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Sample records for sclerotic bone rim

  1. Quantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study.

    OpenAIRE

    Messiou, C; Collins, DJ; Morgan, VA; Robson, MD; deBono, JS; Bydder, GM; deSouza, NM

    2010-01-01

    INTRODUCTION: Ultra Short TE MRI allows signal to be detected from tissues with a very short T2.The aims of this study were to optimize a 2D UTE MRI sequence for imaging and quantification of sclerotic bone metastases, establish T2* values of sclerotic components and investigate the feasibility of using the method to assess changes in T2* of sclerotic metastases and their relation to attenuation values in patients on treatment. METHODS: Twenty-two subjects were recruited in 3 cohorts. Cohort ...

  2. Cystic angiomatosis of bone with sclerotic changes mimicking osteoblastic metastases

    International Nuclear Information System (INIS)

    Five unusual cases of cystic angiomatosis of bone which presented with the radiologic appearance of osteoblastic lesions are reported. Three patients were female (ages 37, 41, and 65 years) and two were male (ages 24 and 66 years). Although cystic angiomatosis of bone usually produces widespread osteolytic lesions with a honeycombed appearance in the skeletal system, multiple osteoblastic lesions mimicking metastatic osteoblastic carcinoma are sometimes seen. This radiological presentation has not been well emphasized in previous reports. Histologically, in addition to the angiomatous lesions, both mature thickened lamellar bone trabeculae and immature trabeculae of woven bone were found. In one of our patients, increasing density of the osteoblastic lesions was noted over time. One previous study has suggested that the age of the lesions of cystic angiomatosis is related to radiographic density. It is important to recognize this uncommon variant of cystic angiomatosis and to include this entity among the radiologic differential diagnoses when multiple osteoblastic lesions are encountered. (orig.)

  3. Sclerotic variant of lymphangiomatosis of bone: imaging findings at diagnosis and long-term follow-up

    Energy Technology Data Exchange (ETDEWEB)

    Forstner, R. [Department of Radiology, Salzburg (Austria); Datz, C. [Department of Medicine, Landeskrankenanstalten Salzburg (Austria); Dietze, O. [Department of Pathology, Landeskrankenanstalten Salzburg (Austria); Rettenbacher, L. [Department of Nuclear Medicine, Landeskrankenanstalten Salzburg (Austria)

    1998-08-01

    Lymphangiomatosis is an extremely rare congenital disorder affecting visceral organs and/or the skeletal system. In bone is is usually characterized by multiple lytic lesions with a lacelike pattern and sclerotic margins of various thickness. In this case report we demonstrate the rare sclerotic variant of lymphangiomatosis. We report the development of predominantly sclerotic lesions at different sites by serial radiographs with a long-term follow-up, and show the MRI findings of lymphangiomatosis of the spine. (orig.) With 4 figs., 12 refs.

  4. Detection of sclerotic bone metastases in the spine using watershed algorithm and graph cut

    Science.gov (United States)

    Wiese, Tatjana; Yao, Jianhua; Burns, Joseph E.; Summers, Ronald M.

    2012-03-01

    The early detection of bone metastases is important for determining the prognosis and treatment of a patient. We developed a CAD system which detects sclerotic bone metastases in the spine on CT images. After the spine is segmented from the image, a watershed algorithm detects lesion candidates. The over-segmentation problem of the watershed algorithm is addressed by the novel incorporation of a graph-cuts driven merger. 30 quantitative features for each detection are computed to train a support vector machine (SVM) classifier. The classifier was trained on 12 clinical cases and tested on 10 independent clinical cases. Ground truth lesions were manually segmented by an expert. The system prior to classification detected 87% (72/83) of the manually segmented lesions with volume greater than 300 mm3. On the independent test set, the sensitivity was 71.2% (95% confidence interval (63.1%, 77.3%)) with 8.8 false positives per case.

  5. An Inflammatory Dentigerous Cyst Shows Rim Uptake on Bone Scan: A Case Report

    International Nuclear Information System (INIS)

    Dentigerous cysts are developmental odontogenic jaw cysts, commonly manifesting in the 2nd and 3rd decades of life. This article presents an extremely rare case of dentigerous cyst showing increased uptake in the peripheral rim on bone scan. Herein, we discuss the clinical, radiographic, and histologic features of dentigerous cysts as well as the pathological mechanism underlying their activities on the bone scan. Bone scan was a sensitive tool for detecting the biologic activity of dentigerous cyst in our case

  6. The effects of hydroxyapatite coating and bone allograft on fixation of loaded experimental primary and revision implants

    DEFF Research Database (Denmark)

    Søballe, Kjeld; Mouzin, Olivier R G; Kidder, Louis A; Overgaard, Søren; Bechtold, Joan E

    2003-01-01

    We used our established experimental model of revision joint replacement to examine the roles of hydroxyapatite coating and bone graft in improving the fixation of revision implants. The revision protocol uses the Søballe micromotion device in a preliminary 8-week period of implant instability for the presence of particulate polyethylene. During this procedure, a sclerotic endosteal bone rim forms, and a dense fibrous membrane is engendered, having macrophages with ingested polyethylene and high...

  7. Bone changes in tuberous sclerosis mimicking metastases

    International Nuclear Information System (INIS)

    Sclerotic and lytic bone changes of tuberous sclerosis (TS) can mimic bone metastases. A case is reported of a patient with concomitant sclerotic bone metastases from bronchogenic carcinoma and TS bone changes, diagnosed by bone scintigraphy and magnetic resonance imaging. The increased bone uptake and abnormal magnetic resonance signal allowed distinction of TS bone lesions from bone metastases. 6 refs., 4 figs

  8. Imaging spectrum in sclerotic myelomas: an experience of three cases

    Energy Technology Data Exchange (ETDEWEB)

    Grover, S.B.; Dhar, A. [Dept. of Radiology, Safdarjang Hospital, New Delhi (India)

    2000-11-01

    The classic radiographic presentation of multiple myeloma is lytic skeletal lesions. Primary sclerotic manifestations are rare and occur only in 3 % of cases. The imaging spectrum in three cases of multiple myeloma with primary osteosclerosis is described. The first patient had spiculated sclerosis of the orbit, which is an uncommon site for myeloma. The second patient with POEMS syndrome had multiple, scattered, skeletal lesions with sclerotic margins. The third patient presented with a chest wall mass and had an expansile thick spiculated sclerosis in the rib. The wide imaging spectrum possible in sclerotic myelomas and their relevant differential diagnosis is emphasized. (orig.)

  9. Micromorphological and hardness analyses of human and bovine sclerotic dentin: a comparative study

    Scientific Electronic Library Online (English)

    Gisela Muassab, Castanho; Márcia Martins, Marques; Juliana Barbosa, Marques; Maitê André, Camargo; Antonio Alberto De, Cara.

    2011-06-01

    Full Text Available The purpose of this study was to test the hypothesis that both human and bovine sclerotic dentin have similar hardness properties, in addition to similar micromorphological characteristics. Sixteen teeth (8 human and 8 bovine) exhibiting exposed dentin in the incisal edge and showing characteristics [...] typical of sclerosis were used. Vickers surface microhardness testing was conducted. Three areas of the dentin surface of each specimen were selected. All teeth were processed for scanning electron microscopy in order to estimate the amount (in percentage) of solid dentin on the sclerotic dentin surface. The data were compared by Student's t test (? = 0.05). The micromorphological and microhardness data were compared by Pearson's linear correlation test (? = 0.05). The mean percentages of solid dentin of human and bovine sclerotic dentin were similar (human 90.71 ± 0.83 and bovine 89.08 ± 0.81, p = 0.18). The mean microhardness value (VHN) of human sclerotic dentin was significantly higher than that of bovine sclerotic dentin (human 45.26 ± 2.92 and bovine 29.93 ± 3.83, p = 0.006). No correlation was found between the microhardness values and the amount of solid dentin in the sclerotic dentin, irrespective of the species considered (human R² = 0.0240, p = 0.714; bovine R² = 0.0017, p = 0.923; and combined R² = 0.038, p = 0.46). We concluded that although both bovine and human sclerotic dentin present a similar amount of solid tissue, human sclerotic dentin presents higher microhardness than bovine sclerotic dentin.

  10. Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases.

    Science.gov (United States)

    Lee, Seung Yun; Cardones, Adela R; Doherty, Joshua; Nightingale, Kathryn; Palmeri, Mark

    2015-11-01

    In this study, acoustic radiation force impulse (ARFI) and shear wave elasticity imaging (SWEI) were applied to the skin to investigate the feasibility of their use in assessing sclerotic skin diseases. Our motivation was to develop a non-invasive imaging technology with real-time feedback of sclerotic skin disease diagnosis. This paper shows representative results from an ongoing study, recruiting patients with and without sclerosis. The stiffness of the imaged site was evaluated using two metrics: mean ARFI displacement magnitude and bulk shear wave speed inside the region of interest (ROI). In a subject with localized graft versus host disease (GVHD), the mean ARFI displacement inside sclerotic skin was 61% lower (p ARFI and SWEI can successfully differentiate sclerotic lesions from normal dermis. PMID:26259888

  11. Comparison of Sporadic Sclerotic Fibroma and Solitary Fibrous Tumor in the Oral Cavity

    OpenAIRE

    Lee, Ju-Han; An, Jung-Suk; Lee, Eung Seok; Kwon, Soon-Young; Kim, Young-Sik

    2007-01-01

    Sporadic sclerotic fibroma (SF) and solitary fibrous tumor (SFT) arising in the oral cavity are very rare. In this report, we describe two cases of oral pathology, one involving SF and the other involving SFT. Both cases presented with well-circumscribed, firm nodules with similar gross findings. However, the histologic findings of the SF and SFT showed rather distinct features. The SF was composed of hyalinized sclerotic collagen bundles arranged in a whorled pattern, whereas the SFT was for...

  12. CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS

    Directory of Open Access Journals (Sweden)

    Taeko Nakamura-Wakatsuki

    2013-10-01

    Full Text Available Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fingers have not been reported to date. Mucin deposition in the sclerotic skin may be a predisposing factor in the induction of myxoid cyst on the scleroderma finger in our patient.

  13. Clinical observation of Ahmed glaucoma valve implantation for refractory glaucoma by directly puncturing the sclerotic tunnel

    Directory of Open Access Journals (Sweden)

    Zhi-Ke Xu

    2015-02-01

    Full Text Available AIM: To observe the clinic effects and complication of Ahmed glaucoma valve(AGVimplantation in refractory glaucoma by using the 23G syringe needle direct puncture the sclerotic tunnel.METHODS: Forty-four cases(44 eyesof refractory glaucoma underwent AGV implantation by useing the 23G syringe needle direct puncture the sclerotic tunnel. The intraocular pressure(IOP, visual acuity, and complication of post-operation were contrasted with those of pre-operation. RESULTS:The success rate was 84.1%, the mean preoperative IOP in research group was 52.1±10.1mmHg, and the last follow up mean IOP was 15.6±6.9mmHg. Compared with the preoperative visual acuity, 11 eyes increased, 27 eyes had no changes and 6 eyes decreased. The main post-operative complications included shallow anterior chamber(4 eyes, choroidal detachment(3 eyes, drainage tube shift(1 eye, hyphema(6 eyes, drainage tube blockage(1 eye, expulsive choroidal hemorrhage(1 eye, and fiber wrap of drainage tray(5 eyes.CONCLUSION: AGV implantation by direct puncture the sclerotic tunnel is feasible and easy. It avoids of making sclerotic petal and the xenogenic sclera transplanting, simplified the operation technique, prevent the leakage of around tube. The shallow anterior chamber rate is lower. It is an effective procedure for refractory glaucoma.

  14. Transplante renal sem imunossupressão de manutenção. Pares monozigóticos e receptores de rim e medula óssea do mesmo doador / Renal transplantation without maintenance immunosuppression. Identical twins and kidney transplantation following a successful bone marrow graft

    Scientific Electronic Library Online (English)

    Riad Abdel, Hadi; Gustavo Gomes, Thomé; Adriana Reginato, Ribeiro; Roberto Ceratti, Manfro.

    2015-06-01

    Full Text Available Resumo Pacientes que receberam transplantes renais sem imunossupressão de manutenção têm sido esporadicamente relatados. Os casos incluem relatos de pacientes não aderentes que suspenderam a medicação imunossupressora, transplantes entre gêmeos monozigóticos, transplante renal após um bem sucedido t [...] ransplante de medula óssea do mesmo doador e transplante simultâneo de medula óssea e rim para tratamento de pacientes com mieloma múltiplo com insuficiência renal associada. Existem, atualmente, ensaios clínicos em andamento com o propósito de induzir tolerância imunológica específica ao doador utilizando a infusão de células hematopoiéticas do mesmo doador do enxerto renal. A seguir, descrevemos dois casos de transplante renal sem imunossupressão como exemplos de situações descritas acima. Abstract in english Abstract Renal transplantation without maintenance immunosuppression has been sporadically reported in the literature. The cases include non-adherent patients who discontinued their immunosuppressive medications, transplantation between identical twins, kidney transplantation after a successful bone [...] marrow graft from the same donor and simultaneous bone marrow and kidney transplantation for the treatment of multiple myeloma with associated renal failure. There are also ongoing clinical trials designed to induce donor specific transplant tolerance with infusion of hematopoietic cells from the same kidney donor. Here we describe two cases of renal transplantation without immunosuppression as examples of situations described above.

  15. Alar Rim Deformities.

    Science.gov (United States)

    Totonchi, Ali; Guyuron, Bahman

    2016-01-01

    The alar rim plays an important role in nasal harmony. Alar rim flaws are common following the initial rhinoplasty. Classification of the deformities helps with diagnosis and successful surgical correction. Diagnosis of the deformity requires careful observation of the computerized or life-sized photographs. Techniques for treatment of these deformities can easily be learned with attention to detail. PMID:26616701

  16. CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS

    OpenAIRE

    Taeko Nakamura-Wakatsuki; Toshiyuki Yamamoto

    2013-01-01

    Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fin...

  17. Rim Sign in Acute Cholecystitis

    International Nuclear Information System (INIS)

    The 'rim sign' is a rim of increased hepatic activity adjacent to the gall bladder fossa and known as an useful indicator of acute cholecystitis. Also, many reports suggested that if rim sign is positive there is an increased risk for complications such as perforation and gangrene. To evaluate the usefulness of this rim sign, we reviewed 32 cases that were pathologically confirmed. The incidence of rim sign was 47% similar to other reports but with our results, the rim sign was not specific to acute cholecystitis nor indicator of increased risk for complications.

  18. Bone

    Science.gov (United States)

    Helmberger, Thomas K.; Hoffmann, Ralf-Thorsten

    The typical clinical signs in bone tumours are pain, destruction and destabilization, immobilization, neurologic deficits, and finally functional impairment. Primary malignant bone tumours are a rare entity, accounting for about 0.2% of all malignancies. Also benign primary bone tumours are in total rare and mostly asymptomatic. The most common symptomatic benign bone tumour is osteoid osteoma with an incidence of 1:2000.

  19. Linhas escleróticas metafisárias em crianças e adolescentes em uso de alendronato / Sclerotic metaphyseal lines in children and adolescents treated with alendronate

    Scientific Electronic Library Online (English)

    Érika C.C., Silva; Maria Teresa R.A., Terreri; Tania C.M. de, Castro; Cássia P.L., Barbosa; Artur R.C., Fernandes; Maria Odete E., Hilário.

    2010-06-01

    Full Text Available INTRODUÇÃO: Os bisfosfonatos inibem a reabsorção óssea pela interferência na ação dos osteoclastos. Dentre os efeitos adversos, as linhas escleróticas em metáfise de ossos longos são descritas como principal alteração radiográfica na faixa etária pediátrica. OBJETIVO: Avaliar a frequência de alteraç [...] ões radiográficas causadas pelo alendronato utilizado em crianças e adolescentes com baixa densidade óssea ou calcinose. PACIENTES E MÉTODOS: Foi realizado um estudo do tipo coorte retrospectiva analisando-se prontuários de 21 pacientes que fizeram uso de alendronato semanal por no mínimo 10 meses. Os pacientes realizaram radiografias de ossos longos antes do início do alendronato e aproximadamente um ano após o seu uso. RESULTADOS: Onze pacientes (52,3%) apresentaram linhas escleróticas em metáfise dos ossos longos. A localização mais frequente foi em tíbia (8/11 pacientes), seguida de fêmur (7/11), úmero (6/11), rádio (4/11), ulna (3/11) e fíbula (2/11). Nenhum paciente apresentou regressão das alterações radiográficas durante o tempo de evolução (até 1,1 ano após a suspensão do alendronato). CONCLUSÃO: Se usado com critério, o alendronato é seguro e as alterações radiográficas não mostraram ter um significado mais importante. Abstract in english INTRODUCTION: Bisphosphonates inhibit bone resorption by interfering with the action of osteoclasts. Among the adverse effects, sclerotic lines observed in the metaphysis of long bones have been described as the main imaging finding in pediatric patients. OBJECTIVE: To evaluate the frequency of radi [...] ographic changes caused by alendronate in children and adolescents with low bone density or calcinosis. PATIENTS AND METHODS: We conducted a cross-sectional study with 21 patients who were treated with once-weekly alendronate for at least 10 months. Patients underwent x-rays of long bones before the start of alendronate and approximately one year after its use. RESULTS: Eleven patients (52.3%) had sclerotic lines in the metaphysis of long bones. The most frequent site was the tibia (8/11 patients), followed by the femur (7/11), humerus (6/11), radius (4/11), ulna (3/11), and fibula (2/11). Regression of radiographic changes during the study period (up to 1.1 years after discontinuation of alendronate) was not observed. CONCLUSION: If used carefully, alendronate is safe and radiographic changes have not been shown to be clinically relevant.

  20. RIMS: Resource Information Management System

    Science.gov (United States)

    Symes, J.

    1983-01-01

    An overview is given of the capabilities and functions of the resource management system (RIMS). It is a simple interactive DMS tool which allows users to build, modify, and maintain data management applications. The RIMS minimizes programmer support required to develop/maintain small data base applications. The RIMS also assists in bringing the United Information Services (UIS) budget system work inhouse. Information is also given on the relationship between the RIMS and the user community.

  1. Ossicular bone modeling in acute otitis media

    DEFF Research Database (Denmark)

    Salomonsen, Rasmus Lysholdt; Hermansson, Ann; Cayé-Thomasen, Per

    2010-01-01

    A number of middle ear diseases are associated with pathologic bone modeling, either formative or resorptive. As such, the pathogenesis of a sclerotic mastoid has been controversial for decades. Experimental studies on acute middle ear infection have shown progressive osteoneogenesis in the bone structures surrounding the middle ear cavity, and a few studies have reported acute changes of the ossicular chain. However, detailed qualitative and quantitative information on ossicular bone modeling d...

  2. Arthroscopic Acetabular Rim Resection in the Treatment of Femoroacetabular Impingement

    OpenAIRE

    Chow, Roxanne M.; Krych, Aaron J.; Levy, Bruce A.

    2013-01-01

    Appropriate identification and precise resection of the pincer lesion are integral parts of the arthroscopic surgical treatment of femoroacetabular impingement. Preoperative radiographic planning of the bone resection, as well as executing the plan intraoperatively using both fluoroscopic and arthroscopic cues, is critical to adequately removing the pincer lesion. We present our surgical technique of removing the impinging bone by defining the focal acetabular rim overcoverage, accessing the ...

  3. Histologia e ultraestrutura do rim e rim cefálico do pacu

    Directory of Open Access Journals (Sweden)

    Gerlane M. Costa

    2012-05-01

    Full Text Available O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de cada órgão com o uso de microscopia de luz e microscopia eletrônica de transmissão. O resultado da análise macroscópica mostrou que a localização do rim e rim cefálico são as mesmas encontradas na maioria dos teleósteos. O rim apresentou uma forma em "H", onde a região média se expandia sobre a bexiga natatória. O rim cefálico se apresentou como uma dilatação na região cranial do rim, mostrando-se bem visível. Na microscopia eletrônica de transmissão também foram observadas similaridades ultraestruturais com outros teleósteos. Observando nossos resultados concluímos que histologicamente e ultraestruturalmente, os órgãos linfóides rim e rim cefálico de Piaractus mesopotamicus são similares aos de outros teleósteos.

  4. Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice

    Scientific Electronic Library Online (English)

    Yinghua, Song; Lubing, Zhu; Ming, Li.

    2013-10-01

    Full Text Available OBJECTIVE: To investigate the antifibrotic effects of crocetin in scleroderma fibroblasts and in sclerotic mice. METHODS: Skin fibroblasts that were isolated from three systemic scleroderma (SSc) patients and three healthy subjects were treated with crocetin (0.1, 1 or 10 ?M). Cell proliferation [...] was measured with an MTT assay. Alpha-smooth muscle actin was detected via an immunohistochemical method. Alpha 1 (I) procollagen (COL1A1), alpha 1 (III) procollagen (COL3A1), matrix metalloproteinase (MMP)-1 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 mRNA levels were measured using real-time PCR. SSc mice were established by the subcutaneous injection of bleomycin. Crocetin (50 mg/kg/d) was injected intraperitoneally for 14 days. Dermal thickness and lung fibrosis were assessed with Masson's trichrome staining. Plasma ET-1 was detected with an enzyme-linked immunosorbent assay (ELISA). Skin and lung ET-1 and COL1A1 mRNA levels were measured via real-time PCR. RESULTS: Crocetin inhibited the proliferation of SSc and normal fibroblasts, an effect that increased with crocetin concentration and incubation time. Crocetin decreased the expression of ?-SMA and the levels of mRNA for COL1A1, COL3A1 and matrix metalloproteinase-1, while crocetin increased TIMP-1 mRNA levels in both SSc and normal fibroblasts. Skin and lung fibrosis was induced, and the levels of ET-1 in the plasma, skin and lungs were elevated in bleomycin-injected mice. Crocetin alleviated the thickening of the dermis and lung fibrosis; decreased COL1A1 mRNA levels in the skin and lung; and simultaneously decreased ET-1 concentrations in the plasma and ET-1 mRNA levels in the skin and lungs of the bleomycin-induced sclerotic mice, especially during the early phase (weeks 1-3). CONCLUSION: Crocetin inhibits cell proliferation, differentiation and collagen production in SSc fibroblasts. Crocetin alleviates skin and lung fibrosis in a bleomycin-induced SSc mouse model, in part due to a reduction in ET-1.

  5. The detection of sclerotic changes of the coronaries and heart valves by scanning beams (ultrafast computed tomography using EVOLUTION)

    International Nuclear Information System (INIS)

    With the advent of ultrafast computed tomography the range of diagnostic procedures for the quantitative determination of pathological changes in the coronary arteries has been broadened. The calcified coronary plaques found in this study, which in some of the patients were markedly pronounced, gave no immediate clue as to what extent sclerotic changes had already occurred in the coronaries examined. Nor was it possible on the basis of this method to pinpoint the vascular sections showing calcified plaques in patients undergoing maintenance dialysis. It may, however, permit careful predictions to be made for patients at a high risk of developing coronary artery disease. Sclerotic changes of the heart values occur with above-average frequency in dialysis patients and may be assessed quantitatively by the method described. The results described show that findings revealed by scanning electron beams may provide indirect information on metabolic processes in patients suffering from chronic ailments. (orig./MG)

  6. The effects of hydroxyapatite coating and bone allograft on fixation of loaded experimental primary and revision implants

    DEFF Research Database (Denmark)

    SØballe, Kjeld; Mouzin, Olivier R G

    2003-01-01

    We used our established experimental model of revision joint replacement to examine the roles of hydroxyapatite coating and bone graft in improving the fixation of revision implants. The revision protocol uses the Søballe micromotion device in a preliminary 8-week period of implant instability for the presence of particulate polyethylene. During this procedure, a sclerotic endosteal bone rim forms, and a dense fibrous membrane is engendered, having macrophages with ingested polyethylene and high levels of inflammatory cytokines. At the time of revision after 8 weeks, the cavity is revised with either a titanium alloy (Ti) or a hydroxyapatite (HA) 6.0 mm plasma-sprayed implant, in the presence or absence of allograft packed into the initial 0.75 mm peri-implant gap. The contralateral limb is subjected to primary surgery with the same implant configuration, and serves as control. 8 implants were included in each of the 8 treatment groups (total 64 implants in 32 dogs). The observation period was 4 weeks after revision. Outcome measures are based on histomorphometry and mechanical pushout properties. The revision setting was always inferior to its primary counterpart. Bone graft improved the revision fixation in all treatment groups, as also did the HA coating. The sole exception was revision-grafted HA implants, which reached the same fixation as primary Ti and HA grafted implants. The revision, which was less active in general, seems to need the dual stimulation of bone graft and HA implant surface, to obtain the same level of fixation associated with primary implants. Our findings suggest that the combination of HA implant and bone graft may be of benefit in the clinical revision implant setting.

  7. Femoroacetabular impingement with chronic acetabular rim fracture - 3D computed tomography, 3D magnetic resonance imaging and arthroscopic correlation.

    Science.gov (United States)

    Chhabra, Avneesh; Nordeck, Shaun; Wadhwa, Vibhor; Madhavapeddi, Sai; Robertson, William J

    2015-07-18

    Femoroacetabular impingement is uncommonly associated with a large rim fragment of bone along the superolateral acetabulum. We report an unusual case of femoroacetabular impingement (FAI) with chronic acetabular rim fracture. Radiographic, 3D computed tomography, 3D magnetic resonance imaging and arthroscopy correlation is presented with discussion of relative advantages and disadvantages of various modalities in the context of FAI. PMID:26191497

  8. Three-dimensional trabecular bone architecture of the lumbar spine in bone metastasis from prostate cancer: comparison with degenerative sclerosis

    International Nuclear Information System (INIS)

    Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. The objective of this study was to clarify the three-dimensional (3D) trabecular bone microstructure in bone metastasis from prostate cancer by comparison with normal and degenerative sclerotic bone lesions, using microcomputed tomography (micro-CT). A total of 32 cancellous bone samples were excised from the lumbar spine of six autopsy patients: 15 metastatic samples (one patient), eight degenerative sclerotic samples (four patients) and the rest from normal sites (three patients). The samples were serially scanned cross-sectionally by micro-CT with a pixel size of 23.20 ?m, slice thickness of 18.56 ?m, and image matrix of 512 x 512. Each image data set consisted of 250 consecutive slices. The volumes of interest (96 x 96 x 120 voxels) were defined in the original image sets and 3D indices of the trabecular microstructure were determined. The trabecular thickness (Tb.Th) in degenerative sclerotic lesions was significantly higher than that in normal sites, whereas no significant difference was observed in trabecular number (Tb.N). By contrast, in metastatic lesions, the Tb.N was significantly higher with increased bone volume fraction (BV/TV) than in normal sites, and no significant difference was found in Tb.Th. The characteristics of the trabecular surface in the metastatic samples showed concave structural elements with an increase in BV/TV, indicating osteolysis of the trabecular bone. In 3D reconstructed images, increased trabecular bone with an irregular surface was observed in samples from metastatic sites, which were uniformly sclerotic on soft X-ray radiographs. These results support, through 3D morphological features, the strong bone resorption effect in bone metastasis from prostate cancer. (orig.)

  9. Portable basketball rim testing device

    Science.gov (United States)

    Abbott, W. Bruce (610 Clover St., Cheney, WA 99004); Davis, Karl C. (Box 722, Richland, WA 99352)

    1993-01-01

    A portable basketball rim rebound testing device 10 is illustrated in two preferred embodiments for testing the rebound or energy absorption characteristics of a basketball rim 12 and its accompanying support to determine likely rebound or energy absorption charcteristics of the system. The apparatus 10 includes a depending frame 28 having a C-clamp 36 for releasably rigidly connecting the frame to the basketball rim 12. A glide weight 60 is mounted on a guide rod 52 permitting the weight 60 to be dropped against a calibrated spring 56 held on an abutment surface on the rod to generate for deflecting the basketball rim and then rebounding the weight upwardly. A photosensor 66 is mounted on the depending frame 28 to sense passage of reflective surfaces 75 on the weight to thereby obtain sufficient data to enable a processing means 26 to calculate the rebound velocity and relate it to an energy absorption percentage rate of the rim system 12. A readout is provided to display the energy absorption percentage.

  10. Ossicular bone modeling in acute otitis media

    DEFF Research Database (Denmark)

    Salomonsen, Rasmus Lysholdt; Hermansson, Ann

    2010-01-01

    A number of middle ear diseases are associated with pathologic bone modeling, either formative or resorptive. As such, the pathogenesis of a sclerotic mastoid has been controversial for decades. Experimental studies on acute middle ear infection have shown progressive osteoneogenesis in the bone structures surrounding the middle ear cavity, and a few studies have reported acute changes of the ossicular chain. However, detailed qualitative and quantitative information on ossicular bone modeling dynamics has not been accounted for and is thus the purpose of this study.

  11. Window prototype investigations : Rim seal construction

    DEFF Research Database (Denmark)

    Schultz, JØrgen Munthe

    1996-01-01

    This chapter describes the requirements to be set for a proper rim seal construction for aerogel glazings and includes theoretically parameter analyses of thermal bridge effect, water vapour diffusion and gas diffusion through the rim seal. Different ideas for rim seal solutions are described.

  12. Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis

    Directory of Open Access Journals (Sweden)

    V Silva

    2007-01-01

    Full Text Available Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Quinck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones.A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, diagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

  13. Adjuvant therapies of bone graft around non-cemented experimental orthopedic implants stereological methods and experiments in dogs

    DEFF Research Database (Denmark)

    Baas, Jørgen

    2008-01-01

    Revision arthroplasty is a challenging aspect of the otherwise quite successful area of joint replacement surgery. The instable interaction between implant and host bone has often initiated a destructive process of inflammation and osteolysis, rendering the revision site sclerotic and with insufficient bone stock. One way of dealing with this is to build up a bed of tightly packed morselized bone graft to support the revision implant in a procedure often referred to as impaction grafting. Fresh ...

  14. Facing rim cavities fluctuation modes

    Science.gov (United States)

    Casalino, Damiano; Ribeiro, André F. P.; Fares, Ehab

    2014-06-01

    Cavity modes taking place in the rims of two opposite wheels are investigated through Lattice-Boltzmann CFD simulations. Based on previous observations carried out by the authors during the BANC-II/LAGOON landing gear aeroacoustic study, a resonance mode can take place in the volume between the wheels of a two-wheel landing gear, involving a coupling between shear-layer vortical fluctuations and acoustic modes resulting from the combination of round cavity modes and wheel-to-wheel transversal acoustic modes. As a result, side force fluctuations and tonal noise side radiation take place. A parametric study of the cavity mode properties is carried out in the present work by varying the distance between the wheels. Moreover, the effects due to the presence of the axle are investigated by removing the axle from the two-wheel assembly. The azimuthal properties of the modes are scrutinized by filtering the unsteady flow in narrow bands around the tonal frequencies and investigating the azimuthal structure of the filtered fluctuation modes. Estimation of the tone frequencies with an ad hoc proposed analytical formula confirms the observed modal properties of the filtered unsteady flow solutions. The present study constitutes a primary step in the description of facing rim cavity modes as a possible source of landing gear tonal noise.

  15. Osteoid osteoma of a metacarpal bone: A case report and review of the literature

    OpenAIRE

    Chronopoulos Efstathios; Xypnitos Fragiskos N; Nikolaou Vassilios S; Efstathopoulos Nicolas; Korres Dimitrios

    2008-01-01

    Abstract Introduction Osteoid osteoma is a benign tumor of the growing skeleton. It presents with pain, which is usually worse at night. The radiographic features consist of a central oval or round nidus surrounded first by a radiolucent area followed by another area of sclerotic bone. In the hand, osteoid osteoma is more commonly located in the phalanges and carpal bones. The metacarpals are the least common sites for osteoid osteoma. Case presentation We present a case of an osteoid osteoma...

  16. An Atypical Case of POEMS Syndrome with an Osteolytic Bone Lesion.

    Science.gov (United States)

    Rahul, Kumar; Handa, Nayha; Chandrashekhara, S H; Usha, Thingujam; Singh, Anuradha

    2015-06-01

    POEMS syndrome is a rare multisystem disorder with an underlying plasma cell dyscrasia associated with Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes. Usually it is associated with sclerotic bone lesions. It usually manifests in 5(th)-6(th) decade of life with a mean survival period of eight years. We report an unusual case of a 28-year-old male diagnosed with POEMS syndrome and had a lytic bone lesion the in sternum. PMID:26266203

  17. Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea / Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis

    Scientific Electronic Library Online (English)

    V, Silva; H, Madrid; S, Anticevic.

    Full Text Available Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Qui [...] nck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones. Abstract in english A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, d [...] iagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

  18. Dietary determinants of post-menopausal bone loss at the lumbar spine: a possible beneficial effect of iron.

    OpenAIRE

    Abraham, R.; Walton, J.; Russell, L; Wolman, R; Wardley-Smith, B; Green, JR; Mitchell, A.; Reeve, J

    2006-01-01

    INTRODUCTION: Previous studies suggesting different effects of diet on post-menopausal bone loss may have given conflicting results because they sometimes failed to exclude confounding conditions or used imprecise methodology. DESIGN: To identify dietary determinants of bone loss from the lumbar spine after menopause in women not taking hormone replacement who developed no evidence of spondylotic or sclerotic degenerative disease, forty-three women were followed with repeated (mean = 12) meas...

  19. Bone tumors with an associated pathologic fracture: Differentiation between benign and malignant status using radiologic findings

    International Nuclear Information System (INIS)

    To determine whether benign and malignant bone tumors with associated pathologic fractures can be differentiated using radiologic findings. Seventy-eight patients (47 men and 31 women, age range: 1-93 years) with a bone tumor and an associated pathologic fracture from 2004 to 2013 constituted the retrospective study cohort. The tumor size, margin, and enhancement patterns; the presence of sclerotic margin, the peritumoral bone marrow, soft tissue edema, extra-osseous soft tissue mass, intratumoral cystic/hemorrhagic/necrotic regions, mineralization/sclerotic regions, periosteal reaction and its appearance; and cortical change and its appearance were evaluated on all images. Differences between the imaging characteristics of malignant and benign pathologic fractures were compared using Pearson's chi-square test and the 2-sample t-test. There were 22 benign and 56 malignant bone tumors. Some factors were found to significantly differentiate between benign and malignant tumors; specifically, ill-defined tumor margin, the presence of sclerotic tumor margin and an extra-osseous soft tissue mass, the absence of cystic/necrotic/hemorrhagic portions in a mass, the homogeneous enhancement pattern, and the presence of a displaced fracture and of underlying cortical change were suggestive of malignant pathologic fractures. Some imaging findings were helpful for differentiating between benign and malignant pathologic fractures

  20. Unusual Bilateral Rim Fracture in Femoroacetabular Impingement

    Science.gov (United States)

    Rafols, Claudio; Monckeberg, Juan Edo; Numair, Jorge

    2015-01-01

    This is a report of one case of bilateral acetabular rim fracture in association with femoroacetabular impingement (FAI), which was treated with a hip arthroscopic procedure, performing a partial resection, a labral reinsertion, and a subsequential internal fixation with cannulated screws. Up to date, there are in the literature only two reports of rim fracture and “os acetabuli” in association with FAI. In the case we present, the pincer and cam resection were performed without complications; the technique used was published previously. With this technique the head of the screw lays hidden by the reattached labrum. We removed partially the fractured rim fragment and the internal fixation of the remaining portion was achieved with a screw. In the event of a complete resection of the fragment, it would have ended with a LCE angle of 18° and a high probability of hip instability. We believe that this bilateral case helps establish the efficacy and reproducibility of the technique described by Larson. PMID:25722907

  1. Echogenic rim of hepatic hemangioma on abdominal ultrasound

    International Nuclear Information System (INIS)

    To investigate the association between the size of the hepatic hemangioma and the shape and thickness of the echogenic rim of hepatic hemangioma on abdominal ultrasound. We examined 47 cases (M:F=24:23, mean age 47.1) of hepatic hemangiomas with echogenic rim on abdominal ultrasound during the past 2 years. Radiologic findings were retrospectively reviewed in terms of completeness and thickness of echogenic rim. If echogenic rim showed even thickness, it was measured. But if not, the maximum and minimum thickness of the rim was measured. The association between the size of hemangioma and the completeness and thickness of the echogenic rim were analyzed statistically. Of the 47 cases, complete echogenic rim and incomplete echogenic rim were obtained in 29 (62%) and 18 (38%) cases, respectively. Twenty-two cases of hemangioma were less than 2 cm in diameter, and their distribution according to echogenic rim were as follows: complete echogenic rim (17/20, 91% mean thickness 2.2 cm) and uneven thickness with complete echogenic rim (3/20, 15%, range:2.0-6.1 mm). Twenty-five hemangiomas were larger than 2 cm in diameter and their distribution according to echogenic rim were as follows: complete echogenic rim (n=9, 34%), incomplete echogenic rim (n=16, 64%0,even thickness with complete echogenic rim (3/9, 33%, mean thickness 2.2 mm) and uneven thickness with complete echogenic rim (6/9,67%, range: 2.0-7.6 mm). In statistical analysis, hemangiomas more than 2 cm in diameter were more likely to have incomplete echogenic rim (p<0.05) than those of less than 2 cm; hemangiomas more than with more than 2 cm in diameter and complete echogenic rim showed uneven thickness of echogenic rim (p<0.05), more often than those of less than 2 cm diameter. Hemangiomas with more than 2 cm in diameter showed more frequent incomplete echogenic rim than those of less than 2 cm in diameter, which had more frequent complete echogenic rim. Hemangiomas with complete echogenic rim and even rim thickness were more prevalent in those with less than 2 cm in diameter. Uneven rim thickness was present more often in those with more than 2 cm in diameter.

  2. Carcinoma medular do rim Renal medullary carcinoma

    Directory of Open Access Journals (Sweden)

    Paulo Guilherme de Oliveira Salles

    2006-04-01

    Full Text Available É relatado caso de paciente de 24 anos, portador de traço falciforme, com imagem sólida no rim direito, submetido a nefrectomia radical que revelou tumor, cujo exame anatomopatológico permitiu o diagnóstico de carcinoma medular do rim. Os autores discutem aspectos dessa neoplasia, tais como freqüência, patogênese, apresentação clínica, histopatologia e evolução.We report the case of a 24-year-old patient who presented a left kidney tumor that was diagnosed as a medullary renal cell carcinoma. The following aspects of this neoplasia are discussed in this communication: frequency, pathogenesis, clinical presentation, histopathological findings, differential diagnosis and follow-up.

  3. Rimmed and edge thickened Stodola shaped flywheel

    Science.gov (United States)

    Kulkarni, Satish V. (San Ramon, CA); Stone, Richard G. (Oakland, CA)

    1983-01-01

    A flywheel (10) is described that is useful for energy storage in a hybrid vehicle automotive power system or in some stationary applications. The flywheel (10) has a body (15) composed of essentially planar isotropic high strength material. The flywheel (10) body (15) is enclosed by a rim (50) of circumferentially wound fiber (2) embedded in resin (3). The rim (50) promotes flywheel (10) safety and survivability. The flywheel (10) has a truncated and edge thickened Stodola shape designed to optimize system mass and energy storage capability.

  4. Bone tumor

    Science.gov (United States)

    Tumor - bone; Bone cancer; Primary bone tumor; Secondary bone tumor ... The cause of bone tumors is unknown. They often occur in areas of the bone that grow rapidly. Possible causes include: Genetic defects passed down ...

  5. The natural history of disappearing bone tumours and tumour-like conditions

    International Nuclear Information System (INIS)

    We describe 27 cases of bone tumours or tumour-like lesions where there was spontaneous regression. The follow-up period was 2.8-16.7 years (average, 7.0 years). Fourteen of these cases were no longer visible on plain radiographs. Histological diagnosis included exostosis, eosinophilic granuloma, fibrous dysplasia, fibrous cortical defect, non-ossifying fibroma, osteoid osteoma and bone island. Most cases began to reduce in adolescence or earlier, although sclerotic type lesions showed their regression in older patients. All lesions thought to be eosinophilic granuloma began to regress after periods of less than 3 months, while the duration of the other lesions showed wide variation (1-74 months). As resolution of the lesions took between 2 and 79 months (mean, 25.0 ± 20.3 months) we consider that the most likely mechanism was recovery of normal skeletal growth control. In exostosis with fracture, alteration of vascular supply may contribute to growth arrest, but not to subsequent remodelling stage. In inflammatory-related lesions such as eosinophilic granuloma, cessation of inflammation may be the mechanism of growth arrest, whilst temporary inflammation may stimulate osteogenic cells engaged in remodeling. In the sclerotic type, growth arrest is a less probable mechanism. Necrosis within the tumour and/or local changes in hormonal control, plus remodelling of the sclerotic area takes longer. Knowledge of the potential for spontaneous resolution may help in management of these tumour and tumour-like lesions of bone. Yanagawa, T. et al. (2001)

  6. The natural history of disappearing bone tumours and tumour-like conditions

    Energy Technology Data Exchange (ETDEWEB)

    Yanagawa, Takashi; Watanabe, Hideomi; Shinozaki, Tetsuya; Ahmed, Adel Refaat; Shirakura, Kenji; Takagishi, Kenji

    2001-11-01

    We describe 27 cases of bone tumours or tumour-like lesions where there was spontaneous regression. The follow-up period was 2.8-16.7 years (average, 7.0 years). Fourteen of these cases were no longer visible on plain radiographs. Histological diagnosis included exostosis, eosinophilic granuloma, fibrous dysplasia, fibrous cortical defect, non-ossifying fibroma, osteoid osteoma and bone island. Most cases began to reduce in adolescence or earlier, although sclerotic type lesions showed their regression in older patients. All lesions thought to be eosinophilic granuloma began to regress after periods of less than 3 months, while the duration of the other lesions showed wide variation (1-74 months). As resolution of the lesions took between 2 and 79 months (mean, 25.0 {+-} 20.3 months) we consider that the most likely mechanism was recovery of normal skeletal growth control. In exostosis with fracture, alteration of vascular supply may contribute to growth arrest, but not to subsequent remodelling stage. In inflammatory-related lesions such as eosinophilic granuloma, cessation of inflammation may be the mechanism of growth arrest, whilst temporary inflammation may stimulate osteogenic cells engaged in remodeling. In the sclerotic type, growth arrest is a less probable mechanism. Necrosis within the tumour and/or local changes in hormonal control, plus remodelling of the sclerotic area takes longer. Knowledge of the potential for spontaneous resolution may help in management of these tumour and tumour-like lesions of bone. Yanagawa, T. et al. (2001)

  7. Reaction kinetics of dolomite rim growth

    Science.gov (United States)

    Helpa, V.; Rybacki, E.; Abart, R.; Morales, L. F. G.; Rhede, D.; Je?ábek, P.; Dresen, G.

    2014-04-01

    Reaction rims of dolomite (CaMg[CO3]2) were produced by solid-state reactions at the contacts of oriented calcite (CaCO3) and magnesite (MgCO3) single crystals at 400 MPa pressure, 750-850 °C temperature, and 3-146 h annealing time to determine the reaction kinetics. The dolomite reaction rims show two different microstructural domains. Elongated palisades of dolomite grew perpendicular into the MgCO3 interface with length ranging from about 6 to 41 µm. At the same time, a 5-71 µm wide rim of equiaxed granular dolomite grew at the contact with CaCO3. Platinum markers showed that the original interface is located at the boundary between the granular and palisade-forming dolomite. In addition to dolomite, a 12-80 µm thick magnesio-calcite layer formed between the dolomite reaction rims and the calcite single crystals. All reaction products show at least an axiotactic crystallographic relationship with respect to calcite reactant, while full topotaxy to calcite prevails within the granular dolomite and magnesio-calcite. Dolomite grains frequently exhibit growth twins characterized by a rotation of 180° around one of the equivalent axis. From mass balance considerations, it is inferred that the reaction rim of dolomite grew by counter diffusion of MgO and CaO. Assuming an Arrhenius-type temperature dependence, activation energies for diffusion of CaO and MgO are E a (CaO) = 192 ± 54 kJ/mol and E a (MgO) = 198 ± 44 kJ/mol, respectively.

  8. Rim Sim: A Role-Play Simulation

    Science.gov (United States)

    Barrett, Robert C.; Frew, Suzanne L.; Howell, David G.; Karl, Herman A.; Rudin, Emily B.

    2003-01-01

    Rim Sim is a 6-hour, eight-party negotiation that focuses on creating a framework for the long-term disaster-recovery efforts. It involves a range of players from five countries affected by two natural disasters: a typhoon about a year ago and an earthquake about 6 months ago. The players are members of an International Disaster Working Group (IDWG) that has been created by an international commission. The IDWG has been charged with drawing up a framework for managing two issues: the reconstruction of regionally significant infrastructure and the design of a mechanism for allocating funding to each country for reconstruction of local infrastructure and ongoing humanitarian needs. The first issue will involve making choices among five options (two harbor options, two airport options, and one rail-line option), each of which will have three levels at which to rebuild. The second issue will involve five starting-point options. Participants are encouraged to invent other options for both issues. The goal of Rim Sim is to raise questions about traditional approaches to disaster-preparedness planning and reconstruction efforts in an international setting, in this case the Pacific Rim. Players must confront the reverberating effects of disasters and the problems of using science and technical information in decisionmaking, and are introduced to a consensus-building approach emphasizing face-to-face dialog and multinational cooperation in dealing with humanitarian concerns, as well as long-term efforts to reconstruct local and regional infrastructure. The Rim Sim simulation raises four key points: ripple effects of disasters, role of science, multiparty negotiation, and building personal relationships.

  9. Time course of X-ray pecture of thyroid cancer metstases to the bones resulting from radiotherapy effects

    International Nuclear Information System (INIS)

    Teletherapy or radiotherapy combined with 131I for thyroid cancer metastases to the bones caused the development of bone reparation in 70%, in 17% the picture remained unchanged; signs of further tumor growth were observed in 13%. An early X-ray sign of therapeutic efficacy was the decreased soft tissue component of a metastatic tumor 3-5 mos after the initiation of therapy. Disease stabilization was observed in 2.5-3 yrs. X-ray manifestations of bone reparation looked as sclerotic changes along the periphery of a focus of lesion and depended on the sizes of a metastasis and its localization in the skeleton

  10. The nature and origin of rims on lunar soil grains

    Science.gov (United States)

    Keller, Lindsay P.; McKay, David S.

    1997-06-01

    Space weathering processes that operate in the lunar regolith modify the surfaces of lunar soil grains. Transmission electron microscope analysis of the lunar soil grains from the fine size fraction of several lunar soils show that most grains are surrounded by thin (60-200 nm thick) rims. The microstructure and chemical compositions of the rims can be used to classify rims into four broad categories: amorphous, inclusion-rich, multiple, and vesicular. Amorphous rims are noncrystalline, generally lack crystalline inclusions, show evidence for preferential sputtering of cations, and are produced largely by solar-wind irradiation damage. Inclusion-rich rims contain abundant nanometer-sized grains of Fe metal as randomly dispersed inclusions or as distinct layers embedded in an amorphous silica-rich matrix. Inclusion-rich rims are compositionally distinct from their host grains and typically contain accumulations of elements that are not indigenous to the host. Inclusion-rich rims are formed largely by the deposition of impact-generated vapors with a contribution from the deposition of sputtered ions. A continuum in the chemical and microstructural properties exists between typical amorphous rims and typical inclusion-rich rims. Multiple-rims consist of a distinct radiation-damaged layer up to 50 nm thick, that is overlain by vapor-deposited material of comparable thickness. Vesicular rims are compositionally similar to their hosts and are characterized by an abundance of small (effects may be superimposed. From this study, it is shown that one process does not dominate and that the relative importance of vapor-deposition is comparable to radiation-damage in the formation of rims on lunar silicate grains. The presence of rims on lunar soil grains, particularly those with nanometer-sized Fe metal inclusions, may have a major influence on the optical and magnetic properties of lunar soils.

  11. Aquaporin-4 expression in distal myopathy with rimmed vacuoles

    OpenAIRE

    Hoshi Akihiko; Yamamoto Teiji; Kikuchi Saeko; Soeda Tomoko; Shimizu Keiko; Ugawa Yoshikazu

    2012-01-01

    Abstract Background Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles. To date, the role of aquaporin-4 water channel in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy has not been studied. Case presentation Here, we studied the expression of aquaporin-4 in muscle fibers of a patient...

  12. Aquaporin-4 expression in distal myopathy with rimmed vacuoles

    Directory of Open Access Journals (Sweden)

    Hoshi Akihiko

    2012-04-01

    Full Text Available Abstract Background Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles. To date, the role of aquaporin-4 water channel in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy has not been studied. Case presentation Here, we studied the expression of aquaporin-4 in muscle fibers of a patient with distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy. Immunohistochemical and immunofluorescence analyses showed that sarcolemmal aquaporin-4 immunoreactivity was reduced in many muscle fibers of the patient. However, the intensity of aquaporin-4 staining was markedly increased at rimmed vacuoles or its surrounding areas and in some muscle fibers. The fast-twitch type 2 fibers were predominantly involved with the strong aquaporin-4-positive rimmed vacuoles and TAR-DNA-binding protein-43 aggregations. Rimmed vacuoles with strong aquaporin-4 expression seen in the distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy patient were not found in control muscles without evidence of neuromuscular disorders and the other disease-controls. Conclusions Aquaporin-4 might be crucial in determining the survival or degeneration of fast-twitch type 2 fibers in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy.

  13. Candida albicans Rim13p, a Protease Required for Rim101p Processing at Acidic and Alkaline pHs

    OpenAIRE

    Li, Mingchun; Martin, Samuel J.; Bruno, Vincent M; Mitchell, Aaron P.; Davis, Dana A

    2004-01-01

    Candida albicans is an important commensal of mucosal surfaces that is also an opportunistic pathogen. This organism colonizes a wide range of host sites that differ in pH; thus, it must respond appropriately to this environmental stress to survive. The ability to respond to neutral-to-alkaline pHs is governed in part by the RIM101 signal transduction pathway. Here we describe the analysis of C. albicans Rim13p, a homolog of the Rim13p/PalB calpain-like protease member of the RIM101/pacC path...

  14. Interesting bone scans - unusual findings

    International Nuclear Information System (INIS)

    A 59-year-old female with carcinoma of the colon and known liver metastatic disease was referred for bone scan to evaluate for bone metastases. Although no bone metastases were found, there was abnormal uptake noted in the liver corresponding to a metastatic calcified lesion. The only other findings were of degenerative disease in the cervical spine, right shoulder and small joints of the hands. A 69-year-old male with carcinoma of the prostate and right side low back pain was referred for bone scan. No focal abnormalities to suggest metastatic disease were identified; findings within the cervical spine, lumber spine and knees were presumed secondary to degenerative disease. Intermittent pain persisted and the patient was referred for a repeat bone scan six months later. Previous scan findings of degenerative disease and no metastatic disease were confirmed; however, closer inspection revealed an enlarged right kidney with significant retention of tracer in the pelvicalyceal system suggesting possible obstruction. A Retrograde pyelogram was performed, and no obvious obstruction demonstrated. As bone scan findings were very suggestive of obstruction, a DTPA scan with lasix was performed showing a dilated right collecting system with no functional obstruction. Given the degree of dilation, it is possible that the patient experiences intermittent PUJ obstruction causing his symptoms. A 33-year-old male with insulin dependent diabetes mellitus and viral arthritis was referred for a bone scan. A three phase revealed increased uptake in the region of the knee and leR proximal tibia. Delayed whole body images revealed multiple focal areas of osteoblastic activity in the leR tibia. Abnormal uptake was also seen in the upper third of the leR femur. The remainder of the skeletal survey was normal. X-ray correlation of the leR tibia and femoral findings was undertaken. Combinating unilateral changes on bone scan and X-ray although very suggestive of sclerotic polyostotic fibrous dysplasia. Three cases with interesting and unusual bone scan findings assisted in further management and treatment of patients

  15. Interesting bone scans - unusual findings

    Energy Technology Data Exchange (ETDEWEB)

    Dobson, M.; Wadhwa, S.S.; Mansberg, R.; Fernandes, V.B. [Wollongong Hospital, Wollongong, NSW (Australia)

    1997-12-01

    A 59-year-old female with carcinoma of the colon and known liver metastatic disease was referred for bone scan to evaluate for bone metastases. Although no bone metastases were found, there was abnormal uptake noted in the liver corresponding to a metastatic calcified lesion. The only other findings were of degenerative disease in the cervical spine, right shoulder and small joints of the hands. A 69-year-old male with carcinoma of the prostate and right side low back pain was referred for bone scan. No focal abnormalities to suggest metastatic disease were identified; findings within the cervical spine, lumber spine and knees were presumed secondary to degenerative disease. Intermittent pain persisted and the patient was referred for a repeat bone scan six months later. Previous scan findings of degenerative disease and no metastatic disease were confirmed; however, closer inspection revealed an enlarged right kidney with significant retention of tracer in the pelvicalyceal system suggesting possible obstruction. A Retrograde pyelogram was performed, and no obvious obstruction demonstrated. As bone scan findings were very suggestive of obstruction, a DTPA scan with lasix was performed showing a dilated right collecting system with no functional obstruction. Given the degree of dilation, it is possible that the patient experiences intermittent PUJ obstruction causing his symptoms. A 33-year-old male with insulin dependent diabetes mellitus and viral arthritis was referred for a bone scan. A three phase revealed increased uptake in the region of the knee and leR proximal tibia. Delayed whole body images revealed multiple focal areas of osteoblastic activity in the leR tibia. Abnormal uptake was also seen in the upper third of the leR femur. The remainder of the skeletal survey was normal. X-ray correlation of the leR tibia and femoral findings was undertaken. Combinating unilateral changes on bone scan and X-ray although very suggestive of sclerotic polyostotic fibrous dysplasia. Three cases with interesting and unusual bone scan findings assisted in further management and treatment of patients

  16. Radiography, Bone Scan, and F-18 FDG PET/CT Imaging Findings in a Patient with Paget's Disease

    International Nuclear Information System (INIS)

    Background A 52-year-old female patient sought evaluation at our hospital for an incidental abnormal finding on an abdominal radiograph. The initial radiograph showed irregular sclerotic changes involving the right pelvic bone. At the same time, bone scintigraphy showed intense hot uptake in the right iliac and pubic bones. CT images showed characteristic thickening of the pelvic brim, suggesting the mixed phase of Paget's disease. The level of alkaline phosphatase (ALP) was 266 IU/I. 18F-FDG PET/CT images also showed diffusely increased 18F-FDG uptake in the right pelvic bone. However, the findings of 18F-FDG PET/CT were less notable than those of bone scintigraphy. We report the imaging findings of a patient with Paget's disease evaluated by radiography, bone scintigraphy, and 18F-FDG PET/CT.

  17. Visual illusions and plate design: The effects of plate rim widths and rim coloring on perceived food portion size

    Science.gov (United States)

    McClain, Arianna; van den Bos, Wouter; Matheson, Donna; Desai, Manisha; McClure, Samuel M.; Robinson, Thomas N.

    2013-01-01

    OBJECTIVE The Delboeuf Illusion affects perceptions of the relative sizes of concentric shapes. This study was designed to extend research on the application of the Delboeuf illusion to food on a plate by testing whether a plate’s rim width and coloring influence perceptual bias to affect perceived food portion size. DESIGN AND METHODS Within-subjects experimental design. Experiment 1 tested the effect of rim width on perceived food portion size. Experiment 2 tested the effect of rim coloring on perceived food portion size. In both experiments, participants observed a series of photographic images of paired, side-by-side plates varying in designs and amounts of food. From each pair, participants were asked to select the plate that contained more food. Multi-level logistic regression examined the effects of rim width and coloring on perceived food portion size. RESULTS Experiment 1: Participants overestimated the diameter of food portions by 5% and the visual area of food portions by 10% on plates with wider rims compared to plates with very thin rims (Peffect of rim width was greater with larger food portion sizes. Experiment 2: Participants overestimated the diameter of food portions by 1.5% and the visual area of food portions by 3% on plates with rim coloring compared to plates with no coloring (P=0.01). The effect of rim coloring was greater with smaller food portion sizes. CONCLUSION The Delboeuf illusion applies to food on a plate. Participants overestimated food portion size on plates with wider and colored rims. These findings may help design plates to influence perceptions of food portion sizes. PMID:24005858

  18. Bone sarcomas in Paget disease: a study of 85 patients

    International Nuclear Information System (INIS)

    This is a comprehensive review of 85 patients who had bone sarcoma associated with Paget disease and who were seen at Memorial Sloan-Kettering Cancer Center between 1927 and 1982. There was an almost equal distribution of tumors in the axial and the appendicular skeletons. The pelvis, humerus, femur, and skull were the tumor sites in 80% of cases. The tumors were bulky large soft tissue masses. Lytic lesions were more common than sclerotic lesions. Methylene diphosphonate scans of the bone often showed a cold area that was associated with marked increase in uptake on the gallium scan. Angiography, which was performed in 13 patients, was useful, but CT was much more helpful in showing the soft tissue mass as well as the extent of bony disease. Only three patients in this study survived for five years

  19. Business Strategy Analysis of RIM in China's Smartphone Industry

    OpenAIRE

    Chen, Lei

    2011-01-01

    China, the biggest mobile phone market in the world, is crucial for the future of Research In Motion (RIM). While RIM entered China’s market in 2006, its market share is still very small in China. The launch of 3G amid the restructuring of China’s telecom industry proved crucial to the company’s development. RIM has partnered with all mobile operators in China to provide BlackBerry Enterprise Service and BlackBerry Internet Service to both business and individual users. It has gained a compet...

  20. Bone Diseases

    Science.gov (United States)

    Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly ... childhood and your teens, your body adds new bone faster than it removes old bone. After about ...

  1. Bone Tumor

    Science.gov (United States)

    ... tumor • Enchondroma • Fibrous dysplasia • Chondroblastoma • Aneurysmal bone cyst • Osteoid osteoma Cause For most bone tumors, the cause is ... benign tumors that occur in children, such as osteoid osteoma. Bone Tumor cont. Femur (thighbone) tumor. This x- ...

  2. Bone Cancer

    Science.gov (United States)

    Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another ... more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and ...

  3. Rimmed and edge thickened stodola shaped flywheel. [Patent application

    Science.gov (United States)

    Kulkarni, S.V.; Stone, R.G.

    1980-09-24

    A flywheel is described that is useful for energy storage in a hybrid vehicle automotive power system or in some stationary applications. The flywheel has a body composed of essentially planar isotropic high strength material. The flywheel body is enclosed by a rim of circumferentially wound fiber embedded in resin. The rim promotes flywheel safety and survivability. The flywheel has a truncated and edge thickened Stodola shape designed to optimize system mass and energy storage capability.

  4. Radiography, Bone Scan, and F-18 FDG PET/CT Imaging Findings in a Patient with Paget's Disease

    Energy Technology Data Exchange (ETDEWEB)

    Park, Eun Tae; Kim, Sung Eun [Korea University Guro Hospital, Seoul (Korea, Republic of)

    2010-04-15

    Background A 52-year-old female patient sought evaluation at our hospital for an incidental abnormal finding on an abdominal radiograph. The initial radiograph showed irregular sclerotic changes involving the right pelvic bone. At the same time, bone scintigraphy showed intense hot uptake in the right iliac and pubic bones. CT images showed characteristic thickening of the pelvic brim, suggesting the mixed phase of Paget's disease. The level of alkaline phosphatase (ALP) was 266 IU/I. {sup 18}F-FDG PET/CT images also showed diffusely increased {sup 18}F-FDG uptake in the right pelvic bone. However, the findings of {sup 18}F-FDG PET/CT were less notable than those of bone scintigraphy. We report the imaging findings of a patient with Paget's disease evaluated by radiography, bone scintigraphy, and {sup 18}F-FDG PET/CT.

  5. Rim region growth and its composition in reaction bonded boron carbide composites with core-rim structure

    International Nuclear Information System (INIS)

    Aluminum was detected in reaction-bonded boron carbide that had been prepared by pressureless infiltration of boron carbide preforms with molten silicon in a graphite furnace under vacuum. The presence of Al2O3 in the heated zone, even though not in contact with the boron carbide preform, stands behind the presence of aluminium in the rim region that interconnects the initial boron carbide particles. The composition of the rim corresponds to the Bx(C,Si,Al)y quaternary carbide phase. The reaction of alumina with graphite and the formation of a gaseous aluminum suboxide (Al2O) accounts for the transfer of aluminum in the melt and, subsequently in the rim regions. The presence of Al increases the solubility of boron in liquid silicon, but with increasing aluminum content the activity of boron decreases. These features dominate the structural evolution of the rim-core in the presence of aluminum in the melt.

  6. Learning from California and the Pacific Rim

    International Nuclear Information System (INIS)

    Heavy oils are found in 10 of the 14 largest oilfields in Alaska and California. In the US west coast region, petroleum demand is dominated by light transport fuels, and there is a lack of a discrete and conspicuous heavy oil market. The structure and behavior of west coast petroleum markets, and their interactions with crude-oil and petroleum product markets elsewhere on the Pacific Rim are discussed with regard to how the market for growing volumes of western Canadian heavy oils might evolve. An analysis of crude oil prices versus API gravity demonstrates the price penalties on oil of low gravity, high sulfur, and high transport cost. Prices at the high gravity end tend to correlate closely with Asian light crude and unfinished gasoline prices. The heaviest crudes are priced in competition with other chemically similar residual oils for direct fuel use, blending, or refinery feedstock. The biggest component of the west coast heavy oil market is bunker fuel. The market value of heavy crudes in the west coast is thus determined by regional supply and demand for heavy hydrocarbon molecules, whatever the source. The west coast is not a promising market for Canadian heavy crudes, and exports to Asia would have to compete both with residual oils from Asia and the US west coast and with California heavy crudes. US west coast production peaked in 1989 and regional production can be expected to decline further in average gravity. New production from known but undeveloped heavy oil pools near Prudhoe Bay or in the California offshore could be expected to postpone the need for imports to the west coast and to depress prices. A removal of the Alaska crude oil export ban could improve the west coast heavy oil market. 5 refs., 2 figs., 1 tab

  7. Histologia e ultraestrutura do rim e rim cefálico do pacu Histology and ultrastructure of kidney and cephalic kidney in Pacu

    OpenAIRE

    Gerlane M. Costa; Ana R de Lima; Mendelson G. de Lima; José R. Kfoury Jr

    2012-01-01

    O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de...

  8. Prostate cancer with lytic bone metastases: 18F-fluorodeoxyglucose positron emission tomography-computed tomography for diagnosis and monitoring response to medical castration therapy

    International Nuclear Information System (INIS)

    Lytic bone metastases are rare in prostate cancer. We here present 18 fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography computed tomography (PET-CT) images of a 67-year-old male patient with lytic metastases from prostate cancer. Repeat 18F-FDG PET-CT done 6 months later showed response to medical castration therapy. While the role of 18F-FDG PET-CT for sclerotic bone metastases in prostate cancer remains controversial, it appears to be useful for detection and response assessment of lytic prostate cancer metastases. (author)

  9. Does rim microstructure formation degrade the fuel rod performance?

    International Nuclear Information System (INIS)

    High burnup extension of LWR fuel is progressing to reduce the total process flow and eventually the costs of the nuclear fuel cycle. A particular fuel restructuring at high burnups, commonly observed at the periphery of LWR fuel pellets (rim structure), but also in FBR fuels to some extent and in the Plutonium rich clusters of the MOX Fuels, was considered a priori as a limitation for burnup extension. Since more than ten years this rim effect have been deeply investigated. Its causes and consequences are however not yet totally elucidated. The three steps actually identified of this phenomenon are first a progressive disappearing of the intra-granular Xenon, the outset of numerous 0.5 to 1 m pores and finally a grain subdivision around the pores. Penalty of the porosity increase on the thermal conductivity is obvious. One expect the fission gases to remain trapped in the rim porosity up to a 75 MWd/kgUO2 local burnup. Above this threshold, 15 to 20 % of the fission gases seem to be quickly released. Microindentation tests conducted at ITU have shown the rim structure to resist fracture extension under punching. It is still open whether this implies certain ductility and viscosity of the material, or if it corresponds to stress relaxation by microcracking. Whatever the case be, it is suggested that the rim material would be able to decrease the interaction stresses and to equalise the cladding strains during a power ramp. Moreover, in the RIA tests, it was concluded so far that the grain de-cohesion caused by gas expansion at the grain boundaries was responsible for the cladding strain and failure. However, not the rim zone was affected by grain de-cohesion but the region adjacent to it. Therefore, in front of the question whether the rim structure degrades the fuel rod behaviour, we continue to argue on its benefit for fuel burnup extension. (author)

  10. Subchondral bone failure in overload arthrosis: a scanning electron microscopic study in horses.

    Science.gov (United States)

    Norrdin, R W; Stover, S M

    2006-01-01

    Mechanical overload leads to a common arthrosis in the metacarpal condyle of the fetlock joint of racehorses. This is usually asymptomatic but severe forms can cause lameness. Subchondral bone failure is often present and the predictability of the site provided an opportunity to study of the progression of bone failure from microcracks to actual collapse of subchondral bone. Twenty-five fetlock condyles from racehorses with various stages of disease were selected. Stages ranged from mild through severe subchondral bone sclerosis, to the collapse of bone and indentation or loss of cartilage known as 'traumatic osteochondrosis'. Parasagittal slices were radiographed and examined with scanning electron microscopy. Fine matrix cracks were seen in the subchondral bone layer above the calcified cartilage and suggested loss of water or other non-collagenous components. The earliest microcracks appeared to develop in the sclerotic bone within 1-3 mm of the calcified cartilage layer and extend parallel to it in irregular branching lines. Longer cracks or microfractures appeared to develop gaps as fragmentation occurred along the margins. Occasional osteoclastic resorption sites along the fracture lines indicated activated remodeling may have caused previous weakening. In one sample, smoothly ground fragments were found in a fracture gap. Bone collapse occurred when there was compaction of the fragmented matrix along the microfracture. Bone collapse and fracture lines through the calcified cartilage were associated with indentation of articular cartilage at the site. PMID:17142946

  11. {sup 18}F-FDG PET/CT bone/bone marrow findings in Hodgkin's lymphoma may circumvent the use of bone marrow trephine biopsy at diagnosis staging

    Energy Technology Data Exchange (ETDEWEB)

    Moulin-Romsee, Gerard [Universite Paris 7, Service de Medicine Nucleaire, Hopital Saint-Louis, Assistance Publique-Hopitaux de Paris (France); Institut Curie, Nuclear Medicine, Paris (France); Hindie, Elif; Filmont, Jean-Emmanuel; Moretti, Jean-Luc [Universite Paris 7, Service de Medicine Nucleaire, Hopital Saint-Louis, Assistance Publique-Hopitaux de Paris (France); Cuenca, Xavier; Brice, Pauline; Sibon, David [Hopital Saint-Louis, Haemato-Oncology, Paris (France); Decaudin, Didier; Anitei, Marcela [Institut Curie, Haematology, Paris (France); Benamor, Myriam [Institut Curie, Nuclear Medicine, Paris (France); Briere, Josette [Hopital Saint-Louis, Pathology, Paris (France); Kerviler, Eric de [Hopital Saint-Louis, Radiology, Paris (France)

    2010-06-15

    Accurate staging of Hodgkin's lymphoma (HL) is necessary in selecting appropriate treatment. Bone marrow trephine biopsy (BMB) is the standard procedure for depicting bone marrow involvement. BMB is invasive and explores a limited part of the bone marrow. {sup 18}F-FDG PET/CT is now widely used for assessing response to therapy in HL and a baseline study is obtained to improve accuracy. The aim of this retrospective analysis was to assess whether routine BMB remains necessary with concomitant {sup 18}F-FDG PET/CT. Data from 83 patients (newly diagnosed HL) were reviewed. All patients had received contrast-enhanced CT, BMB and {sup 18}F-FDG PET/CT. Results of BMB were not available at the time of {sup 18}F-FDG PET/CT imaging. Seven patients had lymphomatous involvement on BMB. Four patients had bone involvement on conventional CT (two with negative BMB). All patients with bone marrow and/or bone lesions at conventional staging were also diagnosed on {sup 18}F-FDG PET/CT scan. PET/CT depicted FDG-avid bone/bone marrow foci in nine additional patients. Four of them had only one or two foci, while the other had multiple foci. However, the iliac crest, site of the BMB, was not involved on {sup 18}F-FDG PET/CT. Osteolytic/sclerotic lesions matching FDG-avid foci were visible on the CT part of PET/CT in three patients. MRI ordered in three other patients suggested bone marrow involvement. Interim and/or end-therapy {sup 18}F-FDG PET/CT documented response of FDG-avid bone/bone marrow foci to chemotherapy in every patient. {sup 18}F-FDG PET/CT highly improves sensitivity for diagnosis of bone/bone marrow lesions in HL compared to conventional staging. (orig.)

  12. Bone cement

    OpenAIRE

    Vaishya, Raju; Chauhan, Mayank; Vaish, Abhishek

    2013-01-01

    The knowledge about the bone cement is of paramount importance to all Orthopaedic surgeons. Although the bone cement had been the gold standard in the field of joint replacement surgery, its use has somewhat decreased because of the advent of press-fit implants which encourages bone in growth. The shortcomings, side effects and toxicity of the bone cement are being addressed recently. More research is needed and continues in the field of nanoparticle additives, enhanced bone–cement interface ...

  13. Aqueous Alteration of Endeavour Crater Rim Apron Rocks

    Science.gov (United States)

    Mittlefehldt, David W.; Ming, Douglas W.; Gellert, Ralf; Clark, Benton C.; Morris, Richard V.; Yen, Albert S.; Arvidson, Raymond E.; Crumpler, Larry S.; Farrand, William H.; Grant, John A.; Jolliff, Bradley L.; Parker, Timothy J.; Peretyazhko, Tanya

    2014-01-01

    Mars Exploration Rover Opportunity is exploring Noachian age rocks of the rim of 22 km diameter Endeavour crater. Overlying the pre-impact lithologies and rim breccias is a thin apron of fine-grained sediments, the Grasberg fm, forming annuli on the lower slopes of rim segments. Hesperian Burns fm sandstones overly the Grasberg fm. Grasberg rocks have major element compositions that are distinct from Burns fm sandstones, especially when comparing interior compositions exposed by the Rock Abrasion Tool. Grasberg rocks are also different from Endeavour rim breccias, but have general compositional similarities to them. Grasberg sediments are plausibly fine-grained materials derived from the impact breccias. Veins of CaSO4 transect Grasberg fm rocks demonstrating post-formation aqueous alteration. Minor/trace elements show variations consistent with mobilization by aqueous fluids. Grasberg fm rocks have low Mn and high Fe/Mn ratios compared to the other lithologies. Manganese likely was mobilized and removed from the Grasberg host rock by redox reactions. We posit that Fe2+ from acidic solutions associated with formation of the Burns sulfate-rich sandstones acted as an electron donor to reduce more oxidized Mn to Mn2+. The Fe contents of Grasberg rocks are slightly higher than in other rocks suggesting precipitation of Fe phases in Grasberg materials. Pancam spectra show that Grasberg rocks have a higher fraction of ferric oxide minerals than other Endeavour rim rocks. Solutions transported Mn2+ into the Endeavour rim materials and oxidized and/or precipitated it in them. Grasberg has higher contents of the mobile elements K, Zn, Cl, and Br compared to the rim materials. Similar enrichments of mobile elements were measured by the Spirit APXS on West Spur and around Home Plate in Gusev crater. Enhancements in these elements are attributed to interactions of hydrothermal acidic fluids with the host rocks. Interactions of fluids with the Grasberg fm postdate the genesis of the Endeavour rim phyllosilicates. The aqueous alteration history of Endeavour rim rocks is complicated by different styles of alteration that have spanned the Noachian and Hesperian. Late stage acidic aqueous alteration of Grasberg fm materials is likely penecontemporaneous with the diagenesis of the sulfate-rich sediments of Meridiani Planum.

  14. Enchondroma on bone scan in a patient with breast cancer

    International Nuclear Information System (INIS)

    A 45-year-old postmenopausal woman with breast cancer was treated with modified radical mastectomy and radiotherapy. She remained clinically well for two years but then complained of pain in the left upper arm during a routine follow-up visit with her physician. A roentgenogram of the left proximal humerus showed a densely sclerotic, nonhomogeneous, 2 x 6 cm lesion with stippled calcification, the appearance of which was most consistent with a mature enchondroma or bone infarct. Because metastatic breast cancer was also a possibility, a technetium Tc 99m methyldiphosphonate (MDP) bone scan was done, revealing diffuse uptake in the left proximal humeral lesion, without any other area of involvement. Although radiologically the lesion appeared benign and stable, the history of breast cancer, abnormal bone scan, and pain could not be ignored, and open surgical bone biopsy was done. From deep within the lesion at the core of the metaphysis of the proximal left humerus, the surgeon removed an enchondroma, but found no evidence of metastatic disease. Follow-up MDP bone scans after six months and four years were unchanged

  15. Soft tissue aneurysmal bone cyst

    Energy Technology Data Exchange (ETDEWEB)

    Wang, X.L.; Gielen, J.L.; Delrue, F.; De Schepper, A.M.A. [Department of Radiology, Universitair Ziekenhuis Antwerpen (University of Antwerp), Wilrijkstraat 10, 2650, Edegem (Belgium); Salgado, R. [Department of Pathology, Universitair Ziekenhuis Antwerpen (University of Antwerp), Wilrijkstraat 10, 2650, Edegem (Belgium)

    2004-08-01

    A soft tissue aneurysmal bone cyst located in the right gluteus medius of a 21-year-old man is reported. On conventional radiography, the lesion demonstrated a spherically trabeculated mass with a calcific rim. On CT scan, it showed a well-organized peripheral calcification resembling a myositis ossificans. On MRI, it presented as a multilocular, cystic lesion with fluid-fluid levels. The lesion had no solid components except for intralesional septa. Although findings on imaging and histology were identical to those described in classical aneurysmal bone cyst, diagnosis was delayed because of lack of knowledge of this entity and its resemblance to the more familiar post-traumatic heterotopic ossification (myositis ossificans). (orig.)

  16. Low Bone Density (Osteopenia)

    Science.gov (United States)

    ... are here Home » Low Bone Density Low Bone Density Low bone density is when your bone density ... people with normal bone density. Detecting Low Bone Density A bone density test will determine whether you ...

  17. Detection of bone metastases in patients with prostate cancer by 18F fluorocholine and 18F fluoride PET-CT: a comparative study

    International Nuclear Information System (INIS)

    The aim of this prospective study was to compare the potential value of 18F fluorocholine (FCH) and 18F fluoride positron emission tomography (PET)-CT scanning for the detection of bony metastases from prostate cancer. Thirty-eight men (mean age, 69±8 years) with biopsy-proven prostate cancer underwent both imaging modalities within a maximum interval of 2 weeks. Seventeen patients were evaluated preoperatively, and 21 patients were referred for post-operative evaluation of suspected recurrence or progression based on clinical algorithms. The number, sites and morphological patterns of bone lesions on 18F FCH and 18F fluoride PET-CT were correlated: Concordant lesions between the two modalities with corresponding changes on CT were considered to be positive for malignancy; discordant lesions were verified by follow-up examinations. The mean follow-up interval was 9.1 months. Overall, 321 lesions were evaluated in this study. In a lesion-based analysis, a relatively close agreement was found between these two imaging modalities for detection of malignant bone lesions (kappa=0.57), as well as in a patient-based analysis (kappa=0.76). Sixteen malignant sclerotic lesions with a high density were negative in both 18F FCH and 18F fluoride PET-CT [ mean Hounsfield unit (HU), 1,148±364]. There was also a significant correlation between tracer intensity by SUV and density of sclerotic lesions by HU both in 18F FCH PET-CT (r=-0.28, p18F fluoride PET-CT (r=-0.20, p18F fluoride, and 74% (p=0.12), 99% (p=0.01) and 85% for FCH, respectively. 18F FCH PET-CT led to a change in the management in two out of 38 patients due to the early detection of bone marrow metastases. 18F fluoride PET-CT identified more lesions in some patients when compared with 18F FCH PET-CT but did not change patient management. FCH PET-CT may be superior for the early detection (i.e. bone marrow involvement) of metastatic bone disease. In patients with FCH-negative suspicious sclerotic lesions, a second bone-seeking agent (e.g. 18F fluoride) is recommended. 18F fluoride PET-CT demonstrated a higher sensitivity than 18F FCH PET-CT, but the difference was not statistically significant. Furthermore, 18F fluoride PET could be also negative in highly dense sclerotic lesions, which presumably reflects the effect of treatment. It will be important to clarify in future studies whether these lesions are clinically relevant when compared with metabolically active bone metastases. (orig.)

  18. Pacific Rim coal trade model for U.S. involvement

    International Nuclear Information System (INIS)

    The world contains 700 billion tons of coal reserves mineable by today's technical standards with the United States having one-third of the total. Coal demand of the Pacific Rim will grow very rapidly in the next decade due to expanded use of coal to produce electricity and steel. Imported 1989 coal supply to the Pacific Rim was from Australia (50%), Canada (18%), U.S. (13%), South Africa (7%), U.S.S.R. (6%), China (4%) and Indonesia (1%). The U.S. coal price will continue to trend downward due to increasing mine productivity. The world is moving toward a transnational economy. Groups of nations are forming economic ties and cooperation. This paper reports that the U.S. can increase involvement in the Pacific Rim coal markets by offering value-added coal sales transactions and by understanding Orient culture

  19. Observations of neutral carbon in the NGC 1977 bright rim

    Science.gov (United States)

    Wootten, A.; Phillips, T. G.; Beichman, C. A.; Frerking, M.

    1982-01-01

    Strong neutral carbon emission at 610 microns (492 GHz) has been detected from a bright-rimmed cloud abutting the H II region NGC 1977. The similarity of velocity and width between (C-13)O and C I lines suggests that both lines originate in the same region. A model for the density and temperature structure of the cloud, based on (C-13)O and (C-12)O observations, has been used to estimate the carbon abundance. The abundances of both C I and (C-13)O increase with depth into the cloud away from the rim. The carbon abundance reaches its peak value nearer the rim than does the (C-13)O abundance. This variation in the relative abundance distributions of CO and C I confirms the importance of photodissociation in the chemistry of molecular clouds, and of the C I line to studies of the interaction of hot stars with clouds.

  20. Experimental study of a TAHGEM detector with mini-rims

    International Nuclear Information System (INIS)

    The gas gain and energy resolution of single and double THGEM detectors (5 cm × 5 cm effective area) with mini-rims (rim less than 10 ?m) were studied. The maximum gain was found to reach 5 × 103 and 2 × 105 for single and double THGEMs respectively, while the energy resolution for 5.9 keV X-rays varied from 18% to 28% for both single and double THGEM detectors of different hole sizes and thicknesses. Different combinations were also investigated of noble gases (argon, neon) mixed with a quantity of other gases (isobutane, methane) at atmospheric pressure. (authors)

  1. "Repair of cranial bone defects using endochondral bone matrix gelatin in rat "

    Directory of Open Access Journals (Sweden)

    "Sobhani A

    2001-05-01

    Full Text Available Bone matrix gelatin (BMG has been used for bone induction intramuscularly and subcutaneously by many investigators since 1965. More recently, some of the researchers have used BMG particles for bone repair and reported various results. In present study for evaluation of bone induction and new bone formation in parital defects, BMG particles were used in five groups of rats. The BMG was prepared as previously described using urist method. The defects wee produced with 5 –mm diameter in pariteal bones and filled by BMG particles. No BMG was used in control group.For evaluation of new bone formation and repair, the specimens were harvested on days 7 , 14 , 21 and 28 after operation. The samples were processed histologically, stained by H& E, alizarin red S staining, and Alcian blue, and studied by a light microscope.The results are as follows:In control group: Twenty-eight days after operation a narrow rim of new bone was detectable attached to the edge of defect.In BMG groups: At day 7 after operation young chondroblast cells appeared in whole area of defect. At 14th day after operation hypertrophic chondrocytes showed by Alcian blue staining and calcified cartilage were detectable by Alizarin red S staining. The numerous trabeculae spicules, early adult osteocytes and highly proliferated red bone marrow well developed on dayd 21 . finally typic bone trabeculae with regulated osteoblast cells and some osteoclast cells were detectable at day 28 after operation. In conclusion,BMG could stimulate bone induction and new bone formation in bony defects. So, it seems that BMG could be a godd biomaterial substance for new bone inducation in bone defects

  2. Imaging features of low-grade central osteosarcoma of the long bones and pelvis

    International Nuclear Information System (INIS)

    To determine the age and gender distribution and imaging features of low-grade central osteosarcoma (LGCOS) of the long bones and pelvis and to discuss our findings in the context of lesions for which LGCOS has been mistaken. We reviewed 99 cases of LGCOS collected between 1919 and 2002 from our institution and pathology consultation files. Adequate imaging was available in 70 cases (36 radiographs only, 17 radiographs/CT, 12 radiographs/MRI, 2 radiographs/CT/MRI, 2 CT only, 1 MRI only, 5 bone scans). Patient average age was 30.1±14.2 years, with a slight female predominance. The femur and tibia were the most common long bones involved (29 and 20 each) with the majority of these tumors arising around the knee, followed by the fibula, radius, humerus and ulna (four, three, two and one case each). Flat bones were involved in six cases (three pelvis, one rib, two scapulae). Short tubular bones were involved in five cases (two metatarsal, two phalanges, one clavicle). The lesion extended to the end of the affected long bone in 22 of 59 cases. Lesions were large at presentation (mean 7.9±4.6 cm, range 2-24). Four radiographic patterns were identified: lytic with varying amounts of thick and coarse trabeculation (n=22), predominantly lytic with few thin, incomplete trabecula (n=21), densely sclerotic (n=17) and mixed lytic and sclerotic (n=10). Lesions were benign-appearing overall with focally aggressive features. CT or MRI demonstrated cortical breech or extension into the soft tissues in all cases. LGCOS has a variable appearance on radiographs. A frequent pattern is a slow-growing large intracompartmental fibro-osseous lesion with varying amounts of septal ossification associated with focal areas of aggression. A homogeneously sclerotic pattern was also noted. Imaging with CT or MRI was helpful in every instance in our series in identifying areas of soft tissue extension or cortical disruption suggestive of a low-grade malignancy. (orig.)

  3. Imaging features of low-grade central osteosarcoma of the long bones and pelvis

    Energy Technology Data Exchange (ETDEWEB)

    Andresen, Kelli J.; Sundaram, Murali [Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN (United States); Unni, K. Krishnan [Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN (United States); Sim, Franklin H. [Department of Orthopedic Surgery, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN (United States)

    2004-07-01

    To determine the age and gender distribution and imaging features of low-grade central osteosarcoma (LGCOS) of the long bones and pelvis and to discuss our findings in the context of lesions for which LGCOS has been mistaken. We reviewed 99 cases of LGCOS collected between 1919 and 2002 from our institution and pathology consultation files. Adequate imaging was available in 70 cases (36 radiographs only, 17 radiographs/CT, 12 radiographs/MRI, 2 radiographs/CT/MRI, 2 CT only, 1 MRI only, 5 bone scans). Patient average age was 30.1{+-}14.2 years, with a slight female predominance. The femur and tibia were the most common long bones involved (29 and 20 each) with the majority of these tumors arising around the knee, followed by the fibula, radius, humerus and ulna (four, three, two and one case each). Flat bones were involved in six cases (three pelvis, one rib, two scapulae). Short tubular bones were involved in five cases (two metatarsal, two phalanges, one clavicle). The lesion extended to the end of the affected long bone in 22 of 59 cases. Lesions were large at presentation (mean 7.9{+-}4.6 cm, range 2-24). Four radiographic patterns were identified: lytic with varying amounts of thick and coarse trabeculation (n=22), predominantly lytic with few thin, incomplete trabecula (n=21), densely sclerotic (n=17) and mixed lytic and sclerotic (n=10). Lesions were benign-appearing overall with focally aggressive features. CT or MRI demonstrated cortical breech or extension into the soft tissues in all cases. LGCOS has a variable appearance on radiographs. A frequent pattern is a slow-growing large intracompartmental fibro-osseous lesion with varying amounts of septal ossification associated with focal areas of aggression. A homogeneously sclerotic pattern was also noted. Imaging with CT or MRI was helpful in every instance in our series in identifying areas of soft tissue extension or cortical disruption suggestive of a low-grade malignancy. (orig.)

  4. Bone Infections

    Science.gov (United States)

    ... of the body, bones can get infected. The infections are usually bacterial, but can also be fungal. ... bloodstream. People who are at risk for bone infections include those with diabetes, poor circulation, or recent ...

  5. Bone scan

    Science.gov (United States)

    ... injecting a very small amount of radioactive material (radiotracer) into a vein. The substance travels through your ... body. The camera takes pictures of how much radiotracer collects in the bones. If a bone scan ...

  6. Structural Rim Uplift and Ejecta Thickness Measurements of Complex Martian and Lunar Impact Craters

    Science.gov (United States)

    Sturm, S.; Krüger, T.; Kenkmann, T.

    2015-09-01

    We analyzed twelve martian and five lunar complex impact craters regarding their structural rim uplift and ejecta thickness along their final crater rims. Additionally, we reconstructed the transient crater cavity sizes of these craters.

  7. The Rim Trail at Pipe Spring National Monument, Arizona (pisp_trail)

    Data.gov (United States)

    National Park Service, Department of the Interior — This is an Arc/Info coverage consisting of 4 arcs representing The Rim Trail at Pipe Spring National Monument, Arizona. The Rim Trail was collected by a Trimble...

  8. Origin of strongly reversed rims on plagioclase in cumulates

    Science.gov (United States)

    Morse, S. A.; Nolan, Kathleen M.

    1984-06-01

    Narrow reversed rims on plagioclase are ubiquitous in troctolites and olivine gabbros of the Kiglapait intrusion and may be a common feature of all such cumulates. The rims occur at plag/plag, plag/ol, and less strongly at plag/aug grain boundaries. They are optically obvious at ?An 30 can easily be achieved by such a process. It is also probable that the trapped liquid is part of an An-rich boundary layer generated by solute rejection during adcumulus growth. The ability of the rims to sustain steep K/Na gradients despite a long subsolidus cooling history proves that the K sbnd Na exchange rate is vanishingly small over a geologic time scale in An-rich feldspar, suggesting that at low K content the potassium is site-bound to the tetrahedral Al/Si distribution. Reversed rims therefore provide important information on diffusion limits as well as on the late-stage solidification history of plagioclase-rich cumulates. Moreover, they demonstrate that plagioclase geothermometry cannot be divorced from effects of liquid composition and structure as monitored, for example, by augite content.

  9. Ultrasensitive analysis of thorium by resonance ionization mass spectroscopy (RIMS)

    International Nuclear Information System (INIS)

    This communication presents results on a RIMS analysis of thorium. Thorium is of interest for geochronological and geochemical purposes. The measurement of uranium series disequilibrium is a well established and valuable approach for geochronological studies: disequilibrium between 234/238U and 230Th can be used to date samples younger than 350,000 years. Both continuous wave (cw) and pulsed lasers were utilized in this study for resonantly exciting and subsequently ionizing thorium. In the case of the pulsed laser RIMS experiments, two excimer laser-pumped dye lasers were used in conjunction with a 0.4 m time-of-flight mass spectrometer. The cw RIMS experiments used an Ar+ laser-pumped dye laser and a second Ar+ in combination with a single magnetic sector mass spectrometer (NBS 12-90 design). Experiments performed with the pulsed RIMS apparatus were aimed at determining the autoionization state structure and re-determining the ionization potential (IP). By tuning one dye laser to a resonance and scanning the second laser such that the total energy was equal to or above the IP, over 150 autoionization states were determined. The IP was re-determined to be 6.211±.002 eV (50900 ± 20 cm-1). In addition, the typical cross section for ionization of an autoionizing state was determined to be 1 x 10-15 cm2

  10. Bone metastases as the presenting manifestation of rhabdomyosarcoma in childhood

    International Nuclear Information System (INIS)

    Rarely, rhabdomyosarcoma can present with bone pain and bone lesions on radiographs without evidence of a primary tumor. Of 428 children with biopsy-proven rhabdomyosarcoma, four presented with radiographic evidence of bone metastases, but no primary tumor was found on subsequent evaluation. On radiographs, these metastases, located most commonly in the metaphyses of the extremities and in the spine, displayed a destructive or diffusely permeative pattern without sclerotic margins and mimicked the more common neuroblastoma. One patient also had diaphyseal cortical lytic metastases of the tibia. Radiographs defined metastases of the extremities better than the correlative bone scans. In the spine, on T2-weighted magnetic resonance (MR) images, metastases displayed high signal intensity which contrasted with the low-signal-intensity marrow in these pediatric patients. On histopathologic examination, metastatic rhabdomyosarcoma was composed of small cells of variable size, shape, and growth pattern similar to other round cell tumors. A positive desmin immunohistochemical test helped to establish the diagnosis. The radiologist, pathologist, and clinician should be aware of this unusual presentation of rhabdomyosarcoma so that suitable immunohistochemical tests are performed and appropriate chemotherapy given. (orig.)

  11. Bone metastases as the presenting manifestation of rhabdomyosarcoma in childhood

    Energy Technology Data Exchange (ETDEWEB)

    Shapeero, L.G. (Dept. of Radiology, Inst. Gustave-Roussy, Villejuif (France) Dept. of Radiology, California Univ., San Francisco, CA (United States)); Couanet, D. (Dept. of Radiology, Inst. Gustave-Roussy, Villejuif (France)); Vanel, D. (Dept. of Radiology, Inst. Gustave-Roussy, Villejuif (France)); Ackerman, L.V. (Dept. of Pathology, State Univ., Stony Brook, NY (United States)); Terrier-Lacombe, M.J. (Dept. of Pathology, Inst. Gustave-Roussy, Villejuif (France)); Flamant, F. (Dept. of Pediatrics, Inst. Gustave-Roussy, Villejuif (France)); Contesso, G. (Dept. of Pathology, Inst. Gustave-Roussy, Villejuif (France)); Lumbroso, J. (Dept. of Nuclear Medicine, Inst. Gustave-Roussy, Villejuif (France))

    1993-08-01

    Rarely, rhabdomyosarcoma can present with bone pain and bone lesions on radiographs without evidence of a primary tumor. Of 428 children with biopsy-proven rhabdomyosarcoma, four presented with radiographic evidence of bone metastases, but no primary tumor was found on subsequent evaluation. On radiographs, these metastases, located most commonly in the metaphyses of the extremities and in the spine, displayed a destructive or diffusely permeative pattern without sclerotic margins and mimicked the more common neuroblastoma. One patient also had diaphyseal cortical lytic metastases of the tibia. Radiographs defined metastases of the extremities better than the correlative bone scans. In the spine, on T2-weighted magnetic resonance (MR) images, metastases displayed high signal intensity which contrasted with the low-signal-intensity marrow in these pediatric patients. On histopathologic examination, metastatic rhabdomyosarcoma was composed of small cells of variable size, shape, and growth pattern similar to other round cell tumors. A positive desmin immunohistochemical test helped to establish the diagnosis. The radiologist, pathologist, and clinician should be aware of this unusual presentation of rhabdomyosarcoma so that suitable immunohistochemical tests are performed and appropriate chemotherapy given. (orig.)

  12. Magnetic-Field Amplification in the Thin X-ray Rims of SN1006

    OpenAIRE

    Ressler, Sean M.; Katsuda, Satoru; Reynolds, Stephen P.; Knox S. Long; Petre, Robert; Williams, Brian J.; Winkler, P. Frank

    2014-01-01

    Several young supernova remnants (SNRs), including SN1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50 to 100 $\\mu$G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic-field damping could also produce thin rims. Here we review the literature o...

  13. Near-IR Imaging Polarimetry toward a Bright-Rimmed Cloud: Magnetic Field in SFO 74

    OpenAIRE

    Kusune, Takayoshi; Sugitani, Koji; Miao, Jingqi; Tamura, Motohide; Sato, Yaeko; Kwon, Jungmi; Watanabe,Makoto; Nishiyama, Shogo; Nagayama, Takahiro; Sato, Shuji

    2014-01-01

    We have made near-infrared (JHKs) imaging polarimetry of a bright-rimmed cloud (SFO 74). The polarization vector maps clearly show that the magnetic field in the layer just behind the bright rim is running along the rim, quite different from its ambient magnetic field. The direction of the magnetic field just behind the tip rim is almost perpendicular to that of the incident UV radiation, and the magnetic field configuration appears to be symmetric as a whole with respect to...

  14. Physiographic rim of the Grand Canyon, Arizona: a digital database

    Science.gov (United States)

    Billingsley, George H.; Hampton, Haydee M.

    1999-01-01

    This Open-File report is a digital physiographic map database. This pamphlet serves to introduce and describe the digital data. There is no paper map included in the Open-File report. The report does include, however, PostScript and PDF format plot files, each containing an image of the map. For those interested in a paper plot of information contained in the database or in obtaining the PostScript plot files, please see the section entitled "For Those Who Don't Use Digital Geologic Map Databases" below. This physiographic map of the Grand Canyon is modified from previous versions by Billingsley and Hendricks (1989), and Billingsley and others (1997). The boundary is drawn approximately along the topographic rim of the Grand Canyon and its tributary canyons between Lees Ferry and Lake Mead (shown in red). Several isolated small mesas, buttes, and plateaus are within this area, which overall encompasses about 2,600 square miles. The Grand Canyon lies within the southwestern part of the Colorado Plateaus of northern Arizona between Lees Ferry, Colorado River Mile 0, and Lake Mead, Colorado River Mile 277. The Colorado River is the corridor for raft trips through the Grand Canyon. Limestone rocks of the Kaibab Formation form most of the north and south rims of the Grand Canyon, and a few volcanic rocks form the north rim of parts of the Uinkaret and Shivwits Plateaus. Limestones of the Redwall Limestone and lower Supai Group form the rim of the Hualapai Plateau area, and Limestones of Devonian and Cambrian age form the boundary rim near the mouth of Grand Canyon at the Lake Mead. The natural physiographic boundary of the Grand Canyon is roughly the area a visitor would first view any part of the Grand Canyon and its tributaries.

  15. Energy Dependence of Synchrotron X-Ray Rims in Tycho's Supernova Remnant

    Science.gov (United States)

    Tran, Aaron; Williams, Brian J.; Petre, Robert; Ressler, Sean M.; Reynolds, Stephen P.

    2015-10-01

    Several young supernova remnants (SNRs) exhibit thin X-ray bright rims of synchrotron radiation at their forward shocks. Thin rims require strong magnetic field amplification beyond simple shock compression if rim widths are only limited by electron energy losses. But, magnetic field damping behind the shock could produce similarly thin rims with less extreme field amplification. Variation of rim width with energy may thus discriminate between competing influences on rim widths. We measured rim widths around Tycho's SNR in five energy bands using an archival 750 ks Chandra observation. Rims narrow with increasing energy and are well described by either loss-limited or damped scenarios, so X-ray rim width-energy dependence does not uniquely specify a model. But, radio counterparts to thin rims are not loss-limited and better reflect magnetic field structure. Joint radio and X-ray modeling favors magnetic damping in Tycho's SNR with damping lengths ˜1%-5% of remnant radius and magnetic field strengths ˜50-400 ?G assuming Bohm diffusion. X-ray rim widths are ˜1% of remnant radius, somewhat smaller than inferred damping lengths. Electron energy losses are important in all models of X-ray rims, suggesting that the distinction between loss-limited and damped models is blurred in soft X-rays. All loss-limited and damping models require magnetic fields ?20 ?G, affirming the necessity of magnetic field amplification beyond simple compression.

  16. Comperative study on four different radiographic technics to image the navicular bone

    International Nuclear Information System (INIS)

    In this paper the conventional x-ray technique according to Oxspring is compared with tomography and digitalized picture techniques (digital luminescent radiography, computed tomography, nuclear magnetic resonance tomography) to establish whether an improved picture of the equine navicular bone is possible. Because of a lack of detail, nuclear magnetic resonance tomography and digital luminescent radiography show no advantage. With tomography good picture of the navicular bone as well as the sesamoidian canals is gained, but the bone structure is not sharply visible. In spite of small losses in picture resolution, the computed tomography gives a picture with good contour and bone structure as well as an excellent differentiation between the density of spongiotic and sclerotic bone. When considering the picture quality (contour and structure of the navicular bone as well as number, shape, depth and surroundings of the sesamoidian canals), costs and technical possibilities of the examination procedures, the x-ray technique according to Oxspring still remains the method of choice in examining the equine navicular bone

  17. Radiological features of long bones in synovitis, acne, pustulosis, hyperostosis, osteitis syndrome and their correlation with pathological findings.

    Science.gov (United States)

    Orui, H; Takahara, M; Ishikawa, A; Takagi, M; Tsuchiya, T; Ogino, T

    2002-03-01

    Abstract The purpose of this study was to demonstrate the radiological features of long bones in synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome and to correlate these with the clinical findings. Eleven long bone lesions in seven cases of SAPHO syndrome were examined. The patients ranged in age from 6 to 63 years, with a mean of 47 years. In all seven cases, radiography, (99m)technetium bone scintigraphy, CT scan, and magnetic resonance imaging (MRI) were performed. In six of the cases, bone biopsy and bone culture were carried out for 7 long bones. Seven of the involved lesions were from the shaft of the femur, one each was from the neck and the shaft of the humerus, and one was from the proximal tibia. These lesions showed radiologically hyperostosis, osteolysis, and bone infarction-like lesion. Osteolysis was occasionally accompanied by sclerotic change. Hyperostosis usually showed diaphyseal involvement, presenting low signal intensity on T1- and T2-weighted MR images. Histologically, these findings corresponded to massive bone necrosis, new bone formation, fibrosis, or a mixture of these associated with mild inflammatory cell infiltration. Osteolysis involved dyaphysis, metaphysis, or epiphysis associated with arthritis, and presented low signal intensity on T1-weighted images, nonhomogeneous signal intensity lower than fat on T2-weighted images, and high signal intensity on fat suppression images. These findings corresponded to fibrosis, granulation, and inflammatory cell infiltration with lymphocyte aggregation. Bone infarction-like lesion was observed in the shaft or neck of the femur and the humerus and accompanied by calcification and cystic change. Bone cultures were negative in all cases in which bone biopsy was performed. Although hyperostosis is thought to be a characteristic bone lesion in SAPHO syndrome, the long bone lesion can occasionally show not only hyperostosis but also osteolytsis and bone infarction-like lesions. PMID:24383833

  18. 99mTc MDP bone scan in evaluation of painful scoliosis

    International Nuclear Information System (INIS)

    A 18-year-old male presented with low back ache. The patient was investigated and was diagnosed to have painful scoliosis. X-ray and other examinations could not reveal any diagnosis. The patient was referred to undergo bone scan on clinical suspicion of osteoid osteoma and to rule out stress fracture if any. Planar bone scan was performed, which showed a lesion in L3 vertebra and was further evaluated with SPECT (Single photon emission computed tomography) study to characterize the lesion. On SPECT examination, the classical features of osteoid osteoma, the double density sign (11), was noted in the pars interarticularis region. These findings were confirmed by a CT scan, which showed a sclerotic lesion in pars interarticularis of L3 vertebra. The patient was posted for operation and was relieved of symptoms in the postoperative follow-up. (author)

  19. PET/MR imaging of bone lesions - implications for PET quantification from imperfect attenuation correction

    Energy Technology Data Exchange (ETDEWEB)

    Samarin, Andrei [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); University Hospital Zurich, Nuclear Medicine, Zurich (Switzerland); Burger, Cyrill; Crook, David W.; Burger, Irene A.; Schmid, Daniel T.; Schulthess, Gustav K. von; Kuhn, Felix P. [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); Wollenweber, Scott D. [GE Healthcare, Waukesha, WI (United States)

    2012-07-15

    Accurate attenuation correction (AC) is essential for quantitative analysis of PET tracer distribution. In MR, the lack of cortical bone signal makes bone segmentation difficult and may require implementation of special sequences. The purpose of this study was to evaluate the need for accurate bone segmentation in MR-based AC for whole-body PET/MR imaging. In 22 patients undergoing sequential PET/CT and 3-T MR imaging, modified CT AC maps were produced by replacing pixels with values of >100 HU, representing mostly bone structures, by pixels with a constant value of 36 HU corresponding to soft tissue, thereby simulating current MR-derived AC maps. A total of 141 FDG-positive osseous lesions and 50 soft-tissue lesions adjacent to bones were evaluated. The mean standardized uptake value (SUVmean) was measured in each lesion in PET images reconstructed once using the standard AC maps and once using the modified AC maps. Subsequently, the errors in lesion tracer uptake for the modified PET images were calculated using the standard PET image as a reference. Substitution of bone by soft tissue values in AC maps resulted in an underestimation of tracer uptake in osseous and soft tissue lesions adjacent to bones of 11.2 {+-} 5.4 % (range 1.5-30.8 %) and 3.2 {+-} 1.7 % (range 0.2-4 %), respectively. Analysis of the spine and pelvic osseous lesions revealed a substantial dependence of the error on lesion composition. For predominantly sclerotic spine lesions, the mean underestimation was 15.9 {+-} 3.4 % (range 9.9-23.5 %) and for osteolytic spine lesions, 7.2 {+-} 1.7 % (range 4.9-9.3 %), respectively. CT data simulating treating bone as soft tissue as is currently done in MR maps for PET AC leads to a substantial underestimation of tracer uptake in bone lesions and depends on lesion composition, the largest error being seen in sclerotic lesions. Therefore, depiction of cortical bone and other calcified areas in MR AC maps is necessary for accurate quantification of tracer uptake values in PET/MR imaging. (orig.)

  20. 99mTc-MDP pinhole bone scintigraphic feature of fibrovascular zone: a new diagnostic sign of osteoid osteoma

    International Nuclear Information System (INIS)

    Osteoid osteoma is a common benign tumor. Histologically, the tumor is characterized by the presence of the nidus, fibrovascular zone (FVZ) and reactive host bone scleroses of various intensities. A nidus consists of core meshwork of osteoid trabeculae, woven bone and osteoblastic rim and a FVZ, 1-2 mm rim, is composed of loose fibrovascular tissue and nerve fibers. The nidus and FVZ are readily identifiable on pathological specimen and CT when sclerosis is not too extensive. Recently on pinhole bone scan, we observed a peculiar rim sign that denoted FVZ in a patient with pathologically proven osteoid osteoma. Not previously described the sign appears to be pathognomonic of osteoid osteoma, uniquely providing metabolic information. The finding was correlated with that of radiography, CT and MRI and low power light microscopy

  1. {sup 99m}Tc-MDP pinhole bone scintigraphic feature of fibrovascular zone: a new diagnostic sign of osteoid osteoma

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Yong Whee [Sung Ae Hospital, Seoul (Korea, Republic of); Kim, Sung Hoon; Choi, Yeong Jin [Catholic University Medical School, Seoul (Korea, Republic of)

    2007-02-15

    Osteoid osteoma is a common benign tumor. Histologically, the tumor is characterized by the presence of the nidus, fibrovascular zone (FVZ) and reactive host bone scleroses of various intensities. A nidus consists of core meshwork of osteoid trabeculae, woven bone and osteoblastic rim and a FVZ, 1-2 mm rim, is composed of loose fibrovascular tissue and nerve fibers. The nidus and FVZ are readily identifiable on pathological specimen and CT when sclerosis is not too extensive. Recently on pinhole bone scan, we observed a peculiar rim sign that denoted FVZ in a patient with pathologically proven osteoid osteoma. Not previously described the sign appears to be pathognomonic of osteoid osteoma, uniquely providing metabolic information. The finding was correlated with that of radiography, CT and MRI and low power light microscopy.

  2. Stability Analysis of Non-Newtonian Rimming Flow

    CERN Document Server

    Fomin, Sergei; Haine, Peter

    2015-01-01

    The rimming flow of a viscoelastic thin film inside a rotating horizontal cylinder is studied theoretically. Attention is given to the onset of non-Newtonian free-surface instability in creeping flow. This non-inertial instability has been observed in experiments, but current theoretical models of Newtonian fluids can neither describe its origin nor explain its onset. This study examines two models of non Newtonian fluids to see if the experimentally observed instability can be predicted analytically. The non-Newtonian viscosity and elastic properties of the fluid are described by the Generalized Newtonian Fluid (GNF) and Second Order Viscoelastic Fluid (SOVF) constitutive models, respectively. With linear stability analysis, it is found that, analogously to the Newtonian fluid, rimming flow of viscous non-Newtonian fluids (modeled by GNF) is neutrally stable. However, the viscoelastic properties of the fluid (modeled by SOVF) are found to contribute to the flow destabilization. The instability is shown to in...

  3. Selective Isotope Determination of Uranium using HR-RIMS

    International Nuclear Information System (INIS)

    The detection of lowest abundances of the ultra trace isotope 236U in environmental samples requires an efficient detection method which allows a high elemental and isotopic selectivity to suppress neighbouring isotopes of the same element and other background. High Resolution Laser Resonance Ionization Mass Spectrometry (HR-RIMS) uses the individual electron structure of each isotope to provide an outstanding element and isotope selective ionization.

  4. A SCUBA survey of bright-rimmed clouds

    OpenAIRE

    Morgan, L.K.; Thompson, M. A.; Urquhart, J. S.; White, G. J.

    2007-01-01

    Context. Bright-rimmed clouds (BRCs) are potential examples of triggered star formation regions, in which photoionisation driven shocks caused by the expansion of HII regions induce protostellar collapse within the clouds. Aims.The main purpose of the paper is to establish the level of star formation occuring within a known set of BRCs. A secondary aim is to determine the extent, if any, to which this star formation has been promulgated by the process of photoionisation triggering. ...

  5. Compactly supported solutions for a rimming flow model

    International Nuclear Information System (INIS)

    We study a generally ill-posed Cauchy problem with 2?-periodic initial data for a nonlinear forward–backward heat equation. The problem is originated from a lubrication approximation of viscous rimming flow dynamics on the inner surface of a rotating horizontal cylinder in the presence of gravitational field. For a certain class of compactly supported initial data we prove local in time existence of generalized weak solutions. (paper)

  6. Talking Bones.

    Science.gov (United States)

    Johnson, Jaclyn; Kassing, Sharon

    2002-01-01

    Describes cooperation with the Saint Louis Zoo to provide opportunities for elementary school students to learn about bones, how animals move, what they eat, and how much they grow. Uses biofacts which include bones, skulls, and other parts to make the laboratory a hands-on experience for students. (YDS)

  7. Hydrogeology associated to faulting of the Chicxulub Impact Crater rim

    Science.gov (United States)

    Rebolledo-Vieyra, M.; Hernandez-Terrones, L.; Almazan-Becerril, A.; Valadez-Cruz, F.

    2011-12-01

    The only surface expression of the Chicxulub Impact Crater is a Ring of Cenotes (sinkholes) whose density varies from several cenotes per kilometer, to several kilometers between each cenote. This ring has a radius of approximately 90 km and it is centered at Chicxulub Puerto. It is not known today whether the Ring of Cenotes is the surface expression of the transient cavity as some authors have suggested, or whether it is the outer rim of the impact structure. The center of the ring is approximately coincident with the center of the Chicxulub Impact Crater. Reactivation of K/T rim faults had been associated to the formation of the ring of cenotes. However, none of these models project such faults to the Tertiary sedimentary sequence; therefore we can only infer that the cenotes are associated to these faults. Other hypotheses include "post impact subsidence induced by slumping and viscous relaxation in the rim" and "slumping in the rim of the buried crater, differential thickness in the rocks overlying the crater, or solution collapse within porous impact deposits", others suggest duration of subaerial exposure and weathering as a principal reason both for difference in permeability and cenote density inside and outside the Ring. This is consistent with the evolution of surface features reported. While sedimentation occurred in the basin outlined by the Ring, erosion and karst weathering were taking place outside the Ring. The karst features are associated with gravity gradients, which have been interpreted as corresponding to peripheral faults of the buried crater. We conducted geoelectric tomography perpendicular to the ring of cenotes, where we mapped the karstic features in the area and we interpret the high permeability in this area, to be associated to the faults generated by the differential compaction of the sedimentary sequence within the crater. This fault system generates a secondary porosity with high permeability that allows the circulation of water, which, in turn, will dissolve the carbonates of the roof and hanging walls of the faults. Another group of cenotes, that is not related to the ring of cenotes, is the alignment of >100 km long chains of elongated solution depressions locally known as sabanas along the Holbox fracture zone-Xel-Ha zone; these alignments support the hypothesis of generation of karst features associated to weakness zones in major fractures zones, such as Holbox fracture zone-Xel-Ha zone and the Chicxulub crater rim.

  8. Crack revision improves fixation of uncemented HA-coated implants compared with reaming: an experiment in dogs

    DEFF Research Database (Denmark)

    Baas, Jørgen; Elmengaard, Brian; Jakobsen, Thomas; Bechtold, Joan E.; Søballe, Kjeld

    2009-01-01

    The crack procedure is a surgical technique for preparing the implant cavity at revision of loose joint replacement components. It disrupts the neocortical bone shell that typically forms around the cavity. Using an animal model, we compared the crack technique with reaming. Twenty micromotion implants were inserted bilaterally into the knees of 10 dogs according to our revision protocol, allowing formation of a standardized revision cavity (loose implant, fibrous tissue, and sclerotic bone rim)...

  9. Bone Graft Alternatives

    Science.gov (United States)

    ... graft that comes from a donor is called allograft bone . Allograft bone usually comes from bone banks that harvest the bone from cadavers. The types of allograft bone used for spine surgery include fresh frozen and ...

  10. Energy Dependence of Synchrotron X-Ray Rims in Tycho's Supernova Remnant

    CERN Document Server

    Tran, Aaron; Petre, Robert; Ressler, Sean M; Reynolds, Stephen P

    2015-01-01

    Several young supernova remnants exhibit thin X-ray bright rims of synchrotron radiation at their forward shocks. Thin rims require strong magnetic field amplification beyond simple shock compression if rim widths are only limited by electron energy losses. But, magnetic field damping behind the shock could produce similarly thin rims with less extreme field amplification. Variation of rim width with energy may thus discriminate between competing influences on rim widths. We measured rim widths around Tycho's supernova remnant in 5 energy bands using an archival 750 ks Chandra observation. Rims narrow with increasing energy and are well described by either loss-limited or damped scenarios, so X-ray rim width-energy dependence does not uniquely specify a model. But, radio counterparts to thin rims are not loss-limited and better reflect magnetic field structure. Joint radio and X-ray modeling favors magnetic damping in Tycho's SNR with damping lengths ~1--5% of remnant radius and magnetic field strengths ~50--...

  11. NEAR-IR IMAGING POLARIMETRY TOWARD A BRIGHT-RIMMED CLOUD: MAGNETIC FIELD IN SFO 74

    Energy Technology Data Exchange (ETDEWEB)

    Kusune, Takayoshi; Sugitani, Koji [Graduate School of Natural Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-8501 (Japan); Miao, Jingqi [Centre for Astrophysics and Planetary Science, School of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NR (United Kingdom); Tamura, Motohide; Kwon, Jungmi [Department of Astronomy, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Sato, Yaeko [National Astronomical Observatory, 2-21-1 Osawa, Mikata, Tokyo 181-8588 (Japan); Watanabe, Makoto [Department of Cosmosciences, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0810 (Japan); Nishiyama, Shogo [Faculty of Education, Miyagi University of Education, Sendai 980-0845 (Japan); Nagayama, Takahiro [Department of Physics, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065 (Japan); Sato, Shuji [Department of Astrophysics, Nagoya University, Chikusa-ku, Nagoya 464-8602 (Japan)

    2015-01-01

    We have made near-infrared (JHK {sub s}) imaging polarimetry of a bright-rimmed cloud (SFO 74). The polarization vector maps clearly show that the magnetic field in the layer just behind the bright rim is running along the rim, quite different from its ambient magnetic field. The direction of the magnetic field just behind the tip rim is almost perpendicular to that of the incident UV radiation, and the magnetic field configuration appears to be symmetric as a whole with respect to the cloud symmetry axis. We estimated the column and number densities in the two regions (just inside and far inside the tip rim) and then derived the magnetic field strength, applying the Chandrasekhar-Fermi method. The estimated magnetic field strength just inside the tip rim, ?90 ?G, is stronger than that far inside, ?30 ?G. This suggests that the magnetic field strength just inside the tip rim is enhanced by the UV-radiation-induced shock. The shock increases the density within the top layer around the tip and thus increases the strength of the magnetic field. The magnetic pressure seems to be comparable to the turbulent one just inside the tip rim, implying a significant contribution of the magnetic field to the total internal pressure. The mass-to-flux ratio was estimated to be close to the critical value just inside the tip rim. We speculate that the flat-topped bright rim of SFO 74 could be formed by the magnetic field effect.

  12. NEAR-IR IMAGING POLARIMETRY TOWARD A BRIGHT-RIMMED CLOUD: MAGNETIC FIELD IN SFO 74

    International Nuclear Information System (INIS)

    We have made near-infrared (JHK s) imaging polarimetry of a bright-rimmed cloud (SFO 74). The polarization vector maps clearly show that the magnetic field in the layer just behind the bright rim is running along the rim, quite different from its ambient magnetic field. The direction of the magnetic field just behind the tip rim is almost perpendicular to that of the incident UV radiation, and the magnetic field configuration appears to be symmetric as a whole with respect to the cloud symmetry axis. We estimated the column and number densities in the two regions (just inside and far inside the tip rim) and then derived the magnetic field strength, applying the Chandrasekhar-Fermi method. The estimated magnetic field strength just inside the tip rim, ?90 ?G, is stronger than that far inside, ?30 ?G. This suggests that the magnetic field strength just inside the tip rim is enhanced by the UV-radiation-induced shock. The shock increases the density within the top layer around the tip and thus increases the strength of the magnetic field. The magnetic pressure seems to be comparable to the turbulent one just inside the tip rim, implying a significant contribution of the magnetic field to the total internal pressure. The mass-to-flux ratio was estimated to be close to the critical value just inside the tip rim. We speculate that the flat-topped bright rim of SFO 74 could be formed by the magnetic field effect

  13. A simplified procedure for preparation of undecalcified human bone sections

    DEFF Research Database (Denmark)

    Wallin, J A; Tkocz, I; Levinsen, J

    1985-01-01

    A new type of apparatus for sectioning samples of hard, undecalcified bone is described. Slices of fresh or archeological human bone 4-5 mm thick are dehydrated and then embedded in epoxy resin. The apparatus used to prepare sections from the resulting blocks consists of a low-speed rim-type diamond cut-off wheel and a slowly advancing table carrying the specimen held in a rotating mount. Sections may be cut at a thickness of 80 micron +/- 1%. After cleaning in an ultrasonic bath, these can be m...

  14. A simplified procedure for preparation of undecalcified human bone sections

    DEFF Research Database (Denmark)

    Wallin, J A; Tkocz, I

    1985-01-01

    A new type of apparatus for sectioning samples of hard, undecalcified bone is described. Slices of fresh or archeological human bone 4-5 mm thick are dehydrated and then embedded in epoxy resin. The apparatus used to prepare sections from the resulting blocks consists of a low-speed rim-type diamond cut-off wheel and a slowly advancing table carrying the specimen held in a rotating mount. Sections may be cut at a thickness of 80 micron +/- 1%. After cleaning in an ultrasonic bath, these can be mounted on slides for quantitative microscopic examination with transmitted light. Grinding and polishing are not necessary. The results obtained are illustrated.

  15. The importance of rim removal in deep lateral orbital wall decompression

    Directory of Open Access Journals (Sweden)

    Kakizaki H

    2011-06-01

    Full Text Available Hirohiko Kakizaki1, Yasuhiro Takahashi1, Akihiro Ichinose2, Masayoshi Iwaki1, Dinesh Selva3, Igal Leibovitch41Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi, Japan; 2Department of Plastic Surgery, Kobe University, Kobe, Hyogo, Japan; 3South Australian Institute of Ophthalmology and Discipline of Ophthalmology and Visual Sciences, University of Adelaide, South Australia, Australia; 4Division of Oculoplastic and Orbital Surgery, Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, IsraelPurpose: To evaluate the surgical outcome of deep lateral orbital decompression with or without rim removal.Design: Retrospective case series.Methods: Thirty-two patients (47 orbits with Graves’ orbitopathy who underwent simple deep lateral decompression or balanced lateral plus medial decompression. Of the 14 patients (24 orbits who underwent simple deep lateral decompression, 8 (13 orbits had temporary rim removal and in 6 (11 orbits the rim was left intact. Of the 18 patients (23 orbits who underwent a balanced decompression, 7 (9 orbits had temporary rim removal and in 11 (14 orbits the rim was left intact. The amount of postoperative reduction in proptosis was compared among these four groups.Results: The average reduction in proptosis in the simple deep lateral decompression group was 5.73 mm (range: 4.0–8.0 mm in the rim removal group and 4.09 mm (range: 2.5–6.0 mm in the intact rim group (P = 0.005. The average reduction in proptosis in the balanced decompression group was 6.39 mm (range: 5.0–8.5 mm in the rim removal group and 5.07 mm (range: 3.0–8.0 mm in the intact rim group (P = 0.039. There was no statistically significant difference in proptosis reduction between the simple deep lateral decompression with rim removal group and the balanced decompression with an intact rim group (P = 0.220.Conclusion: The rim removal approach allows a more effective decompression than the intact rim approach. Simple deep lateral decompression with rim removal approach has a similar effect to balanced decompression through an intact rim.Keywords: deep lateral decompression, balanced decompression, rim removal, intact rim, Graves’ orbitopathy, proptosis

  16. Investigation about crack propagation paths in thin rim gears

    Directory of Open Access Journals (Sweden)

    F. Curà

    2014-10-01

    Full Text Available Crack propagation in gears is a problem related not only to the life of the components, but also to the concept of failsafe design. Fail safe design means to design a component in order that, if a failure occurs, this may cause a “safe failure”. This aspect is very important above all in aerospace industry. As a matter of fact, in aerospace application, the need of reducing weight brings to produce gears with very thick rim and web. Considering thin rim gears, when a crack is nucleated near the tooth root, it may propagate through the tooth (causing the loss of the entire tooth or a portion of it or the propagation may follow a path across the wheel diameter (causing the projection of big parts of the gear that may break the gearbox and may cause serious damage to the aircraft. The first failure mode is define as “failsafe failure” and the second one as “catastrophic failure” and of course has to be avoided. Designers need to have robust design criteria in order to predict crack propagation paths and to avoid catastrophic failures. In literature, few works are present concerning this topic, in particular related to the effect of geometrical parameters that may affect the crack propagation. In this work a numerical analysis about crack propagation in gears with respect to the backup ratio (ratio between tooth height and rim thickness, initial crack position and shape has been done by means of the Extended FEM (XFEM technique, realizing 3D models. XFEM 3D is a relatively new technique consisting in enriching traditional finite elements with more complex shape functions; in this way it is possible to propagate crack also between mesh nodes and to have mesh independent results. Aim of this paper is to highlight the crack propagation path in order to give to designers an high confident design criterion, related to the gear geometry. In particular, the effect of both rim thickness and orientation of the initial crack have been considered in order to enrich the literature knowledge. Numerical results obtained in this work have been compared with those found in the literature, showing a very good correlation.

  17. Archaeological sites on the Indian Ocean Rim - A growing database

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.

    Archaeological Sites on the Indian Ocean Rim I A GROWING DATABASE~ This section IS designed to act as a plafform for reporting explored and excavated sites of all penods located along the Indian Ocean nm The Indian Ocean IS broadly defined It Includes the Red Sea... of the Indian Ocean at the beginning of the sedan All references are given In full at the end of the section GUidelines for prepanng the database In the prescnbed format IS given In thiS sedan 1. Miyani 3. Udyavara 2. Kuda 4. Karaikadu ~.. I no' @mol)$,corn o...

  18. RIMS diagnostics for laser desorption/laser ablation

    Energy Technology Data Exchange (ETDEWEB)

    Apel, E.C.; Nogar, N.S.; Miller, C.M.; Estler, R.C.

    1986-01-01

    Laser desorption mass spectrometry is a useful method for interrogating materials and events at or near surfaces. Laser desorption/ablation combined with Resonance Ionization Mass Spectrometry (RIMS) provides a powerful tool to obtain information on chemical composition and speciation and, in some cases, internal and translational energy distributions. The application of this technique to the interrogation of materials and interfaces is discussed for several systems, including the analysis of conventional analytical samples, and the study of optical damage events. 8 refs., 2 figs., 1 tab.

  19. Evolution of the east rim of the Hellas basin, Mars

    Science.gov (United States)

    Crown, David A.; Price, Katherine H.; Greeley, Ronald

    1991-01-01

    The Hellas basin is a dominant feature in the ancient, southern cratered highlands of Mars. The east rim of Hellas is a complex geologic region affected by volcanism, tectonism, and channeling. A detailed study of the area between 27.5-42.4 degrees S and 260-275 degrees W was initiated to analyze the processes forming surface materials and to decipher the evolution of this geologically important highland area. Major units include Hadriaca and Tyrrhena Paterae in the north and Hesperian and Amazonian channeled plains and outflow channels in the south. A brief discussion of the findings is presented.

  20. Triggered Star Formation in the Orion Bright-Rimmed Clouds

    OpenAIRE

    Lee, Hsu-Tai; Chen, W. P.; Zhang, Zhi-Wei; Hu, Jing-Yao

    2005-01-01

    We have developed an empirical and effective set of criteria, based on the 2MASS colors, to select candidate classical T Tauri stars (CTTS). This provides a useful tool to study the young stellar population in star-forming regions. Here we present our analysis of the bright-rimmed clouds (BRCs) B 35, B 30, IC 2118, LDN 1616, LDN 1634, and Orion East to show how massive stars interact with molecular clouds to trigger star formation. Our results support the radiation-driven im...

  1. Bone Markers

    Science.gov (United States)

    ... Osteoporosis Foundation (IOF) and the International Federation for Clinical Chemistry (IFCC) recommend two blood tests for evaluating bone ... For Health Professionals ©2001 - by American Association for Clinical Chemistry • Contact Us | Terms of Use | Privacy We comply ...

  2. Broken bone

    Science.gov (United States)

    The following are common causes of broken bones: Fall from a height Motor vehicle accidents Direct blow Child abuse Repetitive forces, such as those caused by running, can cause stress fractures of the foot, ankle, tibia, or hip

  3. RIM, Munc13, and Rab3A interplay in acrosomal exocytosis

    International Nuclear Information System (INIS)

    Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: ? RIM and Munc13 are present in human sperm and localize to the acrosomal region. ? RIM and Munc13 are necessary for acrosomal exocytosis. ? RIM and Munc13 participate before the acrosomal calcium efflux. ? RIM, Munc13 and Rab3A interplay in human sperm acrosomal exocytosis. ? RIM and Rab3A have critical roles in membrane docking.

  4. Rimmed Vacuoles in Becker Muscular Dystrophy Have Similar Features with Inclusion Myopathies

    OpenAIRE

    Momma, Kazunari; Noguchi, Satoru; Malicdan, May Christine V.; Hayashi, Yukiko K; Minami, Narihiro; Kamakura, Keiko; NONAKA, Ikuya; NISHINO, Ichizo

    2012-01-01

    Rimmed vacuoles in myofibers are thought to be due to the accumulation of autophagic vacuoles, and can be characteristic in certain myopathies with protein inclusions in myofibers. In this study, we performed a detailed clinical, molecular, and pathological characterization of Becker muscular dystrophy patients who have rimmed vacuoles in muscles. Among 65 Becker muscular dystrophy patients, we identified 12 patients who have rimmed vacuoles and 11 patients who have deletions in exons 45–48 i...

  5. Eastern rim of the Chesapeake Bay impact crater: Morphology, stratigraphy, and structure

    Science.gov (United States)

    Poag, C.W.

    2005-01-01

    This study reexamines seven reprocessed (increased vertical exaggeration) seismic reflection profiles that cross the eastern rim of the Chesapeake Bay impact crater. The eastern rim is expressed as an arcuate ridge that borders the crater in a fashion typical of the "raised" rim documented in many well preserved complex impact craters. The inner boundary of the eastern rim (rim wall) is formed by a series of raterfacing, steep scarps, 15-60 m high. In combination, these rim-wall scarps represent the footwalls of a system of crater-encircling normal faults, which are downthrown toward the crater. Outboard of the rim wall are several additional normal-fault blocks, whose bounding faults trend approximately parallel to the rim wall. The tops of the outboard fault blocks form two distinct, parallel, flat or gently sloping, terraces. The innermost terrace (Terrace 1) can be identified on each profile, but Terrace 2 is only sporadically present. The terraced fault blocks are composed mainly of nonmarine, poorly to moderately consolidated, siliciclastic sediments, belonging to the Lower Cretaceous Potomac Formation. Though the ridge-forming geometry of the eastern rim gives the appearance of a raised compressional feature, no compelling evidence of compressive forces is evident in the profiles studied. The structural mode, instead, is that of extension, with the clear dominance of normal faulting as the extensional mechanism. ?? 2005 Geological Society of America.

  6. 68Ga-DOTA-NOC PET/CT in comparison with CT for the detection of bone metastasis in patients with neuroendocrine tumours

    International Nuclear Information System (INIS)

    To retrospectively evaluate the sensitivity, specificity and accuracy of 68Ga-DOTA-NOC PET/CT and CT alone for the evaluation of bone metastasis in patients with neuroendocrine tumour (NET). From among patients with NET who underwent 68Ga-DOTA-NOC PET/CT between April 2006 and November 2008 in our centre, 223 were included in the study. Criteria for inclusion were pathological confirmation of NET and a follow-up period of at least 10 months. PET and CT images were retrospectively reviewed by two nuclear medicine specialists and two radiologists, respectively, without knowledge of the patient history or the findings of other imaging modalities. PET data were compared with the CT findings. Interobserver agreement was evaluated in terms of the kappa score. Clinical and imaging follow-up were used as the standard of reference to evaluate the PET findings. PET was performed for staging (49/223), unknown primary tumour detection (24/223), restaging (32/223), restaging before radioimmunotherapy (1/223), evaluation during therapy (12/223), equivocal findings on conventional imaging (4/223 at the bone level; 61/223 at sites other than bone), and follow-up (40/223). A very high interobserver agreement was observed. CT detected at least one bone lesion in only 35 of 44 patients with a positive PET scan. In particular, PET showed more lesions in 20/35 patients, a lower number of lesions in 8/35, and the same number in 7/35. The characteristics of the lesions (sclerotic, lytic, mixed) on the basis of the CT report did not influence PET reading. PET revealed the presence of at least one bone metastasis in nine patients with a negative CT scan. Considering patients with a negative PET scan (179), CT showed equivocal findings at the bone level in three (single small sclerotic abnormality in two at the spine level, and bilateral small sclerotic abnormalities in the humeri, femurs and scapula). Clinical follow-up confirmed the PET findings in all patients; thus there were no false-positive or false-negative findings. Considering all patients, PET detected more lesions than CT (246 vs. 194). As compared to CT, on a patient basis PET showed a higher sensitivity (100% vs. 80%), specificity (100% vs. 98%), positive predictive value (100% vs. 92%), and negative predictive value (100% vs. 95%). In conclusion, 68Ga DOTA-NOC PET was more accurate than CT for the identification of bone lesions and led to a change in clinical management in nine patients with a negative CT scan. (orig.)

  7. Disorders of Bone Remodeling

    OpenAIRE

    Feng, Xu; McDonald, Jay M.

    2011-01-01

    The skeleton provides mechanical support for stature and locomotion, protects vital organs, and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone modeling to carry out these crucial functions throughout life. Bone remodeling involves the removal of old or damaged bone by osteoclasts (bone resorption) and the subsequent replacement of new bone formed by osteoblasts (bone formation). Normal bone remodeling requires a tight coupling of bone resorption to bone f...

  8. Dark-rimmed Crater and Extensive Ejecta Blanket

    Science.gov (United States)

    1974-01-01

    Mariner 10 took this picture (FDS 166840) from a distance of 63,400 kilometers (39,300 miles) about an hour after it passed under the South Pole of Mercury. The dark-rimmed crater at upper left is 67 kilometers (42 miles) in diameter. It is surrounded by an extensive ejecta blanket and exhibits a bright ray pattern, which extends into and beyond the larger crater (120 kilometers, 75 miles) to its right and near the picture's center. The dark-rimmed crater is similar to crater Tycho on Earth's moon. The center of this picture is located 33 degrees S. Lat. 158 degrees W. Long. North is to the top.The Mariner 10 mission, managed by the Jet Propulsion Laboratory for NASA's Office of Space Science, explored Venus in February 1974 on the way to three encounters with Mercury-in March and September 1974 and in March 1975. The spacecraft took more than 7,000 photos of Mercury, Venus, the Earth and the Moon.Image Credit: NASA/JPL/Northwestern University

  9. Optimization of Hydride Rim Formation in Unirradiated Zr 4 Cladding

    Energy Technology Data Exchange (ETDEWEB)

    Shimskey, Rick W.; Hanson, Brady D.; MacFarlan, Paul J.

    2013-09-30

    The purpose of this work is to build on the results reported in the M2 milestone M2FT 13PN0805051, document number FCRD-USED-2013-000151 (Hanson, 2013). In that work, it was demonstrated that unirradiated samples of zircaloy-4 cladding could be pre-hydrided at temperatures below 400°C in pure hydrogen gas and that the growth of hydrides on the surface could be controlled by changing the surface condition of the samples and form a desired hydride rim on the outside diameter of the cladding. The work performed at Pacific Northwest National Laboratory since the issuing of the M2 milestone has focused its efforts to optimize the formation of a hydride rim on available zircaloy-4 cladding samples by controlling temperature variation and gas flow control during pre-hydriding treatments. Surface conditioning of the outside surface was also examined as a variable. The results of test indicate that much of the variability in the hydride thickness is due to temperature variation occurring in the furnaces as well as how hydrogen gas flows across the sample surface. Efforts to examine other alloys, gas concentrations, and different surface conditioning plan to be pursed in the next FY as more cladding samples become available

  10. Influence of deformation on dolomite rim growth kinetics

    Science.gov (United States)

    Helpa, Vanessa; Rybacki, Erik; Grafulha Morales, Luiz Fernando; Dresen, Georg

    2015-04-01

    Using a gas-deformation apparatus stacks of oriented calcite (CaCO3) and magnesite (MgCO3) single crystals were deformed at T = 750° C and P = 400 MPa to examine the influence of stress and strain on magnesio-calcite and dolomite (CaMg[CO3]2) growth kinetics. Triaxial compression and torsion tests performed at constant stresses between 7 and 38 MPa and test durations between 4 and 171 hours resulted in bulk strains of 0.03-0.2 and maximum shear strains of 0.8-5.6, respectively. The reaction rims consist of fine-grained (2-7 ?m) dolomite with palisade-shaped grains growing into magnesite reactants and equiaxed granular dolomite grains next to calcite. In between dolomite and pure calcite, magnesio-calcite grains evolved with an average grain size of 20-40 ?m. Grain boundaries tend to be straighter at high bulk strains and equilibrium angles at grain triple junctions are common within the magnesio-calcite layer. Transmission electron microscopy shows almost dislocation free palisades and increasing dislocation density within granular dolomite towards the magnesio-calcite boundary. Within magnesio-calcite grains, dislocations are concentrated at grain boundaries. Variation of time at fixed stress (˜17 MPa) yields a parabolic time dependence of dolomite rim width, indicating diffusion-controlled growth, similar to isostatic rim growth behavior. In contrast, the magnesio-calcite layer growth is enhanced compared to isostatic conditions. Triaxial compression at given time shows no significant change of dolomite rim thickness (11±2 ?m) and width of magnesio-calcite layers (33±5 ?m) with increasing stress. In torsion experiments, reaction layer thickness and grain size decrease from the center (low stress/strain) to the edge (high strain/stress) of samples. Chemical analysis shows nearly stoichiometric composition of dolomite palisades, but enhanced Ca content within granular grains, indicating local disequilibrium with magnesio-calcite, in particular for twisted samples. The shift from local equilibrium is ˜3 mol% in triaxial compression and ˜7 mol% in torsion. Electron backscatter diffraction analysis reveals a crystallographic preferred orientation (CPO) within the reaction layers with [0001] axes parallel to the compression/rotation axis and poles of {2-1-10} and {10-10} prismatic planes parallel to the reaction interface. Compared to isostatic annealing, the CPO is more pronounced and the amount of low-angle grain boundaries is increased. At the imposed experimental conditions, most of the bulk deformation is accommodated by calcite single, which is stronger than magnesite. Application of flow laws for magnesio-calcite and dolomite suggest that the fine-grained reaction products should deform by grain boundary diffusion creep, resulting in lower flow strength than the single crystal reactants. However, microstructural observations indicate that deformation of granular dolomite and magnesio-calcite is at least partially assisted by dislocation creep, which would result in an almost similar strength to calcite. Therefore, flattening of the reaction layers during triaxial compression may be counterbalanced by enhanced reaction rates, resulting in almost constant layer thickness, independent of the applied stress. For simple shear, the reduced reaction kinetics in the high stress/strain region of twisted samples may be related to increased nucleation rates, resulting in a lower grain size and rim thickness.

  11. Calcium and bones

    Science.gov (United States)

    Bone strength and calcium ... calcium (as well as phosphorus) to make healthy bones. Bones are the main storage site of calcium in ... your body does not absorb enough calcium, your bones can get weak or will not grow properly. ...

  12. Bone lesion biopsy

    Science.gov (United States)

    Bone biopsy; Biopsy - bone ... needle is gently pushed and twisted into the bone. Once the sample is obtained, the needle is ... sample is sent to a lab for examination. Bone biopsy may also be done under general anesthesia ...

  13. Bone marrow aspiration

    Science.gov (United States)

    ... the hollow part of most bones. Bone marrow aspiration is the removal of a small amount of ... tissue in liquid form for examination. Bone marrow aspiration is not the same as bone marrow biopsy . ...

  14. NEW MOLECULES IN THE TUMOR NECROSIS FACTOR LIGAND AND RECEPTOR SUPERFAMILIES WITH IMPORTANCE FOR PHYSIOLOGICAL AND PATHOLOGICAL BONE RESORPTION.

    Science.gov (United States)

    Lerner, Ulf H.

    2004-01-01

    Osteoclasts are tissue-specific polykaryon bone-resorbing cells derived from the monocyte/macrophage hematopoietic lineage with specialized functions required for the adhesion of the cells to bone and the subsequent polarization of the cell membrane, secretion of acid to dissolve mineral crystals, and release of proteolytic enzymes to degrade the extracellular matrix proteins. Most pathological conditions in the skeleton lead to loss of bone due to excess osteoclastic bone resorption, including periodontal disease, rheumatoid arthritis, and osteoporosis. In rare cases, most of them genetic, patients with osteopetrosis exhibit sclerotic bone due either to a lack of osteoclasts or to non-functional osteoclasts. Mainly because of phenotypic findings in genetically manipulated mice or due to spontaneous mutations in humans, mice, and rats, several genes have been discovered as being crucial for osteoclast formation and activation. Recent breakthroughs in our understanding of osteoclast biology have revealed the critical roles in osteoclast differentiation played by RANKL, RANK, and OPG, three novel members of the tumor necrosis factor ligand and receptor superfamilies. The further study of these molecules and downstream signaling events are likely to provide a molecular basis for the development of new drugs for the treatment of diseases with excess or deficient osteoclastic bone resorption. PMID:15059943

  15. A magnetic resonance imaging study on changes in rat mandibular bone marrow and pulp tissue after high-dose irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Wan; Lee, Byung Do [Dept. of Oral and Maxillofacial Radiology and Wonkwang Dental Research Institute, College of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Lee, Kang Kyoo [Dept. of Radiation Oncology, School of Medicine, Wonkwang University, Iksan (Korea, Republic of); Koh, Kwang Joon [Dept. of Oral and Maxillofacial Radiology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju (Korea, Republic of)

    2014-03-15

    This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow.

  16. [Bone transplant].

    Science.gov (United States)

    San Julián, M; Valentí, A

    2006-01-01

    We describe the methodology of the Bone and Soft Tissue Bank, from extraction and storage until use. Since the year 1986, with the creation of the Bone Bank in the University Clinic of Navarra, more than 3,000 grafts have been used for very different types of surgery. Bone grafts can be classified into cortical and spongy; the former are principally used in surgery to save tumour patients, in large post-traumatic reconstructions and in replacement surgery where there are massive bone defects and a structural support is required. The spongy grafts are the most used due to their numerous indications; they are especially useful in filling cavities that require a significant quantity of graft when the autograft is insufficient, or as a complement. They are also of special help in treating fractures when there is bone loss and in the treatment of delays in consolidation and pseudoarthrosis in little vascularized and atrophic zones. They are also used in prosthetic surgery against the presence of cavity type defects. Allografts of soft tissues are specially recognised in multiple ligament injuries that require reconstructions. Nowadays, the most utilised are those employed in surgery of the anterior cruciate ligament although they can be used for filling any ligament or tendon defect. The principal difficulties of the cortical allografts are in the consolidation of the ends with the bone itself and in tumour surgery, given that these are patients immunodepressed by the treatment, the incidence of infection is increased with respect to spongy grafts and soft tissues, which is irrelevant. In short, the increasingly widespread use of allografts is an essential therapeutic weapon in orthopaedic surgery and traumatology. It must be used by expert hands. PMID:16998521

  17. From Theory to Practice: "Kaizen" and the Academy of the Pacific Rim

    Science.gov (United States)

    Blasdale, Spencer

    2004-01-01

    In this article, the author profiles the Academy of the Pacific Rim Charter Public School (Hyde Park, Massachusetts) and describes the school's culture. The school's students, who are in grades 6 through 12, are surrounded by rituals, routines, and relationship-building activities. Pacific Rim's culture stems from and supports the school's…

  18. Failure of a floating-rim generator rotor: Nipawin hydroelectric station

    Energy Technology Data Exchange (ETDEWEB)

    Callahan, G.E.

    1993-01-01

    This paper describes the problems experienced by SaskPower with the floating-rim design of the generator rotor as used on the three units at the Nipawin Hydroelectric Station. A brief description of the rebuild of the Unit 2 rotor is presented and the critical considerations of the floating-rim design of the rotor to ensure satisfactory service are examined.

  19. Structural outer rim of Chesapeake Bay impact crater: Seismic and bore hole evidence

    Science.gov (United States)

    Poag, C.W.

    1996-01-01

    Nine seismic-reflection profiles and four continuous core holes define the gross structural and stratigraphic framework of the outer rim of the Chesapeake Bay impact crater. The rim is manifested as a 90 km diameter ring of terraced normal-fault blocks, which forms a ???320 m-1200 m high rim escarpment. The top of the rim escarpment is covered by a 20 m-30 m thick ejecta blanket. The escarpment encircles a flat-floored annular trough, which is partly filled with an ???250 m thick breccia lens (Exmore breccia). The Exmore breccia overlies a 200 m-800 m thick interval of slumped sedimentary megablocks, which, in turn, rests on crystalline basement rocks. All postimpact strata (upper Eocene to Quaternary) sag structurally into the annular trough, and most units also thicken as they cross the rim into the crater. Postimpact compaction and subsidence of the Exmore breccia have created extensive normal faulting in overlying strata.

  20. Bone: From planar imaging to SPECT & PET/CT

    Directory of Open Access Journals (Sweden)

    Mihailovi? Jasna

    2012-01-01

    Full Text Available Since its introduction into clinical medicine 50 years ago, the radionuclide bone scan has played a key role in diagnosing a variety of osseous disorders; particularly metastatic disease. Using small diagnostic doses of Strontium-85 in the 1960’s, it was rapidly established that the study was much more sensitive than skeletal radiographs. The introduction of Technetium-99m phosphate agents in the early 1970’s, offered greatly improved resolution. Whole body imaging became the standard procedure. Interestingly, the positron-emitter, Fluorine 18-sodium fluoride was used by some investigators with the rectilinear scanner. Very recently, this radiotracer has been re-introduced and is witnessing considerable growth using modern PET/CT instrumentation. The cortical bone tracers, 99mTc-MDP and 18F-Fluoride assess osteoblastic response to the invading lesion. In the study of metastatic disease, it is superb for sclerotic blastic lesions. Although it detects most lytic lesions, many can be missed. This is due to a lack of osteoblastic response. The tumor may be slow growing, such as myeloma or conversely very rapidly growing and destructive, such as lung or kidney metastases. In these lesions, 18F-FDG is superior because it is concentrating in the tumor cells and does not depend on osteoblastic response to the tumor. In their early cause, many lytic lesions may be confined to the medullary portion of bone and not yet involve the cortex. Comparative studies of PET and CT have clearly shown the superior sensitivity of FDG in detecting metastatic bone lesions.

  1. Mass Movement on Vesta at Steep Scarps and Crater Rims

    Science.gov (United States)

    Krohn, K.; Jaumann, R.; Otto, K.; Hoogenboom, T.; Wagner, R.; Buczkowski, D. L.; Garry, B.; Williams, D. A.; Yingst, R. A.; Scully, J.; De Sanctis, M. C.; Kneissl, T.; Schmedemann, N.; Kersten, E.; Stephan, K.; Matz, K.-D.; Pieters, C. M.; Preusker, F.; Roatsch, T.; Schenk, P.; Russell, C. T.; Raymond, C. A.

    2014-01-01

    The Quadrangles Av-11 and Av-12 on Vesta are located at the northern rim of the giant Rheasilvia south polar impact basin. The primary geologic units in Av-11 and Av-12 include material from the Rheasilvia impact basin formation, smooth material and different types of impact crater structures (such as bimodal craters, dark and bright crater ray material and dark ejecta material). Av-11 and Av-12 exhibit almost the full range of mass wasting features observed on Vesta, such as slump blocks, spur-and-gully morphologies and landslides within craters. Processes of collapse, slope instability and seismically triggered events force material to slump down crater walls or scarps and produce landslides or rotational slump blocks. The spur-and-gully morphology that is known to form on Mars is also observed on Vesta; however, on Vesta this morphology formed under dry conditions.

  2. Windage rise and flowpath gas ingestion in turbine rim cavities

    Science.gov (United States)

    Haaser, Fred; Jack, James; McGreehan, William

    1987-05-01

    A method for modeling the windage rise and flowpath gas ingestion in turbine rim cavities on a macroscopic scale is presented, with application to the minimization of the necessary required cooling air in order to provide optimum turbine cycle performance and hardware durability. Comparison is made between measured and predicted results for: (1) the prediction of critical flow in a turbine aeroperformance rig; (2) a boltless blade retainer design; (3) the impact of instrumentation wire; and (4) a modulated throughflow test. It is noted that the effects of inner and outer flow extraction, rotor and stator drag, rotor and stator bolt drag, leakages, and injection momentum must be accounted for to accurately model the wheel space.

  3. [Sialic Acid Replacement Therapy for Distal Myopathy with Rimmed Vacuoles].

    Science.gov (United States)

    Mori-Yoshimura, Madoka; Nishino, Ichizo

    2015-09-01

    Distal myopathy with rimmed vacuoles or GNE myopathy, is an early adult-onset myopathy with slow progression that preferentially affects the tibialis anterior muscle. Severely affected patients show marked limb muscle atrophy together with respiratory dysfunction. The disease is caused by a mutation in the GNE gene that catalyzes two rate-limiting reactions in cytosolic sialic acid synthesis. Oral treatment with sialic acid metabolite prevents muscle atrophy and weakness in a mouse GNE myopathy model and a global Phase III study is currently underway. In addition, a global patient registry of neuromuscular cases is widely accepted as a useful tool to obtain epidemiological data and bolster patient recruitment for further development of this treatment strategy. PMID:26329152

  4. La Niña diversity and Northwest Indian Ocean Rim teleconnections

    Science.gov (United States)

    Hoell, Andrew; Funk, Christopher C.; Barlow, Mathew

    2014-01-01

    The differences in tropical Pacific sea surface temperature (SST) expressions of El Niño-Southern Oscillation (ENSO) events of the same phase have been linked with different global atmospheric circulation patterns. This study examines the dynamical forcing of precipitation during October–December (OND) and March–May (MAM) over East Africa and during December–March (DJFM) over Central-Southwest Asia for 1950–2010 associated with four tropical Pacific SST patterns characteristic of La Niña events, the cold phase of ENSO. The self-organizing map method along with a statistical distinguishability test was used to isolate La Niña events, and seasonal precipitation forcing was investigated in terms of the tropical overturning circulation and thermodynamic and moisture budgets. Recent La Niña events with strong opposing SST anomalies between the central and western Pacific Ocean (phases 3 and 4), force the strongest global circulation modifications and drought over the Northwest Indian Ocean Rim. Over East Africa during MAM and OND, subsidence is forced by an enhanced tropical overturning circulation and precipitation reductions are exacerbated by increases in moisture flux divergence. Over Central-Southwest Asia during DJFM, the thermodynamic forcing of subsidence is primarily responsible for precipitation reductions, with moisture flux divergence acting as a secondary mechanism to reduce precipitation. Eastern Pacific La Niña events in the absence of west Pacific SST anomalies (phases 1 and 2), are associated with weaker global teleconnections, particularly over the Indian Ocean Rim. The weak regional teleconnections result in statistically insignificant precipitation modifications over East Africa and Central-Southwest Asia.

  5. Out of the Blue: The Pacific Rim as a Region

    Directory of Open Access Journals (Sweden)

    Arturo Santa-Cruz

    2005-08-01

    Full Text Available In 1993, in advance of what was to be the first Asia Pacific Economic Cooperation (APEC leader’s summit, US president Bill Clinton gave a lecture at Waseda University in Japan. In his speech, Clinton called for the creation of a “community of the Pacific.” The idea of a Pacific community is neither Clinton’s nor the Democratic Party’s invention, however. In the previous decade Ronald Reagan had already used it, going even beyond later conceptualizations, by referring to the 21st century as the Pacific’s century. But Reagan's prophecy concerning the Great Ocean was not new back in the 1980s either. In 1900 then US Secretary of State John Hay wrote: “the Mediterranean is the ocean of the past, the Atlantic the ocean of the present and the Pacific is the ocean of the future.” In a more general manner, as Christopher Coker has observed, the notion of the “Century of the Pacific” is plausible because it is consistent with the idea, popularized by Hegel, that the spirit of civilization is moving toward that part of the globe. Thus, the century of the Pacific has become a kind of zeitgeist. In this paper I undertake a conceptual, historical, and theoretical journey through the “Pacific Rim” or “Asia-Pacific,” as it has been called more recently. Although I will question the utility of the term, I want to make clear that my purpose is only to undertake a critical survey of “the Pacific.” As in any trip, however, one needs a starting point. But, What is the starting point of the Pacific Rim, that geographic zone that has been compared to Pascal’s sphere: “with periphery indeterminable and a center that may be anywhere”?

  6. Surface and internal structures of a space-weathered rim of an Itokawa regolith particle

    Science.gov (United States)

    Matsumoto, Toru; Tsuchiyama, Akira; Miyake, Akira; Noguchi, Takaaki; Nakamura, Michihiko; Uesugi, Kentaro; Takeuchi, Akihisa; Suzuki, Yoshio; Nakano, Tsukasa

    2015-09-01

    Surface morphologies of a regolith particle retrieved from Asteroid 25143 Itokawa were observed using field-emission scanning electron microscopy (FE-SEM). The images were compared with the internal structures of the space-weathered rim of the same particle observed by transmission electron and scanning transmission electron microscopies (TEM/STEM) to investigate whether there is a direct link between the surface morphology and internal structure. FE-SEM observation showed that most of the particle surface is covered by convex spots less than 100 nm in size. TEM/STEM observation revealed that this particle has a space-weathered rim composed of partially amorphous structures with nano-Fe particles and vesicles. The vesicles swell the surface and form blisters that correspond to the spotted structures observed by FE-SEM. These observations indicate that a space-weathered rim with blisters can be observed by FE-SEM without using destructive methods. The observation of the space-weathered rim by FE-SEM also enabled us to obtain the distribution of the space-weathered rim on the particle surfaces. The existence of space-weathered rims on the opposing surfaces of the particle shows that most of the surfaces were directly exposed to the space environment by movement on the Itokawa surface. The depths of the blister locations and the chemical composition of the space-weathered rim indicate that the observed space-weathered rim with blisters was formed mainly by solar wind irradiation. The space-weathered rim analyzed in this study is thicker than those of Itokawa particles previously examined, indicating that the rim may has experienced longer solar wind exposure than those previously observed.

  7. Bone scans

    International Nuclear Information System (INIS)

    Oftentimes, in managing podiatric complaints, clinical and conventional radiographic techniques are insufficient in determining a patient's problem. This is especially true in the early stages of bone infection. Bone scanning or imaging can provide additional information in the diagnosis of the disorder. However, bone scans are not specific and must be correlated with clinical, radiographic, and laboratory evaluation. In other words, bone scanning does not provide the diagnosis but is an important bit of information aiding in the process of diagnosis. The more useful radionuclides in skeletal imaging are technetium phosphate complexes and gallium citrate. These compounds are administered intravenously and are detected at specific time intervals postinjection by a rectilinear scanner with minification is used and the entire skeleton can be imaged from head to toe. Minification allows visualization of the entire skeleton in a single image. A gamma camera can concentrate on an isolated area. However, it requires multiple views to complete the whole skeletal image. Recent advances have allowed computer augmentation of the data received from radionucleotide imaging. The purpose of this chapter is to present the current radionuclides clinically useful in podiatric patients

  8. Spinal metastatic lesion in cancer patients. Investigation based on statistical analysis by bone scintigrams

    International Nuclear Information System (INIS)

    In a series of 2,216 cancer patients undergoing bone scintigraphy after diagnosis of the primary malignant tumor, 558 (25.2%) were found to have abnormal vertebral accumulation of radioactivity during the clinical course. Abnormal radioactivity in the vertebrae was frequently noted in patients with prostatic and renal cancer. The lumbar vertebrae were the most frequent sites but the cervical vertebrae were also affected with prostatic cancer, the thoracic vertebrae with lung and prostatic cancer, the lumbar vertebrae with breast and prostatic cancer and the sacral vertebrae with uterine cervical and prostatic cancer. Of the 558 patients with abnormal spinal radioactivity, 221 were examined by CT scan; the accumulated radioactivity was identified as a metastatic lesion in 170 patients (76.9%). Abnormal radioactivity was identified as a metastatic lesion most often in lung cancer patients. The CT-diagnosed metastases were classified into 3 types: sclerotic (51 patients, 30.0%), osteolytic (112, 65.9%), and mixed (46, 27.1%). The sclerotic type was relatively frequent in uterine cervical cancer, less frequent in lung cancer, and not seen in head and neck or renal cancer patients. The osteolytic type was relatively frequent in lung and renal cancer and less frequent in uterine cervical and prostatic cancer patients. Of the patients with CT-diagnosed vertebral metastasis, 87.3% survived for 3 months and 66.2% for 6 months after the detection of abnormal bone scintigraphy. Survival was shorter in patients with lung or gastrointestinal cancer than in those with other types of tumors. Since the pathology of vertebral metastasis of malignant tumors differs according to the primary lesion, the metastatic nature must be considered in the choice of treatment. (author)

  9. MR-guided bone biopsy performed with a new coaxial drill system

    International Nuclear Information System (INIS)

    Purpose: To describe the development and clinical evaluation of a new, hand-powered or alternatively motor-driven, MRI and CT compatible percutaneous bone biopsy system. Materials and Methods: A new coaxial drill system (Cook Europe A/S) was designed for percutaneous, MR-guided bone biopsies and powered either by hand or an optional motor (10-250 rotations/minute using 6 bar [88.2 PSI] compressed air). The system has been used in 23 patients. Fourteen procedures were performed in a 1.5 T MR scanner (Philips-Gyroscan ACS-NT) which has an attached C-arm (Philips-BV 212-Angio) in case fluoroscopy is required, and 9 procedures in a CT scanner (Siemens-Somatom Plus). Results: Driven by hand or by the pneumatic motor unit, the system achieved safe and accurate MR-guided access to all of the lesions and was even able to penetrate osteosclerotic lesions. MR- or CT-guided percutaneous biopsy yielded a correct diagnosis in all but 5 cases. No procedural complications occurred. Conclusion: MR-guided percutaneous bone biopsy performed with the new coaxial drill system was found to be safe and reliable, and suitable for obtaining histological specimens from skeletal lesions even when covered with thick cortical or sclerotic bone. (orig.)

  10. Pinhole bone scan mapping of metabolic profiles in osteoarthritis of the knee: a radiographic correlation

    International Nuclear Information System (INIS)

    Osteoarthritis (OA) is mixture of damage to a joint and reaction induced therefrom. Heterogeneity, slow change and no proper means of assessing pathology make it a difficult disease to study. Diagnosis can be made by radiography when OA is established. But subtle metabolic change without radiographic alteration can only be detected by bone scan. Present study was performed to assess metabolic profiles of OA of the knee with various radiographic and preradiographic changes using pinhole bone scan (PBS). PBS and radiography were taken at the same time or a few days apart. We used single-head gamma camera and a 4-mm pinhole collimator. Patients were 9 men and 19 women (30-74 yr with mean being 55). PBS was correlated with radiography in each case. Increased tracer uptake was seen in 111 lesions in 28 knees. Intensity was arbitrarily graded into Grade 0-2. The results were divided into group with radiographic change (n=85; Table) and group without (n=26). Generally, tracer uptake was much intense in the sclerotic and cystic form. In radiographically normal group pathological uptake occurred mostly in subchondral bone (n=17) and some in the femoral condyle (n=9) denoting that subchondral bone is the most vulnerable. PBS is sensitive indicator of metabolic alternations in various disease processes of OA in both radiographically normal and abnormal cases

  11. Osteoid osteoma of a metacarpal bone: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Chronopoulos Efstathios

    2008-08-01

    Full Text Available Abstract Introduction Osteoid osteoma is a benign tumor of the growing skeleton. It presents with pain, which is usually worse at night. The radiographic features consist of a central oval or round nidus surrounded first by a radiolucent area followed by another area of sclerotic bone. In the hand, osteoid osteoma is more commonly located in the phalanges and carpal bones. The metacarpals are the least common sites for osteoid osteoma. Case presentation We present a case of an osteoid osteoma of the left third metacarpal bone in a 36-year-old woman. The clinical and radiographic findings along with the surgical management of the lesion are presented. The pain disappeared immediately after the operation. At the 2-year follow-up, the patient was pain-free and there was no evidence of recurrence. Conclusion Physicians should be aware of the unusual presence and the atypical clinical presentation of this benign lesion in the metacarpal bones of the hand.

  12. Solitary myofibroma of the lumbar vertebra: adult case

    Energy Technology Data Exchange (ETDEWEB)

    Konishi, E.; Yanagisawa, A. [Kyoto Prefectural University of Medicne, Department of Pathology, Kyoto (Japan); Mazaki, T.; Urata, Y. [Kyoto City Hospital, Department of Pathology, Kyoto (Japan); Tanaka, K.; Kanoe, H.; Ikenaga, M. [Kyoto City Hospital, Department of Orthopedic Surgery, Kyoto (Japan); Hayakawa, K. [Kyoto City Hospital, Department of Radiology, Kyoto (Japan)

    2007-06-15

    We present the first known adult case of solitary myofibroma of bone, which affected a lumbar vertebra in a 33-year-old male. Radiography identified a purely lytic lesion with a sclerotic rim in the right pedicle of L1. CT showed an expansile lytic lesion with a sclerotic rim. MRI of the lesion revealed an isointense signal on T1-weighted images, an inhomogeneously hyperintense signal on T2-weighted images, and marked enhancement with gadolinium. Pathological study showed a mixed picture of nodular proliferation of spindle-shaped myoid cells and hemangiopericytomatous proliferation of short spindle/small round cells. The tumor cells were immunoreactive for smooth muscle actin and immunonegative for desmin. This case of solitary myofibroma of bone is exceptionally rare because of its occurrence in an adult older than 20 years of age and its location at an extra-craniofacial site. (orig.)

  13. Solitary myofibroma of the lumbar vertebra: adult case

    International Nuclear Information System (INIS)

    We present the first known adult case of solitary myofibroma of bone, which affected a lumbar vertebra in a 33-year-old male. Radiography identified a purely lytic lesion with a sclerotic rim in the right pedicle of L1. CT showed an expansile lytic lesion with a sclerotic rim. MRI of the lesion revealed an isointense signal on T1-weighted images, an inhomogeneously hyperintense signal on T2-weighted images, and marked enhancement with gadolinium. Pathological study showed a mixed picture of nodular proliferation of spindle-shaped myoid cells and hemangiopericytomatous proliferation of short spindle/small round cells. The tumor cells were immunoreactive for smooth muscle actin and immunonegative for desmin. This case of solitary myofibroma of bone is exceptionally rare because of its occurrence in an adult older than 20 years of age and its location at an extra-craniofacial site. (orig.)

  14. CO observations of a molecular cloud complex associated with the bright rim near VY Canis Majoris

    International Nuclear Information System (INIS)

    Extensive CO observations of a large molecular cloud complex (approx. 15 pc) associated with a bright rim near the peculiar star VY CMa are presented. CO emission peaks in a region along and adjacent to the bright rim which forms the western border of the cloud complex. This emission abruptly decreases across the bright rim, and this decrease suggests a physical association of the rim with the cloud. The molecular complex is found to consist of two clouds which have different radial velocities and physical properties. The possibility that these two clouds may be in near-collision is discussed. The physical association of the bright rim with the cloud complex indicates that the clouds are at the same distance, 1.5 kpc, as the stars which excite the rim. Since VY CMa appears to be located at the tip of the bright rim and has a velocity similar to that of the molecular cloud complex and the stars of the cluster NGC 2362, it is concluded that VY CMa is also at the same distance. The resulting luminosity of VY CMa (5 x 105 L sub solar) indicates that the star is very massive, and places constraints on interpretation of its evolutionary state. 5 figures, 2 tables

  15. Near-IR Imaging Polarimetry toward a Bright-Rimmed Cloud: Magnetic Field in SFO 74

    CERN Document Server

    Kusune, Takayoshi; Miao, Jingqi; Tamura, Motohide; Sato, Yaeko; Kwon, Jungmi; Watanabe, Makoto; Nishiyama, Shogo; Nagayama, Takahiro; Sato, Shuji

    2014-01-01

    We have made near-infrared (JHKs) imaging polarimetry of a bright-rimmed cloud (SFO 74). The polarization vector maps clearly show that the magnetic field in the layer just behind the bright rim is running along the rim, quite different from its ambient magnetic field. The direction of the magnetic field just behind the tip rim is almost perpendicular to that of the incident UV radiation, and the magnetic field configuration appears to be symmetric as a whole with respect to the cloud symmetry axis. We estimated the column and number densities in the two regions (just inside and far inside the tip rim), and then derived the magnetic field strength, applying the Chandrasekhar-Fermi method. The estimated magnetic field strength just inside the tip rim, ~90 uG, is stronger than that far inside, ~30 uG. This suggests that the magnetic field strength just inside the tip rim is enhanced by the UV radiation induced shock. The shock increases the density within the top layer around the tip, and thus increases the str...

  16. Bone banking and sterilization of bones

    Science.gov (United States)

    Minamisawa, I.; Itoman, M.; Maehara, H.; Kobayashi, A.; Watanabe, T.

    1995-08-01

    The use of banked bone (preserved allograft bone) is various and essential, because it has numerous advantages including the relative ease in retrieval a large amount of bone material and requisite shape and size. But bone banking and allografting must be promoted under obligation to stably supply safe and high-quality bone. To avoid transferring disease perfectly, irradiation sterilization is especially recommended at the present time.

  17. Bone development.

    Science.gov (United States)

    Berendsen, Agnes D; Olsen, Bjorn R

    2015-11-01

    The development of the vertebrate skeleton reflects its evolutionary history. Cartilage formation came before biomineralization and a head skeleton evolved before the formation of axial and appendicular skeletal structures. This review describes the processes that result in endochondral and intramembranous ossification, the important roles of growth and transcription factors, and the consequences of mutations in some of the genes involved. Following a summary of the origin of cartilage, muscle, and tendon cell lineages in the axial skeleton, we discuss the role of muscle forces in the formation of skeletal architecture and assembly of musculoskeletal functional units. Finally, ontogenetic patterning of bones in response to mechanical loading is reviewed.This article is part of a Special Issue entitled "Muscle Bone Interactions". PMID:26453494

  18. COL1A1 C-propeptide cleavage site mutation causes high bone mass, bone fragility and jaw lesions: a new cause of gnathodiaphyseal dysplasia?

    Science.gov (United States)

    McInerney-Leo, A M; Duncan, E L; Leo, P J; Gardiner, B; Bradbury, L A; Harris, J E; Clark, G R; Brown, M A; Zankl, A

    2015-07-01

    Gnathodiaphyseal dysplasia (GDD) is a rare autosomal dominant condition characterized by bone fragility, irregular bone mineral density (BMD) and fibro-osseous lesions in the skull and jaw. Mutations in Anoctamin-5 (ANO5) have been identified in some cases. We aimed to identify the causative mutation in a family with features of GDD but no mutation in ANO5, using whole exome capture and massive parallel sequencing (WES). WES of two affected individuals (a mother and son) and the mother's unaffected parents identified a mutation in the C-propeptide cleavage site of COL1A1. Similar mutations have been reported in individuals with osteogenesis imperfecta (OI) and paradoxically increased BMD. C-propeptide cleavage site mutations in COL1A1 may not only cause 'high bone mass OI', but also the clinical features of GDD, specifically irregular sclerotic BMD and fibro-osseous lesions in the skull and jaw. GDD patients negative for ANO5 mutations should be assessed for mutations in type I collagen C-propeptide cleavage sites. PMID:24891183

  19. Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases

    Directory of Open Access Journals (Sweden)

    Akira Toriihara

    2015-07-01

    Full Text Available Temporal bone chondroblastoma is an extremely rare benign bone tumor. We encountered two cases showing similar imaging findings on computed tomography (CT, magnetic resonance imaging (MRI, and dual-time-point 18F-fluorodeoxyglucose (18F-FDG positron emission tomography (PET/CT. In both cases, CT images revealed temporal bone defects and sclerotic changes around the tumor. Most parts of the tumor showed low signal intensity on T2- weighted MRI images and non-uniform enhancement on gadolinium contrast-enhanced T1-weighted images. No increase in signal intensity was noted in diffusion-weighted images. Dual-time-point PET/CT showed markedly elevated 18F-FDG uptake, which increased from the early to delayed phase. Nevertheless, immunohistochemical analysis of the resected tumor tissue revealed weak expression of glucose transporter-1 and hexokinase II in both tumors. Temporal bone tumors, showing markedly elevated 18F-FDG uptake, which increases from the early to delayed phase on PET/CT images, may be diagnosed as malignant bone tumors. Therefore, the differential diagnosis should include chondroblastoma in combination with its characteristic findings on CT and MRI.

  20. LE RÔLE DE RIM101p DANS LA RÉPONSE AU pH CHEZ CANDIDA ALBICANS

    OpenAIRE

    Weyler, Michael

    2007-01-01

    Rim101p est un facteur de transcription qui est activé par cleavage N-terminale à pH alcalin. Il régule ainsi la réponse au pH et joue aussi un rôle majeur dans la pathogenèse de la levure Candida albicans. Mon projet est d'identifier et d'étudier des gènes de surface régulés par Rim101p qui ont une fonction dans l'interaction hôte-levure.Une analyse du transcriptome suite à l'induction d'une forme tronquée et constitutivement active de Rim101p nous avait permis d'identifier et de classer 133...

  1. RIM, Munc13, and Rab3A interplay in acrosomal exocytosis

    Energy Technology Data Exchange (ETDEWEB)

    Bello, Oscar D.; Zanetti, M. Natalia [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Mayorga, Luis S. [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Michaut, Marcela A., E-mail: mmichaut@fcm.uncu.edu.ar [Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Instituto de Ciencias Basicas, Universidad Nacional de Cuyo, Mendoza (5500) (Argentina)

    2012-03-10

    Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: Black-Right-Pointing-Pointer RIM and Munc13 are present in human sperm and localize to the acrosomal region. Black-Right-Pointing-Pointer RIM and Munc13 are necessary for acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Munc13 participate before the acrosomal calcium efflux. Black-Right-Pointing-Pointer RIM, Munc13 and Rab3A interplay in human sperm acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Rab3A have critical roles in membrane docking.

  2. Amphibole Reaction Rims in Response to Decompression compared to Heating: An Experimental Approach

    Science.gov (United States)

    Browne, B. L.; Gardner, J. E.; Larsen, J.

    2003-12-01

    Amphiboles are an important magmatic mineral phase common to a variety of volcanic settings, and are especially sensitive to variations in the water content and temperature of the surrounding induced during magmatic ascent or heating accompanying magma mixing events. As magma rises toward the surface hydrous amphiboles, stable at high water pressures, break down in response to degassing of the surrounding melt. Reaction rims also form around amphiboles that are destabilized when mixing with hotter, more primitive magmas occurs. In this study, we compare the thickness, composition, and rate of formation of amphibole reaction rims during a series of isothermal decompression and isobaric heating experiments using dacite and andesite magmas erupted from Redoubt volcano, Alaska in 1989-1990. The 1989-90 Redoubt dacite pumice consists of magnesio-hornblendes, plagioclase, othropyroxene, and Fe-Ti oxides in a high-silica rhyolite glass. In contrast, 1989-90 Redoubt andesite contains pargasitic amphiboles, orthopyroxene, clinopyroxene, plagioclase, and Fe-Ti oxides in a rhyodacite glass. Our results indicate that the reaction rims formed in response to decompression are distinguishable in thickness, grain size, and type of mineral formed in the rims from those formed in response to heating, regardless of the type of amphibole studied. First, decompression induced rims were thinner (5- 50 um) compared to those developing in response to heating (25- 200 um). Decompression induced rim growth rate ranges from 0.3 to 0.6 um/day compared to heating induced rim growth rate, which ranges from 0.4 to 1.6 um/day. Second, decompression rims were finer-grained (5-15 um diameter crystals) compared to heating reaction rims (5- 35 um diameter crystals). And third, decompression rims are predominantly composed of orthopyroxene and plagioclase, with lesser amounts of Fe-Ti oxides, whereas reaction rims that grew in response to heating experiments were composed almost entirely of clinopyroxene and Fe-Ti oxides, with lesser amounts of orthopyroxene, and plagioclase. Because the results are independent of the type of amphibole studied, the physical characteristics of reaction rims around amphiboles from a given eruption may yield important information about the rates and types of pre-eruptive disequilibrium event that was the cause.

  3. Crystal Structure of the RIM1? C2B Domain at 1.7 Å Resolution†,¶

    OpenAIRE

    Guan, Rong; Dai, Han; Diana R Tomchick; Dulubova, Irina; Machius, Mischa; Südhof, Thomas C.; Rizo, Josep

    2007-01-01

    RIM proteins play critical roles in synaptic vesicle priming and diverse forms of presynaptic plasticity. The C-terminal C2B domain is the only module that is common to all RIMs, but is only distantly related to well-studied C2 domains, and its three-dimensional structure and interactions have not been characterized in detail. Using NMR spectroscopy, we now show that N- and C-terminal extensions beyond the predicted C2B domain core sequence are necessary to form a folded, stable RIM1? C2B dom...

  4. Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release

    OpenAIRE

    Takao-Rikitsu, Etsuko; Mochida, Sumiko; Inoue, Eiji; Deguchi-Tawarada, Maki; Inoue, Marie; Ohtsuka, Toshihisa; TAKAI, Yoshimi

    2004-01-01

    We have recently isolated a novel cytomatrix at the active zone (CAZ)–associated protein, CAST, and found it directly binds another CAZ protein RIM1 and indirectly binds Munc13-1 through RIM1; RIM1 and Munc13-1 directly bind to each other and are implicated in priming of synaptic vesicles. Here, we show that all the CAZ proteins thus far known form a large molecular complex in the brain, including CAST, RIM1, Munc13-1, Bassoon, and Piccolo. RIM1 and Bassoon directly bind to the COOH terminus ...

  5. Bilateral primary xanthoma of the humeri with pathologic fractures: A case report

    OpenAIRE

    Ali, Sayed; Fedenko, Alex; Syed, Ali B; Matcuk, George; Patel, Dakshesh; Gottsegen, Chris; White, Eric

    2013-01-01

    Xanthomas are rare bone tumors that occur more often in the appendicular skeleton and typically appear radiographically benign, with a narrow zone of transition and a sclerotic rim. We report the case of a 57-year-old woman with hyperlipidemia presenting with bilateral shoulder pain after minor trauma. Radiographic and histopathologic investigation demonstrated intraosseous xanthoma with atypical features, including multifocality, a wide zone of transition and pathologic fractures-characteris...

  6. 3He film flow on a round rim beaker

    International Nuclear Information System (INIS)

    The superfluid properties of thin (100-150 nm) of 3He were investigated by measuring the rate at which a beaker of liquid 3He emptied itself through the adsorbed film, with the film thickness ? decreasing as the level dropped. A beaker rim with a semicircular cross-section was used to provide a well defined geometry and to avoid the effects of small scratches that may have affected earlier experiments. The film thicknesses were determined by Atkins' oscillation measurements of 4He films on the same surface. The superfluid transition temperature in the film TFc was suppressed below the bulk value TBc, and was close to being described by 2?/?(TFc) = ?, as expected for A-phase. The critical current density was more than an order of magnitude smaller than expected for pair-breaking. When a 4He monolayer was adsorbed on the substrate, there was no suppression of TFc and the critical current density was much larger. With or without the 4He monolayer an abrupt decrease in the flow rate was observed as the film thinned, which may be associated with the B to A-phase transition that should occur

  7. Human Rights in the Countries of the Southern Rim

    Directory of Open Access Journals (Sweden)

    Laura Feliu i Martínez

    1997-09-01

    Full Text Available After practically all of the southern-rim countries of the Mediterranean gained their independence, the process of national construction has been predicated on authoritarian regimes. These regimes justified both the use of force against political opposition and the limits on rights and liberties on the need for maintaining the unanimity of the people which had manifested itself during the struggles for liberation from the colonial yoke. Towards the end of the 1980s, the regional and international context seemed to presage a very much longed for opening-up of the political scene after some of these countries (Tunisia, Algeria and Jordan initiated a series of movements that pointed to their democratisation. The posterior evolution of events has crushed those hopes in every case, and only Morocco and Jordan (each with their respective limitations appear to have evolved towards a softening of repression. The excuse put forth from the collection of states in the region to justify the step backwards is the existence of two threats they must act with forcefulness before: the threat of Islamic “fundamentalism” and the desire of certain groups to boycott the on-going Israeli-Palestinian Peace Process.

  8. Maturity of the Crater Rim Walls as a Function of the Crater Size

    Science.gov (United States)

    Sim, C. K.; Kim, S. S.; Jeong, M.

    2015-11-01

    The median grain size retrieved from ground-based polarimetry and optical maturity (OMAT) of the interior rim walls of ~140 craters of various size. We discuss the relationship between maturation rate and crater size.

  9. 77 FR 18997 - Rim Lakes Forest Restoration Project; Apache-Sitgreavese National Forest, Black Mesa Ranger...

    Science.gov (United States)

    2012-03-29

    ...action or an alternative; (2) the location, design, and scheduling of the proposed thinning, burning, and road maintenance...and should clearly articulate the reviewer's concerns and contentions. The proposed Rim Lakes Forest Restoration Project is...

  10. Systematic Ion Irradiation Experiments to Olivine: Comparison with Space Weathered Rims of Itokawa Regolith Particles

    Science.gov (United States)

    Matsumoto, T.; Tsuchiyama, A.; Watanabe, N.; Yasuda, K.; Miyake, A.; Nakauchi, Y.; Okada, T.; Abe, M.; Yada, T.; Uesugi, M.; Karouji, Y.; Nakato, A.; Hashiguschi, M.; Kumagai, K.

    2015-11-01

    We performed H and He ion irradiation experiments using olivine fragments, in order to reveal formation time-scales of space weathered rims and formation processes of blisters by solar wind irradiation.

  11. The Anatomy and Bulk Composition of CAI Rims in the Vigarano (CV3) Chondrite

    Science.gov (United States)

    Ruzicka, A.; Boynton, W. V.

    1993-07-01

    A striking feature of Ca,Al-rich inclusions (CAIs) in chondrites is the presence of mineralogical layers that typically form rim sequences up to 50 micrometers thick [1]. Many ideas regarding the origin of CAI rims have been proposed, but none are entirely satisfactory. The detailed mineralogy and bulk compositions of relatively unaltered CAI rims in the Vigarano (CV3) chondrite described here provide constraints on hypotheses of rim formation. Rim Mineralogy: CAIs in Vigarano consist of melilite (mel)- and spinel (sp)- rich varieties, both of which are rimmed [2]. Around mel-rich objects, the layer sequence is CAI interior --> sp-rich layer (sometimes absent) --> mel/anorthite (anor) layer --> Ti-Al-rich clinopyroxene (Tpx) layer --> Al- diopside (Al-diop) layer --> olivine (ol) +/- Al-diop layer --> host matrix. The sequence around sp-rich objects differs from this in that the mel/anor layer is absent. Both the sp-rich layer around mel-cored CAIs and the cores of sp-rich CAIs in Vigarano are largely comprised of a fine-grained (anor layer is sometimes monomineralic, consisting of mel alone, or bimineralic, consisting of both mel and anor. Where bimineralic, anor typically occurs in the outer part of the layer. In places, anor (An(sub)99-100) has partially altered to nepheline and voids. Rim mel is systematically less gehlenitic than mel in the CAI interiors, especially compared to mel in the interior adjacent to the rims. The Tpx layer (>2 and up to 15 wt% TiO2) and Al-diop layer ( sp + fo --> sp + fo + anor or mel or Tpx) that does not correspond to observed rim sequences. It thus appears that (1) the rim region did not form through crystallization of molten CAIs; and (2) rim layers did not originate solely by the crystallization of a melt layer present on a solid CAI core [4,5]. References: [1] Wark D. A. and Lovering J. F. (1977) Proc. LSC 8th, 95-112. [2] Ruzicka A. and Boynton W. V. (1991) Meteoritics, 26, 390-391. [3] Stolper E. (1982) GCA, 46, 2159-2180. [4] Korina M. I. et al. (1982) LPS XIII, 399- 400. [5] Bunch T. E. and Chang S. (1980) Meteoritics, 15, 270- 271.

  12. Reaction rim growth on olivine in silicic melts: Implications for magma mixing

    Science.gov (United States)

    Coombs, M.L.; Gardner, J.E.

    2004-01-01

    Finely crystalline amphibole or pyroxene rims that form during reaction between silicic host melt and cognate olivine xenocrysts, newly introduced during magma mixing events, can provide information about the timing between mixing and volcanic eruptions. We investigated rim growth experimentally by placing forsteritic olivine in rhyolitic and rhyodacitic melts for times between 25 and 622 h at 50 and 150 MPa, H2O-saturated, at the Ni-NiO buffer. Rims of orthopyroxene microlites formed from high-silica rhyolite and rhyodacite melts at 885??C and 50 MPa, and in the rhyolite at 150 MPa and 885??C. Rims of amphibole with lesser orthopyroxene formed in the rhyolite at 150 MPa and 800??C and in the rhyodacite at 150 MPa and 885??C. Irregular, convolute olivine edges and mass balance between olivine, melt, and rim phases show that olivine partly dissolved at all conditions. Iron-rich zones at the exteriors of olivines, which increased in width parabolically with time, show that Fe-Mg interdiffusion occurring in olivines was not outpaced by olivine dissolution. Linear increases of the square of rim widths with time suggest that diffusion within the melt is the rate-controlling process for olivine dissolution and rim growth. Rims grew one-half to one order-of-magnitude faster when melt water contents were doubled, unless conditions were far above the liquidus. Rim growth rate in rhyolite increases from 0.055 ?? 0.01 ??m2/h at 885 ??C and 50 MPa to 0.64 ?? 0.13 ??m2/h at 800 ??C and 150 MPa. Melt composition has a lesser effect on rim growth rates, with growth rate increasing as melt SiO2 content decreases. Pyroxene rims on olivines in andesite erupted from Arenal volcano (Costa Rica) grew at a rate of 3.0 ?? 0.2 ??m2/h over an eleven-year period. This rate is faster than those of the experiments due to lower melt viscosity and higher temperatures, and suggests that a magma mixing event preceded the start of the eruption by days.

  13. Malignant bone tumors

    International Nuclear Information System (INIS)

    Clinicoroentgenologic semiotics of malignant bone tumors as well as metastatic bone tumors are presented. Diagnosis of malignant and metastatic bone tumors should be always complex, representing a result of cooperation of a physician, roentgenologist, pathoanatomist

  14. Food and Your Bones

    Science.gov (United States)

    ... You are here Home » Food and Your Bones Food and Your Bones The food that you eat ... taking multivitamins or supplements . Good-for-Your-Bones Foods Food Nutrient Dairy products such as low-fat ...

  15. Osteoporosis: The Bone Thief

    Science.gov (United States)

    ... of this makes your bones weaker. Who Has Osteoporosis? Ten million Americans have osteoporosis. They are mostly ... a bone. What Can I Do For My Osteoporosis? Treating osteoporosis means stopping the bone loss and ...

  16. Broken Bones (For Parents)

    Science.gov (United States)

    ... bone fragments in place. When Will a Broken Bone Heal? Fractures heal at different rates, depending upon ... doctor says it's OK. Back Continue Preventing Broken Bones Although fractures are a common part of childhood, ...

  17. Bone marrow biopsy

    Science.gov (United States)

    Biopsy - bone marrow ... A bone marrow biopsy may be done in the health care provider's office or in a hospital. The sample may be taken from the pelvic or breast bone. Sometimes, other areas are used. Marrow is removed ...

  18. On the Dark Rim Artifact in Dynamic Contrast-Enhanced MRI Myocardial Perfusion Studies

    OpenAIRE

    Di Bella, E.V.R.; Parker, D L; Sinusas, A. J.

    2005-01-01

    A dark band or rim along parts of the subendocardial border of the left ventricle (LV) and the myocardium has been noticed in some dynamic contrast-enhanced MR perfusion studies. The artifact is thought to be due to susceptibility effects from the gadolinium bolus, motion, or resolution, or a combination of these. Here motionless ex vivo hearts in which the cavity was filled with gadolinium are used to show that dark rim artifacts can be consistent with resolution effects alone.

  19. Impact of slippage on the morphology and stability of a dewetting rim.

    OpenAIRE

    Münch, A; Wagner, B.

    2011-01-01

    In this study lubrication theory is used to describe the stability and morphology of the rim that forms as a thin polymer film dewets from a hydrophobized silicon wafer. Thin film equations are derived from the governing hydrodynamic equations for the polymer to enable the systematic mathematical and numerical analysis of the properties of the solutions for different regimes of slippage and for a range of timescales. Dewetting rates and the cross sectional profiles of the evolving rims are de...

  20. A Compact Array imaging survey of southern bright-rimmed clouds

    OpenAIRE

    Thompson, M. A.; Urquhart, J. S.; White, G. J.

    2003-01-01

    We have carried out a radio-wavelength imaging survey of 45 bright-rimmed clouds (BRCs), using the Australia Telescope Compact Array to characterise the physical properties in their ionised boundary layers. We detected radio emission from a total of 25 clouds and using a combination of Digitised Sky Survey and mid-infrared MSX micron images classified the emission into that associated with the ionised cloud rims, that associated with embedded possible massive YSOs and that u...

  1. Distal Myopathy with Rimmed Vacuoles : Impaired O-Glycan Formation in Muscular Glycoproteins

    OpenAIRE

    Tajima, Youichi; Uyama, Eiichiro; Go, Shinji; Sato, Chihiro; Tao, Nodoka; Kotani, Masaharu; Hino, Hirotake; Suzuki, Akemi; Sanai¶, Yutaka; Kitajima, Ken; Sakuraba, Hitoshi

    2005-01-01

    Distal myopathy with rimmed vacuoles (DMRV), is an autosomal recessive disorder with early adult onset, displays distal dominant muscular involvement and is characterized by the presence of numerous rimmed vacuoles in the affected muscle fibers. The pathophysiology of DMRV has not been clarified yet, although the responsible gene was identified as that encoding UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase involved in the biosynthesis of sialic acids. To identify defective ca...

  2. Comparison of measurements of neuroretinal rim area between confocal laser scanning tomography and planimetry of photographs

    OpenAIRE

    Jonas, J.; Mardin, C; Grundler, A.

    1998-01-01

    BACKGROUND—To compare neuroretinal rim area measurements by confocal scanning laser tomography and planimetric evaluation of optic disc photographs.?METHODS—For 221 patients with primary and secondary open angle glaucoma, 72 subjects with ocular hypertension, and 139 normal subjects, the optic disc was morphometrically analysed by the confocal scanning laser tomograph HRT (Heidelberg retina tomograph) and by planimetric evaluation of stereo colour optic disc photographs.?RESULTS—Absolute rim ...

  3. Anorexia Nervosa and Bone

    OpenAIRE

    Misra, Madhusmita; Klibanski, Anne

    2014-01-01

    Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone mass, impaired bone structure and reduced bone strength, all of which contribute to increased fracture risk., Adolescents with AN have decreased rates of bone accrual compared with normal-weight controls, raising addition concerns of suboptimal peak bone mass and future bone health in this age group. Changes in lean mass and compartmental fat depots, hormonal alterations secondary to nutritional factors...

  4. HIV and Bone Metabolism

    OpenAIRE

    OFOTOKUN, IGHOVWERHA; Weitzmann, M Neale

    2011-01-01

    The skeleton is an organ whose integrity is maintained by constant lifelong renewal involving coordinated removal of worn bone by osteoclasts and resynthesis of new bone by osteoblasts. In young adult humans and animals this process is homeostatic with no net gain or loss of bone mass. With natural aging and exacerbated by numerous pathological conditions, bone removal exceeds bone formation, disrupting homeostasis and resulting in bone loss. Over time, skeletal decline reaches clinical signi...

  5. Magnetic Field Amplification in the Thin X-Ray Rims of SN 1006

    Science.gov (United States)

    Ressler, Sean M.; Katsuda, Satoru; Reynolds, Stephen P.; Long, Knox S.; Petre, Robert; Williams, Brian J.; Winkler, P. Frank

    2014-08-01

    Several young supernova remnants, including SN 1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50-100 ?G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, DvpropE ?. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the FWHM in terms of energy as FWHM \\propto Em_E? . Filament widths in SN 1006 decrease with energy; mE ~ -0.3 to -0.8, implying magnetic field amplification by factors of 10-50, above the factor of four expected in strong unmodified shocks. For SN 1006, the rapid shrinkage rules out magnetic damping models. It also favors short mean free paths (small diffusion coefficients) and strong dependence of D on energy (? >= 1).

  6. Magnetic-Field Amplification in the Thin X-ray Rims of SN1006

    CERN Document Server

    Ressler, Sean M; Reynolds, Stephen P; Long, Knox S; Petre, Robert; Williams, Brian J; Winkler, P Frank

    2014-01-01

    Several young supernova remnants (SNRs), including SN1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50 to $100 \\mu$G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic-field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic-field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, $D \\propto E^{\\mu}$. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the full widths at half maximum (FWHM) in terms of energy as FW...

  7. Magnetic field amplification in the thin X-ray rims of SN 1006

    International Nuclear Information System (INIS)

    Several young supernova remnants, including SN 1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50-100 ?G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, D?E ?. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the FWHM in terms of energy as FWHM ?E?mE. Filament widths in SN 1006 decrease with energy; mE ? –0.3 to –0.8, implying magnetic field amplification by factors of 10-50, above the factor of four expected in strong unmodified shocks. For SN 1006, the rapid shrinkage rules out magnetic damping models. It also favors short mean free paths (small diffusion coefficients) and strong dependence of D on energy (? ? 1).

  8. Multimodal imaging and clinical characteristics of bone lesions in POEMS syndrome

    Science.gov (United States)

    Shi, Xiao-Feng; Hu, Shu-Dong; Li, Jun-Min; Luo, Xian-Fu; Long, Zhang-Biao; Zhu, Yan; Xi, Xiao-Dong

    2015-01-01

    POEMS syndrome is a rare plasmacyte-associated disease, one of the major diagnostic criteria of which is sclerotic bone lesion. To detect bone lesions in POEMS syndrome, which imaging method should be routinely applied and what characteristics they display are still unconfirmed. We analyzed clinical data and imaging characteristics of bone lesions in 22 patients with POEMS using multimodal methods, including conventional X-ray, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT). Images on X-ray and CT exhibited plaque-like high-density for osteosclerotic lesions and punched-out low-density appearance for osteolytic ones. X-ray had advantage in detecting bone lesions in skull, extremity long bones, clavicle, and scapula, while CT could display sharp outline of lesions and was more sensitive than X-ray in detecting the small lesions. Osteosclerotic lesions on MRI demonstrated decreased signal intensity on both T1 and T2-weighted sequences, while osteolytic lesions or osteolytic part of mixed lesions showed high signal intensity on T2-weighted sequences. MRI had same sensitivity as CT, but with superiority in distinguishing the active osteolytic lesions from the osteosclerotic ones. PET-CT showed 18F-FDG uptake was normal in the majority of osteosclerotic lesions, and slightly increased in mixed ones, but obviously elevated in osteolytic ones. PET/CT was less sensitive in detecting osteosclerotic lesions than in detecting osteolytic ones. In conclusion, to detect bone lesions in POEMS, conventional X-ray scan should be first performed, further followed by more sensitive CT or MRI. PET-CT is optional when the osteolytic lesions are suspected. PMID:26221290

  9. Ossificans myositis: inflammatory changes and contrast enhancement of adjacent bone shown by MR imaging; Myosite ossifiante circonscrite: remaniements osseux deceles en IRM

    Energy Technology Data Exchange (ETDEWEB)

    David, H.; Jolles, E.; Le Friant, G.; Silvestre, A.; Sarrazin, J.L.; Gordoliani, Y.S. [Hopital des Armees du Val-de-Grace, 75 - Paris (France)

    1995-07-01

    The authors report a case of ossificans myositis, in which magnetic resonance imaging (MRI) showed inflammatory changes of the adjacent bone. T 1 weighted fat saturation sequence with gadolinium injection showed enhancement of medullary and cortical bone. This potentially mistaking pattern must be known, to avoid mis diagnosing with malignant osseous tumor, specially before achievement of the characteristic pattern of zonal maturation and its calcified rim. (authors). 15 refs., 6 figs.

  10. Rim 2/Hipa CACTA transposon display ; A new genetic marker technique in Oryza species

    Directory of Open Access Journals (Sweden)

    Lee Ju

    2005-03-01

    Full Text Available Abstract Background Transposons constitute the major fractions of repetitive sequences in eukaryotes, and have been crucial in the shaping of current genomes. Transposons are generally divided into two classes according to the mechanism underlying their transposition: RNA intermediate class 1 and DNA intermediate class 2. CACTA is a class 2 transposon superfamily, which is found exclusively in plants. As some transposons, including the CACTA superfamily, are highly abundant in plant species, and their nucleotide sequences are highly conserved within a family, they can be utilized as genetic markers, using a slightly modified version of the conventional AFLP protocol. Rim2 /Hipa is a CACTA transposon family having 16 bp consensus TIR sequences to be present in high copy numbers in rice genome. This research was carried out in order to develop a Rim2/Hipa CACTA-AFLP or Rim2/Hipa CACTA-TD (transposon display, hereafter Rim2/Hipa-TD protocol for the study of genetic markers in map construction and the study of genetic diversity in rice. Results Rim2/Hipa-TD generated ample polymorphic profiles among the different rice accessions, and the amplification profiles were highly reproducible between different thermocyclers and Taq polymerases. These amplification profiles allowed for clear distinction between two different ecotypes, Japonica and Indica, of Oryza sativa. In the analysis of RIL populations, the Rim2/Hipa-TD markers were found to be segregated largely in a dominant manner, although in a few cases, non-parental bands were observed in the segregating populations. Upon linkage analysis, the Rim2/Hipa-TD markers were found to be distributed in the regions proximal to the centromeres of the chromosomes. The distribution of the Rim2/Hipa CACTA elements was surveyed in 15 different Oryza species via Rim2/Hipa-TD. While Rim2/Hipa-TD yielded ample amplification profiles between 100 to 700 bp in the AA diploid Oryza species, other species having BB, CC, EE, BBCC and CCDD, profiles demonstrated that most of the amplified fragments were larger than 400 bp, and that our methods were insufficient to clearly distinguish between these fragments. However, the overall amplification profiles between species in the Oryza genus were fully distinct. Phenetic relationships among the AA diploid Oryza species, as evidenced by the Rim2/Hipa-TD markers, were matched with their geographical distributions. Conclusion The abundance of the Rim2/Hipa TIR sequences is very informative since the Rim2/Hipa-TD produced high polymorphic profiles with ample reproducibility within a species as well as between species in the Oryza genus. Therefore, Rim2/Hipa-TD markers can be useful in the development of high-density of genetic map around the centromeric regions. Rim2/Hipa-TD may also prove useful in evaluations of genetic variation and species relationships in the Oryza species.

  11. Bone and bone marrow involvement in sarcoidosis.

    Science.gov (United States)

    Yachoui, Ralph; Parker, Brian J; Nguyen, Thanhcuong T

    2015-11-01

    Bone and bone marrow involvement in sarcoidosis have been infrequently reported. We aimed to describe the clinical features, radiological descriptions, pathological examinations, and outcomes of three patients with osseous sarcoidosis and one patient with bone marrow sarcoidosis seen at our institution. Our case series included fluorodeoxyglucose positron emission tomography descriptions in assessing the whole-body extent of sarcoidosis. In the era of advanced imaging, large bone and axial skeleton sarcoidosis lesions are more common than previously reported. PMID:26248533

  12. Breast Cancer and Bone Loss

    Science.gov (United States)

    ... bone loss? Certain treatments for breast cancer can lead to bone loss because they decrease estrogen , the main female ... Why worry about bone loss? Bone loss can lead to fragile bones, a condition called osteoporosis. When someone has osteoporosis, ...

  13. Evaluation of radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT

    Science.gov (United States)

    Gunalp, Bengul; Oner, Ali Ozan; Ince, Semra; Alagoz, Engin; Ayan, Asl?; Arslan, Nuri

    2015-01-01

    Background. The aim of the study was to retrospectively evaluate radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT and determine their roles on the evaluation of therapy response. Patients and methods. We retrospectively evaluated radiographic and metabolic characteristics of bone metastases in 30 patients who were referred for the evaluation of response to systemic therapy with 18FDG-PET/CT. All patients underwent integrated 18FDG-PET/CT before and after treatment. Results. The baseline radiographic patterns of the target lesions in responders group were lytic, sclerotic, mixed and CT negative; after treatment the radiographic patterns of all target lesions changed to a sclerotic pattern and attenuation increased (p = 0.012) and metabolic activity decreased (p = 0.012). A correlation was found between decreasing metabolic activity and increasing attenuation of the target lesions (r = ?0.55) (p = 0.026). However, in nonresponders group, the baseline radiologic patterns of the target lesions were lytic, blastic, mixed and CT negative; after treatment all lytic target lesions remained the same and one CT negative lesion turned to lytic pattern and the attenuation of the target lesions decreased (p ± 0.12) and metabolic activity increased (p = 0.012). A correlation was found between increasing metabolic activity and decreasing attenuation (r = ?0.65) (p = 0.032). An exception of this rule was seen in baseline blastic metastases which progressed with increasing in size, metabolic activity and attenuation. Conclusions. This study shows that the metabolic activity of lesions is a more reliable parameter than the radiographic patterns for the evaluation of therapy response. PMID:26029021

  14. Evaluation of radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT

    International Nuclear Information System (INIS)

    The aim of the study was to retrospectively evaluate radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT and determine their roles on the evaluation of therapy response. We retrospectively evaluated radiographic and metabolic characteristics of bone metastases in 30 patients who were referred for the evaluation of response to systemic therapy with 18FDG-PET/CT. All patients underwent integrated 18FDG-PET/CT before and after treatment. The baseline radiographic patterns of the target lesions in responders group were lytic, sclerotic, mixed and CT negative; after treatment the radiographic patterns of all target lesions changed to a sclerotic pattern and attenuation increased (p = 0.012) and metabolic activity decreased (p = 0.012). A correlation was found between decreasing metabolic activity and increasing attenuation of the target lesions (r = ?0.55) (p = 0.026). However, in nonresponders group, the baseline radiologic patterns of the target lesions were lytic, blastic, mixed and CT negative; after treatment all lytic target lesions remained the same and one CT negative lesion turned to lytic pattern and the attenuation of the target lesions decreased (p ± 0.12) and metabolic activity increased (p = 0.012). A correlation was found between increasing metabolic activity and decreasing attenuation (r = ?0.65) (p = 0.032). An exception of this rule was seen in baseline blastic metastases which progressed with increasing in size, metabolic activity and attenuation. This study shows that the metabolic activity of lesions is a more reliable parameter than the radiographic patterns for the evaluation of therapy response

  15. Subperiosteal ganglion associated with Paget's disease of bone

    International Nuclear Information System (INIS)

    Tumoral lesions related to Paget's disease may be classified as malignant, benign or pseudotumoral. While sarcomatous degeneration is the most feared complication, awareness of benign and pseudotumoral lesions is essential for assisting in accurate histological interpretation of the biopsy sample, which may avoid unnecessary repeat biopsies. We present the first case of a juxta-articular subperiosteal ganglion associated with Paget's disease, with classic imaging characteristics, especially on CT examination. The well-defined soft tissue mass at the medial aspect of the obturator rim, adjacent to a small fracture in pagetic quadrilateral plate, showed an ossified rim and internal gas lucencies, these being the hallmarks of a juxta-articular subperiosteal ganglion. On MRI, the lesion was of intermediate signal intensity on T1-weighted sequences, increased signal intensity on T2-weighted sequences, with rim enhancement after gadolinium contrast injection and preservation of fatty marrow signal of the underlying pagetic bone. Identification of the entity avoided an unnecessary biopsy or surgical intervention. (orig.)

  16. Paget's sarcoma of bone

    International Nuclear Information System (INIS)

    The most sinister complication of Paget's disease is malignant degeneration. The true etiology of Paget's disease remains unproven and unknown. The relative incidence of sarcoma ranges from 0.9% to 20% depending upon the population source. The anatomical distribution of lesions is similar to that of uncomplicated Paget's disease except for the high incidence in the humerus and rare occurrence in the spine. Approximately 50% of the lesions histologically represent osteosarcomas, with fibrosarcoma, fibrous histiocytoma, chondrosarcoma and giant cell tumor rarely occurring. The radiographic presentation is most commonly lytic, but sclerotic and mixed patterns occur. Cortical destruction and soft tissue mass are the cardinal radiographic signs. Malignant periosteal response is seldom found associated with Paget's sarcoma. The most common sites are femur, humerus, pelvis, skull and tibia. The prognosis is fatal at a very rapid rate. There are but a few isolated cases of long-term survival reported. (orig.)

  17. Bone Marrow Transplantation

    Science.gov (United States)

    Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The ... platelets, which help the blood to clot. A bone marrow transplant is a procedure that replaces a ...

  18. Bone Marrow Diseases

    Science.gov (United States)

    Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The ... help with blood clotting. If you have a bone marrow disease, there are problems with the stem ...

  19. BONE IN OSTEOPETROSIS

    Directory of Open Access Journals (Sweden)

    Ramkumar

    2014-04-01

    Full Text Available Osteopetrosis, a generalized developmental bone disease due to genetic disturbances, characterized by failure of bone re sorption and continuous bone formation making the bone hard, dense and brittle. Bones of intramembranous ossification and enchondrial ossification are affected genetically and symmetrically. During the process of disease the excess bone formation obliterates the cranial foramina and presses the optic, auditory and facial nerves resulting in defective vision, impaired hearing and facial paralysis. The bone formation in osteopetrosis affects bone marrow function leading to severe anemia and deficient of blood cells. The bone devoid of blood supply due to compression of blood vessels by excess formation of bone are prone to osteomyelitic changes with suppuration and pathological fracture if exposed to infection. Though the condition is chronic progressive, it produces changes leading to fatal condition, it should be studied thoroughly by everyone and hence this article presents a classical case of osteopetrosis with detailed description and discussion for the benefit of readers

  20. Does running strengthen bone?

    Science.gov (United States)

    Boudenot, Arnaud; Achiou, Zahra; Portier, Hugues

    2015-12-01

    Bone is a living tissue needing mechanical stress to maintain strength. Traditional endurance exercises offer only modest effects on bone. Walking and running produce low impact but lead to bone fatigue. This article is specifically addressed to therapists and explains the mechanisms involved for the effects of exercise on bone. Intermittent exercise limits bone fatigue, and downhill exercises increase ground impact forces and involve eccentric muscle contractions, which are particularly osteogenic. PMID:26562001

  1. Bisphosphonate-Related Osteonecrosis of the Jaw Bone: Radiological Pattern and the Potential Role of CBCT in Early Diagnosis

    Directory of Open Access Journals (Sweden)

    James Olutayo

    2010-04-01

    Full Text Available Objectives: To systematize the clinico-radiological symptoms and course of bisphosphonate-related osteonecrosis of jaw bone and to evaluate the diagnostic potential of various radiological techniques to detect mild osteonecrosis in each stage of the disease.Material and Methods: The sample consisted of 22 patients previously diagnosed with extraoral malignant disease. Diagnosis was based on a clinical examination in conjunction to digital panoramic radiography and cone beam computed tomography (CBCT. Two dentomaxillofacial radiologists reviewed all images.Results: Twenty patients showed mandibular involvement clinically, while two others had a maxillary involvement. Four stages of the disease were proposed based on the clinico-radiological findings. Subclinical cortical and lamina dura thickening was detected with only three-dimensional CBCT and periapical images, while ulceration and cortical bone thickening was detected only by three-dimensional CBCT. Mixed sclerotic, lytic bone destruction involving alveolar and basal bone with or without encroachment on the mandibular canal, pathological mandibular fractures were detected by two-dimensional panoramic and three-dimensional CBCT images. Other findings are non healing extraction sockets, periapical radiolucencies, osteolysis, sequestra, oroantral fistula, and periosteal new bone formation.Conclusions: The present study showed that bisphosphonate-related osteonecrosis of jaw bone occurs in four distinct clinico-radiological stages. For mild cases, panoramic image diagnosis was much less obvious, whereas cone beam computed tomography was able to fully characterise the bony lesions and describe their extent and involvement of neighbouring structures in all cases. Thus cone beam computed tomography might better contribute to the prevention of bisphosphonate-related osteonecrosis of jaw bone as well to the disease management.

  2. MRI of degenerative bone marrow lesions in experimental osteoarthritis of canine knee joints

    International Nuclear Information System (INIS)

    Objective. The objective of this study was to determine the value of MRI in the detection of degenerative bone marrow abnormalities in an animal osteoarthritis model. Design. In 10 dogs with experimentally induced unilateral osteoarthritis of the knee, MRI was performed using two-dimensional spin-echo (2D-SE) and three-dimensional gradient-echo (3D-GE) imaging. Contrast enhanced T1-weighted 2D-SE sequences were also obtained after injection of gadolinium-DTPA. The results were compared with the gross and histopathologic findings and with radiography. Results. Histopathologic specimens revealed 21 osteosclerotic lesions and 5 intraosseous cysts. On 2D-SE images, 24 of 26 lesions were detected, while 21 of 26 lesions were identified on 2D-GE sequences. Radiography, including conventional tomography, demonstrated 9 of 26 lesions. Regardless of the sequence weighting, all osteosclerotic lesions appeared hypointense on MRI. Signal loss in bone sclerosis resulted primarily from the reduction of intact fat marrow, the increased bone density being of secondary importance. Quantitative signal analysis allowed approximate estimation of the grade of sclerosis. On postcontrast images, sclerotic bone remained hypointense, although significant but non-specific enhancement relative to the normal fat marrow was observed. The extent of contrast enhancement did not correlate with the grade of osteosclerosis. All five cysts were readily diagnosed by MRI. Cysts displayed either central or marginal contrast enhancement within their cavities. Conclusions. MRI provides a sensitive method for the diagnosis of osteoarthritic bone abnormalities, allowing their differentiation from most non-degenerative subarticular lesions. (orig.). With 1 tab

  3. Rim structure formation and high burnup fuel behavior of large-grained UO2 fuels

    International Nuclear Information System (INIS)

    Irradiation-induced fuel microstructural evolution of the sub-divided grain structure, or rim structure, of large-grained UO2 pellets has been examined through detailed PIEs. Besides standard grain size pellets with a grain size range of 9-12 ?m, two types of undoped and alumino-silicate doped large-grained pellets with a range of 37-63 ?m were irradiated in the Halden heavy water reactor up to a cross-sectional pellet average burnup of 86 GWd/t. The effect of grain size on the rim structure formation was quantitatively evaluated in terms of the average Xe depression in the pellet outside region measured by EPMA, based on its lower sensitivity for Xe enclosed in the coarsened rim bubbles. The Xe depression in the high burnup pellets above 60 GWd/t was proportional to d-0.5-d-1.0 (d: grain size), and the two types of large-grained pellets showed remarkable resistance to the rim structure formation. A high density of dislocations preferentially decorated the as-fabricated grain boundaries and the sub-divided grain structure was localized there. These observations were consistent with our proposed formation mechanism of rim structure, in which tangled dislocation networks are organized into the nuclei for recrystallized or sub-divided grains. In addition to higher resistance to the microstructure change, the large-grained pellets showed a smaller swelling rate at higher burnups and a lower fission gas release during base irradiation

  4. Impact of slippage on the morphology and stability of a dewetting rim

    Energy Technology Data Exchange (ETDEWEB)

    Muench, Andreas [Mathematical Institute, University of Oxford, Oxford (United Kingdom); Wagner, Barbara, E-mail: wagnerb@wias-berlin.de [Weierstass Institute, Mohrenstrasse 39, 10117 Berlin (Germany)

    2011-05-11

    In this study lubrication theory is used to describe the stability and morphology of the rim that forms as a thin polymer film dewets from a hydrophobized silicon wafer. Thin film equations are derived from the governing hydrodynamic equations for the polymer to enable the systematic mathematical and numerical analysis of the properties of the solutions for different regimes of slippage and for a range of timescales. Dewetting rates and the cross sectional profiles of the evolving rims are derived for these models and compared to experimental results. Experiments also show that the rim is typically unstable in the spanwise direction and develops thicker and thinner parts that may grow into 'fingers'. Linear stability analysis as well as nonlinear numerical solutions are presented to investigate shape and growth rate of the rim instability. It is demonstrated that the difference in morphology and the rate at which the instability develops can be directly attributed to the magnitude of slippage. Finally, a derivation is given for the dominant wavelength of the bulges along the unstable rim.

  5. Impact of slippage on the morphology and stability of a dewetting rim

    International Nuclear Information System (INIS)

    In this study lubrication theory is used to describe the stability and morphology of the rim that forms as a thin polymer film dewets from a hydrophobized silicon wafer. Thin film equations are derived from the governing hydrodynamic equations for the polymer to enable the systematic mathematical and numerical analysis of the properties of the solutions for different regimes of slippage and for a range of timescales. Dewetting rates and the cross sectional profiles of the evolving rims are derived for these models and compared to experimental results. Experiments also show that the rim is typically unstable in the spanwise direction and develops thicker and thinner parts that may grow into 'fingers'. Linear stability analysis as well as nonlinear numerical solutions are presented to investigate shape and growth rate of the rim instability. It is demonstrated that the difference in morphology and the rate at which the instability develops can be directly attributed to the magnitude of slippage. Finally, a derivation is given for the dominant wavelength of the bulges along the unstable rim.

  6. Modelling of Rim-layer features in frames of START-3 code development

    International Nuclear Information System (INIS)

    'Rim-effect' is a conventional term implying a number of microstructure and thermal physical phenomena, oriented from the periphery of a highly irradiated LWR fuel pellet, also called 'rim layer', 'rim', 'high burnup structure' (HBS) etc. One of the rim-effect consequences, important for fuel reliability, is evident intensification of fission gas release (FGR) and increase of rod internal pressure after certain threshold of fuel burnup. Results from post irradiation examinations (PIE) of WWER fuel demonstrate this tendency in a range of rod average burnup from 42-45 MWd/kgU to 60-65 Mwd/kgU. A recently developed dynamic model of FGR behavior based on analysis of a number of interrelated microstructure processes, differing by their rates and magnitudes and depending on external operational conditions, is briefly described in this paper. A verification of the model is performed using experimental data on matrix xenon EPMA and on fuel porosity. The verified model is integrated in the START-3 code and full-scale calculations of FGR are performed with the code. The developed model has demonstrated a good prediction for some important parameter of rim microstructure and for values of integral fission gas release in highly irradiated WWER fuel rods

  7. Seamless Rim-Functionalization of h-BN with Silica-Experiment and Theoretical Modeling.

    Science.gov (United States)

    Furlotti, Michele; Caputo, Riccarda; Krumeich, Frank; Nesper, Reinhard

    2015-05-18

    Boron nitride contains six-ring layers, which are isostructural to graphene, and it exhibits similar extraordinary mechanical strength. Unlike graphene, hexagonal boron nitride (h-BN) is an insulator and has some polar features that make it a perfect material for those applications graphene is not suitable for, for example, purely ionic conductors, insulating membranes, transparent coatings, composite ceramics, high oxidation resistance materials. We report here a selective rim-functionalization of h-BN with SiO2 by using the Stöber process. A closed, protruding ring of SiO2 is formed covering all edges perpendicular to the [001] zones of the h-BN stacks and thus shield the most reactive centers of BN layers. SEM and HAADF-STEM images, X-ray spectroscopy, and atomic force microscopy confirm the rim-functionalization by SiO2 . XRD demonstrates the absence of any intercalation phenomenon of BN and reveals the glassy nature of the SiO2 rims. Selected variations of synthesis and theoretical modeling both confirm that rim activation by water prior to the Stöber condensation is crucial. First-principles calculations also confirm that dangling bonds of clean BN edges merge to give interlayer bonds that make further functionalization much more difficult. The reported reaction pathway should allow for other new functionalizations of pure BN and of the rimmed SiO2 /h-BN composites. PMID:25873400

  8. Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution.

    Science.gov (United States)

    Guan, Rong; Dai, Han; Tomchick, Diana R; Dulubova, Irina; Machius, Mischa; Südhof, Thomas C; Rizo, Josep

    2007-08-01

    RIM proteins play critical roles in synaptic vesicle priming and diverse forms of presynaptic plasticity. The C-terminal C2B domain is the only module that is common to all RIMs but is only distantly related to well-studied C2 domains, and its three-dimensional structure and interactions have not been characterized in detail. Using NMR spectroscopy, we now show that N- and C-terminal extensions beyond the predicted C2B domain core sequence are necessary to form a folded, stable RIM1alpha C2B domain. We also find that the isolated RIM1alpha C2B domain is not sufficient for previously described protein-protein interactions involving the RIM1alpha C-terminus, suggesting that additional sequences adjacent to the C2B domain might be required for these interactions. However, analytical ultracentrifugation shows that the RIM1alpha C2B domain forms weak dimers in solution. The crystal structure of the RIM1alpha C2B domain dimer at 1.7 A resolution reveals that it forms a beta-sandwich characteristic of C2 domains and that the unique N- and C-terminal extensions form a small subdomain that packs against the beta-sandwich and mediates dimerization. Our results provide a structural basis to understand the function of RIM C2B domains and suggest that dimerization may be a crucial aspect of RIM function. PMID:17630786

  9. Estrogen and bone metabolism.

    Science.gov (United States)

    Väänänen, H K; Härkönen, P L

    1996-05-01

    Estrogen plays an important role in the growth and maturation of bone as well as in the regulation of bone turnover in adult bone. During bone growth estrogen is needed for proper closure of epiphyseal growth plates both in females and in males. Also in young skeleton estrogen deficiency leads to increased osteoclast formation and enhanced bone resorption. In menopause estrogen deficiency induces cancellous as well as cortical bone loss. Highly increased bone resorption in cancellous bone leads to general bone loss and destruction of local architecture because of penetrative resorption and microfractures. In cortical bone the first response of estrogen withdrawal is enhanced endocortical resorption. Later, also intracortical porosity increases. These lead to decreased bone mass, disturbed architecture and reduced bone strength. At cellular level in bone estrogen inhibits differentiation of osteoclasts thus decreasing their number and reducing the amount of active remodeling units. This effect is probably mediated through some cytokines, IL-1 and IL-6 being strongest candidates. Estrogen regulates the expression of IL-6 in bone marrow cells by a so far unknown mechanism. It is still uncertain if the effects of estrogen on osteoblasts is direct or is due to coupling phenomenon between bone formation to resorption. PMID:8865143

  10. Oxytocin and bone.

    Science.gov (United States)

    Colaianni, Graziana; Sun, Li; Zaidi, Mone; Zallone, Alberta

    2014-10-15

    One of the most meaningful results recently achieved in bone research has been to reveal that the pituitary hormones have profound effect on bone, so that the pituitary-bone axis has become one of the major topics in skeletal physiology. Here, we discuss the relevant evidence about the posterior pituitary hormone oxytocin (OT), previously thought to exclusively regulate parturition and breastfeeding, which has recently been established to directly regulate bone mass. Both osteoblasts and osteoclasts express OT receptors (OTR), whose stimulation enhances bone mass. Consistent with this, mice deficient in OT or OTR display profoundly impaired bone formation. In contrast, bone resorption remains unaffected in OT deficiency because, even while OT stimulates the genesis of osteoclasts, it inhibits their resorptive function. Furthermore, in addition to its origin from the pituitary, OT is also produced by bone marrow osteoblasts acting as paracrine-autocrine regulator of bone formation modulated by estrogens. In turn, the power of estrogen to increase bone mass is OTR-dependent. Therefore, OTR(-/-) mice injected with 17?-estradiol do not show any effects on bone formation parameters, while the same treatment increases bone mass in wild-type mice. These findings together provide evidence for an anabolic action of OT in regulating bone mass and suggest that bone marrow OT may enhance the bone-forming action of estrogen through an autocrine circuit. This established new physiological role for OT in the maintenance of skeletal integrity further suggests the potential use of this hormone for the treatment of osteoporosis. PMID:25209411

  11. Stability of one-plate fixation for zygomatic bone fracture

    International Nuclear Information System (INIS)

    We performed a comparative study of clinical zygomatic bone stability following open reduction by one-plate versus multiple-plate fixation. This retrospective study utilized cephalometric radiographs of three dimensional CT which were taken within 1 week and more than 2 months postoperatively. Twenty-three patients who sustained unilateral simple zygomatic bone fracture and underwent open reduction in our unit were included in this study. Of these patients, 15 fractures were fixed using one mini-plate, and 8 fractures were fixed using two or three mini-plates. All of the patients in the multiple-fixation group sustained simple zygomatic bone fractures, besides impure type blow out fractures (3 cases), or open wounds around the orbital rim (5 cases). Two measurements representing vertical and horizontal changes were obtained to evaluate postoperative zygomatic bone movement. Statistical analyses of cephalometric measurements (vertical and horizontal) did not show any significant differences between the two groups. These findings suggested that one-plate fixation for zygomatic bone fracture was sufficiently rigid when the fracture was not comminuted and three-point alignment could be achieved. (author)

  12. Cracking of an Aircraft Wheel Rim Made From Al-Alloy 2014-T6

    Directory of Open Access Journals (Sweden)

    G. Kosec

    2010-10-01

    Full Text Available Generally failures of different aircraft components and parts are revealed and examined by the use of non-destructive examination methods. In further detailed explanation and interpretation of failures optical and scanning electron microscopy are used. This paper deals with a problem of a crack on aircraft wheel rim made from aluminium alloy 2014-T6.The crack was observed during regular control by the maintenance unit for non-destructive examination of the Slovenian air carrier Adria Airways. The crack on the rim of an aircraft wheel investigated was a typical fatigue crack. At same time a numerous pits were found which served as stress concentrations on the rim surface.

  13. Tectonic setting of synorogenic gold deposits of the Pacific Rim

    Science.gov (United States)

    Goldfarb, R.J.; Phillips, G.N.; Nokleberg, W.J.

    1998-01-01

    More than 420 million oz of gold were concentrated in circum-Pacific synorogenic quartz loades mainly during two periods of continental growth, one along the Gondwanan margin in the Palaeozoic and the other in the northern Pacific basin between 170 and 50 Ma. These ores have many features in common and can be grouped into a single type of lode gold deposit widespread throughout clastic sedimentary-rock dominant terranes. The auriferous veins contain only a few percent sulphide minerals, have gold:silver ratios typically greater than 1:1, show a distinct association with medium grade metamorphic rocks, and may be associated with large-scale fault zone. Ore fluids are consistently of low salinity and are CO2-rich. In the early and middle Palaeozoic in the southern Pacific basin, a single immense turbidite sequence was added to the eastern margin of Gondwanaland. Deformation of these rocks in southeastern Australia was accompanied by deposition of at least 80 million oz of gold in the Victorian sector of the Lachlan fold belt mainly during the Middle and Late Devonian. Lesser Devonian gold accumulations characterized the more northerly parts of the Gondwanan margin within the Hodgkinson-Broken River and Thomson fold belts. Additional lodes were emplaced in this flyschoid sequence in Devonian or earlier Palaeozoic times in what is now the Buller Terrane, Westland, New Zealand. Minor post-Devonian growth of Gondwanaland included terrane collision and formation of gold-bearing veins in the Permian in Australia's New England fold belt and in the Jurassic-Early Cretaceous in New Zealand's Otago schists. Collision and accretion of dozens of terranes for a 100-m.y.-long period against the western margin of North America and eastern margin of Eurasia led to widespread, lattest Jurassic to Eocene gold veining in the northern Pacific basin. In the former location, Late Jurassic and Early Cretaceous veins and related placer deposits along the western margin of the Sierra Nevada batholith have yielded more than 100 million oz of gold. Additional significant ore-forming events during the development of North America's Cordilleran orogen included those in the Klamath Mountains region, California in the Late Jurassic and Early Cretaceous; the Klondike district, Yukon by the Early Cretaceous; the Nome and Fairbanks districts, Alaska, and the Bridge River district, British Columbia in the middle Cretaceous; and the Juneau gold belt, Alaska in the Eocene. Gold-bearing veins deposited during the Late Jurassic and Early Cretaceous terrane collision that formed the present-day Russian Far East have been the source for more than 130 million oz of placer gold. The abundance of gold-bearing quartz-carbonate veins throughout the Gondwanan, North American and Eurasian continental margins suggests the migration and concentration of large fluid volumes during continental growth. Such volumes could be released during orogenic heating of hydrous silicate mineral phases within accreted marine strata. The common temporal association between gold veining and magmatism around the Pacific Rim reflects these thermal episodes. Melting of the lower thickened crust during arc formation, slab rollback and extensional tectonism, and subduction of a slab window beneath the seaward part of the forearc region can all provide the required heat for initation of the ore-forming processes.

  14. Crystal structure of the RIM2 C2A-domain at 1.4 A resolution.

    Science.gov (United States)

    Dai, Han; Tomchick, Diana R; García, Jesús; Südhof, Thomas C; Machius, Mischa; Rizo, Josep

    2005-10-18

    RIMs are large proteins that contain two C2-domains and are localized at presynaptic active zones, where neurotransmitters are released. RIMs play key roles in synaptic vesicle priming and regulation of presynaptic plasticity. A mutation in the RIM1 C2A-domain has been implicated in autosomal dominant cone-rod dystrophy (CORD7). The RIM C2A-domain does not contain the full complement of aspartate residues that commonly mediate Ca2+ binding at the top loops of C2-domains, and has been reported to interact with SNAP-25 and synaptotagmin 1, two proteins from the Ca2+-dependent membrane fusion machinery. Here we have used NMR spectroscopy and X-ray crystallography to analyze the structure and biochemical properties of the RIM2 C2A-domain, which is closely related to the RIM1 C2A-domain. We find that the RIM2 C2A-domain does not bind Ca2+. Moreover, little binding of the RIM2 C2A-domain to SNAP-25 and to the C2-domains of synaptotagmin 1 was detected by NMR experiments, suggesting that as yet unidentified interactions of the RIM C2A-domain mediate its function. The crystal structure of the RIM2 C2A-domain using data to 1.4 A resolution reveals a beta-sandwich that resembles those observed for other C2-domains, but exhibits a unique dipolar distribution of electrostatic charges whereby one edge of the beta-sandwich is highly positive and the other edge is highly negative. The location of the mutation site implicated in CORD7 at the bottom of the domain and the pattern of sequence conservation suggest that, in contrast to most C2-domains, the RIM C2A-domains may function through Ca2+-independent interactions involving their bottom face. PMID:16216076

  15. Young Stellar Population of the Bright-Rimmed Clouds BRC 5, BRC 7 and BRC 39

    OpenAIRE

    Panwar, Neelam; Chen, W. P.; Pandey, A.K.; Samal, M. R.; Ogura, K; Ojha, D. K.; Jose, J.; Bhatt, B. C.

    2014-01-01

    Bright-rimmed clouds (BRCs), illuminated and shaped by nearby OB stars, are potential sites of recent/ongoing star formation. Here we present an optical and infrared photometric study of three BRCs: BRC 5, BRC 7 and BRC 39 to obtain a census of the young stellar population, thereby inferring the star formation scenario, in these regions. In each BRC, the Class I sources are found to be located mostly near the bright rim or inside the cloud, whereas the Class II sources are p...

  16. Bone fragility and imaging techniques

    OpenAIRE

    D’Elia, Giovanni; Caracchini, Giuseppe; Cavalli, Loredana; Innocenti, Paolo

    2009-01-01

    Bone fragility is a silent condition that increases bone fracture risk, enhanced by low bone mass and microarchitecture deterioration of bone tissue that lead to osteoporosis. Fragility fractures are the major clinical manifestation of osteoporosis.

  17. Amphibole reaction rims as a record of pre-eruptive magmatic heating: An experimental approach

    Science.gov (United States)

    De Angelis, S. H.; Larsen, J.; Coombs, M.; Dunn, A.; Hayden, L.

    2015-09-01

    Magmatic minerals record the pre-eruptive timescales of magma ascent and mixing in crustal reservoirs and conduits. Investigations of the mineral records of magmatic processes are fundamental to our understanding of what controls eruption style, as ascent rates and magma mixing processes are well known to control and/or trigger potentially hazardous explosive eruptions. Thus, amphibole reaction rims are often used to infer pre-eruptive magma dynamics, and in particular to estimate magma ascent rates. However, while several experimental studies have investigated amphibole destabilization during decompression, only two investigated thermal destabilization relevant to magma mixing processes. This study examines amphibole decomposition experimentally through isobaric heating of magnesio-hornblende phenocrysts within a natural high-silica andesite glass. The experiments first equilibrated for 24 h at 870 °C and 140 MPa at H2O-saturated conditions and ƒO2 ? Re-ReO prior to rapid heating to 880, 900, or 920 °C and hold times of 3-48 h. At 920 °C, rim thicknesses increased from 17 ?m after 3 h, to 55 ?m after 12 h, and became pseudomorphs after longer durations. At 900 °C, rim thicknesses increased from 7 ?m after 3 h, to 80 ?m after 24 h, to pseudomorphs after longer durations. At 880 °C, rim thicknesses increased from 7 ?m after 3 h, to 18 ?m after 36 h, to pseudomorphs after 48 h. Reaction rim microlites vary from 5-16 ?m in size, with no systematic relationship between crystal size and the duration or magnitude of heating. Time-averaged rim microlite growth rates decrease steadily with increasing experimental duration (from 3.97 ×10-7 mms-1 to 3.1 to 3.5 ×10-8 mms-1). Time-averaged microlite nucleation rates also decrease with increasing experimental duration (from 1.2 ×103mm-3s-1 to 5.3 mm-3 s-1). There is no systematic relationship between time-averaged growth or nucleation rates and the magnitude of the heating step. Ortho- and clinopyroxene together constitute 57-90 modal % mineralogy in each reaction rim. At constant temperature, clinopyroxene abundances decrease with increasing experimental duration, from 72 modal % (3 h at 900 °C) to 0% (48 h at 880 °C, and 36 h at 900 and 920 °C). Fe-Ti oxides increase from 6-12 modal % (after 3-6 h) to 26-34 modal % (after 36-48 h). Plagioclase occurs in relatively minor amounts (500 ?m from reacted amphibole) are consistent with inter-microlite rim glasses (71.3-77.7 wt.% SiO2) within a given experiment and there is a weakly positive correlation between increasing run duration and inter-microlite melt SiO2 (68.9-78.5 wt.%). Our results indicate that experimental heating-induced amphibole reaction rims have thicknesses, textures, and mineralogies consistent with many of the natural reaction rims seen at arc-andesite volcanoes. They are also texturally consistent with experimental decompression reaction rims. On this basis it may be challenging to distinguish between decompression and heating mechanisms in nature.

  18. 76 FR 69720 - NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2011-11-09

    ... From the Federal Register Online via the Government Printing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market... in the above-referenced proceeding of NaturEner Rim Rock Wind Energy, LLC's application for...

  19. Stereological evolution of the rim structure in PWR-fuels at prolonged irradiation: Dependencies with burn-up and temperature

    International Nuclear Information System (INIS)

    The stereology of the rim-structure was studied for PWR-fuels up to the ninth irradiation cycle, achieving maximum local burn-ups of 240 GWd/tM and beyond. At intermediate radial positions (0.55 0 c = 0.29. Rim-cavities are expected to remain closed at least up to this limit

  20. 76 FR 69720 - NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2011-11-09

    ...Commission [ Docket No. ER12-295-000] NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based...the above-referenced proceeding of NaturEner Rim Rock Wind Energy, LLC's application for market-based rate...

  1. Enfermedad de Paget en Chile: una serie de 15 pacientes / Paget disease of bone: Report of 15 cases

    Scientific Electronic Library Online (English)

    Gilberto, González V; Francisca, Brusco G; Eugenio, Arteaga U; José, Rodríguez P; Sergio, Jacobelli G; Loreto, Massardo V; Cristián, Ortiz M; Oscar, Contreras O.

    2003-05-01

    Full Text Available [...] Abstract in english Background: Paget disease of bone (PD) is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and m [...] ethods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained data from 15 patients with PD (ten males, eight Chilean, six European and one Asian), eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit). Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Méd Chile 2003; 131: 491-7).

  2. Enfermedad de Paget en Chile: una serie de 15 pacientes Paget disease of bone: Report of 15 cases

    Directory of Open Access Journals (Sweden)

    Gilberto González V

    2003-05-01

    Full Text Available Background: Paget disease of bone (PD is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and methods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained data from 15 patients with PD (ten males, eight Chilean, six European and one Asian, eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit. Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Méd Chile 2003; 131: 491-7.

  3. Bone pain or tenderness

    Science.gov (United States)

    ... joint pain and muscle pain . The source of bone pain may be clear, such as from a fracture following an accident. Other causes, such as cancer that spreads ( metastasizes ) to the bone, may be ...

  4. Bone marrow imaging

    International Nuclear Information System (INIS)

    Bone marrow imaging is of limited value in most patients with hematologic disorders. Frequently marrow aspirate or biopsy can reveal detailed information for accurate diagnosis. However in patients with nonuniform marrow distribution bone marrow imaging may be of considerable help in localizing the diseased sites for marrow sampling. Marrow scintigraphy in conjunction with bone imaging has been used in the evaluation of bone and joint complaints in patients with sickle cell disorders. Marrow scanning with Fe-52 has been utilized in the investigation of mass lesions that may represent extramedullary hematopoiesis. Bone marrow imaging is of limited value in the metastatic workup of patients with malignancy. This paper discusses how bone marrow scanning is useful in evaluating the distribution of active marrow in various hematologic disorders. It is also useful in evaluation of the complications of these disorders. It may be used, in conjunction with bone imaging, to aid in the differential diagnosis of bone pain in patients with predisposition to marrow infarction

  5. Metastatic Bone Disease

    Science.gov (United States)

    ... tumor. • Fractures. Weakened bones break more easily. A fracture from a minor injury is another possible sign of MBD. • Anemia. The most common sites of spread — spine, pelvis, ribs, skull, upper arm, and long bones of the ...

  6. Calcaneus (Heel Bone) Fractures

    Science.gov (United States)

    ... Right) The fracture has been reduced and the bones held in place with screws. The typical method of realigning the bone fragments and holding them in place with metal plates and screws. .org Page ( 5 ) AAOS does not endorse any ...

  7. Smoking and Bone Health

    Science.gov (United States)

    ... supported by your browser. Home Bone Basics Lifestyle Smoking and Bone Health Publication available in: PDF (61 ... Overtraining Risks for Women Oral Health Partner Resources Smoking: It’s Never Too Late to Stop (NIA)

  8. Children's bone health

    OpenAIRE

    van der Sluis, I M

    2002-01-01

    The thesis can be divided in two main parts. In the first part (Chapter 2 to 5) bone mineral density, bone metabolism and body composition in healthy children and young adults have been evaluated, while in the second part (Chapter 6 to 10) these issues were studied in children with various diseases. Healthy children were studied to gain references for parameters of bone turnover, and to extend our reference data for bone density and body composition. Furthermore, the effect of ...

  9. Aging and Bone

    OpenAIRE

    Boskey, A.L.; Coleman, R.

    2010-01-01

    Bones provide mechanical and protective function, while also serving as housing for marrow and a site for regulation of calcium ion homeostasis. The properties of bones do not remain constant with age; rather, they change throughout life, in some cases improving in function, but in others, function deteriorates. Here we review the modifications in the mechanical function and shape of bones, the bone cells, the matrix they produce, and the mineral that is deposited on this matrix, while presen...

  10. Osteocyte Signaling in Bone

    OpenAIRE

    Schaffler, Mitchell B; Kennedy, Oran D.

    2012-01-01

    Osteocytes, the cells residing within the bone matrix and comprising 90% to 95% of the all bone cells, have long been considered quiescent bystander cells compared to the osteoblasts and osteoclasts whose activities cause bone gain and loss, and whose dysfunction lead to growth defects and osteoporosis. However, recent studies show that osteocytes play a crucial, central role in regulating the dynamic nature of bone in all its diverse functions. Osteocytes are now known to be the principal se...

  11. Diffusion in Bone Tissue

    OpenAIRE

    Lindberg, Gustav

    2013-01-01

    In order to prevent or modify the processes of bone degeneration the modeling and remodeling of bone tissue must be better understood. In this thesis it is assumed that the primary condition leading to bone growth is a change of the chemical environment caused by transport of matter resulting from stress driven diffusion. The change in the chemical environment may consist of changes in the concentration of different substances stimulating, for example, bone building osteoblast ...

  12. Gracile bone dysplasias

    Energy Technology Data Exchange (ETDEWEB)

    Kozlowski, Kazimierz [Department of Medical Imaging, The Children' s Hospital at Westmead, Locked Bag 4001, Westmead 2145, NSW (Australia); Masel, John [Department of Radiology, Royal Children' s Hospital, Brisbane (Australia); Sillence, David O. [Department of Paediatrics and Child Health, The University of Sydney (Australia); Arbuckle, Susan [Department of Anatomical Pathology, The Children' s Hospital at Westmead, NSW (Australia); Juttnerova, Vera [Oddeleni Lekarske Genetiky, Hradec Kralove (Czech Republic)

    2002-09-01

    Gracile bone dysplasias constitute a group of disorders characterised by extremely slender bones with or without fractures. We report four newborns, two of whom showed multiple fractures. Two babies had osteocraniostenosis and one had features of oligohydramnios sequence. The diagnosis in the fourth newborn, which showed thin long bones and clavicles and extremely thin, poorly ossified ribs, is uncertain. Exact diagnosis of a gracile bone dysplasia is important for genetic counselling and medico-legal reasons. (orig.)

  13. Small Animal Bone Biomechanics

    OpenAIRE

    Vashishth, Deepak

    2008-01-01

    Animal models, in particular mice, offer the possibility of naturally achieving or genetically engineering a skeletal phenotype associated with disease and conducting destructive fracture tests on bone to determine the resulting change in bone’s mechanical properties. Several recent developments, including nano- and micro- indentation testing, microtensile and microcompressive testing, and bending tests on notched whole bone specimens, offer the possibility to mechanically probe small animal ...

  14. Temporal Bone Meningiomas

    OpenAIRE

    Vrionis, Fotios D.; Robertson, Jon H.; Gardner, Gale; Heilman, Carl B.

    1999-01-01

    Meningiomas involving the temporal bone may originate from arachnoid cell nests present within the temporal bone (intratemporal), but more frequently originate from arachnoid cell nests of the posterior or middle cranial fossa with secondary invasion of the TB (extratemporal). In this study, we retrospectively reviewed the charts of 13 patients with meningiomas involving the temporal bone who underwent surgery. Tumors of the posterior fossa with only temporal bone hyperostosis, but without in...

  15. Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions

    International Nuclear Information System (INIS)

    Aim: The aim of this study is to evaluate the value of the apparent diffusion coefficient (ADC) obtained in diffusion-weighted (DW) MR sequences for the differentiation between malignant and benign bone marrow lesions. Method: Forty-five patients with altered signal intensity vertebral bodies on conventional MR sequences were included. The cause of altered signal intensity was benign osteoporotic collapse in 16, acute neoplastic infiltration in 15, and infectious processes in 14; based on plain-film, CT, bone scintigraphy, conventional MR studies, biopsy or follow-up. All patients underwent isotropic DW MR images (multi-shot EPI, b values of 0 and 500 s/mm2). Signal intensity at DW MR images was evaluated and ADC values were calculated and compared between malignancy, benign edema and infectious spondylitis. Results: Acute malignant fractures were hyperintense compared to normal vertebral bodies on the diffusion-weighted sequence, except in one patient with sclerotic metastases. Mean ADC value from benign edema (1.9 ± 0.39 x 10-3 mm2/s) was significantly (p -3 mm2/s). Mean ADC value of infectious spondilytis (0.96 ± 0.49 x 10-3 mm2/s) was not statistically (p > 0.05) different from untreated metastasic lesions. ADC value was low (0.75 x 10-3 mm2/s) in one case of subacute benign fracture. Conclusions: ADC values are a useful complementary tool to characterize bone marrow lesions, in order to distinguish acute benign fractures from malignant or infectious bone lesions. However, ADC values are not valuable in order to differentiate malignancy from infection.

  16. Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions

    Energy Technology Data Exchange (ETDEWEB)

    Balliu, E. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: eballiu@gmail.com; Vilanova, J.C. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: Kvilanova@comg.es; Pelaez, I. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: isapelaezrx@yahoo.es; Puig, J. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: jpuigalcantara@yahoo.es; Remollo, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sremollo@gmail.com; Barcelo, C. [Department of Computer Science and Applied Mathematics, University of Girona (Spain)], E-mail: carles.barcelo@udg.es; Barcelo, J. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: rmgirona@comg.es; Pedraza, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sapedraza@gmail.com

    2009-03-15

    Aim: The aim of this study is to evaluate the value of the apparent diffusion coefficient (ADC) obtained in diffusion-weighted (DW) MR sequences for the differentiation between malignant and benign bone marrow lesions. Method: Forty-five patients with altered signal intensity vertebral bodies on conventional MR sequences were included. The cause of altered signal intensity was benign osteoporotic collapse in 16, acute neoplastic infiltration in 15, and infectious processes in 14; based on plain-film, CT, bone scintigraphy, conventional MR studies, biopsy or follow-up. All patients underwent isotropic DW MR images (multi-shot EPI, b values of 0 and 500 s/mm{sup 2}). Signal intensity at DW MR images was evaluated and ADC values were calculated and compared between malignancy, benign edema and infectious spondylitis. Results: Acute malignant fractures were hyperintense compared to normal vertebral bodies on the diffusion-weighted sequence, except in one patient with sclerotic metastases. Mean ADC value from benign edema (1.9 {+-} 0.39 x 10{sup -3} mm{sup 2}/s) was significantly (p < 0.0001) higher than untreated metastasic lesions (0.9 {+-} 1.3 x 10{sup -3} mm{sup 2}/s). Mean ADC value of infectious spondilytis (0.96 {+-} 0.49 x 10{sup -3} mm{sup 2}/s) was not statistically (p > 0.05) different from untreated metastasic lesions. ADC value was low (0.75 x 10{sup -3} mm{sup 2}/s) in one case of subacute benign fracture. Conclusions: ADC values are a useful complementary tool to characterize bone marrow lesions, in order to distinguish acute benign fractures from malignant or infectious bone lesions. However, ADC values are not valuable in order to differentiate malignancy from infection.

  17. Facts about Broken Bones

    Science.gov (United States)

    ... be able to tell that they broke a bone! Breaking a bone is a big shock to your whole body. ... suggest you do special exercises to improve your strength and flexibility. ... don't break any more bones? Accidents happen, but you’ll stay safer when ...

  18. Bone mineral density test

    Science.gov (United States)

    BMD test; Bone density test; Bone densitometry; DEXA scan; DXA; Dual-energy x-ray absorptiometry; p-DEXA; Osteoporosis-BMD ... Bone density testing can be done several ways. The most common and accurate way uses a dual-energy x- ...

  19. What's a Funny Bone?

    Science.gov (United States)

    ... the Body Works Main Page What's a Funny Bone? KidsHealth > Kids > Q&A > Q&A > What's a Funny Bone? Print A A A Text Size Have you ... prickly kind of dull pain? That's your funny bone! It doesn't really hurt as much as ...

  20. Incident laser modulation of a repaired damage site with a rim in fused silica rear subsurface

    International Nuclear Information System (INIS)

    Local CO2 laser treatment has proved to be an effective method to prevent the 351-nm laser-induced damage sites in a fused silica surface from exponentially growing, which is responsible for limiting the lifetime of optics in high fluence laser systems. However, the CO2 laser induced ablation crater is often surrounded by a raised rim at the edge, which can also result in the intensification of transmitted ultraviolet light that may damage the downstream optics. In this work, the three-dimensional finite-difference time-domain method is developed to simulate the distribution of electrical field intensity in the vicinity of the CO2 laser mitigated damage site located in the exit subsurface of fused silica. The simulated results show that the repaired damage sites with raised rims cause more notable modulation to the incident laser than those without rims. Specifically, we present a theoretical model of using dimpled patterning to control the rim structure around the edge of repaired damage sites to avoid damage to downstream optics. The calculated results accord well with previous experimental results and the underlying physical mechanism is analysed in detail. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  1. RIMS/sup tm/ - radiological information management system: software package EI-029-S86

    Energy Technology Data Exchange (ETDEWEB)

    1988-01-01

    RIMS/sup tm/ has been developed for health physics record keeping and reporting. It provides for the management needs relating to radiological information control at a nuclear facility. The program is comprised of the following modules: Personnel Radiological Information, Radiological Work Permit, Radiation Survey Records, Access Control, ALARA Reporting, and Respirator and Survey Instrument Inventory Modules.

  2. RIMS/sup tm/ - radiological information management system: software package EI-029-S86

    International Nuclear Information System (INIS)

    RIMS/sup tm/ has been developed for health physics record keeping and reporting. It provides for the management needs relating to radiological information control at a nuclear facility. The program is comprised of the following modules: Personnel Radiological Information, Radiological Work Permit, Radiation Survey Records, Access Control, ALARA Reporting, and Respirator and Survey Instrument Inventory Modules

  3. Fleeting Amyloid-like Forms of Rim4 Ensure Meiotic Fidelity.

    Science.gov (United States)

    Ford, Alice Flynn; Shorter, James

    2015-10-01

    Berchowitz et al. establish that transient amyloid-like forms of Rim4, a yeast RNA-binding protein with a predicted prion domain, translationally repress cyclin CLB3 in meiosis I, thereby ensuring homologous chromosome segregation. These findings suggest that prion domains might enable formation of tightly regulated amyloid-like effectors in diverse functional settings. PMID:26451477

  4. Effect of centrifugal load on crack path in thin-rimmed and webbed gears

    Directory of Open Access Journals (Sweden)

    F. Curà

    2015-10-01

    Full Text Available Thin rimmed and webbed gears are used in particular applications to reduce systems weight. This kind of gears need an accurate and fail safe design. As a matter of fact, a possible failure, due to bending fatigue, consists in crack nucleation and consequent growth, in particular in the tooth root zone. These cracks may propagate through the tooth or through the rim. Crack propagation direction is basically influenced by the wheel geometry parameters, above all the rim thickness. Studies available in literature emphasize three ranges for the backup ratio values, involving different behaviors. These ranges are related to the crack propagation paths; respectively through the tooth, through the rim and in an unforeseeable way. This last uncertainty zone depends on other parameters, related to both geometry and loading conditions. In this work the effect of wheel speed related to the bending load has been investigated. The investigation has been carried out by means of numerical models involving both 2D finite element and extended finite element models (XFEM. Results shows that both crack initiation point and crack propagation path are strongly influenced by centrifugal load; this effect is mainly evident in the uncertainty zone of the backup ratio

  5. TEMPERATURE TOLERANCE OF RED-RIMMED MELANIA MELANOIDES TUBERCUATA, (GASTROPODA: PROSOBRANCHIA: THIARIDAE)

    Science.gov (United States)

    The red-rimmed melania Melanoides tuberculata is an exotic aquatic snail of the family Thiaridae that is spreading across the southern United States and in geothermal waters in several midwestern and northwestern states. In addition to its potential to displace native mollusks it is known to harbor...

  6. Constraints on the height of the inner disk rim in pre-main-sequence stars

    CERN Document Server

    Vinkovi?, Dejan

    2014-01-01

    The structure of inner region of protoplanetary disks around young pre-main-sequence stars is still poorly understood. This part of the disk is shaped by various forces influencing dust and gas dynamics and by dust sublimation, which creates abrupt drops in the dust density. This region also emits a strong near-infrared excess that cannot be explained by classical accretion disk models, which suggests the existence of some unusual dust distribution or disk shape. The most prevalent explanation to date is the puffed-up inner disk rim model, where the disk exhibits an optically thin cavity around the star up to the distance of dust sublimation. The critical parameter in this model is the inner disk rim height $z_{\\rm max}$ relative to the rim's distance from the star $R_{\\rm in}$. Observations often require $z_{\\rm max}/R_{\\rm in}\\gtrsim0.2$ to reproduce the near-infrared excess in the spectra. In this paper we put together a comprehensive list of processes that can shape the inner disk rim and combined them to...

  7. Manned Mars Mission Exploration Zone: Eastern Rim of Hellas Impact Basin

    Science.gov (United States)

    Rice, J. W.; Crown, D. A.; Feldman, W. C.; Pathare, A. V.; Feustel, A. J.; Gertsch, L. S.

    2015-10-01

    Our proposed 200 km diameter Exploration Zone centered near 40°S; 104°E is located along the eastern rim of the Hellas basin which will allow astronauts to study and collect very ancient deep seated materials which were excavated in the impact event.

  8. Study on High Sensitive FFDL Technique for Monju and next generation SFR Using RIMS

    International Nuclear Information System (INIS)

    The high sensitive Failed Fuel Detection and Location technique for fast reactors has been developed using RIMS. Major achievements: - Tag gas (krypton and Xenon) was successfully identified with no concentration process in Joyo. - Burn-up of the failed fuel subassembly can be assumed. - Prototype FFDL system for Monju was proposed. ? Further enhancement of fast reactor safety

  9. Single stage reconstruction of alar rim defect using auricular composite graft: a case report

    Directory of Open Access Journals (Sweden)

    Soni A

    2005-01-01

    Full Text Available A case report of reconstruction of a post infective alar rim defect, in a girl of 13 years of age, occurring as a result of septic piercing of the nose, using a composite graft taken from the ear in a single stage is described.

  10. Usefulness of 18F fluoride PET/CT in breast cancer patients with osteosclerotic bone metastases

    International Nuclear Information System (INIS)

    Bone metastasis is an important factor for the treatment and prognosis of breast cancer patients. Whole body bone scintigraphy (WBBS) can evaluate skeletal metastases, and 18F FDG PET/CT seems to exhibit high specificity and accuracy in detecting bone metastases. However, there is a limitation of 18F FDG PET in assessing sclerotic bone metastases because some lesions may be undetectable. Recent studies showed that 18F fluoride PET/CT is more sensitive than WBBS in detecting bone metastases. This study aims to evaluate the usefulness of 18F fluoride PET/CT by comparing it with WBBS and 18F FDG PET/CT in breast cancer patients with osteosclerotic skeletal metastases. Nine breast cancer patients with suspected bone metastases (9 females; mean age ± SD, 55.6±10.0 years) underwent 99mTc MDP WBBS, 18F FDG PET/CT and 18F fluoride PET/CT. Lesion based analysis of five regions of the skeletons(skull, vertebral column, thoracic cage, pelvic bones and long bones of extremities) and patient based analysis were performed. 18F fluoride PET/CT, 18F FDG PET/CT and WBBS detected 49, 20 and 25 true metastases, respectively. Sensitivity, specificity, positive predictive value and negative predictive value of 18F fluoride PET/CT were 94.2%, 46.3%, 57.7% and 91.2%, respectively. Most true metastatic lesions of 18F fluoride PET/CT had osteosclerotic change (45/49, 91.8%), and only four lesions showed osteolytic change. Most lesions on 18F FDG PET/CT also demonstrated osteosclerotic change (17/20, 85.0%) with three osteolytic lesions. All true metastatic lesions detected on WBBS and 18F FDG PET/CT were identified on 18F fluoride PET/CT. 18F FDG PET/CT in detecting osteosclerotic metastatic lesions. 18F fluoride PET/CT might be useful in evaluating osteosclerotic metastases in breast cancer patients

  11. The kinetics of dolomite reaction rim growth under isostatic and non-isostatic pressure conditions

    Science.gov (United States)

    Helpa, V.; Rybacki, E.; Morales, L. G.; Abart, R.; Dresen, G. H.

    2013-12-01

    During burial and exhumation, rocks are simultaneously exposed to metamorphic reactions and tectonic stresses. Therefore, the reaction rate of newly formed minerals may depend on chemical and mechanical driving forces. Here, we investigate the reaction kinetics of dolomite (CaMg[CO3]2) rim growth by solid-state reactions experiments on oriented calcite (CaCO3) and magnesite (MgCO3) single crystals under isostatic and non-isostatic pressure conditions. Cylindrical samples of 3-5 mm length and 7 mm diameter were drilled and polished perpendicular to the rhombohedral cleavage planes of natural clear crystals. The tests were performed using a Paterson-type deformation apparatus at P = 400 MPa confining pressure, temperatures, T, between 750 and 850°C, and reaction durations, t, of 2 - 146 h to calculate the kinetic parameters of dolomite rim growth under isostatic stress conditions. For non-isostatic reaction experiments we applied in addition differential stresses, ?, up to 40 MPa perpendicular to the contact interface at T = 750°C for 4 - 171 h duration, initiating minor inelastic deformation of calcite. The thickness of the resulting dolomite reaction rims increases linearly with the square root of time, indicating a diffusion-controlled reaction. The rims consist of two different textural domains. Granular dolomite grains (? 2 -5 ?m grain size) form next to calcite and elongated palisade-shaped grains (1-6 ?m diameter) grow perpendicular to the magnesite interface. Texture measurements with the electron backscatter diffraction technique indicate that the orientations of dolomite grains are mainly influenced by the orientation of the calcite educt crystal, in particular in the granular rim. To some extent, the texture of dolomite palisades is also influenced by the orientation of magnesite. The thickness of the two individual layers increases with temperature. At 400 MPa isostatic pressure, T = 750°C and t = 29 hours, a 5 ?m thick granular dolomite layer and a 7 ?m thick palisade-shaped layer evolve. At similar conditions and a differential stress of 30 MPa, the rim thickness remains similar; consequently the effect of non-isostatic stress on dolomite rim growth is negligible. Platinum markers show that the initial calcite-magnesite interface is located between granular and palisade-forming dolomite, indicating that rim growth occurs by counter diffusion of MgO and CaO. Diffusion of MgO across the dolomite reaction rim into calcite forms additionally magnesio-calcite grains with diameters of ? 13 - 46 ?m, depending on the experimental conditions and increasing with increasing distance to the dolomite boundary. At T = 750°C, t = 29 hours, the thickness of the magnesio-calcite layer is 32 ?m (isostatic) - 35 ?m (? = 30 MPa). The experiments indicate that solid-state reaction rim growth of dolomite between calcite and magnesite is primarily controlled by diffusion of MgO and CaO, forming layers with different microstructures during growth into the educt phases. The kinetics of the reaction in the carbonate system are not significantly changed by differential stresses up to 40 MPa. We suggest that volume diffusion is the dominant transport mechanism, which is presumably less affected by non-isostatic stresses than grain boundary diffusion.

  12. Reaction rim growth in the systems MgO-SiO2 and CaO-MgO-SiO2: Diffusion pathways and the effect of water

    OpenAIRE

    Joachim, Bastian

    2011-01-01

    Growth of reaction rims and metamorphic coronas is recorded in many metamorphic rocks. Various parameters such as pressure, temperature, time, the chemical composition of a system and the presence of fluids may affect reaction rim growth. Laboratory experiments are the method of choice to derive transport mechanisms, reaction rates and component mobilities in polycrystalline rims as a function of these parameters. The major goal of this study is to derive component mobilities in rim growth ex...

  13. Iron-Manganese Redox Reactions in Endeavour Crater Rim Apron Rocks

    Science.gov (United States)

    Ming, D. W.; Mittlefehldt, D. W.; Gellert, R.; Peretyazhko, T.; Clark, B. C.; Morris, R. V.; Yen, A. S.; Arvidson, R. E.; Crumpler, L. S.; Farrand, W. H.; Grant, J. A., III; Jolliff, B. L.; Parker, T. J.; Schroder, C.

    2015-01-01

    The Mars Exploration Rover Opportunity has been exploring Noachian age rocks and outcrops on the rim of the 22 km diameter Endeavour crater since August 2011. The Cape York area is a low-lying rim of Endeavour that contains 3 distinct lithologies: 1) the stratigraphically lowest Matijevic fm of pre-impact lithology, 2) Shoemaker fm of impact breccias, and 3) the stratigraphically highest rim lithology Grasberg fm of post-impact sediments that drape the lower slopes of the rim. The sulfate-rich sediment of the Burns fm lies unconformably over the Grasberg fm. Ca-sulfate veins were discovered in Grasberg fm sediments; the sulfates precipitated from aqueous fluids flowing upward through these materials. Opportunity investigated the chemistry and morphology of outcrops in the Matijevic fm that have Fe(sup 3+)-rich smectite detected by orbital signatures returned by CRISM on MRO. Matijevic fm also contains "boxwork" fractures with chemistry consistent with an Al-rich smectite and veins that appear to be rich in Ca-sulfate. More recently on Cape Tribulation, Opportunity has characterized two S-, Mg- and Mn-rich rich rocks overturned and fractured by the rover's wheels on Cook Haven. Those rocks have been dubbed "Pinnacle Island" and "Stuart Island" and will be referred to as the "Island" rocks. The objectives of this study are to characterize the Fe and Mn contents in the Cape York materials, including the two Island rocks, and to provide a model for Mn mobilization and precipitation. Detailed geochemistry of Endeavour rim rocks is presented in a companion paper. Geochemical trends and elemental associations were obtained from data returned by the Alpha Particle X-ray Spectrometer (APXS) on Opportunity.

  14. Recent studies on the formation of the rim structure and on polygonization in LWR fuel

    International Nuclear Information System (INIS)

    At cross sectional burnups in excess of - 40 MWd/kgUO2, a grain subdivision process occurs at the outer rim of LWR UO2 fuel. A similar phenomenon can be observed in the Pu-rich inclusions in MOX fuel. Three phenomena are usually observed in the resulting 'Rim zone': formation of small grains of sub?m size, formation of pores of about ?m size, and reduction of the signal of fission Xe in EPMA measurements. The mechanisms for rim-structure formation are still not fully understood, and it is not completely obvious, whether the above three processes occur simultaneously or one after the other in sequential steps. Also, two different types of small grains have recently been found at CEA in France.The present state of knowledge on rim structure formation in LWR fuel is reviewed, as well as recent progress in observing and understanding the formation of nanocrystals and of polygonization in other ceramics. Controlled ion irradiation techniques, including fission product ions at fission energy (e.g. 72 MeV iodine ions) have been applied to UO2 and to simulated high burnup UO2, so-called SIMFUEL. The process of polygonization, i.e. the rearrangement of dislocations into dislocation walls forming low energy 'sub-boundaries' and rather perfect, but slightly misoriented subgrains, was studied in these experiments. The same experiments confirmed the extreme radiation stability of UO2 and demonstrated effects of fission spikes: fission-induced bubble formation, re-solution of fission gases from bubbles and fission-enhanced gas diffusion and release. No temperature dependence was found between room temperature and 500 deg. C. The combined results are used to discuss possible mechanisms for polygonization and rim structure formation in UO2. (author)

  15. [Bone metabolism: molecular mechanisms].

    Science.gov (United States)

    Neumann, E; Schett, G

    2007-07-01

    In order to accommodate individual load, the skeletal system is in a continual state of change. Bone metabolism guarantees optimal bone structure. The osteoblasts are responsible for the synthesis and the osteoclasts for resorption of the bone. A finely adjusted interplay between molecular mechanisms leads, via cytokines, hormones and growth factors, to an homeostasis in bone metabolism. Disturbances of this process lead via increased bone resorption to osteoporosis, and via increased synthesis to osteopetrosis. This contribution describes the known molecular mechanisms in this remodelling process. PMID:17562055

  16. Tin in Human Bones

    OpenAIRE

    Jambor, Jaroslav; Smreka, Vâclav

    1993-01-01

    TIN IN HUMAN BONES. The tin content in the bones of 149 skeletons from the 1st - 5th centuries A.D., and of 11 individuals of the recent population was determined. The bone samples were carbonized and analyzed through emission spectroscopy with a.c. excitation. The tin content in bones of recent populations not exposed to extra tin supply is about one order of magnitude higher than is the case with the bones od some populations that lived at the beginning of our era. The distribut...

  17. Monostotic Paget Disease of Bone or Bone Metastasis?

    OpenAIRE

    Özlem Erdem Süer; Jale Meray; Nesrin Demirsoy; Zelal Kele?

    2008-01-01

    Paget’s disease of bone is a metabolic bone disorder with male predominance and characterized by increased bone turnover. Recent literature indicates a reduction in incidence and severity. We report a 55 years old female patient who was admitted with knee pain, and whose pelvis x-ray demonstrated pathological features. She was investigated with preliminary diagnoses of Paget’s disease of bone, osteosclerotic bone metastasis and primary bone tumor. Histopathological examination of bone biopsy ...

  18. Nanomaterials and bone regeneration

    Science.gov (United States)

    Gong, Tao; Xie, Jing; Liao, Jinfeng; Zhang, Tao; Lin, Shiyu; Lin, Yunfeng

    2015-01-01

    The worldwide incidence of bone disorders and conditions has been increasing. Bone is a nanomaterials composed of organic (mainly collagen) and inorganic (mainly nano-hydroxyapatite) components, with a hierarchical structure ranging from nanoscale to macroscale. In consideration of the serious limitation in traditional therapies, nanomaterials provide some new strategy in bone regeneration. Nanostructured scaffolds provide a closer structural support approximation to native bone architecture for the cells and regulate cell proliferation, differentiation, and migration, which results in the formation of functional tissues. In this article, we focused on reviewing the classification and design of nanostructured materials and nanocarrier materials for bone regeneration, their cell interaction properties, and their application in bone tissue engineering and regeneration. Furthermore, some new challenges about the future research on the application of nanomaterials for bone regeneration are described in the conclusion and perspectives part. PMID:26558141

  19. Bone stress injuries

    International Nuclear Information System (INIS)

    Bone stress injuries are due to cyclical overuse of the bone. They are relatively common in athletes and military recruits but also among otherwise healthy people who have recently started new or intensive physical activity. Diagnosis of bone stress injuries is based on the patient's history of increased physical activity and on imaging findings. The general symptom of a bone stress injury is stress-related pain. Bone stress injuries are difficult to diagnose based only on a clinical examination because the clinical symptoms may vary depending on the phase of the pathophysiological spectrum in the bone stress injury. Imaging studies are needed to ensure an early and exact diagnosis, because if the diagnosis is not delayed most bone stress injuries heal well without complications

  20. [Bone and Nutrition. Bone and phosphorus intake].

    Science.gov (United States)

    Arai, Hidekazu; Sakuma, Masae

    2015-07-01

    Phosphorus is necessary for bone mineralization. Although adequate phosphorus intake is essential for skeletal mineralization, it is reported that excessive phosphorus intake can induce deleterious effect on bone. Recently, since the Japanese diet has been westernized, phosphorus intake by the meat and dairy products has increased. Furthermore, along with the development of processed foods, excessive intake of inorganic phosphorus from food additives has become a problem. An adverse effect on parathyroid hormone (PTH) secretion from high phosphorus intake was seen only when calcium intake was inadequate. Dietary calcium to phosphorus ratio can be considered as one of the indicators that can predict the health of the bone. PMID:26119308

  1. Monostotic Paget Disease of Bone or Bone Metastasis?

    Directory of Open Access Journals (Sweden)

    Özlem Erdem Süer

    2008-06-01

    Full Text Available Paget’s disease of bone is a metabolic bone disorder with male predominance and characterized by increased bone turnover. Recent literature indicates a reduction in incidence and severity. We report a 55 years old female patient who was admitted with knee pain, and whose pelvis x-ray demonstrated pathological features. She was investigated with preliminary diagnoses of Paget’s disease of bone, osteosclerotic bone metastasis and primary bone tumor. Histopathological examination of bone biopsy confirmed Paget’s disease of bone and Paget’s disease of bone is reviewed. Turk J Phys Med Rehab 2008;54:73-6

  2. [Bone and Nutrition. Sclerostin and bone metabolism].

    Science.gov (United States)

    Tatsumi, Sawako; Nagamoto, Kenta; Ogata, Mao; Miyamoto, Ken-ichi

    2015-07-01

    Osteocytes orchestrate bone resorption and bone formation by controlling osteoclast and osteoblast activity. On the other hand, osteocytes secret FGF23 (fibroblast growth factor 23), FGF23 acts on the kidney to control phosphate homeostasis. Sclerostin is also released from osteocytes and it regulated osteoblast activity through Wnt/?-catenin pathway. Therefore, an antibody that targets sclerostin is currently in phase- III clinical trials for the treatment of osteoporosis and it is expected as new therapeutics. PMID:26119318

  3. Bone health in adolescence

    Directory of Open Access Journals (Sweden)

    Oya

    2011-03-01

    Full Text Available The skeleton undergoes rapid change with respect to growth, modeling and remodeling processes in adolescence. Consequently, the effects of factors that affect bone health positively or negatively can be greater. Between 40% and 60% of, peak bone mass which serves as the bone bank for life, is accrued during adolescence. Lifetime risk of osteoporosis and fracture may be increased if optimal peak bone mass cannot be reached.Accrual of peak bone mass is affected by unmodifiable intrinsic factors and less important extrinsic factors. Higher body mass index and body fat and lower dietary calcium intake increase fracture risk in healthy adolescents. Bone mass was found to be 5% to 10% lower in adolescents with fracture than their peers. Adequate nutrition in amount and composition and life style factors are important for skeletal health. While diets rich in saturated fats and refined sugars and lower in protein may be detrimental to bone health, optimal quantities of polyunsaturated fatty acids and complex carbohydrates may be beneficial to bone health. Dietary calcium and vitamin D are key factors in promoting bone health and preventing bone loss. Phosphorus and magnesium as well as other elements and especially vitamin C and K have been shown to play important roles in bone health. While weight bearing regular exercise and a healthy bodyweight are beneficial to bone health, alcohol consumption and smoking contribute to poor bone health. Adolescence may serve as a period of opportunity for reduction of the incidence of osteoporosis in adulthood through implication of effective intervention strategies. (Turk Arch Ped 2011; 46 Suppl: 54-8

  4. Comparison between 18F-NaF PET and PET-CT to detect bone metastases in patients with lung cancer

    International Nuclear Information System (INIS)

    Objective: To evaluate the effect of 18F-sodium fluoride (18F-NaF) PET-CT in the detection of bone metastases in patients with lung cancer. Methods: Thirty-four patients with newly diagnosed lung cancer were performed with 18F-NaF PET-CT. 18F-NaF PET and 18F-NaF PET-CT were interpreted separately. Lesions were categorized as malignant, benign or inconclusive. A panel of reference methods was used, including MRI (34 patients), 18F-fluorodeoxyglucose PET-CT (4 patients), histopathology (2 patients), or clinical follow-up of at least 6 months (6 patients). Results: In patient-based analysis, 11 of 34 patients had bone metastases. 18F-NaF PET-CT correctly diagnosed all 11 patients with bone metastases, 18F-NaF PET only correctly detected 8 of them. 18F-NaF PET-CT had no false and inconclusive diagnosis. In lesion-based analysis, 118 lesions were assessed which had final diagnosis (47 metastases, 71 benign lesions). 18F-NaF PET-CT was correct in 46 metastatic lesions and 71 benign lesions, but false-negative in lesion. 18F-NaF PET was correct in 27 metastatic lesions and 64 benign lesions, but wrong in 3 lesions (2 benign lesions, 1 metastatic lesions), and equivocal in 24 lesions. Based on the corresponding appearance on low-dose CT, 46 of 47 lesions were categorized metastases (31 presented as sites of increased uptake with corresponding lytic or sclerotic changes, and other 15 metastases show normal or non-specific appearing bone), only 1 sclerotic metastasis was judged benign. All 71 benign lesions have a benign appearance on low-dose CT. In patient- based analysis, categorizing equivocal and malignant interpretation as suggestive for malignancy, the 18F-NaF PET-CT was more specific than 18F-NaF PET (100% vs 78%, ?2=10.78, P18F PET-CT was more sensitive than 18F-NaF PET (100% vs 73%, 22=6.41, P2=2.03, P>0.05 ). In lesion-based analysis, the similar results were obtained as patient-based analysis. Conclusion: 18F-NaF PET-CT was both sensitive and specific for detection of bone metastases in patients with newly diagnosed lung cancer. With the diagnosis information of low-dose CT, its ability of differentiation between malignant and benign lesions is improved. (authors)

  5. Biomaterials and bone mechanotransduction

    Science.gov (United States)

    Sikavitsas, V. I.; Temenoff, J. S.; Mikos, A. G.; McIntire, L. V. (Principal Investigator)

    2001-01-01

    Bone is an extremely complex tissue that provides many essential functions in the body. Bone tissue engineering holds great promise in providing strategies that will result in complete regeneration of bone and restoration of its function. Currently, such strategies include the transplantation of highly porous scaffolds seeded with cells. Prior to transplantation the seeded cells are cultured in vitro in order for the cells to proliferate, differentiate and generate extracellular matrix. Factors that can affect cellular function include the cell-biomaterial interaction, as well as the biochemical and the mechanical environment. To optimize culture conditions, good understanding of these parameters is necessary. The new developments in bone biology, bone cell mechanotransduction, and cell-surface interactions are reviewed here to demonstrate that bone mechanotransduction is strongly influenced by the biomaterial properties.

  6. Bone tumors: Nursing care

    International Nuclear Information System (INIS)

    Bone tumors represent approximately 5% of childhood malignancies. osteosarcoma is the primary malignant bone tumor, accounting for 60% of cancer with peak incidence in the 2nd decade of life. Ewing's sarcoma is the second most common bone cancer with peak at a slightly younger age. This presentation discusses similarities and differences in the diagnosis and treatment of these two malignancies. Diagnostic procedures include plain radiographs, CT and MRI of the primary site, plain x-ray and CT of the chest, bone scan, and biopsy of the primary tumor. For patients diagnosed with Ewing's sarcoma, a bone marrow aspirate and biopsy will also be required. Our current approach to the treatment of bone tumors includes preoperative combination chemotherapy and en bloc surgical removal of the tumor followed by postoperative chemotherapy. In the case of Ewing's sarcoma, radiation therapy may be employed in addition to surgery, if margins are questionable of instead of surgery, if the tumor is not resectable

  7. Asia/Pacific Rim renewable energy market assessments by the State of Hawaii

    International Nuclear Information System (INIS)

    The State of Hawaii has begun to encourage its economic growth and diversification by increasing the export of U.S. energy, environment, ocean, and information technologies. Hawaii's Strategic Technology Market Assessment and Development (STMAD) program promotes the transfer of U.S. technology into Asia and the Pacific Rim, locations having phenomenal growth potential and vast technological infrastructure demands. The STMAD program is managed by the State's Department of Business, Economic Development and Tourism (DBEDT). Under the auspices of STMAD, the Hawaii Natural Energy Institute (HNEI) of the University of Hawaii is assessing biomass energy resources of Asian and Pacific Rim countries to identify and investigate sustainable energy markets. This paper reviews the STMAD program and reports findings of renewable energy assessment performed by HNEI and DBEDT. (author)

  8. Theoretical and experimental research of hammer forging process of RIM from AZ31 magnesium alloy

    Directory of Open Access Journals (Sweden)

    A. Gontarz

    2014-10-01

    Full Text Available The results of theoretical analysis and experimental tests of hammer forging process of rim part from AZ31 magnesium alloy are presented in this paper. On the basis of numerical simulation results, the analysis of limiting phenomena was made. These phenomena include: possibility of overlapping presence, not filling of die impression, overheating of material and cracks. The results of theoretical analysis provided the support for planning of experimental tests in industrial conditions. Forging tests were conducted in one of Polish forming plants, applying steam-air hammer of blow energy 63 kJ. On the basis of experimental verification, it was stated that it is possible to obtain rim forging from AZ31 alloy of assumed quality in the hammer forging process.

  9. Raman spectroscopic characterization of the core-rim structure in reaction bonded boron carbide ceramics

    International Nuclear Information System (INIS)

    Raman spectroscopy was used to characterize the microstructure of reaction bonded boron carbide ceramics. Compositional and structural gradation in the silicon-doped boron carbide phase (rim), which develops around the parent boron carbide region (core) due to the reaction between silicon and boron carbide, was evaluated using changes in Raman peak position and intensity. Peak shifting and intensity variation from the core to the rim region was attributed to changes in the boron carbide crystal structure based on experimental Raman observations and ab initio calculations reported in literature. The results were consistent with compositional analysis determined by energy dispersive spectroscopy. The Raman analysis revealed the substitution of silicon atoms first into the linear 3-atom chain, and then into icosahedral units of the boron carbide structure. Thus, micro-Raman spectroscopy provided a non-destructive means of identifying the preferential positions of Si atoms in the boron carbide lattice

  10. Iatrogenic fracture of the superomedial orbital rim during frontal trephine irrigation.

    Science.gov (United States)

    Angel, Douglas; Zener, Rebecca; Rotenberg, Brian W

    2014-12-01

    Frontal sinus trephination (FST) has numerous applications in the treatment of acute and chronic sinus disease. This procedure involves making an incision at the medial aspect of the supraorbital rim and then drilling the sinus's anterior table. Placement of a frontal trephine allows for irrigation of the frontal recess in order to evacuate the frontal sinus in a minimally invasive manner. Orbital injury is a rare complication of FST. We present a case of previously unreported orbital compartment syndrome secondary to iatrogenic fracture of the superomedial orbital rim as a complication of frontal trephine irrigation. We also review the literature on the applications of FST and its associated complications, and we discuss orbital compartment syndrome as a complication of sinus surgery. PMID:25531843

  11. Dorsal acetabular rim radiographic view for evaluation of the canine hip

    International Nuclear Information System (INIS)

    A dorsal acetabular rim (DAR) radiographic view and positioning was devised to visualize the weight-bearing of the acetabulum of dogs for hip evaluation. The DAR view was performed on 250 dogs including 38 breeds. Both males and females were evaluated; ages ranged from six weeks to 11 years. The value of this technique is to evaluate the dorsal rim of the acetabulum for damage and secondary osteoarthritic changes, to correlate palpation of joint capsule laxity and crepitation with the radiographic appearance, to show acetabular filling, and to have an objective reproducible tool for determining whether a hip is normal, dysplastic or injured. This view is recommended as part of the routine procedure for hip examination

  12. Performance improvement of the RIMS device for application to FFDL system of the fast reactor

    International Nuclear Information System (INIS)

    In the fast reactors, it's crucial to install an effective failed fuel detection and location (FFDL) system for the purpose of protecting workers from radiation exposure and reducing radiation contamination. A new type of FFDL technique focused on the gas tagging method has been proposed by using resonance ionization mass spectrometry (RIMS) for the isotope analysis of the Ar cover gas. Though precise analysis of ppt level Kr and Xe in Ar needed is difficult because of the Ar+ and Ar2+ ions generated by the photoelectron, we could successfully decrease the signal amount of these ions by applying an electrode with a slit-type hole to permit ppt level detection of 80Kr without any obvious Ar2 interference. Some promising methods concerning effective utilization of laser light are also presented to increase the photoionization efficiency for further reliability improvement of RIMS in the FFDL system. (author)

  13. Star Formation in Bright Rimmed Clouds. I. Millimeter and Submillimeter Molecular Line Surveys

    OpenAIRE

    De Vries, Christopher H.; Narayanan, Gopal; Snell, Ronald L.

    2002-01-01

    We present the results of the first detailed millimeter and submillimeter molecular line survey of bright rimmed clouds, observed at FCRAO in the CO (J=1-0), C18O (J=1-0), HCO+ (J=1-0), H13CO+ (J=1-0), and N2H+ (J=1-0) transitions, and at the HHT in the CO (J=2-1), HCO+ (J=3-2), HCO+ (J=4-3), H13CO+ (J=3-2), and H13CO+ (J=4-3) molecular line transitions. The source list is composed of a selection of bright rimmed clouds from the catalog of such objects compiled by Sugitani e...

  14. Development of SFR Research and Integration Management System (S-RIMS)

    International Nuclear Information System (INIS)

    Up to the present, the management of research and development (R and D) for a sodium cooled fast reactor (SFR) could be individually performed on each project without an organic relationship. However, a more systemic and effective integrated management of a project is required because the research and development environment is currently changing. Thus, we developed a Research and Integration Management System for SFR (S-RIMS) based on the enterprise project management (EPM) solution. The functional goals of the S-RIMS are as follows: 1. Provide data that show the progress and status of a project 2. Manage the design process and R and D products 3. Share the consistent design data between sub-projects

  15. Distribution of skeletal muscle involvement in distal myopathy with rimmed vacuoles

    International Nuclear Information System (INIS)

    Distribution of skeletal muscle involvement was studied clinically and by computed tomography (CT) in 6 cases (including 5 sporadic cases) with rimmed vacuolar distal myopathy. Although a predilection for the extensors in the lower leg was noted as stressed so far, there were certain cases without this selectivity. The thigh disclosed a selectivity that the flexors and adductors were severely affected while the m. quadriceps femoris was well preserved. The selectivity in the thigh was still found in the cases without selectivity in the lower leg. The neck flexors were also liable to be involved. In addition, CT revealed no compensatory hypertrophy of the specific muscles which was clearly shown in the thigh of distal muscular dystrophy (Miyoshi). The pattern of skeletal muscle involvement was thought to be a characteristic feature of distal myopathy with rimmed vacuoles. It was visualized very clearly and easily by CT of skeletal muscles although it could be noted to a certain degree by physical examination. (author)

  16. The hot rim sign on hepatobiliary scintigraphy (HIDA) with CT correlation

    Science.gov (United States)

    Amber, Ian Blake; Leighton, Joshua; Li, Su-Yu; Greene, Gary Stuart

    2012-01-01

    An older male with multiple medical comorbidities presented to the emergency room after 3 days of worsening right upper quadrant pain. The patient had an elevated white blood cell count and mildly elevated liver functions. Initial ultrasound was equivocal and further imaging with CT scan was obtained. The CT scan was read as suggestive of cholecystitis, however a hepatobiliary scintigraphy (HIDA) scan was ordered for confirmation, as the patient was a poor operative candidate. The HIDA demonstrated no bile duct or small bowel activity on initial images or delays, however a classic ‘hot rim’ sign was present, confirming acute cholecystitis. The patient ultimately underwent percutaneous cholecystostomy with drainage for treatment where acute cholecystitis was confirmed. Upon retrospective review, the CT demonstrated hyperaemia surrounding the gallbladder fossa, which is the CT scan equivalent of a scintigraphic ‘hot rim’ sign. This is an uncommon example of a radiologic sign correlation between multiple imaging modalities. PMID:22665866

  17. Models of Bone Metastasis

    OpenAIRE

    Campbell, J. Preston; MERKEL, ALYSSA R.; Masood-Campbell, S. Kathryn; Elefteriou, Florent; Julie A. Sterling

    2012-01-01

    Bone metastases are a common occurrence in several malignancies, including breast, prostate, and lung. Once established in bone, tumors are responsible for significant morbidity and mortality1. Thus, there is a significant need to understand the molecular mechanisms controlling the establishment, growth and activity of tumors in bone. Several in vivo models have been established to study these events and each has specific benefits and limitations. The most commonly used model utilizes intraca...

  18. Aging mechanisms in bone

    OpenAIRE

    Almeida, Maria

    2012-01-01

    Advancing age and loss of bone mass and strength are closely linked. Elevated osteoblast and osteocyte apoptosis and decreased osteoblast number characterize the age-related skeletal changes in humans and rodents. Similar to other tissues, oxidative stress increases in bone with age. This article reviews current knowledge on the effects of the aging process on bone and its cellular constituents, with particular emphasis on the role of reactive oxygen species (ROS). FoxOs, sirtuins and the p53...

  19. Nanocomposites and bone regeneration

    Science.gov (United States)

    James, Roshan; Deng, Meng; Laurencin, Cato T.; Kumbar, Sangamesh G.

    2011-12-01

    This manuscript focuses on bone repair/regeneration using tissue engineering strategies, and highlights nanobiotechnology developments leading to novel nanocomposite systems. About 6.5 million fractures occur annually in USA, and about 550,000 of these individual cases required the application of a bone graft. Autogenous and allogenous bone have been most widely used for bone graft based therapies; however, there are significant problems such as donor shortage and risk of infection. Alternatives using synthetic and natural biomaterials have been developed, and some are commercially available for clinical applications requiring bone grafts. However, it remains a great challenge to design an ideal synthetic graft that very closely mimics the bone tissue structurally, and can modulate the desired function in osteoblast and progenitor cell populations. Nanobiomaterials, specifically nanocomposites composed of hydroxyapatite (HA) and/or collagen are extremely promising graft substitutes. The biocomposites can be fabricated to mimic the material composition of native bone tissue, and additionally, when using nano-HA (reduced grain size), one mimics the structural arrangement of native bone. A good understanding of bone biology and structure is critical to development of bone mimicking graft substitutes. HA and collagen exhibit excellent osteoconductive properties which can further modulate the regenerative/healing process following fracture injury. Combining with other polymeric biomaterials will reinforce the mechanical properties thus making the novel nano-HA based composites comparable to human bone. We report on recent studies using nanocomposites that have been fabricated as particles and nanofibers for regeneration of segmental bone defects. The research in nanocomposites, highlight a pivotal role in the future development of an ideal orthopaedic implant device, however further significant advancements are necessary to achieve clinical use.

  20. SILICON AND BONE HEALTH

    OpenAIRE

    JUGDAOHSINGH, R.

    2007-01-01

    Low bone mass (osteoporosis) is a silent epidemic of the 21st century, which presently in the UK results in over 200,000 fractures annually at a cost of over one billion pounds. Figures are set to increase worldwide. Understanding the factors which affect bone metabolism is thus of primary importance in order to establish preventative measures or treatments for this condition. Nutrition is an important determinant of bone health, but the effects of the individual nutrients and minerals, other...

  1. Literature Survey for Bone Diseases Identification Using Thickness of Bone

    Directory of Open Access Journals (Sweden)

    Nivedha.A

    2014-11-01

    Full Text Available In the current scenario, bone diseases pose a major threat to middle-aged women all over the world. Bone is a living tissue that breaks down and rebuilds its structure throughout our lives. Bone is made up of calcium that makes bone dense (hard and strong. bone are affected by many disease.Diseases of bones are major causes of abnormalities of the human skeletal system. Although physical injury, causing fracture, fracture is one of several common causes of bone diseases. Bone disease are formerly regarded as conditions that are more mechanical that metabolic. This is cause by unhealthy lifestyle and improper diet. Some of the bone disease are osteoporosis, Osteogenesis imperfect, Paget disease of bone, Osteomalacia, .Fibrous dysplasia, Osteitis fibrosa cystic, Osteopetroses, Bone tumors and etc. we have to mention particularly the bone disease such as osteoporosis.

  2. Human prostatic acid phosphatase directly stimulates collagen synthesis and alkaline phosphatase content of isolated bone cells

    International Nuclear Information System (INIS)

    Human prostatic acid phosphatase (hPAP) directly enhances the differentiated characteristics of isolated bone cells in vitro. This enzyme, when added to cell cultures for 24 h in vitro stimulates collagen synthesis and the production of alkaline phosphatase. The effects are dose dependent, with statistically significant effects occurring from 0.1-100 nM hPAP. Concentrations higher than 100 nM do not evoke greater effects. The maximal effect of hPAP occurs between 12 and 24 h of exposure. The cells stimulated to the greatest degree are osteoprogenitor cells and osteoblasts. Fibroblasts isolated from the same tissue show a lesser sensitivity to hPAP. hPAP has no detectable effect on cell proliferation, as measured by radiolabeled thymidine incorporation or total DNA synthesis. None of the observations reported in this work can be attributed to contaminating proteins in the hPAP preparation. hPAP was radiolabeled with 125I and was used for affinity binding and cross-linking studies. Scatchard analysis of specific binding indicated the presence of 1.0 X 10(5) high affinity binding sites/cell, with a Kd of 6.5 nM. Cross-linking studies demonstrated the presence of one 320-kDa binding complex. The pH profile and kinetic determinations of Km and maximum velocity for hPAP were similar to those previously reported, except for the finding of positive cooperativity of the substrate with the enzyme under the conditions of our assay. We believe that the direct stimulation of bone-forming cells by hPAP may contribute to the sclerotic nature of skeletal bone around sites of neoplastic prostatic metastases and that the effect of the enzyme is probably mediated by a plasma membrane receptor

  3. Superior orbital rim approach for anterior communicating artery aneurysms: a surgical series of 27 patients.

    OpenAIRE

    Jeon, Byung Chan; Chen, Si-Yuan; Zheng, Yong-Ri; Cho, Yong-Woon; Kwon, Ki-Young

    2003-01-01

    There are debatable claims in the optimal approach for clipping of the anterior communicating artery (AcomA) aneurysm. The authors invented the superior orbital rim approach (SORA) as an alternative and minimally invasive approach for the treatment of AcomA aneurysm. The authors reviewed retrospectively all the medical records of 27 patients of subarachnoid hemorrhage due to ruptured AcomA aneurysm. who were admitted to Kosin University Gospel Hospital for last 2 yr. Fourteen women (51.9%) an...

  4. PRAGMA-ENT: Exposing SDN Concepts to Domain Scientists in the Pacific Rim

    OpenAIRE

    Ichikawa, Kohei; Tsugawa, Mauricio; Haga, Jason; Yamanaka, Hiroaki; Liu, Te-Lung; Kido, Yoshiyuki; U-Chupala, Pongsakorn; Huang, Che; Nakasan, Chawanat; Chang, Jo-Yu; Ku, Li-Chi; Tsai, Whey-Fone; Date, Susumu; Shimojo, Shinji; Papadopoulos, Philip

    2015-01-01

    The Pacific Rim Application and Grid Middleware Assembly (PRAGMA) is an international community of researchers that actively collaborate to address problems and challenges of common interest in eScience. The PRAGMA Experimental Network Testbed (PRAGMA-ENT) was established with the goal of constructing an international software-defined network (SDN) testbed to offer the necessary networking support to the PRAGMA cyberinfrastructure. PRAGMA-ENT is isolated, and PRAGMA research...

  5. Determinants and structural development of FDI in Pacific-Rim developing countries

    OpenAIRE

    Agarwal, Jamuna Prasad

    1989-01-01

    The movements of foreign direct investment (FDI) in the recent past are marked by a relatively very high growth in the Pacific Rim (PR) countries (Australia, Brunei, China, Hongkong, Japan, Indonesia, Malaysia, Papua New Guinea, New Zealand, Philippines, Singapore, Taiwan, Thailand). The developing countries of this area were able to raise considerably their share of the total world outflows in the first half of this decade (Table Al) . In the following analysis an attempt is made to work out...

  6. Numerical calculation of bending fatigue life of thin-rim spur gears

    OpenAIRE

    Kramberger, Janez; Šraml, Matjaž; Potr?, Iztok; Flašker, Jože

    2012-01-01

    Mechanical elements subjected to cyclic loading have to be designed against fatigue. The main goal of the presented analysis was to determine the the bending fatigue life prediction of thin rim spur gears. The service life is divided into the initiation phase of the damage accumulation and the crack growth, resprcitively. The analysis has been performed usig FEM and BEM. The continuum mechanics approach is used for the prediction of the fatigue life initiation phase, where the basic fatigue m...

  7. Cracking of an Aircraft Wheel Rim Made From Al-Alloy 2014-T6

    OpenAIRE

    G. Kosec; G. Kova?i?; J. Hodoli?; Kosec, B.

    2010-01-01

    Generally failures of different aircraft components and parts are revealed and examined by the use of non-destructive examination methods. In further detailed explanation and interpretation of failures optical and scanning electron microscopy are used. This paper deals with a problem of a crack on aircraft wheel rim made from aluminium alloy 2014-T6.The crack was observed during regular control by the maintenance unit for non-destructive examination of the Slovenian air carrier Adria Airways....

  8. Development of a New Resilience Scale: The Resilience in Midlife Scale (RIM Scale)

    OpenAIRE

    Linda Ryan; Marie L. Caltabiano

    2009-01-01

    Resilience, the ability to maintain or regain positive levels of functioning despite adversity, is one of several strengths that can assist people in positive life adaptation. Midlife (35 - 60 years) is a period when individuals need to adapt to several major changes and challenges. However, no scale exists to measure resilience specifically in the midlife population. Therefore, this study develops a new scale to measure resilience in midlife. The RIM scale consists of 25 items, each self-rat...

  9. Oxygen Isotope Measurements of a Rare Murchison Type A CAI and Its Rim

    Science.gov (United States)

    Matzel, J. E. P.; Simon, J. I.; Hutcheon, I. D.; Jacobsen, B.; Simon, S. B.; Grossman, L.

    2013-01-01

    Ca-, Al-rich inclusions (CAIs) from CV chondrites commonly show oxygen isotope heterogeneity among different mineral phases within individual inclusions reflecting the complex history of CAIs in both the solar nebula and/or parent bodies. The degree of isotopic exchange is typically mineral-specific, yielding O-16-rich spinel, hibonite and pyroxene and O-16-depleted melilite and anorthite. Recent work demonstrated large and systematic variations in oxygen isotope composition within the margin and Wark-Lovering rim of an Allende Type A CAI. These variations suggest that some CV CAIs formed from several oxygen reservoirs and may reflect transport between distinct regions of the solar nebula or varying gas composition near the proto-Sun. Oxygen isotope compositions of CAIs from other, less-altered chondrites show less intra-CAI variability and 16O-rich compositions. The record of intra-CAI oxygen isotope variability in CM chondrites, which commonly show evidence for low-temperature aqueous alteration, is less clear, in part because the most common CAIs found in CM chondrites are mineralogically simple (hibonite +/- spinel or spinel +/- pyroxene) and are composed of minerals less susceptible to O-isotopic exchange. No measurements of the oxygen isotope compositions of rims on CAIs in CM chondrites have been reported. Here, we present oxygen isotope data from a rare, Type A CAI from the Murchison meteorite, MUM-1. The data were collected from melilite, hibonite, perovskite and spinel in a traverse into the interior of the CAI and from pyroxene, melilite, anorthite, and spinel in the Wark-Lovering rim. Our objectives were to (1) document any evidence for intra-CAI oxygen isotope variability; (2) determine the isotopic composition of the rim minerals and compare their composition(s) to the CAI interior; and (3) compare the MUM-1 data to oxygen isotope zoning profiles measured from CAIs in other chondrites.

  10. Aeolian activity during the last 9200 calendar years BP along the southwestern coastal rim of Norway

    OpenAIRE

    Prøsch-Danielsen, Lisbeth; Selsing, Lotte

    2009-01-01

    Aeolian sand deposits intercalated with organic layers have been reported from Holocene sediment sequences below the marine limit (ML) at twelve sites along the coastal rim of southwestern Norway for over a century. This study, based on field investigations, stratigraphical analysis, radiocarbon dates and archaeological information, has revealed several phases of aeolian activity. The premises and factors permitting sand drift, as well as the timing of this activity, have been compiled and sy...

  11. Abnormal increases of lysosomal cysteinine proteinases in rimmed vacuoles in the skeletal muscle.

    OpenAIRE

    Ii, K.; Hizawa, K; Nonaka, I.; Sugita, H.; Kominami, E; Katunuma, N.

    1986-01-01

    Skeletal muscle obtained from a patient with distal myopathy with rimmed vacuole formation (DMRV) was examined by a new direct labeled antibody enzyme method of immunohistochemistry. Abnormal increases of cathepsins B and H, capable of degrading the myofibrillar proteins, were demonstrated to be localized at the site of vacuoles and other intramyofibral portions and not to be associated with concomitant increases of their endogenous inhibitors. Autodigestion by these intramyofibral lysosomal ...

  12. Ultratrace analysis of long-lived radionuclides by resonance ionization mass spectrometry (RIMS)

    International Nuclear Information System (INIS)

    Radioisotope mass spectrometry for the determination of long-lived nuclides can be several orders of magnitude more sensitive than the conventional radiometric methods. The principle of RIMS consists of the vaporization of the radionuclide to be determined and to perform a multiple resonant excitation and ionization of the atoms by laser light. This is followed by mass selective detection of the ions by a time-of-flight mass spectrometer. Several applications are presented. (author)

  13. High-mass star formation within the bright-rimmed cloud SFO 79

    OpenAIRE

    Urquhart, J. S.; Thompson, M. A.; Morgan, L.K.; White, Glenn J.

    2004-01-01

    We report Radio Recombination Line (RRL) and continuum observations toward the IRAS point source 16362--4845, embedded within the Bright-Rimmed Cloud (BRC) SFO 79, a small molecular cloud lying at the edge of the HII region RCW 108. High resolution observations of the H92alpha hydrogen recombination line and of the continuum emission (3.6 and 6 cm) confirm the presence of a resolved Ultra Compact (UC) HII region embedded within the molecular cloud. The integrated radio fluxe...

  14. Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis

    OpenAIRE

    Bokuda Kota; Sugaya Keizo; Tamura Shunichiro; Miyamoto Kazuhito; Matsubara Shiro; Komori Takashi

    2012-01-01

    Abstract Background The autophagic vacuolar myopathies (AVM) are a group of inherited myopathies defined by the presence of autophagic vacuoles in pathological muscle specimens. AVM can be categorized into three groups: acid maltase deficiency, myopathies characterized by autophagic vacuoles with unique sarcolemmal features, and rimmed vacuolar myopathies (RVM). While the pathogeneses of these conditions are still being elucidated, some drugs (e.g., chloroquine, its analog, hydroxychloroquine...

  15. Distal myopathy with rimmed vacuoles: Report on clinical characteristics in 23 cases

    OpenAIRE

    Nalini A; Gayathri N; Dawn Rose

    2010-01-01

    Background: Distal myopathy with rimmed vacuoles (DMRV) is an autosomal recessive (AR) myopathy characterized clinically by the preferential involvement of the tibialis anterior and has been reported predominantly in the Japanese population. Materials and Methods: A case series of DMRV patients seen over a period of 3 years at a tertiary national referral center for neurological disorders in south India. Results: We describe the clinical characteristics, muscle magnetic resonance imaging...

  16. Ammonia observations of bright-rimmed clouds: establishing a sample of triggered protostars

    OpenAIRE

    Morgan, L.K.; Figura, C. C.; Urquhart, J. S.; Thompson, M. A.

    2010-01-01

    We observed 42 molecular condensations within previously identified bright-rimmed clouds in the ammonia rotational inversion lines NH3 (1,1), (2,2), (3,3) and (4,4) using the Green Bank Telescope in Green Bank, West Virginia. Using the relative peaks of the ammonia lines and their hyperfine satellites we have determined important parameters of these clouds, including rotational temperatures and column densities. These observations confirm the presence of dense gas towards ...

  17. Age Sequence in Small Clusters Associated with Bright-Rimmed Clouds

    OpenAIRE

    Ogura, Katsuo; Chauhan, Neelam; Pandey, Anil K.; Bhatt, Bhuwan C.; Ojha, Devendra; Itoh, Yoichi

    2006-01-01

    Bright-rimmed clouds (BRCs) found in H II regions are probable sites of triggered star formation due to compression by ionization/shock fronts, and it is hypothesized that star formation proceeds from the exciting star(s) side outward of the HII region ("small-scale sequential star formation"). In order to quantitatively testify this hypothesis we undertook BVIc photometry of four BRC aggregates. The amounts of interstellar extinction and reddening for each star have been es...

  18. Glutamate signalling in bone.

    Directory of Open Access Journals (Sweden)

    DeborahMason

    2012-08-01

    Full Text Available Mechanical loading plays a key role in the physiology of bone, allowing bone to functionally adapt to its environment, however characterisation of the signalling events linking load to bone formation is incomplete. A screen for genes associated with mechanical load-induced bone formation identified the glutamate transporter GLAST, implicating the excitatory amino acid, glutamate, in the mechanoresponse. When an osteogenic load (10N, 10Hz was externally applied to the rat ulna, GLAST (EAAT1 mRNA, was significantly down-regulated in osteocytes in the loaded limb. Functional components from each stage of the glutamate signalling pathway have since been identified within bone, including proteins necessary for calcium-mediated glutamate exocytosis, receptors, transporters and signal propagation. Activation of ionotropic glutamate receptors has been shown to regulate the phenotype of osteoblasts and osteoclasts in vitro and bone mass in vivo. Furthermore, glutamatergic nerves have been identified in the vicinity of bone cells expressing glutamate receptors in vivo. However, it is not yet known how a glutamate signalling event is initiated in bone or its physiological significance. This review will examine the role of the glutamate signalling pathway in bone, with emphasis on the functions of glutamate transporters in osteoblasts.

  19. Metastatic bone disease

    Directory of Open Access Journals (Sweden)

    Errol U. Hutagalung

    2004-06-01

    Full Text Available Metastatic bone disease is the most common malignancy of bone, it is estimated that 70% of all malignant bone tumors are metastatic in origin. At autopsy it has been reported between 30 to 85% of patients who die from cancer show occult skeletal metastases. Bone is the third most common site of metastatic process after lung and liver. 80% of metastatic bone disease arise from Ca of breast, prostate, lung, kidney and thyroid. Typical location are thoracolumbal spine, pelvis, ribs, skull and proximal of femur and humerus. Pathogenesis of metastatic bone disease had been explained by Paget’s “Seed and Soil” theory and Ewing’s circulatory theory. Diagnostic procedures include complete laboratory examination, diagnostic bone imaging, chest x-ray, total body scan, CT-scan of chest, abdomen and pelvis and confirmed by histopathological examination. Management of metastatic bone disease is palliative that includes : chemotherapy, radiotherapy, bisphosphonates and surgical treatment for impending / established pathologic fracture to alleviate pain, ease nursing and restore functional activity. (Med J Indones 2004; 13: 127-31 Keywords: bone cancer, metastases

  20. Toxicokinetics of bone lead.

    OpenAIRE

    Rabinowitz, M B

    1991-01-01

    This article discusses bone as a source of lead to the rest of the body and as a record of past lead exposure. Bone lead levels generally increase with age at rates dependent on the skeletal site and lead exposure. After occupational exposure, the slow decline in blood lead, a 5- to 19-year half-life, reflects the long skeletal half-life. Repeated measurements of bone lead demonstrate the slow elimination of lead from bone. Stable isotope ratios have revealed many details of skeletal uptake a...

  1. 1983 bone bank procedures.

    Science.gov (United States)

    Tomford, W W; Doppelt, S H; Mankin, H J; Friedlaender, G E

    1983-04-01

    Bone banks large enough to support an allograft program require dedicated medical personnel to manage them. A large potential donor population, extensive financial resources, and modern storage facilities are necessary. Infected donors and contamination of procured bones during storage and retrieval must be avoided at all costs. Detailed record keeping is of vital importance to clinical investigations, especially for evaluating complications. These considerations must be taken into account before embarking on an institutional bone banking program, to provide safe and satisfactory allogeneic bone for clinical use. PMID:6339136

  2. Parosteal aneurysmal bone cyst?

    Science.gov (United States)

    Meohas, Walter; de Sá Lopes, Ana Cristina; da Silveira Möller, João Victor; Barbosa, Luma Duarte; Oliveira, Marcelo Bragança dos Reis

    2015-01-01

    The incidence of aneurysmal bone cysts is 0.14 cases per 100,000 individuals. Parosteal aneurysmal bone cysts are the least prevalent subtype and represent 7% of all aneurysmal bone cysts. We present the case of a 38-year-old male patient with pain and bulging in his right arm for eight months. He had previously been diagnosed as presenting giant-cell tumor, but his slides were reviewed and his condition was then diagnosed as parosteal aneurysmal bone cyst. The patient was treated with corticosteroid and calcitonin infiltration into the lesion and evolved with clinical and radiological improvement within the first five weeks after the operation. PMID:26535209

  3. Relationships between Visual Field Sensitivity and Spectral Absorption Properties of the Neuroretinal Rim in Glaucoma by Multispectral Imaging

    OpenAIRE

    Denniss, Jonathan; Schiessl, Ingo; Nourrit, Vincent; Fenerty, Cecilia H; Gautam, Ramesh; Henson, David B

    2011-01-01

    In this study, multispectral imaging was used to show relationships between spectral absorption properties of the neuroretinal rim and visual field loss in glaucoma. Multispectral imaging may provide clinically useful information for assessment of glaucoma.

  4. Nat'l_Register, ContributingResources, The Rim Trail at Pipe Spring National Monument, Arizona (pisp_qrytrail)

    Data.gov (United States)

    National Park Service, Department of the Interior — This is an Arc/Info coverage consisting of 4 arcs representing the portion of The Rim Trail at Pipe Spring National Monument, Arizona that occurs within the...

  5. A Compact Array imaging survey of southern bright-rimmed clouds

    CERN Document Server

    Thompson, M A; White, G J

    2004-01-01

    We have carried out a radio-wavelength imaging survey of 45 bright-rimmed clouds (BRCs), using the Australia Telescope Compact Array to characterise the physical properties in their ionised boundary layers. We detected radio emission from a total of 25 clouds and using a combination of Digitised Sky Survey and mid-infrared MSX micron images classified the emission into that associated with the ionised cloud rims, that associated with embedded possible massive YSOs and that unlikely to be associated with the clouds at all. A total of 18 clouds display radio emission clearly associated with the cloud rim and we determine the ionising photon flux illuminating these clouds and the electron density and pressure of their ionised boundary layers. Using a global estimate for the interior molecular pressure of these clouds we show that the majority are likely to be in pressure equilibrium and hence are currently being shocked by photoionisation-induced shocks. We identify those clouds where the predicted ionising phot...

  6. Influence of stress and strain on dolomite rim growth: a comparative study

    Science.gov (United States)

    Helpa, V.; Rybacki, E.; Morales, L. F. G.; Dresen, G.

    2015-08-01

    Triaxial compression and torsion experiments were performed to investigate the influence of non-isostatic stress and strain on dolomite reaction rim growth using orientated natural calcite and magnesite single crystals at a temperature of 750 °C, 400 MPa confining pressure, stresses between 7 and 38 MPa, and test durations up to 171 h. Reaction products were composed of a polycrystalline magnesio-calcite layer, palisade-shaped dolomite, and granular dolomite grains. In all experiments, inelastic deformation was partitioned into calcite and reaction products, while magnesite remained undeformed. Calcite deformed by twinning and dislocation creep, where the activation of additional glide systems at high stress allowed high strain. Depending on grain size, magnesio-calcite deformed by diffusion creep and/or grain boundary sliding, twinning, and dislocation creep. Dolomite deformed mainly by diffusion creep, assisted by enhanced dislocation activity allowing Ca enrichment in the granular rim. A weak crystallographic preferred orientation of the reaction products was observed. In triaxial compression, dolomite rim growth was diffusion-controlled and showed no influence of axial stresses up to 38 MPa on the reaction kinetics. At high strain (>0.1), the magnesio-calcite layer is wider suggesting faster growth kinetics. This may be related to additional diffusion pathways provided by enhanced dislocation activity. At very high strain (>0.3-0.6), twisted samples showed a gradual decrease in layer thickness of dolomite and magnesio-calcite with increasing strain (-rate).

  7. Young Stellar Population of the Bright-Rimmed Clouds BRC 5, BRC 7 and BRC 39

    CERN Document Server

    Panwar, Neelam; Pandey, A K; Samal, M R; Ogura, K; Ojha, D K; Jose, J; Bhatt, B C

    2014-01-01

    Bright-rimmed clouds (BRCs), illuminated and shaped by nearby OB stars, are potential sites of recent/ongoing star formation. Here we present an optical and infrared photometric study of three BRCs: BRC 5, BRC 7 and BRC 39 to obtain a census of the young stellar population, thereby inferring the star formation scenario, in these regions. In each BRC, the Class I sources are found to be located mostly near the bright rim or inside the cloud, whereas the Class II sources are preferentially outside, with younger sources closer to the rim. This provides strong support to sequential star formation triggered by radiation driven implosion due to the UV radiation. Moreover, each BRC contains a small group of young stars being revealed at its head, as the next-generation stars. In particular, the young stars at the heads of BRC 5 and BRC 7 are found to be intermediate/high mass stars, which, under proper conditions, may themselves trigger further star birth, thereby propagating star formation out to long distances.

  8. The significance of evaluating the craniolateral acetabular rim for hip dysplasia

    International Nuclear Information System (INIS)

    The weight-bearing part of the canine hip is its dorsocraniolateral portion. On the radiograph the configuration of the craniolateral acetabular rim is important for evaluation of hip dysplasia. Changes in formation of this area should be differentiated from artefacts due to malpositioning. When the pelvis is tilted dorsally, the cranial acetabular rim is superimposed on the cranioventral acetabular contour and the acetabular roof. The craniolateral contour then seems to be missing. The contours of a ventrally tilted pelvis do not overlap, but it is difficult to discern the craniolateral rim. The reference points for Norberg-Olsson's measurements are difficult to choose in both cases and the angles may vary up to 10 degrees. A symmetrically positioned pelvis shows one point of reference for Norberg-Olsson's measurement where the cranial acetabular contour, the cranioventral margin and the acetabular roof intersect. Therefore poor positioning of the pelvis for radiographic evaluation of hip dysplasia should be avoided when using Norberg-Olsson's measurements

  9. Does Oxygen Isotopic Heterogeneity in Refractory Inclusions and Their Wark-Lovering Rims Record Nebular Repressing?

    Science.gov (United States)

    Simon, J. I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.

    2013-01-01

    Large systematic variations in O-isotopic compositions found within individual mineral layers of rims surrounding Ca-, Al-rich inclusions (CAIs) and at the margins of some CAIs imply formation from distinct environments [e.g., 1-3]. The O-isotope compositions of many CAIs preserve a record of the Solar nebula gas believed to initially be O-16-rich (delta O-17 less than or equal to -25%0) [4-5]. Data from a recent study of the compact Type A Allende CAI, A37, preserve a diffusion profile in the outermost 70 micrometers of the inclusion and show greater than 25%0 variations in delta O-17 within its 100 micrometer-thick Wark-Lovering rim (WL-rim) [3]. This and comparable heterogeneity measured in several other CAIs have been explained by isotopic mixing between the O-16-rich Solar reservoir and a second O-16-poor reservoir (probably nebular gas) with a planetary-like isotopic composition, e.g., [1,2,3,6]. However, there is mineralogical and isotopic evidence from the interiors of CAIs, in particular those from Allende, for parent body alteration. At issue is how to distinguish the record of secondary reprocessing in the nebula from that which occurred on the parent body. We have undertaken the task to study a range of CAI types with varying mineralogies, in part, to address this problem.

  10. Reaction rim growth in the system MgO-Al2O3-SiO2 under uniaxial stress

    Science.gov (United States)

    Götze, Lutz Christoph; Abart, Rainer; Rybacki, Erik; Keller, Lukas M.; Petrishcheva, Elena; Dresen, Georg

    2010-07-01

    We synthesize reaction rims between thermodynamically incompatible phases in the system MgO-Al2O3-SiO2 applying uniaxial load using a creep apparatus. Synthesis experiments are done in the MgO-SiO2 and in the MgO-Al2O3 subsystems at temperatures ranging from 1150 to 1350 °C imposing vertical stresses of 1.2 to 29 MPa at ambient pressure and under a constant flow of dry argon. Single crystals of synthetic and natural quartz and forsterite, synthetic periclase and synthetic corundum polycrystals are used as starting materials. We produce enstatite rims at forsterite-quartz contacts, enstatite-forsterite double rims at periclase-quartz contacts and spinel rims at periclase-corundum contacts. We find that rim growth under the “dry” conditions of our experiments is sluggish compared to what has been found previously in nominally “dry” piston cylinder experiments. We further observe that the nature of starting material, synthetic or natural, has a major influence on rim growth rates, where natural samples are more reactive than synthetic ones. At a given temperature the effect of stress variation is larger than what is anticipated from the modification of the thermodynamic driving force for reaction due to the storage of elastic strain energy in the reactant phases. We speculate that this may be due to modification of the physical properties of the polycrystals that constitute the reaction rims or by deformation under the imposed load. In our experiments rim growth is very sluggish at forsterite-quartz interfaces. Rim growth is more rapid at periclase-quartz contacts. The spinel rims that are produced at periclase-corundum interfaces show parabolic growth indicating that reaction rim growth is essentially diffusion controlled. From the analysis of time series done in the MgO-Al2O3 subsystem we derive effective diffusivities for the Al2O3 and the MgO components in a spinel polycrystal as D_{MgO} = 1.4 ± 0.2 \\cdot 10^{-15} m2/s and D_{Al_2O_3} = 3.7 ± 0.6 \\cdot 10^{-16} m2/s for T = 1350 °C and a vertical stress of 2.9 MPa.

  11. The Effects of Self-Shadowing by a Puffed up Inner Rim in Scattered Light Images of Protoplanetary Disks

    OpenAIRE

    Dong, Ruobing

    2015-01-01

    We explore whether protoplanetary disks with self-shadowing from puffed up inner rims exhibit observable features in scattered light images. We use both self-consistent hydrostatic equilibrium calculations and parameterized models to produce the vertically puffed up inner rims. We find that, in general, the transition between the shadowed and flared regions occurs in a smooth manner over a broad radius range, and no sudden jump exists at the outer edge of the shadow in eithe...

  12. Antinuclear antibodies giving the 'multiple nuclear dots' or the 'rim-like/membranous' patterns: diagnostic accuracy for primary biliary cirrhosis.

    OpenAIRE

    Granito, A; Muratori, P; Muratori, L; Pappas, G.; Cassani, F.; Worthington, J.; Guidi, M; Ferri, S; De Molo, C; Lenzi, M.; Chapman, RW; Bianchi, FB

    2006-01-01

    BACKGROUND: Serum antinuclear antibodies giving the 'multiple nuclear dots' or the 'rim-like/membranous' patterns are frequently detected by indirect immunofluorescence on HEp-2 cells in patients with primary biliary cirrhosis. AIM: To assess the accuracy of multiple nuclear dot and rim-like/membranous antinuclear antibodies for the diagnosis of primary biliary cirrhosis. METHODS: Sera from 4371 consecutive patients referred to our laboratory were analysed under code for antinuclear antibodie...

  13. Development of high sensitive and reliable FFD and sodium leak detection technique for fast reactor using RIMS

    International Nuclear Information System (INIS)

    The high sensitive fuel failure and sodium leak detection technique for fast reactors has been developed using laser resonance ionization mass spectrometry (RIMS) method. The RIMS is suitable for the isotope analysis of the element of ultra trace level, since there is no increase of the background by interfering ion and isobaric interference except for measuring element, because the measuring element is selectively ionized. The RIMS was applied to measure the artificially blended xenon and krypton gas (tag gas) which is used for the pressurized steel capsule of in-pile creep rupture experiment in the experimental fast reactor Joyo. This system can measure the tag gas isotopic ratios of about 100 ? 102 ppb level and the measured results could identify tag gas. The RIMS system can detect stable xenon nuclides and 133Xe in the sample of cover gas which was stored in the stainless steel container during the fuel failure simulation test in Joyo. The result shows the applicability of the RIMS system for assuming the burn-up of the failed fuel subassembly by the ratio of stable and radioactive xenon isotopes. The RIMS is then applied to detect a small amount of sodium leaks from the fast reactor cooling system. In case of detecting sodium isotopes using RIMS, the aerodynamic lens was newly introduced, which can transfer aerosols at atmospheric pressure into a vacuum chamber while increasing the aerosol density at the same time. We performed the experiments using stable isotope 23Na to evaluate the detection sensitivity of the prototype system. The preliminary test results showed that prototype system could easily detect sodium aerosol of 2.7 ppt, of which sensitivity is 400 times higher than the conventional sodium leak detectors currently used. The RIMS system is expected to be a promising innovative instrumentation system not only for Monju, but also for the future sodium cooled fast reactors. (author)

  14. A Novel Mutation of the GNE Gene in Distal Myopathy with Rimmed Vacuoles: A Case with Inflammation

    OpenAIRE

    Tanboon, Jantima; Rongsa, Kanjana; Pithukpakorn, Manop; Boonyapisit, Kanokwan; Limwongse, Chanin; Sangruchi, Tumtip

    2014-01-01

    Distal myopathy with rimmed vacuoles (DMRV) is an autosomal recessive or sporadic early adult-onset myopathy caused by mutations in the UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase (GNE) gene. Characteristic pathologic features of DMRV are rimmed vacuoles on muscle biopsy and tubulofilamentous inclusion in ultrastructural study. Presence of inflammation in DMRV is unusual. We report a sporadic case of DMRV in a 40-year-old Thai man who presented with slowly progressive d...

  15. Bone marrow (stem cell) donation

    Science.gov (United States)

    ... fatty tissue inside your bones. Bone marrow contains stem cells, which are immature cells that become blood cells. ... marrow transplant . This is now often called a stem cell transplant. For this type of treatment, bone marrow ...

  16. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... or in bones. top of page How should I prepare? Most bone x-rays require no special ... to 10 minutes. top of page What will I experience during and after the procedure? A bone ...

  17. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... of bone cancer . locate foreign objects in soft tissues around or in bones. top of page How ... bone absorbs much of the radiation while soft tissue, such as muscle, fat and organs, allow more ...

  18. Resurfacing of the humeral head: An analysis of the bone stock and osseous integration under the implant.

    Science.gov (United States)

    Schmidutz, Florian; Sprecher, Christoph M; Milz, Stefan; Gohlke, Frank; Hertel, Ralph; Braunstein, Volker

    2015-09-01

    Cementless-surface-replacement-arthroplasty (CSRA) of the shoulder aims for functional joint restoration with minimal bone loss. Good clinical results have been reported, but due to the radiopaque metal shell no data is available on the structure, osseous integration, and bone stock under the implant. 14 hemi-CSRAs (4 manufacturers) with two geometries (crown [n?=?7]/ stem [n?=?7] fixation) were retrieved from patients undergoing revision due to glenoidal erosion. Histological sections cutting through the implant centre and bone were analysed. Quantitative histomorphometry evaluated the bone-implant-contact and compared the bone-area to native humeral retrievals (n?=?7). The bone-implant-interface was further assessed by scanning-electron-microscopy (SEM) and energy-dispersive-x-ray (EDX). Qualitative histology revealed a reduced and inhomogeneous bone stock. Obvious signs of stress shielding were observed with bone predominantly visible at the stem and implant rim. Quantitative histomorphometry confirmed the significantly reduced bone-area (9.2?±?3.9% [crown 9.9?±?4.3%, stem 8.6?±?3.6%]) compared to native humeri (21.2?±?9.1%; p?Bone-implant-contact was 20.5?±?5.8% (crown 21.8?±?6.2%, stem 19.2?±?5.6%) which was confirmed by SEM and EDX. Altogether, CRSA shows satisfactory bone ingrowth at the interface suggesting sufficient primary stability to allow osseous integration. However, clear signs of stress shielding with an inhomogeneous and reduced bone stock were observed. The impact on the long-term-results is unclear requiring further investigation. PMID:25808101

  19. Multiple soft tissue aneurysmal cysts: An occurrence after resection of primary aneurysmal bone cyst of fibula

    Directory of Open Access Journals (Sweden)

    Karkuzhali P

    2007-01-01

    Full Text Available We report a case of multiple extraosseous aneurysmal cysts occurring in the muscle and subcutaneous plane of postero-lateral aspects of the upper right leg. They appeared about 15 months after resection of aneurysmal bone cyst of the upper end of the fibula. They varied in size from 2 cm to 5 cm. Radiologically they were well-defined lesions with central septate areas surrounded by a rim of calcification. Histologically they showed central cystic spaces separated by septa consisting of fibroblasts, osteoclast type of giant cells and reactive woven bone. Thus they showed histological similarity with aneurysmal bone cysts, but did not show any connection with the bone. Only very few examples of aneurysmal cysts of soft tissue had been described in the past one decade and they were reported in various locations including rare sites such as arterial wall and larynx. Recent cytogenetic analyses have shown abnormalities involving 17p11-13 and/or 16q22 in both osseous and extraosseous aneurysmal cysts indicating its probable neoplastic nature. Our case had unique features like multiplicity and occurrence after resection of primary aneurysmal bone cyst of the underlying bone.

  20. Normal Bone Anatomy and Physiology

    OpenAIRE

    Clarke, Bart

    2008-01-01

    This review describes normal bone anatomy and physiology as an introduction to the subsequent articles in this section that discuss clinical applications of iliac crest bone biopsy. The normal anatomy and functions of the skeleton are reviewed first, followed by a general description of the processes of bone modeling and remodeling. The bone remodeling process regulates the gain and loss of bone mineral density in the adult skeleton and directly influences bone strength. Thorough understandin...

  1. Evaluation of sequential FDG-PET/CT for monitoring bone metastasis of breast cancer during therapy. Correlation between morphological and metabolic changes with tumor markers

    International Nuclear Information System (INIS)

    The purpose of this study was to clarify the significance of positron emission tomography (PET) and computed tomography (CT) findings for evaluating the bone metastasis of breast cancer during therapy. Forty-seven patients with bone metastases from breast cancer who underwent sequential 18F-flourodeoxyglucose (FDG)-PET/CT studies during therapy were enrolled. A total of 771 lesions were identified. The changes in the PET and CT findings were compared with the tumor marker levels in each patient by calculating the weighted kappa value. The correlation between the PET and CT findings was examined for each lesion by an adjusted Chi-square test. The change in the tumor marker levels was substantially correlated with the PET findings and moderately correlated with the CT findings (weighted kappa=0.780 and 0.585 for quadratic weighting, respectively). An increase in FDG uptake was correlated with lytic changes on the CT images (62/65, 95.4%, p<0.05). Sclerotic changes suggested improvement, but sclerosis and progression occurred at the same time in some lesions. Changes of FDG uptake are useful for evaluating individual bone metastases in cases of breast cancer during therapy. Lytic change on CT images suggests progression of bone metastasis. The lysis-progression/sclerosis-improvement pattern was observed in the majority of subjects, but a sclerosis-progression pattern was also observed. The hybrid pattern of increase of FDG uptake on PET/lytic change on CT is most accurate to show progression of bone metastases. Assessments of these processes during therapy are necessary for the precise evaluation of bone metastases. (author)

  2. Calcium Intake and Bone health

    Medline Plus

    Full Text Available ... not improve bone health, according to two new studies. Researchers reviewed randomized controlled trials and observational studies that looked at whether extra calcium improved bone ...

  3. Biodegradable synthetic bone composites

    Science.gov (United States)

    Liu, Gao; Zhao, Dacheng; Saiz, Eduardo; Tomsia, Antoni P.

    2013-01-01

    The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

  4. Pseudoanaplastic tumors of bone

    International Nuclear Information System (INIS)

    To discuss the concept of pseudoanaplastic tumors of bone, which pathologically show hyperchromatism and marked pleomorphism with quite enlarged, pleomorphic nuclei, but with no to extremely rare, typical mitoses, and to propose guidelines for their diagnosis. From a database of 4,262 bone tumors covering from 1971 to 2001, 15 cases of pseudoanaplastic bone tumors (0.35% of total) were retrieved for clinical, radiographic and pathologic review. Postoperative follow-up after surgical treatment was at least 3 years and a maximum of 7 years. There were eight male and seven female patients. Their ages ranged from 10 to 64 years with average of 29.7 years. Pathologic diagnoses of pseudoanaplastic variants of benign bone tumors included: osteoblastoma (4 cases), giant cell tumor (4 cases), chondromyxoid fibroma (3 cases), fibrous dysplasia (2 cases), fibrous cortical defect (1 case) and aneurysmal bone cyst (1 case). Radiography of all cases showed features of a benign bone lesion. Six cases, one case each of osteoblastoma, fibrous dysplasia, aneurysmal bone cyst, chondromyxoid fibroma, giant cell tumor and osteoblastoma, were initially misdiagnosed as osteosarcoma. The remaining cases were referred for a second opinion to rule out sarcoma. Despite the presence of significant cytologic aberrations, none of our cases showed malignant behavior following simple curettage or removal of bony lesions. Our observation justifies the concept of pseudoanaplasia in some benign bone tumors as in benign soft tissue tumors, especially in their late evolutionary stage when bizarre cytologic alterations strongly mimic a sarcoma. (orig.)

  5. Pseudoanaplastic tumors of bone

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Won-Jong [Uijongbu St. Mary Hospital, The Catholic University of Korea, Department of Orthopaedic Surgery, Gyunggido, 480-821 (Korea); Mirra, Joseph M. [Orthopaedic Hospital, Orthopedic Oncology, Los Angeles, California (United States)

    2004-11-01

    To discuss the concept of pseudoanaplastic tumors of bone, which pathologically show hyperchromatism and marked pleomorphism with quite enlarged, pleomorphic nuclei, but with no to extremely rare, typical mitoses, and to propose guidelines for their diagnosis. From a database of 4,262 bone tumors covering from 1971 to 2001, 15 cases of pseudoanaplastic bone tumors (0.35% of total) were retrieved for clinical, radiographic and pathologic review. Postoperative follow-up after surgical treatment was at least 3 years and a maximum of 7 years. There were eight male and seven female patients. Their ages ranged from 10 to 64 years with average of 29.7 years. Pathologic diagnoses of pseudoanaplastic variants of benign bone tumors included: osteoblastoma (4 cases), giant cell tumor (4 cases), chondromyxoid fibroma (3 cases), fibrous dysplasia (2 cases), fibrous cortical defect (1 case) and aneurysmal bone cyst (1 case). Radiography of all cases showed features of a benign bone lesion. Six cases, one case each of osteoblastoma, fibrous dysplasia, aneurysmal bone cyst, chondromyxoid fibroma, giant cell tumor and osteoblastoma, were initially misdiagnosed as osteosarcoma. The remaining cases were referred for a second opinion to rule out sarcoma. Despite the presence of significant cytologic aberrations, none of our cases showed malignant behavior following simple curettage or removal of bony lesions. Our observation justifies the concept of pseudoanaplasia in some benign bone tumors as in benign soft tissue tumors, especially in their late evolutionary stage when bizarre cytologic alterations strongly mimic a sarcoma. (orig.)

  6. Bone Mineral Measurements.

    Science.gov (United States)

    Doroudinia, Abtin; Colletti, Patrick M

    2015-08-01

    The accurate measurement of bone mineral density using noninvasive methods can be of value in the detection and evaluation of primary and secondary causes of decreased bone mass. This includes primary osteoporosis and secondary disorders, such as hyperparathyroidism, osteomalacia, multiple myeloma, diffuse metastases, and glucocorticoid therapy or intrinsic excess.By far, the largest patient population is that encompassed by primary osteoporosis with increased susceptibility to fractures in the absence of other recognizable causes of bone loss.Primary osteoporosis is a common clinical disorder and a major public health problem because of the significant number of related bone fractures occurring annually. Because the risk of vertebral and femoral neck fractures rises dramatically as bone mineral density falls, fracture risk in individual patients may be estimated. Furthermore, in estrogen-deficient women, bone mineral density values may be used to make rational decisions about hormone replacement therapy, or other bone mineral therapies, and as follow-up in assessing the success of such treatment.In this article, we discuss different methods of bone densitometry and will focus on dual-energy x-ray absorptiometry (DXA) with discussing the factors which should be considered for interpretation of DXA scan. PMID:26147459

  7. Ear and temporal bone

    International Nuclear Information System (INIS)

    Radioanatomy of ear and temporal bone is described. Problems of X-ray examination of the diseases of ear and mastoid process (disturbance of ear development, inflammatory diseases, otosclerosis, tumors) are considered. Roentgenoframs of temporal bone of healthy people and that in some diseases are presented and aanalyzed

  8. [A case of breast cancer with multiple bone metastases that responded remarkably to doxifluridine (5'-DFUR), cyclophosphamide (CPA), medroxyprogesterone acetate (MPA) and pamidronate disodium therapy].

    Science.gov (United States)

    Kusama, Mikihiro; Kaise, Hiroshi; Nakayama, Syun; Ota, Daisuke; Aoki, Tatuya; Koyanagi, Yasuhisa; Misaka, Takenori; Matunaga, Tadaharu

    2002-05-01

    A 49-year-old female underwent bilateral breast preserving surgery for heterochronic breast cancers. She later developed a sternal metastasis and was recommended for intravenous chemotherapy. However, she refused such an intensive therapy and opted for immunotherapy. Afterward, she came to our hospital because of spinal metastases with back pain. She was treated with oral administration of 5'-DFUR and MPA 1,200 mg/day for 3 weeks, respectively, CPA 100 mg/day for 2 weeks, and pamidronate disodium 30 mg intravenously every 4 weeks. This combined chemotherapy relieved her pain after one course. After 5 courses, tumor markers were reduced to the normal range. After 14 courses, bone X-P revealed that the osteolytic bone showed sclerotic changes and bone scintigraphy showed a complete remission (CR). The adverse effects were not remarkable. This regimen is possible on an outpatient basis, and it may play an important role from the standpoint of treatment effectiveness and the quality of life of the patient. PMID:12040686

  9. A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease.

    OpenAIRE

    Webb Glenn F; Edwards Claire M; Ayati Bruce P; Wikswo John P

    2010-01-01

    Abstract Background Multiple myeloma is a hematologic malignancy associated with the development of a destructive osteolytic bone disease. Results Mathematical models are developed for normal bone remodeling and for the dysregulated bone remodeling that occurs in myeloma bone disease. The models examine the critical signaling between osteoclasts (bone resorption) and osteoblasts (bone formation). The interactions of osteoclasts and osteoblasts are modeled as a system of differential equations...

  10. A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease

    OpenAIRE

    Ayati, BP; Edwards, CM; Webb, GF; Wikswo, JP

    2010-01-01

    BACKGROUND: Multiple myeloma is a hematologic malignancy associated with the development of a destructive osteolytic bone disease. RESULTS: Mathematical models are developed for normal bone remodeling and for the dysregulated bone remodeling that occurs in myeloma bone disease. The models examine the critical signaling between osteoclasts (bone resorption) and osteoblasts (bone formation). The interactions of osteoclasts and osteoblasts are modeled as a system of differential equations for th...

  11. The RIM101 Pathway Contributes to Yeast Cell Wall Assembly and Its Function Becomes Essential in the Absence of Mitogen-Activated Protein Kinase Slt2p

    Science.gov (United States)

    Castrejon, F.; Gomez, A.; Sanz, M.; Duran, A.; Roncero, C.

    2006-01-01

    The Saccharomyces cerevisiae ynl294c? (rim21?) mutant was identified in our lab owing to its moderate resistance to calcofluor, although it also displayed all of the phenotypic traits associated with its function as the putative sensor (Rim21p) of the RIM101 pathway. rim21? also showed moderate hypersensitivity to sodium dodecyl sulfate, caffeine, and zymolyase, and the cell wall compensatory response in this mutant was very poor, as indicated by the almost complete absence of Slt2 phosphorylation and the modest increase in chitin synthesis after calcofluor treatment. However, the cell integrity pathway appeared functional after caffeine treatment or thermal stress. rim21? and rim101? mutant strains shared all of the cell-wall-associated phenotypes, which were reverted by the expression of Rim101-531p, the constitutively active form of this transcription factor. Therefore, the absence of a functional RIM101 pathway leads to cell wall defects. rim21?, as well as rim101?, was synthetic lethal with slt2?, a synthetic defect alleviated by osmotic stabilization of the media. The double mutants grown in osmotically stabilized media were extremely hypersensitive to zymolyase and showed thicker cell walls, with poorly defined mannoprotein layers. In contrast, rim21? rlm1? and rim101? rlm1? double mutants were fully viable. Taken together, these results show that the RIM101 pathway participates directly in cell wall assembly and that it acts in parallel with the protein kinase C pathway (PKC) in this process independently of the transcriptional effect of the compensatory response mediated by this route. In addition, these results provide new experimental evidence of the direct involvement of the PKC signal transduction pathway through the Sltp2 kinase in the construction of yeast cell walls. PMID:16524906

  12. Usefulness of {sup 18}F fluoride PET/CT in breast cancer patients with osteosclerotic bone metastases

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Seok Ho; Kim, Ku Sang; Kang, Seok Yun; Song, Hee Sung; Jo, Kyung Sook; Lee, Su Jin; Yoon, Joon Kee; An, Young Sil [Ajou Univ., Suwon (Korea, Republic of); Choi, Bong Hoi [Gyeongsang National Univ. Hospital, Jinju (Korea, Republic of)

    2012-03-15

    Bone metastasis is an important factor for the treatment and prognosis of breast cancer patients. Whole body bone scintigraphy (WBBS) can evaluate skeletal metastases, and {sup 18}F FDG PET/CT seems to exhibit high specificity and accuracy in detecting bone metastases. However, there is a limitation of {sup 18}F FDG PET in assessing sclerotic bone metastases because some lesions may be undetectable. Recent studies showed that {sup 18}F fluoride PET/CT is more sensitive than WBBS in detecting bone metastases. This study aims to evaluate the usefulness of {sup 18}F fluoride PET/CT by comparing it with WBBS and {sup 18}F FDG PET/CT in breast cancer patients with osteosclerotic skeletal metastases. Nine breast cancer patients with suspected bone metastases (9 females; mean age {+-} SD, 55.6{+-}10.0 years) underwent {sup 99m}Tc MDP WBBS, {sup 18}F FDG PET/CT and {sup 18}F fluoride PET/CT. Lesion based analysis of five regions of the skeletons(skull, vertebral column, thoracic cage, pelvic bones and long bones of extremities) and patient based analysis were performed. {sup 18}F fluoride PET/CT, {sup 18}F FDG PET/CT and WBBS detected 49, 20 and 25 true metastases, respectively. Sensitivity, specificity, positive predictive value and negative predictive value of {sup 18}F fluoride PET/CT were 94.2%, 46.3%, 57.7% and 91.2%, respectively. Most true metastatic lesions of {sup 18}F fluoride PET/CT had osteosclerotic change (45/49, 91.8%), and only four lesions showed osteolytic change. Most lesions on {sup 18}F FDG PET/CT also demonstrated osteosclerotic change (17/20, 85.0%) with three osteolytic lesions. All true metastatic lesions detected on WBBS and {sup 18}F FDG PET/CT were identified on {sup 18}F fluoride PET/CT. {sup 18}F FDG PET/CT in detecting osteosclerotic metastatic lesions. {sup 18}F fluoride PET/CT might be useful in evaluating osteosclerotic metastases in breast cancer patients.

  13. Temporal bone CT findings of tuberculous otitis media : comparison with chronic otitis media

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Jeong A; Rho, Myung Ho; Kim, Young Min; Lee, Ho Seung; Choi, Pil Yeob; Seong, Young Soon; Kwon, Jae Soo; Lee, Sang Wook [Masan Samsung Hospital, Sungkyunkwan Univ. College of Medicine, Seoul (Korea, Republic of); Jung, Keon Sik [Pohang Sunrin Hospital, Pohang (Korea, Republic of)

    1999-06-01

    To compare the differential findings of tuberculous otitis media(TOM) with those of chronic sup purative otitis media with or without cholesteatoma, as seen on high resolution temporal bone CT. We retrospectively reviewed 14 cases of TOM, 30 cases of chronic suppurative otitis media(CSOM), and 30 cases of chronic otitis media with cholesteatoma(Chole). All had been pathologically confirmed. We evaluated the preservation of mastoid cells without sclerotic change, the location and extension of soft tissue to the external auditary canal, and erosion of ossicles, the tegmen tympani, scutum, bony labyrinth, facial nerve canal and sigmoid sinus, and the presence of intracranial complications. Soft tissue in the mastoid antrum was seen in all cases of TOM(100%), 29 cases of CSOM(96.7%), and 26 cases of Chole(86.7%). In contrast, the soft tissue in the entire middle ear cavity was noted in 13 cases of TOM(92.8%), 7 cases of CSOM(23.3%), and 12 cases of Chole(40%). Soft tissue extended to the superior aspect of the external auditory canal in 4 cases of TOM (28.6%) and 5 cases of Chole (16.7%). Mastoid air cells were seen in 9 cases of TOM (64.3%), 4 cases of CSOM (13.3%), and 3 cases of Chole(10%). Ossicular erosion was noted in 6 cases of TOM (42.9%), 12 cases of CSOM (40%), and 26 cases of Chole(86.7%), while in one case of TOM (7.1%), 5 cases of CSOM (16.7%), and 15 cases of Chole(50%) there was erosion of the scutum. In one case of TOM, follow-up CT study after 9 months of antituberculous medication without surgery revealed complete clearing of previously noted soft tissue in the middle ear cavity. Specific CT findings of TOM were not seen, but if there were findings of soft tissue in the entire middle ear cavity, soft tissue extension to the external auditory canal, preservation of mastoid air cells without sclerotic change, and intact scutum, TOM may be differentiated from other chronic otitis media.

  14. Paget Disease of Bone.

    Science.gov (United States)

    Al-Rashid, Mamun; Ramkumar, Dipak B; Raskin, Kevin; Schwab, Joseph; Hornicek, Francis J; Lozano-Calderón, Santiago A

    2015-10-01

    The current understanding of Paget disease of bone (PDB) has vastly changed since Paget described the first case in 1877. Medical management of this condition remains the mainstay of treatment. Surgical intervention is usually only used in fractures through pagetic bone, need for realignment to correct deformity in major long bones, prophylactic treatment of impending fractures, joint arthroplasty in severe arthritis, or spinal decompression in cases of bony compression of neural elements. Advances in surgical technique have allowed early return to function and mobilization. Despite medical and surgical intervention, a small subset of patients with PDB develops Paget sarcoma. PMID:26410646

  15. Bone scintigraphy for horses

    International Nuclear Information System (INIS)

    Scintigraphy (bone scan) is being used approximately since 1980 in the horse under general anaesthesia. With the construction of custom-made overhead gantries for gamma-cameras scintigraphy found widespread entry in big equine referral hospitals for bone-scanning of the standing horse. Indications for the use of a bone scan in the horse are inflammatory alterations in the locomotor apparatus. It is primarily used for diagnosis of lameness of unknown origin, suspect of stress fracture or hairline fracture and for horses with bad riding comfort with suspected painful lesions in the spine. (orig.)

  16. Periodontal bone lesions

    International Nuclear Information System (INIS)

    In the course of life the periodontum is subject to changes which may be physiological or pathological. Intraoral radiographs give insight into the hard structures of the dentomaxillar region and provides information on lesions in the bone of the periodontum in that they show radiopacities and radiolucencies caused by such lesions. In this thesis the relation is investigated between the true shape and dimensions of periodontal bone lesions and their radiographic images. A method is developed and tested of making standardized and reproducible radiographs suitable for longitudinal studies of periodontal lesions. Also the possibility is demonstrated of an objective and reproducible interpretation of radiographic characteristics of periodontal bone lesions. (Auth.)

  17. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available X-ray (Radiography) - Bone What is Bone X-ray (Radiography)? What are some common uses of the procedure? How should I ... of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive ...

  18. How Is Bone Cancer Diagnosed?

    Science.gov (United States)

    ... imaging tests. Imaging tests to detect bone cancer X-rays Most bone cancers show up on x-rays of the bone. ... a biopsy can absolutely determine that. A chest x-ray is often done to see if bone cancer has spread to the lungs. Computed tomography (CT) ...

  19. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available X-ray (Radiography) - Bone What is Bone X-ray (Radiography)? What are some common uses of the procedure? How should I prepare? What ... limitations of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is ...

  20. Interparietal bones in Nigerian skulls.

    OpenAIRE

    S.K. Saxena; Chowdhary, D. S.; Jain, S. P.

    1986-01-01

    The study was conducted on 40 adult Nigerian skulls which were examined for the presence of interparietal and pre-interparietal bones. Only one interparietal bone was found (2.5% of the present series) while a single pre-interparietal bone was found in four skulls (10%) and multiple pre-interparietal bones in one skull (2.5%).

  1. Bone X-Ray (Radiography)

    Science.gov (United States)

    X-ray (Radiography) - Bone What is Bone X-ray (Radiography)? What are some common uses of the procedure? ... of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive ...

  2. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available X-ray (Radiography) - Bone What is Bone X-ray (Radiography)? What are some common uses of the procedure? ... of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive ...

  3. Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Bokuda Kota

    2012-11-01

    Full Text Available Abstract Background The autophagic vacuolar myopathies (AVM are a group of inherited myopathies defined by the presence of autophagic vacuoles in pathological muscle specimens. AVM can be categorized into three groups: acid maltase deficiency, myopathies characterized by autophagic vacuoles with unique sarcolemmal features, and rimmed vacuolar myopathies (RVM. While the pathogeneses of these conditions are still being elucidated, some drugs (e.g., chloroquine, its analog, hydroxychloroquine, and colchicine can also cause AVM. Minocycline is a disease-modifying anti-rheumatic drug that may be used in the treatment of rheumatoid arthritis (RA. Here, we describe the first case of minocycline-associated AVM with rimmed vacuole formation. Case presentation A 75-year-old woman suffering from RA has been continuously treated with minocycline (200 mg/day for the past 7 years. During this time, she developed a myopathy that predominantly affected her lower limbs. Histological studies of biopsied muscle revealed scattered atrophic myofibers with rimmed vacuoles that contained pigment granules. Histochemical staining revealed that the pigment comprised both iron and melanin, which is consistent with type II minocycline-induced cutaneous pigmentation. Under electron microscopy, autophagic vacuoles were consistently observed in association with numerous collections of pigment granules. Conclusions This is the first report of minocycline-induced pigmentation in skeletal muscle. The strong association between autophagic vacuoles and the accumulation of minocycline-induced pigments suggest that long-term minocycline treatment induced pigment accumulation, leading to elevation of autophagic activity and RVM. It might also be possible that minocycline directly activated autophagy, as the observed pigments are known to form complexes containing minocycline and/or its metabolites. As long-term minocycline treatment is expected to be used more widely in the future, we must draw attention to this adverse effect.

  4. Forward modeling of radio imaging (RIM) data with the Comsol RF module

    Science.gov (United States)

    Li, Yongxing; Smith, Richard S.

    2015-12-01

    Radio imaging method (RIM) is an electromagnetic (EM) tomographic method, which can be applied to image the electrical properties (principally the conductivity) in the plane defined by two boreholes. RIM employs the EM waves at radio frequencies between 100 kHz and 10 MHz, and the manner that these waves propagate around subsurface ore bodies has not been studied thoroughly. We studied the wave propagation using the finite element modeling (FEM) algorithm as implemented in the Comsol RF module. An appropriate element size is quantified by comparing the Comsol modeling results of 6 types of element sizes at 4 frequencies with the analytical solution in the homogeneous whole space. The FEM model data with 5 elements per wavelength have errors less than 5%; 7-8 elements per wavelength provide the errors around 1%; when there are 10 elements per wavelength, the errors are less than 1%. Comparison studies for more complicated models with anomalous conductivity structures show that the Comsol modeling results are consistent with results derived from analytical solutions, finite-difference time-domain methods and integral equations. To illustrate the flexibility of the Comsol method for RIM modeling, we provide an example with two moderately conductive bodies between boreholes. Receiver profiles and a relative variation map show that when the conductive bodies are two wavelengths away from the source, the EM wave attenuation and reflection by the conductive bodies can be observed. The amplitude tomography of the model data reveals that with the SIRT algorithm, the location of the conductive anomalies can be reconstructed successfully, although, some limitations exist such as low resolution, incorrect conductivity estimation, and some artifacts. From our work, we conclude that Comsol modeling is helpful to study radio wave propagation and imaging methods.

  5. Anterior versus posterior, and rim-rent rotator cuff tears: prevalence and MR sensitivity

    International Nuclear Information System (INIS)

    Purpose. To determine the relative distribution of the locations of rotator cuff tears, and the sensitivity of anterior versus posterior tears on MR images. Patients and methods. We identified 110 consecutive patients who had a shoulder MR and either a partial-thickness or a small full-thickness rotator cuff tear diagnosed at arthroscopy. MR sensitivity and patient age were compared between patients with tears in the anterior and posterior halves of the cuff. In addition, in patients with partial tears less than 2 cm in diameter, an age comparison between those with tears in the critical zone and those with articular surface tears adjacent to the bony insertion (rim-rent tear) was performed. Results. The tear was centered in the anterior half of the rotator cuff in 79% of the patients younger than 36 years old, and in 89% of the patients 36 years old and over. The average age of the patients with tears in the anterior half (44 years) was not significantly different from the average age of those with posterior tears (40 years). The sensitivity of MR for anterior tears was 0.69, and for posterior tears it was 0.56. Five of the nine rim-rent tears (0.56) were interpreted correctly on the original MR report; two of the other tears were misinterpreted as intratendinous fluid but were diagnosable in retrospect. Conclusion. Even in patients less than 36 years old, most partial and small full-thickness rotator cuff tears are centered in the anterior half of the supraspinatus. Although our figure for MR sensitivity for these tears is lower than in recent articles, we found no significant difference between the sensitivity of MR for diagnosing posterior tears versus tears in the anterior half of the supraspinatus tendon. Rim-rent tears can be mistaken for intratendinous signal, and should be carefully looked for in younger patients with shoulder pain. (orig.)

  6. The rim effect and other high-burnup modeling for NRC fuel performance codes

    International Nuclear Information System (INIS)

    The U.S. Nuclear Regulatory Commission (NRC) has recently initiated a new program to review data on the material properties of fuel and cladding at high burnup levels. The objective of this program is to update NRC fuel performance models within fuel performance codes to improve their predictive capability to rod-average burnup levels of 60 GWd/MTM. Models being reviewed for improvement at the higher burnup levels are fission gas release, fuel swelling, gap conductance, fuel thermal conductivity, pellet rim structure, radial power distribution, cladding corrosion/hydriding, and cladding mechanical properties

  7. Synthesis and characterization of partially substituted at lower rim phosphorus containing calix(4)arenes

    OpenAIRE

    2007-01-01

    Abstract Abstract: We report the synthesis and characterization of several new phosphorus-containing partially lower rim substituted derivatives of 5,11,17,23-tetra(t-butyl) calix(4)arene (I) and 5,11,17,23-tetra(t-octyl)calix(4)arene (II), namely 5,11,17,23-tetra(t-butyl)-25,27-dihydroxy-26,28-bis(diphenyl phosphinoyl-oxy) calix(4)arene (IV); 5,11,17,23-tetra(t-butyl)-25-hydroxy-26,27,28-tris(tetramethyldiamido-phosphinoyl-oxy) calix(4)arene (Vb); 5,11,17,23-tetra(t-butyl)-...

  8. Technical Efficiency and Port Competition: Revisiting the Bohai Economic Rim, China

    Directory of Open Access Journals (Sweden)

    Grace Wang

    2012-12-01

    Full Text Available The Bohai Economic Rim plays an important role in supporting China’s economic growth. For this research, we selected nine main ports in the region to study whether intra-port competition or corporatization would improve efficiency. Using a panel fixed effect model and stochastic frontier model, we found that the technical efficiency of selected ports is significantly influenced by the time of the initial public offering than by regional competition. The results are supportive and encouraging for policy makers to move toward the decentralized port governance in China.

  9. Ultratrace determination of the long-lived isotope 41Ca by narrowband CW-RIMS

    International Nuclear Information System (INIS)

    Determination of odd isotopes with multi-step RIMS is usually hampered by the hyperfine structure arising from a non zero nuclear spin. The splitting of the transition strength leads to a reduced ionization efficiency and large uncertainties in the determination of isotope ratios. We present a technique to overcome these drawbacks by appropriate use of optical pumping. Applying this technique, first isotopic ratio measurements on synthetic 41Ca-samples could be accomplished using double-resonance three photon ionization in a collimated atomic beam combined with a quadrupole mass spectrometer

  10. Radio continuum and molecular line observations of four bright-rimmed clouds

    OpenAIRE

    Urquhart, J. S.; Thompson, M. A.; Morgan, L.K.; White, Glenn J.

    2006-01-01

    Aims.To search for evidence of triggered star formation within four bright-rimmed clouds, SFO 58, SFO 68, SFO 75 and SFO 76. Methods: .We present the results of radio continuum and molecular line observations conducted using the Mopra millimetre-wave telescope and Australia Telescope Compact Array. We use the J=1{-}0 transitions of 12CO, 13CO and C18O to trace the distribution of molecular material and to study its kinematics. The radio continuum data is used to trace the distribution of t...

  11. Effects of Magnetic Field and FUV Radiation on the Structures of Bright-rimmed Clouds

    OpenAIRE

    Motoyama, Kazutaka; Umemoto, Tomofumi; Shang, Hsien; Hasegawa, Tatsuhiko

    2013-01-01

    The bright-rimmed cloud SFO 22 was observed with the 45 m telescope of Nobeyama Radio Observatory in the ^{12}CO (J = 1-0), ^{13}CO (J = 1-0), and C^{18}O (J = 1-0) lines, where well-developed head-tail structure and small line widths were found. Such features were predicted by radiation-driven implosion models, suggesting that SFO 22 may be in a quasi-stationary equilibrium state. We compare the observed properties with those from numerical models of a photo-evaporating clo...

  12. Collapse and expansion in the bright-rimmed cloud SFO 11NE

    OpenAIRE

    Thompson, M. A.; White, G. J.

    2004-01-01

    We report the results of a search for the double-peaked blue-skewed infall signature in the bright-rimmed cloud core SFO 11NE SMM1. Observations of the optically thick HCO$^{+}$ and optically thin H$^{13}$CO$^{+}$ J=3--2 lines reveal that there is indeed a characteristic double-peaked line profile, but skewed to the red rather than the blue. Modelling of the dust continuum emission and line profiles show that the motions within SFO 11NE SMM1 are consistent with a collapsing ...

  13. Numerical Simulation of Stresses in Thin-rimmed Spur Gears with Keyway

    OpenAIRE

    B. Br?žek; Leidich, E.

    2003-01-01

    This paper contains an investigation of the key on a stress distribution in a thin-rimmed spur gear. A stress analysis was carried out by means of the Finite Element Method (FEM). The 2D-FE analysis has helped to find the influence of turning the gearing towards the keyway on the stress in the loaded root of the tooth and in the keyway. 2D and 3D numerical analysis has been used to find mutual influence of every single notch (root of tooth and keyway), influence of thickness of the hub, lengt...

  14. A bright-rimmed cloud sculpted by the H ii region Sh2-48

    OpenAIRE

    Ortega, M. E.; Paron, S.; Giacani, E.; Rubio, M.; Dubner, G.

    2013-01-01

    To characterize a bright-rimmed cloud embedded in the HII region Sh2-48 searching for evidence of triggered star formation. We carried out observations towards a region of 2'x2' centered at RA=18h 22m 11.39s, dec.=-14deg 35m 24.81s (J2000) using the Atacama Submillimeter Telescope Experiment (ASTE; Chile) in the 12CO J=3-2,13CO J=3-2, HCO+ J=4-3, and CS J=7-6 lines with an angular resolution of about 22". We also present radio continuum observations at 5 GHz carried out with...

  15. Improvements in RIMS Isotopic Precision: Application to in situ atom-limited analyses

    International Nuclear Information System (INIS)

    Resonance ionization mass spectrometry offers high sensitivity and elemental selectivity in microanalysis, but the isotopic precision attainable by this technique has been limited. Here we report instrumental modifications to improve the precision of RIMS isotope ratio measurements. Special attention must be paid to eliminating pulse-to-pulse variations in the time-of-flight mass spectrometer through which the photoions travel, and resonant excitation schemes must be chosen such that the resonance transitions can substantially power-broadened to cover the isotope shifts. We report resonance ionization measurements of chromium isotope ratios with statistics-limited precision better than 1%.

  16. Neutron beam research in the Pacific Rim region - an Australian perspective

    International Nuclear Information System (INIS)

    A program of research in neutron scattering was established in Australia in the early 1960's, shortly after the reactor HIFAR commenced full power operation. The program has included elements of regional cooperation from the very early days. A report is given on the present status of australian neutron scattering research, and the activities (including several major new developments) in other Pacific Rim countries are briefly reviewed. Given the increasing sophistication of neutron scattering facilities and techniques, the case for regional cooperation is strongly advocated. 13 refs., 1 tab

  17. The stellar population and complex structure of the bright-rimmed cloud IC 1396N

    OpenAIRE

    Beltran, M. T.; Massi, F.; Lopez, R.; Girart, J. M.; Estalella, R.

    2009-01-01

    Context. IC 1396N is a bright-rimmed cloud associated with an intermediate-mass star-forming region, where a number of Herbig-Haro objects, H2 jet-like features, CO molecular outflows, and millimeter compact sources have been observed. Aims. To study in detail the complex structure of the IC 1396N core and the molecular outflows detected in the region and to reveal the presence of additional YSOs inside this globule. Methods. We carried out a deep survey of the IC 1396N regi...

  18. Improvements in RIMS isotope precision: applications to in situ atom-limited isotopic analysis

    International Nuclear Information System (INIS)

    Resonance ionization mass spectrometry offers high sensitivity and elemental selectivity in microanalysis, but the isotopic precision attainable by this technique has been limited. Here we report instrumental modifications to improve the precision of RIMS isotope ratio measurements. Special attention must be paid to eliminating pulse-to-pulse variations in the time-of-flight mass spectrometer through which the photoions travel, and resonant excitation schemes must be chosen such that the resonance transitions can be substantially power-broadened to cover the isotope shifts. We report resonance ionization measurements of chromium isotope ratios with statistics-limited precision better than 1%.

  19. H$_2$O maser emission from bright rimmed clouds in the northern hemisphere

    OpenAIRE

    Valdettaro, R.; Palla, F; Brand, J.; Cesaroni, R.

    2005-01-01

    We report the results of a multi-epoch survey of water maser observations at 22.2 GHz with the Medicina radiotelescope from 44 bright rimmed clouds (BRCs) of the northern hemisphere identified by Sugitani et al. (1989) as potential sites of star formation. The data span 16 years of observations and allow to draw conclusions about the maser detection rate in this class of objects. In spite of the relatively high far-infrared luminosities of the embedded sources ($L_{\\rm FIR}\\...

  20. Anterior versus posterior, and rim-rent rotator cuff tears: prevalence and MR sensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Tuite, M.J.; Turnbull, J.R.; Orwin, J.F. [Wisconsin Univ., Madison, WI (United States). Dept. of Radiology

    1998-05-01

    Purpose. To determine the relative distribution of the locations of rotator cuff tears, and the sensitivity of anterior versus posterior tears on MR images. Patients and methods. We identified 110 consecutive patients who had a shoulder MR and either a partial-thickness or a small full-thickness rotator cuff tear diagnosed at arthroscopy. From the arthroscopy videotapes, we classified the tears as centered in the anterior or posterior half of the cuff, and as either in the critical zone or adjacent to the bony insertion. The original MR interpretation was compared with the arthroscopic findings. MR sensitivity and patient age were compared between patients with tears in the anterior and posterior halves of the cuff. In addition, in patients with partial tears less than 2 cm in diameter, an age comparison between those with tears in the critical zone and those with articular surface tears adjacent to the bony insertion (rim-rent tear) was performed. Results. The tear was centered in the anterior half of the rotator cuff in 79% of the patients younger than 36 years old, and in 89% of the patients 36 years old and over. The average age of the patients with tears in the anterior half (44 years) was not significantly different from the average age of those with posterior tears (40 years)(P=0.23). The sensitivity of MR for anterior tears was 0.69, and for posterior tears it was 0.56 (P=0.17). The average age of the 9 patients with rim-rent tears was 31 years, while that of the 28 patients with similarly-sized partial tears not involving the insertion was 40 years old (P=0.048). Five of the nine rim-rent tears (0.56) were interpreted correctly on the original MR report; two of the other tears were misinterpreted as intratendinous fluid but were diagnosable in retrospect. Conclusion. Even in patients less than 36 years old, most partial and small full-thickness rotator cuff tears are centered in the anterior half of the supraspinatus. Although our figure for MR sensitivity for these tears is lower than in recent articles, we found no significant difference between the sensitivity of MR for diagnosing posterior tears versus tears in the anterior half of the supraspinatus tendon. Rim-rent tears can be mistaken for intratendinous signal, and should be carefully looked for in younger patients with shoulder pain. (orig.) With 5 figs., 2 tabs., 19 refs.

  1. Avaliação lectino-histoquímica de fígado e rim de ovinos com fotossensibilização causada por Brachiaria decumbens

    Directory of Open Access Journals (Sweden)

    Samay Z.R. Costa

    2013-08-01

    Full Text Available Embora sejam as forrageiras mais importantes para a pecuária de corte (bovinocultura de corte no Brasil, em certas épocas ou condições, Brachiaria spp. podem ser tóxicas e causar surtos de fotossensibilização hepatógena que determinam significativas perdas econômicas. Animais que se alimentam em pastos de Brachiaria spp. comumente apresentam macrófagos espumosos isolados ou agrupados, além de cristais no interior de ductos biliares. Saponinas esteroidais têm sido identificadas nestes cristais e são responsabilizadas por lesar o fígado levando ao acúmulo de filoeritrina. Por vezes, imagens negativas desses cristais podem estar presentes no citoplasma de macrófagos espumosos. A patogênese de formação e o tipo de material armazenado nas células espumosas ainda são desconhecidos. A técnica de lectino-histoquímica visa auxiliar na detecção desses macrófagos e, consequentemente, no diagnóstico, além de identificar quais os resíduos de açúcares específicos que estão presentes no citoplasma das células espumosas. Assim, este trabalho teve por objetivo identificar quais lectinas são mais indicadas na detecção de saponinas esteroidais no fígado e rim de ovinos com fotossensibilização causada por Brachiaria decumbens. Fragmentos de fígado e rim de quinze ovinos, de ambos os sexos e idade variável, oriundos de Conceição do Mato Dentro, Minas Gerais, e um ovino mantido em pastagem livre de Brachiaria spp. foram avaliados pela técnica de lectino-histoquímica. Quatorze lectinas foram utilizadas (Con-A, DBA, SBA, PNA, SJA, RCA-I, UEA-I, WGA, SWGA, GSL, PSA, PHA-L, PHA-E e LCA. Verificou-se que, no fígado de ovinos com fotossensibilização provocada pela ingestão de Brachiaria decumbens, a lectina PNA apresentou especificidade e acentuada reatividade aos macrófagos espumosos, bem como especificidade e leve reatividade aos hepatócitos; a lectina WGA teve especificidade e moderada reatividade aos macrófagos espumosos do fígado e especificidade e leve reatividade aos hepatócitos; e as lectinas SBA, GSL e LCA apresentaram especificidade e moderada reatividade aos macrófagos espumosos, entretanto, não foram específicas para hepatócitos. No rim dos ovinos, a lectina PNA foi a que apresentou maior reatividade. Avaliações lectino-histoquímicas ainda não haviam sido realizadas em fígado e rim de ovinos com fotossensibilização provocada por Brachiaria spp.

  2. Positron emission tracking of individual particles in particle-laden rimming flow

    Science.gov (United States)

    Denissenko, P.; Guyez, E.; Thomas, P. J.; Parker, D. J.; Seville, J. P. K.

    2014-05-01

    The motion of a single tracer particle in particle-laden rimming flows is investigated experimentally by means of Positron Emission Particle Tracking (PEPT). Semi-dilute suspensions, with a volume fraction of 8% of heavy particles are considered. The trajectory of the tracer particle is monitored for several thousand cylinder revolutions and related to the optically recorded drift of the large-scale granular segregation bands developing in the cylinder. Results of the data analysis provide first insights into the relation between behaviour of individual particles and the spatiotemporal dynamics displayed by the macroscopic particle-segregation patterns.

  3. Positron emission tracking of individual particles in particle-laden rimming flow

    International Nuclear Information System (INIS)

    The motion of a single tracer particle in particle-laden rimming flows is investigated experimentally by means of Positron Emission Particle Tracking (PEPT). Semi-dilute suspensions, with a volume fraction of 8% of heavy particles are considered. The trajectory of the tracer particle is monitored for several thousand cylinder revolutions and related to the optically recorded drift of the large-scale granular segregation bands developing in the cylinder. Results of the data analysis provide first insights into the relation between behaviour of individual particles and the spatiotemporal dynamics displayed by the macroscopic particle-segregation patterns

  4. Pathogenesis of myeloma bone disease.

    Science.gov (United States)

    Roodman, G David

    2010-02-01

    Multiple myeloma (MM) is the most common cancer to involve bone with up to 90% of patients developing bone lesions. The bone lesions are purely osteolytic in nature and do not heal in the vast majority of patients. Up to 60% of patients develop pathologic fractures over the course of their disease. Bone disease is a hallmark of MM, and myeloma bone disease differs from bone metastasis caused by other tumors. Although myeloma and other osteolytic metastases induce increased osteoclastic bone destruction, in contrast to other tumors, once myeloma tumor burden exceeds 50% in a local area, osteoblast activity is either severely depressed or absent. The basis for this severe imbalance between increased osteoclastic bone resorption and decreased bone formation has been the topic of intensive investigation over the last several years. These studies have helped to identify novel targets for treating myeloma bone disease and will be discussed in this chapter. PMID:20014067

  5. Targeted therapies for bone sarcomas

    OpenAIRE

    HEYMANN, Dominique; Rédini, Françoise

    2013-01-01

    Bone sarcomas include a very large number of tumour subtypes, which originate form bone and more particularly from mesenchymal stem cell lineage. Osteosarcoma, Ewing's sarcoma and chondrosarcoma, the three main bone sarcoma entities develop in a favourable microenvironment composed by bone cells, blood vessels, immune cells, based on the ‘seed and soil theory'. Current therapy associates surgery and chemotherapy, however, bone sarcomas remain diseases with high morbidity and mortality especia...

  6. Bone Metabolism in Anorexia Nervosa

    OpenAIRE

    Fazeli, Pouneh K.; Klibanski, Anne

    2014-01-01

    Anorexia nervosa (AN), a psychiatric disorder predominantly affecting young women, is characterized by self-imposed chronic nutritional deprivation and distorted body image. AN is associated with a number of medical co-morbidities including low bone mass. The low bone mass in AN is due to an uncoupling of bone formation and bone resorption, which is the result of hormonal adaptations aimed at decreasing energy expenditure during periods of low energy intake. Importantly, the low bone mass in ...

  7. Immunoregulation of bone remodelling

    Science.gov (United States)

    Singh, Ajai; Mehdi, Abbass A; Srivastava, Rajeshwer N; Verma, Nar Singh

    2012-01-01

    Remodeling, a continuous physiological process maintains the strength of the bones, which maintains a delicate balance between bone formation and resorption process. This review gives an insight to the complex interaction and correlation between the bone remodeling and the corresponding changes in host immunological environment and also summarises the most recent developments occuring in the understanding of this complex field. T cells, both directly and indirectly increase the expression of receptor activator of nuclear factor kB ligand (RANKL); a vital step in the activation of osteoclasts, thus positively regulates the osteoclastogenesis. Though various cytokines, chemikines, transcription factors and co-stimulatory molecules are shared by both skeletal and immune systems, but researches are being conducted to establish and analyse their role and / or control on this complex but vital process. The understanding of this part of research may open new horizons in the management of inflammatory and autoimmune diseases, resulting into bone loss and that of osteoporosis also. PMID:22837895

  8. Wormian bones: a review.

    Science.gov (United States)

    Bellary, Sharath S; Steinberg, Ashley; Mirzayan, Nadine; Shirak, Michelle; Tubbs, R Shane; Cohen-Gadol, Aaron A; Loukas, Marios

    2013-11-01

    Wormian bones are abnormal ossicles that develop from extra ossification centers within the cranium. They are most frequently located in the lambdoid suture or the coronal suture, and have been seen in the fontanelles, particularly the posterior fontanelle. It is unclear at this time exactly how or why they are formed, although genetic as well as environmental factors have been proposed. Their initial formation is thought to be caused by a degree of dural strain and increased sutural width. These conditions can result from mechanically induced stress due to intentional deformation like that practiced in ancient cultures, premature sutural closure, or from reduced skull ossification as seen in metabolic bone diseases. The cause of the malformation can have an influence on the number and location of Wormian bones. Clinically, Wormian bones are used as markers in the diagnoses of many autosomal dominant genetic disorders, namely, craniosynostosis and osteogenesis imperfecta. PMID:23959948

  9. Osteopetrosis (marble bone disease

    Directory of Open Access Journals (Sweden)

    Alexey Nikolayevich Kalyagin

    2014-03-01

    Full Text Available We report the data of the history of describing osteopetrosis (marble bone disease, its clinical features, diagnosis, and possible therapy approaches. Our own clinical case is presented.

  10. [Allergy towards bone cement].

    Science.gov (United States)

    Thomas, P; Schuh, A; Summer, B; Mazoochian, F; Thomsen, M

    2006-09-01

    Bone cements based on polymethylmethacrylate are typically used for fixation of artificial joints. Intolerance reactions to endoprostheses not explained by infection or mechanical failure may lead to allergological diagnostics, which mostly focuses on metal allergy. However, also bone cement components may provoke hypersensitivity reactions leading to eczema, implant loosening, or fistula formation. Elicitors of such reactions encompass acrylates and additives such as benzoyl peroxide, N,N-dimethyl-p-toluidine, hydroquinone, or antibiotics (particularly gentamicin). Upon repeated contact with bone cement components, e.g., acrylate monomers, also in medical personnel occasionally hand eczema or even asthma may develop. Therefore, in the case of suspected hypersensitivity reactions to arthroplasty, the allergological diagnostics should include bone cement components. PMID:16865384

  11. Skeletal Scintigraphy (Bone Scan)

    Science.gov (United States)

    ... placed over the patient's body. SPECT involves the rotation of the gamma camera heads around the patient's ... that has spread to the bones from other parts of the body. Scintigraphy can detect osteomyelitis , an ...

  12. A ceramic/slag interface as an analog for accretion of hot refractory objects and rim formation

    Science.gov (United States)

    Paque, J. M.; Bunch, T. E.

    1994-01-01

    Refractory inclusions or Ca-Al-rich inclusions (CAI's) from carbonaceous chondrites span a wide range of bulk compositions that cannot be explained either by segregation from a gas of solar composition at different points in the condensation sequence or by fractional crystallization from a parent liquid. CAI's are commonly rimmed by Wark-Lovering (W-L) rims, a series of nearly monomineralic layers that have been a source of controversy since the variety of rim sequences occurring on different types of CAI's from Allende were described. The origin of these distinctive features has not yet been resolved, with proponents of accretion, condensation, flash heating, ablation, evaporation, etc. Rims have generated considerable interest because they potentially contain clues to conditions experienced by CAI's after the formation of the inclusion and prior to incorporation into the parent body. Ceramic bricks in contact with hot steel slag may produce reaction products in rimlike fashion similar to those found in CAI's. The similarity between the mineralogy of blast furnace slags and CAI's has long been recognized, with both containing unusual phases not found in terrestrial materials. We provide here a comparison between a ceramic brick/slag multiple-layered interface and a multiple-layered interface between a melilite-perovskite object and a melilite-spinel object in the Allende inclusion USNM 4691-1. These results have implications in interpreting the origin of rims and the textures and compositions of CAI's.

  13. Cardiovascular drugs and bone

    DEFF Research Database (Denmark)

    Rejnmark, Lars

    2008-01-01

    Cardiovascular diseases are common and occur mainly in the elderly in whom osteoporotic fractures also are very common. Because of this, it is of importance to establish whether drugs used in the treatment of cardiovascular diseases affect bone, in order to minimise any possible adverse effects. In the majority of studies, treatment with thiazide diuretics, statins, digoxin, angiotensin-converting enzyme (ACE)-inhibitors, and organic nitrates have not been associated with harmful effects on bone...

  14. Bone Healing: Little Secrets

    OpenAIRE

    Einhorn, T.A.

    2010-01-01

    The development of new strategies to enhance the healing of fractures continues to evolve with the introduction of both locally and systemically delivered compounds. The recent refinement in the use of autologous bone marrow as a bone graft material has brought the field of stem cell biology into orthopaedic practice. New recombinant peptides such as platelet- derived growth factor and teriparatide show promise as local and systemic enhancers respectively. Finally, recent evidence that mutati...

  15. Radiotherapy for bone pain.

    OpenAIRE

    Needham, P. R.; Mithal, N P; Hoskin, P J

    1994-01-01

    Painful bone metastases are a common problem for cancer patients. Although current evidence supports the use of a single fraction of radiotherapy as the treatment of choice, many radiotherapists, for a variety of reasons, continue to use fractionated regimens. Over one six month period 105 patients received external beam irradiation for painful bone metastases at the Royal London Hospital (RLH). Thirty-one per cent of the patients were aged 70 or over. The treatment of 97 of these patients wa...

  16. Diffuse lymphangiomatosis of bone

    International Nuclear Information System (INIS)

    Two cases of lymphangiomatosis of bone, a very rare systemic condition characterised by both skeletal and parenchymal lesions, are presented. The skeletal changes have an appearance similar to haemangiomas in the spine, and soap-bubbly lesions in the flat bones. One case carried the diagnosis of eosinophilic granuloma for 18 years. The findings on MRI, which have not been previously well-established, are discussed. Copyright (1999) Blackwell Science Pty Ltd

  17. [Accumulation of microdamage and bone quality].

    Science.gov (United States)

    Mashiba, Tasuku

    2005-06-01

    Quantification of accumulated microdamage in bone is one of evaluation methods of bone quality. Microdamage accumulation in bone reduces some tissue material property of bone. However, microdamage is also closely associated with bone metabolism and mechanical environment of bone, and functions as accelerator of bone turnover through the detection and repair of damage. PMID:15930703

  18. Bone formation: roles of genistein and daidzein

    Science.gov (United States)

    Bone remodeling consists of a balance between bone formation by osteoblasts and bone resorption by osteoclasts. Osteoporosis is the result of increased bone resorption and decreased bone formation causing a decreased bone mass density, loss of bone microarchitecture, and an increased risk of fractu...

  19. Bone nutrients for vegetarians.

    Science.gov (United States)

    Mangels, Ann Reed

    2014-07-01

    The process of bone mineralization and resorption is complex and is affected by numerous factors, including dietary constituents. Although some dietary factors involved in bone health, such as calcium and vitamin D, are typically associated with dairy products, plant-based sources of these nutrients also supply other key nutrients involved in bone maintenance. Some research suggests that vegetarian diets, especially vegan diets, are associated with lower bone mineral density (BMD), but this does not appear to be clinically significant. Vegan diets are not associated with an increased fracture risk if calcium intake is adequate. Dietary factors in plant-based diets that support the development and maintenance of bone mass include calcium, vitamin D, protein, potassium, and soy isoflavones. Other factors present in plant-based diets such as oxalic acid and phytic acid can potentially interfere with absorption and retention of calcium and thereby have a negative effect on BMD. Impaired vitamin B-12 status also negatively affects BMD. The role of protein in calcium balance is multifaceted. Overall, calcium and protein intakes in accord with Dietary Reference Intakes are recommended for vegetarians, including vegans. Fortified foods are often helpful in meeting recommendations for calcium and vitamin D. Plant-based diets can provide adequate amounts of key nutrients for bone health. PMID:24898231

  20. The obesity of bone

    Science.gov (United States)

    Greco, Emanuela A.; Lenzi, Andrea; Migliaccio, Silvia

    2015-01-01

    During the last decades, obesity and osteoporosis have become important global health problems, and the belief that obesity is protective against osteoporosis has recently come into question. In fact, some recent epidemiologic and clinical studies have shown that a high level of fat mass might be a risk factor for osteoporosis and fragility fractures. Several potential mechanisms have been proposed to explain the complex relationship between adipose tissue and bone. Indeed, adipose tissue secretes various molecules, named adipokines, which are thought to have effects on metabolic, skeletal and cardiovascular systems. Moreover, fat tissue is one of the major sources of aromatase, an enzyme that synthesizes estrogens from androgen precursors, hormones that play a pivotal role in the maintenance of skeletal homeostasis, protecting against osteoporosis. Moreover, bone cells express several specific hormone receptors and recent observations have shown that bone-derived factors, such as osteocalcin and osteopontin, affect body weight control and glucose homeostasis. Thus, the skeleton is considered an endocrine target organ and an endocrine organ itself, likely influencing other organs as well. Finally, adipocytes and osteoblasts originate from a common progenitor, a pluripotential mesenchymal stem cell, which has an equal propensity for differentiation into adipocytes or osteoblasts (or other lines) under the influence of several cell-derived transcription factors. This review will highlight recent insights into the relationship between fat and bone, evaluating both potential positive and negative influences between adipose and bone tissue. It will also focus on the hypothesis that osteoporosis might be considered the obesity of bone. PMID:26623005

  1. Bone scintigraphy in children

    International Nuclear Information System (INIS)

    Full text: Bone scintigraphy is an integral part of the evaluation of bone disease in children. Common indications are suspected infection or inflammation, bone tumours and metastases, trauma and avascular necrosis. In all these disorders the sensitivity of scintigraphy is high. Gallium scintigraphy is often useful in children with clinical signs of infection not responding to treatment but the radiation dose is high. High quality images are essential. They depend on the full participation and co-operation of the child, parents and radiographers, the administration of appropriate analgesics, gentle but firm handling of the child, the injection of the appropriate amount of radiopharmaceutical, good positioning and immobilization, optimised equipment, and the acquisition of a suitable number of counts in an appropriate matrix size. Unless there are specific reasons for not doing so, we routinely perform two phase bone scintigraphy. This usually involves whole body blood pool and delayed images followed by static images of selected areas and, less often, pinhole images or SPECT. The interpretation of bone scan images in children requires knowledge of the age dependent differences in bone metabolism in the developing skeleton and the effect on the appearance of the maturing skeleton. (author)

  2. Crosstalk between cancer cells and bone microenvironment in bone metastasis

    International Nuclear Information System (INIS)

    Bone, as well as lung and liver, is one of the most preferential metastatic target sites for cancers including breast, prostate, and lung cancers. Although the precise molecular mechanisms underlying this preference need to be elucidated, it appears that bone microenvironments possess unique biological features that enable circulating cancer cells to home, survive and proliferate, and destroy bone. In conjunction, cancers that develop bone metastases likely have the capacity to utilize these unique bone environments for colonization and bone destruction. This crosstalk between metastatic cancer cells and bone is critical to the development and progression of bone metastases. Disruption of this interaction will allow us to design mechanism-based effective and specific therapeutic interventions for bone metastases

  3. Can bone scintigraphy predict the final outcome of pasteurized autografts?

    Energy Technology Data Exchange (ETDEWEB)

    Eid, Ahmed Shawky [Ain Shams University, Department of Orthopedic Surgery, Cairo (Egypt); Jeon, Dae-Geun; Cho, Wan Hyeong [Korea Cancer Center Hospital, Department of Orthopedic Surgery, Seoul (Korea)

    2010-10-15

    As pasteurization is becoming more widely used in limb salvage reconstruction, more study is required to understand about host-graft junction healing, graft revascularization and incorporation, and the incidence and type of complications among pasteurized autografts. This was mainly achieved by follow-up radiography. We aimed to clarify whether Tc99m bone scanning can be considered a reliable method in determining these three parameters. Twenty-seven osteosarcoma patients with pasteurized autograft reconstructions were retrospectively reviewed using available scintigraphic and radiographic follow-up every 6 months postoperatively for 36 months. Follow-up of the unhealed cases was continued for the maximum follow-up period available for each case beyond the original study period, ranging from 1 to 15 months. Tc99m uptake was classified as cold, faint, moderate and high uptake. Junction healing was classified as none, partial and complete healing. Seventy percent of junctions united with a mean of 22 months. Ninety to 100% of junctions showed increased uptake (high or moderate) at one time of the study regardless of final outcome. 85% of the pasteurized grafts showed the characteristic ''tramline appearance''. Four grafts (15%) were complicated: pseudoarthrosis and implant failure (1), fractured plate (1), intramedullary nail (IMN) fracture (1), and prosthesis stem loosening in the host bone (1), with underlying unhealed junctions in all cases. Bone scanning can determine the stages of the graft's rim revascularization and incorporation; however, it cannot detect or predict junction healing or occurrence of complications. Supplementary treatment of unhealed junctions showing either decreased junctional uptake or graft quiescence may be warranted. Otherwise, detection of distant metastasis and early local recurrence remains the main application of Tc99m scanning in the management of bone sarcomas. (orig.)

  4. Bone Mineral Density Value Dependence on Bone Width

    Directory of Open Access Journals (Sweden)

    M. Mokhtari-Dizaji

    2006-05-01

    Full Text Available Dual x-ray absorptiometry (DXA is the most widely used measurement for the assessment of bone mass in osteoporosis. In clinical measurement, bone width can affect bone mineral parameters. The purpose of this study was to examine the dependence of bone mineral pa-rameters on bone width. In this study, DXA measurements were conducted on rabbit bone in vivo using clinical instruments. We have selected rabbit’s bones that have low BMD and more collagen tissue to predict structure not only measures BMD, but is also sensitive to the structure of the bone. To investigate the effect of bone width on the measured parameters, three regions of femur and tibia bones (N=132 were processed: upper (1/3 of length, middle (1/2 of length and lower (2/3 of length for BMC, areal BMD and volumetric BMD. The ANOVA analysis of bone mineral extracted by DXA showed significant differences (P<0.05 between BMC, BMDa and BMDv of six groups of upper, middle and lower parts of the femur and the tibia. It shows that BMC and BMD correlate well with the bone width, but BMDv inversely correlates with bone width. Linear and nonlinear regression analyses were used to examine the relationship between DXA characteristics with bone width and the regression function for each parameter is given. We concluded that BMC, areal BMD, and volumetric BMD in rabbit's bone with collagen fibers more than bone mineral are dependent on bone width. This result may be at least in part due to large precision error measurement of the bone width, in vivo.

  5. A Radio and Mid-Infrared Survey of Northern Bright-Rimmed Clouds

    CERN Document Server

    Morgan, L K; Urquhart, J S; Miao, G J; Miao, Glenn.J.White & J.

    2001-01-01

    We have carried out an archival radio, optical and infrared wavelength imaging survey of 44 Bright-Rimmed Clouds (BRCs) using the NRAO/VLA Sky Survey (NVSS) archive, images from the Digitised Sky Survey (DSS) and the Midcourse Space eXperiment (MSX). The data characterise the physical properties of the Ionised Boundary Layer (IBL) of the BRCs. A total of 25 clouds display 20 cm radio continuum emission that is associated with their bright optical rims. The ionising photon flux illuminating these clouds, the ionised gas pressure and the electron density of the IBL are determined. We derive internal molecular pressures for 9 clouds using molecular line data from the literature and compare these pressures to the IBL pressures to determine the pressure balance of the clouds. We find three clouds in which the pressure exerted by their IBLs is much greater than that measured in the internal molecular material. A comparison of external pressures around the remaining clouds to a global mean internal pressure shows th...

  6. Ultratrace analysis of plutonium in environmental samples by resonance ionization mass spectrometry (RIMS)

    International Nuclear Information System (INIS)

    Plutonium is present in the environment mainly as a result of global fallout from nuclear weapons tests, satellite and reactor accidents as well as releases from nuclear facilities. Sensitive and fast detection methods are required for risk assessment, low-level surveillance of the environment, personnel dose monitoring, studies of biological effects and investigations of the migration behavior of plutonium. Furthermore, the isotopic composition is of interest to get information from what source the plutonium contamination originated. Alpha-spectroscopy is most frequently used for the determination of trace amounts of plutonium in the environment with the disadvantage that the detection sensitivity depends on the half-life of the isotope to be measured and that there are limitations in the isotopic resolution. Conventional mass spectrometry may suffer from isobaric interferences. Therefore, in the last years resonant laser ionization mass spectrometry (RIMS) has been explored as an alternative for ultratrace analysis of plutonium. This method provides a high element and isotope selectivity and a good overall efficiency, resulting in a detection limit of ?106 atoms (?0.4 fg). RIMS meets also the requirements of a low background and a short measuring time (1-2 h)

  7. A bright-rimmed cloud sculpted by the H ii region Sh2-48

    CERN Document Server

    Ortega, M E; Giacani, E; Rubio, M; Dubner, G

    2013-01-01

    To characterize a bright-rimmed cloud embedded in the HII region Sh2-48 searching for evidence of triggered star formation. We carried out observations towards a region of 2'x2' centered at RA=18h 22m 11.39s, dec.=-14deg 35m 24.81s (J2000) using the Atacama Submillimeter Telescope Experiment (ASTE; Chile) in the 12CO J=3-2,13CO J=3-2, HCO+ J=4-3, and CS J=7-6 lines with an angular resolution of about 22". We also present radio continuum observations at 5 GHz carried out with the Jansky Very Large Array (JVLA; EEUU) interferometer with a synthetized beam of 7"x5". The analysis of our molecular observations reveals the presence of a relatively dense clump with n(H_2)~3x10^3 cm^-3, located in projection onto the interior of the HII region Sh2-48. The emission distribution of the four observed molecular transitions has, at VLSR~38 kms^-1, morphological anti-correlation with the bright-rimmed cloud as seen in the optical emission. From the new radio continuum observations we identify a thin layer of ionized gas lo...

  8. Characterization/Selection of a Continuous Wave Laser for RIMS Analysis in Nuclear Forensics

    Science.gov (United States)

    Lau, Sunny; Alves, F.; Karunasiri, G.; Smith, C.; Isselhardt, B.

    2015-03-01

    The effort to implement the technology of resonance ionization mass spectroscopy (RIMS) to problems of nuclear forensics involves the use of multiple lasers to selectively ionize the elements of concern. While current systems incorporate pulsed lasers, we present the results of a feasibility study to determine alternative (Continuous Wave) laser technologies to be employed for analysis of the actinides and fission products of debris from a nuclear detonation. RIMS has the potential to provide rapid isotope ratio quantification of the actinides and important fission products for post detonation nuclear forensics. The current approach to ionize uranium and plutonium uses three Ti-Sapphire pulsed lasers capable of a fundamental wavelength range of 700-1000 nm. In this work, we describe the use of a COTS CW laser to replace one of the pulsed lasers used for the second resonance excitation step of plutonium near 847.282 nm. We characterize the critical laser parameters necessary to achieve high precision isotope ratio measurements including the stability over time of the mean wavelength, bandwidth and spectral mode purity. This far narrower bandwidth laser provides a simpler setup, more robust hardware (greater mobility), and more efficient use of laser irradiance.

  9. SURGICAL SITE INFECTIONS: A STUDY OF INCIDENCE, RISK FACTORS & ANTIMICROBIAL SENSITIVITY AT RIMS, KADAPA, A. P.

    Directory of Open Access Journals (Sweden)

    Giridhar

    2015-08-01

    Full Text Available S urgical site infection is the most common complication following surgical procedures. The aim of the study is to determine the incidence, associated risk factors and antimicrobial sensitivity pattern at RIMS, KADAPA. MATERIALS AND METHODS: This is a prospective study carried at surgical wards of RIMS KADAPA from Jan. 2015 to June 2015. All the patients were followed for 30 days for development of surgical site infection. Infected cases were identified u sing CDC, criteria. All the data are expressed in percentage. RESULTS : The overall prevalence of surgical site infection is 19%. The incidence was more common in age group above 40 years. The risk factors associated with SSI are long stay in hospital (14% , abdominal surgeries, long duration of surgery, and diabetes. The most common organism isolated is Staphylococcus aureus (30%. CONCLUSION: Surgical site infection is most common following surgery. Significant determinants are long stay in the ward, abdomi nal surgeries, emergency surgeries and diabetes. Effective infection control measures and good regular surveillance will improve the SSI rate to an acceptable level.

  10. The GT-MHR - clear, economic, and safe power for the Pacific Rim

    International Nuclear Information System (INIS)

    In recent decades the nations of the Pacific Rim have outpaced the rest of the world in economic growth. Beyond an abundant labor market and the region's natural resources, energy has played a pivotal role in fuelling this boom. The diverse sources of this energy largely reflect the naturally occurring fuel assets in the Rim countries. Only in the countries where these resources are less plentiful has nuclear energy become a significant sources of electric power generation. Persuasive as the argument for non-polluting power may be by itself it does not sell the nuclear energy option. In addition to being clean it must also be economically competitive and very safe. The authors claim that the Gas-Turbine Modular Helium Reactor (GT-MHR) is an advances nuclear power system that addresses the issues, and should be viewed as an attractive candidate to meet future energy needs. The GT-MHR derives from the coupling of a small, passively safe, modular reactor directly with a compact power conversion module. It uses the Brayton cycle to produce electricity directly with the primary helium coolant driving the turbine-generator. Thus, it shows promise for a quantum reduction in power generation costs by increasing plant efficiency to a remarkable 48% This paper highlights the advantages of the fact that the design is based on proven technology, and offers a clean, economic and safe energy for electricity and high temperature process heat. 2 refs., 4 figs

  11. Analysis of physical processes affecting restructuring of UO2 fuel in Rim-zone

    International Nuclear Information System (INIS)

    The purpose of the presented paper is the analysis of the processes affecting so-called 'rim-zone' formation in UO2 and the development of the model describing isotope content profiles at extended burnup. The influence of rim-zone and extended burnup on fuel temperatures is also considered. A brief review of the worldwide models for fission rate and isotope content profiles at extended burnup is given. In this frame, a new model for for prediction of radial profiles of burnup, fission rate and plutonium isotopes have been developed in the TRINITY (Russia). The results from the comparison of the model predictions with experimental data show that the model has good predictability. A new model describing the conditions of dislocation loop nucleation from interstitial atom clusters on fission spikes is also proposed in this paper. The results of the model show that the fuel grain diameter significantly affects the concentration of point defects and dislocation loops. The paper presents the results from the RTOP code calculations of fuel temperature, taking into account non-uniform fission rate and thermal conductivity degradation as result of burnup increasing

  12. Liprin-?2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.

    Science.gov (United States)

    Spangler, Samantha A; Schmitz, Sabine K; Kevenaar, Josta T; de Graaff, Esther; de Wit, Heidi; Demmers, Jeroen; Toonen, Ruud F; Hoogenraad, Casper C

    2013-06-10

    The presynaptic active zone mediates synaptic vesicle exocytosis, and modulation of its molecular composition is important for many types of synaptic plasticity. Here, we identify synaptic scaffold protein liprin-?2 as a key organizer in this process. We show that liprin-?2 levels were regulated by synaptic activity and the ubiquitin-proteasome system. Furthermore, liprin-?2 organized presynaptic ultrastructure and controlled synaptic output by regulating synaptic vesicle pool size. The presence of liprin-?2 at presynaptic sites did not depend on other active zone scaffolding proteins but was critical for recruitment of several components of the release machinery, including RIM1 and CASK. Fluorescence recovery after photobleaching showed that depletion of liprin-?2 resulted in reduced turnover of RIM1 and CASK at presynaptic terminals, suggesting that liprin-?2 promotes dynamic scaffolding for molecular complexes that facilitate synaptic vesicle release. Therefore, liprin-?2 plays an important role in maintaining active zone dynamics to modulate synaptic efficacy in response to changes in network activity. PMID:23751498

  13. Definition imaging of an orebody with the radio imaging method (RIM)

    International Nuclear Information System (INIS)

    Waste rock dilution is an economic concern in the planning and design of mining methods for mineralized ore zones. Diamond core drilling and mineralogical examination of core are routinely used to determine the general shape of the ore body. Drilling on closer centers enhances the definition of the mineralization and oregrade across the orebody. In a practical sense, drilling time and cost limit definition. Crosshole scanning between drillholes with the radio imaging method (RIM) has been used to map changes in mineralization in the rock mass. The magnitude and phase of the RIM radio wave depend on the electrical conductivity of the rock mass. The conductivity strongly depends on the percent mineralization. Since the attenuation rate and phase constants of the radio wave are proportional to the one half power of conductivity, the measured crosshole radio wave data can be processed in a tomography algorithm to reconstruct images (map the change in conductivity (mineralization)). The tomography image enhances definition in the orebody while reducing the number of drillholes. This paper compares reconstructed images of the radio wave propagation constants to percent mineralization in the ore body

  14. Glicolipoproteína de Leptospira interrogans sorogrupo icterohaemorrhagiae: distribuição em fígado e rim de cobaias experimentalmente infectadas

    Directory of Open Access Journals (Sweden)

    R.T. Macêdo Santos

    1989-08-01

    Full Text Available Acredita-se que as lesões teciduais na leptospirose possam decorrer da ação direta das leptospiras, de toxinas sintetizadas ou liberadas durante sua lise. O presente estudo visou a extração quimica da glicolipoproteína (GLP da leptospira, a produção de anti-soro anti-GLP e a avaliação de sua distribuição em cortes de fígado e rim de cobaias inoculadas e sacrificadas em estudo seqüencial diário até o 6°dia de infecção, correspondente ao pico da doença. Procurou-se também correlacionar a expressão tecidual da GLP com o grau de lesões locais, em busca de novos subsídios para a compreensão da patogenia da leptospirose. A QLP foi detectada em fígado e rim de 2 dentre 6 cobaias no 5°dia e em todas as 6 no 6° dia de infecção, sob a forma de grânulos no citoplasma de macrófagos, livres no interstício ou acolados à membrana de células endoteliais e parenquimatosas, especialmente nas regiões mais lesadas. A cronologia do aparecimento da GLP e sua distribuição sugerem tratar-se de produto dc lise de leptospiras fagocitadas por macrófagos e que esta substância, conquanto não comprovada como iniciadora das lesões, associa-se a seu agravamento nas etapas mais avançadas da leptospirose.

  15. Mimicking the nanostructure of bone matrix to regenerate bone

    Directory of Open Access Journals (Sweden)

    Robert Kane

    2013-11-01

    Full Text Available Key features of bone tissue structure and composition are capable of directing cellular behavior toward the generation of new bone tissue. Bone tissue, as well as materials derived from bone, have a long and successful history of use as bone grafting materials. Recent developments in design and processing of synthetic scaffolding systems has allowed the replication of the bone's desirable biological activity in easy to fabricate polymeric materials with nano-scale features exposed on the surface. The biological response to these new tissue-engineering scaffold materials oftentimes exceeds that seen on scaffolds produced using biological materials.

  16. Bone scintigraphy of decompression sickness

    International Nuclear Information System (INIS)

    Value of bone scintigraphy in decompression sickness of 42 patients was retrospectively evaluated. Bone scintigraphy was positive in 30 of 42 patients (83 lesions), while radiography and symptoms were positive in 23 patients (48 lesions), and in 29 patients (44 lesions) respectively. Bone scintigraphy was positive in many lesions with negative radiography or symptoms. However, approximately half of the lesions in which either radiography or symptoms was positive could not be detected by bone scintigraphy. These cases mostly showed radiographic abnormalities such as irregular calcified areas and ''bone island'' in the cervical regions of the humerus, femur and tibia. Both bone scintigraphy and radiography were positive in most of the patients with symptoms of the bends and there seems to be a close relationship between the bends symptoms and bone lesion. We concluded that bone scintigraphy is useful for the evaluation of decompression sickness, but it must be complemented by bone radiography to avoid a significant number of false negative cases. (author)

  17. Quantitative analysis of hyperintensity rim sign surrounding MS plaque on T1 weighted images. Comparison with lacunar infarction

    International Nuclear Information System (INIS)

    This study evaluated the incidence of MR findings showing a hyperintensity rim surrounding multiple sclerosis (MS) plaque on T1-weighted images using image analysis software. We also evaluate the efficacy of this MR finding for differentiating between MS and lacunar infarction. We reviewed T1-weighted images in clinically diagnosed MS patients who underwent MR imaging between February 2006 and July 2007. Two hundred and thirty-nine nodular low signal intensities over 5 mm in minimal diameter were observed in 39 MS patients. To compare the incidence of MR findings, we also reviewed T1-weighted images in randomly selected lacunar infarction patients who underwent MR imaging during the same period. There were 51 nodular low signal intensities over 5 mm in shortest diameter in 34 lacunar infarction patients. After standardization of MR images, we calculated each signal intensity at the plaque margin (M.I.) and surrounding white matter (Wh.I.) using plot-profile analysis. We judged that hyperintensity rim sign was positive when the M.I/Wh.I. ratio was over 1.05. Among 239 T1 low intensity plaques in 39 MS patients, hyperintensity rim sign was positive for 81 (33.9%) plaques in 21 (53.8%) patients. Among 51 T1 low intensity lesions in 34 lacunar infarction patients, hyperintensity rim sign was positive for only one lesion in one patient. There were significant differences in the incidence of hyperintensity rim sign between the two patients groups (p<0.0001). On quantitative analysis using imaging standardization and plot-profile analysis, hyperintensity rim sign was observed in one-third of T1 low intensity MS plaques. This finding seems to be useful to differentiate multiple sclerosis from lacunar infarction. (author)

  18. Gene Expression in Bone

    Science.gov (United States)

    D'Ambrogio, A.

    Skeletal system has two main functions, to provide mechanical integrity for both locomotion and protection and to play an important role in mineral homeostasis. There is extensive evidence showing loss of bone mass during long-term Space-Flights. The loss is due to a break in the equilibrium between the activity of osteoblasts (the cells that forms bone) and the activity of osteoclasts (the cells that resorbs bone). Surprisingly, there is scanty information about the possible altered gene expression occurring in cells that form bone in microgravity.(Just 69 articles result from a "gene expression in microgravity" MedLine query.) Gene-chip or microarray technology allows to screen thousands of genes at the same time: the use of this technology on samples coming from cells exposed to microgravity could provide us with many important informations. For example, the identification of the molecules or structures which are the first sensors of the mechanical stress derived from lack of gravity, could help in understanding which is the first event leading to bone loss due to long-term exposure to microgravity. Consequently, this structure could become a target for a custom-designed drug. It is evident that bone mass loss, observed during long-time stay in Space, represents an accelerated model of what happens in aging osteoporosis. Therefore, the discovery and design of drugs able to interfere with the bone-loss process, could help also in preventing negative physiological processes normally observed on Earth. Considering the aims stated above, my research is designed to:

  19. Bone scan in pediatrics

    International Nuclear Information System (INIS)

    In 1984, a survey carried out in 21 countries in Europe showed that bone scintigraphy comprised 16% of all paediatric radioisotope scans. Although the value of bone scans in paediatrics is potentially great, their quality varies greatly, and poor-quality images are giving this valuable technique a bad reputation. The handling of children requires a sensitive staff and the provision of a few simple inexpensive items of distraction. Attempting simply to scan a child between two adult patients in a busy general department is a recipe for an unhappy, uncooperative child with the probable result of poor images. The intravenous injection of isotope should be given adjacent to the gamma camera room, unless dynamic scans are required, so that the child does not associate the camera with the injection. This injection is best carried out by someone competent in paediatric venipunture; the entire procedure should be explained to the child and parent, who should remain with child throughout. It is naive to think that silence makes for a cooperative child. The sensitivity of bone-seeking radioisotope tracers and the marked improvement in gamma camera resolution has allowed the bone scanning to become an integrated technique in the assessment of children suspected of suffering from pathological bone conditions. The tracer most commonly used for routine bone scanning is 99mTc diphosphonate (MDP); other isotopes used include 99mTc colloid for bone marrow scans and 67Ga citrate and 111In white blood cells (111In WBC) for investigation of inflammatory/infective lesions

  20. Osteoma osteoide no osso ilíaco: relato de dois casos / Osteoid osteoma in the iliac bone: report on two cases

    Scientific Electronic Library Online (English)

    Elmano de Araújo, Loures; Bruno Fajardo do, Nascimento; Marcelo de Carvalho, Amorim; Clarice Naya, Loures.

    2012-04-01

    Full Text Available O osteoma osteoide é um tumor benigno do osso que se apresenta geralmente com dor noturna em adultos jovens, aliviada por repouso e salicilatos. Pode acometer qualquer osso, mas sua ocorrência no ilíaco é infrequente. Os autores descrevem dois casos de osteoma osteoide intramedular, localizado junto [...] à articulação sacroilíaca, com sintomas que simulavam dor ciática e cujo diagnóstico se deu de forma tardia, apesar de o exame radiológico inicial mostrar lesão esclerótica em ambos os casos. O diagnóstico foi ratificado por tomografia computadorizada e o tratamento proposto foi a ressecção em bloco da lesão, com excisão do nidus. O diagnóstico definitivo foi confirmado pelo exame histopatológico. No seguimento de longo prazo, ambos estão assintomáticos e observou-se completa remodelação óssea no sítio cirúrgico. Os autores enfatizam as características típicas do tumor, a localização não usual, o diagnóstico diferencial e o tratamento. Abstract in english Osteoid osteoma is a benign bone tumor that generally presents with nighttime pain among young adults and is relieved by rest and salicylates. It can affect any bone, but occurrences in the iliac are unusual. The authors describe two cases of intramedullary osteoid osteoma next to the sacroiliac joi [...] nt, with symptoms that simulated sciatic pain. The cases were diagnosed late, although the initial radiographs showed sclerotic lesions in both cases. The diagnosis was confirmed by means of CT scan and the nidus was excised surgically through en bloc resection. The definitive diagnosis was given by means of histopathological examination. Over long-term follow-up, both cases remained asymptomatic and complete bone remodeling at the surgical site was observed. The authors highlight the typical characteristics of the tumor, the unusual location, the differential diagnosis and the treatment.

  1. Osteoma osteoide no osso ilíaco: relato de dois casos Osteoid osteoma in the iliac bone: report on two cases

    Directory of Open Access Journals (Sweden)

    Elmano de Araújo Loures

    2012-04-01

    Full Text Available O osteoma osteoide é um tumor benigno do osso que se apresenta geralmente com dor noturna em adultos jovens, aliviada por repouso e salicilatos. Pode acometer qualquer osso, mas sua ocorrência no ilíaco é infrequente. Os autores descrevem dois casos de osteoma osteoide intramedular, localizado junto à articulação sacroilíaca, com sintomas que simulavam dor ciática e cujo diagnóstico se deu de forma tardia, apesar de o exame radiológico inicial mostrar lesão esclerótica em ambos os casos. O diagnóstico foi ratificado por tomografia computadorizada e o tratamento proposto foi a ressecção em bloco da lesão, com excisão do nidus. O diagnóstico definitivo foi confirmado pelo exame histopatológico. No seguimento de longo prazo, ambos estão assintomáticos e observou-se completa remodelação óssea no sítio cirúrgico. Os autores enfatizam as características típicas do tumor, a localização não usual, o diagnóstico diferencial e o tratamento.Osteoid osteoma is a benign bone tumor that generally presents with nighttime pain among young adults and is relieved by rest and salicylates. It can affect any bone, but occurrences in the iliac are unusual. The authors describe two cases of intramedullary osteoid osteoma next to the sacroiliac joint, with symptoms that simulated sciatic pain. The cases were diagnosed late, although the initial radiographs showed sclerotic lesions in both cases. The diagnosis was confirmed by means of CT scan and the nidus was excised surgically through en bloc resection. The definitive diagnosis was given by means of histopathological examination. Over long-term follow-up, both cases remained asymptomatic and complete bone remodeling at the surgical site was observed. The authors highlight the typical characteristics of the tumor, the unusual location, the differential diagnosis and the treatment.

  2. Rough Design of a Double-Stator Axial Flux Permanent Magnet Generator for a Rim-Driven Marine Current Turbine

    OpenAIRE

    Djebarri, Sofiane; Frédéric Charpentier, Jean; SCUILLER, Franck; Benbouzid, Mohamed; Guemard, Sylvain

    2012-01-01

    This paper deals with the rough design of a Double-Stator Axial Flux Permanent Magnet Machine (DSAFPM) for a rim-driven Marine Current Turbine (MCT). The DSAFPM machine will be compared to a previously developed and realized Radial Flux Permanent Magnet Machine (RFPM); given the same rim-driven MCT specifications. For that purpose, a first-order electromagnetic design model and a thermal one are developed and used to compare active part mass, cost, and thermal behavior of the two machines. Th...

  3. Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

    OpenAIRE

    Lu, Jun; Machius, Mischa; Dulubova, Irina; Dai, Han; Südhof, Thomas C.; Diana R Tomchick; Rizo, Josep

    2006-01-01

    C 2 domains are well characterized as Ca 2+/phospholipid-binding modules, but little is known about how they mediate protein–protein interactions. In neurons, a Munc13–1 C 2A-domain/RIM zinc-finger domain (ZF) heterodimer couples synaptic vesicle priming to presynaptic plasticity. We now show that the Munc13–1 C 2A domain homodimerizes, and that homodimerization competes with Munc13–1/RIM heterodimerization. X-ray diffraction studies guided by nuclear magnetic ...

  4. A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease

    Directory of Open Access Journals (Sweden)

    Webb Glenn F

    2010-04-01

    Full Text Available Abstract Background Multiple myeloma is a hematologic malignancy associated with the development of a destructive osteolytic bone disease. Results Mathematical models are developed for normal bone remodeling and for the dysregulated bone remodeling that occurs in myeloma bone disease. The models examine the critical signaling between osteoclasts (bone resorption and osteoblasts (bone formation. The interactions of osteoclasts and osteoblasts are modeled as a system of differential equations for these cell populations, which exhibit stable oscillations in the normal case and unstable oscillations in the myeloma case. In the case of untreated myeloma, osteoclasts increase and osteoblasts decrease, with net bone loss as the tumor grows. The therapeutic effects of targeting both myeloma cells and cells of the bone marrow microenvironment on these dynamics are examined. Conclusions The current model accurately reflects myeloma bone disease and illustrates how treatment approaches may be investigated using such computational approaches. Reviewers This article was reviewed by Ariosto Silva and Mark P. Little.

  5. Fibrosarcoma of bone

    International Nuclear Information System (INIS)

    A general clinical-radiological description of fibrosarcoma of bone, including tumours with features of malignant fibrous histiocytoma is presented. 104 patients with fibrosarcoma of the long bones are analysed in terms of age and sex distribution, symptoms, duration of symptoms and tumour localization. The radiological findings obtained in patients with fibrosarcoma of the long bones are discussed. The treatment and course of fibrosarcoma of the long bones are discussed. Data on the type of therapy given were available on 103 patients: 67 were treated by ablative surgery either immediately or within three months of preceding local surgery and/or radiotherapy. In the remaining 36 cases treatment consisted of local surgery, radiotherapy or a combination of these, or non-curative (palliative) treatment. In a few cases ablative surgery was performed at a later stage. 13 patients with fibrosarcoma of the axial skeleton and 14 with fibrosarcoma of the jaws are considered. A causistic discussion of patients with a secondary fibrosarcoma is presented. Secondary fibrosarcoma was found in a total of 19 patients (14%); 4 after irradiation. The features of significance for the course of the disease are discussed: general features such as age and sex, tumour localization in the long bones, presence or absence of a pathological fracture, and the radiological and histological characteristics of the tumour. The type of therapy and the occurrence of lung metastases in relation to the course of the disease is also discussed. (Auth.)

  6. Inca bones at asterion

    Directory of Open Access Journals (Sweden)

    Prashant E Natekar

    2014-01-01

    Full Text Available Background: Surgical approach towards asterion has to be done with caution as many surgeons are unfamiliar with the anatomical variations. The asterion corresponds to the site of the posterolateral (mastoid fontanelle of the neonatal skull which closes at the end of the first year. Inca bones provide information as markers for various diseases, and can mislead in the diagnosis of fractures. Observation and Results: 150 dry skull bones from the Department of Anatomy at Goa Medical College, India and other neighboring medical colleges by examining the asterion, and its sutural articulations with parietal, temporal and occipital bones and also anatomical variations if any in adults. Discussion: The anatomical landmarks selected must be reliable and above all easy to identify. Bony structures are more suitable than soft tissue or cartilaginous landmarks because of their rigid and reliable location. Presence of these bones provides false impressions of fractures or the fractures may be interpreted for inca bones especially in the region of asterion either radiologically or clinically which may lead to complications during burr hole surgeries.

  7. Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers

    Directory of Open Access Journals (Sweden)

    Zeeshan Sheikh

    2015-04-01

    Full Text Available Trauma and disease frequently result in fractures or critical sized bone defects and their management at times necessitates bone grafting. The process of bone healing or regeneration involves intricate network of molecules including bone morphogenetic proteins (BMPs. BMPs belong to a larger superfamily of proteins and are very promising and intensively studied for in the enhancement of bone healing. More than 20 types of BMPs have been identified but only a subset of BMPs can induce de novo bone formation. Many research groups have shown that BMPs can induce differentiation of mesenchymal stem cells and stem cells into osteogenic cells which are capable of producing bone. This review introduces BMPs and discusses current advances in preclinical and clinical application of utilizing various biomaterial carriers for local delivery of BMPs to enhance bone regeneration.

  8. Bone Targeted Therapies for Bone Metastasis in Breast Cancer

    OpenAIRE

    Wajeeha Razaq

    2013-01-01

    Cancer metastasis to the bone develops commonly in patients with various malignancies, and is a major cause of morbidity and diminished quality of life in many affected patients. Emerging treatments for metastatic bone disease have arisen from advances in our understanding of the unique cellular and molecular mechanisms that contribute to the bone metastasis. The tendency of cancer cells to metastasize to bone is probably the end result of many factors including vascular pathways, the highly ...

  9. Ectopic bone induction by equine bone protein extract

    DEFF Research Database (Denmark)

    Li, Haisheng; Springer, Marco; Zou, Xuenong; Briest, Arne; Bünger, Cody

    2006-01-01

    Demineralized bone matrix from horse has been reported to be osteoinductive. However, its performance was inferior to autogenous bone graft in terms of new bone formation. In the present experiment, an equine bone protein extract-COLLOSS E was investigated for its osteoinductivity in a rat model. At the mean time, carboxymethyl-cellulose (CMC) was tested as a potential carrier for the protein extract. 18 male Wistar rats (8 weeks) were employed in the experiment. Each rat was implanted randomly ...

  10. Zoledronate reduces unwanted bone resorption in intercalary bone allografts

    OpenAIRE

    Seo, Sung W.; Cho, Samuel K; Storer, Steven K.; Lee, Francis Y

    2009-01-01

    Bone allografts are often hampered by graft incorporation and poor host bone formation. Bisphosphonates, synthetic pyrophosphate analogs, have shown promise in inhibiting bone resorption in human and animal trials. Some in vitro studies have suggested that high dose bisphosphonate may also inhibit bone formation, leading to our hypothesis that an ideal dose of bisphosphonate in allografts could protect allografts from resorption. We transplanted intercalary allografts in to the segmental defe...

  11. Heat sources for bright-rimmed molecular clouds: CO observations of NGC 7822

    International Nuclear Information System (INIS)

    Observations of the 2.6 mm carbon monoxide line in the bright rim NGC 7822 reveal that the peak excitation and column density of the molecule lie in a ridge ahead of the ionization front. Several possibilities for the excitation of this ridge are discussed. Cosmic rays are shown to provide an excellent heat source for Bok globules, but they can account for only approx.20% of the required heating in NGC 7822. Direct shock or compressional heating of the gas could be adequate only if the pressure inside the cloud is much larger than the thermal pressure. If, in fact, this internal pressure is determined by the source of line broadening (e.g., magnetic fields or turbulence), then shock or compressional heating could be important, and pressure equilibrium may exist between the neutral cloud and the bright rim. Heating by warm grains or by the photoelectric effect is also considered, but such mechanisms are probably not important if the only source of radiation is external to the cloud. This is primarily a result of the low cloud density (approx.103 cm-3) inferred from our observations. The extent to which unknown embedded stars may provide the required gaseous heating cannot be estimated from our observations of NGC 7822.An interesting and new heat source is suggested which may have important applications to bright-rimmed clouds or to any other predominantly neutral clouds that may have undergone some recent compression. We suggest that the heat input to neutral gas due to the relaxation of internal magnetic fields will be greatly enhanced during cloud compression (with or without a shock). We show that the power input to the gas will increase more with increasing density than will the cooling rate. As a result, cloud compression can lead to an increase in the gas temperature for a period lasting several million years, which is the decay time of the compressed field. The observed ridge in NGC 7822 may be due to stimulated release of internal magnetic energy

  12. TRIGGERED STAR FORMATION AND YOUNG STELLAR POPULATION IN BRIGHT-RIMMED CLOUD SFO 38

    International Nuclear Information System (INIS)

    We have investigated the young stellar population in and around SFO 38, one of the massive globules located in the northern part of the Galactic H II region IC 1396, using the Spitzer IRAC and MIPS observations (3.6-24 ?m), and followed up with ground-based optical photometric and spectroscopic observations. Based on the IRAC and MIPS colors and H? emission, we identify ?45 young stellar objects (Classes 0/I/II) and 13 probable pre-main-sequence candidates. We derive the spectral types (mostly K- and M-type stars), effective temperatures, and individual extinction of the relatively bright and optically visible Class II objects. Most of the Class II objects show variable H? emission as well as optical and near-infrared photometric variability, which confirm their 'youth'. Based on optical photometry and theoretical isochrones, we estimate the spread in stellar ages to be between 1 and 8 Myr with a median age of 3 Myr and a mass distribution of 0.3-2.2 Msun with a median value around 0.5 Msun. Using the width of the H? emission line measured at 10% peak intensity, we derive the mass accretion rates of individual objects to be between 10-10 and 10-8 Msun yr-1. From the continuum-subtracted H? line image, we find that the H? emission of the globule is not spatially symmetric with respect to the O-type ionizing star HD 206267, and the interstellar extinction toward the globule is also anomalous. We clearly detect an enhanced concentration of YSOs closer to the southern rim of SFO 38 and identify an evolutionary sequence of YSOs from the rim to the dense core of the cloud, with most of the Class II objects located at the bright rim. The YSOs appear to be aligned along two different directions toward the O6.5V type star HD 206267 and the B0V type star HD 206773. This is consistent with the Radiation Driven Implosion (RDI) model for triggered star formation. Further, the apparent speed of sequential star formation is consistent with the speed of propagation of shocks in dense globules as derived from numerical simulations of RDI.

  13. Evaluation of tsunami potential based on conditional probability for specific zones of the Pacific tsunamigenic rim

    Science.gov (United States)

    Koravos, George Ch.; Yadav, R. B. S.; Tsapanos, Theodoros M.

    2015-09-01

    The Pacific tsunamigenic rim is one of the most tsunamigenic regions of the world which has experienced large catastrophic tsunamis in the past, resulting in huge loss of lives and properties. In this study, probabilities of occurrences of large tsunamis with tsunami intensity (Soloviev-Imamura intensity scale) I ? 1.5, I ? 2.0, I ? 2.5, I ? 3.0, I ? 3.5 and I ? 4.0 have been calculated over the next 100 years in ten main tsunamigenic zones of the Pacific rim area using a homogeneous and complete tsunami catalogue covering the time periods from 684 to 2011. In order to evaluate tsunami potential, we applied the conditional probability method in each zone by considering the inter-occurrence times between the successive tsunamis generated in the past that follow the lognormal distribution. Thus, we assessed the probability of the next generation of large tsunamis in each zone by considering the time of the last tsunami occurrence. The a-posteriori occurrence of the last large tsunami has been also assessed, assuming that the time of the last occurrence coincides with the time of the event prior to the last one. The estimated a-posteriori probabilities exhibit satisfactory results in most of the zones, revealing a promising technique and confirming the reliability of the tsunami data used. Furthermore, the tsunami potential in different tsunamigenic zones is also expressed in terms of spatial maps of conditional probabilities for two levels of tsunami intensities I ? 1.5 and I ? 2.5 during next 10, 20, 50 and 100 years. Estimated results reveal that the conditional probabilities in the South America and Alaska-Aleutian zones for larger tsunami intensity I ? 2.5 are in the range of 92-93%, much larger than the Japan (69%), for a time period of 100 years, suggesting that those are the most vulnerable tsunamigenic zones. The spatial maps provide brief atlas of tsunami potential in the Pacific rim area.

  14. Vitamin D, Calcium, and Bone Health

    Science.gov (United States)

    ... Balance › Vitamin D, Calcium, and Bone Health Share: Vitamin D, Calcium, and Bone Health March 2012 Download ... also helps keep your bones strong. Why are vitamin D and calcium important to bone health? Vitamin ...

  15. Bone Density Testing (Beyond the Basics)

    Science.gov (United States)

    ... synonyms Find exact match Print WHAT DOES BONE DENSITY TESTING DO AND WHY IS IT IMPORTANT? People ... they break a bone unexpectedly. That's where bone density tests come in. Bone density tests measure how ...

  16. Bone disease after transplantation: osteoporosis and fractures risk / Doença óssea pós-transplante: risco de osteoporose e fraturas

    Scientific Electronic Library Online (English)

    Carolina A. M., Kulak; Victoria Z. C., Borba; Jaime, Kulak Júnior; Melani Ribeiro, Custódio.

    2014-07-01

    Full Text Available Transplantes de órgão é terapia padrão-ouro para várias doenças em estágio terminal. Perda óssea é uma complicação comum que ocorre em pacientes transplantados. Osteoporose e fraturas por fragilidade são complicações sérias, principalmente no primeiro ano pós-transplante. Muitos fatores podem contri [...] buir para patogênese da doença óssea nesses pacientes. Esta revisão aborda os mecanismos de perda óssea incluindo o papel dos agentes imunossupressores, bem como os fatores específicos da perda óssea após rim, pulmão, fígado, coração e transplante de medula óssea. A prevenção e o tratamento da perda óssea nos pacientes transplantados devem ser realizados para evitar fraturas. Abstract in english Organ transplantation is the gold standard therapy for several end-stage diseases. Bone loss is a common complication that occurs in transplant recipients. Osteoporosis and fragility fractures are serious complication, mainly in the first year post transplantation. Many factors contribute to the pat [...] hogenesis of bone disease following organ transplantation. This review address the mechanisms of bone loss including the contribution of the immunosuppressive agents as well as the specific features to bone loss after kidney, lung, liver, cardiac and bone marrow transplantation. Prevention and management of bone loss in the transplant recipient should be included in their post transplant follow-up in order to prevent fractures.

  17. Radiotherapy for bone metastases

    International Nuclear Information System (INIS)

    Between December 1986 and January 1978, 68 patients with bone metastases were analyzed to evaluate the effect of radiation for the relief of pain. The 68 patients, who had a total of 97 lesions, complained of pain caused by their bone metastasis. The good, fair, and poor responses were found to be 18%, 60%, and 22%, respectively. With reference to the primary neoplasms, the effective response rate was 73% in lung cancer, 100% in breast cancer, 75% in gastric cancer, 100% in hepatic cancer, 100% in bladder cancer, 25% in epipharyngeal cancer, and 70% in the other neoplasms. Depending on the cell types of the lung cancer, the effective response rate was 80% for small cell carcinomas, 72% for adenocarcinomas and 40% for squamous cell carcinomas. Our results suggest that radiotherapy for bone metastases is to be recommended, since the effective response rate was 78% for the relief of pain. (author)

  18. Diabetes and bone health.

    Science.gov (United States)

    Antonopoulou, Marianna; Bahtiyar, Gül; Banerji, Mary Ann; Sacerdote, Alan S

    2013-11-01

    The increasing prevalence of diabetes especially type 2 diabetes worldwide is indisputable. Diabetics suffer increased morbidity and mortality, compared to their non-diabetic counterparts, not only because of vascular complications, but also because of an increased fracture incidence. Both types 1 and 2 diabetes and some medications used to treat it are associated with osteoporotic fractures. The responsible mechanisms remain incompletely elucidated. In this review, we evaluate the role of glycemic control in bone health, and the effect of anti-diabetic medications such as thiazolidinediones, sulfonylureas, DPP-4 inhibitors, and GLP-1 agonists. In addition, we examine the possible role of insulin and metformin as anabolic agents for bone. Lastly, we identify the current and future screening tools that help evaluate bone health in diabetics and their limitations. In this way we can offer individualized treatment, to the at-risk diabetic population. PMID:23628280

  19. Building healthy bones.

    Science.gov (United States)

    Silverwood, Brian

    2003-06-01

    Environmental factors have an important role in deciding whether the skeleton will achieve the genetically determined peak bone mass. Children's lifestyles have changed over the years; with an increasing trend towards computer and television-related non-physical activities and a greater reliance on convenience foods. Childhood and adolescence are critical periods for building healthy, strong bones, therefore the children's nurse should consider the following advice when discussing bone-related conditions with parents of children of all ages: sufficient Vitamin D intake during infancy, childhood and adolescence, sufficient consumption of milk, cheese and yoghurt products, regular physical, weight-bearing activity, maintenance of a healthy body weight, avoidance of smoking during adolescence and adulthood. PMID:12830703

  20. Bone fragility: current reviews and clinical features

    OpenAIRE

    Tranquilli Leali, Paolo; Doria, Carlo; Zachos, Alexandros; Ruggiu, Adriano; Milia, Fabio; Barca, Francesca

    2009-01-01

    Bone strength is determined by a number of important factors, including bone mass and bone shape. A reduction in bone strength is clearly related to fracture. Bone fragility results from a reduction in bone mass and density. If there is a reduction in the connectivity of bone and impact from a mechanical load occurs, bone will fracture. Rather than considering bone fragility as being the result of a reduced amount of bone, we recognize that bone fragility is the result of changes in the mater...

  1. Detecting microdamage in bone.

    Science.gov (United States)

    Lee, T C; Mohsin, S; Taylor, D; Parkesh, R; Gunnlaugsson, T; O'Brien, F J; Giehl, M; Gowin, W

    2003-08-01

    Fatigue-induced microdamage in bone contributes to stress and fragility fractures and acts as a stimulus for bone remodelling. Detecting such microdamage is difficult as pre-existing microdamage sustained in vivo must be differentiated from artefactual damage incurred during specimen preparation. This was addressed by bulk staining specimens in alcohol-soluble basic fuchsin dye, but cutting and grinding them in an aqueous medium. Nonetheless, some artefactual cracks are partially stained and careful observation under transmitted light, or epifluorescence microscopy, is required. Fuchsin lodges in cracks, but is not site-specific. Cracks are discontinuities in the calcium-rich bone matrix and chelating agents, which bind calcium, can selectively label them. Oxytetracycline, alizarin complexone, calcein, calcein blue and xylenol orange all selectively bind microcracks and, as they fluoresce at different wavelengths and colours, can be used in sequence to label microcrack growth. New agents that only fluoresce when involved in a chelate are currently being developed--fluorescent photoinduced electron transfer (PET) sensors. Such agents enable microdamage to be quantified and crack growth to be measured and are useful histological tools in providing data for modelling the material behaviour of bone. However, a non-invasive method is needed to measure microdamage in patients. Micro-CT is being studied and initial work with iodine dyes linked to a chelating group has shown some promise. In the long term, it is hoped that repeated measurements can be made at critical sites and microdamage accumulation monitored. Quantification of microdamage, together with bone mass measurements, will help in predicting and preventing bone fracture failure in patients with osteoporosis. PMID:12924817

  2. Understanding the Structure of Bones

    Science.gov (United States)

    ... structure of bone is very similar to reinforced concrete that is used to make a building or ... yield bones that bend, but do not necessarily break. These diseases are usually diagnosed as "rickets" and ...

  3. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... test that helps physicians diagnose and treat medical conditions. Imaging with x-rays involves exposing a part ... bone growths and bony changes seen in metabolic conditions. assist in the detection and diagnosis of bone ...

  4. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... changes seen in metabolic conditions. assist in the detection and diagnosis of bone cancer . locate foreign objects ... top of page What are the benefits vs. risks? Benefits Bone x-rays are the fastest and ...

  5. Vitamin A and Bone Health

    Science.gov (United States)

    ... supported by your browser. Home Bone Basics Nutrition Vitamin A and Bone Health Publication available in: PDF (100 KB) Related Resources Calcium and Vitamin D El calcio y la vitamina D (Calcium ...

  6. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... of medical imaging. A bone x-ray makes images of any bone in the body, including the ... clothing that might interfere with the x-ray images. Women should always inform their physician and x- ...

  7. Children's Bone Health and Calcium

    Science.gov (United States)

    ... children to stand up straight, walk, run, and lead an active life. Calcium is one of the key dietary building blocks to develop strong bones. Because bone growth is rapid during the adolescent ...

  8. Calcium Intake and Bone health

    Medline Plus

    Full Text Available ... that looked at whether extra calcium improved bone mineral density or helped prevent fractures in women and ... taking supplements only produces small increases in bone mineral density…which the authors wrote are unlikely to ...

  9. Exercise for Your Bone Health

    Science.gov (United States)

    ... supported by your browser. Home Bone Basics Lifestyle Exercise for Your Bone Health Publication available in: PDF ( ... ???? ) Related Resources Alcoholism Bed Rest and Immobilization Exercise and Osteogenesis Imperfecta Overtraining Risks for Women Oral ...

  10. Calcium Intake and Bone health

    Medline Plus

    Full Text Available ... looked at whether extra calcium improved bone mineral density or helped prevent fractures in women and men ... supplements only produces small increases in bone mineral density…which the authors wrote are unlikely to lead ...

  11. Meniere's disease, petrous bone tomography

    International Nuclear Information System (INIS)

    Direct measurements on tomograms of the petrous bone in Meniere's disease revealed a decreased thickness of the retrolabyrinthine part of the petrous bone. This could help to confirm previous theories that the cause of Meniere's disease is developmental. (orig.)

  12. Oral Health and Bone Disease

    Science.gov (United States)

    ... supported by your browser. Home Bone Basics Lifestyle Oral Health and Bone Disease Publication available in: PDF ( ... Imperfecta Overtraining Risks for Women Smoking Partner Resources Oral Health FAQs (OWH) Periodontal (Gum) Disease (NIDCR) Seal ...

  13. Bone Anchored Hearing Treatment Procedure

    Medline Plus

    Full Text Available ... using bone conduction. The Baha device uses sound vibrations, and those vibrations then are passed from the side with no ... from a normal soundwave into a bone conduction vibration, and that is what is passed then through ...

  14. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... little information about muscles, tendons or joints. An MRI may be more useful in identifying bone and ... bones and the spinal cord can be evaluated). MRI can also detect subtle or occult fractures or ...

  15. Spinal bone graft - series (image)

    Science.gov (United States)

    ... is made over the bone defect, and the bone graft is shaped around and inserted into the defect. The graft is held in place with pins, plates, or screws. The incisions are stitched (sutured) closed. A splint ...

  16. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... shin), ankle or foot. top of page What are some common uses of the procedure? A bone ... or changed over time. top of page What are the benefits vs. risks? Benefits Bone x-rays ...

  17. Calcium Intake and Bone health

    Medline Plus

    Full Text Available ... Videos & Tools You Are Here: Home ? Latest Health News ? Calcium Intake and Bone health URL of this page: https://www.nlm.nih.gov/medlineplus/videos/news/Calcium_Intake_100115.html Calcium Intake and Bone ...

  18. Bone - marrow postirradiation syndrome

    International Nuclear Information System (INIS)

    Quantitative and qualitative changes in haemopoietic cells in chicken bone Marrow were investigated after acute single irradiation with doses 4.5 Gy and 5 Gy. Samples of bone marrow were obtained from proximal femoral epiphysis of decapitated chickens. Marrow smears were prepared and stained according to Pappenheim. Qualitative examination of myelogram showed proliferation of adipose tissue, hypocellularity, caryolyosis, caryorexis, disintegration of cells and proliferation of cells which could not be differentiated. Quantitative examination revealed high radiosensitivity of blast cells and lymphocytes shortly after irradiation. (authors)

  19. Nasal bone fracture.

    OpenAIRE

    A. J. Ashoor; F. A. Alkhars

    2000-01-01

    OBJECTIVES To study fracture nasal bone at King Faisal Hospital University in Al-Khobar from various aspects, to present our experience and to compare the result with previous works. METHODS A prospective study conducted from January 1997 to May 1998 including all new cases of fracture nasal bone presented at our emergency department. Plain x-ray of the nose is requested for all patients except one in whom pregnancy is suspected. Reduction of fracture nose was carried out 2-7 days po...

  20. Scanning of bone metastases

    International Nuclear Information System (INIS)

    The Centers against cancer of Caen, Angers, Montpellier, Strasbourg and 'the Curie Foundation' have confronted their experience in detection of bone metastases by total body scanning. From the investigation by this procedure, of 1,467 patients with cancer, it results: the confrontation between radio and scanning shows a rate of false positive and false negative identical to the literature ones; the countage scanning allows to reduce the number of false positive; scanning allows to direct bone biopsy and to improve efficiency of histological examination

  1. Descemet membrane endothelial keratoplasty with a stromal rim in the treatment of posterior polymorphous corneal dystrophy

    Directory of Open Access Journals (Sweden)

    Pavel Studeny

    2012-01-01

    Full Text Available A 20-year-old patient, diagnosed with posterior polymorphous corneal dystrophy, developed corneal edema for which he underwent Descemet membrane endothelial keratoplasty with a stromal rim (DMEK-S in the right eye. No intra- or postoperative complications were noted. At the last follow-up 2 years and 9 months after the procedure, the best corrected visual acuity was 1.0 and endothelial cell density declined from 3533 cells/mm 2 to 1012 cells/mm 2 . Despite the endothelial cell loss, DMEK-S appears to be a good alternative to other surgical techniques for the treatment of corneal endotheliopathies, and it may be of benefit to young patients.

  2. High-R Walls for New Construction Structural Performance: Integrated Rim Header Testing

    Energy Technology Data Exchange (ETDEWEB)

    DeRenzis, A. [NAHB Research Center, Upper Marlboro, MD (United States); Kochkin, V. [NAHB Research Center, Upper Marlboro, MD (United States); Wiehagen, J. [NAHB Research Center, Upper Marlboro, MD (United States)

    2013-01-01

    Two prominent approaches within the Building America Program to construct higher R-value walls have included use of larger dimension framing and exterior rigid foam insulation. These approaches have been met with some success; however for many production builders, where the cost of changing framing systems is expensive, the changes have been slow to be realized. In addition, recent building code changes have raised some performance issues for exterior sheathing and raised heel trusses, for example, that indicates a need for continued performance testing for wall systems. The testing methods presented in this report evaluate structural rim header designs over openings up to 6 ft wide and applicable to one- and two-story homes.

  3. Comparative analysis of environmental carrying capacity of the Bohai Sea Rim area in China.

    Science.gov (United States)

    Lin, Lu; Liu, Yi; Chen, Jining; Zhang, Tianzhu; Zeng, Siyu

    2011-11-01

    Environmental carrying capacity is an essential metric for measuring regional sustainability. Although the term "carrying capacity" has been applied for over a century, the concept definition, quantitative methods and comprehensive evaluation remain arguable. This study analyzed the carrying capacity of four environmental elements, including water resources, air, surface water and offshore sea, and integrated them into a comprehensive index to represent overall regional profiles of resources and environment. The method was then applied to thirteen municipalities in the Bohai Sea Rim area, one of the most rapidly developing regions in transition China. The results show that the comprehensive environmental carrying capacity of the municipalities in the south sub-region were largest in 2007, while that of the west municipalities were lowest. The regional economic development exceeded the overall environmental carrying capacity by 36% and the west sub-region area deserves overwhelming attention for future industrial allocation. PMID:22009177

  4. Distal myopathies a review: Highlights on distal myopathies with rimmed vacuoles

    Directory of Open Access Journals (Sweden)

    Malicdan May Christine

    2008-01-01

    Full Text Available Distal myopathies are a group of heterogeneous disorders classified into one broad category due to the presentation of weakness involving the distal skeletal muscles. The recent years have witnessed increasing efforts to identify the causative genes for distal myopathies. The identification of few causative genes made the broad classification of these diseases under "distal myopathies" disputable and added some enigma to why distal muscles are preferentially affected. Nevertheless, with the clarification of the molecular basis of specific conditions, additional clues have been uncovered to understand the mechanism of each condition. This review will give a synopsis of the common distal myopathies, presenting salient facts regarding the clinical, pathological, and molecular aspects of each disease. Distal myopathy with rimmed vacuoles, or Nonaka myopathy, will be discussed in more detail.

  5. Origin and nature of intercrater plains in northwestern rim of Hellas Basin

    Science.gov (United States)

    Salese, F.; Mangold, N.; Ansan, V.; Carter, J.; Ody, A.; Poulet, F.; Ori, G. G.

    2015-10-01

    The nature and origin of intercrater plains within the martian cratered highlands is a major unresolved and controversial issue that have been somewhat enigmatic, receiving little attention since the Mariner era [1,2,3,4,5]. Are flat-lying smooth plains sedimentary or volcanic or both ? Whether these plains are mainly constituted of volcanic material or sediments is a crucial difference for understanding the surface environment of the Noachian period. In order to answer to previous question, we focus our study on the NW rim of Hellas basin defining first the relative stratigraphy and absolute age, throughout crater counting method,of the different units by a precise mapping and correlating then these units with mineralogy and texture.

  6. Numerical Simulation of Stresses in Thin-rimmed Spur Gears with Keyway

    Directory of Open Access Journals (Sweden)

    B. Br?žek

    2003-01-01

    Full Text Available This paper contains an investigation of the key on a stress distribution in a thin-rimmed spur gear. A stress analysis was carried out by means of the Finite Element Method (FEM. The 2D-FE analysis has helped to find the influence of turning the gearing towards the keyway on the stress in the loaded root of the tooth and in the keyway. 2D and 3D numerical analysis has been used to find mutual influence of every single notch (root of tooth and keyway, influence of thickness of the hub, length of the key and the form of loading. Verification has been carried out through experimental method.

  7. [Anesthetic Management of Laparoscopic Nephrectomy for a Renal Cancer Patient with Distal Myopathy of Rimmed Vacuole].

    Science.gov (United States)

    Saito, Junichi; Noguchi, Satoko; Matsumoto, Anna; Jinushi, Kei; Kasai, Toshinori; Kitayama, Masato; Hirota, Kazuyoshi

    2015-02-01

    A 56-year-old male with distal myopathy of rimmed vacuoles underwent laparoscopic nephrectomy. Anesthesia was induced with propofol, remifentanil and ketamine. Tracheal intubation using McGRATH was uneventful without using muscle relaxants. Then ultrasound-guided right thoracic paravertebral (TPVB) block was performed using 20 ml 0.75% ropivacaine with 10 ml 2% lidocaine by 3 injections of 10 ml each at T9 to T11. General anesthesia was maintained with propofol, remifentanil and ketamine monitoring bispectral index. Good surgical condition and pneumoperitoneum were maintained without using muscle relaxants. His postoperative course was smooth and uneventful, even though a small amount of fentanyl was administrated to relieve wound pain. This case suggests that McGRATH and ultrasound-guided TPVB can be one of the options to avoid using muscle relaxants in patient with neuromuscular disease. PMID:26121810

  8. Development of RIMS apparatus for isotope analysis of calcium in nuclear waste materials

    International Nuclear Information System (INIS)

    We have developed a frequency stabilized laser system of RIMS analysis of a long-lived radionuclide of calcium (41Ca) in concrete waste materials. A stable reference laser has been developed using magnetically induced circular dichroism of atomic rubidium. The frequency stability was estimated to be 50 kHz over 8-h period from beat frequency measurement. Furthermore, a computer-controlled fringe offset lock system has been developed to transfer the high frequency stability to the other lasers for three-step excitation of atomic calcium. By using the system precise frequency tuning of 1 MHz error over 1 GHz scan was realized. The overall frequency tuning precision was also confirmed by a multistep fluorescence and resonance ionization spectroscopy of calcium. (author)

  9. Growth and instability of the liquid rim in the crown splash regime

    CERN Document Server

    Agbaglah, G

    2014-01-01

    We study the formation, growth, and disintegration of jets following impact of a drop on a thin film of the same liquid for We < 1000 and Re < 2000 using a combination of numerical simulations and linear stability theory (Agbaglah et al. 2013). Our simulations faithfully capture this phenomena and are in good agreement with experimental profiles obtained from high-speed X-ray imaging.We obtain scaling relations from our simulations and use these as inputs to our stability analysis. The resulting prediction for the most unstable wavelength are in excellent agreement with experimental data. Our calculations show that the dominant destabilizing mechanism is a competition between capillarity and inertia but that deceleration of the rim provides an additional boost to growth. We also predict over the entire parameter range of our study the number and timescale for formation of secondary droplets formed during a splash, based on the assumption that the most unstable mode sets the droplet number.

  10. Female Reproductive System and Bone

    OpenAIRE

    Clarke, Bart L.; Khosla, Sundeep

    2010-01-01

    The female reproductive system plays a major role in regulating the acquisition and loss of bone by the skeleton from menarche through senescence. Onset of gonadal sex steroid secretion at puberty is the major factor responsible for skeletal longitudinal and radial growth, as well as significant gain in bone density, until peak bone density is achieved in third decade of life. Gonadal sex steroids then help maintain peak bone density until menopause, including during the transient changes in ...

  11. Vertebral bone loss in menopause.

    OpenAIRE

    ISAIA, Giovanni Carlo

    1990-01-01

    A direct correlation between loss of ovarian function and reduction of bone mass is well established. The incidence of fractures sharply increases with age starting from the menopause. Therefore, it is very important to know the rate of bone loss occurring after menopause, at both trabecular and cortical levels. Several factors may contribute to the reduction of bone mass in menopause. Reduced estrogen secretion results in reduced intestinal calcium absorption, increased bone resorption, and ...

  12. Cancellous structure of tarsal bones.

    OpenAIRE

    Sinha, D N

    1985-01-01

    The internal structure of the tarsal bones has been studied to investigate their cancellous architecture. It is revealed that these bones have fine and coarse meshworks and even a tendency for obliteration of the trabecular pattern in the bones lying distal to this midtarsal joint. Internal structure of the talus does not show an arched pattern of bony lamellae. An increased density of bony lamellae in the internal structure of the navicular bone could result from excessive stress, enforced b...

  13. Bone health in cancer patients

    DEFF Research Database (Denmark)

    Coleman, R; Body, J J; Aapro, M; Hadji, P; Herrstedt, J

    2014-01-01

    There are three distinct areas of cancer management that make bone health in cancer patients of increasing clinical importance. First, bone metastases are common in many solid tumours, notably those arising from the breast, prostate and lung, as well as multiple myeloma, and may cause major morbidity including fractures, severe pain, nerve compression and hypercalcaemia. Through optimum multidisciplinary management of patients with bone metastases, including the use of bone-targeted treatments s...

  14. Transcutaneous Raman Spectroscopy of Bone

    Science.gov (United States)

    Maher, Jason R.

    Clinical diagnoses of bone health and fracture risk typically rely upon measurements of bone density or structure, but the strength of a bone is also dependent upon its chemical composition. One technology that has been used extensively in ex vivo, exposed-bone studies to measure the chemical composition of bone is Raman spectroscopy. This spectroscopic technique provides chemical information about a sample by probing its molecular vibrations. In the case of bone tissue, Raman spectra provide chemical information about both the inorganic mineral and organic matrix components, which each contribute to bone strength. To explore the relationship between bone strength and chemical composition, our laboratory has contributed to ex vivo, exposed-bone animal studies of rheumatoid arthritis, glucocorticoid-induced osteoporosis, and prolonged lead exposure. All of these studies suggest that Raman-based predictions of biomechanical strength may be more accurate than those produced by the clinically-used parameter of bone mineral density. The utility of Raman spectroscopy in ex vivo, exposed-bone studies has inspired attempts to perform bone spectroscopy transcutaneously. Although the results are promising, further advancements are necessary to make non-invasive, in vivo measurements of bone that are of sufficient quality to generate accurate predictions of fracture risk. In order to separate the signals from bone and soft tissue that contribute to a transcutaneous measurement, we developed an overconstrained extraction algorithm that is based upon fitting with spectral libraries derived from separately-acquired measurements of the underlying tissue components. This approach allows for accurate spectral unmixing despite the fact that similar chemical components (e.g., type I collagen) are present in both soft tissue and bone and was applied to experimental data in order to transcutaneously detect, to our knowledge for the first time, age- and disease-related spectral differences in murine bone.

  15. Osteonecrosis Mimicking Bone Metastasis in Femoral Head on {sup 18F} FDG PET/CT: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Kyu Ho; Oh, Jin Kyoung; Kim, Sung Hoon; Yoo, Ik Dong; Choi, Eun Kyoung; Han, Eun Ji [The Catholic Univ. of Korea, Seoul (Korea, Republic of)

    2011-03-15

    A 77 year old woman underwent chemotherapy, radiotherapy, and brachytherapy for cervical cancer 9 years ago. On a follow up {sup 18F} fluorodeoxyglucose (FDG) PET/CT image, focal FDG uptake was noted in a focal osteolytic lesion in the right femoral head. During magnetic resonance imaging, this lesion showed subchondral dark signal intensity rim on T1 weighted image and double line sign on T2 weighted image, suggestive of osteonecrosis. The lesion was pathologically confirmed as osteonecrosis after surgery. This case demonstrates that osteonecrosis of the femoral head may demonstrate focal FDG uptake mimicking bone metastasis.

  16. Osteonecrosis Mimicking Bone Metastasis in Femoral Head on 18F FDG PET/CT: A Case Report

    International Nuclear Information System (INIS)

    A 77 year old woman underwent chemotherapy, radiotherapy, and brachytherapy for cervical cancer 9 years ago. On a follow up 18F fluorodeoxyglucose (FDG) PET/CT image, focal FDG uptake was noted in a focal osteolytic lesion in the right femoral head. During magnetic resonance imaging, this lesion showed subchondral dark signal intensity rim on T1 weighted image and double line sign on T2 weighted image, suggestive of osteonecrosis. The lesion was pathologically confirmed as osteonecrosis after surgery. This case demonstrates that osteonecrosis of the femoral head may demonstrate focal FDG uptake mimicking bone metastasis.

  17. Miocene to Present Sea Level and the Origin of Modern Rimmed Atoll Morphology

    Science.gov (United States)

    Toomey, M.; Perron, J. T.; Raymo, M. E.; Ashton, A. D.

    2014-12-01

    Rising sea-level over the next century will reshape our coastlines and make low-lying islands more vulnerable to extreme events. Atolls could potentially provide unique geologic records from periods of high sea level analogous to those we might experience over the coming centuries. However, sea-level records from atolls have been largely overlooked, in part because the processes that shape coral reef and atoll form are often complex and, in many cases, remain unexplored. Darwin's canonical model, which proposes an evolution from fringing reef to barrier reef to atoll as an ocean island ages and subsides, cannot explain the stratigraphy or morphology of many island reefs. We will present a study that combines a numerical model of reef development with existing stratigraphic records from Pacific atolls. The model, driven by sea level, simulates the evolution of atoll morphology using parameterizations of coral growth, rim derived sediment and in situ production, dissolution, and subsidence. We use it to solve for late-Miocene to present sea level by iteratively changing the ice volume and deep-ocean temperature corrections for converting deep-ocean, benthic, ?18O to sea level and finding the best-fit between the model output and corelog stratigraphy from Enewetak Atoll. We then compare lagoon depths produced by the model for different island sizes and dissolution rates (but the same subsidence and sediment production rates) to an independent dataset of real-world observations from the Marshall, Gilbert and Caroline Island chains. Our model results suggest that a period of sustained low sea level occurred during the late Miocene before rising above present moving into the Pliocene. We propose that it was atoll exposure and enhanced lagoon dissolution during the subsequent sea-level fall since the late Pliocene, ~2.7 Ma - not crustal subsidence, as Darwin's canonical model of atoll evolution presumes - that likely drove the development of modern rimmed atoll morphology.

  18. RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays

    Science.gov (United States)

    Stanislaus, Romesh; Carey, Mark; Deus, Helena F; Coombes, Kevin; Hennessy, Bryan T; Mills, Gordon B; Almeida, Jonas S

    2008-01-01

    Background Reverse Phase Protein Arrays (RPPA) are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technologies, substantial amounts of analytical data are generated. Over 1000 samples may be printed on a single nitrocellulose slide. Up to 100 different proteins may be assessed using immunoperoxidase or immunoflorescence techniques in order to determine relative amounts of protein expression in the samples of interest. Results In this report an RPPA Information Management System (RIMS) is described and made available with open source software. In order to implement the proposed system, we propose a metadata format known as reverse phase protein array markup language (RPPAML). RPPAML would enable researchers to describe, document and disseminate RPPA data. The complexity of the data structure needed to describe the results and the graphic tools necessary to visualize them require a software deployment distributed between a client and a server application. This was achieved without sacrificing interoperability between individual deployments through the use of an open source semantic database, S3DB. This data service backbone is available to multiple client side applications that can also access other server side deployments. The RIMS platform was designed to interoperate with other data analysis and data visualization tools such as Cytoscape. Conclusion The proposed RPPAML data format hopes to standardize RPPA data. Standardization of data would result in diverse client applications being able to operate on the same set of data. Additionally, having data in a standard format would enable data dissemination and data analysis. PMID:19102773

  19. RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays

    Directory of Open Access Journals (Sweden)

    Hennessy Bryan T

    2008-12-01

    Full Text Available Abstract Background Reverse Phase Protein Arrays (RPPA are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technologies, substantial amounts of analytical data are generated. Over 1000 samples may be printed on a single nitrocellulose slide. Up to 100 different proteins may be assessed using immunoperoxidase or immunoflorescence techniques in order to determine relative amounts of protein expression in the samples of interest. Results In this report an RPPA Information Management System (RIMS is described and made available with open source software. In order to implement the proposed system, we propose a metadata format known as reverse phase protein array markup language (RPPAML. RPPAML would enable researchers to describe, document and disseminate RPPA data. The complexity of the data structure needed to describe the results and the graphic tools necessary to visualize them require a software deployment distributed between a client and a server application. This was achieved without sacrificing interoperability between individual deployments through the use of an open source semantic database, S3DB. This data service backbone is available to multiple client side applications that can also access other server side deployments. The RIMS platform was designed to interoperate with other data analysis and data visualization tools such as Cytoscape. Conclusion The proposed RPPAML data format hopes to standardize RPPA data. Standardization of data would result in diverse client applications being able to operate on the same set of data. Additionally, having data in a standard format would enable data dissemination and data analysis.

  20. Distal myopathy with rimmed vacuoles: Report on clinical characteristics in 23 cases

    Directory of Open Access Journals (Sweden)

    Nalini A

    2010-01-01

    Full Text Available Background: Distal myopathy with rimmed vacuoles (DMRV is an autosomal recessive (AR myopathy characterized clinically by the preferential involvement of the tibialis anterior and has been reported predominantly in the Japanese population. Materials and Methods: A case series of DMRV patients seen over a period of 3 years at a tertiary national referral center for neurological disorders in south India. Results: We describe the clinical characteristics, muscle magnetic resonance imaging (MRI findings and classical histopathological feature in 23 patients. There were 12 men and 11 women. Mean age of onset was 27.04 ± 6.35 years (10-39 years. Onset was in the second or third decade in a majority. Mean age at presentation was 33.95 ± 6.35 years (25-48 years. Mean duration of illness was 6.74 ± 4.8 years (1-18 years. Consanguinity was reported in eight (34.8% patients. The predominant and initial manifestation was bilateral foot drop in all patients. Muscle MRI demonstrated classical involvement of the anterior compartment muscles of the lower legs and the posterior compartment muscles of the thighs and the quadriceps was normal in all. Muscle histopathology showed numerous fibers containing rimmed vacuoles. Necrotic fibers or phagocytosis or regenerating fibers were rarely noted or were absent. Conclusions: DMRV is a rare AR myopathy. The disorder presents as progressive foot drop and hence has many differential diagnoses. It is easily mistaken as neuropathy of hereditary nature and hence it is extremely important to recognize the preferential muscle involvement and characterize the phenotype. This is the first report from India with patients having characteristic phenotype of Nonaka?s/AR hereditary inclusion body myopathy with quadriceps sparing, and all were confirmed by histopathology.

  1. X-RAY PROPER MOTIONS AND SHOCK SPEEDS ALONG THE NORTHWEST RIM OF SN 1006

    International Nuclear Information System (INIS)

    We report the results of an X-ray proper-motion measurement for the NW rim of SN 1006, carried out by comparing Chandra observations from 2001 to 2012. The NW limb has predominantly thermal X-ray emission, and it is the only location in SN 1006 with significant optical emission: a thin, Balmer-dominated filament. For most of the NW rim, the proper motion is ?0.''30 yr–1, essentially the same as has been measured from the H? filament. Isolated regions of the NW limb are dominated by nonthermal emission, and here the proper motion is much higher, 0.''49 yr–1, close to the value measured in X-rays along the much brighter NE limb, where the X-rays are overwhelmingly nonthermal. At the 2.2 kpc distance to SN 1006, the proper motions imply shock velocities of ?3000 km s–1 and ?5000 km s–1 in the thermal and nonthermal regions, respectively. A lower velocity behind the H? filament is consistent with the picture that SN 1006 is encountering denser gas in the NW, as is also suggested by its overall morphology. In the thermally dominated portion of the X-ray shell, we also see an offset in the radial profiles at different energies; the 0.5-0.6 keV peak dominated by O VII is closer to the shock front than that of the 0.8-3 keV emission—due to the longer times for heavier elements to reach ionization states where they produce strong X-ray emission.

  2. A degradable soybean-based biomaterial used effectively as a bone filler in vivo in a rabbit

    Energy Technology Data Exchange (ETDEWEB)

    Merolli, Antonio [Department of Orthopaedic Surgery, The Catholic University in Rome, Complesso Columbus, via Moscati 31, 00168 Rome (Italy); Nicolais, Luigi; Ambrosio, Luigi [Institute of Composite and Biomedical Materials, Consiglio Nazionale delle Ricerche, Piazzale Tecchio 80, 80130 Napoli (Italy); Santin, Matteo [School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Lewes Road, Brighton BN2 4 GJ (United Kingdom)

    2010-02-15

    The 'gold standard' for bone filling is currently the bone autograft, but its use is limited by material availability and by the possible risks of infection or other donor site morbidity. Materials proposed so far as bone fillers do not show all the characteristics which are desirable. These are (a) osteoconductivity, (b) controlled biodegradation and (c) ease of adaptation to the implantation site. Recently, a new class of biodegradable material based on soybeans has been presented which shows good mechanical properties and an intrinsic bioactivity on inflammatory and tissue cells in vitro. The authors investigated the morphology in vivo of bone response in repairing a surgical lesion in the presence of granules of a novel soybean-based biomaterial (SB), comparing it with a sham-operated contralateral lesion of critical size (non-healing model); 26 operations were performed in New Zealand White rabbits, with back scattered electron microscopy as the analysis technique of choice. Implantation of SB granules over 8 weeks produced bone repair with features distinct from those obtained by healing in a non-treated defect. New and progressively maturing trabeculae appeared in the animal group where SB granules were implanted, while sham operation produced only a rim of pseudo-cortical bone still featuring a large defect. The trabeculae forming in the presence of SB granules had features typical of reticular bone. These findings suggest that the bone regeneration potential of SB granules and their intrinsic bioactivity, combined with their relatively easy and cost-effective preparation procedures, make them suitable candidates as a bone filler in clinical applications.

  3. A degradable soybean-based biomaterial used effectively as a bone filler in vivo in a rabbit

    International Nuclear Information System (INIS)

    The 'gold standard' for bone filling is currently the bone autograft, but its use is limited by material availability and by the possible risks of infection or other donor site morbidity. Materials proposed so far as bone fillers do not show all the characteristics which are desirable. These are (a) osteoconductivity, (b) controlled biodegradation and (c) ease of adaptation to the implantation site. Recently, a new class of biodegradable material based on soybeans has been presented which shows good mechanical properties and an intrinsic bioactivity on inflammatory and tissue cells in vitro. The authors investigated the morphology in vivo of bone response in repairing a surgical lesion in the presence of granules of a novel soybean-based biomaterial (SB), comparing it with a sham-operated contralateral lesion of critical size (non-healing model); 26 operations were performed in New Zealand White rabbits, with back scattered electron microscopy as the analysis technique of choice. Implantation of SB granules over 8 weeks produced bone repair with features distinct from those obtained by healing in a non-treated defect. New and progressively maturing trabeculae appeared in the animal group where SB granules were implanted, while sham operation produced only a rim of pseudo-cortical bone still featuring a large defect. The trabeculae forming in the presence of SB granules had features typical of reticular bone. These findings suggest that the bone regeneration potential of SB granules and their intrinsic bioactivity, combined with their relatively easy and cost-effective preparation procedures, make them suitable candidates as a bone filler in clinical applications.

  4. The Effects of Self-Shadowing by a Puffed up Inner Rim in Scattered Light Images of Protoplanetary Disks

    CERN Document Server

    Dong, Ruobing

    2015-01-01

    We explore whether protoplanetary disks with self-shadowing from puffed up inner rims exhibit observable features in scattered light images. We use both self-consistent hydrostatic equilibrium calculations and parameterized models to produce the vertically puffed up inner rims. We find that, in general, the transition between the shadowed and flared regions occurs in a smooth manner over a broad radius range, and no sudden jump exists at the outer edge of the shadow in either the disk temperature or density structures. As a result, a puffed up rim cannot create sharp ring/arc/spiral-arm-like features in the outer disk as have been detected in recent direct NIR imaging of disks. On the other hand, if the puffed up rim has a sharp edge in the vertical direction, the shadowing effect can produce a distinct 3-stage broken power law in the radial intensity profile of the scattered light, with 2 steep surface brightness radial profiles in the inner and outer disk joined by a shallow transition region around the sha...

  5. Thermodynamic model for diffusion controlled reaction rim growth in a binary system: application to the forsterite-enstatite-quartz system.

    Czech Academy of Sciences Publication Activity Database

    Abart, R.; Pertischeva, E.; Fischer, F. D.; Svoboda, Ji?í

    2009-01-01

    Ro?. 309, ?. 2 (2009), s. 114-131. ISSN 0002-9599 R&D Projects: GA MŠk OC 163 Institutional research plan: CEZ:AV0Z20410507 Keywords : Thermodynamic model * diffusion * rim growth Subject RIV: BJ - Thermodynamics Impact factor: 2.284, year: 2009

  6. The Effects of Self-shadowing by a Puffed-up Inner Rim in Scattered Light Images of Protoplanetary Disks

    Science.gov (United States)

    Dong, Ruobing

    2015-09-01

    We explore whether protoplanetary disks with self-shadowing from puffed-up inner rims exhibit observable features in scattered light images. We use both self-consistent hydrostatic equilibrium calculations and parameterized models to produce the vertically puffed-up inner rims. We find that, in general, the transition between the shadowed and flared regions occurs in a smooth manner over a broad radius range, and no sudden jump exists at the outer edge of the shadow in either the disk temperature or density structures. As a result, a puffed-up rim cannot create sharp ring/arc/spiral-arm-like features in the outer disk as have been detected in recent direct near-infrared imaging of disks. On the other hand, if the puffed-up rim has a sharp edge in the vertical direction, the shadowing effect can produce a distinct three-stage broken power law in the radial intensity profile of the scattered light, with two steep surface brightness radial profiles in the inner and outer disk joined by a shallow transition region around the shadow edge. These types of scattered light profiles may have already been observed, such as in the recent Subaru direct imaging of the TW Hydrae system.

  7. Isotopic distribution from core to rim of a PWR spent nuclear fuel by shielded laser ablation ICP MS

    International Nuclear Information System (INIS)

    Spent nuclear fuel discharged from a pressurized light water reactor contains fission products, U, Pu, and other actinides. Due to a neutron capture by 238U in the rim region and a temperature gradient between the center and the rim of a fuel pellet, a considerable increase in the concentration of fission products, U, Pu, and other actinides are expected at a pellet periphery. Characterization of the local chemical properties with a varying radial gradient is our main concern. For an analysis, a spent nuclear fuel originating from the Yeonggwang 4 PWR reactor with an average burn up of 55,600 MWd/MtU was chosen as a test specimen. The isotopic ratio was measured from core to rim of the spent fuel by a radiation shielded LA ICP MS system. Sampling was performed along the diameter of a sample specimen by reducing the intervals from 500?m to 100?m. It was observed that the isotopic ratios in the center of a sample specimen remain almost constant and increased near the pellet periphery due to the rim effect. In addition, the isotopic distribution measured by the radiation shielded LA ICP MS was compared with that of the calculated value by the Origin2 code

  8. Heterogenous Oxygen Isotopic Composition of a Complex Wark-Lovering Rim and the Margin of a Refractory Inclusion from Leoville

    Science.gov (United States)

    Simon, J. I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.

    2014-01-01

    Wark-Lovering (WL) rims [1] surrounding many refractory inclusions represent marker events in the early evolution of the Solar System in which many inclusions were exposed to changes in pressure [2], temperature [3], and isotopic reservoirs [4-7]. The effects of these events can be complex, not only producing mineralogical variability of WL rims [2], but also leading to mineralogical [8-10] and isotopic [7, 11, 12] changes within inclusion interiors. Extreme oxygen isotopic heterogeneity measured in CAIs has been explained by mixing between distinct oxygen gas reservoirs in the nebula [13]. Some WL rims contain relatively simple mineral layering and/or are isotopically homogeneous [14, 15]. As part of a larger effort to document and understand the modifications observed in some CAIs, an inclusion (L6) with a complex WL rim from Leoville, a member of the reduced CV3 subgroup was studied. Initial study of the textures and mineral chemistry was presented by [16]. Here we present NanoSIMS oxygen isotopic measurements to complement these petrologic observations.

  9. Structural uplift and ejecta thickness of lunar mare craters: New insights into the formation of complex crater rims

    Science.gov (United States)

    Krüger, Tim; Kenkmann, Thomas

    2015-04-01

    Most complex impact craters on solid planetary surfaces throughout the Solar System exhibit elevated crater rims similar to the elevated crater rims of simple craters. In principal the final elevation of the crater rim is due to the deposition of ejecta on the structurally uplifted bedrock of the pre-impact surface. For simple craters the elevated crater rim is due to two well understood factors: (i) Emplacement of the coherent proximal ejecta material at the transient cavity rim (overturned flap) [1]. (ii) Structural uplift of the pre-impact surface in the proximity of the transient cavity [1, 2]. The amount of structural uplift at the rim of simple craters is due to plastic thickening of the target rock, the emplacement of interthrust wedges and/or the injection of dike material in the underlying target [1, 2, 3, 4]. Both factors, (i) and (ii), are believed to equally contribute to the structural uplift of simple craters. Larger craters have complex morphologies and the crater's extent may considerably exceed that of the transient cavity due to gravity-driven adjustment movements. For instance, the Ries crater's final diameter is twice of its transient cavity size. It is expected that both ejecta thickness and structural uplift decrease with increasing distance from the rim of the transient crater. For lunar craters the continuous ejecta extends up to 2 crater radii from the crater center. The ejecta blanket thickness ET at the rim crest of the transient crater (which is inside the final crater) is a function of the distance r from the crater center, with RT as the radius of the transient crater [2, 6, 7] and is expressed by the following function: (1) ET = 0.033 RT (r/RT)^-3.0 for r ? RT [5, 6] The structural uplift is largest at the transient cavity rim and gets rapidly smaller with increasing distance to the crater center and disappears after 1.3 - 1.7 crater radii [1]. These circumstances raise the question, how elevated rims of complex craters form? Based on High-resolution imagery from the Lunar Reconnaissance Orbiter Camera [8] we studied several complex lunar craters and precisely measured their total rim height, the amount of structural uplift and the ejecta thickness along the final crater rim. Our detailed investigation is focused on the lunar mare craters Bessel (16 km), Euler (28 km), Kepler (32 km), Harpalus (39 km) and Bürg (41 km). A mean of 70.6% of the rim height of the final crater of the five lunar craters is due to the structural uplift of the target. The rest is contributed by the ejecta thickness (29.4 %). These results are in good agreement with previous studies [1]. The final crater diameter is given as a multiple of the transient crater diameter (DT) for all investigated craters: Bessel (1.01DT), Euler (1.16DT), Kepler (1.21DT), Harpalus (1.40DT) and Bürg (1.10DT). The transient crater diameter increases with the diameter of the final crater. Currently we are assessing the mechanism of a structural uplift at larger distance to the transient cavity rim. The structural uplift of the crater rim only by dike injection and plastic deformation in the underlying target material seems unlikely at distances >1 km from the transient crater cavity. Other mechanisms, like reverse faulting, beginning in the excavation stage of crater formation, could be responsible for additional structural uplift of the crater rim. Nevertheless, our results show that structural uplift is a more dominant effect than ejecta emplacement for complex impact craters. References: [1] Sharpton V.L. (2014) JGR, 119, 1, 154-168. [2] Melosh H.J. (1989) Oxford monographs on geology and geophysics, 11, Impact cratering: a geologic process. [3] Shoemaker E. M. (1963) The Solar System, 4, 301-336. [4] Poelchau M.H. et al. (2009) JGR, 114, E01006. [5] Settle M., and Head J.W. (1977) Icarus, v. 31, p. 123. [6] McGetchin, T. R., Settle, M. and Head, J. W. 1973. EPSL 20: 226-236. [7] Pike R. J. (1974) EPSL, 23, 265-274. [8] Robinson M.S. et al. (2010) Space Sci. Rev. 150, 81-124.

  10. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available X-ray (Radiography) - Bone What is Bone X-ray (Radiography)? What are some common uses of the procedure? How should I ... X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive medical ...

  11. JAMA Patient Page: Bone Fractures

    Science.gov (United States)

    ... has healed. TYPES OF TREATMENT • Casting—After the broken bones have been manipulated back into their proper positions, a plaster or fiberglass cast is applied to keep the bones from moving while they heal. • External fixation—Pins or wires are set into the bone through the skin ...

  12. Bone metastases: When and how lung cancer interacts with bone

    OpenAIRE

    Roato, Ilaria

    2014-01-01

    Bone metastasis is a common and debilitating consequence of lung cancer: 30%-40% of patients with non-small cell lung cancer develop bone metastases during the course of their disease. Lung cancer cells find a favorable soil in the bone microenvironment due to factors released by the bone matrix, the immune system cells, and the same cancer cells. Many aspects of the cross-talk among lung tumor cells, the immune system, and bone cells are not clear, but this review aims to summarize the recen...

  13. Bone vascularization: a way to study bone microarchitecture?

    Science.gov (United States)

    Blery, P.; Autrusseau, F.; Crauste, E.; Freuchet, Erwan; Weiss, Pierre; Guédon, J.-P.; Amouriq, Y.

    2014-03-01

    Trabecular bone and its microarchitecture are of prime importance for health. Studying vascularization helps to better know the relationship between bone and vascular microarchitecture. This research is an animal study (nine Lewis rats), based on the perfusion of vascularization by a contrast agent (a mixture of 50% barium sulfate with 1.5% of gelatin) before euthanasia. The samples were studied by micro CT at a resolution of 9?m. Softwares were used to show 3D volumes of bone and vessels, to calculate bone and vessels microarchitecture parameters. This study aims to understand simultaneously the bone microarchitecture and its vascular microarchitecture.

  14. Bone island and leprosy

    Energy Technology Data Exchange (ETDEWEB)

    Carpintero, P.; Garcia-Frasquet, A. [Department of Orthopaedic Surgery, Cordoba University, Medical School, Reina Sofia University Hospital, Cordoba (Spain); Tarradas, E. [Department of Imaging, Cordoba University, Medical School, Cordoba (Spain); Logrono, C. [Department of Dermatology, Reina Sofia University Hospital, Cordoba (Spain); Carrascal, A. [Department of Radiology, Infanta Elena Hospital, Huelva (Spain); Carreto, A. [Department of Radiology, Reina Sofia University Hospital, Cordoba (Spain)

    1998-06-01

    Objective. To determine the incidence of bone islands in leprosy patients. Design. X-rays of feet and hands of patients with Hansen`s disease (leprosy) were reviewed retrospectively. A second group of related age- and sex-matched patients who did not have Hansen`s disease was used for control purposes. Controls had undergone hand or foot X-rays during diagnosis of other pathologies. The patients with Hansen`s disease were compared with the control group, and were also analyzed as subgroups with different types of leprosy. The results were subjected to statistical analysis. Patients. Ninety patients with Hansen`s disease were randomly selected for this study. Patients who had had ulcers on hands or feet were excluded from the study. Results and conclusions. Bone islands were demonstrated in 20 patients with Hansen`s disease; no bone islands were observed in the controls. This was statistically significant (P<0.01). Bone islands were only seen in patients with lepromatous leprosy and borderline types but were not demonstrated in patients with tuberculoid leprosy. There was also a statistically significant relationship for a disease duration of 15 years or more. The cause of this raised incidence of enostosis in leprosy patients is not clear, but there may be a genetic predisposition in patients with leprosy, or it may be a side effect of leprosy, especially the lepromatous form. (orig.) With 4 figs., 2 tabs., 9 refs.

  15. Bone scintigraphy in psoriasis

    International Nuclear Information System (INIS)

    Since 1973 bone scintigraphy using sup(99m)Tc-phosphate-complexes was carried out in 382 patients with psoriasis. For comparison with the results of nuclear medicine, roentgenologic and clinical findings a group af 121 patients with psoriasis aged between 11 and 74 years was compared to a group of 42 patients aged between 20 and 49 years without roentgenologic and clinical signs of psoriasis arthritis. We found by means of isotope investigation that an essentially greater part of the bones adjacent to the joints was involved than was expected according to X-ray and clinical findings. In addition, in 205 patients with psoriasis whole-body scintigraphy, using sup(99m)Tc-MDP, was carried out since 1977/78. In 17 patients we found an increased accumulation of activity in the region of extraarticular structures of the skull as well as of the skeletal thorax. According to these results we conclude that in addition to the clinically and roentgenologically defined psoriatic arthritis in patients with psoriasis an osteopathy may exist, which can only be demonstrated by skeletal scintigraphy and which is localized in bones adjacent to the joints but can also be demonstrated in the region of extraarticular bones. (orig.)

  16. Bone scintigraphy in chondroblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Humphry, A.; Gilday, D.L.; Brown, R.G.

    1980-11-01

    Scintigraphy in 3 patients with chondroblastoma showed that the tumors were hyperemic and avidly accumulated the radionuclide. These changes were also present in adjacent normal bone, but to a lesser degree. This suggests that radionuclide uptake in chondroblastoma is a function of the blood supply to the tumor rather than primary matrix extraction.

  17. Paget's disease of bone

    International Nuclear Information System (INIS)

    Nuclear medicine techniques are currently playing an important complementary role in the evaluation, management, and follow-up of the patient who is suspected of having Paget's disease of bone. The earlier diagnoses made possible by some of the described techniques should lead to a better understanding of the basic pathophysiology and, in addition, result in improved therapeutic modalities

  18. Are Bones Alive?

    Science.gov (United States)

    Caravita, Silvia; Falchetti, Elisabetta

    2005-01-01

    Many studies have investigated the classification of living things. Our study deals with a different problem: the attribution of life to one component of a living organism, specifically the bones. The task involves not only specifying what we mean by "alive", but also requires "informed thinking" leading to an understanding of the concept of life…

  19. Temporal bone imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lemmerling, Marc [Algemeen Ziekenhuis Sint-Lucas, Gent (Belgium). Dept. of Radiology; Foer, Bert de (ed.) [Sint-Augustinus Ziekenhuis, Wilrijk (Belgium). Dept. of Radiology

    2015-04-01

    Complete overview of imaging of normal and diseased temporal bone. Straightforward structure to facilitate learning. Detailed consideration of newer imaging techniques, including the hot topic of diffusion-weighted imaging. Includes a chapter on anatomy that will be of great help to the novice interpreter of imaging findings. Excellent illustrations throughout. This book provides a complete overview of imaging of normal and diseased temporal bone. After description of indications for imaging and the cross-sectional imaging anatomy of the area, subsequent chapters address the various diseases and conditions that affect the temporal bone and are likely to be encountered regularly in clinical practice. The classic imaging methods are described and discussed in detail, and individual chapters are included on newer techniques such as functional imaging and diffusion-weighted imaging. There is also a strong focus on postoperative imaging. Throughout, imaging findings are documented with the aid of numerous informative, high-quality illustrations. Temporal Bone Imaging, with its straightforward structure based essentially on topography, will prove of immense value in daily practice.

  20. Temporal bone imaging

    International Nuclear Information System (INIS)

    Complete overview of imaging of normal and diseased temporal bone. Straightforward structure to facilitate learning. Detailed consideration of newer imaging techniques, including the hot topic of diffusion-weighted imaging. Includes a chapter on anatomy that will be of great help to the novice interpreter of imaging findings. Excellent illustrations throughout. This book provides a complete overview of imaging of normal and diseased temporal bone. After description of indications for imaging and the cross-sectional imaging anatomy of the area, subsequent chapters address the various diseases and conditions that affect the temporal bone and are likely to be encountered regularly in clinical practice. The classic imaging methods are described and discussed in detail, and individual chapters are included on newer techniques such as functional imaging and diffusion-weighted imaging. There is also a strong focus on postoperative imaging. Throughout, imaging findings are documented with the aid of numerous informative, high-quality illustrations. Temporal Bone Imaging, with its straightforward structure based essentially on topography, will prove of immense value in daily practice.

  1. Primary leiomyosarcoma of bone

    DEFF Research Database (Denmark)

    Overgaard, Jens; Frederiksen, P

    1977-01-01

    A case of primary leiomyosarcoma of bone in the femur of an 18-year-old girl is described. Light and electron microscopy showed characteristic changes with cytoplasmic myofilaments, dense bodies, pinocytic vesicles and basal lamina fragments. Clinically, the patient is well and without evidence of tumor 9 months after the femur amputation without further treatment.

  2. [Pelvic bone angiomas].

    Science.gov (United States)

    Christ, F; Siemes, H D; Stiens, R

    1984-01-01

    Three patients were seen with angiomas of the pelvic bones; the radiological and clinical features are described and the literature reviewed. The patients had been observed for four to six years. The differential diagnosis includes infiltrating mesenchymal neoplasms and the histologically similar, but rare, Gorham-Stout syndrome. Recommended treatment is irradiation, which is effective up to a point. PMID:6420271

  3. Bone island and leprosy

    International Nuclear Information System (INIS)

    Objective. To determine the incidence of bone islands in leprosy patients. Design. X-rays of feet and hands of patients with Hansen's disease (leprosy) were reviewed retrospectively. A second group of related age- and sex-matched patients who did not have Hansen's disease was used for control purposes. Controls had undergone hand or foot X-rays during diagnosis of other pathologies. The patients with Hansen's disease were compared with the control group, and were also analyzed as subgroups with different types of leprosy. The results were subjected to statistical analysis. Patients. Ninety patients with Hansen's disease were randomly selected for this study. Patients who had had ulcers on hands or feet were excluded from the study. Results and conclusions. Bone islands were demonstrated in 20 patients with Hansen's disease; no bone islands were observed in the controls. This was statistically significant (P<0.01). Bone islands were only seen in patients with lepromatous leprosy and borderline types but were not demonstrated in patients with tuberculoid leprosy. There was also a statistically significant relationship for a disease duration of 15 years or more. The cause of this raised incidence of enostosis in leprosy patients is not clear, but there may be a genetic predisposition in patients with leprosy, or it may be a side effect of leprosy, especially the lepromatous form. (orig.)

  4. Bone marrow oedema associated with benign and malignant bone tumours

    International Nuclear Information System (INIS)

    Bone marrow oedema is associated with a wide variety of pathological processes including both benign and malignant bone tumours. This imaging finding in relation to intraosseous tumours can aid in providing a more focused differential diagnosis. In this review, we will discuss the MR imaging of bone marrow oedema surrounding intraosseous neoplasms. The different pulse sequences used in differentiating underlying tumour from surrounding oedema are discussed along with the role of dynamic contrast enhanced MRI. Benign lesions commonly associated with bone marrow oedema include osteoid osteoma, osteoblastoma, chondroblastoma and Langerhan's cell histiocytosis. Metastases and malignant primary bone tumours such as osteosarcoma, Ewing's sarcoma and chondrosarcoma may also be surrounded by bone marrow oedema. The imaging findings of these conditions are reviewed and illustrated. Finally, the importance of bone marrow oedema in assessment of post chemotherapeutic response is addressed

  5. Bone marrow scintigraphy in Paget's disease of bone

    International Nuclear Information System (INIS)

    Sixteen patients with 20 lesions of Paget's disease of bone were studied with bone marrow scintigraphy (colloid), bone tissue scintigraphy and radiography. Bone marrow scintigraphy showed normal or incrased colloid uptake in 15 of 20 pagetic lesions, and decreased uptake in 4. Bone tissue scintigraphy showed increased metabolic activity in all lesions and was useful in detecting polyostotic disease as well as the extent of the lesions. Conventional radiography most often showed the typical appearance of Paget's disease, but the changes observed were sometimes difficult to differentiate from malignant disease. However, a preserved or increased reticuloendothelial function in the pagetic lesion contradicts metastatic disease as a differential diagnosis. Bone marrow scintigraphy with radiocolloid is a valuable method in the analysis of Paget's disease of bone. (orig.)

  6. Bone scintigraphy in detection of bone invasion by oral carcinoma

    International Nuclear Information System (INIS)

    Detecting osseous involvement is clinically important in the management of oral carcinoma. Thirty-one patients with osseous involvement due to oral carcinoma who underwent panoramic radiography and bone scintigraphy were evaluated retrospectively. Bone scintigraphy confirmed osseous involvement in all 31 (100%) of these patients. In 27 (87%) of 31 patients with osseous involvement, both the panoramic radiogram and bone scintigram were positive. In the remaining four patients (13%), bone scintigram was positive for mandibular or maxillary invasion, while panoramic radiogram was negative. There were no instances of an abnormal radiogram with a normal bone scintigram. These findings strongly suggest that bone scintigraphy is more sensitive than panoramic radiography in detecting osseous involvement of the mandible and maxilla due to oral carcinoma. Furthermore, bone scintigraphy was a critical pre-surgical tool in determining the extent of the osseous involvement. (author)

  7. Bone marrow oedema associated with benign and malignant bone tumours

    Energy Technology Data Exchange (ETDEWEB)

    James, S.L.J. [Department of Radiology, Royal Orthopaedic Hospital, Birmingham, B31 2AP (United Kingdom)], E-mail: steven.james@roh.nhs.uk; Panicek, D.M. [Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 (United States); Davies, A.M. [Department of Radiology, Royal Orthopaedic Hospital, Birmingham, B31 2AP (United Kingdom)

    2008-07-15

    Bone marrow oedema is associated with a wide variety of pathological processes including both benign and malignant bone tumours. This imaging finding in relation to intraosseous tumours can aid in providing a more focused differential diagnosis. In this review, we will discuss the MR imaging of bone marrow oedema surrounding intraosseous neoplasms. The different pulse sequences used in differentiating underlying tumour from surrounding oedema are discussed along with the role of dynamic contrast enhanced MRI. Benign lesions commonly associated with bone marrow oedema include osteoid osteoma, osteoblastoma, chondroblastoma and Langerhan's cell histiocytosis. Metastases and malignant primary bone tumours such as osteosarcoma, Ewing's sarcoma and chondrosarcoma may also be surrounded by bone marrow oedema. The imaging findings of these conditions are reviewed and illustrated. Finally, the importance of bone marrow oedema in assessment of post chemotherapeutic response is addressed.

  8. RIM-DB: a taxonomic framework for community structure analysis of methanogenic archaea from the rumen and other intestinal environments

    Directory of Open Access Journals (Sweden)

    Henning Seedorf

    2014-08-01

    Full Text Available Methane is formed by methanogenic archaea in the rumen as one of the end products of feed fermentation in the ruminant digestive tract. To develop strategies to mitigate anthropogenic methane emissions due to ruminant farming, and to understand rumen microbial differences in animal feed conversion efficiency, it is essential that methanogens can be identified and taxonomically classified with high accuracy. Currently available taxonomic frameworks offer only limited resolution beyond the genus level for taxonomic assignments of sequence data stemming from high throughput sequencing technologies. Therefore, we have developed a QIIME-compatible database (DB designed for species-level taxonomic assignment of 16S rRNA gene amplicon data targeting methanogenic archaea from the rumen, and from animal and human intestinal tracts. Called RIM-DB (Rumen and Intestinal Methanogen-DB, it contains a set of 2,379 almost full-length chimera-checked 16S rRNA gene sequences, including 20 previously unpublished sequences from isolates from three different orders. The taxonomy encompasses the recently-proposed seventh order of methanogens, the Methanomassiliicoccales, and allows differentiation between defined groups within this order. Sequence reads from rumen contents from a range of ruminant-diet combinations were taxonomically assigned using RIM-DB, Greengenes and SILVA. This comparison clearly showed that taxonomic assignments with RIM-DB resulted in the most detailed assignment, and only RIM-DB taxonomic assignments allowed methanogens to be distinguished taxonomically at the species level. RIM-DB complements the use of comprehensive databases such as Greengenes and SILVA for community structure analysis of methanogens from the rumen and other intestinal environments, and allows identification of target species for methane mitigation strategies.

  9. Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch.

    Science.gov (United States)

    Lu, Jun; Machius, Mischa; Dulubova, Irina; Dai, Han; Südhof, Thomas C; Tomchick, Diana R; Rizo, Josep

    2006-07-01

    C(2) domains are well characterized as Ca(2+)/phospholipid-binding modules, but little is known about how they mediate protein-protein interactions. In neurons, a Munc13-1 C(2)A-domain/RIM zinc-finger domain (ZF) heterodimer couples synaptic vesicle priming to presynaptic plasticity. We now show that the Munc13-1 C(2)A domain homodimerizes, and that homodimerization competes with Munc13-1/RIM heterodimerization. X-ray diffraction studies guided by nuclear magnetic resonance (NMR) experiments reveal the crystal structures of the Munc13-1 C(2)A-domain homodimer and the Munc13-1 C(2)A-domain/RIM ZF heterodimer at 1.44 A and 1.78 A resolution, respectively. The C(2)A domain adopts a beta-sandwich structure with a four-stranded concave side that mediates homodimerization, leading to the formation of an eight-stranded beta-barrel. In contrast, heterodimerization involves the bottom tip of the C(2)A-domain beta-sandwich and a C-terminal alpha-helical extension, which wrap around the RIM ZF domain. Our results describe the structural basis for a Munc13-1 homodimer-Munc13-1/RIM heterodimer switch that may be crucial for vesicle priming and presynaptic plasticity, uncovering at the same time an unexpected versatility of C(2) domains as protein-protein interaction modules, and illustrating the power of combining NMR spectroscopy and X-ray crystallography to study protein complexes. PMID:16732694

  10. MR morphology of primary aneurysmal bone cyst: a retrospective analysis of 38 cases

    International Nuclear Information System (INIS)

    Purpose: To define MR imaging characteristics of primary aneurysmal bone cyst. Materials and methods: MR imaging studies of 38 patients with histologically proven primary aneurysmal bone cyst were reviewed with reference to morphological features, signal characteristics, and patterns of contrast-enhancement. Result: Most lesions wer well marginated towards bone and soft issues (95%), either surrounded by a complete (84%) or incomplete (16%) rim of low signal intensity on images of all pulse sequences. Frequent features were polycyclic margins (84%), cortical expansion (87%), cystic spaces (100%), contrast-enhancing cyst walls (100%), internal septations (89%), fluid levels (71%) and diverticula-like projections of cyst walls (68%). Solid tissue components could be identified by MR imaging in all lesions which, on pathological examination, contained larger portions of solid material (18%). Edema of surrounding soft-tissues was observed in 29% of the cases. Conclusions: Primary aneurysmal bone cysts demonstrate a relatively uniform MR imaging appearance, which reflects the patho-anatomic composition of the lesion. (orig.)

  11. Experimental Studies on Diffusion-Controlled rim Growth in the System MgO-SiO2 and in Decarbonation Reactions

    Science.gov (United States)

    Milke, R.; Heinrich, W.; Wiedenbeck, M.; Wunder, B.

    2001-12-01

    The kinetics of subsolidus reactions in rocks are often controlled by grain-boundary diffusion, e.g. the formation of corona structures in metamorphic rocks. During the last decades the modelling of layered corona structures has strongly evolved. The most important information derived from these models are relative migration rates of the involved chemical components. However, the derivation of absolute diffusion rates is largely hampered by uncertainties in the P-T-t paths during rim growth and other unknowns, like the effect of eventual coexisting fluids. Studies on metamorphic reaction rims must therefore by complemented by experiments. In rim growth experiments grain boundary diffusion rates of single components can be measured as functions of pressure, temperature, fluid composition, and matrix phases. Additionally, model concepts can be approved, like attainment of local equilibrium at layer interfaces, reference frames related to interface migration, and microtextural evolution of the rims. We focused on two systems that were already subject of experimental or field studies before: (i) wollastonite rims between calcite and quartz, and (ii) rim growth in the system MgO-SiO2 involving periclase, forsterite, enstatite, and quartz. Wollastonite rim growth was studied in the P-T range from 0.1 to 1 GPa and 850 to 1200oC. The rim formation is interpreted in a volume conserving reference frame. Relative diffusion rates of CaO and SiO2 react sensitively to traces of water. Diffusion in both dry and water-bearing systems is orders of magnitude slower than during rim growth in contact aureoles, however, the growth textures are very similar. Enstatite rim growth around forsterite grains in quartz was studied using isotope tracers and SIMS. The method allowed the exact identification of the enstatite-forming partial reactions and the independent measurement of MgO and Si-diffusion rates. Rim widths are controlled by MgO diffusion, whereas Si is almost immobile. Zoned forsterite-enstatite rims form around periclase grains in quartz. Although there is practically no Si diffusion across the enstatite zone, there is an apparent flux of Si due to migration of the entatite zone into the quartz matrix. Rim growth of this type can only be understood by considering the volume changes during reactions at the layer interfaces.

  12. Aging and bone. X-ray bone densitometry

    International Nuclear Information System (INIS)

    Bone mass at all ages of the individuals is the integration of genetic factors, nutrition, physical exercise, hormonal environments, and other factors influencing the bone. It is also a measurable risk factor for osteoporosis which may subsequently cause bone fractures. Thus measuring bone mass is required to predict the probability of developing bone fractures subsequent to osteoporosis, and to diagnose osteoporosis, and to manage the osteoporosis patient. This paper discusses bone mineral measurements according to their characteristics and clinical application. Methodology for measuring bone mass has rapidly progressed during the past 15 years, which covers photodensitometry, photon absorptiometry (single energy X-ray absorptiometry and dual energy X-ray absorptiometry), quantitative CT, and ultrasound. These techniques have allowed noninvasive measurement of bone mineral density in any site of the skeleton with high accuracy and precision, although a single use of the technique cannot satisfy the complete clinical requirements. Thus the most appropriate method for measuring bone mineral density is important to monitor bone mass change and according to the specific site. (N.K.)

  13. Bone Mineral Density and Bone Metabolism In Children Treated for Bone Sarcomas

    OpenAIRE

    Ruza, E. (Elena); SIERRASESUMAGA, L.; Azcona-San-Julian, M.C. (María Cristina); Patiño, A

    2006-01-01

    In adolescent bone sarcoma patients, bone mass acquisition is potentially compromised at a time in which it should be at a maximum. To evaluate the problem we measured bone mineral density (BMD) and serum markers of bone formation and resorption in a series of pediatric patients with bone tumors. BMD was measured by dual-energy x-ray absorptiometry, at clinical remission, for lumbar spine and the neck of the femur in 38 osteosarcoma and 25 Ewing's sarcoma patients. Mean age was 20.65 and 19.1...

  14. Guided bone regeneration : the influence of barrier membranes on bone grafts and bone defects

    OpenAIRE

    Gielkens, Pepijn Frans Marie,

    2008-01-01

    Guided bone regeneration (GBR) can be described as the use of a barrier membrane to provide a space available for new bone formation in a bony defect. The barrier membrane protects the defect from in-growth of soft tissue cells and allows bone progenitor cells to develop bone within a blood clot that is formed beneath the barrier membrane. Furthermore, the membrane excludes inhibiting factors from outside the defect and preserves bone growth factors inside. GBR was developed in the 1950s and ...

  15. Solid variant of aneurysmal bone cyst of the heel: a case report

    Directory of Open Access Journals (Sweden)

    Stanc-Giannakopoulos Gabriela A

    2011-04-01

    Full Text Available Abstract Introduction An aneurysmal bone cyst is a benign but often rapidly expanding osteolytic multi-cystic osseous lesion that occurs as a primary, secondary, intra-osseous, extra-osseous, solid or conventional lesion. It frequently coexists with other benign and malignant bone tumors. Although it is considered to be reactive in nature, there is evidence that some aneurysmal bone cysts are true neoplasms. The solid variant of aneurysmal bone cyst is a rare subtype of aneurysmal bone cyst with a preponderance of solid to cystic elements. Such a case affecting the heel, an unusual site, is reported. Case presentation A 26-year-old Caucasian man presented with pain and swelling in his left lower extremity. A plain radiograph demonstrated an intra-osseous, solitary, eccentric mass in the front portion of the left heel. Computed tomography and magnetic resonance imaging scans showed that the lesion appeared to be sub-cortical, solid with a small cystic portion without the characteristic fluid-fluid level detection but with distinct internal septation. Bone images containing fluid-fluid levels are usually produced by aneurysmal bone cysts. The fluid-fluid level due to bleeding within the tumor followed by layering of the blood components based density differences, but it was not seen in our case. An intra-lesional excision was performed. Microscopic examination revealed fibrous septa with spindle cell fibroblastic proliferation, capillaries and extensive areas of mature osteoid and reactive woven bone formation rimmed by osteoblasts. The spindle cells had low mitotic activity, and atypical forms were absent. The histological features of the lesion were consistent with the solid variant of an aneurysmal bone cyst. Conclusion Solid aneurysmal bone cysts have been of great interest to pathologists because they may be mistaken for malignant tumors, mainly in cases of giant cell tumors or osteosarcomas, because of cellularity and variable mitotic activity. It is rather obvious that the correlation of clinical, radiological and histological findings is necessary for the differential diagnosis. The eventual diagnosis is based on microscopic evidence and is made when a predominance of solid to cystic elements is found. The present case is of great interest because of the nature of the neoplasm and the extremely unusual location in which it developed. Pathologists must be alert for such a diagnosis.

  16. Dynamic scintigraphy of bone and bone marrow in multiple myeloma patients with bone-marrow transplants

    International Nuclear Information System (INIS)

    Purpose: To determine whether dynamic registration at bone and bone-marrow scintigraphy produces additional information compared to subsequent static registrations of bone-marrow transplants in multiple myeloma patients. Material and Methods: In a prospective study, 8 dynamic bone and 6 dynamic bone-marrow scintigraphies were performed in 10 patients. The dynamic scintigraphies were compared with conventional radiography, MR images, and static scintigraphies of bone and bone marrow. Results: No additional information was revealed by the dynamic registration method; on the contrary, 4 of the 8 known lesions were not discerned at dynamic registration. An incidental observation was that the time-activity curves of both radiopharmaceuticals had a specific pattern. (orig.)

  17. Percutaneous bone biopsy

    International Nuclear Information System (INIS)

    Forty three percutaneous bone biopsy (PBB) procedures were performed under fluoroscopic guide at department of diagnostic radiology of Kosin Medical College, Pusan, Korea. The overall accuracy was 88.4% (38/43) true positive rate was 74% (32 cases), true negative was 14% (6 cases), false negative was 12% (5 cases). In case of suspected metastasis with or without known primary, PBB occasionally provide the final tissue diagnosis and was helpful in tumor staging and seeking the primary site. In cases of primary bone tumor, the tissue diagnosis obtained by PBB was helpful for planning future therapy and confirmed the recurrent tumor and residural lesion following treatment. There was no serious complication related to PBB. In conclusion, PBB is simple, safe, economic and accurated diagnostic tool. PBB gave the final tissue diagnosis. It not only provided accurate tumor staging and future therapeutic plan before treatment and also helped in the management of follow up in patients with recurrent or residural lesion

  18. Benign bone disease

    International Nuclear Information System (INIS)

    This paper discusses how the use of bone imaging in benign disease has advanced rapidly in the past few years. In many instances, we are still only feeling our way in finding the advantages and disadvantages of this procedure in evaluating benign disease. It is to be expected that this process will continue to evolve with further studies of skeletal imaging. Nonetheless, skeletal imaging remains a valuable tool in the study of benign diseases provided good communication is established between the referring clinician and nuclear medicine physician in order to tailor the procedure to answer the clinical question. Attention to technical factors remains all important, as does continuing efforts to increase knowledge concerning the patterns of benign disease that may be presented by bone imaging

  19. Radiotherapy for bone pain

    International Nuclear Information System (INIS)

    Painful bone metastases are a common problem for cancer patients. Although current evidence supports the use of a single fraction of radiotherapy as the treatment of choice, many radiotherapists continue to use fractionated regimens. Over one six month period 105 patients received external beam irradiation for painful bone metastases at the Royal London Hospital (RLH). Thirty-one per cent of the patients were aged 70 or over. The treatment of 97 of these patients was assessed. They had a total of 280 sites treated over the course of their disease. Fifty-nine per cent of sites treated received a fractionated course of radiotherapy. Site significantly influenced fractionation. Overall response rates of 82% were achieved. Fractionation did not appear to influence this. Ten patients received large field irradiation. Fifteen patients had five or more sites irradiated, of whom only one received hemibody irradiation. (author)

  20. Conceptual Study on New Isotope Analysis Technique with Resonance Ionization Mass Spectrometry Using Inductively Coupled Plasma as an Atomic Source (ICP-RIMS)

    International Nuclear Information System (INIS)

    We have proposed the novel isotope analysis technique with Resonance Ionization Mass Spectrometry using Inductively Coupled Plasma as an atomic source (ICP-RIMS). Each component of ICP-RIMS is conceptually designed. We conclude that the orthogonal acceleration time-of-flight mass spectrometer (oa-TOF-MS) driven by a high-repetition-rate pulsed laser would be suitable system for ICP-RIMS. We, additionally, suggest that the first vacuum stage of the vacuum interface, which is between the sampling and skimmer cones, is desired to maintain as low pressure as possible in order to suppress the Doppler broadening and to skim the supersonic jet effectively.