) suggested subtle abnormalities at the tip of the left temporal lobe. High resolution computed tomography (CT) confirmed bony defects in the inner table of the skull. 3T MRI with fine coronal and sagittal slices indicated cerebrospinal fluid (CSF) and brain tissue protruding into the defects. All proceeded to resection of the temporal tip and became seizure free. Patients with "lesion negative" TLE should have careful review of images covering the temporal pole. If encephalocele is suspected, further imaging with high-resolution CT and MRI can be helpful. Temporal polar resection, sparing mesial structures, appears to be curative. PMID:20384762

  16. Radiological Study on the Primary Tuberculous Lesions

    International Nuclear Information System (INIS)

    The simple chest X-ray study is essential in diagnosis of pulmonary tuberculosis, especially primary pulmonary tuberculosis. Authers analyzed the chest films and tuberculin tests of 521 cases which are suspected primary pulmonary tuberculosis clinically, from Jan. 1978 to Nov. 1982 at Seoul Red Cross Hospital. The results are as follows: 1. Among the total 521 cases, the 115 cases of chest film reveal 245 probable pulmonary tuberculous lesions. 2. The coincidence of the parenchymal and lymphnodal involvement are observed in 40 cases (34.8%) with 137 lesions (55.9%), parenchymal only in 23 cases (20.0%) with 25 lesions (10.2%) and lymphnodal only in 52 cases (45.2%) with 83 lesions (33.9%). 3. In observing the distribution of the 83 parenchymal lesions, the right lung is two times as common as that of the left, being the highest in the RLL field with 41 lesions (49.4%), the lowest in the LLL field with 3 lesions (3.6%). 4. In observing the distribution of the 162 lymphnodal lesions, there are 95 lesions (58.6%) in the right and 67 lesions (41.4%) in the left, involving hilar nodes with 150 lesions (92.6%) and mediastinal nodes with 12 lesions (7.4%). The incidence of unilateral involvement is 13 cases (11.3%) and bilateral 79 cases (68.7%). 5. Among the total 245 lesions, 141 lesions (57.5%) are smaller than rice in size, 120 lesions (49.0%) are amorphous in shape and 186 lesions (75.9%) are mainly calcific in density. According to the increase of age, count and detectg to the increase of age, count and detection rate of the lesion on the chest film are increased. 6. Tuberculin tests showed 26.1% negative rate in 115 tuberculous cases, and 51% positive rate in 406 negative chest cases.

  17. Radiologic findings of thoracic inlet lesions

    International Nuclear Information System (INIS)

    We performed this study to evaluate the incidence of thoracic inlet pathologies. We also evaluated the extension of the thoracic inlet lesions to neck and/or mediastinum to determine anatomic connections between neck and mediastinum. We evaluated chest radiographs and CT scans of the 41 patients with various pathologies involving this region. Thyroid lesions and malignant lymphomas were the most common pathologic lesions in this region (54%). Thoracic inlet lesions extending from mediastinum included various pathologies including thymic lesion(n=8) in the anterior mediastinum, neurogenic tumor(n=2) in the posterior mediastinum and malignant lymphoma(n=5) in the multiple compartment. Thoracic inlet lesions extending from the neck(n=9) were mostly thyroid lesions(n=8) arising in the visceral space of the neck. Thoracic inlet lesion(n=11) involving both neck and mediastinum were thyroid lesions, abscesses, thymic lesion, malignant lymphomas and cavernous hemangiomas. Thyroid lesions and cavernous hemangiomas showed remarkable enhancement on post contrast enhanced CT. Teratoma contained fat density and two cases of abscesses contained air density. Thyroid lesions and malignant lymphomas were the most common pathologies in the thoracic inlet. There was anatomic connection between neck and mediastinum through the thoracic inlet. CT was valuable in evaluation of the location, extension. and density of the mass for the differential diagnosis of the thoracic inlet lesionsagnosis of the thoracic inlet lesions

  18. Evaluation of hepatic cystic lesions

    OpenAIRE

    Lantinga, Marten A.; Jg, Tom Gevers; Ph, Joost Drenth

    2013-01-01

    Hepatic cysts are increasingly found as a mere coincidence on abdominal imaging techniques, such as ultrasonography (USG), computed tomography (CT) and magnetic resonance imaging (MRI). These cysts often present a diagnostic challenge. Therefore, we performed a review of the recent literature and developed an evidence-based diagnostic algorithm to guide clinicians in characterising these lesions. Simple cysts are the most common cystic liver disease, and diagnosis is based on typical USG char...

  19. CT evaluation of benign gastric lesions

    OpenAIRE

    K Gossios, E. Tsianos

    2007-01-01

    SUMMARY This pictorial review demonstrates CT features of benign gastric lesions. CT features are non-specific and frequently overlap. Familiarity with the most specific findings on CT may be useful for diagnosis. Key words: Computed tomography, benign gastric lesions.

  20. Maxillofacial fibro-osseous lesions.

    Science.gov (United States)

    MacDonald, D S

    2015-01-01

    During the last decade much has changed in our understanding of fibro-osseous lesions (FOLs) of the jaws with regards to their imaging, their nomenclature and classification, and their potential impact on the overall health of the patient. The changes in nomenclature, classification, and the FOLs' potential association with important syndromes are discussed with the assistance of a flowchart. The lesions, fibrous dysplasia (FD), ossifying fibroma (OF), and osseous dysplasia (OD), though with similar histopathology, have very different clinical and radiological presentations, behaviour, and treatment outcomes. FD of the jaw, which though becoming inactive, does not involute and therefore requires life-long review to monitor for occasional reactivation. OF is completely removed surgically as it has a propensity to recur. No treatment is generally required for an OD unless it is infected or displays expansion. Lesions outside the jaws associated with FOLs of the jaws are identified. Radiology remains central to the diagnosis of FOLs of the jaw, because the pathologist is still not able to distinguish between them. The advent of cone-beam computed tomography (CBCT) with its better radiation dose reduction, accessibility, and spatial resolution has transformed imaging of FOLs. Their presentations on CBCT and the clinical indications for its use are discussed. PMID:25439185

  1. Automatic segmentation of psoriasis lesions

    Science.gov (United States)

    Ning, Yang; Shi, Chenbo; Wang, Li; Shu, Chang

    2014-10-01

    The automatic segmentation of psoriatic lesions is widely researched these years. It is an important step in Computer-aid methods of calculating PASI for estimation of lesions. Currently those algorithms can only handle single erythema or only deal with scaling segmentation. In practice, scaling and erythema are often mixed together. In order to get the segmentation of lesions area - this paper proposes an algorithm based on Random forests with color and texture features. The algorithm has three steps. The first step, the polarized light is applied based on the skin's Tyndall-effect in the imaging to eliminate the reflection and Lab color space are used for fitting the human perception. The second step, sliding window and its sub windows are used to get textural feature and color feature. In this step, a feature of image roughness has been defined, so that scaling can be easily separated from normal skin. In the end, Random forests will be used to ensure the generalization ability of the algorithm. This algorithm can give reliable segmentation results even the image has different lighting conditions, skin types. In the data set offered by Union Hospital, more than 90% images can be segmented accurately.

  2. Lytic clavicular lesions in fibromatosis colli

    Energy Technology Data Exchange (ETDEWEB)

    Sartoris, D.J.; Parker, B.R.; Mochizuki, R.M.

    1983-06-01

    Two patients with fibromatosis colli (congenital torticollis) presented with lytic lesions in the clavicle at the insertion of the fibrosed clavicular head of the sternocleidomastoid muscle. Biopsy of one lesion showed intraosseous fibrosis. These lesions are probably not uncommon but radiographs are rarely performed in uncomplicated cases.

  3. CLASSIFYING NODULAR LESIONS OF ORAL CAVITY

    OpenAIRE

    Sumit Bhateja

    2013-01-01

    Diagnosis of many lesions of the oral cavity is challenging to most cliniciansbecause of their uncommon prevalence. A number of cystic, osteodystrophic,microbial, tumor and tumor like lesions of the oral cavity are present withcharacteristic exophytic/raised surface; which makes their diagnosis and studysimpler. The present article is attempted at classifying the common nodular lesions ofthe oral cavity.

  4. Lack of bone lesions at diagnosis is associated with inferior outcome in multisystem langerhans cell histiocytosis of childhood.

    Science.gov (United States)

    Aricò, Maurizio; Astigarraga, Itziar; Braier, Jorge; Donadieu, Jean; Gadner, Helmut; Glogova, Evgenia; Grois, Nicole; Henter, Jan-Inge; Janka, Gritta; McClain, Kenneth L; Ladisch, Stephan; Pötschger, Ulrike; Rosso, Diego; Thiem, Elfriede; Weitzman, Sheila; Windebank, Kevin; Minkov, Milen

    2015-04-01

    Skeletal involvement is generally, but not universally, characteristic of Langerhans cell histiocytosis (LCH). We investigated whether the presence of bone lesions at diagnosis is a prognostic factor for survival in LCH. Nine hundred and thirty-eight children with multisystem (MS) LCH, both high (386 RO+) and low (RO-) risk, were evaluated for bone lesions at diagnosis. Risk organ (RO+) involvement was defined as: haematopoietic system (haemoglobin 2 cm below the costal margin), liver (>3 cm and/or hypoproteinaemia, hypoalbuminaemia, hyperbilirubinaemia, and/or increased aspartate transaminase/alanine transaminase). Given the general view that prognosis in LCH worsens with increasing extent of disease, the surprising finding was that in MS+RO+ LCH the probability of survival with bone involvement 74 ± 3% (n = 230, 56 events) was reduced to 62 ± 4% (n = 156, 55 events) if this was absent (P = 0·007). An even greater difference was seen in the subgroup of patients with both liver and either haematopoiesis or spleen involvement: 61 ± 5% survival (n = 105; 52 events) if patients had bony lesions, versus 47 ± 5% (n = 111; 39 events) if they did not (P = 0·014). This difference was retained in multivariate analysis (P = 0·048). Although as yet unexplained, we conclude that bone involvement at diagnosis is a previously unrecognized favourable prognostic factor in MS+RO+ LCH. PMID:25522229

  5. Transitional carcinoma with extensive invasion of the bony orbit in a dog / Carcinoma transicional com invasão dos ossos da órbita em um cão

    Scientific Electronic Library Online (English)

    S.C.C.S., Paiva; J., Werner; F., Montiani-Ferreira; T.R., Froes; M., Machado; L., Olbertz; L., Lima; I., Langohr.

    1017-10-01

    Full Text Available Um cão da raça Pointer Inglês, de 12 anos de idade, foi encaminhado para avaliação clínica por apresentar aumento de volume no canto temporal (medial) da órbita direita, o qual estava causando deformidade facial. O cão apresentava epífora, secreção nasal mucopurulenta, epistaxe, dispnésia e perda de [...] peso progressiva. Uma massa foi observada na cavidade oral, próxima aos dentes pré-molares, do lado direito da face. Suspeitou-se de proliferação neoplásica baseando-se nos testes auxiliares, entre os quais: radiografia craniana e oral, ultrassonografia ocular e tomografia computadorizada. A análise histopatológica da massa revelou tratar-se de carcinoma transicional envolvendo as cavidades oral e nasal, os ossos da maxila e da órbita, além do espaço retrobulbar. Os tumores da cavidade nasal representam aproximadamente 2% de todos os tumores diagnosticados nessa espécie. O carcinoma transicional é o segundo tipo de neoplasia epitelial maligna mais comum nos seios nasais de cães. Este trabalho descreve a destruição extensiva dos tecidos moles e dos ossos da face e chama atenção para o fato de que esse tipo de neoplasia deve ser considerado nas doenças da órbita. Abstract in english A 12-year-old male English Pointer was examined due to a soft-tissue swelling at the medial canthus of the right orbital region, which was causing facial deformity. The dog had epiphora, purulent nasal discharge, epistaxis, dyspnea, and progressive weight loss. An intraoral mass was observed near th [...] e right maxillary premolars. Neoplastic disease was diagnosed based on ancillary tests, which included blood work, skull and intraoral radiographs, ocular ultrasonography and computed tomography. Histopathology revealed transitional carcinoma involving the nasal and oral cavities, maxilla, bony orbit and retrobulbar space. Nasal tumors represent approximately 2% of all tumors diagnosed in this species. Transitional carcinoma is the second most common type of malignant epithelial tumor in the nasal sinuses. This case illustrates the extensive destruction of the soft and bony tissues of the face, including the bony orbit that this type of tumor can cause.

  6. Optimization of hepatic lesion detection with computed tomography (CT): Is randomization of lesion location necessary?

    Science.gov (United States)

    Dobeli, K.; Lewis, S.; Meikle, S.; Thiele, D.; Brennan, P. C.

    2011-03-01

    Purpose: The purpose of this study was to compare observer performance for the detection of randomly-positioned lesions to that of location-known lesions to determine if randomization of lesion placement is necessary for optimization of hepatic lesion detection with CT. A phantom containing fixed lesions (diameter 2.4mm, 4.8mm and 9.5mm) was scanned at various exposure and slice thickness settings. A second image set was created by electronically cutting lesions from the phantom images and pasting them into background-only images. Nine observers, blinded to lesion location in the second image set, reviewed all images under standardized viewing conditions. Visualization of lesions was scored using a four-point scale. Observer scores for the two methods were correlated for all lesions, and for each lesion size using Spearman's rank correlation coefficient (r). There was very high correlation between the observer scores for all lesions (r=0.919, pdose optimization. For the smaller lesion sizes correlation between the two methods is less robust. Conclusion: If lesion size is large or unimportant, dose optimization can be performed using a phantom with fixed lesions. For small lesions, randomized lesion location may be warranted, thus having implications for phantom design.

  7. Solitary lucent epiphyseal lesions in children

    International Nuclear Information System (INIS)

    We evaluated retrospectively the varying radiographic appearances of 15 solitary lucent epiphyseal lesions occurring in children. Imaging modalities used included plain films, conventional tomography, nuclear scintigraphy, and computed tomography. 40% of the lesions (6) were due to osteomyelitis. The remaining lesions included tuberculosis (1), foreign body granuloma (1), chondroblastoma (2), chondromyoxid fibroma (1), enchondroma (1), osteoid osteoma (2), and eosinophilic granuloma (1). Although the radiographic appearances of such lesions may be particularly characteristic, pathologic correlation is frequently necessary. The high incidence of osteomyelitis in our cases emphasizes its importance as a cause for a lucent epiphyseal lesion. (orig.)

  8. Feline odontoclastic resorptive lesions: unveiling the early lesion.

    Science.gov (United States)

    Gorrel, C; Larsson, A

    2002-11-01

    The purpose of this study was to increase understanding of the factors initiating feline odontoclastic resorptive lesions (FORLs). Fifty-six teeth (clinically and radiographically unaffected by ORLs) were harvested. Of these, 43 were from cats that had ORLs in other teeth (group A) and 13 were from cats with no clinical or radiographic evidence of ORLs in any teeth (group B). Twenty-six teeth in group A and one tooth in group B showed histological evidence of external root resorption (surface resorption and replacement resorption resulting in ankylosis). Some teeth in group B showed healed cementum resorption. It has previously been assumed that FORLs were similar to lesions associated with peripheral inflammatory root resorption, and were associated with periodontal disease. These histological findings suggest instead that a FORL is a non-inflammatory replacement resorption, resulting in ankylosis. The periodontal ligament of resorbing teeth lacked normal fibrous architecture, but was not inflamed. Resorption was not identified in cervical cementum. However, the histological appearance of the cervical cementum differed between the two groups. Several aetiopathogenetic explanatory models which arise from these observations are discussed. PMID:12463263

  9. Cystic renal lesions; Zystische Nierenlaesionen

    Energy Technology Data Exchange (ETDEWEB)

    Kreft, B. [Univ. Bonn, Radiologische Klinik (Germany); Schild, H.H.

    2003-07-01

    Cystic renal lesions are most often simple or complicated cysts, which can be seen solitary or as part of cystic renal disease. The minority of these lesions are benign or malignant cystic tumors. The classification of cystic renal masses by Bosniak (category I-IV) based on specific ultrasound and CT features is very useful for the characterization of the lesion and for the therapeutic decision. The main objective of this classification is to differentiate nonsurgical (category II) from surgical cystic masses (category III/IV). Ultrasound is the first modality of choice in the diagnostic work-up of cystic renal masses, because an accurate and economically reasonable diagnosis of the frequent simple cyst can be made by maintaining rigid ultrasound criteria of the Bosniak classification. If a complicated cyst or a cystic tumor is suspected a threephasic contrast-enhanced CT of the kidneys should be performed. MRI is superior to CT in the characterization of complex cystic masses. (orig.) [German] Bei zystischen Nierenlaesionen handelt es sich meist um einfache oder komplizierte Zysten, die sowohl solitaer als auch im Rahmen von zystischen Nierenerkrankungen auftreten. Zu einem geringen Anteil liegen benigne oder maligne zystische Raumforderungen vor. Die Klassifikation von zystischen Laesionen (Kategorie I-IV) anhand von sonographischen und computertomographischen Kriterien nach Bosniak ist sehr nuetzlich fuer die Charakterisierung der Laesion und fuer die Entscheidung ueber das therapeutische Vorgehen. Das Hauptziel dabei ist, operative Eingriffe bei Zysten der Kategorie II zu vermeiden und diese von den Zysten der Kategorie III bzw. IV zu differenzieren, die eine operative Exploration benoetigen. Bei der Abklaerung zystischer Nierenlaesionen ist die Sonographie die Untersuchungsmodalitaet der Wahl, da unter Beachtung der entsprechenden Kriterien der Bosniak-Klassifikation eine sichere und oekonomisch sinnvolle Diagnose der sehr haeufigen einfachen Zyste gestellt werden kann. Falls der Verdacht auf eine komplizierte Zyste oder einen zystischen Tumor gestellt wird, sollte eine dreiphasige kontrastverstaerkte Spiral-CT der Nieren erfolgen. Die MRT besitzt gegenueber der CT Vorteile in der Dignitaetsbeurteilung komplexer zystischer Raumforderungen. (orig.)

  10. Diffusion-weighted imaging of skull lesions.

    Science.gov (United States)

    Ginat, Daniel T; Mangla, Rajiv; Yeaney, Gabrielle; Ekholm, Sven

    2014-06-01

    Diffusion-weighted imaging can increase the conspicuity of skull lesions and be applied toward noninvasive differentiation of malignant from benign lesions. Malignant skull lesions generally display lower diffusivity than benign lesions, although there are exceptions, and clinical parameters and conventional imaging modalities should also be considered in the evaluation of skull lesions. Nevertheless, in some instances diffusion-weighted imaging (DWI) can be used for problem solving when conventional imaging features are indeterminate, such as with skull base involvement by nasopharyngeal carcinoma versus osteomyelitis. In addition, DWI may be useful for monitoring treatment effects. The use of readout segmented technique, parallel imaging, multishot acquisition, turbo spin-echo DWI, diffusion tensor imaging, and higher field strengths can improve image quality. The feasibility of implementing DWI for characterizing skull lesions, the DWI findings of benign and malignant skull lesions, and technical considerations are discussed in this article. PMID:25072014

  11. Skeletal muscle lesion in AIDS

    International Nuclear Information System (INIS)

    This paper presents a differential diagnosis of skeletal muscle lesions in acquired immunodeficiency syndrome (AIDS) and to assess potential radiologic means of distinguishing between them. The findings of MR imaging in 11 patients, three-phase Tc-99m methylene diphosphonate scintigraphy (MDP) in three, and In-111 leukocyte scintigraphy in two were compared. Diagnoses included pyomyositis (PM, n = 6), Kaposi sarcoma (KS, n = 2), and unknown (n = 5). Organisms in PM included Staphylococcus aureus in five patients (one also with Mycobacterium avium-intracellulare) and Streptococcus pyrogenes in one. MR imaging suggested fluid collections in four cases of PM (which were drained) and diffuse abnormality in the others

  12. Osteochondral talar lesions and defects.

    Science.gov (United States)

    Seiter, Jason L; Seiter, Kenneth P

    2012-10-01

    Talar dome lesions (TDL) have increasingly been the focus of interest of many foot and ankle surgeons over the past decade. The most important treatment aspect of TDL is diagnosis, so that appropriate treatment protocols can be enacted in a timely and stepwise manner. Minor or mild TDL may be treated conservatively, while severe acute or chronic TDL can be addressed with various surgical interventions. By being aware of all practical treatment options and their indications, success rates, benefits, risks, and alternative options, specialists will be able to make an informed decision on appropriate care selection after perusing this article. PMID:23044058

  13. Effect of decompression surgery on neurological recovery after cervical cord injury with canal stenosis but without distinct bony damage. Multicenter prospective randomized clinical trial

    International Nuclear Information System (INIS)

    A prospective randomized clinical trial examining the effects of decompression surgery on neurological recovery in patients with cervical cord injuries without remarkable bony damages was performed at 11 hospitals nationwide in Japan. Cases admitted within 14 days of injury, with a Frankel B or C classification, and with ?20% compression of the spinal cord at the injured level, as seen on MRI, were enrolled. Decompression surgery was selected for cases in which the day of injury was an odd number, while conservative treatment was selected for all other cases. The Frankel classification and ASIA motor scores were followed for one year after injury. No statistically significant differences in neurological recovery were observed between the surgery group and the conservative treatment group. (author)

  14. X-ray-assisted positioning of patients treated by conformal arc radiotherapy for prostate cancer: Comparison of setup accuracy using implanted markers versus bony structures

    International Nuclear Information System (INIS)

    Purpose: The aim of this study was to compare setup accuracy of NovalisBody stereoscopic X-ray positioning using implanted markers in the prostate vs. bony structures in patients treated with dynamic conformal arc radiotherapy for prostate cancer. Methods and Materials: Random and systematic setup errors (RE and SE) of the isocenter with regard to the center of gravity of three fiducial markers were measured by means of orthogonal verification films in 120 treatment sessions in 12 patients. Positioning was performed using NovalisBody semiautomated marker fusion. The results were compared with a control group of 261 measurements in 15 patients who were positioned with NovalisBody automated bone fusion. In addition, interfraction and intrafraction prostate motion was registered in the patients with implanted markers. Results: Marker-based X-ray positioning resulted in a reduction of RE as well as SE in the anteroposterior, craniocaudal, and left-right directions compared with those in the control group. The interfraction prostate displacements with regard to the bony pelvis that could be avoided by marker positioning ranged between 1.6 and 2.8 mm for RE and between 1.3 and 4.3 mm for SE. Intrafraction random and systematic prostate movements ranged between 1.4 and 2.4 mm and between 0.8 and 1.3 mm, respectively. Conclusion: The problem of interfraction prostate motion can be solved by using implanted markers. In addition, the NovalisBody X-ray system performs more accurvalisBody X-ray system performs more accurately with markers compared with bone fusion. Intrafraction organ motion has become the limiting factor for margin reduction around the clinical target volume

  15. Evaluation by biphotonic absorbtiometry of the bony mineral content and determination of the fracture threshold in a population of patients between the ages of 60 and 75 years

    International Nuclear Information System (INIS)

    A measurement of the bony density of vertebrae and femur was carried out, in the course of a prospective study, in 99 patients between the ages of 60 and 75 years, living in northern France. 76 patients had no recognized problem of demineralization and 23 others were consulting for an evaluation of vertebral compression. The measurement of the bony density was done by biphotonic absorbtiometry with a source of labelled Gadolinium. In women, a significant difference in the values obtained by absorbtiometry in terms of the existence of vertebral compressions, symptomatic or not, is noted. A statistical study using the ROC curves method (Receiver Operating System) has enabled us to determine a threshold of high risk of vertebral fracture measured at 31 g or 0.85 g/cm2 in women, and 35 g or 0.85 g/cm2 in men. In addition, there is a significant correlation with the vertebral radiographical index as defined by Meunier. Among the various factors of influence which were studied, only the size and the morphotype seem to play an essential role in our study group. The comparative study of the densities measured in the femoral neck and the lumbar spine enabled us to find a very significant correlation in patients with as well as without compression (r = 0.714, p < 0.001). Biphotonic absorbtiometry proves therefore to be a method which may be used to define a group with a high fracture risk permitting to determine, as early as possible, therapeutic, curatives early as possible, therapeutic, curative and preventive measures

  16. Correlation between rate of bony ingrowth to stainless steel, pure titanium, and titanium alloy implants in vivo and formation of hydroxyapatite on their surfaces in vitro.

    Science.gov (United States)

    Oron, A; Agar, G; Oron, U; Stein, A

    2009-12-15

    The rate of bony ingrowth to identical metal implants made of either pure titanium (cpTi), titanium alloy (Ti-6Al-4V), or stainless steel 316L (SS) inserted to the medullar canal of the femur in rats was investigated. The kinetics of spontaneous deposition of hydroxyapatite (HA) globules on the aforementioned metals in vitro during incubation in simulated body fluid (SBF) was also studied. It was found that the rate of increased bonding strength between the cpTi implants and the host bone was the highest, whereas around the SS implants it was the slowest. At 10 days postimplant insertion, the shear strength of the cpTi implants was 2.2- and 4-fold significantly higher than for the Ti-6Al-4V and the SS implants, respectively. Spontaneous formation of the HA globules on the cpTi and Ti-6Al-4V implants that were incubated in the SBF was observed as early as 6 and 10 days after incubation in SBF, respectively, whereas on SS implants, deposition of HA was evident only after 2 weeks of in vitro incubation in SBF. It is concluded that the chemical surface characteristics and the biocompatibility of the implants probably play a key role in the process of bone growth next to them, during the formation of bone in vivo. The rate of bony ingrowth to various metal implants alloys inserted into the medullar canal of rats correlates well with the induction of apatite formation on them during incubation in vitro with SBF. PMID:19097149

  17. A Comparison of Soft-Tissue Implanted Markers and Bony Anatomy Alignments for Image-Guided Treatments of Head-and-Neck Cancers

    International Nuclear Information System (INIS)

    Purpose: To compare the geometric alignments of soft-tissue implanted markers to the traditional bony-based alignments in head-and-neck cancers, on the basis of daily image guidance. Dosimetric impact of the two alignment techniques on target coverage is presented. Methods and Materials: A total of 330 retrospective alignments (5 patients) were performed on daily megavoltage computed tomography (MVCT) image sets using both alignment techniques. Intermarker distances were tracked for all fractions to assess marker interfractional stability. Using a deformable image registration algorithm, target cumulative doses were calculated according to generated shifts on daily MVCT image sets. Target D95 was used as a dosimetric endpoint to evaluate each alignment technique. Results: Intermarker distances overall were stable, with a standard deviation of <1.5 mm for all fractions and no observed temporal trends. Differences in shift magnitudes between both alignment techniques were found to be statistically significant, with a maximum observed difference of 8 mm in a given direction. Evaluation of technique-specific dose coverage based on D95 of target clinical target volume and planning target volume shows small differences (within ±5%) compared with the kilovoltage CT plan. Conclusion: The use of daily MVCT imaging demonstrates that implanted markers in oral tongue and soft-palate cancers are stable localization surrogates. Alignments based on implanted markers generate shiftsased on implanted markers generate shifts comparable overall to the traditional bony-based alignment, with no observed systematic difference in magnitude or direction. The cumulative dosimetric impact on target clinical target volume and planning target volume coverage was found to be similar, despite large observed differences in daily alignment shifts between the two techniques.

  18. Photodynamic treatment of oral lesions.

    Science.gov (United States)

    Kvaal, Sigrid I; Warloe, Trond

    2007-01-01

    Photodynamic treatment (PDT) was first started in the oral cavity in the mid 1980s. Hematoporphyrins were rapidly replaced by Photofrin and meta-tetrahydroxyphenylchlorin (mTHPC) as photosensitisers of choice, and over the years these two have been approved by several health authorities for PDT. 5-aminolevulinic acid (ALA) and some dyes (e.g., toluidine and methyene blue) have also been tested. Several different nonthermal lasers have been used and lately light-emitting diodes (LEDs) have been tried. Most of the clinical treatments have been carried out on oral squamous cell carcinoma (OSSC), either primary or metastatic lesions, with good results. The treatment leaves little scarring and can be used before, in conjunction with, and adjunctive to other treatment modalities. The greatest disadvantage is that the patients are photosensitive for several weeks following systemic administration of the photosensitiser. PDT is now an accepted palliative treatment. Systemic administration of ALA has been more successful than local application in the treatment of precancerous lesions such as oral leukoplakia. PDT following topical application of photosensitiser (metylene blue and methyl-ALA) has shown improvement in cutaneous diseases of the oral mucous membrane such as oral lichen planus. The bactericidal effect of PDT has also been tested on oral plaque, but little clinical work has been performed so far. Instead of mechanical cleaning or antibiotic therapy, PDT may also play a role in dental diseases. PMID:17725538

  19. Leucocyte mobilization to skin lesions

    International Nuclear Information System (INIS)

    Leucocyte mobilization to a chamber covering a skin lesion was studies in healthy volunteers.111Indium-labelled blood leucocytes accumulated in the chambers, indicating mobilization of leucocytes from the blood. The concentration of autologous serum in the chamber medium influenced the number of leucocytes mobilized, while heat inactivation of serum or the repeated use of the same serum had no effect on the counts. The use of zymosan-treated increased the mobilization by up to 53 %. The kinetics for the mobilization of leucocytes to chambers containing autologous serum was followed in healthy subjects. The mobilization showed a uniform pattern, viz. a lag phase of 2-4 hours and maximal migration rates after 20-24 hours. The cumulated counts were 74 x 106 leucocytes/cm2/24 hours and 200 x 106leucocytes/cm2/48 hours. Females and males exhibited the same kinetics and cumulated counts. Chamber leucocytes were predominantly neutrophil granulocytes (85-100 %) with 2.9-3.6 nuclear segments. The chamber technique provides a simple method permitting quantitation of in vivo mobilization of leucocytes from the blood to an inflammatory lesion. (author)

  20. Benign Eyelid Lesions: Six Months Study

    Directory of Open Access Journals (Sweden)

    E Abbasi Shavvazi

    2013-04-01

    Full Text Available Introduction: Benign eyelid lesions are classified to infectious, inflammatory and tumoral lesions. The various number of these lesions is due to unique eyelid anatomical structure. Some lesions are simple and do not need any treatment but sometimes patients refer to ophthalmologists due to beauty or problems such as pain, swelling. The aim of our study is to investigate and compare the relative frequency of benign eyelid lesions in Shahid Sadoughi eye clinic as well as the private offices. Methods: This cross sectional six month study was done on 247 patients who referred to Shahid Sadoughi eye clinic and the private offices in 2011. They were examined by direct observation and slit lamp regardless of the cause. The information was gleaned by a questionnaire and the research data was analyzed by SPSS (ver.16. Results: we studied 247 patients including 84(34% male and 163(6% female. The mean age of the patients was 42.7 years. 60.2% of lesions were in upper lid and 39.8% were in lower lid. 51.2% of lesions were in right eye and 48.8% were in left eye. The most common eyelid lesions were papilloma (32.9% nevus (21.9% and chalazion (14.1% respectively. Conclusion: Papilloma, nevus and chalazion are respectively the most common lesion in men and women. Benign lesions were more common in women located more in upper lid, though there was no statistically difference between right and left lid.

  1. Minimally invasive approach for small ventrally located intradural lesions of the craniovertebral junction.

    Science.gov (United States)

    Eicker, Sven O; Mende, Klaus Christian; Dührsen, Lasse; Schmidt, Nils Ole

    2015-04-01

    OBJECT The surgical management of lesions ventral to the neuraxis at the level of the craniovertebral junction (CVJ) and upper cervical spine is challenging. Here, the authors describe a minimally invasive dorsal approach for small ventrally located intradural lesions at the CVJ as an alternative for the more extensive classic transoral approach or variants of suboccipital approaches. METHODS Between 2012 and 2014, 6 symptomatic patients with a small lesion of the ventral aspect at the CVJ level were treated using a minimally invasive dorsal approach at the University Medical Center in Hamburg-Eppendorf, Germany. The anatomical distance between the posterior atlantooccipital membrane and the posterior atlantoaxial ligament, as determined by CT images, was assessed in the treated patients and in 100 untreated persons. RESULTS The authors treated 6 patients (mean age 54.7 years) who had a clinical presentation of mild neurological symptoms that disappeared after resection. Minimally invasive surgical dorsal access was achieved by using tubular systems and using the natural space between the occiput (C-0) and C-1, and in 1 case between C-1 and C-2, without having to remove bony structures. The postoperative course in each of the 6 patients was uneventful. The neuropatho-logical findings confirmed a meningotheliomatous meningioma (WHO Grade I) in 5 cases and an extramedullary cavernous hemangioma in 1 case. MRI confirmed complete resection of all the lesions. The atlantooccipital distances ranged from 3 to 17 mm (mean 8.98 mm) in the supine neutral position, and the atlantoaxial distances ranged from 5 to 17 mm (mean 10.56 mm). There were no significant differences between women and men (atlantooccipital p = 0.14; atlantoaxial p = 0.72). CONCLUSIONS The results of this study demonstrate that the minimally invasive dorsal approach using the space between C-0 and C-1 or C-1 and C-2 provides direct and sufficient exposure for the safe surgical resection of small ventrally located intradural lesions at the CVJ level while reducing the necessity for musculoskeletal preparation to a minimum. PMID:25828486

  2. Subtraction radiography of interradicular bone lesions

    International Nuclear Information System (INIS)

    Subtraction and conventional radiography were evaluated for their diagnostic potential to assess interradicular bone lesions in the mandibular premolar region. Both conventional radiographs and subtraction images were interpreted by 10 observers. The receiver-operating characteristic technique was used to compare the two techniques. The diagnostic validity was higher for the subtraction technique, both for lesions confined to cancellous bone and for lesions including the cortical bone, than for the conventional technique. For bone defects confined to cancellous bone the diagnostic accuracy was lower than those reported from periapical bone lesion irrespective of whether subtraction or conventional radiography was used. It is concluded that subtraction radiography improves the detectability of bone lesions, shallow ones in particular. Lesions in the interradicular bone are more difficult to detect than those in the periapical bone. 26 refs., 3 figs., 2 tabs

  3. Bullous lesions detected by computed tomography

    International Nuclear Information System (INIS)

    An analysis was made of bullous emphysema detected by plain chest radiography and computed tomography (CT). Bullous lesions were detected in 43 of 214 patients who had thoracic CT as a further assessment of their pulmonary, pleural, and mediastinal abnormalities. Plain chest radiography failed to detect the bullous lesions in 17 (39.5 %) out of the 43 patients. Bullous lesions unrecognizable on plain radiographs ranged from 1.0 to 2.0 cm in size, were few in number, and were situated on the mediastinal side of the lung in many patients. CT is a sensitive method for detecting bullous lesions. Therefore, we consider it necessary to perform CT when needle biopsy for a previously known pulmonary lesion is taken into account, because knowledge of coexisting bullous lesions may be useful in preventing the occurrence of severe pneumothorax as complication. (author)

  4. Bacteriology of diabetic foot lesions

    Directory of Open Access Journals (Sweden)

    Anandi C

    2004-01-01

    Full Text Available Clinical grading and bacteriological study of 107 patients with diabetic foot lesions revealed polymicrobial aetiology in 69 (64.4% and single aetiology in 21 (19.6%. Among 107 patients 62 had ulcer. Of these 31 had mixed aerobes. Twenty six patients with cellulitis and 12 with gangrene had more than 5 types of aerobes and anaerobes such as E.coli, Klebsiella spp., Pseudomonas spp., Proteus spp., Enterobactor spp., Enterococci spp., Clostridium perfringens, Bacteroides spp., Prevotella spp. and Peptostreptococcus spp. It was noted that 50 out of 62 patients with ulcer, and all the patients with cellulitis and gangrene were given surgical management and treated with appropriate antibiotics based on antimicrobial susceptibility testing.

  5. Lesions of the Bartholin gland: a review.

    Science.gov (United States)

    Heller, Debra S; Bean, Sarah

    2014-10-01

    Most lesions of the Bartholin gland are cysts or abscesses. Clinicians are taught that lesions of the Bartholin gland occurring in older women should raise the differential diagnosis of malignancy, although these are uncommon. A variety of more unusual and rare lesions of the Bartholin gland have been reported. This review focuses on these less common entities, which must be considered as well when encountering pathology of the Bartholin gland. PMID:24914884

  6. Skin Lesion Segmentation Algorithms using Edge Detectors

    OpenAIRE

    Jaseema Yasmin, J. H.; Mohamed Sathik, M.

    2011-01-01

    An effective segmentation algorithm using log edge detector, for border detection of real skin lesions is presented which insinuate the excessive growth or regression of a melanoma, that helps in early detection of malignant melanoma and its performance is compared with the segmentation algorithm using canny detector, developed by us previously for border detection of real skin lesions. The experimental results demonstrate the successful border detection of noisy real skin lesions by the effe...

  7. Radiologic aspects of the Galeazzi lesion

    International Nuclear Information System (INIS)

    In lesions of the forearm that included a fracture of the distal two thirds of the radial shaft, a concomitant disruption of the distal radio-ulnar joint was found in 20 out of 38 cases. In 15 cases a typical Galeazzi lesion was present. Dislocation of the distal radio-ulnar joint frequently goes unrecognized. The clinical significance of a lesion in the distal radio-ulnar joint is related to its prognostic value. (orig.)

  8. Localization of lesions in aphasia, (2)

    International Nuclear Information System (INIS)

    The relationship between the focus and the extent of the lesions and the various symptoms was investigated. 1. Broca aphasics: More than 80% of the group with obvious anarthric components had lesions of the third frontal gyrus involving Broca's area and the lower part of the precental gyrus as well as opercular and insular regions. The size of the lesions of this group was significantly larger than that of the group without marked anarthric components, and the latter was proved to have little localizing value. 2. Wernicke aphasics: The group with poor reading comprehension had cortical and/or subcortical lesions, involving posterior parts of both superior and middle temporal gyri as well as the supramarginal gyrus. On the other hand, lesions of the group with poor auditory comprehension were more anteriorly located and localized in the deep structures. Lesions of the group with poor Token test scores were large and scattered more anteriorly and/or posteriorly compared with those of the group with good Token test scores. 3. Amnestic aphaiscs: The group with poor naming scores had somewhat larger lesions than the group with good naming scores, and the lesions were scattered about the left hemisphere. The finding has proved that both groups had little localizing value. 4. Conduction aphasics: Lesions of the non-fluent type were significantly larger than those of the fluent type and distributed more anteriorly. However, highly involved lesions were located in the supramarolved lesions were located in the supramarginal gyrus and posterior parts of superior and/or middle temporal gyri. 5. Global aphasics: Lesions of the group with good articulation and prosody were observed to distribute more posteriorly in comparison with those of the other global aphasics. (J.P.N.)

  9. Diagnostic Concordance Characteristics of Oral Cavity Lesions

    OpenAIRE

    Ufuk Tatli; An, Xd Zg Xfc R. Erdo X. F.; Uz, Aysun U. X. F.; Yakup Üstün; Ya?ar Sertdem?r; Brahim Damlar, X.

    2013-01-01

    Purpose. The objective of this study was to evaluate the diagnostic concordance characteristics of oral cavity lesions by comparing the clinical diagnosis of the lesions with the histopathologic diagnosis. Material and Method. A retrospective analysis was conducted on the patients, who were admitted with oral cavity pathology and underwent biopsy procedure between 2007 and 2011. The oral cavity lesions were classified into 6 different groups as odontogenic cysts, nonodontogenic cysts, odontog...

  10. Differential diagnosis of bilateral thalamic lesions

    International Nuclear Information System (INIS)

    A multitude of different diseases can result in bilateral thalamic lesions. These include vascular pathologies requiring prompt therapeutic intervention, such as basilar thrombosis or thrombosis of the internal cerebral veins, as well as tumors, infectious or demyelinating diseases, and toxic-metabolic lesions. Therefore, detailed knowledge of the typical radiological findings for the various diseases is essential for determining the correct diagnosis. This review provides a synopsis of the radiological findings for the most important bithalamic lesions and an overview of the literature

  11. MR imaging of sacral and perisacral lesions

    International Nuclear Information System (INIS)

    This exhibit demonstrates the utility of MR imaging in evaluating sacral and perisacral lesions. Thirty-two lesions were studied using a superconducting 1.0-T MR imager. Eleven primary and 13 metastatic tumors, four congenital lesions, and four arachnoid cysts were evaluated. MR did not usually enable a more specific histologic diagnosis than other imaging techniques. However, extraosseous and proximal spinal extent of tumors was well defined without use of oral or intravenous contrast material. MR imaging is an excellent noninvasive technique for evaluating most sacral and perisacral lesions and is particularly helpful when precise tumor extent must be determined for treatment planning

  12. Tumour-like lesions in multiple sclerosis.

    Science.gov (United States)

    Jamroz-Wi?niewska, Anna; Janczarek, Marzena; Belniak, Ewa; Stelmasiak, Zbigniew; Bartosik-Psujek, Halina

    2008-01-01

    The presence of tumefactive lesions on magnetic resonance imaging (MRI) in multiple sclerosis (MS) patients can cause diagnostic difficulties. It requires differential diagnosis between tumefactive demyelinating lesion (TDL) and the coexistence of neoplasm; it also implies further management. The precise assessment of such lesions at the first clinical manifestation of the disease is particularly important. We present three cases of MS presenting with tumour-like lesions of the brain. Based on serial MRI studies, stereotactic biopsy and the response to treatment with corticosteroids, the diagnosis of TDL was established in every case. PMID:18512174

  13. Subcategorization of MS lesions by MR imaging

    International Nuclear Information System (INIS)

    MR imaging is known to be highly sensitive to multiple sclerosis (MS)-induced cerebral lesions. The contribution of MR imaging in distinguishing lesions with differing histologic characteristics is less clear. The purpose of this study was to determine if MR imaging could be used to sort ''plaque'' populations. MS lesions from 60 patients with definite MS were studied at 1.5 T.T1 and T2 values were prolonged in the majority of lesions in patients with relatively quiescent or slowly progressive disease. This group of lesions included most ventricle angle lesions, and periventricular lesions which were remarkably stable on serial examination. In two of six patients with ''acute flares'' of disease studied by serial MR imaging examinations over a 6-month period, lesions with apparently longer T1 and moderately prolonged T2 correlated with clinically evolving disease. T2-weighted imaging alone was not discriminating. Although these are preliminary results, they suggest some MR imaging potential for lesion discrimination which can be tested by serial examination studies

  14. Thermophysical lesions caused by HZE particles

    International Nuclear Information System (INIS)

    This paper deals with a type of damage caused by heavy particles that may occur in subcellular structures. These lesions are called thermophysical radiation injury and are similar to damage produced in solids by HZE particles. This chapter summarizes some of the experimental evidence for the presence of these lesions in certain mammalian tissues including the retina, brain, cornea, lens of mice and seeds of corn. Of all tissues examined, only the cornea exhibited a type of lesion which would fulfill the criteria of thermophysical lesions

  15. Multispectral near-IR reflectance imaging of simulated early occlusal lesions: Variation of lesion contrast with lesion depth and severity

    Science.gov (United States)

    Simon, Jacob C.; Chan, Kenneth H.; Darling, Cynthia L.; Fried, Daniel

    2014-01-01

    Background and Objectives Early demineralization appears with high contrast at near-IR wavelengths due to a ten to twenty fold difference in the magnitude of light scattering between sound and demineralized enamel. Water absorption in the near-IR has a significant effect on the lesion contrast and the highest contrast has been measured in spectral regions with higher water absorption. The purpose of this study was to determine how the lesion contrast changes with lesion severity and depth for different spectral regions in the near-IR and compare that range of contrast with visible reflectance and fluorescence. Materials and Methods Forty-four human molars were used in this in vitro study. Teeth were painted with an acid-resistant varnish, leaving a 4×4 mm window on the occlusal surface of each tooth exposed for demineralization. Artificial lesions were produced in the unprotected windows after 12–48 hr exposure to a demineralizing solution at pH-4.5. Near-IR reflectance images were acquired over several near-IR spectral distributions, visible light reflectance, and fluorescence with 405-nm excitation and detection at wavelengths greater than 500-nm. Crossed polarizers were used for reflectance measurements to reduce interference from specular reflectance. Cross polarization optical coherence tomography (CP-OCT) was used to non-destructively assess the depth and severity of demineralization in each sample window. Matching two dimensional CP-OCT images of the lesion depth and integrated reflectivity were compared with the reflectance and fluorescence images to determine how accurately the variation in the lesion contrast represents the variation in the lesion severity. Results Artificial lesions appear more uniform on tooth surfaces exposed to an acid challenge at visible wavelengths than they do in the near-IR. Measurements of the lesion depth and severity using CP-OCT show that the lesion severity varies markedly across the sample windows and that the lesion contrast in the visible does not accurately reflect the large variation in the lesion severity. Reflectance measurements at certain near-IR wavelengths more accurately reflect variation in the depth and severity of the lesions. Conclusion The results of the study suggest that near-IR reflectance measurements at longer wavelengths coincident with higher water absorption are better suited for imaging early caries lesions. PMID:24375543

  16. Radiological features of excavated pulmonary tumoral lesions

    International Nuclear Information System (INIS)

    The clinical and radiological features of 43 cases of primitive and metastatic excavated pulmonary tumoral lesions are analysed. The clinical signs and ssymptoms, sex, color, habits of life, histologic classification of the excavated primitive and metastatic lesions, size and thickness of the excavated tumoral nodules and their roentgenographic characteristics are studied. (Author)

  17. Inter- and intra-observer variability associated with the use of the Mirels' scoring system for metastatic bone lesions.

    LENUS (Irish Health Repository)

    Mac Niocaill, Ruairi F

    2011-01-01

    Metastatic bone disease is increasing in association with ever-improving medical management of osteophylic malignant conditions. The precise timing of surgical intervention for secondary lesions in long bones can be difficult to determine. This paper aims to evaluate a classic scoring system. All radiographs were examined twice by three orthopaedic oncologists and scored according to the Mirels\\' scoring system. The Kappa statistic was used for the purpose of statistical analysis. The results show agreement between observers (??=?0.35-0.61) for overall scores at the two time intervals. Inter-observer agreement was also seen with subset analysis of size (??=?0.27-0.60), site (??=?0.77-1.0) and nature of the lesion (??=?0.55-0.81). Similarly, low levels of intra-observer variability were noted for each of the three surgeons (?=?0.34, 0.39, and 0.78, respectively). These results indicate a reliable, repeatable assessment of bony metastases. We continue to advocate its use in the management of patients with long bone metastases.

  18. Evaluation of hepatic cystic lesions

    Directory of Open Access Journals (Sweden)

    Marten A Lantinga

    2013-01-01

    Full Text Available Hepatic cysts are increasingly found as a mere coincidence on abdominal imaging techniques, such as ultrasonography (USG, computed tomography (CT and magnetic resonance imaging (MRI. These cysts often present a diagnostic challenge. Therefore, we performed a review of the recent literature and developed an evidence-based diagnostic algorithm to guide clinicians in characterising these lesions. Simple cysts are the most common cystic liver disease, and diagnosis is based on typical USG characteristics. Serodiagnostic tests and microbubble contrast-enhanced ultrasound (CEUS are invaluable in differentiating complicated cysts, echinococcosis and cystadenoma/cystadenocarcinoma when USG, CT and MRI show ambiguous findings. Therefore, serodiagnostic tests and CEUS reduce the need for invasive procedures. Polycystic liver disease (PLD is arbitrarily defined as the presence of > 20 liver cysts and can present as two distinct genetic disorders: autosomal dominant polycystic kidney disease (ADPKD and autosomal dominant polycystic liver disease (PCLD. Although genetic testing for ADPKD and PCLD is possible, it is rarely performed because it does not affect the therapeutic management of PLD. USG screening of the liver and both kidneys combined with extensive family history taking are the cornerstone of diagnostic decision making in PLD. In conclusion, an amalgamation of these recent advances results in a diagnostic algorithm that facilitates evidence-based clinical decision making.

  19. Evaluation of hepatic cystic lesions.

    Science.gov (United States)

    Lantinga, Marten A; Gevers, Tom J G; Drenth, Joost P H

    2013-06-21

    Hepatic cysts are increasingly found as a mere coincidence on abdominal imaging techniques, such as ultrasonography (USG), computed tomography (CT) and magnetic resonance imaging (MRI). These cysts often present a diagnostic challenge. Therefore, we performed a review of the recent literature and developed an evidence-based diagnostic algorithm to guide clinicians in characterising these lesions. Simple cysts are the most common cystic liver disease, and diagnosis is based on typical USG characteristics. Serodiagnostic tests and microbubble contrast-enhanced ultrasound (CEUS) are invaluable in differentiating complicated cysts, echinococcosis and cystadenoma/cystadenocarcinoma when USG, CT and MRI show ambiguous findings. Therefore, serodiagnostic tests and CEUS reduce the need for invasive procedures. Polycystic liver disease (PLD) is arbitrarily defined as the presence of > 20 liver cysts and can present as two distinct genetic disorders: autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (PCLD). Although genetic testing for ADPKD and PCLD is possible, it is rarely performed because it does not affect the therapeutic management of PLD. USG screening of the liver and both kidneys combined with extensive family history taking are the cornerstone of diagnostic decision making in PLD. In conclusion, an amalgamation of these recent advances results in a diagnostic algorithm that facilitates evidence-based clinical decision making. PMID:23801855

  20. A clinicopathologic study of excised conjunctival lesions

    Directory of Open Access Journals (Sweden)

    Mohamad Elshazly Laila

    2011-01-01

    Full Text Available Purpose : This study was aimed at to determine the frequency of excised conjunctival lesions in a patient population treated over a 10-year period. Materials and Methods : The data of all excised conjunctival lesions with tissue diagnoses from 1998 to 2008 in the pathology department were analyzed. Results : The patient group comprised 192 conjunctival specimens; 106 (55.2% obtained from male patients and 86 (44.8 % from female patients. The age range was 75 years with a mean age of 27.07 ± 17 years. The most frequent excised lesions were pyogenic granulomas, which represented 30.7% (59 cases. Pigmented epithelial tumors were the second most common benign conjunctival lesions (44 cases, 22.9%. Out of these cases, compound nevus represented 86.4% (38 cases and junctional nevus represented 6.8% (3 cases. Primary acquired melanosis and subepithelial nevus were reported in two cases (4.5% and one case (2.3%, respectively. Cystic lesions represented 12% (23 cases. These were mostly ductal retention cysts in 16 cases (70%, occupying the fornix in eight cases. Ocular surface squamous neoplasia (OSSN was detected in 21 cases (10.9% significantly affecting an older age group as compared to other lesions (mean age 45.9 ± 16.7. Other less frequent lesions included papilloma (10 cases, 2.5%, dermolipoma (8 cases, 4.2%, solid dermoid (3 cases, 1.6%, hemangioma (15 cases, 7.8%, and benign reactive lymphoid hyperplasia (four cases, 2.1%. Conclusion : Benign lesions were the most frequent histologically diagnosed conjunctival lesions. The true malignant lesions were lower than what has been described in many reports. The significant proportion of precancerous OSSN can be attributed to sun exposure and ultraviolet light in Egypt.

  1. Lesion processing: high-fidelity versus lesion-bypass DNA polymerases

    OpenAIRE

    Broyde, Suse; Wang, Lihua; Rechkoblit, Olga; Geacintov, Nicholas E.; Patel, Dinshaw J.

    2008-01-01

    When a high-fidelity DNA polymerase encounters certain DNA-damage sites, its progress can be stalled and one or more lesion-bypass polymerases are recruited to transit the lesion. Here, we consider two representative types of lesions: (i) 7,8-dihydro-8-oxogua-nine (8-oxoG), a small, highly prevalent lesion caused by oxidative damage; and (ii) bulky lesions derived from the environmental pre-carcinogen benzo[a]pyrene, in the high-fidelity DNA polymerase Bacillus fragment (BF) from Bacillus ste...

  2. Tumors and tumor-like lesions of the jaw mixed and radiopaque lesions.

    Science.gov (United States)

    Bernaerts, A; Vanhoenacker, F M; Hintjens, J; Chapelle, K; Salgado, R; De Foer, B; De Schepper, A M

    2006-01-01

    Radiopaque lesions and lesions of mixed radioopacity are far less frequent than their radiolucent counterparts. Included in this spectrum are infectious and metastatic disease, inherited and developmental disorders and rare tumoral lesions. This article deals with the imaging features that may assist in the (differential) diagnosis of these lesions. in many instances, the radiological characterization is typical (osteoma, enostoma, fibrous dysplasia, Paget disease...), obviating the need for further invasive histological confirmation. Other lesions may share overlapping clinical, radiological and pathological features. In these cases, correlation of histopathological diagnosis with clinical findings and imaging features is of utmost importance for a correct diagnosis. PMID:16729446

  3. Essential, trace and toxic element concentrations in the liver of the world’s largest bony fish, the ocean sunfish (Mola mola)

    International Nuclear Information System (INIS)

    Highlights: • Documented concentrations of 21 elements in the liver of an ocean sunfish. • Toxic element concentrations were generally low compared to essential elements. • Ca and Fe concentrations were elevated and suggestive of Ca and Fe toxicity. • Cd was the highest of the toxic elements and ranked 8th among all elements. - Abstract: No studies document essential (calcium, magnesium, phosphorus, potassium, sodium), trace (barium, boron, chromium, cobalt, copper, iron, manganese, molybdenum, selenium, zinc) or toxic element (antimony, arsenic, cadmium, lead, mercury, thallium) concentrations in any members of the family Molidae, including the world’s largest bony fish, the ocean sunfish (Mola mola). Here, we analyzed 21 elements in the liver of one M. mola. These values were compared to liver concentrations in multiple species with spatial and dietary overlap. Concentrations of calcium (3339 ppm wet weight) and iron (2311 ppm wet weight) were extremely elevated in comparison to a number of other fish species, indicating that calcium and/or iron toxicity may have occurred in this animal. Concentrations of toxic elements were generally low, with the exception of cadmium (3.5 ppm). This study represents the first report of essential, trace and toxic elements in this species

  4. Utilization of cone beam CT for reconstruction of dose distribution delivered in image-guided radiotherapy of prostate carcinoma - bony landmark setup compared to fiducial markers setup.

    Science.gov (United States)

    Paluska, Petr; Hanus, Josef; Sefrova, Jana; Rouskova, Lucie; Grepl, Jakub; Jansa, Jan; Kasaova, Linda; Hodek, Miroslav; Zouhar, Milan; Vosmik, Milan; Petera, Jiri

    2013-01-01

    The purpose of this study was to compare two different styles of prostate IGRT: bony landmark (BL) setup vs. fiducial markers (FM) setup. Twenty-nine prostate patients were treated with daily BL setup and 30 patients with daily FM setup. Delivered dose distribution was reconstructed on cone-beam CT (CBCT) acquired once a week immediately after the alignment. Target dose coverage was evaluated by the proportion of the CTV encompassed by the 95% isodose. Original plans employed 1 cm safety margin. Alternative plans assuming smaller 7 mm margin between CTV and PTV were evaluated in the same way. Rectal and bladder volumes were compared with initial ones. While the margin reduction in case of BL setup makes the prostate coverage significantly worse (p = 0.0003, McNemar's test), in case of FM setup with the reduced 7 mm margin, the prostate coverage is even better compared to BL setup with 10 mm margin (p = 0.049, Fisher's exact test). Moreover, partial volumes of organs at risk irradiated with a specific dose can be significantly lowered (p < 0.0001, unpaired t-test). Reducing of safety margin is not acceptable in case of BL setup, while the margin can be lowered from 10 mm to 7 mm in case of FM setup. PMID:23652250

  5. Approach to cystic lesions of the pancreas.

    Science.gov (United States)

    Schmid, Roland M; Siveke, Jens T

    2014-02-01

    Cystic lesions of the pancreas are detected more frequently due to the improvement of imaging technologies. Their prevalence increases with age. In 95?% of cases, the spectrum of cystic neoplasia includes intraductal papillary mucinous neoplasia (IPMN), mucinous cystic neoplasia (MCN), serous cystic neoplasia, and solid pseudopapillary neoplasia (SPN). Diagnostic procedures aim to distinguish between neoplastic cystic and non-neoplastic cystic lesions as well as serous and mucinous lesions because of their different malignant potential. In most cases,cystic lesions are detected incidentally by computed tomography and magnetic resonance imaging (MRI) performed for other reasons. In our opinion, MRI/magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasound (EUS) are complementary diagnostic procedures. In doubtful cases, cyst fluid analysis might be performed. The most frequent lesions are IPMNs. MRI/MRCP allows the detection of the number of cystic lesions, the relation to the main pancreatic duct, and the size of the lesion. EUS is superior to evaluate mural nodules. The relation to the main pancreatic duct can more easily appreciated with secretin MRI, MCN, SPN as well as main-duct type IPMN and BD-IPMN with "high-risk stigmata" for malignancy should be resected. Asymptomatic BD-IPMN without mural nodules, no main duct involvement, and a size less than 30 mm can be followed with a watchful waiting strategy. PMID:24254128

  6. MRI examination on microcalcification lesions on mammography

    International Nuclear Information System (INIS)

    With a recent increase of patients who are pointed out microcalcification on mammography (MMG) but otherwise normal, we have increasingly difficulties in making diagnosis. In this paper we examined magnetic resonance imaging (MRI) findings and diagnosis of microcalcification lesions. Out of consecutive patients who visited our hospital for close exploration of calcification on MMG from July 2006 to March 2009, 124 patients who were performed MRI were enrolled in this study. The morphology and enhancement kinetics of their lesions visualized by MRI were classified with reference to the breast imaging reporting and data system (BIRADS)-MRI and were compared with outcomes of histological diagnoses. As a result, all lesions in which no abnormal enhancement was seen on MRI were benign. Malignant lesions accounted for about 80.0% in mass patterns, and about more than half in non-mass like enhancement. About 30% of the lesions were malignant in the Focus/Foci pattern which designates lesions with the size of less than 5 mm. MRI is capable of predicting whether the microcalcification lesion is malignant or benign in some degree in patients with positive findings, and we can omit Stereotactic Mammotome biopsy (ST-MTB) in those with negative findings. Accordingly MRI is considered to be an extremely useful modality. (author)

  7. Lesion localization in aphasia without hemiparesis

    International Nuclear Information System (INIS)

    The distribution of the lesions responsible for aphasia unassociated with right-sided hemiparesis was evaluated by cranial computed tomography (CT) among stroke patients. In the Broca aphasia group were observed atypical aphasic symptoms, and the lesions were far more localized than in ordinary Broca one. In the Wernicke aphasia group showed relatively large lesions in the left superior temporal gyrus, sometimes extending to supramarginal and angular gyri, which caused such additional symptoms as apraxia without motor paresis in some cases. In the Transcortical motor aphasia group showed the occlusion of the left internal carotid artery, though without obvious abnormality at CT. In another patient a circumscribed low density lesion was disclosed in the area anterior and superior to so-called Broca's area. In the Transcortical sensory aphasia group, the lesion involved the borderzone supplied by the left middle and posterior cerebral arteries. In the Amnestic aphasia group showed a lesion in the left parietal lobe, while in another no remarkable change was demonstrated. In the Global aphasia group, one had multiple isolated lesions in both anterior and posterior speech areas. Another showed a large lesion involving the whole territory of the left middle cerebral artery. In the remaining one a high density area was observed in the left superior temporal, supramarginal and angular gyri, not extending to the frontal lobe beyond with sylvian fissure. Therefore, in interpreth sylvian fissure. Therefore, in interpreting CTs of such aphasic patients we must take account of not only the extent of the lesion but also the severity of destruction. (J.P.N.)

  8. Recognizing upper-extremity stress lesions.

    Science.gov (United States)

    Cervoni, T D; Martire, J R; Curl, L A; McFarland, E G

    1997-08-01

    Athletes in sports such as baseball, gymnastics, weight lifting, javelin, and racket sports are susceptible to stress lesions in the bones of the upper extremities. Injuries range from periostitis to bone spurs to stress fractures. Injuries in adolescents typically involve the growth plates, while midshaft injuries at the area of muscle insertion are more common in adults. It's especially important to detect these injuries in adolescents because untreated stress lesions at growth plates can have serious consequences. Plain films demonstrate obvious fractures and physeal injuries, but triple-phase bone scans are often needed to define the extent of stress lesions. PMID:20086928

  9. Macromolecular lesions and cellular radiation chemistry

    International Nuclear Information System (INIS)

    Our studies of the interaction of densely ionizing particles with macromolecules in the living cell may be divided into four parts: characterization of lesions to cellular DNA in the unmodified Bragg ionization curve; characterization of lesions to cellular DNA in the spread Bragg curve as used in radiation therapy; elucidation of the cellular radiation chemistry characteristic of high vs. low LET radiation qualities; and the introduction of novel techniques designed to give a better understanding of the fundamental properties of induction of lesions and their repair potentials in high LET radiation

  10. Imaging of nontraumatic benign splenic lesions

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jin Young; Kim, Eun Kyung; Chung, Jae Joon; Kim, Myeong Jin; Lee, Jong Tae; Yoo, Hyung Sik; Kim, Seong Joon [Yonsei Univ. College of Medicine Research Institute of Radiological Science, Seoul (Korea, Republic of); Kim, Lu Ci A [Yonsei Univ. College of Medicine, Seoul (Korea, Republic of)

    1999-04-01

    The spleen is one of the largest organ in the reticuloendothelial system and plays an important role in the activation of immune response. It is the organ most commonly injured after blunt abdominal trauma, and malignant lesions such as lymphoma, or these due to metastasis, occur not infrequently. Even so, it is ignored even in abdominal ultrasonography. Some benign splenic lesions, however can cause severe symptoms and result in high mortality, and their accurate diagnosis is therefore essential. This study describes the imaging findings and histopathologic features of various nontraumatic benign splenic lesions.

  11. Acquired CNS lesions in fetal MRI

    International Nuclear Information System (INIS)

    Acquired central nervous system (CNS) lesions are often subtle; therefore, the prenatal diagnosis of these lesions is extremely important. The fetal ultrasound examination and magnetic resonance imaging (MRI) are two important imaging methods that give an insight into these types lesions. The method of choice during pregnancy is still fetal ultrasound; however, fetal MRI is important when there are certain pathologies, e.g. periventricular leukomalacia (PVL) or malformations of the vein of Galen. In this manner clinicians can plan further therapy after childbirth in advance (e.g. cerebral angiography or embolization). (orig.)

  12. Quantitative scintigraphic study of 1300 brain lesions

    International Nuclear Information System (INIS)

    A quantitative method has been developed to study sequential scintigraphs carried out during the 6 hours following technetium 99m injection. Its contribution to the diagnosis of brain lesion types is reported. The variation in the ratio R = count rate opposite the lesion / count rate opposite the healthy brain as a function of the time following injection of sup(99m)Tc pertechnetate is given for the 4-mains types of spreading intracranial lesions: meningiomas, glioblastomas, astrocytomas, metastases. It is observed that R decreases continuously for meningiomas and increases continuously for the other three kinds of tumour

  13. FDG-PET in infectious lesions. The detection and assessment of lesion activity

    International Nuclear Information System (INIS)

    The usefulness of FDG-PET in the detection of infectious foci and the assessment of lesion activity was evaluated. The study covered 24 patients with 25 FDG-PET studies, including lesions of bacterial, tuberculous and fungal origins. The FDG uptake was determined by the lesion to muscle ratio (LMR) on the static images. The time activity curves (TACs) were classified into four patterns based on both the existence of an initial peak and a slope thereafter. A high FDG uptake was observed in 23 of 25 lesions (92%). Two lesions, in which no abnormal uptake was noted, included one in the healing stage and the other consisting of a cavity with a thin wall. The acute active lesions showed higher LMRs than the chronic active or healing lesions (mean±SD: 9.8±3.6, 3.6±1.8 and 4.3±1.7, respectively, p<0.05), and they could be approximately distinguished by an LMR of 6. The patterns of the TACs in acute or chronic active lesions were either an increase without an initial peak or a plateau, while those in the healing lesions demonstrated predominantly an increase with an initial sharp peak. Our results indicated that FDG-PET is clinically useful in the detection of the infection of miscellaneous microorganisms as well as in the assessment of lesion activity. (author)

  14. Disseminated superficial actinic porokeratosis with hyperkeratotic lesions.

    Science.gov (United States)

    Schuldenfrei, J A; Fix, L W

    1984-04-01

    A patient with disseminated superficial actinic porokeratosis (DSAP) presented with unusual exudative hyperkeratotic plaques in addition to lesions more typical of the disease. The plaques were unresponsive to various systemic antibiotics, but responded dramatically to systemic corticosteroid therapy. PMID:6723369

  15. Approximate Lesion Localization in Dermoscopy Images

    CERN Document Server

    Celebi, M Emre; Schaefer, Gerald; Stoecker, William V; 10.1111/j.1600-0846.2009.00357.x

    2010-01-01

    Background: Dermoscopy is one of the major imaging modalities used in the diagnosis of melanoma and other pigmented skin lesions. Due to the difficulty and subjectivity of human interpretation, automated analysis of dermoscopy images has become an important research area. Border detection is often the first step in this analysis. Methods: In this article, we present an approximate lesion localization method that serves as a preprocessing step for detecting borders in dermoscopy images. In this method, first the black frame around the image is removed using an iterative algorithm. The approximate location of the lesion is then determined using an ensemble of thresholding algorithms. Results: The method is tested on a set of 428 dermoscopy images. The localization error is quantified by a metric that uses dermatologist determined borders as the ground truth. Conclusion: The results demonstrate that the method presented here achieves both fast and accurate localization of lesions in dermoscopy images.

  16. Basic dermoscopy of melanocytic lesions for beginners

    Directory of Open Access Journals (Sweden)

    Gra?yna Kami?ska-Winciorek

    2011-08-01

    Full Text Available Background. Dermoscopy is a safe, easy-to-repeat diagnostic method used especially in the diagnosis of melanocytic lesions and others. Performing dermoscopy for skin lesions on the whole body takes only one minute more than standard clinical examination. Therefore the knowledge of basic dermoscopy among multi-specialization doctors – from general practitioners, surgeons, oncologists to dermatologists – increases the possibility of detection of potential melanoma.Aim. To describe the basic aspects of dermoscopy of melanocytic lesions.Methods. Review of medical databases PubMed and Medline from the last 8 years and a retrospective analysis of own experience.Results. We report the fundamental principles of performing dermoscopy, basic dermoscopic features and diagnostic algorithms of selected melanocytic lesions. Conclusions. The knowledge base of dermoscopy is very important among doctors of many specializations. It increases melanoma detection in very early stages.

  17. Keloidal granuloma faciale with extrafacial lesions

    Directory of Open Access Journals (Sweden)

    Verma Rajesh

    2005-01-01

    Full Text Available Granuloma faciale (GF is a rare cutaneous disorder characterized by one to several soft, erythematous to livid papules, plaques or nodules, usually occurring on the face. Extrafacial lesions are uncommon. A 52-year-old lady with multiple asymptomatic, variously sized brownish-black colored, firm, sharply circumscribed plaques resembling keloids on both cheeks and extrafacial lesions on the right arm and the right breast is presented for its unusual keloidal appearance and typical histopathological findings. She failed to respond to oral dapsone 100 mg daily administered for 3 months. Local infiltration of triamcinolone combined with cryotherapy led to only partial flattening of the lesions. All the skin lesions were excised surgically followed by flap transfer grafting on both cheeks. The cosmetic outcome was highly satisfactory.

  18. Focal hepatic lesions: Differential diagnosis with MRI

    International Nuclear Information System (INIS)

    Differentiation between benign and malignant hepatic lesions was attempted according to the shape of the lesion, internal architecture and characteristic of signal intensity on MR images. We retrospectively analyzed 20 cases of hemangiomas, 12 cases of hepatomas and 5 cases of cysts which were diagnosed by clinical, radiological and surgical methods (33 patients). On T1-weighted, porton weighted, and T2-weighted images, most hemangiomas (70%) and cysts (100%) had smooth margin and were round or oval in shape, while hepatocellular carcinomas had irregular (67%) or lobulated (33%) borders. Ninety percent of hemangiomas and 100% of cysts had homogeneous signal intensity, but 67% of hepatocellular carcinomas were inhomogeneous. Signal intensities of hepatocellular carcinomas were more variable. However, hemangiomas were isointense or hyperintense on proton weighted images, and markedly hyperintense on T2-weighted images. In conclusion, inhomogeneous, irregular border, and variable signal intensity lesions had a high likelihood of malignancy, while homogeneous and markedly hyperintense lesions were more likely benign

  19. Repair and recovery of biological radiation lesions

    International Nuclear Information System (INIS)

    When living cells are irradiated with ionizing particles, two types of radiation lesions are produced: reparable and irreparable. Cell survival curves with complete repair are presented for pion peak, plateau and mixed irradiations. (Auth.)

  20. CT evaluation of right colonic wall lesions

    Energy Technology Data Exchange (ETDEWEB)

    Gossios, K.J. [Dept. of Computed Tomography, General Hospital of Ioannina (Greece); Tsianos, E.V. [Dept. of Internal Medicine, School of Medicine, Univ. of Ioannina (Greece); Tsimoyiannis, E.C. [Dept. of Surgery, General Hospital of Ioannina (Greece)

    1994-08-01

    CT of the entire clean colon after a tap water enema with intravenous injection of contrast medium was performed in 20 patients with a diagnosis of caecal and ascending colonic lesions at barium enema studies or colonoscopy. Histological proof was obtained by endoscopy or at surgery in all cases. Using this ``water technique`` we were able to detect the wall abnormalities and describe their CT features in relation to the histological findings. We found that asymmetric thickening of the bowel wall, an irregular and lobulated inner and outer contour and/or a focal soft tissue mass usually exceeding 2 cm from the luminal to serosal surface were very helpful findings for a malignant lesion but not the hallmark of malignancy. The CT appearance of the extraluminal part of the lesion was most helpful in differentiating between benign and malignant lesions. (orig.)

  1. CT evaluation of right colonic wall lesions

    International Nuclear Information System (INIS)

    CT of the entire clean colon after a tap water enema with intravenous injection of contrast medium was performed in 20 patients with a diagnosis of caecal and ascending colonic lesions at barium enema studies or colonoscopy. Histological proof was obtained by endoscopy or at surgery in all cases. Using this ''water technique'' we were able to detect the wall abnormalities and describe their CT features in relation to the histological findings. We found that asymmetric thickening of the bowel wall, an irregular and lobulated inner and outer contour and/or a focal soft tissue mass usually exceeding 2 cm from the luminal to serosal surface were very helpful findings for a malignant lesion but not the hallmark of malignancy. The CT appearance of the extraluminal part of the lesion was most helpful in differentiating between benign and malignant lesions. (orig.)

  2. Post-mortal lesions in freshwater environment.

    Science.gov (United States)

    Vanin, Stefano; Zancaner, Silvano

    2011-10-10

    Postmortem animal feeding activity may cause considerable damage to bodies resulting in the modification of wounds, loss of identifying features and injury. Certain postmortem lesions may appear inflicted or non-inflicted antemortem injuries. At present, apart from cases in sea water, no data are available about post mortal lesions performed by aquatic organisms. This note that represents the first report concerning colonisation of a dead body by crustaceans a few hours after death, describes injuries caused by the amphipod Niphargus elegans on the face, and in particular on the eye region, of a young man dead by drowning. The lesions recorded in this case are comparable with the lesions caused by ants. The high plasticity in the food choice can allow Amphipoda to colonise drowning bodies in every moment after dead, however the benthonic behaviour of these animals suggests a more important role in the colonisation during post-mortem submersion periods. PMID:21708437

  3. Lesions in the external auditory canal.

    Science.gov (United States)

    Chatra, Priyank S

    2011-10-01

    The external auditory canal is an S- shaped osseo-cartilaginous structure that extends from the auricle to the tympanic membrane. Congenital, inflammatory, neoplastic, and traumatic lesions can affect the EAC. High-resolution CT is well suited for the evaluation of the temporal bone, which has a complex anatomy with multiple small structures. In this study, we describe the various lesions affecting the EAC. PMID:22223939

  4. Lesions in the external auditory canal

    OpenAIRE

    Chatra, Priyank S.

    2011-01-01

    The external auditory canal is an S- shaped osseo-cartilaginous structure that extends from the auricle to the tympanic membrane. Congenital, inflammatory, neoplastic, and traumatic lesions can affect the EAC. High-resolution CT is well suited for the evaluation of the temporal bone, which has a complex anatomy with multiple small structures. In this study, we describe the various lesions affecting the EAC.

  5. Cystic lesions of the seminal vesicles

    International Nuclear Information System (INIS)

    Between October 1990 and March 1991, 8 patients with cystic lesions in the region of the posterior bladder wall, the seminal vesicles and the prostate were examined by MRI. In all cases there was accurate characterisation of the lesion and of its anatomy. In 3 patients with abnormalities in the retrovesical space there was very good agreement with the operative findings. 4 patients were treated conservatively. In these patients there was good agreement with the findings on cystoscopy, CT and sonography. (orig.)

  6. Traumatic kidney injury; Lesions traumatiques du rein

    Energy Technology Data Exchange (ETDEWEB)

    Bellin, M.F.; Coumbaras, J. [Centre Hospitalier Universitaire Paul-Brousse, 94 - Villejuif (France). Service de radiologie; Vasile, M.; Akakpo, J.P.; Grenier, PH. [Centre Hospitalier Universitaire Pitie-Salpetriere, 75 - Paris (France). Service de radiologie polyvalente diagnostique et interventionnelle; Lebleu, L

    2001-02-01

    Radiology is a major exploration tool for assessing kidney injury. Helical computed tomography is useful to detect parenchymal lesion and urinary leakage. Ultrasonography can show the renal morphology and is useful for follow-up. CT and/or angiography is used to detect vascular lesions. Imaging is essential for precise assessment of the severity of traumatic kidney injury, of the function of the contralateral kidney, and for follow-up. (authors)

  7. “Nora lesion” – Bizarre parosteal osteochondromatous proliferation

    OpenAIRE

    Mahajan, Sumit; Chandra, Rajesh; Mohan Lal, Yash

    2012-01-01

    Nora lesion is a rare benign parosteal osteochondromatous proliferation involving feet and hand. Aggressive features on imaging and confusing results on histopathological studies make its diagnosis difficult. Since the time of its discovery, only few cases have been reported in the literature. Authors report a case of Nora's lesion on the planto-medial aspect of metatarsal head of great toe of left foot. The diagnosis was suspected by imaging characteristic features and was confirmed by histo...

  8. Quantitative physiology and immunohistochemistry of oral lesions

    OpenAIRE

    Lee, Li-tzu; Chen, Po-hsiung; Chang, Chiou-tuz; Wang, John; Wong, Yong-kie; Wang, Hsing-wen

    2013-01-01

    Angiogenesis and hypoxia are reported to correlate with tumor aggressiveness. In this study, we investigated the potential of optically measured total hemoglobin concentration (THC) and blood oxygen saturation (StO2) as a quantitative measure of angiogenesis and hypoxia in oral lesions with an immunohistochemical comparison. 12 normal subjects and 40 oral patients (22 oral squamous cell carcinoma (SCC), 18 benign/premalignant lesions including 11 verrucous hyperplasia (VH) and 7 hyperkeratosi...

  9. Polypoid uterine lesions mimicking endometrial stromal sarcoma.

    OpenAIRE

    Mccluggage, W. G.; Alderdice, J. M.; Walsh, M. Y.

    1999-01-01

    Two polypoid submucosal uterine lesions were examined histologically and immunohistochemically with monoclonal antibodies to desmin and alpha smooth muscle actin. One case comprised a leiomyoma and the other a polypoid form of adenomyosis. Both polyps had prolapsed through the external cervical os. The lesions had an ulcerated surface with focal areas of marked increased cellularity and pronounced vascularity throughout, such that they mimicked a low grade endometrial stromal sarcoma infiltra...

  10. Percutaneous acetabuloplasty for metastatic acetabular lesions

    OpenAIRE

    Logroscino Giandomenico; Waide Victor; Rossi Barbara; Muratori Francesco; Milani Alessandro; Scaramuzzo Laura; Liuzza Francesco; Maccauro Giulio; Logroscino Carlo A; Maffulli Nicola

    2008-01-01

    Abstract Background Osteolytic metastases around the acetabulum are frequent in tumour patients, and may cause intense and drug-resistant pain of the hip. These lesions also cause structural weakening of the pelvis, limping, and poor quality of life. Percutaneous acetabuloplasty is a mini-invasive procedure for the management of metastatic lesions due to carcinoma of the acetabulum performed in patients who cannot tolerate major surgery, or in patients towards whom radiotherapy had already pr...

  11. Focal lesions in the central nervous system

    International Nuclear Information System (INIS)

    This report reviews the animal and human studies currently in progress at LBL with heavy-ion beams to induce focal lesions in the central nervous system, and discusses the potential future prospects of fundamental and applied brain research with heavy-ion beams. Methods are being developed for producing discrete focal lesions in the central nervous system using the Bragg ionization peak to investigate nerve pathways and neuroendocrine responses, and for treating pathological disorders of the brain

  12. Bony landmarks are not an adequate substitute for lymphangiography in defining pelvic lymph node location for the treatment of cervical cancer with radiotherapy

    International Nuclear Information System (INIS)

    Purpose: Curative radiotherapy (RT) for carcinoma of the cervix requires adequate irradiation of regional lymph node groups. The best nonsurgical method of defining lymph node anatomy in the pelvis remains the lymphangiogram (LAG). This study was designed to determine if bony landmarks could accurately substitute for LAG as a means of determining lymph node position for the purpose of pelvic RT treatment planning. Methods and Materials: The post-LAG simulation films of 22 patients treated at the Fox Chase Cancer Center for cervical cancer were examined. On anterior/posterior (A/P) simulation films, the distance of lymph nodes was determined from the top, middle, and bottom of the sacroiliac joint, and at the pelvic rim, 1 and 2 cm above the acetabulum. On lateral (LAT) simulation films, lymph node position was measured at points 0, 4, and 8 cm along a line from the bottom of L5 to the anterior aspect of the pubic symphysis. Positive values represent lateral and anterior distances relative to the reference point on A/P and LAT films, respectively. Negative values represent distances in the opposite direction. The adequacy of standard pelvic fields as defined by the Gynecologic Oncology Group (GOG) (A/P: 1.5 cm margin on the pelvic rim; LAT field edge is a vertical line anterior to the pubic symphysis) was also examined. Data are expressed as the mean ± two standard deviations, (i.e. 95% confidence level). Results: On A/P simulation films, the distance of visualized lytion films, the distance of visualized lymph nodes had mean values of -1.6 ± 1.7 cm (range -4.1 to -0.4 cm), -1.3 ± 1.5 cm (range -3.4 to 0.0 cm), and 1.2 ± 1.8 cm (range -1.0 to 2.6 cm) from the sacro-iliac (SI) joint at the superior, middle, and inferior points, respectively. The mean distance of the nodes from the pelvic rim at points 1 and 2 cm above the acetabulum was 0.3 ± 1.2 cm (range -0.6 to 1.8 cm) and 0.2 ± 1.8 cm (range -1.6 to 2.1 cm), respectively. On LAT simulation films, the distance of lymph nodes from points 0, 4, and 8 cm from the previously described reference line had mean values of 2.0 ± 1.0 cm (range 1.3 to 3.0 cm), 0.9 ± 3.9 cm (range -1.9 to 5.1 cm), and 1.8 ± 2.1 cm (range -0.8 to 3.5 cm), respectively. Ten of 22 (45%) patients would have had inadequate nodal irradiation if their fields had been designed according to standard GOG parameters. In all cases, these incompletely irradiated lymph nodes were from the lowest of the lateral external iliac group. Conclusions: Great variability in pelvic lymph node location is demonstrated when LAG is used to directly visualize their location. Bony structures are inaccurate landmarks for pelvic lymph node position. The GOG standard pelvic fields are not consistently adequate to cover all lateral external iliac lymph nodes, although the clinical significance of this subgroup of lymph nodes is not known. At this time, LAG remains the ideal radiographic modality to define anatomic location of regional lymph nodes for pelvic RT treatment planning. The clinical importance of the most lateral group of external iliac lymph nodes in various stages of cervical cancer represents a potential area of future research

  13. Traumatic mediastinal lesions: computed tomography findings

    International Nuclear Information System (INIS)

    Traumatic mediastinal lesions are unusual findings in patients with thoracic trauma but may represent poor prognosis and be associated with severe lesions. Mediastinal trauma is increasingly being diagnosed by computed tomography due to the fast acquisition times of helical techniques, allowing the evaluating of critically ill patients and the adoption of efficient therapeutic measures. The authors studied 11 patients with mediastinal lesions who were submitted to computed tomography due to thoracic trauma. The most frequent finding was mediastinal bleeding characterized by infiltration of mediastinal fat, dense material within the mediastinal spaces or hematoma. Hemo pericardium was the second most common lesion in this series, appearing as dense or liquid material in the pericardium. Aortic lesions such as wall irregularities or pseudoaneurisms were less commonly seen (three patients). In this study blunt thoracic traumas were observed in six cases whereas penetrating trauma occurred in five cases. The causes of blunt trauma were pedestrians struck by car, motor vehicle accidents and falls. Penetrating trauma was due to lesions produced by bullets or knifes. (author)

  14. Masticator space lesions: MRI and CT findings

    International Nuclear Information System (INIS)

    We evaluated the MR and CT findings of the masticator space lesions in order to identify the differences among the malignant and benign tumors and infectious conditions. MR and CT findings in 46 cases with proven masticator space lesions were reviewed retrospectively. We analysed the involvement of masticator muscles, adjacent spaces, orbit and intracranium, homogeneity, necrosis, cystic changes, growth patterns, calcifications, enhancement patterns, MR signal intensity, and CT attenuation. Among the 29 cases of malignant tumors, seven cases were mandibular tumors including four chondrosarcomas, and 22 cases were extramandibular tumors. Malignant tumors of mandibular origin showed large masses with severe bone destruction and epicenter of mandible. Extramandibular malignant tumors showed the epicenter out of the mandible and less severe bone destruction than mandibular tumors. Among the nine benign tumors, four cases were ameloblastomas which showed the well-defined masses and the expansion of the mandible, and four cases were extramandibular tumors which showed well-marginated extramandibular masses with no bone destruction. Among the eight infectious conditions, five cases were mandibular osteomyelitis with or without abscess formations, and the other three cases were infections from adjacent soft tissue or limited to the soft tissue. By careful observations of growth patterns, involvement of the masticator and adjacent spaces, bone changes, and epicenter of the leses, bone changes, and epicenter of the lesions, one can discriminate a mandibular lesion from an extramandibular lesion. With this approach, it is thought to be easier to suggest a diagnosis among a wide spectrum of masticator lesions

  15. Multimodality imaging of pediatric parotid gland lesions

    International Nuclear Information System (INIS)

    Although diseases of the parotid gland are relatively uncommon in children, a variety of benign and malignant lesions may occur and the use of imaging is essential for accurate diagnosis and treatment. Ultrasonography (US) is the initial imaging modality utilized for suspected parotid lesions, and its use may suggest a correct diagnosis in an adequate clinical setting. The use of computed tomography (CT) and magnetic resonance imaging (MRI) are useful for the assessment of large and atypical lesions. These modalities also allow the ability to image the deep parotid lobe and to better define the nature of a lesion. CT is the preferred imaging modality for inflammatory processes, including suspected sialolithiasis, abscesses and salivary duct obstructions, whereas MRI is usually used to evaluate tumors due to excellent anatomic resolution and a lack of ionizing radiation exposure, especially in children. This report describes the imaging findings of various parotid gland lesions in children. Familiarity with these findings will aid in lesion characterization and should facilitate optimal clinical management

  16. A solitary skull lesion of syphilitic osteomyelitis.

    Science.gov (United States)

    Kang, Suk Hyung; Park, Seung Won; Kwon, Ki Young; Hong, Won Jin

    2010-07-01

    We experienced a rare case of solitary syphilitic osteomyelitis of the skull without any other clinical signs or symptoms of syphilis. A 20-year-old man was referred due to intermittent headache and mild tenderness at the right parietal area of the skull with a palpable coin-sized lesion of softened cortical bone. On radiological studies, the lesion was a radiolucent well enhanced mass (17 mm in diameter). The erythrocyte sedimentation rate (52 mm/h) and C-reactive protein (2.24 mg/dL) were elevated on admission. Serum venereal disease research laboratory (VDRL) and Treponema pallidum haemagglutination assay (TPHA) tests were positive. There were no clinical signs or symptoms of syphilis. After treatment with benzathine penicillin, we removed the lesion and performed cranioplasty. The pathologic finding of the skull lesion was fibrous proliferation with lymphoplasmocytic infiltration forming an osteolytic lesion. In addition, a spirochete was identified using the Warthin-starry stain. The polymerase chain reaction study showed a positive band for Treponema pallidum. Solitary osteomyelitis of the skull can be the initial presenting pathological lesion of syphilis. PMID:20717520

  17. Texture feature based liver lesion classification

    Science.gov (United States)

    Doron, Yeela; Mayer-Wolf, Nitzan; Diamant, Idit; Greenspan, Hayit

    2014-03-01

    Liver lesion classification is a difficult clinical task. Computerized analysis can support clinical workflow by enabling more objective and reproducible evaluation. In this paper, we evaluate the contribution of several types of texture features for a computer-aided diagnostic (CAD) system which automatically classifies liver lesions from CT images. Based on the assumption that liver lesions of various classes differ in their texture characteristics, a variety of texture features were examined as lesion descriptors. Although texture features are often used for this task, there is currently a lack of detailed research focusing on the comparison across different texture features, or their combinations, on a given dataset. In this work we investigated the performance of Gray Level Co-occurrence Matrix (GLCM), Local Binary Patterns (LBP), Gabor, gray level intensity values and Gabor-based LBP (GLBP), where the features are obtained from a given lesion`s region of interest (ROI). For the classification module, SVM and KNN classifiers were examined. Using a single type of texture feature, best result of 91% accuracy, was obtained with Gabor filtering and SVM classification. Combination of Gabor, LBP and Intensity features improved the results to a final accuracy of 97%.

  18. Hypoechoic lesions without halo in echogenic liver

    International Nuclear Information System (INIS)

    Sonographic evaluation for the presence of hypoechoic hepatic lesions without halo was carried out in 365 consecutive patients with echogenic livers. In 115 patients (31%) such lesions could be demonstrated. Computed tomography of the liver was performed in 52 of these patients, a long term sonographic follow-up in 76, and a biopsy in 3 cases. In 103 patients the hypoechoic lesions were due to sonographic pseudolesions (PL's), probably representing normal liver tissue in otherwise diffusely fatty infiltrated livers. The PL's showed characteristic sonographic appearances such as a missing mass effect, a 'landscape'-like configuration with angulated margins and slender extensions of hypoechoic tissue. The PL's were located below the capsule, near the gallbladder (41%), and ventral to the portal vein (37%). In 75 per cent they occurred in a liver with considerably increased echogenicity. In 12 patients hypoechoic lesions were caused by circumscribed malignant or infectious involvement of the liver. They could be discriminated from PL's by their mass-like appearance in 8 subjects. In 4 of these 12 cases the foci were of PL-typical appearance, but not of PL-typical location. In the light of these results and of recently published reports a rational diagnostic approach to hypoechoic lesions without halo in echogenic livers varies, depending on such factors as known primary malignancy or site of the lesion. (orig.)

  19. The Felix-trial. Double-blind randomization of interspinous implant or bony decompression for treatment of spinal stenosis related intermittent neurogenic claudication

    Directory of Open Access Journals (Sweden)

    Brand Ronald

    2010-05-01

    Full Text Available Abstract Background Decompressive laminotomy is the standard surgical procedure in the treatment of patients with canal stenosis related intermittent neurogenic claudication. New techniques, such as interspinous process implants, claim a shorter hospital stay, less post-operative pain and equal long-term functional outcome. A comparative (cost- effectiveness study has not been performed yet. This protocol describes the design of a randomized controlled trial (RCT on (cost- effectiveness of the use of interspinous process implants versus conventional decompression surgery in patients with lumbar spinal stenosis. Methods/Design Patients (age 40-85 presenting with intermittent neurogenic claudication due to lumbar spinal stenosis lasting more than 3 months refractory to conservative treatment, are included. Randomization into interspinous implant surgery versus bony decompression surgery will take place in the operating room after induction of anesthesia. The primary outcome measure is the functional assessment of the patient measured by the Zurich Claudication Questionnaire (ZCQ, at 8 weeks and 1 year after surgery. Other outcome parameters include perceived recovery, leg and back pain, incidence of re-operations, complications, quality of life, medical consumption, absenteeism and costs. The study is a randomized multi-institutional trial, in which two surgical techniques are compared in a parallel group design. Patients and research nurses are kept blinded of the allocated treatment during the follow-up period of 1 year. Discussion Currently decompressive laminotomy is the golden standard in the surgical treatment of lumbar spinal stenosis. Whether surgery with interspinous implants is a reasonable alternative can be determined by this trial. Trial register Dutch Trial register number: NTR1307

  20. Use of CT simulation for treatment of cervical cancer to assess the adequacy of lymph node coverage of conventional pelvic fields based on bony landmarks

    International Nuclear Information System (INIS)

    Purpose: To assess the adequacy of nodal coverage of 'conventional' pelvic radiation fields for carcinoma of the cervix, with contoured pelvic vessels on simulation computed tomography (CT) as surrogates for lymph node location. Methods and Materials: Pelvic arteries were contoured on non-contrast-enhanced CT simulation images of 43 patients with cervix cancer, FIGO Stages I-III. Vessel contours were hidden, and conventional pelvic fields were outlined: (1) anterior/posterior fields (AP): superior border, L5-S1 interspace; inferior border, obturator foramina; lateral border, 2 centimeters lateral to pelvic brim. (2) Lateral fields (LAT): Anterior border, symphysis pubis; posterior border, S2-S3 interspace. Distances were measured between the following: (1) bifurcation of the common iliac artery and superior border (2) external iliac artery and lateral border of the AP field, and (3) external iliac artery and anterior border of the LAT field. The distances were considered as 'inadequate' if 20 mm. Results: Superiorly, 34 patients (79.1%) had inadequate coverage. On the AP, margins were generous in 19 (44.2%), but inadequate in 9 (20.9%). On the LAT, margins were inadequate in 30 (69.8%) patients. Overall, 41 (95.4%, CI, 84.2%-99.4%) patients had at least 1 inadequate margin, the majority located superiorly. Twenty-four (55.8%; CI, 39.9%-70.9%) patients had at least 1 generous margin, the majority located laterally on targin, the majority located laterally on the AP field. Conclusion: Conventional pelvic fields based on bony landmarks do not provide optimal lymph node coverage in a substantial proportion of patients and may include excess normal tissue in some. CT simulation with vessel contouring as a surrogate for lymph node localization provides more precise and individualized field delineation

  1. Placental lesions associated with acute atherosis.

    Science.gov (United States)

    Kim, Yeon Mee; Chaemsaithong, Piya; Romero, Roberto; Shaman, Majid; Kim, Chong Jai; Kim, Jung-Sun; Qureshi, Faisal; Jacques, Suzanne M; Ahmed, Ahmed I; Chaiworapongsa, Tinnakorn; Hassan, Sonia S; Yeo, Lami; Korzeniewski, Steven J

    2014-10-30

    Abstract Objective: Acute atherosis is a lesion of the spiral arteries characterized by fibrinoid necrosis of the vessel wall, an accumulation of fat-containing macrophages, and a mononuclear perivascular infiltrate, which can be found in patients with preeclampsia, fetal death, small-for-gestational age, spontaneous preterm labor/premature prelabor rupture of membrane, and spontaneous mid-trimester abortion. This lesion is thought to decrease blood flow to the intervillous space which may lead to other vascular lesions of the placenta. The objective of this study was to test whether there is an association between acute atherosis and placental lesions that are consistent with maternal vascular underperfusion (MVU), amniotic fluid infection (AFI), fetal vascular thrombo-occlusive disease (FVTOD) or chronic inflammation. Material and methods: A retrospective cohort study of pregnant women who delivered between July 1998 and July 2014 at Hutzel Women's Hospital/Detroit Medical Center was conducted examine 16?457 placentas. The frequency of placenta lesions (diagnosed using the criteria of the Perinatal Section of the Society for Pediatric Pathology) was compared between pregnancies with and without acute atherosis. Results: Among 16?457 women who were enrolled, 10.2% (1671/16?457) were excluded, leaving 14?786 women who contributed data for analysis. Among them, the prevalence of acute atherosis was 2.2% (326/14?786). Women with acute atherosis were more than six times as likely as those without to have placental lesions consistent with maternal underperfusion (adjusted odds ratio - aOR: 6.7; 95% CI 5.2-8.6). To a lesser degree, acute atherosis was also associated with greater risks of having either lesions consistent with FVTOD (aOR 1.7; 95% CI 1.2-2.3) or chronic chorioamnionitis (aOR 1.9; 95% CI 1.3-3), but not with other chronic inflammatory lesions, after adjusting for gestational age at delivery. In contrast, women with acute atherosis were 60% less likely to have lesions consistent with AFI, adjusting for gestational age at delivery (aOR 0.4; 95% CI 0.3-0.5). Conclusions: Acute atherosis is associated with increased risks of having placental lesions consistent with MVU, and to a lesser extent, chronic chorioamnionitis and those consistent with FVTOD. PMID:25183023

  2. Benign breast lesions in Eastern Nigeria

    International Nuclear Information System (INIS)

    Objective was to characterize benign breast diseases in Eastern Nigeria and to highlight the age variations of these lesions as base line data. The Department of Morbid Anatomy, University of Nigeria Teaching Hospital, Enugu caters for over 30 million African blacks and receives 2000 surgical pathology specimens yearly. Seven hundred and twenty-two benign breast specimens were analyzed over 5 years from Ist January 2000 to 31 December 2004, out of 1050 breast samples received. Of 1050 breast specimens received, 722 (68.8%) were benign. Fibroadenoma was the most common lesion with 318 cases (44%), occurring at a mean age of 16-32 years. Next were fibrocystic changes with 165 cases (22.9%) at a mean age of 23-45 years. Normal breast in the axillary tail region was seen in 32 cases (4.4%), represented as no pathology, with a mean presentation age of 20-46 years. Low grade Phyllodes tumor had 28 cases (3.9%), presenting at an average mean age of 17-32 years. Lactating adenoma had 19 (2.6%) cases. Other lesions made up less than 3% each. Benign breast lesions peaked at the 20-24 age range and then declined. Most were females. Benign breast lesions occur more frequently than malignant breast lesions with a ratio of 2.3:1 and were presented 20 years earlier than their malignant counterparts. Fibroadenoma was the most common benign lesions followed by fibrocystic disease, similar to the findings in Western Nigeria. In Northern Nigeria, fibrocystic breast disease was more comm, fibrocystic breast disease was more common. (author)

  3. Lesiones intraorales de glándulas salivales menores / Intraoral lesions of minor salivary glands. Analysis of 59 patients

    Scientific Electronic Library Online (English)

    MARÍA ANGÉLICA, MATAMALA S; MIGUEL, GONZÁLEZ P; GONZALO, ROSSEL D; CONSTANZA, NIEME S.

    2012-08-01

    Full Text Available Introducción: Las lesiones de glándulas salivales menores son en su mayoría benignas. Los tumores son infrecuentes y conforman un grupo heterogéneo, siendo el adenoma pleomorfo Ia neoplasia benigna más frecuente y el carcinoma adenoideo-quistico el tumor maligno más encontrado. Objetivos: El propósi [...] to de este estudio es evaluar Ia incidencia, manejo y evolución de Ias lesiones intraorales de glándulas salivales menores en el Servicio de Cirugia de Cabeza y Cuello del Hospital Barros Luco-Trudeau. Material y Método: Se presenta estudio retrospectivo de 59 casos tratados entre 1975 y 2009 en dicho hospital. Resultados: Encontramos 35 mujeres y 24 hombres. En 48 pacientes (81,3%) se encontró lesiones benignas, de Ias cuales 35 (73%) correspondieron a lesiones no neoplásicas y 13 (27%) a neoplasias. Las neoplasias malignas fueron 11 (18,6% del total), 4 (36,3%) con Ca mucoepidermoide, 2 (18%) con Ca adenoideo-quistico, 2 (18%) con Ca de células acinosas, 1 (9%) con Ca indiferenciado, 1 (9%) con adenocarcinoma y 1 (9%) con Ca epider-moide. Conclusiones: Las lesiones de glándulas salivales menores en nuestro hospital se caracterizan por ser predominantemente benignas. Se encontró similar frecuencia de tumores benignos y malignos. Predominó el adenoma pleomorfo entre Ios primeros y el carcinoma mucoepidermoide entre Ios segundos. Los tumores benignos, luego de su extirpación, se manejaron con cierre del lecho tumoral mediante rotación de colgajos locales de mucosa oral para cobertura y, en algunos casos, cierre por segunda intención. La evolución fue en general excelente. En el caso de Ios tumores malignos, el manejo dependió de Ia histología. Abstract in english Background: Most salivary gland lesions are benign. Tumors are uncommon. Pleomorphic adenoma and cystic adenoid carcinoma are the most common benign and malignant lesions. Alm: To assess the incidence management and evolution of intraoral lesions among patients consulting in a head and neck surgical [...] service. Material and Methods: Retrospective review of medical records of patients consulting for intraoral lesions of minor salivary glands between 1975 and 2009 in a head and neck surgical service. Results: Thirty five females and 24 males are reported. Forty eight (81%) had benign lesions. Of these, 35 (73%). were non neoplastic lesions. Eleven patients had malignant lesions. Of these, four (36%) had a mucoepidermoid carcinoma, two (18%) had an adenoid-cystic carcinoma, two (18%) had an acinous cell carcinoma and one patient each had an undifferentiated carcinoma, an adenocarcinoma and an epidermoid carcinoma. Conclusions: In this series of patients, benign lesions predominated. Benign lesions were excised and the management of malignant lesions depended on the type of tumor.

  4. Lesiones intraorales de glándulas salivales menores Intraoral lesions of minor salivary glands. Analysis of 59 patients

    Directory of Open Access Journals (Sweden)

    MARÍA ANGÉLICA MATAMALA S

    2012-08-01

    Full Text Available Introducción: Las lesiones de glándulas salivales menores son en su mayoría benignas. Los tumores son infrecuentes y conforman un grupo heterogéneo, siendo el adenoma pleomorfo Ia neoplasia benigna más frecuente y el carcinoma adenoideo-quistico el tumor maligno más encontrado. Objetivos: El propósito de este estudio es evaluar Ia incidencia, manejo y evolución de Ias lesiones intraorales de glándulas salivales menores en el Servicio de Cirugia de Cabeza y Cuello del Hospital Barros Luco-Trudeau. Material y Método: Se presenta estudio retrospectivo de 59 casos tratados entre 1975 y 2009 en dicho hospital. Resultados: Encontramos 35 mujeres y 24 hombres. En 48 pacientes (81,3% se encontró lesiones benignas, de Ias cuales 35 (73% correspondieron a lesiones no neoplásicas y 13 (27% a neoplasias. Las neoplasias malignas fueron 11 (18,6% del total, 4 (36,3% con Ca mucoepidermoide, 2 (18% con Ca adenoideo-quistico, 2 (18% con Ca de células acinosas, 1 (9% con Ca indiferenciado, 1 (9% con adenocarcinoma y 1 (9% con Ca epider-moide. Conclusiones: Las lesiones de glándulas salivales menores en nuestro hospital se caracterizan por ser predominantemente benignas. Se encontró similar frecuencia de tumores benignos y malignos. Predominó el adenoma pleomorfo entre Ios primeros y el carcinoma mucoepidermoide entre Ios segundos. Los tumores benignos, luego de su extirpación, se manejaron con cierre del lecho tumoral mediante rotación de colgajos locales de mucosa oral para cobertura y, en algunos casos, cierre por segunda intención. La evolución fue en general excelente. En el caso de Ios tumores malignos, el manejo dependió de Ia histología.Background: Most salivary gland lesions are benign. Tumors are uncommon. Pleomorphic adenoma and cystic adenoid carcinoma are the most common benign and malignant lesions. Alm: To assess the incidence management and evolution of intraoral lesions among patients consulting in a head and neck surgical service. Material and Methods: Retrospective review of medical records of patients consulting for intraoral lesions of minor salivary glands between 1975 and 2009 in a head and neck surgical service. Results: Thirty five females and 24 males are reported. Forty eight (81% had benign lesions. Of these, 35 (73%. were non neoplastic lesions. Eleven patients had malignant lesions. Of these, four (36% had a mucoepidermoid carcinoma, two (18% had an adenoid-cystic carcinoma, two (18% had an acinous cell carcinoma and one patient each had an undifferentiated carcinoma, an adenocarcinoma and an epidermoid carcinoma. Conclusions: In this series of patients, benign lesions predominated. Benign lesions were excised and the management of malignant lesions depended on the type of tumor.

  5. Evaluation of various hepatic lesions with PET

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    Han, Chul Ju

    2000-12-01

    When a liver lesion is found in a PET image, differential diagnosis and analysis of the lesion is very important. We tried to analyze hepatic lesions found in PET. 53 patients with focal liver lesions (13 patients with HCC, 8 patients with cholangiocarcinoma (CC), 20 patients with liver metastasis, 5 patients with hemangioma, 7 patients with liver abscess, including 1 patient with liver candidiasis) were examined. Definitely high FDG uptake pattern were observed in 54% (7/13) of HCC, 100% (8/8) of CC, 95% (19/20) of metastatic liver cancer and 100% (7/7) of liver abscess. Therefore, PET was partially useful in the diagnosis of HCC, but it was very useful in the diagnosis of CC or liver metastasis or liver abscess. The contrast between lesions and surrounding liver background was very conspicuous in PET images of CC or liver metastasis or liver abscess, which suggests that PET might be used for the follow up and assessment of treatment response of these diseases.

  6. My approach to atypical melanocytic lesions.

    Science.gov (United States)

    Culpepper, K S; Granter, S R; McKee, P H

    2004-11-01

    Histological assessment of melanocytic naevi constitutes a substantial proportion of a dermatopathologist's daily workload. Although they may be excised for cosmetic reasons, most lesions encountered are clinically atypical and are biopsied or excised to exclude melanoma. Although dysplastic naevi are most often encountered, cytological atypia may be a feature of several other melanocytic lesions, including genital type naevi, acral naevi, recurrent naevi, and neonatal or childhood naevi. With greater emphasis being given to cosmetic results, and because of an ever increasing workload, several "quicker and less traumatising" techniques have been introduced in the treatment and diagnosis of atypical naevi including punch, shave, and scoop shave biopsies. A major limitation to all of these alternatives is that often only part of the lesion is available for histological assessment and therefore all too frequently the pathologist's report includes a recommendation for complete excision so that the residual lesion can be studied. Complete or large excision of all clinically atypical naevi permits histological assessment of the entire lesion, and in most cases spares the patient the need for further surgical intervention. PMID:15509670

  7. Petrous apex lesions outcome in 21 cases

    Directory of Open Access Journals (Sweden)

    Hekmatara M

    1997-09-01

    Full Text Available Petrous apex lesions of temporal bone progress slowly. Most of the time not only destruct this area but also involve neighbouring element. The symptoms of the neighbouring neuro-vasculare involvement we can recognize these lesions. The most common symptoms of involvement of the petrous apex are: headache, conductive hearing loss or sensorineural type, paresthesia and anesthesia of the trigeminal nerve, paresia and paralysis of the facial nerve, abducent nerve. In retrospective study which has been in the ENT and HNS wards of Amiralam hospital, 148 patients have been operated due to temporal bone tumor; from these numbers, 21 (13.6% patients had petrous apex lesions of temporal bone. Eleven (52.9% patients of these 21 persons were men and the remaining 10 (47-6% were women. The average age of the patients was 37 years. The common pathology of these patients were glomus jugulare tumors, hemangioma, schwannoma, meningioma, congenital cholesteatoma, giant cell granuloma. The kind of operations that have been done on these patients were: infratemporal, translabyrinthine and middle fossa approaches. The conclusion of this study shows that petrous apex area is an occult site. The symptoms of this lesion are not characteristic, meticulous attention to the history and physical examination are very helpful to recognition of these lesions and it's extention.

  8. Evaluation of various hepatic lesions with PET

    International Nuclear Information System (INIS)

    When a liver lesion is found in a PET image, differential diagnosis and analysis of the lesion is very important. We tried to analyze hepatic lesions found in PET. 53 patients with focal liver lesions (13 patients with HCC, 8 patients with cholangiocarcinoma (CC), 20 patients with liver metastasis, 5 patients with hemangioma, 7 patients with liver abscess, including 1 patient with liver candidiasis) were examined. Definitely high FDG uptake pattern were observed in 54% (7/13) of HCC, 100% (8/8) of CC, 95% (19/20) of metastatic liver cancer and 100% (7/7) of liver abscess. Therefore, PET was partially useful in the diagnosis of HCC, but it was very useful in the diagnosis of CC or liver metastasis or liver abscess. The contrast between lesions and surrounding liver background was very conspicuous in PET images of CC or liver metastasis or liver abscess, which suggests that PET might be used for the follow up and assessment of treatment response of these diseases

  9. Iliopsoas compartment lesions: a radiologic evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Leao, Alberto Ribeiro de Souza; Amaral, Raquel Portugal Guimaraes; Abud, Thiago Giansante; Demarchi, Guilherme Tadeu Sauaia; Freire Filho, Edison de Oliveira; Novack, Paulo Rogerio; Campos, Flavio do Amaral; Shigueoka, David Carlos; Fernandes, Artur da Rocha Correa; Szejnfeld, Jacob; D' Ippolito, Giuseppe [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil). Dept. de Diagnostico por Imagem]. E-mail: ar.leao@uol.com.br; Santos, Jose Eduardo Mourao [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil)

    2007-07-15

    The iliopsoas compartment, a posterior boundary of the retroperitoneum, is comprised of the psoas major, psoas minor and iliac muscles. The symptoms picture in patients presenting with pathological involvement of this compartment may show a wide range of nonspecific clinical presentations that may lead to delayed diagnosis. However, in the search of an etiological diagnosis, it is already known that inflammation, tumors, and hemorrhages account for almost all the lesions affecting the iliopsoas compartment. By means of a retrospective analysis of radiological studies in patients with iliopsoas compartment lesions whose diagnosis was confirmed by anatomopathological evaluation or clinical follow-up, we have reviewed its anatomy as well as the main forms of involvement, with the purpose of identifying radiological signs that may help to narrow down the potential differential diagnoses. As each lesion is approached we will discuss the main radiological findings such as presence of gas in pyogenic abscesses, bone destruction and other bone changes of vertebral bodies in lesions secondary to tuberculosis, involvement of fascial planes in cases of neoplasms, and differences in signal density and intensity of hematomas secondary to hemoglobin degradation, among others. So, we have tried to present cases depicting the most frequent lesions involving the iliopsoas compartment, with emphasis on those signs that can lead us to a more specific etiological diagnosis. (author)

  10. Venocentric lesions: an MRI marker of MS?

    Directory of Open Access Journals (Sweden)

    MarceloKremenchutzky

    2013-07-01

    Full Text Available From the earliest descriptions of MS, the venocentric characteristic of plaques was noted. Recently, numerous MRI studies have proposed this finding as a prospective biomarker for MS, which might aid in differentiating MS from other diseases with similar MRI findings. High field MRI studies have shown that penetrating veins can be detected in most MS lesions using T2* weighted or susceptibility weighted imaging. Future studies must address the feasibility of imaging such veins in a clinically practical context. The specificity of this biomarker has been studied only in a limited capacity. Results in microangiopathic lesions are conflicting, whereas asymptomatic white matter hyperintensities as well as lesions of NMO are less frequently venocentric compared to MS plaques. Prospective studies have shown that the presence of venocentric lesions at an early clinical presentation is highly predictive of future MS diagnosis. This is very promising, but work remains to be done to confirm or exclude lesions of common MS mimics, such as ADEM, as venocentric. A number of technical challenges must be addressed before the introduction of this technique as a complementary tool in current diagnostic procedures.

  11. MR in phenylketonuria-related brain lesions

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    Dezortova, M.; Hajek, M.; Tintra, J. [Inst. for Clinical and Experimental Medicine, Prague (Czech Republic); Hejcmanova, L. [Charles University, Prague (Czech Republic). 3rd Medical Faculty; Sykova, E. [Charles University, Prague (Czech Republic). 2nd Medical Faculty

    2001-09-01

    Purpose: Phenylketonuria (PKU) patients were examined by different MR techniques to explain the pathological changes observed in periventricular white brain matter using conventional MR imaging. Material and Methods: Fifteen patients with treated classical PKU were examined by {sup 1}H spectroscopy, relaxometry and diffusion imaging on a whole-body 1.5-T MR imager. Results: Known PKU lesions characterized by T2 enhancement in periventricular white matter were observed in all patients. The MR spectra from the lesioned areas showed a significant decrease in choline concentration. The mean ADC of water decreased and tortuosity increased in PKU lesions compared to control data. Conclusion: The results support the following hypothesis: The T2 increase in the PKU lesion reflects a raised concentration of free water molecules (about 15%) that have an increased trajectory between collisions compared to the same region in controls. The increase in water mobility might be explained by changes in extracellular space volume and myelin sheaths, which, presumably, have a different geometry with more hydrophobic sites in PKU patients. The changes result in increased tortuosity and may be confirmed by the loss of anisotropy in PKU lesions.

  12. MR in phenylketonuria-related brain lesions

    International Nuclear Information System (INIS)

    Purpose: Phenylketonuria (PKU) patients were examined by different MR techniques to explain the pathological changes observed in periventricular white brain matter using conventional MR imaging. Material and Methods: Fifteen patients with treated classical PKU were examined by 1H spectroscopy, relaxometry and diffusion imaging on a whole-body 1.5-T MR imager. Results: Known PKU lesions characterized by T2 enhancement in periventricular white matter were observed in all patients. The MR spectra from the lesioned areas showed a significant decrease in choline concentration. The mean ADC of water decreased and tortuosity increased in PKU lesions compared to control data. Conclusion: The results support the following hypothesis: The T2 increase in the PKU lesion reflects a raised concentration of free water molecules (about 15%) that have an increased trajectory between collisions compared to the same region in controls. The increase in water mobility might be explained by changes in extracellular space volume and myelin sheaths, which, presumably, have a different geometry with more hydrophobic sites in PKU patients. The changes result in increased tortuosity and may be confirmed by the loss of anisotropy in PKU lesions

  13. Oral White Lesions: Presentation and Comparison of Oral Submucous Fibrosis with Other Lesions

    International Nuclear Information System (INIS)

    Objective: To compare oral submucous fibrosis with other white oral lesions for presentation and associated factors. Study Design: Cross-sectional study. Place and Duration of Study: The Departments of Oral Medicine and Oral and Maxillofacial Surgery, Dr. Ishrat-ul-Ibad Institute of Oral Health Sciences (DIKIOHS), Karachi, from May 2008 to May 2009. Methodology: Patients presenting with oral white lesions were selected by consecutive non-purposive sampling and clinico-demographic data was collected. For patients with oral submucous fibrosis (OSF), additional information like duration of habits, maximal incisal opening (MIO), presence of any other associated lesion were noted. OSF was compared with other white lesions for any association between characteristic of subjects. Chi-square and independent t-tests for determining the statistical significance at p < 0.05. Results: OSF was present in 59.6% (n = 106) of the 178 patients; other white lesions were 40.4% (n = 72). The mean age of patients with OSF was 34 +- 12.7 years and 45.81 +- 16.2 years in patients with other white lesions, (p < 0.0001). Items containing areca nut were consumed more by patients with OSF, with a significant (p < 0.0001) compared to patients with other white lesions. Conclusion: OSF was the predominant white lesion in patients examined at DIKIOHS. Areca nut was found to be chewed more by patients with OSF and still longer by patients with SCC. (author)

  14. Síndrome de Percheron: lesiones talámicas bilaterales / Percheron Syndrome: thalamic bilateral lesions

    Scientific Electronic Library Online (English)

    F.T., Salinas Vela; C., Arcos Sánchez.

    2014-03-01

    Full Text Available El síndrome de Percheron o infarto talámico bilateral sincrónico se considera infrecuente y de difícil diagnóstico clínico. Presentamos el caso de un paciente con lesiones isquémicas agudas en ambos tálamos y mesencéfalo anterior, compatibles con obstrucción del la arteria de Percheron. La compleja [...] irrigación talámica y la variabilidad individual hacen que las lesiones isquémicas puedan presentarse en forma de lesiones bilaterales y confieren importancia a este cuadro. La Resonancia Magnética cerebral (RM) es fundamental en el correcto diagnóstico. Abstract in english Percheron Syndrome also known as bilateral synchronic thalamic infarction is consider as an infrequent of difficult diagnosis syndrome. We describe the case of a male patient presenting acute ischemic lesions in both thalamus and anterior mesencephalon caused by an obstruction of the Percheron arter [...] y. The complexity of thalamic vascularization and individual differences make ischemic lesions appear as bilateral, that's the importance of this syndrome. Brain MRI is proposed as fundamental for a correct diagnosis.

  15. Early detection of bony alterations in rheumatoid and erosive arthritis of finger joints with high-resolution single photon emission computed tomography, and differentiation between them

    International Nuclear Information System (INIS)

    To evaluate high-resolution multi-pinhole single photon emission computed tomography (MPH-SPECT) for the detection of bony alterations in early rheumatoid arthritis (ERA), early osteoarthritis (EOA) of the fingers and healthy controls. The clinically dominant hands of 27 patients (13 ERA, nine EOA, five healthy controls) were examined by MPH-SPECT and bone scintigraphy. Additionally, magnetic resonance imaging (MRI) was performed in the ERA patients. Number of affected joints, localisation, pattern of tracer distribution and joint involvement were scored. Quantitative analysis was achieved by measurement of the region of interest (ROI) in all patients. The MPH-SPECT and MR images were fused in the ERA group. Bone scintigraphy detected fewer joints (26 joints,13/22 patients) with increased tracer uptake than did MPH-SPECT (80 joints, 21/22 patients). Bone scintigraphy did not show recognisable uptake patterns in any group of patients. With MPH-SPECT central tracer distribution was typical in ERA (10/13 patients, EOA 2/9). In contrast, an eccentric pattern was found predominantly in EOA (7/9, ERA 2/13). Normalised counts were 4.5 in unaffected joints and up to 222.7 in affected joints. The mean uptake values in affected joints were moderately higher in the EOA patients (78.75, and 62.16 in ERA). The mean tracer uptake in affected joints was approximately three-times higher than in unaffected joints in both groups (ERA 3.64-times higher, EOA 3.58). Correlation with MR im higher, EOA 3.58). Correlation with MR images revealed that bone marrow oedema and erosions matched pathological tracer accumulation of MPH-SPECT in 11/13. MPH-SPECT demonstrated increased activity in 2/13 patients with normal bone marrow signal intensity and synovitis seen on MR images. MPH-SPECT is sensitive to early changes in ERA and EOA and permits them to be distinguished by their patterns of uptake. (orig.)

  16. Development of mandibular, hyoid and hypobranchial muscles in the zebrafish: homologies and evolution of these muscles within bony fishes and tetrapods

    Directory of Open Access Journals (Sweden)

    Hinits Yaniv

    2008-02-01

    Full Text Available Abstract Background During vertebrate head evolution, muscle changes accompanied radical modification of the skeleton. Recent studies have suggested that muscles and their innervation evolve less rapidly than cartilage. The freshwater teleostean zebrafish (Danio rerio is the most studied actinopterygian model organism, and is sometimes taken to represent osteichthyans as a whole, which include bony fishes and tetrapods. Most work concerning zebrafish cranial muscles has focused on larval stages. We set out to describe the later development of zebrafish head muscles and compare muscle homologies across the Osteichthyes. Results We describe one new muscle and show that the number of mandibular, hyoid and hypobranchial muscles found in four day-old zebrafish larvae is similar to that found in the adult. However, the overall configuration and/or the number of divisions of these muscles change during development. For example, the undivided adductor mandibulae of early larvae gives rise to the adductor mandibulae sections A0, A1-OST, A2 and A?, and the protractor hyoideus becomes divided into dorsal and ventral portions in adults. There is not always a correspondence between the ontogeny of these muscles in the zebrafish and their evolution within the Osteichthyes. All of the 13 mandibular, hyoid and hypobranchial muscles present in the adult zebrafish are found in at least some other living teleosts, and all except the protractor hyoideus are found in at least some extant non-teleost actinopterygians. Of these muscles, about a quarter (intermandibularis anterior, adductor mandibulae, sternohyoideus are found in at least some living tetrapods, and a further quarter (levator arcus palatini, adductor arcus palatini, adductor operculi in at least some extant sarcopterygian fish. Conclusion Although the zebrafish occupies a rather derived phylogenetic position within actinopterygians and even within teleosts, with respect to the mandibular, hyoid and hypobranchial muscles it seems justified to consider it an appropriate representative of these two groups. Among these muscles, the three with clear homologues in tetrapods and the further three identified in sarcopterygian fish are particularly appropriate for comparisons of results between the actinopterygian zebrafish and the sarcopterygians.

  17. Sellar lesion: Not always a pituitary adenoma

    Directory of Open Access Journals (Sweden)

    Rao Shalinee

    2008-04-01

    Full Text Available Inflammatory lesions of the hypophysis account for 0.5% of all symptomatic diseases of the pituitary, which include lymphocytic hypophysitis, granulomatous hypophysitis with or without specific etiology and pituitary abscess. Sellar tuberculoma is a rare type of granulomatous hypophysitis. We document a case of a postmenopausal lady who presented with galactorrhea, headache and blurring of vision. Based on preliminary investigations, a clinical diagnosis of pituitary adenoma was made and the pituitary gland was surgically excised. Histopathological examination showed caseating granulomas, along with normal areas of preserved pituitary gland and a final diagnosis of tuberculous hypophysitis was made. This case is being documented due to the extremely rare involvement of the pituitary gland by granulomatous lesions such as tuberculosis and to emphasize the role of intraoperative consultation to obviate the need for radical surgery in such lesions.

  18. Evaluation of bone lesions of lymphomas

    International Nuclear Information System (INIS)

    Skeletal involvement of non-Hodgkin's lymphoma is found in 11-16%, in Hodgkin's disease in 7.6-34%. Primary lymphoma of bone has an incidence of 1-50% among all non-Hodgkin's lymphoma. The occurrence of skeletal lesions is higher in infants and children than in adults. Skeletal lesions caused by Hodgkin's and non-Hodgkin's lymphoma are mostly seen in the axial skeleton including the skull, whereas the primary lymphoma of bone seems to prefer a more peripheral site. The aggressiveness of the tumor growth can be measured by the method of Lodwick, by judging the edge characteristic, the penetration of the cortex, the periostal and scleotic reaction. 3 examples illustrate this method. Conventional radiographs need only be performed when there is reason to believe a lesion is located in an area of structural importance, such as the neck of the femur, and in cases of skeletal pain of unknown origin. (orig.)

  19. [Echographic possibilities in surgical lesions of infancy].

    Science.gov (United States)

    Durante, E

    1978-02-18

    The possibilities of applying ultrasound diagnosis techniques to the morphological and structural study of the soft tissues in infant surgical pathology have been examined. The technique's objective features mean that it is reliable in between 98 and 100% of cases of solid and cystic lesion identification and differentiation. In the further differentiation of solid lesions, such diagnostic accuracy may be limited by the operator's subjective experience and, objectively, by the dimensions of the lesions. Possibilities for application include thyroid, thoracic and abdominal pathology in preoperative diagnosis, postoperative control and in the monitoring of antineoplastic chemo- and radiotherapy. The peculiar features of the technique, i.e. its harmlessness and thus easy repeatibility, atraumaticity, and time and cost economy, are considered and it is concluded that it can be usefully employed on an extensive basis in the various field of infant surgical pathology, in view of the fact that other investigations always present some degree of risk and danger. PMID:634501

  20. Histopathologic Approach to Oral Cavity Lesions

    Directory of Open Access Journals (Sweden)

    Cuyan Demirkesen

    2012-12-01

    Full Text Available Diseases of the oral cavity may be either a reflection of system or cutaneous diseases or can be seen as a primary oral lesion. These lesions are inflammatory reactions due to miscellaneous mechanisms, ulceration or erosion, reactive proliferative nodules, precancerous or neoplastic diseases. In this study, microscopic features of the most common diseases, together with their differential diagnosis are discussed. Some of the diseases of the oral cavity have overlapping histopathological findings. In these conditions, ancillary methods such as immunoflourescence or immunohistochemistry can be performed. Deep biopsies from representative areas are essential for proper histopathological diagnosis. Moreover, informing the pathologist about the exact anatomic localization of the biopsy, as well as the clinical findings of the lesion is crucial for a better approach.

  1. Lesions in nerves and plexus after radiotherapy

    International Nuclear Information System (INIS)

    Apart from the typical, radiation-induced changes in the skin, common secondary findings were oedemas, radiation-induced ulceration, fibroses of the mediastinum and lungs, pleura adhesions, and osteoradionecroses. In one patient with radiogenic paresis of the plexus brachialis, irradiation of the spinal cord because of epidural metastases of a mammary carcinoma resulted in radiation myelopathy which was verified by laminectomy. Observations of radiogenic lesions of the plexus brachialis show that the usual site of the lesion in the vasomotoric nerve bundle is the axilla. The lesion is assumed to be caused mainly by an overlapping of the axillary, infraclavicular and supraclavicular fields of irradiation which results in a dose peak in the axilla. (orig./AJ) 891 AJ/orig.- 892 MKO

  2. Fine-needle aspiration of splenic lesions

    International Nuclear Information System (INIS)

    To evaluate the safety and usefulness of percutaneous fine needle aspiration biopsy of the splenic lesions. Fine needle aspiration biopsy was done in 7 patients with splenic lesions. Spleen puncture was performed by using 22 gauge Chiba needle, under ultrasound guidance in 6 patients and CT guidance in one patient. No major complication such as bleeding, infection or pneumothorax occurred. Final diagnosis were 2 cases of splenic lymphoma and one case each of metastasis, cystic lymphangioma, tuberculosis, hemangioma, and extramedullary hematopoiesis. Cytologic results were true positive in 4 patients and were clinically useful in all patients. This study shows that FNAB of splenic lesions may be a valuable procedure safe from major complications such as fatal bleeding

  3. Morgellons Disease Presenting As an Eyelid Lesion.

    Science.gov (United States)

    Sandhu, Rasanamar K; Steele, Eric A

    2014-09-01

    Morgellons disease is characterized by complaints of uncomfortable skin sensations and fibers emanating from nonhealing skin lesions. Morgellons disease is well-known in the dermatology and psychiatry literature, where it is typically considered a subtype of delusional parasitosis, but it has not yet been described in the ophthalmology literature. A patient with self-reported Morgellons disease is presented, who was referred for evaluation of left lower eyelid ectropion. She reported that her skin was infested with fibers that were "trying to get down into the eyelid." On examination, she had ectropion of the left lower eyelid, broken cilia, and an ulcerated left upper eyelid lesion concerning for carcinoma. Biopsy of the lesion was consistent with excoriation. Treatment of her ectropion was deferred out of concern for wound dehiscence, given the patient's aggressive excoriation behavior. This case is presented to make the ophthalmologist aware of this disorder and to highlight the appropriate clinical management. PMID:25192328

  4. Lentigo maligna and contiguous pigmented lesion

    Directory of Open Access Journals (Sweden)

    Havva Erdem

    2013-03-01

    Full Text Available Lentigo maligna (LM, a subtype of melanoma in-situ, is seen mostly in patients between 50 and 80 years old and accounts for ten to fifteen percent of skin cancer cases. LM is a traditional term for atypical pigmented macular lesions. LM occurs on severely sun damaged skin and it is usually on the face of elderly patients. Histological diagnosis of atypical pigmented macular lesions have extensive range from solar lentigo to in-situ melanoma (lentigo maligna pattern or invasive invasive melanoma (lentigo maligna melanoma. The presence of solar lentigo, pigmented actinic keratosis, or reticulated seborrheic keratosis in incisional specimen could misguide the pathologist and clinician. they might think that lentigo maligna is not present. Therefore, excisional biopsy is needed in such cases. Our aim in presenting this case was to emphasize the importance of clinicopathologic correlation and to attract attention on the lesions adjacent to lentigo maligna which can lead to a misdiagnosis.

  5. LESIONES MUSCULARES DEPORTIVAS: DIAGNOSTICO POR IMAGENES

    Directory of Open Access Journals (Sweden)

    Sara Muñoz Ch.

    2002-01-01

    Full Text Available La gran mayoría de la patología muscular es de origen traumático y relacionado a la actividad deportiva. Alrededor de un 30% de las lesiones en atletas afectan los músculos: En los últimos años ha habido un importante progreso en el diagnóstico de estas lesiones principalmente relacionado al avance de las técnicas de imagen, en especial la ultrasonografía y la resonancia magnética. Se revisa la experiencia del autor en los diferentes tipos de lesión muscular ilustrándola con ejemplos de ellosThe vast majority of the muscle pathology is traumatic in origin related to sport activity. Approximately 30% of the injuries in athletes affect the muscles. In the last few years, there has been important progress in the diagnosis of these lesions mainly due to the advanced imaging technology, especially ultrasound and magnetic resonance. In this article, the author discusses the different types of muscles injuries, and show examples of each one

  6. Decoding Diffusivity in Multiple Sclerosis: Analysis of Optic Radiation Lesional and Non-Lesional White Matter

    Science.gov (United States)

    Klistorner, Alexander; Vootakuru, Nikitha; Wang, Chenyu; Yiannikas, Con; Graham, Stuart L.; Parratt, John; Garrick, Raymond; Levin, Netta; Masters, Lynette; Lagopoulos, Jim; Barnett, Michael H.

    2015-01-01

    Objectives Diffusion tensor imaging (DTI) has been suggested as a new promising tool in MS that may provide greater pathological specificity than conventional MRI, helping, therefore, to elucidate disease pathogenesis and monitor therapeutic efficacy. However, the pathological substrates that underpin alterations in brain tissue diffusivity are not yet fully delineated. Tract-specific DTI analysis has previously been proposed in an attempt to alleviate this problem. Here, we extended this approach by segmenting a single tract into areas bound by seemingly similar pathological processes, which may better delineate the potential association between DTI metrics and underlying tissue damage. Method Several compartments were segmented in optic radiation (OR) of 50 relapsing-remitting MS patients including T2 lesions, proximal and distal parts of fibers transected by lesion and fibers with no discernable pathology throughout the entire length of the OR. Results Asymmetry analysis between lesional and non-lesional fibers demonstrated a marked increase in Radial Diffusivity (RD), which was topographically limited to focal T2 lesions and potentially relates to the lesional myelin loss. A relative elevation of Axial Diffusivity (AD) in the distal part of the lesional fibers was observed in a distribution consistent with Wallerian degeneration, while diffusivity in the proximal portion of transected axons remained normal. A moderate, but significant elevation of RD in OR non-lesional fibers was strongly associated with the global (but not local) T2 lesion burden and is probably related to microscopic demyelination undetected by conventional MRI. Conclusion This study highlights the utility of the compartmentalization approach in elucidating the pathological substrates of diffusivity and demonstrates the presence of tissue-specific patterns of altered diffusivity in MS, providing further evidence that DTI is a sensitive marker of tissue damage in both lesions and NAWM. Our results suggest that, at least within the OR, parallel and perpendicular diffusivities are affected by tissue restructuring related to distinct pathological processes. PMID:25807541

  7. CT Guided Needle Biopsies in Mediastinal Lesions

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    Ali Fani

    2011-05-01

    Full Text Available Background/Objective: The present study was"nperformed to determine the incidence of mediastinal"npathologies by CT-guided needle biopsy in mediastinal"nlesions."nPatients and Methods: We performed CT guided"nneedle biopsy on 62 cases of mediastinal lesions after"nthe physician's request. Thoracic CT scan with a 64-"nslice MSCT was done for all patients before the needle"nbiopsy. All biopsies were performed by one experienced"ninterventional radiologist using a semiautomatic"ncoaxial 18 guage needle. The results were confirmed"nby two pathologists who were unaware of each other's"nreports. Because of different pathological reports, two"ncases were excluded from the study."nResults: The study population included 44 men and"n16 women with the mean age of 48 years (range, 26-"n69 years. The mean lesion diameter was 45 mm (±10"nmm. Most of the mediastinal lesions were located in"nthe anterior mediastinum (53%, 33.3% of the cases"nwere in paramediastinal areas and 13.3% of the lesions"nwere in the posterior mediastinum. Fifty two cases"nwere diagnosed as neoplastic lesions, non Hodgkin"nlymphoma was the most common of them (33.3% in"nboth sexes. Thymoma was detected in 12 cases (20%,"ninfiltrative carcinoma in 12 cases (20%, malignant"nperipheral nerve sheat tumor (MPNST in eight"npatients (13.3%. Bronchogenic cyst was detected in"nfour cases and fibroconnective inflammatory tissue was"ndiagnosed in four patients. Final diagnosis was made"nfor all the cases (except for non Hodgkin lymphoma"nand inflammatory cases through surgery."nConclusion: In this study, most mediastinal lesions"nwere neoplastic and non Hodgkin lymphoma was the"nmost common."nKeywords: Mediastinum, Needle Biopsy, CT Guide

  8. Lesiones bucales relacionadas con las enfermedades digestivas

    Directory of Open Access Journals (Sweden)

    José A. Pacho Saavedra

    2006-09-01

    Full Text Available Muchas de las lesiones de la mucosa en la cavidad bucal están relacionadas con trastornos anatómicos y funcionales de los órganos del aparato digestivo; algunas forman parte del cuadro clínico de la entidad y otras aparecen como complicaciones de estas. Generalmente son de orígenes inmunológicos, nutricionales o carenciales. Estas lesiones son difíciles de tratar, por lo que es importante conocer las características clínicas que faciliten una adecuada interpretación y al mismo tiempo ofrecer una conducta terapéutica correcta. Se presenta una revisión actualizada de las características semiológicas de las lesiones bucales que forman parte del cuadro clínico de diversas enfermedades digestivas, con el fin de que los médicos generales, clínicos, estomatólogos y gastroenterólogos puedan diagnosticarlas y brindar mejor orientación y tratamiento a los pacientes.Many of the lesions of the mucosa in the oral cavity are related to anatomical and functional disorders of the organs of the digestive system. Some of them are part of the clinical picture of the entity and others appear as complications of them. Generally, they have an immunological, nutritional, or deficiency origin. These lesions are difficult to be treated and that's why it is important to know the clinical characteristics making easy an adequate interpretation, and to follow a suitable therapeutic conduct at the same time. An updated review of the semiological features of the oral lesions corresponding to the clinical picture of diverse digestive diseases is presented, so that the general physicians, clinicians, stomatologists and gastroenterologists be able to diagnose and give a better guidance and treatment to the patients.

  9. CT diagnosis of cystic ovarian lesions

    International Nuclear Information System (INIS)

    CT was undertaken and CT numbers were measured in 47 patients with cystic ovarian lesions. CT features particularly for chocolate cyst revealed the uniform thickness of the whole cystic wall, findings suggesting adhesion to the surrounding organs, circular or oval shape, and higher CT numbers within the cyst than those in the other cystic ovarian lesions. However, because these features are not always observed in cases of chocolate cyst, one should not rely solely on CT findings in the diagnosis of chocolate cyst. (Namekawa, K.)

  10. Carnoy's in Aggressive Lesions: Our Experience.

    Science.gov (United States)

    Rajeshkumar, B P; Rai, Kirthi Kumar; Geetha, N T; Shivakumar, H R; Upasi, Amarnath P

    2013-03-01

    Carnoy's solution is used in the treatment of various aggressive cysts and tumors in the maxillofacial region as a chemical cauterizing agent. Its use has been extensively studied in case of odontogenic keratocysts. It is used in the management of unicystic ameloblastomas and ossifying fibromas. In our institution from 2006 to 2010 we have treated 14 cases of maxillofacial lesions using carnoy's solution. Among these cases 7 were of odontogenic keratocyst, 4 cases were of amelobalstoma and one case was of juvenile ossifying fibroma. So here we share our experience of treating these lesions with the carnoy's solution. PMID:24431812

  11. Post-traumatic contrast enhancing brain lesion

    International Nuclear Information System (INIS)

    Only a few studies have been reported on the MR contrast enhancement and the apparent diffusion coefficient (ADC) findings of the post-traumatic lesion of the brain. We report a case of the venous ischemia in the left frontal lobe observed in the MRI obtained one day after the incidence of trauma. Considering the presented slight increase in the ADC, the vasogenic edema was thought to be the major mechanism of the venous ischemia and excitotoxic injury. In spite of a slight increase in the ADC, the hyperintensity in the diffusion weighted imaging and contrast-enhanced areas eventually changed into hemorrhagic lesions.

  12. Computed tomography of the retrofascial space lesions

    International Nuclear Information System (INIS)

    CT offers a unique method to evaluate anatomy of the retrofascial space. Retrofascial space which mainly consist of psoas and quadratus lumborum muscles locates behind the transversalis fascia. CT findings of 10 lesions, five with abscess and five with hematoma were reviewed. CT provided clinically useful information regarding the presence, size, extent and composition of the lesions and also their effects on adjacent structures. Abscesses revealed a well-defined low density with enhanced rim in the enlarged muscle. Hematoma showed an illdefined low density area within the enlarged muscle. Abscesses can not be differentiated from hematomas and other retrofascial tumors by CT alone. (author)

  13. A Solitary Skull Lesion of Syphilitic Osteomyelitis

    OpenAIRE

    Kang, Suk Hyung; Park, Seung Won; Kwon, Ki Young; Hong, Won Jin

    2010-01-01

    We experienced a rare case of solitary syphilitic osteomyelitis of the skull without any other clinical signs or symptoms of syphilis. A 20-year-old man was referred due to intermittent headache and mild tenderness at the right parietal area of the skull with a palpable coin-sized lesion of softened cortical bone. On radiological studies, the lesion was a radiolucent well enhanced mass (17 mm in diameter). The erythrocyte sedimentation rate (52 mm/h) and C-reactive protein (2.24 mg/dL) were e...

  14. Occult cervical spinal lesions in craniocerebral trauma

    International Nuclear Information System (INIS)

    Because traumatic lesions of the cervical spine associated with major skull injuries are difficult to diagnose (especially in neurologic intensive care patients), the authors studied 32 cervical spines from accident victims who had died with craniocerebral injuries. The external and internal head injuries were mapped. The in situ frozen spines were radiographed in vitro by an experienced skeletal radiologist, and then they were cryoplaned and photographed. An unexpected high incidence of significant lesions was found, although most radiographic studies were negative. The pattern of injuries included severe, frequently multilevel, disk ruptures; ligament- and joint-capsule ruptures; and radiologically occult discoligamentous bone evulsions

  15. Stereotactic thalamic lesions studied by CT scanner

    International Nuclear Information System (INIS)

    The authors illustrate four cases of stereotactic CM-PF thalamotomy for pain syndromes and their evolutions seen on computer tomograms. The brain specimen from one is shown. The CT appearance of these lesions is composed of two relatively clear distinct parts: a discrete central core of increased attenuation, and an area of decreased attenuation surrounding the central core. In all CT slices the position of the lesion in relation to the ventricular landmarks shows good agreement with the Schaltenbrand Atlas demonstration of the thalamic nuclei. (Author)

  16. Tumefactive demyelinating lesion: Experience with two unusual patients

    OpenAIRE

    Sinha M; Garg R.; Mlb, Bhatt; Chandra A

    2010-01-01

    Tumefactive demyelinating lesion, a variant of multiple sclerosis, is a solitary large demyelinating lesion, which mimics cerebral neoplasm. Distinguishing tumefactive lesions from other etiologies of intracranial space-occupying lesions is essential to avoid inadvertent surgical or toxic chemotherapeutic interventions. We report two unusual cases of tumefactive demyelinating lesion. The first patient presented with recurrent right focal tonic-clonic seizures with secondary generalization of ...

  17. Adrenal imaging (Part 1): Imaging techniques and primary cortical lesions

    OpenAIRE

    Panda, Ananya; Das, Chandan J.; Dhamija, Ekta; Kumar, Rakesh; Gupta, A. K.

    2015-01-01

    Adrenal glands can be affected by a variety of lesions. Adrenal lesions can either be primary, of adrenal origin, or secondary to other pathologies. Primary adrenal lesions can further be either of cortical or medullary origin. Functioning adrenal lesions can also give clues to the histologic diagnosis and direct workup. Over the years, various imaging techniques have been developed that have increased diagnostic accuracy and helped in better characterization of adrenal lesions non-invasively...

  18. The wide spectrum of hyperechoic lesions of the breast

    International Nuclear Information System (INIS)

    Although breast lesions are commonly detected because of their hypoechogenicity, some lesions may present with hyperechogenicity due to their histological components. Hyperechogenicity has been shown to be highly predictive of benignity; however, hyperechoic lesions can occasionally be malignant. This article reviews hyperechoic lesions of the breast, describes the underlying histological causes associated with hyperechogenicity, and the sonographic features useful for the differential diagnosis between benign and malignant hyperechoic lesions.

  19. Assessing culprit lesions and active complex lesions in patients with early acute myocardial infarction by multidetector computed tomography

    International Nuclear Information System (INIS)

    Accurate, non-invasive characterization of culprit lesions in patients after acute myocardial infarction (AMI) remains challenging. In this prospective study, multidetector row computed tomography (MDCT) is used to assess culprit and active complex lesions in patients early after AMI. We enrolled 103 patients with first non ST-elevation AMI who underwent 64-slices MDCT and conventional coronary angiography (CCAG). The definition of culprit lesion, stable non-culprit lesions and non-culprit active complex lesions was based on the findings of CCAG. The lesions were analyzed with MDCT data. In culprit lesions (n=103), luminal artery stenosis, remodeling index, plaque area and burden were significantly higher than non-culprit lesions (n=129). Multivariate discriminant analysis showed that MDCT density could discriminate culprit from non-culprit lesions. Receiver-operator characteristic curve analysis identified the optimal cutoff value of lesion density for discrimination between culprit and non-culprit lesion as 49.6 Hounsfield units (HU); this value was associated with a sensitivity, specificity and accuracy of 88.4%, 87.4%, and 87.9%, respectively. The MDCT in the stable non-culprit lesions (81.8±15.5 HU) was significantly higher than that in culprit lesions or non-culprit active complex lesions (33.2±13.8 and 48.3±15.7 HU, p<0.001). MDCT can predict culprit lesions in patients early after AMI, and identify multiple complex lesions. (author)ions. (author)

  20. Chondrogenic Lesions of the Skeletal System Using Radiographs, CT and MRI

    Directory of Open Access Journals (Sweden)

    Akbar Bonakdarpour

    2011-05-01

    Full Text Available Benign Tumors: Chondroma, chondroblastoma,"nchondromyxoid fibroma, osteochondroma"nChondroma"n1. Enchondroma"n2. Periosteal Chondroma"n3. Enchondromatosis"n4. Metachondromatosis"nEnchondroma is a benign metaphyseal tumor. The"nmajor differential diagnoses are bone infarct and"nchondrosarcoma. Calcification in enchondroma"nhas a popcorn appearance and on radiographs and"nCT they may be counted. Calcified bone infarct"nhas an appearance similar to rotten metal. Central"nchondrosarcoma shows cortical erosion more than"ntwo thirds of the thickness of cortex and also periosteal"nreaction. Pain and growth of lesion in adulthood raises"nthe possibility of malignant transformation."nPeriosteal chondroma: This lesion arises from the"nperiosteum without involving the medullary bone."nThe most common location is the upper humerus."nEnchondromatosis reveals multiple enchondromas,"npredominantly involving one side of the skeleton."nMalignant transformation is the major complication"nof enchondromatosis. In malignant transformation,"nMRI shows that perichondrium is more than 1 cm"nthick in adults and more than 3 cm thick in children."nIn the hands and feet, enchondromatosis should not"nbe confused with fibrous dysplasia. Mafucci syndrome"nis enchondromatosis associated with cavernous"nhemangiomas with a prognosis worse than enchondr"nomatosis."nMultiple hereditary cartilaginous exostoses: This is"nof metaphyseal origin and pedunculated forms grow"naway from the adjacent joint. Sessile osteochondromas"nare broad based; if their surface is irregular they are"nsuspicious of malignancy. Pain and growth of the"nlesion after closure of the epiphyseal plate are warning"nsigns of malignant transformation. In malignant"ntransformation MRI shows that perichondrium is"nmore than 1 cm thick in adults and more than 3 cm"nthick in children."nChondroblastoma: This is a benign tumor, seen before"nclosure of epiphyseal plate, with a sclerotic border."n30 to 50% show calcification. CT and MRI confirm"nradiographic findings. The tumor is hypodense in T1"nand hyperdense in T2 and post gadolinium injection"nfat suppressed T1 images. CT and MRI confirm"nradiographic findings."nChondromyxoid Fibroma-A benign, eccentric, ovoid,"nmetaphyseal tumor with recurrent tendency. It rarely"nshows calcification. The tumor is hypodense on T1 and"nIran J Radiol 2011, 8 (Supp.1 S65"nhyper dense on T2 and post gadolinium studies show"nhyperintensity beyond the tumor. It has a tendency"nfor recurrence. Non-ossifying fibroma is a self healing"nmetaphyseal fibrous defect and not a tumor, diamond"nshaped in one of the perpendicular radiographs."nMetaphyseal fibrous defect is usually subcortical, but"nit may be small and intracortical. CT and MRI confirm"nradiographic findings."nSynovial chondrometaplasia. (synovial"nosteochondromatosis is an arthritis resulting"nfrom chondro (or osteochondro metaplasia of the"nsynovium. They may form osteocartilaginous bodies"nin the joint. In advanced cases they may cause erosion of"nthe articular surface and malignant transportation has"nbeen reported. Radiographs may demonstrate chondroosseous"nbodies in the joints, but CT demonstrates them"nbetter. MRI shows joint fluid and filling defects in the"nfluid. Erosion may be demonstrated by these three"nmodalities."nChondrosarcoma:"nConventional Chondrosarcoma: central, peripheral"nand juxtacortical."nVariants of chondrosarcoma: clear cell, mesenchymal"nand dedifferentiated. Chondrosarcoma can be"ndifferentiated from enchondroma by the presence"nof cortical erosion more than two thirds of the"ncortical diameter and periosteal reaction. Most"nchondrosarcomas discussed here are of low grad

  1. A Comparison of the Use of Bony Anatomy and Internal Markers for Offline Verification and an Evaluation of the Potential Benefit of Online and Offline Verification Protocols for Prostate Radiotherapy

    International Nuclear Information System (INIS)

    Purpose: To evaluate the utility of intraprostatic markers in the treatment verification of prostate cancer radiotherapy. Specific aims were: to compare the effectiveness of offline correction protocols, either using gold markers or bony anatomy; to estimate the potential benefit of online correction protocol's using gold markers; to determine the presence and effect of intrafraction motion. Methods and Materials: Thirty patients with three gold markers inserted had pretreatment and posttreatment images acquired and were treated using an offline correction protocol and gold markers. Retrospectively, an offline protocol was applied using bony anatomy and an online protocol using gold markers. Results: The systematic errors were reduced from 1.3, 1.9, and 2.5 mm to 1.1, 1.1, and 1.5 mm in the right-left (RL), superoinferior (SI), and anteroposterior (AP) directions, respectively, using the offline correction protocol and gold markers instead of bony anatomy. The subsequent decrease in margins was 1.7, 3.3, and 4 mm in the RL, SI, and AP directions, respectively. An offline correction protocol combined with an online correction protocol in the first four fractions reduced random errors further to 0.9, 1.1, and 1.0 mm in the RL, SI, and AP directions, respectively. A daily online protocol reduced all errors to <1 mm. Intrafraction motion had greater impact on the effectiveness of the online protocol than the offline protocols. Conclusions: An offline protocol using gold mclusions: An offline protocol using gold markers is effective in reducing the systematic error. The value of online protocols is reduced by intrafraction motion

  2. Fine needle aspiration biopsy in orbital lesions.

    Science.gov (United States)

    Rastogi, Anju; Jain, Shyama

    2001-03-01

    PURPOSE. The study was performed to evaluate the efficacy of fine needle aspiration biopsy (FNAB) in orbital lesions. METHODS. Seventeen patients with orbital masses who had been fully investigated by non-invasive techniques participated in this study. FNAB was performed by standard technique, as an outpatient procedure, with ultrasound guidance in lesions posterior to the equator. A trained cytologist analysed all the smears. RESULTS. Specific results were obtained in 14 of the 17 (82%) patients studied by FNAB. Ten cases were neoplastic (8 malignant and 2 benign), 3 were inflammatory and 1 was a case of histiocytosis X. In 3/17 cases the results were non-specific. These were treated as pseudotumours and responded well to systemic steroids. In 7 cases the clinical and radiological diagnosis was confirmed by FNAB. Non-invasive investigations like USG, CT and MRI, however, failed to provide accurate diagnosis in the other 7 (41%) cases. In these patients, FNAB yielded a pathological diagnosis (histiocytosis X, cryptococcosis, non Hodgkin's lymphoma, adenocarcinoma, pleomorphic adenoma, Schwannoma and cysticercosis), helping us to modify treatment with an excellent response. No significant complications were encountered following the aspiration biopsies. CONCLUSION. FNAB proved to be a reliable method for distinguishing between malignant and non-malignant lesions. It was found to be rapid, accurate, cost-effective, safe and a valuable addition to ultrasound, CT scan and MRI in the diagnosis of orbital lesions. This tool may help in avoiding a traumatic surgical intervention. PMID:12045931

  3. Precancerous Lesions of the Oral Mucosa

    Directory of Open Access Journals (Sweden)

    Oya Gürbüz

    2012-12-01

    Full Text Available In this review of oral precancerous lesions, leukoplakia, erythroleukoplakia/erythroplakia and the least common variant proliferative verrucous leukoplakia will be focused with their clinical characteristics and their potential to develop oral squamous cell carcinoma and related factors will be discussed.

  4. [Appropriate surgical approach to cystic thymic lesions].

    Science.gov (United States)

    Matsumura, Yuji; Minowa, Muneo; Araki, Osamu; Karube, Youko; Eba, Syunsuke; Notsuda, Yasutsugu; Sato, Kouta; Suzuki, Hirotoshi

    2012-10-01

    We retrospectively analyzed surgical approach to cystic thymic lesions based on 25 cases. We classified to 4 groups as follows, 12 thin-wall solitary cysts with low uniform density, 7 solitary cysts with ununiform density, 5 cysts with tumor lesions and 1 multiple cysts. Preoperative image diagnoses were 10 thymic cysts, 7 cystic thymomas, 4 mature teratomas, and 1 each of multilocular thymic cyst and thymic lymphoma. Twenty cases were indicated to video-assisted thoracic surgery( VATS), the other 5 cases were operated by sternotomy. The reasons for thoracotomy were adherence with left brachiocephalic vein(LBCV)3, huge cyst compressing superior vena cava (SVC) 1, diffuse multiple cysts and tumors in hypertrophic thymus 1. Three cases were converted to open thracotomy from VATS because of dense adhesions around LBCV and malignant diagnosis. Final diagnosis are 16 congenital cysts, 3 thymomas, and one each multilocular thymic cyst, mature teratoma, thymic cancer, thymolipoma, venous hemangioma and mucosal associated lymphoid tissue( MALT) lymphoma. Thin-wall solitary cysts with low uniform density are able to diagnosed congenital thymic cysts by computed tomography( CT)/magnetic resonance imaging (MRI) appearances. On the contrary un-uniform density cysts or cysts with tumor lesions are difficult to achieve correct diagnoses by images. These lesions may contain thymoma or thymic cancer, so that rapid pathological examination should be prepared during surgical operation. Cysts adhering to LBCV should be operated by thoracotomy to avoid accidents of massive bleeding. PMID:23023536

  5. [Pseudosarcomatous lesions: report of two cases].

    Science.gov (United States)

    Pasta, V; Torcasio, A; Tintisona, O; Veneroso, S; Sardella, B; Vergine, M; Amabile, M I; D'Aulerio, A; Chiarini, S; Stella, S; Monti, M

    2006-04-01

    Of unknown etiology, mainly located on the upper limbs, the nodular fasciitis nowadays is considered as a reactive inflammatory lesion more than a neoplastic one. With very few symptoms, it can be diagnosed through histology and the extent of the excision is related to the report of the pathological examination. PMID:16768870

  6. Tibial cortical lesions: a multimodality pictorial review.

    Science.gov (United States)

    Tyler, P A; Mohaghegh, P; Foley, J; Isaac, A; Zavareh, A; Thorning, C; Kirwadi, A; Pressney, I; Amary, F; Rajeswaran, G

    2015-01-01

    Shin pain is a common complaint, particularly in young and active patients, with a wide range of potential diagnoses and resulting implications. We review the natural history and multimodality imaging findings of the more common causes of cortically-based tibial lesions, as well as the rarer pathologies less frequently encountered in a general radiology department. PMID:25445894

  7. MRI of fetal acquired brain lesions

    Energy Technology Data Exchange (ETDEWEB)

    Prayer, Daniela [Department of Radiodiagnostics, Medical University of Vienna (Austria)]. E-mail: daniela.prayer@meduniwien.ac.at; Brugger, Peter C. [Center of Anatomy and Cell Biology, Medical University of Vienna (Austria); Kasprian, Gregor [Department of Radiodiagnostics, Medical University of Vienna (Austria); Witzani, Linde [Department of Radiodiagnostics, Medical University of Vienna (Austria); Helmer, Hanns [Department of Obstetrics and Gynecology, Medical University of Vienna (Austria); Dietrich, Wolfgang [Department of Neurosurgery, Medical University of Vienna (Austria); Eppel, Wolfgang [Department of Obstetrics and Gynecology, Medical University of Vienna (Austria); Langer, Martin [Department of Obstetrics and Gynecology, Medical University of Vienna (Austria)

    2006-02-15

    Acquired fetal brain damage is suspected in cases of destruction of previously normally formed tissue, the primary cause of which is hypoxia. Fetal brain damage may occur as a consequence of acute or chronic maternal diseases, with acute diseases causing impairment of oxygen delivery to the fetal brain, and chronic diseases interfering with normal, placental development. Infections, metabolic diseases, feto-fetal transfusion syndrome, toxic agents, mechanical traumatic events, iatrogenic accidents, and space-occupying lesions may also qualify as pathologic conditions that initiate intrauterine brain damage. MR manifestations of acute fetal brain injury (such as hemorrhage or acute ischemic lesions) can easily be recognized, as they are hardly different from postnatal lesions. The availability of diffusion-weighted sequences enhances the sensitivity in recognizing acute ischemic lesions. Recent hemorrhages are usually readily depicted on T2 (*) sequences, where they display hypointense signals. Chronic fetal brain injury may be characterized by nonspecific changes that must be attributable to the presence of an acquired cerebral pathology. The workup in suspected acquired fetal brain injury also includes the assessment of extra-CNS organs that may be affected by an underlying pathology. Finally, the placenta, as the organ that mediates oxygen delivery from the maternal circulation to the fetus, must be examined on MR images.

  8. MRI of fetal acquired brain lesions

    International Nuclear Information System (INIS)

    Acquired fetal brain damage is suspected in cases of destruction of previously normally formed tissue, the primary cause of which is hypoxia. Fetal brain damage may occur as a consequence of acute or chronic maternal diseases, with acute diseases causing impairment of oxygen delivery to the fetal brain, and chronic diseases interfering with normal, placental development. Infections, metabolic diseases, feto-fetal transfusion syndrome, toxic agents, mechanical traumatic events, iatrogenic accidents, and space-occupying lesions may also qualify as pathologic conditions that initiate intrauterine brain damage. MR manifestations of acute fetal brain injury (such as hemorrhage or acute ischemic lesions) can easily be recognized, as they are hardly different from postnatal lesions. The availability of diffusion-weighted sequences enhances the sensitivity in recognizing acute ischemic lesions. Recent hemorrhages are usually readily depicted on T2 (*) sequences, where they display hypointense signals. Chronic fetal brain injury may be characterized by nonspecific changes that must be attributable to the presence of an acquired cerebral pathology. The workup in suspected acquired fetal brain injury also includes the assessment of extra-CNS organs that may be affected by an underlying pathology. Finally, the placenta, as the organ that mediates oxygen delivery from the maternal circulation to the fetus, must be examined on MR images

  9. Scoliosis secondary to an unusual rib lesion.

    LENUS (Irish Health Repository)

    Burke, N G

    2012-04-01

    Tumours of the chest wall are uncommon and are usually malignant. A bone haemangioma is a rare benign vascular neoplasm, which more commonly occurs in middle-aged patients. We present the case of a scoliosis caused by a rib haemangioma in an adolescent male. Other causes of scoliosis secondary to rib lesions are discussed.

  10. Magnetic resonance imaging of cranial radiation lesions

    International Nuclear Information System (INIS)

    Fifty-six patients who previously received therapeutic cranial irradiation (CRT) were imaged by a 1.5 Magnetic Resonance (MR) System 0.1-11 years following CRT. Abnormal MR findings within the treatment volume unrelated to tumor, prior to surgery, or coexisting conditions were reviewed for an association with CRT. Twenty-four patients had MR abnormalities considered to be attributable to CRT. These were scored as mild (Grade I) in 6, moderate (Grade II) in 9, and severe (Grade III) in 9. Eight of these 24 patients with CRT findings on MR had CT abnormalities that correlated with the MR. Six lesions seen on computed tomography (CT) were Grade III abnormalities; all were judged as being visualized better by MR. Eight patients had significant neurologic dysfunction attributable to their CRT lesions, and 7 of these had Grade III lesions. Whereas the clinical significance of mild or moderate CRT effects seen on MR is uncertain, Grade III (severe) MR lesions correlate well with important clinical findings

  11. Simulating Clinical Carious Lesions in Composition Teeth.

    Science.gov (United States)

    Ambrose, E. R.; And Others

    1981-01-01

    A step-by-step technique to alter stock composition teeth and create simulated carious conditions that are ideal or otherwise is presented. The procedures provide the student with life-like lesions, suitable in texture and location and similar to conditions found in the oral cavity. (MLW)

  12. Calcified lesion modeling for excimer laser ablation

    Science.gov (United States)

    Scott, Holly A.; Archuleta, Andrew; Splinter, Robert

    2009-06-01

    Objective: Develop a representative calcium target model to evaluate penetration of calcified plaque lesions during atherectomy procedures using 308 nm Excimer laser ablation. Materials and Methods: An in-vitro model representing human calcified plaque was analyzed using Plaster-of-Paris and cement based composite materials as well as a fibrinogen model. The materials were tested for mechanical consistency. The most likely candidate(s) resulting from initial mechanical and chemical screening was submitted for ablation testing. The penetration rate of specific multi-fiber catheter designs and a single fiber probe was obtained and compared to that in human cadaver calcified plaque. The effects of lasing parameters and catheter tip design on penetration speed in a representative calcified model were verified against the results in human cadaver specimens. Results: In Plaster of Paris, the best penetration was obtained using the single fiber tip configuration operating at 100 Fluence, 120 Hz. Calcified human lesions are twice as hard, twice as elastic as and much more complex than Plaster of Paris. Penetration of human calcified specimens was highly inconsistent and varied significantly from specimen to specimen and within individual specimens. Conclusions: Although Plaster of Paris demonstrated predictable increases in penetration with higher energy density and repetition rate, it can not be considered a totally representative laser ablation model for calcified lesions. This is in part due to the more heterogeneous nature and higher density composition of cadaver intravascular human calcified occlusions. Further testing will require a more representative model of human calcified lesions.

  13. Corticoides intralesionales en lesiones a células gigantes

    Directory of Open Access Journals (Sweden)

    J.P. Crestanello Nese

    2003-12-01

    Full Text Available Desde su descripción original, las lesiones de células gigantes (LCG han sido entidades controvertidas, desde el punto de vista de su origen, de su comportamiento clínico, de sus características radiográficas e histológicas, así como de su tratamiento. Para su tratamiento se han considerado alternativas quirúrgicas y no quirúrgicas. En este trabajo, se presentan tres nuevos casos de LCG, en los cuales se realizó infiltración intralesional con corticoides como una maniobra previa y complementaria a la quirúrgica. Luego de la infiltración, se observó una disminución del tamaño de las lesiones y un cambio en sus características macroscópicas, se trato por enucleación un caso y por remodelación quirúrgica los dos restantes.Giant cell lesions (GCL have been controversial entities since its original description. Its origin, clinical behavior, radiographic and histological features and also its treatment are polemical. The therapeutic possibilities are surgical or non surgical. In this paper, the intralesional infiltration with steroids is presented like a previous and complementary therapy to surgery alone. Three new cases of GCL are presented. All of them were first treated with intralesional infiltration with steroids. After that,a partial remission and a change of the macroscopic characteristics were observed and one of the lesion was then enucleated while for the others two surgical remodelation were necessary to do.

  14. Plant Disease Lesson: Lesion nematode disease

    Science.gov (United States)

    Eric L. Davis (North Carolina State University; )

    2000-10-30

    This plant disease lesson on Lesion nematode disease (caused by Pratylenchus) includes information on symptoms and signs, pathogen biology, disease cycle and epidemiology, disease management, and the significance of the disease. Selected references are listed and a glossary is also available for use with this resource.

  15. Lesiones cutáneas en educadores físicos costarricenses

    Directory of Open Access Journals (Sweden)

    José Moncada Jiménez

    2004-09-01

    Full Text Available Justificación y objetivo: Los educadores físicos representan una población laboral que se expone crónicamente a la radiación solar. No se han descrito las lesiones cutáneas en este grupo de personas. El propósito del estudio fue describir la incidencia de lesiones cutáneas en educadores físicos costarricenses. Métodos: En total, participaron voluntariamente 23 hombres (48.9% y 24 mujeres (51.1%, a quienes se les aplicó un cuestionario. Los 47 participantes fueron revisados por un médico del Servicio de Dermatología del Hospital R. A. Calderón Guardia de la Caja Costarricense de Seguro Social. Se obtuvo información demográfica, fenotipo, salud general y horario de trabajo, prendas de vestir utilizadas para laborar, protección y cuidado de la piel, historia familiar y personal de cáncer de piel, y ubicación anatómica de las lesiones. Resultados y discusión: Las lesiones cutáneas se ubicaron en las regiones del rostro, el pecho, la espalda alta, los brazos y los muslos. Hubo 3 casos con antecedentes familiares de cáncer de piel, y una persona presentó antecedentes personales (no melanoma. Se encontraron lesiones premalignas en 5 sujetos (6.3%. Se recomienda evitar la exposición solar; una revisión anual con el dermatólogo; un autoexamen de piel completo mensualmente; el uso de prendas de vestir cuya translucidez sea poca, hechas de un material como el algodón, idealmente de color claro; también el uso de gorra o sombrero, anteojos oscuros, filtros solares, y si fuera posible, cambiar horarios de trabajo para horas cuando ocurre la menor radiación solar.Purpose: In Costa Rica, physical education professionals are chronically exposed to solar radiation throughout their lives. However, skin lesions in this group of workers have not been described so far. The purpose of this study was to describe the incidence of skin lesions in this professionals in Costa Rica. Methods: Twenty-three males (48.9% and twenty-four females (51.1% volunteers answered a questionnaire and were examined by a dermatologist from the Dermatology Service of the Rafael Angel Calderon Guardia Hospital. Information on demographics, phototype, general health status, work schedule, clothing, skin and sun protection, family and personal history for skin cancer, and anatomic region of the skin lesion were obtained. Results and discussion: In general, most lesions were found in the face, chest, shoulders, back, arms, and thighs. There were 3 cases of family history of skin cancer; and one case of personal history (non melanoma of skin cancer. Pre-malignant lesions suggestive of skin cancer were found in 5 cases (6.3%. In conclusion, avoiding excessive sun exposure and a yearly visit to a dermatologist is recornmended. It is also important to perform a monthly self-examination of the skin, to wear sun glasses, hat, sun blockers, and thick-layered lightcolored preferably cotton clothes. Agradecimientos Un agradecimiento especial a los educadores físicos que voluntariamente participaron en este estudio; al comité organizador del Congreso Nacional de Educación Física, por facilitamos una sala adecuada para la revisión médica; al Dr. Daniel Rodríguez Guerrero, Jefe del Servicio de Medicina del Hospital Rafael Ángel Calderón Guardia (HRACG; al Dr. Luis Paulino Hernández Castañeda, Director del HRACG; y al Dr. Alvaro Chen Chen, jefe del Servicio de Dermatología del HRACG., por brindar los permisos correspondientes para que los médicos participaran en el estudio.

  16. Lesiones cutáneas en educadores físicos costarricenses

    Scientific Electronic Library Online (English)

    José, Moncada Jiménez; Maureen, Meneses Montero; Benjamin, Hidalgo Matlock; Caridad, Granados Chavarría.

    2004-09-01

    Full Text Available Justificación y objetivo: Los educadores físicos representan una población laboral que se expone crónicamente a la radiación solar. No se han descrito las lesiones cutáneas en este grupo de personas. El propósito del estudio fue describir la incidencia de lesiones cutáneas en educadores físicos cost [...] arricenses. Métodos: En total, participaron voluntariamente 23 hombres (48.9%) y 24 mujeres (51.1%), a quienes se les aplicó un cuestionario. Los 47 participantes fueron revisados por un médico del Servicio de Dermatología del Hospital R. A. Calderón Guardia de la Caja Costarricense de Seguro Social. Se obtuvo información demográfica, fenotipo, salud general y horario de trabajo, prendas de vestir utilizadas para laborar, protección y cuidado de la piel, historia familiar y personal de cáncer de piel, y ubicación anatómica de las lesiones. Resultados y discusión: Las lesiones cutáneas se ubicaron en las regiones del rostro, el pecho, la espalda alta, los brazos y los muslos. Hubo 3 casos con antecedentes familiares de cáncer de piel, y una persona presentó antecedentes personales (no melanoma). Se encontraron lesiones premalignas en 5 sujetos (6.3%). Se recomienda evitar la exposición solar; una revisión anual con el dermatólogo; un autoexamen de piel completo mensualmente; el uso de prendas de vestir cuya translucidez sea poca, hechas de un material como el algodón, idealmente de color claro; también el uso de gorra o sombrero, anteojos oscuros, filtros solares, y si fuera posible, cambiar horarios de trabajo para horas cuando ocurre la menor radiación solar. Abstract in english Purpose: In Costa Rica, physical education professionals are chronically exposed to solar radiation throughout their lives. However, skin lesions in this group of workers have not been described so far. The purpose of this study was to describe the incidence of skin lesions in this professionals in [...] Costa Rica. Methods: Twenty-three males (48.9%) and twenty-four females (51.1%) volunteers answered a questionnaire and were examined by a dermatologist from the Dermatology Service of the Rafael Angel Calderon Guardia Hospital. Information on demographics, phototype, general health status, work schedule, clothing, skin and sun protection, family and personal history for skin cancer, and anatomic region of the skin lesion were obtained. Results and discussion: In general, most lesions were found in the face, chest, shoulders, back, arms, and thighs. There were 3 cases of family history of skin cancer; and one case of personal history (non melanoma) of skin cancer. Pre-malignant lesions suggestive of skin cancer were found in 5 cases (6.3%). In conclusion, avoiding excessive sun exposure and a yearly visit to a dermatologist is recornmended. It is also important to perform a monthly self-examination of the skin, to wear sun glasses, hat, sun blockers, and thick-layered lightcolored preferably cotton clothes. Agradecimientos Un agradecimiento especial a los educadores físicos que voluntariamente participaron en este estudio; al comité organizador del Congreso Nacional de Educación Física, por facilitamos una sala adecuada para la revisión médica; al Dr. Daniel Rodríguez Guerrero, Jefe del Servicio de Medicina del Hospital Rafael Ángel Calderón Guardia (HRACG); al Dr. Luis Paulino Hernández Castañeda, Director del HRACG; y al Dr. Alvaro Chen Chen, jefe del Servicio de Dermatología del HRACG., por brindar los permisos correspondientes para que los médicos participaran en el estudio.

  17. Lesiones craneofaciales producidas en hockey sobre patines

    Scientific Electronic Library Online (English)

    Emiliano G, Pelaez; Pamela F, Dascenzi; Luís E, Savastano; Fabián E, Cremaschi.

    2008-12-01

    Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Objetivo. Los principales objetivos son obtener registros estadísticos acerca de la incidencia, mecanismos, severidad y tipo más frecuente de lesiones cráneo faciales debido a la práctica de hockey sobre patines, para mostrar el grado de rudeza de este deporte, evaluando la necesidad de revisar las [...] reglas del juego y sugerir nuevas medidas de seguridad. Material y método. Presentamos las cifras estadísticas obtenidas de 119 partidos del Campeonato Mendocino (Argentina) jugado entre 2004 y 2005, con un seguimiento de 18 meses. Se utilizó un test standard . Resultados. Encontramos 85 lesiones en 54 partidos; el 59% fueron producidas en la primer mitad del juego, el 41% restante en el segundo tiempo; los forwards recibieron el 48% de las lesiones, los backs 44% y los arqueros 9%. Las estructuras afectadas fueron: cara (61%), región frontal, (15%), columna cervical (7%), región parietal (6%), región temporal (6%) y región occipital (5%). La mayoría involucra estructuras faciales donde: labios (37%), nariz (25%), órbita (21%) y mentón (11%). Las lesiones fueron debidas al palo (39%), el codo (24%), la pelota (21%), el patín (5%), la cabeza (4%), la pared (4%) y finalmente, el hombro (1%).Un 26% de los jugadores lastimados no pudieron seguir jugando; 26% de los lesionados necesitaron intervención médica en el campo de juego; 16% fueron trasladados al hospital (70% permanecieron en observación); 64% de las lesiones fueron contusión, 36% heridas cortantes (sutira quirúrgica 77% y química 33%); 3% de las lesiones estuvieron asociadas con pérdida de la conciencia; se registraron 8 fracturas. Conclusión. Estos datos epidemiológicos confirman la necesidad de revisar y reconsiderar las reglas del juego y su seguridad. Abstract in english Objectives: Research on this topic is carried out because no statistical records are available in order to conduct epidemiological studies. The main objectives are to obtain statistical records regarding the incidence, mechanisms, severity, and most frequent cranio-facial injuries due to the practic [...] e of roller hockey, to show the degree of roughness of this sport, assessing the need to revise the rules of the game, suggesting new safety precautions for this sport. Material and Method: The methodology is based on statistical figures obtained from 119 matches of the Mendoza (Argentina) Championship played between 2004 and 2005, with a follow up of 18 months. A standard test was used. Results: We found 85 injuries in 54 matches; 59% of the lesions were produced in the first half of the game, the 41% remaining in the second half; the forwards received 48% of the lesions, the back 44% and the goalkeepers 9%. The affected structures were: face (61%), frontal region (15%), cervical spine (7%), parietal region (6%), temporal region (6%) and occipital region (5%). Most involved facial structures were: lips (37%), nose (25%), eye socket (21%) and chin (11%). The injuries were due to the stick (39%), the elbow (24%), the ball (21%), the skate (5%), the head (4%), the wall (4%) and last the shoulder (1%). A 26% of injured players were not able to continue playing; 26% of injured players needed medical intervention on the game field; 16% were taken to a hospital (70% remained under observation); 64% of lesions were contusion, 36% were cutting wounds (surgical suture 77% and chemical suture 33%); 3% of lesions were associated with loss of consciousness; 8 fractures were registered. Conclusion: Epidemiological data confirm the need to revise and reconsider the rules of the game and their safety.

  18. Oral lesions in patients with psychiatric disorders

    Directory of Open Access Journals (Sweden)

    Gaji? Ivanka

    2010-01-01

    Full Text Available Introduction. Oral diseases in psychiatric patients are usually a result of bad oral hygiene and psychopharmaceutical side-effects. Objective. The aim of this study was to detect oral lesions in patients hospitalized in psychiatric institutions with the confirmed diagnosis of psychiatric illness and mood disorder with psychotic characteristics, as well as to discover the factors that can influence these oral lesions. Methods. Cross-section study consisted of 186 hospitalized patients with psychiatric disorders in the experimental group, out of whom 87 were males and 99 females. Patients were aged from 18 to 59 years, mean age 46.0±8.0 years. The control group consisted of 186 healthy persons matched for age and gender. Data on oral lesions were obtained within history and clinical examination of the oral cavity. Other medical data were collected from medical documentation. Statistical analysis was performed by Student’s t-test, chi-square test and logistic regression. Results. Dry mouth was registered in 78.5% of patients. The difference in tongue and lip lesions, burning and stinging symptoms, bruxism, facial pain, low saliva rates, halitosis, taste changes and swallowing difficulties between the patients and healthy persons was highly statistically significant (p<0.001. Age and gender, as well as the factors of main disease, influence burning and stinging, bruxism, low saliva rates, swallowing difficulties, taste changes and facial pain of the psychiatric patients. Conclusion. Results imply that psychiatric patients are more frequently involved with oral lesions than healthy persons. It is necessary to organize specific preventive and educational oral health programmes with these patients, as well as with doctors who treat the basic illness.

  19. Diabetic foot lesions: etiologic and prognostic factors.

    Science.gov (United States)

    Benotmane, A; Mohammedi, F; Ayad, F; Kadi, K; Azzouz, A

    2000-04-01

    The clinical characteristics of 132 diabetic patients referred for treatment of foot lesions were surveyed. One hundred and sixty three lesions (n=163) concerned 88 men and 44 women during a five-year period (from January 1989 to December 1993). Hospitalisation rate equalled 9.16%, i.e. 11.17% for men and 6.82% for women (p habits were noticed only in men. Inadequate footwear was considered as the major exogenous risk factor leading to a foot lesion. The definitive results 6 months after hospitalisation were as follows: the death rate was 9.09% (n=2; 11 men and 1 women, NS); 15.90% of patients (n=12) underwent a major amputation (4 at the level of the thigh, 17 at the level of the leg), 14.39% of patients (n=19) underwent a minor amputation; in 59.09% of patients (n=78) there was no amputation. Two patients (1.51%) underwent two consecutive amputations, left hospital against medical advice during their second hospitalisation, and then were lost sight. The prevalence of foot lesions was more important in men. Moreover, seriousness of the lesions and consequently the rate of amputations were important in men; this was probably due to smoking habits. The factors that influence the outcome seem to be: male gender, delay of management, quality of medical treatment, surgical attitude, inadequate level of amputation and finally lack of structured prevention. Prevention then should be based on the patient's education, general practitioners' training and a better and more efficient cooperation between surgeons and diabetologists. PMID:10804325

  20. Computed tomographic findings of traumatic intracranial lesions

    International Nuclear Information System (INIS)

    Traumatic intracranial lesion has been one of the most frequent and serious problem in neurosurgical pathology. Computed tomography made it possible to get prompt diagnosis and surgical intervention of intracranial lesions by its safety, fastness and accuracy. Computed tomographic scan was carried out on 1309 cases at Soonchunhyang Chunan Hospital for 15 months from October 1983 to December 1984. We have reviewed the computed tomographic scans of 264 patients which showed traumatic intracranial lesion. The result were as follows: 1. Head trauma was the most frequent diagnosed disease using computed tomographic scans (57.8%) and among 264 cases the most frequent mode of injury was traffic accident (73.9%). 2. Skull fracture was accompanied in frequency of 69.7% and it was detected in CT in 38.6%: depression fracture was more easily detected in 81%. 3. Conutercoup lesion (9.5%) was usually accompanied with temporal and occipital fracture, and it appeared in lower incidence among pediatric group. 4. Intracranial lesions of all 264 cases were generalized cerebral swelling (24.6%), subdural hematoma (22.3%), epidural hematoma (20.8%), intracerebral hematoma (6.1%), and subarachnoid hemorrhage (3.0%). 5. The shape of hematoma was usually biconvex (92.7%) in acute epidural hematoma and cresentic (100%) in acute subdural hematoma, but the most chronic the case became, they showed planoconvex and bicconvex shapes. 6. Extra-axial hematoma was getting decreased in density as timma was getting decreased in density as time gone by. 7. Hematoma density was not in direct proportion to serum hemoglobin level as single factor

  1. Penile lesion from gunshot wound: a 43-case experience

    Directory of Open Access Journals (Sweden)

    Cavalcanti Andre G.

    2006-01-01

    Full Text Available OBJECTIVE: To demonstrate the main aspects of diagnosis, treatment and follow-up of 43 patients with gunshot wounds to the penis. MATERIALS AND METHODS: The location of the lesion, the presence of associated lesions, the performance of complementary exams, surgical treatment, postoperative complications and long term follow-up of 43 patients with penile lesions from gunshot wounds were retrospectively analyzed. RESULTS: Of 43 cases assessed, 41 were submitted to surgical exploration (95.3% and 2 were submitted to conservative treatment (4.7%. We found penile lesions involving the corpus cavernosum in 37 cases; the remaining 4 patients presented no lesions involving the corpus cavernosum, urethra or testicles but did in the superficial structures. Ten cases presented an association with testicular lesions and 14 cases association with anterior urethral lesions. CONCLUSION: Penile lesions from gunshot wounds should be treated with immediate surgical intervention. In exceptional situations featuring superficial lesions only conservative treatment may be applied.

  2. Management of Large Preiapical Lesion with the Combination of Second Generation Platelet Extract and Hydroxyapatite Bone Graft: A Report of Three Cases

    Science.gov (United States)

    Kumar, Ashok; Tewari, Rajendra Kumar; Mishra, Surendra Kumar; Iftekhar, Huma

    2015-01-01

    The pulp tissue necrosis and extensive periodontal diseases leads to the development of the inflammatory periapical lesion which causes a local response of bone around the apex of the tooth. Depends upon the nature of wound and available biological growth factors the outcome will be either regeneration or repair. Being a rich source of growth factors, platelet rich fibrin (PRF) posses many advantages in bone regeneration. The purpose of this case report is to present an attempt to evaluate the healing potential of the combination of PRF and Hydroxyapatite bone graft as opposed to using these materials alone. A periapical endodontic surgery was performed on three patients with a large periapical inflammatory lesion and a large bony defect. The defect was then filled with a combination of PRF and Hydroxyapatite bone graft crystals. Clinical examination exhibited uneventful wound healing. The HA crystals have been replaced by new bone radiographically at the end of two years in Case 1 and Case 2, Case 3 were followed upto one year. On the basis of our cases outcome, we conclude the use of PRF in combination with HA crystals might have accelerate the bone regeneration. PMID:25738094

  3. Columnar cell lesions of the breast: Mammographic and US features

    International Nuclear Information System (INIS)

    Objectives: Columnar cell lesions are being encountered with increasing frequency in breast biopsies performed. The purpose of our study was to determine whether columnar cell lesions of the breast have any distinctive imaging characteristics. Materials and methods: We retrospectively reviewed our institutional database for all records of breast pathology obtained in a 17-month period. Columnar cell lesion was diagnosed in 53 lesions and 12 of these 53 lesions contained columnar cell lesions as the sole histopathologic findings. These 12 lesions in nine patients made up our study population. They included columnar cell change (n = 4), columnar cell hyperplasia (n = 5), and columnar cell hyperplasia with atypia (n = 3). Results: All nine patients underwent mammography and sonography within 1 month of each other. Of the mammograms in nine patients, nine lesions (75%) appeared as clustered amorphous or indistinct (n = 5), fine pleomorphic (n = 3), or round (n = 1) microcalcifications. The tenth lesion showed a focal mass without microcalcifications and the remaining two lesions showed no abnormal findings. At sonography, not-circumscribed masses were depicted in six lesions and microcalcifications were visible in four lesions, of which three lesions were concurrent with masses. There were no sonographically focal lesions in the remaining five. Overall 11 lesions were classified as BI-RADS category 4 (92%) and one as category 3. Of the three lesions with atypia, two were f the three lesions with atypia, two were classified as category 4a and one was classified as category 4c, and they showed no distinct imaging appearance from those without atypia. Conclusion: Columnar cell lesions usually present as nonpalpable, clustered indeterminate or suspicious microcalcifications on mammography. They are indistinguishable from other causes of suspicious microcalcifications such as atypical ductal hyperplasia or ductal carcinoma in situ and require needle biopsy or excisional biopsy for diagnosis

  4. Morphometry and Variations of Bony Ponticles of the Atlas Vertebrae (C1) in Kenyans / Morfometría y Variaciones de Puentes Óseos de la Vértebra Atlas (C1) en Kenianos

    Scientific Electronic Library Online (English)

    P, Karau Bundi; J. A, Ogeng´o; J, Hassanali; P. O, Odula.

    1019-10-01

    Full Text Available SciELO Chile | Language: English Abstract in spanish Puentes del atlas, sobrecrecimientos óseos en el tercer segmento de la arteria vertebral se asocian con la compresión de la arteria y los nervios. Hay pocos estudios que comparan la morfometría de los puentes completos del atlas y el foramen transversal ipsilateral. Diferencias bilaterales y de géne [...] ro en la morfometría de los puentes completos permanecen relativamente inexplorados. Ciento dos vértebras atlas (49 hombres y 53 mujeres) obtenidos del Departamento de Osteología de los Museos Nacionales de Kenya se utilizaron para este estudio. Fueron identificados la presencia de puentes completos posteriores del atlas (canal retroarticular) y puentes laterales (foramen supratransverso). Se realizaron las mediciones de los diámetros del foramen y los forámenes transversos ipsilaterales, y se calcularon sus áreas. Puentes completos posteriores se observaron en el 14,6% y 13,6% de los lados derecho e izquierdo, respectivamente. El puente lateral se encontró en el 3,9% de los casos en el lado derecho solamente. Los puentes completos posteriores tuvieron un área transversal de 23,44mm2 en el lado derecho y 24,98mm2 en el lado izquierdo. Los puentes laterales tuvieron un área media de sección transversal de 27,30mm2. En los lados derecho e izquierdo se encontrron forámenes transversos con un área promedio de sección transversal de 36,30mm2 y 37,20mm2 respectivamente, lo que fue significativamente mayor que el de los puentes completos ipsilaterales y posteriores. Las dimensiones más pequeñas de los puentes atlas completos en comparación con los forámenes transversos ipsilaterales sugieren que pueden predisponer a la insuficiencia vertebrobasilar, síndromes de Barre-Lieou y cervical debido a la compresión de los contenidos en los forámenes. Abstract in english Atlas bridges, the bony outgrowths over the third segment of the vertebral artery are associated with compression of the artery and nerves. There are limited studies comparing morphometry of the complete atlas bridges and that of the ipsilateral transverse foramen. Bilateral and gender differences i [...] n the morphometry of the complete bridges remain relatively unexplored. One hundred and two atlas vertebrae (49 male and 53 female) obtained from the Osteology Department of the National Museums of Kenya were used for this study. The presence of complete posterior atlas bridge (retroarticular canal) and lateral bridge (supratransverse foramen) was noted. Measurements were taken for the diameters of foramina, and the ipsilateral transverse foramina and their areas calculated. Complete posterior bridges occurred in 14.6% and 13.6% on the right and left sides respectively. The lateral bridge was found in 3.9% of the cases on the right side only. The complete posterior bridges had a cross-sectional area of 23.44mm2 on the right and 24.98mm2 on the left side. The lateral bridges had a mean cross-sectional area of 27.30mm2. The right and left transverse foramina had mean crosssectional area of 36.30mm2 and 37.20mm2 respectively, which was significantly larger than that of the ipsilateral complete and posterior bridges. The smaller dimensions of the complete atlas bridges compared to the ipsilateral transverse foramen suggest that they may predispose to vertebrobasilar insufficiency, Barre-Lieou and cervicogenic syndromes due to compression of the contents in the foramina.

  5. Issues in the differential diagnosis of benign liver lesions

    International Nuclear Information System (INIS)

    Full text: Recent advances in diagnosis of focal liver lesions enabled better diagnosis of benign liver lesions. Genetic changes in benign lesions enabled better understanding of benign lesions. Most common benign lesions are hemangioma, focal nodular hyperplasia and hepatic adenoma. Hepatocyte specific contrast agents are important for differential diagnosis of focal nodular hyperplasia and hepatic adenoma. Different types of hepatic adenoma (steatotic, inflammatory and malignant types) can have different radiologic findings which can be important for management and treatment planning. Presence of fat and scar within benign lesions and contrast enhancement features will be discussed. Diffusion weighted imaging findings will be reviewed

  6. Effective Border Detection of Noisy Real Skin Lesions for Skin Lesion Diagnosis by Robust Segmentation Algorithm

    OpenAIRE

    Jaseema Yasmin, J. H.; Mohamed Sathik, M.; Zulaikha Beevi, S.

    2010-01-01

    One of the most important steps in image analysis is the automated detection of lesion borders. Early detection of melanoma is one of the greatest challenges of dermatological practice today. Accurate image segmentation of skin lesions is one of the key steps for useful, early, and non-invasive diagnosis of coetaneous melanomas. The medical images generally are bound to contain noise while acquisition. This paper proposes a robust and efficient image segmentation algorithm to extract the true...

  7. [Color Doppler sonography of focal abdominal lesions].

    Science.gov (United States)

    Licanin, Zoran; Lincender, Lidija; Djurovi?, V; Salihefendi?, Nizama; Smajlovi?, Fahrudin

    2004-01-01

    Color Doppler sonography (CDS--spectral, color and power), harmonic imaging techniques (THI, PHI), possibility of 3D analysis of picture, usage of contrast agents, have raised the values of ultrasound as a diagnostic method to a very high level. THI--non-linear gray scale modality, is based on the processing of higher reflected frequencies, that has improved a picture resolution, which is presented with less artifacts and limiting effects of obesity and gases. Ultrasound contrast agents improve analysis of micro and macro circulation of the examined area, and with the assessment of velocity of supply in ROI (wash in), distribution and time of signal weakening (wash out), are significantly increasing diagnostic value of ultrasound. Besides the anatomical and topographic presentation of examined region (color, power), Color Doppler sonography gives us haemodynamic-functional information on vascularisation of that region, as well as on pathologic vascularisation if present. Avascular aspect of a focal pathologic lesion corresponds to a cyst or haematoma, while coloration and positive spectral curve discover that anechogenic lesions actually represents aneurysms, pseudoaneurysms or AVF. In local inflammatory lesion, abscess in an acute phase, CDS shows first increased, and then decreased central perfusion, while in a chronic phase, a pericapsular vascularisation is present. Contribution of CDS in differentiation of hepatic tumors (hemangioma, HCC and metastasis) is very significant. Central color dots along the peripheral blood vessels and the blush phenomenon are characteristics of capillary hemangioma, peritumoral vascular ring "basket" of HCC, and "detour" sign of metastasis. The central artery, RI from 0.45 to 0.60 and radial spreading characterize FNH. Hepatic adenoma is characterized by an intratumoral vein, and rarely by a vascular hallo. Further on, blood velocity in tumor defined by Color Doppler, distinguishes malignant from benign lesion, where 40 cm/s is a rough border value. Values of DPI (Doppler perfusion index) over 0.3 and tumor index over 1.0 characterize primary, and lower values characterize secondary liver malignancies. In differentiation of benign and malign tumors of kidneys, besides the aspect of vascularisation, the maximal frequency altitude in tumor artery (the limit around 2.5 kHz) is very important. However, peripheral and penetrating blood vessels are most usually seen in RCC, less often in AML and bigger oncocytomas. CDS with contrast agent is very useful in making differential diagnosis of the focal lesions with 95% specificity for some lesions. PMID:15137225

  8. Tumefactive fibroinflammatory lesion presenting with head and neck fibrosclerosing lesions and orbital pseudotumors: a case report

    Science.gov (United States)

    2013-01-01

    Introduction Tumefactive fibroinflammatory lesion is an idiopathic fibrosclerosing disorder occurring in the head and neck region. It is one of a broad spectrum of entities named inflammatory pseudotumors and, as the name suggests, it mimics a lot of diseases such as malignancies or infections. Combined with its rarity, tumefactive fibroinflammatory lesion can be a tremendous diagnostic challenge. This case report describes a case of tumefactive fibroinflammatory lesion, which was initially thought to be peri-orbital and mandibular osteomyelitis caused by Aspergillus. A lengthy work up ensued and was required to reach the final diagnosis. Case presentation A 64-year-old Asian man with a history of diabetes mellitus and chronic kidney disease who was on hemodialysis presented with worsening exophthalmos and relapsing trismus. He was diagnosed as “mandibular osteomyelitis” about 20 years ago. Since then he had suffered chronic relapsing exophthalmos and jaw pain with numerous medical treatments. In 2011 he was diagnosed as peri-orbital and intramandibular aspergillosis because a serum Aspergillus galactomannan assay was positive. He was treated with multiple antifungal medications to no avail. A biopsy of his orbital lesions was not revealing. After repeated biopsies, we finally concluded that the patient was suffering from tumefactive fibroinflammatory lesion. Corticosteroid therapy was initiated with prompt response. Conclusions Tumefactive fibroinflammatory lesion is a rare inflammatory benign tumor, which mimics many inflammatory and neoplastic disorders. Conventional work up including biopsy may not lead to the diagnosis without understanding this entity. Awareness of this disorder will aid early diagnosis and treatment. PMID:24229059

  9. CT diagnosis of sellar and juxtasellar lesions, 3. Non-tumorous lesions

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, Tatsuya (Nagoya Univ. (Japan). Faculty of Medicine)

    1982-08-01

    A study is made of the usefulness and limitations of the CT diagnosis of sellar and juxtasellar lesions other than tumors. This study is based on 112 verified cases at Nagoya University Hospital from October, 1976, to December, 1981. The lesions included in this study are classified into four groups: vascular, inflammatory, traumatic lesion, and congenital anomaly. Although cerebral angiography is the cardinal method for the diagnosis of vascular lesions, CT is useful for the evaluation of a giant aneurysm, the localization of bleeding, or infarction by a ruptured aneurysm. Radiation brain necrosis, a special form of vascular lesion, can also be diagnosed if the critical analysis is made after previous irradiation. CT findings are helpful for the local diagnosis of acute inflammatory lesions, such as basal meningitis or abscess, but specific diagnosis is made on the basis of clinical signs and CSF study. Abnormal CT findings are obtained from a chronic inflammatory process, such as arachnoiditis adhesiva, glanuloma, or mucocele. Differential diagnosis is necessary with brain tumors. The CT findings of an arachnoid cyst are often diagnostic. Metrizamide or air cisternography, either combined with CT or without it, is important for the diagnosis of basal meningoencephalocele and hypothalamic hamaroma. Pneumocephalus and an intracranial foreign body resulting from a head injury can be diagnosed by plain skull and CT. The diagnosis of CSF leakage or prolapse cerebri associated with a skull-base fracture has been most difficult, but even it is possible by a combination of polytomography and high-resolution CT with metrizamide cisternography.

  10. Computer tomographic localization and lesion size in aphasia

    International Nuclear Information System (INIS)

    Using a microcomputer, the locus and extent of the lesions demonstrated on CT were superimposed on standardized matrices in 127 cases with various types of aphasia, to investigate the relationship between location of the lesions and types of aphasia. Main results were as follows. 1. Broca aphasics: The lesions involved rather large areas in the deep structures of the lower part of the precentral gyrus, the insula and the lenticular nucleus. Therefore, the finding was regarded as being of little localizing value. 2. Wernicke aphasics: At least 70 % of the patients had superior temporal lesions involving Wernicke's area and the subcortical lesions of the superior and middle temporal gyri. The site of the lesion corresponded roughly with that in the previous clinico-pathological reports but was indicated in a little deeper area. 3. Amnestic aphasics: The size of the lesion was smaller than any other type but the lesions were distributed throughout the left hemisphere. Amnestic asphasia was thought to be the least localizable. 4. Conduction aphasics: Most patients had lesions in the posterior speech area involving part of Wernicke's area. In particular, in more than 80 % of the conduction aphasics the lesions were revealed in the supramarginal gyrus and it's adjacent deep structures. 5. Global aphasics: In general, the size of the lesion was very large and 70 % of the global aphasics had extensive lesions involving both Broca's and Wernicke's areas. However, there were sod Wernicke's areas. However, there were some patients showing small and confined lesions. (author)

  11. Extensión del límite austral de distribución de tres especies de peces óseos tropicales en la costa de la Provincia de Buenos Aires, Argentina / Southern extension of three species of tropical bony fishes along the coast of Buenos Aires Province, Argentina

    Scientific Electronic Library Online (English)

    Andrés C, Milessi; Jorge H, Colonello; Federico, Cortés; Carlos A, Lasta; Juan A, Waessle; Lucrecia, Allega.

    1061-10-01

    Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Se presentan tres nuevos registros de especies de peces óseos cuya distribución corresponde a aguas tropicales, capturados por buques pesqueros en la costa de la Provincia de Buenos Aires, Argentina (CPBA, 36°-38°S). Los ejemplares corresponden a las especies: Rachycentrum canadum, Elops saurus y Ca [...] ulolatilus chrysops. Estos registros amplían significativamente el límite austral de su distribución. La presencia ocasional de estas especies está asociada al transporte de agua subtropical cálida proveniente de la plataforma continental brasilera. Esta hipótesis es probada mediante el análisis de imágenes satelitales de temperatura superficial del mar. Abstract in english We document the southern records of three species of tropical bony fishes along the coast of Buenos Aires Province, Argentina (CBAP, 36-38°S). Rachycentrum canadum, Elops saurus and Caulolatilus chrysops were caught by bottom-trawl commercial vessels. Records presented here significantly extend sout [...] hward their latitudinal distribution from those previously reported. Using sea surface temperature satellite images we show a southward warm circulation event from Brazil as a putative factor to explain the occurrence of these bony fishes in the CBAP.

  12. Lesion Border Detection in Dermoscopy Images

    CERN Document Server

    Celebi, M Emre; Schaefer, Gerald; Stoecker, William V; 10.1016/j.compmedimag.2008.11.002

    2010-01-01

    Background: Dermoscopy is one of the major imaging modalities used in the diagnosis of melanoma and other pigmented skin lesions. Due to the difficulty and subjectivity of human interpretation, computerized analysis of dermoscopy images has become an important research area. One of the most important steps in dermoscopy image analysis is the automated detection of lesion borders. Methods: In this article, we present a systematic overview of the recent border detection methods in the literature paying particular attention to computational issues and evaluation aspects. Conclusion: Common problems with the existing approaches include the acquisition, size, and diagnostic distribution of the test image set, the evaluation of the results, and the inadequate description of the employed methods. Border determination by dermatologists appears to depend upon higher-level knowledge, therefore it is likely that the incorporation of domain knowledge in automated methods will enable them to perform better, especially in ...

  13. Proteome profiling of human cutaneous leishmaniasis lesion.

    Science.gov (United States)

    da Silva Santos, Claire; Attarha, Sanaz; Saini, Ravi Kanth; Boaventura, Viviane; Costa, Jackson; Khouri, Ricardo; Barral-Netto, Manoel; Brodskyn, Cláudia Ida; Souchelnytskyi, Serhiy

    2015-02-01

    In this study, we used proteomics and biological network analysis to evaluate the potential biological processes and components present in the identified proteins of biopsies from cutaneous leishmaniasis (CL) patients infected by Leishmania braziliensis in comparison with normal skin. We identified 59 proteins differently expressed in samples from infected and normal skin. Biological network analysis employing identified proteins showed the presence of networks that may be involved in the cell death mediated by cytotoxic T lymphocytes. After immunohistochemical analyses, the expression of caspase-9, caspase-3, and granzyme B was validated in the tissue and positively correlated with the lesion size in CL patients. In conclusion, this work identified differentially expressed proteins in the inflammatory site of CL, revealed enhanced expression of caspase-9, and highlighted mechanisms associated with the progression of tissue damage observed in lesions. PMID:25207817

  14. Double suture technique to delineate PASTA lesions.

    Science.gov (United States)

    Sperling, John W; Dahm, Diane L

    2006-06-01

    A common method of treating PASTA (partial articular surface tendon avulsion) lesions involves completing the tear followed by arthroscopic repair. Frequently, the boundaries of the tear are difficult to determine from the bursal side with the use of a single marking stitch. Therefore, we describe a simple technique that allows the surgeon to reproducibly define the boundaries of the partial tear. Following a standard arthroscopic examination of the articular portion of the shoulder joint, the PASTA lesion is identified. A spinal needle is introduced and the most anterior and posterior aspects of the tear are marked by passing 2 sutures. Following a bursectomy, the 2 sutures that clearly define the boundaries of the tear are identified. The tear is then completed by "connecting the dots" outlined by the sutures and an arthroscopic repair is performed in the standard manner. PMID:16762713

  15. Stereotactic biopsy of intracranial space occupying lesions

    International Nuclear Information System (INIS)

    The results of stereotactic biopsies of intracranial expanding lesions with narrow instruments both prior to and during the CT era are evaluated in 345 patients. Eighty-four cystic lesions were needled and roughly classified. Small, cystic, or solid tumours in anatomically well-defined areas such as the sellar, the third ventricle, and the pineal regions were as easily punctured and classified without as with CT scanning. When larger tumours in different compartments were punctured the biopsy verification rate increased from 55% towards 91% if an enhanced CT investigation was included. A stereotactic biopsy is a fairly safe procedure, yielding in this series a mortality less than 1% and a morbidity of 2.3%. (Author)

  16. Nontraumatic focal lesions of the spleen

    International Nuclear Information System (INIS)

    One hundred fourteen cases of nontraumatic splenic disease were reviewed to evaluate the roles of clinical findings, CT, US, and radionuclide imaging in diagnosis and management. Patient groups included lymphoma (36), infarct (28), leukemia (14), abscess (13), cyst (18), metastatic cancer (six), hemangioma (four), hematoma (four), and hamartoma (one). In no case were clinical findings alone sufficient to diagnose a splenic lesion. Clinical and laboratory manifestations were nonspecific in all groups. Moreover, no radiologic study reliably diagnosed splenic lymphoma or leukemia. All other focal splenic lesions were consistently diagnosed noninvasively. Cross-sectional imaging was more useful than radioisotope imaging and often provided adjunctive diagnosis of extrasplenic pathology. The superior detail, spatial resolution, and sensitivity of CT made it the single most valuable diagnostic modality

  17. Isolated muscular sarcoidosis mimicking a tumoral lesion

    Directory of Open Access Journals (Sweden)

    F. Tramontana

    2011-09-01

    Full Text Available We report a case of a woman with a palpable painful nodule on her left leg. MR and CT showed a lesion that could be described as a neoplasm. Excisonal biopsy revealed a noncaseating granuloma. The woman presented the nodular type of muscular isolated sarcoidosis. Further the disease involved the lungs; this confirmed the accurate diagnosis of sarcoidosis. Sarcoidosis is a chronic, multisystem granulomatous disease of unknown etiology. Muscle involvement is frequent, but often asymptomatic. There are three forms of muscular sarcoidosis: only the nodular type can be recognized by technical imaging. MR and ultrasound are the best methods to attempt the diagnosis of nodular muscular sarcoidosis; nevertheless, the lesion must have a standardized behaviour because it can mimic a malignant neoform. In this case, biopsy is the only tool to identify the disease.

  18. Neurosonography of cranial lesions in infants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Young Seok; Lee, Sung Sik; Lee, Soon Il [Sowha Children' s Hospital, Seoul (Korea, Republic of); Lee, Seung Ro [Hanyang University College of Medicine, Seoul (Korea, Republic of); Chi, Je Geun [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1986-04-15

    Since early 1980's, high resolution ultrasound has been world-widely used for detection of cranial lesions in infants but not widely used in Korea. Authors prospectively analysed ultrasonographic findings of 107 cases which were confirmed by CT, autopsy or follow-up studies as supplement. The distribution of 107 cases was intracranial hematoma 40 cases, hydrocephalus 36 cases, hypoxic-ischemic encephalopathy 10 cases, porencephalic cyst 5 cases, cephalhematoma 5 case, agenesis of corpus callosum 4 cases, medulloblastoma 2 cases and each one case of A-V malformation, intraventricular cyst, Dandy Walker cyst, lipoma and hydranencephaly. We could conclude that neurosonography of infants was very useful and effective method in detection of cranial lesions such as intracranial hematoma, especially germinal matrix hemorrhage or intraventricular hemorrhage in preterm infant, hydrocephalus, hypoxic-ischemic encephalopathy and congenital anomalies.

  19. Neurosonography of cranial lesions in infants

    International Nuclear Information System (INIS)

    Since early 1980's, high resolution ultrasound has been world-widely used for detection of cranial lesions in infants but not widely used in Korea. Authors prospectively analysed ultrasonographic findings of 107 cases which were confirmed by CT, autopsy or follow-up studies as supplement. The distribution of 107 cases was intracranial hematoma 40 cases, hydrocephalus 36 cases, hypoxic-ischemic encephalopathy 10 cases, porencephalic cyst 5 cases, cephalhematoma 5 case, agenesis of corpus callosum 4 cases, medulloblastoma 2 cases and each one case of A-V malformation, intraventricular cyst, Dandy Walker cyst, lipoma and hydranencephaly. We could conclude that neurosonography of infants was very useful and effective method in detection of cranial lesions such as intracranial hematoma, especially germinal matrix hemorrhage or intraventricular hemorrhage in preterm infant, hydrocephalus, hypoxic-ischemic encephalopathy and congenital anomalies.

  20. Causes and strategies for moisture lesions.

    Science.gov (United States)

    Bianchi, Janice

    Moisture lesions or incontinence-associated dermatitis are painful and distressing consequences of prolonged exposure to urine and faeces. They may adversely affect patients' physical and psychological wellbeing, so minimising damage is a vital part of the nurse's role. This article outlines their causes and strategies to prevent and treat them, as well as the causes of urinary and faecal incontinence and containment options. PMID:22439508

  1. Hyperdense lesions in CT of cerebral toxoplasmosis

    International Nuclear Information System (INIS)

    We report a case of cerebral toxoplasmosis in a patient with stage IV C1 AIDS who presented hyperdense CT images 13 days after beginning antitoxoplasma treatment. These lesions could be caused by calcifications or blood. The attenuation values lead us to believe that they are calcium. Intracranial calcification in adult cerebral toxoplasmosis is an uncommon finding. Its presence in AIDS patients should not suggest any etiology other than toxoplasmosis. (Author) 16 refs

  2. Computed tomography of spinal lesions in children

    International Nuclear Information System (INIS)

    Computed tomographic (CT) examination of the spinal canal is of considerable importance in children, and usually requires the use of metrizamide for good anatomical detail. The majority of abnormalities in children are congenital, and usually associated with dysraphism, Chiari malformation, or scoliosis. Tumors are the next most common diagnosis. CT with metrizamide will demonstrate the full extent of most lesions, sometimes will give information as to tissue diagnosis, and will visualize low concentrations of contrast not seen on conventional myelography. (Auth.)

  3. Computed tomography of 'cystic' intramedullary lesions

    International Nuclear Information System (INIS)

    Using an EMI 5005 scanner with high resolution option, 75% of syrinxes were shown as low density cavities. Most spinal cord tumours caused isodense swellings, but 41% contained low density zones and cystic elements were demonstrated in 76% of these at surgery or by puncture of the spinal cord, a few (11%) of the isodense tumours were cystic. The differential diagnosis of low density intramedullary lesions is discussed. (orig.)

  4. Mediastinal Cystic Lesions; Experience of 77 Patients

    Directory of Open Access Journals (Sweden)

    Koray Aydogdu

    2012-09-01

    Full Text Available Aim: Cystic lesions of the mediastinum are rare. Most of them are congenital lesions and account for 20% to 30 % of all primary masses of the mediastinum. A retrospective study of primary mediastinal cystic lesions (PMCL was conducted to review their clinical, radiological, and pathological features, as well as the early and long-term results of surgical management.Material and Method: From January 1998 through July 2008, 77 patients—47 females and 30 males, aged 4–81 years—with PMCL were treated in our department. All of the patients were analysed acording to the age, gender, symptoms, types of cysts and type of surgery. Results: There were thirty male patients (40 %, aged 4–81 years with a mean age of 39.2, and forty-seven female (60 % patients, aged 16–65 with a mean age of 35.8. Some of the patients’ pathology slides who were diagnosed as benign cysts before are re-examined then reclassified with the new diagnosis. There were thirty-one bronchogenic cysts (44 %; 19 female, 12 males, eighteen  pericardial coelomic cysts (24 %; 7 female, 11 male, five mediastinal hydatid cysts (6 %; 4 female, 1 male, five enterogenous cysts (6 %; 3 female, 2 male,  eight thymic cysts (10 %; 7 female, 1 male, two cystic lymphangiomatosis (4 %; 1 female, 1 male, five teratogenous cysts (6 %;  4 female, 1 male, and three pleural cysts (2 female, 1 male. The main symptoms were pain, fever, dyspnea, and coughing. Twenty-three patients (30 % were asymptomatic. All of the patients underwent surgery. Mean stay in the hospital was 8 days. We did not have any deaths. Discussion: Most of the patients with PMCL were female. Most of the PMCL were foregut lesions. Despite varied location and histology, the clinical presentation of mediastinal cysts was similar. Surgery provides the best chance for cure in all cases of PMCL.

  5. A More Common Mucocutaneous Lesion : Pemphigus

    OpenAIRE

    Padmakumar, S. K.; Sunil, S.

    2011-01-01

    Pemphigus is a group of potentially life-threatening disease characterized by cutaneous and mucosal blistering. There is a fairly strong genetic background to pemphigus with linkage to HLA class II alleles. Pemphigus vulgaris (PV), the most common and important variant, is an autoimmune blistering disease characterized by circulating pathogenic IgG antibodies against desmoglein 3 and desmoglein 1 autoantibodies. Oral lesions are initially vesiculobullous but readily rupture, new bullae develo...

  6. Pemphigus vulgaris presenting with multiple lesion morphologies.

    Science.gov (United States)

    Song, Philip In; Divito, Sherrie J; Kroshinsky, Daniela

    2014-01-01

    Pemphigus vulgaris is an uncommon intraepidermal blistering disorder that typically presents with flaccid bullae or erosions. We report a patient with pemphigus vulgaris who presented with several unusual clinical features: tense bullae with dependently layered pus, true target lesions coalescing into annular configurations, and diffuse desquamation that initially raised concern for toxic epidermal necrolysis. We discuss the differential diagnosis and implications of these morphological findings. PMID:25780973

  7. Tendon lesion and VEGF-111 injection

    OpenAIRE

    Kaux, Jean-franc?ois; Drion, Pierre; Libertiaux, Vincent; Pascon, Fre?de?ric; Colige, Alain; Le Goff, Caroline; Lambert, Charles; Janssen, Lauriane; Nusgens, Betty; Gothot, Andre?; Cescotto, Serge; Defraigne, Jean-olivier; Rickert, Markus; Crielaard, Jean-michel

    2010-01-01

    Introduction: Tendon lesion is one of the most frequent pathology in sports and by physical workers. This pathology often becomes chronic. For this reason, it is of interest to develop new treatments. Injection of platelet-rich plasma (PRP) seems to be a promising one by releasing growth factors (GF) locally. Among all the GF released by activated platelets, the vascular endothelial growth factor-A (VEGF-A) is known to induce positive effects on vascular function and angiogenesis, and could b...

  8. Myofibroblasts in oral lesions: A review

    OpenAIRE

    Pinisetti, Soujanya; Manyam, Ravikanth; Suresh, Babburi; Aparna, V.

    2014-01-01

    Myofibroblasts (MFs) are modified fibroblasts that express features of smooth muscle differentiation and were first observed in granulation tissue during wound healing. These cells play a key role in physiologic and pathologic processes like wound healing and tumorigenesis. The presence of MFs has been reported in normal oral tissues and pathologic conditions like reactive lesions, benign tumors, locally aggressive tumors and malignancies affecting the oral cavity. This article briefly review...

  9. Dural lesions mimicking meningiomas: A pictorial essay

    Directory of Open Access Journals (Sweden)

    Danai Chourmouzi

    2012-01-01

    Full Text Available The purpose of this essay was to illustrate the radiological and pathological findings in a wide spectrum of dural lesions mimicking meningiomas. Familiarity with and knowledge of these findings will narrow the differential diagnosis and provide guidance for patient management. In this pictorial review, we describe the following entities: Solitary fibrous tumors, hemangiopericytoma, gliosarcoma, leiomyosarcoma, dural metastases, Hodgkin’s disease, plasmocytoma, Rosai-Dorfman disease, neurosarcoidosis, melanocytic neoplasms and plasma cell granuloma.

  10. Expression of adhesion molecules in leprosy lesions.

    OpenAIRE

    Sullivan, L.; Sano, S.; Pirmez, C.; Salgame, P.; Mueller, C.; Hofman, F.; Uyemura, K.; Rea, T. H.; Bloom, B. R.; Modlin, R. L.

    1991-01-01

    Leprosy presents as a clinical spectrum that is precisely paralleled by a spectrum of immunological reactivity. The disease provides a useful and accessible model, in this case in the skin, in which to study the dynamics of cellular immune responses to an infectious pathogen, including the role of adhesion molecules in those responses. In lesions characterized by strong delayed-type hypersensitivity against Mycobacterium leprae (tuberculoid, reversal reaction, and Mitsuda reaction), the overl...

  11. Diverse Imaging characteristics of a mandibular intraosseous vascular lesion

    Energy Technology Data Exchange (ETDEWEB)

    Handa, Hina; Naidu, Giridhar S.; Dara, Balaji Gandhi Babu; Deshpande, Ashwini; Raghavendra, Raju [Peoples Dental Academy, Bhopal (Iran, Islamic Republic of)

    2014-03-15

    Intraosseous vascular lesions of the maxillofacial region are rare, and the differential diagnosis of intraosseous vascular malformations from other jaw lesions can be challenging. In the present case, magnetic resonance imaging and three-dimensional computed tomographic angiography (CTA) was used for diagnosis, and the lesion was treated with surgical excision. Diverse characteristics such as the 'honeycomb' and 'sunburst' radiographic appearances and the absence of major peripheral feeder vessels in the CTA were noted. Intraosseous vascular malformations have a varied radiographic appearance, and the nomenclature of these lesions is equally diverse, with several overlapping terms. Pathologists do not generally differentiate among intraosseous vascular lesions on the basis of histopathology, although these lesions may present with contrasting immunohistochemical and clinical behaviors requiring varied treatment strategies. This case report highlights the need for multiple imaging modalities to differentiate among vascular lesions, as well as to better understand the behaviors of these unique lesions.

  12. Selective endoscopic ligation for treatment of upper gastrointestinal protuberant lesions

    Directory of Open Access Journals (Sweden)

    Lin Wang

    2013-01-01

    Full Text Available This study explored the clinical value of endoscopic ligation for the treatment of upper gastrointestinal (GI protuberant lesions in children. According to the appearance and size of lesions, we used different ligation techniques for the treatment of the lesions. Endoscopic ultrasonography was used for preliminary characterization of the lesions. One case diagnosed with Peutz-Jeghers syndrome was successfully treated by a detachable snare. Two cases with semi-pedunculated or broad-base lesions originating from the submucosal layer of the upper GI were treated with endoscopic variceal ligation; endoscopic examination showed that one case had complete healing 11 wk after ligation, while an ulcer scar was observed at the ligation site after 6 wk in the other case. All lesions were successfully ligated at the first attempt. No significant complications occurred either during or after the procedure. Selective endoscopic ligation of upper GI lesions is an effective and safe treatment for upper GI protuberant lesions in children.

  13. Diverse Imaging characteristics of a mandibular intraosseous vascular lesion

    International Nuclear Information System (INIS)

    Intraosseous vascular lesions of the maxillofacial region are rare, and the differential diagnosis of intraosseous vascular malformations from other jaw lesions can be challenging. In the present case, magnetic resonance imaging and three-dimensional computed tomographic angiography (CTA) was used for diagnosis, and the lesion was treated with surgical excision. Diverse characteristics such as the 'honeycomb' and 'sunburst' radiographic appearances and the absence of major peripheral feeder vessels in the CTA were noted. Intraosseous vascular malformations have a varied radiographic appearance, and the nomenclature of these lesions is equally diverse, with several overlapping terms. Pathologists do not generally differentiate among intraosseous vascular lesions on the basis of histopathology, although these lesions may present with contrasting immunohistochemical and clinical behaviors requiring varied treatment strategies. This case report highlights the need for multiple imaging modalities to differentiate among vascular lesions, as well as to better understand the behaviors of these unique lesions.

  14. Transarterial embolization in head and neck lesions

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Kee Hyun; Han, Man Chung [College of Medicine, Seoul National University, Seoul (Korea, Republic of)

    1985-06-15

    The transarterial embolization procedures have been performed in a total of 38 patients with head and neck lesions, including 5 carotid-cavernous fistulas, 1 internal carotid aneurysm, 10 meningiomas, 16 nasopharyngeal angiofibromas, 1 post-traumatic epistaxis and 5 other vascular tumors, over the 18 months-period. Six cases of C-C fistula and ICA aneurysm were treated with the detachable balloon catheter technique. The meningiomas, angiofibromas and all other lesions were embolized with superselection of the branches of the external carotid artery such as the internal maxillary, the middle meningeal, the ascending pharyngeal the facial or other branches, using Berenstein superselective catheters or conventional angiographic catheters. The PVA (polyvinyl alcohol foam) and/or Gelfoam particles were used as embolic materials in these cases. Most of the lesions were successfully embolized with minor transient complications such as pain, headache, vomiting, fever and etc. But in 4 cases occurred the serious complications; one cerebral hemorrhage, two cerebral infarctions, and one acute laryngeal edema. The selection of the embolic materials and the catheters, and the complications are briefly discussed.

  15. Transarterial embolization in head and neck lesions

    International Nuclear Information System (INIS)

    The transarterial embolization procedures have been performed in a total of 38 patients with head and neck lesions, including 5 carotid-cavernous fistulas, 1 internal carotid aneurysm, 10 meningiomas, 16 nasopharyngeal angiofibromas, 1 post-traumatic epistaxis and 5 other vascular tumors, over the 18 months-period. Six cases of C-C fistula and ICA aneurysm were treated with the detachable balloon catheter technique. The meningiomas, angiofibromas and all other lesions were embolized with superselection of the branches of the external carotid artery such as the internal maxillary, the middle meningeal, the ascending pharyngeal the facial or other branches, using Berenstein superselective catheters or conventional angiographic catheters. The PVA (polyvinyl alcohol foam) and/or Gelfoam particles were used as embolic materials in these cases. Most of the lesions were successfully embolized with minor transient complications such as pain, headache, vomiting, fever and etc. But in 4 cases occurred the serious complications; one cerebral hemorrhage, two cerebral infarctions, and one acute laryngeal edema. The selection of the embolic materials and the catheters, and the complications are briefly discussed

  16. CT images of unilateral sinus lesions

    International Nuclear Information System (INIS)

    Computed tomographic images of 49 cases of unilateral sinus lesions were examined, and 4 findings were obtained as follows; 1) On the C.T. images of malignant tumors, detection of bone destruction was easy, but its early erosion was difficult. 2) Fungus infections and papilloma of paranasal sinuses demonstrated bone thickness as well as destruction, and this finding would serve as a differential point from malignant diseases. 3) From the C.T. values of soft tissue shadows in the maxillary sinus, it was impossible to differentiate malignant from benign lesions. However, a calcified or non-homogenous soft tissue shadow was seen only in cases of fungus infections and maxillary adenocarcinoma in malignant tumors, and it would be clinically a very important differential point. 4) Many of the unilateral sinus lesions will prove to be indications for surgery, except acute and allergic sinusitis. The paranasal C.T. examinations should be performed if the case does not respond to a conservative therapy over a month, and a case showing bone destruction by the C.T. images would require an exploratory Caldwell-Luc operation. (author)

  17. Intracranial lesions in dogs with hemangiosarcoma

    International Nuclear Information System (INIS)

    A retrospective analysis of 85 dogs with hemangiosarcoma (HSA) that underwent complete necropsy, including gross examination of the brain, was conducted. Grossly identifiable intracranial lesions were present in 17 dogs. Twelve of 85 dogs (14.2%) had brain metastases. Four of 85 dogs (4.7%) had hemorrhagic lesions and/or ischemic necrosis without identifiable tumor. One dog had a primary central nervous system tumor. Signs of intracranial disease were present in six of 85 dogs (7.1%) with HSA; four had brain metastases and two had nonneoplastic lesions. Metastases had a propensity for cerebrum and gray matter. Dogs with brain metastases had more widely disseminated disease than dogs without brain metastases (P less than 0.001). Dogs with pulmonary metastases were at greater risk for developing brain metastases than dogs without pulmonary metastases (odds ratio = 8.31). Although thoracic radiography accurately identified ten of 12 dogs (83%) with pulmonary metastases, too few cases were available to assess the applicability/accuracy of thoracic radiography in predicting the presence or absence of brain metastases in dogs with malignancy and signs of intracranial disease

  18. Radiological appearances of papillary breast lesions

    Energy Technology Data Exchange (ETDEWEB)

    Brookes, M.J. [Sir Charles Gairdner Hospital, Nedlands, Perth, Western Australia (Australia)], E-mail: mattbrookes@doctors.org.uk; Bourke, A.G. [Sir Charles Gairdner Hospital, Nedlands, Perth, Western Australia (Australia)

    2008-11-15

    This review illustrates the varied appearances of benign and malignant papillary breast tumours, as identified by a breast cancer-screening programme. The commonest mammographic appearance of a papillary tumour is as a soft-tissue mass, with calcification present in less than half of cases. When calcification is present the pattern is variable, but clusters of pleomorphic calcification can occur, sometimes resembling the mammographic appearance of invasive ductal carcinoma. Ultrasonography of papillary lesions typically shows a solid, oval, intraductal mass, often associated with duct dilatation. A cystic component is also commonly seen, and lesions may appear hypervascular on colour Doppler ultrasound. Magnetic resonance imaging (MRI) has a high sensitivity, but low specificity for detecting papillary tumours, and is useful in establishing the extent and distribution of lesions in patients with multiple papillomatosis. Despite a benign histology on core biopsy, an argument exists for complete surgical excision of all papillary tumours, as a significant proportion of papillomas will contain foci of atypia or overt malignant change.

  19. Oral lesions in Saudi renal transplant patients

    Directory of Open Access Journals (Sweden)

    Al-Mohaya Maha

    2009-01-01

    Full Text Available Renal transplantation has evolved as the best treatment option for patients with end-stage renal disease. Different oral problems arise in these patients, either as a direct consequence of drug-induced immunosuppression or pharmacokinetics. To determine the prevalence of intra-oral lesions in a group of medically stable Saudi renal transplant patients (RTP and to identify possible risk factors, in comparison with age and sex-matched healthy control subjects (HCS, we studied 58 RTP and 52 HCS. All subjects had a thorough oral examination and oral lesions were diagnosed according to the clinically accepted criteria. Gingival overgrowth (GO, erythematous candidiasis (EC and hairy leukoplakia (HL were diagnosed in RTP with prevalence of 74.1%, 15.5%, and 8.6%, respectively. The severity of the gingival overgrowth significantly correlated with the use of cyclosporine and nifedipine combination therapy, serum cyclosporine, and serum creatinine level. In conclusions, the finding of our study strongly propose that RTP should undergo routine and regular comprehensive oral examination, and any suspicious lesion must be investigate and treated.

  20. Ultrasonography of anterior abdominal wall lesion

    International Nuclear Information System (INIS)

    The anterior abdominal wall has received little attention in the ultrasonic evaluation. However recently the improved resolution of ultrasound scanning devices has made possible routine examination of the anterior abdominal wall. The authors evaluated ultrasonographic findings of anterior abdominal wall lesions in 27 cases for 1 year(from July '82 to Aug. '83), which were finally diagnosed pathologically and clinically. The results were as follows: 1. Well defined peritoneal line and layers of the anterior abdominal wall made it possible to localize the lesions accurately from adjacent structures. 2. Abscess and hematoma were lower in echogenecity than adjacent tissues, such as muscle layer or subcutaneous fat space and were well delineated from normal structures. 3. In hernia, easy differentiation was made due to oval shape, poor or decreased echo pattern and protrustion from skin layer. Conclusively, in the doubtful cases of palpable mass in the abdominal wall, postoperative complications of sequele, such as accurately but also the guide of treatment. Ultrasonography of anterior abdominal wall is useful to demonstrate the exact location, extent of the lesions and to decrease the frequency of useless laparatomy