WorldWideScience
 
 
1

Sclerotic lesions of the cervical spine in sarcoidosis  

Energy Technology Data Exchange (ETDEWEB)

Sarcoidosis is a common multisystem disorder characterized by noncaseating epithelial granulomata, with osseous involvement typically seen in 5% of patients. While the lace-like or cystic pattern frequently seen in radiographs of the phalanges is well appreciated, sclerotic lesions of the spine are uncommon. We review a case of sarcoidosis of the cervical spine with sclerotic changes that mimicked blastic metastatic disease. (orig.) With 1 fig., 11 refs.

Jelinek, J.S. [Department of Radiology, Washington Hospital Center, DC (United States)]|[Uniformed Services University of Health Sciences, Bethesda, MD (United States); Mark, A.S. [Department of Radiology, Washington Hospital Center, DC (United States)]|[Department of Radiology, George Washington University, DC (United States); Barth, W.F. [Section of Rheumatology, Washington Hospital Center, DC (United States)

1998-12-01

2

Bony Lesions in Pediatric Acute Leukemia: Pictorial Essay  

Directory of Open Access Journals (Sweden)

Full Text Available Acute leukemia is the most common malignancy in childhood, which mainly involves children less than 15 years of age. The growing skeleton is the main site of involvement in children. Leukemic cells proliferate within the massive red bone marrow in children. So besides the pallor, petechia, purpura and ecchymosis in the skin and mucosal surfaces, bone pain and other bony lesions are other manifestations of leukemia.On the other hand, bony lesions are more prevalent in children than adults with no poor prognosis in comparison to patients without bone lesions. These bony lesions may precede other laboratory tests so familiarity with these presentations is very important for earlier diagnosis.In this pictorial essay, we tried to gather the most common bony lesions that may be seen in acute leukemia in different cases admitted to our hospital with general malaise and localized tenderness and discomfort leading us to perform plain X-ray for further evaluation. Finding these bony lesions helps clinicians to reach the diagnosis quickly. These findings include metaphyseal lucent band and erosion, periosteal reaction, small lucent bone lesion and permeative appearance, reduced bone density and collapsed vertebra.

Makhtoom Shahnazi; Alireza Khatami; Bibishahin Shamsian; Mastooreh Mehrafarin

2012-01-01

3

Parietal Epithelial Cells Participate in the Formation of Sclerotic Lesions in Focal Segmental Glomerulosclerosis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The pathogenesis of the development of sclerotic lesions in focal segmental glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or parietal epithelial cells (PECs) to determine whether PECs contribute to sclerosis. In three distinct models of FSGS (5/6-nephrectomy + DOCA...

Smeets, Bart; Kuppe, Christoph; Sicking, Eva-Maria; Fuss, Astrid; Jirak, Peggy; van Kuppevelt, Toin H.; Endlich, Karlhans

4

Occult bony lesions associated with anterior cruciate ligament injury  

International Nuclear Information System (INIS)

To examine bony lesions associated with anterior cruciate ligament (ACL) injuries, magnetic resonance (MR) imaging was performed on 55 knees with ACL injuries. With respect to the period between ACL injuries and MR imaging, the knees were divided into acute (within one month), subacute (from one month to one year) and chronic (over one year) groups, containing 19, 16 and 20 knees, respectively. Occult bony lesions not shown in roentgenography were observed more frequently in the acute group (13/19) than in the other two groups (subacute group, 5/16; chronic group, 1/20), located in the lateral compartment of the knee joint. In the acute group, bony lesions had high signal intensity on T2-weighted images and low signal intensity on proton density images. In the subacute and chronic groups, bony lesions were less pronounced and had low signal intensity on T2-weighted images. These findings suggest that bony lesions are frequently associated with and occur simultaneously with ACL injury. (author).

1993-01-01

5

Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Although the presence of bone marrow lesions (BMLs) on magnetic resonance images is strongly associated with osteoarthritis progression and pain, the underlying pathology is not well established. The aim of the present study was to evaluate the architecture of subchondral bone in regions with and without BMLs from the same individual using bone histomorphometry. METHODS: Postmenopausal female subjects (n = 6, age 48 to 90 years) with predominantly medial compartment osteoarthritis and on a waiting list for total knee replacement were recruited. To identify the location of the BMLs, subjects had a magnetic resonance imaging scan performed on their study knee prior to total knee replacement using a GE 1.5 T scanner with a dedicated extremity coil. An axial map of the tibial plateau was made, delineating the precise location of the BML. After surgical removal of the tibial plateau, the BML was localized using the axial map from the magnetic resonance image and the lesion excised along with a comparably sized bone specimen adjacent to the BML and from the contralateral compartment without a BML. Cores were imaged via microcomputed tomography, and the bone volume fraction and tissue mineral density were calculated for each core. In addition, the thickness of the subchondral plate was measured, and the following quantitative metrics of trabecular structure were calculated for the subchondral trabecular bone in each core: trabecular number, thickness, and spacing, structure model index, connectivity density, and degree of anisotropy. We computed the mean and standard deviation for each parameter, and the unaffected bone from the medial tibial plateau and the bone from the lateral tibial plateau were compared with the affected BML region in the medial tibial plateau. RESULTS: Cores from the lesion area displayed increased bone volume fraction but reduced tissue mineral density. The samples from the subchondral trabecular lesion area exhibited increased trabecular thickness and were also markedly more plate-like than the bone in the other three locations, as evidenced by the lower value of the structural model index. Other differences in structure that were noted were increased trabecular spacing and a trend towards decreased trabecular number in the cores from the medial location as compared with the contralateral location. CONCLUSIONS: Our preliminary data localize specific changes in bone mineralization, remodeling and defects within BMLs features that are adjacent to the subchondral plate. These BMLs appear to be sclerotic compared with unaffected regions from the same individual based on the increased bone volume fraction and increased trabecular thickness. The mineral density in these lesions, however, is reduced and may render this area to be mechanically compromised, and thus susceptible to attrition.

Hunter DJ; Gerstenfeld L; Bishop G; Davis AD; Mason ZD; Einhorn TA; Maciewicz RA; Newham P; Foster M; Jackson S; Morgan EF

2009-01-01

6

Injury of anterior cruciate ligament with associated bony lesions: MR image  

International Nuclear Information System (INIS)

To evaluate the characteristic MR findings in injury of the anterior cruciate ligament (ACL) with associated bony lesions. We reviewed MR findings and the corresponding arthroscopic or operative results of 48 patients with ACL injuries, and evaluated ACL signal intensity and contour. In associated bony lesions, we determined the location of avulsion fracture and bony bruise. Complete ACL tears were seen in 27 cases, partial tears in 13, and avulsion injury in eight. Complete tears showed heterogeneously increased signal intensity with contour bulging in ten cases (37%), and combined bony lesion in 14 (52%). ACL with a thin continous low signal intensity band surrounding heterogeneously-increased signal intensity suggested partial tears, and was seen in three of 13 proven cases (23%) of partial ACL tears;combined bony lesion was seen in four such cases(31%). There were eight cases of avulsion fracture;the most frequent site was the anterolateral portion of the tibial spine (n=6). The most frequent sites of bony lesion were at the midportion of the lateral femoral condyle (n=6), and the posterior portion of the lateral tibial plateau (n=6);the next most frequent site was the anterior portion of the lateral tibial plateau (n=5). Tearing of the ACL was seen on MRI as ligament discontinuity, and heterogeneously increased signal intensity with ACL contour bulging. The most frequent sites of associated bony lesions were the midportion of the lateral femoral condyle, and the posterior portion of the lateral tibial plateau. In associated bony lesions, bony contusion suggested ACL tearing, but avulsion fracture suggested ligament avulsion injury without tear.

1997-01-01

7

Injury of anterior cruciate ligament with associated bony lesions: MR image  

Energy Technology Data Exchange (ETDEWEB)

To evaluate the characteristic MR findings in injury of the anterior cruciate ligament (ACL) with associated bony lesions. We reviewed MR findings and the corresponding arthroscopic or operative results of 48 patients with ACL injuries, and evaluated ACL signal intensity and contour. In associated bony lesions, we determined the location of avulsion fracture and bony bruise. Complete ACL tears were seen in 27 cases, partial tears in 13, and avulsion injury in eight. Complete tears showed heterogeneously increased signal intensity with contour bulging in ten cases (37%), and combined bony lesion in 14 (52%). ACL with a thin continous low signal intensity band surrounding heterogeneously-increased signal intensity suggested partial tears, and was seen in three of 13 proven cases (23%) of partial ACL tears;combined bony lesion was seen in four such cases(31%). There were eight cases of avulsion fracture;the most frequent site was the anterolateral portion of the tibial spine (n=6). The most frequent sites of bony lesion were at the midportion of the lateral femoral condyle (n=6), and the posterior portion of the lateral tibial plateau (n=6);the next most frequent site was the anterior portion of the lateral tibial plateau (n=5). Tearing of the ACL was seen on MRI as ligament discontinuity, and heterogeneously increased signal intensity with ACL contour bulging. The most frequent sites of associated bony lesions were the midportion of the lateral femoral condyle, and the posterior portion of the lateral tibial plateau. In associated bony lesions, bony contusion suggested ACL tearing, but avulsion fracture suggested ligament avulsion injury without tear.

Kim, Soon; Oh, Yeon Hee; Lee, Chang Wook [Dongguk Univ. College of Medicine, Seoul (Korea, Republic of); Kim, Yong Min [Chungbuk Univ. College of Medicine, Chongju (Korea, Republic of); Lee, Hyeon Kyeong; Kim, Seung Hyeon; Lee, Sung Woo [Dongguk Univ. College of Medicine, Seoul (Korea, Republic of)

1997-05-01

8

Occult bony lesions associated with anterior cruciate ligament injury; Assessment with MR imaging  

Energy Technology Data Exchange (ETDEWEB)

To examine bony lesions associated with anterior cruciate ligament (ACL) injuries, magnetic resonance (MR) imaging was performed on 55 knees with ACL injuries. With respect to the period between ACL injuries and MR imaging, the knees were divided into acute (within one month), subacute (from one month to one year) and chronic (over one year) groups, containing 19, 16 and 20 knees, respectively. Occult bony lesions not shown in roentgenography were observed more frequently in the acute group (13/19) than in the other two groups (subacute group, 5/16; chronic group, 1/20), located in the lateral compartment of the knee joint. In the acute group, bony lesions had high signal intensity on T2-weighted images and low signal intensity on proton density images. In the subacute and chronic groups, bony lesions were less pronounced and had low signal intensity on T2-weighted images. These findings suggest that bony lesions are frequently associated with and occur simultaneously with ACL injury. (author).

Nawata, Koji; Toshima, Ryota; Yamamoto, Yoshizo (Tottori Univ., Yonago (Japan). School of Medicine); Suzuki, Toshiro; Date, Shinya

1993-09-01

9

Bony change of apical lesion healing process using fractal analysis  

Energy Technology Data Exchange (ETDEWEB)

To investigate the change of bone healing process after endodontic treatment of the tooth with an apical lesion by fractal analysis. Radiographic images of 35 teeth from 33 patients taken on first diagnosis, 6 months, and 1 year after endodontic treatment were selected. Radiographic images were taken by JUPITER computerized Dental X-ray System. Fractal dimensions were calculated three times at each area by Scion Image PC program. Rectangular region of interest (30 x 30) were selected at apical lesion and normal apex of each image. The fractal dimension at apical lesion of first diagnosis (L{sub 0}) is 0.940 {+-} 0.361 and that of normal area (N{sub 0}) is 1.186 {+-} 0.727 (p<0.05). Fractal dimension at apical lesion of 6 months after endodontic treatment (L{sub 1}) is 1.076 {+-} 0.069 and that of normal area (N{sub 1}) is 1.192 {+-} 0.055 (p<0.05). Fractal dimension at apical lesion of 1 year after endodontic treatment (L{sub 2}) is 1.163 {+-} 0.074 and that of normal area (N{sub 2}) is 1.225 {+-} 0.079 (p<0.05). After endodontic treatment, the fractal dimensions at each apical lesions depending on time showed statistically significant difference. And there are statistically significant different between normal area and apical lesion on first diagnosis, 6 months after, 1 year after. But the differences were grow smaller as time flows. The evaluation of the prognosis after the endodontic treatment of the apical lesion was estimated by bone regeneration in apical region. Fractal analysis was attempted to overcome the limit of subjective reading, and as a result the change of the bone during the healing process was able to be detected objectively and quantitatively.

Lee, Ji Min; Park, Hyok; Jeong, Ho Gul; Kim, Kee Deog; Park, Chang Seo [Yonsei University College of Medicine, Seoul (Korea, Republic of)

2005-06-15

10

Bony change of apical lesion healing process using fractal analysis  

International Nuclear Information System (INIS)

To investigate the change of bone healing process after endodontic treatment of the tooth with an apical lesion by fractal analysis. Radiographic images of 35 teeth from 33 patients taken on first diagnosis, 6 months, and 1 year after endodontic treatment were selected. Radiographic images were taken by JUPITER computerized Dental X-ray System. Fractal dimensions were calculated three times at each area by Scion Image PC program. Rectangular region of interest (30 x 30) were selected at apical lesion and normal apex of each image. The fractal dimension at apical lesion of first diagnosis (L0) is 0.940 ± 0.361 and that of normal area (N0) is 1.186 ± 0.727 (p1) is 1.076 ± 0.069 and that of normal area (N1) is 1.192 ± 0.055 (p2) is 1.163 ± 0.074 and that of normal area (N2) is 1.225 ± 0.079 (p

2005-01-01

11

CT and MRI of intrinsic space-occupying lesions of the bony skull base  

International Nuclear Information System (INIS)

Intrinsic bony lesions of the skull base are diseases which arise within the bones forming the skull base. Mainly they are bone tumours and tumour-like lesions. With the exception of osteomas of the paranasal sinuses and exostoses of the external auditory canal, these lesions occur rarely. This article gives an overview of the appearance of the most common primary bony skull base masses in CT and MRI. From the authors' point of view these are fibrous dysplasia, chordomas, chondrosarcomas, Langerhans cell histiocytosis and multiple myelomas, which must be differentiated from pseudolesions. The possibilities of CT and MRI in making a specific diagnosis, differential diagnosis and the kind of making the final diagnosis are described. (orig.)

2009-01-01

12

Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy.  

Science.gov (United States)

Growing evidence suggests that human immunodeficiency virus (HIV)-1 infection of podocytes plays a central role in the glomerular disease of HIV-associated nephropathy (HIVAN). As an approach to identify host genes involved in the pathogenesis of the sclerotic glomerular lesion in HIVAN, representational difference analysis of cDNA was used to identify differentially expressed genes in HIV-1 transgenic and nontransgenic podocytes. We isolated a novel member of the small leucine-rich repeat (SLR) protein family, podocan, that is expressed at high levels in the HIV-1 transgenic podocytes. In normal embryonic kidney, a 3.2-kb podocan transcript was detected at low levels, and expression increased dramatically within 24 h following birth. Expression of a 2.3-kb transcript became evident after birth and gradually increased to 50% of the total podocan RNA in the mature kidney. Phylogenetically, podocan represents a new class in the SLR protein gene family, an expanding protein family sharing homology with the small leucine-rich repeat proteoglycans. The 3.2-kb transcript encodes a predicted 611-amino acid secretory protein with 20 leucine-rich repeats, a unique N-terminal cysteine-rich cluster pattern and a highly acidic C-terminal domain. In situ hybridization of normal kidney revealed podocan mRNA expression in podocytes and likely vascular endothelial cells within the glomerulus. The immunohistochemical staining pattern of podocan protein in normal kidney glomeruli was consistent with that of the glomerular basement membrane, and staining was markedly increased in sclerotic glomerular lesions in the transgenic HIVAN model. Thus, podocan defines a new class within the SLR protein family and is a previously unrecognized component of the sclerotic glomerular lesion that develops in the course of experimental HIVAN. PMID:12796502

Ross, Michael D; Bruggeman, Leslie A; Hanss, Basil; Sunamoto, Masaaki; Marras, Daniele; Klotman, Mary E; Klotman, Paul E

2003-06-08

13

Bone scintigraphy may help differentiate bone sclerotic lesions from osteoblastic metastases in tuberous sclerosis patients with concomitant pulmonary adenocarcinoma.  

UK PubMed Central (United Kingdom)

Tuberous sclerosis (TS) is a multisystem disorder characterized by widespread hamartomas in multiple organs, including the skeleton. We present a case of bone involvement in a patient with TS and concomitant pulmonary adenocarcinoma. Bone scintigraphy is useful in distinguishing the TS bone lesions from osteoblastic metastases.

Song L; Zhang Y; Zhang W

2013-03-01

14

Detection of Mycobacterium tuberculosis DNA in the sclerotic spinal wall.  

UK PubMed Central (United Kingdom)

Recent studies have shown that the major spinal lesion in spinal tuberculosis is predominantly sclerotic and accounts for >70% of the lesion. In this type of sclerosis, apart from spinal reactive hyperplasia and increased bone density, the most severe lesion is the formation of a hard outer osteoid shell (the sclerotic wall) around the cheese-like substances and granulated tissues. In the current study, polymerase chain reaction detection of Mycobacterium tuberculosis in the sclerotic wall was performed. Surgical specimens were obtained from 18 patients with spinal tuberculosis with peripheral sclerotic wall (as shown by computed tomography) and included the sclerotic wall, subnormal bone tissue outside the sclerotic wall, and iliac bone tissue (control). The IS986 gene in the samples was amplified by polymerase chain reaction followed by DNA sequencing. The obtained sequences were then compared with the published sequences in GenBank using DNATools version 5.1 software (International Centre for Genetic Engineering and Biotechnology, Trieste, Italy). The polymerase chain reaction results showed that 16 specimens from the sclerotic spinal wall, 3 from the subnormal bone, and 0 from the controls were positive for M tuberculosis, indicating a statistically significant difference (P<.05). These results indicated that M tuberculosis was present in the spinal sclerotic wall. Combined with our previous studies, we conclude that the sclerotic wall should be considered a lesion in patients with spinal tuberculosis.

Si J; Geng G; Wang Z

2012-03-01

15

Sclerotic medullary spread in diaphyseal osteosarcoma.  

UK PubMed Central (United Kingdom)

Dense medullary sclerosis is reported in the shafts of long bones accompanying diaphyseal osteosarcoma. Histological evidence suggests that this indicates more extensive medullary spread of tumour than is readily apparent on standard radiographic examination. It would appear that these sclerotic lesions show active radio-isotopes retention following skeletal scintigraphy. The clinical and radiological features and prognostic implications of these findings are discussed.

Haworth JM; McCall IW; Park WM; Watt I

1979-01-01

16

Reconstruction of a bony bankart lesion: best fit based on radius of curvature.  

UK PubMed Central (United Kingdom)

BACKGROUND: The inferior coracoid process has traditionally been considered to be the gold standard for glenoid augmentation after anteroinferior bone loss. Other autograft sites, and more recently, osteochondral allograft sites, have been described as potential donor sources. PURPOSE: Potential autograft and osteochondral allograft sites were compared to identify the graft source that would provide the best fit for glenoid augmentation. STUDY DESIGN: Controlled laboratory study. METHODS: Mose circles, a geometric tool found on a standard goniometer, were used to make radius of curvature measurements of 10 anatomic locations in 17 cadaveric specimens. The bony surface of the glenoid, measured from superior to inferior (G-SI) and from anterior to posterior (G-AP), was used as the standard for comparison. Autograft sites were the inferior coracoid, lateral coracoid, and inner table of the iliac crest. Potential osteochondral allograft sites were the radial head, scaphoid fossa of the distal radius (S-DR), lunate fossa of the distal radius (L-DR), medial tibial plateau, and lateral distal tibia. An acceptable match for autograft sites was based on a paired analysis and defined as a radius of curvature within 5 mm of the G-SI or the G-AP of the same cadaveric specimen. Allograft sites were evaluated using an unpaired analysis in which an ideal fit was defined as a radius of curvature of 25 to 30 mm, based on the interquartile range of the G-SI and G-AP. RESULTS: The median (interquartile range) radii of curvature for the G-SI and G-AP were 30 mm (range, 25-30 mm) and 25 mm (range, 25-25 mm), respectively. The inferior coracoid was within 5 mm of the G-SI 59% of the time and the G-AP 94% of the time; no measurements from the lateral coracoid or iliac crest were within the range of the glenoid radius of curvature. Analysis of the allograft sites demonstrated an acceptable fit for 94% of the distal tibia, 68% of the medial tibial plateau, 12% of the S-DR, and 0% of the L-DR and the radial head specimens. CONCLUSION: An autograft of the inferior coracoid or an osteochondral allograft of the lateral distal tibia provided the best match to re-establish the native radius of curvature of the glenoid. CLINICAL RELEVANCE: To best re-create the native glenohumeral anatomy, surgeons should consider the use of an autograft of the inferior coracoid or an osteochondral allograft of the lateral distal tibia for the reconstruction of osseous glenoid defects.

Dehaan A; Munch J; Durkan M; Yoo J; Crawford D

2013-05-01

17

Bony periosteum-covered iliac crest plug transplantation for severe osteochondral lesions of the talus: a modified mosaicplasty procedure.  

UK PubMed Central (United Kingdom)

PURPOSE: This study reports first evidence of a modified procedure for osteochondral autologous transplantation where bony periosteum-covered plugs are harvested at the iliac crest and transplanted into the talar osteochondral lesion. METHODS: Thirteen out of 14 patients, average age 39.6 (SD 14.4) years, were followed clinically and radiographically for a median of 25 (24-28) months (minimal follow-up, 24 months). RESULTS: For these 13 patients, the American Orthopaedic Foot and Ankle Society hindfoot score increased from 47 (SD 11) points pre-operatively, to 81 (SD 14) points postoperatively (p < 0.0001). The average pain score decreased from 6.6 (SD 1.3) points pre-operatively, to 1.4 (SD 1.9) points postoperatively (p < 0.0001). Seven patients returned to sports activity. Radiographically good plug osteointegration was observed in nine out of 11 ankles. Follow-up arthroscopy showed fibrous cartilage in four ankles, periosteum hypertrophy in five ankles, and partial or total missing of coverage of the bone in three ankles. Three revision surgeries had to be performed. CONCLUSIONS: This modified mosaicplasty might be recommended for severe and recurrent osteochondral lesions of the talus and may lead to restoration of the subchondral bone stock, formation of fibro-cartilage, and stable joint function. LEVEL OF EVIDENCE: IV.

Leumann A; Valderrabano V; Wiewiorski M; Barg A; Hintermann B; Pagenstert G

2013-07-01

18

Sclerotic bone metastases from sarcomatoid renal cell carcinoma  

International Nuclear Information System (INIS)

We present a case of sarcomatoid renal cell carcinoma with multiple sclerotic skeletal metastatic lesions. Renal cell carcinoma is frequently metastatic at presentation, with a high incidence of skeletal involvement, classically described as osteolytic. However, sclerotic or osteoblastic metastatic skeletal lesions from renal cell carcinoma are rare, with only two previous reports identified in the literature, neither of which involved the sarcomatoid variant of renal cell carcinoma. In our case the sclerotic metastases were characterized by bone scan, computed tomography (CT), magnetic resonance imaging (MRI), and histologic analysis. (orig.)

1999-01-01

19

Sclerotic bone metastases from sarcomatoid renal cell carcinoma  

Energy Technology Data Exchange (ETDEWEB)

We present a case of sarcomatoid renal cell carcinoma with multiple sclerotic skeletal metastatic lesions. Renal cell carcinoma is frequently metastatic at presentation, with a high incidence of skeletal involvement, classically described as osteolytic. However, sclerotic or osteoblastic metastatic skeletal lesions from renal cell carcinoma are rare, with only two previous reports identified in the literature, neither of which involved the sarcomatoid variant of renal cell carcinoma. In our case the sclerotic metastases were characterized by bone scan, computed tomography (CT), magnetic resonance imaging (MRI), and histologic analysis. (orig.)

Liu, P.T. [Dept. of Diagnostic Radiology, Mayo Clinic Scottsdale, Scottsdale, AZ (United States); Conley, C.R. [Dept. of Pathology, Mayo Clinic Scottsdale, Scottsdale, AZ (United States); Callstrom, M.R. [Dept. of Diagnostic Radiology, Mayo Clinic Rochester, Rochester, MN (United States)

1999-10-01

20

Imaging spectrum in sclerotic myelomas: an experience of three cases  

Energy Technology Data Exchange (ETDEWEB)

The classic radiographic presentation of multiple myeloma is lytic skeletal lesions. Primary sclerotic manifestations are rare and occur only in 3 % of cases. The imaging spectrum in three cases of multiple myeloma with primary osteosclerosis is described. The first patient had spiculated sclerosis of the orbit, which is an uncommon site for myeloma. The second patient with POEMS syndrome had multiple, scattered, skeletal lesions with sclerotic margins. The third patient presented with a chest wall mass and had an expansile thick spiculated sclerosis in the rib. The wide imaging spectrum possible in sclerotic myelomas and their relevant differential diagnosis is emphasized. (orig.)

Grover, S.B.; Dhar, A. [Dept. of Radiology, Safdarjang Hospital, New Delhi (India)

2000-11-01

 
 
 
 
21

Absorption of the bone fragment in shoulders with bony Bankart lesions caused by recurrent anterior dislocations or subluxations: when does it occur?  

UK PubMed Central (United Kingdom)

BACKGROUND: Recently, bony defects of the glenoid in patients with traumatic anterior shoulder instability have been increasingly noticed. The bone fragment of a bony Bankart lesion is often utilized for Bankart repair, but the fragment is at times smaller than the glenoid defect. The reason for this mismatch in size is unknown. HYPOTHESIS: The bone fragment of a bony Bankart lesion might gradually be absorbed over time. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: A total of 163 shoulders were prospectively examined by computed tomography. In shoulders with bony Bankart lesions, glenoid defects and bone fragment absorption were assessed, and findings were compared with the time elapsed after the primary traumatic episode. When a bone fragment was not detected despite loss of the normal contour of the glenoid rim, the findings were classified as erosions if the rim appeared round and slightly compressed and classified as complete bone fragment absorption if the rim appeared straight and sharp. RESULTS: There were no glenoid defects in 55 shoulders, erosions in 16 shoulders, and glenoid defects in 92 shoulders. The size of the glenoid defect was 0% to 10% in 15 shoulders, 10% to 20% in 44, 20% to 30% in 26, 30% to 40% in 6, and 40% to 50% in 1. The average defect size was 7.9% in shoulders scanned at <1 year, 10.7% between 1 and 2 years, and 11.3% at >2 years, indicating no relationship with time after trauma. Regarding bone fragment absorption, all 92 shoulders with glenoid defects showed absorption to some extent. The extent of absorption was <50% in 32 shoulders, >50% in 45, and 100% in 15. The average extent of absorption was 51.9% in shoulders scanned at <1 year, 65.3% between 1 and 2 years, and 70.0% at >2 years, indicating a significant relationship with time after trauma. CONCLUSION: Bone fragment absorption was seen in all of the shoulders with bony Bankart lesions. Most bone fragments showed severe absorption within 1 year after the primary traumatic episode. Before arthroscopic Bankart repair, not only glenoid defects but also bone fragment absorption should be assessed.

Nakagawa S; Mizuno N; Hiramatsu K; Tachibana Y; Mae T

2013-06-01

22

CT and MRI of intrinsic space-occupying lesions of the bony skull base; CT und MRT bei intrinsischen raumfordernden Laesionen der knoechernen Schaedelbasis  

Energy Technology Data Exchange (ETDEWEB)

Intrinsic bony lesions of the skull base are diseases which arise within the bones forming the skull base. Mainly they are bone tumours and tumour-like lesions. With the exception of osteomas of the paranasal sinuses and exostoses of the external auditory canal, these lesions occur rarely. This article gives an overview of the appearance of the most common primary bony skull base masses in CT and MRI. From the authors' point of view these are fibrous dysplasia, chordomas, chondrosarcomas, Langerhans cell histiocytosis and multiple myelomas, which must be differentiated from pseudolesions. The possibilities of CT and MRI in making a specific diagnosis, differential diagnosis and the kind of making the final diagnosis are described. (orig.) [German] Unter intrinsischen Laesionen der knoechernen Schaedelbasis versteht man Erkrankungen, die von den die Schaedelbasis bildenden Knochen ausgehen. In erster Linie handelt es sich um Knochentumoren und tumoraehnliche Laesionen. Mit wenigen Ausnahmen (Nasennebenhoehlenosteome, Exostosen des aeusseren Gehoergangs) sind sie selten. Dieser Beitrag gibt einen Ueberblick ueber das CT- und MRT-Erscheinungsbild der aus Sicht der Autoren unter diesem Aspekt noch am haeufigsten anzutreffenden raumfordernden Laesionen. Dazu zaehlen die fibroese Dysplasie, Chordome, Chondrosarkome, die Langerhans-Zell-Histiozytose und das multiple Myelom. Abgrenzt werden muessen Pseudotumoren. Artdiagnostische Zuordnungsmoeglichkeiten durch CT und/oder MRT, Differenzialdiagnosen und Diagnosesicherung werden dargelegt. (orig.)

Koesling, S.; Brandt, S. [Martin-Luther-Universitaet Halle-Wittenberg, Universitaetsklinik und Poliklinik fuer Diagnostische Radiologie, Halle (Germany); Neumann, K. [Martin-Luther-Universitaet Halle-Wittenberg, Universitaetsklinik und Poliklinik fuer Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie, Halle (Germany)

2009-07-15

23

Localized sclerotic bone response demonstrated reduced nanomechanical creep properties.  

UK PubMed Central (United Kingdom)

Sclerosis (tissue hardening) development is a common occurrence in slow growing or benign osteolytic lesions. However, there is lack of knowledge on the mechanical and material property changes associated with sclerotic bone response. The immune system is postulated to play a relevant role in evoking sclerotic bone responses. In this study, localized sclerotic response in an immunocompetent model of Walker 256 breast carcinoma in SD rats showed an apparent increase in new reactive bone formation. Sclerotic rat femurs had significant increases in bone mineral density (BMD), bone mineral content (BMC), bone volume fraction (BV/TV), bone surface density (BS/TV), trabecular number (Tb.N) and a significant decrease in trabecular separation (Tb.Sp) and structural model index (SMI) as compared to control rat femurs. Significantly reduced creep responses (increased ?) were observed for both trabecular and cortical bone in sclerotic bones while no significant difference was observed in elastic modulus (E) and hardness (H) values. Therefore, we conclude that viscoelastic creep property using nanoindentation would serve as a more sensitive indicator of localized bone modeling than elastic properties. Moreover, reduced viscoelasticity can contribute towards increased microcrack propagation and therefore reduced toughness. Since significant positive correlations between elastic properties (E) and (H) with viscosity (?) were also observed, our results indicate that sclerotic response of bone metastasis would cause reduced toughness (increased ?) with stiffening of material (increased E and H).

Chen X; Goh JC; Teoh SH; De SD; Soong R; Lee T

2013-01-01

24

Multiple bony lesions other than femoral heads on {sup 99m}Tc-MDP bone scan in patients with avascular necrosis of the femoral head  

Energy Technology Data Exchange (ETDEWEB)

To evaluate the clinical significance of the multiple increased uptake lesions other than in femoral heads as seen on whole body bone scan in patients with avascular necrosis of femoral heads. One hundred and seventy three patients with clinical diagnosis of avascular necrosis of the emoral head underwent a bone scan using Tc-99m MDP. Increased uptake lesions other than in femoral heads were evaluated, including frequency and common sites of in volvement, and correlated with clinical information and plain radiographic findings. Two hundred patients without AVN, who had undergone a bone scan, were included as a control group. Increased uptake lesions in extrafemoral head locations were found in 36 of 173 patients(20.8%); the location of 79 lesions was other than the femoral head. This result is statistically different from patients without avascular necrosis of femoral head(p<0.0001). The most common site of involvement was the knee joint area(62.5%). Other lesions were located in the mid-shafts of the long bones of the lower extremities, calcaneus, proximal humerus, etc., in order of decreasing frequency. Plain radiographs of 17 lesions were nonspecific, except for three lesions showing definite changes associated with avascular necrosis. The risk factors included alcoholism, the prolonged use of steroids, renal transplantation, herbal medication and working as a working as deep-sea diver. Most patients did not complain of pain, except for two with irreversible osteonecrotic changes as seen on plain radiograph. in patients with avascular necrosis of the femur, increased uptake lesions other than in the femoral head as seen on bone scan, may represent the early stage of osteonecrosis, which shows a characteristic appearance on bone scan. In order to aveid possible misdiagnoses of multiple extrafemoral lesions as bony metastasis or traumatic lesions, in patients with avascular necrosis of the femur these should be carefully evaluated.

Choi, Yun Young; Yang, Seoung Oh; Moon, Dae Hyuk; Ryu, Jin Sook; Weon, Young Cheol; Shin, Myung Jin; Lee, Soo Ho; Lee, Hee Kyung [Asan Medical Center, Ulsan Univ. College of Medicine, Ulsan (Korea, Republic of); Chun, Hae Kyung [St. Francisco Hospital, Seoul (Korea, Republic of)

1997-03-01

25

Development of Natural Culture Media for Rapid Induction of Fonsecaea pedrosoi Sclerotic Cells In Vitro?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fonsecaea pedrosoi is the main agent of chromoblastomycosis, a skin disease presenting verrucous lesions, in which round, thick-walled sclerotic cells are found. In vitro induction of sclerotic cells is time-consuming (20 to 45 days) and temperature dependent. We present two new natural media that r...

da Silva, Moises Batista; da Silva, Jorge Pereira; Sirleide Pereira Yamano, Suellen; Salgado, Ubirajara Imbiriba

26

MRI findings in sclerotic bone changes  

Energy Technology Data Exchange (ETDEWEB)

We have compared the value of MRI with conventional radiography and CT in 40 predominantly sclerotic skeletal lesions. We have found that sclerosis and other changes in the bone structure can be demonstrated by MRI in much the same way as with conventional radiography and CT. Using high resolution surface coils, it is possible to demonstrate small areas of new bone formation such as periosteal new bone or the calcification within the nidus of an osteoid osteoma. MRI is particularly appropriate if it is necessary to show soft tissue changes within an area of sclerosis, which may be responsible for the new bone formation and which may be masked on radiographs and CT by the surrounding sclerosis.

Holland, B.R.; Freyschmidt, J.

1988-11-01

27

Value of Bone Scan in Addition to F-18 FDG PET/CT and Characteristics of Discordant Lesions between F-18 FDG PET/CT and Bone Scan in the Spinal Bony Metastasis  

Energy Technology Data Exchange (ETDEWEB)

Our purpose was to evaluate spinal bony metastasis which could be missed on an F-18 FDG PET/CT (FDG PET/CT) alone, and to characterize discordant metastatic lesions between FDG PET/CT and bone scan. FDG PET/CT and bone scans of 43 patients with spinal bony metastasis were analyzed retrospectively. A McNemar test was performed comparing the FDG PET/CT alone to the FDG PET/CT plus bone scan in the spinal bony metastases. A one-way chi-square test was performed to characterize the metastases that were missed on the FDG PET/CT alone. To evaluate discordant lesions between FDG PET/CT and bone scan, we performed logistic regression analyses. The independent variables were sites (cervical, thoracic, and lumbar), size (large and small), and maximum SUVs, and the dependant variable was bone scan uptake (positive and negative MDP uptake). A significant difference was found between the FDG PET/CT alone and the FDG PET/CT combined with the bone scan (p<0.01). Using the FDG PET/CT only, diffuse osteoblastic metastasis was missed with a significantly higher frequency (p=0.04). In the univariate analysis, cervical vertebra and small size were related to negative MDP uptake, and thoracic vertebra and large size were related to positive MDP uptake. However, in the multivariate analysis, only the large size was related to positive MDP uptake. A bone scan in addition to the FDG PET/CT increased the ability to evaluate spinal bony metastases, especially for diffuse osteoblastic metastasis. Large metastasis was related to positive bone scan uptake in spinal bony metastasis.

Jun, Sung Min; Nam, Hyun Yeol; Kim, In Ju; Kim, Yong Ki [Pusan National University Hospital, Pusan (Korea, Republic of); Kim, Ju Sung [College of Medical Life Science, Silla University, Pusan (Korea, Republic of)

2008-06-15

28

Value of Bone Scan in Addition to F-18 FDG PET/CT and Characteristics of Discordant Lesions between F-18 FDG PET/CT and Bone Scan in the Spinal Bony Metastasis  

International Nuclear Information System (INIS)

Our purpose was to evaluate spinal bony metastasis which could be missed on an F-18 FDG PET/CT (FDG PET/CT) alone, and to characterize discordant metastatic lesions between FDG PET/CT and bone scan. FDG PET/CT and bone scans of 43 patients with spinal bony metastasis were analyzed retrospectively. A McNemar test was performed comparing the FDG PET/CT alone to the FDG PET/CT plus bone scan in the spinal bony metastases. A one-way chi-square test was performed to characterize the metastases that were missed on the FDG PET/CT alone. To evaluate discordant lesions between FDG PET/CT and bone scan, we performed logistic regression analyses. The independent variables were sites (cervical, thoracic, and lumbar), size (large and small), and maximum SUVs, and the dependant variable was bone scan uptake (positive and negative MDP uptake). A significant difference was found between the FDG PET/CT alone and the FDG PET/CT combined with the bone scan (p

2008-01-01

29

Destructive lesion of vertebral body: CT findings and differential diagnosis of inflammation and malignancy  

International Nuclear Information System (INIS)

[en] The CT findings and their differential points were evaluated by reviewing the CT scans of 47 patients with destructive lesions of vertebral bodies which included tuberculous spondylitis(23), pyogenic infection(9), syphilitic spondylitis(1) and malignant lesion(14). Twenty-one (91.3%) of 23 patients with tuberculous spondylitis showed mixed osteolytic and osteosclerotic patterns of bony destruction. Six(66.7%) of 9 patients with pyogenic infection and 10(71.4%) of 14 malignant lesions showed osteolytic pattern of bony destruction. Thrity(90.9%) of 33 infectious lesions including pyogenic infection and tuberculous spondylitis involved intervertebral disc, while the involvement of intervertebral disc was not found in malignant lesion. The Swiss cheese appearance of bony destruction was commonly seen in tuberculous spondylitis, but pyogenic infections and malignant lesions more commonly revealed geographic or moth-eaten appearance. The sequestral pattern and sclerotic rims in and around bony destruction were mainly seen in tuberculous spondylitis, and they were thought to be specific findings in tuberculous spondylitis. CT of the spine appears to offer the detailed findings of vertebral body destruction and may be a useful adjunct in differentiation between tuberculous spondylitis, pyogenic infections and malignant lesions of the spine

1993-01-01

30

Sclerotic bodies beyond nephrogenic systemic fibrosis.  

UK PubMed Central (United Kingdom)

Sclerotic bodies are round to oval structures made up of collagen with entrapped elastic fibers, which may be sometimes ossified. These bodies may be found in skin biopsies from patients with nephrogenic systemic fibrosis (NSF), a disease linked to the use of gadolinium in radiologic procedures and chronic renal failure. Sclerotic bodies have not been reported in other diseases. Herein, we report sclerotic bodies as an incidental finding in a re-excision specimen of a squamous cell carcinoma (SCC) from the forearm of an 85-year-old man with chronic renal failure. The patient had had multiple SCC removed over time. Additional clinical history revealed patient having received gadolinium in 2003 and 2004, preceding his dialysis that began in 2009. All of his excision specimens revealed sclerotic bodies in 20 of 30 specimens from 2008. None of the 26 re-excision specimens prior to gadolinium exposure had these bodies. Our findings suggest that sclerotic bodies are the result of gadolinium exposure in patients with chronic renal insufficiency. Because the bodies were found near the re-excision scar, it may be that gadolinium or its metabolites activate fibroblasts in the setting of wound healing. The reasons why this patient did not develop NSF are unclear.

Bhawan J; Perez-Chua TA; Goldberg L

2013-09-01

31

CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS  

Directory of Open Access Journals (Sweden)

Full Text Available Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fingers have not been reported to date. Mucin deposition in the sclerotic skin may be a predisposing factor in the induction of myxoid cyst on the scleroderma finger in our patient.

Taeko Nakamura-Wakatsuki; Toshiyuki Yamamoto

2013-01-01

32

Sclerotic changes of the manubrium sterni  

Energy Technology Data Exchange (ETDEWEB)

Six females with nearly identical sclerotic and hyperostotic changes of the manubrium sterni are reported. Malignancies, bacterial inflammatory processes, and Paget disease, which were first suspected, could be excluded. The youngest patients also had sclerotic changes of other bones, including the lumbar spine, the pubic bone, and the clavicle, and may be classified as having ''chronic recurrent multifocal osteomyelitis'' (CRMO). The two oldest patients had ossification of the costoclavicular ligament(s) and may be classified as having ''inter-sterno-costo-clavicular ossification'' (ISCCO). One had only hyperostotic and sclerotic changes as seen in ''sterno-costo-clavicular hyperostosis'' (SCCH). The pathogenesis of these uncommon diseases is unknown, but they are all frequently associated with pustulosis palmoplantaris and have similar clinical courses and laboratory abnormalities. None of the present patients had HLA-B/sub 27/. The similarity of the radiological abnormalities of the manubrium sterni suggests that the diseases themselves may be similar, but with different courses depending on age, CRMO being present in children and young adults and ISCCO or SCCH in older adults.

Jurik, A.G.; Graudal, H.; De Carvalho, A.

1985-03-01

33

Sclerotic cemental masses of the jaws (so-called chronic sclerosing osteomyelitis, sclerosing osteitis, multiple enostosis, and gigantiform cementoma.  

UK PubMed Central (United Kingdom)

A series of thirty-eight cases of densely sclerotic lesions of the jaws was studied. The lesions were all at least 1.5 cm, in diameter. Pain, drainage, or localized expansion of the jaw was present in two thirds of the patients. Thirty-four of the thirty-eight patients were women, and twenty-five were negros. In fourteen instances, a radiographic survey of the entire jaws was available. Thirteen of these fourteen patients had multiple lesions which were usually symmetrically distributed throughout the jaws. In twenty-four patients radiographs of the lesional area only were available for review. In thirty-four of the thirty-eight cases (89 per cent), the sclerotic masses were interpreted as cementum. Although this condition has previously been described as chronic sclerosing osteomyelitis, sclerosing osteitis, multiple enostosis, or gigantiform cementoma, it appears more appropriate to consider these lesions as part of the spectrum of the benign fibro-osseous lesions of periodontal ligament origin. Four of the sclerotic lesions, which were radiographically indistinguishable from the cemental lesions, consisted only of bone. Two of these appeared to be examples of true chronic sclerosing osteomyelitis, and two may be appropriately designated as enostosis or osteomas.

Waldron CA; Giansanti JS; Browand BC

1975-04-01

34

Surgical Management of Myxoma Like Sclerotic Calcified Mass in Left Ventricle Outflow Tract  

Directory of Open Access Journals (Sweden)

Full Text Available In this short report, we present the succesfull surgical traetment of a patient who had an echocardiographic diagnosis of left ventricular mass during her routine controls. This patient was treated by surgical excision of the ventricular mass and after the pathological examination the diagnosis was “myxoma like sclerotic calcified mass”. The postoperative course was uneventful, and the patient was discharged on day 7 of surgery. The follow-up period lasted for 2 years without any event and the echocardiograms revelaed no residual or reccurrent lesions. Surgical resection of intracardiac masses are necessary and safe treatment options but there is not a standardization about the type of surgical options. The localization of the mass has the key role in determining the type of the surgical approach. In this case, aortotomy provided a good access and facilitated the exposure of this rare myxoma like sclerotic calcified mass.

Atilla Sezgin; Hakk? Tankut Akay; Oktay Korun; Bahad?r Gültekin; Banu Bilezikçi

2011-01-01

35

Automated detection of sclerotic metastases in the thoracolumbar spine at CT.  

UK PubMed Central (United Kingdom)

PURPOSE: To design and validate a computer system for automated detection and quantitative characterization of sclerotic metastases of the thoracolumbar spine on computed tomography (CT) images. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board and was HIPAA compliant; informed consent was waived. The data set consisted of CT examinations in 49 patients (14 female, 35 male patients; mean age, 57.0 years; range, 12-77 years), demonstrating a total of 532 sclerotic lesions of the spine of greater than 0.3 cm(3) in volume, and in 10 control case patients (four women, six men; mean age, 55.2 years; range, 19-70 years) without spinal lesions. CT examinations were divided into training and test sets, and images were analyzed according to prototypical fully-automated computer-aided detection (CAD) software. Free-response receiver operating characteristic analysis was performed. RESULTS: Lesion detection sensitivity on images in the training set was 90%, relative to reference-standard marked lesions (95% confidence interval [CI]: 83%, 97%), at a false-positive rate (FPR) of 10.8 per patient (95% CI: 6.6, 15.0). For images in the testing set, sensitivity was 79% (95% CI: 74%, 84%), with an FPR of 10.9 per patient (95% CI: 8.5, 13.3). False-negative findings were most commonly (37 [40%] of 93) a result of endplate proximity, with 32 (34% of 93) caused by low CT attenuation. Marginal sclerosis caused by degenerative change (174 [28.1%] of 620 actual detections) was the most common cause of false-positive detections, followed by partial volume averaging with vertebral endplates (173 [27.9%] of 620) and pedicle cortex parallel to the axial imaging plane (121 [19.5%] 620). CONCLUSION: This CAD system successfully identified and segmented sclerotic lesions in the thoracolumbar spine.

Burns JE; Yao J; Wiese TS; Muñoz HE; Jones EC; Summers RM

2013-07-01

36

The bony labyrinth of Neanderthals.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This paper presents a comprehensive comparative analysis of the Neanderthal bony labyrinth, a structure located inside the petrous temporal bone. Fifteen Neanderthal specimens are compared with a Holocene human sample, as well as with a small number of European Middle Pleistocene hominins, and early...

Spoor, F; Hublin, JJ; Braun, M; Zonneveld, F

37

Multiple osteosclerotic lesions in an Iron Age skull from Switzerland (320-250 BC)--an unusual case.  

UK PubMed Central (United Kingdom)

The single Hochdorf burial was found in 1887 during construction work in the Canton of Lucerne, Switzerland. It dates from between 320 and 250 BC. The calvarium, the left half of the pelvis and the left femur were preserved. The finding shows an unusual bony alteration of the skull. The aim of this study was to obtain a differential diagnosis and to examine the skull using various methods. Sex and age were determined anthropologically. Radiological examinations were performed with plain X-ray imaging and a multislice computed tomography (CT) scanner. For histological analysis, samples of the lesion were taken. The pathological processing included staining after fixation, decalcification, and paraffin embedding. Hard-cut sections were also prepared. The individual was female. The age at death was between 30 and 50 years. There is an intensely calcified bone proliferation at the right side of the os frontalis. Plain X-ray and CT imaging showed a large sclerotic lesion in the area of the right temple with a partly bulging appearance. The inner boundary of the lesion shows multi-edged irregularities. There is a diffuse thickening of the right side. In the left skull vault, there is a mix of sclerotic areas and areas which appear to be normal with a clear differentiation between tabula interna, diploë and tabula externa. Histology showed mature organised bone tissue. Radiological and histological findings favour a benign condition. Differential diagnoses comprise osteomas which may occur, for example, in the setting of hereditary adenomatous polyposis coli related to Gardner syndrome.

Moghaddam N; Langer R; Ross S; Nielsen E; Lösch S

2013-01-01

38

Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis  

Directory of Open Access Journals (Sweden)

Full Text Available Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Quinck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones.A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, diagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

V Silva; H Madrid; S Anticevic

2007-01-01

39

Osteosclerotic lesions in patients treated with gefitinib for lung adenocarcinomas: a sign of favorable therapeutic response  

Energy Technology Data Exchange (ETDEWEB)

To assess the frequency of osteosclerotic changes on CT that appeared after treatment with gefitinib in patients with lung adenocarcinoma and the relationship between the osteosclerotic changes and the response to the therapy. Our study included 41 patients with lung adenocarcinoma who underwent chest CT both before (CTpre) and after (CTpost) starting treatment with gefitinib. The presence or absence of bone metastases was assessed on the CTpre, and the interval bony change after the therapy was classified as lytic, sclerotic, or no changes on the CTpost. The relationship between treatment results of primary lung cancer and interval bony changes was evaluated. Osteosclerotic lesions were identified in 11 patients (27%) on CTpost; in 6 of 11 patients osteosclerotic lesions newly appeared where the CTpre showed no bone metastasis before the gefitinib therapy. There were significant differences in the therapeutic response of the primary cancers (P < 0.001) and in the survival rate (P < 0.01) in patients with osteosclerotic changes versus those without osteosclerotic changes. Osteosclerotic changes on CT, observed after gefitinib treatment in patients with lung adenocarcinomas, may be an indicator of a good therapeutic response. (orig.)

Yamashita, Yoshiko; Aoki, Takatoshi; Korogi, Yukunori [University of Occupational and Environmental Health, School of Medicine, Department of Radiology, Kitakyushu (Japan); Hanagiri, Takeshi; Uramoto, Hidetaka [University of Occupational and Environmental Health, School of Medicine, Second Department of Surgery, Kitakyushu (Japan); Yoshii, Chiharu; Mukae, Hiroshi [University of Occupational and Environmental Health, School of Medicine, Department of Respiratory Disease, Kitakyushu (Japan)

2012-04-15

40

Bony ankylosis following thermal and electrical injury  

Energy Technology Data Exchange (ETDEWEB)

Objective. Bony ankylosis has been described following trauma, paralysis, psoriasis, Reiter's syndrome, ankylosing spondylitis, juvenile chronic arthritis and rheumatoid arthritis. Reports of bony ankylosis following thermal and electrical injury are limited.Design and patients. Thirteen cases of burn-related joint ankylosis in four patients are presented.Conclusion. Patients with burns from thermal or electrical injury may develop bony ankylosis among other radiographic manifestations. This bony ankylosis may result either from bridging extra-articular heterotopic ossification with preservation of the underlying joint or from intra-articular fusion due to joint destruction. (orig.)

Balen, P.F.; Helms, C.A. [Dept. of Radiology, Duke University Medical Center, Durham, NC (United States)

2001-07-01

 
 
 
 
41

Dopamine-Mediated Sclerotization of Regenerated Chitin in Ionic Liquid  

Directory of Open Access Journals (Sweden)

Full Text Available Chitin is a promising structural material for biomedical applications, due to its many advantageous properties and abundance in nature. However, its usage and development in the biomedical field have been stagnant, because of chitin’s poor mechanical properties in wet conditions and the difficulties in transforming it into an applicable form. To overcome these challenges, we created a novel biomimetic chitin composite. This regenerated chitin, prepared with ionic liquid, showed improved mechanical properties in wet conditions by mimicking insect cuticle and squid beak sclerotization, i.e., catechol-meditated cross-linking. By ionic liquid-based heat treatment, dopamine oxidation produced melanin-like compounds and dopamine-meditated cross-links without any solvent evaporation and oxidant utilization. The dopamine-meditated sclerotization increased the ultimate tensile strength (UTS) of the regenerated chitin by 2.52-fold, measured after six weeks of phosphate-buffered saline (PBS) submersion. In addition, the linear swelling ratio (LSR) of the chitin film was reduced by about 22%. This strategy raises a possibility of using regenerated chitin as an artificial hard tissue in wet conditions.

Dongyeop X. Oh; Sara Shin; Chanoong Lim; Dong Soo Hwang

2013-01-01

42

The long-term changes of hard palatal bony cleft defects after palatoplasty in unilateral complete cleft lip and palate.  

Science.gov (United States)

There have been few long-term studies regarding the change of bony cleft defects in cleft lip and palate after palatoplasty. The purpose of this study was to evaluate the regenerated bone formed in bony cleft defects and the change in bony cleft width after palatoplasty using computed tomography (CT). Thirty non-syndromic unilateral complete cleft lip and palate patients were retrospectively reviewed. The patients underwent palatoplasty at an average age of 14.32 months. CT was performed at an average age of 9.8 years. The authors evaluated the regenerated bone volume ratio, remnant bony cleft area ratio and change in bony cleft width at the posterior nasal spine. The relative locations of the regenerated bone lesion and the bony cleft to the hard palate were measured. Regenerated bone was observed in all patients. The average regenerated bone volume ratio was 61.1%, and the largest regenerated bone was usually located in the anterior half of the hard palate. The average remnant bony cleft area ratio was 7.6%, and the widest bony cleft was usually located in the anterior 1/3 and the posterior 1/3. The remnant bony cleft and non-regenerated bone lesion were rarely located in the middle 1/3. The bony cleft width at the posterior nasal spine decreased significantly after palatoplasty. Hard palatal bony cleft defects after palatoplasty were decreased by regenerated bone, and possibly by the contracting force of the scar at the midline of the hard palate, and the continuous pressure of the surrounding tissues. PMID:22817881

Choi, Jaehoon; Kwon, Geun-Yong; Kim, Sukwha; Choi, Tae Hyun

2012-07-19

43

The long-term changes of hard palatal bony cleft defects after palatoplasty in unilateral complete cleft lip and palate.  

UK PubMed Central (United Kingdom)

There have been few long-term studies regarding the change of bony cleft defects in cleft lip and palate after palatoplasty. The purpose of this study was to evaluate the regenerated bone formed in bony cleft defects and the change in bony cleft width after palatoplasty using computed tomography (CT). Thirty non-syndromic unilateral complete cleft lip and palate patients were retrospectively reviewed. The patients underwent palatoplasty at an average age of 14.32 months. CT was performed at an average age of 9.8 years. The authors evaluated the regenerated bone volume ratio, remnant bony cleft area ratio and change in bony cleft width at the posterior nasal spine. The relative locations of the regenerated bone lesion and the bony cleft to the hard palate were measured. Regenerated bone was observed in all patients. The average regenerated bone volume ratio was 61.1%, and the largest regenerated bone was usually located in the anterior half of the hard palate. The average remnant bony cleft area ratio was 7.6%, and the widest bony cleft was usually located in the anterior 1/3 and the posterior 1/3. The remnant bony cleft and non-regenerated bone lesion were rarely located in the middle 1/3. The bony cleft width at the posterior nasal spine decreased significantly after palatoplasty. Hard palatal bony cleft defects after palatoplasty were decreased by regenerated bone, and possibly by the contracting force of the scar at the midline of the hard palate, and the continuous pressure of the surrounding tissues.

Choi J; Kwon GY; Kim S; Choi TH

2012-11-01

44

Micromorphological and hardness analyses of human and bovine sclerotic dentin: a comparative study  

Directory of Open Access Journals (Sweden)

Full Text Available The purpose of this study was to test the hypothesis that both human and bovine sclerotic dentin have similar hardness properties, in addition to similar micromorphological characteristics. Sixteen teeth (8 human and 8 bovine) exhibiting exposed dentin in the incisal edge and showing characteristics typical of sclerosis were used. Vickers surface microhardness testing was conducted. Three areas of the dentin surface of each specimen were selected. All teeth were processed for scanning electron microscopy in order to estimate the amount (in percentage) of solid dentin on the sclerotic dentin surface. The data were compared by Student's t test (? = 0.05). The micromorphological and microhardness data were compared by Pearson's linear correlation test (? = 0.05). The mean percentages of solid dentin of human and bovine sclerotic dentin were similar (human 90.71 ± 0.83 and bovine 89.08 ± 0.81, p = 0.18). The mean microhardness value (VHN) of human sclerotic dentin was significantly higher than that of bovine sclerotic dentin (human 45.26 ± 2.92 and bovine 29.93 ± 3.83, p = 0.006). No correlation was found between the microhardness values and the amount of solid dentin in the sclerotic dentin, irrespective of the species considered (human R² = 0.0240, p = 0.714; bovine R² = 0.0017, p = 0.923; and combined R² = 0.038, p = 0.46). We concluded that although both bovine and human sclerotic dentin present a similar amount of solid tissue, human sclerotic dentin presents higher microhardness than bovine sclerotic dentin.

Gisela Muassab Castanho; Márcia Martins Marques; Juliana Barbosa Marques; Maitê André Camargo; Antonio Alberto De Cara

2011-01-01

45

An unusual image of the temporal bone due to a venous emissary in a sclerotic mastoid.  

UK PubMed Central (United Kingdom)

An unusual image of the temporal bone that is reminiscent of the thumb phalanges is described. This picture is due to an emissary vein in a bilaterally sclerotic mastoid with lateralization of the sigmoid sinus.

Di Segni R; Mazzamurro G; Cascino A; Di Lella V

1980-01-01

46

Factors affecting bony impingement in hip arthroplasty.  

UK PubMed Central (United Kingdom)

Computer modeling of 10 patients' computed tomographic scans was used to study the variables affecting hip arthroplasty range of motion before bony impingement (ROMBI) including acetabular offset and height, femoral offset, height and anteversion, and osteophyte removal. The ROMBI was compared with the ROM before component impingement and the native hip ROM. The ROMBI decreased with decreased total offset and limb shortening. Acetabular offset and height had a greater effect on ROMBI than femoral offset and height. The ROMBI lost with decreased acetabular offset was not fully recoverable with an increase in femoral offset or osteophyte removal. Bony impingement increased and component impingement decreased with decreased acetabular offset and increased head diameter.

Kurtz WB; Ecker TM; Reichmann WM; Murphy SB

2010-06-01

47

Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea/ Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Quinck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente (more) no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones. Abstract in english A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, diagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

Silva, V; Madrid, H; Anticevic, S

2007-01-01

48

Bony island within the articular cartilage of the knee in a child: a rare condition for early osteoarthritis  

Directory of Open Access Journals (Sweden)

Full Text Available Articular cartilage is a specific type of connective tissue composed of hydrated proteoglycans within a matrix of collagen fibrils. In the elderly population, it shows degenerative changes that may results in osteoarthritis. The more severe form of osteoarthritis occasionally demonstrates bone formation within the cartilage, which is designated as a bony protuberance, however, such lesions are rare in children. This report presents the case of a 10-year-old boy with a bony protuberance within the articular cartilage of the knee. The patient initially complained of knee pain and he subsequently developed flexion contracture. Radiological and arthroscopic examinations revealed a bony protuberance in the articular cartilage and degenerative changes of the cartilage above it. He was successfully treated by the removal of the bony protuberance and osteochondral grafting. The bony protuberance may have caused cartilage degradation since the thickness of the cartilage above it was thinner than that around the lesion. The bony protuberance within the articular cartilage formed in the younger population may be a possible cause of osteoarthritis. This case is a noteworthy with regard to the pathogenesis of osteoarthritis.

Taku Hatta; Takehiko Sugita; Toshimi Aizawa; Masahiro Ohnuma; Atsushi Takahashi; Eiji Itoi

2011-01-01

49

Sclerotic Vertebral Metastases: Pain Palliation Using Percutaneous Image-Guided Cryoablation  

International Nuclear Information System (INIS)

Cryoablative therapies have been proposed to palliate pain from soft-tissue or osteolytic bone tumors. A case of a patient with painful thoracic and sacral spine sclerotic metastases successfully treated by image-guided percutaneous cryoablation with the aid of insulation techniques and thermosensors is reported in this case report.

2011-01-01

50

Quantification of sclerotic renal glomeruli during the aging process in humans  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction. The aim of our research was to quantify the presence of totally sclerotized glomeruli during the aging process. Material and Methods. The study material were kidney tissue samples taken from fiftysix cadavers, their age ranging from 20 to over 70 years. They were classified in six age groups: I (20-29), II (30-39), III (40-49); IV (50-59); V (60-69) and VI (older than 70). The tissue samples were routinely histologically processed and then cut into the slices 5 mm thick, which were then stained and stereologically analyzed under the microscope with a projection screen (Reichert Visopan) with 10 x lens magnification and multipurpose test system M42 application. The analysis was carried out on 20 fields of vision per one sample. The numerical density of completely sclerotic and other glomeruli was measured, and the resulting percentages were obtained from this parameter. Results. Completely sclerotic glomeruli were not found in the first group. They were observed in the II aging group (5%) for the first time. Their numerical density and percentage increased during the aging process and was 18% in the IV, 25% in the V and maximally 37.5% in the VI aging group. Conclusion. Finally, the above cited results pointed to the increase of completely sclerotized and the decreased presence of normal glomeruli during the aging process

Stojanovi? Vesna; Jovanovi? Ivan; Ugrenovi? Sla?ana; Pavlovi? Snežana

2010-01-01

51

Generalized osteoblastic bony metastases from medulloblastoma.  

UK PubMed Central (United Kingdom)

Osteoblastic bony metastases were observed in a case of medulloblastoma three years after surgery and radiation treatment. There was clinical response to COP therapy (cytoxin, oncovin, prednisone). Radiographic and isotopic bone scan study showed uniform increase in bone density. Serum calcium and phosphorous and acid phosphatase levels were normal. Alkaline phosphatase was elevated and declined with therapy without change in the bone appearance. This suggested an increase in bone deposition activity. However, no increase in calcitonin level was detected either during active disease or following a chemotherapy-induced remission.

Ho EP; Lieber A; DeLand FH; Maruyama Y

1976-01-01

52

Incidental bony pathology when reporting trauma orthopantomograms  

Energy Technology Data Exchange (ETDEWEB)

Radiologists frequently report orthopantomograms (OPTs) and other views of the mandible, most often in patients who have suffered facial trauma. These examinations may reveal incidental pathology. It is important that radiologists are aware of the radiological appearances and the clinical significance of these lesions. In this review we will present examples of the more common odontogenic lesions including: radicular cyst, odontogenic keratocyst, dentigerous cyst, ameloblastoma, and also examples of non-odontogenic pathology: bisphosphonate-related osteonecrosis of the jaw (BRONJ) and chronic osteomyelitis. Although some of the lesions will require computed tomography (CT) or magnetic resonance imaging (MRI) for further lesion characterization and evaluation of the surrounding tissues, we are going to focus on the plain film appearances. We will also briefly discuss the pathogenesis, epidemiology, and treatment of these lesions.

Macanovic, M., E-mail: mladenmaca@gmail.co [Derriford Hospital NHS Trust, Plymouth (United Kingdom); Gangidi, S.; Porter, G.; Brown, S.; Courtney, D. [Derriford Hospital NHS Trust, Plymouth (United Kingdom); Porter, J. [Community Dental Service, Plymouth Primary Care Trust, Plymouth, Devon (United Kingdom)

2010-10-15

53

Incidental bony pathology when reporting trauma orthopantomograms  

International Nuclear Information System (INIS)

Radiologists frequently report orthopantomograms (OPTs) and other views of the mandible, most often in patients who have suffered facial trauma. These examinations may reveal incidental pathology. It is important that radiologists are aware of the radiological appearances and the clinical significance of these lesions. In this review we will present examples of the more common odontogenic lesions including: radicular cyst, odontogenic keratocyst, dentigerous cyst, ameloblastoma, and also examples of non-odontogenic pathology: bisphosphonate-related osteonecrosis of the jaw (BRONJ) and chronic osteomyelitis. Although some of the lesions will require computed tomography (CT) or magnetic resonance imaging (MRI) for further lesion characterization and evaluation of the surrounding tissues, we are going to focus on the plain film appearances. We will also briefly discuss the pathogenesis, epidemiology, and treatment of these lesions.

2010-01-01

54

Craniofacial fibroosseous lesions  

Directory of Open Access Journals (Sweden)

Full Text Available Fibroosseous lesions of the cranial and facial bones are usually benign and tend to grow slowly, yet act aggressively clinically. If not totally excised, recurrence is common in these locally destructive and deforming lesions. Degeneration into sarcoma has been reported in recurred lesions, as well. Diagnosis, classification and treatment of these lesions have exposed various difficulties in the past. Predilection sites are maxillae and mandibles. They are often seen in children and young adults.In this study 43 cases from Ege University Medical School Surgical Pathology Department between 1976 and 2004, and 12 cases from Uludag University Medical School Surgical Pathology Department between 2003 and 2006 were reviewed. Cases were noted as for age, gender, lesion site, lesion type, histological properties, recurrence, and degeneration into sarcoma.In conclusion we suggest that specific diagnosis of fibroosseous lesions of cranial and facial bony regions should rely on clinicopathological correlation and radiological findings along with pathological criteria.

Ulviye YALÇINKAYA; Ba?ak DO?ANAV?ARG?L; Murat SEZAK; Fikri ÖZTOP

2006-01-01

55

MRI of orbital lesions  

International Nuclear Information System (INIS)

MRI is a very sensitive method for detecting lesions of the orbit and the surrounding structures. Ultrasound and CT are very helpful tools in primary diagnosis of various diseases; CT, in particular, is better than MRI in identification bony erosions or destruction and in confirming calcification. MRI was performed on 138 patients with different lesions of the orbit (table 1). 21 patients suffered from ocular lesions, 24 patients from lesions of the optic nerve or the sheath and 93 patients from intra- or extraconal lesions. Certain lesions show characteristic signal intensities on T1- and T2-weighted images. The contrast medium Gd-DTPA is indicated in many cases, yielding more accurate diagnosis and higher specifity. (orig.).

1993-01-01

56

Direct bony invasion of malignant melanoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Malignant melanoma is known to spread by local extention, by the lymphatics by the blood stream. Direct invasion of the bone from a cutaneous melanoma is unknown. Hence, this case is presented in view of its rarity. A 75-year-old Caucasian lady presented with a small papillary lesion in the region o...

Mula Viswanath; Mandal Adhip; Britton Edward; Shanker Vaidyanathan

57

Laccase2 is required for sclerotization and pigmentation of Aedes albopictus eggshell.  

Science.gov (United States)

Laccase (EC 1.10.3.2) is a member of multicopper oxidases that have been found in higher plants, fungus, bacterium, and insects. Two types of laccase genes have been detected in many species of insects: laccase1 and laccase2. It has been identified that laccase2 enzyme may play a key role in sclerotization and pigmentation of insect cuticle. But few attentions were given to the biological role of laccase2 in the synthesizing of similar structures, such as oothecae, eggshell, or silk cocoons. We cloned laccase2 gene from Aedes albopictus, one main mosquito vector of dengue virus in China. An upregulation of laccase2 gene was observed after a blood meal in female adult mosquitoes, suggesting that laccase2 gene may have an involvement in the development of ovary. RNA interference experiment was performed by using adult female mosquitoes. Female mosquitoes were injected with 20 ng of double-strain RNA into the thorax. Pigmentation of mosquito eggshell was blocked that these eggs never became dark. And the incomplete sclerotization of eggshell weakened the stability and flexibility of the eggs. These eggs without enough protection were deformed and died in water. These results demonstrate that laccase2 plays a critical role in the development of eggs of A. albopictus. Laccase2 may provide a novel target for mosquito control and management. PMID:23455937

Wu, Xiansheng; Zhan, Ximei; Gan, Ming; Zhang, Dongjing; Zhang, Meichun; Zheng, Xiaoying; Wu, Yu; Li, Zhuoya; He, Ai

2013-03-01

58

Laccase2 is required for sclerotization and pigmentation of Aedes albopictus eggshell.  

UK PubMed Central (United Kingdom)

Laccase (EC 1.10.3.2) is a member of multicopper oxidases that have been found in higher plants, fungus, bacterium, and insects. Two types of laccase genes have been detected in many species of insects: laccase1 and laccase2. It has been identified that laccase2 enzyme may play a key role in sclerotization and pigmentation of insect cuticle. But few attentions were given to the biological role of laccase2 in the synthesizing of similar structures, such as oothecae, eggshell, or silk cocoons. We cloned laccase2 gene from Aedes albopictus, one main mosquito vector of dengue virus in China. An upregulation of laccase2 gene was observed after a blood meal in female adult mosquitoes, suggesting that laccase2 gene may have an involvement in the development of ovary. RNA interference experiment was performed by using adult female mosquitoes. Female mosquitoes were injected with 20 ng of double-strain RNA into the thorax. Pigmentation of mosquito eggshell was blocked that these eggs never became dark. And the incomplete sclerotization of eggshell weakened the stability and flexibility of the eggs. These eggs without enough protection were deformed and died in water. These results demonstrate that laccase2 plays a critical role in the development of eggs of A. albopictus. Laccase2 may provide a novel target for mosquito control and management.

Wu X; Zhan X; Gan M; Zhang D; Zhang M; Zheng X; Wu Y; Li Z; He A

2013-05-01

59

Accumulation of cholesterol in the lesions of focal segmental glomerulosclerosis.  

UK PubMed Central (United Kingdom)

Intraglomerular deposition of low-density lipoprotein (LDL) and oxidized LDL has been described in various human glomerular diseases. Yet it is not clear whether esterified cholesterol (EC) and unesterified cholesterol (UC) carried in LDL are mobilized from deposited LDL particles or accumulate in the diseased human glomeruli, particularly in the segmentally sclerotic lesions. To address this issue, frozen sections of renal biopsies were first immunostained to localize apolipoprotein B (apo B) and then oil red O (ORO) stained to colocalize neutral lipids. By using 124 ORO-positive biopsies and nine ORO-negative ones, UC was visualized directly with filipin staining, and EC was visualized after its enzymatic hydrolysis and staining with filipin. Seventy-seven biopsies (58%) showed filipin staining of accumulated EC and/or UC in the glomeruli. Of these, 11 showed heavy filipin staining for both EC and UC in the segmentally sclerotic lesions. In a group with UC deposits in the sclerotic segments, the percentage of the glomeruli affected by sclerosis and the intensity of filipin fluorescence for UC were significantly higher than biopsies with only mesangial UC deposits. Most filipin-positive biopsies showed apo B staining mainly in the mesangium. Yet in the sclerotic segments, apo B staining was rarely noted. Accumulated apo B-stained lipoprotein was not coincident with ORO-stained lipid in the diseased glomeruli. These results suggest that both EC and UC accumulate in the sclerotic glomerular segments as the glomerular lesions are advanced, and that these EC and UC appear to be derived from altered LDL with progressive loss of apo B.

Lee HS; Kruth HS

2003-10-01

60

Bony landmarks as an aid for intraoperative facial nerve identification  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Identification of the facial nerve trunk is essential during surgery of the parotid gland. Numerous landmarks have been researched and used. The relation between the facial nerve to two constant bony landmarks, the tip of the mastoid process and the central point of the transverse process of the atl...

Greyling, Linda M.; Glanvill, R.; Boon, J.M.; Schabort, D.; Meiring, J.H.; Pretorius, Jan P.; Van Schoor, Albert-Neels

 
 
 
 
61

Bony exostosis of the atlas with resultant cranial nerve palsy  

Energy Technology Data Exchange (ETDEWEB)

A case of tenth and twelfth nerve compression secondary to a bony exostosis of the first cervical vertebra is described. This uncommon phenomenon serves to outline the importance of imaging the course of a cranial nerve when no intracranial abnormality is demonstrable on CT or MRI. The radiologic features of spinal osteochondromas are reviewed. (orig.).

Slavotinek, J.P.; Sage, M.R. (Flinders Medical Centre, Bedford Park (Australia). Dept. of Radiology); Brophy, B.P. (Flinders Medical Centre, Bedford Park (Australia). Dept. of Neurosurgery)

1991-10-01

62

Rosai-Dorfman Disease: Report of a Case Associated with IgG4-Related Sclerotic Lesions.  

UK PubMed Central (United Kingdom)

We describe a rare case of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) associated with a six-year history of autoimmune pancreatitis, which was controlled by steroid treatment. The patient presented with multiple, cervical and thoracic lymphadenopathy and abnormal, nodular opacities in the lung. Histologically, Rosai-Dorfman disease with numerous IgG4-positive cells was identified in a subcutaneous lymph node in the patient's left forearm. The patient recovered uneventfully with steroid treatment.

Park BH; Son da H; Kim MH; Shim TS; Lee HJ; Huh J

2012-12-01

63

Rosai-Dorfman Disease: Report of a Case Associated with IgG4-Related Sclerotic Lesions.  

Science.gov (United States)

We describe a rare case of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) associated with a six-year history of autoimmune pancreatitis, which was controlled by steroid treatment. The patient presented with multiple, cervical and thoracic lymphadenopathy and abnormal, nodular opacities in the lung. Histologically, Rosai-Dorfman disease with numerous IgG4-positive cells was identified in a subcutaneous lymph node in the patient's left forearm. The patient recovered uneventfully with steroid treatment. PMID:23323110

Park, Bong-Hee; Son, Da Hye; Kim, Myung-Hwan; Shim, Tae Sun; Lee, Hee Jin; Huh, Jooryung

2012-12-26

64

[Thirst and extensive bone lesions in a previously basically healthy woman].  

Science.gov (United States)

A previously quite healthy 65-year-old woman sought emergency hospital care due to fatigue, weight loss and sensation of thirst appearing over a couple of months. Further analysis revealed a process affecting the neurohypophysis and extensive lytic sclerotic bone lesions. Eventually a rare generalized underlying disease was unraveled: the diagnosis included both Langerhans cell histiocytosis and Erdheim-Chester disease. PMID:23342482

Laitinen, Kalevi; Lamminen, Antti; Anttila, Pekka; Lohman, Martina; Karjalainen-Lindsberg, Marja-Liisa

2012-01-01

65

Clinicopathologic characteristics and mucin expression in Brunner's gland proliferating lesions.  

UK PubMed Central (United Kingdom)

BACKGROUND: Brunner's gland proliferating lesions, termed Brunner's gland hamartoma, hyperplasia, or adenoma, is regarded as a benign condition. However, cancerous changes have been reported in Brunner's gland proliferating lesions. AIMS: The purpose of this study was to define the characteristic features of Brunner's gland proliferating lesions and evaluate any observed cancerous changes. METHODS: We analysed clinicopathologic features and mucin expression in 25 Brunner's gland proliferating lesions. RESULTS: Brunner's gland proliferating lesions were categorized as Brunner's gland hamartoma or hyperplasia according to their tissue components. Brunner's gland hamartoma commonly occurred in the duodenal bulb and exhibited a polypoid appearance, while Brunner's gland hyperplasia was primarily observed in the second portion of duodenum as a submucosal mass and was accompanied by symptoms more frequently than Brunner's gland hamartoma. The Brunner's glands in Brunner's gland proliferating lesions exhibited various morphologic characteristics, from normal-appearing glands to sclerotic glandular foci with atypia. Changes in MUC5 expression observed in both sclerotic glandular foci and dilated Brunner's glands suggest that they might share a common mechanism and are associated with gastric foveolar metaplasia. CONCLUSIONS: These findings indicate that most Brunner's gland proliferating lesions are either hamartoma or hyperplasia, and that true neoplastic Brunner's gland proliferating lesions are very rare. Thus, Brunner's gland adenomas or carcinomas arising in Brunner's gland proliferating lesions should be confirmed by ancillary tests, including immunostaining or molecular analysis, in addition to morphological criteria.

Kim K; Jang SJ; Song HJ; Yu E

2013-01-01

66

Syringocystadenoma Papilliferum of the Bony External Auditory Canal: A Rare Tumor in a Rare Location  

Science.gov (United States)

Tumors originating from ceruminous glands are rare lesions of the external auditory canal. The lack of specific clinical and radiological signs makes their diagnosis challenging. We report the case of an exceptionally rare benign tumor, a syringocystadenoma papilliferum (SCAP), in an atypical location in the bony segment of the external auditory canal with uncommon clinical signs. The special traits of the case included the following: the most lateral component of the tumor was macroscopically cystic and a granular myringitis with an obstructing keratin mass plug was observed behind the mass. The clinical, audiological, radiological, and histological characteristics of the neoplasm are consequently presented. Intraoperative diagnosis of the epidermal cyst was proposed. The final diagnosis of SCAP was determined only by histological analysis after the surgical excision. The educational aspects of the case are critically discussed.

Balseris, Svajunas

2013-01-01

67

Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location.  

UK PubMed Central (United Kingdom)

Tumors originating from ceruminous glands are rare lesions of the external auditory canal. The lack of specific clinical and radiological signs makes their diagnosis challenging. We report the case of an exceptionally rare benign tumor, a syringocystadenoma papilliferum (SCAP), in an atypical location in the bony segment of the external auditory canal with uncommon clinical signs. The special traits of the case included the following: the most lateral component of the tumor was macroscopically cystic and a granular myringitis with an obstructing keratin mass plug was observed behind the mass. The clinical, audiological, radiological, and histological characteristics of the neoplasm are consequently presented. Intraoperative diagnosis of the epidermal cyst was proposed. The final diagnosis of SCAP was determined only by histological analysis after the surgical excision. The educational aspects of the case are critically discussed.

Arechvo A; Balseris S; Neverauskiene L; Arechvo I

2013-01-01

68

Association Between the Proportion of Sclerotic Glomeruli and Serum Creatinine in Primary Focal Segmental Glomerulosclerosis  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To evaluate the possible correlation between the extent of sclerotic glomeruli and the level of serum creatinine and its clearance rate in patients with primary focal segmental glomerolusclerosis.Material and Method: In a cross-sectional study, 50 patients with biopsy-proven primary focal segmental glomerolusclerosis were recruited. The proportion of globally and segmentally sclerosed glomeruli was determined during the first histopathological examination of renal biopsy specimens. Correlations of these variables with on admission serum level of creatinine and its clearance rate were investigated.Results: Twenty-four males and 26 females with a mean age of 39.82±16.45 (range: 16-85) years were enrolled in the study. In a significant fashion, the proportions of segmental and global glomerulosclerosis were directly correlated with the serum level of creatinine and inversely with its clearance rate (r=-0.43 with p=0.002 and r=-0.45 with p=0.001, respectively).Conclusion: Apart from the degree of interstitial fibrosis, the serum level of creatinine and its clearance rate are well correlated with the proportions of both segmentally and globally sclerosed glomeruli in primary focal segmental glomerulosclerosis.

Ashraf FAKHRJOU; Ahad HASHEMPOUR; Sepideh SHADRAVAN; Rohollah Fadaei FOULADI

2012-01-01

69

Bone density three-dimensional CT of skull base lesions. Simultaneous use of multiplanar reconstruction  

International Nuclear Information System (INIS)

[en] We performed bone density three-dimensional CT (3D-CT) of six skull base lesions. Multiplanar reconstruction (MPR) was also performed in 5 cases. The ability to demonstrate the lesions on 3D-CT was examined in addition to additional information of MPR. 3D-CT clearly demonstrated the bony lesions in 5 cases. In one case, the internal architecture of the lesion was visualized with cutting procedure. In all, minute bony change and adjacent soft tissue lesion were observed at any plane on MPR. Simultaneous use of 3D-CT and MPR may be useful for demonstrating skull base lesions. (author)

1998-01-01

70

Bone density three-dimensional CT of skull base lesions. Simultaneous use of multiplanar reconstruction  

Energy Technology Data Exchange (ETDEWEB)

We performed bone density three-dimensional CT (3D-CT) of six skull base lesions. Multiplanar reconstruction (MPR) was also performed in 5 cases. The ability to demonstrate the lesions on 3D-CT was examined in addition to additional information of MPR. 3D-CT clearly demonstrated the bony lesions in 5 cases. In one case, the internal architecture of the lesion was visualized with cutting procedure. In all, minute bony change and adjacent soft tissue lesion were observed at any plane on MPR. Simultaneous use of 3D-CT and MPR may be useful for demonstrating skull base lesions. (author)

Suzuki, Masayuki; Takashima, Tsutomu; Ueda, Fumiaki [Kanazawa Univ. (Japan). School of Medicine] [and others

1998-04-01

71

[Ultrastructure of granulocytes of bony fishes (orders Salmoniformes, Cypriniformes, Perciformes)].  

UK PubMed Central (United Kingdom)

Analysis of data on utrastructure of granulocytes of freshwater and marine bony fish of orders Salmoniformes, Cypriniformes, and Perciformes showed that in all studied species there were revealed two types of granulocytes - neutrophils and eosinophils. The exception was the bluefish Pomatomus saltatrix L. whose pronephros hemopoietic tissue was found to contain one type of the granulocytic line - neutrophils. The identification parameters of granular leukocytes are specific granules filling the cytoplasm. The main form of specific granules in neutrophils of bony fish of various phylogenetic groups is an elongated granule with different distribution of fibrils or a granule that has crystalloid formed from fibrils. The main form of eosinophil granules - large, electron-dense, homogenous.

Flerova EA; Balabanova LV

2013-03-01

72

La displasia cemento ósea florida y su diagnóstico diferencial/ The Florid cemento-bony dysplasia and the differential diagnosis  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Las lesiones benignas fibro-óseas de los maxilares constituyen un grupo diverso de enfermedades con una característica histológica común: la sustitución de hueso normal por tejido compuesto de colágeno y fibroblastos, con cantidades variables de una sustancia mineral que puede ser de hueso, cemento o ambos. Estas lesiones incluyen la displasia fibrosa, la displasia cemento-ósea en sus variantes: periapical, focal o florida, el cementoma gigantiforme familiar y el f (more) ibroma osificante cemento-osificante. La osteomielitis es un proceso inflamatorio agudo o crónico de los espacios medulares o corticales del hueso, que se extiende más allá del sitio inicial de desenvolvimiento. La osteomielitis esclerosante difusa es más frecuente en adultos, principalmente en la mandíbula. Se presenta radiográficamente como una lesión radiopaca difusa adyacente a los dientes, que puede ser multifocal. El objetivo de este trabajo fue describir un caso inusual de lesión fibro-ósea, cuyo diagnóstico diferencial se hizo también con la osteomielitis de los maxilares. Se concluyó que las lesiones fibro-óseas benignas, presentaron muchas similitudes con respecto a sus aspectos clínicos, radiográficos e histológicos. Por lo tanto, es fundamental el análisis conjunto de estas informaciones para obtener un diagnóstico definitivo. Abstract in english The benign fibrous-bony lesions are a diverse group of diseases with common features: replacement of normal bone by tissue composed of collagen and fibroblasts, with variable amounts of a mineral substance that could be bone, cement or both. These lesions include the fibrous dysplasia, the periapical cement-bony dysplasia, focal or florid, familiar giant cementoma and ossifying fibroma (cement-ossifying). Osteomyelitis is an acute or chronic inflammatory process of medull (more) ar or cortical spaces of bone extending beyond the onset site of development. Diffuse sclerosing osteomyelitis involves to adults mainly the mandible and radiographically is a diffuse radiopaque lesion adjacent to teeth and could be multifocal. The aim of present paper is to describe an uncommon case of fibrous-bony lesion also diagnosed with maxillary osteomyelitis. We conclude that the above mentioned lesions are very similar regarding its clinical, radiographic and histological features. Thus, it is fundamental the combined analysis of these informations to obtain a definite diagnosis.

Carvalho de Melo, Allan Ulisses; Ferreira Ribeiro, Cyntia; de Santana Santos, Thiago; Barreto Aguiar, Luciana; Azevedo Rocha, Betsabé; Almeida Júnior, Paulo; Cavalcanti Albuquerque Júnior, Ricardo Luiz

2011-09-01

73

La displasia cemento ósea florida y su diagnóstico diferencial The Florid cemento-bony dysplasia and the differential diagnosis  

Directory of Open Access Journals (Sweden)

Full Text Available Las lesiones benignas fibro-óseas de los maxilares constituyen un grupo diverso de enfermedades con una característica histológica común: la sustitución de hueso normal por tejido compuesto de colágeno y fibroblastos, con cantidades variables de una sustancia mineral que puede ser de hueso, cemento o ambos. Estas lesiones incluyen la displasia fibrosa, la displasia cemento-ósea en sus variantes: periapical, focal o florida, el cementoma gigantiforme familiar y el fibroma osificante cemento-osificante. La osteomielitis es un proceso inflamatorio agudo o crónico de los espacios medulares o corticales del hueso, que se extiende más allá del sitio inicial de desenvolvimiento. La osteomielitis esclerosante difusa es más frecuente en adultos, principalmente en la mandíbula. Se presenta radiográficamente como una lesión radiopaca difusa adyacente a los dientes, que puede ser multifocal. El objetivo de este trabajo fue describir un caso inusual de lesión fibro-ósea, cuyo diagnóstico diferencial se hizo también con la osteomielitis de los maxilares. Se concluyó que las lesiones fibro-óseas benignas, presentaron muchas similitudes con respecto a sus aspectos clínicos, radiográficos e histológicos. Por lo tanto, es fundamental el análisis conjunto de estas informaciones para obtener un diagnóstico definitivo.The benign fibrous-bony lesions are a diverse group of diseases with common features: replacement of normal bone by tissue composed of collagen and fibroblasts, with variable amounts of a mineral substance that could be bone, cement or both. These lesions include the fibrous dysplasia, the periapical cement-bony dysplasia, focal or florid, familiar giant cementoma and ossifying fibroma (cement-ossifying). Osteomyelitis is an acute or chronic inflammatory process of medullar or cortical spaces of bone extending beyond the onset site of development. Diffuse sclerosing osteomyelitis involves to adults mainly the mandible and radiographically is a diffuse radiopaque lesion adjacent to teeth and could be multifocal. The aim of present paper is to describe an uncommon case of fibrous-bony lesion also diagnosed with maxillary osteomyelitis. We conclude that the above mentioned lesions are very similar regarding its clinical, radiographic and histological features. Thus, it is fundamental the combined analysis of these informations to obtain a definite diagnosis.

Allan Ulisses Carvalho de Melo; Cyntia Ferreira Ribeiro; Thiago de Santana Santos; Luciana Barreto Aguiar; Betsabé Azevedo Rocha; Paulo Almeida Júnior; Ricardo Luiz Cavalcanti Albuquerque Júnior

2011-01-01

74

Zygoma implant reconstruction of acquired maxillary bony defects.  

UK PubMed Central (United Kingdom)

The reconstruction of acquired maxillary bony defects after pathologic ablation, infectious debridement, avulsive trauma, or previously failed reconstructions with zygoma implants represents a treatment alternative that is safe, predictable, and cost-effective. Still the single most important factor for treatment success of these complex reconstructions is the implementation of a team approach between the surgeon and the restorative dentist. The focus of this article is to review the surgical and prosthetic nuances to successfully reconstruct acquired maxillary defects with zygoma implants.

Vega LG; Gielincki W; Fernandes RP

2013-05-01

75

Variation in prostate position relative to adjacent bony anatomy  

International Nuclear Information System (INIS)

Purpose: In prostatic cancer, the prostate cannot be discerned from a portal image. Setup information is, therefore, obtained from bony anatomy. To perform high-precision conformal therapy, knowledge about the variation in distance between the prostate and adjacent bony anatomy during an external radiotherapy treatment is mandatory. This report is concerned with that variation. Methods and Materials: Nine patients previously treated interstitially for prostatic cancer with implantation of 125I seeds, agreed to cooperate in a study. They underwent a number of simulations of external radiotherapy treatment. After the first patient setup, this setup was repeated five times for each patient as if the patient was treated by external radiotherapy. Simulator radiographs were made from each setup in the anterior-posterior and left-right lateral directions. The seeds were clearly visible in the simulator film images and reflect the position of the prostate. No bladder instructions were given and the filling of the rectum was not quantified. Results: Variation in distance between the prostate and the bony anatomy was measured and is presented in one standard deviation of the normal distribution function: 0.8 mm lateral, 1.5 mm ventrodorsal, and 1.7 mm craniocaudal. Conclusion: The bone structure of the pelvis reflects fairly well the position of the prostate. The prostate is least mobile in a lateral direction and most mobile in the craniocaudal and ventrodorsal directions.

1996-02-01

76

[Bony ongrowth on the surface of HA-coated femoral implants: an x-ray analysis].  

UK PubMed Central (United Kingdom)

BACKGROUND: To facilitate implant osseointegration in the early postoperative period, coating of the implant surfaces with osseoconductive materials, e.g. hydroxyapatite (HA), is being increasingly recommended. It apparently reduces the rate of radiolucent lines and even improves the osseointegration of implants less well suited for cementless anchorage. We analysed HA-coated stems to find out whether newly formed bone adherent to the implant surface such as seen on explanted stems is also seen on radiographs and whether it follows a specific morphological pattern. We also wanted to know whether newly formed peri-implant bone extends over the entire length of the HA-coating, at which point in time it is seen radiographically and whether it expands within the first few years post implantation by radiological evidence. PATIENTS AND METHOD: Radiographs of 40 unselected patients after primary total hip arthroplasty (THR), 14 males and 26 females, aged 44.4 to 86.7 years at the time of THR, with a mean age of 67.3 years were available for analysis. Monitor-guided a.-p. and axial views of the stems were obtained in the early postoperative period up to 6 weeks post THR, at a mean follow-up time of 1.3 (1.0 to 1.8) years and 3.0 (1.9 to 3.7) years. Tapered straight stems with a rectangular cross-section made of a wrought Ti6AI7Nb alloy with an HA coating in the proximal third were used. RESULTS: A.-p. views: At one year there were no signs suggesting an increased ongrowth of bone. At 3 years, on average, delicate bony appositions were seen on the implant surfaces in position 1 in three stems, in one of them also in position 7. These looked like a sclerotic zone lacking a sharp demarcation and were in direct contact with the implants without any bone-to-implant gaps. Axial views: At about one year two stems showed delicate bony appositions parallel to the implant surface in the proximal part in positions 8 and 9 as well as 13 and 14. Named "miniscleroses" by us, these structures were confined to the length of the HA coating. At three years these miniscleroses were clearly visible around 11 stems (more than 25?%). Those already seen at one year were much better defined at three years, but still confined to the HA-coated part of the stem. Some of them were poorly demarcated from the adjacent bone and medullary canal and some showed smooth demarcations. The density of the bony ongrowths was either homogeneous or increased from the medullary space or adjacent bone towards the implant surface. All of them were adherent to the implant surface. While not related to the peri-implant cortical bone, they were in contact with trabecular structures. After a mean follow-up time of one year radiolucent lines were seen around four stems in positions 1, 7 and 8. These were up to 1?mm in size around two stems and 2?mm or more in the other two. At 3 years all of the visible radiolucencies had disappeared except for one measuring 1?mm in position 8. CONCLUSIONS: The structures we found radiographically apparently reflect newly formed bone along the entire HA-coated implant surface. Most of them were located in positions 8, 9 and 13, 14. They provide visible evidence of osseointegration at osseoconductive surfaces. As they apparently did not have any contact with the peri-implant bone, they appear to be compatible with the bilateral osteogenesis according to Osborn. The effects of the rapid bony ongrowth on HA-coated surfaces and the striking absence of radiolucencies on the long-term outcome are still speculative. But the structures seen may be taken as a sign of improved implant stability by rapid osseointegration and of early sealing of the medullary canal. As a result, wear particles of the articulating surfaces are barred from spreading to the medullary cavity of the femur. This alone argues in favour of using coated implants throughout. However, more studies are needed to shed light on these issues.

Zweymüller KA

2012-02-01

77

The diagnosis of sacral lesions.  

UK PubMed Central (United Kingdom)

Clinical courses are reviewed in 4 recent patients with sacral lesions, each of whom was believed on initial clinical evaluation to have symptomatic herniations of intervertebral discs. In each patient pain in the back tended to overshadow radicular symptoms, and sphincteric disturbances were not prominent. Each patient presented some related objective abnormality on general or neurologic examination. The sacral lesion was invariably visible on technically satisfactory plain roentgenograms of the spine and was obvious on sacral tomography. Conventional myelography was useful in defining communication between the lesion and the subarachnoid space, but otherwise typically it was only subtly and nonspecifically abnormal. Computerized tomography (CT) proved to be the most revealing radiographic technique, demonstrating bony detail as well as internal structure and extent of the lesion; in conjunction with metrizamide myelography, CT provided the most definitive anatomical study. The limited utility of angiography in diagnosing these lesions is discussed, as are the respective hazards of and indications for needle biopsy and open surgical exploration.

Luken MG 3rd; Michelsen WJ; Whelan MA; Andrews DL

1981-05-01

78

Abdominal aortic aneurysm with bony erosion mimicking recurrent non-Hodgkin lymphoma on FDG PET/CT.  

UK PubMed Central (United Kingdom)

An 80-year-old man with a history of non-Hodgkin lymphoma in complete remission after chemotherapy in 2009 presented with lumbar pain. MRI demonstrated anterior L4 bony erosions. FDG PET/CT revealed the large retroperitoneal mass with central photopenia and a mildly hypermetabolic rim. Ultrasound revealed a dilated aorta with atherosclerotic plaque and eccentric mural thrombus. A newly developed mass-like lesion in a patient with history of lymphoma could be mistaken for lymphoma recurrence on FDG PET/CT.

Kim DW; Kim WH; Kim CG

2013-05-01

79

Audiological signs in pediatric cases with dehiscence of the bony labyrinth caused by a high jugular bulb.  

UK PubMed Central (United Kingdom)

Clinical findings were assessed in three pediatric cases of dehiscence of the bony labyrinth caused by a high jugular bulb (HJB). Two children had two dehiscent lesions, which included posterior semicircular canal dehiscence (PSCD) and vestibular aqueduct dehiscence (VAD). One child had VAD alone. Two subjects with PSCD, but not with VAD alone, had mixed hearing loss and showed wave motion of the baseline on tympanometry and acoustic reflex testing, and a reduced response on otoacoustic emission. These findings may reflect jugular venous pulsations transmitted through the PSC and represent characteristics of cases with PSCD caused by HJB.

Sone M; Katayama N; Naganawa S; Yoshida T; Teranishi M; Nakashima T

2012-03-01

80

MR imaging of growth plate injury in rabbit: development of bony bridge and pathologic correlation  

Energy Technology Data Exchange (ETDEWEB)

To evaluate the MR findings of a development of bony bridge within tunnels drilled across growth plates after injury in immature rabbits, and to correlate the MR and pathological findings. In 19 young rabbits, a growth-plate injury model was constructed in the distal femur by longitudinal drilling with a 5-mm drill. Coronal scans with T1-weighted, T2-weighted fast spin-echo, gradient echo, and gadolinium enhanced T1-weighted sequences were obtained immediately, and at 1, 2, 3, and 4 weeks, and 3, 6 months, postoperatively. Each group underwent pathologic examination, and the signal intensity, shape, and enhancement pattern of the drill holes were assessed. All results were correlated with pathologic findings. During the early period, the signal intensity of the defect site varied due to hemorrhage and inflammatory reaction in the lesion, becoming isointense to that of metaphyseal marrow on all sequences during the late period (3 and 6 months). Pathologically, it corresponded to replacement of the osseous bridge with fatty marrow. The new bone formation shown by pathologic examination to be present in the periphery of the defect during the first week corresponded to the vertical dark rim seen on MR images. It appeared during that week and became more distinct, thickening gradually until the fourth week. Enhancement was absent or faint on follow-up immediately after surgery, inhomogeneous and seen in half the rabbits at week 1, and maximal and homogenous at weeks 2 and 3. It had decreased by week 4, and was absent at months 3 and 6. These findings corresponded to the changes in transphyseal vascularity across the drill hole revealed by pathologic examination. The contrast enhancement demonstrated by defective growth plate may indicate the development of vascularity throughout the plate, a phenomenon which precedes the formation of a bony bridge after trauma. (author)

Seong, Chang Kyu; Kim, In One; Cheon, Jung Eun; Kim, Woo Sun; Yeon, Kyung Mo [College of Medicine and the Institute of Radiation Medicine, Seoul National University, Seoul (Korea, Republic of); Seong, Chang Kyu [College of Medicine, Kyungpook National University, Taegu (Korea, Republic of); Kim, Hyung Jin [College of Medicine, Inha University, Inchon (Korea, Republic of)

2000-09-01

 
 
 
 
81

MR imaging of growth plate injury in rabbit: development of bony bridge and pathologic correlation  

International Nuclear Information System (INIS)

To evaluate the MR findings of a development of bony bridge within tunnels drilled across growth plates after injury in immature rabbits, and to correlate the MR and pathological findings. In 19 young rabbits, a growth-plate injury model was constructed in the distal femur by longitudinal drilling with a 5-mm drill. Coronal scans with T1-weighted, T2-weighted fast spin-echo, gradient echo, and gadolinium enhanced T1-weighted sequences were obtained immediately, and at 1, 2, 3, and 4 weeks, and 3, 6 months, postoperatively. Each group underwent pathologic examination, and the signal intensity, shape, and enhancement pattern of the drill holes were assessed. All results were correlated with pathologic findings. During the early period, the signal intensity of the defect site varied due to hemorrhage and inflammatory reaction in the lesion, becoming isointense to that of metaphyseal marrow on all sequences during the late period (3 and 6 months). Pathologically, it corresponded to replacement of the osseous bridge with fatty marrow. The new bone formation shown by pathologic examination to be present in the periphery of the defect during the first week corresponded to the vertical dark rim seen on MR images. It appeared during that week and became more distinct, thickening gradually until the fourth week. Enhancement was absent or faint on follow-up immediately after surgery, inhomogeneous and seen in half the rabbits at week 1, and maximal and homogenous at weeks 2 and 3. It had decreased by week 4, and was absent at months 3 and 6. These findings corresponded to the changes in transphyseal vascularity across the drill hole revealed by pathologic examination. The contrast enhancement demonstrated by defective growth plate may indicate the development of vascularity throughout the plate, a phenomenon which precedes the formation of a bony bridge after trauma. (author)

2000-01-01

82

Lifa Disease: Frictional Dermal Melanosis over Bony Prominences (Clinicopathological Study)  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Lifa disease (Frictional dermal melanosis over bony prominences) has been described in Iraq for the first time in 1993, as a new distinctive pigmentary skin condition that followed chronic friction with a body washing agent (lifa) during bathing. Objective: To assess this increasingly common problem where still many doctors unaware about its presence especially in other Middle East countries. Patients and Methods: A case series descriptive study done in Departments of Dermatology-Najaf and Baghdad Teaching Hospitals, between March 2007- Oct.2008. Full history and clinical examination were done for all patients including Wood's light examination. Biopsies were taken from 21 patients and sent for hematoxylin-eosin and Congo red stains. Results: Fifty two (49 female and 3 male) patients with typical clinical features of lifa disease were studied. The mean age of presentation was 27.92 ± 7.58 years. All patients were slim with prominent bones and low body mass index, used lifa vigorously during bathing.Pigmentation was distributed bilaterally and symmetrically over bony prominences. The most common affected sites were: clavicular areas (67.3%) and upper back (42%). Wood's light and histopathological examinations revealed dermal melanosis. No amyloid deposit was detected by using Congo red stain in any patient. Conclusions: Lifa disease is a common distinctive pigmentary disfiguring problem especially among females. The histopathology showed dermal melanosis, and might be confused with other pigmentary problems like macular amyloidosis.

Khalifa E. Sharquie; Muhsin A. Al-Dhalimi; Adil A. Noaimi; Hussein A. Al-Sultany

2012-01-01

83

CT of cholesteatomas - In respect to bony complications  

Energy Technology Data Exchange (ETDEWEB)

We retrospectively analyzed twenty-eight cases of surgically confirmed cholesteatoma with CT putting emphasis on the following items: (1) location and extent of cholesteatoma: (2) erosion of scutum and lateral attic wall; (3) erosion of ossicles; (4) erosion of the bony labyrinth; (5) erosion of the facial nerve canal (6) erosion of the tegmen; (7) erosion of the sigmoid sinus; (8) erosion of the bony external auditory canal; and (9) intracranial complications. CT correctly predicted extent of 16 cases among surgically well documented 23 cholesteatomas. It was difficult to differentiate cholesteatoma from granulation tissue. Erosion of the scutum and/or lateral attic wall was seen in 16 cases (57%). The diagnostic accuracy of CT in the evaluation of the status of the ossicles was 92% (22/24). The most commonly involved portion of the ossicles was the long process of incus. There were seven cases having erosion of the bony labyrinth. Lateral semicircular canal was exclusively eroded. Coronal CT depicted erosion of lateral semicircular canal more accurately. Facial nerve canal erosion was found in six cases (21%). Eroded portion was distal limb of the first genu and mastoid segment each in three cases. Erosion of tegmen and sigmoid sinus plate was identified in four (14%) and six cases(21%), respectively. There were three cases of intracranial complication, manifest as lateral sinus thrombosis in two cases and epidural abscess in one case. All these three cases had erosion of the sigmoid sinus plate. We experienced three cases of 'automastoidectomy' and two cases of 'impending automastoidectomy'. In both of these two conditions, the patterns of erosion of EAC were very similar. The only difference was that whether the spontaneous drainage of cholesteatomatous mass had occurred or not yet. At the end of this issue, we briefly comment the CT findings of recurrent cholesteatoma we experienced in three cases. We believe high- resolution CT is a very reliable method and should be the first step in the evaluation of cholesteatoma.

Kim, Hyung Jin; Chung, Hae Gyeong; Gong, Jae Chul; Jeon, Sea Young; Lim, Byeong Hoon; Kim, Jae Hyoung; Do, Young Soo; Chung, Sung Hoon [Gyeong Sang National University College of Medicine, Chinju (Korea, Republic of); Shin, Si Ok [Chungbuk National University College of Medicine, Chungju (Korea, Republic of)

1990-12-15

84

A case report of odontogenic myxoma with characteristic multilocular lesion  

Energy Technology Data Exchange (ETDEWEB)

Although odontogenic myxoma (OM) has various radiographic appearances, the characteristic features of OM are the multilocular radiolucent lesion, straight bony septa along the margin forming either square or triangular spaces. We present a case of OM in a 25-year old-male patient. Multilocular radiolucent lesion on the left mandible body showed tennis racket appearance. Cone beam computed tomography (CBCT) showed straight bony septa along the margin and cortical perforation. This CBCT features would have significantly contributed to allowing a diagnosis of OM. We think that this case shows characteristic radiographic features of odontogenic myxoma.

Lee, Byung Do; Lee, Wan; Paeng, Jun Young [Department of Oral and Maxillofacial Radiology, School of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Son, Hyun Jin [Department of Pathology, Eulji University School of Medicine, Daejeon (Korea, Republic of)

2009-03-15

85

A case report of odontogenic myxoma with characteristic multilocular lesion  

International Nuclear Information System (INIS)

Although odontogenic myxoma (OM) has various radiographic appearances, the characteristic features of OM are the multilocular radiolucent lesion, straight bony septa along the margin forming either square or triangular spaces. We present a case of OM in a 25-year old-male patient. Multilocular radiolucent lesion on the left mandible body showed tennis racket appearance. Cone beam computed tomography (CBCT) showed straight bony septa along the margin and cortical perforation. This CBCT features would have significantly contributed to allowing a diagnosis of OM. We think that this case shows characteristic radiographic features of odontogenic myxoma.

2009-01-01

86

Varicocele treatment: A 2-centers comparison between non microsurgical open correction, laparoscopic approach and retrograde percutaneous sclerotization on 463 cases.  

Science.gov (United States)

Objectives: To determine whether there are differences in sperm parameters improvement after different varicocele correction techniques. To determine the role of age in sperm parameters improvement. Methods: 2 different European centers collected pre- and postoperative sperm parameters of patients undergoing varicocele correction. Among 463 evaluated patients, 367 were included. Patients were divided in procedure-related and age-related groups. Ivanissevich inguinal open surgical procedure (OS), lymphatic-sparing laparoscopic approach (LSL) and retrograde percutaneous transfemoral sclerotization (RPS) were performed. As outcome measurements sperm count (millions/mL, SC) and percentage of mobile sperms were analyzed. Univariate and multivariate regression between the defined groups; bivariate regression analysis between age and sperm count and motility. Results: Number of patients: OS 78; LSL 85; RPS 204. Mean age 30.2 (SD 6.83); postoperative SC increased from 18.2 to 30.1 (CI 95% 27.3-32.9; p Varicocele correction is confirmed useful in improving sperm parameters; sclerotization technique leads to a better sperm improvement compared to other studied procedures; improvement in seminal parameters is not affected by age of the patients treated. PMID:24085237

Ollandini, Giangiacomo; Liguori, Giovanni; Ziaran, Stanislav; Málek, Tomáš; Mazzon, Giorgio; De Concilio, Bernardino; Bucci, Stefano; Benvenuto, Sara; Belgrano, Emanuele; Trombetta, Carlo

2013-09-26

87

Bony fragments in the uterus: an association with secondary subfertility.  

Science.gov (United States)

Bone within the uterine cavity is an unusual finding in women with secondary subfertility, and is usually associated with a past history of termination of pregnancy. The etiology is unknown, but theories include retained fetal bone and osseous metaplasia of endometrial tissue. We describe the cases of three subfertility patients, all with a history of surgical termination of pregnancy. Each patient underwent a hysteroscopy after highly echogenic foci were seen in the uterus on transvaginal ultrasound examination. During hysteroscopy, several coral-like bony fragments were seen and removed by sharp curettage. On histological examination, these fragments were found to be mature, necrotic bone. This case report confirms the importance of routine baseline evaluation of the endometrium in subfertile women with a history of termination of pregnancy. PMID:14528478

Basu, M; Mammen, C; Owen, E

2003-10-01

88

Inverted 'V' osteotomy excision arthroplasty for bony ankylosed elbows  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Bony ankylosis of elbow is challenging and difficult problem to treat. The options are excision arthroplasty and total elbow replacement. We report our midterm results on nine patients, who underwent inverted 'V' osteotomy excision arthroplasty in our hospital with good functional results. Materials Our case series includes 9 patients (seven males and two females) with the mean age of 34 years (13-56 years). Five patients had trauma, two had pyogenic arthritis, one had tuberculous arthritis, and one had pyogenic arthritis following surgical fixation. Results The average duration of follow up is 65 months (45 months-80 months). The mean Mayo's elbow performance score (MEPS) preoperatively was 48 (35-70). The MEPS at final follow up was 80 (60-95). With no movement at elbow and fixed in various degrees of either flexion or extension preoperatively, the mean preoperative position of elbow was 64°(30°to 100°). The mean post operative range of motion at final follow up was 27°of extension (20-500), 116°of flexion (1100-1300), and the arc of motion was 88°(800-1000). One patient had ulnar nerve neuropraxia and another patient developed median nerve neuropraxia, and both recovered completely in six weeks. No patient had symptomatic instability of the elbow. All patients were asymptomatic except one patient, who had pain mainly on heavy activities. Conclusion We conclude that inverted 'V' osteotomy excision arthroplasty is a viable option in the treatment of bony ankylosis of the elbow in young patients.

Rex Chadrabose; Periyasamy Rameshkumar; Balaji Subbachandra; C Premanand; Alva Shreyas; Reddy Shiva

2011-01-01

89

POEMS syndrome : two cases report  

Energy Technology Data Exchange (ETDEWEB)

Two patients with an unusual multisystemic syndrome characterized by polyneuropathy, organomegaly(especially hepatosplenomegaly), endocrine dysfunction, M-protein, and skin abnormalities(POEMS syndrome) are discussed.Characteristic radiographic features include hepatosplenomegaly, lymph node enlargement, sclerotic bony lesions,and a peculiar variety of bony proliferation.

Ko, Eun Young; Yang, Ik; Lee, Kyung Won; Lee, Yul; Chung, Soo Young; Lee, Eil Seoung [Hallym Univ. College of Medicine, Seoul (Korea, Republic of)

1998-07-01

90

Imaging of painful solitary lesions of the sacrum  

International Nuclear Information System (INIS)

[en] Full text: In patients with sacral pain, the painful symptoms may be caused by a variety of bony and soft tissue lesions. Benign lesions include giant cell tumour, neurogenic tumour, insufficiency fracture, infection and giant bone island. Malignant lesions include primary bone tumours, Ewing sarcoma, plasmacytoma, lymphoma and chordoma. Soft tissue tumours adjacent to or involving the sacrum may cause painful symptoms. A multimodality approach to imaging is required for full assessment of these lesions. This pictorial essay describes a range of common solitary sacral lesions that may cause pain, with emphasis on imaging features

2007-01-01

91

Varicocele treatment: A 2-centers comparison between non microsurgical open correction, laparoscopic approach and retrograde percutaneous sclerotization on 463 cases.  

UK PubMed Central (United Kingdom)

Objectives: To determine whether there are differences in sperm parameters improvement after different varicocele correction techniques. To determine the role of age in sperm parameters improvement. Methods: 2 different European centers collected pre- and postoperative sperm parameters of patients undergoing varicocele correction. Among 463 evaluated patients, 367 were included. Patients were divided in procedure-related and age-related groups. Ivanissevich inguinal open surgical procedure (OS), lymphatic-sparing laparoscopic approach (LSL) and retrograde percutaneous transfemoral sclerotization (RPS) were performed. As outcome measurements sperm count (millions/mL, SC) and percentage of mobile sperms were analyzed. Univariate and multivariate regression between the defined groups; bivariate regression analysis between age and sperm count and motility. Results: Number of patients: OS 78; LSL 85; RPS 204. Mean age 30.2 (SD 6.83); postoperative SC increased from 18.2 to 30.1 (CI 95% 27.3-32.9; p < 0,001); motility from 25.6 to 32.56% (30.9-34.2; p < 0.001). OS: SC varied from 16.9 to 18.2 (p < 0.001); sperm motility from 29% to 33% (p < 0.001). LSL: SC from 15.5 to 17.2 (p < 0.001); motility from 27 to 31% (p < 0.001). RPS: SC from 18.9 to 36.2 (p < 0.001); motility from 24% to 32% (p < 0.001). Univariate and multivariate analysis confirmed the significant difference of SC variation in RPS, compared to the other groups (p < 0.001). No significance between LSL and OS (p = 0.826). No significant differences regarding motility (p = 0.8). Conclusions: Varicocele correction is confirmed useful in improving sperm parameters; sclerotization technique leads to a better sperm improvement compared to other studied procedures; improvement in seminal parameters is not affected by age of the patients treated.

Ollandini G; Liguori G; Ziaran S; Málek T; Mazzon G; De Concilio B; Bucci S; Benvenuto S; Belgrano E; Trombetta C

2013-09-01

92

Reliability of bony landmarks for restoration of the joint line in revision knee arthroplasty.  

Science.gov (United States)

The aim of this study was to determine the reliability of bone landmarks for restoring the joint line in revision knee arthroplasty. The relationship of the femoral epicondyles, the tibial tubercle (TT) and the fibular head (FH) to the joint line was measured on 200 magnetic resonance imaging (MRI, 100 females, 100 males), including assessment on intraobserver and interobserver reliability. MRI scans demonstrating chondral lesions and osteoarthritis were excluded, as were patients with immature skeletons or a history of previous knee surgery. Sequences in sagittal, coronal and axial planes were used as well as cross-referencing with the same computer software. In order to account for size differences between patients, each bony landmark measurement was converted to a ratio relative to the femoral or/and tibial width. We found a transepicondylar axis equal to 3.11 degrees (+/-1.9). The average distance from the epicondyles to the joint line was respectively 23 mm on the lateral side and 28 mm on the medial side. However there was a variation of distance from the epicondyles of the joint line up to 11 mm and a significative difference was found between male and female. We determined the distances from the tip of the FH and from the TT to the joint line. The joint line-FH distance averaged 14 mm (range 4.1-22.13) with no gender difference. The joint line-TT distance was averaged 22 mm (range 10.61-32.09). We determined an epicondylar ratio (distance from the lateral epicondyle to the joint line related to the femoral width). We found this ratio averaged 28% with no gender difference (P = 0.09). There is a large variation of bony landmarks depending on the size of the individual. Considering this findings, the FH is not a reliable guide for the joint line in revision surgery. Previous studies have measured the absolute values from various landmarks to the joint line. This study provides a significant advantage, in that the level of the joint line can be determined for each individual by using a ratio to account for gender and size differences. PMID:18046537

Servien, Elvire; Viskontas, Darius; Giuffrè, Bruno M; Coolican, Myles R J; Parker, David A

2007-11-29

93

Surgical induction of TMJ bony ankylosis in growing sheep and the role of injury severity of the glenoid fossa on the development of bony ankylosis.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The purpose of this paper is to summarize our experiences in creating an animal model of TMJ bony ankylosis based on 2 sequential experiments. METHODS: Two sequential experiments were performed with the aim of creating a model of TMJ bony ankylosis. Seven growing sheep were used in the first experiment, in which 1 was served as a control animal. Condylar fracture with disc preservation was performed on the control side. On the contralateral side, condylar fracture, excision of the lateral 2/3 disc and injury to the glenoid fossa were performed to induce bony ankylosis. Three animals were sacrificed respectively at 3 and 6months after surgery. In the second experiment, 7 growing sheep were used. The only difference of modeling between the 2 experiments was that more serious injury to the glenoid fossa was made in the ankylosis-induced side in experiment 2. Three, 2, and 2 animals were sacrificed respectively at 1, 3, and 6months postoperatively. The TMJ complexes were examined by computed tomography (CT) and histological evaluation. RESULTS: In experiment 1, only fibrous ankylosis was observed in the ankylosis-induced side both at 3 and 6months postoperatively. In experiment 2, CT and histological evaluation showed that the outcomes of the ankylosis-induced side were fibrous-bony ankylosis, fibrous-bony ankylosis, and bony ankylosis respectively at 1, 3, and 6months after surgery. CONCLUSION: Through summarizing the differences of the modeling and the different outcomes in the 2 experiments, we concluded that severe damage to the glenoid fossa played an important role in the development of TMJ bony ankylosis.

Yan YB; Zhang Y; Gan YH; An JG; Li JM; Xiao E

2013-09-01

94

Bony variations on coronary CT cuts of the paranasal sinuses  

International Nuclear Information System (INIS)

[en] Bony variations in the anterior ethmoids may, if severe, play an important role in the development of chronic sinusitis and present the surgeon with added risks during operation. We have, therefore, analysed 390 preoperative CT examinations of the sinuses performed in the coronary plane with respect to the frequency of bone variations. Concha bullosa, increased pneumatisation of the agger nasi, large ethmoidal bullae, Haller's cells and increased pneumatisation of the sphenoid were found with equal frequency in about 20%. The most common variants occurred in the uncinate process (31.5%), less common were paradoxical curve of the middle turbinates (13.3%) and very rare were Onodi cells (1.3%). (orig.)[de] Knoecherne Variationen im anterioren Ethmoid koennen je nach Auspraegungsgrad fuer die Genese einer chronischen Sinusitis eine wichtige Rolle spielen bzw. fuer eine endonasale Operation Gefahrenpunkte darstellen. Wir analysierten deshalb 380 unserer praeoperativ durchgefuehrten koronaren Nasennebenhoehlencomputertomogramme im Hinblick auf die Haeufigkeit knoecherner Varianten. Mit etwa 20% zeigten die Concha bullose, die stark pneumatisierte Agger-nasi-Zelle, die uebergrosse Bulla ethmoidalis, Hallersche Zellen sowie vermehrte Keilbeinhoehlenpneumatisationen eine aehnliche Verteilung. Am haeufigsten fanden wir Processus-uncinatus-Variationen (31,5%), seltener paradox gebogene mittlere Nasenmuscheln (13,3%) bzw. sehr selten Onodi-Zellen (1,3%). (orig.)

1993-01-01

95

Viral vaccines for bony fish: past, present and future.  

UK PubMed Central (United Kingdom)

Since 1970, aquaculture production has grown. In 2010, it had an annual average rate of 6.3% with 59.9 million tons of product and soon could exceed capture fisheries as a source of fishery products. However, the occurrence of viral diseases continues to be a significant limiting factor and its control is important for the development of this sector. In aquaculture farms, fish are reared under intensive culture conditions, and the use of viral vaccines has enabled an increase in production. Several types of vaccines and strategies of vaccination have been developed; however, this approach has not reached the expected goals in the most susceptible stage (fingerlings). Currently, there are inactivated and recombinant commercial vaccines, mainly for salmonids and cyprinids. In addition, updated genomic and proteomic technology has expedited the research and expansion of new vaccine models, such as those comprised of subunits or DNA. The objective of this review is to cover the various types of viral vaccines that have been developed and are available for bony fishes, as well as the advantages and challenges that DNA vaccines present for massive administration in a growing aquaculture, possible risks for the environment, the controversy regarding genetically modified organisms and possible acceptance by consumers.

Salgado-Miranda C; Loza-Rubio E; Rojas-Anaya E; García-Espinosa G

2013-05-01

96

Adamantinoma of the tibia mimicking a benign cystic lesion: a case report.  

Science.gov (United States)

Adamantinoma of the long bones is a rare primary malignant bone tumor accounting for less than 1% of all primary malignant bone tumors. Most typical imaging findings include heterogeneous osteolytic cortical lesions showing multiple sharply circumscribed lucent zones of various sizes with sclerotic bone surroundings, interspersing between, and extending above and below the lucent zones by the thinning and bulging cortex. Advanced or recurrent lesions may be associated with destruction of the cortex and soft tissue extension. In this article, the authors present a case report of a patient with a distal tibia adamantinoma mimicking a benign cystic lesion. PMID:19963177

Mavrogenis, Andreas F; Galanakos, Spyridon; Savvidou, Olga D; Papagelopoulos, Panayiotis J

2010-01-01

97

Adamantinoma of the tibia mimicking a benign cystic lesion: a case report.  

UK PubMed Central (United Kingdom)

Adamantinoma of the long bones is a rare primary malignant bone tumor accounting for less than 1% of all primary malignant bone tumors. Most typical imaging findings include heterogeneous osteolytic cortical lesions showing multiple sharply circumscribed lucent zones of various sizes with sclerotic bone surroundings, interspersing between, and extending above and below the lucent zones by the thinning and bulging cortex. Advanced or recurrent lesions may be associated with destruction of the cortex and soft tissue extension. In this article, the authors present a case report of a patient with a distal tibia adamantinoma mimicking a benign cystic lesion.

Mavrogenis AF; Galanakos S; Savvidou OD; Papagelopoulos PJ

2010-01-01

98

Algodystrophy in children and young adults with isotopic bony hypofixation. A propos of 5 observations  

Energy Technology Data Exchange (ETDEWEB)

The authors report 5 observations of young adults 3 teen-agers and 2 children suffering from algodystrophy, and in whom isotopic exploration of the skeleton disclosed a clear bony hypofixation during the entire evolution. These observations confirm their 1981 work concerning a young adult suffering from algodystrophy with isotopic bony hypofixation. Recent Canadian and American studies emphasize also the frequency of isotopic hypofixation in children algodystrophy. It seems, therefore, that isotopic bony hypofixation (linked perhaps to a decreased blood flow), is rather specific of algodystrophy in young subjects.

Doury, P.; Pattin, S.; Eulry, F.; Granier, R.; Gaillard, F.

1986-12-01

99

CT image evaluation of the internal rotation limit prior to bony impingement after total hip arthroplasty  

Energy Technology Data Exchange (ETDEWEB)

This study evaluated the internal rotation limit prior to bony impingement of the proximal femur on the pelvis after total hip arthroplasty (THA). Reconstructed computed tomography (CT) images of 90 deg hip flexion were used to simulate the internal rotation limit against safety limits measured intraoperatively. Ninety joints in 86 subjects (12 men and 74 women) underwent THA for the treatment of secondary coxarthrosis. The correlation between the internal rotation limit prior to the bony impingement intraoperatively and the simulated internal rotation angle on the reconstructed CT image was statistically significant. We provide a new method to simulate the internal rotation limit prior to bony impingement based on postoperative CT. (author)

Suzuki, Koji; Matsubara, Masaaki; Morita, Sadao; Muneta, Takeshi; Shinomiya, Ken-ichi [Tokyo Medical and Dental Univ. (Japan). School of Medicine

2002-07-01

100

CT image evaluation of the internal rotation limit prior to bony impingement after total hip arthroplasty  

International Nuclear Information System (INIS)

[en] This study evaluated the internal rotation limit prior to bony impingement of the proximal femur on the pelvis after total hip arthroplasty (THA). Reconstructed computed tomography (CT) images of 90 deg hip flexion were used to simulate the internal rotation limit against safety limits measured intraoperatively. Ninety joints in 86 subjects (12 men and 74 women) underwent THA for the treatment of secondary coxarthrosis. The correlation between the internal rotation limit prior to the bony impingement intraoperatively and the simulated internal rotation angle on the reconstructed CT image was statistically significant. We provide a new method to simulate the internal rotation limit prior to bony impingement based on postoperative CT. (author)

2002-01-01

 
 
 
 
101

Algodystrophy in children and young adults with isotopic bony hypofixation. A propos of 5 observations  

International Nuclear Information System (INIS)

The authors report 5 observations of young adults 3 teen-agers and 2 children suffering from algodystrophy, and in whom isotopic exploration of the skeleton disclosed a clear bony hypofixation during the entire evolution. These observations confirm their 1981 work concerning a young adult suffering from algodystrophy with isotopic bony hypofixation. Recent Canadian and American studies emphasize also the frequency of isotopic hypofixation in children algodystrophy. It seems, therefore, that isotopic bony hypofixation (linked perhaps to a decreased blood flow), is rather specific of algodystrophy in young subjects.

1986-01-01

102

First histologically confirmed case of a classic chordoma arising in a precursor benign notochordal lesion: differential diagnosis of benign and malignant notochordal lesions  

Energy Technology Data Exchange (ETDEWEB)

The first histologically confirmed case of a classic chordoma arising in a precursor benign notochordal lesion is presented and the differential diagnosis between benign and malignant notochordal lesions is discussed. A 57-year-old man presented with a classic chordoma in the coccyx. The resected specimen demonstrated a small intraosseous benign notochordal lesion in the coccyx, which was adjacent to the classic chordoma. Also seen were two separate, similar benign lesions in the sacrum. The classic chordoma consisted of multiple lobules that were separated by thin fibrous septa and that showed cords or strands of atypical physaliphorous cells set within an abundant myxoid matrix. In contrast, the benign lesions consisted of intraosseous sheets of bland physaliphorous cells without any extracellular matrix. The affected bone trabeculae showed sclerotic reactions. It was concluded that benign and malignant notochordal lesions can be distinguished microscopically. (orig.)

Yamaguchi, Takehiko [Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine, Mibu, Tochigi (Japan); Yamato, Minoru [Department of Radiology, International Catholic Hospital, Tokyo (Japan); Saotome, Koichi [Department of Orthopaedic Surgery, Dokkyo University School of Medicine, Mibu, Tochigi (Japan)

2002-07-01

103

The correlation between pretreatment serum hormone levels and treatment outcome for patients with prostatic cancer and bony metastasis.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate whether pretreatment serum hormone levels are a prognostic factor for prostatic cancer with bony metastasis under hormonal treatment. PATIENTS AND METHODS: Between 1980 and 1994, 96 patients with prostate cancer and bony metastasis were included for an evaluation by a retrospective review of their charts. All 96 had received hormonal treatment after a diagnosis of metastatic prostatic carcinoma. Serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin were assessed before treatment. The patients were divided into two groups according to their response during the follow-up. Group 1 (good response) had no change or resolution of metastatic lesion(s) on the bone scan and a declining prostate-specific antigen (PSA) level. Group 2 had increased PSA or progression of metastatic lesion(s) on the bone scan. Tumours were graded as low (2-4), intermediate (5-7) and high (8-10) using the Gleason score. RESULTS: There were 43 patients in group 1 and 53 in group 2; the overall mean (sd) age was 72.5 (6.8) years and the follow-up 29.5 (0.5) months. The respective mean (sd) levels of testosterone, LH, FSH and prolactin before treatment were 4.6 (1.6) ng/mL, 20.2 (13.3) mIU/mL, 19.6 (18.6) mIU/mL and 20.7 (12.1) ng/mL in group 1, and 2.6 (1.0) ng/mL, 27.3 (11.0) mIU/mL, 27.1 (9.8) mIU/mL and 41.3 (28.4) ng/mL in group 2. The level of testosterone was significantly higher in group 1 than in group 2, while LH, FSH and prolactin were significantly lower in group 1 than in group 2. When stratified by tumour grade, patients in group 1 still had significantly higher pretreatment testosterone and lower LH, FSH and prolactin than those in group 2. CONCLUSION: Higher testosterone and lower LH, FSH and prolactin levels were good prognostic factors for patients with metastatic prostatic cancer under hormonal treatment, irrespective of tumour grading.

Chen SS; Chen KK; Lin AT; Chang YH; Wu HH; Chang LS

2002-05-01

104

Different pattern of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma.  

UK PubMed Central (United Kingdom)

Changes in the process of cross-linking of collagen molecules are associated with defects in the biomechanical stability of the extracellular matrix. Fibrosis of skin is characterized by an increase in pyridinolines, which are hydroxylysine aldehyde derived cross-links usually absent in healthy skin. In this study, we analyzed cross-links in lipodermatosclerosis and localized scleroderma to address the question whether all the mature cross-links currently characterized are increased in fibrosis in addition to the increase in pyridinolines. As psoralen plus ultraviolet A treatment leads to clinical improvement of fibrotic plaques in localized scleroderma we analyzed the cross-link content in lesional skin after bath psoralen plus ultraviolet A therapy. In skin from patients with localized scleroderma an increase in the total number of mature cross-links was found to be due to an increase in both pyridinolines and dehydro-histidinohydroxymerodesmosine. The concentration of histidinohydroxylysinonorleucine was unchanged. By contrast, the total number of mature cross-links was decreased in lipodermatosclerosis. This decrease was caused by a decrease of lysine aldehyde derived cross-links (dehydro-histidinohydroxymerodesmosine and histidinohydroxylysinonorleucine), whereas the concentration of pyridinolines increased. A decrease in the content of pyridinolines after bath psoralen plus ultraviolet A treatment was found in six out of nine patients with localized scleroderma, which might reflect a remodeling of the extracellular matrix. Our data provide evidence that sclerosis of skin is associated with either an increase in the number of cross-links per molecule of collagen or a change in the molecular nature of the cross-links formed.

Brinckmann J; Neess CM; Gaber Y; Sobhi H; Notbohm H; Hunzelmann N; Fietzek PP; Müller PK; Risteli J; Gebker R; Scharffetter-Kochanek K

2001-08-01

105

Different pattern of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma.  

Science.gov (United States)

Changes in the process of cross-linking of collagen molecules are associated with defects in the biomechanical stability of the extracellular matrix. Fibrosis of skin is characterized by an increase in pyridinolines, which are hydroxylysine aldehyde derived cross-links usually absent in healthy skin. In this study, we analyzed cross-links in lipodermatosclerosis and localized scleroderma to address the question whether all the mature cross-links currently characterized are increased in fibrosis in addition to the increase in pyridinolines. As psoralen plus ultraviolet A treatment leads to clinical improvement of fibrotic plaques in localized scleroderma we analyzed the cross-link content in lesional skin after bath psoralen plus ultraviolet A therapy. In skin from patients with localized scleroderma an increase in the total number of mature cross-links was found to be due to an increase in both pyridinolines and dehydro-histidinohydroxymerodesmosine. The concentration of histidinohydroxylysinonorleucine was unchanged. By contrast, the total number of mature cross-links was decreased in lipodermatosclerosis. This decrease was caused by a decrease of lysine aldehyde derived cross-links (dehydro-histidinohydroxymerodesmosine and histidinohydroxylysinonorleucine), whereas the concentration of pyridinolines increased. A decrease in the content of pyridinolines after bath psoralen plus ultraviolet A treatment was found in six out of nine patients with localized scleroderma, which might reflect a remodeling of the extracellular matrix. Our data provide evidence that sclerosis of skin is associated with either an increase in the number of cross-links per molecule of collagen or a change in the molecular nature of the cross-links formed. PMID:11511304

Brinckmann, J; Neess, C M; Gaber, Y; Sobhi, H; Notbohm, H; Hunzelmann, N; Fietzek, P P; Müller, P K; Risteli, J; Gebker, R; Scharffetter-Kochanek, K

2001-08-01

106

Unusual cause of generalized osteolytic vertebral lesions: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Vertebral sarcoidosis is an extremely rare form of osseous sarcoidosis. Although osseous sarcoidosis is almost always an incidental finding of sarcoidosis elsewhere in the body, vertebrae may be the primary disease site. Involvement of vertebrae is usually localized and sclerotic or lytic. Case presentation We describe a case of extensive asymptomatic vertebral involvement by sarcoid with osteolytic lesions. Making the diagnosis requires biopsy and ruling out other commoner causes of osteolytic vertebral lesions. Conclusion We report this case in the hope of expanding the knowledge of osseous sarcoidosis. Our patient was unique in that all involvement was axial with sparing of the peripheral skeleton, near absence of any other organ involvement, diffuse involvement of the whole spine and osteolytic bone lesions.

Nanda Sudip; Bhatt Surya; Steinberg David; Volk Stephen A

2007-01-01

107

Esclerosis inflamatoria orbitaria y síndrome de fibrosis multifocal/ Sclerotic inflammation of the orbit and multifocal fibrosclerosis syndrome  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Caso clínico: Mujer de 52 años que consulta en nuestro Servicio por proptosis bilateral. La aparición de sintomatología aguda digestiva durante el ingreso para el estudio de la proptosis, condujo al diagnóstico de un cuadro de fibroesclerosis multifocal, con afectación simultánea de los tejidos orbitarios, grasa mesentérica y tronco de encéfalo. Discusión: El pseudotumor esclerosante orbitario es una rara entidad clinicopatológica, cuyas características en la (more) clínica y en las pruebas de imagen pueden ser similares a las del pseudotumor inflamatorio idiopático. El diagnóstico diferencial es importante porque ambos difieren tanto en su tratamiento como en su pronóstico. Abstract in english Clinical case: A fifty-two-year-old woman consulted our department because of a bilateral proptosis. The appearance of acute symptoms suggestive of a digestive disorder during her admission to hospital for the study of the proptosis, led to a diagnosis of multifocal fibrosclerosis with simultaneous affliction of orbital tissue, mesenteric fat and the brain stem. Discussion: Idiopathic Sclerotic Inflammation of the orbit is a rare pathological entity, with similar clinical (more) and radiological characteristics to orbital pseudo-tumour. The differential diagnosis is important because both these conditions differ in treatment and prognosis.

Mataix, B.; López-Navarrete, E.; López-Domínguez, M.; Ángeles, R.

2008-04-01

108

Esclerosis inflamatoria orbitaria y síndrome de fibrosis multifocal Sclerotic inflammation of the orbit and multifocal fibrosclerosis syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available Caso clínico: Mujer de 52 años que consulta en nuestro Servicio por proptosis bilateral. La aparición de sintomatología aguda digestiva durante el ingreso para el estudio de la proptosis, condujo al diagnóstico de un cuadro de fibroesclerosis multifocal, con afectación simultánea de los tejidos orbitarios, grasa mesentérica y tronco de encéfalo. Discusión: El pseudotumor esclerosante orbitario es una rara entidad clinicopatológica, cuyas características en la clínica y en las pruebas de imagen pueden ser similares a las del pseudotumor inflamatorio idiopático. El diagnóstico diferencial es importante porque ambos difieren tanto en su tratamiento como en su pronóstico.Clinical case: A fifty-two-year-old woman consulted our department because of a bilateral proptosis. The appearance of acute symptoms suggestive of a digestive disorder during her admission to hospital for the study of the proptosis, led to a diagnosis of multifocal fibrosclerosis with simultaneous affliction of orbital tissue, mesenteric fat and the brain stem. Discussion: Idiopathic Sclerotic Inflammation of the orbit is a rare pathological entity, with similar clinical and radiological characteristics to orbital pseudo-tumour. The differential diagnosis is important because both these conditions differ in treatment and prognosis.

B. Mataix; E. López-Navarrete; M. López-Domínguez; R. Ángeles

2008-01-01

109

Blue lesions.  

UK PubMed Central (United Kingdom)

Blue color is found in a wide range of malignant and benign melanocytic and nonmelanocytic lesions and in lesions that result from penetration of exogenous materials, such as radiation or amalgam tattoo or traumatic penetration of particles. Discriminating between different diagnostic entities that display blue color relies on careful patient examination and lesion assessment. Dermoscopically, the extent, distribution, and patterns created by blue color can help diagnose lesions with specificity and differentiate between benign and malignant entities. This article provides an overview of the main diagnoses whereby blue color can be found, providing simple management rules for these lesions.

Longo C; Scope A; Lallas A; Zalaudek I; Moscarella E; Gardini S; Argenziano G; Pellacani G

2013-10-01

110

Assessment of alveolar bone loss and angular bony defects on panoramic radiographs.  

UK PubMed Central (United Kingdom)

The aim of the present study was to investigate the prevalence and severity of alveolar bone loss and angular bony defects in randomly selected panoramic radiographs. A total of 500 panoramic radiographs of adult patients seeking dental care were studied. The mean age of the subjects was 51 years (range 20-80). The assessments of alveolar bone levels and angular bony defects were performed by direct measurements of the distance between the cemento-enamel junction (CEJ) and bone level. The results demonstrated a gradual and significant increase in the frequency of bone loss with increasing age (p<0.05). Angular bony defects were found in 249 subjects (49.8 %) and were most frequent at the mandibular first molar. The mean depth of the angular bony defects was 6.0 mm with the greatest mean depth in the maxillary anterior area (6.8 mm). The mean mesiodistal depth of the intrabony defects was 2.44 mm, most pronounced in maxillary molars (3.1 mm). In conclusion, the study demonstrated a high prevalence of angular bony defects suitable for regenerative periodontal treatment.

Kasaj A; Vasiliu Ch; Willershausen B

2008-01-01

111

Assessment of alveolar bone loss and angular bony defects on panoramic radiographs.  

Science.gov (United States)

The aim of the present study was to investigate the prevalence and severity of alveolar bone loss and angular bony defects in randomly selected panoramic radiographs. A total of 500 panoramic radiographs of adult patients seeking dental care were studied. The mean age of the subjects was 51 years (range 20-80). The assessments of alveolar bone levels and angular bony defects were performed by direct measurements of the distance between the cemento-enamel junction (CEJ) and bone level. The results demonstrated a gradual and significant increase in the frequency of bone loss with increasing age (p<0.05). Angular bony defects were found in 249 subjects (49.8 %) and were most frequent at the mandibular first molar. The mean depth of the angular bony defects was 6.0 mm with the greatest mean depth in the maxillary anterior area (6.8 mm). The mean mesiodistal depth of the intrabony defects was 2.44 mm, most pronounced in maxillary molars (3.1 mm). In conclusion, the study demonstrated a high prevalence of angular bony defects suitable for regenerative periodontal treatment. PMID:18226994

Kasaj, A; Vasiliu, Ch; Willershausen, B

2008-01-23

112

Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS) and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI), the 2-step self-etch Adper SE Bond (3MESPE) and the 35% phosphoric acid (3MESPE) from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE) were applied on the bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm 2 ) and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material) was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment), according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05). Results: The duplication of the conditioning time favored only the GO adhesive (p<0.05). Both application methods significantly increased the tubule area opening (p<0.05) compared to the controls. Conclusions: The efficacy of duplicating the conditioning time was only effective for the 1-step self-etch adhesive system tested.

Alexandra Patricia Mena-Serrano; Eugenio Jose Garcia; Miguel Muñoz Perez; Gislaine Cristine Martins; Rosa Helena Miranda Grande; Alessandro Dourado Loguercio; Alessandra Reis

2013-01-01

113

Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS) and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI), the 2-step self-etch Adper SE Bond (3MESPE) and the 35% phosphoric acid (3MESPE) from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE) were applied on th (more) e bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm 2 ) and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material) was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment), according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05). Results: The duplication of the conditioning time favored only the GO adhesive (p<0.05). Both application methods significantly increased the tubule area opening (p<0.05) compared to the controls. Conclusions: The efficacy of duplicating the conditioning time was only effective for the 1-step self-etch adhesive system tested.

Mena-Serrano, Alexandra Patricia; Garcia, Eugenio Jose; Perez, Miguel Muñoz; Martins, Gislaine Cristine; Grande, Rosa Helena Miranda; Loguercio, Alessandro Dourado; Reis, Alessandra

2013-04-01

114

Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To evaluate the effect of application time on the resin-dentin bond strength (µTBS) and etching pattern of adhesive systems applied on sclerotic dentine. MATERIAL AND METHODS: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI), the 2-step self-etch Adper SE Bond (3MESPE) and the 35% phosphoric acid (3MESPE) from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE) were applied on the bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm²) and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material) was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment), according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05). RESULTS: The duplication of the conditioning time favored only the GO adhesive (p<0.05). Both application methods significantly increased the tubule area opening (p<0.05) compared to the controls. CONCLUSIONS: The efficacy of duplicating the conditioning time was only effective for the 1-step self-etch adhesive system tested.

Mena-Serrano AP; Garcia EJ; Perez MM; Martins GC; Grande RH; Loguercio AD; Reis A

2013-03-01

115

Application of radionuclide SPECT imaging in assessment of bony defect repair  

International Nuclear Information System (INIS)

PURPOSE: To assess bony defect repair with SPECT imaging. METHODS: 40 New Zealand rabbits with 1.5 cm bony defect on bilateral radius were divided into 4 groups with different implantation: A, composites of bone morphogenetic protein (BMP) and fibrin, B, BMP, C, fibrin, D, no implantation as control. The defects were examined by multiphase imaging in different weeks after operation. RESULTS: The regenerative bone salt deposition was found one week after operation, the highest level of deposition was in group A, and the second in group B. The bone regeneration revealed by SPECT imaging was in concordance with the results of histological and radiological examination. CONCLUSION: The combination use of SPECT and routine examination can assess bony defect repair more accurately and earlier

1997-01-01

116

[Bony regrowth after major erosion of the maxillary following silastic malar augmentation. Case report].  

UK PubMed Central (United Kingdom)

Alloplastic malar augmentation has become a routine procedure associated with few complications. Among them, authors have described bony erosion and resorption. The case presented here illustrates an unusual case of maxillary bone erosion after silastic malar augmentation. Implants were surgically removed and no more surgical intervention was performed. After 15 months, contrast-enhanced CT scan has showed nearly complete bony regrowth to an almost normal state. Considering resorption phenomenons following silastic chin implants, Peled et al. reported no long-term sequellae after implant removal and bony regrowth to the presurgical state after 9 months. Accordingly, we conclude that these phenomenons, even spectacular, are always reversible after implants removal and that treatment should just consist in ablation of the offending prosthetic material.

Salmin JP; Wilk A; Barrière P

2012-06-01

117

Bony expansion in skeletal metastases from carcinoma of the prostate as seen by bone scintigraphy  

Energy Technology Data Exchange (ETDEWEB)

Carcinoma of the prostate often metastasizes to the skeletal system, the usual radiologic pattern being widespread patchy areas of increased density without change in the contour of the involved bones. Radionuclide correlation generally shows multiple foci of increased tracer activity. Less commonly, there is bony sclerosis with expansion of the diameter of the involved bone. Several cases of expansile skeletal metastases from carcinoma of the prostate have appeared in the literature but we know of no published descriptions of the radionuclide findings. We present three patients with carcinoma of the prostate who had skeletal metastases with evidence of bony expansion on both roentgenographic and radionuclide examination. 15 references, 8 figures.

Resnik, C.S.; Garver, P.; Resnick, D.

1984-10-01

118

Surgical repair of a mandibular bony defect following the removal of an amelobalstoma  

Science.gov (United States)

This case report describes a 35-year-old Caucasian radiographer who presented with a significant mandibular bony defect following multiple excisions of an ameloblastoma. As a result, there was an absence of teeth on the lower-right mandible and a clear defect in the mandible. The treatment objectives were to rebuild the mandibular defect, with a long-term view of inserting dental implants. In a novel approach outlined in this presentation, tissue expansion of the submucosa, a titanium construct and an iliac bone graft were used to rebuild the patient’s jaw. This surgical technique is recommended for the reconstruction of bony defects.

Ejiofor, Kandi

2013-01-01

119

MRI findings of cyclops lesions of the knee  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english Cyclops lesions develop in the anterior aspect of the intercondylar notch typically after anterior cruciate ligament (ACL) reconstruction or injury. It is a lesion consisting of fibrous tissue with or without cartilage and bony components. A cyclops lesion is one of the causes for reduced extension and, in the cases reported here, also knee pain or discomfort after ACL reconstruction. We present the MRI features, particularly the features on proton density weighted turbo (more) spin echo (PDW TSE) and proton density weighted turbo spin echo fat saturation (PDW TSE FS) sequences of four cases of cyclops lesions, and distinguish between the MRI findings of large and small lesions. We also describe a cyclops lesion after a posterior cruciate ligament reconstruction, not described in literature before.

Minné, C; Velleman, MD; Suleman, FE

2012-04-01

120

A new flea, Ectinorus (Ectinorus) insignis n. sp. (Siphonaptera, Rhopalopsyllidae, Parapsyllinae), with notes on the subgenus Ectinorus in Chile and comments on unciform sclerotization in the superfamily Malacopsylloidea.  

UK PubMed Central (United Kingdom)

A list is provided for the species of Ectinorus sensu stricto from Chile. Ectinorus (Ectinorus) insignis n. sp. is described from Chile: this species is characterized by the male genitalia. In the subgenus Ectinorus, the authors report the presence in Chile of E. pilosus Beaucournu & Carmen Castro, 2002 described from Argentina and E. simonsi (Rothschild, 1904) described from Bolivia but also known from Peru. A female neallotype is designated for E. ineptus Johnson, 1957. "Unciform sclerotization" is noted and illustrated for the first time, in all Malacopsylloidea, and a list is given for all studied species.

Beaucournu JC; Belaz S; Muñoz-Léal S; González-Acuña D

2013-01-01

 
 
 
 
121

[Immunofluorescent demonstration of pancreatic polypeptide (PP) in pancreas and digestive tube of bony and cartilaginous fish  

UK PubMed Central (United Kingdom)

When antisera specific against bovine PP (BPP) were used, immunoreactive parenchymal cells were observed in the endocrine pancreas and in the gastro-intestinal tract of the teleost bony fish Cottus scorpius, as well as in the pancreas of the elasmobranchian cartilaginous fish Squalus acanthias. Of the two principal islets of Cottus, PP-cells were located selectively to that in the pyloric region.

Stefan Y; Dufour C; Falkmer S

1978-04-01

122

Effect of disc displacement on the bony change and disc configuration of TMJ  

International Nuclear Information System (INIS)

The objective of this study was to investigate the effect of TMJ disc displacement on the TMJ disc configuration and surrounding osseous structure. The proton density and T2-weighted MR images of 57 TMJs were retrospectively studied. These TMJs were divided into three groups according to the anterior disc displacement status an MR sagittal images, those were the normal, anterior disc displacement with reduction (ADWR), anterior disc displacement without reduction (ADWOR). The frequency of disc configuration and surrounding bony change, the border status between articular disc and retrodiscal tissue were investigated according to the positional change of articular disc. There were significant statistical differences of chi-square of TMJ disc configurational type between normal and ADWR/ADWOR group, respectively. Surrounding bony change frequently appeared in ADWOR and a statistically significant difference of chi-square statistics of bony change frequency between normal and ADWOR group was observed. These results suggested that the disc configuration and bony change of TMJ are strongly related to TMJ disc displacement.

2006-01-01

123

Effect of disc displacement on the bony change and disc configuration of TMJ  

Energy Technology Data Exchange (ETDEWEB)

The objective of this study was to investigate the effect of TMJ disc displacement on the TMJ disc configuration and surrounding osseous structure. The proton density and T2-weighted MR images of 57 TMJs were retrospectively studied. These TMJs were divided into three groups according to the anterior disc displacement status an MR sagittal images, those were the normal, anterior disc displacement with reduction (ADWR), anterior disc displacement without reduction (ADWOR). The frequency of disc configuration and surrounding bony change, the border status between articular disc and retrodiscal tissue were investigated according to the positional change of articular disc. There were significant statistical differences of chi-square of TMJ disc configurational type between normal and ADWR/ADWOR group, respectively. Surrounding bony change frequently appeared in ADWOR and a statistically significant difference of chi-square statistics of bony change frequency between normal and ADWOR group was observed. These results suggested that the disc configuration and bony change of TMJ are strongly related to TMJ disc displacement.

Kim, Jin Hoa; Lee, Wan; Lee, Byung Do [Wonkwang University, Iksan (Korea, Republic of)

2006-03-15

124

Condylar bony changes in patients with temporomandibular disorders: a CBCT study  

Energy Technology Data Exchange (ETDEWEB)

Diagnosis of osteoarthritis most commonly depends on clinical and radiographic findings. The present study attempted to observe the bony changes in temporomandibular joint (TMJ) patients from all age groups. The first-visit clinical records and cone beam computed tomography (CBCT) data of 440 TMJs from 220 consecutive TMJ patients were reviewed retrospectively. The most frequent condylar bony change observed was sclerosis (133 joints, 30.2%) followed by surface erosion (129 joints, 29.3%), flattening of the articular surface (112 joints, 25.5%), and deviation in form (58 joints, 13.2%), which included 33 TMJs in a cane-shape, 16 with a lateral or medial pole depression, 6 with posterior condylar surface flattening, and 3 with a bifid-shaped condyle. Fifty-three joints (12.0%) showed hypoplastic condyles but only 1 joint showed hyperplasia. Osteophyte was found in 35 joints (8.0%) and subcortical cyst in 24 joints (5.5%), 5 of which had surface erosion as well. One hundred nineteen joints (27.0%) had only one kind of condylar bony change, 66 joints (15.0%) had two, 52 joints (11.8%) had three, 12 joints (5.0%) had four, and 6 joints (1.4%) had five kinds of condylar bony changes at the same time. Eighty-five (65.9%) of 129 joints with surface erosion had pain recorded at the chief complaint. With more widespread use of CBCT, more specific or detailed guidelines for osteoarthritis are needed.

Nah, Kyung Soo [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Pusan National University, Yangsan (Korea, Republic of)

2012-09-15

125

Condylar bony changes in patients with temporomandibular disorders: a CBCT study  

International Nuclear Information System (INIS)

Diagnosis of osteoarthritis most commonly depends on clinical and radiographic findings. The present study attempted to observe the bony changes in temporomandibular joint (TMJ) patients from all age groups. The first-visit clinical records and cone beam computed tomography (CBCT) data of 440 TMJs from 220 consecutive TMJ patients were reviewed retrospectively. The most frequent condylar bony change observed was sclerosis (133 joints, 30.2%) followed by surface erosion (129 joints, 29.3%), flattening of the articular surface (112 joints, 25.5%), and deviation in form (58 joints, 13.2%), which included 33 TMJs in a cane-shape, 16 with a lateral or medial pole depression, 6 with posterior condylar surface flattening, and 3 with a bifid-shaped condyle. Fifty-three joints (12.0%) showed hypoplastic condyles but only 1 joint showed hyperplasia. Osteophyte was found in 35 joints (8.0%) and subcortical cyst in 24 joints (5.5%), 5 of which had surface erosion as well. One hundred nineteen joints (27.0%) had only one kind of condylar bony change, 66 joints (15.0%) had two, 52 joints (11.8%) had three, 12 joints (5.0%) had four, and 6 joints (1.4%) had five kinds of condylar bony changes at the same time. Eighty-five (65.9%) of 129 joints with surface erosion had pain recorded at the chief complaint. With more widespread use of CBCT, more specific or detailed guidelines for osteoarthritis are needed.

2012-01-01

126

Observation of maxillary sinus septa and bony bridges using dry skulls between Hellman's dental age of IA and IIIC.  

Science.gov (United States)

Maxillary sinus septa and bony bridges were observed using dry skulls in childhood, classified based on Hellman's dental age, to clarify maxillary sinus septum formation. Eighty-eight maxillary sinuses of 44 dry skulls and a cone-beam computed tomography (CBCT) unit were used. The locations of the septum, defined as a pointed bony structure originating from the inferior wall, and bony bridge, defined as a bony structure between the maxillary sinus wall and dental germ, were antero-posteriorly recorded, and the superoinferior distance, distance from the bony palate, and angle to the median palatine suture were measured. The rate of septum presence in the maxillary sinus was high (41.7%) in IIIC, and the septa were located in the deciduous molars, premolars, and molars. Also, all bony bridges were related to the median maxillary sinus wall, and the rate of the maxillary sinus showing a bony bridge was high in IIA and IIIA. Septum presence in the maxillary sinus was observed in IIA, IIC, IIIA, IIIB, and IIIC of Hellman's dental age. Also, bony bridges were observed in IC, IIA, IIC, IIIA, IIIB, and IIIC of Hellman's dental age. PMID:20882766

Naitoh, Munetaka; Suenaga, Yutaka; Gotoh, Kenichi; Ito, Masaki; Kondo, Shintaro; Ariji, Eiichiro

2010-08-01

127

Observation of maxillary sinus septa and bony bridges using dry skulls between Hellman's dental age of IA and IIIC.  

UK PubMed Central (United Kingdom)

Maxillary sinus septa and bony bridges were observed using dry skulls in childhood, classified based on Hellman's dental age, to clarify maxillary sinus septum formation. Eighty-eight maxillary sinuses of 44 dry skulls and a cone-beam computed tomography (CBCT) unit were used. The locations of the septum, defined as a pointed bony structure originating from the inferior wall, and bony bridge, defined as a bony structure between the maxillary sinus wall and dental germ, were antero-posteriorly recorded, and the superoinferior distance, distance from the bony palate, and angle to the median palatine suture were measured. The rate of septum presence in the maxillary sinus was high (41.7%) in IIIC, and the septa were located in the deciduous molars, premolars, and molars. Also, all bony bridges were related to the median maxillary sinus wall, and the rate of the maxillary sinus showing a bony bridge was high in IIA and IIIA. Septum presence in the maxillary sinus was observed in IIA, IIC, IIIA, IIIB, and IIIC of Hellman's dental age. Also, bony bridges were observed in IC, IIA, IIC, IIIA, IIIB, and IIIC of Hellman's dental age.

Naitoh M; Suenaga Y; Gotoh K; Ito M; Kondo S; Ariji E

2010-08-01

128

Desmoplastic fibroma: report of rare lesion in unusual craniofacial location.  

Science.gov (United States)

Desmoplastic fibroma (DF) is a benign but aggressive intraosseous tumor. These lesions are categorized as central tumors of bone. They are composed of small fibroblasts in a setting of abundant extracellular material, which is rich in collagen. DF represents fewer than 0.1% of all bony tumors. They can be found in any part of the skeleton. Based upon on our literature review, we believe this is the second reported case of desmoplastic fibroma occurring in the zygoma area. PMID:23767400

Jamali, Majid

2013-04-01

129

Desmoplastic fibroma: report of rare lesion in unusual craniofacial location.  

UK PubMed Central (United Kingdom)

Desmoplastic fibroma (DF) is a benign but aggressive intraosseous tumor. These lesions are categorized as central tumors of bone. They are composed of small fibroblasts in a setting of abundant extracellular material, which is rich in collagen. DF represents fewer than 0.1% of all bony tumors. They can be found in any part of the skeleton. Based upon on our literature review, we believe this is the second reported case of desmoplastic fibroma occurring in the zygoma area.

Jamali M

2013-04-01

130

The anatomy of non-carious cervical lesions.  

Science.gov (United States)

OBJECTIVE: The term "non-carious cervical lesion" (NCCL) describes a dental hard tissue defect of unknown origin. Two very distinct variations are known: wedge-shaped and saucer-shaped lesions. Reasons for occurrence of two forms might include different contributing factors. METHODS: Forty-two teeth, 19 wedge-shaped and 23 saucer-shaped lesions, were analysed by light and confocal laser scanning microscopy (CLSM) to investigate presence of calculus and organic matter, surface structure of the lesion, borders of the lesion, and potential fractures in the dental hard tissues. RESULTS: One hundred percent of the wedge-shaped teeth showed evidence of additional abrasion (incisal/occlusal surface) but only 70 % of the saucer-shaped teeth. In most teeth, the edge was rounded. Tiny grooves parallel to the cemento-enamel junction (CEJ) were present in 11 % of the wedge-shaped and in 39 % of the saucer-shaped lesions. Seventy-nine percent wedge-shaped and 52 % saucer-shaped lesions had some sort of apposition. Eighty-eight percent of all teeth had dead tracts, 62 % of which were located directly next to the defect (in the lesion). In 48 %, sclerotic dentin was present right next to the defect (in the lesion). Tertiary dentin was visible in 60 %. Not a single fracture was detected. CONCLUSION: Different characteristics associated with each type of cervical lesion support the theory of different aetiology or at least of differing contributions from different factors that participate in the development of NCCLs. CLINICAL RELEVANCE: Only knowledge of the correct aetiology of NCCLs will allow the best treatment and prevention for such lesions. PMID:23494453

Walter, C; Kress, E; Götz, H; Taylor, K; Willershausen, I; Zampelis, A

2013-03-15

131

Autogenous platelet-rich plasma in combination with bovine-derived hydroxyapatite xenograft for treatment of a cystic lesion of the jaw.  

Science.gov (United States)

In the last 5 years, many studies about autogenous platelet-rich plasma have been undertaken pointing out its regenerative and reparative properties on tissues. The features of this product are an attribute of platelet cells, which, after cellular interactions, release growth factors. These molecules promote tissue healing and also induce cellular regeneration. Bone is a dynamic tissue subject to balanced processes of bony formation and reabsorption; autologous platelet gel or concentrate (PRP) can be used alone or in association with bony graft for the treatment of bony defect, cystic lesions, alveolar bone defects, and periodontal pockets. Its application fields are oral and maxillofacial surgery, plastic surgery, and general surgery, and it can be applied particularly in patients with coagulation diseases. In our experience, a giant cystic lesion of the jaw was treated with PRP and granules of bovine-derived hydroxyapatite xenograft to enhance bony regeneration and promote tissue healing. PMID:16327543

Belli, Evaristo; Longo, Benedetto; Balestra, Filippo Marini

2005-11-01

132

CT-diagnosis of optic nerve lesions. Differential diagnostic criteria  

Energy Technology Data Exchange (ETDEWEB)

Computed tomograms of 166 optic nerve lesions were analyzed: 97 were mainly orbital and 69 mainly intracranial. The criteria were clinical course, size, density and delineation of the optic nerve shadow, orbital and cerebral soft tissue abnormalities, and bony changes in the optic canal. Characteristic CT features are described of individual disease entities such as optic gliomas, optic nerve sheath meningiomas, neoplastic and inflammatory infiltrations. The differential diagnostic importance of individual CT criteria is evaluated and discussed. Simultaneous visualization of orbital and intracranial soft tissue changes as well as bony changes in the optic canal allow the location and identification of the majority of optic nerve lesions based on the criteria mentioned above, and optic nerve tumors can be differentiated. In 9 patients with optic neuritis due to clinically proven encephalitis and in 17 patients with total optic atrophy, no changes in the size of the optic nerve could be found. CT evaluation of the intraorbital portion of the optic nerve requires special examination techniques. Oblique computer reformations through the optic canal provide excellent visualization of bony changes in the optic canal. The exclusion of intracranial causes of optic nerve lesions requires intravenous injection of contrast material.

Unsoeld, R.

1982-01-01

133

Preliminary evaluation of an MRI-based technique for displaying and quantifying bony deformities in cam-type femoroacetabular impingement.  

Science.gov (United States)

PURPOSE   : Characterizing aspheric deformities of the femoral head-neck junction in cam-type femoroacetabular impingement (FAI) requires representing the location, size, or extent of the bony lesion. The objectives of this work are to (1) assess the feasibility of creating 3D models of cam deformities from MRI sets, (2) present a standardized 2D visualization of the lesion, and (3) present and evaluate the potential utility of summary metrics in distinguishing between FAI patients and control subjects. METHODS: Using MRIs from five subjects with diagnosed cam-type FAI and four healthy subjects, we developed a technique based on subtracting an estimated normal surface from each subject's actual bone surface in order to generate a subject-specific 2D "diagnosis graph" that characterized the femoral deformity. The models from three control subjects were combined to create the baseline model. RESULTS: The RMS fitting error between the surface models of individual control subjects and their corresponding baseline models was 1.05 mm across the head and the head-to-neck transition region. In the anterosuperior region of the 2D diagnosis graphs, the mean height of the detected cam deformities relative to the estimated baseline normal shape was 17.9 % of the head radius for the five FAI subjects (95 % CI 8.5-27.3 %) and 7.0 % (95 % CI 2.9-11.1 %) for the four control subjects. A binary logistic regression analysis indicated that an h/r ratio larger than a threshold of [Formula: see text] = 10.7 % (equivalent to approximately 2.3 mm in height) yielded the best discrimination between cam-type FAI subjects and normal subjects. CONCLUSIONS: Our 2D diagnosis graph qualitatively enabled the cam-type lesions in four of our five diagnosed patients to be clearly visualized on MRI-derived models. We believe this visualization tool may be helpful in better characterizing cam-type lesions for diagnosis and for developing more precise plans for surgical treatment. PMID:23549935

Kang, Xiumei; Zhang, Honglin; Garbuz, Donald; Wilson, David R; Hodgson, Antony J

2013-04-01

134

Preliminary evaluation of an MRI-based technique for displaying and quantifying bony deformities in cam-type femoroacetabular impingement.  

UK PubMed Central (United Kingdom)

PURPOSE   : Characterizing aspheric deformities of the femoral head-neck junction in cam-type femoroacetabular impingement (FAI) requires representing the location, size, or extent of the bony lesion. The objectives of this work are to (1) assess the feasibility of creating 3D models of cam deformities from MRI sets, (2) present a standardized 2D visualization of the lesion, and (3) present and evaluate the potential utility of summary metrics in distinguishing between FAI patients and control subjects. METHODS: Using MRIs from five subjects with diagnosed cam-type FAI and four healthy subjects, we developed a technique based on subtracting an estimated normal surface from each subject's actual bone surface in order to generate a subject-specific 2D "diagnosis graph" that characterized the femoral deformity. The models from three control subjects were combined to create the baseline model. RESULTS: The RMS fitting error between the surface models of individual control subjects and their corresponding baseline models was 1.05 mm across the head and the head-to-neck transition region. In the anterosuperior region of the 2D diagnosis graphs, the mean height of the detected cam deformities relative to the estimated baseline normal shape was 17.9 % of the head radius for the five FAI subjects (95 % CI 8.5-27.3 %) and 7.0 % (95 % CI 2.9-11.1 %) for the four control subjects. A binary logistic regression analysis indicated that an h/r ratio larger than a threshold of [Formula: see text] = 10.7 % (equivalent to approximately 2.3 mm in height) yielded the best discrimination between cam-type FAI subjects and normal subjects. CONCLUSIONS: Our 2D diagnosis graph qualitatively enabled the cam-type lesions in four of our five diagnosed patients to be clearly visualized on MRI-derived models. We believe this visualization tool may be helpful in better characterizing cam-type lesions for diagnosis and for developing more precise plans for surgical treatment.

Kang X; Zhang H; Garbuz D; Wilson DR; Hodgson AJ

2013-04-01

135

Medial depression with bony dehiscence of lamina papyracea as an anatomic variation: CT evaluation  

International Nuclear Information System (INIS)

[en] To evaluate the incidence and CT findings of the medial depression and bony dehiscence of lamina papyracea as an anatomic variation. 1472 PNS CTs of the patients with symptoms of chronic sinusitis were retrospectively evaluated. The total incidence of depressed lamina papyracea as an anatomic variation was 3.5%(52/1472) on PNS CT. There was a statistically significant correlation between the increasing age and the incidence of depressed lamina papyracea. Depression of lamina papyracea anterior to the basal lamella were more common than those of the posterior depression. Associated findings were herniation of adjacent fatty tissue in all cases and the medial bowing and hypertrophied configuration of the medial rectus muscle without significant herniation in 19 cases(34%). Nontraumatic, asymptomatic depression with bony dehiscence of lamina papyracea as an anatomic variation is not uncommon with the incidence of 3.5%. Recognition of its existence and degree may be helpful in avoiding various ocular complication during ethmoid surgery

1994-01-01

136

Modified pull-out wire suture technique for the treatment of chronic bony mallet finger.  

Science.gov (United States)

Twenty-three patients with a chronic bony mallet finger deformity (more than 3 months after the injury) and fracture fragment involving more than one-third of the articular surface underwent surgical treatment. The fracture fragment was fixed, and the mallet finger deformity was corrected in all patients using a modified pull-out wire (wire passed through the dorsal fragment directly) with a transarticular Kirschner wire fixation technique. Active motion of the proximal interphalangeal and metacarpophalangeal joints was not restricted. According to Crawford's evaluation criteria, there were 17 excellent, 4 good, and 2 fair results. Four patients showed radiologic signs of mild degenerative changes, which did not limit their daily activities. The modified pull-out wire suture with the transarticular Kirschner wire fixation technique provides an alternative and acceptable treatment modality for the treatment of chronic bony mallet finger deformities with or without subluxation of the distal phalanx. PMID:20841999

Lee, Sang Ki; Kim, Hwan Jeong; Lee, Kwang Won; Kim, Kap Jung; Choy, Won Sik

2010-11-01

137

Type IIb bony mallet finger: is anatomical reduction of the fracture necessary?  

UK PubMed Central (United Kingdom)

One-third of all mallet fingers are associated with a fracture. Many different management strategies have been described. Some authors recommend nonsurgical management for all mallet fractures. In contrast, others suggest mandatory open reduction and internal fixation for bony mallet injuries with a large displaced dorsal fragment and associated distal interphalangeal (DIP) joint subluxation. We retrospectively studied 3 cases of a mallet fracture with a large displaced dorsal fragment and subsequent DIP joint subluxation managed with closed reduction using only percutaneous pinning of the DIP joint. All 3 patients had satisfactory pain-free and functional clinical outcomes at their particular follow-up (4, 6, or 19 months). Closed reduction and internal fixation of the subluxated joint using only Kirschner wires produced satisfactory outcomes for the 3 type IIb bony mallet fingers. Anatomical reduction of the fracture may be unnecessary in patients such as those in our case series. One aim of this pilot study is to justify larger, prospective studies.

Neuhaus V; Thomas MA; Mudgal CS

2013-05-01

138

Modified pull-out wire suture technique for the treatment of chronic bony mallet finger.  

UK PubMed Central (United Kingdom)

Twenty-three patients with a chronic bony mallet finger deformity (more than 3 months after the injury) and fracture fragment involving more than one-third of the articular surface underwent surgical treatment. The fracture fragment was fixed, and the mallet finger deformity was corrected in all patients using a modified pull-out wire (wire passed through the dorsal fragment directly) with a transarticular Kirschner wire fixation technique. Active motion of the proximal interphalangeal and metacarpophalangeal joints was not restricted. According to Crawford's evaluation criteria, there were 17 excellent, 4 good, and 2 fair results. Four patients showed radiologic signs of mild degenerative changes, which did not limit their daily activities. The modified pull-out wire suture with the transarticular Kirschner wire fixation technique provides an alternative and acceptable treatment modality for the treatment of chronic bony mallet finger deformities with or without subluxation of the distal phalanx.

Lee SK; Kim HJ; Lee KW; Kim KJ; Choy WS

2010-11-01

139

Complete debridement for treatment of thoracolumbar spinal tuberculosis: a clinical curative effect observation.  

UK PubMed Central (United Kingdom)

CONCLUSIONS: Sclerotic bone, multiple cavities, and bony bridges are foci in spinal tuberculosis. Clearing tuberculous foci, sclerotic bone, multiple cavities, and bony bridges to increase the curative effect is an effective treatment method.

Jin W; Wang Q; Wang Z; Geng G

2013-10-01

140

Ulnar collateral ligament reconstruction with gracilis tendon in athletes with intraligamentous bony excision: technique and results.  

UK PubMed Central (United Kingdom)

BACKGROUND: Ulnar collateral ligament (UCL) reconstruction is frequently performed in throwing athletes, but outcomes of UCL reconstruction requiring excision of bone, either within the substance of or replacing the UCL, have not been studied. HYPOTHESIS: Clinical outcome for throwing athletes after UCL reconstruction with gracilis tendon will be less favorable for patients requiring concurrent excision of bone from within the substance of the UCL than for patients with no bone excision within, or replacing, the ligamentous anatomy. STUDY DESIGN: Cohort Study; Level of evidence, 3. METHODS: One hundred twenty pitchers of competitive levels between high school and major league who underwent UCL reconstruction using contralateral gracilis autografts completed a phone survey, and their medical charts were reviewed. Follow-up was a minimum of 2 years. Among the 120 patients, 42 (35%) had bone within, or replacing, the substance of the native UCL (bony group), and 78 (65%) had no bony abnormalities (nonbony group). The latter group of 78 underwent UCL reconstruction using gracilis tendon graft due to the absence of a palmaris longus tendon. Clinical outcomes were compared between the 2 study groups using t tests and ?2 analyses. RESULTS: There were no statistical differences regarding time to return to throwing, time to return to competition, postoperative complications, or need for additional surgeries. The percentage of patients who returned to the same or higher level was higher in the nonbony group (91%) than in the bony group (81%), but this trend was not statistically significant (P = .083), likely due to a relatively small sample size. Changes in self-reported pitch control were different (P = .029) between the 2 groups, with a greater percentage of pitchers experiencing decreased control in the bony group. CONCLUSION: The presence of bone concomitant with UCL damage can lead to pitch control problems after UCL reconstruction and may also decrease the chance of return to play.

Dugas JR; Bilotta J; Watts CD; Crum JA; Fleisig GS; McMichael CS; Cain EL Jr; Andrews JR

2012-07-01

 
 
 
 
141

Subacromial bony erosion: a rare presentation of pigmented villonodular synovitis of the shoulder.  

Science.gov (United States)

Pigmented villonodular synovitis (PVNS) rarely affects the shoulder. We describe two cases of PVNS arising from the shoulder joint, which caused rotator cuff tears and sub-acromial bony erosion, and which were treated arthroscopically. Sub-acromial erosion is frequently associated with various glenohumeral joint disorders, but it has not been reported in association with PVNS. We believe PVNS should also be considered in the differential diagnosis of patients who present with sub-acromial erosion. PMID:19252895

Ji, Jong-Hun; Shafi, Mohamed; Park, Sang-Eun; Kim, Weon-Yoo

2009-02-28

142

Obraz kliniczny i mikroskopowy b?ony ?luzowej jamy ustnej u pacjentów z rakiem jelita grubego  

Directory of Open Access Journals (Sweden)

Full Text Available Wprowadzenie: Sta?y wzrost zapadalno?ci na raka jelita grubego, przy braku istotnej poprawy leczenia, powoduje intensyfikacj? poszukiwa? swoistych markerów i objawów umo?liwiaj?cych wykrycie wczesnych, niezaawansowanych zmian nowotworowych. Cel pracy: Ocena zmian makroskopowych i cytologicznych b?ony ?luzowej jamy ustnej u chorych leczonych z powodu raka jelita grubego. Materia? i metody: Badania przeprowadzono u 60 chorych (32 kobiet i 28 m??czyzn, ?rednia wieku 67,8±14,15 roku), planowo leczonych operacyjnie z powodu raka jelita grubego i odbytnicy. Po przeprowadzonym badaniu klinicznym jamy ustnej, u wszystkich chorych wykonywano biopsje szczoteczkowe b?ony ?luzowej, w celu dokonania oceny cytologicznej. Uzyskane wyniki odniesiono do grupy kontrolnej 60 innych chorych, leczonych operacyjnie z powodu ?agodnych schorze?. Wyniki: Stan miejscowy b?ony ?luzowej jamy ustnej pacjentów obu grup by? podobny, u ponad po?owy badanych okre?lony jako prawid?owy. Najcz??ciej obserwowane zmiany patologiczne dotyczy?y j?zyka (70% chorych). W obrazie cytologicznym u prawie 70% pacjentów dominowa?a klasa II Papanicolaou - odczynowa. Odsetkowy rozk?ad poszczególnych zmian by? podobny, a stwierdzone ró?nice nie by?y istotne statystycznie (p >0,01). Wnioski: 1. Nie stwierdzono ?adnych makroskopowych ani cytologicznych zmian w obr?bie b?ony ?luzowej jamy ustnej, które wyró?nia?yby chorych na raka jelita grubego. 2. Najcz??ciej wyst?puj?ce u chorych zmiany makroskopowe w obr?bie jamy ustnej nie wykazuj? istotnej korelacji ze wspó?istnieniem raka jelita grubego.

Bo?ena K?dra, Ma?gorzata Barwijuk-Macha?a, Monika Chomczyk, Wanda Stokowska, Bogus?aw K?dra, Ma?gorzata Pietruska

2011-01-01

143

Bony pelvis dimensions in women with and without stress urinary incontinence.  

UK PubMed Central (United Kingdom)

AIMS: To test the null hypothesis that bony pelvis dimensions are similar in women with and without stress urinary incontinence (SUI), both in the postpartum and midlife periods. METHODS: Secondary analyses were performed of two case-control studies comparing women with SUI to asymptomatic controls. One study examined primiparas in the first 9-12 months postpartum; the other study involved middle-aged women. SUI was confirmed by full-bladder stress test. All subjects underwent pelvic magnetic resonance imaging. The interspinous and intertuberous diameters, subpubic angle, and sacrococcygeal joint-to-the inferior pubic point distance were measured from the images independently by two authors. RESULTS: In the young cohorts, we compared primiparas with de novo postpartum SUI to both continent primiparas and nulliparas. Postpartum SUI is associated with a wider subpubic angle. There is also a trend towards wider interspinous and intertuberous diameters in the stress-incontinent primiparas as compared to the continent cohorts, although this did not reach statistical significance with our sample sizes. By contrast, no significant differences in bony pelvis dimensions were identified when comparing middle-aged women with SUI and their continent controls. CONCLUSIONS: Bony pelvis dimensions are different in women with SUI than in matched continent controls. However, these differences are only identified in young primiparas in the postpartum period, not in middle-aged women.

Berger MB; Doumouchtsis SK; DeLancey JO

2013-01-01

144

Genome-wide association study of degenerative bony changes of the temporomandibular joint.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To identify susceptibility genes underlying degenerative bony changes of the temporomandibular joint (TMJ). MATERIALS AND METHODS: Bony changes of the TMJ condylar head were diagnosed by examination of panoramic radiographs and/or magnetic resonance images and/or computed tomography images. We conducted a genome-wide association study (GWAS) of 146 cases with TMJ degeneration and 374 controls from East Asian populations using an Illumina HumanOmniExpress BeadChip. After rigorous quality-control filtering, approximately 550 000 single nucleotide polymorphisms (SNPs) were used for tests of associations with disease status. RESULTS: Forty-one SNPs at 22 independent loci showed association signals at P < 1 × 10(-4) . The SNP rs878962, which maps on an intron of TSPAN9 on chromosome 12, showed the strongest association (combined OR = 1.89, 95% confidence interval = 1.43-2.50, P = 8.1 × 10(-6) ). According to in silico predictions of the 41 SNPs, two intronic SNPs of APOL3 (rs80575) and MRC2 (rs2460300) may fall within regulatory elements and affect DNA-protein interactions. We could not replicate SNPs located on genes that have been reported to be associated with temporomandibular disorder or temporomandibular osteoarthritis in previous studies at P < 1 × 10(-4) . CONCLUSIONS: Our GWAS identified 22 independent loci showing suggestive association signals with degenerative bony changes of the TMJ. These loci provide good candidates for future follow-up studies.

Yamaguchi T; Nakaoka H; Yamamoto K; Fujikawa T; Kim YI; Yano K; Haga S; Katayama K; Shibusawa T; Park S; Maki K; Kimura R; Inoue I

2013-05-01

145

Management of tibial bony defect with metal block in primary total knee replacement arthroplasty.  

UK PubMed Central (United Kingdom)

PURPOSE: To analyze minimum 2-year clinical and radiological follow-up results of primary total knee replacement arthroplasty (TKRA) with metal block augmentation for tibial bony defect. MATERIALS AND METHODS: We analyzed 67 cases (52 patients) of primary TKRA with metal block augmentation for tibial bony defects from March 1999 and March 2008. Clinical results were evaluated using the Knee Society clinical rating system and the Western Ontario and McMaster University (WOMAC) score. Radiologic results were evaluated using the Knee Society roentgenographic evaluation system. RESULTS: The mean knee score and function score improved from 42.0 and 45.6 preoperatively to 94.5 and 85.4 postoperatively. At last follow-up, the mean WOMAC score was 16.8. The incidence of radiolucent lines was 10% (7 cases) during the follow-up period, but there was no case of progression. There were no statistically significant differences between the groups divided according to the block size (below 5 mm and over 8 mm) and between the stem and no-stem groups for all parameters. CONCLUSIONS: Primary TKRA with a metal block produced satisfactory results for the minimum 2-year follow-up and can be considered as a simple and effective method for the treatment of tibial bony defect in primary TKRA.

Baek SW; Kim CW; Choi CH

2013-03-01

146

Computed tomography and hypocycloid tomography in lesions of the nose, paranasal sinuses and nasopharynx  

Energy Technology Data Exchange (ETDEWEB)

In 31 patients with lesions mainly arising from the nose, paranasal sinuses and nasopharynx comparative evaluation of the results of CT and hypocycloid tomography indicated that CT generally gave a better representation of both the bony structures and the soft parts and alone has the capacity to evaluate intracranial extension. CT should first be performed in the transverse axial plane. If abnormalities in relation to horizontal bony structures are demonstrated, the examination should be supplemented by CT in the coronal plane or, if CT scanning in this plane is not possible, by conventional tomography. Enhancement after intravenous injection of contrast medium does not as a rule seem to add information of diagnostic importance.

Nehen, A.M.; Illum, P.; Ratjen, E.; Illum, F.; Elbroend, O. (Department of Neuroradiology, University Hospital of Aarhus, Aarhus, Denmark)

1981-01-01

147

[Lesions in lungs in patients with rheumatoid arthritis].  

Science.gov (United States)

The aim of this work was to study the prevalence and clinical features of affection of lungs and lower respiratory tract (LRT) in patients with rheumatoid arthritis (RA). A total of 104 non-smoking patients with RA and 100 ones without RA or chronic pulmonary diseases were examined. RA was associated with affection of all parts of the respiratory tract including proximal and distal bronchi, lung interstitium, and pleura. Bronchopulmonary disorders in RA patients had multilevel character suggesting continuous inflammation and sclerotization of anatomic respiratory structures. Lesions in lungs and LRT are shown to be of prognostic value (bronchiectasis, bronchiolitis, interstitial pneumonia), they frequently produce only weak clinical symptoms, and therefore need to be actively detected. Combination of functional tests and imaging techniques is of primary importance for diagnosis of respiratory problems in patients with RA. PMID:21105472

Sheianov, M V; Ternovo?, S K; Fominykh, E V; Zavrazhina, I N; Makolkin, V I; Sulimov, V A

2010-01-01

148

[Lesions in lungs in patients with rheumatoid arthritis].  

UK PubMed Central (United Kingdom)

The aim of this work was to study the prevalence and clinical features of affection of lungs and lower respiratory tract (LRT) in patients with rheumatoid arthritis (RA). A total of 104 non-smoking patients with RA and 100 ones without RA or chronic pulmonary diseases were examined. RA was associated with affection of all parts of the respiratory tract including proximal and distal bronchi, lung interstitium, and pleura. Bronchopulmonary disorders in RA patients had multilevel character suggesting continuous inflammation and sclerotization of anatomic respiratory structures. Lesions in lungs and LRT are shown to be of prognostic value (bronchiectasis, bronchiolitis, interstitial pneumonia), they frequently produce only weak clinical symptoms, and therefore need to be actively detected. Combination of functional tests and imaging techniques is of primary importance for diagnosis of respiratory problems in patients with RA.

Sheianov MV; Ternovo? SK; Fominykh EV; Zavrazhina IN; Makolkin VI; Sulimov VA

2010-01-01

149

Surgical removal of a dermoid cyst from the bony part of the nasolacrimal duct in a Scottish highland cattle heifer.  

Science.gov (United States)

The ophthalmologic, radiologic and surgical findings of a 2-year-old Scottish Highland Cattle heifer with a dermoid cyst within the bony part of the nasolacrimal duct and the successful treatment are presented. PMID:19604343

Steinmetz, Andrea; Locher, Lena; Delling, Uta; Ionita, Jean-Claude; Ludewig, Eberhard; Oechtering, Gerhard; Wittek, Thomas

150

Computed tomographic features of the bony canal of the cochlear nerve in pediatric patients with unilateral sensorineural hearing loss  

International Nuclear Information System (INIS)

The aim of this study was to evaluate the diameters of the various bony canals of the inner ear in patients with sensorineural hearing loss (SNHL) and establish criteria for detecting hypoplasia of the bony canal of the cochlear nerve. Measurements obtained in 118 patients without inner ear malformations among 160 patients with unilateral SNHL were analyzed. The diameters of the internal auditory canal and the bony canals of the cochlear, vestibular, and facial nerves were measured on transverse or coronal computed tomographic images. Mean values (±standard deviation (SD)) were compared between the affected and unaffected ears, and statistical analysis was done. The diameter of the bony canal of the cochlear nerve was significantly smaller in affected ears than in unaffected ears (P

2008-01-01

151

A Diphenol Oxidase Gene Is Part of a Cluster of Genes Involved in Catecholamine Metabolism and Sclerotization in Drosophila. I. Identification of the Biochemical Defect in Dox-A2 [l(2)37Bf] Mutants  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Phenol oxidase, a complex enzyme, plays a major role in the processes of sclerotization and melanization of cuticle in insects. Several loci have been reported to affect levels of phenol oxidase activity, but to date only one structural locus has been identified [Dox-3F ( 2-53.1+)]. Recently isolate...

Pentz, Ellen Steward; Black, Bruce C.; Wright, Theodore R. F.

152

Clinical characteristics of patients with narrow bony cochlear nerve canal: is the bilateral case just a duplicate of the unilateral case?  

UK PubMed Central (United Kingdom)

OBJECTIVES/HYPOTHESIS: To evaluate whether there is a genetic contribution to the development of narrow bony cochlear nerve canal and analyze the differences between unilateral and bilateral narrow bony cochlear nerve canal. STUDY DESIGN: Retrospective review. METHODS: Patients diagnosed with unilateral (n=44) or bilateral (n=13) sensorineural hearing loss with narrow bony cochlear nerve canals from October 2004 to July 2011 were evaluated. The segregation ratio of hearing loss among siblings of probands was calculated. The differences in segregation ratio and other clinical characteristics were also compared. RESULTS: The segregation ratio of hearing loss in siblings of patients with unilateral narrow bony cochlear nerve canal was close to zero, whereas the ratio in siblings of patients with bilateral canals was 20%. Internal auditory canal narrowing was significantly more frequently combined in unilateral than bilateral narrow bony cochlear nerve canal cases. Cochlear nerve deficiency based on magnetic resonance imaging was found in 63.6% of bilateral narrow bony cochlear nerve canal cases. Milder hearing loss was exclusively detected in bilateral cases. CONCLUSIONS: Narrow bony cochlear nerve canal is not likely to have a simple Mendelian inheritance pattern, especially in unilateral cases. The contribution of a Mendelian genetic etiology to bilateral narrow bony cochlear nerve canals remains elusive. More frequent coexistence of internal auditory canal narrowing among unilateral narrow bony cochlear nerve canal cases suggests that bilateral narrow bony cochlear nerve canals are not just a duplicate of the unilateral narrow bony cochlear nerve canal.

Cho SW; Kang SI; Park SJ; Kim AR; Koo JW; Kim CS; Lee JH; Chang SO; Oh SH; Choi BY

2013-08-01

153

Effects of bone wax on rabbit cranial bone lesions.  

UK PubMed Central (United Kingdom)

The present study was designed to elucidate the reactions of cranial membranous bone to bone wax. In ten young rabbits, twenty parietal bone defects were created by drilling, the edges of which were partly extended using rongeur forceps to enable investigation of eventual thermal effects. Half of the marginal bone surrounding the lesions was covered by bone wax, the remainder serving as control. The animals were sacrificed 1 and 7 weeks after surgery, and block specimens prepared for light microscopy. Merely slight tissue reactions to the bone wax were discerned. Bony regeneration occurred mainly from the dura mater and the pericranium, but also from the bony rim. Reskeletalization was markedly impaired by the presence of bone wax. Heat generated by drilling caused reduced bone formation despite constant irrigation peroperatively. Clinical consequences are discussed.

Alberius P; Klinge B; Sjögren S

1987-04-01

154

The Tree of Life and a New Classification of Bony Fishes  

Science.gov (United States)

The tree of life of fishes is in a state of flux because we still lack a comprehensive phylogeny that includes all major groups. The situation is most critical for a large clade of spiny-finned fishes, traditionally referred to as percomorphs, whose uncertain relationships have plagued ichthyologists for over a century. Most of what we know about the higher-level relationships among fish lineages has been based on morphology, but rapid influx of molecular studies is changing many established systematic concepts. We report a comprehensive molecular phylogeny for bony fishes that includes representatives of all major lineages. DNA sequence data for 21 molecular markers (one mitochondrial and 20 nuclear genes) were collected for 1410 bony fish taxa, plus four tetrapod species and two chondrichthyan outgroups (total 1416 terminals). Bony fish diversity is represented by 1093 genera, 369 families, and all traditionally recognized orders. The maximum likelihood tree provides unprecedented resolution and high bootstrap support for most backbone nodes, defining for the first time a global phylogeny of fishes. The general structure of the tree is in agreement with expectations from previous morphological and molecular studies, but significant new clades arise. Most interestingly, the high degree of uncertainty among percomorphs is now resolved into nine well-supported supraordinal groups. The order Perciformes, considered by many a polyphyletic taxonomic waste basket, is defined for the first time as a monophyletic group in the global phylogeny. A new classification that reflects our phylogenetic hypothesis is proposed to facilitate communication about the newly found structure of the tree of life of fishes. Finally, the molecular phylogeny is calibrated using 60 fossil constraints to produce a comprehensive time tree. The new time-calibrated phylogeny will provide the basis for and stimulate new comparative studies to better understand the evolution of the amazing diversity of fishes.

Betancur-R., Ricardo; Broughton, Richard E.; Wiley, Edward O.; Carpenter, Kent; Lopez, J. Andres; Li, Chenhong; Holcroft, Nancy I.; Arcila, Dahiana; Sanciangco, Millicent; Cureton II, James C; Zhang, Feifei; Buser, Thaddaeus; Campbell, Matthew A.; Ballesteros, Jesus A; Roa-Varon, Adela; Willis, Stuart; Borden, W. Calvin; Rowley, Thaine; Reneau, Paulette C.; Hough, Daniel J.; Lu, Guoqing; Grande, Terry; Arratia, Gloria; Orti, Guillermo

2013-01-01

155

Influence of soft tissues on the proximal bony tibial slope measured with two-dimensional MRI.  

UK PubMed Central (United Kingdom)

PURPOSE: Despite increasing interest in the functional anatomy of the menisci, little information is available regarding the relationship between the tibial slope and the menisci. It was hypothesized that the meniscus would reduce the differences in slope between the medial and lateral compartments and would mitigate the effects of age and gender on the tibial slope. METHODS: MRI sagittal images from 101 patients were used in this study. The angle between a line tangent to the medial and lateral tibial bony slope and the proximal tibial anatomical axis was measured on sagittal MRI images (bony slope). The angle between the tangent line to the highest point of the anterior and posterior horn of the meniscus and the proximal tibial anatomical axis was also determined (soft tissue slope). The measurements were carried out twice by two observers. The influence of gender and age on these parameters was analysed. RESULTS: Repeated measures analysis of variance showed good inter- and intra-observer reliability for both bony and soft tissue slope (ICC (0.87-0.93) and (0.91-0.97) for inter- and intra-observer reliability, respectively). In both compartments, the soft tissue significantly reduced the tibial slope towards the horizontal plane. In addition, the soft tissue slope was significantly more horizontal in the lateral compartment compared to the medial compartment (p < 0.01). These differences were not influenced by age or gender. CONCLUSION: The menisci of the knee generate a more horizontal tibial slope when measured on MRI. The soft tissue slope is more horizontal in the lateral compartment of the knee compared to the medial compartment. LEVEL OF EVIDENCE: Diagnostic, Level III.

Lustig S; Scholes CJ; Leo SP; Coolican M; Parker DA

2013-02-01

156

The tree of life and a new classification of bony fishes.  

UK PubMed Central (United Kingdom)

The tree of life of fishes is in a state of flux because we still lack a comprehensive phylogeny that includes all major groups. The situation is most critical for a large clade of spiny-finned fishes, traditionally referred to as percomorphs, whose uncertain relationships have plagued ichthyologists for over a century. Most of what we know about the higher-level relationships among fish lineages has been based on morphology, but rapid influx of molecular studies is changing many established systematic concepts. We report a comprehensive molecular phylogeny for bony fishes that includes representatives of all major lineages. DNA sequence data for 21 molecular markers (one mitochondrial and 20 nuclear genes) were collected for 1410 bony fish taxa, plus four tetrapod species and two chondrichthyan outgroups (total 1416 terminals). Bony fish diversity is represented by 1093 genera, 369 families, and all traditionally recognized orders. The maximum likelihood tree provides unprecedented resolution and high bootstrap support for most backbone nodes, defining for the first time a global phylogeny of fishes. The general structure of the tree is in agreement with expectations from previous morphological and molecular studies, but significant new clades arise. Most interestingly, the high degree of uncertainty among percomorphs is now resolved into nine well-supported supraordinal groups. The order Perciformes, considered by many a polyphyletic taxonomic waste basket, is defined for the first time as a monophyletic group in the global phylogeny. A new classification that reflects our phylogenetic hypothesis is proposed to facilitate communication about the newly found structure of the tree of life of fishes. Finally, the molecular phylogeny is calibrated using 60 fossil constraints to produce a comprehensive time tree. The new time-calibrated phylogeny will provide the basis for and stimulate new comparative studies to better understand the evolution of the amazing diversity of fishes.

Betancur-R R; Broughton RE; Wiley EO; Carpenter K; López JA; Li C; Holcroft NI; Arcila D; Sanciangco M; Cureton Ii JC; Zhang F; Buser T; Campbell MA; Ballesteros JA; Roa-Varon A; Willis S; Borden WC; Rowley T; Reneau PC; Hough DJ; Lu G; Grande T; Arratia G; Ortí G

2013-01-01

157

Modified extension-block K-wire fixation technique for the treatment of bony mallet finger.  

Science.gov (United States)

This article describes the treatment of a bony mallet finger deformity using 2 extension-block Kirschner wires (K-wires) with a transarticular K-wire fixation technique for precise alignment of the terminal extensor tendon-bone relationship and effective immobilization of the distal interphalangeal joint. Twenty-nine patients (33 fingers) with a bony mallet finger deformity and fracture fragment involving more than one-third of the articular surface were treated surgically. The fracture fragment was fixed and the mallet finger deformity was corrected in all patients using modified extension-block K-wires (2 dorsal extension-block pins) with a transarticular K-wire (volar side pin) fixation technique. Active motion of the proximal interphalangeal and metacarpophalangeal joints was not restricted. The wires are removed in the clinic 6 weeks postoperatively when the bridging trabeculae were observed in the radiographs, and immobilization in a stock splint was continued for an additional 2 weeks. According to Crawford's evaluation criteria, there were 24 (73%) excellent, 7 (21%) good, and 2 (6%) fair results. Three patients showed radiological signs of mild degenerative changes, which did not limit their daily activities. Nail ridging occurred in 3 cases (9%), which disappeared after an average of 6 months with normal growth, and mild scarring at the dorsal pin site occurred in 2 cases (6%). Modified extension-block K-wires with a transarticular K-wire fixation technique is an acceptable alternative treatment modality for the management of bony mallet finger deformities with or without subluxation of the distal phalanx. PMID:20954665

Lee, Sang Ki; Kim, Kap Jung; Yang, Dae Suk; Moon, Kyung Ho; Choy, Won Sik

2010-10-11

158

Modified extension-block K-wire fixation technique for the treatment of bony mallet finger.  

UK PubMed Central (United Kingdom)

This article describes the treatment of a bony mallet finger deformity using 2 extension-block Kirschner wires (K-wires) with a transarticular K-wire fixation technique for precise alignment of the terminal extensor tendon-bone relationship and effective immobilization of the distal interphalangeal joint. Twenty-nine patients (33 fingers) with a bony mallet finger deformity and fracture fragment involving more than one-third of the articular surface were treated surgically. The fracture fragment was fixed and the mallet finger deformity was corrected in all patients using modified extension-block K-wires (2 dorsal extension-block pins) with a transarticular K-wire (volar side pin) fixation technique. Active motion of the proximal interphalangeal and metacarpophalangeal joints was not restricted. The wires are removed in the clinic 6 weeks postoperatively when the bridging trabeculae were observed in the radiographs, and immobilization in a stock splint was continued for an additional 2 weeks. According to Crawford's evaluation criteria, there were 24 (73%) excellent, 7 (21%) good, and 2 (6%) fair results. Three patients showed radiological signs of mild degenerative changes, which did not limit their daily activities. Nail ridging occurred in 3 cases (9%), which disappeared after an average of 6 months with normal growth, and mild scarring at the dorsal pin site occurred in 2 cases (6%). Modified extension-block K-wires with a transarticular K-wire fixation technique is an acceptable alternative treatment modality for the management of bony mallet finger deformities with or without subluxation of the distal phalanx.

Lee SK; Kim KJ; Yang DS; Moon KH; Choy WS

2010-10-01

159

Torque measurements of the mechanical load capacity of thin bony structures of the visceral cranium.  

UK PubMed Central (United Kingdom)

The stability of self-tapping screws of the Luhr (1979)-mini-plate system in thin facial bones was assessed. The maximal possible torque which can be applied to the screws before they strip the thread in the bone was measured. This end point was called the penetration torque. Only the central section of the maxillary sinus wall was unsuitable for anchorage of the screw and plate. The other sections of the osseous middle and lateral parts of the face, of the glabella and of the root of the nose have sufficient strength for bony segments to be anchored using plates.

Drommer RB

1986-06-01

160

Torque measurements of the mechanical load capacity of thin bony structures of the visceral cranium.  

Science.gov (United States)

The stability of self-tapping screws of the Luhr (1979)-mini-plate system in thin facial bones was assessed. The maximal possible torque which can be applied to the screws before they strip the thread in the bone was measured. This end point was called the penetration torque. Only the central section of the maxillary sinus wall was unsuitable for anchorage of the screw and plate. The other sections of the osseous middle and lateral parts of the face, of the glabella and of the root of the nose have sufficient strength for bony segments to be anchored using plates. PMID:3459790

Drommer, R B

1986-06-01

 
 
 
 
161

An extrarenal rhabdoid tumor of the cervical spine with bony involvement  

Energy Technology Data Exchange (ETDEWEB)

A case of a histologically proven rhabdoid tumor of the cervical spine in a 19-year-old Caucasian male is presented. Primary extrarenal rhabdoid tumors are very rare. When the central nervous system is involved, the tumor usually is located in the brain. Only three cases of primary spinal rhabdoid tumor have been reported. This case is the first reported extradural rhabdoid tumor of the spinal canal and the first case of a rhabdoid tumor located in the spinal canal with bony involvement. (orig.)

Robbens, C.; Wilms, G. [U.Z. Gasthuisberg, Department of Radiology, Leuven (Belgium); Vanwyck, R. [Salvator Hospital, Department of Radiology, Hasselt (Belgium); Sciot, R. [U.Z. Gasthuisberg, Department of Pathology, Leuven (Belgium); Debiec-Rychter, M. [U.Z. Gasthuisberg, Human Genetic Centre, Leuven (Belgium)

2007-04-15

162

Traumatic anterior hip dislocation associated with anterior and inferior iliac spines avulsions and a capsular–labral lesion  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A 16-year-old man had a traumatic accident during motor-cross racing and sustained an anterior hip dislocation with fracture of anterior superior and anterior inferior iliac spines. The hip was emergently reduced and further imaging was obtained to evaluate the lesion and bony fragments. Computed to...

Reggiori, A.; Brugo, G.

163

The relationship of transverse sinus stenosis to bony groove dimensions provides an insight into the aetiology of idiopathic intracranial hypertension  

Energy Technology Data Exchange (ETDEWEB)

Transverse sinus tapered narrowings are frequently identified in patients with idiopathic intracranial hypertension (IIH); however, it remains unclear whether they are primary stenoses or whether they occur secondary to raised cerebrospinal fluid pressure. Computed tomographic venography demonstrates both the morphology of the venous system and the adjacent bony grooves so it may provide an insight into the aetiology of these transverse sinus stenoses. Tapered transverse sinus narrowings (>50%) were studied in 19 patients without IIH and 14 patients with IIH. Computed tomography vascular studies were reviewed and the dimensions of the venous sinuses and bony grooves at the sites of maximum and minimum transverse sinus area dimensions were recorded. There was demonstrated to be a strong correlation of bony groove height with venous sinus height at the largest portions of the transverse sinus in both IIH patients and non-IIH subjects as well as at the transverse sinus narrowing in non-IIH subjects. There was a discordant relationship between bony groove height and venous sinus height at the site of transverse sinus stenoses in IIH patients. In 5/23 IIH transverse sinus stenoses, the bony groove height was proportionate to that seen in non-IIH subjects. There were a further 8/23 cases where the small or absent sinus was associated with an absent bony groove. Transverse sinus tapered narrowings in subjects without IIH and in the majority of patients with IIH were associated with proportionately small or absent grooves, and these are postulated to be primary or fixed. Some patients with IIH demonstrate tapered transverse sinus stenoses with disproportionately large bony grooves, suggesting a secondary or acquired narrowing. This implies a varied aetiology for the transverse sinus stenoses of IIH. (orig.)

Connor, S.E.J.; Stewart, V.R.; O' Flynn, E.A.M. [King' s College Hospital, Neuroradiology Department, Ruskin Wing, London (United Kingdom); Siddiqui, M.A. [Southern General Hospital, Institute of Neurological Sciences, Glasgow (United Kingdom)

2008-12-15

164

The relationship of transverse sinus stenosis to bony groove dimensions provides an insight into the aetiology of idiopathic intracranial hypertension  

International Nuclear Information System (INIS)

Transverse sinus tapered narrowings are frequently identified in patients with idiopathic intracranial hypertension (IIH); however, it remains unclear whether they are primary stenoses or whether they occur secondary to raised cerebrospinal fluid pressure. Computed tomographic venography demonstrates both the morphology of the venous system and the adjacent bony grooves so it may provide an insight into the aetiology of these transverse sinus stenoses. Tapered transverse sinus narrowings (>50%) were studied in 19 patients without IIH and 14 patients with IIH. Computed tomography vascular studies were reviewed and the dimensions of the venous sinuses and bony grooves at the sites of maximum and minimum transverse sinus area dimensions were recorded. There was demonstrated to be a strong correlation of bony groove height with venous sinus height at the largest portions of the transverse sinus in both IIH patients and non-IIH subjects as well as at the transverse sinus narrowing in non-IIH subjects. There was a discordant relationship between bony groove height and venous sinus height at the site of transverse sinus stenoses in IIH patients. In 5/23 IIH transverse sinus stenoses, the bony groove height was proportionate to that seen in non-IIH subjects. There were a further 8/23 cases where the small or absent sinus was associated with an absent bony groove. Transverse sinus tapered narrowings in subjects without IIH and in the majority of patients with IIH were associated with proportionately small or absent grooves, and these are postulated to be primary or fixed. Some patients with IIH demonstrate tapered transverse sinus stenoses with disproportionately large bony grooves, suggesting a secondary or acquired narrowing. This implies a varied aetiology for the transverse sinus stenoses of IIH. (orig.)

2008-01-01

165

PET/MR imaging of bone lesions - implications for PET quantification from imperfect attenuation correction  

International Nuclear Information System (INIS)

Accurate attenuation correction (AC) is essential for quantitative analysis of PET tracer distribution. In MR, the lack of cortical bone signal makes bone segmentation difficult and may require implementation of special sequences. The purpose of this study was to evaluate the need for accurate bone segmentation in MR-based AC for whole-body PET/MR imaging. In 22 patients undergoing sequential PET/CT and 3-T MR imaging, modified CT AC maps were produced by replacing pixels with values of >100 HU, representing mostly bone structures, by pixels with a constant value of 36 HU corresponding to soft tissue, thereby simulating current MR-derived AC maps. A total of 141 FDG-positive osseous lesions and 50 soft-tissue lesions adjacent to bones were evaluated. The mean standardized uptake value (SUVmean) was measured in each lesion in PET images reconstructed once using the standard AC maps and once using the modified AC maps. Subsequently, the errors in lesion tracer uptake for the modified PET images were calculated using the standard PET image as a reference. Substitution of bone by soft tissue values in AC maps resulted in an underestimation of tracer uptake in osseous and soft tissue lesions adjacent to bones of 11.2 ± 5.4 % (range 1.5-30.8 %) and 3.2 ± 1.7 % (range 0.2-4 %), respectively. Analysis of the spine and pelvic osseous lesions revealed a substantial dependence of the error on lesion composition. For predominantly sclerotic spine lesions, the mean underestimation was 15.9 ± 3.4 % (range 9.9-23.5 %) and for osteolytic spine lesions, 7.2 ± 1.7 % (range 4.9-9.3 %), respectively. CT data simulating treating bone as soft tissue as is currently done in MR maps for PET AC leads to a substantial underestimation of tracer uptake in bone lesions and depends on lesion composition, the largest error being seen in sclerotic lesions. Therefore, depiction of cortical bone and other calcified areas in MR AC maps is necessary for accurate quantification of tracer uptake values in PET/MR imaging. (orig.)

2012-01-01

166

PET/MR imaging of bone lesions - implications for PET quantification from imperfect attenuation correction  

Energy Technology Data Exchange (ETDEWEB)

Accurate attenuation correction (AC) is essential for quantitative analysis of PET tracer distribution. In MR, the lack of cortical bone signal makes bone segmentation difficult and may require implementation of special sequences. The purpose of this study was to evaluate the need for accurate bone segmentation in MR-based AC for whole-body PET/MR imaging. In 22 patients undergoing sequential PET/CT and 3-T MR imaging, modified CT AC maps were produced by replacing pixels with values of >100 HU, representing mostly bone structures, by pixels with a constant value of 36 HU corresponding to soft tissue, thereby simulating current MR-derived AC maps. A total of 141 FDG-positive osseous lesions and 50 soft-tissue lesions adjacent to bones were evaluated. The mean standardized uptake value (SUVmean) was measured in each lesion in PET images reconstructed once using the standard AC maps and once using the modified AC maps. Subsequently, the errors in lesion tracer uptake for the modified PET images were calculated using the standard PET image as a reference. Substitution of bone by soft tissue values in AC maps resulted in an underestimation of tracer uptake in osseous and soft tissue lesions adjacent to bones of 11.2 {+-} 5.4 % (range 1.5-30.8 %) and 3.2 {+-} 1.7 % (range 0.2-4 %), respectively. Analysis of the spine and pelvic osseous lesions revealed a substantial dependence of the error on lesion composition. For predominantly sclerotic spine lesions, the mean underestimation was 15.9 {+-} 3.4 % (range 9.9-23.5 %) and for osteolytic spine lesions, 7.2 {+-} 1.7 % (range 4.9-9.3 %), respectively. CT data simulating treating bone as soft tissue as is currently done in MR maps for PET AC leads to a substantial underestimation of tracer uptake in bone lesions and depends on lesion composition, the largest error being seen in sclerotic lesions. Therefore, depiction of cortical bone and other calcified areas in MR AC maps is necessary for accurate quantification of tracer uptake values in PET/MR imaging. (orig.)

Samarin, Andrei [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); University Hospital Zurich, Nuclear Medicine, Zurich (Switzerland); Burger, Cyrill; Crook, David W.; Burger, Irene A.; Schmid, Daniel T.; Schulthess, Gustav K. von; Kuhn, Felix P. [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); Wollenweber, Scott D. [GE Healthcare, Waukesha, WI (United States)

2012-07-15

167

Multi-locus phylogenetic analysis reveals the pattern and tempo of bony fish evolution.  

Science.gov (United States)

Over half of all vertebrates are "fishes", which exhibit enormous diversity in morphology, physiology, behavior, reproductive biology, and ecology. Investigation of fundamental areas of vertebrate biology depend critically on a robust phylogeny of fishes, yet evolutionary relationships among the major actinopterygian and sarcopterygian lineages have not been conclusively resolved. Although a consensus phylogeny of teleosts has been emerging recently, it has been based on analyses of various subsets of actinopterygian taxa, but not on a full sample of all bony fishes. Here we conducted a comprehensive phylogenetic study on a broad taxonomic sample of 61 actinopterygian and sarcopterygian lineages (with a chondrichthyan outgroup) using a molecular data set of 21 independent loci. These data yielded a resolved phylogenetic hypothesis for extant Osteichthyes, including 1) reciprocally monophyletic Sarcopterygii and Actinopterygii, as currently understood, with polypteriforms as the first diverging lineage within Actinopterygii; 2) a monophyletic group containing gars and bowfin (= Holostei) as sister group to teleosts; and 3) the earliest diverging lineage among teleosts being Elopomorpha, rather than Osteoglossomorpha. Relaxed-clock dating analysis employing a set of 24 newly applied fossil calibrations reveals divergence times that are more consistent with paleontological estimates than previous studies. Establishing a new phylogenetic pattern with accurate divergence dates for bony fishes illustrates several areas where the fossil record is incomplete and provides critical new insights on diversification of this important vertebrate group. PMID:23788273

Broughton, Richard E; Betancur-R, Ricardo; Li, Chenhong; Arratia, Gloria; Ortí, Guillermo

2013-04-16

168

Sexual dimorphism of the bony labyrinth: a new age-independent method.  

UK PubMed Central (United Kingdom)

Currently in physical anthropology there is a need for reliable methods of sex estimation for immature individuals and highly fragmented remains. This study develops a sex estimation technique from discriminant function analysis of the bony labyrinth as it matures before puberty and can survive taphonomic conditions that would destroy most other skeletal material. The bony labyrinth contains the organs of hearing and balance. For this reason biologists and paleoanthropologists have undertaken research in this area to understand evolutionary changes in locomotion. Prior studies have found clear differences between species, but within-species variation has not been satisfactorily investigated. 3D segmentations of the left and right labyrinths of 94 individuals from a Cretan collection were generated and measured. Mean measurements of height, width, size, and shape indices were analyzed for sexual dimorphism, bilateral asymmetry, and measurement error. Significant sexual dimorphism was detected for several measurements. For sex estimation, the single best variable was the radius of curvature of the posterior semicircular canal, which achieved 76% accuracy. Two multivariate functions increased accuracy to 84%. Although these equations are less accurate than equations for complete long bones and crania, they appear to be as accurate as or better than other techniques for sexing immature individuals and temporal bones.

Osipov B; Harvati K; Nathena D; Spanakis K; Karantanas A; Kranioti EF

2013-06-01

169

Bony anatomic variants of the paranasal sinuses and nasal septum. Comparison between normal and chronic sinusitis  

International Nuclear Information System (INIS)

Agger nasi cells, concha bullosa, Haller's cells and deviation of the nasal septum were evaluated with coronal plane computerized tomographic (CT) scanning in patients with normal paranasal sinuses (44 cases) and patients with chronic sinusitis (91 cases). Agger nasi cells were present in 68 (50.4%) of cases. Concha bullosa was present in 39 cases (28.9%), Haller's cells were present in 15 cases (11.1%), and deviation of the nasal septum was present in 64 cases (47.4%). Haller's cells were more commonly encountered in cases with normal paranasal sinuses (20.5%), than in cases with chronic sinusitis (6.6%). Other bony structural variations were noted at a similar frequency in both groups. Each sinus (frontal sinus, ethmoid sinus, maxillary sinus and sphenoid sinus) of patients with chronic sinusitis was then evaluated separately. Agger nasi cells were observed more frequently in chronic frontal sinusitis and ethmoid sinusitis compared to subjects with normal sinuses. Concha bullosa was observed more frequently in cases with normal frontal sinuses and ethmoid sinuses than in cases of chronic frontal sinusitis and ethmoid sinusitis. Haller's cells and deviation of the nasal septum were observed at a similar frequency in both groups. Based on these results, it was thought that these bony structural variations sometimes disturbed the reopening of the normal ventilation and drainage pathways of the paranasal sinuses at the stage of acute sinusitis. These nasal ventilatory disturbances may predispose the patient to recurrent sinusitis, and may finally result in chronic sinusitis. (author)

1996-01-01

170

Multi-locus phylogenetic analysis reveals the pattern and tempo of bony fish evolution.  

UK PubMed Central (United Kingdom)

Over half of all vertebrates are "fishes", which exhibit enormous diversity in morphology, physiology, behavior, reproductive biology, and ecology. Investigation of fundamental areas of vertebrate biology depend critically on a robust phylogeny of fishes, yet evolutionary relationships among the major actinopterygian and sarcopterygian lineages have not been conclusively resolved. Although a consensus phylogeny of teleosts has been emerging recently, it has been based on analyses of various subsets of actinopterygian taxa, but not on a full sample of all bony fishes. Here we conducted a comprehensive phylogenetic study on a broad taxonomic sample of 61 actinopterygian and sarcopterygian lineages (with a chondrichthyan outgroup) using a molecular data set of 21 independent loci. These data yielded a resolved phylogenetic hypothesis for extant Osteichthyes, including 1) reciprocally monophyletic Sarcopterygii and Actinopterygii, as currently understood, with polypteriforms as the first diverging lineage within Actinopterygii; 2) a monophyletic group containing gars and bowfin (= Holostei) as sister group to teleosts; and 3) the earliest diverging lineage among teleosts being Elopomorpha, rather than Osteoglossomorpha. Relaxed-clock dating analysis employing a set of 24 newly applied fossil calibrations reveals divergence times that are more consistent with paleontological estimates than previous studies. Establishing a new phylogenetic pattern with accurate divergence dates for bony fishes illustrates several areas where the fossil record is incomplete and provides critical new insights on diversification of this important vertebrate group.

Broughton RE; Betancur-R R; Li C; Arratia G; Ortí G

2013-01-01

171

Type IIb bony mallet finger: is anatomical reduction of the fracture necessary?  

Science.gov (United States)

One-third of all mallet fingers are associated with a fracture. Many different management strategies have been described. Some authors recommend nonsurgical management for all mallet fractures. In contrast, others suggest mandatory open reduction and internal fixation for bony mallet injuries with a large displaced dorsal fragment and associated distal interphalangeal (DIP) joint subluxation. We retrospectively studied 3 cases of a mallet fracture with a large displaced dorsal fragment and subsequent DIP joint subluxation managed with closed reduction using only percutaneous pinning of the DIP joint. All 3 patients had satisfactory pain-free and functional clinical outcomes at their particular follow-up (4, 6, or 19 months). Closed reduction and internal fixation of the subluxated joint using only Kirschner wires produced satisfactory outcomes for the 3 type IIb bony mallet fingers. Anatomical reduction of the fracture may be unnecessary in patients such as those in our case series. One aim of this pilot study is to justify larger, prospective studies. PMID:23710479

Neuhaus, Valentin; Thomas, Matthew A; Mudgal, Chaitanya S

2013-05-01

172

Aktywno?? proliferacyjna b?ony ?luzowej jelita grubego - metody oceny, czynniki i mechanizmy reguluj?ce, implikacje kliniczne  

Directory of Open Access Journals (Sweden)

Full Text Available W ostatnich latach obserwuje si? wzrost zainteresowania badaniami nad proliferacj? b?ony ?luzowej jelita grubego, poniewa? udowodniono, ?e mog? one mie? znaczenie dla zrozumienia mechanizmów karcynogenezy. Zaburzenia regulacji wzrostu b?ony ?luzowej jelita grubego nale?? do istotnych czynników odpowiedzialnych za powstanie i rozwój nowotworów. Do metod pomiaru aktywno?ci proliferacyjnej b?ony ?luzowej nale??: indeks mitotyczny, cytometria przep?ywowa, techniki immunohistochemiczne (BrdU, PCNA, Ki-67), aktywno?? dekarboksylazy ornitynowej, kinazy tymidynowej oraz ocena ilo?ciowa fosforylacji tyrozyny bia?ek b?ony ?luzowej. W?ród czynników stymuluj?cych proliferacj? b?ony ?luzowej jelita grubego wymienia si? sk?adniki pokarmowe (t?uszcze zwierz?ce, etanol), kwasy ?ó?ciowe, poliaminy, prostaglandyny, gastryn?, czynniki wzrostowe, starzenie si? ludzi i zwierz?t, a w?ród hamuj?cych - wap?, bakteri? Bifidobacterium longum, proglumid, somatostatyn? i niesteroidowe leki przeciwzapalne. Wzrost aktywno?ci proliferacyjnej obserwowano na ca?ej d?ugo?ci jelita grubego u chorych ze stanami przedrakowymi i rakiem tego narz?du. Badania aktywno?ci proliferacyjnej znajduj? zastosowanie przy wprowadzaniu nowych metod zapobiegania, prognozowania, monitorowania i leczenia raka jelita grubego u ludzi.

Justyna Kotynia; Anna Kropiwnicka; Ewa Ma?ecka-Panas

1999-01-01

173

Linhas escleróticas metafisárias em crianças e adolescentes em uso de alendronato Sclerotic metaphyseal lines in children and adolescents treated with alendronate  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUÇÃO: Os bisfosfonatos inibem a reabsorção óssea pela interferência na ação dos osteoclastos. Dentre os efeitos adversos, as linhas escleróticas em metáfise de ossos longos são descritas como principal alteração radiográfica na faixa etária pediátrica. OBJETIVO: Avaliar a frequência de alterações radiográficas causadas pelo alendronato utilizado em crianças e adolescentes com baixa densidade óssea ou calcinose. PACIENTES E MÉTODOS: Foi realizado um estudo do tipo coorte retrospectiva analisando-se prontuários de 21 pacientes que fizeram uso de alendronato semanal por no mínimo 10 meses. Os pacientes realizaram radiografias de ossos longos antes do início do alendronato e aproximadamente um ano após o seu uso. RESULTADOS: Onze pacientes (52,3%) apresentaram linhas escleróticas em metáfise dos ossos longos. A localização mais frequente foi em tíbia (8/11 pacientes), seguida de fêmur (7/11), úmero (6/11), rádio (4/11), ulna (3/11) e fíbula (2/11). Nenhum paciente apresentou regressão das alterações radiográficas durante o tempo de evolução (até 1,1 ano após a suspensão do alendronato). CONCLUSÃO: Se usado com critério, o alendronato é seguro e as alterações radiográficas não mostraram ter um significado mais importante.INTRODUCTION: Bisphosphonates inhibit bone resorption by interfering with the action of osteoclasts. Among the adverse effects, sclerotic lines observed in the metaphysis of long bones have been described as the main imaging finding in pediatric patients. OBJECTIVE: To evaluate the frequency of radiographic changes caused by alendronate in children and adolescents with low bone density or calcinosis. PATIENTS AND METHODS: We conducted a cross-sectional study with 21 patients who were treated with once-weekly alendronate for at least 10 months. Patients underwent x-rays of long bones before the start of alendronate and approximately one year after its use. RESULTS: Eleven patients (52.3%) had sclerotic lines in the metaphysis of long bones. The most frequent site was the tibia (8/11 patients), followed by the femur (7/11), humerus (6/11), radius (4/11), ulna (3/11), and fibula (2/11). Regression of radiographic changes during the study period (up to 1.1 years after discontinuation of alendronate) was not observed. CONCLUSION: If used carefully, alendronate is safe and radiographic changes have not been shown to be clinically relevant.

Érika C.C. Silva; Maria Teresa R.A. Terreri; Tania C.M. de Castro; Cássia P.L. Barbosa; Artur R.C. Fernandes; Maria Odete E. Hilário

2010-01-01

174

Relative efficacy of radiographic and radionuclide bone surveys in the detection of the skeletal lesions of histiocytosis X  

Energy Technology Data Exchange (ETDEWEB)

Radionuclide studies have been considered a more sensitive indicator of the presence of the bony lesions of histiocytosis X in children that have radiographic bone surveys. Our results suggest that the opposite is true. Although positive correlation between bone scans and radiographs was found in eight of nine patients, only 35% of the individual lesions visible on radiographs were seen on radionuclide studies. Results of radionuclide studies did not correlate with age or sex of the patient, presence or duration of symptoms, radiographic appearance, or anatomic location of lesions. Our results suggest that the radiographic skeletal survey is more sensitive than radionuclide studies in detecting the skeletal lesions of histiocytosis X.

Parker, B.R. (Children' s Hospital, Stanford, CA); Pinckney, L.; Etcubanas, E.

1980-02-01

175

Clinical value of combined 153Sm-EDTMP and Yunke therapy for relief of metastatic bony pain  

International Nuclear Information System (INIS)

To evaluate the clinical value of combined 153Sm-EDTMP and Yunke therapy in metastatic bony pain. 210 patients with metastatic bony pain were treated using 153Sm-EDTMP or combined with Yunke. The effect of treatment were observed. The total pain relief rate in single 153Sm-EDTMP group was 83.7%, whereas in combined 153Sm-EDTMP with Yunke group was 94.7%. The latter was markedly higher than the former. The clinical value of combined 153Sm-EDTMP and Yunke therapy group in relief of metastatic bony pain is obvious. And it was safe and no significant adverse reaction was observed. The pain relief effect of combined 153Sm-EDTMP and Yunke therapy is better than the single 153Sm-EDTMP therapy

2002-01-01

176

Review of nomenclature revision of fibro-ossous lesions in the maxillofacial region  

International Nuclear Information System (INIS)

Fibro-osseous lesions are composed of connective tissue and varying amount of mineralized substances, which may be bony or cementum-like structures. It is necessary for oral radiologist to differentiate due to the tendency of these fibro-osseous lesions to show similar histopathologic appearances, while the management of each lesion is different. However we often encounter a little difficulty in judgement because there are some overlaps between concept of each lesions. So recently I suggest, we face a need to review basic concept and classification of several fibro-osseous jaw lesions. In this article, several fibro-osseous lesions, such as fibrous dysplasia, cemento-ossifying fibroma and cemento-osseous dysplasia, will be discussed basing on the review of literature. Particular emphasis will be made on the nomenclature revision of WHO's classification in 1992

2007-01-01

177

The bony crescent sign - a new sign of facial nerve schwannoma  

International Nuclear Information System (INIS)

[en] Schwannomas are relatively uncommon intracranial tumours. They most commonly involve the acoustic nerve followed in frequency by the trigeminal nerve. Other cranial nerves are rarely involved. Facial nerve schwannomas occurring within the petrous temporal bone are very rare. Their diagnosis may be missed prospectively even when appropriate computerized tomography (CT) scans are performed. Even in retrospect the site of abnormality may be difficult to identify, especially if there is an associated middle ear mass such as a cholesteatoma. In the 4 cases presented the facial nerve schwannoma was seen on high resolution CT as a soft tissue mass bounded anteriorly by a thin rim of bone. This bony crescent sign is a previously undescribed feature of facial nerve schwannoma which appears to be strongly indicative of the presence of this tumour. Recognition of this sign makes these tumours arising in the region of the geniculate ganglion easy to diagnose prospectively. 12 refs., 6 figs

1992-01-01

178

Arachnoid cyst of the middle fossa with paradoxical changes of the bony structures.  

Science.gov (United States)

Two patients with an arachnoid cyst of the middle fossa showed paradoxical changes of the adjoining bony structures of the skull. There was a diminution of the middle fossa and hyperplasia of the sphenoid sinus (pneumosinus dilatans) as well as a marked bulging of the squamous part of the temporal bone. In one case in which scinticisternography was performed, communication between the cyst and the subarachnoidal space was proven as well as an extremely slow cerebrospinal fluid circulation in the cyst. The pathogenesis of the cyst is discussed, based upon the structural changes of the skull, the angiographic findings and the locally disturbed cerebrospinal fluid circulation. The primary disturbance seems to be a temporal lobe agenesis. PMID:1004704

Seur, N H; Kooman, A

1976-01-01

179

Arachnoid cyst of the middle fossa with paradoxical changes of the bony structures.  

UK PubMed Central (United Kingdom)

Two patients with an arachnoid cyst of the middle fossa showed paradoxical changes of the adjoining bony structures of the skull. There was a diminution of the middle fossa and hyperplasia of the sphenoid sinus (pneumosinus dilatans) as well as a marked bulging of the squamous part of the temporal bone. In one case in which scinticisternography was performed, communication between the cyst and the subarachnoidal space was proven as well as an extremely slow cerebrospinal fluid circulation in the cyst. The pathogenesis of the cyst is discussed, based upon the structural changes of the skull, the angiographic findings and the locally disturbed cerebrospinal fluid circulation. The primary disturbance seems to be a temporal lobe agenesis.

Seur NH; Kooman A

1976-01-01

180

Reconstruction of bony facial contour deficiencies with polymethylmethacrylate implants: case report  

Directory of Open Access Journals (Sweden)

Full Text Available Facial trauma can be considered one of the most serious aggressions found in the medical centers due to the emotional consequences and the possibility of deformity. In craniofacial surgery, the use of autologous bone is still the first choice for reconstructing bony defects or irregularities. When there is a shortage of donor bone or a patient refuses an intracranial operation, alloplastic materials such as polymethylmethacrylate (PMMA) can be used. The PMMA prosthesis can be pre-fabricated, bringing advantages such as reduction of surgical time, easy technical handling and good esthetic results. This paper describes the procedures for rehabilitating a patient with PMMA implants in the region of the face, recovering the facial contours and esthetics of the patient.

Ruy C. C. Abdo Filho; Thais M. Oliveira; Natalino Lourenço Neto; Carla Gurgel; Ruy C.C. Abdo

2011-01-01

 
 
 
 
181

Reconstruction of bony facial contour deficiencies with polymethylmethacrylate implants: case report  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english Facial trauma can be considered one of the most serious aggressions found in the medical centers due to the emotional consequences and the possibility of deformity. In craniofacial surgery, the use of autologous bone is still the first choice for reconstructing bony defects or irregularities. When there is a shortage of donor bone or a patient refuses an intracranial operation, alloplastic materials such as polymethylmethacrylate (PMMA) can be used. The PMMA prosthesis ca (more) n be pre-fabricated, bringing advantages such as reduction of surgical time, easy technical handling and good esthetic results. This paper describes the procedures for rehabilitating a patient with PMMA implants in the region of the face, recovering the facial contours and esthetics of the patient.

Abdo Filho, Ruy C. C.; Oliveira, Thais M.; Lourenço Neto, Natalino; Gurgel, Carla; Abdo, Ruy C.C.

2011-08-01

182

Accuracy of a transformation method to estimate muscle attachments based on three bony landmarks.  

UK PubMed Central (United Kingdom)

In this work, the accuracy of a transformation method to estimate muscle attachments based on three bony landmarks was assessed. A concept of mathematical error was introduced and applied to a data-set of 17 muscles' attachment lines from the shoulders of seven cadavers. Within the muscles' attachment lines from the studied data-set, mathematical error and anatomical variability average percentage values were 37.3 and 62.7%, respectively, for the scapula, and 54.4 and 45.6%, respectively, for the humerus. To reduce mathematical error in the transformation method presented, the plane formed by the three landmarks of the segment corresponding to the scaled muscles should neither be too close to the origin of the global coordinate system, nor too far away from muscle attachment locations to be transformed. The procedure outlined in this work allows the researcher to analyse the anatomical variability within a data-set.

Matias R; Andrade C; Veloso AP

2011-01-01

183

Reconstruction of facial defects after combat wounding using vascularized pedicled galeal and parietal bony grafts  

Directory of Open Access Journals (Sweden)

Full Text Available Combat wounds are basically extensive and destructive. Such injuries cause defects of soft and bone structures of the face and neck. During primary surgical management of maxillofacial combat wounds the principle of minimal bone and soft tissue debridement was respected. Definitive reconstruction of the defect was performed after two or three months, when infection was cured and adjacent tissues were restituted. Each combat wound leaves behind fibrous changes in surrounding tissues. Success of the reconstructive procedures is more certain if flaps with its own blood supply are used, either arterial or vascularized grafts from the other parts of body (by microvascular technique). This paper presents our experiences with galeal flap in reconstruction of facial soft tissue defects, as well as galea, together with external table of parietal bone in reconstruction of soft and bony tissues of maxillofacial region in 15 patients.

Jovi? Nebojša

2002-01-01

184

In vivo dosimetric study for a jaw-solitary-bony plasmacytomas-electron-beam-therapy  

International Nuclear Information System (INIS)

Some superficial tumors are treated with high energy electron beams. The dose distribution is rather complex, due to the beam crossing different electronic densities' materials. In the present work, the dose distribution in a jaw's-solitary-bony-plasmacytomas-treatment has been studied, to which 15 MeV electron beam was, initially, prescribed. Using lithium fluoride thermoluminescent dosimeters, the dose was evaluated on skin surface, behind the jaw, and, also, behind a lead shield designed to oral cavity protection. It was determined that the dose transmitted through the shield was 16% of the prescription dose, equivalent to 32 cGy, and, according to the medical staff, the treatment was modified to the 12 MeV-energy, resulting in a reduction to 8 cGy. It was assessed the influence of electron backscattering, resulting in a increase of the bolus thickness around the lead. (author)

2009-01-01

185

A clinico-radiologic study of bony remodeling of the fractured condyles in children  

Energy Technology Data Exchange (ETDEWEB)

Bony remodeling pattern of condyle fractures in children are different from in adult for growing of condyle, also might affect treatment and prognosis of the condyle fracture. Subjects of this clinical and radiologic study were 26 temporomandibular joints diagnosed as condyle fracture in 23 patients under 15 years old age, They were treated with conservative method at Dental Hospital of Yonsei University from Jan., 1986 to Oct., 1994. Bony remodeling related with fracture pattern was evaluated. The results obtained are as follows: 1. The ratio of male to female in patients with condyle fracture was 1 : 0.9 and the difference of sex ratio was not noted. Comparing with preschool-age group and school-age group, age frequency was higher in preschool-age group (83%). 2. Fallen down (54%) was the most frequent cause of condyle fractures. Traffic accident and slip down were followed. 3. The most common clinical sign of condyle fractures was tenderness to palpation (19 cases). Mouth opening limitation (17 cases), swelling (7 cases), malocclusion (3 cases) were next in order. 4. According to sites of condyle fractures, unilateral fractures were in 20 patients and bilateral fractures in 3 patients, therefore total 23 patients-26 cases of condyle fracture were observed. According to fracture distribution, condyle fractures were in 10 patients (44%). Condyle fractures with symphysis fracture (9 patients, 39%), condyle fractures with ascending ramus fracture (2 patients, 9%), condyle fracture with mandibular body fracture (1 patient, 4%), and condyle fractures with mandibular angle fracture (1 patient, 4%) were followed. 5. In displacement pattern of fractured fragment of mandibular condyle, displacement (17 cases, 66%) was most common. Dislocation (5 cases, 19%) and deviation (4 cases, 15%) were next in order. 6. During the observation period of fractured condyles, remodeling patterns of fracture sites related with articular fossa were observed with usual congealer shape in 23 cases and with prominently different shape in 3 cases.

Cho, Jeong Shin; Park, Chang Seo [Department of Dentistry, The Graduate School, Yonsei University, Seoul (Korea, Republic of)

1995-08-15

186

A clinico-radiologic study of bony remodeling of the fractured condyles in children  

International Nuclear Information System (INIS)

Bony remodeling pattern of condyle fractures in children are different from in adult for growing of condyle, also might affect treatment and prognosis of the condyle fracture. Subjects of this clinical and radiologic study were 26 temporomandibular joints diagnosed as condyle fracture in 23 patients under 15 years old age, They were treated with conservative method at Dental Hospital of Yonsei University from Jan., 1986 to Oct., 1994. Bony remodeling related with fracture pattern was evaluated. The results obtained are as follows: 1. The ratio of male to female in patients with condyle fracture was 1 : 0.9 and the difference of sex ratio was not noted. Comparing with preschool-age group and school-age group, age frequency was higher in preschool-age group (83%). 2. Fallen down (54%) was the most frequent cause of condyle fractures. Traffic accident and slip down were followed. 3. The most common clinical sign of condyle fractures was tenderness to palpation (19 cases). Mouth opening limitation (17 cases), swelling (7 cases), malocclusion (3 cases) were next in order. 4. According to sites of condyle fractures, unilateral fractures were in 20 patients and bilateral fractures in 3 patients, therefore total 23 patients-26 cases of condyle fracture were observed. According to fracture distribution, condyle fractures were in 10 patients (44%). Condyle fractures with symphysis fracture (9 patients, 39%), condyle fractures with ascending ramus fracture (2 patients, 9%), condyle fracture with mandibular body fracture (1 patient, 4%), and condyle fractures with mandibular angle fracture (1 patient, 4%) were followed. 5. In displacement pattern of fractured fragment of mandibular condyle, displacement (17 cases, 66%) was most common. Dislocation (5 cases, 19%) and deviation (4 cases, 15%) were next in order. 6. During the observation period of fractured condyles, remodeling patterns of fracture sites related with articular fossa were observed with usual congealer shape in 23 cases and with prominently different shape in 3 cases.

1995-01-01

187

Bony anatomic variants of the paranasal sinuses and nasal septum. Comparison between normal and chronic sinusitis  

Energy Technology Data Exchange (ETDEWEB)

Agger nasi cells, concha bullosa, Haller`s cells and deviation of the nasal septum were evaluated with coronal plane computerized tomographic (CT) scanning in patients with normal paranasal sinuses (44 cases) and patients with chronic sinusitis (91 cases). Agger nasi cells were present in 68 (50.4%) of cases. Concha bullosa was present in 39 cases (28.9%), Haller`s cells were present in 15 cases (11.1%), and deviation of the nasal septum was present in 64 cases (47.4%). Haller`s cells were more commonly encountered in cases with normal paranasal sinuses (20.5%), than in cases with chronic sinusitis (6.6%). Other bony structural variations were noted at a similar frequency in both groups. Each sinus (frontal sinus, ethmoid sinus, maxillary sinus and sphenoid sinus) of patients with chronic sinusitis was then evaluated separately. Agger nasi cells were observed more frequently in chronic frontal sinusitis and ethmoid sinusitis compared to subjects with normal sinuses. Concha bullosa was observed more frequently in cases with normal frontal sinuses and ethmoid sinuses than in cases of chronic frontal sinusitis and ethmoid sinusitis. Haller`s cells and deviation of the nasal septum were observed at a similar frequency in both groups. Based on these results, it was thought that these bony structural variations sometimes disturbed the reopening of the normal ventilation and drainage pathways of the paranasal sinuses at the stage of acute sinusitis. These nasal ventilatory disturbances may predispose the patient to recurrent sinusitis, and may finally result in chronic sinusitis. (author).

Ikeda, Motohisa [Soka Municipal Hospital, Saitama (Japan); Watanabe, Isamu

1996-03-01

188

Outcomes after arthroscopic excision of the bony prominence in the treatment of tibial spine avulsion fractures.  

UK PubMed Central (United Kingdom)

PURPOSE: The purpose of this study was to determine the outcomes after arthroscopic excision of the bony prominence after a tibial spine avulsion fracture. METHODS: This study included 7 subjects (5 female and 2 male subjects; mean age, 21.4 years). All subjects underwent preoperative rehabilitation focused on range of motion (ROM) and swelling control. Postoperative rehabilitation focused on regaining symmetric knee hyperextension and flexion. Objective examinations and subjective surveys were obtained at least 1 year after surgery. RESULTS: All subjects achieved normal knee extension; 6 patients achieved normal knee flexion, whereas 1 patient had nearly normal flexion. Physical examination showed a negative Lachman test with a firm end point in all patients, and the mean side-to-side difference for the KT-1000 manual maximum test (MEDmetric, San Diego, CA) was 1.3 mm. No subjects required subsequent anterior cruciate ligament reconstruction. All subjects returned to their previous level of activity without instability symptoms. At a mean of 5.7 years after surgery, the mean International Knee Documentation Committee subjective survey score was 90.6 points overall, with 4.7 out of 5 possible points for the instability question. At latest follow-up, the mean ROM was from 6° of hyperextension to 147° of flexion in the involved knee, compared with 6° of hyperextension to 148° of flexion for the noninvolved knee. CONCLUSIONS: The results of arthroscopic excision of the bony fragment after type II, III, or III+ tibial spine avulsion fracture are positive, with good stability, symmetric ROM, and high subjective scores. Most importantly, this procedure allows patients to regain full, symmetric hyperextension of the knee, avoiding the complications associated with extension loss. LEVEL OF EVIDENCE: Level IV, therapeutic case series.

Shelbourne KD; Urch SE; Freeman H

2011-06-01

189

Cranial bony decompressions in the management of head injuries: decompressive craniotomy or craniectomy?  

UK PubMed Central (United Kingdom)

OBJECTIVE: Decompressive surgery is one of the available options in dealing with traumatic brain injury (TBI) when clinical and radiological evidence confirm that medical treatment may be insufficient. This can be achieved either by complete removal of the bone or by allowing it to float, but the indications and utility of these are yet to be resolved. This study examines the indications and outcome for both procedures. MATERIALS AND METHODS: Review of all cases of bony decompression done at the Memfys Hospital for Neurosurgery, Enugu, Nigeria from August 2002 to May 2010. Prospectively recorded data of CT, MRI, operating room, clinics and wards were utilized. ResULTS: There were 38 patients out of whom 35 were males and 3 females. The mean age was 36 years (range 15-80). The causes of the predisposing TBI were road traffic accidents (RTA) (79%), gunshot (10.5%), and assault (7.9%). Decompressive surgery was unilateral in 36 and bi-frontal in 2. Decompressive craniectomy with bone stored in anterior abdominal wall pocket was done in 8 patients and decompressive craniotomy with bone left in situ in 30. Of the latter, bone was unsecured and allowed to float in 13 and the craniotomy was lightly anchored with sutures in 17 patients. Surgery was performed within 24 h in 68.4% of cases. Mortality was 21.1% overall but was up to 25% in the more severely injured patients who had craniectomy. CONCLUSION: Bony decompression is useful in the management of head trauma. Careful selection of cases and appropriate radiological assessment are important and will guide decision for either craniotomy or craniectomy.

Mezue WC; Ndubuisi C; Ohaegbulam SC; Chikani M; Erechukwu U

2013-07-01

190

[Benign vocal fold lesions].  

UK PubMed Central (United Kingdom)

Benign vocal fold lesions are grouped in lesions arising from the epithelium like papillomas, lesions affecting the Reinke's space (nodules, polyps, cysts, Reinkes's edema as a form of chronic laryngitis) and lesions affecting the arytenoid (granulomas). A multifactorial genesis is assumed. Main symptoms are dysphonia and hyperfunctional vocal behavior that might also be a cause of these lesions.

Pickhard A; Reiter R

2013-05-01

191

The characteristics of bony ankylosis of the facet joint of the upper cervical spine in rheumatoid arthritis patients  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This study investigated the bony ankylosis of the upper cervical spine facet joints in patients with a cervical spine involvement due to rheumatoid arthritis (RA) using computed tomography (CT) and then examined the characteristics of the patients showing such ankylosis. Forty-six consecutive patien...

Iizuka, Haku; Nishinome, Masahiro; Sorimachi, Yasunori; Ara, Tsuyoshi; Nakajima, Takashi; Iizuka, Yoichi; Takagishi, Kenji

192

Free flap transfer for closure and interposition-arthroplasty in noma defects of the lateral face associated with bony ankylosis.  

Science.gov (United States)

Noma defects of the anterolateral face are often associated with fibrous or bony ankylosis fusing the mandibula to the skull base. According to the extent of the ankylosis, the temporomandibular joint mobility can be restricted or even completely frozen. In third world conditions the surgical approach to severe forms of bony ankylosis consists of a single linear opening osteotomy (trismus release) and the closure of the noma defect with locoregional flaps. Relapse of jaw immobility is common and may be caused by minor bone resection, the lack of adequate postoperative physiotherapy, or even the scarring of the defect coverage. In 4 years the authors have gained increasing experience with folded free flaps for simultaneous closure of outer and inner lining of large noma defects and the maintenance and training of re-established jaw function by the use of a dynamic external distractor fixed between the zygoma and the mandibular body. The authors report the bony reankylosis can be reduced by extended wedge osteotomies of the bony bridge and tip-like shaping of the ascending mandibular ramus. To preclude the reossification of the osteotomy site and fibrous scar formation, a dermofatty or muscular tail of the free flap is interposed into the bone gap. Two cases were treated according to this concept with a free parascapular and a latissimus dorsi flap in combination with simultaneous arthroplasty. During a 6-month follow-up period, no signs of a recurrent reduction of mandibular movement were noted in either case. PMID:15346015

Giessler, Goetz A; Schmidt, Andreas B; Deubel, Ute; Cornelius, C-Peter

2004-09-01

193

Quantitative computed tomography as a test of endurance for evaluation of bony plates; Utilizacao da tomografia computadorizada quantitativa como teste de resistencia para avaliacao de placas osseas  

Energy Technology Data Exchange (ETDEWEB)

Quantitative computed tomography was used to determine the radiodensity of bony plates. The CT scans provided information regarding radiodensity of bony plates and allowed to verify the uniformity of bone mineral density in their scope. The proposed methodology should be considered as another tool for determining the resistance of these biomaterials. (author)

Melo Filho, E.V.; Costa, L.A.V.S.; Oliveira, D.C. [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil); Freitas, P.M.C. [Escola de Veterinaria - Universidade Federal de Minas Gerais - Belo Horizonte, MG (Brazil); Teixeira, M.W.; Costa, F.S. [Universidade Federal Rural de Pernambuco - Recife, PE (Brazil)

2012-06-15

194

Description of patients with bony tumors treated with prosthesis in reconstruction in the Servicio de Ortopedia at the Hospital Rafael Angel Calderon Guardia 2000-2006  

International Nuclear Information System (INIS)

The use of prosthesis in reconstruction for the management of extensive tumor bone lesions. The study of six patients treated is performed at the Hospital Rafael Angel Calderon Guardia, who were treated for aggressive tumors in the period 2001-2006. Bony tumors are conceptualized, as well as fundamental aspects of cell biology in its development and the classification of the same. Also, relevant information is included with relation to the most frequent indications and possible treatments. In all six cases was placed the rescue prosthesis, four of them has been obtained excellent results. Limb amputation has been the only alternative until the decade of the 70 and survival rates with this treatment were 10 to 20% survival at 5 years. Today, with advances in chemotherapy and limb salvage prosthesis, patients without metastases at diagnosis have a survival of 65 to 75% at five years. The study has made it possible to simultaneously to analyze some aspects of care to these patients; such as: time of biopsy, time of diagnosis, time of initiation of chemotherapy and surgical intervention time. Through this study has concluded that when referring to a malignant tumor of bone is absolutely essential that the process of diagnosis and initiation of treatment of limb salvage surgery are addressed as soon as possible. Finally, some recommendations are raised to strengthen the treatment of malignant tumors in the Hospital Rafael Angel Calderon Guardia. (author)

2007-01-01

195

Haemocytes play a commensal rôle in the synthesis of the dihydroxybenzoate required as a precursor for sclerotization of the egg case (ootheca) in the cockroach Periplaneta americana (L).  

Science.gov (United States)

The secretions of the two colleterial glands give rise to the walls of the ootheca which, when hardened, serve to protect fertilised eggs in the cockroach P. americana. The larger left gland (LCG) secretes a ?-D-glucoside of 3,4-dihydroxybenzoate, several proteins (oothecins), calcium oxalate crystals and a latent phenoloxidase enzyme. The smaller right gland (RCG) secretes a ?-glucosidase. When the two secretions mix in the genital vestibulum, the glucoside is hydrolyzed to glucose and free dihydroxybenzoate, which is then oxidized by the phenoloxidase to the o-benzoquinone, which cross-links the oothecins Scanning and thin section electron microscopy (EM) showed haemocytes adhering to the LCG. The haemocytes were obtained by washing the gland with insect saline; and, when they were incubated with labelled tyrosine, they showed an enhanced ability to decarboxylate L-p-tyrosine to tyramine and then deaminate and oxidize tyramine to give p-hydroxyphenylacetate. After removal of adhering haemocytes, the LCG was no longer able to decarboxylate tyrosine. Injection of ?-ecdysone into the abdomens of recently emerged adult females inhibited synthesis of a phenolic glucoside in the developing LCG but not of ?-glucosidase produced by RCG. Furthermore, injecting inhibitors of the decarboxylase and monoamineoxidase enzymes partly closed down synthesis in vivo of the phenolic glucoside by LCG. Therefore, in the adult female cockroach, tyramine was converted to p-hydroxyphenylacetate in the haemocytes and then transferred to the gland where it was hydroxylated to 3,4-dihydroxyphenylacetate, which gave rise to a dihydroxybenzoate. Evidence suggested that biosynthesis of the oothecal sclerotizing agent could be controlled by juvenile hormone (JH) acting on the LCG or on haemocytes adhering to the gland. PMID:20716385

Whitehead, D L

2010-08-18

196

Haemocytes play a commensal role in the synthesis of the dihydroxybenzoate required as a precursor for sclerotization of the egg case (ootheca) in the cockroach Periplaneta americana (L).  

UK PubMed Central (United Kingdom)

The secretions of the two colleterial glands give rise to the walls of the ootheca which, when hardened, serve to protect fertilised eggs in the cockroach P. americana. The larger left gland (LCG) secretes a ?-D-glucoside of 3,4-dihydroxybenzoate, several proteins (oothecins), calcium oxalate crystals and a latent phenoloxidase enzyme. The smaller right gland (RCG) secretes a ?-glucosidase. When the two secretions mix in the genital vestibulum, the glucoside is hydrolyzed to glucose and free dihydroxybenzoate, which is then oxidized by the phenoloxidase to the o-benzoquinone, which cross-links the oothecins Scanning and thin section electron microscopy (EM) showed haemocytes adhering to the LCG. The haemocytes were obtained by washing the gland with insect saline; and, when they were incubated with labelled tyrosine, they showed an enhanced ability to decarboxylate L-p-tyrosine to tyramine and then deaminate and oxidize tyramine to give p-hydroxyphenylacetate. After removal of adhering haemocytes, the LCG was no longer able to decarboxylate tyrosine. Injection of ?-ecdysone into the abdomens of recently emerged adult females inhibited synthesis of a phenolic glucoside in the developing LCG but not of ?-glucosidase produced by RCG. Furthermore, injecting inhibitors of the decarboxylase and monoamineoxidase enzymes partly closed down synthesis in vivo of the phenolic glucoside by LCG. Therefore, in the adult female cockroach, tyramine was converted to p-hydroxyphenylacetate in the haemocytes and then transferred to the gland where it was hydroxylated to 3,4-dihydroxyphenylacetate, which gave rise to a dihydroxybenzoate. Evidence suggested that biosynthesis of the oothecal sclerotizing agent could be controlled by juvenile hormone (JH) acting on the LCG or on haemocytes adhering to the gland.

Whitehead DL

2011-06-01

197

Distinct focal lesions of the femoral head: imaging features suggesting an atypical and minimal form of bone necrosis  

International Nuclear Information System (INIS)

Heading AbstractObjective. To document the imaging findings observed in patients with an unusual pattern of abnormality of the femoral head, most likely representing osteonecrosis.Design and patients. The imaging findings in 11 patients (10 men, 1 woman; age range 32-55 years) with a distinct lesion of the femoral head were reviewed with particular attention to the morphologic appearance, location, and extent of the lesion(s) in the proximal femur.Results. The 16 lesions identified in these patients extended to the subchondral area. Articular collapse was not evident in any hip. Radiography and CT showed areas of mixed bone sclerosis and osteolysis surrounded by sclerotic margins. On MR imaging, the signal intensity characteristics of the osseous lesion(s) were most commonly similar to those of fluid. Histopathologic findings, available in two hips, were typical of osteonecrosis. There was evidence of correlation of the site of the lesion with the known general distribution and anastomoses of arteries supplying the femoral head.Conclusion. A distinct, focal lesion of the femoral head is believed to represent an atypical form of bone necrosis. Its restriction to a small portion of the femoral head may relate to localized vascular anatomy. Recognition of the quite characteristic imaging findings can prevent misdiagnosis and may have implications for the prediction of the natural course of the disease. (orig.)

2002-01-01

198

Distinct focal lesions of the femoral head: imaging features suggesting an atypical and minimal form of bone necrosis  

Energy Technology Data Exchange (ETDEWEB)

Heading AbstractObjective. To document the imaging findings observed in patients with an unusual pattern of abnormality of the femoral head, most likely representing osteonecrosis.Design and patients. The imaging findings in 11 patients (10 men, 1 woman; age range 32-55 years) with a distinct lesion of the femoral head were reviewed with particular attention to the morphologic appearance, location, and extent of the lesion(s) in the proximal femur.Results. The 16 lesions identified in these patients extended to the subchondral area. Articular collapse was not evident in any hip. Radiography and CT showed areas of mixed bone sclerosis and osteolysis surrounded by sclerotic margins. On MR imaging, the signal intensity characteristics of the osseous lesion(s) were most commonly similar to those of fluid. Histopathologic findings, available in two hips, were typical of osteonecrosis. There was evidence of correlation of the site of the lesion with the known general distribution and anastomoses of arteries supplying the femoral head.Conclusion. A distinct, focal lesion of the femoral head is believed to represent an atypical form of bone necrosis. Its restriction to a small portion of the femoral head may relate to localized vascular anatomy. Recognition of the quite characteristic imaging findings can prevent misdiagnosis and may have implications for the prediction of the natural course of the disease. (orig.)

Theodorou, Daphne J. [Department of Radiology, School of Medicine, University of California, San Diego Medical Center, San Diego, California (United States); Department of Radiology, Veterans Administration Medical Center, San Diego, California (United States); Department of Radiology, Veterans Administration Medical Center, 3350 La Jolla Village Drive, San Diego, California 92161 (United States); Theodorou, Stavroula J.; Resnick, Donald [Department of Radiology, School of Medicine, University of California, San Diego Medical Center, San Diego, California (United States); Department of Radiology, Veterans Administration Medical Center, San Diego, California (United States); Haghighi, Parviz [Department of Pathology, Veterans Administration Medical Center, San Diego, California (United States)

2002-08-01

199

Type 1 IFN-induced protein MxA and plasmacytoid dendritic cells in lesions of morphea.  

UK PubMed Central (United Kingdom)

Morphea is an autoimmune sclerotic skin disease of unknown pathogenesis. As type 1 interferons (IFN) have been implicated in the pathogenesis of systemic sclerosis, we proposed that type 1 IFN promote localized inflammation and fibrosis in morphea. To investigate the expression of the type 1 IFN-inducible protein myxovirus A (MxA) and the presence of plasmacytoid dendritic cells (pDC) in lesions of morphea, lesional skin of 10 patients with morphea was examined by immunohistochemistry for the presence of the type 1 IFN-inducible protein, myxovirus A (MxA), and the pDC markers, CD123 and BDCA-2, and was compared with lesional skin of cutaneous lupus erythematosus, lichen planus and keloid. Lesional and non-lesional morphea skin was compared. MxA was expressed in the epidermis as well as the reticular dermis and subcutis in morphea. pDCs were abundant around vessels and between fibrous bundles. Non-lesional biopsies demonstrated little or no expression of MxA and pDC markers. Keloid showed minimal expression of MxA and pDC markers. We demonstrate the expression of type 1 IFN-related protein MxA and plasmacytoid DCs in lesional but not in non-lesional biopsies of morphea. These findings suggest a potential role for type 1 interferons in the pathogenesis of morphea.

Ghoreishi M; Vera Kellet C; Dutz JP

2012-06-01

200

CT of the canine lumbosacral spine in extension - flexion rotation; part I: bony window  

International Nuclear Information System (INIS)

The canine lumbosacral spine is examined radiographically in extended and flexed lateral position as well as ventrodorsally. Superimposition of bones hinders exact evaluation of the lumbosacral intervertebral foramen in case of cauda equina syndrome, especially when degenerative changes overlap. CT or MRI are more and more indicated to get reliable findings because myelography is not always of diagnostic value. For this study twelve dogs (7 German Shepherd dogs, 4 Cross-breds, and 1 Rottweiler) of different age and sex were taken which had been referred for CT examination of the lumbosacral area. Plain radiographs did not show abnormalities. The anaesthetized dogs were positioned in dorsal recumbency with the legs firstly extended and secondly flexed according to flexion-extension radiography. Slice thickness was 2 mm, the CT images were evaluated in both bony and soft tissue windows. Bony window easily showed vertebral bodies, vertebral canal, pedicles, vertebral laminae, and articular processes of L7 and S1. Median height of the vertebral canal did not change during extension or flexion at the level of L7 and the sacrum. Height and width of the intervertebral foramen and width of the interarcual foramen changed markedly from extension to flexion. Lateral recessus of the vertebral canal always could be observed as ventrolateral widening. In sagittal CT scans of the lumbosacral specimen of a normal German Shepherd dog cranial articular processes of the sacrum were detected to be responsible for maximum height or width of the intervertebral foramen. Evolving from the lateral recessus the intervertebral foramen was initially oval-shaped and got rounded and narrowed by the cranial articular process of the sacrum. Position and shape of the cranial articular processes of the sacrum were evaluated. Surface of the cranial articular processes of S1 were found even with articular spaces congruent, but some also appeared slightly concave or convex where incongruity of the joint space was present. Most of the dogs showed angles about 45 degrees, but some had 60 or 35 degrees and were classified steep or plane, respectively. Soft tissue formations such as intervertebral disk, ligaments, vessels, and nerves will be described in part II of this study. (author)

2002-01-01

 
 
 
 
201

Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Central giant cell lesions are benign intraosseous proliferative lesions that have considerable local aggressiveness. Nonsurgical treatment methods, such as intralesional corticosteroid injections, systemic calcitonin and interferon have been reported. Recently, bisphosphonates have been used to treat central giant cell lesions. A case of a 36-year-old male with a central giant cell lesion crossing the mandibular midline was treated with intralesional corticosteroids combined with alendronate sodium for the control of systemic bone resorption. The steroid injections and the use of bisphosphonates were stopped after seven months when further needle penetration into the lesion was not possible due to new bone formation. After two years, the bony architecture was near normal, and only minimal radiolucency was present around the root apices of the involved teeth. The patient was followed up for four years, and panoramic radiography showed areas of new bone formation. Thus far, neither recurrence nor side effects of the medication have been detected.

da Silva Newton; Carreira Aline Semblano; Pedreira Erick; Tuji Fabrício; Ortega Karem; de Jesus Viana Pinheiro João

2012-01-01

202

Radiotherapy for bony manifestations of Langerhans Cell Histiocytosis. Review and proposal for an international registry  

Energy Technology Data Exchange (ETDEWEB)

Purpose: to examine the role of radiotherapy (RT) in adult Langerhans Cell Histiocytosis (LCH) for osseous manifestations, to define open questions regarding RT, and to develop recommendations for the clinical decision-making and problem-solving process. Material and methods: a literature review using different medical databases was conducted including the last 3 decades, and resulting questions regarding the use of ionizing radiation were systematically compiled. Results: the literature review revealed a local control rate of 96% (93% complete remissions) in patients with osseous single-system disease and of 92% (76% complete remissions) in patients with bony involvement in multi-system disease. To increase our knowledge, a prospective registry has been developed to allow a differentiated analysis of RT outcome and definition of potential prognostic factors. Conclusion: ionizing radiation can be successfully applied as a single treatment or in combination with other therapies for osseous manifestations of LCH. It leads to high remission and local control rates. Nevertheless, many open questions still exist. A prospective clinical registry is proposed to define the exact role of RT in this disease and to develop future interdisciplinary treatment guidelines. (orig.)

Olschewski, T.; Seegenschmiedt, M.H. [Dept. of Radiotherapy and Radiation Oncology, Alfried Krupp Krankenhaus, Essen (Germany)

2006-02-01

203

Radiotherapy for bony manifestations of Langerhans Cell Histiocytosis. Review and proposal for an international registry  

International Nuclear Information System (INIS)

Purpose: to examine the role of radiotherapy (RT) in adult Langerhans Cell Histiocytosis (LCH) for osseous manifestations, to define open questions regarding RT, and to develop recommendations for the clinical decision-making and problem-solving process. Material and methods: a literature review using different medical databases was conducted including the last 3 decades, and resulting questions regarding the use of ionizing radiation were systematically compiled. Results: the literature review revealed a local control rate of 96% (93% complete remissions) in patients with osseous single-system disease and of 92% (76% complete remissions) in patients with bony involvement in multi-system disease. To increase our knowledge, a prospective registry has been developed to allow a differentiated analysis of RT outcome and definition of potential prognostic factors. Conclusion: ionizing radiation can be successfully applied as a single treatment or in combination with other therapies for osseous manifestations of LCH. It leads to high remission and local control rates. Nevertheless, many open questions still exist. A prospective clinical registry is proposed to define the exact role of RT in this disease and to develop future interdisciplinary treatment guidelines. (orig.)

2006-01-01

204

Automated bony region identification using artificial neural networks: reliability and validation measurements  

International Nuclear Information System (INIS)

[en] The objective was to develop tools for automating the identification of bony structures, to assess the reliability of this technique against manual raters, and to validate the resulting regions of interest against physical surface scans obtained from the same specimen. Artificial intelligence-based algorithms have been used for image segmentation, specifically artificial neural networks (ANNs). For this study, an ANN was created and trained to identify the phalanges of the human hand. The relative overlap between the ANN and a manual tracer was 0.87, 0.82, and 0.76, for the proximal, middle, and distal index phalanx bones respectively. Compared with the physical surface scans, the ANN-generated surface representations differed on average by 0.35 mm, 0.29 mm, and 0.40 mm for the proximal, middle, and distal phalanges respectively. Furthermore, the ANN proved to segment the structures in less than one-tenth of the time required by a manual rater. The ANN has proven to be a reliable and valid means of segmenting the phalanx bones from CT images. Employing automated methods such as the ANN for segmentation, eliminates the likelihood of rater drift and inter-rater variability. Automated methods also decrease the amount of time and manual effort required to extract the data of interest, thereby making the feasibility of patient-specific modeling a reality. (orig.)

2008-01-01

205

Three-dimensional shape differences in the bony pelvis of women with pelvic floor disorders.  

UK PubMed Central (United Kingdom)

INTRODUCTION AND HYPOTHESIS: The objective of this study was to determine whether the three-dimensional shape of the bony pelvis differs between women with and without pelvic floor disorders (PFDs). We predict that the levator ani attachment points for the pelvic floor are further displaced from one another in affected relative to unaffected women. METHODS: Pelvic shape was quantified by collecting coordinate data from landmarks located on three-dimensional reconstructions of magnetic resonance images of 19 PFD cases and 16 matched controls. Euclidean distance matrix analysis (EDMA) was used to quantify and compare pelvic shape using these landmark data. RESULTS: There were no significant group differences in age, parity, body mass, racial attribution, cesarean section, or hysterectomy status. After controlling for size as a confounding factor, EDMA results identified significant differences (p = 0.05) in the bispinous diameter (4 % proportionally larger) and distances defining lateral displacement of ischia from pubis (5-6 % proportionally larger) in cases compared to controls. CONCLUSIONS: Pelvic shape in women with PFDs is characterized by the proportional mediolateral enlargement of the pelvic midplane and ischial eversion near the subpubic arch, consistent with inferolateral migration of the attachment points for the levator ani and correspondingly lateral displacement. These movements may result in increased strain on the pelvic floor's muscular and connective tissues, increasing the risk of failure over a woman's lifetime.

Brown KM; Handa VL; Macura KJ; DeLeon VB

2013-03-01

206

Bony impingement depends on the bone morphology of the hip after total hip arthroplasty.  

UK PubMed Central (United Kingdom)

PURPOSE: The purpose of this study was to evaluate whether the bone morphology of the hip affects the range of motion (ROM) in total hip arthroplasty (THA). METHODS: Using the CT data of 63 patients who underwent THA, we calculated the ROM of flexion (Flex), internal rotation (Int-R) and external rotation (Ext-R) using 3D dynamic analysis software. We measured the distance between the anterior surface of the stem and anterior aspect of the greater trochanter (GTa length) at the cutting point and between the tip of the antero-inferior iliac spine (AIIS) and coronal plane of both femoral heads (AIIS length), as a parameter of the femur and pelvis, respectively. The relationship between the ROM, bone anatomy and impingement site was evaluated. RESULTS: We found a significant decrease in the ROM of Flex and the Int-R to be inversely proportional to the GTa and AIIS length. In Flex and Int-R, the anterior intertrochanteric region often impinges on the AIIS in patients with larger bone anatomy. CONCLUSIONS: We demonstrated that the bone morphology of the hip substantially affects the ROM of Flex and Int-R, especially in patients with large bone anatomy. For these patients we should consider bony impingement in THA.

Shoji T; Yasunaga Y; Yamasaki T; Mori R; Hamanishi M; Ochi M

2013-10-01

207

Multimodality imaging of tumor and bone response in a mouse model of bony metastasis.  

UK PubMed Central (United Kingdom)

Cancer drug development generally performs in vivo evaluation of treatment effects that have traditionally relied on detection of morphologic changes. The emergence of new targeted therapies, which may not result in gross morphologic changes, has spurred investigation into more specific imaging methods to quantify response, such as targeted fluorescent probes and bioluminescent cells. The present study investigated tissue response to docetaxel or zoledronic acid (ZA) in a mouse model of bony metastasis. Intratibial implantations of breast cancer cells (MDA-MB-231) were monitored throughout this study using several modalities: molecular resonance imaging (MRI) tumor volume and apparent diffusion coefficient (ADC), micro-computed tomography (µCT) bone volume, bioluminescence imaging (BLI) reporting cancer cell apoptosis, and fluorescence using Osteosense 800 and CatK 680-FAST. Docetaxel treatment resulted in tumor cell kill reflected by ADC and BLI increases and tumor volume reduction, with delayed bone recovery seen in µCT prefaced by increased osteoblastic activity (Osteosense 800). In contrast, the ZA treatment group produced similar values in MRI, BLI, and Osteosense 800 fluorescence imaging readouts when compared to controls. However, µCT bone volume increased significantly by the first week post-treatment and the CatK 680-FAST signal was slightly diminished by 4 weeks following ZA treatment. Multimodality imaging provides a more comprehensive tool for new drug evaluation and efficacy screening through identification of morphology as well as function and apoptotic signaling.

Hoff BA; Chughtai K; Jeon YH; Kozloff K; Galbán S; Rehemtulla A; Ross BD; Galbán CJ

2012-12-01

208

Adaptacja ?o??dka u chorych przewlekle przyjmuj?cych diklofenak - znaczenie angiogenezy i proliferacji komórek b?ony ?luzowej  

Directory of Open Access Journals (Sweden)

Full Text Available Niesteroidowe leki przeciwzapalne (nlpz) s? od wielu lat szeroko stosowan? grup? leków. S? one powodem wyst?powania w trakcie leczenia u wielu chorych ró?nie nasilonych objawów ubocznych ze strony przewodu pokarmowego. Przewlek?e ich stosowanie wywo?uje zjawisko adaptacji b?ony ?luzowej ?o??dka. Celem pracy jest ocena znaczenia angiogenezy i proliferacji komórek b?ony ?luzowej ?o??dka u pacjentów przewlekle przyjmuj?cych diklofenak. Badania przeprowadzono u 26 pacjentów przewlekle przyjmuj?cych (d?u?ej ni? 14 dni) diklofenak w dawce od 100 do 150 mg/dob?. Chorzy z chorob? wrzodow? i czynnym wrzodem, z potwierdzon? infekcj? Helicobacter pylori lub po leczeniu eradykacyjnym, spo?ywaj?cy przewlekle alkohol, pal?cy tyto? oraz przyjmuj?cy steroidy zostali wy??czeni. Grup? kontroln? stanowi?o 21 osób bez zmian histopatologicznych b?ony ?luzowej ?o??dka. U wszystkich badanych pobierano trzy bioptaty z cz??ci przedod?wiernikowej i trzonu ?o??dka. Bioptaty umieszczano w formalinie, a nast?pnie zatapiano w parafinie. Poci?te skrawki grubo?ci 4 ?m wybarwiano hematoksylin? i eozyn? w celu rutynowej oceny histopatologicznej. Materia? przeznaczony do oceny angiogenezy poddano reakcjom immunohistochemicznym z zastosowaniem przeciwcia? monoklonalnych przeciwko antygenowi ?ródb?onka naczy? CD31 (Dako, Dania). Aktywno?? proliferacyjn? (indeks proliferacji) komórek b?ony ?luzowej ?o??dka okre?lano, stosuj?c przeciwcia?a monoklonalne przeciwko PCNA (Novocastra, Anglia). Przeprowadzone badania nie wykaza?y istotnych ró?nic w aktywno?ci angiogenezy u chorych przewlekle przyjmuj?cych diklofenak w porównaniu z grup? kontroln?. W grupie leczonej diklofenakiem stwierdzono natomiast znamienny wzrost proliferacji komórek b?ony ?luzowej ?o??dka. Na podstawie uzyskanych wyników bada? mo?na stwierdzi?, ?e wzrost aktywno?ci proliferacyjnej komórek b?ony ?luzowej ?o??dka jest istotnym elementem ?o??dkowej adaptacji, w przeciwie?stwie do angiogenezy, która w tym procesie takiego znaczenia nie wykazuje.

Andrzej Hnatyszyn; Zdzis?aw Gapski; Grzegorz Kaczmarek; Artur Gontarewicz

1999-01-01

209

[The usefulness of high frequency ultrasonography in dermatological practice--ultrasound features of selected cutaneous lesions].  

UK PubMed Central (United Kingdom)

UNLABELLED: Typical diagnostic process in dermatology includes clinical assessment, dermoscopic and histopathologic examination. Microsonography was initiated in seventies and much progress in the development of high-frequency scanners occurred since that time. The aim of the study was the assessment of high frequency ultrasonography in dermatologic diagnostics. MATERIAL AND METHODS: Examination was performed with 30 MHz ultrasound transducer with 0,1 mm resolution and 7 mm penetration. We examined patients with benign and malignant neoplasms, cicatrical alopecia and morphea. RESULTS: Sonographically, the normal skin is composed of three layers: an epidermal entry echo, dermis and subcutaneous tissue. In healthy skin we can image small hypoechoic areas which correspond to hair folicules, vessels and sebaceous glands. Most of small skin neoplasmatic lesions were hypoechogenic and homogeneous on examination. Extensive lesions were multicomponent with normo-, hypo- and anechogenic structures. The assessment of lesion's boarders allows sometimes to conclude the invasiveness of the lesion. Areas of skin with clinically visible atrophy showed diffuse increasing of echogenicity. In early lesions, without accomplished fibrosis, diffuse decreasing of echogenicity can be observed, that is probably caused by inflammatory infiltration. In comparison to the healthy skin, the ultrasound scan of sclerotic skin shows a wide entry echo and highly reflective, thicker dermis as a result of the collagen fibers accumulation. CONCLUSIONS: Above data suggest that ultrasonographic examination may be a valuable dermatologic diagnostic tool that completes classical dermatologic diagnostics and helps to plan the treatment.

Szyma?ska E; Maj M; Majsterek M; Litniewski J; Nowicki A; Rudnicka L

2011-07-01

210

Extensa metaplasia ósea endometrial y exitoso embarazo espontáneo post tratamiento Bony metaplasia of the endometrium. Report of two cases  

Directory of Open Access Journals (Sweden)

Full Text Available We report a 28 year old female consulting for infertility and a 26-year-old woman consulting for severe dysmenorrhea. In both patients a osseous metaplasia of the endometrium was found. Both patients were subjected to a hysteroscopic resection of the osseous material and both achieved spontaneous pregnancies and term deliveries following the procedures. If the bony material is removed, normal pregnancies and deliveries are feasible afterwards, no matter how extensive is the the osseus metaplasia.

ALEJANDRO MANZUR Y; SERGIO VARELA C

2010-01-01

211

A prospective analysis of bony versus soft-tissue reconstruction for posterior mandibular defects.  

UK PubMed Central (United Kingdom)

BACKGROUND: Although reconstruction of anterior mandibular oncologic defects with bony free flaps is considered the standard method of treatment, the optimal reconstruction of posterior defects is controversial. The authors' goal was to compare outcomes using either a vascularized bone flap or a soft-tissue free flap for posterior mandibular reconstruction. METHODS: Data were collected prospectively on 74 patients undergoing posterior mandibular resection including the condyle. RESULTS: Twenty-four patients underwent vascularized bone flap reconstruction and 50 patients underwent soft-tissue free flap reconstruction. Patients undergoing vascularized bone flap reconstruction were significantly younger than those undergoing soft-tissue free flap reconstruction (47 versus 62 years, respectively; p = 0.0001) and had a lower American Society of Anesthesiologists class (2.6 versus 3.1, respectively; p = 0.001). There were no significant differences in total operative time, intensive care unit stay, or hospital stay. The complication rate was 33 percent for patients receiving vascularized bone flap reconstructions and 38 percent for patients receiving soft-tissue free flap reconstruction (p = 0.70). Mouth opening averaged 39.8 mm for patients with vascularized bone flap reconstructions and 46.4 mm for patients with soft-tissue free flap reconstructions (p = 0.09). Jaw deviation toward the resection side averaged 1.2 mm for vascularized bone flap reconstructions and 5.3 mm for soft-tissue free flap reconstructions (p = 0.02). There was no significant difference in the type of mechanical diet tolerated by either group (p = 0.83). CONCLUSIONS: With careful selection, good reconstructive results after posterior mandibular resection can be achieved with vascularized bone flap or soft-tissue free flaps. In appropriate candidates, vascularized bone flap reconstruction may result in better postoperative occlusion.

Hanasono MM; Zevallos JP; Skoracki RJ; Yu P

2010-05-01

212

[Clinical application of transport distraction osteogenesis arthroplasty in the treatment of temporomandibular joint bony ankylosis].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To explore the clinical application of transport distraction osteogenesis arthroplasty (TDOAP) in the treatment of temporomandibular joint (TMJ) bony ankylosis. METHODS: From December 1999 to December 2011, a total of 73 patients (89 sides of TMJ) underwent TDOAP were included. There were 39 males and 34 females with a mean age of 19.6 years (range: 3 - 60). Among them, 27 patients were recurrence cases and 30 cases were accompanied with micrognathia and obstructive sleep apnea-hypopnea syndrome (OSAHS). The mean preoperative degree of mouth opening was 6.6 mm (range: 1 - 20). After a release of ankylosis, a transport disc was performed and fixed to ramus with a distractor. Distraction began at Days 4 - 8 postoperation. The distraction rhythm and rate were 0.25 mm four times daily. Distraction stopped when planning distance was achieved. And a distractor was maintained in place for 3-6 months after completion of distraction and then removed. Active postoperative training of mouth opening was implemented. RESULTS: The mean distance of distraction was 15.3 mm (range: 12 - 23). The range of mouth opening of 65 patients increased to normal and bone formation in gaps were perfect. The mean follow-up period was 44.8 months (range: 18 - 102). Eight cases were recurrent. And 1/37 over 15 years old and 7/36 under 15 years old had reankylosis. CONCLUSIONS: TDOAP is an effective treatment for TMJ ankylosis. A pediatric patient, especially recurrent, should be operated after adolescence to decrease reankylosis. Micrognathia and OSAHS should be also considered during the treatment of ankylosis.

Liang C; Wang X; Yi B; Li ZL; Wang XX

2013-03-01

213

Bony engineering using time-release porous scaffolds to provide sustained growth factor delivery.  

UK PubMed Central (United Kingdom)

Microporous scaffolds designed to improve bony repair have had limited success; therefore, we sought to evaluate whether time-released porous scaffolds with or without recombinant bone morphogenetic protein 2 (rhBMP-2) could enhance stem cell osteoinduction. Custom-made 15/85 hydroxyapatite/?-tricalcium phosphate scaffolds were left empty (E) or filled with rhBMP-2 (E+), calcium sulfate (CS), or CS and rhBMP-2 (CS+). All scaffolds were placed in media and weighed daily. Conditioned supernatant was analyzed for rhBMP-2 and then used to feed human adipose-derived mesenchymal stem cells (ASCs). Adipose-derived mesenchymal stem cell ALP activity, OSTERIX expression, and bone nodule formation were determined. E scaffolds retained 97% (SD, 2%) of the initial weight, whereas CS scaffolds had a near-linear 30% (SD, 3%) decrease over 60 days. E+ scaffolds released 155 (SD, 5) ng of rhBMP-2 (77%) by day 2. In contrast, CS+ scaffolds released only 30 (SD, 2) ng (10%) by day 2, and the remaining rhBMP-2 was released over 20 days. Conditioned media from E+ scaffolds stimulated the highest ALP activity and OSTERIX expression in ACSs on day 2. However, after day 6, media from CS+ scaffolds stimulated the highest ALP activity and OSTERIX expression in ASCs. Adipose-derived mesenchymal stem cells exposed to day 8 CS+-conditioned media produced significantly more bone nodules (10.1 [SD, 1.7] nodules per high-power field) than all other scaffolds. Interestingly, day 8 conditioned media from CS scaffolds simulated significantly more bone nodules than either E or E+ scaffold (P < 0.05 for both). Time-released hydroxyapatite/?-tricalcium phosphate porosity provides sustained growth factor release, enhances ASC osteoinduction, and may result in better in vivo bone formation.

Szpalski C; Nguyen PD; Cretiu Vasiliu CE; Chesnoiu-Matei I; Ricci JL; Clark E; Smay JE; Warren SM

2012-05-01

214

Zmiany b?ony ?luzowej w zast?pczych prze?ykach wytworzonych z uszypu?owanych odcinków jelita cienkiego  

Directory of Open Access Journals (Sweden)

Full Text Available Celem bada? by?a ocena histologiczna zmian b?ony ?luzowej jelita cienkiego tworz?cego zast?pcze prze?yki u pacjentów z bliznowym zw??eniem oparzonego prze?yku. Badano 27 pacjentów ze sztucznym prze?ykiem od 6 miesi?cy do 40 lat po przeprowadzeniu operacji. Wycinki z b?ony ?luzowej pobierano podczas kontroli endoskopowej wytworzonych prze?yków. Stwierdzono obecno?? zmian zanikowych b?ony ?luzowej, ocenianej wed?ug klasyfikacji Laumoniera i wsp., oraz wyst?powanie zmian zapalnych o ró?nym nat??eniu. Uszkodzenia i przekszta?cenia te s? nast?pstwem kra?cowej redukcji wch?aniania jelitowego oraz ograniczenia przep?ywu krwi po operacyjnym wytworzeniu nowego prze?yku. Przemiany te s? tak?e wynikiem adaptacji jelita cienkiego do transmisji nie strawionego pokarmu z jamy ustnej do ?o??dka. Wyst?powanie zmian w prze?ykach funkcjonuj?cych w ró?nym czasie od ich wytworzenia wskazuje, ?e osi?gaj? one do?? szybko pewien okre?lony poziom i utrzymuj? si? na nim latami bez wyra?nego post?pu.

Krzysztof Grabowski; Jerzy Rabczy?ski; Teresa Rosi?ska

1998-01-01

215

Two-year clinical evaluation of three adhesive systems in non-carious cervical lesions  

Directory of Open Access Journals (Sweden)

Full Text Available OBJECTIVES: Adhesive systems are continuously being introduced to Dentistry, unfortunately often without sufficient clinical validation. The aim of this study was to evaluate the clinical performance of cervical restorations done with three different adhesive systems. MATERIAL AND METHODS: 158 non-carious cervical lesions of 23 patients were restored with a nanofilled composite resin (Filtek Supreme, 3M/ESPE) combined with Single Bond (3M/ESPE, group SI), Clearfil SE (Kuraray Medical Inc., group CL) and Xeno III (De Trey Dentsply, group XE). In groups SI-B, CL-B and XE-B, the outer surface of the sclerotic dentin was removed by roughening with a diamond bur before application of the respective adhesive systems. In groups CL-BP and XE-BP, after removal of the outer surface of the sclerotic dentin with the bur, the remaining dentin was etched with 37% phosphoric acid and the self-etch adhesive systems Clearfil SE and Xeno III were applied, respectively. Lesions were evaluated at baseline, and restorations after 3 months, 1 year and 2 years using modified USPHS criteria. RESULTS: After 2 years, no significant difference was found between the retention rates of the groups (p >0.05). Although groups CL and SI showed significantly better marginal adaptation than group XE (p0.05). After 2 years no significant difference was observed among the marginal staining results of all groups (p>0.05). CONCLUSION: Although all adhesive systems showed similar retention rates, Clearfil SE and Single Bond showed better marginal adaptation than Xeno III after 2 years of follow-up.

Evrim Eliguzeloglu Dalkilic; Huma Omurlu

2012-01-01

216

Clinical evaluation of an all-in-one adhesive in non-carious cervical lesions with different degrees of dentin sclerosis.  

Science.gov (United States)

This randomized clinical trial compared the performance of an all-in-one adhesive (iBond) applied in sclerotic and non-sclerotic non-carious cervical lesions with that of a three-step etch-prime-bond adhesive (Gluma Solid Bond, SB). One-hundred and five lesions were randomly assigned to four groups according to adhesive, sclerosis scale and technique: 1) SB applied to lesions with sclerosis scale 1 and 2 (n=26); 2) iBond applied to lesions with sclerosis scale 1 and 2 (n=28); 3) iBond applied to lesions with sclerosis scale 3 and 4 (n=25) and 4) iBond applied with prior acid-etching to lesions with sclerosis scale 3 and 4 (n=26). A microfilled composite (Durafill VS) was used as the restorative material. The restorations were evaluated for retention, color match, marginal adaptation, anatomic form, cavosurface margin discoloration, secondary caries, pre- and post-operative sensitivity, surface texture and fracture at insertion (baseline), 6, 18 months and at 3 years using modified USPHS evaluation criteria (Alfa=excellent; Bravo=clinically acceptable; Charlie=clinically unacceptable). There was a high percentage of Bravo scores for marginal adaptation (4%-32%) and marginal discoloration (18%-60%) in Groups 2, 3 and 4, but all groups had <5% Charlie scores at 6 months and <10% Charlie scores at 18 months for retention and marginal discoloration, respectively. However, it should be noted that 13% of the restorations in Group 4 were not retained at three years. PMID:18666493

Ritter, André V; Heymann, Harald O; Swift, Edward J; Sturdevant, John R; Wilder, Aldridge D

217

An osseous lesion in a 10-year-old boy with Hodgkin's lymphoma: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Introduction Osseous involvement of Hodgkin's lymphoma is uncommon. When osteolytic lesions are seen on imaging it is important to evaluate potential other causes. Case presentation We report the case of a 10-year-old Caucasian boy who presented to our facility with a bony lesion of the right clavicle and enlarged cervical lymph nodes. A simultaneous biopsy of the lymph node and of the osteolytic process of his right proximal clavicle was performed and revealed two different kinds of lesions: a mixed cellularity Hodgkin's lymphoma and an osteochondroma. Conclusions Since the latter is a common benign bone tumor, which should not interfere with the staging of the lymphoma, we emphasize the importance of ensuring that all efforts are made to acquire a diagnostic biopsy of all atypical lesions.

van den Akker Machiel; Zudekov Vadiem; Moser Asher; Kapelushnik Joseph

2011-01-01

218

18F-FDG PET demonstrates previously unvisualised bony metastases in a lung cancer patient  

International Nuclear Information System (INIS)

[en] Full text: A 59-year-old male, presented to his local doctor with the trivial complaint of a persistent dry cough. On clinical examination he was found to have an enlarged right supraclavicular lymph node. He was investigated with chest X-ray, Computerised Tomography (CT) and Fine Needle Aspiration Cytology (FNAC) of the palpable node CT showed a right lung mass, bulky hilar, mediastinal, supraclavicular and cervical lymph nodes FNAC was inconclusive due to an insufficient tissue sample, but suggestive of non-Hodgkin's Lymphoma. Hence excisional node biopsy was required which revealed non-small cell lung cancer (NSCLC). Subsequent CT scans of the abdomen and pelvis for staging revealed no distant involvement. Therefore radical radiotherapy was planned to treat the locally advanced disease. Prior to treatment a Positron Emission Tomography (PET) scan was organised by his specialist as a baseline study to monitor therapy progress. Non-Attenuation corrected images of the chest, abdomen and pelvis were obtained 40 minutes post administration of 394 MBq 18F-FDG, on a Siemens 951/3IR PET scanner. The images were reconstructed using both Filtered Back Projection (FBP) and Ordered Subsets-Expectation Maximization (OSEM) algorithms. The images revealed extensive metastases particularly in the spine and pelvis, besides the known locally advanced thoracic disease A 99mTc MDP bone scan and plain film radiographs aimed at confirming bony metastases were negative, even though the bone scan noted a slight focus in the right fourth rib. The appearance suggested trauma, but a solitary bone metastasis could not be ruled out MRI of the spine confirmed the PET scan findings. Mr RD was to have curative radical radiotherapy, but after the PET results, it was decided to treat him palliatively. The value of 18F-FDG PET in staging some cancers such as NSCLC is widely accepted, in this case it was pivotal in altering the patient's management. Copyright (2002) The Australian and New Zealand Society of Nuclear Medicine Inc

2002-01-01

219

Tumefactive demyelinating lesions  

Energy Technology Data Exchange (ETDEWEB)

We studied 21 cases of pathologically confirmed tumefactive demyelinating lesions and reviewed the spectrum of tumefactive demyelinating lesions in the literature. Radiological features and clinical data were reviewed to characterize the lesions as consistent with a known demyelinating disease, most notably multiple sclerosis. Atypical clinical or radiological features (other than tumefaction) were noted. Most lesions were part of a clinical and/or radiological picture consistent with multiple sclerosis. No case strongly suggestive of variants or related diseases, such as Schilder`s disease or Balo`s concentric sclerosis, were found. There was one case suggestive of acute disseminated encephalomyelitis. Features which help distinguish the lesions from tumour are discussed. (orig.)

Dagher, A.P. [Thomas Jefferson Univ. Hospital, Philadelphia, PA (United States). Div. of Neuroradiology; Smirniotopoulos, J. [Thomas Jefferson Univ. Hospital, Philadelphia, PA (United States). Div. of Neuroradiology]|[Armed Forces Inst. of Pathology, Washington, DC (United States). Dept. of Radiological Pathology

1996-08-01

220

Tumefactive demyelinating lesions  

International Nuclear Information System (INIS)

We studied 21 cases of pathologically confirmed tumefactive demyelinating lesions and reviewed the spectrum of tumefactive demyelinating lesions in the literature. Radiological features and clinical data were reviewed to characterize the lesions as consistent with a known demyelinating disease, most notably multiple sclerosis. Atypical clinical or radiological features (other than tumefaction) were noted. Most lesions were part of a clinical and/or radiological picture consistent with multiple sclerosis. No case strongly suggestive of variants or related diseases, such as Schilder's disease or Balo's concentric sclerosis, were found. There was one case suggestive of acute disseminated encephalomyelitis. Features which help distinguish the lesions from tumour are discussed. (orig.).

1996-01-01

 
 
 
 
221

[Pulmonary lesions following bone marrow graft. Study of 35 cases  

UK PubMed Central (United Kingdom)

Lung biopsy of 35 patients with interstitial pneumonitis following bone marrow transplantation (BMT) have been studied histologically, ultrastructurally and by immunofluorescence. Among infectious diseases, cytomegaloviruses (CMV) are the more frequently found, whereas Pneumocystis carinii infections are more frequently found in immunocompromised hosts without BMT. CMV infections are related to severe chronic graft-versus-host disease in allogenic or mismatched BMT. Hemorrhagic pulmonary oedema and vascular damage might be the consequence of high doses of cyclosporin A or of disseminated intravascular coagulation. Granulomatous and fibrosing lesions corresponded in 2 cases to an eosinophilic pneumonitis and in 11 cases to an "idiopathic" diffuse interstitial pneumonitis. 2 patients had concomitant diffuse lung fibrosis, sclerotic plaques of the skin and Sjögren-like syndrome. The pulmonary and cutaneous scleroses had common features in the types of collagen and in the composition of the infiltrate. Both fibroses might result from a common pathogenic mechanism related to an immunologic conflict between the lymphocytes of the graft and the cells from the host tissues.

Janin-Mercier A; Valade S; Boccon-Gibbod L; D'Agay MF; Bourges M; Devergie A; Gluckman E

1985-01-01

222

99mTc-HDP Bone Scintigraphy Finding of Metastatic Renal Cell Carcinoma Bone Lesion Changed from Hot to Cold Lesion: Comparing with 18F-FDG PET/CT  

International Nuclear Information System (INIS)

A 26-year-old man with renal cell carcinoma underwent 99mTc-HDP bone scintigraphy for detecting bony metastasis after left total nephrectomy for renal cell carcinoma. 99mTc-HDP bone scintigraphy showed small hot lesion in the first lumbar spine. About 12 months later, he underwent spinal MRI for lower back pain. A large mass was seen around spinous process of the first lumbar spine (L1) on spinal MRI and confirmed as metastatic renal cell carcinoma by bone biopsy. 99mTc-HDP bone scintigraphy and 18F-FDG PET/CT were underwent for further evaluation. 99mTc-HDP bone scintigraphy showed cold lesion in the first lumbar spine which was initially hot and newly developed hot lesion in the twelfth thoracic spine, and which were shown as hypermetabolic lesions in 18F-FDG PET/CT. We report a case of bony metastasis from renal cell carcinoma which is changed from hot lesion to cold lesion in 99mTc-HDP bone scintigraphy and compare with 18F-FDG PET/CT

2009-01-01

223

{sup 99m}Tc-HDP Bone Scintigraphy Finding of Metastatic Renal Cell Carcinoma Bone Lesion Changed from Hot to Cold Lesion: Comparing with {sup 18}F-FDG PET/CT  

Energy Technology Data Exchange (ETDEWEB)

A 26-year-old man with renal cell carcinoma underwent {sup 99m}Tc-HDP bone scintigraphy for detecting bony metastasis after left total nephrectomy for renal cell carcinoma. {sup 99m}Tc-HDP bone scintigraphy showed small hot lesion in the first lumbar spine. About 12 months later, he underwent spinal MRI for lower back pain. A large mass was seen around spinous process of the first lumbar spine (L1) on spinal MRI and confirmed as metastatic renal cell carcinoma by bone biopsy. {sup 99m}Tc-HDP bone scintigraphy and {sup 18}F-FDG PET/CT were underwent for further evaluation. {sup 99m}Tc-HDP bone scintigraphy showed cold lesion in the first lumbar spine which was initially hot and newly developed hot lesion in the twelfth thoracic spine, and which were shown as hypermetabolic lesions in {sup 18}F-FDG PET/CT. We report a case of bony metastasis from renal cell carcinoma which is changed from hot lesion to cold lesion in {sup 99m}Tc-HDP bone scintigraphy and compare with {sup 18}F-FDG PET/CT.

Seo, Young Duk; Kim, Seong Min; Kim, Kun Ho [Chungnam National University Hospital, Daejeon (Korea, Republic of)

2009-12-15

224

The effect of a Hill-Sachs defect on glenohumeral translations, in situ capsular forces, and bony contact forces.  

UK PubMed Central (United Kingdom)

BACKGROUND: Hill-Sachs defects have been associated with failed repairs for anterior shoulder instability. However, the biomechanical consequences of these defects are not well understood because of the complicated interaction between the passive soft tissue and bony stabilizers. HYPOTHESIS: The creation of a 25% Hill-Sachs defect would not significantly alter the glenohumeral translations but would increase the in situ forces in the glenohumeral capsule as well as the glenohumeral bony contact forces. STUDY DESIGN: Controlled laboratory study. METHODS: A robotic/universal force-moment sensor (UFS) testing system was used to apply joint compression (22 N) and an anterior or posterior load (44 N) to cadaveric shoulders (n = 9) with the skin and deltoid removed (intact) at 3 glenohumeral joint positions (abduction/external rotation): 0°/0°, 30°/30°, and 60°/60° (corresponds to 90°/90° of shoulder abduction/external rotation). A 25% bony defect on the posterolateral humeral head (defect) was then created in the most common position of anterior shoulder dislocation (90°/90°), and the loading protocol was repeated. A nonparametric repeated-measures Friedman test with a Wilcoxon signed-rank post hoc test was performed to compare translations, in situ forces in the capsule, and bony contact forces between each state (P < .05). RESULTS: At 0°/0°, anterior translation significantly increased from 15.3 ± 8.2 mm to 16.6 ± 9.0 mm (P < .05) in response to an anterior load. At 30°/30°, anterior and posterior translations, respectively, significantly increased in response to both anterior (intact: 13.6 ± 7.1 mm vs defect: 14.2 ± 7 mm; P < .05) and posterior loads (intact: 15.7 ± 5.8 mm vs defect: 17.7 ± 5.1 mm; P < .05). In situ force in the capsule during anterior loading was increased in the defect state at both 60°/60° (intact: 38.9 ± 14.4 N vs defect: 43.2 ± 15.9 N; P < .05) and 30°/30° (intact: 39.6 ± 13.8 N vs defect: 45.6 ± 9.3 N; P < .05). The medial bony contact forces were also increased in the defect state at 30°/30° (intact: 25.0 ± 13.8 N vs defect: 28.9 ± 13.2 N; P < .05) during anterior loading. CONCLUSION: We believe that the stabilizing function of the intact capsule was the primary contributor to the finding of only small increases of anterior translation, capsule forces, and bony contact forces observed with a 25% Hill-Sachs defect in response to an anterior load. CLINICAL RELEVANCE: These findings imply that a 25% Hill-Sachs defect in isolation may not be responsible for recurrent instability if the function of the capsule is restored to the intact state and that the presence of the Hill-Sachs defect may be a marker for significant concomitant injury to the anterior glenoid rim. However, the small changes in these parameters may have long-term implications for the development of osteoarthritis.

Sekiya JK; Jolly J; Debski RE

2012-02-01

225

Alveolar bony crest preservation at implants installed immediately after tooth extraction: an experimental study in the dog.  

UK PubMed Central (United Kingdom)

AIM: To evaluate the influence of deproteinized bovine bone mineral in conjunction with a collagen membrane, at implants installed into sockets in a lingual position immediately after tooth extraction, and presenting initial horizontal residual buccal defects <2 mm. MATERIAL AND METHODS: The pulp tissue of the mesial roots of (4)P(4) was removed in six Labrador dogs, and the root canals were filled with gutta-percha and cement. Flaps were elevated, and the buccal and lingual alveolar bony plates were exposed. The premolars were hemi-sectioned, and the distal roots were removed. Implants were installed in a lingual position and with the margin flush with the buccal bony crest. After installation, defects resulted at about 1.7 mm in width at the buccal aspects, both at the test and control sites. Only in the left site (test), deproteinized bovine bone mineral (DBBM) particles were placed into the defect concomitantly with the placement of a collagen membrane. A non-submerged healing was allowed. RESULTS: After 3 months of healing, one implant was found not integrated and was excluded from the analysis together with the contralateral control implant. All remaining implants were integrated into mature bone. The bony crest was located at the same level of the implant shoulder, both at the test and control sites. At the buccal aspect, the most coronal bone-to-implant contact was located at a similar distance from the implant margin at the test (1.7 ± 1.0 mm) and control (1.6 ± 0.8 mm) sites, respectively. Only small residual DBBM particles were found at the test sites. CONCLUSION: The placement of an implant in a lingual position into a socket immediately after tooth extraction may favor a low exposure of the buccal implant surface. The use of DBBM particles, concomitantly with a collagen membrane, did not additionally improve the outcome obtained at the control sites.

Favero G; Botticelli D; Favero G; García B; Mainetti T; Lang NP

2013-01-01

226

Distance-to-agreement investigation of Tomotherapy's bony anatomy-based autoregistration and planning target volume contour-based optimization.  

UK PubMed Central (United Kingdom)

PURPOSE: To compare Tomotherapy's megavoltage computed tomography bony anatomy autoregistration with the best achievable registration, assuming no deformation and perfect knowledge of planning target volume (PTV) location. METHODS AND MATERIALS: Distance-to-agreement (DTA) of the PTV was determined by applying a rigid-body shift to the PTV region of interest of the prostate from its reference position, assuming no deformations. Planning target volume region of interest of the prostate was extracted from the patient archives. The reference position was set by the 6 degrees of freedom (dof)-x, y, z, roll, pitch, and yaw-optimization results from the previous study at this institution. The DTA and the compensating parameters were calculated by the shift of the PTV from the reference 6-dof to the 4-dof-x, y, z, and roll-optimization. In this study, the effectiveness of Tomotherapy's 4-dof bony anatomy-based autoregistration was compared with the idealized 4-dof PTV contour-based optimization. RESULTS: The maximum DTA (maxDTA) of the bony anatomy-based autoregistration was 3.2 ± 1.9 mm, with the maximum value of 8.0 mm. The maxDTA of the contour-based optimization was 1.8 ± 1.3 mm, with the maximum value of 5.7 mm. Comparison of Pearson correlation of the compensating parameters between the 2 4-dof optimization algorithms shows that there is a small but statistically significant correlation in y and z (0.236 and 0.300, respectively), whereas there is very weak correlation in x and roll (0.062 and 0.025, respectively). CONCLUSIONS: We find that there is an average improvement of approximately 1 mm in terms of maxDTA on the PTV going from 4-dof bony anatomy-based autoregistration to the 4-dof contour-based optimization. Pearson correlation analysis of the 2 4-dof optimizations suggests that uncertainties due to deformation and inadequate resolution account for much of the compensating parameters, but pitch variation also makes a statistically significant contribution.

Suh S; Schultheiss TE

2013-03-01

227

Intraosseous hemangioma as a rare differential diagnosis of intranasal bony tumor.  

UK PubMed Central (United Kingdom)

Intraosseous hemangioma is a benign vascular tumor of the bone. The most common site of this tumor is the vertebral body, followed by calvarial bones. Intraosseous hemangioma of the nasal cavity is extremely rare. This lesion had en bloc been resected through the endoscopic approach without preoperative embolization, significant intraoperative bleeding, and postoperative events. We report a rare case of intraosseous hemangioma of the nasal cavity with distinctive radiologic findings. Clinicians should be well familiar with the radiologic findings and clinical features of this tumor, which would be helpful in making a correct diagnosis and management plan.

Kim JH; Park HS; Kang JW

2013-07-01

228

Intraosseous hemangioma as a rare differential diagnosis of intranasal bony tumor.  

Science.gov (United States)

Intraosseous hemangioma is a benign vascular tumor of the bone. The most common site of this tumor is the vertebral body, followed by calvarial bones. Intraosseous hemangioma of the nasal cavity is extremely rare. This lesion had en bloc been resected through the endoscopic approach without preoperative embolization, significant intraoperative bleeding, and postoperative events. We report a rare case of intraosseous hemangioma of the nasal cavity with distinctive radiologic findings. Clinicians should be well familiar with the radiologic findings and clinical features of this tumor, which would be helpful in making a correct diagnosis and management plan. PMID:23851855

Kim, Jeong Hong; Park, Heae Surng; Kang, Ju Wan

2013-07-01

229

Sinonasal fibro-osseous hamartoma: case presentation and differential diagnosis with other fibro-osseous lesions involving the paranasal sinuses.  

UK PubMed Central (United Kingdom)

We present the case of a 2-year-old girl who was referred to the ENT Department of the Antwerp University with a bony obstruction of the left side of the nose. The lesion originated from the ethmoid roof and the middle turbinate and extended into the nasopharynx. A partial functional resection was performed using an endoscopic approach. A combination of clinical, radiographic and histological information permitted a diagnosis of a benign fibro-osseous lesion: sinonasal hamartoma. The benign nature of this tumor justified a conservative follow-up.

Boudewyns AN; van Dinther JJ; Colpaert CG

2006-03-01

230

Sinonasal fibro-osseous hamartoma: case presentation and differential diagnosis with other fibro-osseous lesions involving the paranasal sinuses.  

Science.gov (United States)

We present the case of a 2-year-old girl who was referred to the ENT Department of the Antwerp University with a bony obstruction of the left side of the nose. The lesion originated from the ethmoid roof and the middle turbinate and extended into the nasopharynx. A partial functional resection was performed using an endoscopic approach. A combination of clinical, radiographic and histological information permitted a diagnosis of a benign fibro-osseous lesion: sinonasal hamartoma. The benign nature of this tumor justified a conservative follow-up. PMID:16283200

Boudewyns, A N; van Dinther, J J S; Colpaert, C G

2005-11-09

231

Bony pathologies of the metacarpophalangeal joints in early rheumatoid arthritis. Comparison of MRI and high-resolution SPECT  

International Nuclear Information System (INIS)

Aim: comparison of MRI with a newly developed high-resolution multi-pinhole single photon emission computed tomography (MPH-SPECT) regarding the detection of bony pathologies of the metacarpophalangeal (MCP) joints in patients with early rheumatoid arthritis (ERA). Materials and methods: the clinically dominant hand of 15 patients with ERA (disease duration 6 months) was examined using MRI and MPH-SPECT. The evaluation of MRI was achieved according to RAMRIS criteria and for the MPH SPECT regarding pathological tracer uptake and distribution. Image fusions of MRI and MPH-SPECT were provided and the two methods were compared. Results: in MRI 12 of 15 patients showed arthritic joint pathologies, while 8 patients exhibited soft tissue and bony changes. 4 patients had only soft tissue inflammation (synovitis) with a normal bone signal. In MPH-SPECT 10 of 15 patients showed pathologically increased bone metabolism. The fusion images presented a high agreement of the pathological changes in both methods, while areas with increased bone metabolism were not only present in the case of erosions, but also in the case of bone edema. In 2 patients increased bone metabolism was detectable in areas of MR tomographic normal bone, while a clear surrounding synovitis was present in each case here. (orig.)

2009-01-01

232

Thoracic hyperextension injury with complete “bony disruption” of the thoracic cage: Case report of a potentially life-threatening injury  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Severe chest wall injuries are potentially life-threatening injuries which require a standardized multidisciplinary management strategy for prevention of posttraumatic complications and adverse outcome. Case presentation We report the successful management of a 55-year old man who sustained a complete “bony disruption” of the thoracic cage secondary to an “all-terrain vehicle” roll-over accident. The injury pattern consisted of a bilateral “flail chest” with serial segmental rib fractures, bilateral hemo-pneumothoraces and pulmonary contusions, bilateral midshaft clavicle fractures, a displaced transverse sternum fracture with significant diastasis, and an unstable T9 hyperextension injury. After initial life-saving procedures, the chest wall injuries were sequentially stabilized by surgical fixation of bilateral clavicle fractures, locked plating of the displaced sternal fracture, and a two-level anterior spine fixation of the T9 hyperextension injury. The patient had an excellent radiological and physiological outcome at 6?months post injury. Conclusion Severe chest wall trauma with a complete “bony disruption” of the thoracic cage represents a rare, but detrimental injury pattern. Multidisciplinary management with a staged timing for addressing each of the critical injuries, represents the ideal approach for an excellent long-term outcome.

Bailey James; VanderHeiden Todd; Burlew Clay; Pinski-Sibbel Sarah; Jordan Janeen; Moore Ernest E; Stahel Philip F

2012-01-01

233

Ancient earthen constructions and antiseismic dwellings: Boni's project after the earthquake of 13th January 1915 (Avezzano, Italy)  

Directory of Open Access Journals (Sweden)

Full Text Available After the earthquake of 13th January 1915, the archaeologist Giacomo Boni (1859-1925), inspired by ancient building techniques. proposed the reconstruction of Marsica and the Middle Liri Valley with earthen dwellings. With the cooperation of the Italian Ministry of Agriculture, he organized an exhibition where he collected samples of vegetal trellises which were an essential support to implement these techniques. Furthermore, he rebuilt two huts on the Palatine (Orti Farnesiani): one rectangular, the other circular, inspired by terracotta urns which he himself had discovered a few years earlier exploring the famous ancient tombs in the Forum Romanum, near the temple of Antonino and Faustina, by the Via Sacra. Boni's unusual proposal was intended as an alternative to the plans put forward by seismic engineering which was developing in Italy at that time. This is a prime example of a clash between two different outlooks and cultures (humanism versus science) each of which claimed to offer solutions to attenuate the effect of earthquakes. We have so far been unable to establish whether any earthen dwellings were actually constructed in Marsica or the surroundings of Sora for the survivors of the earthquake of 13th January 1915. Unfortunately, only one of the many houses built with this technique. still existing in the Soran countryside can be dated (1924).

E. M. Beranger

1995-01-01

234

MRI of degenerative bone marrow lesions in experimental osteoarthritis of canine knee joints  

Energy Technology Data Exchange (ETDEWEB)

Objective. The objective of this study was to determine the value of MRI in the detection of degenerative bone marrow abnormalities in an animal osteoarthritis model. Design. In 10 dogs with experimentally induced unilateral osteoarthritis of the knee, MRI was performed using two-dimensional spin-echo (2D-SE) and three-dimensional gradient-echo (3D-GE) imaging. Contrast enhanced T1-weighted 2D-SE sequences were also obtained after injection of gadolinium-DTPA. The results were compared with the gross and histopathologic findings and with radiography. Results. Histopathologic specimens revealed 21 osteosclerotic lesions and 5 intraosseous cysts. On 2D-SE images, 24 of 26 lesions were detected, while 21 of 26 lesions were identified on 2D-GE sequences. Radiography, including conventional tomography, demonstrated 9 of 26 lesions. Regardless of the sequence weighting, all osteosclerotic lesions appeared hypointense on MRI. Signal loss in bone sclerosis resulted primarily from the reduction of intact fat marrow, the increased bone density being of secondary importance. Quantitative signal analysis allowed approximate estimation of the grade of sclerosis. On postcontrast images, sclerotic bone remained hypointense, although significant but non-specific enhancement relative to the normal fat marrow was observed. The extent of contrast enhancement did not correlate with the grade of osteosclerosis. All five cysts were readily diagnosed by MRI. Cysts displayed either central or marginal contrast enhancement within their cavities. Conclusions. MRI provides a sensitive method for the diagnosis of osteoarthritic bone abnormalities, allowing their differentiation from most non-degenerative subarticular lesions. (orig.). With 1 tab.

Nolte-Ernsting, C.C.A. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany); Adam, G. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany); Buehne, M. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany); Prescher, A. [Department of Anatomy, University of Technology, Aachen (Germany); Guenther, R.W. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany)

1996-07-01

235

Central giant cell lesion.  

UK PubMed Central (United Kingdom)

A classic case of central giant cell lesion (CGCL) is presented with emphasis on clinical, radiologic, and histologic features. The differential is discussed including peripheral giant cell granuloma, brown tumor of hyperparathyroidism, and giant cell tumor of bone. The molecular pathway of osteoclastogenesis is selectively reviewed and applied to suggest possible etiologies of the giant cell lesions. CGCL syndromes and treatment are also discussed.

Valentine JC; Nelson BL

2011-12-01

236

Noninfectious penile lesions.  

UK PubMed Central (United Kingdom)

Family physicians commonly diagnose and manage penile cutaneous lesions. Noninfectious lesions may be classified as inflammatory and papulosquamous (e.g., psoriasis, lichen sclerosus, angiokeratomas, lichen nitidus, lichen planus), or as neoplastic (e.g., carcinoma in situ, invasive squamous cell carcinoma). The clinical presentation and appearance of the lesions guide the diagnosis. Psoriasis presents as red or salmon-colored plaques with overlying scales, often with systemic lesions. Lichen sclerosus presents as a phimotic, hypopigmented prepuce or glans penis with a cellophane-like texture. Angiokeratomas are typically asymptomatic, well-circumscribed, red or blue papules, whereas lichen nitidus usually produces asymptomatic pinhead-sized, hypopigmented papules. The lesions of lichen planus are pruritic, violaceous, polygonal papules that are typically systemic. Carcinoma in situ should be suspected if the patient has velvety red or keratotic plaques of the glans penis or prepuce, whereas invasive squamous cell carcinoma presents as a painless lump, ulcer, or fungating irregular mass. Some benign lesions, such as psoriasis and lichen planus, can mimic carcinoma in situ or squamous cell carcinoma. Biopsy is indicated if the diagnosis is in doubt or neoplasm cannot be excluded. The management of benign penile lesions usually involves observation or topical corticosteroids; however, neoplastic lesions generally require surgery.

Teichman JM; Sea J; Thompson IM; Elston DM

2010-01-01

237

Radiographic evaluation of the Hill-Sachs lesion in patients with recurrent anterior shoulder instability.  

UK PubMed Central (United Kingdom)

The Hill-Sachs lesion is an important bony sign of previous anterior shoulder dislocation and instability. Using orthographic projection, we evaluated the Hill-Sachs lesion in 30 shoulders in 27 patients with recurrent anterior shoulder instability. This produced a clear and undistorted view of the posterolateral notch. For orthographic imaging, the patient was placed supine with the arm in 135 degrees of flexion and 15 degrees of internal rotation. The x-ray beam was angled vertically through the humeral head. The width and depth of the posterolateral notches were measured on the orthographic radiographs. The average posterolateral notch depths were 3.9 +/- 0.9 mm in the dislocation group and 2.1 +/- 1.0 mm in the subluxation group. A shallow Hill-Sachs lesion was indicative of a greater degree of anterior instability of the shoulder.

Ito H; Takayama A; Shirai Y

2000-11-01

238

Tumor and tumor-like lesion of jaw bone: CT findings and clinical applications  

International Nuclear Information System (INIS)

Objective: To evaluate the CT findings and clinical applications in Jaw bone tumor and tumor-like lesions. Methods: CT appearances of 36 patients with Jaw bone tumor proved by surgery and pathology were reviewed. Results: One osteosarcoma showed irregular soft-tissue mass with osteolytic bone destruction and new tumor bone formation. Six cases of benign tumor or tumor-like lesions showed masses with regular margin, without calcification, new tumor bone formation and periosteal reaction. Six cases of ameloblastoma showed regular margin masses with multilocular and bone expansion. The multiple bone expansion and interspersed bony trabeculae were found in 2 cases of fibrous hyperplasia of bone. Conclusion: Various jaw bone tumor and tumor-like lesions demonstrated different CT features. CT scan was one of important examination methods for diagnosis and extent evaluations. (authors)

2007-01-01

239

Clinical investigation of metastatic bony pain treated by 153Sm-EDTMP  

International Nuclear Information System (INIS)

Samarium-153-ethylenediamine tetramethylene phosphonic acid (EDTMP), a bone-seeking radiopharmaceutical, was given to treat patients with disseminated bone metastases. A total of fifty patients, 26 male and 24 female, 44 metastatic and 6 primary bone tumor were treated with a single dose of 1480 MBq. Some of them had 153Sm-EDTMP whole-body bone scans 48 hours after 153Sm-EDTMP, and their lesion-to normal ratios of bone were calculated. Overall alleviation of pain with 153Sm-EDTMP was 76% (38/50) and 24% of the patients were completely relief from pain. Pain relief sustained from 4 to 8 weeks in 60% of patients. It was suggested that this new therapeutic agent may have a potential benefit for the diagnosis and management of disseminated metastatic bone carcinomas

1995-01-01

240

The Management of Metastatic Thyroid Carcinoma: An Initial Presentation with Bony Metastasis  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Metastatic thyroid carcinoma presenting at the initial time of diagnosis is uncommon and the prognosis is unclear. Long term survival rates are variable ranging from 13% to 100%. This case report is presented to illustrate potential management and lend statistical power to future analysis of the correct treatment planning, mortality rates, and prognostic indications for an uncommon presentation of thyroid cancer. Case presentation: This patient is a 63 year old female who presented with new onset of progressive right hip pain. She was treated with a cortisone injection for presumed osteoarthritis but did not improve. Physical exam at the time was pertinent for a body mass index (BMI) of 38.4, mild systolic hypertension, difficulty walking secondary to the right hip pain, limited range of motion at the hip, and fullness of right thyroid gland with no palpable nodules. Laboratory evaluation including thyroid function tests was normal. However, CT and MRI scans revealed a 6.5 cm × 5 cm osteolytic expansive lesion on the right iliac crest with a soft tissue mass. In addition, an enlarged right thyroid lobe and small nodular densities in the lungs suspicious for metastatic disease were noted. A fine needle aspiration of the right ileum revealed metastatic follicular adenocarcinoma consistent with a thyroid primary. The patient was not a surgical candidate due to the extent of disease. She received 37.5 Gy to both the right iliac crest mass and the neck to include the thyroid lesion, followed by iodine-131 ablation and bisphosphonate therapy. Her disease was stable on her last follow up at 48 months. Conclusion: Further studies identifying independent variables such as age of the patient, site and extent of the disease and histology of the tumor are needed to help determine the true prognosis and proper management patients with this presentation. The optimal treatment with potential chance for cure in patients with metastatic thyroid carcinoma has yet to be elucidated.

Tony Y. Eng; Samantha Litchke; Aidnag Z. Diaz; Join Y. Luh

2011-01-01

 
 
 
 
241

Influence of rotational setup error on tumor shift in bony anatomy matching measured with pulmonary point registration in stereotactic body radiotherapy for early lung cancer  

International Nuclear Information System (INIS)

The objective of this study was to examine the correlation between the patient rotational error measured with pulmonary point registration and tumor shift after bony anatomy matching in stereotactic body radiotherapy for lung cancer. Twenty-six patients with lung cancer who underwent stereotactic body radiotherapy were the subjects. On 104 cone-beam computed tomography measurements performed prior to radiation delivery, rotational setup errors were measured with point registration using pulmonary structures. Translational registration using bony anatomy matching was done and the three-dimensional vector of tumor displacement was measured retrospectively. Correlation among the three-dimensional vector and rotational error and vertebra-tumor distance was investigated quantitatively. The median and maximum rotational errors of the roll, pitch and yaw were 0.8, 0.9 and 0.5, and 6.0, 4.5 and 2.5, respectively. Bony anatomy matching resulted in a 0.2-1.6 cm three-dimensional vector of tumor shift. The shift became larger as the vertebra-tumor distance increased. Multiple regression analysis for the three-dimensional vector indicated that in the case of bony anatomy matching, tumor shifts of 5 and 10 mm were expected for vertebra-tumor distances of 4.46 and 14.1 cm, respectively. Using pulmonary point registration, it was found that the rotational setup error influences the tumor shift. Bony anatomy matching is not appropriate for hypofractionated stereotactic body radiotherapy with a tight margin. (author)

2012-01-01

242

Ocena ilo?ciowa wybranych komórek b?ony ?luzowej ?o??dka i dwunastnicy u dzieci z nadwra?liwo?ci? pokarmow?, infekcj? Helicobacter pylori i giardiaz?  

Directory of Open Access Journals (Sweden)

Full Text Available Sta?y kontakt przewodu pokarmowego z antygenami pokarmowymi oraz czynnikami infekcyjnymi natury bakteryjnej (np. H. pylori) czy paso?ytniczej (np. Giardia lamblia) prowadzi? mo?e w efekcie ko?cowym do stanu zapalnego b?ony ?luzowej. W proces ten zostaje zaanga?owanych wiele komórek o ró?nych funkcjach biologicznych np. neutrofile, eozynofile, limfocyty T i B, mastocyty, których aktywacja prowadzi do uwalniania wielu mediatorów biologicznych. Celem pracy by?a ocena nacieku komórkowego w b?onie ?luzowej ?o??dka i dwunastnicy u dzieci z nadwra?liwo?ci? pokarmow?, infekcj? H. pylori i giardiaz?. Uzyskane wyniki bada? morfologicznych b?ony ?luzowej ?o??dka i dwunastnicy wykaza?y, i? zmiany zapalne w przewlek?ym zapaleniu b?ony ?luzowej ?o??dka i dwunastnicy u dzieci w wieku przedszkolnym i szkolnym s? zró?nicowane co do aktywno?ci zapalenia mierzonej ilo?ci? naciekaj?cych granulocytów. W nadwra?liwo?ci pokarmowej aktywno?? zapalenia ma?? i ?redni? stwierdzono ??cznie u 14,5% badanych w trzonie; u 20,7% w antrum. W zaka?eniu H. pylori zarówno w antrum i trzonie dominowa?a aktywno?? ci??ka i ?rednia. Równoczasowo u wybranej grupy chorych wykonane badania immunohistochemiczne wykaza?y zwi?kszony naciek z limfocytów T i B, eozynofili i mastocytów w obr?bie b?ony ?luzowej ?o??dka i/lub dwunastnicy niezale?nie od ustalonej przyczyny stanu zapalnego.

El?bieta Maciorkowska; Maciej Kaczmarski; Katarzyna Kondej-Muszy?ska; Andrzej Kemona; Izabela Roszko; Justyna Cie?la

2002-01-01

243

Reversible focal splenial lesions  

Energy Technology Data Exchange (ETDEWEB)

Reversible focal lesions in the splenium of the corpus callosum (SCC) have recently been reported.They are circumscribed and located in the median aspect of the SCC. On MRI, they are hyperintense on T2-W and iso-hypointense on T1-W sequences, with no contrast enhancement. On DWI, SCC lesions are hyperintense with low ADC values, reflecting restricted diffusion due to cytotoxic edema. The common element is the disappearance of imaging abnormalities with time, including normalization of DWI. Clinical improvement is often reported. The most established and frequent causes of reversible focal lesions of the SCC are viral encephalitis, antiepileptic drug toxicity/withdrawal and hypoglycemic encephalopathy. Many other causes have been reported, including traumatic axonal injury. The similar clinical and imaging features suggest a common mechanism induced by different pathological events leading to the same results. Edema and diffusion restriction in focal reversible lesions of the SCC have been attributed to excitotoxic mechanisms that can result from different mechanisms; no unifying relationship has been found to explain all the pathologies associated with SCC lesions. In our opinion, the similar imaging, clinical and prognostic aspects of these lesions depend on a high vulnerability of the SCC to excitotoxic edema and are less dependent on the underlying pathology. In this review, the relevant literature concerning reversible focal lesions in the SCC is analyzed and hypotheses about their pathogenesis are proposed. (orig.)

Gallucci, Massimo; Limbucci, Nicola [University of L' Aquila, Department of Radiology, S. Salvatore Hospital, L' Aquila (Italy); Paonessa, Amalia [Loreto Nuovo Hospital, Department of Neuroradiology, Napoli (Italy); Caranci, Ferdinando [Federico II University, Department of Neurological Sciences, Napoli (Italy)

2007-07-15

244

Intraosseous osteolytic lesions  

International Nuclear Information System (INIS)

Any pathological damage occurring in a bone will produce either an osteolytic or osteosclerotic lesion which can be seen in the macroscopic specimen as well as in the roentgenogram. Various bone lesions may lead to local destructions of the bone. An osteoma or osteoplastic osteosarcoma produces an osteosclerotic lesion showing a dense mass in the roentgenogram; a chondroblastoma or an osteoclastoma, on the other hand, induces an osteolytic focal lesion. This paper presents examples of different osteolytic lesions of the humerus. An osteolytic lesion seen in the roentgenogram may be either produced by an underlying non-ossifying fibroma of the bone, by fibrous dysplasia, osteomyelitis or Ewing's sarcoma. Differential diagnostic considerations based on the radiological picture include eosinophilic bone granuloma, juvenile or aneurysmal bone cyst, multiple myeloma or bone metastases. Serious differential diagnostic problems may be involved in case of osteolytic lesions occurring in the humerus. Cases of this type involving complications have been reported and include the presence of an teleangiectatic osteosarcoma as well as that of a hemangiosarcoma of the bone. (orig.).

1981-01-01

245

131?Pediatric skull lesions.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Palpable skull lesions encompass a diverse group of histological entities. A review of these masses at 1 institution was undertaken for further insights. METHODS: An IRB approved retrospective review was undertaken to identify all patients who underwent surgical excision of a skull mass between 1997 & 2012. RESULTS: A total of 279 patients were identified, with no sex predilection (Male: 140, Female: 139). Non-malignant lesions totaled 264/279 (95%) with dermoid cysts 142 (52%) and Langerhan Cell Histiocytosis (LCH) 31 (11%) being the most common. Malignant lesions accounted for 15/279 (5%) and consisted of 4 primary malignancies and 11 metastatic lesions and included a diverse histology. Pain to palpation was noted in 38/279 (14%), 35 of which were benign with LCH accounting for 17. Mean age at diagnosis for malignant lesions was not significantly different from those non-malignant (59 and 69 months, respectively; P = .1). No significant complication from the surgery was recorded in any patient. At a mean follow-up interval of 17 months, recurrence was encountered in 8/15 malignant lesions and 5/264 benign masses, usually at the original site. Only 42/279 (15%) had some form of preoperative imaging. CONCLUSION: The overwhelming majority of skull masses can be completely and safely excised with preoperative imaging not needed for obvious lesions such as dermoid cysts.

Jeelani Y; Da Silva SL; Young GJ; Krieger MD; McComb JG

2013-08-01

246

Rola aktywnych form azotu i tlenu w zanikowym zapaleniu b?ony ?luzowej ?o??dka u dzieci  

Directory of Open Access Journals (Sweden)

Full Text Available Cel pracy: Ocena st??enia tlenku azotu, dialdehydu malonowego i nadtlenku wodoru jako wyk?adników aktywnych form azotu i tlenu u dzieci z zanikowym zapaleniem b?ony ?luzowej ?o??dka. Materia? i metody: Badania przeprowadzono w pi?ciu grupach dzieci z przewlek?ym zanikowym zapaleniem b?ony ?luzowej ?o??dka (chroni? atrophic gastritis - CAG) z zaka?eniem Helicobacter pylori (H. pylori), nadwra?liwo?ci? pokarmow?, bez udokumentowanej przyczyny oraz grupie kontrolnej. Gastroskopi? z pobraniem wycinków oraz oznaczenia we krwi st??enia tlenku azotu (nitric oxide - NO), dialdehydu malonowego (malonyldialdehyde - MDA) oraz nadtlenku wodoru (H202) wykonywano przed rozpocz?ciem leczenia (D-0) oraz 6 tygodni po jego zako?czeniu (D-50). NO w surowicy krwi oznaczano zestawami testowymi firmy Oxis, st??enie MDA metod? Ohkawy, a H202 metod? enzymatyczno-kolorymetryczn?. Wyniki: Przed leczeniem stwierdzono wysokie st??enia NO w porównaniu z grup? kontroln? (p<0,0001), które korelowa?y ze stopniem zaniku (im wy?szy stopie? zaniku, tym wy?sze st??enie NO) i stopniem zaka?enia H. pylori. U wszystkich badanych, przed leczeniem, niezale?nie od stopnia zaniku i zaka?enia H. pylori, stwierdzono istotnie statystycznie wysokie st??enia MDA w porównaniu z grup? kontroln? (x=24,3±4,6 nmol/l). 4--krotnie wy?sze st??enie H202 w porównaniu do grupy kontrolnej przed leczeniem spostrzegano u dzieci z zaka?eniem H. pylori i nadwra?liwo?ci? pokarmow? (x=28,3±8,0 uM) i 3-krotnie wy?sze u dzieci z zaka?eniem H. pylori. W modelu log-liniowym analizowane zale?no?ci s? istotne statystycznie (<0,0001) w uk?adach MDA vs NO, H202 vs NO. Wnioski: Wykazano, ?e w przewlek?y zanikowy proces zapalny b?ony ?luzowej ?o??dka zaanga?owane s? mediatory biochemiczne, a zaka?enie H. pylori mo?e inicjowa? i podtrzymywa? zapalenie.

Iwona Igny?; Hanna Krauss; Beata Klincewicz; Wojciech Cichy

2006-01-01

247

Skin lesions in histoplasmosis.  

UK PubMed Central (United Kingdom)

Histoplasmosis is a granulomatous infection caused by Histoplasma capsulatum, a dimorphic fungus. It is distributed worldwide and prevalent in certain regions of North and Central America. Pulmonary involvement is the most common clinical presentation. Cutaneous manifestations are reported to occur in 10% to 25% of AIDS patients with disseminated histoplasmosis. The skin lesions are polymorphic papules, plaques with or without crusts, pustules, nodules, mucosal ulcers, erosions, punched out ulcers, lesions resembling molluscum contagiosum, acneiform eruptions, erythematosus papules and keratotic plaques, purpuric lesions, and localized and generalized vegetant forms of dermatitis, sometimes an eruption similar to rosacea, keratotic papules with transepidermal elimination, polymorphous erythema, erythroderma syndromes, pyoderma gangrenosum, panniculitis, diffuse hyperpigmentation, abscesses, and cellulitis.

Chang P; Rodas C

2012-11-01

248

[High prevalence of antiHTLV-1 antibodies in the Boni, an ethnic group of African origin isolated in French Guiana since the 18th century  

UK PubMed Central (United Kingdom)

Antibodies to HTLV-1 (ELISA test using disrupted virus) were studied in different ethnic groups in French Guiana, including 135 blood donors from Cayenne, 97 Boni Blacks and 57 Wayana Indians from Maripasoula area, and 57 Hmong from Cacao village. We observed significant differences between Boni Blacks and Wayana Indians, having respectively 10.3% versus 0% of high antibody titers. The Hmong, recent refugees from Kampuchea, exhibited an intermediate level (3.5%) of infection. These results favour an African origin of HTLV-1 and raise, for the Hmong, the question of an infection acquired in Guiana.

Gessain A; Calender A; Strobel M; Lefait-Robin R; de Thé G

1984-01-01

249

[High prevalence of antiHTLV-1 antibodies in the Boni, an ethnic group of African origin isolated in French Guiana since the 18th century].  

Science.gov (United States)

Antibodies to HTLV-1 (ELISA test using disrupted virus) were studied in different ethnic groups in French Guiana, including 135 blood donors from Cayenne, 97 Boni Blacks and 57 Wayana Indians from Maripasoula area, and 57 Hmong from Cacao village. We observed significant differences between Boni Blacks and Wayana Indians, having respectively 10.3% versus 0% of high antibody titers. The Hmong, recent refugees from Kampuchea, exhibited an intermediate level (3.5%) of infection. These results favour an African origin of HTLV-1 and raise, for the Hmong, the question of an infection acquired in Guiana. PMID:6095973

Gessain, A; Calender, A; Strobel, M; Lefait-Robin, R; de Thé, G

1984-01-01

250

Successful treatment of a patient with chronic lymphocytic leukaemia (CLL) presenting with bony metastases with aggressive antibody and chemotherapy.  

Science.gov (United States)

Osteolytic lesions are rare in chronic lymphocytic leukaemia (CLL) and thought to result from Richter's transformation or metastatic disease from nonlymphoid malignancies. We report a patient who presented with a large femoral metastatic lesion and hypercalcaemia caused by CLL itself. Complete remission of CLL with resolution of the osteolytic lesion was achieved with rituximab and cyclophosphamide, adriamycin, oncovin and prednisolone [CHOP (R-CHOP)] combination chemotherapy. PMID:16307545

Narayan, H; Bandyopadhyay, D; Schmidt, K; Chachlani, N; Hughes, M; Paneesha, S; Rose, P; Borg, A

2005-12-01

251

Successful treatment of a patient with chronic lymphocytic leukaemia (CLL) presenting with bony metastases with aggressive antibody and chemotherapy.  

UK PubMed Central (United Kingdom)

Osteolytic lesions are rare in chronic lymphocytic leukaemia (CLL) and thought to result from Richter's transformation or metastatic disease from nonlymphoid malignancies. We report a patient who presented with a large femoral metastatic lesion and hypercalcaemia caused by CLL itself. Complete remission of CLL with resolution of the osteolytic lesion was achieved with rituximab and cyclophosphamide, adriamycin, oncovin and prednisolone [CHOP (R-CHOP)] combination chemotherapy.

Narayan H; Bandyopadhyay D; Schmidt K; Chachlani N; Hughes M; Paneesha S; Rose P; Borg A

2005-12-01

252

Tooth Abfraction Lesions  

Science.gov (United States)

Tooth Abfraction Lesions What Is It? Symptoms Diagnosis Expected Duration Prevention Treatment When To Call a Professional ... affect the enamel , the outer layer of the tooth. In severe cases, the dentin and cementum layers ...

253

Bony variations on coronary CT cuts of the paranasal sinuses. Knoecherne Variationen im koronaren Nasennebenhoehlen-CT  

Energy Technology Data Exchange (ETDEWEB)

Bony variations in the anterior ethmoids may, if severe, play an important role in the development of chronic sinusitis and present the surgeon with added risks during operation. We have, therefore, analysed 390 preoperative CT examinations of the sinuses performed in the coronary plane with respect to the frequency of bone variations. Concha bullosa, increased pneumatisation of the agger nasi, large ethmoidal bullae, Haller's cells and increased pneumatisation of the sphenoid were found with equal frequency in about 20%. The most common variants occurred in the uncinate process (31.5%), less common were paradoxical curve of the middle turbinates (13.3%) and very rare were Onodi cells (1.3%). (orig.)

Koesling, S. (Abt. Diagnostische Radiologie, Klinik fuer Radiologie, Univ. Leipzig (Germany)); Wagner, F. (Abt. Diagnostische Radiologie, Klinik fuer Radiologie, Univ. Leipzig (Germany)); Schulz, H.G. (Abt. Diagnostische Radiologie, Klinik fuer Radiologie, Univ. Leipzig (Germany)); Heywang-Koebrunner, S. (Abt. Diagnostische Radiologie, Klinik fuer Radiologie, Univ. Leipzig (Germany))

1993-12-01

254

Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions  

Energy Technology Data Exchange (ETDEWEB)

Aim: The aim of this study is to evaluate the value of the apparent diffusion coefficient (ADC) obtained in diffusion-weighted (DW) MR sequences for the differentiation between malignant and benign bone marrow lesions. Method: Forty-five patients with altered signal intensity vertebral bodies on conventional MR sequences were included. The cause of altered signal intensity was benign osteoporotic collapse in 16, acute neoplastic infiltration in 15, and infectious processes in 14; based on plain-film, CT, bone scintigraphy, conventional MR studies, biopsy or follow-up. All patients underwent isotropic DW MR images (multi-shot EPI, b values of 0 and 500 s/mm{sup 2}). Signal intensity at DW MR images was evaluated and ADC values were calculated and compared between malignancy, benign edema and infectious spondylitis. Results: Acute malignant fractures were hyperintense compared to normal vertebral bodies on the diffusion-weighted sequence, except in one patient with sclerotic metastases. Mean ADC value from benign edema (1.9 {+-} 0.39 x 10{sup -3} mm{sup 2}/s) was significantly (p < 0.0001) higher than untreated metastasic lesions (0.9 {+-} 1.3 x 10{sup -3} mm{sup 2}/s). Mean ADC value of infectious spondilytis (0.96 {+-} 0.49 x 10{sup -3} mm{sup 2}/s) was not statistically (p > 0.05) different from untreated metastasic lesions. ADC value was low (0.75 x 10{sup -3} mm{sup 2}/s) in one case of subacute benign fracture. Conclusions: ADC values are a useful complementary tool to characterize bone marrow lesions, in order to distinguish acute benign fractures from malignant or infectious bone lesions. However, ADC values are not valuable in order to differentiate malignancy from infection.

Balliu, E. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: eballiu@gmail.com; Vilanova, J.C. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: Kvilanova@comg.es; Pelaez, I. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: isapelaezrx@yahoo.es; Puig, J. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: jpuigalcantara@yahoo.es; Remollo, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sremollo@gmail.com; Barcelo, C. [Department of Computer Science and Applied Mathematics, University of Girona (Spain)], E-mail: carles.barcelo@udg.es; Barcelo, J. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: rmgirona@comg.es; Pedraza, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sapedraza@gmail.com

2009-03-15

255

Arthroscopic excision of posterior ankle bony impingement for early return to the field: short-term results.  

UK PubMed Central (United Kingdom)

BACKGROUND: We treated 12 cases of posterior ankle bony impingement in 12 athletes arthroscopically, and examined the operating methods, findings, and postoperative physical therapy and overall results. MATERIALS AND METHODS: The patients' average age was 21.4 years. The mean duration of postoperative followup was 33.8 months. A 2.7-mm, 30 degree arthroscope was inserted into the subtalar joint using posterolateral and accessory posterolateral portals. When the impinged fragment was visualized, it was carefully excised from the surrounding soft tissues. The operation was completed once the entire flexor hallucis longus tendon was seen. No cast immobilization was applied postoperatively, and physical therapy including limited weight bearing and range-of-motion exercises commenced within 24 hours after surgery. Beginning 3 weeks after surgery, the patients were permitted to gradually resume sports under the guidance of a physiotherapist. The AOFAS ankle-hindfoot score, the postoperative range of motion of the ankle and the time to recover were determined. RESULTS: The average postoperative AOFAS ankle-hindfoot score improved from 68.0 to 98.3 points. The mean preoperative range of motion of the ankle joint was improved from 59.2 degree to 68.4 degree. The average period to return to sports was 5.9 weeks. All patients reached full activity within 13 weeks after surgery. The surgical time ranged from 40 minutes to over 2 hours and was affected by the impingement condition. CONCLUSION: Arthroscopic treatment for posterior ankle bony impingement syndrome was minimally invasive and suitable for athletes who desire an early return to sports activity.

Noguchi H; Ishii Y; Takeda M; Hasegawa A; Monden S; Takagishi K

2010-05-01

256

Clinical Evaluation of Positioning Verification Using Digital Tomosynthesis and Bony Anatomy and Soft Tissues for Prostate Image-Guided Radiotherapy  

International Nuclear Information System (INIS)

[en] Purpose: To evaluate on-board digital tomosynthesis (DTS) for patient positioning vs. two-dimensional (2D) radiography and three-dimensional cone beam (CBCT). Methods and Materials: A total of 92 image sessions from 9 prostate cancer patients were analyzed. An on-board image set was registered to a corresponding reference image set. Four pairs of image sets were used: digitally reconstructed radiographs vs. on-board orthogonal paired radiographs for the 2D method, coronal-reference DTS vs. on-board coronal DTS for the coronal-DTS method, sagittal-reference DTS vs. on-board sagittal DTS for the sagittal-DTS method, and planning CT vs. CBCT for the CBCT method. The registration results were compared. Results: The systematic errors in all methods were o. When registering the bony anatomy, the mean vector difference was 0.21 ± 0.11 cm between 2D and CBCT, 0.11 ± 0.08 cm between CBCT and coronal DTS, and 0.14 ± 0.07 cm between CBCT and sagittal DTS. The correlation between CBCT to DTS was stronger (coefficient = 0.92-0.95) than the correlation between 2D and CBCT or DTS (coefficient = 0.81-0.83). When registering the soft tissue, the mean vector difference was 0.18 ± 0.11 cm between CBCT and coronal DTS and 0.29 ± 0.17 cm between CBCT and sagittal DTS. The correlation coefficient of CBCT to sagittal DTS and to coronal DTS was 0.84 and 0.92, respectively. Conclusion: DTS could provide equivalent results to CBCT when the bony anatomy is used as landmarks for prostate image-guided radiotherapy. For soft tissue-based positioning verification, coronal DTS produced equivalent results to CBCT, but sagittal DTS alone was insufficient. DTS could allow for comparable soft tissue-based target localization with faster scanning time and a lower imaging dose compared with CBCT

2009-01-01

257

Placement of an Intrathecal Catheter Through a Bony Fusion Mass Using 3D Image Guidance: A Case Report.  

UK PubMed Central (United Kingdom)

OBJECTIVE:: We describe the 3-dimensional (3D) image-guided placement technique for a lumbar intrathecal catheter through a dorsal fusion mass. This is the first time this technique has been reported. A patient with 6 prior spine surgeries and chronic pain syndrome presented with a challenging large dorsal fusion mass. The use of 3D cone beam computed tomography-based image guidance proved advantageous for the placement of an intrathecal drug delivery system (IDDS). METHOD:: Under general anesthesia, image guidance was accomplished with the Medtronic Stealth S7 image guidance system, used in conjunction with the O-ARM (Medtronic Inc.). Using an image-guided probe over the skin surface, we navigated the dorsal fusion mass to identify a thin area at the L4-L5 level. A small incision was made and the image-guided probe was used to target the selected thin area and drill an adequate opening in the fusion mass. We inserted a Tuohy needle through the bony defect for passage of the intrathecal catheter. We confirmed adequate catheter placement using free flowing cerebrospinal fluid and fluoroscopy. The remainder of the IDDS implant proceeded per routine. RESULTS:: The patient tolerated the procedure well and had no complications. The morphine IDDS improved his overall pain and function with minimal side effects. CONCLUSIONS:: This is the first case report using 3D cone beam computed tomography-based image guidance for the placement of an intrathecal catheter through a bony fusion mass. This technique appears to be a viable option for IDDS implantation in patients with difficult anatomy.

Candler SA; Osborne MD; Derr MJ; Nottmeier EW

2013-04-01

258

Oral lesions in leprosy  

Directory of Open Access Journals (Sweden)

Full Text Available BACKGROUND: Leprotic oral lesions are more common in the lepromatous form of leprosy, indicate a late manifestation, and have a great epidemiological importance as a source of infection. METHODS: Patients with leprosy were examined searching for oral lesions. Biopsies of the left buccal mucosa in all patients, and of oral lesions, were performed and were stained with H&E and Wade. RESULTS: Oral lesions were found in 26 patients, 11 lepromatous leprosy, 14 borderline leprosy, and one tuberculoid leprosy. Clinically 5 patients had enanthem of the anterior pillars, 3 of the uvula and 3 of the palate. Two had palatal infiltration. Viable bacilli were found in two lepromatous patients. Biopsies of the buccal mucosa showed no change or a nonspecific inflammatory infiltrate. Oral clinical alterations were present in 69% of the patients; of these 50% showed histopathological features in an area without any lesion. DISCUSSION: Our clinical and histopathological findings corroborate earlier reports that there is a reduced incidence of oral changes, which is probably due to early treatment. The maintenance of oral infection in this area can also lead to and maintain lepra reactions, while they may also act as possible infection sources. Attention should be given to oral disease in leprosy because detection and treatment of oral lesions can prevent the spread of the disease.

Costa A; Nery J; Oliveira M; Cuzzi T; Silva M

2003-01-01

259

[Cartilaginous and bony anatomy of the human cotyloid cavity: preliminary study for the analysis of the specific dynamics of cotyloid cornua  

UK PubMed Central (United Kingdom)

Recent studies on acetabular and periacetabular deformations help to understand hip functioning. They encourage a new anatomic analysis of the bony and cartilagenous frameworth of the hip. The authors report as biomechanical preleminary, a radiological and anatomical study on the behavior of the periacetabular region. The results are compared to the anatomical litterature and conclusions are drawn.

Lazennec JY; Laudet CG; Roger B; Feron JM; Guerin-Surville H

1990-09-01

260

Skin lesions in histoplasmosis.  

Science.gov (United States)

Histoplasmosis is a granulomatous infection caused by Histoplasma capsulatum, a dimorphic fungus. It is distributed worldwide and prevalent in certain regions of North and Central America. Pulmonary involvement is the most common clinical presentation. Cutaneous manifestations are reported to occur in 10% to 25% of AIDS patients with disseminated histoplasmosis. The skin lesions are polymorphic papules, plaques with or without crusts, pustules, nodules, mucosal ulcers, erosions, punched out ulcers, lesions resembling molluscum contagiosum, acneiform eruptions, erythematosus papules and keratotic plaques, purpuric lesions, and localized and generalized vegetant forms of dermatitis, sometimes an eruption similar to rosacea, keratotic papules with transepidermal elimination, polymorphous erythema, erythroderma syndromes, pyoderma gangrenosum, panniculitis, diffuse hyperpigmentation, abscesses, and cellulitis. PMID:23068146

Chang, Patricia; Rodas, Cecilia

 
 
 
 
261

On-line image guidance for frameless stereotactic radiotherapy of lung malignancies by cone beam CT: Comparison between target localization and alignment on bony anatomy  

Energy Technology Data Exchange (ETDEWEB)

Introduction. Free-breathing stereotactic radiotherapy for lung malignancies requires reliable prediction of respiratory motion and accurate target localization. A protocol was adopted for reproducibility and reduction of respiratory motion and for target localization by CBCT image guidance. Tumor respiratory displacements and tumor positioning errors relative to bony anatomy alignment are analyzed. Materials and method. Image guided SRT was performed for 99 lung malignancies. Two groups of patients were considered: group A did not perform any breathing control; group B controlled visually their respiratory cycle and volumes on an Active Breathing Coordinator (ABC) monitor during the acquisition of simulation CT and CBCT, and treatment delivery. GTV on end inhale and exhale CT data sets were fused in an ITV and the extent of tumor motion evaluated between these 2 phases. A pre-treatment CBCT was acquired and aligned to the reference CT using bony anatomy; for tumor positioning the ITV contour on the reference CT was matched to the visible tumor on CBCT. Interobserver variability of tumor positioning was evaluated. ITV and CBCT tumor dimensions were compared. Results. 3D tumor breathing displacement (mean+-SD) was significantly higher for group A (14.7+-9.9 mm) than for group B (4.7+-3.1 mm). The detected differences between tumor and bony structure alignment below 3 mm were 68% for group B and 45% for group A, reaching statistical significance. Interobserver variability was 1.7+-1.1 mm (mean+-SD). Dimensions of tumor image on CBCT were consistent with ITV dimensions for group B (max difference 14%). Conclusions. The adopted protocol seems effective in reducing respiratory internal movements and margin. Tumor positioning errors relative to bony anatomy are also reduced. However bony anatomy as a surrogate of the target may still lead to some relevant positioning errors. Target visualization on CBCT is essential for an accurate localization in lung SRT

Masi, Laura; Casamassima, Franco; Menichelli, Claudia; Pasciuti, Katia; Doro, Raffaela; Polli, Caterina; D' imporzano, Elena; Bonucci, Ivano (Medical Physics Dept., Casa di Cura S. Chiara Firenze (Italy))

2008-08-15

262

Influence of buccal bony crest width on marginal dimensions of peri-implant hard and soft tissues after implant installation. An experimental study in dogs.  

UK PubMed Central (United Kingdom)

AIM: To evaluate the influence of the width of the buccal bony wall on hard and soft tissue dimensions following implant installation. MATERIAL AND METHODS: Mandibular premolars and first molars of six Labrador dogs were extracted bilaterally. After 3 months of healing, two recipient sites, one on each side of the mandible, were prepared in such a way as to obtain a buccal bony ridge width of about 2 mm in the right (control) and 1 mm in the left sides (test), respectively. Implants were installed with the coronal margin flush with the buccal alveolar bony crest. Abutments were placed and the flaps were sutured to allow a non-submerged healing. After 3 months, the animals were euthanized and ground sections obtained. RESULTS: All implants were completely osseointegrated. In respect to the coronal rough margin of the implant, the most coronal bone-to-implant contact was apically located 1.04 ± 0.91 and 0.94 ± 0.87 mm at the test and control sites, respectively, whereas the top of the bony crest was located 0.30 ± 0.40 mm at the test and 0.57 ± 0.49 mm at the control sites. No statistically significant differences were found. A larger horizontal bone resorption, however, evaluated 1 mm apically to the rough margin, was found at the control (1.1 ± 0.7 mm) compared to the test (0.3 ± 0.3 mm) sites, the difference being statistically significant. A thin peri-implant mucosa (2.4-2.6 mm) was found at implant installation while, after 3 months of healing, a biological width of 3.90-4.40 mm was observed with no statistically significant differences between control and test sites. CONCLUSIONS: A width of the buccal bony wall of 1or 2 mm at implant sites yielded similar results after 3 months of healing in relation of hard tissue and soft tissues dimensions after implant installation.

Baffone GM; Botticelli D; Pereira FP; Favero G; Schweikert M; Lang NP

2013-03-01

263

On-line image guidance for frameless stereotactic radiotherapy of lung malignancies by cone beam CT: Comparison between target localization and alignment on bony anatomy  

International Nuclear Information System (INIS)

Introduction. Free-breathing stereotactic radiotherapy for lung malignancies requires reliable prediction of respiratory motion and accurate target localization. A protocol was adopted for reproducibility and reduction of respiratory motion and for target localization by CBCT image guidance. Tumor respiratory displacements and tumor positioning errors relative to bony anatomy alignment are analyzed. Materials and method. Image guided SRT was performed for 99 lung malignancies. Two groups of patients were considered: group A did not perform any breathing control; group B controlled visually their respiratory cycle and volumes on an Active Breathing Coordinator (ABC) monitor during the acquisition of simulation CT and CBCT, and treatment delivery. GTV on end inhale and exhale CT data sets were fused in an ITV and the extent of tumor motion evaluated between these 2 phases. A pre-treatment CBCT was acquired and aligned to the reference CT using bony anatomy; for tumor positioning the ITV contour on the reference CT was matched to the visible tumor on CBCT. Interobserver variability of tumor positioning was evaluated. ITV and CBCT tumor dimensions were compared. Results. 3D tumor breathing displacement (mean±SD) was significantly higher for group A (14.7±9.9 mm) than for group B (4.7±3.1 mm). The detected differences between tumor and bony structure alignment below 3 mm were 68% for group B and 45% for group A, reaching statistical significance. Interobserver variability was 1.7±1.1 mm (mean±SD). Dimensions of tumor image on CBCT were consistent with ITV dimensions for group B (max difference 14%). Conclusions. The adopted protocol seems effective in reducing respiratory internal movements and margin. Tumor positioning errors relative to bony anatomy are also reduced. However bony anatomy as a surrogate of the target may still lead to some relevant positioning errors. Target visualization on CBCT is essential for an accurate localization in lung SRT

2008-01-01

264

Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions  

International Nuclear Information System (INIS)

[en] Aim: The aim of this study is to evaluate the value of the apparent diffusion coefficient (ADC) obtained in diffusion-weighted (DW) MR sequences for the differentiation between malignant and benign bone marrow lesions. Method: Forty-five patients with altered signal intensity vertebral bodies on conventional MR sequences were included. The cause of altered signal intensity was benign osteoporotic collapse in 16, acute neoplastic infiltration in 15, and infectious processes in 14; based on plain-film, CT, bone scintigraphy, conventional MR studies, biopsy or follow-up. All patients underwent isotropic DW MR images (multi-shot EPI, b values of 0 and 500 s/mm2). Signal intensity at DW MR images was evaluated and ADC values were calculated and compared between malignancy, benign edema and infectious spondylitis. Results: Acute malignant fractures were hyperintense compared to normal vertebral bodies on the diffusion-weighted sequence, except in one patient with sclerotic metastases. Mean ADC value from benign edema (1.9 ± 0.39 x 10-3 mm2/s) was significantly (p -3 mm2/s). Mean ADC value of infectious spondilytis (0.96 ± 0.49 x 10-3 mm2/s) was not statistically (p > 0.05) different from untreated metastasic lesions. ADC value was low (0.75 x 10-3 mm2/s) in one case of subacute benign fracture. Conclusions: ADC values are a useful complementary tool to characterize bone marrow lesions, in order to distinguish acute benign fractures from malignant or infectious bone lesions. However, ADC values are not valuable in order to differentiate malignancy from infection.

2009-01-01

265

The posterior cruciate ligament: a study on its bony and soft tissue anatomy using novel 3D CT technology.  

UK PubMed Central (United Kingdom)

PURPOSE: The bony insertion sites of the PCL have been studied and described extensively using 2D technology such as macroscopic images, plain radiograph, computerized tomography (CT) and MRI. The purpose of this study is to visualize both the tibial and the femoral bony insertion sites but also the soft tissue anatomy of the native PCL using novel 3D CT imaging. In addition, new concepts of best-fit cylinder and central axis are introduced and evaluated. METHODS: Nine unpaired knees of embalmed cadavers were used in this study. Following the dissection process, the PCL was injected with a contrast medium for computed tomography (CT) imaging. The obtained CT images were segmented and rendered in 3D allowing morphological and morphometric analysis of PCL. Femoral and tibial footprint surface area, best-fit PCL-cylinder intersection area, best-fit PCL-cylinder/footprint coverage ratio, best-fit PCL-cylinder central axis projections at the tibial and femoral footprint were used to describe the anatomy of the PCL. RESULTS: Mean footprint surface area of the tibial and femoral footprint were 189.1 and 293.3 mm², respectively. The mean diameter of the best-fit cylinder was 10.5 mm. The mean coverage of the best-fit cylinder on the tibial and femoral footprint was 76.5 and 46.5, respectively. The best-fit cylinder central axis was located in the anterolateral AL bundle footprint on the femur and more centrally in the PCL footprint on the tibia. CONCLUSION: This study is the first to describe the detailed anatomy of the human PCL with respect to its course and footprints using a 3D approach. It confirms the large difference between the tibial and the femoral footprint area with the former being significantly smaller. In addition, a large inter-patient variability is observed. The best-fit cylinder and central axis concept offer additional insights into the optimal tunnel placement at the tibia and femoral footprint in order to cover the largest portion of the native PCL soft tissue.

Van Hoof T; Cromheecke M; Tampere T; D'herde K; Victor J; Verdonk PC

2013-05-01

266

Reappearing CT lesions : 4 cases.  

Directory of Open Access Journals (Sweden)

Full Text Available An overwhelming majority of disappearing CT lesions in India have been aetiologically linked to cysticercosis. We report 4 patients with disappearing CT lesions in whom the lesion later reappeared at the same (3 patients) or different site (1 patient). One patient was a Taenia carrier. Serial MRI evaluation in one patient revealed a persisting lesion in the interval period. The contribution of these observations towards the understanding of the aetiology of disappearing CT lesions is discussed.

Singh G; Bhatia R; Khurana D; Khurana S

1999-01-01

267

Pigmented lesions of the vulva.  

Science.gov (United States)

Approximately one of every 10 women has a pigmented vulvar lesion. Given the risk of melanomas and pigmented vulvar intraepithelial neoplasia (squamous cell carcinoma in situ), proper evaluation of vulvar pigmented lesions is critical. Most vulvar lesions are benign; however, vulvar lesions grossly, dermoscopically, and histologically can appear atypical compared with pigmented lesions on the rest of the body. Thus, it is imperative to use not only a keen eye but also a low threshold for biopsy. PMID:20883921

Venkatesan, Aruna

2010-10-01

268

Pigmented lesions of the vulva.  

UK PubMed Central (United Kingdom)

Approximately one of every 10 women has a pigmented vulvar lesion. Given the risk of melanomas and pigmented vulvar intraepithelial neoplasia (squamous cell carcinoma in situ), proper evaluation of vulvar pigmented lesions is critical. Most vulvar lesions are benign; however, vulvar lesions grossly, dermoscopically, and histologically can appear atypical compared with pigmented lesions on the rest of the body. Thus, it is imperative to use not only a keen eye but also a low threshold for biopsy.

Venkatesan A

2010-10-01

269

Radiologic diagnosis of the shoulder dislocation and its associated osseous lesions  

International Nuclear Information System (INIS)

Among the dislocations of the larger joints of the human body, those of the shoulder are the most frequent ones. They are often associated with osseous lesions, which are of importance in treatment and prognosis. Radiologic diagnostic procedures must take this into consideration in view of the causal mechanisms of trauma. In search for the bony lesions, routine techniques of projection exist which are evidently not always used as often as would be desirable. These projections also help to detect and to accurately locate the dislocation, which may sometimes be difficult to diagnose. Posterior dislocations, for example, are misdiagnosed or overlooked radiologically (and clinically) in about 50% of the cases. This could partly be avoided by the consequent use of a few, but essential projection procedures. (orig.)

1983-01-01

270

[Corneal lesions in ichthyosis  

UK PubMed Central (United Kingdom)

Corneal lesions in ichthyosis, here combined with alopecia, are rarely described in the literature. The present observation relates to two sisters, whose grandparents were siblings. The mode of inheritance is autosomal recessive, as is usual in ichthyosis congenita but is also observed in ichthyosis vulgaris. The clinical picture and the histological findings correspond to ichthyosis vulgaris.

Hammerstein W; Meiers HG; Haensch R

1976-01-01

271

Immunopathology of skin lesions  

Directory of Open Access Journals (Sweden)

Full Text Available A study was conducted on 130 patients suffering from skin lesions which included psoriasis, lichen planus, DLE, pemphigus, vitiligo and alopecia areata. Forty age-and-sex-matched healthy individuals served as control. Serum IgG, IgM, and circulating immune complexes (CIC) were estimated. Significant increase in serum IgG (1937.2 ± 1030.43 mg%) and IgM (232.12 ± 136.98 mg%) was observed in all the skin lesions when compared with controls except in lichen planus where they were significantly lowered, values being 580.61± 77.35 mg% and 66.88 ± 6.59mg% respectively. CIC levels were significantly raised (P<0.00 1) in various skin lesions (40.49±23.29) when compared with controls (17.68± 3.21), but no significance was observed in lichen planus( 17.72 ± 4.28). Serum IgG, IgM and CIC were statistically significantly altered depending on the extent of the lesion and lowered significantly to almost normal values following treatment, thereby confirming the role of immunity in the pathogenesis of these skin disorders.

Khan Nazoora; Maheshwari Veena; Trivedi Indu; Kalam Abul

2001-01-01

272

Radiological diagnosis of chronic spinal cord compressive lesion at thoraco-lumbar junction  

Energy Technology Data Exchange (ETDEWEB)

Radiological findings in five cases with chronic spinal cord compressive lesion at thoraco-lumbar junction were reported. Three cases had spondylosis and two cases had ossification of yellow ligament (OYL). The levels of the lesions were T12/L1 in three cases and T11/12 in two cases. Two out of three spondylotic patients had also OYL at the same level. The five cases consisted of three men and two women. The ages ranged from 42 to 60 years old with a mean age of 53 years old. Neurologically, every patient showed flaccid paresis and sensory disturbance of the legs. Two cases had sensory disturbance of stocking type. The intervals from the onset of the symptoms to the final diagnosis were 6 months, 7 years, 8 years, 11 years and 12 years. Myelography showed anterior spinal cord compression by bony spur in spondylotic patients, and posterior compression by OYL in other cases. Myelography in flexion posture disclosed the cord compression by bony spur more clearly in two out of three spondylotic patients. Delayed CT-myelography showed intramedullary filling of contrast material in two cases, which indicated degenerative change or microcavitation due to long term compression of the spinal cord. MRI was taken in three spondylotic patients and could directly show compression of the spinal cord. Difficulty in detecting abnormality at thoraco-lumbar junction on plain roentgenogram, and similarity of the symptoms to peripheral nerve disease often lead to a delay in diagnosis. The significance of dynamic myelography and delayed CT-myelography when dealing with such a lesion was discussed here. MRI is also a useful method for diagnosing a compressive lesion at the thoraco-lumbar junction.

Koyanagi, Izumi; Isu, Toyohiko; Iwasaki, Yoshinobu; Akino, Minoru; Abe, Hiroshi; Tashiro, Kunio; Miyasaka, Kazuo; Abe, Satoru; Kaneda, Kiyoshi

1988-10-01

273

Radiological diagnosis of chronic spinal cord compressive lesion at thoraco-lumbar junction  

International Nuclear Information System (INIS)

Radiological findings in five cases with chronic spinal cord compressive lesion at thoraco-lumbar junction were reported. Three cases had spondylosis and two cases had ossification of yellow ligament (OYL). The levels of the lesions were T12/L1 in three cases and T11/12 in two cases. Two out of three spondylotic patients had also OYL at the same level. The five cases consisted of three men and two women. The ages ranged from 42 to 60 years old with a mean age of 53 years old. Neurologically, every patient showed flaccid paresis and sensory disturbance of the legs. Two cases had sensory disturbance of stocking type. The intervals from the onset of the symptoms to the final diagnosis were 6 months, 7 years, 8 years, 11 years and 12 years. Myelography showed anterior spinal cord compression by bony spur in spondylotic patients, and posterior compression by OYL in other cases. Myelography in flexion posture disclosed the cord compression by bony spur more clearly in two out of three spondylotic patients. Delayed CT-myelography showed intramedullary filling of contrast material in two cases, which indicated degenerative change or microcavitation due to long term compression of the spinal cord. MRI was taken in three spondylotic patients and could directly show compression of the spinal cord. Difficulty in detecting abnormality at thoraco-lumbar junction on plain roentgenogram, and similarity of the symptoms to peripheral nerve disease often lead to a delay in diagnosis. The significance of dynamic myelography and delayed CT-myelography when dealing with such a lesion was discussed here. MRI is also a useful method for diagnosing a compressive lesion at the thoraco-lumbar junction. (author).

1988-01-01

274

A new species of Hyphessobrycon (Teleostei: Characidae) from the upper rio Tocantins drainage, with bony hooks on fins  

Directory of Open Access Journals (Sweden)

Full Text Available A new species of characid, Hyphessobrycon hamatus, is described from the upper rio Tocantins, Goiás, Brazil. The new species is distinguished from all other Hyphessobrycon species by the presence of bony hooks on dorsal, anal, pelvic, and pectoral fins of males, the two black humeral spots, the 4 or 5 teeth in the inner series of the premaxilla, a maxilla with 2-3 teeth, the iii-v, 16-18 anal-fin rays, and a lateral line with 10-32 perforated scales and 33-35 scales in a longitudinal series.Uma nova espécie de caracídeo, Hyphessobrycon hamatus é descrita para os tributários do alto rio Tocantins, Goiás, Brasil. A nova espécie distingue-se das demais espécies de Hyphessobrycon pela presença de ganchos nos raios das nadadeiras dorsal, anal, pélvica e peitoral dos machos, duas manchas umerais pretas verticalmente alongadas, 4-5 dentes na série interna do pré-maxilar, 2-3 dentes no maxilar, 16-18 raios ramificados na nadadeira anal, 10-32 escamas perfuradas na linha lateral, e 33-35 escamas em uma série longitudinal.

Vinicius A. Bertaco; Luiz R. Malabarba

2005-01-01

275

New bioresorbable pin for the reduction of small bony fragments: design, mechanical properties and in vitro degradation.  

UK PubMed Central (United Kingdom)

The design, material properties, and in vivo degradation characteristics of a new resorbable pin for the reductions of small bony fragments are described. The Polypin, made of 70:30 poly (L, DL-lactide), had an initial bending strength of 155-163 MPa, as measured by a three-point bending test. Ethylene oxide (EO)- and gamma-sterilization did not substantially affect its initial mechanical properties. The initial molecular weight (Mw) of 523,000 to 600,000, however, decreased 60-75% after gamma-sterilization. Incubation of the EO-sterilized pins in 37 degrees C saline solution produced a complete loss of bending strength at 18 months. An accelerated test at 70 degrees C led to a complete loss of strength after only 96 h. Degradation of the gamma-sterilized pin at 70 degrees C was about 30% faster than that of the EO-sterilized pin. Bending strength and molecular weight were unaffected by storage at room temperature for 46 months. The relatively slow strength loss rate of the Polypin potentially extends the application of resorbable devices to slow-healing fractures. The new pin design allows application of light interfragmentary compression, thus reducing the risk of pin loosening, and an X-ray marker is provided.

Claes LE; Ignatius AA; Rehm KE; Scholz C

1996-08-01

276

Systemic and local reactions of a water-soluble copolymer bone on a bony defect of rabbit model.  

UK PubMed Central (United Kingdom)

BACKGROUND: Ostene, a synthetic water-soluble bone hemostatic agent, is commercially available. In the current study, we evaluated the systemic and local effects of this copolymer in a rabbit model. METHODS: Eighteen rabbits underwent creation of a bony defect at right iliac crest. These rabbits were then evenly divided into 3 groups. In group 1, the defect surfaces were treated with bone wax; in group 2, the defect surfaces were treated with Ostene; in group 3, the defect surfaces were not treated with anything. Then, the animals underwent blood examinations, including WBC count, CRP, and ESR at 0, 1, 3, and 6 weeks, and were killed at 6 weeks for histologic examination. Another 6 rabbits (group 4) underwent the same surgical treatment of group 2 animals but had blood examinations of BUN and creatinine. RESULTS: The blood examinations showed that the WBC count, CRP, and ESR of all the animals in the first 3 groups were within normal limits in the postoperative periods. Microscopic examinations demonstrated residual bone wax and fibrotic tissue at the defect surfaces in group 1 animals. However, there was no Ostene at the defect surfaces in group 2 animals. The groups 2 and 3 animals showed no fibrotic tissue at the defect surfaces. The group 4 animals showed normal serum levels of BUN and creatinine in the postoperative periods. CONCLUSION: Ostene is absorbable and induces no systemic inflammation (including acute renal damage) and local inflammation in animal bodies.

Lee TC; Chang NK; Su FW; Yang YL; Su TM; Lin YJ; Lin WC; Huang HY

2009-12-01

277

Comparative clinicoanatomical study of ilium and fibula as two commonly used bony donor sites for maxillofacial reconstruction.  

UK PubMed Central (United Kingdom)

We assessed the morphological characteristics and dimensions of the ilium and fibula to evaluate the suitability of particular areas of bone for use as donor sites for dental reconstructions that carry implants. We measured the dimensions of 130 bilaterally harvested ilium and fibula bones from 65 adult cadavers using osteometric methods, and analysed the effects of age, sex, and side. Dimensions at measuring points, overall suitability for implantation, and relations among age, sex, and side, were evaluated statistically. We report observations of bone morphology involving cross-sections, and clinical relevance. Although the mean dimensions of the fibula and iliac crest were adequate, some segments would not support an implant 10mm long and 3.5mm wide. The overall suitability of parts of the iliac block fell to 30%. Fibular morphology is characterised by constant height and width, and relation of cortical and cancellous bone. Bony dimensions on the iliac fossa and fibula were significantly greater in men than in women. Age had a negative impact in one area of the iliac fossa, but nowhere on the iliac crest. Side was not significant. We found differences in dimensions and morphology between measuring points on the same bone. Precise knowledge about which areas of the donor sites can reliably provide sufficient bone to carry implants after reconstructions will allow greater flexibility and safety when reconstructions are designed.

Sönmez TT; Prescher A; Salama A; Kanatas A; Zor F; Mitchell D; Zaker Shahrak A; Karaaltin MV; Knobe M; Külahci Y; Altuntas SH; Ghassemi A; Hölzle F

2013-08-01

278

Przemiany reaktywnych form tlenu w do?wiadczalnym, stresowym modelu uszkodze? b?ony ?luzowej ?o??dka  

Directory of Open Access Journals (Sweden)

Full Text Available Reaktywne formy tlenu maj? wysok? chemiczn? reaktywno?? spowodowan? obecno?ci? niesparowanego elektronu w ich cz?steczkach. Dlatego te? powoduj? powstawanie uszkodze? tkankowych, które s? w szczególno?ci efektem utlenienia lipidów. Nadtlenki lipidów s? metabolizowane do malonylodialdehydu (MDA) i 4-hydroksynonenalu (4-HNE). Wzrost st??enia MDA i 4-HNE wskazuje na uszkodzenie tkanek zale?ne od reaktywnych form tlenu. Dysmutaza ponadtlenkowa (SOD) jest g?ównym enzymem, który neutralizuje reaktywne formy tlenu do mniej szkodliwego nadtlenku wodoru. Spadek aktywno?ci SOD zwi?zany jest z niewydolno?ci? mechanizmów obronnych i prowadzi do powstawania uszkodze? tkankowych. Nadtlenek wodoru jest dalej metabolizowany do wody, w obecno?ci zredukowanego glutationu (GSH). Spadek poziomu GSH ma niekorzystne konsekwencje dla zdolno?ci komórek do obrony antyoksydacyjnej. B?ona ?luzowa ?o??dka, w warunkach stresowych, wykazuje zwi?kszenie nat??enia procesu utleniania lipidów (wzrost MDA i 4-HNE), jak równie? spadek aktywno?ci SOD i st??enia GSH. Te wska?niki wydaj? si? by? u?yteczne w zrozumieniu patomechanizmów powstawania uszkodze? b?ony ?luzowej ?o??dka w warunkach stresowych.

S?awomir Kwiecie?; Micha? W. Pawlik; Tomasz Brzozowski; Wies?aw W. Pawlik; Stanis?aw J. Konturek

2010-01-01

279

Lesiones deportivas/ Sports injuries  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish El estrés generado por la práctica deportiva ha originado una mayor probabilidad de que los atletas presenten lesiones agudas y crónicas. En el ámbito mundial existen diferentes investigaciones acerca de la incidencia de lesiones deportivas. La comparación de sus resultados es difícil por las diferencias en las características de la población y en la forma de reportar los datos, que varía ampliamente entre los estudios (proporciones o tasas de incidencia o tasas (more) por cada 100 ó 1.000 participantes o tasas por horas de juego o por número de partidos jugados). Las tasas varían entre 1,7 y 53 lesiones por 1.000 horas de práctica deportiva, entre 0,8 y 90,9 por 1.000 horas de entrenamiento, entre 3,1 y 54,8 por 1.000 horas de competición y de 6,1 a 10,9 por 100 juegos. La gran variación entre las tasas de incidencia se explica por las diferencias existentes entre los deportes, los países, el nivel competitivo, las edades y la metodología empleada en los estudios. Se ha definido la lesión deportiva como la que ocurre cuando los atletas están expuestos a la práctica del deporte y se produce alteración o daño de un tejido, afectando el funcionamiento de la estructura. Los deportes de contacto generan mayor riesgo de presentar lesiones; se destacan al respecto los siguientes: fútbol, rugby, baloncesto, balonmano, artes marciales y jockey. Las lesiones ocurren con mayor probabilidad en las competencias que en el entrenamiento. Abstract in english Stress generated by sports practice has increased the probability that athletes suffer from acute and chronic injuries. Worldwide, there have been many different investigations concerning the incidence of sport injuries. The different ways in which results have been presented makes it difficult to compare among them. Rates of sports injuries vary between 1.7 and 53 per 1.000 hours of sports practice; 0.8 and 90.9 per 1.000 hours of training; 3.1 and 54.8 per 1.000 hours o (more) f competition, and 6.1 and 10.9 per 100 games. The great variability among the incidence rates may be explained by differences among sports, countries, competitive levels, ages and methodology used in the studies. Sports injuries have been defined as those occurring when athletes are practicing sports and that result in tissue alterations or damages, affecting the operation of the corresponding structures. Contact sports such as soccer, rugby, martial arts, basketball, handball and hockey generate greater risk of injuries. The probability of lesions is higher during competition than in training.

OSORIO CIRO, JORGE ALBERTO; CLAVIJO RODRÍGUEZ, MÓNICA PAOLA; ARANGO V, ELKIN; PATIÑO GIRALDO, SANTIAGO; GALLEGO CHING, ISABEL CRISTINA

2007-06-01

280

Lesiones deportivas Sports injuries  

Directory of Open Access Journals (Sweden)

Full Text Available El estrés generado por la práctica deportiva ha originado una mayor probabilidad de que los atletas presenten lesiones agudas y crónicas. En el ámbito mundial existen diferentes investigaciones acerca de la incidencia de lesiones deportivas. La comparación de sus resultados es difícil por las diferencias en las características de la población y en la forma de reportar los datos, que varía ampliamente entre los estudios (proporciones o tasas de incidencia o tasas por cada 100 ó 1.000 participantes o tasas por horas de juego o por número de partidos jugados). Las tasas varían entre 1,7 y 53 lesiones por 1.000 horas de práctica deportiva, entre 0,8 y 90,9 por 1.000 horas de entrenamiento, entre 3,1 y 54,8 por 1.000 horas de competición y de 6,1 a 10,9 por 100 juegos. La gran variación entre las tasas de incidencia se explica por las diferencias existentes entre los deportes, los países, el nivel competitivo, las edades y la metodología empleada en los estudios. Se ha definido la lesión deportiva como la que ocurre cuando los atletas están expuestos a la práctica del deporte y se produce alteración o daño de un tejido, afectando el funcionamiento de la estructura. Los deportes de contacto generan mayor riesgo de presentar lesiones; se destacan al respecto los siguientes: fútbol, rugby, baloncesto, balonmano, artes marciales y jockey. Las lesiones ocurren con mayor probabilidad en las competencias que en el entrenamiento. Stress generated by sports practice has increased the probability that athletes suffer from acute and chronic injuries. Worldwide, there have been many different investigations concerning the incidence of sport injuries. The different ways in which results have been presented makes it difficult to compare among them. Rates of sports injuries vary between 1.7 and 53 per 1.000 hours of sports practice; 0.8 and 90.9 per 1.000 hours of training; 3.1 and 54.8 per 1.000 hours of competition, and 6.1 and 10.9 per 100 games. The great variability among the incidence rates may be explained by differences among sports, countries, competitive levels, ages and methodology used in the studies. Sports injuries have been defined as those occurring when athletes are practicing sports and that result in tissue alterations or damages, affecting the operation of the corresponding structures. Contact sports such as soccer, rugby, martial arts, basketball, handball and hockey generate greater risk of injuries. The probability of lesions is higher during competition than in training.

Jorge Alberto Osorio Ciro; Mónica Paola Clavijo Rodríguez; Elkín Arango V.; Santiago Patiño Giraldo; Isabel Cristina Gallego Ching

2007-01-01

 
 
 
 
281

Sports injuries Lesiones deportivas  

Directory of Open Access Journals (Sweden)

Full Text Available Stress generated by sports practice has increased the probability that athletes suffer from acute and chronic injuries. Worldwide, there have been many different investigations concerning the incidence of sport injuries. The different ways in which results have been presented makes it difficult to compare among them. Rates of sports injuries vary between 1.7 and 53 per 1.000 hours of sports practice; 0.8 and 90.9 per 1.000 hours of training; 3.1 and 54.8 per 1.000 hours of competition, and 6.1 and 10.9 per 100 games. The great variability among the incidence rates may be explained by differences among sports, countries, competitive levels, ages and methodology used in the studies. Sports injuries have been defined as those occurring when athletes are practicing sports and that result in tissue alterations or damages, affecting the operation of the corresponding structures. Contact sports such as soccer, rugby, martial arts, basketball, handball and hockey generate greater risk of injuries. The probability of lesions is higher during competition than in training. El estrés generado por la práctica deportiva ha originado una mayor probabilidad de que los atletas presenten lesiones agudas y crónicas. En el ámbito mundial existen diferentes investigaciones acerca de la incidencia de lesiones deportivas. La comparación de sus resultados es difícil por las diferencias en las características de la población y en la forma de reportar los datos, que varía ampliamente entre los estudios (proporciones o tasas de incidencia o tasas por cada 100 ó 1.000 participantes o tasas por horas de juego o por número de partidos jugados). Las tasas varían entre 1,7 y 53 lesiones por 1.000 horas de práctica deportiva, entre 0,8 y 90,9 por 1.000 horas de entrenamiento, entre 3,1 y 54,8 por 1.000 horas de competición y de 6,1 a 10,9 por 100 juegos. La gran variación entre las tasas de incidencia se explica por las diferencias existentes entre los deportes, los países, el nivel competitivo, las edades y la metodología empleada en los estudios. Se ha definido la lesión deportiva como la que ocurre cuando los atletas están expuestos a la práctica del deporte y se produce alteración o daño de un tejido, afectando el funcionamiento de la estructura. Los deportes de contacto generan mayor riesgo de presentar lesiones; se destacan al respecto los siguientes: fútbol, rugby, baloncesto, balonmano, artes marciales y jockey. Las lesiones ocurren con mayor probabilidad en las competencias que en el entrenamiento.

Jorge Alberto Osorio Ciro; Mónica Paola Clavijo Rodríguez; Elkín Arango V.; Santiago Patiño Giraldo; Isabel Cristina Gallego Ching

2007-01-01

282

Influence of presence or absence of keratinized mucosa on the alveolar bony crest level as it relates to different buccal marginal bone thicknesses. An experimental study in dogs.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To investigate the influence of the presence or absence of keratinized mucosa on the alveolar bony crest level as it relates to different buccal marginal bone thicknesses. MATERIAL AND METHODS: In six beagle dogs, the mandibular premolars and first molars were extracted bilaterally. In the right side of the mandible (test), flaps were elevated, and the buccal as well as part of the lingual masticatory mucosa was removed. The flap was released coronally to allow a primary wound closure. In the left side, the wounds were left unsutured with the keratinized mucosa remaining (control). After 3 months of healing, a complete absence of keratinized mucosa was found at the test sites. Two recipient sites were prepared at each side of the mandible, one in the premolar and one in the molar region. A buccal bony ridge width of approximately 1 and 2 mm was obtained at the premolar and molar region, respectively. Implants were installed with the shoulder flush with the buccal alveolar bony crest, and abutments were connected to allow a nonsubmerged healing. At least 2 mm of keratinized mucosa was surrounding the control sites, while at the test sites, the implants were bordered by alveolar mucosa. After 3 months, the animals were euthanized and ground sections obtained. RESULTS: A higher vertical bony crest resorption was observed at the test compared with the control sites both at the premolar and molar regions, the differences being statistically significant. The top of the peri-implant mucosa was located more coronally at the control compared with the test sites. The horizontal resorption measured 1 mm below the implant shoulder was similar at the test and control sites. Only limited differences were found between premolar and molar sites, with the exclusion of the horizontal resorption that was higher at the test compared with the control sites. CONCLUSIONS: A higher alveolar buccal bony crest resorption and a more apical soft tissue marginal position should be expected, when implants are surrounded with thin alveolar mucosa at the time of installation, independently of the thickness of the buccal bony crest.

Bengazi F; Botticelli D; Favero V; Perini A; Urbizo Velez J; Lang NP

2013-07-01

283

[Enlarging pigmented facial lesion].  

UK PubMed Central (United Kingdom)

A 75-year-old man presented after recurrence of a pigmented macule on his left cheek. Approximately 8 month before a seborrheic keratosis had been diagnosed clinically and treated with cryosurgery and curettage. Dermatoscopy of the recurrent lesion revealed a number of criteria associated with lentigo maligna including asymmetric pigmented follicular openings, streaks, rhomboidal structures, and homogeneous slate-gray areas. Histopathology confirmed a lentigo maligna melanoma with a Breslow tumor thickness of 0.3 mm.

Haenssle HA

2012-02-01

284

Asymptomatic ischemic cerebral lesions  

International Nuclear Information System (INIS)

For the purpose of studying the incidence, pathomorphology and etiology of asymptomatic ischemic cerebral lesions, we carried out a brain MRI study on 65 patients with diabetes mellitus accompanied with hypertension who are thought to belong to a high risk group of ischemic cerebrovascular diseases. Excluding the abnormality of tendon reflex due to diabetic neuropathy, sixty percent of the total patients had some mild neurological signs and symptoms, most of them was discrepancy in tendon reflex. The percentage of the patients in whom MRI disclosed some abnormalities was as high as 70%, they were lacunar stroke, multiple lacunar state, cortical infarct, and patchy high signal lesions visible only in the T2 weighted image. Lacunes or these patchy high signal lesions (considered to be the dilatation of the perivascular space or true lacunes) tended to be found along the border zone or the terminal zone. These results indicate that asymptomatic patients in whom MRI discloses the abnormalities should be considered as candidates for the future onset of multi-infarct. (author).

1988-01-01

285

Management of ampullary lesions.  

UK PubMed Central (United Kingdom)

Adenomatous lesions of the ampulla of Vater are relatively rare neoplasms that raise many questions regarding standard management. Adenocarcinoma often will be found in ampullary lesions and should be treated by pancreaticoduodenectomy (PD). Benign-appearing adenomas may be treated by PD, transduodenal ampullectomy (AMP), or endoscopic ampullectomy (EA). AMP and EA have decreased morbidity and mortality compared with PD but are limited by concerns for appropriate resection margins, high recurrence rates, and the need for surveillance endoscopy or additional procedures. Preoperative endoscopic biopsies should be obtained to identify carcinoma, but they have high false-negative rates and cannot be relied upon to rule out malignancy. Intraoperative frozen section evaluation should be requested routinely during AMP, with conversion to PD if carcinoma is demonstrated. The gold standard management of benign adenomas has not been clarified, but the goal for all treatment modalities is complete resection. Patients with familial adenomatous polyposis may be exceptions to this, and routine surveillance endoscopy and biopsy with selective resection have been advocated by some as an alternative to complete resection. Adjuvant chemoradiation has a very limited role in the treatment of ampullary carcinoma and ideally should be offered in the setting of a clinical trial. Metastatic and locally advanced, unresectable lesions may be palliated by surgical or endoscopic bypass, as well as by celiac plexus blockade.

Dittrick GW; Mallat DB; Lamont JP

2006-09-01

286

Management of ampullary lesions.  

Science.gov (United States)

Adenomatous lesions of the ampulla of Vater are relatively rare neoplasms that raise many questions regarding standard management. Adenocarcinoma often will be found in ampullary lesions and should be treated by pancreaticoduodenectomy (PD). Benign-appearing adenomas may be treated by PD, transduodenal ampullectomy (AMP), or endoscopic ampullectomy (EA). AMP and EA have decreased morbidity and mortality compared with PD but are limited by concerns for appropriate resection margins, high recurrence rates, and the need for surveillance endoscopy or additional procedures. Preoperative endoscopic biopsies should be obtained to identify carcinoma, but they have high false-negative rates and cannot be relied upon to rule out malignancy. Intraoperative frozen section evaluation should be requested routinely during AMP, with conversion to PD if carcinoma is demonstrated. The gold standard management of benign adenomas has not been clarified, but the goal for all treatment modalities is complete resection. Patients with familial adenomatous polyposis may be exceptions to this, and routine surveillance endoscopy and biopsy with selective resection have been advocated by some as an alternative to complete resection. Adjuvant chemoradiation has a very limited role in the treatment of ampullary carcinoma and ideally should be offered in the setting of a clinical trial. Metastatic and locally advanced, unresectable lesions may be palliated by surgical or endoscopic bypass, as well as by celiac plexus blockade. PMID:16942661

Dittrick, George W; Mallat, Damien B; Lamont, Jeffrey P

2006-09-01

287

Implante de biomateriais e a consolidação óssea em cadelas submetidas à ovariossalpingo-histerectomia/ Influence of biomaterials on the bony consolidation in spayed female dogs  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Avaliou-se a hidroxiapatita com alandronato e hidroxiapatita com colágeno na aceleração da consolidação óssea do rádio de cadelas adultas submetidas à ovariossalpingo-histerectomia (OSH). Utilizaram-se 14 cadelas adultas, distribuídas aleatoriamente em dois grupos: grupo-controle e grupo OSH (submetidas à OSH). Quatro meses após a OSH, as cadelas dos dois grupos foram submetidas à cirurgia para produção de uma falha óssea de 4mm de diâmetro nos terços dis (more) tal e proximal do rádio. No terço distal do membro direito, foi utilizada a hidroxiapatita com alandronato e, no membro esquerdo, a hidroxiapatita com colágeno; no terço proximal, não se utilizou nenhum biomaterial. Houve retardo na consolidação das falhas ósseas nas cadelas submetidas à OSH comparadas com as não submetidas. A hidroxiapatita com alandronato acelerou o processo de reparação e, em todos os animais dos dois grupos, a densidade óssea foi significativamente maior no terço distal onde foi implantada. Os dois biomateriais apresentaram biocompatibilidade, constatada pela ausência de reação inflamatória ou outra reação indesejável. Abstract in english The hydroxyapatite with alendronate and hydroxyapatite with collagen were evaluated in the acceleration of the bony consolidation of adult spayed bitch radius. For that, 14 adult bitches were distributed in two groups (control and spayed). Four months after ovariohysterectomy, the groups were submitted to the surgery for production of a 4mm diameter bony flaw in the distal and proximal third regions of the radius. In the distal region of the right thoracic limb, hydroxyap (more) atite with alendronate was used. In the distal region of the left thoracic limb, hydroxyapatite with collagen was used. Any biomaterial was used in proximal part of the limb. There was a retard in bony flaws consolidation in the spayed bitches. Hydroxyapatite with alendronate showed better result, since the place it was implanted considerably increased the bony formation. Both biomaterials presented biocompatibility, verified by the absence of inflammatory reaction or other undesirable reaction.

Roque-Rodriguez, A.I.; Baraldi-Artoni, S.M.; Oliveira, D.

2009-10-01

288

The significance of a hypoplastic bony canal for the cochlear nerve in patients with sensorineural hearing loss: CT and MRI findings  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study is to evaluate the significance of the hypoplastic canal for the cochlear nerve in patients with sensorineural hearing loss (SNHL) and the relationship between the hypoplastic bony canal and aplasia or hypoplasia of the cochlear nerve. A retrospective review of high resolution temporal CT(HRCT) and MRI findings was conducted. The narrow bony canal of the cochlear nerve and the relative size of the internal auditory canal were correlated with the cochlear nerve deficiency on MRI. The comparative size of the component nerves (facial, cochlear, superior vestibular, inferior vestibular nerve), and the relative size of the internal auditory canal and the bony canal of the cochlear nerve were measured. The clinical history and the results of the clinical examination were reviewed for each patient. High resolution MRI showed aplasia of the common vestibulocochlear nerve in one patient and a deficiency of the cochlear nerve in 9 patients. These abnormalities occurred in association with a prominent narrowing of the canal for the cochlear nerve and a stenosis of the internal auditory canal, which was observed on temporal bone CT in 9 patients with congenital SNHL. Three patients had normal IAC, despite the presence of a hypoplastic cochlear nerve on the side on which they had SNHL. In one patient, the narrowing of the canal for the cochlear nerve and internal auditory canal were not found to be associated with acquired SNHL. The hypoplastic bony canal for the cochlear nerve might be more highly indicative of congenital cochlear nerve deficiency than that of the narrow internal auditory canal, and the position of the crista falciformis should also be carefully.

Choi, Yoon Jung; Park, Sang Yoo; Kim, Myung Soon; Sung, Ki Jun [College of Medicine, Yonsei Univ., Wonju (Korea, Republic of)

2004-04-01

289

The significance of a hypoplastic bony canal for the cochlear nerve in patients with sensorineural hearing loss: CT and MRI findings  

International Nuclear Information System (INIS)

The purpose of this study is to evaluate the significance of the hypoplastic canal for the cochlear nerve in patients with sensorineural hearing loss (SNHL) and the relationship between the hypoplastic bony canal and aplasia or hypoplasia of the cochlear nerve. A retrospective review of high resolution temporal CT(HRCT) and MRI findings was conducted. The narrow bony canal of the cochlear nerve and the relative size of the internal auditory canal were correlated with the cochlear nerve deficiency on MRI. The comparative size of the component nerves (facial, cochlear, superior vestibular, inferior vestibular nerve), and the relative size of the internal auditory canal and the bony canal of the cochlear nerve were measured. The clinical history and the results of the clinical examination were reviewed for each patient. High resolution MRI showed aplasia of the common vestibulocochlear nerve in one patient and a deficiency of the cochlear nerve in 9 patients. These abnormalities occurred in association with a prominent narrowing of the canal for the cochlear nerve and a stenosis of the internal auditory canal, which was observed on temporal bone CT in 9 patients with congenital SNHL. Three patients had normal IAC, despite the presence of a hypoplastic cochlear nerve on the side on which they had SNHL. In one patient, the narrowing of the canal for the cochlear nerve and internal auditory canal were not found to be associated with acquired SNHL. The hypoplastic bony canal for the cochlear nerve might be more highly indicative of congenital cochlear nerve deficiency than that of the narrow internal auditory canal, and the position of the crista falciformis should also be carefully.

2004-01-01

290

Emerging ideas: Novel 3-D quantification and classification of cam lesions in patients with femoroacetabular impingement.  

UK PubMed Central (United Kingdom)

BACKGROUND: Femoroacetabular impingement (FAI) can lead to labral injury, osseous changes, and even osteoarthritis. The literature contains inconsistent definitions of the alpha angle and other nonthree-dimensional (3-D) radiographic measures. We present a novel approach to quantifying cam lesions in 3-D terms. Our method also can be used to develop a classification system that describes the exact location and size of cam lesions. QUESTIONS/HYPOTHESES: We asked whether automated quantification of CAM lesions based on CT data is a reasonable way to detect CAM lesions and whether they may be classified based on location. METHOD OF STUDY: We developed a method to quantify femoral head cam lesions using 3-D modeling of CT scans. By segmenting raw DICOM data, we can determine the distance from the cam lesion's surface points to the centroid of the femoral head to quantify the mean bump height, volume, and location. The resulting 3-D femoral and acetabular models will be analyzed with custom software. We then will quantify the cam lesion with 3-D parameters using a modified zoning method. The mean bump height, volume, and location on the clock face, and relative zoning will be calculated. Zonal differences will be statistically analyzed. To assess the ability of this method to predict arthroscopic findings, we will obtain preoperative CT scans for 25 patients who undergo hip arthroscopy for FAI. We will compare measurements with the method with our measurements from arthroscopy. The clinical implications of our method's measurements then will be reviewed and refined for future prospective studies. SIGNIFICANCE: We present a novel approach that can quantify a cam lesion's location and size. This method will be used to provide guidelines for the exact amount of bony resection needed from a specific location of the proximal femur. There is also potential to develop software for ease of use so this method can be more widely applied.

Kang RW; Yanke AB; Espinoza Orias AA; Orias AE; Inoue N; Nho SJ

2013-02-01

291

Localization of lesions in aphasia  

International Nuclear Information System (INIS)

Using a microcomputer, the locus and extent of the lesions, as demonstrated by computed tomography for 127 cases with various types of aphasia were superimposed onto standardized marices. The relationship between the foci of the lesions and the types of aphasia was investigated. Broca aphasics (n=39) : Since the accumulated site of the lesions highly involved the deep structures of the lower part of the precentral gyrus as well as the insula and lenticular nucleus, only 60% of the Broca aphasics had lesions on these areas. This finding has proved to have little localizing value. Wernicke aphasics (n=23) : The size of the lesion was significantly smaller than Broca's aphasia. At least 70% of the patients had the superior temporal lesions involving Wernicke's area and subcortical lesions of the superior and middle temporal gyri. Amnestic aphasics (n=18) : The size of the lesion was smaller than any other types. While there was some concentration of the lesions (maximum 40%) in the area of the subcortical region of the anterior temporal gyrus adjacent to Wernicke's area and the lenticular nucleus, the lesions were distributed throughout the left hemisphere. Amnestic aphasia was thought to be the least localizable. Conduction aphasics (n=11) : The lesions were relatively small in size. Many patients had posterior speech area lesions involving at least partially Wernicke's area. In particular, more than 80% of the conduction aphasics had lesions of the supramarginal gyrus and it's adjacent deep structures. Global aphasics (n=36) : In general, the size of the lesion was very large and 70% of the global aphasics had extensive lesions involving both Broca's and Wernicke's areas. However, there were observations showing that the lesions can be small and confined. (J.P.N.)

1984-01-01

292

Modified arthroscopic McLaughlin procedure for treatment of posterior instability of the shoulder with an associated reverse Hill-Sachs lesion.  

UK PubMed Central (United Kingdom)

Traumatic posterior shoulder dislocations are often accompanied by an impression fracture on the anterior surface of the humeral head known as a "reverse Hill-Sachs lesion". This bony defect can engage on the posterior glenoid rim and subsequently lead to recurrent instability and progressive joint destruction. We describe a new modified arthroscopic McLaughlin procedure, which allows for filling of the bony defect with the subscapularis tendon and subsequently prevents recurrence of posterior instability. This technique creates a double-mattress suture providing a large footprint for the subscapularis and a broader surface area to allow for effective tendon to bone healing. Furthermore, it obviates the need for detaching the subscapularis tendon and avoids the morbidity potentially associated with open procedures. Level of evidence V.

Martetschläger F; Padalecki JR; Millett PJ

2013-07-01

293

Bio-Oss® blocks combined with BMP-2 and VEGF for the regeneration of bony defects and vertical augmentation.  

UK PubMed Central (United Kingdom)

OBJECTIVES: The aim of this study was to evaluate the bone formation rate and osseointegration of Bio-Oss(®) blocks combined with rhBMP-2 and rhVEGF in bony defects and after vertical augmentation. MATERIAL AND METHODS: Bio-Oss(®) blocks plus rhBMP-2 (BMP), Bio-Oss(®) blocks plus rhVEGF (VEGF), or Bio-Oss(®) blocks plus rhBMP-2 and rhVEGF (BMPVEGF) were inserted in "critical size defects" (CSD) in the calvariae of adult pigs. Control defects were filled with collagen carrier (Lyostypt(®) ) plus growth factors and untreated Bio-Oss(®) blocks (CO). In a second group, Bio-Oss(®) blocks plus growth factors and untreated Bio-Oss(®) blocks were used for vertical augmentation of the calvariae. In the first group, the investigation time was 30 days, in the second group it was 30 and 60 days. The bone samples were investigated histomorphometrically, and the newly formed bone (BV/TV) was judged by microradiographic investigation. RESULTS: In the CSD model, the newly formed bone in the region of interest was not significantly different within the groups. In the second setting, the inserted bone blocks exhibited sufficient volume stability with increasing bone formation up to 9.33% ± 3.92% for BMP, 10.42% ± 1.81% for BMP/VEGF, 11.01% ± 4.78% for VEGF, and 10.02% ± 5.43% for the control group after 60 days. CONCLUSION: In the chosen setting and time frame, de novo bone formation did not increase with the additional use of growth factors.

Schmitt C; Lutz R; Doering H; Lell M; Ratky J; Schlegel KA

2013-04-01

294

Laboratory effect of Boni Protect containing Aureobasidium pullulans (de Bary) Arnoud in the control of some fungal diseases of apple fruit  

Directory of Open Access Journals (Sweden)

Full Text Available The efficacy of Aureobasidium pullulans (in the biopreparation Boni Protect) against different pathogens of apples (Botrytis cinerea, Monilinia fructigena, Penicillium expansum, and Pezicula malicorticis) was evaluated under laboratory con- ditions. The biocontrol product was applied at concentrations of 0.05%, 0.1%, and 0.5%. Fruits of apple cultivars 'Jonagold Decosta' and 'Pinova' were used. Boni Protect was very effective against B. cinerea on cv. 'Jonagold Decosta', reducing disease incidence by 55–83.8%. On 'Pinova' apples, this biological control product was the most efficient at earlier stages of the experiment. It inhibited grey mold by 65% after 5 days from inoculation and only by 14% after 20 days. On cv. 'Jonagold Decosta', Boni Protect at a concentration of 0.1% was also effective against M. fructigena, reducing brown rot by 31.4–74.5%, but its efficiency on cv. 'Pinova' was not significant. Blue mold caused by P. expansum was inhibited only slightly by the biocontrol product, while P. malicorticis proved to be the most resistant to its antagonistic abilities.

Anna Wagner; Beata Hetman; Marek Kopacki; Agnieszka Jamio?kowska; Pawe? Krawiec; Tomasz Lipa

2013-01-01

295

Application of hyperdry amniotic membrane patches without fibrin glue over the bony surface of mastoid cavities in canal wall down tympanoplasty.  

UK PubMed Central (United Kingdom)

CONCLUSION: Fibrin glue might be an inessential bioadhesive for attachment of hyperdry amniotic membrane (AM) patches in canal wall down (CWD) tympanoplasty. OBJECTIVE: To clarify the pliability and adherence capability of human hyperdry AM, the feasibility of fixing hyperdry AM without fibrin glue to the bony surface of the mastoid cavity was evaluated in CWD tympanoplasty. METHODS: This was a retrospective chart review. In seven ears of seven patients, the AM was simply attached over the bony surface of the mastoid cavity without fibrin glue (AMG(-) group). In 22 ears of 20 other patients, hyperdry AM (11 ears of 11 patients, AMG(+) group) or temporal fascia (11 ears of 9 patients, TFG(+) group) was attached over the bony surface of the mastoid cavity with fibrin glue. Times for graft epithelization were compared among the three groups. RESULTS: Complete epithelization of the mastoid cavity took place in all patients in all three groups. The mean time to complete epithelization of the graft in the AMG(-) and AMG(+) groups was significantly faster than that in the TFG(+) group (p < 0.05) and was not significantly different between the two AM groups (p > 0.05).

Kanazawa Y; Shojaku H; Okabe M; Fujisaka M; Takakura H; Tachino H; Tsubota M; Watanabe Y; Nikaido T

2012-12-01

296

Biochemistry of DNA lesions.  

UK PubMed Central (United Kingdom)

Ionizing radiation produces a range of damage types in cellular DNA. All damage types do not have the same biological significance. Here arguments are presented supporting the view that lesions in which damage is present on both strands in a local region of the DNA (locally multiply damaged sites--LMDS) will present problems for cellular repair processes. We have previously shown that lesions produced in DNA by individual OH radicals, i.e., single OH species acting alone, are ineffective in mammalian cell killing [J.F. Ward, W.F. Blakely, and E.I. Joner, Radiat. Res. 103, 383-392 (1985)]. We have similar evidence in mutagenesis studies (Ward and Calabro-Jones, unpublished data). Thus the formation of such damage by individual OH radicals formed by ionizing radiation would be similarly ineffectual. Earlier [J.F. Ward, Radiat. Res. 86, 185-195 (1981)] we suggested that OH-radical scavenging studies were consistent with the scavenging of OH radicals in volumes of high radical density, spurs, etc., i.e., in volumes which, when they overlap the DNA, will cause the production of LMDS. The individual constituent lesions of LMDS will be formed as a result of direct ionization or as a result of an OH-radical attack. Both mechanisms can lead to base damage or strand breakage. It is clear that damage in both bases of a deoxyribonucleotide pair leads to loss of base sequence information and can be repaired correctly only by accident or in a recombinational process.(ABSTRACT TRUNCATED AT 250 WORDS)

Ward JF

1985-01-01

297

Study of genital lesions  

Directory of Open Access Journals (Sweden)

Full Text Available A total of one hundred patients (75 males and 25 females) age ranged from 17-65 years with genital lesions attending the STD clinic of Bowring and LC Hospitals Bangalore constituted the study group. Based on clinical features, the study groups were classified as syphilis (39), chancroid (30), herpes genitolis (13), condylomato lato (9), LGV (7t condylomata acuminata (5), genital scabies (3), granuloma inguinole (2) and genital candidiasis (1). In 68% microbiological findings confirmed the clinical diagnosis. Of the 100 cases 13% and 2% were positive for HIV antibodies and HbsAg respectively.

Anand Kumar B; Vijaya D; Ravi R; Reddy R

2003-01-01

298

Klatskin-like lesions.  

Science.gov (United States)

Hilar cholangiocarcinoma, also known as Klatskin tumour, is the commonest type of cholangiocarcinoma. It poses unique problems in the diagnosis and management because of its anatomical location. Curative surgery in the form of major hepatic resection entails significant morbidity. About 5-15% of specimens resected for presumed Klatskin tumour prove not to be cholangiocarcinomas. There are a number of inflammatory, infective, vascular, and other pathologies, which have overlapping clinical and radiological features with a Klatskin tumour, leading to misinterpretation. This paper aims to summarise the features of such Klatskin-like lesions that have been reported in surgical literature. PMID:22811587

Senthil Kumar, M P; Marudanayagam, R

2012-06-28

299

Klatskin-like lesions.  

UK PubMed Central (United Kingdom)

Hilar cholangiocarcinoma, also known as Klatskin tumour, is the commonest type of cholangiocarcinoma. It poses unique problems in the diagnosis and management because of its anatomical location. Curative surgery in the form of major hepatic resection entails significant morbidity. About 5-15% of specimens resected for presumed Klatskin tumour prove not to be cholangiocarcinomas. There are a number of inflammatory, infective, vascular, and other pathologies, which have overlapping clinical and radiological features with a Klatskin tumour, leading to misinterpretation. This paper aims to summarise the features of such Klatskin-like lesions that have been reported in surgical literature.

Senthil Kumar MP; Marudanayagam R

2012-01-01

300

Study of genital lesions.  

Science.gov (United States)

A total of one hundred patients (75 males and 25 females) age ranged from 17-65 years with genital lesions attending the STD clinic of Bowring and LC Hospitals Bangalore constituted the study group. Based on clinical features, the study groups were classified as syphilis (39), chancroid (30), herpes genitalis (13), condylomato lato (9), LGV (7t condylomata acuminata (5), genital scabies (3), granuloma inguinole (2) and genital candidiasis (1). In 68% microbiological findings confirmed the clinical diagnosis. Of the 100 cases 13% and 2% were positive for HIV antibodies and HbsAg respectively. PMID:17642854

Anand Kumar, B H; Vijaya, D; Ravi, R; Reddy, R R

 
 
 
 
301

[Radiological diagnosis of chronic spinal cord compressive lesion at thoraco-lumbar junction  

UK PubMed Central (United Kingdom)

Radiological findings in five cases with chronic spinal cord compressive lesion at thoraco-lumbar junction were reported. Three cases had spondylosis and two cases had ossification of yellow ligament (OYL). The levels of the lesions were T12/L1 in three cases and T11/12 in two cases. Two out of three spondylotic patients had also OYL at the same level. The five cases consisted of three men and two women. The ages ranged from 42 to 60 years old with a mean age of 53 years old. Neurologically, every patient showed flaccid paresis and sensory disturbance of the legs. Two cases had sensory disturbance of stocking type. The intervals from the onset of the symptoms to the final diagnosis were 6 months, 7 years, 8 years, 11 years and 12 years. Myelography showed anterior spinal cord compression by bony spur in spondylotic patients, and posterior compression by OYL in other cases. Myelography in flexion posture disclosed the cord compression by bony spur more clearly in two out of three spondylotic patients. Delayed CT-myelography showed intramedullary filling of contrast material in two cases, which indicated degenerative change or microcavitation due to long term compression of the spinal cord. MRI was taken in three spondylotic patients and could directly show compression of the spinal cord. Difficulty in detecting abnormality at thoraco-lumbar junction on plain roentgenogram, and similarity of the symptoms to peripheral nerve disease often lead to a delay in diagnosis. The significance of dynamic myelography and delayed CT-myelography when dealing with such a lesion was discussed here.(ABSTRACT TRUNCATED AT 250 WORDS)

Koyanagi I; Isu T; Iwasaki Y; Akino M; Abe H; Tashiro K; Miyasaka K; Abe S; Kaneda K

1988-10-01

302

[Radiological diagnosis of chronic spinal cord compressive lesion at thoraco-lumbar junction].  

Science.gov (United States)

Radiological findings in five cases with chronic spinal cord compressive lesion at thoraco-lumbar junction were reported. Three cases had spondylosis and two cases had ossification of yellow ligament (OYL). The levels of the lesions were T12/L1 in three cases and T11/12 in two cases. Two out of three spondylotic patients had also OYL at the same level. The five cases consisted of three men and two women. The ages ranged from 42 to 60 years old with a mean age of 53 years old. Neurologically, every patient showed flaccid paresis and sensory disturbance of the legs. Two cases had sensory disturbance of stocking type. The intervals from the onset of the symptoms to the final diagnosis were 6 months, 7 years, 8 years, 11 years and 12 years. Myelography showed anterior spinal cord compression by bony spur in spondylotic patients, and posterior compression by OYL in other cases. Myelography in flexion posture disclosed the cord compression by bony spur more clearly in two out of three spondylotic patients. Delayed CT-myelography showed intramedullary filling of contrast material in two cases, which indicated degenerative change or microcavitation due to long term compression of the spinal cord. MRI was taken in three spondylotic patients and could directly show compression of the spinal cord. Difficulty in detecting abnormality at thoraco-lumbar junction on plain roentgenogram, and similarity of the symptoms to peripheral nerve disease often lead to a delay in diagnosis. The significance of dynamic myelography and delayed CT-myelography when dealing with such a lesion was discussed here.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3145466

Koyanagi, I; Isu, T; Iwasaki, Y; Akino, M; Abe, H; Tashiro, K; Miyasaka, K; Abe, S; Kaneda, K

1988-10-01

303

Charakterystyka grzybów izolowanych z ?o??dka u chorych z wrzodami oraz z przewlek?ym zapaleniem b?ony ?luzowej  

Directory of Open Access Journals (Sweden)

Full Text Available Wst?p: Wyst?powanie kolonizacji grzybiczej wrzodów ?o??dka dotyczy 30-50% populacji chorych z endoskopowo rozpoznanym wrzodem ?o??dka. Badania potwierdzi?y, ?e kolonizacja grzybicza b?ony ?luzowej ?o??dka wp?ywa na proces gojenia wrzodu ?o??dka. Cel pracy: Celem przeprowadzonych bada? by?a: 1) ocena wyst?powania grzybów w materia?ach klinicznych pobranych z ?o??dka od chorych z wrzodem ?o??dka oraz przewlek?ym zapaleniem b?ony ?luzowej ?o??dka, 2) okre?lenie aktywno?ci proteolitycznej izolowanych szczepów grzybów - jednego z czynników patogenno?ci Candida spp. Materia? i metody: Badaniem mitologicznym obj?to 29 chorych z wrzodem ?o??dka oraz 60 z przewlek?ym zapaleniem b?ony ?luzowej ?o??dka. Zbadano 261 próbek pobranych podczas badania endoskopowego. St??enie grzybów w materia?ach klinicznych (CFU/ml) okre?lono na podstawie badania ilo?ciowego. Identyfikacj? grzybów przeprowadzono, stosuj?c: pod?o?e Albicans ID 2 oraz testy ID 32C odczytywane w systemie ATB (bioMerieux). Do okre?lenia aktywno?ci proteolitycznej szczepów Candida zastosowano metod? spektrofotometryczn?. Pomiar absorbancji supernatantów badanych szczepów odczytywano w spektrofotometrze przy d?ugo?ci fali 380 nm. Wyniki: U 20,7% chorych z wrzodem ?o??dka oraz 5% z przewlek?ym zapaleniem b?ony ?luzowej ?o??dka stwierdzono klinicznie istotne st??enie grzybów, odpowiadaj?ce >105 CFU/ml. W badaniu mikologicznym 85 próbek pobranych od chorych z wrzodem ?o??dka wyhodowano grzyby z gatunków: C. glabrata (23%), C. albicans (21,9%), C. kefyr (2,3%), C. krusei (1.1%). U osób z przewlek?ym zapaleniem b?ony ?luzowej ?o??dka C. glabrata izolowano tylko w 2,8%, natomiast C. albicans w 15.7%. Szczepy charakteryzowa?y si? ró?n? aktywno?ci? proteolityczn?. Szczepy C. glabrata wykaza?y silniejsze w?a?ciwo?ci proteolityczne w porównaniu do C. albicans. Wnioski: Wyniki uzyskane z przeprowadzonych bada? mog? by? wykorzystane w epidemiologii oraz terapii zaka?e? grzybiczych.

Alicja Budak; Danuta Trojanowska; Ma?gorzata Zwoli?ska-Wcis?o; Anna Bucka; Bogus?awa Borecka

2002-01-01

304

[Gastric mucosa as a target in duodenogastric reflux: assessment of lesions with the system of indices  

UK PubMed Central (United Kingdom)

AIM: To characterize gastric mucosa lesion in patients with duodenogastric reflux (DGR) using an original system of indices evaluating general pathological processes in gastric mucosa. MATERIAL AND METHODS: The trial enrolled 109 patients with chronic gastritis (CG) in combination with opisthorchiasis. These were divided into 2 groups: CG patients with DGR (group 1, n = 58), CG patients free of DGR (group 2, n = 51). Thirty patients with chronic acalculous cholecystitis served control. All the patients have undergone fibrogastroduodenoscopy with biopsy from the antral part of the stomach and its body. To detail morphological picture of the gastric mucosa a number of additional indices were used characterizing exudative inflammation, productive inflammation, atrophic, sclerotic, immunopathological, dysregeneratory processes. RESULTS: Semiquantitative analysis of gastric mucosa in chronic opisthorchiasis patients with DGR by the above indices showed a significant prevalence of exudative (p < 0.05) and productive (p < 0.01) inflammations in the antrum over those in the gastric body. Comparison of the indices in the patients with and without DGR revealed significant differences in activity of exudative inflammation (p < 0.05), dysregeneratory (p < 0.05) and atrophic (p < 0.001) processes in gastric antrum and dysregeneratory and atrophic processes in the gastric body (p < 0.01). CONCLUSION: The indices contribute to more precise assessment of structural shifts occurring in gastric mucosa which is the target for DGR.

Eremeev SI; Turilova NS; Akhmedov VA

2002-01-01

305

Case report 513: Tuberculosis of manubrium serni  

Energy Technology Data Exchange (ETDEWEB)

The case of a 32-year-old Turkish woman was presented showing soft tissue swelling over the manubrium and surrounding sclerotic changes. A CT-guided needle biopsy in the area of the lesion demonstrated mycobacterium tuberculosis. The author stressed that tuberculous infection of the manubrium is extremely rare. The literature was reviewed, confirming this statement. It was emphasized by the author that the possibility of tuberculosis must be considered in any immigrant from the Middle East, Africa or Asia presenting with an unusual bony lesion.

Rajah, R.

1989-01-01

306

CT-guided percutaneous core needle biopsy in deep seated musculoskeletal lesions: a prospective study of 128 cases  

International Nuclear Information System (INIS)

Although large lesions of the limbs can easily be biopsied without image guidance, lesions in the spine, paraspinal area and pelvis are difficult to target, and benefit from CT guidance to improve the accuracy of targeting the lesion for biopsy purposes. A prospective study of CT-guided core needle biopsies for deep-seated musculoskeletal lesions was conducted at a referral cancer institute over a 4-year period with the aim of assessing the safety and efficacy of the procedure. From January 2000 to December 2003, 136 consecutive CT-guided biopsy sessions were undertaken for musculoskeletal lesions in 128 patients comprising 73 males and 55 females. The following data was recorded in all patients: demographic data, suspected clinicoradiological diagnosis, data related to core biopsy session (date, site, approach, total time required in minutes, number of cores, surgeon satisfaction with adequacy of cores), patient discomfort, complications, histopathology report and number of further sessions if material obtained during the first biopsy session was not confirmatory. The sample obtained during the biopsy session was considered inconclusive if, in the opinion of the pathologist, inadequate or non-representative tissue had been obtained. The diagnosis was considered inaccurate if the final histopathological diagnosis did not match with the biopsy diagnosis, or if subsequent clinicoradiological evaluation at follow up did not correlate with the biopsy diagnosis in those patients who were treated with modalities other than surgery. In 121 patients, a single session was sufficient to obtain representative material, whilst for six patients two sessions, and for one patient three sessions were necessary. The time taken for biopsy, including the pre-biopsy CT examination time, varied from 15 min to 60 min (median 30 min). For 110 bony lesions 116 sessions were required, and for 18 soft-tissue lesions 20 sessions were required. 108 biopsy sessions yielded a diagnosis, whilst 28 were inconclusive (diagnostic yield of 79.41%). Of 108 diagnostic biopsies, five were considered inaccurate (accuracy rate of 95.37%). The overall diagnostic yield and accuracy rate for bony lesions were 81.03% and 95.74%; and those for soft-tissue lesions were 70% and 92.85%. There were two complications with no permanent sequelae. CT-guided core needle biopsy is a safe, easy, and effective technique for the evaluation of deep-seated musculoskeletal lesions, with a high rate of diagnostic yield and accuracy. It facilitates definitive therapy without the patient having to undergo a major surgical procedure for diagnosis. (orig.)

2006-01-01

307

L’art du vitrail en France au temps de la reconstruction et de la croissance. Note sur les fonds Hébert-Stevens - Bony conservés aux Archives nationales du monde du travail (Fonds n° 2002 001)  

Directory of Open Access Journals (Sweden)

Full Text Available Cet article a pour objet de présenter brièvement le fonds de l’atelier Hébert-Stevens - Bony, entré aux Archives nationales (Archives nationales du monde du travail, Roubaix) en 2002

Christian Hottin

2009-01-01

308

Lesiones traumáticas: Conducta odontológica  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish En la cavidad bucal se pueden producir una variedad de lesiones de diferente etiología, por ello es muy importante que el odontólogo las identifique y conozca las consecuencias que ocasiona si no se previenen o tratan a tiempo. Se funda como premisa que el cuidado periodontal es, en esencia, labor del odontólogo general y que éste no puede pasar por alto la responsabilidad de proveer atención a todos los pacientes. La incidencia excesivamente elevada de los problemas (more) periodontales entre la población, dificulta que un número reducido de especialistas los pueda enfrentar. Asimismo, el estrecho vínculo entre los tratamientos dentales restaurativos y los regímenes periodontales hace muy importante que el odontólogo general disponga de conocimientos a fondo sobre periodoncia. En la cavidad bucal se producen variedades de lesiones de origen traumático ya sea por injurias químicas, físicas y térmicas estás representan una urgencia en Odontología. El propósito de este reporte es describir las diferentes presentaciones clínicas de dicha patología, su etiología, diagnósticos diferenciales y diferentes métodos de tratamiento, para valorar sus complicaciones y cuidados postoperatorios. Para ello se realizó basado en los lineamientos de la investigación descriptiva documental, una revisión de la literatura nacional e internacional. Abstract in english A variety of different etiologies pathologies can affect the oral cavity, due to this reason, dentists must be able to identify them and their consequences if they are not treated on time. It is primordial for the general practitioner dentists the periodontal care of their patients. Among the population the periodontal diseases are very common and only a reduced number of specialists can treat them. The close relation between restorative dental treatments and periodontal (more) treatment procedures lead to the tendency that de general practitioner has enough knowledge in the periodontal field. Among the variety of pathologic entities that affect the oral mucosa, that presents as ulcer and are really Traumatic lesions in its different types chemical injury, physical injury, thermal injury It is considered one of the emergencies in dentistry. Dentist must be able to recognize and treat them. The purpose of this research is to describe the possible etiologic agents, clinical features and treatment of this disease and also to recommend the multidisciplinary attention to these patient. For this paper was made a study based on the lineaments of the descriptive documental research, mainly with scientific bibliographic references literature national and international.

Salinas M, Yuni J; Millán I, Ronald E; León M, Juan C

2008-01-01

309

[Transverse lesion of the cord syndrome in chondrodystrophic dwarfs (author's transl)].  

Science.gov (United States)

More than 70 transverse lesion of the cord syndromes in chondrodystrophic dwarfs have been described in the literature. 43 of these were adequately described and/or accessible for the authors. In 22 cases, a mechanical cause (including 14 lesions of the intervertebral disk) was directly responsible and, in 14 cases, no direct spinal cord suppression was found. In the latter group, 10 had a negative myelography, 3 positive and 1 case myelography was not performed. Of the 12 laminectomized cases, only 3 made a good recovery, 4 showed severe deterioration and 2 conservatively treated cases (including the case described here) were clearly improved. Of the 16 laminectomized cases with limited mechanical impediment, 8 showed good results, 3 indifferent and 5 unknown. The cause of the vascular myleopathy was assumed to be a combination of the narrowness of the bony vertebral canal and an increasing kyphotic process. The authors suggest that laminectomy for tranverse lesion of the cord syndrome in dwarfs should be made only after several controls and an established stop correlating with the location of the neurological lesions. We reject decompression laminectomy for vascular myleopathy because of the already endangered vascular situation and the poor results. We prefer orthopedic measures. PMID:997744

Bösch, P; Reisner, T

1976-10-01

310

[Transverse lesion of the cord syndrome in chondrodystrophic dwarfs (author's transl)  

UK PubMed Central (United Kingdom)

More than 70 transverse lesion of the cord syndromes in chondrodystrophic dwarfs have been described in the literature. 43 of these were adequately described and/or accessible for the authors. In 22 cases, a mechanical cause (including 14 lesions of the intervertebral disk) was directly responsible and, in 14 cases, no direct spinal cord suppression was found. In the latter group, 10 had a negative myelography, 3 positive and 1 case myelography was not performed. Of the 12 laminectomized cases, only 3 made a good recovery, 4 showed severe deterioration and 2 conservatively treated cases (including the case described here) were clearly improved. Of the 16 laminectomized cases with limited mechanical impediment, 8 showed good results, 3 indifferent and 5 unknown. The cause of the vascular myleopathy was assumed to be a combination of the narrowness of the bony vertebral canal and an increasing kyphotic process. The authors suggest that laminectomy for tranverse lesion of the cord syndrome in dwarfs should be made only after several controls and an established stop correlating with the location of the neurological lesions. We reject decompression laminectomy for vascular myleopathy because of the already endangered vascular situation and the poor results. We prefer orthopedic measures.

Bösch P; Reisner T

1976-10-01

311

Coronary bifurcation lesions.  

Science.gov (United States)

Treatment of coronary bifurcation lesions represents a challenging area in interventional cardiology, but recent advances in percutaneous coronary interventions have led to a dramatic increase in the number of patients successfully treated percutaneously. When compared with nonbifurcation interventions, bifurcation interventions have a lower rate of procedural success, higher procedural costs, longer hospitalization, and a higher rate of clinical and angiographic restenosis. The recent introduction of drug-eluting stents has resulted in a lower event rate and reduction of main vessel restenosis compared with historical controls. Side branch ostial residual stenosis and long-term restenosis remain a problem, however. Although stenting the main vessel with provisional side branch stenting seems to be the prevailing approach, in the era of drug-eluting stents, various two stent techniques have emerged to allow stenting of the large side branch also. PMID:16781940

Sharma, Samin K; Kini, Annapoorna S

2006-05-01

312

[Serious jaw osteolytic lesions].  

Science.gov (United States)

Among oral and maxillofacial diseases, the maxillary osteolytic lesions constitute a rich and investigated field to define the more appropriate diagnosis and treatment. In the maxillary region, the same tumors of the other bones (osteogenic sarcoma, chondroma, etc.) cause found together with tumors and dysembryoplasias connected with the teeth development (ameloblastoma, odontoma, odontogenic myxoma, etc.). Moreover in the medullary spaces of the bones, there are reticular and hematopoietic cells that are connected with different diseases (leucemia, myeloma, lymphoma, etc.). What's more, due to the possible presence of pseudotumors (fibrous dysplasia, giant cell tumor, etc.) and metastases of tumors of other regions (breast, lung, prostate gland, etc.), the diagnosis of this disease could be difficult. In this paper the more important pictures of this disease, that due to its recurrence or malignity needs an accurate diagnosis by imaging like CT, CT-3D, MR, etc, are analyzed. The more suitable surgical approach is presented, according to the forms of the disease. PMID:12686916

Junquera, L; Corbacelli, A; Ascani, G; Iacomino, E

313

Intravascular lesions of the hand  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Introduction Intravascular lesions of the hand comprise reactive and neoplastic entities. The clinical diagnosis of such lesions is often difficult, and usually requires pathologic examination. We present the largest series to date of intravascular lesions affecting the hand. Methods A retrospective review of intravascular (arterial and venous) lesions involving the hand was conducted. Data regarding clinicopathologic findings were analyzed. Results We identified 10 patients with intravascular lesions of their hands including thromboemboli (n = 3), reactive intravascular conditions such as papillary endothelial hyperplasia or Masson's tumor (n = 2) and fasciitis (n = 1), as well as vascular neoplasms including pyogenic granuloma (n = 2) and angioleiomyoma (n = 2). Conclusion Blood vessel injury and/or venous thrombosis may predispose to several intravascular lesions of the hand. Recognition of reactive entities from neoplastic conditions is important.

Pantanowitz Liron; Duke Wayne H

2008-01-01

314

Lesion procedures in psychiatric neurosurgery.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Lesion procedures for psychiatric indications have a history that spans more than a century. This review provides a brief history of psychiatric surgery and addresses the most recent literature on lesion surgery for the treatment of anxiety and mood disorders. METHODS: Relevant data described in publications from the early 1900s through the modern era regarding lesion procedures for psychiatric indications, both historical and current use, are reported. RESULTS: The early procedures of Burkhardt, Moniz, and Freeman are reviewed, followed by descriptions of the more refined techniques of Leksell, Knight, Foltz, White, and Kelly. The application of lesion procedures to obsessive-compulsive disorder, mood disorders, and addiction are discussed. CONCLUSIONS: Lesioning procedures have informed modern deep brain stimulation targets. Recent lesioning studies demonstrate the efficacy and durability of these procedures in severely disabled patients. Judicious application of these techniques should continue for appropriately selected patients with severe, refractory psychiatric disorders.

Patel SR; Aronson JP; Sheth SA; Eskandar EN

2013-09-01

315

Air CT cisternography in cases with retrolabyrinthine lesion  

International Nuclear Information System (INIS)

Imaging of the cerebellopontine angle structures by means of air CT cisternography was studied in cases with suspected retrolabyrinthine lesions. The method of air CT cisternography in our study was characterized by air infusion through a suboccipital route and by imaging of both cerebellopontine angles in one study. Ninety cases have been studied so far. Four cases of small acoustic tumors, including two cases of intracanalicular tumors, were found. Additionally, one case of small meningioma in the porus was detected. The percentage of the detection of small acoustic tumors in our series was significantly low. However, various abnormalities other than neoplasms were revealed. An enlargement of the acoustic canal without a tumor was found in five cases; this abnormality was usually bilateral. This structural abnormality corresponds to the patulous canal or dural ectasia of the canal described in the previous literature, which was believed to be one of characteristics of bony changes in Recklinghausen's disease. Only one case in our series, however, had the definite stigmata of Recklinghausen's disease. The present authors designate this canal enlargement ''empty meatus''; it seems to be a new clinical entity. An irregular thickening of the nerve and a nodular appearance of the nerve in the canal were found in the case of Recklinghausen's disease. A diagnosis of localized arachnoiditis was made in three cases, and that of a primary atrophy of the acoustic nerve, in one case. (author)

1986-01-01

316

Biopsy of the pigmented lesions.  

UK PubMed Central (United Kingdom)

Although new technologies are becoming available to aid in diagnosis, the skin biopsy continues to be the fundamental tool of the dermatologist to evaluate the nature of a pigmented lesion. There are 3 major techniques for the biopsy of a pigmented lesion: shave biopsy, punch/incisional biopsy, and excisional biopsy. This article discusses when to biopsy a pigmented lesion and reviews the different biopsy techniques, with reference to specific clinical scenarios.

Silverstein D; Mariwalla K

2012-07-01

317

Scales and dermal skeletal histology of an early bony fish Psarolepis romeri and their bearing on the evolution of rhombic scales and hard tissues.  

UK PubMed Central (United Kingdom)

Recent discoveries of early bony fishes from the Silurian and earliest Devonian of South China (e.g. Psarolepis, Achoania, Meemannia, Styloichthys and Guiyu) have been crucial in understanding the origin and early diversification of the osteichthyans (bony fishes and tetrapods). All these early fishes, except Guiyu, have their dermal skeletal surface punctured by relatively large pore openings. However, among these early fishes little is known about scale morphology and dermal skeletal histology. Here we report new data about the scales and dermal skeletal histology of Psarolepis romeri, a taxon with important implications for studying the phylogeny of early gnathostomes and early osteichthyans. Seven subtypes of rhombic scales with similar histological composition and surface sculpture are referred to Psarolepis romeri. They are generally thick and show a faint antero-dorsal process and a broad peg-and-socket structure. In contrast to previously reported rhombic scales of osteichthyans, these scales bear a neck between crown and base as in acanthodian scales. Histologically, the crown is composed of several generations of odontodes and an irregular canal system connecting cylindrical pore cavities. Younger odontodes are deposited on older ones both superpositionally and areally. The bony tissues forming the keel of the scale are shown to be lamellar bone with plywood-like structure, whereas the other parts of the base are composed of pseudo-lamellar bone with parallel collagen fibers. The unique tissue combination in the keel (i.e., extrinsic Sharpey's fibers orthogonal to the intrinsic orthogonal sets of collagen fibers) has rarely been reported in the keel of other rhombic scales. The new data provide insights into the early evolution of rhombic (ganoid and cosmoid) scales in osteichthyans, and add to our knowledge of hard tissues of early vertebrates.

Qu Q; Zhu M; Wang W

2013-01-01

318

Thorotrast-associated gliosarcoma. Including comments on thorotrast use and review of sequelae with particular reference to lesions of the central nervous system  

International Nuclear Information System (INIS)

[en] The occurrence of a glioblastoma with sarcoma, a gliosarcoma, in the left frontal-temporal area of a 49-year-old woman with a history of Thorotrast exposure, is described. Thorotrast-laden histiocytes and free Thorotrast material were found in both components of the tumor. An overlying, adherent dural cranial lesion was found to contain massive deposits of Thorotrast embedded in a dense fibrotic and sclerotic stroma with focal calcification. These features are typical of Thorotrastoma. Thorotrast stains greenish-brown with hematoxylin and eosin and appears as refractile granular particles of relatively uniform size either within histiocytes or as free material. The radioactivity of the deposits was confirmed through the use of a scintillation counter, and thorium 232 was definitively identified though the use of scanning electron microscopy with energy-dispersive X-ray analysis. Immunohistochemical studies of the tumor demonstrated glial fibrillary acid protein (GFAP) immunoreactivity in areas of glioma and focal vimentin and actin immunoreactivity in areas of sarcoma. Thorotrast-associated lesions of the central nervous system (CNS) are infrequently reported, and a Thorotrast-associated gliosarcoma has not yet been reported. The use of Thorotrast, its radiobiology, and sequelae are reviewed with particular emphasis on lesions occurring in the CNS. 52 references

1988-07-01

319

Thorotrast-associated gliosarcoma. Including comments on thorotrast use and review of sequelae with particular reference to lesions of the central nervous system  

Energy Technology Data Exchange (ETDEWEB)

The occurrence of a glioblastoma with sarcoma, a gliosarcoma, in the left frontal-temporal area of a 49-year-old woman with a history of Thorotrast exposure, is described. Thorotrast-laden histiocytes and free Thorotrast material were found in both components of the tumor. An overlying, adherent dural cranial lesion was found to contain massive deposits of Thorotrast embedded in a dense fibrotic and sclerotic stroma with focal calcification. These features are typical of Thorotrastoma. Thorotrast stains greenish-brown with hematoxylin and eosin and appears as refractile granular particles of relatively uniform size either within histiocytes or as free material. The radioactivity of the deposits was confirmed through the use of a scintillation counter, and thorium 232 was definitively identified though the use of scanning electron microscopy with energy-dispersive X-ray analysis. Immunohistochemical studies of the tumor demonstrated glial fibrillary acid protein (GFAP) immunoreactivity in areas of glioma and focal vimentin and actin immunoreactivity in areas of sarcoma. Thorotrast-associated lesions of the central nervous system (CNS) are infrequently reported, and a Thorotrast-associated gliosarcoma has not yet been reported. The use of Thorotrast, its radiobiology, and sequelae are reviewed with particular emphasis on lesions occurring in the CNS. 52 references.

Wargotz, E.S.; Sidawy, M.K.; Jannotta, F.S.

1988-07-01

320

A combined bony and soft-tissue tarsal stabilization procedure (Grice-Schede) for hindfoot valgus in children with cerebral palsy.  

UK PubMed Central (United Kingdom)

This study deals with a combined bony and soft-tissue procedure (Grice-Schede) for the treatment of pes (equino) planovalgus in children suffering from cerebral palsy. Results of 43 treated feet in 28 children were assessed clinically and radiologically at a mean follow-up time of 6.7 years (range from 0.6 years to 13.8 years). In all, 58.1% excellent or good results, 14.0% satisfactory and 27.9% poor results were found. The procedure can be recommended for patients with hemiplegic and diplegic conditions. It is not suited for patients with total body involvement.

Hamel J; Kissling C; Heimkes B; Stotz S

1994-01-01

 
 
 
 
321

Modeling of the bony pelvis from MRI using a multi-atlas AE-SDM for registration and tracking in image-guided robotic prostatectomy.  

UK PubMed Central (United Kingdom)

A fundamental challenge in the development of image-guided surgical systems is alignment of the preoperative model to the operative view of the patient. This is achieved by finding corresponding structures in the preoperative scans and on the live surgical scene. In robot-assisted laparoscopic prostatectomy (RALP), the most readily visible structure is the bone of the pelvic rim. Magnetic resonance imaging (MRI) is the modality of choice for prostate cancer detection and staging, but extraction of bone from MRI is difficult and very time consuming to achieve manually. We present a robust and fully automated multi-atlas pipeline for bony pelvis segmentation from MRI, using a MRI appearance embedding statistical deformation model (AE-SDM). The statistical deformation model is built using the node positions of deformations obtained from hierarchical registrations of full pelvis CT images. For datasets with corresponding CT and MRI images, we can transform the MRI into CT SDM space. MRI appearance can then be used to improve the combined MRI/CT atlas to MRI registration using SDM constraints. We can use this model to segment the bony pelvis in a new MRI image where there is no CT available. A multi-atlas segmentation algorithm is introduced which incorporates MRI AE-SDMs guidance. We evaluated the method on 19 subjects with corresponding MRI and manually segmented CT datasets by performing a leave-one-out study. Several metrics are used to quantify the overlap between the automatic and manual segmentations. Compared to the manual gold standard segmentations, our robust segmentation method produced an average surface distance 1.24±0.27mm, which outperforms state-of-the-art algorithms for MRI bony pelvis segmentation. We also show that the resulting surface can be tracked in the endoscopic view in near real time using dense visual tracking methods. Results are presented on a simulation and a real clinical RALP case. Tracking is accurate to 0.13mm over 700 frames compared to a manually segmented surface. Our method provides a realistic and robust framework for intraoperative alignment of a bony pelvis model from diagnostic quality MRI images to the endoscopic view.

Gao Q; Chang PL; Rueckert D; Ali SM; Cohen D; Pratt P; Mayer E; Yang GZ; Darzi A; Edwards PE

2013-03-01

322

Precancerous colorectal lesions (Review).  

UK PubMed Central (United Kingdom)

Colorectal cancer (CRC) is a common and often lethal tumor. Over the last 25 years, remarkable progress has been made in understanding its biological and molecular features and in elucidating the steps involved in colon carcinogenesis. This, in turn, has led to a more rational and effective clinical approach to the treatment of CRC. While colorectal adenoma is the most frequent precancerous lesion, other potentially premalignant conditions, including chronic inflammatory bowel diseases and hereditary syndromes, such as familial adenomatous polyposis, Peutz-Jeghers syndrome and juvenile polyposis, involve different sites of the gastrointestinal tract with an overall incidence of less than 5%. In all such cases, disease recognition at an early stage is essential to devise suitable preventive cancer strategies. These topics are addressed in this review, along with the most important epidemiological, pathogenetic and clinical features that lead to malignant transformation. Novel biomarkers for early cancer prediction, detection, prognostic evolution, and the response to treatment are critically assessed as well. Continued improvements in our knowledge of the molecular basis of CRC and the transfer of this information into daily clinical practice will reduce the burden of this disease.

Conteduca V; Sansonno D; Russi S; Dammacco F

2013-10-01

323

Precancerous colorectal lesions (Review).  

Science.gov (United States)

Colorectal cancer (CRC) is a common and often lethal tumor. Over the last 25 years, remarkable progress has been made in understanding its biological and molecular features and in elucidating the steps involved in colon carcinogenesis. This, in turn, has led to a more rational and effective clinical approach to the treatment of CRC. While colorectal adenoma is the most frequent precancerous lesion, other potentially premalignant conditions, including chronic inflammatory bowel diseases and hereditary syndromes, such as familial adenomatous polyposis, Peutz-Jeghers syndrome and juvenile polyposis, involve different sites of the gastrointestinal tract with an overall incidence of less than 5%. In all such cases, disease recognition at an early stage is essential to devise suitable preventive cancer strategies. These topics are addressed in this review, along with the most important epidemiological, pathogenetic and clinical features that lead to malignant transformation. Novel biomarkers for early cancer prediction, detection, prognostic evolution, and the response to treatment are critically assessed as well. Continued improvements in our knowledge of the molecular basis of CRC and the transfer of this information into daily clinical practice will reduce the burden of this disease. PMID:23900573

Conteduca, Vincenza; Sansonno, Domenico; Russi, Sabino; Dammacco, Franco

2013-07-29

324

[Method of superimposing the angiographically located supratentorial lesion on the scalp prior to craniotomy  

UK PubMed Central (United Kingdom)

One of the important points in operation of the intracranial supratentorial lesion is appropriate site and size of bony window made by craniotomy and this matter is also important first step in procedure of craniotomy. On the other hand, the site and size of bony window made in craniotomy for supratentorial lesion has relationship with perfectibility of operation. The detail intracranial situation and extent of supratentorial lesion is decided from the datas of various examinations and the findings in cerebral angiogram give a most important and valuable information to the neurosurgeon at present. The neurosurgeons used to decide the area of craniotomy from the findings of cerebral angiogram but there are some difficulty in transfer of findings related with situation of supratentorial lesion in angiogram to the patient's scalp, because the film of cerebral angiography is a projected picture of spheric head by X-ray to the plane. The author devised the planning method of site and size of bony window in craniotomy by transfer the location and extent of supratentorial lesion in cerebral angiogram to the patient's scalp and the author have been recognized for the past five years that this method is simple one and has clinical accuracy. The principle of the author's method are as follows. The film of cerebral angiography in lateral projection and the patient's scalp are divided into nine parts by same manner and the relation of the site and extent of lesion in cerebral angiogram with divided parts transfer to the division of the patient's scalp under special care to make minimize errors due to use the cerebral angiogram which is picture made by projection in a plane from spheric intracranial supratentorial space. Five points and seven lines are used to divide the film of cerebral angiography and the patient's scalp. Five divide points are most upper part of margin of external acoustic meatus, most posterior edge of auricle, upper, lower and lateral edge of orbit. The following divide lines are drawn by use of these five divide points. Two horizontal lines are eye-ear horizontal line and superior eye horizontal line. Three vertical line are external acoustic meatus vertical line, auricular vertical line and temporal orbital margine vertical line. Two oblique lines are anterior and posterior oblique lines. The film of lateral cerebral angiography and patient's scalp are divided into nine parts by these seven divide lines. In the areas above the superior eye horizontal line, following procedure for correction of error due to transfer the point of X-ray film to the patient's scalp is needed because of strong curved brain surface. One end of celluloid or steel scale place closely with the scalp below the superior eye horizontal line and the other end of scale make freely from curved scalp surface. The point of lesion on the divide line of X-ray film marks at correspond point on the scale...

Miyazaki Y

1976-07-01

325

Relations among traumatic subdural lesions.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Acute subdural hematoma (ASDH), chronic subdural hematoma (CSDH) and subdural hygroma (SDG) occur in the subdural space, usually after trauma. We tried to find a certain relationship among these three traumatic subdural lesions in 436 consecutive patients. We included all subdural lesions regardless...

Lee, K. S.; Doh, J. W.; Bae, H. G.; Yun, I. G.

326

Mallory-Weiss lesions  

DEFF Research Database (Denmark)

Introduction: Malory-Weiss syndrome (MW) has been known since 1929. Only few studies exist which focus on the prognosis of the lesion. No Danish MW data are available. The purpose of the study was to describe the demographics of patients admitted with an MW to a Danish surgical unit during a 5-year period and to investigate the prognosis of these patients. Material and methods: Data from the patient records of 49 patients with endoscopically verified MW admitted through a five-year period were analysed. At follow-up, 35 patients were alive and contacted. A total of 29 responded. The mean time to follow-up from admittance was 42.7 months (range: 10.1-77.1). Results: Haemostasis was achieved in all 49 patients. Sixteen received active therapy during the endoscopic procedure. Haemoglobin at admitance was lower (p = 0.008), the presence of bleeding stigmata higher (p < 0.0001) and the number of patients receiving blood transfusion higher (p = 0.01) among those receiving active therapy than among the group receiving no therapy at the time of their endoscopy. At follow-up, 50% of those receiving active therapy were dead (eight of 16) compared with 18% (six of 33) in the no-therapy group (p = 0.02). In the follow-up period, 10% of the patients admitted with an MW were re-admitted for a new gasatrointestinal bleeding. Conclusion: Our data suggests that an attitude change is needed toward MW with bleeding stigmata. The course of the disease may not be as benign as generally believed. Further prospective studies designed to resolve this matter are needed.

Lange, J.; Jensen, Lone Susanne

2010-01-01

327

Pain in osteochondral lesions.  

UK PubMed Central (United Kingdom)

Pain is the key symptom of patients suffering from osteochondral lesions (OCLs) of the ankle joint. Routine radiographic imaging methods for diagnosis and staging of OCL fail to visualize the pain-inducing focus within the joint. SPECT-CT (Single-photon emission computed tomography-computed tomography) is a new hybrid imaging technique allowing exact digital fusion of scintigraphic and computer tomographic images. This allows precise localization and size determination of an OCL within the joint. Using this novel imaging method, we conducted a study to evaluate the correlation between pathological uptake within an OCL and pain experienced by patients suffering from this condition; 15 patients were assessed in the orthopaedic ambulatory clinic for unilateral OCL of the ankle joint. Pain status was measured with the Visual Analogue Scale (VAS). A SPECT-CT was performed. All patients underwent CT-guided ankle injection with a local anesthetic and iodine contrast medium. The VAS score assessed immediately postinfiltration was compared with the preinterventional VAS score obtained in the outpatient clinic. Pain relief was defined as a reduction of the VAS score to ?50% of the preinterventional score, if expected immediately after infiltration. Pain relief was found in all 15 patients. The results of our study show that there is a highly significant correlation between pain and pathological uptake seen on SPECT-CT, indicating that pathologically remodeled bone tissue is an important contributor to pain in OCL. Adequate addressing of involved bone tissue needs to be taken into consideration when choosing a surgical treatment method.

Wiewiorski M; Pagenstert G; Rasch H; Jacob AL; Valderrabano V

2011-04-01

328

Pain in osteochondral lesions.  

Science.gov (United States)

Pain is the key symptom of patients suffering from osteochondral lesions (OCLs) of the ankle joint. Routine radiographic imaging methods for diagnosis and staging of OCL fail to visualize the pain-inducing focus within the joint. SPECT-CT (Single-photon emission computed tomography-computed tomography) is a new hybrid imaging technique allowing exact digital fusion of scintigraphic and computer tomographic images. This allows precise localization and size determination of an OCL within the joint. Using this novel imaging method, we conducted a study to evaluate the correlation between pathological uptake within an OCL and pain experienced by patients suffering from this condition; 15 patients were assessed in the orthopaedic ambulatory clinic for unilateral OCL of the ankle joint. Pain status was measured with the Visual Analogue Scale (VAS). A SPECT-CT was performed. All patients underwent CT-guided ankle injection with a local anesthetic and iodine contrast medium. The VAS score assessed immediately postinfiltration was compared with the preinterventional VAS score obtained in the outpatient clinic. Pain relief was defined as a reduction of the VAS score to ?50% of the preinterventional score, if expected immediately after infiltration. Pain relief was found in all 15 patients. The results of our study show that there is a highly significant correlation between pain and pathological uptake seen on SPECT-CT, indicating that pathologically remodeled bone tissue is an important contributor to pain in OCL. Adequate addressing of involved bone tissue needs to be taken into consideration when choosing a surgical treatment method. PMID:21321364

Wiewiorski, Martin; Pagenstert, Geert; Rasch, Helmut; Jacob, Augustinus Ludwig; Valderrabano, Victor

2011-02-14

329

Musculo-nasomucosal unit with complete lateral bony freeing and medial rotation for ideal C-shape restoration and retropositioning of the levator veli palatini.  

UK PubMed Central (United Kingdom)

No definitive procedure for cleft repair has been identified yet as the gold standard. Accordingly, this work tried to appraise the hypothesis that if the bony detachment and full retropositioning of the levator veli palatini muscle can ideally present an anatomical C-shape muscular sling restoration and if this is accompanied with pushback palatoplasty, would this present a better result in terms of tissue fistulation and phonetic impairment? A series of 74 different degrees of palatal clefts were operated by pushback palatoplasty combined with a modified approach of the levator vili palatini. This muscle was dissected only from the oral mucosa while kept attached to the nasal one as a musculo-nasomucosal unit. This unit was completely detached from the bony margin of the hard palate and then medially rotated and retropositioned in a typical C-shape mobile sling. Evaluations included suture line assessment and fistula development, and following the child's need for speech therapy. There were no intraoperative complications. Definite anterior fistulae with nasal air and foot leakage were observed in 2 cases. Four cases had postoperative velopharyngeal incompetence with a need for speech therapy. Tension-free closure, lower risk of fistula, good restoration of velopharyngeal functions, ability to be performed on all cleft types, ability to provide a good intraoperative exposure, and being a single stage seem to be the most important advantages of this unpublished technique.

El-Shazly M

2012-11-01

330

Temporary removal of the posterior bony canal wall with reconstruction using microplate osteosynthesis in cholesteatoma surgery: a case series and description of the technique.  

UK PubMed Central (United Kingdom)

We describe the surgical technique of temporary removal of the posterior auditory canal wall with reconstruction and report the outcome of using this technique as a treatment method for cholesteatoma in a case series. In 32 cases of cholesteatoma surgery a technique of temporary removal of the posterior bony wall was applied. During primary surgery the posterior auditory canal wall was removed using an oscillating saw. For the purpose of reconstruction, the canal wall was repositioned and fixed using two titanium microplates (n = 26). In case the canal wall could not be reconstructed with osteosynthesis, either glass-ionomeric cement (BioCem™) was used for fixation (n = 4) or fibrin glue (Tissucol™) (n = 2) to support the posterior wall. The outcome includes the healing process in the first postoperative month, the absence of residual or recurrent disease and the successful reconstruction of the posterior auditory canal wall as evaluated during second-look surgery. When microplates where used, we saw healing problems of the canal skin in about 4 % of patients. Recurrent cholesteatoma was found in 4 cases (14 %), residual cholesteatoma in 8 ears (25 %). In the osteosynthesis group, successful reconstruction was achieved in 25 patients (96 %). In 3 out of 4 patients of the glass-ionomeric cement group (75 %) excessive granulation tissue developed with extensive bony lysis. Temporary removal of the posterior auditory canal wall offers potential for the control of cholesteatoma. Our first results suggest that osteosynthesis allows for a good anatomical and functional reconstruction.

Van der Gucht K; Van Rompaey V; Vanderveken O; Van de Heyning P; Claes J

2013-08-01

331

MHC class I presentation and regulation by IFN in bony fish determined by molecular analysis of the class I locus in grass carp.  

UK PubMed Central (United Kingdom)

Beyond their sequences, little is known regarding MHC class I presentation and regulation by IFN in bony fish. In this work, the class I locus (Ctid-UBA) was isolated from a grass carp fosmid library, and its polymorphisms and tissue expression were investigated. The Ctid-UBA and Ctid-beta2-microglobulin genes then were expressed and refolded, and tetramer techniques were used to identify the CTL response. The interaction between grass carp type I IFN and Ctid-UBA genes was investigated. Two fosmids coding for Ctid-UBA *0101 and Ctid-UBA *0201 genes were sequenced. The SXY box and IFN-stimulated regulatory element motifs were located from the start codons to -800 bp in Ctid-UBA. A Southern blot showed three to four bands, suggesting that grass carp contains at least three class I loci. In addition, the Ctid-UBA allelic genes are expressed in all tissue of grass carp. The three-dimensional structure of Ctid-UBA *0102 showed that the peptide-binding domain was formed by the alpha1 and alpha2 domains, which could bind several nonapeptides of grass carp hemorrhagic virus. There were 1.60% more PE-positive cells in P1(QPNEAIRSL)-immunized fish than in blank and adjuvant control groups. Additionally, recombinant grass carp IFN could regulate the expression of Ctid-UBA. These results characterize the class I presentation, CTL response, and regulation by type I IFN in bony fish.

Chen W; Jia Z; Zhang T; Zhang N; Lin C; Gao F; Wang L; Li X; Jiang Y; Li X; Gao GF; Xia C

2010-08-01

332

Anthropometric Analysis of the Maxillary Bone and the Alar Base in Unilateral Cleft Lip With Secondary Nasal Deformity: Classification of a Piriform Margin Bony Depression.  

UK PubMed Central (United Kingdom)

Abstract Objectives: This study was conducted to measure the soft tissue of the alar base and the piriform aperture area of the maxillary bone of unilateral cleft lips with secondary nasal deformities when secondary operation are necessary to classify the alar base depression and to provide a clinical reference for the second surgery. Methods: Twenty-six patients with unilateral cleft lip with secondary nasal deformity were treated at the Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medial University. Nose data were attained preoperatively and postoperatively. Correlations were made between the soft tissue and the bony depression and patient satisfaction with the nasi basis. Classifications were then made based on these data. Results: When the distance discrepancy of the bilateral piriform aperture depression was less than 4.5 mm, we obtained a fine appearance for the nose by repairing only the soft tissues. When it was more than 5 mm, we had to combine repair of the soft tissue with a bone graft or the restitution of the alveolar cleft. When the distance was between 4.5 mm and 5 mm, the surgeon considered both the wishes of the patient and the clinic's standard procedure. Conclusions: For patients with cleft lips and palates, the bony depression was not the only factor that resulted in postoperative alar depression. Anthropometry of the nose prior to surgery was important for choosing the methods that would yield satisfactory results.

Zhang L; Lu L; Li ZJ; Liu Q; Yang ML; Wang XK; Bai XF

2012-07-01

333

Failed arthroscopic repair of a large reverse Hill-Sachs lesion using bone allograft and cannulated screws: a case report.  

UK PubMed Central (United Kingdom)

Anterior impression fractures of the humeral head (reverse Hill-Sachs lesions) are typical concomitant bony injuries of posterior shoulder dislocations. When more than 20% of the humeral articulating surface is affected, surgical treatment is required, typically necessitating open surgery. Recently, cases of successful arthroscopic treatment of small reverse Hill-Sachs lesions involving less than 30% of the articulating surface have been reported. This article presents a case of a large reverse Hill-Sachs lesion affecting over 40% of the articulating surface that was treated arthroscopically by retrograde elevation, bone allografting, and cannulated screw insertion. The postoperative radiographic images showed a successful reduction of the impacted articulating surface of the humeral head. However, at 6 months' follow-up, the patient presented with pain and symptoms of a frozen shoulder. Cross-sectional imaging showed necrosis, partial absorption, and loss of reduction of the formerly elevated segment requiring humeral head replacement. This case report shows that even though the arthroscopic retrograde elevation of large reverse Hill-Sachs lesions is technically achievable, the outcome can be unsatisfactory because of the limitations in biologic healing response associated with large lesions of the humeral articulating surface.

Moroder P; Resch H; Tauber M

2012-01-01

334

Failed arthroscopic repair of a large reverse Hill-Sachs lesion using bone allograft and cannulated screws: a case report.  

Science.gov (United States)

Anterior impression fractures of the humeral head (reverse Hill-Sachs lesions) are typical concomitant bony injuries of posterior shoulder dislocations. When more than 20% of the humeral articulating surface is affected, surgical treatment is required, typically necessitating open surgery. Recently, cases of successful arthroscopic treatment of small reverse Hill-Sachs lesions involving less than 30% of the articulating surface have been reported. This article presents a case of a large reverse Hill-Sachs lesion affecting over 40% of the articulating surface that was treated arthroscopically by retrograde elevation, bone allografting, and cannulated screw insertion. The postoperative radiographic images showed a successful reduction of the impacted articulating surface of the humeral head. However, at 6 months' follow-up, the patient presented with pain and symptoms of a frozen shoulder. Cross-sectional imaging showed necrosis, partial absorption, and loss of reduction of the formerly elevated segment requiring humeral head replacement. This case report shows that even though the arthroscopic retrograde elevation of large reverse Hill-Sachs lesions is technically achievable, the outcome can be unsatisfactory because of the limitations in biologic healing response associated with large lesions of the humeral articulating surface. PMID:22130495

Moroder, Philipp; Resch, Herbert; Tauber, Mark

2011-11-30

335

Skeletal lesions in human tuberculosis may sometimes heal: an aid to palaeopathological diagnoses.  

UK PubMed Central (United Kingdom)

In three to five percent of active cases of tuberculosis, skeletal lesions develop. Typically, these occur on the vertebrae and are destructive in nature. In this paper, we examined cases of skeletal tuberculosis from a skeletal collection (Galler Collection) with focus on the manifestation of bony changes due to tuberculosis in various body regions in association with antibiotic introduction. This skeletal collection was created in 1925-1977 by a pathologist at the University Hospital in Zürich, Ernst Galler. It includes the remains of 2426 individuals with documented clinical histories as well as autopsies. It contained 29 cases of skeletal tuberculosis lesions. We observed natural healing of vertebral lesions through several processes including fusion of vertebrae, bone deposition and fusion of posterior elements. In these cases, we observed a higher frequency and proportion of bone deposition and fusion of posterior vertebral elements where pharmacological agents were used. There were also four cases of artificial healing through surgically induced posterior spinal fusion. With the introduction of pharmaceutical treatments, the number of individuals with multiple tuberculous foci decreased from 80% to 25% when compared to individuals who did not receive any drug therapy. Investigation of comorbidities showed that pneumonia, pleuritis and being underweight were consistently present, even with pharmaceutical treatment. Our results have applications in palaeopathological diagnoses where healing and consequent bone deposition may complicate differential diagnoses.

Holloway KL; Link K; Rühli F; Henneberg M

2013-01-01

336

MRI in suspicious breast lesions  

International Nuclear Information System (INIS)

Purpose: The value of MRI in the detection and handling of oncologic pathology. Multifocality and multi centricity. Re-evaluation of post-surgical breast. Material and methods: 18 female patients (age ranged between 35-79 years, mean age 52 years) were studied with MRI under suspicion of neoplastic breast lesions. In 16 patients stereotactic automated large core-biopsies as well as surgical biopsies were performed. Results: From the 18 patients studied with MRI, 9 (50%) had palpable lesions, 5 (28%) had no palpable lesions (infra-clinical), and 4 patients (22%) post-surgical changes. 16 patients underwent surgical or core-biopsies, and 2 patients are under a follow up protocol. In 6 patients (33%) with palpable lesions MRI findings correlated well with surgical biopsies. In 2 patients with palpable nodular lesions and pathological enhancement in MRI one had a cancer and the other had a post-surgical fibrosis. In 4 patients with infra clinical lesions, MRI showed multifocal or multi centrical lesions in 3 (16%) and post-surgical changes in 1 (5%). We had 3 false positives: one patient with a palpable nodular lesion, one patient with a non palpable lesion and one case with abnormal area of gadolinium enhancement, that not represented the localization of the tumor at surgery. Conclusion: Substraction dynamic MRI has been able to detect primary occult tumors and multi centricity/multifocality, changing the surgical planning in the management of breast cancer. Post-surgical breast evaluation is always difficult, but in some cases MRI established the presence of local recurrence confirmed by the pathologist after surgical or core-biopsies. (author)

2004-01-01

337

Differential diagnosis of sacral lesions  

International Nuclear Information System (INIS)

The authors reviewed the teaching files of Temple University Hospital and Children's Hospital of Philadelphia and selected the best representative cases of various lesions of the sacrum. They selected the following lesions: metastasis, chondrosarcoma, chrodoma, plasmacytoma, giant cell tumor, osteogenic sarcoma, Ewing sarcoma, neuroblastoma, neurofibrosarcoma, hemangiopericytoma, osteoblastoma, ossifying fibroma, eosinophilic granuloma, aneurysmal bone cyst, sacrococcygeal teratoma, anterior meningocele, endodermal sinus tumor, and stress fracture. The authors illustrate, for each lesion, the likely age range, sights of predilection, likelihood of occurrence in the sacrum, and radiographic findings helpful in limiting the differential diagnosis. They demonstrate the value of bone scintigraphy in detecting, and CT in confirming, stress fractures of the sacrum.

1987-12-04

338

Shape and configuration of skin lesions: targetoid lesions.  

UK PubMed Central (United Kingdom)

What is probably the first description of targetoid or iris lesions, as they appear in erythema multiforme (EM), can be found in Thomas Bateman's 1836 textbook "Practical Synopsis of Cutaneous Diseases According to the Arrangement of Dr. Willan." EM was initially described by Bateman and later by von Hebra as an acute self-limiting skin disease, symmetrically distributed on the extremities with typical concentric "targetoid" or "iris" lesions, and often recurrent. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) were added to this syndrome later. A newer classification has created two disease spectra: EM consisting of EM minor and EM major (or bullous EM), and SJS and TEN. EM minor and EM major are often recurrent, postinfectious (especially after herpes and mycoplasma) disorders with low morbidity and almost no mortality. SJS and TEN are usually severe drug-induced reactions with high morbidity and poor prognosis. The target lesions found in each form of the disease are described and defined. Although the term "target lesion" originated from the description of EM and despite its being the dominant lesion in this disease, it is not pathognomonic for EM, and these lesions can sometimes appear in other diseases. Short descriptions of these other diseases are presented.

Wolf R; Lipozencic J

2011-09-01

339

Post-radiotherapeutic heart lesions  

International Nuclear Information System (INIS)

Heart structures have traditionally been considered radioresistant. In fact all tissues subjected to radiotherapy can develop lesions. Possible damage includes: - pericardiac fibrosis, the commonest and best individualized, associated with a constriction this leads to a stoppage pattern usually occurring late, around the 18th month. Its frequency depends directly on the total radiation dose; - fibrous myocarditis by direct damage to the heart muscle; - stenosis type lesions of the large coronary trunks; - in exceptional cases lesions of the aorta: hyperplastic degenerescence of the intima and adventitia or of the aortic sigmoid valvules and the mitral valves. Three observations are reported, concerning a coronary, a pericardiac and a coronary, myocardiac and pericardiac lesion. Following this account the irradiation techniques and main experimental data are reviewed and the prophylactic and therapeutic consequences to be derived from our observations and those of the literature are examined

1979-01-01

340

MRI atlas of MS lesions  

Energy Technology Data Exchange (ETDEWEB)

MRI has become the main paraclinical test in the diagnosis and management of multiple sclerosis. We have demonstrated more than 400 pictures of different typical and atypical MS lesions in this atlas. Each image has a teaching point. New diagnostic criteria and differential diagnosis are discussed and the book is supported by a teaching DVD where the reader can see MS lesions in different slices and sequences. (orig.)

Sahraian, Mohammad Ali [Tehran Univ. of Medical Sciences Sina Hospital (Iran). Dept. of Neurology; Radue, Ernst-Wilhelm [Univ. Hospital Basel (Switzerland). Dept. of Neuroradiology

2008-07-01

 
 
 
 
341

Use of enamel matrix protein derivative with minimally invasive surgical approach in intra-bony periodontal defects: clinical and patient-centered outcomes  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O objetivo deste estudo foi avaliar os resultados clínicos e centrados no paciente após abordagem cirúrgica minimamente invasiva (CMI) associada à aplicação das proteínas derivadas da matriz do esmalte (PDE) no tratamento de defeitos infra-ósseos. Doze pacientes apresentando um sítio com profundidade de sondagem >5 mm e sangramento à sondagem , associado à evidência radiográfica de defeito infra-ósseo, foram tratados com CMI e aplicação das PDE. Os parâme (more) tros clínicos foram avaliados imediatamente antes do procedimento e após 3 e 6 meses. A percepção de dor e desconforto do paciente durante o período trans-cirúrgico e ao longo da primeira semana de pós-operatório, bem como a satisfação estética 6 meses após o tratamento, foram avaliadas por meio de questionários. Os resultados mostraram que o uso da CMI associada à aplicação de PDE promoveu melhoras estatisticamente significantes nos parâmetros clínicos, mínima dor e desconforto e máxima satisfação estética aos pacientes. Dentro dos limites do estudo, foi demonstrado que a associação de CMI e PDE, no tratamento de defeitos infra-ósseos, é capaz de promover satisfatórios resultados clínicos e centrados no paciente. Abstract in english This case series evaluated the clinical performance and patient-centered outcomes after a minimally invasive surgical technique (MIST) associated with enamel matrix protein derivative (EMD), for the treatment of intra-bony defects. Twelve patients presenting teeth with probing depth >5 mm and bleeding on probing associated with radiographic evidence of intra-bony defect were treated by MIST associated with EMD. Clinical parameters were measured at baseline, 3 and 6 months (more) . Patient perception during the intraoperative period and during the first postoperative week was evaluated. The use of MIST with EDM promoted significant improvements in clinical parameters, minimal pain/discomfort and maximum esthetics satisfaction. Within of limits of the present study, it could be shown that MIST combined with EMD for the treatment of intra-bony defects promotes satisfactory clinical and patient-centered outcomes.

Ribeiro, Fernanda Vieira; Nociti Júnior, Francisco Humberto; Sallum, Enilson Antonio; Sallum, Antonio Wilson; Casati, Márcio Zaffalon

2010-01-01

342

Zmiany pigmentacyjnie b?ony ?luzowej jamy ustnej jako objaw chorób ogólnoustrojowych - wewn?trzustna manifestacja zespo?u Peutza-Jeghersa. Przegl?d literatury  

Directory of Open Access Journals (Sweden)

Full Text Available W jamie ustnej wyst?puje wiele zmian pigmentacyjnych, które mog? by? zarówno objawami fizjologicznymi (pigmentacja rasowa) jak równie? manifestacj? chorób systemowych (choroba Addisona) czy z?o?liwych zmian nowotworowych (melanoma). Zmiany pigmentacyjne mog? mie? ró?n? barw?, od br?zowej do czarnej w zale?no?ci od ilo?ci melaniny i g??boko?ci, na jak? jest odk?adana. Zespó? Peutza-Jeghersa (PJS) jest rzadk? chorob? genetyczn? wywo?an? mutacj? genu LKB1 (STK11) zlokalizowanego na chromosomie 19. Charakteryzuje si? wyst?powaniem pigmentacji skórno-?luzówkowych, polipowato?ci? jelit o typie hamartoma, rodzinnym wyst?powaniem i wzrastaj?cym ryzykiem pojawienia si? nowotworów w ró?nych narz?dach, takich jak: jelito cienkie, okr??nica, ?o??dek, trzustka, pier?, narz?dy rodne. Zmiany pigmentacyjne w zespole PJS s? charakterystycznie ma?e i mnogie. Okr?g?e, owalne nieregularne plamy w kolorze br?zowym lub prawie czarnym o ?rednicy od 1 mm do 1,2 cm nieregularnie rozpraszaj? si? w obr?bie b?ony ?luzowej jamy ustnej, dzi?se?, podniebienia twardego i warg (szczególnie na wardze dolnej), spotykane s? równie? powszechnie na skórze dooko?a ust, nosa, na r?kach i stopach. Plamy melanotyczne nie wymagaj? leczenia i nie wi??e si? z nimi ryzyko przeobra?enia w czerniaka. Celem niniejszego przegl?du pi?miennictwa jest zaprezentowanie charakterystyki cech klinicznych i patologicznych pigmentacji wyst?puj?cych na b?onie ?luzowej jamy ustnej ze szczególnym uwzgl?dnieniem ustnych objawów zespo?u Peutza-Jeghersa. Szczegó?owy wywiad ogólno medyczny i stomatologiczny powinien by? przeprowadzony u pacjentów, u których stwierdza si? wyst?powanie plam pigmentacyjnych w obr?bie skóry i b?ony ?luzowej jamy ustnej. W razie konieczno?ci nale?y wykona? biopsj? i badanie laboratoryjne. Z powodu wzrastaj?cego ryzyka rozwoju raka jelita, ?o??dka czy narz?dów rodnych, pacjenci z zespo?em Peutza-Jeghersa powinni by? starannie kontrolowani.

Agnieszka Sieja; Joanna Antoszewska

2009-01-01

343

Transitional carcinoma with extensive invasion of the bony orbit in a dog/ Carcinoma transicional com invasão dos ossos da órbita em um cão  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Um cão da raça Pointer Inglês, de 12 anos de idade, foi encaminhado para avaliação clínica por apresentar aumento de volume no canto temporal (medial) da órbita direita, o qual estava causando deformidade facial. O cão apresentava epífora, secreção nasal mucopurulenta, epistaxe, dispnésia e perda de peso progressiva. Uma massa foi observada na cavidade oral, próxima aos dentes pré-molares, do lado direito da face. Suspeitou-se de proliferação neoplásica b (more) aseando-se nos testes auxiliares, entre os quais: radiografia craniana e oral, ultrassonografia ocular e tomografia computadorizada. A análise histopatológica da massa revelou tratar-se de carcinoma transicional envolvendo as cavidades oral e nasal, os ossos da maxila e da órbita, além do espaço retrobulbar. Os tumores da cavidade nasal representam aproximadamente 2% de todos os tumores diagnosticados nessa espécie. O carcinoma transicional é o segundo tipo de neoplasia epitelial maligna mais comum nos seios nasais de cães. Este trabalho descreve a destruição extensiva dos tecidos moles e dos ossos da face e chama atenção para o fato de que esse tipo de neoplasia deve ser considerado nas doenças da órbita. Abstract in english A 12-year-old male English Pointer was examined due to a soft-tissue swelling at the medial canthus of the right orbital region, which was causing facial deformity. The dog had epiphora, purulent nasal discharge, epistaxis, dyspnea, and progressive weight loss. An intraoral mass was observed near the right maxillary premolars. Neoplastic disease was diagnosed based on ancillary tests, which included blood work, skull and intraoral radiographs, ocular ultrasonography and c (more) omputed tomography. Histopathology revealed transitional carcinoma involving the nasal and oral cavities, maxilla, bony orbit and retrobulbar space. Nasal tumors represent approximately 2% of all tumors diagnosed in this species. Transitional carcinoma is the second most common type of malignant epithelial tumor in the nasal sinuses. This case illustrates the extensive destruction of the soft and bony tissues of the face, including the bony orbit that this type of tumor can cause.

Paiva, S.C.C.S.; Werner, J.; Montiani-Ferreira, F.; Froes, T.R.; Machado, M.; Olbertz, L.; Lima, L.; Langohr, I.

2013-08-01

344

Comparação entre hidroxiapatita porosa de coral e enxerto ósseo autógeno em coelhos Comparison between porous hydroxyapatite of chorale and autogenous bony graft in rabbits  

Directory of Open Access Journals (Sweden)

Full Text Available A transplantação de osso autógeno continua sendo usada com sucesso, apesar das limitações que apresenta, principalmente no que se refere à morbidade aumentada, operações adicionais e aumento do custo. O objetivo desta pesquisa foi verificar a integração da hidroxiapatita porosa de coral como alternativa biológica, em forma de cerâmica, para substituir o enxerto ósseo autógeno. Foram utilizados 42 coelhos albinos (Nova Zelândia), submetidos a defeito padrão em 84 côndilos femorais, e implantação aleatória, em cada lado, de enxerto ósseo autógeno ou hidroxiapatita porosa. Foram avaliados os aspectos da evolução clínica diária dos animais. Após duas, quatro e doze semanas, grupos de 14 animais foram sacrificados e feita a avaliação radiológica e macroscópica da integração dos enxertos. Peças das regiões operadas foram colhidas para estudo histológico dessa integração. Os resultados macroscópicos mostraram que a integridade óssea, coloração, cicatrização da cortical e mobilidade dos implantes não foram estatisticamente significantes para os dois tipos de enxertos, nos diferentes tempos de observação. A diferença de uma progressiva e melhor integração dos enxertos ocorreu apenas quando se compararam os três tempos de observação, e foi considerada como conseqüência direta da evolução natural do processo cicatricial. Os parâmetros radiológicos de integração seguiram o mesmo padrão dos achados macroscópicos. Os achados microscópicos mostraram que o aparecimento de tecido ósseo maduro é retardado nos enxertos de hidroxiapatita com a ocorrência de cavidades císticas. Concluiu-se que a hidroxiapatita porosa de coral foi um substituto adequado ao enxerto ósseo autógeno em coelhos.The transplantation of autogenous bone continues being used with success, in spite of the disadvantages that it presents, mainly in what refers the increased morbidity, additional operations and increase of the cost. The objective of this research was to verify the integration of the porous hydroxyapatite of chorale as biological alternative in ceramic form to substitute the autogenous bony graft. Forty-two New Zealand rabbits were submitted to na standard condylar defect witch were randomic implanted by autogenous bony graft as porous hydroxyapatite of chorale. We made clinical, macroscopic, radiographic and histologic study among the time of evolution of two, four and twelve weeks, respectively. The results were similar between the autogenous graft and the porous hydroxyapatite of chorale in the evolution of twelve weeks. It was ended that the porous hydroxyapatite of chorale is a substitute adapted to the autogenous bony graft in rabbits.

Arthur Silveira de Figueiredo; Djalma José Fagundes; Neil Ferreira Novo; Yara Juliano; Celso Massaschi Inouye

2001-01-01

345

Multiple sclerosis masquerading as a mass lesion  

Energy Technology Data Exchange (ETDEWEB)

Six patients presenting with new neurological deficits underwent magnetic resonance imaging (MRI) that displayed mass lesions leading to diagnoses of tumor or abscess. Biopsy revealed demyelinating lesions. (orig.).

Giang, D.W. (Dept. of Neurology, Rochester Univ. Medical Center, NY (United States)); Poduri, K.R.; Friedman, P.A. (Dept. of Orthopedics, Rochester Univ. Medical Center, NY (United States)); Eskin, T.A. (Dept. of Pathology and Laboratory Medicine, Univ. of Florida Coll. of Medicine, Gainesville, FL (United States)); Ketonen, L.M. (Dept. of Radiology, Rochester Univ. Medical Center, NY (United States)); Wang, D.D. (Dept. of Neurology, Rochester Univ. Medical Center, NY (United States) Dept. of Pediatrics, Rochester Univ. Medical Center, NY (United States)); Herndon, R.M. (Dept. of Neurology, Good Samaritan Hospital, Portland, OR (United States))

1992-04-01

346

Multiple sclerosis masquerading as a mass lesion  

International Nuclear Information System (INIS)

Six patients presenting with new neurological deficits underwent magnetic resonance imaging (MRI) that displayed mass lesions leading to diagnoses of tumor or abscess. Biopsy revealed demyelinating lesions. (orig.).

1992-01-01

347

Multiple sclerosis masquerading as a mass lesion.  

UK PubMed Central (United Kingdom)

Six patients presenting with new neurological deficits underwent magnetic resonance imaging (MRI) that displayed mass lesions leading to diagnoses of tumor or abscess. Biopsy revealed demyelinating lesions.

Giang DW; Poduri KR; Eskin TA; Ketonen LM; Friedman PA; Wang DD; Herndon RM

1992-01-01

348

Ultrasonographic Assessment of Tendon Thickness, Doppler Activity and Bony Spurs of the Elbow in Patients with Lateral Epicondylitis and Healthy Subjects: A Reliability and Agreement Study.  

UK PubMed Central (United Kingdom)

Purpose: Tennis elbow, also known as lateral epicondylitis (LE), is a common disorder often assessed by ultrasound. The aim of this study was to evaluate the ultrasonographic outcomes and methods used in LE research and clinical practice.Materials and Methods: This study was designed as an intra- and interobserver reliability and agreement study. Ultrasonographic examination of the common extensor tendon of the elbow was performed. The intraobserver study examined tendon thickness twice in 20 right elbows from 20 healthy individuals at an interval of 7 to 12 days. The interobserver study examined tendon thickness, color Doppler activity, and bony spurs in 18 right elbows in 9 healthy individuals and 9 patients with LE. Two trained rheumatologists performed the interobserver examinations with the same scanner on the same day. The main outcomes were intra- and interclass correlation (ICC) and agreement.Results: In the intraobserver study, the ICC with regard to tendon thickness ranged from 0.76 to 0.81, depending on the measurement techniques used. The agreement ranged from 0.06 to 0.13 mm. In the interobserver study, the tendon thickness ICC ranged from 0.45 to 0.65 and the agreement ranged from -0.17 to 0.13 mm. The ICC for color Doppler activity was 0.93, with agreement in 14/18 (78 %) of the cases. A perfect reliability was demonstrated for bony spurs, with an ICC of 1 and exact agreement in 18/18 (100 %) of the cases.Conclusion: Good to excellent reliability was obtained for all measurements. The ultrasonographic techniques evaluated in this trial can be recommended for use in both research and clinical practice.

Krogh TP; Fredberg U; Christensen R; Stengaard-Pedersen K; Ellingsen T

2013-07-01

349

Wp?yw omeprazolu na st??enie gastryny u dzieci z zapaleniem b?ony ?luzowej ?o??dka i owrzodzeniem dwunastnicy  

Directory of Open Access Journals (Sweden)

Full Text Available Bior?c pod uwag? ma?o poznany u dzieci z zapaleniem b?ony ?luzowej ?o??dka i chorob? wrzodow? dwunastnicy z zaka?eniem H. pylori wp?yw omeprazolu na st??enie gastryny, postanowiono oznaczy? jej st??enie we krwi przed leczeniem i po eradykacji zaka?enia. Badaniami obj?to 20 dzieci w wieku od 12 do 18 lat. Rozpoznanie ustalono na podstawie badania endoskopowego oraz wyników badania histologicznego. U 12 badanych dzieci rozpoznano nad?erkowe zapalenie b?ony ?luzowej ?o??dka. U 8 dzieci zmianom zapalnym ?o??dka towarzyszy?o owrzodzenie dwunastnicy. U ka?dego dziecka bezpo?rednio po badaniu endoskopowym, a przed rozpocz?ciem leczenia, oraz 4-6 tygodni po jego zako?czeniu oznaczono gastryn? w surowicy krwi metod? radioimmunologiczn? w podwójnych próbkach przy u?yciu zestawu firmy CIS Bio International (ref GASK-PR J125). Wszystkie dzieci leczone by?y omeprazolem w dawce -0,5 mg/kg/dob? przez 7 dni w po??czeniu z antybiotykiem i nitroimidazolem. ?rednie st??enie gastryny przed leczeniem wynosi?o 104,0± 130,0 ull/ml, a po eradykacji zaka?enia H. pylori - 82,3±39,6 ull/ml. Leczenie omeprazolem wp?ywa wi?c po?rednio hamuj?co na wra?liwo?? receptora gastrynowego, przez co mo?e uzupe?niaj?co dzia?a? na hamowanie sekrecji kwasu solnego przez pomp? protonow? hamowan? stosowanym preparatem.

Iwona Igny?; Wojciech Cichy; Krzysztof Linke; Przemys?aw Majewski

2000-01-01

350

X-ray-assisted positioning of patients treated by conformal arc radiotherapy for prostate cancer: Comparison of setup accuracy using implanted markers versus bony structures  

International Nuclear Information System (INIS)

Purpose: The aim of this study was to compare setup accuracy of NovalisBody stereoscopic X-ray positioning using implanted markers in the prostate vs. bony structures in patients treated with dynamic conformal arc radiotherapy for prostate cancer. Methods and Materials: Random and systematic setup errors (RE and SE) of the isocenter with regard to the center of gravity of three fiducial markers were measured by means of orthogonal verification films in 120 treatment sessions in 12 patients. Positioning was performed using NovalisBody semiautomated marker fusion. The results were compared with a control group of 261 measurements in 15 patients who were positioned with NovalisBody automated bone fusion. In addition, interfraction and intrafraction prostate motion was registered in the patients with implanted markers. Results: Marker-based X-ray positioning resulted in a reduction of RE as well as SE in the anteroposterior, craniocaudal, and left-right directions compared with those in the control group. The interfraction prostate displacements with regard to the bony pelvis that could be avoided by marker positioning ranged between 1.6 and 2.8 mm for RE and between 1.3 and 4.3 mm for SE. Intrafraction random and systematic prostate movements ranged between 1.4 and 2.4 mm and between 0.8 and 1.3 mm, respectively. Conclusion: The problem of interfraction prostate motion can be solved by using implanted markers. In addition, the NovalisBody X-ray system performs more accurately with markers compared with bone fusion. Intrafraction organ motion has become the limiting factor for margin reduction around the clinical target volume.

2007-03-01

351

[Skin lesions in diabetic patients  

UK PubMed Central (United Kingdom)

OBJECTIVE: It is yet unknown the relationship between diabetes and determinants or triggering factors of skin lesions in diabetic patients. The purpose of the present study was to investigate the presence of unreported skin lesions in diabetic patients and their relationship with metabolic control of diabetes. METHODS: A total of 403 diabetic patients, 31% type 1 and 69% type 2, underwent dermatological examination in an outpatient clinic of a university hospital. The endocrine-metabolic evaluation was carried out by an endocrinologist followed by the dermatological evaluation by a dermatologist. The metabolic control of 136 patients was evaluated using glycated hemoglobin. RESULTS: High number of dermophytosis (82.6%) followed by different types of skin lesions such as acne and actinic degeneration (66.7%), pyoderma (5%), cutaneous tumors (3%) and necrobiosis lipoidic (1%) were found. Among the most common skin lesions in diabetic patients, confirmed by histopathology, there were seen necrobiosis lipoidic (2 cases, 0.4%), diabetic dermopathy (5 cases, 1.2%) and foot ulcerations (3 cases, 0.7%). Glycated hemoglobin was 7.2% in both type 1 and 2 patients with adequate metabolic control and 11.9% and 12.7% in type 1 and 2 diabetic patients, respectively, with inadequate metabolic controls. A higher prevalence of dermatophytoses was seen in the both groups with inadequate metabolic control. CONCLUSIONS: The results showed a high prevalence of skin lesions in diabetic patients, especially dermatophytoses. Thus, poor metabolic control of diabetes increases patient's susceptibility to skin infections.

Foss NT; Polon DP; Takada MH; Foss-Freitas MC; Foss MC

2005-08-01

352

Case report 495: Oesteochondroma-like femoral lesions due to chronic professional stress in a Swiss cheese-maker  

Energy Technology Data Exchange (ETDEWEB)

The case is presented of a 78-year-old man who was under treatment for carcinoma of the prostate with skeletal metastasis. As an incidental finding, clinically and radiologically, bony proturbances were observed to involve the right femoral shaft, reminescent of solitary cartilaginous exostoses. This was particularly true of the osseous overgrowth arising from the anterior aspect in the middle third of the right femur. A thick apposition of periosteal new bone was observed. However, a true cartilaginous cap was not present in either lesion excluding a solitary cartilagenous exostosis. A diagnosis of chronic stress was made, associated with the patient's occupation for 34 years as a cheese-maker, resulting in the bony alterations in the right femoral shaft. The history of lifting of cheeses with a weight of up to 120 kg from the shelf to the right thigh of the patient and from there to a table for washing, presumably had caused microfractures and subperiosteal hematomas on the surface of the femur. The mechanism of injury was discussed in detail and the subject of stress injuries incurred by such individuals as professional dancers was considered. The literature was reviewed.

Ballmer, P.E.; Bessler, W.T.

1988-07-01

353

Imaging of extradural spinal lesions; Bildgebung extraduraler Raumforderungen  

Energy Technology Data Exchange (ETDEWEB)

There is a wide variety of spinal extradural tumors. In addition to real neoplasms, degenerative diseases, congenital abnormalities and inflammatory disorders can be causes of extradural masses. Due to the bony boundary of the spinal canal, both benign as well as malignant masses can cause progressive neurological deficits including paraplegia. Most of the spinal tumors are benign (hemangioma of the vertebral body, degenerative diseases). In younger patients congenital abnormalities and primary tumors of the spine have to be considered, whereas in adults the list of differential diagnoses should include secondary malignancies such as metastases and lymphomas as well as metabolic disorders such as osteoporotic vertebral compression fracture and Paget's disease. Cross-sectional imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) of the spine often help to make a specific diagnosis of extradural spinal lesions and represent important tools for tumor staging and preoperative evaluation. (orig.) Das Spektrum der spinalen extraduralen Tumoren ist sehr gross. Neben echten Neoplasien koennen auch degenerative Veraenderungen und Anlagestoerungen sowie entzuendliche Veraenderungen Ursachen einer extraduralen Raumforderung sein. Aufgrund der knoechernen Begrenzung des Spinalkanals koennen neben Malignomen auch benigne Tumoren und degenerative spinale Veraenderungen zu progredienten neurologischen Ausfallsymptomen (einschliesslich Querschnittsymptomatik) fuehren. Die ueberwiegende Mehrzahl der extraduralen Raumforderungen der Wirbelsaeule ist benigne (Haemangiom des Wirbelkoerpers, degenerative Erkrankungen). Bei jungen Patienten sind Anlagestoerungen und primaere Wirbelsaeulentumoren zu beruecksichtigen, wogegen beim Erwachsenen an sekundaere Malignome, wie Metastasen und Lymphome sowie eine metabolische Erkrankung, wie die osteoporotische Wirbelkoerpersinterungsfraktur oder der Morbus Paget, differenzialdiagnostisch gedacht werden sollte. Schnittbilddiagnostische Verfahren, wie die Computertomographie und die Magnetresonanztomographie, der Wirbelsaeule ermoeglichen in vielen Faellen eine artdiagnostische Zuordnung von Wirbelsaeulenlaesionen und sind ein wichtiges Instrument fuer das Tumorstaging und die praeoperative Planung. (orig.)

Ahlhelm, F.; Schulte-Altedorneburg, G.; Naumann, N.; Reith, W. (Universitaetsklinikum des Saarlandes, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Homburg/Saar); Nabhan, A. (Universitaetsklinikum des Saarlandes, Homburg/Saar, Klinik fuer Allgemeine und Spezielle Neurochirurgie)

2006-12-15

354

Dual lesions: a diagnostic dilemma.  

UK PubMed Central (United Kingdom)

Glandular odontogenic cyst (GOC) is a rare aggressive developmental cyst of the jaw. It most commonly occurs in middle-aged people with mandible anterior region being the most affected site. This lesion can present as a unilocular or multilocular radiolucency and has high recurrence rate. The histopathologic features of the GOC are complex and often coincide with the features of dentigerous cyst, radicular cyst, and low-grade central mucoepidermoid carcinoma (CMEC). At times, the microscopic features are so similar to central low-grade mucoepidermoid carcinoma that it becomes highly impossible to distinguish the two entities even with various advanced investigations. The reported case represents one such diagnostic dilemma occurring in the maxilla which is a rare site, and the lesion/s appeared as two distinct entities, that is, GOC and CMEC on either aspects of the same side of maxilla clinically, yet showing continuity on advanced imaging and demonstrating histopathological perplexity.

Prabhat MP; Deshpande P; Gummadapu S; Babburi S; Chintamaneni RL; Sujanamulk B

2013-01-01

355

Dual lesions: a diagnostic dilemma.  

Science.gov (United States)

Glandular odontogenic cyst (GOC) is a rare aggressive developmental cyst of the jaw. It most commonly occurs in middle-aged people with mandible anterior region being the most affected site. This lesion can present as a unilocular or multilocular radiolucency and has high recurrence rate. The histopathologic features of the GOC are complex and often coincide with the features of dentigerous cyst, radicular cyst, and low-grade central mucoepidermoid carcinoma (CMEC). At times, the microscopic features are so similar to central low-grade mucoepidermoid carcinoma that it becomes highly impossible to distinguish the two entities even with various advanced investigations. The reported case represents one such diagnostic dilemma occurring in the maxilla which is a rare site, and the lesion/s appeared as two distinct entities, that is, GOC and CMEC on either aspects of the same side of maxilla clinically, yet showing continuity on advanced imaging and demonstrating histopathological perplexity. PMID:23970979

Prabhat, M P V; Deshpande, Prasannasrinivas; Gummadapu, Sarat; Babburi, Suresh; Chintamaneni, Raja Lakshmi; Sujanamulk, Bhavana

2013-07-18

356

Dual Lesions: A Diagnostic Dilemma  

Science.gov (United States)

Glandular odontogenic cyst (GOC) is a rare aggressive developmental cyst of the jaw. It most commonly occurs in middle-aged people with mandible anterior region being the most affected site. This lesion can present as a unilocular or multilocular radiolucency and has high recurrence rate. The histopathologic features of the GOC are complex and often coincide with the features of dentigerous cyst, radicular cyst, and low-grade central mucoepidermoid carcinoma (CMEC). At times, the microscopic features are so similar to central low-grade mucoepidermoid carcinoma that it becomes highly impossible to distinguish the two entities even with various advanced investigations. The reported case represents one such diagnostic dilemma occurring in the maxilla which is a rare site, and the lesion/s appeared as two distinct entities, that is, GOC and CMEC on either aspects of the same side of maxilla clinically, yet showing continuity on advanced imaging and demonstrating histopathological perplexity.

Prabhat, M. P. V.; Gummadapu, Sarat; Babburi, Suresh; Chintamaneni, Raja Lakshmi; Sujanamulk, Bhavana

2013-01-01

357

[The treatment of decubitus lesions  

UK PubMed Central (United Kingdom)

The authors present a plan for pharmacological treatment of pressure sores in patients affected by neurological pathologies: cerebrovascular accidents, head injuries, spinal cord injuries. This plan is easily applicable to all pressure sores included between first and third degree of the Reuler and Cooney classification. Authors identified some drugs specifically usefull in different cutaneous lesion degrees. Skin lesions and employed medicines are described as follows: Erythema: semi occlusive bandage with porous adsorbing membrane. This dressing must be left in for five days at least. Excoriation: bactericidal or bacteriostatic medicines if it's situated in a non pressed area while the same dressing utilized for erythema if it's localized in a pressed area. Pressure sores: if there is local infection cleanse the wound from bacterial defilement using topic antibiotics apply compresses with vitamin C if the cutaneous lesion is larger than deeper, Cadexomero lodico if it's deeper than larger. Fistulas: wadding with tablets of collagen. Necrobiosis: complete or partial surgical removal of eschar preceded by the use of enzymatic drugs when eschar is firmly adherent to subcutaneous tissues. The first group collects 9 patients with stroke and head injury: 8 with sacral and 1 with heel pressure sores. First degree pressure sores heal within 45 days and third degree lesions within 160 days. The second group collects 10 spinal cord injury patients mostly with complete lesion among which: 7 sacral, 1 heel, 1 ischiatic and 1 malleolar lesions. First degree pressure sores heal within 30 days, third degree pressure sores heal within 200 days. Healing time are considered acceptable. Pressure sores recovery swiftness can be related to different factors such as pressure sores sterness, neurological pathology and arising of clinical complication (hyperthermia, infections, low serum albumin values, etc).

Fugazza G; Moroni S; Bona F

1995-09-01

358

Renal lesions of nondomestic felids.  

UK PubMed Central (United Kingdom)

To comprehensively evaluate the occurrence of renal lesions in a variety of nondomestic felids, necropsy cases from 1978 to 2008 were reviewed from a municipal zoo and a large cat sanctuary for those in which the kidneys were examined histologically. Seventy exotic felids were identified (25 tigers, 18 lions, 6 cougars, 5 leopards, 3 snow leopards, 3 clouded leopards, 3 Canadian lynx, 2 ocelots, 2 bobcats, 2 cheetahs, 1 jaguar), and their histologic renal lesions were evaluated and compared. The most common lesion was tubulointerstitial nephritis (TIN); 36 of 70 (51%) cats were affected to some degree. Lymphocytic interstitial nephritis was the most common lesion in the tigers (9 of 25, 36%) and was rarely seen in other species. Although the renal pelvis was not available for all cats, 28 of 47 (60%) had some degree of lymphocytic pyelitis. There was no significant association between the presence of pyelitis and that of TIN. Only 1 cat had pyelonephritis. Renal papillary necrosis was present in 13 of 70 (19%) cats and was significantly associated with historical nonsteroidal anti-inflammatory drug treatment (odds ratio, 7.1; 95% confidence interval, 1.9 to 26.8). Only 1 cat (lion) had amyloid accumulation, and it was restricted to the corticomedullary junction. Primary glomerular lesions were absent in all cats. Intraepithelial pigment was identified in many of the cats but was not correlated with severity of TIN. Despite several previous reports describing primary glomerular disease or renal amyloidosis in exotic felids, these lesions were rare to absent in this population.

Newkirk KM; Newman SJ; White LA; Rohrbach BW; Ramsay EC

2011-05-01

359

MRI of orbital lesions; Pseudotumor and its simulating lesions  

Energy Technology Data Exchange (ETDEWEB)

MR imaging is helpful for evaluation of the extent of the orbital lesion. Myositic pseudotumor and lymphoid hyperplasia tend to have intermediate signal intensity on T2-weighted images, may be of value in the differential diagnosis of myositic pseudotumor. (author).

Suzuki, Yaeko; Nakasato, Tatsuhiko; Sone, Miyuki; Sasaki, Mari; Ehara, Shigeru; Tamakawa, Yoshiharu (Iwate Medical Coll., Morioka (Japan). School of Medicine); Itoh, Shiori; Konishi, Nobuhiro

1994-03-01

360

Small lesion visualization in scintimammography  

Energy Technology Data Exchange (ETDEWEB)

For scintimammography (SMM) to have wide clinical use, physicians must be able to rapidly direct biopsy of small cancers. We therefore undertook a theoretical and experimental study of lesion visibility vs. acquisition time and tumor size. Theoretical considerations as to acquisition time and contrast suggested that compression would significantly improve lesion visibility for small cancers. These predictions were confirmed with phantom studies. Patient studies showed that high confidence images of small primary breast tumors can be produced with the addition of breast compression. We conclude that breast compression would improve SMM detection of small primary breast cancers.

Weinberg, I.N. [PEM Technologies, Inc., Bethesda, MD (United States); Pani, R.; Pellegrini, R. [Univ. La Sapienza, Rome (Italy)] [and others

1996-12-31

 
 
 
 
361

Dynamic MRI of orbital lesions  

Energy Technology Data Exchange (ETDEWEB)

Study of time intensity curves was performed for 15 orbital lesions. Inflammatory lesions (2 chronic dacryoadenitis, 1 chalazion, 1 inflammatory pseudotumor), 1 meningioma, and 4 pseudolymphoma showed rapid increase with run off. They showed peak formations within 2 minutes. Tumors except for meningioma (3 malignant lymphoma, 2 retinoblastoma, 1 pleomorphic adenoma of lacrimal gland) showed gradual increase without peak formation. No difference between benign and malignancy was detected. Dynamic MRI would be useful for differential diagnosis between pseudotumor and malignant lymphoma, that has been difficult for imaging diagnosis so far. (author).

Sawada, Akihiro; Matsumoto, Hiroko (Kochi Medical School, Nangoku (Japan))

1991-04-01

362

Computed tomography of orbital lesions  

International Nuclear Information System (INIS)

Computed tomography (CT) has given a new method for examining the orbit and its contents. The indications for the application of computed tomography in ophthalmology are considered: suspected orbital tumors, unilateral exophthalmos, pareses of the ocular muscles, traumatic lesions, and malformations in the region of the orbit. The findings in 268 cases of orbital lesions examined in this study are reported and the differential diagnosis discussed. Considerable improvement and greater accuracy in diagnosis have been achieved in the field of ophthalmology by using computed tomography. Early tumor visualization is possible without risk or discomfort to the patient. (orig.) 891 MG/orig. 892 MB

1979-01-01

363

Management of prenatally diagnosed lung lesions.  

UK PubMed Central (United Kingdom)

Prenatal diagnosis provides insight into the in utero evolution of fetal thoracic lesions such as congenital cystic adenomatoid malformation (CCAM), bronchopulmonary sequestration (BPS), or hybrid lesions. Serial sonographic study of fetuses with thoracic lesions has helped define the natural history of these lesions, determine the pathophysiologic features that affect clinical outcome, and formulate in utero and postnatal management based on prognosis.

Khalek N; Johnson MP

2013-02-01

364

Adamantinoma of long bone: radiological findings. Radiologische Befunde beim Adamantinom der langen Roehrenknochen  

Energy Technology Data Exchange (ETDEWEB)

The radiological findings of adamantinomas of long bones are described in 22 patients. In 21 patients the tibia was involved and in one patient the fibula. The tumour was nearly always in the diaphysis (20 cases). The most striking radiological feature was a diaphyseal lesion confined to the bone showing multicentric translucencies. The latter showed surrounding or central ring shaped or focal areas of increased density. The lesions tended to be longitudinal, averaging 11 cm (between 3 and 25 cm). All lesions showed a sclerotic margin separating it from normal bone, at least over part of the lesion. Expanding lesions were mostly separated from the soft tissues by a bony rim (18 cases). (orig./GDG).

Bohndorf, K.; Nidecker, A.; Mathias, K.; Zidkova, H.; Kaufmann, H.; Jundt, G. (Deutsches Krebsforschungszentrum, Heidelberg (Germany). Arbeitsgemeinschaft Knochentumoren)

1992-09-01

365

Adamantinoma of long bone: radiological findings  

International Nuclear Information System (INIS)

The radiological findings of adamantinomas of long bones are described in 22 patients. In 21 patients the tibia was involved and in one patient the fibula. The tumour was nearly always in the diaphysis (20 cases). The most striking radiological feature was a diaphyseal lesion confined to the bone showing multicentric translucencies. The latter showed surrounding or central ring shaped or focal areas of increased density. The lesions tended to be longitudinal, averaging 11 cm (between 3 and 25 cm). All lesions showed a sclerotic margin separating it from normal bone, at least over part of the lesion. Expanding lesions were mostly separated from the soft tissues by a bony rim (18 cases). (orig./GDG).

1992-01-01

366

Aktywno?? kinazy tyrozynowej, p53, EGF-R oraz ekspresja Ki-67 w przewlek?ym zapaleniu b?ony ?luzowej ?o??dka na tle zaka?enia Helicobacter pylori  

Directory of Open Access Journals (Sweden)

Full Text Available Wprowadzenie: Zaka?enie Helicobacter pylori (H. pylori) jest uwa?ane za czynnik wyzwalaj?cy kaskad? procesów obejmuj?cych przewlek?e zapalenie b?ony ?luzowej ?o??dka, zanikowe zapalenia b?ony ?luzowej ?o??dka oraz metaplazj? jelitow?, które prowadz? do rozwoju raka ?o??dka. Dotychczas nie uda?o si? w pe?ni wyja?ni? roli, jak? H. pylori odgrywa w rozwoju raka ?o??dka, nie uda?o si? tak?e wyja?ni? mechanizmów tego procesu. Cel pracy: Zbadanie zwi?zków pomi?dzy nasileniem zmian zapalnych w b?onie ?luzowej ?o??dka, ekspresj? bia?ka p53, receptora nab?onkowego czynnika wzrostu (epidermal growth factor receptor- EGF-R), kinazy tyrozynowej (protein tyrosine kinase - PTK) oraz aktywno?ci? proliferacyjn? (wyra?on? jako indeks barwliwo?ci Ki-67) u pacjentów zaka?onych H. pylori. Materia? i metody: Wycinki b?ony ?luzowej ?o??dka pacjentów z objawami dyspeptycznymi pobierano do bada? w celu wykrycia zaka?enia H. pylori, oceny stopnia zapalenia b?ony ?luzowej ?o??dka (zgodnie z systemem Sydney), aktywno?ci proliferacyjnej (metod? immunohistochemiczn? z ocen? wska?nika barwliwo?ci Ki-67), aktywno?ci PTK (met. ELISA) oraz ekspresji bia?ek p53 i EGF-R (metod? immunohistochemiczn?). Wyniki: Dodatni? ekspresj? EGF-R obserwowano u 9,5% pacjentów z przewlek?ym zapaleniem b?ony ?luzowej ?o??dka. U pacjentów EGF-R dodatnich [EGF-R(+)j indeks Ki-67 oraz ca?kowita aktywno?? PTK by?y istotnie statystycznie wy?sze ni? u pacjentów EGF-R ujemnych [EGF-R(-)] (26,6±2,5 vs 19,3±5,2% oraz936,8±121,4 vs 634,3±192,5 pmol P/mg/min). Dodatni? ekspresj? bia?ka p53 obserwowano u 40% pacjentów z metaplazj? jelitow?. U pacjentów p53 dodatnich wska?nik Ki-67 by? istotnie wy?szy ni? u pacjentów p53 ujemnych (23,9±4,9vs 19,5±5,3%). Wnioski: Wyniki bada? wskazuj?, ?e przewlek?e zapalenie b?ony ?luzowej ?o??dka zzaka?eniem H. pyton u pacjentów z dodatni? ekspresj? bia?ka p53, zwi?zane jest z wi?ksz? aktywno?ci? proliferacyjn? ni? u pacjentów z brakiem ekspresji bia?ka p53. Wzrost warto?ci PTK w grupie pacjentów z EGF-R(+) mo?e wskazywa? na udzia? tego enzymu we wczesnych etapach karcynogenezy w raku ?o??dka.

Justyna Kotynia; Radzis?aw Kordek; Alicja Koz?owska; Ewa Ma?ecka-Panas

2006-01-01

367

[Review of precancerous vulvar lesions].  

UK PubMed Central (United Kingdom)

Classification of squamous vulvar precancerous lesions is based on the concept of vulvar intraepithelial neoplasia (VIN) and incorporates a three grade evaluation of the intensity of dysplastic changes (VIN I, II and III). On the basis of histological features, VIN has been subdivided into the usual VIN (u-VIN) and differentiated VIN (d-VIN), which represent the two basic pathways of the pathogenesis of vulvar squamous cell carcinoma. Although u-VIN is etiologically associated with the human papillomavirus (HPV) infection and histologically corresponds to cervical intraepithelial neoplasia, d-VIN represents the HPV-negative sequence of vulvar carcinogenesis, which is linked to lichen sclerosus (LS) and lichen simplex chronicus (LSC). u-VIN preferentially occurs in relatively young women with a history of cervical, vaginal or vulvar premalignant lesions. On the other hand, d-VIN usually affects postmenopausal women without anamnestic data of other dysplastic lesions of the lower female genital tract. d-VIN is characterized by a higher tendency of stromal invasion than u-VIN and its malignant potential is analogous to carcinoma in situ (VIN III). The histological appearance of d-VIN is subtle with basal atypia and a well-preserved differentiation of the superficial parts of the squamous epithelium, therefore it is frequently misdiagnosed for u-VIN I, LS or LSC in vulvar biopsies. Primarily because of the low diagnostic reproducibility of the u-VIN I category and the doubts about its precancerous potential as well as due to the questionable differentiation between u-VIN II and III, a revised VIN classification was proposed in 2004. The grading of vulvar precancerous lesions was abandoned, the u-VIN I category was discontinued and u-VIN II and III were merged. In the revised terminology, the term u-VIN represents HPV-associated high grade precancerous vulvar lesions (formerly u-VIN II and III) and d-VIN encompasses HPV-negative high grade dysplasias.

Skapa P; Robová H; Rob L; Záme?ník J

2012-01-01

368

[Review of precancerous vulvar lesions].  

Science.gov (United States)

Classification of squamous vulvar precancerous lesions is based on the concept of vulvar intraepithelial neoplasia (VIN) and incorporates a three grade evaluation of the intensity of dysplastic changes (VIN I, II and III). On the basis of histological features, VIN has been subdivided into the usual VIN (u-VIN) and differentiated VIN (d-VIN), which represent the two basic pathways of the pathogenesis of vulvar squamous cell carcinoma. Although u-VIN is etiologically associated with the human papillomavirus (HPV) infection and histologically corresponds to cervical intraepithelial neoplasia, d-VIN represents the HPV-negative sequence of vulvar carcinogenesis, which is linked to lichen sclerosus (LS) and lichen simplex chronicus (LSC). u-VIN preferentially occurs in relatively young women with a history of cervical, vaginal or vulvar premalignant lesions. On the other hand, d-VIN usually affects postmenopausal women without anamnestic data of other dysplastic lesions of the lower female genital tract. d-VIN is characterized by a higher tendency of stromal invasion than u-VIN and its malignant potential is analogous to carcinoma in situ (VIN III). The histological appearance of d-VIN is subtle with basal atypia and a well-preserved differentiation of the superficial parts of the squamous epithelium, therefore it is frequently misdiagnosed for u-VIN I, LS or LSC in vulvar biopsies. Primarily because of the low diagnostic reproducibility of the u-VIN I category and the doubts about its precancerous potential as well as due to the questionable differentiation between u-VIN II and III, a revised VIN classification was proposed in 2004. The grading of vulvar precancerous lesions was abandoned, the u-VIN I category was discontinued and u-VIN II and III were merged. In the revised terminology, the term u-VIN represents HPV-associated high grade precancerous vulvar lesions (formerly u-VIN II and III) and d-VIN encompasses HPV-negative high grade dysplasias. PMID:22716003

Skapa, P; Robová, H; Rob, L; Záme?ník, J

2012-01-01

369

[Galeazzi lesion in children and adults: the undiagnosed lesion].  

UK PubMed Central (United Kingdom)

Unrecognized Galeazzi fracture dislocation of the wrist (distal radius fracture with radioulnar joint disruption) may lead to a high incidence of permanent functional disability and chronic pain. A high index of suspicion, early recognition, and acute treatment of distal radioulnar joint (DRUJ) instability will avoid chronic problems. This review examines the clinical presentation, diagnostic techniques, management and prognosis in children and in adults for this type of lesion.

Maman E; Dekel S; Steinberg E

2002-07-01

370

Implant periapical lesion. Case report  

Directory of Open Access Journals (Sweden)

Full Text Available ?mplant periapical lesion (IPL) is probably not a uniform entity in all cases presented in the literature. Asseptic bone necrosis may be a cause for some of the IPLs, whilst the presence of microorganisms is not always detectable with conventional methods. A case of IPL in a male patient who underwent an extraction of 12 tooth and an immediate implantation at this site is presented. Eight months postoperatively, an IPL was revealed on radiologic examination. After surgical exploration, the IPL was removed and examined histologically and microbiologically. The implant was replaced with a longer one and a bone regeneration procedure was simultaneously carried out. From the study of the lesion and the patient’s followup, infection cannot be considered as primary cause information of presented IPL, but literature data suggests that classic histology and microbiology cannot exclude infection from IPL causatives.

Gregory Venetis, Fotis Iordanidis, Paraskevi Giovani, Lambros Zouloumis

2011-01-01

371

Desquamative lesions of the gingiva.  

UK PubMed Central (United Kingdom)

Previous reports, as well as the investigations reported here, clearly indicate that desquamative gingivitis is a clinical manifestation of several diseases. Correct identification of the underlying etiology is very important since approximately one-third of the patients with desquamative gingivitis may have cicatricial pemphigoid or pemphigus. These two diseases have broad and sometimes systemic medical implications. In cicatricial pemphigoid, not only the oral mucosa but also the conjunctiva may be involved with subsequent blindness. Because of this, patients with cicatricial pemphigoid should also be examined by an ophthalmologist and may require care of a dermatologist for systemic treatment. In pemphigus, 50% of the cases start with only oral lesions with later development of skin lesions. Because of the life-threatening nature of this disease, patients are usually placed on high systemic doses of corticosteroids. Patients with pemphigus should be referred to a dermatologist immediately.

Nisengard RJ; Neiders M

1981-09-01