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1

MRI findings in sclerotic bone changes  

Energy Technology Data Exchange (ETDEWEB)

We have compared the value of MRI with conventional radiography and CT in 40 predominantly sclerotic skeletal lesions. We have found that sclerosis and other changes in the bone structure can be demonstrated by MRI in much the same way as with conventional radiography and CT. Using high resolution surface coils, it is possible to demonstrate small areas of new bone formation such as periosteal new bone or the calcification within the nidus of an osteoid osteoma. MRI is particularly appropriate if it is necessary to show soft tissue changes within an area of sclerosis, which may be responsible for the new bone formation and which may be masked on radiographs and CT by the surrounding sclerosis.

Holland, B.R.; Freyschmidt, J.

1988-11-01

2

Localized sclerotic bone response demonstrated reduced nanomechanical creep properties.  

UK PubMed Central (United Kingdom)

Sclerosis (tissue hardening) development is a common occurrence in slow growing or benign osteolytic lesions. However, there is lack of knowledge on the mechanical and material property changes associated with sclerotic bone response. The immune system is postulated to play a relevant role in evoking sclerotic bone responses. In this study, localized sclerotic response in an immunocompetent model of Walker 256 breast carcinoma in SD rats showed an apparent increase in new reactive bone formation. Sclerotic rat femurs had significant increases in bone mineral density (BMD), bone mineral content (BMC), bone volume fraction (BV/TV), bone surface density (BS/TV), trabecular number (Tb.N) and a significant decrease in trabecular separation (Tb.Sp) and structural model index (SMI) as compared to control rat femurs. Significantly reduced creep responses (increased ?) were observed for both trabecular and cortical bone in sclerotic bones while no significant difference was observed in elastic modulus (E) and hardness (H) values. Therefore, we conclude that viscoelastic creep property using nanoindentation would serve as a more sensitive indicator of localized bone modeling than elastic properties. Moreover, reduced viscoelasticity can contribute towards increased microcrack propagation and therefore reduced toughness. Since significant positive correlations between elastic properties (E) and (H) with viscosity (?) were also observed, our results indicate that sclerotic response of bone metastasis would cause reduced toughness (increased ?) with stiffening of material (increased E and H).

Chen X; Goh JC; Teoh SH; De SD; Soong R; Lee T

2013-01-01

3

Sclerotic bone metastases from sarcomatoid renal cell carcinoma  

International Nuclear Information System (INIS)

We present a case of sarcomatoid renal cell carcinoma with multiple sclerotic skeletal metastatic lesions. Renal cell carcinoma is frequently metastatic at presentation, with a high incidence of skeletal involvement, classically described as osteolytic. However, sclerotic or osteoblastic metastatic skeletal lesions from renal cell carcinoma are rare, with only two previous reports identified in the literature, neither of which involved the sarcomatoid variant of renal cell carcinoma. In our case the sclerotic metastases were characterized by bone scan, computed tomography (CT), magnetic resonance imaging (MRI), and histologic analysis. (orig.)

1999-01-01

4

Sclerotic bone metastases from sarcomatoid renal cell carcinoma  

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We present a case of sarcomatoid renal cell carcinoma with multiple sclerotic skeletal metastatic lesions. Renal cell carcinoma is frequently metastatic at presentation, with a high incidence of skeletal involvement, classically described as osteolytic. However, sclerotic or osteoblastic metastatic skeletal lesions from renal cell carcinoma are rare, with only two previous reports identified in the literature, neither of which involved the sarcomatoid variant of renal cell carcinoma. In our case the sclerotic metastases were characterized by bone scan, computed tomography (CT), magnetic resonance imaging (MRI), and histologic analysis. (orig.)

Liu, P.T. [Dept. of Diagnostic Radiology, Mayo Clinic Scottsdale, Scottsdale, AZ (United States); Conley, C.R. [Dept. of Pathology, Mayo Clinic Scottsdale, Scottsdale, AZ (United States); Callstrom, M.R. [Dept. of Diagnostic Radiology, Mayo Clinic Rochester, Rochester, MN (United States)

1999-10-01

5

An unusual image of the temporal bone due to a venous emissary in a sclerotic mastoid.  

UK PubMed Central (United Kingdom)

An unusual image of the temporal bone that is reminiscent of the thumb phalanges is described. This picture is due to an emissary vein in a bilaterally sclerotic mastoid with lateralization of the sigmoid sinus.

Di Segni R; Mazzamurro G; Cascino A; Di Lella V

1980-01-01

6

Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Although the presence of bone marrow lesions (BMLs) on magnetic resonance images is strongly associated with osteoarthritis progression and pain, the underlying pathology is not well established. The aim of the present study was to evaluate the architecture of subchondral bone in regions with and without BMLs from the same individual using bone histomorphometry. METHODS: Postmenopausal female subjects (n = 6, age 48 to 90 years) with predominantly medial compartment osteoarthritis and on a waiting list for total knee replacement were recruited. To identify the location of the BMLs, subjects had a magnetic resonance imaging scan performed on their study knee prior to total knee replacement using a GE 1.5 T scanner with a dedicated extremity coil. An axial map of the tibial plateau was made, delineating the precise location of the BML. After surgical removal of the tibial plateau, the BML was localized using the axial map from the magnetic resonance image and the lesion excised along with a comparably sized bone specimen adjacent to the BML and from the contralateral compartment without a BML. Cores were imaged via microcomputed tomography, and the bone volume fraction and tissue mineral density were calculated for each core. In addition, the thickness of the subchondral plate was measured, and the following quantitative metrics of trabecular structure were calculated for the subchondral trabecular bone in each core: trabecular number, thickness, and spacing, structure model index, connectivity density, and degree of anisotropy. We computed the mean and standard deviation for each parameter, and the unaffected bone from the medial tibial plateau and the bone from the lateral tibial plateau were compared with the affected BML region in the medial tibial plateau. RESULTS: Cores from the lesion area displayed increased bone volume fraction but reduced tissue mineral density. The samples from the subchondral trabecular lesion area exhibited increased trabecular thickness and were also markedly more plate-like than the bone in the other three locations, as evidenced by the lower value of the structural model index. Other differences in structure that were noted were increased trabecular spacing and a trend towards decreased trabecular number in the cores from the medial location as compared with the contralateral location. CONCLUSIONS: Our preliminary data localize specific changes in bone mineralization, remodeling and defects within BMLs features that are adjacent to the subchondral plate. These BMLs appear to be sclerotic compared with unaffected regions from the same individual based on the increased bone volume fraction and increased trabecular thickness. The mineral density in these lesions, however, is reduced and may render this area to be mechanically compromised, and thus susceptible to attrition.

Hunter DJ; Gerstenfeld L; Bishop G; Davis AD; Mason ZD; Einhorn TA; Maciewicz RA; Newham P; Foster M; Jackson S; Morgan EF

2009-01-01

7

Primary bone xanthoma of the inferior orbital rim.  

UK PubMed Central (United Kingdom)

Primary bone xanthoma is an extremely rare benign bone tumor histologically characterized by mononuclear macrophage-like cells, abundant foam cells, and multinucleated giant cells. Xanthomas of the bone usually appear as a benign secondary manifestation of some diseases. Therefore, they are denominated primary xanthomas when the other diseases are discarded.We report a peculiar case of primary bone xanthoma of the inferior orbital rim in the absence of hyperlipidemic conditions. Surgical intervention was performed under local anesthesia via a subtarsal 1-cm incision. Histopathological examination confirmed the diagnosis of bone xanthoma. Primary bone xanthomas are extremely rare. Diagnosis of such lesions is challenging and requires both radiographic and histopathological features assessment. A careful work-up and a full lipid profile should be performed to rule out underlying diseases.

Boffano P; Gallesio C; Campisi P; Benech R; Roccia F; Berrone S

2013-01-01

8

Primary bone xanthoma of the inferior orbital rim.  

Science.gov (United States)

Primary bone xanthoma is an extremely rare benign bone tumor histologically characterized by mononuclear macrophage-like cells, abundant foam cells, and multinucleated giant cells. Xanthomas of the bone usually appear as a benign secondary manifestation of some diseases. Therefore, they are denominated primary xanthomas when the other diseases are discarded.We report a peculiar case of primary bone xanthoma of the inferior orbital rim in the absence of hyperlipidemic conditions. Surgical intervention was performed under local anesthesia via a subtarsal 1-cm incision. Histopathological examination confirmed the diagnosis of bone xanthoma. Primary bone xanthomas are extremely rare. Diagnosis of such lesions is challenging and requires both radiographic and histopathological features assessment. A careful work-up and a full lipid profile should be performed to rule out underlying diseases. PMID:23348334

Boffano, Paolo; Gallesio, Cesare; Campisi, Paola; Benech, Rodolfo; Roccia, Fabio; Berrone, Sid

2013-01-01

9

Bone scintigraphy may help differentiate bone sclerotic lesions from osteoblastic metastases in tuberous sclerosis patients with concomitant pulmonary adenocarcinoma.  

UK PubMed Central (United Kingdom)

Tuberous sclerosis (TS) is a multisystem disorder characterized by widespread hamartomas in multiple organs, including the skeleton. We present a case of bone involvement in a patient with TS and concomitant pulmonary adenocarcinoma. Bone scintigraphy is useful in distinguishing the TS bone lesions from osteoblastic metastases.

Song L; Zhang Y; Zhang W

2013-03-01

10

CT findings of bone metastasis  

International Nuclear Information System (INIS)

[en] Computed tomograms of 150 cases with bone metastasis of various malignant neoplastic diseases are reviewed. According to CT findings bone metastasis is classified into six types, namely osteoblastic, mixed, osteolytic with sclerotic rim, osteolytic with sclerotic center, osteolytic, and infiltrative. Presumably many bone metastases show initially osteoblatic type on CT, and change progressively to mixed type or osteolytic type. If chemotherapy or radiotherapy is effective for bone metastasis, CT demonstrates changes of inverse direction. In detection of bone metastasis CT is superior to radionuclide bone scan. To find out the bone metastasis CT of cancer patients must be evaluated with bone window. (author)

1989-01-01

11

CT findings of bone metastasis  

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Computed tomograms of 150 cases with bone metastasis of various malignant neoplastic diseases are reviewed. According to CT findings bone metastasis is classified into six types, namely osteoblastic, mixed, osteolytic with sclerotic rim, osteolytic with sclerotic center, osteolytic, and infiltrative. Presumably many bone metastases show initially osteoblatic type on CT, and change progressively to mixed type or osteolytic type. If chemotherapy or radiotherapy is effective for bone metastasis, CT demonstrates changes of inverse direction. In detection of bone metastasis CT is superior to radionuclide bone scan. To find out the bone metastasis CT of cancer patients must be evaluated with bone window. (author).

Nosaki, Tadaharu; Murai, Tomoya; Okumura, Akira (National Kure Hospital, Hiroshima (Japan)) (and others)

1989-09-01

12

Detection of Mycobacterium tuberculosis DNA in the sclerotic spinal wall.  

UK PubMed Central (United Kingdom)

Recent studies have shown that the major spinal lesion in spinal tuberculosis is predominantly sclerotic and accounts for >70% of the lesion. In this type of sclerosis, apart from spinal reactive hyperplasia and increased bone density, the most severe lesion is the formation of a hard outer osteoid shell (the sclerotic wall) around the cheese-like substances and granulated tissues. In the current study, polymerase chain reaction detection of Mycobacterium tuberculosis in the sclerotic wall was performed. Surgical specimens were obtained from 18 patients with spinal tuberculosis with peripheral sclerotic wall (as shown by computed tomography) and included the sclerotic wall, subnormal bone tissue outside the sclerotic wall, and iliac bone tissue (control). The IS986 gene in the samples was amplified by polymerase chain reaction followed by DNA sequencing. The obtained sequences were then compared with the published sequences in GenBank using DNATools version 5.1 software (International Centre for Genetic Engineering and Biotechnology, Trieste, Italy). The polymerase chain reaction results showed that 16 specimens from the sclerotic spinal wall, 3 from the subnormal bone, and 0 from the controls were positive for M tuberculosis, indicating a statistically significant difference (P<.05). These results indicated that M tuberculosis was present in the spinal sclerotic wall. Combined with our previous studies, we conclude that the sclerotic wall should be considered a lesion in patients with spinal tuberculosis.

Si J; Geng G; Wang Z

2012-03-01

13

Sclerotic medullary spread in diaphyseal osteosarcoma.  

UK PubMed Central (United Kingdom)

Dense medullary sclerosis is reported in the shafts of long bones accompanying diaphyseal osteosarcoma. Histological evidence suggests that this indicates more extensive medullary spread of tumour than is readily apparent on standard radiographic examination. It would appear that these sclerotic lesions show active radio-isotopes retention following skeletal scintigraphy. The clinical and radiological features and prognostic implications of these findings are discussed.

Haworth JM; McCall IW; Park WM; Watt I

1979-01-01

14

Sclerotic changes of the manubrium sterni  

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Six females with nearly identical sclerotic and hyperostotic changes of the manubrium sterni are reported. Malignancies, bacterial inflammatory processes, and Paget disease, which were first suspected, could be excluded. The youngest patients also had sclerotic changes of other bones, including the lumbar spine, the pubic bone, and the clavicle, and may be classified as having ''chronic recurrent multifocal osteomyelitis'' (CRMO). The two oldest patients had ossification of the costoclavicular ligament(s) and may be classified as having ''inter-sterno-costo-clavicular ossification'' (ISCCO). One had only hyperostotic and sclerotic changes as seen in ''sterno-costo-clavicular hyperostosis'' (SCCH). The pathogenesis of these uncommon diseases is unknown, but they are all frequently associated with pustulosis palmoplantaris and have similar clinical courses and laboratory abnormalities. None of the present patients had HLA-B/sub 27/. The similarity of the radiological abnormalities of the manubrium sterni suggests that the diseases themselves may be similar, but with different courses depending on age, CRMO being present in children and young adults and ISCCO or SCCH in older adults.

Jurik, A.G.; Graudal, H.; De Carvalho, A.

1985-03-01

15

Bone disease of primary hyperoxaluria in infancy  

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A patient with primary hyperoxaluria type I in infancy is reported. He had renal insufficiency, but urolithiasis was absent. Demonstration of diffuse nephrocalcinosis by renal ultrasound contributed to early diagnosis. Prolonged survival leads to extensive extrarenal oxalate deposition. Repeated skeletal surveys showed the development and the progression of severe hyperoxaluria-related bone disease. Translucent metaphyseal bands with sclerotic margins, wide areas of rarefaction at the ends of the long bones, and translucent rims around the epiphyses and the tarsal bones were signs of disordered bone growth. Bone density generally increased with time indicating progressive sclerosis due to oxalate deposition in the previously normal bone structure. (orig.).

Ring, E.; Wendler, H.; Zobel, G. (Graz Univ. (Austria). Abt. fuer Kinderheilkunde); Ratschek, M. (Graz Univ. (Austria). Abt. fuer Pathologie)

1989-11-01

16

Ossifying fibroma of long bones in adults: a case report.  

Science.gov (United States)

Ossifying fibroma (osteofibrous dysplasia) is a rare fibro-osseous lesion made up of fibrous tissue with woven bone formation. It is most commonly found in the tibia and fibula of children ten years of age or younger. The most important differential diagnosis is monostotic fibrous dysplasia, which is radiologically similar but without woven bone rimmed by active osteoblasts like ossifying fibroma on histological examination. No epitheloid cells are found as in adamantinoma. We report the case of a 45-year-old woman who had a 12-month history of pain and slight swelling. Radiographs showed a multilocular radiolucent lesion with sclerotic rim in the proximal tibia. The lesion was curetted and the defect was packed with bone graft and acrylic cement. Microscopic examination showed active osteoblasts rimming the irregulary woven bone. One-year follow-up showed good functional recovery without recurrence of the lesion. PMID:17260623

Almeida Herrero, Fernando; Silvestre Muñoz, Antonio; Martinez Rodriguez, Miguel; Gomar Sancho, Francisco

2006-12-01

17

Sclerotic bodies beyond nephrogenic systemic fibrosis.  

UK PubMed Central (United Kingdom)

Sclerotic bodies are round to oval structures made up of collagen with entrapped elastic fibers, which may be sometimes ossified. These bodies may be found in skin biopsies from patients with nephrogenic systemic fibrosis (NSF), a disease linked to the use of gadolinium in radiologic procedures and chronic renal failure. Sclerotic bodies have not been reported in other diseases. Herein, we report sclerotic bodies as an incidental finding in a re-excision specimen of a squamous cell carcinoma (SCC) from the forearm of an 85-year-old man with chronic renal failure. The patient had had multiple SCC removed over time. Additional clinical history revealed patient having received gadolinium in 2003 and 2004, preceding his dialysis that began in 2009. All of his excision specimens revealed sclerotic bodies in 20 of 30 specimens from 2008. None of the 26 re-excision specimens prior to gadolinium exposure had these bodies. Our findings suggest that sclerotic bodies are the result of gadolinium exposure in patients with chronic renal insufficiency. Because the bodies were found near the re-excision scar, it may be that gadolinium or its metabolites activate fibroblasts in the setting of wound healing. The reasons why this patient did not develop NSF are unclear.

Bhawan J; Perez-Chua TA; Goldberg L

2013-09-01

18

Bone changes in tuberous sclerosis mimicking metastases  

International Nuclear Information System (INIS)

Sclerotic and lytic bone changes of tuberous sclerosis (TS) can mimic bone metastases. A case is reported of a patient with concomitant sclerotic bone metastases from bronchogenic carcinoma and TS bone changes, diagnosed by bone scintigraphy and magnetic resonance imaging. The increased bone uptake and abnormal magnetic resonance signal allowed distinction of TS bone lesions from bone metastases. 6 refs., 4 figs.

1996-01-01

19

Bone changes in tuberous sclerosis mimicking metastases  

Energy Technology Data Exchange (ETDEWEB)

Sclerotic and lytic bone changes of tuberous sclerosis (TS) can mimic bone metastases. A case is reported of a patient with concomitant sclerotic bone metastases from bronchogenic carcinoma and TS bone changes, diagnosed by bone scintigraphy and magnetic resonance imaging. The increased bone uptake and abnormal magnetic resonance signal allowed distinction of TS bone lesions from bone metastases. 6 refs., 4 figs.

Pui, M.H.; Kong Hwai Loong; Choo Hui Fen [National University Hospital (Singapore). Depts. of Diagnostic Radiology and Oncology

1996-02-01

20

Sclerotic Vertebral Metastases: Pain Palliation Using Percutaneous Image-Guided Cryoablation  

International Nuclear Information System (INIS)

Cryoablative therapies have been proposed to palliate pain from soft-tissue or osteolytic bone tumors. A case of a patient with painful thoracic and sacral spine sclerotic metastases successfully treated by image-guided percutaneous cryoablation with the aid of insulation techniques and thermosensors is reported in this case report.

2011-01-01

 
 
 
 
21

Adamantinoma of long bone: radiological findings  

International Nuclear Information System (INIS)

The radiological findings of adamantinomas of long bones are described in 22 patients. In 21 patients the tibia was involved and in one patient the fibula. The tumour was nearly always in the diaphysis (20 cases). The most striking radiological feature was a diaphyseal lesion confined to the bone showing multicentric translucencies. The latter showed surrounding or central ring shaped or focal areas of increased density. The lesions tended to be longitudinal, averaging 11 cm (between 3 and 25 cm). All lesions showed a sclerotic margin separating it from normal bone, at least over part of the lesion. Expanding lesions were mostly separated from the soft tissues by a bony rim (18 cases). (orig./GDG).

1992-01-01

22

Imaging spectrum in sclerotic myelomas: an experience of three cases  

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The classic radiographic presentation of multiple myeloma is lytic skeletal lesions. Primary sclerotic manifestations are rare and occur only in 3 % of cases. The imaging spectrum in three cases of multiple myeloma with primary osteosclerosis is described. The first patient had spiculated sclerosis of the orbit, which is an uncommon site for myeloma. The second patient with POEMS syndrome had multiple, scattered, skeletal lesions with sclerotic margins. The third patient presented with a chest wall mass and had an expansile thick spiculated sclerosis in the rib. The wide imaging spectrum possible in sclerotic myelomas and their relevant differential diagnosis is emphasized. (orig.)

Grover, S.B.; Dhar, A. [Dept. of Radiology, Safdarjang Hospital, New Delhi (India)

2000-11-01

23

Fiber composite flywheel rim  

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A flywheel 2 comprising a hub 4 having at least one radially projecting disc 6, an annular rim 14 secured to said disc and providing a surface circumferential to said hub, a first plurality of resin-impregnated fibers 22 wound about said rim congruent to said surface, and a shell 26 enclosing said first plurality of fibers and formed by a second plurality of resin-impregnated fibers wound about said rim tangentially to said surface.

Davis, Donald E. (Thousand Oaks, CA); Ingham, Kenneth T. (Woodland Hills, CA)

1987-01-01

24

Sclerotic lesions of the cervical spine in sarcoidosis  

Energy Technology Data Exchange (ETDEWEB)

Sarcoidosis is a common multisystem disorder characterized by noncaseating epithelial granulomata, with osseous involvement typically seen in 5% of patients. While the lace-like or cystic pattern frequently seen in radiographs of the phalanges is well appreciated, sclerotic lesions of the spine are uncommon. We review a case of sarcoidosis of the cervical spine with sclerotic changes that mimicked blastic metastatic disease. (orig.) With 1 fig., 11 refs.

Jelinek, J.S. [Department of Radiology, Washington Hospital Center, DC (United States)]|[Uniformed Services University of Health Sciences, Bethesda, MD (United States); Mark, A.S. [Department of Radiology, Washington Hospital Center, DC (United States)]|[Department of Radiology, George Washington University, DC (United States); Barth, W.F. [Section of Rheumatology, Washington Hospital Center, DC (United States)

1998-12-01

25

Adamantinoma of long bone: radiological findings. Radiologische Befunde beim Adamantinom der langen Roehrenknochen  

Energy Technology Data Exchange (ETDEWEB)

The radiological findings of adamantinomas of long bones are described in 22 patients. In 21 patients the tibia was involved and in one patient the fibula. The tumour was nearly always in the diaphysis (20 cases). The most striking radiological feature was a diaphyseal lesion confined to the bone showing multicentric translucencies. The latter showed surrounding or central ring shaped or focal areas of increased density. The lesions tended to be longitudinal, averaging 11 cm (between 3 and 25 cm). All lesions showed a sclerotic margin separating it from normal bone, at least over part of the lesion. Expanding lesions were mostly separated from the soft tissues by a bony rim (18 cases). (orig./GDG).

Bohndorf, K.; Nidecker, A.; Mathias, K.; Zidkova, H.; Kaufmann, H.; Jundt, G. (Deutsches Krebsforschungszentrum, Heidelberg (Germany). Arbeitsgemeinschaft Knochentumoren)

1992-09-01

26

Rim Sign in Acute Cholecystitis  

Energy Technology Data Exchange (ETDEWEB)

The 'rim sign' is a rim of increased hepatic activity adjacent to the gall bladder fossa and known as an useful indicator of acute cholecystitis. Also, many reports suggested that if rim sign is positive there is an increased risk for complications such as perforation and gangrene. To evaluate the usefulness of this rim sign, we reviewed 32 cases that were pathologically confirmed. The incidence of rim sign was 47% similar to other reports but with our results, the rim sign was not specific to acute cholecystitis nor indicator of increased risk for complications.

Koh, Eun Mi; Lee, Kyung Han; Yang, Seoung Oh; Chung, June Key; Lee, Myung Chul; Koh, Chang Soon [Seoul National University College of Medicine, Seoul (Korea, Republic of)

1989-03-15

27

Rim Sign in Acute Cholecystitis  

International Nuclear Information System (INIS)

[en] The 'rim sign' is a rim of increased hepatic activity adjacent to the gall bladder fossa and known as an useful indicator of acute cholecystitis. Also, many reports suggested that if rim sign is positive there is an increased risk for complications such as perforation and gangrene. To evaluate the usefulness of this rim sign, we reviewed 32 cases that were pathologically confirmed. The incidence of rim sign was 47% similar to other reports but with our results, the rim sign was not specific to acute cholecystitis nor indicator of increased risk for complications.

1989-01-01

28

Sclerotic cemental masses of the jaws (so-called chronic sclerosing osteomyelitis, sclerosing osteitis, multiple enostosis, and gigantiform cementoma.  

UK PubMed Central (United Kingdom)

A series of thirty-eight cases of densely sclerotic lesions of the jaws was studied. The lesions were all at least 1.5 cm, in diameter. Pain, drainage, or localized expansion of the jaw was present in two thirds of the patients. Thirty-four of the thirty-eight patients were women, and twenty-five were negros. In fourteen instances, a radiographic survey of the entire jaws was available. Thirteen of these fourteen patients had multiple lesions which were usually symmetrically distributed throughout the jaws. In twenty-four patients radiographs of the lesional area only were available for review. In thirty-four of the thirty-eight cases (89 per cent), the sclerotic masses were interpreted as cementum. Although this condition has previously been described as chronic sclerosing osteomyelitis, sclerosing osteitis, multiple enostosis, or gigantiform cementoma, it appears more appropriate to consider these lesions as part of the spectrum of the benign fibro-osseous lesions of periodontal ligament origin. Four of the sclerotic lesions, which were radiographically indistinguishable from the cemental lesions, consisted only of bone. Two of these appeared to be examples of true chronic sclerosing osteomyelitis, and two may be appropriately designated as enostosis or osteomas.

Waldron CA; Giansanti JS; Browand BC

1975-04-01

29

Pacific rim lures explorationists  

Energy Technology Data Exchange (ETDEWEB)

The Pacific Rim has been far and away the most attractive hunting ground for explorationists in the past year. Observers point to political initiatives coupled with a growing demand as igniting the region's numerous hydrocarbon possibilities. This paper describes some of the new incentives and the resultant exploration results and developments in China, Thailand, Malaysia, Indonesia, and Vietnam. A major sign of the region's political maturity is the willingness for the countries involved to solve the longstanding disputes over the claims in hydrocarbon-prone South China Sea.

Nation, L.

1991-09-01

30

Dopamine-Mediated Sclerotization of Regenerated Chitin in Ionic Liquid  

Directory of Open Access Journals (Sweden)

Full Text Available Chitin is a promising structural material for biomedical applications, due to its many advantageous properties and abundance in nature. However, its usage and development in the biomedical field have been stagnant, because of chitin’s poor mechanical properties in wet conditions and the difficulties in transforming it into an applicable form. To overcome these challenges, we created a novel biomimetic chitin composite. This regenerated chitin, prepared with ionic liquid, showed improved mechanical properties in wet conditions by mimicking insect cuticle and squid beak sclerotization, i.e., catechol-meditated cross-linking. By ionic liquid-based heat treatment, dopamine oxidation produced melanin-like compounds and dopamine-meditated cross-links without any solvent evaporation and oxidant utilization. The dopamine-meditated sclerotization increased the ultimate tensile strength (UTS) of the regenerated chitin by 2.52-fold, measured after six weeks of phosphate-buffered saline (PBS) submersion. In addition, the linear swelling ratio (LSR) of the chitin film was reduced by about 22%. This strategy raises a possibility of using regenerated chitin as an artificial hard tissue in wet conditions.

Dongyeop X. Oh; Sara Shin; Chanoong Lim; Dong Soo Hwang

2013-01-01

31

AVALIAÇÃO HISTOLÓGICA DE FÍGADO, RIM, TIREÓIDE, PARATIREÓIDE E OSSO DE SUÍNOS EM TERMINAÇÃO SUBMETIDOS A DIFERENTES DIETAS HISTOLOGICS AVALUATIONS OF LIVER, KIDNEY, THYROID, PARATHYROID AND METACARPIAN BONE OF FINISHING PIGS WITH DIFFERENT DIETS  

Directory of Open Access Journals (Sweden)

Full Text Available O objetivo do estudo foi avaliar histologicamente fígado, rim, tireóide, paratireóide e osso metacarpo de suínos submetidos a restrições de microminerais, vitaminas e fósforo, e suplementados com a enzima fitase em dois períodos de restrição. Empregaram-se 48 fêmeas suínas com idade inicial de 105 dias (66,15 ± 0,14kg), recebendo dietas experimentais à base de milho e farelos de soja e trigo. Os animais foram agrupados aleatoriamente em seis tratamentos: dieta completa (T1); dieta completa sem suplemento micromineral-vitamínico (T2); dieta sem suplemento micromineral-vitamínico e com fitase (T3); dieta sem suplemento micromineral-vitamínico, sem 1/3 de fósforo inorgânico e com fitase (T4); dieta sem suplemento micromineral-vitamínico, sem 2/3 de fósforo inorgânico e com fitase (T5); dieta sem suplemento micromineral-vitamínico, sem fósforo inorgânico e com fitase (T6). Desenvolveu-se o experimento em duas etapas, sendo a primeira composta por 24 animais, restrição de 35 dias e abate aos 150 dias (106,65 kg), e a segunda, composta por 24 animais, restrição de 60 dias e abate aos 175 dias (123,87 kg). No momento do abate, colheram-se fragmentos de fígado, rim, tireóide, paratireóide e osso metacarpiano de cada animal dos diversos tratamentos. Todos os fragmentos foram fixados em solução de formol tamponado a 10%, processados, incluídos em parafina e corados por hematoxilina e eosina (HE). Empregou-se a coloração especial de tricrômico de Mallory apenas nas amostras ósseas. Ao exame histológico dos rins foram constatados 37 animais com nefrite intersticial (77%). À histologia hepática, observou-se discreto infiltrado inflamatório mononuclear de distribuição predominantemente focal em quinze animais (31,25%). Os tratamentos preconizados não provocaram alterações histológicas nas glândulas paratireóide e tireóide. À microscopia dos ossos metacarpianos, observou-se discreta osteocondrose em animais dos diferentes tratamentos e fases de restrição. Entretanto, durante o período experimental não se registraram quaisquer alterações clínicas relacionadas a doenças metabólicas ósseas ou a osteocondrose. Ainda, de acordo com os resultados, concluiu-se que a fitase foi eficiente em disponibilizar o fósforo fítico da dieta, uma vez que não se observaram lesões ósseas macro e microscópicas características de deficiência de fósforo.PALAVRAS-CHAVES: Alterações histológicas, fitase, restrição de fósforo, vitaminas, microminerais. The present experiment aimed to evaluate histological changes in hepatic, renal, thyroid, parathyroid and metacarpian bone tissues of pigs submitted to diets without micro minerals and vitamins, reduced inorganic phosphorus levels and phytase addition in two restriction times. Forty eight 105-days old (66.15±0.14 kg) female pigs received experimental diets with corn, soybean and wheat meal. The animals were randomly distributed in six groups: standard diets (T1); composed of corn, soybean meal and wheat meal; standard ration without micro mineral and vitamin supplement (T2); T2 ration with phytase (T3); T2 ration reducing 1/3 of inorganic phosphorus with phytase (T4); T2 ration reduced 2/3 of inorganic phosphorus with phytase (T5); and T2 ration with complete reduction of inorganic phosphorus with phytase (T6). The experiment was carried out in two phases: Phase 1. 24 animals, 35 days of restriction and slaughter at 150 days of age (106.65 kg), and Phase 2, 24 animals, 60 days of restriction and slaughter at 175 days of age (123.87 kg). At slaughter, samples of liver, kidney, thyroid, parathyroid and metacarpian bone were collected from all animals. The samples were fixed in 10% buffered formaldehyde and stained by hematoxilin and eosin (HE). The Mallory’s trichrome stain was used in bone sections. Kidney histopathological evaluation showed interstitial nephritis in 37 animals (77%). Mononuclear inflammatory infiltrated was observed focally on liver of 15 animals (31.25%). Treatments didn’t promote histopathologi

Moema Pacheco Chediak Matos; Marina Pacheco Miguel; Veridiana Maria Brianezi Dignani Moura; Jurij Sobestiansky; Luiz Augusto Batista Brito

2008-01-01

32

Rim sign in acute cholecystitis  

International Nuclear Information System (INIS)

[en] This paper determines the cause for the rim sign and to compare the sensitivity of hepatobiliary scintigraphy and US for the diagnosis of acute cholecystitis (AC). The authors compared 15 patients with a definite rim sign to 15 patients without a rim sign. Images of 750,000 counts were taken up to 4 hours after administration of 148 MBq of Tc-99m disofenin. A pathologist evaluated gallbladder (GB) specimens for polymorphonuclear lymphocyte (PMN) infiltration, transmural reaction (TR), and gangrene or other complication (GAN). Liver tissue was attached to the GB specimen in three cases; acute hepatic inflammation was present in the one case with a rim sign but was absent in the two specimens without a rim sign

1990-01-01

33

Development of Natural Culture Media for Rapid Induction of Fonsecaea pedrosoi Sclerotic Cells In Vitro?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fonsecaea pedrosoi is the main agent of chromoblastomycosis, a skin disease presenting verrucous lesions, in which round, thick-walled sclerotic cells are found. In vitro induction of sclerotic cells is time-consuming (20 to 45 days) and temperature dependent. We present two new natural media that r...

da Silva, Moises Batista; da Silva, Jorge Pereira; Sirleide Pereira Yamano, Suellen; Salgado, Ubirajara Imbiriba

34

Imaging features and diagnostic value of bone lipoma  

International Nuclear Information System (INIS)

[en] Objective: To study the imaging manifestations of bone lipoma and their diagnostic value. Methods: Ten cases with pathologically proved lipoma of bone were analyzed, and the literature was reviewed. Results: Eight of 10 cases were intraosseous lipomas which were located in the femoral neck (1 case), the femoral neck-intertrochanter area (1 case), the acetabulum (4 cases) and the calcaneus (2 cases), respectively. All foci showed oval or irregular radiolucent area on X-ray film and adipose tissue area with thin or thick sclerotic rim on CT images. The fat attenuation values within the lesion were in the range of -22 to - 120 Hounsfield units. Focal intralesional calcifications in the center or margin within the intraosseous lipoma were present in 6 foci. The other 2 cases were juxtacortical lipomas, which showed the irregular adipose tissue area beside bone with reactive bony proliferation. Conclusion: The lipoma of bone has common imaging features, that is, mainly composed of fatty tissue. However, the imaging manifestations of bone lipoma in different locations are somewhat different, and they could be diagnosed correctly before operation by using CT. (authors)

2006-01-01

35

Micromorphological and hardness analyses of human and bovine sclerotic dentin: a comparative study  

Directory of Open Access Journals (Sweden)

Full Text Available The purpose of this study was to test the hypothesis that both human and bovine sclerotic dentin have similar hardness properties, in addition to similar micromorphological characteristics. Sixteen teeth (8 human and 8 bovine) exhibiting exposed dentin in the incisal edge and showing characteristics typical of sclerosis were used. Vickers surface microhardness testing was conducted. Three areas of the dentin surface of each specimen were selected. All teeth were processed for scanning electron microscopy in order to estimate the amount (in percentage) of solid dentin on the sclerotic dentin surface. The data were compared by Student's t test (? = 0.05). The micromorphological and microhardness data were compared by Pearson's linear correlation test (? = 0.05). The mean percentages of solid dentin of human and bovine sclerotic dentin were similar (human 90.71 ± 0.83 and bovine 89.08 ± 0.81, p = 0.18). The mean microhardness value (VHN) of human sclerotic dentin was significantly higher than that of bovine sclerotic dentin (human 45.26 ± 2.92 and bovine 29.93 ± 3.83, p = 0.006). No correlation was found between the microhardness values and the amount of solid dentin in the sclerotic dentin, irrespective of the species considered (human R² = 0.0240, p = 0.714; bovine R² = 0.0017, p = 0.923; and combined R² = 0.038, p = 0.46). We concluded that although both bovine and human sclerotic dentin present a similar amount of solid tissue, human sclerotic dentin presents higher microhardness than bovine sclerotic dentin.

Gisela Muassab Castanho; Márcia Martins Marques; Juliana Barbosa Marques; Maitê André Camargo; Antonio Alberto De Cara

2011-01-01

36

The use of qualitative and quantitative polymerase chain reactions for diagnosis of cytomegalovirus infections in bone marrow and kidney transplant recipients Desenvolvimento e aplicação de PCRs quali-quantitativas para diagnóstico de citomegalovirose em transplantados de rim e medula óssea  

Directory of Open Access Journals (Sweden)

Full Text Available The purpose of this work was to test a cytomegalovirus qualitative PCR and a semi-quantitative PCR on the determination of CMV load in leukocytes of bone marrow and kidney transplanted (RT) patients. Thirty three BMT and 35 RT patients participated of the study. The DNA was subjected to a qualitative PCR using primers that amplify part of CMV gB gene. CMV load of positive samples was determined by a semi-quantitative PCR using quantified plasmids inserted with part of the gB gene of CMV as controls. The sensitivity of the test was determined to be 867 plasmid copies/µg DNA. CMV loads between 2,118 and 72,443 copies/µg DNA were observed in 12.1% BMT recipients and between 1,246 and 58,613 copies/µg DNA in 22.9% RT recipients. Further studies are necessary to confirm the usefulness of this CMV semi-quantitative PCR in transplanted patients.O objetivo deste trabalho foi testar uma PCR qualitativa e uma PCR semiquantitativa para CMV para determinar a carga de CMV nos leucócitos de pacientes transplantados de medula óssea e transplantados de rim. Trinta e três pacientes TMO e 35 TR participaram deste estudo. O DNA foi testado pela PCR qualitativa utilizando primers que amplificam parte do gene gB de CMV. As cargas de CMV das amostras positivas foram determinadas pela PCR semi-quantitativa utilizando como controle plasmídios quantificáveis inseridos com parte do gene gB de CMV. A sensibilidade do teste foi de 867 plamídios/µg DNA. Cargas de CMV entre 2.118 e 72.443 copias/µg DNA foram observadas em 12,1% dos TMO entre 1,246 e 58,613 cópias/µg DNA foram observadas em 22,9% dos TR. Futuros estudos, com maiores casuísticas são necessários para confirmar a utilidade desta PCR semiquantitativa para CMV em pacientes transplantados.

Lauro Juliano Marin; Aldo Albuquerque Cunha; Victor Hugo Aquino; Luiz Tadeu Moraes Figueiredo

2004-01-01

37

Portable basketball rim testing device  

Energy Technology Data Exchange (ETDEWEB)

A portable basketball rim rebound testing device 10 is illustrated in two preferred embodiments for testing the rebound or energy absorption characteristics of a basketball rim 12 and its accompanying support to determine likely rebound or energy absorption charcteristics of the system. The apparatus 10 includes a depending frame 28 having a C-clamp 36 for releasably rigidly connecting the frame to the basketball rim 12. A glide weight 60 is mounted on a guide rod 52 permitting the weight 60 to be dropped against a calibrated spring 56 held on an abutment surface on the rod to generate for deflecting the basketball rim and then rebounding the weight upwardly. A photosensor 66 is mounted on the depending frame 28 to sense passage of reflective surfaces 75 on the weight to thereby obtain sufficient data to enable a processing means 26 to calculate the rebound velocity and relate it to an energy absorption percentage rate of the rim system 12. A readout is provided to display the energy absorption percentage.

Abbott, W. Bruce (610 Clover St., Cheney, WA 99004); Davis, Karl C. (Box 722, Richland, WA 99352)

1993-01-01

38

Proceedings, Pacific Rim congress 87  

Energy Technology Data Exchange (ETDEWEB)

Papers were presented covering the geology, structure, mineralisation and economics of the Pacific Rim. Student competition papers and papers presented at the Mining Industry Consultants Association of Australia seminar are included. Papers included: the Matakan unit in the Lelet limestone, a New Ireland (Papua New Guinea) coal and carbonaceous sediments; a geostatistical approach to coal reserve classification; and the tectonic setting of Permian coal basins of Eastern Australia.

1987-01-01

39

CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS  

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Full Text Available Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fingers have not been reported to date. Mucin deposition in the sclerotic skin may be a predisposing factor in the induction of myxoid cyst on the scleroderma finger in our patient.

Taeko Nakamura-Wakatsuki; Toshiyuki Yamamoto

2013-01-01

40

Anterior glenoid rim fracture: the value of helical CT with threedimensional reconstruction and electronic humeral disarticulation  

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Full Text Available Objectives: To show a new three-dimensional reconstructiontechnique based on helical computed tomography images withelectronic humeral disarticulation in anterior glenoid rim fractures,correlating the anatomic specimen with simulation of an anteriorglenoid rim fracture, as well as evaluating the extension of thefracture, the bone fragment position and distance in relation to theglenoid cavity in six patients. Methods: One scapula and onehumerus with no signs of fracture or congenital malformationswere placed in anatomical position using an adhesive tape aftersimulating an anterior glenoid rim fracture made by an osteotome.Helical CT imaging was acquired and three-dimensionalreconstructions were made based on these images, with andwithout electronic humeral disarticulation. The bone fragment waslocated, measured and its position in relation to the glenoid cavitywas assessed. Six patients with anterior glenoid rim fracture weresubmitted to CT of the shoulder using the same parameters asthose applied to the anatomic specimen. Results: In the anatomicspecimen and in all six patients the bone fragment was clearlydemonstrated; bone fragment measurements in the anatomicspecimen and in three-dimensional reconstructions wereequivalent. The fragment was better demonstrated in the imagestaken with electronic humeral disarticulation, particularly in thefrontal view of the glenoid cavity as observed in all six patients.Conclusion: We concluded that our experiment with the anatomicspecimen and the study of six patients allow us to state that thistechnique is safe and accurate to demonstrate the extension, sizeand location of the bone fragment in anterior glenoid rim fractures,and it provides essential elements for therapeutic planning.

Heverton César de Oliveira; Luís Cesar Paiva; Lúcio Cesar Silva Righi

2003-01-01

 
 
 
 
41

Solitary infantile myofibromatosis of bone. An immunohistochemical and ultrastructural study.  

UK PubMed Central (United Kingdom)

A rare case of solitary infantile myofibromatosis of bone in an 11-month-old boy is reported. Radiographically the lesion of parietal bone was round, well-circumscribed, and osteolytic with a sclerotic rim. Histologically the tumor was made up of nodules that were hyalinized or cellular and containing plump, spindle-shaped cells that were intermediate in appearance between fibroblasts and smooth-muscle cells, arranged in short bundles or whorls. Another typical feature was the presence of distended, cleft-shaped vascular spaces around the nodules. The microscopic features of this tumor were consistent with those of infantile myofibromatosis of other sites, such as the skin and deep soft tissue. The tumor cells showed immunoreactivities for vimentin and alpha-smooth muscle actin. Microfilaments with dense bodies were observed in the fibroblast-like tumor cells. In addition, many tumor cells stained for collagen type IV and were covered by incomplete external laminae, indicating infantile myofibromatosis has more advanced smooth-muscle differentiation than conventional fibromatosis.

Hasegawa T; Hirose T; Seki K; Hizawa K; Okada J; Nakanishi H

1993-03-01

42

Parietal Epithelial Cells Participate in the Formation of Sclerotic Lesions in Focal Segmental Glomerulosclerosis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The pathogenesis of the development of sclerotic lesions in focal segmental glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or parietal epithelial cells (PECs) to determine whether PECs contribute to sclerosis. In three distinct models of FSGS (5/6-nephrectomy + DOCA...

Smeets, Bart; Kuppe, Christoph; Sicking, Eva-Maria; Fuss, Astrid; Jirak, Peggy; van Kuppevelt, Toin H.; Endlich, Karlhans

43

Quantification of sclerotic renal glomeruli during the aging process in humans  

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Full Text Available Introduction. The aim of our research was to quantify the presence of totally sclerotized glomeruli during the aging process. Material and Methods. The study material were kidney tissue samples taken from fiftysix cadavers, their age ranging from 20 to over 70 years. They were classified in six age groups: I (20-29), II (30-39), III (40-49); IV (50-59); V (60-69) and VI (older than 70). The tissue samples were routinely histologically processed and then cut into the slices 5 mm thick, which were then stained and stereologically analyzed under the microscope with a projection screen (Reichert Visopan) with 10 x lens magnification and multipurpose test system M42 application. The analysis was carried out on 20 fields of vision per one sample. The numerical density of completely sclerotic and other glomeruli was measured, and the resulting percentages were obtained from this parameter. Results. Completely sclerotic glomeruli were not found in the first group. They were observed in the II aging group (5%) for the first time. Their numerical density and percentage increased during the aging process and was 18% in the IV, 25% in the V and maximally 37.5% in the VI aging group. Conclusion. Finally, the above cited results pointed to the increase of completely sclerotized and the decreased presence of normal glomeruli during the aging process

Stojanovi? Vesna; Jovanovi? Ivan; Ugrenovi? Sla?ana; Pavlovi? Snežana

2010-01-01

44

Collagenous fibroma (desmoplastic fibroblastoma) of the orbital rim.  

UK PubMed Central (United Kingdom)

A 40-year-old woman with left periorbital swelling for 1 month presented without diplopia or change in vision. Imaging studies revealed a 1-cm mass at the frontozygomatic junction at the orbital rim with slight bony erosion and spiculation. The lesion was applied to the periosteum and was excised along with a portion of the bony orbital rim. Histopathology revealed elongated and stellate fibroblasts within a dense collagenous matrix. Vimentin and Masson trichrome staining was consistent with a collagenous fibroma, a rare tumor that has, only once before, been reported in the orbit in the lacrimal fossa region. The current collagenous fibroma arose from the periosteum to grow exophytically, causing minimal bone changes. A literature review shows that this condition predominantly affects middle-aged and older adults rather than children.

Stacy RC; Jakobiec FA; Fay A

2013-07-01

45

High ionization efficiency techniques for CW RIMS  

Energy Technology Data Exchange (ETDEWEB)

The demand to measure high dynamic range isotope ratios on small samples with RIMS continues to increase. This paper discusses high ionization efficiency methods which can be applied to CW RIMS to potentially achieve several tens of percent ionization efficiencies for certain elements. The primary technique under development to achieve this is an external laser cavity which can generate very high circulating laser powers.

Fearey, B.L.; Johnson, S.G.; Miller, C.M.

1990-01-01

46

A fight for neurotransmission: SCRAPPER trashes RIM.  

UK PubMed Central (United Kingdom)

The presynaptic scaffold molecule RIM1alpha is important for regulating neurotransmitter release. In this issue, Yao et al. (2007) show in mice that an E3 ubiquitin ligase, SCRAPPER, targets a set of presynaptic proteins including RIM1alpha for degradation by the ubiquitin-proteasome system. Their results identify protein degradation as a mechanism for holding rapid synaptic communication in check.

Dobie F; Craig AM

2007-09-01

47

The Pacific Rim Library: A Surprising Pearl  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Pacific Rim Library (PRL) is an initiative of the Pacific Rim Digital Library Association (PRDLA). The project began in 2006 using the OAI-PMH paradigm and now holds over 300,000 records harvested from OAI data provider libraries around the Pacific. PRL's goal is to enable the sharing of digital...

Palmer, DT

48

RIMS [Records Inventory Management System] Handbook  

International Nuclear Information System (INIS)

[en] The Records Inventory Management System (RIMS) is a computer library of abstracted documents relating to low-level radioactive waste. The documents are of interest to state governments, regional compacts, and the Department of Energy, especially as they relate to the Low-Level Radioactive Waste Policy Act requiring states or compacts of states to establish and operate waste disposal facilities. RIMS documents are primarily regulatory, policy, or technical documents, published by the various states and compacts of the United States; however, RIMS contains key international publications as well. The system has two sections: a document retrieval section and a document update section. The RIMS mainframe can be accessed through a PC or modem. Also, each state and compact may request a PC version of RIMS, which allows a user to enter documents off line and then upload the documents to the mainframe data base

1989-01-01

49

Morphology of autogenous bone graft and castor oil polyurethane in the infraorbital rim of rabbits: a comparative study Estudo morfológico comparativo do enxerto ósseo autógeno e polímero de mamona em rebordo infra-orbitário de coelhos  

Directory of Open Access Journals (Sweden)

Full Text Available PURPOSE: Morphological study comparing castor oil polyurethane and autogenous bone graft to repair bone defect in zygomatic bone of rabbits. METHODS: Twenty-four adult, male New Zealand rabbits were randomly distributed between two groups of twelve. Bone defects of 5mm in diameter were cut through the zygomatic bone and filled with polyurethane discs in the experimental group or autogenous bone harvested from the tibia in the control group. Animals were sacrificed after 30, 60 or 90 days, and the zygomatic bones were macro- and microscopically analyzed. Student's, Fisher's, chi-squared and McNemar's tests were used for statistical analysis. RESULTS: Both the castor oil polyurethane and the autograft adapted well to the defect, with no need for fixation. Fibrous connective tissue encapsulated the polyurethane, but no inflammation or giant cell reaction was observed. Acidophilic and basophilic areas were observed inside the micropores of the polyurethane, suggesting cell nuclei. After 90 days, bone repair with a lamellar pattern of organization was observed in the control group. CONCLUSION: The castor oil polyurethane was biocompatible and did not cause inflammation. It may be considered an alternative to fill bone defects.OBJETIVO: Estudo morfológico comparativo do implante de poliuretana de mamona e enxerto ósseo autógeno em defeito ósseo padrão em osso zigomático de coelhos. MÉTODOS: Vinte e quatro coelhos Nova Zelândia, machos, adultos, foram distribuídos aleatoriamente em dois grupos de 12. Defeitos de 5mm de diâmetro, perenes, foram confeccionados em osso zigomático e preenchidos com discos pré-fabricados de poliuretana no grupo experimento ou osso autógeno extraído da tíbia no grupo controle. Os animais foram sacrificados após 30, 60 e 90 dias e as peças anatômicas foram avaliadas macro e microscopicamente. Foram utilizados os testes de Student, Fisher,qui-quadrado e McNemar para a análise estatística dos resultados. RESULTADOS: A poliuretana e o osso autógeno se adaptaram ao defeito sem necessidade de fixação. Houve formação de tecido conjuntivo fibroso envolvendo a poliuretana, sem reação inflamatória ou presença de células gigantes. Verificaram-se áreas acidófilas e basófilas nos poros do material implantado, sugestivas de núcleos celulares. No grupo controle, observou-se aos 90 dias o reparo ósseo de padrão lamelar clássico. CONCLUSÃO: A poliuretana de mamona foi biocompatível e não causou reação inflamatória deletéria. Pode ser uma alternativa para o preenchimento de defeitos ósseos.

José Carlos Garcia de Mendonça; Rafael De Rossi; Celso Massaschi Inouye; Diego Rodrigo Paulillo Bazan; João Carlos Castro Monteiro; Juliana Pedroso de Mendonça

2006-01-01

50

Surgical Management of Myxoma Like Sclerotic Calcified Mass in Left Ventricle Outflow Tract  

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Full Text Available In this short report, we present the succesfull surgical traetment of a patient who had an echocardiographic diagnosis of left ventricular mass during her routine controls. This patient was treated by surgical excision of the ventricular mass and after the pathological examination the diagnosis was “myxoma like sclerotic calcified mass”. The postoperative course was uneventful, and the patient was discharged on day 7 of surgery. The follow-up period lasted for 2 years without any event and the echocardiograms revelaed no residual or reccurrent lesions. Surgical resection of intracardiac masses are necessary and safe treatment options but there is not a standardization about the type of surgical options. The localization of the mass has the key role in determining the type of the surgical approach. In this case, aortotomy provided a good access and facilitated the exposure of this rare myxoma like sclerotic calcified mass.

Atilla Sezgin; Hakk? Tankut Akay; Oktay Korun; Bahad?r Gültekin; Banu Bilezikçi

2011-01-01

51

Vanishing bone metastases--a pitfall in the interpretation of contrast enhanced CT in patients with superior vena cava obstruction.  

Science.gov (United States)

We describe a previously unreported case of vertebral marrow enhancement owing to collateral circulation in a patient with superior vena cava obstruction. Failure to recognise this phenomenon led to the misdiagnosis of sclerotic bone metastases. PMID:21849358

Thomas, N; Oliver, T B; Sudarshan, T

2011-09-01

52

Rim sign: association with acute cholecystitis  

Energy Technology Data Exchange (ETDEWEB)

In a retrospective analysis of 218 hepatobiliary studies in patients clinically suspected of acute cholecystitis, a rim of increased hepatic activity adjacent to the gallbladder fossa (the rim sign) has been evaluated as a scintigraphic predictor of confirmed acute cholecystitis. Of 28 cases with pathologic confirmation of acute cholecystitis in this series, 17 (60%) demonstrated this sign. When associated with nonvisualization of the gallbladder at 1 hr, the positive predictive value of this photon-intense rim for acute cholecystitis was 94%. When the rim sign was absent, the positive predictive value of nonvisualization of the gallbladder at 1 hr for acute cholecystitis was only 36%. As this sign was always seen during the first hour postinjection, it can, when associated with nonvisualization, reduce the time required for completion of an hepatobiliary examination in suspected acute cholecystitis.

Bushnell, D.L.; Perlman, S.B.; Wilson, M.A.; Polcyn, R.E.

1986-03-01

53

Rim sign: association with acute cholecystitis  

International Nuclear Information System (INIS)

[en] In a retrospective analysis of 218 hepatobiliary studies in patients clinically suspected of acute cholecystitis, a rim of increased hepatic activity adjacent to the gallbladder fossa (the rim sign) has been evaluated as a scintigraphic predictor of confirmed acute cholecystitis. Of 28 cases with pathologic confirmation of acute cholecystitis in this series, 17 (60%) demonstrated this sign. When associated with nonvisualization of the gallbladder at 1 hr, the positive predictive value of this photon-intense rim for acute cholecystitis was 94%. When the rim sign was absent, the positive predictive value of nonvisualization of the gallbladder at 1 hr for acute cholecystitis was only 36%. As this sign was always seen during the first hour postinjection, it can, when associated with nonvisualization, reduce the time required for completion of an hepatobiliary examination in suspected acute cholecystitis

1986-01-01

54

RIMS (Records Inventory Management System) Handbook.  

Science.gov (United States)

The Records Inventory Management System (RIMS) is a computer library of abstracted documents relating to low-level radioactive waste. The documents are of interest to state governments, regional compacts, and the Department of Energy, especially as they r...

1989-01-01

55

Linhas escleróticas metafisárias em crianças e adolescentes em uso de alendronato Sclerotic metaphyseal lines in children and adolescents treated with alendronate  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUÇÃO: Os bisfosfonatos inibem a reabsorção óssea pela interferência na ação dos osteoclastos. Dentre os efeitos adversos, as linhas escleróticas em metáfise de ossos longos são descritas como principal alteração radiográfica na faixa etária pediátrica. OBJETIVO: Avaliar a frequência de alterações radiográficas causadas pelo alendronato utilizado em crianças e adolescentes com baixa densidade óssea ou calcinose. PACIENTES E MÉTODOS: Foi realizado um estudo do tipo coorte retrospectiva analisando-se prontuários de 21 pacientes que fizeram uso de alendronato semanal por no mínimo 10 meses. Os pacientes realizaram radiografias de ossos longos antes do início do alendronato e aproximadamente um ano após o seu uso. RESULTADOS: Onze pacientes (52,3%) apresentaram linhas escleróticas em metáfise dos ossos longos. A localização mais frequente foi em tíbia (8/11 pacientes), seguida de fêmur (7/11), úmero (6/11), rádio (4/11), ulna (3/11) e fíbula (2/11). Nenhum paciente apresentou regressão das alterações radiográficas durante o tempo de evolução (até 1,1 ano após a suspensão do alendronato). CONCLUSÃO: Se usado com critério, o alendronato é seguro e as alterações radiográficas não mostraram ter um significado mais importante.INTRODUCTION: Bisphosphonates inhibit bone resorption by interfering with the action of osteoclasts. Among the adverse effects, sclerotic lines observed in the metaphysis of long bones have been described as the main imaging finding in pediatric patients. OBJECTIVE: To evaluate the frequency of radiographic changes caused by alendronate in children and adolescents with low bone density or calcinosis. PATIENTS AND METHODS: We conducted a cross-sectional study with 21 patients who were treated with once-weekly alendronate for at least 10 months. Patients underwent x-rays of long bones before the start of alendronate and approximately one year after its use. RESULTS: Eleven patients (52.3%) had sclerotic lines in the metaphysis of long bones. The most frequent site was the tibia (8/11 patients), followed by the femur (7/11), humerus (6/11), radius (4/11), ulna (3/11), and fibula (2/11). Regression of radiographic changes during the study period (up to 1.1 years after discontinuation of alendronate) was not observed. CONCLUSION: If used carefully, alendronate is safe and radiographic changes have not been shown to be clinically relevant.

Érika C.C. Silva; Maria Teresa R.A. Terreri; Tania C.M. de Castro; Cássia P.L. Barbosa; Artur R.C. Fernandes; Maria Odete E. Hilário

2010-01-01

56

Osteoblastic metastases from breast carcinoma with false-negative bone scan  

Energy Technology Data Exchange (ETDEWEB)

The authors report a case of metastatic breast carcinoma that on investigation was shown to have a negative bone scan in spite of multiple densely sclerotic metastases on radiography and CT and a positive bone biopsy. The literature is reviewed with regard to the subject of negative bone scans in this situation. (orig.). With 3 figs.

Munk, P.L. [Department of Radiology, Vancouver Hospital and Health Sciences Center, The University of British Columbia, Vancouver, BC (Canada); Poon, P.Y. [Department of Diagnostic Imaging, British Columbia Cancer Agency - Vancouver Cancer Center, The University of British Columbia, Vancouver, BC (Canada); O`Connell, J.X. [Department of Pathology, Vancouver Hospital and Health Sciences Center, The University of British Columbia, Vancouver, BC (Canada); Janzen, D. [Department of Radiology, Vancouver Hospital and Health Sciences Center, The University of British Columbia, Vancouver, BC (Canada); Coupland, D. [Division of Nuclear Medicine, Vancouver Hospital and Health Sciences Center, The University of British Columbia, Vancouver, BC (Canada); Kwong, J.S. [Division of Nuclear Medicine, Vancouver Hospital and Health Sciences Center, The University of British Columbia, Vancouver, BC (Canada); Gelmon, K. [Department of Medical Oncology, British Columbia Cancer Agency - Vancouver Cancer Center, The University of British Columbia, Vancouver, BC (Canada); Worsley, D. [Division of Nuclear Medicine, Vancouver Hospital and Health Sciences Center, The University of British Columbia, Vancouver, BC (Canada)

1997-07-07

57

Automated detection of sclerotic metastases in the thoracolumbar spine at CT.  

UK PubMed Central (United Kingdom)

PURPOSE: To design and validate a computer system for automated detection and quantitative characterization of sclerotic metastases of the thoracolumbar spine on computed tomography (CT) images. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board and was HIPAA compliant; informed consent was waived. The data set consisted of CT examinations in 49 patients (14 female, 35 male patients; mean age, 57.0 years; range, 12-77 years), demonstrating a total of 532 sclerotic lesions of the spine of greater than 0.3 cm(3) in volume, and in 10 control case patients (four women, six men; mean age, 55.2 years; range, 19-70 years) without spinal lesions. CT examinations were divided into training and test sets, and images were analyzed according to prototypical fully-automated computer-aided detection (CAD) software. Free-response receiver operating characteristic analysis was performed. RESULTS: Lesion detection sensitivity on images in the training set was 90%, relative to reference-standard marked lesions (95% confidence interval [CI]: 83%, 97%), at a false-positive rate (FPR) of 10.8 per patient (95% CI: 6.6, 15.0). For images in the testing set, sensitivity was 79% (95% CI: 74%, 84%), with an FPR of 10.9 per patient (95% CI: 8.5, 13.3). False-negative findings were most commonly (37 [40%] of 93) a result of endplate proximity, with 32 (34% of 93) caused by low CT attenuation. Marginal sclerosis caused by degenerative change (174 [28.1%] of 620 actual detections) was the most common cause of false-positive detections, followed by partial volume averaging with vertebral endplates (173 [27.9%] of 620) and pedicle cortex parallel to the axial imaging plane (121 [19.5%] 620). CONCLUSION: This CAD system successfully identified and segmented sclerotic lesions in the thoracolumbar spine.

Burns JE; Yao J; Wiese TS; Muñoz HE; Jones EC; Summers RM

2013-07-01

58

Laccase2 is required for sclerotization and pigmentation of Aedes albopictus eggshell.  

Science.gov (United States)

Laccase (EC 1.10.3.2) is a member of multicopper oxidases that have been found in higher plants, fungus, bacterium, and insects. Two types of laccase genes have been detected in many species of insects: laccase1 and laccase2. It has been identified that laccase2 enzyme may play a key role in sclerotization and pigmentation of insect cuticle. But few attentions were given to the biological role of laccase2 in the synthesizing of similar structures, such as oothecae, eggshell, or silk cocoons. We cloned laccase2 gene from Aedes albopictus, one main mosquito vector of dengue virus in China. An upregulation of laccase2 gene was observed after a blood meal in female adult mosquitoes, suggesting that laccase2 gene may have an involvement in the development of ovary. RNA interference experiment was performed by using adult female mosquitoes. Female mosquitoes were injected with 20 ng of double-strain RNA into the thorax. Pigmentation of mosquito eggshell was blocked that these eggs never became dark. And the incomplete sclerotization of eggshell weakened the stability and flexibility of the eggs. These eggs without enough protection were deformed and died in water. These results demonstrate that laccase2 plays a critical role in the development of eggs of A. albopictus. Laccase2 may provide a novel target for mosquito control and management. PMID:23455937

Wu, Xiansheng; Zhan, Ximei; Gan, Ming; Zhang, Dongjing; Zhang, Meichun; Zheng, Xiaoying; Wu, Yu; Li, Zhuoya; He, Ai

2013-03-01

59

Laccase2 is required for sclerotization and pigmentation of Aedes albopictus eggshell.  

UK PubMed Central (United Kingdom)

Laccase (EC 1.10.3.2) is a member of multicopper oxidases that have been found in higher plants, fungus, bacterium, and insects. Two types of laccase genes have been detected in many species of insects: laccase1 and laccase2. It has been identified that laccase2 enzyme may play a key role in sclerotization and pigmentation of insect cuticle. But few attentions were given to the biological role of laccase2 in the synthesizing of similar structures, such as oothecae, eggshell, or silk cocoons. We cloned laccase2 gene from Aedes albopictus, one main mosquito vector of dengue virus in China. An upregulation of laccase2 gene was observed after a blood meal in female adult mosquitoes, suggesting that laccase2 gene may have an involvement in the development of ovary. RNA interference experiment was performed by using adult female mosquitoes. Female mosquitoes were injected with 20 ng of double-strain RNA into the thorax. Pigmentation of mosquito eggshell was blocked that these eggs never became dark. And the incomplete sclerotization of eggshell weakened the stability and flexibility of the eggs. These eggs without enough protection were deformed and died in water. These results demonstrate that laccase2 plays a critical role in the development of eggs of A. albopictus. Laccase2 may provide a novel target for mosquito control and management.

Wu X; Zhan X; Gan M; Zhang D; Zhang M; Zheng X; Wu Y; Li Z; He A

2013-05-01

60

Carcinoma medular do rim Renal medullary carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available É relatado caso de paciente de 24 anos, portador de traço falciforme, com imagem sólida no rim direito, submetido a nefrectomia radical que revelou tumor, cujo exame anatomopatológico permitiu o diagnóstico de carcinoma medular do rim. Os autores discutem aspectos dessa neoplasia, tais como freqüência, patogênese, apresentação clínica, histopatologia e evolução.We report the case of a 24-year-old patient who presented a left kidney tumor that was diagnosed as a medullary renal cell carcinoma. The following aspects of this neoplasia are discussed in this communication: frequency, pathogenesis, clinical presentation, histopathological findings, differential diagnosis and follow-up.

Paulo Guilherme de Oliveira Salles; Dairton Miranda; Arnaldo Jonas Pimentel Seleiro; José Ribamar Castelo Branco

2006-01-01

 
 
 
 
61

Rimmed and edge thickened Stodola shaped flywheel  

Energy Technology Data Exchange (ETDEWEB)

A flywheel (10) is described that is useful for energy storage in a hybrid vehicle automotive power system or in some stationary applications. The flywheel (10) has a body (15) composed of essentially planar isotropic high strength material. The flywheel (10) body (15) is enclosed by a rim (50) of circumferentially wound fiber (2) embedded in resin (3). The rim (50) promotes flywheel (10) safety and survivability. The flywheel (10) has a truncated and edge thickened Stodola shape designed to optimize system mass and energy storage capability.

Kulkarni, Satish V. (San Ramon, CA); Stone, Richard G. (Oakland, CA)

1983-01-01

62

Carcinoma medular do rim/ Renal medullary carcinoma  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese É relatado caso de paciente de 24 anos, portador de traço falciforme, com imagem sólida no rim direito, submetido a nefrectomia radical que revelou tumor, cujo exame anatomopatológico permitiu o diagnóstico de carcinoma medular do rim. Os autores discutem aspectos dessa neoplasia, tais como freqüência, patogênese, apresentação clínica, histopatologia e evolução. Abstract in english We report the case of a 24-year-old patient who presented a left kidney tumor that was diagnosed as a medullary renal cell carcinoma. The following aspects of this neoplasia are discussed in this communication: frequency, pathogenesis, clinical presentation, histopathological findings, differential diagnosis and follow-up.

Salles, Paulo Guilherme de Oliveira; Miranda, Dairton; Seleiro, Arnaldo Jonas Pimentel; Castelo Branco, José Ribamar

2006-04-01

63

Echogenic rim of hepatic hemangioma on abdominal ultrasound  

International Nuclear Information System (INIS)

To investigate the association between the size of the hepatic hemangioma and the shape and thickness of the echogenic rim of hepatic hemangioma on abdominal ultrasound. We examined 47 cases (M:F=24:23, mean age 47.1) of hepatic hemangiomas with echogenic rim on abdominal ultrasound during the past 2 years. Radiologic findings were retrospectively reviewed in terms of completeness and thickness of echogenic rim. If echogenic rim showed even thickness, it was measured. But if not, the maximum and minimum thickness of the rim was measured. The association between the size of hemangioma and the completeness and thickness of the echogenic rim were analyzed statistically. Of the 47 cases, complete echogenic rim and incomplete echogenic rim were obtained in 29 (62%) and 18 (38%) cases, respectively. Twenty-two cases of hemangioma were less than 2 cm in diameter, and their distribution according to echogenic rim were as follows: complete echogenic rim (17/20, 91% mean thickness 2.2 cm) and uneven thickness with complete echogenic rim (3/20, 15%, range:2.0-6.1 mm). Twenty-five hemangiomas were larger than 2 cm in diameter and their distribution according to echogenic rim were as follows: complete echogenic rim (n=9, 34%), incomplete echogenic rim (n=16, 64%0,even thickness with complete echogenic rim (3/9, 33%, mean thickness 2.2 mm) and uneven thickness with complete echogenic rim (6/9,67%, range: 2.0-7.6 mm). In statistical analysis, hemangiomas more than 2 cm in diameter were more likely to have incomplete echogenic rim (p

2000-01-01

64

Late "rim sign"--a variant of an old sign.  

UK PubMed Central (United Kingdom)

Classically, the "rim sign" has been described throughout the hepatobiliary scan. The authors present a case of a late rim sign visualized at 25 minutes postinjection that proved to be acute upon chronic acalculous cholecystitis without gangrene.

Spieth ME; Seder JS; Stauffer JC; James RE; Ali F; Odom JA; Kimura RL

1994-03-01

65

Late "rim sign"--a variant of an old sign.  

Science.gov (United States)

Classically, the "rim sign" has been described throughout the hepatobiliary scan. The authors present a case of a late rim sign visualized at 25 minutes postinjection that proved to be acute upon chronic acalculous cholecystitis without gangrene. PMID:8033464

Spieth, M E; Seder, J S; Stauffer, J C; James, R E; Ali, F; Odom, J A; Kimura, R L

1994-03-01

66

Rim instability of bursting thin smectic films  

Science.gov (United States)

The rupture of thin smectic bubbles is studied by means of high speed video imaging. Bubbles of centimeter diameter and film thicknesses in the nanometer range are pierced, and the instabilities of the moving rim around the opening hole are described. Scaling laws describe the relation between film thickness and features of the filamentation process of the rim. A flapping motion of the retracting smectic film is assumed as the origin of the observed filamentation instability. A comparison with similar phenomena in soap bubbles is made. The present experiments extend studies on soap films [H. Lhuissier and E. Villermaux, Phys. Rev. Lett. 103, 054501 (2009)] to much thinner, uniform films of thermotropic liquid crystals.

Trittel, Torsten; John, Thomas; Tsuji, Kinko; Stannarius, Ralf

2013-05-01

67

Stress calculation model for thick rim flywheels  

Energy Technology Data Exchange (ETDEWEB)

The paper describes the model for the calculation of stress-strain distribution in composite material rotors. Composite rotors can be calculated with this model using the finite element method. The predicted data from these calculations has been compared with measured data. The influence of applying pretension to the composite during manufacturing, has been studied as well as the influence of temperature and shrinkage on the stress-strain distribution within the rotors. The low ultimate radial strain is the limiting design factor of thick rims. Furthermore this type of rotor suffers from the influence of shrinkage and temperature strains. These effects are difficult to handle and can lead to local overload of the material, resulting in cracks inside the rotors without applying rotational load. The results obtained from these investigations show that thick rim flywheels benefit from the application of pre-tension.

Burg, P. von [Swiss Federal Inst. of Tech., Zurich (Switzerland)

1995-11-01

68

Managing oil logistics around the Baltic Rim  

International Nuclear Information System (INIS)

Finland's Neste Group is a major player in the oil business in the Baltic area. Neste tankers and petroleum product logistics services comprehensively serve the region. Neste's main Baltic Rim terminal outside Finland is located at Muuga close to the Estonian capital, Tallinn. This will be joined by one in Riga in Latvia at the end of this year. A terminal for St. Petersburg is in the planning stage

1997-01-01

69

Radiological evaluation of cortical rim sign of the kidney  

Energy Technology Data Exchange (ETDEWEB)

The rim sign in renovascular compromise may be defined as a thin nephrographic rim outlining a kidney with an otherwise faint nephrogram. Renal infarction with gelform and blood clots was induced experimentally in 5 dogs and high dose IVP and CT were performed to evaluate renal cortical rim sign after renal infarction. One expired due to anesthetic technical failure, and one was embolized partially. So we could be obtain the result on 3 dogs. The results were as follows: 1. The high dose IVP films show cortical rim sign on 24 hrs and 72 hrs films in two dogs. The CT films show rim sign in 3 dogs. 2. The rim sign may be visualized, if the renal artery is occluded enough to drop perfusion pressure below the autoregulatory range. 3. The high dose IVP and early nephrogram phase are necessary for the rim sign.

Youn, Yea Seong; Yang, Seung Moon; Choi, Ki Chul [College of Medicine, Jeon Bug National University, Jeonju (Korea, Republic of)

1983-12-15

70

Radiological evaluation of cortical rim sign of the kidney  

International Nuclear Information System (INIS)

The rim sign in renovascular compromise may be defined as a thin nephrographic rim outlining a kidney with an otherwise faint nephrogram. Renal infarction with gelform and blood clots was induced experimentally in 5 dogs and high dose IVP and CT were performed to evaluate renal cortical rim sign after renal infarction. One expired due to anesthetic technical failure, and one was embolized partially. So we could be obtain the result on 3 dogs. The results were as follows: 1. The high dose IVP films show cortical rim sign on 24 hrs and 72 hrs films in two dogs. The CT films show rim sign in 3 dogs. 2. The rim sign may be visualized, if the renal artery is occluded enough to drop perfusion pressure below the autoregulatory range. 3. The high dose IVP and early nephrogram phase are necessary for the rim sign.

1983-01-01

71

Three-dimensional trabecular bone architecture of the lumbar spine in bone metastasis from prostate cancer: comparison with degenerative sclerosis  

Energy Technology Data Exchange (ETDEWEB)

Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. The objective of this study was to clarify the three-dimensional (3D) trabecular bone microstructure in bone metastasis from prostate cancer by comparison with normal and degenerative sclerotic bone lesions, using microcomputed tomography (micro-CT). A total of 32 cancellous bone samples were excised from the lumbar spine of six autopsy patients: 15 metastatic samples (one patient), eight degenerative sclerotic samples (four patients) and the rest from normal sites (three patients). The samples were serially scanned cross-sectionally by micro-CT with a pixel size of 23.20 {mu}m, slice thickness of 18.56 {mu}m, and image matrix of 512 x 512. Each image data set consisted of 250 consecutive slices. The volumes of interest (96 x 96 x 120 voxels) were defined in the original image sets and 3D indices of the trabecular microstructure were determined. The trabecular thickness (Tb.Th) in degenerative sclerotic lesions was significantly higher than that in normal sites, whereas no significant difference was observed in trabecular number (Tb.N). By contrast, in metastatic lesions, the Tb.N was significantly higher with increased bone volume fraction (BV/TV) than in normal sites, and no significant difference was found in Tb.Th. The characteristics of the trabecular surface in the metastatic samples showed concave structural elements with an increase in BV/TV, indicating osteolysis of the trabecular bone. In 3D reconstructed images, increased trabecular bone with an irregular surface was observed in samples from metastatic sites, which were uniformly sclerotic on soft X-ray radiographs. These results support, through 3D morphological features, the strong bone resorption effect in bone metastasis from prostate cancer. (orig.)

Tamada, Tsutomu; Sone, Teruki; Imai, Shigeki; Kajihara, Yasumasa; Fukunaga, Masao [Kawasaki Medical School, Department of Radiology, Kurashiki, Okayama (Japan); Jo, Yoshimasa [Kawasaki Medical School, Department of Urology, Kurashiki, Okayama (Japan)

2005-03-01

72

Three-dimensional trabecular bone architecture of the lumbar spine in bone metastasis from prostate cancer: comparison with degenerative sclerosis  

International Nuclear Information System (INIS)

Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. The objective of this study was to clarify the three-dimensional (3D) trabecular bone microstructure in bone metastasis from prostate cancer by comparison with normal and degenerative sclerotic bone lesions, using microcomputed tomography (micro-CT). A total of 32 cancellous bone samples were excised from the lumbar spine of six autopsy patients: 15 metastatic samples (one patient), eight degenerative sclerotic samples (four patients) and the rest from normal sites (three patients). The samples were serially scanned cross-sectionally by micro-CT with a pixel size of 23.20 ?m, slice thickness of 18.56 ?m, and image matrix of 512 x 512. Each image data set consisted of 250 consecutive slices. The volumes of interest (96 x 96 x 120 voxels) were defined in the original image sets and 3D indices of the trabecular microstructure were determined. The trabecular thickness (Tb.Th) in degenerative sclerotic lesions was significantly higher than that in normal sites, whereas no significant difference was observed in trabecular number (Tb.N). By contrast, in metastatic lesions, the Tb.N was significantly higher with increased bone volume fraction (BV/TV) than in normal sites, and no significant difference was found in Tb.Th. The characteristics of the trabecular surface in the metastatic samples showed concave structural elements with an increase in BV/TV, indicating osteolysis of the trabecular bone. In 3D reconstructed images, increased trabecular bone with an irregular surface was observed in samples from metastatic sites, which were uniformly sclerotic on soft X-ray radiographs. These results support, through 3D morphological features, the strong bone resorption effect in bone metastasis from prostate cancer. (orig.)

2005-01-01

73

Association Between the Proportion of Sclerotic Glomeruli and Serum Creatinine in Primary Focal Segmental Glomerulosclerosis  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To evaluate the possible correlation between the extent of sclerotic glomeruli and the level of serum creatinine and its clearance rate in patients with primary focal segmental glomerolusclerosis.Material and Method: In a cross-sectional study, 50 patients with biopsy-proven primary focal segmental glomerolusclerosis were recruited. The proportion of globally and segmentally sclerosed glomeruli was determined during the first histopathological examination of renal biopsy specimens. Correlations of these variables with on admission serum level of creatinine and its clearance rate were investigated.Results: Twenty-four males and 26 females with a mean age of 39.82±16.45 (range: 16-85) years were enrolled in the study. In a significant fashion, the proportions of segmental and global glomerulosclerosis were directly correlated with the serum level of creatinine and inversely with its clearance rate (r=-0.43 with p=0.002 and r=-0.45 with p=0.001, respectively).Conclusion: Apart from the degree of interstitial fibrosis, the serum level of creatinine and its clearance rate are well correlated with the proportions of both segmentally and globally sclerosed glomeruli in primary focal segmental glomerulosclerosis.

Ashraf FAKHRJOU; Ahad HASHEMPOUR; Sepideh SHADRAVAN; Rohollah Fadaei FOULADI

2012-01-01

74

Cellulitis related to bioabsorbable plate and screws in infraorbital rim fracture.  

Science.gov (United States)

An absorbable plating system is most commonly used to fix the bones in craniomaxillofacial surgery. Many studies focused on the advantages and clinical utility of absorbable plate and screws, but there are no reports on the complications related to these devices. From March 2004 to March 2009, 430 patients with facial bone fractures including infraorbital rim fractures underwent craniomaxillofacial surgery, in which rigid fixation was achieved with an absorbable plate and screws (Stryker, Freiburg, Germany). Five men with a delayed inflammatory reaction and infection at infraorbital rim fracture site were reviewed. Their mean age was 39 (range, 18-53 y), and all patients had maxillary sinusitis. The period from surgery to the onset of symptoms ranged from 3 to 10 weeks with a mean of 5 weeks. One patient was managed with oral antibiotics, but the other 4 patients required incisional drainage with the removal of the plate and screws because of abscess formation. The patients' symptom improved after removing the absorbable plate and screws and saline irrigation, and there was no recurrence of infection during the 12-month follow-up period. When fixing infraorbital fractures, particularly in patients with sinusitis, it is recommended to use short screws to prevent penetration of the maxillary sinus wall. In particular, one should pay attention and use shorter screws owing to the thinness of the medial infraorbital rim. PMID:21403541

Kwon, Ho; Kim, Sang-Wha; Jung, Sung-No; Sohn, Won-Il; Moon, Suk-Ho

2011-03-01

75

Cellulitis related to bioabsorbable plate and screws in infraorbital rim fracture.  

UK PubMed Central (United Kingdom)

An absorbable plating system is most commonly used to fix the bones in craniomaxillofacial surgery. Many studies focused on the advantages and clinical utility of absorbable plate and screws, but there are no reports on the complications related to these devices. From March 2004 to March 2009, 430 patients with facial bone fractures including infraorbital rim fractures underwent craniomaxillofacial surgery, in which rigid fixation was achieved with an absorbable plate and screws (Stryker, Freiburg, Germany). Five men with a delayed inflammatory reaction and infection at infraorbital rim fracture site were reviewed. Their mean age was 39 (range, 18-53 y), and all patients had maxillary sinusitis. The period from surgery to the onset of symptoms ranged from 3 to 10 weeks with a mean of 5 weeks. One patient was managed with oral antibiotics, but the other 4 patients required incisional drainage with the removal of the plate and screws because of abscess formation. The patients' symptom improved after removing the absorbable plate and screws and saline irrigation, and there was no recurrence of infection during the 12-month follow-up period. When fixing infraorbital fractures, particularly in patients with sinusitis, it is recommended to use short screws to prevent penetration of the maxillary sinus wall. In particular, one should pay attention and use shorter screws owing to the thinness of the medial infraorbital rim.

Kwon H; Kim SW; Jung SN; Sohn WI; Moon SH

2011-03-01

76

High burnup rim project. (IV) Threshold burnup of rim structure formation  

Energy Technology Data Exchange (ETDEWEB)

High burnup extension of LWR fuel is progressing to reduce the amount of total process flow in the nuclear fuel cycle and eventually to reduce the fuel cycle costs. As a result, the local burnup is now exceeding the anticipated range of the UO{sub 2} fuel that was investigated in the great time of the 1960's. A 'new phenomenon', a crystallographic re-structuring, is commonly observed at the rim area of high burnup fuel pellets in LWRs, and also in FBRs to some extent. The objectives of the High Burnup Rim Project (HBRP) are to identify the conditions of the rim structure formation as functions of burnup and temperature, and to investigate physical and chemical properties of fuels following this re-structuring. After the irradiation, the rods were transported to the Institute for Transuranium Elements (ITU), Karlsruhe for Post Irradiation Examinations (PIE). This report shows recent progress of PIE, and discusses threshold burnup and temperature of the rim structure formation (author) (ml)

Sonoda, T.; Matzke, Hj.; Kinoshita, M.

1999-05-15

77

The Pacific Rim and global natural gas  

International Nuclear Information System (INIS)

There is a growing interest in natural gas as a part of national or international strategies to moderate the environmental consequences of fuel use. Although the underutilized global gas resource justifies the interest, the future consumption of gas is likely to be constrained by the high capital costs of new transportation facilities to bring remote gas supplies into areas of growing energy demand. The Asian Pacific Rim countries include rapidly growing demand areas as well as significant reserves of gas. The region will continue to play a leading role in the evolution of a world trade in gas. Gas resources within the Asian Pacific region are adequate to serve the foreseeable demands, but historically the region has utilized liquefied natural gas (LNG) imports. Financial constraints upon the gas producing countries of the region and political instability in some of them will probably continue to require the importing of sustantial quantities of gas from the Middle East and possibly from Alaska and the former USSR as the resources indigenous to the region itself are developed more slowly than demand. The financial arrangements and contractual approaches that evolve to meet the needs of the Asia Pacific Rim will shape the future of world LNG markets. (Author)

1993-01-01

78

Measurement of wheel rim wear on railway wheels using radioisotopes  

International Nuclear Information System (INIS)

[en] A radioisotopic measuring method developed for studying the wear process of wheel rims of railway vehicles is described. The wear process may be monitored by the measurement of activity of a thin galvanic layer deposited onto the rim and labelled by iron 59. The high sensitivity of the method allows the determination of the wear rate distribution even within a few days. The results of measurements on three different rim profiles are analysed. (R.J.)

1979-01-01

79

Imaging appearance of bone tumors of the maxillofacial region  

Directory of Open Access Journals (Sweden)

Full Text Available This paper reviews the imaging appearance of benign and malignant bone tumors of the maxillofacial region. A benign bone tumor commonly appears as a well circumscribed lesion. The matrix of the tumor may be calcified or sclerotic. Malignancies often display aggressive characteristics such as cortical breakthrough, bone destruction, a permeative pattern and associated soft-tissue masses. Computed tomography scan is an excellent imaging modality for accurate localization of the lesion, characterization of the tumor matrix and detection of associated osseous changes such as bone remodeling, destruction or periosteal reaction. Magnetic resonance imaging is of limited value in the evaluation of maxillofacial bone tumors.

Ahmed Abdel Khalek Abdel Razek

2011-01-01

80

Rim for rotary inertial energy storage device and method  

Science.gov (United States)

The present invention is directed to an improved rim or a high-performance rotary inertial energy storage device (flywheel). The improved rim is fabricated from resin impregnated filamentary material which is circumferentially wound in a side-by-side relationship to form a plurality of discretely and sequentially formed concentric layers of filamentary material that are bound together in a resin matrix. The improved rim is provided by prestressing the filamentary material in each successive layer to a prescribed tension loading in accordance with a predetermined schedule during the winding thereof and then curing the resin in each layer prior to forming the next layer for providing a prestress distribution within the rim to effect a self-equilibrating compressive prestress within the windings which counterbalances the transverse or radial tensile stresses generated during rotation of the rim for inhibiting deleterious delamination problems.

Knight, Jr., Charles E. (Knoxville, TN); Pollard, Roy E. (Powell, TN)

1980-01-01

 
 
 
 
81

Pattern of onychomycosis--a RIMS study.  

Science.gov (United States)

Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts or non-dermatophytes moulds. In this study, 500 patients suspected of having onychomycosis reffered from the out patient department (OPD), Dermatology, Regional Institute of Medical Sciences (RIMS) Hospital Imphal Manipur during the period from January 2007 to December 2008 were processed in the Department of Microbiology RIMS. Nail clippings or scrapings depending on the variety of onychomycosis were collected with sterile blades under all aseptic measures. Specimens were put up for 10% KOH mount, fungal cultures on two sets of SDA (Sabouraud's dextrose agar) incorporated with antibiotics and lactophenol cotton blue preparation (LCB) from the cultures and examined microscopically. Slide cultures were also put up if necessary. Out of 500 samples processed, a total of 444 (88.8%) were positive for the various fungi. The positive fungi were dermatophytes 258 (58.1%), non-dermatophytes 139 (31.3%), yeasts and yeast-like 17 (3.8%) and mixed fungal isolates 30 (6.7%). Of the 230 males and 270 females studied,193 (83.9%) males and 251 (92.9%) females respectively were positive for various fungi causing onychomycosis. Maximum number of suspected cases were in the age group of 21-30 years. Among the dermatophytes, Trichophyton species (spp.) 250 (50%) was the commonest isolate followed by Epidermophyton spp. 8 (1.6%). Among the non-dermatophytes, Aspergillus spp. 70 (14%) was the commonest followed by Penicillium spp. 24 (4.8%), Acremonium spp. 9 (1.8%), Fusarium spp. 8 (1.6%), Curvularia spp. 7 (1.4%), Alternaria spp. 5 (1%), Scopulariopsis spp. 4 (0.8%), Cladosporium spp. 4 (0.8%), Nigrospora spp. 2 (0.4%), Mucor spp. 1 (0.2%), Paecilomyces spp. 1 (0.2%), Pseudallescheria spp. (0.2%), Rhizopus spp. 1 (0.2%), Verticillium spp. 1 (0.2%), Exophiala jeanselmei 1 (0.2%). Among the yeast and yeast-like i.e. Candida spp. 15, Geotrichum spp. 1, Rhodotorula spp. 1 were 17 (3.8%), mixed fungal isolates 30 (6.7%), respectively. Reports were given to the patient for follow up and treatment. Health awareness and suggestions were given for prevention and further spread of onychomycosis. PMID:23785867

Pukhrambam, Pratita Devi; Devi, Kh Ranjana; Singh, Ng Brajachand

2011-06-01

82

CT diagnosis of sacral bone tumors  

International Nuclear Information System (INIS)

[en] Objective: To evaluate the CT characteristics of sacral bone tumors. Methods: The CT characteristics of 28 cases with sacral bone tumors were retrospectively analyzed, including 13 cases metastasizes, 4 cases chordomas, 1 case chondrosarcoma, 1 case primitive neurotodemal tumors (PNET), 3 cases osteoblastomas, 1 case osteosarcoma, 2 cases neurilemmomas, 3 cases cysts (1 case of simple bone cyst and 2 cases of intracranial arachnoid cysts). Results: The CT characteristics of sacral bone tumors were as followings: different ranges and location of tumor, sacral bone destruction (lytic destruction for most malignant tumors and expansive for benign tumors), the remains of bone, soft tissue mass, calcification in tumor, sacral canal and sacral foramen obstruction. Benign tumors were often with sharp margin and sclerotic borders (except osteoblastomas), and the malignant tumors were often without clear verge and sclerotic borders. Except the cystic diseases, all the others were enhanced variously after contrast enhanced scanning. Conclusion: CT imaging can clearly display the location, ranges of tumor and the relation between tumor and surrounding tissues. Most sacral bone tumors can be correctly diagnosed in pre-operation according to their different CT characteristics. (authors)

2008-01-01

83

[Thirst and extensive bone lesions in a previously basically healthy woman].  

Science.gov (United States)

A previously quite healthy 65-year-old woman sought emergency hospital care due to fatigue, weight loss and sensation of thirst appearing over a couple of months. Further analysis revealed a process affecting the neurohypophysis and extensive lytic sclerotic bone lesions. Eventually a rare generalized underlying disease was unraveled: the diagnosis included both Langerhans cell histiocytosis and Erdheim-Chester disease. PMID:23342482

Laitinen, Kalevi; Lamminen, Antti; Anttila, Pekka; Lohman, Martina; Karjalainen-Lindsberg, Marja-Liisa

2012-01-01

84

Hepatobiliary rim sign: new implications for acute and complicated cholecystitis.  

UK PubMed Central (United Kingdom)

PURPOSE: The role of a 'rim sign' in increasing specificity for acute cholecystitis and sensitivity for complicated acute cholecystitis has been substantiated in many small retrospective studies. We sought to corroborate this correlation in a large population, as we have encountered doubt among surgeons about the emergent implications of this sign. METHODS: We performed a small pilot interobserver reliability test with five nuclear medicine physicians from outside institutions. A total of 2881 consecutive hepatobiliary scans performed over 12 years for evaluation of acute cholecystitis were retrospectively reviewed. Available pathological (reference standard) and surgical reports were reviewed for all cases of acute cholecystitis (on scintigraphy) with a rim sign and for an equivalent set without a rim sign. RESULTS: There was no statistically significant interobserver agreement on the presence of a rim sign. There was a 32.4% incidence of acute cholecystitis, based on scintigraphy, and a 10.1% incidence of rim signs. Of 63 pathologic specimens from rim-sign-positive cases, 19 (30.2%) showed acute cholecystitis and 44 (69.8%) showed chronic cholecystitis. Six (9.5%) cases were complicated. Among 55 pathologic specimens from the acute scintigraphy cases without a rim sign, 21 (38.2%) showed acute cholecystitis and 34 (61.8%) showed chronic cholecystitis. There were eight (14.5%) complicated cases. CONCLUSION: There was no interobserver reliability in the identification of a rim sign. There was almost no difference in the incidence of pathologically acute, chronic, or complicated acute cholecystitis among scintigraphically acute cases with or without a rim sign, approximately two-thirds to three-quarters of which were chronic on pathological evaluation.

Powell DK; Goldfarb RC; Ongseng F

2013-05-01

85

Denonvilliers' advancement flap in congenital alar rim defects correction  

Directory of Open Access Journals (Sweden)

Full Text Available Background. Alar rim defects are mostly acquired, resulting from burns, traumas or tumor excision. Sometimes they can accompany craniofacial clefts. However, isolated congenital alar defects are extremely rare. Case report. We presented two cases of congenital isolated alar cleft. The defect was closed by the use of an advancement flap, the technique described by Denonvilliers. We achieved both symmetry and appropriate thickness of the nostrils. Skin color and texture of the alar rim were excellent, with scars not excessively visible. Conclusion. Denonvilliers' z-plasty technique by using advancement flap provides both functionally and aesthetically satisfying outcome in patients with congenital alar rim defects.

Novakovi? Marijan; Barali? Ivanka; Stepi? Nenad; Rajovi? Milica; Stojiljkovi? Vladimir

2009-01-01

86

Varicocele treatment: A 2-centers comparison between non microsurgical open correction, laparoscopic approach and retrograde percutaneous sclerotization on 463 cases.  

Science.gov (United States)

Objectives: To determine whether there are differences in sperm parameters improvement after different varicocele correction techniques. To determine the role of age in sperm parameters improvement. Methods: 2 different European centers collected pre- and postoperative sperm parameters of patients undergoing varicocele correction. Among 463 evaluated patients, 367 were included. Patients were divided in procedure-related and age-related groups. Ivanissevich inguinal open surgical procedure (OS), lymphatic-sparing laparoscopic approach (LSL) and retrograde percutaneous transfemoral sclerotization (RPS) were performed. As outcome measurements sperm count (millions/mL, SC) and percentage of mobile sperms were analyzed. Univariate and multivariate regression between the defined groups; bivariate regression analysis between age and sperm count and motility. Results: Number of patients: OS 78; LSL 85; RPS 204. Mean age 30.2 (SD 6.83); postoperative SC increased from 18.2 to 30.1 (CI 95% 27.3-32.9; p Varicocele correction is confirmed useful in improving sperm parameters; sclerotization technique leads to a better sperm improvement compared to other studied procedures; improvement in seminal parameters is not affected by age of the patients treated. PMID:24085237

Ollandini, Giangiacomo; Liguori, Giovanni; Ziaran, Stanislav; Málek, Tomáš; Mazzon, Giorgio; De Concilio, Bernardino; Bucci, Stefano; Benvenuto, Sara; Belgrano, Emanuele; Trombetta, Carlo

2013-09-26

87

Rim region growth and its composition in reaction bonded boron carbide composites with core-rim structure  

International Nuclear Information System (INIS)

Aluminum was detected in reaction-bonded boron carbide that had been prepared by pressureless infiltration of boron carbide preforms with molten silicon in a graphite furnace under vacuum. The presence of Al2O3 in the heated zone, even though not in contact with the boron carbide preform, stands behind the presence of aluminium in the rim region that interconnects the initial boron carbide particles. The composition of the rim corresponds to the Bx(C,Si,Al)y quaternary carbide phase. The reaction of alumina with graphite and the formation of a gaseous aluminum suboxide (Al2O) accounts for the transfer of aluminum in the melt and, subsequently in the rim regions. The presence of Al increases the solubility of boron in liquid silicon, but with increasing aluminum content the activity of boron decreases. These features dominate the structural evolution of the rim-core in the presence of aluminum in the melt.

2009-06-01

88

Autosomal dominant type of endosteal hyperostosis with unusual manifestations of sclerosis of the jaw bones  

Energy Technology Data Exchange (ETDEWEB)

We report three cases of autosomal dominant type endosteal hyperostosis which occurred in one Japanese family. A new pattern of sclerotic changes in the jaw bones is evident. In all members of the family there was a symmetrical thickening of the diaphyseal cortices of the long bones. The affected bones were only minimally widened and the epiphyses and metaphyses were spared. Endosteal sclerosis of the neurocranium was present with loss of the diploe. The sclerotic changes included enlargement and mottled sclerosis of both the maxilla and mandible, with multiple embedded teeth and odontomas. The ramus of the mandible was spared. Severe sclerosis of the jaw bones was present only in a 28-year-old women. The 2-year-son showed only focal sclerosis in the mandible, and his grandmother had minimal changes in the skeleton.

Nakamura, Takashi; Yamada, Naoyuki; Nonaka, Ryosuke; Sasaki, Motomasa

1987-01-01

89

Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis  

Directory of Open Access Journals (Sweden)

Full Text Available Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Quinck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones.A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, diagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

V Silva; H Madrid; S Anticevic

2007-01-01

90

Varicocele treatment: A 2-centers comparison between non microsurgical open correction, laparoscopic approach and retrograde percutaneous sclerotization on 463 cases.  

UK PubMed Central (United Kingdom)

Objectives: To determine whether there are differences in sperm parameters improvement after different varicocele correction techniques. To determine the role of age in sperm parameters improvement. Methods: 2 different European centers collected pre- and postoperative sperm parameters of patients undergoing varicocele correction. Among 463 evaluated patients, 367 were included. Patients were divided in procedure-related and age-related groups. Ivanissevich inguinal open surgical procedure (OS), lymphatic-sparing laparoscopic approach (LSL) and retrograde percutaneous transfemoral sclerotization (RPS) were performed. As outcome measurements sperm count (millions/mL, SC) and percentage of mobile sperms were analyzed. Univariate and multivariate regression between the defined groups; bivariate regression analysis between age and sperm count and motility. Results: Number of patients: OS 78; LSL 85; RPS 204. Mean age 30.2 (SD 6.83); postoperative SC increased from 18.2 to 30.1 (CI 95% 27.3-32.9; p < 0,001); motility from 25.6 to 32.56% (30.9-34.2; p < 0.001). OS: SC varied from 16.9 to 18.2 (p < 0.001); sperm motility from 29% to 33% (p < 0.001). LSL: SC from 15.5 to 17.2 (p < 0.001); motility from 27 to 31% (p < 0.001). RPS: SC from 18.9 to 36.2 (p < 0.001); motility from 24% to 32% (p < 0.001). Univariate and multivariate analysis confirmed the significant difference of SC variation in RPS, compared to the other groups (p < 0.001). No significance between LSL and OS (p = 0.826). No significant differences regarding motility (p = 0.8). Conclusions: Varicocele correction is confirmed useful in improving sperm parameters; sclerotization technique leads to a better sperm improvement compared to other studied procedures; improvement in seminal parameters is not affected by age of the patients treated.

Ollandini G; Liguori G; Ziaran S; Málek T; Mazzon G; De Concilio B; Bucci S; Benvenuto S; Belgrano E; Trombetta C

2013-09-01

91

Effects of bone wax on rabbit cranial bone lesions.  

UK PubMed Central (United Kingdom)

The present study was designed to elucidate the reactions of cranial membranous bone to bone wax. In ten young rabbits, twenty parietal bone defects were created by drilling, the edges of which were partly extended using rongeur forceps to enable investigation of eventual thermal effects. Half of the marginal bone surrounding the lesions was covered by bone wax, the remainder serving as control. The animals were sacrificed 1 and 7 weeks after surgery, and block specimens prepared for light microscopy. Merely slight tissue reactions to the bone wax were discerned. Bony regeneration occurred mainly from the dura mater and the pericranium, but also from the bony rim. Reskeletalization was markedly impaired by the presence of bone wax. Heat generated by drilling caused reduced bone formation despite constant irrigation peroperatively. Clinical consequences are discussed.

Alberius P; Klinge B; Sjögren S

1987-04-01

92

The multiple faces of valosin-containing protein-associated diseases: inclusion body myopathy with Paget's disease of bone, frontotemporal dementia, and amyotrophic lateral sclerosis.  

UK PubMed Central (United Kingdom)

Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD) is a progressive, fatal genetic disorder with variable penetrance, predominantly affecting three main tissue types: muscle (IBM), bone (PDB), and brain (FTD). IBMPFD is caused by mutations in the ubiquitously expressed valosin-containing protein (VCP) gene, a member of the AAA-ATPase superfamily. The majority of individuals who develop IBM have progressive proximal muscle weakness. Muscle biopsies reveal rimmed vacuoles and inclusions that are ubiquitin- and TAR DNA binding protein-43 (TDP-43)-positive using immunohistochemistry. PDB, seen in half the individuals, is caused by overactive osteoclasts and is associated clinically with pain, elevated serum alkaline phosphatase, and X-ray findings of coarse trabeculation and sclerotic lesions. FTD diagnosed at a mean age of 55 years in a third of individuals is characterized clinically by comprehension deficits, dysnomia, dyscalculia, and social unawareness. Ubiquitin- and TDP-43-positive neuronal inclusions are also found in the brain. Genotype-phenotype correlations are difficult with marked intra-familial and inter-familial variations being seen. Varied phenotypes within families include frontotemporal dementia, amyotrophic lateral sclerosis, Parkinsonism, myotonia, cataracts, and anal incompetence, among others. Cellular and animal models indicate pathogenetic disturbances in IBMPFD tissues including altered protein degradation, autophagy pathway alterations, apoptosis, and mitochondrial dysfunction. Currently, mouse and drosophila models carrying VCP mutations provide insights into the human IBMPFD pathology and are useful as tools for preclinical studies and testing of therapeutic strategies. In this review, we will explore the pathogenesis and clinical phenotype of IBMPFD caused by VCP mutations.

Nalbandian A; Donkervoort S; Dec E; Badadani M; Katheria V; Rana P; Nguyen C; Mukherjee J; Caiozzo V; Martin B; Watts GD; Vesa J; Smith C; Kimonis VE

2011-11-01

93

The multiple faces of valosin-containing protein-associated diseases: inclusion body myopathy with Paget's disease of bone, frontotemporal dementia, and amyotrophic lateral sclerosis.  

Science.gov (United States)

Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD) is a progressive, fatal genetic disorder with variable penetrance, predominantly affecting three main tissue types: muscle (IBM), bone (PDB), and brain (FTD). IBMPFD is caused by mutations in the ubiquitously expressed valosin-containing protein (VCP) gene, a member of the AAA-ATPase superfamily. The majority of individuals who develop IBM have progressive proximal muscle weakness. Muscle biopsies reveal rimmed vacuoles and inclusions that are ubiquitin- and TAR DNA binding protein-43 (TDP-43)-positive using immunohistochemistry. PDB, seen in half the individuals, is caused by overactive osteoclasts and is associated clinically with pain, elevated serum alkaline phosphatase, and X-ray findings of coarse trabeculation and sclerotic lesions. FTD diagnosed at a mean age of 55 years in a third of individuals is characterized clinically by comprehension deficits, dysnomia, dyscalculia, and social unawareness. Ubiquitin- and TDP-43-positive neuronal inclusions are also found in the brain. Genotype-phenotype correlations are difficult with marked intra-familial and inter-familial variations being seen. Varied phenotypes within families include frontotemporal dementia, amyotrophic lateral sclerosis, Parkinsonism, myotonia, cataracts, and anal incompetence, among others. Cellular and animal models indicate pathogenetic disturbances in IBMPFD tissues including altered protein degradation, autophagy pathway alterations, apoptosis, and mitochondrial dysfunction. Currently, mouse and drosophila models carrying VCP mutations provide insights into the human IBMPFD pathology and are useful as tools for preclinical studies and testing of therapeutic strategies. In this review, we will explore the pathogenesis and clinical phenotype of IBMPFD caused by VCP mutations. PMID:21892620

Nalbandian, Angèle; Donkervoort, Sandra; Dec, Eric; Badadani, Mallikarjun; Katheria, Veeral; Rana, Prachi; Nguyen, Christopher; Mukherjee, Jogeshwar; Caiozzo, Vincent; Martin, Barbara; Watts, Giles D; Vesa, Jouni; Smith, Charles; Kimonis, Virginia E

2011-09-03

94

Histologia e ultraestrutura do rim e rim cefálico do pacu/ Histology and ultrastructure of kidney and cephalic kidney in Pacu  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopot (more) amicus, analisando os perfis celulares de cada órgão com o uso de microscopia de luz e microscopia eletrônica de transmissão. O resultado da análise macroscópica mostrou que a localização do rim e rim cefálico são as mesmas encontradas na maioria dos teleósteos. O rim apresentou uma forma em "H", onde a região média se expandia sobre a bexiga natatória. O rim cefálico se apresentou como uma dilatação na região cranial do rim, mostrando-se bem visível. Na microscopia eletrônica de transmissão também foram observadas similaridades ultraestruturais com outros teleósteos. Observando nossos resultados concluímos que histologicamente e ultraestruturalmente, os órgãos linfóides rim e rim cefálico de Piaractus mesopotamicus são similares aos de outros teleósteos. Abstract in english The Pacu, Piaractus mesopotamicus, is a teleostei of the Characidae family, intensively cultivated in Brazil due to its rusticity, fast growth and easy adaptation. Morphological knowledge of the body systems including the lymphoid organs is necessary to improve fish production and supply subsidies for the maintenance of stocks. This study aimed to describe morphologically kidney and head kidney of Piaractus mesopotamicus, analyzing the cellular profile of each organ with (more) the use of light microscopy and electronic transmission microscopy. The result of the macroscopic analysis showed that the localization of the kidney and head kidney is the same as found in the majority of the teleostei. The kidney presented a form in "H", where the medium region is expanded on the natatorium bladder. The head kidney presented a dilatation in the cranial region of the kidney. In the transmission electronic microscopy we found ultrastructural similarities with other teleostei fish. It can be concluded that the lymphoid organs (kidney and head kidney) of Piaractus mesopotamicus are histologically and ultra-structurally similar to the other teleostei.

Costa, Gerlane M.; Lima, Ana R.; Lima, Mendelson G. de; Kfoury Jr, José R

2012-05-01

95

Experimental study of THGEM detector with mini-rim  

CERN Multimedia

The gas gain and energy resolution of single and double THGEM detectors (5{\\times}5cm2 effective area) with mini-rims (rim is less than 10{\\mu}m) were studied. The maximum gain can reach 5{\\times}103 and 2{\\times}105 for single and double THGEM respectively, while the energy resolution of 5.9 keV X-ray varied from 18% to 28% for both single and double THGEM detectors of different hole sizes and thicknesses.All the experiments were investigated in mixture of noble gases(argon,neon) and small content of other gases(iso-butane,methane) at atmospheric pressure.

Zhang, Ai-Wu; Xie, Yu-Guang; Liu, Hong-Bang; An, Zheng-Hua; Wang, Zhi-Gang; Cai, Xiao; Sun, Xi-Lei; Shi, Feng; Fang, Jian; Xue, Zhen; Lu, Qi-Wen; Sun, Li-Jun; Ge, Yong-Shuai; Liu, Ying-Biao; Hu, Tao; Zhou, Li; Lu, Jun-Guang

2011-01-01

96

Lower-Rim Substituted Calixarenes and Their Applications  

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Full Text Available This review discusses in detail “calixarenes” since their discovery as by-products of the phenol formaldehyde bakelites till the present scenario wherein calixarene has assumed a new dimension in the field of supramolecular chemistry. Extensive literature exists for calixarenes; but herein we have tried to concentrate on the different lower-rim modified calixarenes with their potential applications. An attempt has also been made to critically evaluate the synthesis procedures for different lower-rim substituted calixarenes.

Princy Jose; Shobana Menon

2007-01-01

97

MRI evaluation of primary bone tumors  

Energy Technology Data Exchange (ETDEWEB)

The magnetic resonance imaging (MRI) characteristics of primary malignant bone tumors are evaluated in determination of the surgical margin. Fifteen patients were examined with Toshiba MR imager (0.22-T resistive magnet). Eight patients had osteosarcoma, three had chondrosarcoma, three had giant cell tumor of bone, and one had angiosarcoma of bone. All patients had CT scans available for comparison. The extra-and intra-osseous extension of the lesion were separately studied. MRI was considerably superior to CT in all cases with osteolytic lesion. MRI was, especially, superior to CT for demonstrating the extent of tumor in marrow. Moreover, MRI was extremely useful for the assessment in the lesion of thoracic wall. CT was only superior to MRI for depicting the extraosseous extent in sclerotic type of osteosarcoma. Above all, MRI was the imaging method of choice in determination of the surgical margin for malignant bone tumors. (author).

Yonemura, Kensuke; Tsuchiya, Tatsuaki; Sagara, Takaaki; Takagi, Katsumasa; Nishida, Kimiaki; Nakamura, Eiichi (Kumamoto Univ. (Japan). School of Medicine)

1989-10-01

98

MRI evaluation of primary bone tumors  

International Nuclear Information System (INIS)

[en] The magnetic resonance imaging (MRI) characteristics of primary malignant bone tumors are evaluated in determination of the surgical margin. Fifteen patients were examined with Toshiba MR imager (0.22-T resistive magnet). Eight patients had osteosarcoma, three had chondrosarcoma, three had giant cell tumor of bone, and one had angiosarcoma of bone. All patients had CT scans available for comparison. The extra-and intra-osseous extension of the lesion were separately studied. MRI was considerably superior to CT in all cases with osteolytic lesion. MRI was, especially, superior to CT for demonstrating the extent of tumor in marrow. Moreover, MRI was extremely useful for the assessment in the lesion of thoracic wall. CT was only superior to MRI for depicting the extraosseous extent in sclerotic type of osteosarcoma. Above all, MRI was the imaging method of choice in determination of the surgical margin for malignant bone tumors. (author)

1989-01-01

99

Posterior glenoid rim deficiency in recurrent (atraumatic) posterior shoulder instability  

Energy Technology Data Exchange (ETDEWEB)

Objective. To assess the shape of the posterior glenoid rim in patients with recurrent (atraumatic) posterior instability.Design and patients. CT examinations of 15 shoulders with recurrent (atraumatic) posterior instability were reviewed in masked fashion with regard to abnormalities of the glenoid shape, specifically of its posterior rim. The glenoid version was also assessed. The findings were compared with the findings in 15 shoulders with recurrent anterior shoulder instability and 15 shoulders without instability. For all patients, surgical correlation was available.Results. Fourteen of the 15 (93%) shoulders with recurrent (atraumatic) posterior shoulder instability had a deficiency of the posteroinferior glenoid rim. In patients with recurrent anterior instability or stable shoulders such deficiencies were less common (60% and 73%, respectively). The craniocaudal length of the deficiencies was largest in patients with posterior instability. When a posteroinferior deficiency with a craniocaudal length of 12 mm or more was defined as abnormal, sensitivity and specificity for diagnosing recurrent (atraumatic) posterior instability were 86.7% and 83.3%, respectively. There was a statistically significant difference in glenoid version between shoulders with posterior instability and stable shoulders (P=0.01).Conclusion. Recurrent (atraumatic) posterior shoulder instability should be considered in patients with a bony deficiency of the posteroinferior glenoid rim with a craniocaudal length of more than 12 mm. (orig.)

Weishaupt, D.; Zanetti, M.; Hodler, J. [Dept. of Radiology, University Hospital Balgrist, Zurich (Switzerland); Nyffeler, R.W.; Gerber, C. [Dept. of Orthopedic Surgery, University Hospital Balgrist, Zurich (Switzerland)

2000-04-01

100

Posterior glenoid rim deficiency in recurrent (atraumatic) posterior shoulder instability  

International Nuclear Information System (INIS)

Objective. To assess the shape of the posterior glenoid rim in patients with recurrent (atraumatic) posterior instability.Design and patients. CT examinations of 15 shoulders with recurrent (atraumatic) posterior instability were reviewed in masked fashion with regard to abnormalities of the glenoid shape, specifically of its posterior rim. The glenoid version was also assessed. The findings were compared with the findings in 15 shoulders with recurrent anterior shoulder instability and 15 shoulders without instability. For all patients, surgical correlation was available.Results. Fourteen of the 15 (93%) shoulders with recurrent (atraumatic) posterior shoulder instability had a deficiency of the posteroinferior glenoid rim. In patients with recurrent anterior instability or stable shoulders such deficiencies were less common (60% and 73%, respectively). The craniocaudal length of the deficiencies was largest in patients with posterior instability. When a posteroinferior deficiency with a craniocaudal length of 12 mm or more was defined as abnormal, sensitivity and specificity for diagnosing recurrent (atraumatic) posterior instability were 86.7% and 83.3%, respectively. There was a statistically significant difference in glenoid version between shoulders with posterior instability and stable shoulders (P=0.01).Conclusion. Recurrent (atraumatic) posterior shoulder instability should be considered in patients with a bony deficiency of the posteroinferior glenoid rim with a craniocaudal length of more than 12 mm. (orig.)

2000-01-01

 
 
 
 
101

Threshold burnup for recrystallization and model for rim porosity in the high burnup UO2 fuel  

International Nuclear Information System (INIS)

[en] Applicability of the threshold burnup for rim formation was investigated as a function of temperature by Rest's model. The threshold burnup was the lowest in the intermediate temperature region, while on the other temperature regions the threshold burnup is higher. The rim porosity was predicted by the van der Waals equation based of the rim pore radius of 0.75?m and the overpressurization model on rim pores. The calculated centerline temperature is in good agreement with the measured temperature. However, more efforts seem to be necessary for the mechanistic model of the rim effect including rim growth with the fuel burnup

1998-01-01

102

Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea/ Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Quinck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente (more) no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones. Abstract in english A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, diagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

Silva, V; Madrid, H; Anticevic, S

2007-01-01

103

Esclerosis inflamatoria orbitaria y síndrome de fibrosis multifocal/ Sclerotic inflammation of the orbit and multifocal fibrosclerosis syndrome  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Caso clínico: Mujer de 52 años que consulta en nuestro Servicio por proptosis bilateral. La aparición de sintomatología aguda digestiva durante el ingreso para el estudio de la proptosis, condujo al diagnóstico de un cuadro de fibroesclerosis multifocal, con afectación simultánea de los tejidos orbitarios, grasa mesentérica y tronco de encéfalo. Discusión: El pseudotumor esclerosante orbitario es una rara entidad clinicopatológica, cuyas características en la (more) clínica y en las pruebas de imagen pueden ser similares a las del pseudotumor inflamatorio idiopático. El diagnóstico diferencial es importante porque ambos difieren tanto en su tratamiento como en su pronóstico. Abstract in english Clinical case: A fifty-two-year-old woman consulted our department because of a bilateral proptosis. The appearance of acute symptoms suggestive of a digestive disorder during her admission to hospital for the study of the proptosis, led to a diagnosis of multifocal fibrosclerosis with simultaneous affliction of orbital tissue, mesenteric fat and the brain stem. Discussion: Idiopathic Sclerotic Inflammation of the orbit is a rare pathological entity, with similar clinical (more) and radiological characteristics to orbital pseudo-tumour. The differential diagnosis is important because both these conditions differ in treatment and prognosis.

Mataix, B.; López-Navarrete, E.; López-Domínguez, M.; Ángeles, R.

2008-04-01

104

Esclerosis inflamatoria orbitaria y síndrome de fibrosis multifocal Sclerotic inflammation of the orbit and multifocal fibrosclerosis syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available Caso clínico: Mujer de 52 años que consulta en nuestro Servicio por proptosis bilateral. La aparición de sintomatología aguda digestiva durante el ingreso para el estudio de la proptosis, condujo al diagnóstico de un cuadro de fibroesclerosis multifocal, con afectación simultánea de los tejidos orbitarios, grasa mesentérica y tronco de encéfalo. Discusión: El pseudotumor esclerosante orbitario es una rara entidad clinicopatológica, cuyas características en la clínica y en las pruebas de imagen pueden ser similares a las del pseudotumor inflamatorio idiopático. El diagnóstico diferencial es importante porque ambos difieren tanto en su tratamiento como en su pronóstico.Clinical case: A fifty-two-year-old woman consulted our department because of a bilateral proptosis. The appearance of acute symptoms suggestive of a digestive disorder during her admission to hospital for the study of the proptosis, led to a diagnosis of multifocal fibrosclerosis with simultaneous affliction of orbital tissue, mesenteric fat and the brain stem. Discussion: Idiopathic Sclerotic Inflammation of the orbit is a rare pathological entity, with similar clinical and radiological characteristics to orbital pseudo-tumour. The differential diagnosis is important because both these conditions differ in treatment and prognosis.

B. Mataix; E. López-Navarrete; M. López-Domínguez; R. Ángeles

2008-01-01

105

Rim region growth and its composition in reaction bonded boron carbide composites with core-rim structure  

Energy Technology Data Exchange (ETDEWEB)

Aluminum was detected in reaction-bonded boron carbide that had been prepared by pressureless infiltration of boron carbide preforms with molten silicon in a graphite furnace under vacuum. The presence of Al{sub 2}O{sub 3} in the heated zone, even though not in contact with the boron carbide preform, stands behind the presence of aluminium in the rim region that interconnects the initial boron carbide particles. The composition of the rim corresponds to the B{sub x}(C,Si,Al){sub y} quaternary carbide phase. The reaction of alumina with graphite and the formation of a gaseous aluminum suboxide (Al{sub 2}O) accounts for the transfer of aluminum in the melt and, subsequently in the rim regions. The presence of Al increases the solubility of boron in liquid silicon, but with increasing aluminum content the activity of boron decreases. These features dominate the structural evolution of the rim-core in the presence of aluminum in the melt.

Hayun, S; Weizmann, A; Dilman, H; Dariel, M P; Frage, N [Department of Materials Engineering, Ben-Gurion University of the Negev, P. O. Box 653, Beer-Sheva 84105 (Israel)], E-mail: hayuns@bgu.ac.il

2009-06-01

106

16 CFR Figure 8 to Part 1512 - Reflectorized Bicycle Wheel Rim Abrasion Test Device  

Science.gov (United States)

...2009-01-01 false Reflectorized Bicycle Wheel Rim Abrasion Test Device 8 ...SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR BICYCLES Pt. 1512, Fig. 8 Figure 8 to Part 1512âReflectorized Bicycle Wheel Rim Abrasion Test Device...

2009-01-01

107

Hemangioendotelioma Hepático Infantil e Rim Displásico Multiquístico: uma nova associação?  

Directory of Open Access Journals (Sweden)

Full Text Available O hemangioendotelioma hepático infantil tem uma incidência que é a terceira entre os tumores hepáticos da criança e é o tumor benigno hepático vascular mais frequente na infância. Apresentamos o caso clínico de uma criança com o diagnóstico de hemangioendotelioma hepático associado a rim displásico multiquístico transitório. O diagnóstico de rim multiquístico foi confirmado por ecografia no período pré e pós natal. Numa ecografia realizada aos 5 meses detectaram-se lesões hepáticas sugestivas de hemangioendotelioma. Realizou ressonância magnética aos 8 meses que não mostrou o rim direito. A biópsia hepática confirmou o diagnóstico de hemangioendotelioma infantil tipo1. Em ecografias seriadas verificou-se redução das lesões hepáticas que desapareceram aos 19 meses. Esta associação de hemangioendotelioma hepático e rim multiquístico não se encontra descrita, embora sejam conhecidas associações com agenesia renal.Infantile hemangioendothelioma has an incidence that is the third most common between hepatic tumours in children and the most common benign vascular tumour of the liver in infancy. In this paper we report a clinical case of a child with hepatic hemangioendothelioma associated with a transitory multicystic dysplastic kidney. The multicystic disorder was evident pre and post natally. At 5 months an ultrasonography imaging showed multiple hepatic lesions suggestive of hemangioendothelioma. At 8 months a magnetic resonance imaging did not show the right kidney. Hepatic biopsy confirmed the diagnosis of infantile hemangioendothelioma. On ultrasonographies performed during follow up focal hepatic lesions reduced and disappeared by 19 months. This association has not been reported although cases associated with unilateral renal agenesis are known.

M. Carneiro de Moura; P. Sampaio Nunes; H. Flores; P. Sande Lemos

2009-01-01

108

Hemangioendotelioma Hepático Infantil e Rim Displásico Multiquístico: uma nova associação?  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O hemangioendotelioma hepático infantil tem uma incidência que é a terceira entre os tumores hepáticos da criança e é o tumor benigno hepático vascular mais frequente na infância. Apresentamos o caso clínico de uma criança com o diagnóstico de hemangioendotelioma hepático associado a rim displásico multiquístico transitório. O diagnóstico de rim multiquístico foi confirmado por ecografia no período pré e pós natal. Numa ecografia realizada aos 5 meses (more) detectaram-se lesões hepáticas sugestivas de hemangioendotelioma. Realizou ressonância magnética aos 8 meses que não mostrou o rim direito. A biópsia hepática confirmou o diagnóstico de hemangioendotelioma infantil tipo1. Em ecografias seriadas verificou-se redução das lesões hepáticas que desapareceram aos 19 meses. Esta associação de hemangioendotelioma hepático e rim multiquístico não se encontra descrita, embora sejam conhecidas associações com agenesia renal. Abstract in english Infantile hemangioendothelioma has an incidence that is the third most common between hepatic tumours in children and the most common benign vascular tumour of the liver in infancy. In this paper we report a clinical case of a child with hepatic hemangioendothelioma associated with a transitory multicystic dysplastic kidney. The multicystic disorder was evident pre and post natally. At 5 months an ultrasonography imaging showed multiple hepatic lesions suggestive of heman (more) gioendothelioma. At 8 months a magnetic resonance imaging did not show the right kidney. Hepatic biopsy confirmed the diagnosis of infantile hemangioendothelioma. On ultrasonographies performed during follow up focal hepatic lesions reduced and disappeared by 19 months. This association has not been reported although cases associated with unilateral renal agenesis are known.

Moura, M. Carneiro de; Nunes, P. Sampaio; Flores, H.; Lemos, P. Sande

2009-03-01

109

Modelo de tumor experimental em rim de ratos  

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Full Text Available O carcinossarcoma 256 de Walker tem despertado o interesse de muitos pesquisadores como modelo experimental para estudo da biologia tumoral. OBJETIVO: estabelecer um modelo de tumor renal que possa ser usado para estudar in vivo e in vitro, as alterações impostas pelas neoplasias. MÉTODOS: utilizados vinte ratos Wistar, machos, adultos, pesando entre 250-300 g, oriundos do Laboratório de Cirurgia Experimental da Universidade Federal do Ceará. Sob anestesia inalatória procedia-se uma pequena incisão supraumbilical, e com manobra delicada fazia-se a exposição do rim direito. Neste órgão eram inoculadas 3x10(5) células tumorais viáveis. Os animais então eram mantidos em gaiolas individuais com as mesmas condições ambientais e com água e dieta ad libitum. RESULTADOS: o Carcinossarcoma 256 de Walker, implantado no parênquima do rim direito de ratos Wistar apresentou índice de pega de 100%, e crescimento rápido, invadiu por contiguidade as estruturas vizinhas, porém sem apresentar metástases, no entanto, levando os animais a óbito no curso médio de 14 dias. CONCLUSÃO: o modelo de implante de tumor de Walker no parênquima do rim direito de ratos Wistar é eficiente, tem reprodutibilidade, apresentando um índice de pega de 100%, e permitindo seu uso em linhas de pesquisa.

Silva Lúcio Flávio Gonzaga; Soares Felipe dos Santos Dias; Anselmo José Nilson Nunes; Fé Daniel Mota Moura; Cavalcante João Luiz Barbosa Gurgel; Moraes Manoel Odorico de; Vasconcelos Paulo Roberto Leitão de

2002-01-01

110

Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS) and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI), the 2-step self-etch Adper SE Bond (3MESPE) and the 35% phosphoric acid (3MESPE) from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE) were applied on the bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm 2 ) and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material) was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment), according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05). Results: The duplication of the conditioning time favored only the GO adhesive (p<0.05). Both application methods significantly increased the tubule area opening (p<0.05) compared to the controls. Conclusions: The efficacy of duplicating the conditioning time was only effective for the 1-step self-etch adhesive system tested.

Alexandra Patricia Mena-Serrano; Eugenio Jose Garcia; Miguel Muñoz Perez; Gislaine Cristine Martins; Rosa Helena Miranda Grande; Alessandro Dourado Loguercio; Alessandra Reis

2013-01-01

111

Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS) and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI), the 2-step self-etch Adper SE Bond (3MESPE) and the 35% phosphoric acid (3MESPE) from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE) were applied on th (more) e bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm 2 ) and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material) was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment), according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05). Results: The duplication of the conditioning time favored only the GO adhesive (p<0.05). Both application methods significantly increased the tubule area opening (p<0.05) compared to the controls. Conclusions: The efficacy of duplicating the conditioning time was only effective for the 1-step self-etch adhesive system tested.

Mena-Serrano, Alexandra Patricia; Garcia, Eugenio Jose; Perez, Miguel Muñoz; Martins, Gislaine Cristine; Grande, Rosa Helena Miranda; Loguercio, Alessandro Dourado; Reis, Alessandra

2013-04-01

112

Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To evaluate the effect of application time on the resin-dentin bond strength (µTBS) and etching pattern of adhesive systems applied on sclerotic dentine. MATERIAL AND METHODS: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI), the 2-step self-etch Adper SE Bond (3MESPE) and the 35% phosphoric acid (3MESPE) from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE) were applied on the bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm²) and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material) was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment), according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05). RESULTS: The duplication of the conditioning time favored only the GO adhesive (p<0.05). Both application methods significantly increased the tubule area opening (p<0.05) compared to the controls. CONCLUSIONS: The efficacy of duplicating the conditioning time was only effective for the 1-step self-etch adhesive system tested.

Mena-Serrano AP; Garcia EJ; Perez MM; Martins GC; Grande RH; Loguercio AD; Reis A

2013-03-01

113

Genome sequences of two freshwater betaproteobacterial isolates, Limnohabitans species strains Rim28 and Rim47, indicate their capabilities as both photoautotrophs and ammonia oxidizers.  

UK PubMed Central (United Kingdom)

Betaproteobacterial genus Limnohabitans represents an important part of freshwater bacterioplankton. Here, we report genome sequences of two Limnohabitans isolates, Rim28 and Rim47. They contain a complete photosynthesis gene cluster, RuBisCO, CO dehydrogenase, ammonia monooxygenase, and sulfur-oxidizing genes, which indicates a great metabolic versatility of the Limnohabitans species.

Zeng Y; Kasalický V; Šimek K; Koblížeka M

2012-11-01

114

The natural history of disappearing bone tumours and tumour-like conditions  

Energy Technology Data Exchange (ETDEWEB)

We describe 27 cases of bone tumours or tumour-like lesions where there was spontaneous regression. The follow-up period was 2.8-16.7 years (average, 7.0 years). Fourteen of these cases were no longer visible on plain radiographs. Histological diagnosis included exostosis, eosinophilic granuloma, fibrous dysplasia, fibrous cortical defect, non-ossifying fibroma, osteoid osteoma and bone island. Most cases began to reduce in adolescence or earlier, although sclerotic type lesions showed their regression in older patients. All lesions thought to be eosinophilic granuloma began to regress after periods of less than 3 months, while the duration of the other lesions showed wide variation (1-74 months). As resolution of the lesions took between 2 and 79 months (mean, 25.0 {+-} 20.3 months) we consider that the most likely mechanism was recovery of normal skeletal growth control. In exostosis with fracture, alteration of vascular supply may contribute to growth arrest, but not to subsequent remodelling stage. In inflammatory-related lesions such as eosinophilic granuloma, cessation of inflammation may be the mechanism of growth arrest, whilst temporary inflammation may stimulate osteogenic cells engaged in remodeling. In the sclerotic type, growth arrest is a less probable mechanism. Necrosis within the tumour and/or local changes in hormonal control, plus remodelling of the sclerotic area takes longer. Knowledge of the potential for spontaneous resolution may help in management of these tumour and tumour-like lesions of bone. Yanagawa, T. et al. (2001)

Yanagawa, Takashi; Watanabe, Hideomi; Shinozaki, Tetsuya; Ahmed, Adel Refaat; Shirakura, Kenji; Takagishi, Kenji

2001-11-01

115

Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy.  

Science.gov (United States)

Growing evidence suggests that human immunodeficiency virus (HIV)-1 infection of podocytes plays a central role in the glomerular disease of HIV-associated nephropathy (HIVAN). As an approach to identify host genes involved in the pathogenesis of the sclerotic glomerular lesion in HIVAN, representational difference analysis of cDNA was used to identify differentially expressed genes in HIV-1 transgenic and nontransgenic podocytes. We isolated a novel member of the small leucine-rich repeat (SLR) protein family, podocan, that is expressed at high levels in the HIV-1 transgenic podocytes. In normal embryonic kidney, a 3.2-kb podocan transcript was detected at low levels, and expression increased dramatically within 24 h following birth. Expression of a 2.3-kb transcript became evident after birth and gradually increased to 50% of the total podocan RNA in the mature kidney. Phylogenetically, podocan represents a new class in the SLR protein gene family, an expanding protein family sharing homology with the small leucine-rich repeat proteoglycans. The 3.2-kb transcript encodes a predicted 611-amino acid secretory protein with 20 leucine-rich repeats, a unique N-terminal cysteine-rich cluster pattern and a highly acidic C-terminal domain. In situ hybridization of normal kidney revealed podocan mRNA expression in podocytes and likely vascular endothelial cells within the glomerulus. The immunohistochemical staining pattern of podocan protein in normal kidney glomeruli was consistent with that of the glomerular basement membrane, and staining was markedly increased in sclerotic glomerular lesions in the transgenic HIVAN model. Thus, podocan defines a new class within the SLR protein family and is a previously unrecognized component of the sclerotic glomerular lesion that develops in the course of experimental HIVAN. PMID:12796502

Ross, Michael D; Bruggeman, Leslie A; Hanss, Basil; Sunamoto, Masaaki; Marras, Daniele; Klotman, Mary E; Klotman, Paul E

2003-06-08

116

Orthodontic movement of impacted cuspid in fibrodysplastic bone: a case report.  

UK PubMed Central (United Kingdom)

A case of orthodontic replacement of impacted cuspid in fibrodysplastic maxillary bone in a 12-year-old girl is reported. Fibrodysplastic bone is classically described as a fibrous bone without osteoblastic rimming. It is well known that orthodontic forces lead to tooth movement through proliferation and increased activity of bone cells (osteoblasts and osteoclasts). The reported case clinically support the latest histological studies suggesting that in fibrodisplastic bone osteoblasts are present but altered in shape and therefore difficult to recognize in sections.

Colella G; Itro A; Perillo L; Cannavale R

2010-01-01

117

RIMS diagnostics for laser desorption/laser ablation  

Energy Technology Data Exchange (ETDEWEB)

Laser desorption mass spectrometry is a useful method for interrogating materials and events at or near surfaces. Laser desorption/ablation combined with Resonance Ionization Mass Spectrometry (RIMS) provides a powerful tool to obtain information on chemical composition and speciation and, in some cases, internal and translational energy distributions. The application of this technique to the interrogation of materials and interfaces is discussed for several systems, including the analysis of conventional analytical samples, and the study of optical damage events. 8 refs., 2 figs., 1 tab.

Apel, E.C.; Nogar, N.S.; Miller, C.M.; Estler, R.C.

1986-01-01

118

Amphibole reaction rim textures and mineralogy from the 2006 eruption of Augustine Volcano, Alaska: Nature vs. experiment  

Science.gov (United States)

Augustine Volcano forms a small island located in Alaska's Cook Inlet, approximately 180 miles southwest of Anchorage. The 2006 eruption began January 11, 2006, and evolved from an initial phase of explosive activity, through continuous and effusive phases, ending approximately mid-March 2006. We present data on the textural and mineralogical make-up of amphibole reaction rims from 2006 andesites from Augustine. Naturally formed reaction rims are compared to rims formed through decompression and heating experiments. Amphiboles make up less than 1 modal % of most samples. However, variations in composition and texture help to explain pre-and syn-eruptive magma histories. The Augustine 2006 amphiboles contain a mixture of rimmed and unrimmed grains. In order of decreasing abundance (by tally), the dominant phases in reaction rims are orthopyroxene, oxides, plagioclase, and clinopyroxene. Most amphibole reaction rims are between 1- 40 microns in thickness. Thicker rims (> 40 microns) were primarily erupted in the later effusive phase of the eruption. In general, the thickest reactions rims (> 60 microns average thickness) contain coarser individual reaction rim grains (with feret diameters of 15-50 microns). Reaction rims with average thickness of less than 60 microns tend to contain finer reaction rim grains (with feret diameters of 10 microns or less). Some reactions rims show a coarsening of rim grains across the rim, from the amphibole boundary to the glass boundary. Preliminary results show no systematic changes in the aspect ratios of reaction rim grains, either across the rim, or between the different rims. Some rims show a decrease in the An content of plagioclase across the rim, from the amphibole boundary to the glass boundary. Reaction rim textures and mineralogy are complex and suggest that multiple forcing factors (including heating and decompression) were responsible for their formation. This study will compare these natural reaction rims to those formed in experiments.

Henton, S.; Larsen, J. F.; Coombs, M. L.

2011-12-01

119

A new flea, Ectinorus (Ectinorus) insignis n. sp. (Siphonaptera, Rhopalopsyllidae, Parapsyllinae), with notes on the subgenus Ectinorus in Chile and comments on unciform sclerotization in the superfamily Malacopsylloidea.  

UK PubMed Central (United Kingdom)

A list is provided for the species of Ectinorus sensu stricto from Chile. Ectinorus (Ectinorus) insignis n. sp. is described from Chile: this species is characterized by the male genitalia. In the subgenus Ectinorus, the authors report the presence in Chile of E. pilosus Beaucournu & Carmen Castro, 2002 described from Argentina and E. simonsi (Rothschild, 1904) described from Bolivia but also known from Peru. A female neallotype is designated for E. ineptus Johnson, 1957. "Unciform sclerotization" is noted and illustrated for the first time, in all Malacopsylloidea, and a list is given for all studied species.

Beaucournu JC; Belaz S; Muñoz-Léal S; González-Acuña D

2013-01-01

120

Role of RIM1? in short- and long-term synaptic plasticity at cerebellar parallel fibres.  

UK PubMed Central (United Kingdom)

The presynaptic terminals of synaptic connections are composed of a complex network of interacting proteins that collectively ensure proper synaptic transmission and plasticity characteristics. The key components of this network are the members of the RIM protein family. Here we show that RIM1? can influence short-term plasticity at cerebellar parallel-fibre synapses. We demonstrate that the loss of a single RIM isoform, RIM1?, leads to reduced calcium influx in cerebellar granule cell terminals, decreased release probability and consequently an enhanced short-term facilitation. In contrast, we find that presynaptic long-term plasticity is fully intact in the absence of RIM1?, arguing against its necessary role in the expression of this important process. Our data argue for a universal role of RIM1? in setting release probability via interaction with voltage-dependent calcium channels at different connections instead of synapse-specific functions.

Kintscher M; Wozny C; Johenning FW; Schmitz D; Breustedt J

2013-09-01

 
 
 
 
121

Surgical correction of retracted nostril rim with auricular composite grafts and anchoring suspention.  

UK PubMed Central (United Kingdom)

Among concerned nasal appearances, a deformity with supero-lateral displacement of the nostril rim, called retracted nostril rim or elevated nostril rim is commonly seen and is considered one of the most difficult types of cases to treat aesthetically. A new surgical method for treating retracted nostril rim was performed in 10 patients, using the combination of auricular composite graft, internal fixation with a retainer, and external continuing suspension with anchoring sutures. The procedure was successful in maintaining the grafted cartilage in the ideal position and in avoiding recurrence of retraction or elevation of the constructed alar rim. The presented method merits consideration as a standard operative approach for correction of retracted nostril rim.

Hirohi T; Yoshimura K

2003-09-01

122

Analysis of the energy capacity of rim-spoke composite flywheels  

Energy Technology Data Exchange (ETDEWEB)

The rim-spoke flywheel consisting of a rim, connected to the hub by spokes encompassing the rim periphery, is one of the most promising types of energy accumulators. For the rational design of rim-spoke flywheels, the authors investigate the dependence of their mass energy capacity and their volume energy capacity; the limit speed on the geometric parameters of the flywheel and the properties of the composites used in making the rim and the spokes are also examined. It is shown through various programs, worked out for analyzing the energy capacity of rim-spoke flywheels, that they can substantially facilitate the designing of such flywheels according to specified requirements that their operational characteristics have to meet.

Moorlat, P.A.; Portnov, G.G.

1986-03-01

123

Surgical correction of retracted nostril rim with auricular composite grafts and anchoring suspention.  

Science.gov (United States)

Among concerned nasal appearances, a deformity with supero-lateral displacement of the nostril rim, called retracted nostril rim or elevated nostril rim is commonly seen and is considered one of the most difficult types of cases to treat aesthetically. A new surgical method for treating retracted nostril rim was performed in 10 patients, using the combination of auricular composite graft, internal fixation with a retainer, and external continuing suspension with anchoring sutures. The procedure was successful in maintaining the grafted cartilage in the ideal position and in avoiding recurrence of retraction or elevation of the constructed alar rim. The presented method merits consideration as a standard operative approach for correction of retracted nostril rim. PMID:14727081

Hirohi, Toshitsugu; Yoshimura, Kotaro

2004-01-20

124

[Free vascularized bone transfer en bout de chaine].  

UK PubMed Central (United Kingdom)

The vascularized bone proved its capacity to be healed, without resorption even in sclerotic or infected tissue. Reconstruction of the distal part of the finger is often difficult for a pedicle transplant and a conventional bone transplant disappears. So the free vascularized bone transfer (FVBT) is indicated in distal post-traumatic finger amputations. According to the loss of substance to be reconstructed, the vascularised bone is harvested with some pulp, the nail complex or the cartilage of growth for a child. We report our experience of the technique of wrap around modified, of partial transfers of the second toe and the technique of reconstruction of claw nail deformity. The vascularised transfer of the cartilage of growth at the child is essential to allow the growth of the transferred phalanx. The indications are rare, however the children, the musicians or the patients who require fine pinch can benefit from this type of sophisticated reconstructive microsurgery.

Valenti P

2010-12-01

125

Experimental investigation of the nebular formation of chondrule rims and the formation of chondrite parent bodies  

Science.gov (United States)

We developed an experimental setup to test the hypothesis that accretionary rims around chondrules formed in the solar nebula by accretion of dust on the surfaces of hot chondrules. Our experimental method allows us to form dust rims around chondrule analogs while levitated in an inert-gas flow. We used micrometer-sized powdered San Carlos olivine to accrete individual dust particles onto the chondrule analogs at room temperature (20 °C) and at 1100 °C. The resulting dust rims were analyzed by means of two different techniques: non-destructive micro computer tomography, and scanning electron microscopy. Both methods give very similar results for the dust rim structure and a mean dust rim porosity of 60% for the hot coated samples, demonstrating that both methods are equally well suited for sample analysis. The chondrule analog's bulk composition has no measurable impact on the accretion efficiency of the dust. We measured the chemical composition of chondrule analog and dust rim to check whether elemental exchange between the two components occurred. Such a reaction zone was not found; thus, we can experimentally confirm the sharp border between chondrules and dust rims described in the literature. We adopted a simple model to derive the degree of post-accretionary compaction for different carbonaceous chondrites. Moreover, we measured the rim porosity of a fragment of Murchison meteorite, analyzed it with micro-CT and found rim porosities with this technique that are comparable to those described in the literature.

Beitz, E.; Blum, J.; Mathieu, R.; Pack, A.; Hezel, D. C.

2013-09-01

126

Bone tumor  

Science.gov (United States)

Tumor - bone; Bone cancer; Primary bone tumor; Secondard bone tumor ... The cause of bone tumors is unknown. They often occur in areas of rapid bone growth. Possible causes include: Genetic defects passed down ...

127

Quantifying tire, rim, and vehicle effects on ride quality  

Energy Technology Data Exchange (ETDEWEB)

This paper discusses factors influencing vehicle ride discomfort are analyzed to separate those related to tires, rims, vehicles and other sources. Raw data is presented as vertical first harmonic accelerations, and is transformed into quantitative Ride Discomfort numbers using an empirical model developed by NASA. The results indicate each factor's quantitative contribution to ride discomfort. Ride discomfort numbers are compared against subjective data. Results are indicated as both a ride quality number and as a test set rejection parameter. The relation of a combination of known factors into subjective feelings of ride quality is discussed. An explanation is proposed that defines previously ambiguous results in terms of quantifiable sources of vehicle ride discomfort.

Kenny, T.M.

1989-01-01

128

Communities of constructional lips and cup reef rims in Bermuda  

Science.gov (United States)

Constructional lips and cup reef rims are little studied reef features typical of very turbulent conditions. The relatively low diversity community of these structures consists of three components, and algal mat dominated by Herposiphonia secunda, an encrusting calcareous biota characterised by crustose coralline algae and the vermetid gastropod Dendropoma corrodens, which together are the main hermatypic components, and an endolithic component with very abundant boring sponges, polychaetes, crustaceans and sipunculids. In northerly areas of Bermuda, the hydrozoan Millepora alcicornis is a prominent member of the community while to the south the urchin Echinometra lucunter is abundant. On the south side of Bermuda the community traps sediment which is deposited in the void spaces. The environment shows reduced grazing and this may account for the presence of several relict and rare species.

Thomas, Martin L. H.; Stevens, Jo-Anne

1991-01-01

129

The insect-trapping rim of Nepenthes pitchers  

Science.gov (United States)

Carnivorous pitcher plants of the genus Nepenthes capture prey with a pitfall trap that relies on a micro-structured, slippery surface. The upper pitcher rim (peristome) is fully wettable and causes insects to slip by aquaplaning on a thin water film. The high wettability of the peristome is probably achieved by a combination of hydrophilic surface chemistry, surface roughness and the presence of hygroscopic nectar. Insect foot attachment could be prevented by the delayed drainage of the thin water film between the adhesive pad and the surface. Drainage should be faster for insects with a hairy adhesive system; however, they slip equally on the wet peristome. Therefore the stability of the water film against dewetting appears to be the key factor for aquaplaning. New experimental techniques may help to clarify the detailed function of the pitcher plant peristome and to explore its potential for biomimetic applications.

Federle, Walter

2009-01-01

130

Rim enhancement of meningiomas on fast FLAIR imaging  

International Nuclear Information System (INIS)

We investigated the enhancement patterns of meningiomas on fast fluid-attenuated inversion-recovery (FLAIR) images and related them to the size and histology of the tumour and the associated oedema. We studied 30 meningiomas with T2-weighted fast spin-echo (SE) images plus T1-weighted SE images with magnetisation-transfer saturation and fast FLAIR before and after contrast enhancement at 0.5 tesla. There were 21 meningiomas (70%) which showed peripheral (rim) enhancement on fast FLAIR, while only one, which showed heavy central calcification, enhanced peripherally on the SE images. Of the meningiomas with capsular enhancement on fast FLAIR 20 (95%) were more than 2 cm in diameter. The nine 9 smaller meningiomas enhanced homogeneously. This difference was statistically significant pattern (P

2003-01-01

131

Productivity trends and competitive implications for Pacific Rim coal suppliers  

Energy Technology Data Exchange (ETDEWEB)

The growth of labour productivity is a basic characteristic of modern economies. There is a long history of labour productivity increase in the coal industry and no indications that this trend will not continue. If labour productivity continues to grow at a rate that is higher than the growth of wages, it will continue to exert downward pressure on average operating costs and prices. If production capacity continues to grow faster than demand, profit margins will continue to erode. Many productivity improvements are associated with capacity expansions. These trends must be explicitly addressed by Pacific Rim coal producers when evaluating investment and production strategies. Traditional price forecasts and financial decision-making techniques, by themselves, do not adequately address the competitive nature of today's dynamic coal markets. 13 refs., 3 figs.

Sherer, E. (US Bureau of Mines, Washington, DC (United States))

1993-01-01

132

Out of the Blue: The Pacific Rim as a Region  

Directory of Open Access Journals (Sweden)

Full Text Available In 1993, in advance of what was to be the first Asia Pacific Economic Cooperation (APEC) leader’s summit, US president Bill Clinton gave a lecture at Waseda University in Japan. In his speech, Clinton called for the creation of a “community of the Pacific.” The idea of a Pacific community is neither Clinton’s nor the Democratic Party’s invention, however. In the previous decade Ronald Reagan had already used it, going even beyond later conceptualizations, by referring to the 21st century as the Pacific’s century. But Reagan's prophecy concerning the Great Ocean was not new back in the 1980s either. In 1900 then US Secretary of State John Hay wrote: “the Mediterranean is the ocean of the past, the Atlantic the ocean of the present and the Pacific is the ocean of the future.” In a more general manner, as Christopher Coker has observed, the notion of the “Century of the Pacific” is plausible because it is consistent with the idea, popularized by Hegel, that the spirit of civilization is moving toward that part of the globe. Thus, the century of the Pacific has become a kind of zeitgeist. In this paper I undertake a conceptual, historical, and theoretical journey through the “Pacific Rim” or “Asia-Pacific,” as it has been called more recently. Although I will question the utility of the term, I want to make clear that my purpose is only to undertake a critical survey of “the Pacific.” As in any trip, however, one needs a starting point. But, What is the starting point of the Pacific Rim, that geographic zone that has been compared to Pascal’s sphere: “with periphery indeterminable and a center that may be anywhere”?

Arturo Santa-Cruz

2005-01-01

133

Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions.  

UK PubMed Central (United Kingdom)

pH-responsive transcription factors of the Rim101/PacC family govern virulence in many fungal pathogens. These family members control expression of target genes with diverse functions in growth, morphology and environmental adaptation, so the mechanistic relationship between Rim101/PacC and infection is unclear. We have focused on Rim101 from Candida albicans, which we find to be required for virulence in an oropharyngeal candidiasis model. Rim101 affects the yeast-hypha morphological transition, a major virulence requirement in disseminated infection models. However, virulence in the oropharyngeal candidiasis model is independent of the yeast-hypha transition because it is unaffected by an nrg1 mutation, which prevents formation of yeast cells. Here we have identified Rim101 target genes in an nrg1Delta/Delta mutant background and surveyed function using an overexpression-rescue approach. Increased expression of Rim101 target genes ALS3, CHT2, PGA7/RBT6, SKN1 or ZRT1 can partially restore pathogenic interaction of a rim101Delta/Delta mutant with oral epithelial cells. Four of these five genes govern cell wall structure. Our results indicate that Rim101-dependent cell wall alteration contributes to C. albicans pathogenic interactions with oral epithelial cells, independently of cell morphology.

Nobile CJ; Solis N; Myers CL; Fay AJ; Deneault JS; Nantel A; Mitchell AP; Filler SG

2008-11-01

134

Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions.  

Science.gov (United States)

pH-responsive transcription factors of the Rim101/PacC family govern virulence in many fungal pathogens. These family members control expression of target genes with diverse functions in growth, morphology and environmental adaptation, so the mechanistic relationship between Rim101/PacC and infection is unclear. We have focused on Rim101 from Candida albicans, which we find to be required for virulence in an oropharyngeal candidiasis model. Rim101 affects the yeast-hypha morphological transition, a major virulence requirement in disseminated infection models. However, virulence in the oropharyngeal candidiasis model is independent of the yeast-hypha transition because it is unaffected by an nrg1 mutation, which prevents formation of yeast cells. Here we have identified Rim101 target genes in an nrg1Delta/Delta mutant background and surveyed function using an overexpression-rescue approach. Increased expression of Rim101 target genes ALS3, CHT2, PGA7/RBT6, SKN1 or ZRT1 can partially restore pathogenic interaction of a rim101Delta/Delta mutant with oral epithelial cells. Four of these five genes govern cell wall structure. Our results indicate that Rim101-dependent cell wall alteration contributes to C. albicans pathogenic interactions with oral epithelial cells, independently of cell morphology. PMID:18627379

Nobile, Clarissa J; Solis, Norma; Myers, Carter L; Fay, Allison J; Deneault, Jean-Sebastien; Nantel, Andre; Mitchell, Aaron P; Filler, Scott G

2008-07-04

135

78 FR 15920 - Federal Motor Vehicle Safety Standards; Tire Selection and Rims  

Science.gov (United States)

...Federal Motor Vehicle Safety Standards; Tire Selection and Rims AGENCY: National Highway...make it clear that special trailer (ST) tires are permitted to be installed on new trailers...from a vehicle testing requirement that a tire must be retained on its rim when...

2013-03-13

136

Lincoln's Sign: Where Should We Expect on 99mTc-MDP Bone Scintigraphy?  

UK PubMed Central (United Kingdom)

Classical appearance of "Lincoln's sign" on Tc-MDP bone scintigraphy has been described in literature in case of monostotic Paget disease of mandible showing increased radiotracer uptake in the body of mandible. This pattern has also been described as "black beard" sign. The monostotic presentation of Paget disease is rare, and involving the mandible, however, is very unusual. We present a case of carcinoma of the tongue with contiguous spread to the mandible presented in the similar fashion as the earlier reported Lincoln's sign or black beard sign on Tc-MDP bone scintigraphy. This appearance was confirmed with SPECT/CT, and the lytic sclerotic lesion of the mandible was confirmed.

Bal CS; Sahoo MK; Damle N

2013-03-01

137

A Diphenol Oxidase Gene Is Part of a Cluster of Genes Involved in Catecholamine Metabolism and Sclerotization in Drosophila. I. Identification of the Biochemical Defect in Dox-A2 [l(2)37Bf] Mutants  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Phenol oxidase, a complex enzyme, plays a major role in the processes of sclerotization and melanization of cuticle in insects. Several loci have been reported to affect levels of phenol oxidase activity, but to date only one structural locus has been identified [Dox-3F ( 2-53.1+)]. Recently isolate...

Pentz, Ellen Steward; Black, Bruce C.; Wright, Theodore R. F.

138

Rim enhancement of meningiomas on fast FLAIR imaging  

Energy Technology Data Exchange (ETDEWEB)

We investigated the enhancement patterns of meningiomas on fast fluid-attenuated inversion-recovery (FLAIR) images and related them to the size and histology of the tumour and the associated oedema. We studied 30 meningiomas with T2-weighted fast spin-echo (SE) images plus T1-weighted SE images with magnetisation-transfer saturation and fast FLAIR before and after contrast enhancement at 0.5 tesla. There were 21 meningiomas (70%) which showed peripheral (rim) enhancement on fast FLAIR, while only one, which showed heavy central calcification, enhanced peripherally on the SE images. Of the meningiomas with capsular enhancement on fast FLAIR 20 (95%) were more than 2 cm in diameter. The nine 9 smaller meningiomas enhanced homogeneously. This difference was statistically significant pattern (P <0.01). All meningiomas which had associated oedema showed the capsular pattern although their number (6; 20%) was to small to analyse statistically. Only 11 (36%) tumours were examined histologically; peripheral enhancement was observed in all types of meningioma. This pattern may help to differentiate meningiomas from other extra-axial masses. (orig.)

Oguz, K.K.; Cila, A. [Radiology Department, School of Medicine, Hacettepe University, Sihhiye, 06100 Ankara (Turkey)

2003-02-01

139

The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron.  

Science.gov (United States)

Mitochondrial iron uptake is of key importance both for organelle function and cellular iron homoeostasis. The mitochondrial carrier family members Mrs3 and Mrs4 (homologues of vertebrate mitoferrin) function in organellar iron supply, yet other low efficiency transporters may exist. In Saccharomyces cerevisiae, overexpression of RIM2 (MRS12) encoding a mitochondrial pyrimidine nucleotide transporter can overcome the iron-related phenotypes of strains lacking both MRS3 and MRS4. In the present study we show by in vitro transport studies that Rim2 mediates the transport of iron and other divalent metal ions across the mitochondrial inner membrane in a pyrimidine nucleotide-dependent fashion. Mutations in the proposed substrate-binding site of Rim2 prevent both pyrimidine nucleotide and divalent ion transport. These results document that Rim2 catalyses the co-import of pyrimidine nucleotides and divalent metal ions including ferrous iron. The deletion of RIM2 alone has no significant effect on mitochondrial iron supply, Fe-S protein maturation and haem synthesis. However, RIM2 deletion in mrs3/4? cells aggravates their Fe-S protein maturation defect. We conclude that under normal physiological conditions Rim2 does not play a significant role in mitochondrial iron acquisition, yet, in the absence of the main iron transporters Mrs3 and Mrs4, this carrier can supply the mitochondrial matrix with iron in a pyrimidine-nucleotide-dependent fashion. PMID:23800229

Froschauer, Elisabeth M; Rietzschel, Nicole; Hassler, Melanie R; Binder, Markus; Schweyen, Rudolf J; Lill, Roland; Mühlenhoff, Ulrich; Wiesenberger, Gerlinde

2013-10-01

140

The significance of echogenic rim of atypical hepatic hemangioma on ultrasonogram  

International Nuclear Information System (INIS)

To evaluate whether the presence of a peripheral echogenic rim surrounding internal low echogenicity is helpful in the diagnosis of atypical hepatic hemangioma. Within a two-year period, a retrospective review of the sonographic appearances of 24 atypical hemangiomas in 21 patients was performed. Diagnosis was made by dynamic and delayed enhanced CT, MR imaging or clinical follow up for one year, including follow-up sonogram. The sonographic appearances of these hemangiomas were analyzed for pattern and thickness of the echogenic rim, internal echo pattern, shape, and size. Additionally, forty six lesions of hepatoma, metastasis, abscess and intrahepatic cholangiocarcinoma confirmed by pathology within the same period were also evaluated for the presence of echogenic rim. Twenty-three of 24 lesions showed an echogenic rim;these were thick in nine cases, and thin in 14 cases. The thickness of the rim was either uniform(n=10) or eccentric(n=13). The average maximum diameter of atypical hemangioma was 4.4cm(range of diameters, 1.5-12cm). The internal echo pattern was partially or entirely hypoechoic in 15 lesions, homogeneously isoechoic in three, and mixed in six cases. Twenty-one lesions were round, and the shape of three was irregular. The other forty six masses including hepatocellular carcinoma, metastases, cholangiocarcinoma and hepatic abscesses did not show an echogenic rim. The presence of a sonographic echogenic rim in a hepatic mass may help in the diagnosis of hepatic hemangioma.

1996-01-01

 
 
 
 
141

The significance of echogenic rim of atypical hepatic hemangioma on ultrasonogram  

Energy Technology Data Exchange (ETDEWEB)

To evaluate whether the presence of a peripheral echogenic rim surrounding internal low echogenicity is helpful in the diagnosis of atypical hepatic hemangioma. Within a two-year period, a retrospective review of the sonographic appearances of 24 atypical hemangiomas in 21 patients was performed. Diagnosis was made by dynamic and delayed enhanced CT, MR imaging or clinical follow up for one year, including follow-up sonogram. The sonographic appearances of these hemangiomas were analyzed for pattern and thickness of the echogenic rim, internal echo pattern, shape, and size. Additionally, forty six lesions of hepatoma, metastasis, abscess and intrahepatic cholangiocarcinoma confirmed by pathology within the same period were also evaluated for the presence of echogenic rim. Twenty-three of 24 lesions showed an echogenic rim;these were thick in nine cases, and thin in 14 cases. The thickness of the rim was either uniform(n=10) or eccentric(n=13). The average maximum diameter of atypical hemangioma was 4.4cm(range of diameters, 1.5-12cm). The internal echo pattern was partially or entirely hypoechoic in 15 lesions, homogeneously isoechoic in three, and mixed in six cases. Twenty-one lesions were round, and the shape of three was irregular. The other forty six masses including hepatocellular carcinoma, metastases, cholangiocarcinoma and hepatic abscesses did not show an echogenic rim. The presence of a sonographic echogenic rim in a hepatic mass may help in the diagnosis of hepatic hemangioma.

Lee, Choon Hyeong; Ko, Young Tae; Lee, Dong Ho; Lim, Joo Won; Yoon, Yup [Kyunghee Univ. Hospital, Seoul (Korea, Republic of)

1996-11-01

142

76 FR 55708 - Servicing Multi-Piece and Single Piece Rim Wheels; Extension of the Office of Management and...  

Science.gov (United States)

...Administration [Docket No. OSHA-2011-0189] Servicing Multi-Piece and Single Piece Rim Wheels...requirements specified in the Standard on Servicing Multi-Piece and Single Piece Rim Wheels...requirements contained in the Standard on Servicing Multi- Piece and Single Piece Rim...

2011-09-08

143

The Anatomy and Bulk Composition of CAI Rims in the Vigarano (CV3) Chondrite  

Science.gov (United States)

A striking feature of Ca,Al-rich inclusions (CAIs) in chondrites is the presence of mineralogical layers that typically form rim sequences up to 50 micrometers thick [1]. Many ideas regarding the origin of CAI rims have been proposed, but none are entirely satisfactory. The detailed mineralogy and bulk compositions of relatively unaltered CAI rims in the Vigarano (CV3) chondrite described here provide constraints on hypotheses of rim formation. Rim Mineralogy: CAIs in Vigarano consist of melilite (mel)- and spinel (sp)- rich varieties, both of which are rimmed [2]. Around mel-rich objects, the layer sequence is CAI interior --> sp-rich layer (sometimes absent) --> mel/anorthite (anor) layer --> Ti-Al-rich clinopyroxene (Tpx) layer --> Al- diopside (Al-diop) layer --> olivine (ol) +/- Al-diop layer --> host matrix. The sequence around sp-rich objects differs from this in that the mel/anor layer is absent. Both the sp-rich layer around mel-cored CAIs and the cores of sp-rich CAIs in Vigarano are largely comprised of a fine-grained (2 and up to 15 wt% TiO2) and Al-diop layer ( sp + fo --> sp + fo + anor or mel or Tpx) that does not correspond to observed rim sequences. It thus appears that (1) the rim region did not form through crystallization of molten CAIs; and (2) rim layers did not originate solely by the crystallization of a melt layer present on a solid CAI core [4,5]. References: [1] Wark D. A. and Lovering J. F. (1977) Proc. LSC 8th, 95-112. [2] Ruzicka A. and Boynton W. V. (1991) Meteoritics, 26, 390-391. [3] Stolper E. (1982) GCA, 46, 2159-2180. [4] Korina M. I. et al. (1982) LPS XIII, 399- 400. [5] Bunch T. E. and Chang S. (1980) Meteoritics, 15, 270- 271.

Ruzicka, A.; Boynton, W. V.

1993-07-01

144

Long follow-up of cranofacial cleft treated by the folded vascularized calvarial bone.  

UK PubMed Central (United Kingdom)

Craniofacial clefts are relatively rare. Tessier proposed a classification of craniofacial clefts. A Tessier no. 10 cranial facial defect is very rare. There are few reports regarding the reconstruction of the orbital rim and roof of a Tessier number 10 cleft. In this paper, we present the reconstruction of the orbital rim and roof by a folded vascularized calvarial bone and the long-term follow-up results.

Toriyama K; Hatano H; Yagi S; Saito K; Kamei Y

2013-05-01

145

Measurement of the wear of railway wheel-rims by radioisotopes  

International Nuclear Information System (INIS)

[en] A relative measuring method based on the ratio of the activities of prepared railway wheel-rim surfaces before and after the wear test was developed and tested. In a 5 ?m thick plated layer 59Fe isotope was electrolitically deposited onto the rim surface. The relative decrease of the recorded intensities and the application of the Wickers-track technique provide a rapid and reliable method to measure the wear of railway wheel-rim under operation conditions. (Sz.J.)

1980-01-01

146

18F-FDG PET/CT bone/bone marrow findings in Hodgkin's lymphoma may circumvent the use of bone marrow trephine biopsy at diagnosis staging  

International Nuclear Information System (INIS)

Accurate staging of Hodgkin's lymphoma (HL) is necessary in selecting appropriate treatment. Bone marrow trephine biopsy (BMB) is the standard procedure for depicting bone marrow involvement. BMB is invasive and explores a limited part of the bone marrow. 18F-FDG PET/CT is now widely used for assessing response to therapy in HL and a baseline study is obtained to improve accuracy. The aim of this retrospective analysis was to assess whether routine BMB remains necessary with concomitant 18F-FDG PET/CT. Data from 83 patients (newly diagnosed HL) were reviewed. All patients had received contrast-enhanced CT, BMB and 18F-FDG PET/CT. Results of BMB were not available at the time of 18F-FDG PET/CT imaging. Seven patients had lymphomatous involvement on BMB. Four patients had bone involvement on conventional CT (two with negative BMB). All patients with bone marrow and/or bone lesions at conventional staging were also diagnosed on 18F-FDG PET/CT scan. PET/CT depicted FDG-avid bone/bone marrow foci in nine additional patients. Four of them had only one or two foci, while the other had multiple foci. However, the iliac crest, site of the BMB, was not involved on 18F-FDG PET/CT. Osteolytic/sclerotic lesions matching FDG-avid foci were visible on the CT part of PET/CT in three patients. MRI ordered in three other patients suggested bone marrow involvement. Interim and/or end-therapy 18F-FDG PET/CT documented response of FDG-avid bone/bone marrow foci to chemotherapy in every patient. 18F-FDG PET/CT highly improves sensitivity for diagnosis of bone/bone marrow lesions in HL compared to conventional staging. (orig.)

2010-01-01

147

Osteosclerotic prostate cancer metastasis to murine bone are enhanced with increased bone formation.  

UK PubMed Central (United Kingdom)

Spontaneous development of osteoblastic lesions of prostate cancer (PCa) in mice is modeled by orthotopic (intraprostatic) deposition of neoplastic cells followed by an extremely long latency associated with low incidence of spontaneous bone metastasis. Intracardial injection results in overt bone metastases only with osteoclastic PCa cells (i.e., PC-3). Herein, we report that androgen independent osteoblastic PCa cells readily colonize bone when in a high remodeling state. SCID/Beige mice were subjected to periods of intermittent human parathyroid hormone 1-34 (hPTH) exposure, followed by an intracardiac infusion of osteoblastic C4-2 PCa cells. At the time of PCa infusion, analysis of bone turnover markers from mice treated with hPTH revealed significant increases in osteocalcin (55.06 +/- 7.5 vs. 74.01 +/- 18.5 ng/ml) and TRAcP-5b (3.3 +/- 0.6 vs. 4.81 +/- 0.8 U/l), but no change in type I collagen C-terminal teleopeptide levels relative to control mice. Analysis of femoral cancellous bone architecture revealed significant increases in bone mineral density, trabecular thickness (0.056 +/- 0.002 vs. 0.062 +/- 0.001 mm) and porosity, but significant decreases in connectivity density and trabecular number in hPTH treated mice relative to controls. By 8 weeks post-infusion, 70% of mice pre-treated with hPTH demonstrated detectable serum prostate specific antigen (PSAs) ranging between 2 and 18.8 ng/ml. Immuno-histochemical labeling of femurs for PSA and pan-Cytokeratin revealed the presence of significant tumor cell nests in marrow and trabecular spaces. These results suggest that: (1) local bone physiology is an important factor for developing osteoblastic/sclerotic PCa bone metastases in murine hosts; (2) the establishment of osteosclerotic PCa bone metastases in mice is enhanced by alterations that drive bone formation.

Gomes RR Jr; Buttke P; Paul EM; Sikes RA

2009-01-01

148

Intraosseous pneumatocysts of the ilium: findings on radiographs and CT scans  

International Nuclear Information System (INIS)

[en] CT scans demonstrated a localized collection of gas adjacent to a normal sacroiliac joint in 5 patients. In each case the lesion was sharply demarcated by a thin sclerotic rim. A benign bone cyst was confirmed histologically in 2 cases. The radiologist should be aware of this appearance so as to avoid invasive procedures based on a misdiagnosis of infection or neoplasm

1984-01-01

149

Ice cream cone rim has secondary droplet trap and droplet return hole  

UK PubMed Central (United Kingdom)

An ice cream cone wafer has a wide inlet converging from the rim towards the base in a triangular form. The cone has a secondary droplet trap that is an annular flange forming part of the wafer structure.

150

Methamphetamine: The Current Threat in East Asia and the Pacific Rim. Drug Intelligence Brief.  

Science.gov (United States)

Methamphetamine production, trafficking, and abuse are problems affecting every country in the Asian and the Pacific Rim Regions. As early as World War II, methamphetamine abuse had become a scourge for Japan. During World War II, the Japanese Government ...

2003-01-01

151

Metallurgical analysis of rim cracking in an lp steam turbine disc  

International Nuclear Information System (INIS)

An investigation of the nature of in-service cracking in LP turbine rotors encountered in a PWR nuclear power plant was performed. The investigation was based on a metallurgical evaluation of disc rim samples from one of the two rotors involved. The program included a detailed magnetic particle inspection of the rim samples, in-depth metallographic and fractographic examinations of cracked blade attachment steeples and chemical analyses of the disc material

1980-01-01

152

Metallurgical analysis of rim cracking in an lp steam turbine disc. [PWR  

Energy Technology Data Exchange (ETDEWEB)

An investigation of the nature of in-service cracking in LP turbine rotors encountered in a PWR nuclear power plant was performed. The investigation was based on a metallurgical evaluation of disc rim samples from one of the two rotors involved. The program included a detailed magnetic particle inspection of the rim samples, in-depth metallographic and fractographic examinations of cracked blade attachment steeples and chemical analyses of the disc material.

Burghard, H.C. Jr.

1980-09-01

153

Rim and flame signs: postgadolinium MRI findings specific for non-CNS intramedullary spinal cord metastases.  

UK PubMed Central (United Kingdom)

BACKGROUND AND PURPOSE: No highly specific MR imaging features distinguishing ISCMs from primary cord masses have been described. Our purpose was to retrospectively compare peripheral enhancement features on postgadolinium MR imaging of ISCMs with primary intramedullary cord masses. MATERIALS AND METHODS: A consecutive group of patients with firmly diagnosed ISCM (45 patients with 64 ISCMs) and a comparison group with consecutive pathologically proved primary intramedullary spinal cord masses (64 patients with 64 primary spinal cord masses: ependymoma, astrocytoma, hemangioblastoma, ganglioglioma, and cavernous malformation) were included. MR images were evaluated for 2 specific signs on postgadolinium images: a "rim" sign (more intense thin rim of peripheral enhancement around an enhancing lesion) and "flame" sign (ill-defined flame-shaped region of enhancement at the superior/inferior lesion margins). The frequency of rim and/or flame signs in ISCMs and primary cord masses was compared (?2 test). For ISCMs, the maximal dimension of the enhancing lesion was correlated with the presence of rim or flame signs (t test). RESULTS: Rim and flame signs, alone and in combination, were seen more frequently in ISCMs than in primary cord masses (P<.0001 for each). Specificity and sensitivity, respectively, for diagnosing ISCMs among spinal cord masses on a per-patient basis were the following: rim sign, 97%, 47%; flame sign, 97%, 40%; at least 1 sign, 94%, 60%; and both signs concurrently, 100%, 27%. In the ISCM group, the presence of either a rim or flame sign correlated with a larger measured maximum enhancing lesion size (P=.0065 and P=.0012, respectively). CONCLUSIONS: The rim and flame signs are common in and specific for ISCM and are rare in primary spinal cord masses.

Rykken JB; Diehn FE; Hunt CH; Eckel LJ; Schwartz KM; Kaufmann TJ; Wald JT; Giannini C; Wood CP

2013-04-01

154

[Reliability of porous coating metal-backed cups: advantages and adverse effect of a posterior elevated rim polyethylene liner  

UK PubMed Central (United Kingdom)

PURPOSE OF THE STUDY: We analyzed primary implantation of the Duraloc cup associated with a self-locking Muller stem at 9.6 +/- 1.6 years (8.6-11.4). Because of its particular 3/5 semi-spherical shape, the Duraloc cup has been associated with a high rate of dislocation. The objective of this study was to evaluate the efficacy of an anti-dislocation posterior elevated rim polyethylene liner on long-term dislocation rate and wear. MATERIAL AND METHODS: The series included 89 arthroplasties implanted between 1991 and 1993 in 82 patients, mean age 56.8 +/- 12.6 years (17.2-87). The Postel-Merle-d'Aubligné (PMA) score and subjective evaluation with a visual analog scale were used for the clinical assessment. Changes in the bone-cup interface, cup migration, and polyethylene wear were assessed radiographically. RESULTS: At last follow-up, the PMA function score was 16.2 +/- 1.9 points (10-18) (81% good, very good and excellent results). The postoperative x-rays showed a low incidence of lucent lines and osteolysis, respectively 8% and 4%. Mean annual linear polyethylene wear was 0.11 +/- 0.066 mm (0.03-0.57) and only 4% of the cups showed wear greater than 0.2 mm/year. Wear was correlated with the presence of acetabular osteolysis and high activity level. Two cups migrated (3-4 cm medialization). Three cups were revised, one for deep infection, one for recurrent dislocation, and one for dislocation associated with major wear. The rate of dislocation was 2.2% (two cases). Overall survival was 97.3% at 9.6 years (95%CI 0.93-1.0). DISCUSSION: Compared with other series in the literature using this implant, the presence of a posterior elevated rim polyethylene liner reduced the rate of instability and did not increase wear. The Duraloc cup is recognized as a reliable implant exhibiting excellent osteointegration and a low rate of migration. The presence of a posterior rim is associated with a lower rate of dislocation and does not increase wear. It can thus be proposed for primary implantation. The posterosuperior position for the liner is recommended.

Girard J; Laffargue P; Decoulx J; Migaud H

2005-09-01

155

"Early esophageal rim enhancement": a new sign of esophageal cancer on dynamic CT.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To retrospectively assess a new CT finding of esophageal cancer, "early esophageal rim enhancement". MATERIALS AND METHODS: Sixty-two patients with pathological proven esophageal squamous cell carcinoma who underwent dual phase CT imaging (arterial and venous phases) were enrolled. Two blinded observes independently evaluated presence of partial or circumferential enhancement of the esophageal periphery on arterial (early esophageal rim enhancement) and venous phase CT images. The radiological assessment was compared with the pathological T-stages. Agreement between the observers was also evaluated with a Cohen' kappa value. RESULTS: Pathologic results found 19, 12, 30 and 1 lesions, respectively for T1, T2, T3 and T4 stages. Agreement between two readers was substantial (?=0.71). Esophageal rim enhancement was observed in 0, 4, 24 and 1 lesions respectively for T1, T2, T3 and T4 stages at the arterial phase, whereas no esophageal rim enhancement could be detected at the venous phase. Early esophageal rim enhancement was more frequently observed in T3/T4 lesions than T1/T2 lesions with statistical significance (p<0.0001). The sensitivity, specificity and accuracy for the diagnosis of T3 or T4 lesion were 80.6%, 87.1% and 83.9%, respectively. CONCLUSION: Early esophageal rim enhancement may be helpful for assessing invasion into the adventitia.

Umeoka S; Okada T; Daido S; Ikeuchi T; Koyama T; Harigai M; Tanaka E; Sakai Y; Togashi K

2013-03-01

156

Bone within a bone  

Energy Technology Data Exchange (ETDEWEB)

The 'bone within a bone' appearance is a well-recognized radiological term with a variety of causes. It is important to recognize this appearance and also to be aware of the differential diagnosis. A number of common conditions infrequently cause this appearance. Other causes are rare and some remain primarily of historical interest, as they are no longer encountered in clinical practice. In this review we illustrate some of the conditions that can give the bone within a bone appearance and discuss the physiological and pathological aetiology of each where known.

Williams, H.J.; Davies, A.M. E-mail: wendy.turner@roh.nhs.uk; Chapman, S

2004-02-01

157

Positioning of bone segments during navigated surgery.  

UK PubMed Central (United Kingdom)

PURPOSE: In navigated craniomaxillofacial surgery, bone segments often have to be repositioned. To keep them reliably in the desired place during referencing and osteosynthesis, a miniature external distractor can be used. MATERIALS AND METHODS: The use of a miniature external mandibular distractor is shown in a case of bilateral lateral orbital rim advancement during endocrine orbitopathy decompression surgery. RESULTS: The advantages of using a distractor are the possibility of changing the fragment position incrementally in all directions during intraoperative control with the navigated pointer and the small size of the appliance. CONCLUSIONS: Bone segments can be manipulated intraoperatively with a miniature distractor in navigated surgery.

Hierl T; Krause M; Kruber D; Hümpfner-Hierl H

2013-02-01

158

Subsidence and basin-fill architecture of a lignite-bearing salt rim syncline: insights into rim syncline evolution and salt diapirism  

Science.gov (United States)

In the last decades, salt-withdrawal basins achieved much attention due to their significant hydrocarbon potential like in the Gulf of Mexico, along the Brazilian passive margin and in northern Germany. The Helmstedt-Staßfurt salt wall and the related Schöningen rim syncline are an ideal natural laboratory to study the evolution of salt-withdrawal basins in detail. An excellent data set of 358 wells allows a detailed assessment of the basin-fill architecture. The aim was to expand on the classical cross-section based rim syncline analysis by the use of 3D models and basin simulations. The Helmstedt-Staßfurt salt wall is 70 km long, 6-8 km wide and one of the most important diapiric structures in northern Germany, based on the economically significant lignite-bearing rim synclines. The analysed Schöningen rim syncline, located on the southwestern side of the Helmstedt-Staßfurt structure, is 8 km long and 3 km wide. The basin-fill is up to 366 m thick and contains 13 major lignite seams with thicknesses between 0.1 and 30 m. Cross-sections perpendicular to the basin axis indicate that the basin-fill has a pronounced lenticular shape. This shape varies from more symmetric in the NW to clearly asymmetric in the SE. It coincides to the broadening of the salt diapir from NW to SE. The geometry of the rim syncline therefore seems to be a function of the diapir morphology. Sediments close to a diapir margin tend to be sheared by the rising diapir and this effect is probably enhanced where the diapir becomes broader and as a result, the related rim syncline is more asymmetric. Isopach maps imply a two-fold depocentre evolution. The depocentre migrated over time towards the salt wall and also showed some distinct shifts parallel to the salt wall. The shifts parallel to salt wall were abrupt, in contrast to the more gradual migration of the depocentres perpendicular to the salt wall. The basin modelling part of the study was carried out with the software PetroMod®, which focused on the burial history of the rim syncline. Modeling results also show the progressive migration of the rim syncline depocenter towards the salt wall. The extracted geohistory curve shows initial rapid subsidence between 57 and 50 Ma and more moderate subsidence from 50 to 34 Ma. This pattern is interpreted to reflect salt migration from the source layer into the salt wall. The initial salt-withdrawal rate was rapid but later decreased probably due to depletion of the source layer. From a regional perspective, the sediments associated with the salt wall vary in age along strike. The oldest sediments are present at the northwestern and southeastern ends of the structure. The youngest sediments are present towards the central part of the salt wall. This age pattern implies that the break-through of the salt wall was initiated at the edges. The evolution of the Helmstedt-Staßfurt salt wall can be subdivided into the three stages reactive, active and passive diapirism. Initial salt rise was probably triggered by extension. Diapirism was enhanced due to contraction during the Late Cretaceous. The salt movements in the Tertiary were mainly driven by sediment loading in the rim synclines.

Brandes, C.; Pollok, L.; Schmidt, C.; Wilde, V.; Winsemann, J.

2012-04-01

159

Hypoechoic rim of chronically inflamed prostate, as seen at TRUS: histopathologic findings  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study is to correlate the findings of peripheral hypoechoic rim, seen at transrectal ultrasonography (TRUS) in chronic prostatitis patients, with the histopthologic findings. Seven patients with pathologically proven chronic prostatitis were involved in this study. The conspicuity of the peripheral hypoechoic prostatic rim, seen at TRUS, was prominent and subtle, and to determine its histopathologic nature, the microscopic findings were reviewed. In five of seven cases (71%), TRUS demonstrated a prominent peripheral hypoechoic rim. Microscopic examination revealed that inflammatory cell infiltration of prostatic glandular tissue was severe in three cases (42.9%), moderate in two (28.6%), and minimal in two (28.6%). In all seven cases, the common histopathologic findings of peripheral hypoechoic rim on TRUS were loose stromal tissues, few prostatic glands, and sparse infiltration by inflammatory cells. The peripheral hypoechoic rim accompanying prostatic inflammation and revealed by TRUS reflects a sparsity of prostate glandular tissue and is thought to be an area in which inflammatory cell infiltration is minimal.

Lee, Hak Jong [Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Choe, Ghee Young; Kim, Seung Hyup [Seoul National University College of Medicine, Seoul (Korea, Republic of); Seong, Chang Gyu [Kyungpook National University College of Medicine, Taegu (Korea, Republic of)

2001-09-01

160

Hypoechoic rim of chronically inflamed prostate, as seen at TRUS: histopathologic findings  

International Nuclear Information System (INIS)

The purpose of this study is to correlate the findings of peripheral hypoechoic rim, seen at transrectal ultrasonography (TRUS) in chronic prostatitis patients, with the histopthologic findings. Seven patients with pathologically proven chronic prostatitis were involved in this study. The conspicuity of the peripheral hypoechoic prostatic rim, seen at TRUS, was prominent and subtle, and to determine its histopathologic nature, the microscopic findings were reviewed. In five of seven cases (71%), TRUS demonstrated a prominent peripheral hypoechoic rim. Microscopic examination revealed that inflammatory cell infiltration of prostatic glandular tissue was severe in three cases (42.9%), moderate in two (28.6%), and minimal in two (28.6%). In all seven cases, the common histopathologic findings of peripheral hypoechoic rim on TRUS were loose stromal tissues, few prostatic glands, and sparse infiltration by inflammatory cells. The peripheral hypoechoic rim accompanying prostatic inflammation and revealed by TRUS reflects a sparsity of prostate glandular tissue and is thought to be an area in which inflammatory cell infiltration is minimal.

2001-01-01

 
 
 
 
161

Star Formation in Bright Rimmed Clouds. I. Millimeter and Submillimeter Molecular Line Surveys  

CERN Multimedia

We present the results of the first detailed millimeter and submillimeter molecular line survey of bright rimmed clouds, observed at FCRAO in the CO (J=1-0), C18O (J=1-0), HCO+ (J=1-0), H13CO+ (J=1-0), and N2H+ (J=1-0) transitions, and at the HHT in the CO (J=2-1), HCO+ (J=3-2), HCO+ (J=4-3), H13CO+ (J=3-2), and H13CO+ (J=4-3) molecular line transitions. The source list is composed of a selection of bright rimmed clouds from the catalog of such objects compiled by Sugitani et al. (1991). We also present observations of three Bok globules done for comparison with the bright rimmed clouds. We find that the appearance of the millimeter CO and HCO+ emission is dominated by the morphology of the shock front in the bright rimmed clouds. The HCO+ (J=1-0) emission tends to trace the swept up gas ridge and overdense regions which may be triggered to collapse as a result of sequential star formation. Five of the seven bright rimmed clouds we observe seem to have an outflow, however only one shows the spectral line blue...

De Vries, C H; Snell, R L; Vries, Christopher H. De; Narayanan, Gopal; Snell, Ronald L.

2002-01-01

162

A prospective analysis of CT density measurements of bone metastases after treatment with zoledronic acid  

Energy Technology Data Exchange (ETDEWEB)

The objective was to prospectively determine CT density changes in bone metastases, before and after intravenous zoledronic acid for a maximum period of 12 months. Twenty-three consecutive patients presented with bone metastases and underwent therapy with zoledronic acid from December 2004. All patients underwent CT of the chest, abdomen, and pelvis. Bone density, measured in Hounsfield units (HU), was determined by segmenting lesions in the same anatomical area of the metastasis sites on the axial images of the sequential series of CT examinations. The effects of zoledronic acid were evaluated by calculating absolute and relative increases in bone density. The patients presented with multiple metastases in 65% of the cases. When compared with the baseline, all groups demonstrated a significant increase in bone density, which significantly (p < 0.01) correlated with the number of zoledronic acid administrations. There was increased bone density of at least 100% in 57%, and an increase of at least 50% in 87% of the patients. This increase was significant in both lytic and sclerotic metastases after 3 months of therapy. No significant bone density difference was found in normal-appearing bone. Bone density measured by CT increases at metastatic sites after zoledronic acid treatment, regardless of the type of metastasis, in contrast to apparently normal bone. (orig.)

Quattrocchi, Carlo C.; Dell' Aia, Paola; Piciucchi, Sara; Grasso, Rosario F.; Zobel, Bruno B. [Centro Interdisciplinare per la Ricerca Bio-Medica, Department of Radiology, Rome (Italy); Santini, Daniele; Vincenzi, Bruno; Tonini, Giuseppe [University Campus Bio-Medico di Roma, Department of Oncology, Rome (Italy); Leoncini, Emanuele [Statistica Sanitaria, University La Sapienza, Rome (Italy)

2007-12-15

163

Temperature distribution in the plastic rim of a flange wheel for mine locomotives  

Energy Technology Data Exchange (ETDEWEB)

The temperature distribution in the plastic rim was calculated on a concussion-spring system taking into account the physical properties of the plastic material Vulkollan 27 and the geometry of wheel and rail. These calculations were largely confirmed by tests carried out on the roller test rig of the Institute for Mining and Steelworking of the Rhenish-Westphalian Technical University at Aachen. It was found that a heat enclave is formed in the centre of the plastic rim, the core of which exhibits the highest temperature. From there the temperature reduces in bands towards the outer zones of the rim. It is also noticeable that the isotherms decrease towards components located laterally on the flange wheel, something closely related to the fact that the vulcanisation between plastic and steel ring fails at these points first. (orig./MOS).

Schepers, W.; Henkel, W.

1987-04-01

164

Flight testing of the AIM/RIM-7M missile, preflight analysis  

Science.gov (United States)

The AIM/RIM-7M missile is the most recent version of the AIM-7 missile series. It is in the preproduction phase and has completed most of the preproduction flight test evaluation. A description is presented of the preflight simulation techniques used, taking into account the value of the techniques in predicting the results of actual flights. The AIM/RIM-7M is a semiactive, radar-guided homing missile with sophisticated onboard digital processing. It may be launched from either an aircraft or a surface system. To a large degree, the AIM/RIM-7M represents problems typical of all guided missiles. The described techniques are directly applicable to radar-guided missiles and generically to all types of guided missiles. Attention is given to simulation bay activities, the anechoic chamber, aspects of RF control, the target array, computer models, aspects of preflight simulations, and the test setup.

Hicks, W.; Greenberg, E.

1981-11-01

165

Study and simulation of the rim effect in rep fuel rods  

International Nuclear Information System (INIS)

The RIM effect has been discovered fifteen years ago during the examination of first irradiated rods at more than 45 gWJ/TU in experimental reactors. The rods observation revealed a continuously degradation of the granular structure in the pellet skin, jointly to the porosity increase in this area. This study proposes a RIM formation and development mechanism for high combustion level. The first part presents the simulation of the fission gases in the fuel fraction concerned by the RIM. In the proposed model the gas bubbles increase is bound to the volume fraction of restructured fuel. This model allows the determination of the pores volume fraction in the fuel, the average size of these pores and the volume distribution of the fission gases between the bubbles and the fuel matrix. (A.L.B.)

1996-01-01

166

Mechanical fracture study of nuclear fuel high burn-up structure (HBS or RIM) during annealing test  

International Nuclear Information System (INIS)

The ceramics used in Power Water Reactors ar made of uranium dioxide. Irradiated at high Burn-up, they present a characteristic zone in periphery called High Burn-Up Structure or RIM zone with micrometer pores containing over-pressurized gas bubbles. Annealing texts simulating incidental or accidental reactor situations, a strong release of the RIM zone is observed. We have considered that the fission gas release mechanism is the mechanical fracture of the RIM grain boundaries. The we have compared the different types of mechanical stress applied to a grain boundary with the fracture stress of the oxide. The first stress is due to RIM over-pressurized gas bubbles, these bubbles apply a stress field determined at a microscopic level i.e. at the gas bubbles scale and its local environment. The second stress is generated by the Pellet-Cladding Mechanical Interaction (PCMI). This stress applies a stress field on a microscopic scale i.e. at the RIM zone and its overall environment. The last stress is occurred by a strain due to the RIM structural evolution during annealing test. The experimental results show that microscopic and macroscopic stress fields to do not explain the RIM grain boundary fracture during annealing test. The stresses induced by the RIM structural evolution as a function of the temperature is a possible mechanism to explain the overall mechanical behavior of the RIM zone during annealing test. (author)

2010-01-01

167

Orthodontic movement of impacted cuspid in fibrodysplastic bone: a case report.  

Science.gov (United States)

A case of orthodontic replacement of impacted cuspid in fibrodysplastic maxillary bone in a 12-year-old girl is reported. Fibrodysplastic bone is classically described as a fibrous bone without osteoblastic rimming. It is well known that orthodontic forces lead to tooth movement through proliferation and increased activity of bone cells (osteoblasts and osteoclasts). The reported case clinically support the latest histological studies suggesting that in fibrodisplastic bone osteoblasts are present but altered in shape and therefore difficult to recognize in sections. PMID:19716453

Colella, Giuseppe; Itro, Angelo; Perillo, Letizia; Cannavale, Rosangela

2009-08-27

168

Haemocytes play a commensal rôle in the synthesis of the dihydroxybenzoate required as a precursor for sclerotization of the egg case (ootheca) in the cockroach Periplaneta americana (L).  

Science.gov (United States)

The secretions of the two colleterial glands give rise to the walls of the ootheca which, when hardened, serve to protect fertilised eggs in the cockroach P. americana. The larger left gland (LCG) secretes a ?-D-glucoside of 3,4-dihydroxybenzoate, several proteins (oothecins), calcium oxalate crystals and a latent phenoloxidase enzyme. The smaller right gland (RCG) secretes a ?-glucosidase. When the two secretions mix in the genital vestibulum, the glucoside is hydrolyzed to glucose and free dihydroxybenzoate, which is then oxidized by the phenoloxidase to the o-benzoquinone, which cross-links the oothecins Scanning and thin section electron microscopy (EM) showed haemocytes adhering to the LCG. The haemocytes were obtained by washing the gland with insect saline; and, when they were incubated with labelled tyrosine, they showed an enhanced ability to decarboxylate L-p-tyrosine to tyramine and then deaminate and oxidize tyramine to give p-hydroxyphenylacetate. After removal of adhering haemocytes, the LCG was no longer able to decarboxylate tyrosine. Injection of ?-ecdysone into the abdomens of recently emerged adult females inhibited synthesis of a phenolic glucoside in the developing LCG but not of ?-glucosidase produced by RCG. Furthermore, injecting inhibitors of the decarboxylase and monoamineoxidase enzymes partly closed down synthesis in vivo of the phenolic glucoside by LCG. Therefore, in the adult female cockroach, tyramine was converted to p-hydroxyphenylacetate in the haemocytes and then transferred to the gland where it was hydroxylated to 3,4-dihydroxyphenylacetate, which gave rise to a dihydroxybenzoate. Evidence suggested that biosynthesis of the oothecal sclerotizing agent could be controlled by juvenile hormone (JH) acting on the LCG or on haemocytes adhering to the gland. PMID:20716385

Whitehead, D L

2010-08-18

169

Haemocytes play a commensal role in the synthesis of the dihydroxybenzoate required as a precursor for sclerotization of the egg case (ootheca) in the cockroach Periplaneta americana (L).  

UK PubMed Central (United Kingdom)

The secretions of the two colleterial glands give rise to the walls of the ootheca which, when hardened, serve to protect fertilised eggs in the cockroach P. americana. The larger left gland (LCG) secretes a ?-D-glucoside of 3,4-dihydroxybenzoate, several proteins (oothecins), calcium oxalate crystals and a latent phenoloxidase enzyme. The smaller right gland (RCG) secretes a ?-glucosidase. When the two secretions mix in the genital vestibulum, the glucoside is hydrolyzed to glucose and free dihydroxybenzoate, which is then oxidized by the phenoloxidase to the o-benzoquinone, which cross-links the oothecins Scanning and thin section electron microscopy (EM) showed haemocytes adhering to the LCG. The haemocytes were obtained by washing the gland with insect saline; and, when they were incubated with labelled tyrosine, they showed an enhanced ability to decarboxylate L-p-tyrosine to tyramine and then deaminate and oxidize tyramine to give p-hydroxyphenylacetate. After removal of adhering haemocytes, the LCG was no longer able to decarboxylate tyrosine. Injection of ?-ecdysone into the abdomens of recently emerged adult females inhibited synthesis of a phenolic glucoside in the developing LCG but not of ?-glucosidase produced by RCG. Furthermore, injecting inhibitors of the decarboxylase and monoamineoxidase enzymes partly closed down synthesis in vivo of the phenolic glucoside by LCG. Therefore, in the adult female cockroach, tyramine was converted to p-hydroxyphenylacetate in the haemocytes and then transferred to the gland where it was hydroxylated to 3,4-dihydroxyphenylacetate, which gave rise to a dihydroxybenzoate. Evidence suggested that biosynthesis of the oothecal sclerotizing agent could be controlled by juvenile hormone (JH) acting on the LCG or on haemocytes adhering to the gland.

Whitehead DL

2011-06-01

170

[Correlation between neuroretinal rim and optic disc areas in normal melanoderm and glaucoma patients  

UK PubMed Central (United Kingdom)

BACKGROUND: To evaluate optic disc size and its relationship with neuroretinal rim areas. MATERIAL AND METHODS: The study was prospective; 400 hundred patients with 292 glaucomatous and 108 non glaucomatous were enrolled in this study. Optic disc size quantification was assessed by the use of Goldmann 3 mirror contact lens; diameter reading were adjusted by the magnification factor of the lens, squares of the disc and the cupping were calculated using an ellipse formula, the neuroretinal rim area was then obtained by reducing the cupping area from the whole optic disc area. RESULTS: The mean age of the sample was 36.80 years (sd: 15.68 years).The average value of the vertical disc diameter was 2.045 mm (sd: 0.254) for glaucoma patients and 1.966 mm (sd: 0.237) in the control group; p<0.001. Neuroretinal rim area was 1.886 mm(2) (sd: 0.675) in the glaucoma group; and 2.165 mm(2) (sd: 0.425) in the control one; p<0. 004. In the glaucoma group, 72.97% of large optic disc were found (vertical diameter over 1.90 mm); and 63.80% in the control one. In the control group, neuroretinal rim area was wider in the large optic discs compared to the small discs, p<0.001, Anova test. Neuroretinal rim area was thinner in the glaucoma large disc compared to the control, p<0.005, Student test. Meanwhile, there was no difference in the medium and the small discs in the glaucoma and control groups; p > 0.005, Student Newmann test. CONCLUSION: Neuroretinal rim areas are thinner in the large glaucoma discs compared to the non glaucoma large discs. In Africa, this parameter could be helpful in the diagnosis and survey of glaucoma patients.

Balo KP; Mihluedo H; Djagnikpo PA; Akpandja MS; Béchetoille A

2000-01-01

171

Bone scan  

Science.gov (United States)

A bone scan involves injecting a radioactive material (radiotracer) into a vein. The substance travels through your ... body. The camera takes pictures of how much radiotracer collects in the bones. If a bone scan ...

172

Bone Diseases  

Science.gov (United States)

Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly ... childhood and your teens, your body adds new bone faster than it removes old bone. After about ...

173

Bone Cancer  

Science.gov (United States)

Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another ... more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and ...

174

Physical and functional interaction between yeast Pif1 helicase and Rim1 single-stranded DNA binding protein  

Science.gov (United States)

Pif1 helicase plays various roles in the maintenance of nuclear and mitochondrial genome integrity in most eukaryotes. Here, we used a proteomics approach called isotopic differentiation of interactions as random or targeted to identify specific protein complexes of Saccharomyces cerevisiae Pif1. We identified a stable association between Pif1 and a mitochondrial SSB, Rim1. In vitro co-precipitation experiments using recombinant proteins indicated a direct interaction between Pif1 and Rim1. Fluorescently labeled Rim1 was titrated with Pif1 resulting in an increase in anisotropy and a Kd value of 0.69 µM. Deletion mutagenesis revealed that the OB-fold domain and the C-terminal tail of Rim1 are both involved in interaction with Pif1. However, a Rim1 C-terminal truncation (Rim1?C18) exhibited a nearly 4-fold higher Kd value. Rim1 stimulated Pif1 DNA helicase activity by 4- to 5-fold, whereas Rim1?C18 stimulated Pif1 by 2-fold. Hence, two regions of Rim1, the OB-fold domain and the C-terminal domain, interact with Pif1. One of these interactions occurs through the N-terminal domain of Pif1 because a deletion mutant of Pif1 (Pif1?N) retained interaction with Rim1 but did not exhibit stimulation of helicase activity. In light of our in vivo and in vitro data, and previous work, it is likely that the Rim1–Pif1 interaction plays a role in coordination of their functions in mtDNA metabolism.

Ramanagoudr-Bhojappa, Ramanagouda; Blair, Lauren P.; Tackett, Alan J.; Raney, Kevin D.

2013-01-01

175

{sup 18}F-FDG PET/CT bone/bone marrow findings in Hodgkin's lymphoma may circumvent the use of bone marrow trephine biopsy at diagnosis staging  

Energy Technology Data Exchange (ETDEWEB)

Accurate staging of Hodgkin's lymphoma (HL) is necessary in selecting appropriate treatment. Bone marrow trephine biopsy (BMB) is the standard procedure for depicting bone marrow involvement. BMB is invasive and explores a limited part of the bone marrow. {sup 18}F-FDG PET/CT is now widely used for assessing response to therapy in HL and a baseline study is obtained to improve accuracy. The aim of this retrospective analysis was to assess whether routine BMB remains necessary with concomitant {sup 18}F-FDG PET/CT. Data from 83 patients (newly diagnosed HL) were reviewed. All patients had received contrast-enhanced CT, BMB and {sup 18}F-FDG PET/CT. Results of BMB were not available at the time of {sup 18}F-FDG PET/CT imaging. Seven patients had lymphomatous involvement on BMB. Four patients had bone involvement on conventional CT (two with negative BMB). All patients with bone marrow and/or bone lesions at conventional staging were also diagnosed on {sup 18}F-FDG PET/CT scan. PET/CT depicted FDG-avid bone/bone marrow foci in nine additional patients. Four of them had only one or two foci, while the other had multiple foci. However, the iliac crest, site of the BMB, was not involved on {sup 18}F-FDG PET/CT. Osteolytic/sclerotic lesions matching FDG-avid foci were visible on the CT part of PET/CT in three patients. MRI ordered in three other patients suggested bone marrow involvement. Interim and/or end-therapy {sup 18}F-FDG PET/CT documented response of FDG-avid bone/bone marrow foci to chemotherapy in every patient. {sup 18}F-FDG PET/CT highly improves sensitivity for diagnosis of bone/bone marrow lesions in HL compared to conventional staging. (orig.)

Moulin-Romsee, Gerard [Universite Paris 7, Service de Medicine Nucleaire, Hopital Saint-Louis, Assistance Publique-Hopitaux de Paris (France); Institut Curie, Nuclear Medicine, Paris (France); Hindie, Elif; Filmont, Jean-Emmanuel; Moretti, Jean-Luc [Universite Paris 7, Service de Medicine Nucleaire, Hopital Saint-Louis, Assistance Publique-Hopitaux de Paris (France); Cuenca, Xavier; Brice, Pauline; Sibon, David [Hopital Saint-Louis, Haemato-Oncology, Paris (France); Decaudin, Didier; Anitei, Marcela [Institut Curie, Haematology, Paris (France); Benamor, Myriam [Institut Curie, Nuclear Medicine, Paris (France); Briere, Josette [Hopital Saint-Louis, Pathology, Paris (France); Kerviler, Eric de [Hopital Saint-Louis, Radiology, Paris (France)

2010-06-15

176

Imaging of the intramedullary bone infarcts and their complications  

International Nuclear Information System (INIS)

[en] Radiographic, CT, bone scan and MR patterns of the infarcts of the metaphyses and diaphyses of tubular bones and their main complications are presented. Bone marrow infarcts are located in the medullary cavity of long bones. They most often involve the lower limbs. They are commonly associated with necrosis of the epiphyses and have common origin. In contrast to necrosis of the epiphyses, bone infarcts may present specific complications. They are most often detected incidentally, because of their clinical latency. Radiographic and CT changes appear late, showing localized areas of increased density with irregular rims, or sharply demarcated shells of calcification. Earlier changes are demonstrated by bone scan and MRI. MR pattern is characteristic, showing an area of hyposignal on T1- and T2-weighted sequences, with irregular rims, and sometimes small areas of fat signal. Their complications include cystic formation and malignant degeneration (sarcoma and particularly malignant fibrous histiocytoma). An unusual complication, infection involving bone infarcts is also presented. (authors). 12 refs., 8 figs

1995-01-01

177

Cryo-electron tomography reveals a critical role of RIM1? in synaptic vesicle tethering.  

UK PubMed Central (United Kingdom)

Synaptic vesicles are embedded in a complex filamentous network at the presynaptic terminal. Before fusion, vesicles are linked to the active zone (AZ) by short filaments (tethers). The identity of the molecules that form and regulate tethers remains unknown, but Rab3-interacting molecule (RIM) is a prominent candidate, given its central role in AZ organization. In this paper, we analyzed presynaptic architecture of RIM1? knockout (KO) mice by cryo-electron tomography. In stark contrast to previous work on dehydrated, chemically fixed samples, our data show significant alterations in vesicle distribution and AZ tethering that could provide a structural basis for the functional deficits of RIM1? KO synapses. Proteasome inhibition reversed these structural defects, suggesting a functional recovery confirmed by electrophysiological recordings. Altogether, our results not only point to the ubiquitin-proteasome system as an important regulator of presynaptic architecture and function but also show that the tethering machinery plays a critical role in exocytosis, converging into a structural model of synaptic vesicle priming by RIM1?.

Fernández-Busnadiego R; Asano S; Oprisoreanu AM; Sakata E; Doengi M; Kochovski Z; Zürner M; Stein V; Schoch S; Baumeister W; Luci? V

2013-05-01

178

Isotopically selective RIMS of rare radionuclides by double-resonance excitation with cw lasers  

Energy Technology Data Exchange (ETDEWEB)

Double-resonance, Resonance Ionization Mass Spectroscopy (RIMS) using two single-frequency dye lasers and a CO{sub 2} laser for photoionization has been shown to be both extremely sensitive and highly selective. Measurements on the radioisotope {sup 210}Pb have demonstrated optical selectivity in excess of 10{sup 9} and detection limits of less than 1 femtogram.

Bushaw, B.A.; Munley, J.T.

1990-09-01

179

Isotopically selective RIMS of rare radionuclides by double-resonance excitation with cw lasers  

International Nuclear Information System (INIS)

[en] Double-resonance, Resonance Ionization Mass Spectroscopy (RIMS) using two single-frequency dye lasers and a CO2 laser for photoionization has been shown to be both extremely sensitive and highly selective. Measurements on the radioisotope 210Pb have demonstrated optical selectivity in excess of 109 and detection limits of less than 1 femtogram

1990-01-01

180

Investigation of hydride rim effect on failure of zircaloy-4 cladding with tube burst test  

International Nuclear Information System (INIS)

To promote a better understanding of failure behavior of high burnup PWR fuel rods during reactivity initiated accidents (RIAs), tube burst tests have been performed with artificially hydrided Zircaloy-4 specimens at room temperature and at 620 K. Pressurization rate was increased to a maximum of 3.4 GPa/s in order to simulate rapid pellet/cladding mechanical interaction (PCMI) that occurs in high burnup fuel rods during a pulse-irradiation in the Nuclear Safety Reactor (NSRR). Hydrogen content in the specimens ranged from 150 to 1,050 ppm. Hydrides were accumulated in the cladding periphery and formed 'hydride rim' (radially-localized hydride layer) as observed in high burnup PWR fuel claddings. The hydrided cladding tubes failed with an axial crack at the room temperature tests. Brittle fracture appeared in the hydride rim, and failure morphology was similar to that observed in the NSRR experiments. The hydrides rim obviously reduced burst pressure and residual hoop strain at the tests. The residual hoop strain was very small even at 620 K when thickness of the hydride rim exceeded 18% of cladding thickness. The present result accordingly indicates an important role of the hydrides layer in high burnup fuel rod failure under RIA conditions. (author)

2005-01-01

 
 
 
 
181

Peritumoral bone marrow edema accompanying benign giant cell tumor  

International Nuclear Information System (INIS)

[en] To evaluate the frequency of peritumoral bone marrow(BM) edema accompanying benign giant cell tumor(GCT) of the appendicular bone by magnetic resonance(MR) imaging and to correlate MRI findings with those of plain radiography and bone scintigraphy. Eighteen cases of pathologically proven benign GCT of the appendicular bone were retrospectively analyzed using MR images, plain radiographs and bone scintigrams. A plain radiography was available in 15 cases, and a scintigram in six. Marrow edema was defined as peritumoral signal changes which were of homogeneous intermediate or low signal intensity(SI) onT1WI and high SI on T2WI, relative to the SI of normal BM, and homogeneous enhancement on Gd-DTPA -enhanced T1WI. The transition zone, sclerotic margin and aggressiveness of the lesion were assessed on the basis of plain radiographs. BM edema seen on MR images was correlated with plain radiographic and scintigraphic findings. 1. Peritumoral BM edema was seen on MR images in 10 of 18 cases (55.5%). 2. In 8 of 15 cases for which plain radiographs were available, MR imaging revealed BM edema. In six of these eight, transition zone was wide, while in two it was narrow. Six of seven patients without marrow edema showed a wide transition zone, and in one this was narrow. There was significant correlation between BM edema shown by MR imaging and the transition zone seen on plain radiographs (x2, p

1998-01-01

182

Enchondroma on bone scan in a patient with breast cancer  

International Nuclear Information System (INIS)

A 45-year-old postmenopausal woman with breast cancer was treated with modified radical mastectomy and radiotherapy. She remained clinically well for two years but then complained of pain in the left upper arm during a routine follow-up visit with her physician. A roentgenogram of the left proximal humerus showed a densely sclerotic, nonhomogeneous, 2 x 6 cm lesion with stippled calcification, the appearance of which was most consistent with a mature enchondroma or bone infarct. Because metastatic breast cancer was also a possibility, a technetium Tc 99m methyldiphosphonate (MDP) bone scan was done, revealing diffuse uptake in the left proximal humeral lesion, without any other area of involvement. Although radiologically the lesion appeared benign and stable, the history of breast cancer, abnormal bone scan, and pain could not be ignored, and open surgical bone biopsy was done. From deep within the lesion at the core of the metaphysis of the proximal left humerus, the surgeon removed an enchondroma, but found no evidence of metastatic disease. Follow-up MDP bone scans after six months and four years were unchanged.

1984-01-01

183

76 FR 69720 - NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...  

Science.gov (United States)

...Commission [ Docket No. ER12-295-000] NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based...the above-referenced proceeding of NaturEner Rim Rock Wind Energy, LLC's application for market-based rate...

2011-11-09

184

Rim15p-mediated regulation of sucrose utilization during molasses fermentation using Saccharomyces cerevisiae strain PE-2.  

UK PubMed Central (United Kingdom)

Inherited loss-of-function mutations in the Rim15p-mediated stress-response pathway contribute to the high fermentation rate of sake yeast strains. In the present study, we found that disruption of the RIM15 gene in ethanol-producing Saccharomyces cerevisiae strain PE-2 accelerated molasses fermentation through enhanced sucrose utilization following glucose starvation.

Inai T; Watanabe D; Zhou Y; Fukada R; Akao T; Shima J; Takagi H; Shimoi H

2013-06-01

185

Stereological evolution of the rim structure in PWR-fuels at prolonged irradiation: Dependencies with burn-up and temperature  

International Nuclear Information System (INIS)

[en] The stereology of the rim-structure was studied for PWR-fuels up to the ninth irradiation cycle, achieving maximum local burn-ups of 240 GWd/tM and beyond. At intermediate radial positions (0.55 0 c = 0.29. Rim-cavities are expected to remain closed at least up to this limit

2006-08-01

186

Dense bone - too much bone: Radiological considerations and differential diagnosis. Pt. 2  

Energy Technology Data Exchange (ETDEWEB)

In conclusion, the attempt has been made to demonstrate that three major forms of new bone formation exist: reactive, neoplastic, and the newborn or relative skeletal sclerosis in congenital (developmental) disorders. A classification of skeletal disorders has been presented and four major groups have been selected from the nine categories in this classification. These are: congenital-developmental, metabolic and endocrine, benign neoplasms and malignant neoplasms. In all four categories a large group of entities which may present with new bone (sclerosis) are listed and are discussed in some, but limited, detail. A number of these entities in each of the four categories are illustrated. Some difficulty is encountered in considering the mechanisms for the production of bony sclerosis in the group of congenital-developmental disorders. In such entities as osteopetrosis, the overproduction of cartilage cords and subsequent excessive mineralization is known to be responsible for the dense bone. However, in various skeletal dysplasias (e.g. pyknodysostosis, van Bucherm disease), the exact mechanism for the development of the diffuse sclerotic process is not clearly understood. In the metabolic and endocrine category, the situation as to mechanism is less unclear in considering the reason for the development of bony sclerosis. Yet even in evaluating disorders such as renal osteodystrophy, the reactive bony sclerosis in the presence of secondary hyperparathyroidism and osteomalacia is a source of speculation with no definite proof, as yet.

Jacobson, H.G.

1985-02-01

187

Dense bone - too much bone: Radiological considerations and differential diagnosis. Pt. 2  

International Nuclear Information System (INIS)

In conclusion, the attempt has been made to demonstrate that three major forms of new bone formation exist: reactive, neoplastic, and the newborn or relative skeletal sclerosis in congenital (developmental) disorders. A classification of skeletal disorders has been presented and four major groups have been selected from the nine categories in this classification. These are: congenital-developmental, metabolic and endocrine, benign neoplasms and malignant neoplasms. In all four categories a large group of entities which may present with new bone (sclerosis) are listed and are discussed in some, but limited, detail. A number of these entities in each of the four categories are illustrated. Some difficulty is encountered in considering the mechanisms for the production of bony sclerosis in the group of congenital-developmental disorders. In such entities as osteopetrosis, the overproduction of cartilage cords and subsequent excessive mineralization is known to be responsible for the dense bone. However, in various skeletal dysplasias (e.g. pyknodysostosis, van Bucherm disease), the exact mechanism for the development of the diffuse sclerotic process is not clearly understood. In the metabolic and endocrine category, the situation as to mechanism is less unclear in considering the reason for the development of bony sclerosis. Yet even in evaluating disorders such as renal osteodystrophy, the reactive bony sclerosis in the presence of secondary hyperparathyroidism and osteomalacia is a source of speculation with no definite proof, as yet. (orig.).

1985-01-01

188

"Repair of cranial bone defects using endochondral bone matrix gelatin in rat "  

Directory of Open Access Journals (Sweden)

Full Text Available Bone matrix gelatin (BMG) has been used for bone induction intramuscularly and subcutaneously by many investigators since 1965. More recently, some of the researchers have used BMG particles for bone repair and reported various results. In present study for evaluation of bone induction and new bone formation in parital defects, BMG particles were used in five groups of rats. The BMG was prepared as previously described using urist method. The defects wee produced with 5 –mm diameter in pariteal bones and filled by BMG particles. No BMG was used in control group.For evaluation of new bone formation and repair, the specimens were harvested on days 7 , 14 , 21 and 28 after operation. The samples were processed histologically, stained by H& E, alizarin red S staining, and Alcian blue, and studied by a light microscope.The results are as follows:In control group: Twenty-eight days after operation a narrow rim of new bone was detectable attached to the edge of defect.In BMG groups: At day 7 after operation young chondroblast cells appeared in whole area of defect. At 14th day after operation hypertrophic chondrocytes showed by Alcian blue staining and calcified cartilage were detectable by Alizarin red S staining. The numerous trabeculae spicules, early adult osteocytes and highly proliferated red bone marrow well developed on dayd 21 . finally typic bone trabeculae with regulated osteoblast cells and some osteoclast cells were detectable at day 28 after operation. In conclusion,BMG could stimulate bone induction and new bone formation in bony defects. So, it seems that BMG could be a godd biomaterial substance for new bone inducation in bone defects

"Sobhani A; Sargolzaei F; Akbari M; Rafighdoost H; Abbasi M; Kashani IR "

2001-01-01

189

Feasibility and safety of transcatheter closure of atrial septal defects with deficient posterior rim.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To evaluate the feasibility and safety of percutaneous closure of complex secundum-type atrial septal defects (ASD) in patients with posterior-inferior rim deficiency. BACKGROUND: Transcatheter approach is the method of choice for ASD closure; however, up to now 20% of the defects are not considered suitable for percutaneous intervention because of the lack of surrounding rims, especially the posterior-inferior. METHODS: A total of 268 patients were evaluated between March 2005 and April 2011 for ASD closure. Twenty-four patients (9%) were not considered suitable for a percutaneous intervention and referred to surgery due to inadequate rims or a large defect diameter. Out of the remaining 244 patients, 25 (10,2%) had posterior-inferior rim deficiency and represent our study group. RESULTS: After failure of the conventional approach, alternative techniques were attempted. In 16 patients, an adjusted deployment and alignment maneuver approach was successful. In 5 other patients, a slide out technique was successfully performed by exploiting the right upper pulmonary vein. Finally in the remaining 4 patients, ASD closure was obtained by completely re-orienting the system with a jugular approach. No peri-procedural complications occurred, and at 12-month transesophageal echocardiography evaluation no residual shunt could be detected. CONCLUSIONS: Our data show the feasibility of percutaneous approach for ASD closure in presence of a deficient posterior-inferior rim. The procedural success is strictly related to correct sizing and demonstration of a balloon notch on fluoroscopy. Long-term follow-up supports efficacy of the procedure in these selected cases.

Papa M; Gaspardone A; Fragasso G; Sidoti F; Agricola E; Gioffrè G; Iamele M; Margonato A

2013-06-01

190

BONE PLUG  

UK PubMed Central (United Kingdom)

A device for insertion into an amputated bone and a method for inserting the device into an amputated bone are described. The device comprises a stem configured to be inserted into a cavity of the amputated bone. The device further comprises a head coupled to the stem. The head has a diameter greater than the diameter of the stem. The head further has a flat surface configured to interface with a severed surface of the amputated bone. The head and stem are fabricated from a moldable porous matrix material configured to promote bone growth within the matrix. A device for bridging a first amputated bone and a second amputated bone is also described.

NUTTER ROBERT

191

Imaging features of low-grade central osteosarcoma of the long bones and pelvis  

International Nuclear Information System (INIS)

[en] To determine the age and gender distribution and imaging features of low-grade central osteosarcoma (LGCOS) of the long bones and pelvis and to discuss our findings in the context of lesions for which LGCOS has been mistaken. We reviewed 99 cases of LGCOS collected between 1919 and 2002 from our institution and pathology consultation files. Adequate imaging was available in 70 cases (36 radiographs only, 17 radiographs/CT, 12 radiographs/MRI, 2 radiographs/CT/MRI, 2 CT only, 1 MRI only, 5 bone scans). Patient average age was 30.1±14.2 years, with a slight female predominance. The femur and tibia were the most common long bones involved (29 and 20 each) with the majority of these tumors arising around the knee, followed by the fibula, radius, humerus and ulna (four, three, two and one case each). Flat bones were involved in six cases (three pelvis, one rib, two scapulae). Short tubular bones were involved in five cases (two metatarsal, two phalanges, one clavicle). The lesion extended to the end of the affected long bone in 22 of 59 cases. Lesions were large at presentation (mean 7.9±4.6 cm, range 2-24). Four radiographic patterns were identified: lytic with varying amounts of thick and coarse trabeculation (n=22), predominantly lytic with few thin, incomplete trabecula (n=21), densely sclerotic (n=17) and mixed lytic and sclerotic (n=10). Lesions were benign-appearing overall with focally aggressive features. CT or MRI demonstrated cortical breech or extension into the soft tissues in all cases. LGCOS has a variable appearance on radiographs. A frequent pattern is a slow-growing large intracompartmental fibro-osseous lesion with varying amounts of septal ossification associated with focal areas of aggression. A homogeneously sclerotic pattern was also noted. Imaging with CT or MRI was helpful in every instance in our series in identifying areas of soft tissue extension or cortical disruption suggestive of a low-grade malignancy. (orig.)

2004-01-01

192

Forsterite-rich accretionary rims around Ca,Al-rich inclusions from the reduced CV3 chondrite Efremovka  

Science.gov (United States)

It was suggested that multilayered accretionary rims composed of ferrous olivine, andradite, wollastonite, salite-hedenbergitic pyroxenes, nepheline, and Ni-rich sulfides around Allende Ca, Al-rich inclusions (CAIs) are aggregates of gas-solid condensates which reflect significant fluctuations in physico-chemical conditions in the slowly cooling solar nebula and grain/gas separation processes. In order to test this model, we studied the mineralogy of accretionary rims around one type A CAI (E104) and one type B CAI (E48) from the reduced CV3 chondrite Efremovka, which is less altered than Allende. In contrast to the Allende accretionary rims, those in Efremovka consist of coarse-grained (20-40 ?m), anhedral forsterite (Fa1-8), Fe,Ni-metal nodules, amoeboid olivine aggregates (AOAs) and fine-grained CAIs composed of Al-diopside, anorthite, and spinel, forsterite. Although the fine-grained CAIs, AOAs and host CAIs are virtually unaltered, a hibonite-spinel-perovskite CAI in the E48 accretionary rim experienced extensive alteration, which resulted in the formation of Fe-rich, Zn-bearing spinel, and a Ca, Al, Si-hydrous mineral. Forsterites in the accretionary rims typically show an aggregational nature and consist of small olivine grains with numerous pores and tiny inclusions of Al-rich minerals. No evidence for the replacement of forsterite by enstatite was found; no chondrule fragments were identified in the accretionary rims. We infer that accretionary rims in Efremovka are more primitive than those in Allende and formed by aggregation of high-temperature condensates around host CAIs in the CAI-forming regions. The rimmed CAIs were removed from these regions prior to condensation of enstatite and alkalies. The absence of andradite, wollastonite, and hedenbergite from the Efremovka rims may indicate that these rims sampled different nebular regions than the Allende rims. Alternatively, the Ca, Fe-rich silicates rimmimg Allende CAIs may have resulted from late-stage metasomatic alteration, under oxidizing conditions, of original Efremovka-like accretionary rims. The observed differences in O-isotope composition between forsterite and Ca, Fe-rich minerals in the Allende accretionary rims (Hiyagon, 1998) suggest that the oxidizing fluid had an 16O-poor oxygen isotopic composition.

Krot, Alexander N.; Ulyanov, Alexander A.; Meibom, Anders; Keil, Klaus

2001-05-01

193

Low Bone Density (Osteopenia)  

Science.gov (United States)

... are here Home » Low Bone Density Low Bone Density Low bone density is when your bone density ... people with normal bone density. Detecting Low Bone Density A bone density test will determine whether you ...

194

Rim versus Non-Rim States in the Arctic Region: Prospects for a Zero-Sum Game or a Win-Win One?  

Directory of Open Access Journals (Sweden)

Full Text Available The present paper aims to develop a critical approach on one of the most urgent energy security challenges: the Arctic region. Until recently, it was considered to be a frozen desert, upon which no one raised any legal demands or interests. The global warming, the technological development and the increased need for energy resources had transformed the frozen High North into a very hot spot, where states like US, Canada, Norway, Denmark or Russia started an energy race that threatens to escalate. The Arctic became a strategic area given its opportunities: besides the energy resources, new commercial routes could become available for a longer period of time. But, due to legal uncertainties, the lack of coherent and direct legal procedures of international law, the Arctic game is an open one, in which any state can intervene and ask for a solution that is suitable for its interests. This aspect complicates even further the already unstable region. Some of the actors see the region as an international area, as a common good, where everyone has the right to explore or exploit, while the rim states see the Arctic in sovereign rights terms. Therefore, the game tends to complicate as non-rim players (the EU, China, Japan, NATO and South Korea) want to intervene in the region and try to influence its development.

Ana-Maria Ghimi?

2013-01-01

195

The effects of a displaced dorsal rim fracture on outcomes after volar plate fixation of a distal radius fracture.  

UK PubMed Central (United Kingdom)

INTRODUCTION: The purpose of this study was to determine whether a displaced dorsal rim fracture has an adverse effect on wrist function after volar plate fixation of a dorsally displaced distal radius fracture (DRF). MATERIALS AND METHODS: Two matched cohorts of 23 matched patients, one with a displaced dorsal rim fracture >2mm (group 1), and the other without a dorsal rim fracture (group 2) were analysed in this study of volar locking plate fixation for dorsally unstable DRFs. The two cohorts were analysed for differences in wrist function and wrist pain, radiographic parameters and arthritic grades of radiocarpal joints. Displacement of dorsal rim fragments and diameters of the retained articular portions of dorsal rims in group 1 were measured. RESULTS: No significant difference was found between the two groups in overall wrist function or wrist pain. Mean displacement of dorsal rims in group 1 was 3.0mm and the mean diameter of the retained articular portion of dorsal articular wall was 2.0mm. No significant difference was found between the two groups in terms of any radiographic parameters or the arthritic grading of radiocarpal joints. CONCLUSION: A displaced dorsal rim fracture does not appear to affect outcomes adversely after volar locking plate fixation of dorsally displaced DRFs.

Kim JK; Cho SW

2012-02-01

196

Optic disc rim area to retinal nerve fiber layer thickness correlation: comparison of diabetic and normal tension glaucoma eyes.  

UK PubMed Central (United Kingdom)

PURPOSE: To compare the correlation between optic disc rim area and retinal nerve fiber layer thickness (rim-RNFL correlation) in diabetic eyes with non-progressive RNFL defects and normal tension glaucoma (NTG) eyes. METHODS: Seventy-three eyes of 73 patients with preperimetric or early NTG and 25 eyes of 25 type II diabetes patients with a non-progressive RNFL defect for ?5 years were enrolled in this retrospective cohort study. Rim areas and RNFL thicknesses were measured by Heidelberg retina tomography (HRT II) and by optical coherence tomography (Cirrus OCT), in global and 12 clock-hour parameters. Diabetic eyes were evaluated whether they were above the 95 % prediction interval (PI) for the rim-RNFL correlation of NTG. RESULTS: A significant linear rim-RNFL correlation was observed in NTG eyes globally and at all clock-hours, except in the 4 and 9 o'clock areas, (0.08 < r (2) < 0.56, P < 0.05). Eighty-four percent of the diabetic eyes were above the 95 % PI of the rim-RNFL correlation of NTG in ?2 clock-hours, as compared with 36 % of the eyes in the global parameter. CONCLUSIONS: The eyes of diabetic patients with non-progressive RNFL were well-differentiated from NTG eyes by the rim-RNFL correlation.

Suh MH; Kim SH; Park KH; Yu HG; Huh JW; Kim DM

2013-03-01

197

CT Guided Bone Biopsy Using a Battery Powered Intraosseous Device.  

UK PubMed Central (United Kingdom)

PURPOSE: To evaluate the feasibility of a battery powered intraosseous device to perform CT-fluoroscopy guided bone biopsy. METHODS: Retrospective analysis of 12 patients in whom bone specimen were acquired from different locations under CT-fluoroscopy guidance using the OnControl bone marrow biopsy system (OBM, Vidacare, Shavano Park, TX, USA). Data of the 12 were compared to a historic cohort in whom the specimen were acquired using the classic Jamshidi Needle, as reference needle using manual force for biopsy. RESULTS: Technical success was reached in 11 of 12 cases, indicated by central localisation of the needle within the target lesion. All specimen sampled were sufficient for histopathological workup. Compared to the historical cohort the time needed for biopsy decreased significantly from 13 ± 6 to 6 ± 4 min (P = 0.0001). Due to the shortened intervention time the radiation dose (CTDI) during CT-fluoroscopy was lowered significantly from 169 ± 87 to 111 ± 54 mGy × cm (P = 0.0001). Interventional radiologists were confident with the performance of the needle especially when using in sclerotic or osteoblastic lesions. CONCLUSION: The OBM is an attractive support for CT-fluoroscopy guided bone biopsy which is safe tool and compared to the classical approach using the Jamshidi needle leading to significantly reduced intervention time and radiation exposure.

Schnapauff D; Marnitz T; Freyhardt P; Collettini F; Hartwig K; Jöhrens K; Hamm B; Kroencke T; Gebauer B

2013-10-01

198

Direct measurement of the separation factor with 235U-enriched UF5 particles in RIMLIS  

International Nuclear Information System (INIS)

The collection system for 235U-enriched UF5 particles was designed for a newly-built reactor with much higher pumping capacity in molecular laser isotope separation at RIKEN (RIMLIS). A multi-jet low pressure impactor was used as a collector for ultrafine UF5 particles. ?-Spectra of the collected product particles were measured with a Si detector to determine the separation factor directly from the isotopic ratio of the product particles. The separation factor was also obtained from the measurements of the isotopic ratio of the residual UF6 gas and fractional conversion of UF6 gas. The separation factor obtained from the isotopic ratio of collected product particles agreed well with the separation factor obtained from residual gas phase isotopic ratio. We confirmed that we collected the UF5 particles which were enriched 235U by RIMLIS. (author)

1990-11-01

199

Ultrasonic inspection method and system for detection of steeple cracking in turbine disk rims  

International Nuclear Information System (INIS)

Steam turbine disks which operate under high cyclic stress in a moist environment can develop cracks in the disk-rim steeples. Detection of these cracks using nondestructive testing methods is necessary to assure safe operation and avoid unnecessary disk replacement. Both magnetic particle (MT) and ultrasonic testing (UT) can be used to inspect the steeples; however, UT can be used without removing the blades. A system for inspecting bladed steeples has been developed that can be applied on a range of disks including those in Westinghouse, General Electric, and Allis Chalmers turbines. The system performs an inspection as the turbine is rotated at slow speeds over turning rolls. This procedure greatly reduces inspection time because the inspection can be done without deblading the disk or resetting the inspection equipment for different rim segments

1990-01-01

200

Ablation of high-temperature superconductor studied by resonance ionization mass spectrometry (RIMS)  

International Nuclear Information System (INIS)

Laser ablation of bulk high-temperature superconductor (HTS) material provides a useful means of producing high-quality HTS thin films. Mass spectrometric probes of the ablation plume provide a microscopic understanding of the ablation event and plume development as well as providing a process monitor for the thin-film production. Resonance ionization mass spectrometry (RIMS) detection of the ablated neutral species supplies valuable physical information about the ablation event necessary for developing models of the process. Time-of-flight/RIMS detection of Cu, Y, and BaO ablated from YBa2Cu3O7-x indicates the ablation involves post-desorption gas phase collisions, which influence the ablation chemistry and dynamics (e.g., angular and velocity distributions). Approximately equal velocities are observed for all neutral species at constant ablation laser fluence. In addition, BaO exhibits a rotational temperature far less than the directed translational temperature

1991-02-01

 
 
 
 
201

Variability of myocardial perfusion dark rim Gibbs artifacts due to sub-pixel shifts  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Gibbs ringing has been shown as a possible source of dark rim artifacts in myocardial perfusion studies. This type of artifact is usually described as transient, lasting a few heart beats, and localised in random segments of the myocardial wall. Dark rim artifacts are known to be unpredictably variable. This article aims to illustrate that a sub-pixel shift, i.e. a small displacement of the pixels with respect to the endocardial border, can result in different Gibbs ringing and hence different artifacts. Therefore a hypothesis for one cause of dark rim artifact variability is given based on the sub-pixel position of the endocardial border. This article also demonstrates the consequences for Gibbs artifacts when two different methods of image interpolation are applied (post-FFT interpolation, and pre-FFT zero-filling). Results Sub-pixel shifting of in vivo perfusion studies was shown to change the appearance of Gibbs artifacts. This effect was visible in the original uninterpolated images, and in the post-FFT interpolated images. The same shifted data interpolated by pre-FFT zero-filling exhibited much less variability in the Gibbs artifact. The in vivo findings were confirmed by phantom imaging and numerical simulations. Conclusion Unless pre-FFT zero-filling interpolation is performed, Gibbs artifacts are very dependent on the position of the subendocardial wall within the pixel. By introducing sub-pixel shifts relative to the endocardial border, some of the variability of the dark rim artifacts in different myocardial segments, in different patients and from frame to frame during first-pass perfusion due to cardiac and respiratory motion can be explained. Image interpolation by zero-filling can be used to minimize this dependency.

Ferreira Pedro; Gatehouse Peter; Kellman Peter; Bucciarelli-Ducci Chiara; Firmin David

2009-01-01

202

Bone Densitometry  

Medline Plus

Full Text Available X-Plain Bone Densitometry Reference Summary Introduction Bone densitometry is a helpful radiological test for detecting the early stages of osteoporosis, before any symptoms occur. ...

203

Bone Metastasis  

Science.gov (United States)

... may be reprinted for personal, noncommercial use only. Bone metastasis By Mayo Clinic staff Original Article: http://www.mayoclinic.com/health/bone-metastasis/DS01206 Definition Symptoms Causes Risk factors Preparing for ...

204

Bone Densitometry  

Medline Plus

Full Text Available ... well as bed rest, weakens the bones. A diet low in dairy products and calcium can make ... with oral medication, staying active and a healthy diet. Bone density tests are available and very helpful ...

205

Bone Spurs  

Science.gov (United States)

Bone spurs Basics In-Depth Expert Answers Resources Reprints A single copy of this article may be reprinted for personal, noncommercial use only. Bone spurs By Mayo Clinic staff Original Article: http:// ...

206

[Bone metastases].  

UK PubMed Central (United Kingdom)

Malignant urological tumours account for a relevant number of patients who develop bone metastasis throughout the course of their disease. Diagnosis of bone metastasis is mostly achieved by imaging studies including plain X-ray, computed tomography or magnetic resonance tomography. Differential diagnosis between benign and malignant processes in the bone can be sometimes challenging so that minimally or open operative biopsy of the bone becomes necessary in rare cases. After diagnosis of bone metastasis medical treatment using bisphosphonates or denosumab should be initiated in order to prevent skeletal complications. Therapeutic goals for symptomatic bone metastasis are the reduction of tumour associated pain and stabilization of the bone. Pathologic fractures are mostly being treated using either minimally invasive or open operative techniques for stabilizing the segment of the bone or spine. In case of accompanying neurologic symptoms immediate intervention and decompression of the neural structures is warranted in order to prevent irreversible neurologic deficits.

Ohlmann CH

2013-03-01

207

Bone Basics  

Science.gov (United States)

This is an activity (on page 2 of the PDF) about the two main components of bone - collagen and minerals (like calcium) - and how they each contribute to its flexibility and strength. Learners will submerge 3 chicken bones in water, bleach, and vinegar, wait 24 hours, then observe and test each bone. This resource includes information about how nanoscientists are trying to produce artificial analogs to these components and relates to linked video, DragonflyTV Nano: Bone Regrowth.

Twin Cities Public Television, Inc.

2008-01-01

208

Infarct rim: effect of hyperglycemia on direct current potential and [14C]2-deoxyglucose phosphorylation.  

UK PubMed Central (United Kingdom)

Focal ischemia was produced by occlusion of the right middle cerebral artery (MCA) in normo- and hyperglycemic rats. In the cortical infarct rim, regional [14C]2-deoxyglucose [( 14C]2-DG) phosphorylation was correlated to spontaneous transient changes in extracellular potassium recorded as direct current (DC) potential deflections. In normoglycemic rats the DC potential showed transient but recurrent deflections in the first hours following MCA occlusion. The 2-DG phosphorylation was elevated by 200% in the same area. In contrast, hyperglycemic rats had no, or a single, deflection of the DC potential in the rim, and the 2-DG phosphorylation remained normal. The same pattern was obtained by application of 3 M KCl to the exposed cortex. In normoglycemia potassium application resulted in recurrent deflections of the DC potential, and 2-DG phosphorylation increased in most parts of the hemisphere. Hyperglycemic animals had a nearly stable DC potential, and 2-DG phosphorylation increased only in the tissue area situated directly below the site of potassium application. The results indicate that metabolism in the cortical infarct rim is stimulated by spontaneous and recurrent changes in extracellular potassium--a phenomenon that may be related to spreading depression--and that the metabolism remained normal in the same area in hyperglycemic animals owing to an inhibition of transient increases of extracellular potassium.

Nedergaard M; Astrup J

1986-10-01

209

Infarct rim: effect of hyperglycemia on direct current potential and [14C]2-deoxyglucose phosphorylation.  

Science.gov (United States)

Focal ischemia was produced by occlusion of the right middle cerebral artery (MCA) in normo- and hyperglycemic rats. In the cortical infarct rim, regional [14C]2-deoxyglucose [( 14C]2-DG) phosphorylation was correlated to spontaneous transient changes in extracellular potassium recorded as direct current (DC) potential deflections. In normoglycemic rats the DC potential showed transient but recurrent deflections in the first hours following MCA occlusion. The 2-DG phosphorylation was elevated by 200% in the same area. In contrast, hyperglycemic rats had no, or a single, deflection of the DC potential in the rim, and the 2-DG phosphorylation remained normal. The same pattern was obtained by application of 3 M KCl to the exposed cortex. In normoglycemia potassium application resulted in recurrent deflections of the DC potential, and 2-DG phosphorylation increased in most parts of the hemisphere. Hyperglycemic animals had a nearly stable DC potential, and 2-DG phosphorylation increased only in the tissue area situated directly below the site of potassium application. The results indicate that metabolism in the cortical infarct rim is stimulated by spontaneous and recurrent changes in extracellular potassium--a phenomenon that may be related to spreading depression--and that the metabolism remained normal in the same area in hyperglycemic animals owing to an inhibition of transient increases of extracellular potassium. PMID:3760045

Nedergaard, M; Astrup, J

1986-10-01

210

Infarct rim: effect of hyperglycemia on direct current potential and (/sup 14/C)2-deoxyglucose phosphorylation  

Energy Technology Data Exchange (ETDEWEB)

Focal ischemia was produced by occlusion of the right middle cerebral artery (MCA) in normo- and hyperglycemic rats. In the cortical infarct rim, regional (/sup 14/C)2-deoxyglucose (( /sup 14/C)2-DG) phosphorylation was correlated to spontaneous transient changes in extracellular potassium recorded as direct current (DC) potential deflections. In normoglycemic rats the DC potential showed transient but recurrent deflections in the first hours following MCA occlusion. The 2-DG phosphorylation was elevated by 200% in the same area. In contrast, hyperglycemic rats had no, or a single, deflection of the DC potential in the rim, and the 2-DG phosphorylation remained normal. The same pattern was obtained by application of 3 M KCl to the exposed cortex. In normoglycemia potassium application resulted in recurrent deflections of the DC potential, and 2-DG phosphorylation increased in most parts of the hemisphere. Hyperglycemic animals had a nearly stable DC potential, and 2-DG phosphorylation increased only in the tissue area situated directly below the site of potassium application. The results indicate that metabolism in the cortical infarct rim is stimulated by spontaneous and recurrent changes in extracellular potassium--a phenomenon that may be related to spreading depression--and that the metabolism remained normal in the same area in hyperglycemic animals owing to an inhibition of transient increases of extracellular potassium.

Nedergaard, M.; Astrup, J.

1986-10-01

211

Systemic mastocytosis (SM) and associated malignant bone marrow histiocytosis - a hitherto undescribed form of SM-AHNMD.  

UK PubMed Central (United Kingdom)

An elderly woman presented with anaemia, thrombocytopenia and multifocal lytic and sclerotic bone lesions. Trephine bone marrow biopsy demonstrated widespread involvement by systemic mastocytosis (SM). The neoplastic mast cells expressed mast cell tryptase, CD117, CD25 and CD9, and were accompanied by compact sheets of atypical large histiocytic cells, expressing CD68, CD4, S-100 protein and CD14, in keeping with a concomitant histiocytosis (SM-AHNMD). Mutation analysis revealed the activating point mutation D816V of the c-kit proto-oncogene in microdissected pooled bone marrow mast cells. Partial remission was achieved using interferon alpha. To the best of our knowledge this is the first reported case of SM-AHNMD with histiocytosis as the non-mast cell component.

Rudzki Z; Sotlar K; Kudela A; Starzak-Gwó?d? J; Horny HP

2011-01-01

212

Cooking device sealing unit, has sealing material, formed from fluorine-containing material in partial adjustment area, where sealing material has one sealing rim and spring member, which is partly arranged within rim  

UK PubMed Central (United Kingdom)

The unit has a sealing material (28), formed from a fluorine-containing material in a partial adjustment area. The sealing material has a sealing rim and a spring unit, which is partly arranged within the rim for the support during spring-back. The spring units are arranged in a longitudinal extending of the sealing material, where one spring element is implemented with a thick sealing function medium (10). The sealing material has an implementation for acquiring a closing shape.

FISCHER ERICH-OLAF; JOERDENS FRANK; LEBACHER RAINER; ROSENBAUER JOERG; SCHNELL WOLFGANG; WAGNER MICHAEL; PAPST REINHARD

213

Fibrocartilaginous intramedullary bone forming tumor of the distal femur mimicking osteosarcoma.  

UK PubMed Central (United Kingdom)

Fibrocartilaginous dysplasia (FCD) has occasionally led to a misdiagnosis and wrong decision which can significantly alter the outcome of the patients. A 9-yr-old boy presented with pain on his left distal thigh for 6 months without any trauma history. Initial radiographs showed moth eaten both osteolytic and osteosclerotic lesions and biopsy findings showed that the lesion revealed many irregular shaped and sclerotic mature and immature bony trabeculae. Initial diagnostic suggestions were varied from the conventional osteosarcoma to low grade central osteosarcoma or benign intramedullary bone forming lesion, but close observation was done. This study demonstrated a case of unusual fibrocartilaginous intramedullary bone forming tumor mimicking osteosarcoma, so that possible misdiagnosis might be made and unnecessary extensive surgical treatment could be performed. In conclusion, the role of orthopaedic oncologist as a decision maker is very important when the diagnosis is uncertain.

Song SH; Lee H; Song HR; Kim MJ; Park JH

2013-04-01

214

Lincoln's Sign: Where Should We Expect on 99mTc-MDP Bone Scintigraphy?  

Science.gov (United States)

Classical appearance of "Lincoln's sign" on Tc-MDP bone scintigraphy has been described in literature in case of monostotic Paget disease of mandible showing increased radiotracer uptake in the body of mandible. This pattern has also been described as "black beard" sign. The monostotic presentation of Paget disease is rare, and involving the mandible, however, is very unusual. We present a case of carcinoma of the tongue with contiguous spread to the mandible presented in the similar fashion as the earlier reported Lincoln's sign or black beard sign on Tc-MDP bone scintigraphy. This appearance was confirmed with SPECT/CT, and the lytic sclerotic lesion of the mandible was confirmed. PMID:23486327

Bal, Chandra Sekhar; Sahoo, Manas Kumar; Damle, Nishikant

2013-10-01

215

Bone and bone graft healing.  

Science.gov (United States)

Bone is unique in connective tissue healing because it heals entirely by cellular regeneration and the production of a mineral matrix rather than just collagen deposition known as scar. This article discusses the cellular, tissue, and organ levels in each of the following sections--skeletal embryology, normal bone, examples of abnormal bone, and bone graft healing--as they relate to the jaws and the craniofacial skeleton. PMID:18088897

Marx, Robert E

2007-11-01

216

Bone and bone graft healing.  

UK PubMed Central (United Kingdom)

Bone is unique in connective tissue healing because it heals entirely by cellular regeneration and the production of a mineral matrix rather than just collagen deposition known as scar. This article discusses the cellular, tissue, and organ levels in each of the following sections--skeletal embryology, normal bone, examples of abnormal bone, and bone graft healing--as they relate to the jaws and the craniofacial skeleton.

Marx RE

2007-11-01

217

Bilateral Nasal Ala Reconstruction of the Cocaine-Injured Nose with 2 Free Reverse-Flow Helical Rim Flaps.  

UK PubMed Central (United Kingdom)

Cocaine abuse can lead to nasal deformity because of local ischemia and subsequent fibrosis. Reconstruction can be challenging. We present a case of bilateral microsurgical nasal ala reconstruction with 2 reverse-flow helical rim flap.

Castello JR; Taglialatela Scafati S; Sánchez O

2013-04-01

218

PET/MR imaging of bone lesions - implications for PET quantification from imperfect attenuation correction  

International Nuclear Information System (INIS)

Accurate attenuation correction (AC) is essential for quantitative analysis of PET tracer distribution. In MR, the lack of cortical bone signal makes bone segmentation difficult and may require implementation of special sequences. The purpose of this study was to evaluate the need for accurate bone segmentation in MR-based AC for whole-body PET/MR imaging. In 22 patients undergoing sequential PET/CT and 3-T MR imaging, modified CT AC maps were produced by replacing pixels with values of >100 HU, representing mostly bone structures, by pixels with a constant value of 36 HU corresponding to soft tissue, thereby simulating current MR-derived AC maps. A total of 141 FDG-positive osseous lesions and 50 soft-tissue lesions adjacent to bones were evaluated. The mean standardized uptake value (SUVmean) was measured in each lesion in PET images reconstructed once using the standard AC maps and once using the modified AC maps. Subsequently, the errors in lesion tracer uptake for the modified PET images were calculated using the standard PET image as a reference. Substitution of bone by soft tissue values in AC maps resulted in an underestimation of tracer uptake in osseous and soft tissue lesions adjacent to bones of 11.2 ± 5.4 % (range 1.5-30.8 %) and 3.2 ± 1.7 % (range 0.2-4 %), respectively. Analysis of the spine and pelvic osseous lesions revealed a substantial dependence of the error on lesion composition. For predominantly sclerotic spine lesions, the mean underestimation was 15.9 ± 3.4 % (range 9.9-23.5 %) and for osteolytic spine lesions, 7.2 ± 1.7 % (range 4.9-9.3 %), respectively. CT data simulating treating bone as soft tissue as is currently done in MR maps for PET AC leads to a substantial underestimation of tracer uptake in bone lesions and depends on lesion composition, the largest error being seen in sclerotic lesions. Therefore, depiction of cortical bone and other calcified areas in MR AC maps is necessary for accurate quantification of tracer uptake values in PET/MR imaging. (orig.)

2012-01-01

219

PET/MR imaging of bone lesions - implications for PET quantification from imperfect attenuation correction  

Energy Technology Data Exchange (ETDEWEB)

Accurate attenuation correction (AC) is essential for quantitative analysis of PET tracer distribution. In MR, the lack of cortical bone signal makes bone segmentation difficult and may require implementation of special sequences. The purpose of this study was to evaluate the need for accurate bone segmentation in MR-based AC for whole-body PET/MR imaging. In 22 patients undergoing sequential PET/CT and 3-T MR imaging, modified CT AC maps were produced by replacing pixels with values of >100 HU, representing mostly bone structures, by pixels with a constant value of 36 HU corresponding to soft tissue, thereby simulating current MR-derived AC maps. A total of 141 FDG-positive osseous lesions and 50 soft-tissue lesions adjacent to bones were evaluated. The mean standardized uptake value (SUVmean) was measured in each lesion in PET images reconstructed once using the standard AC maps and once using the modified AC maps. Subsequently, the errors in lesion tracer uptake for the modified PET images were calculated using the standard PET image as a reference. Substitution of bone by soft tissue values in AC maps resulted in an underestimation of tracer uptake in osseous and soft tissue lesions adjacent to bones of 11.2 {+-} 5.4 % (range 1.5-30.8 %) and 3.2 {+-} 1.7 % (range 0.2-4 %), respectively. Analysis of the spine and pelvic osseous lesions revealed a substantial dependence of the error on lesion composition. For predominantly sclerotic spine lesions, the mean underestimation was 15.9 {+-} 3.4 % (range 9.9-23.5 %) and for osteolytic spine lesions, 7.2 {+-} 1.7 % (range 4.9-9.3 %), respectively. CT data simulating treating bone as soft tissue as is currently done in MR maps for PET AC leads to a substantial underestimation of tracer uptake in bone lesions and depends on lesion composition, the largest error being seen in sclerotic lesions. Therefore, depiction of cortical bone and other calcified areas in MR AC maps is necessary for accurate quantification of tracer uptake values in PET/MR imaging. (orig.)

Samarin, Andrei [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); University Hospital Zurich, Nuclear Medicine, Zurich (Switzerland); Burger, Cyrill; Crook, David W.; Burger, Irene A.; Schmid, Daniel T.; Schulthess, Gustav K. von; Kuhn, Felix P. [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); Wollenweber, Scott D. [GE Healthcare, Waukesha, WI (United States)

2012-07-15

220

18F-fluoride uptake in bone metastasis. Morphologic and metabolic analysis on integrated PET/CT  

International Nuclear Information System (INIS)

The aim of our study was to evaluate detectability of bone metastatic lesions and evaluate the correlation between 18F-fluoride uptake patterns on positron emission tomography (PET) and morphologic changes on CT using integrated PET/CT. We performed whole-body 18F-fluoride PET/CT staging for 27 patients with known cancer. Tumor types comprised breast (n=7), prostate (n=7), and others (n=13). A total of 154 uptake lesions were evaluated. Both tracer uptake patterns determined by 18F-fluoride PET and morphologic patterns based on CT findings such as morphologic changes, involved locations, and grades scored using five-point scale were compared with histologic tumor subtypes and clinical laboratory data. CT patterns of metastatic lesion were lytic or unclassified in 26 lesions, sclerotic in 53 lesions, and mixed in 75 lesions. Multiple linear regression analysis revealed that metastatic bone lesions with high maximum standardized uptake value (SUVmax) tended to show sclerotic or mixed changes on CT (P18F-fluoride PET/CT. (author)

2010-01-01

 
 
 
 
221

Anterior versus posterior, and rim-rent rotator cuff tears: prevalence and MR sensitivity  

International Nuclear Information System (INIS)

[en] Purpose. To determine the relative distribution of the locations of rotator cuff tears, and the sensitivity of anterior versus posterior tears on MR images. Patients and methods. We identified 110 consecutive patients who had a shoulder MR and either a partial-thickness or a small full-thickness rotator cuff tear diagnosed at arthroscopy. MR sensitivity and patient age were compared between patients with tears in the anterior and posterior halves of the cuff. In addition, in patients with partial tears less than 2 cm in diameter, an age comparison between those with tears in the critical zone and those with articular surface tears adjacent to the bony insertion (rim-rent tear) was performed. Results. The tear was centered in the anterior half of the rotator cuff in 79% of the patients younger than 36 years old, and in 89% of the patients 36 years old and over. The average age of the patients with tears in the anterior half (44 years) was not significantly different from the average age of those with posterior tears (40 years). The sensitivity of MR for anterior tears was 0.69, and for posterior tears it was 0.56. Five of the nine rim-rent tears (0.56) were interpreted correctly on the original MR report; two of the other tears were misinterpreted as intratendinous fluid but were diagnosable in retrospect. Conclusion. Even in patients less than 36 years old, most partial and small full-thickness rotator cuff tears are centered in the anterior half of the supraspinatus. Although our figure for MR sensitivity for these tears is lower than in recent articles, we found no significant difference between the sensitivity of MR for diagnosing posterior tears versus tears in the anterior half of the supraspinatus tendon. Rim-rent tears can be mistaken for intratendinous signal, and should be carefully looked for in younger patients with shoulder pain. (orig.)

1998-01-01

222

Effect of anterior acetabular rim recession on radiographic parameters: an in vivo study.  

UK PubMed Central (United Kingdom)

PURPOSE: The purpose of this study was to validate additional radiographic parameters that detect changes within the acetabular cavity during acetabular rim trimming for pincer-type femoroacetabular impingement in an in vivo setting. METHODS: Patients who met the inclusion criteria and underwent arthroscopic acetabular rim trimming had their preoperative and postoperative anteroposterior radiographs measured. Intraoperatively, these patients had their labrums detached, acetabular walls trimmed by roughly 3 to 5 mm, and then labrums reattached. Radiographic measurements were subsequently obtained by use of the anterior rim angle (ARA), anterior wall angle (AWA), and anterior margin ratio (AMR). RESULTS: Statistically significant changes were seen in the postoperative ARA, AWA, and AMR. Mean pre- and post-trimming changes were 83.8° and 87.9°, respectively, for the ARA; 38.8° and 35.8°, respectively, for the AWA; and 0.57 and 0.53, respectively, for the AMR. There were no postoperative complications. No patients had any instability events. CONCLUSIONS: This study shows that significant changes in anterior acetabular anatomy can be evaluated radiographically in the in vivo setting for treatment of pincer-type femoroacetabular impingement. We saw a significant, consistent decrease in both the AWA and AMR and increase in the ARA. This research serves to guide surgeons with preoperative and intraoperative templating while providing the groundwork to investigate these radiographic parameters in an asymptomatic patient population. CLINICAL RELEVANCE: These novel radiographic measurements can be used by hip arthroscopists to better characterize their surgical role in altering acetabular morphology. In addition, these measurements will be able to better describe acetabular anatomy.

Gross CE; Hellman M; Freedman R; Hart M; Reddy A; Salata M; Bush-Joseph C; Nho SJ

2013-08-01

223

Tumor misto do rim com estrutura de Miosarcoma Mipernefroma e blastema renal em individuo adulto  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O A. descreve um caso de turmor misto do rim, em indivíduo do sexo masculino, com 58 anos de idade. A doença teve evolução lenta, somente sendo suspeitada, quando atingiu a fase final. O exame necroscópico revelou a existência de volumoso tumor do rim direito, apresentando forma bosselada, medindo 19 x 10 x 10 cm e pesando 940 g. A massa tumoral destrói quase completamente a estrutura renal, desta pouca restando reconhecivel. Fora do rim, encontra-se tambem tecido (more) blastomatoso no figado, nos gânglios linfáticos mesentéricos, no peritônio e no epiploon. A estrutura do tumor, observada nos cortes histológicos, é variavel conforme o tecido examinado: no rim hipernefroma; fígado, gãnglios linfáticos, nos nódulos do peritônio e do epiploon, sarcoma mioblástico; em alguns gânglios do mesentério, alem da estrutura de sarcoma mioblástico, existe tecido nefrógeno, representado por formações pouco numerosas, constituidas por túbulos epiteliais, reproduzindo a estrutura de túbulo urinífero. casos desta natureza teem sido referidos com particular raridade, muito se aproximando o caso estudado do descrito por CHEVREL-BODIN e MARUELLE. Abstract in english The A. describes a case of mixed tumor of the kidney in a 58-year-old male individual. The disease underwent a slow evolution, only being suspected when it attained its final stage. The post mortem examination revealed the presence of a bulky tumor of the right kidney, of a bosselated surface, measuring 19 x 10 x 10 cms. and 940 grs. in weigtht. The tumoral mass destroys the whole kidney structure, of which but very little of recognizable tissue is left. Outside the kidne (more) y, blastomatous tissue is also met with in the liver, mesenteric lymphatic glands, peritoneum and apiploon. The tumor structura observed on histological section, varies in conformity with the tissue examined: hipernephroma in the kidney; myoblastic sarcoma in the liver, lymphatic glands, nodules of the peritoneum and epiploon; in some mesenteric glands, apart from the myoblasto-sarcomatous structure, there is nephrogenic tissue, represented by infrequent formations made up epithelial tubules reproducing the structure of uriniferous tubules. Cases of such a feature have been reported as being of particular rarity, and the case here studied approaches very much that described by CHEVREL-BODIN and MARUELLE.

Azevedo, A. Penna de

1942-01-01

224

Tumor misto do rim com estrutura de Miosarcoma Mipernefroma e blastema renal em individuo adulto  

Directory of Open Access Journals (Sweden)

Full Text Available O A. descreve um caso de turmor misto do rim, em indivíduo do sexo masculino, com 58 anos de idade. A doença teve evolução lenta, somente sendo suspeitada, quando atingiu a fase final. O exame necroscópico revelou a existência de volumoso tumor do rim direito, apresentando forma bosselada, medindo 19 x 10 x 10 cm e pesando 940 g. A massa tumoral destrói quase completamente a estrutura renal, desta pouca restando reconhecivel. Fora do rim, encontra-se tambem tecido blastomatoso no figado, nos gânglios linfáticos mesentéricos, no peritônio e no epiploon. A estrutura do tumor, observada nos cortes histológicos, é variavel conforme o tecido examinado: no rim hipernefroma; fígado, gãnglios linfáticos, nos nódulos do peritônio e do epiploon, sarcoma mioblástico; em alguns gânglios do mesentério, alem da estrutura de sarcoma mioblástico, existe tecido nefrógeno, representado por formações pouco numerosas, constituidas por túbulos epiteliais, reproduzindo a estrutura de túbulo urinífero. casos desta natureza teem sido referidos com particular raridade, muito se aproximando o caso estudado do descrito por CHEVREL-BODIN e MARUELLE.The A. describes a case of mixed tumor of the kidney in a 58-year-old male individual. The disease underwent a slow evolution, only being suspected when it attained its final stage. The post mortem examination revealed the presence of a bulky tumor of the right kidney, of a bosselated surface, measuring 19 x 10 x 10 cms. and 940 grs. in weigtht. The tumoral mass destroys the whole kidney structure, of which but very little of recognizable tissue is left. Outside the kidney, blastomatous tissue is also met with in the liver, mesenteric lymphatic glands, peritoneum and apiploon. The tumor structura observed on histological section, varies in conformity with the tissue examined: hipernephroma in the kidney; myoblastic sarcoma in the liver, lymphatic glands, nodules of the peritoneum and epiploon; in some mesenteric glands, apart from the myoblasto-sarcomatous structure, there is nephrogenic tissue, represented by infrequent formations made up epithelial tubules reproducing the structure of uriniferous tubules. Cases of such a feature have been reported as being of particular rarity, and the case here studied approaches very much that described by CHEVREL-BODIN and MARUELLE.

A. Penna de Azevedo

1942-01-01

225

Anterior versus posterior, and rim-rent rotator cuff tears: prevalence and MR sensitivity  

Energy Technology Data Exchange (ETDEWEB)

Purpose. To determine the relative distribution of the locations of rotator cuff tears, and the sensitivity of anterior versus posterior tears on MR images. Patients and methods. We identified 110 consecutive patients who had a shoulder MR and either a partial-thickness or a small full-thickness rotator cuff tear diagnosed at arthroscopy. From the arthroscopy videotapes, we classified the tears as centered in the anterior or posterior half of the cuff, and as either in the critical zone or adjacent to the bony insertion. The original MR interpretation was compared with the arthroscopic findings. MR sensitivity and patient age were compared between patients with tears in the anterior and posterior halves of the cuff. In addition, in patients with partial tears less than 2 cm in diameter, an age comparison between those with tears in the critical zone and those with articular surface tears adjacent to the bony insertion (rim-rent tear) was performed. Results. The tear was centered in the anterior half of the rotator cuff in 79% of the patients younger than 36 years old, and in 89% of the patients 36 years old and over. The average age of the patients with tears in the anterior half (44 years) was not significantly different from the average age of those with posterior tears (40 years)(P=0.23). The sensitivity of MR for anterior tears was 0.69, and for posterior tears it was 0.56 (P=0.17). The average age of the 9 patients with rim-rent tears was 31 years, while that of the 28 patients with similarly-sized partial tears not involving the insertion was 40 years old (P=0.048). Five of the nine rim-rent tears (0.56) were interpreted correctly on the original MR report; two of the other tears were misinterpreted as intratendinous fluid but were diagnosable in retrospect. Conclusion. Even in patients less than 36 years old, most partial and small full-thickness rotator cuff tears are centered in the anterior half of the supraspinatus. Although our figure for MR sensitivity for these tears is lower than in recent articles, we found no significant difference between the sensitivity of MR for diagnosing posterior tears versus tears in the anterior half of the supraspinatus tendon. Rim-rent tears can be mistaken for intratendinous signal, and should be carefully looked for in younger patients with shoulder pain. (orig.) With 5 figs., 2 tabs., 19 refs.

Tuite, M.J.; Turnbull, J.R.; Orwin, J.F. [Wisconsin Univ., Madison, WI (United States). Dept. of Radiology

1998-05-01

226

Focal lamina cribrosa defects associated with glaucomatous rim thinning and acquired pits.  

UK PubMed Central (United Kingdom)

IMPORTANCE: Considering the potential clinical importance of focal lamina cribrosa (LC) defects as a characteristic structural feature in glaucoma and a risk factor for glaucomatous visual field progression, it may be helpful to know the structure of focal LC defects and the spatial relationship between them and glaucomatous optic disc changes such as neuroretinal rim thinning/notching and acquired pits of the optic nerve (APON). OBJECTIVE: To investigate structural and spatial relationships between focal LC defects and glaucomatous neuroretinal rim thinning/notching and APON. DESIGN: In a cross-sectional analysis of data from an ongoing, prospective, longitudinal study, serial enhanced-depth imaging (EDI) optical coherence tomographic (OCT) images of the optic nerve head were obtained from patients with glaucoma and reviewed for focal LC defects (laminar holes or disinsertions). Anterior laminar insertion points and edges of laminar holes or disinsertions were marked in EDI-OCT images, reconstructed 3-dimensionally, and superimposed on optic disc photographs. SETTING: A glaucoma referral practice. PARTICIPANTS: Two hundred thirty-nine eyes (120 patients) were examined. Fifty-four eyes were excluded because of an incomplete horizontal or vertical set of serial EDI-OCT images or poor-quality EDI-OCT images owing to media opacity, irregular tear film, or poor patient cooperation. Among the remaining 185 eyes, 40 (from 31 patients) had laminar holes or disinsertions and were included for analysis. MAIN OUTCOME MEASURES: Presence, extent, and location of laminar holes or disinsertions. RESULTS: Among 185 eyes, 11 laminar holes and 36 laminar disinsertions were found in 40 eyes. Superimposed images of the 3-dimensionally reconstructed focal LC defects and disc photographs showed that the outline of the LC defect corresponded almost precisely to that of clinical APON for 6 laminar holes and that the LC defect was much larger than and enclosed APON for 10 laminar disinsertions. The remaining 5 laminar holes and 26 laminar disinsertions corresponded to focal neuroretinal rim loss, with no evidence of APON in disc photographs. CONCLUSIONS AND RELEVANCE: Focal LC defects (laminar holes or disinsertions) are associated with neuroretinal rim loss and APON. The extent of LC defects can be visualized more effectively on EDI-OCT images than by clinical examination.

You JY; Park SC; Su D; Teng CC; Liebmann JM; Ritch R

2013-03-01

227

Radioisotopic measurement methods for determining the wear railway brake shoe and its rim wearing effect  

International Nuclear Information System (INIS)

Under operating conditions the wear of brake shoe was tested by a measuring method based on the principle of radioisotopic thickness measurement. It is characteristic to the sensitivity of the method that the wear caused by the fast braking of a train (speed: 100 km/h) as well as the uneven wear distribution were determinable. Surface activating methods assuring the periodic and continuous evaluation were also developed. A test was performed with galvanic surface activation under operating conditions to determine the rim wearing effect of the brake shoe. Apart from the operational tests a new method based on activated wear measurement was also developed. (author).

1979-01-01

228

Notes on the uwainat oil rim development, Maydan Mahzam and Bul Hanine Fields, offshore Qatar  

Energy Technology Data Exchange (ETDEWEB)

As a result of reservoir simulation studies of the Uwainat reservoirs (Maydan Mahzam and Bul Hanine Fields), drilling to the Uwainat oil rim target became very ''tight'' with a very limited vertical tolerance. To achieve drilling to the tight target requires a precise position of the well at the top of the Lower Arab IV reservoir (a reliable marker) and an accurate isochore of the Lower Arab IV - Uwainat. The discussion shows that the level of accuracy needed in determining both the actual subsea well position and in constructing the depth contours of the reservoirs is extremely high.

Hamam, K.A.

1985-03-01

229

Bone imaging  

International Nuclear Information System (INIS)

The ease of preparation of such radiopharmaceuticals which deliver a low total body radiation dose has revolutionized bone scanning and has relegated 85Sr and comparable agents to the past history of bone imaging. The search for elements which were metabolically similar to calcium in their uptake in the bone hydroxyapatite crystal has been abandoned in favor of a more empirical approach which exploits the nearly ideal physical and chemical properties of /sup 99m/Technetium. This radionuclide forms complexes with multiple compounds. It is labeled to phosphorus containing molecules to form a bone-seeking radiopharmaceutical which may give superior images of bony anatomy

1975-01-01

230

Study on thd relationship between serum fibrosis markers levels, bone marrow scintigraphy patterns and clinical staging in patients with chronic ldiopathic myelofibrosis (CIMF)  

International Nuclear Information System (INIS)

Objective: To study the changes of serum fibrosis markers levels and the pattern of bone marrow scintigraphy and their relationship with clinical stages in patients with chronic idiopathic myelofibrosis (CIMF). Methods: Transforming growth factor-?1 (TGF-?1) and platelet derived growth factor (PDGF) (with ELISA), serum typeIII procollagen (PCIII), type IV collagen (C-IV), and laminin (LN) (with RIA) were detected in 46 with patients with chronic idiopathic myelofibrosis and 34 controls. Bone marrow scintigraphy 99m Tc-sulfur colloid was performed in the 46 CIMF patients. Results: Five fibrosis markers in patients with CIMF were significantly higher than those in controls. There were significantly differences among the levels in different stages, especially with sclerotic stage in CIMF patients. The imaging patterns were classified into three types according to the radio-distribution and activity of bone marrow: 13 cases of increased imaging in 14 patients of cellular stage, 17 cases with creased expansion imaging in 19 patients of collagen fiber stage and 13 cases (100%) with totally depressed imaging in patients of sclerotic stage. Conclusion: As the disease progressed, the serum fibrosis markers levels gradually incroased and the scintigraphy patterns corresponded well to the clinical staging. (authors)

2009-01-01

231

Bone Metastasis  

International Nuclear Information System (INIS)

In this paper we revised the fundamental data concerning bonemetastasis, its incidence and distribution, and the diagnostic procedures. Otherwise, we summarize the pathogenetic features related with bone metastasis, both osteoblastic and osteolytic lesions. We enfatize aboutlocal and general factors involved in bone metastasis production. Humoral factors are revised and direct or indirect mediators are signaled. (Author) 36 refs.

1996-01-01

232

Analysis of physical processes affecting restructuring of UO2 fuel in Rim-zone  

International Nuclear Information System (INIS)

The purpose of the presented paper is the analysis of the processes affecting so-called 'rim-zone' formation in UO2 and the development of the model describing isotope content profiles at extended burnup. The influence of rim-zone and extended burnup on fuel temperatures is also considered. A brief review of the worldwide models for fission rate and isotope content profiles at extended burnup is given. In this frame, a new model for for prediction of radial profiles of burnup, fission rate and plutonium isotopes have been developed in the TRINITY (Russia). The results from the comparison of the model predictions with experimental data show that the model has good predictability. A new model describing the conditions of dislocation loop nucleation from interstitial atom clusters on fission spikes is also proposed in this paper. The results of the model show that the fuel grain diameter significantly affects the concentration of point defects and dislocation loops. The paper presents the results from the RTOP code calculations of fuel temperature, taking into account non-uniform fission rate and thermal conductivity degradation as result of burnup increasing

2001-01-01

233

Modeling Eclipses in the Classical Nova V Persei: The Role of the Accretion Disk Rim  

CERN Multimedia

Multicolor (BVRI) light curves of the eclipsing classical nova V Per are presented, and a total of twelve new eclipse timings have been measured for the system. When combined with previous eclipse timings from the literature, these timings yield a revised ephemeris for the times of mid-eclipse given by HJD = 2,447,442.8620(1) + 0.107123474(3) E. The eclipse profiles have been analyzed with a parameter-fitting model that assumes four sources of luminosity: a white dwarf primary star, a main-sequence secondary star, a flared accretion disk with a rim, and a bright spot at the intersection of the mass transfer stream and the disk periphery. A matrix of model solutions have been computed, covering an extensive range of plausible parameter values. The solution matrix was then explored to determine the optimum values for the fitting parameters and their associated errors. For models that treat the accretion disk as a flat structure without a rim, optimum fits require that the disk have a flat temperature profile. A...

Shafter, A W

2006-01-01

234

Definition imaging of an orebody with the radio imaging method (RIM)  

Energy Technology Data Exchange (ETDEWEB)

Waste rock dilution is an economic concern in the planning and design of mining methods for mineralized ore zones. Diamond core drilling and mineralogical examination of core are routinely used to determine the general shape of the ore body. Drilling on closer centers enhances the definition of the mineralization and oregrade across the orebody. In a practical sense, drilling time and cost limit definition. Crosshole scanning between drillholes with the radio imaging method (RIM) has been used to map changes in mineralization in the rock mass. The magnitude and phase of the RIM radio wave depend on the electrical conductivity of the rock mass. The conductivity strongly depends on the percent mineralization. Since the attenuation rate and phase constants of the radio wave are proportional to the one half power of conductivity, the measured crosshole radio wave data can be processed in a tomography algorithm to reconstruct images (map the change in conductivity (mineralization)). The tomography image enhances definition in the orebody while reducing the number of drillholes. This paper compares reconstructed images of the radio wave propagation constants to percent mineralization in the ore body.

Stolarczyk, L.G. (Stolar, Inc., Raton, NM (United States))

1992-10-01

235

Definition imaging of an orebody with the radio imaging method (RIM)  

International Nuclear Information System (INIS)

Waste rock dilution is an economic concern in the planning and design of mining methods for mineralized ore zones. Diamond core drilling and mineralogical examination of core are routinely used to determine the general shape of the ore body. Drilling on closer centers enhances the definition of the mineralization and oregrade across the orebody. In a practical sense, drilling time and cost limit definition. Crosshole scanning between drillholes with the radio imaging method (RIM) has been used to map changes in mineralization in the rock mass. The magnitude and phase of the RIM radio wave depend on the electrical conductivity of the rock mass. The conductivity strongly depends on the percent mineralization. Since the attenuation rate and phase constants of the radio wave are proportional to the one half power of conductivity, the measured crosshole radio wave data can be processed in a tomography algorithm to reconstruct images (map the change in conductivity (mineralization)). The tomography image enhances definition in the orebody while reducing the number of drillholes. This paper compares reconstructed images of the radio wave propagation constants to percent mineralization in the ore body

1992-01-01

236

Nonthermal emission properties of the northwestern rim of supernova remnant RX J0852-4622  

CERN Document Server

The supernova remnant (SNR) RX J0852-4622 (Vela Jr., G266.6-1.2) is one of the most important SNRs for investigating the acceleration of multi-TeV particles and the origin of Galactic cosmic rays because of its strong synchrotron X-ray and TeV gamma-ray emission, which show a shell-like morphology similar to each other. Using the XMM-Newton archival data consisting of multiple pointing observations of the northwestern rim of the remnant, we investigate the spatial properties of the nonthermal X-ray emission as a function of distance from an outer shock wave. All X-ray spectra are well reproduced by an absorbed power-law model above 2 keV. It is found that the spectra show gradual softening from a photon index 2.56 in the rim region to 2.96 in the interior region. We show that this radial profile can be interpreted as a gradual decrease of the cutoff energy of the electron spectrum due to synchrotron cooling. By using a simple spectral evolution model that includes continuous synchrotron losses, the spectral s...

Kishishita, Tetsuichi; Uchiyama, Yasunobu

2013-01-01

237

Mini-RIMS: a miniature roll-stabilized inertial measurement system  

Energy Technology Data Exchange (ETDEWEB)

High-performance spinning-flight vehicle have always presented a difficult set of requirements for inertial measurement systems (IMSs). These requirements typically include high levels of vibration and shock, as well as high levels of acceleration and angular rate. In addition, the increasing complexity and size of payloads in these vehicles leave less volume and weight available for the IMS. The Mini-RIMS inertial measurement system offers a solution to these problems. The Mini-RIMS is composed of two major assemblies: an inertial platform assembly and an electronic assembly. The platform assembly consists of a single-axis platform containing gyroscopes and accelerometers oriented so that angular velocity and linear acceleration are sensed about or along three orthogonal axes: roll, pitch, and yaw. The platform can either be pinned to the base so that it moves with the host vehicle or stabilized about its roll axis. In the first case, an inertial strapdown mode is implemented about all three axes. In the second case, the roll axis is decouple from roll motions of the vehicle while the pitch and yaw axes continue to be instrumented in strapdown fashion.

Imbault, J.J.; Tjulin, H.; Kinney, R.; Kohler, S.

1986-01-01

238

The Pacific Rim and global natural gas. [Trends in production and consumption  

Energy Technology Data Exchange (ETDEWEB)

There is a growing interest in natural gas as a part of national or international strategies to moderate the environmental consequences of fuel use. Although the underutilized global gas resource justifies the interest, the future consumption of gas is likely to be constrained by the high capital costs of new transportation facilities to bring remote gas supplies into areas of growing energy demand. The Asian Pacific Rim countries include rapidly growing demand areas as well as significant reserves of gas. The region will continue to play a leading role in the evolution of a world trade in gas. Gas resources within the Asian Pacific region are adequate to serve the foreseeable demands, but historically the region has utilized liquefied natural gas (LNG) imports. Financial constraints upon the gas producing countries of the region and political instability in some of them will probably continue to require the importing of sustantial quantities of gas from the Middle East and possibly from Alaska and the former USSR as the resources indigenous to the region itself are developed more slowly than demand. The financial arrangements and contractual approaches that evolve to meet the needs of the Asia Pacific Rim will shape the future of world LNG markets. (Author)

Dreyfus, D.A. (Gas Research Inst., Washington, DC (United States). Strategic Analysis and Energy Forecasting Div.)

1993-02-01

239

The three-dimensional relationship between acetabular rim morphology and the severity of femoral cam lesions.  

UK PubMed Central (United Kingdom)

We examined the relationship between the size of the femoral cam in femoroacetabular impingement (FAI) and acetabular pathomorphology to establish if pincer impingement exists in patients with a femoral cam. CT scans of 37 symptomatic impinging hips with a femoral cam were analysed in a three-dimensional study and were compared with 34 normal hips. The inclination and version of the acetabulum as well as the acetabular rim angle and the bony acetabular coverage were calculated. These measurements were correlated with the size and shape of the femoral cams. While the size of the femoral cam varied characteristically, the acetabular morphology of the two groups was similar in terms of version (normal mean 23° (sd 7°); cam mean 22° (sd 9°)), inclination (normal mean 57° (sd 5°); cam mean 56° (sd 5°)), acetabular coverage (normal mean 41% (sd 5%); cam mean 42% (sd 4%)) and the mean acetabular rim angle (normal mean 82° (sd 5°); cam mean 83° (sd 4°)). We found no correlation between acetabular morphology and the severity of cam lesion and no evidence of either global or focal over-coverage to support the diagnosis of 'mixed' FAI. The femoral cam may provoke edge loading but removal of any acetabular bearing surface when treating cam FAI might induce accelerated wear.

Masjedi M; Nightingale CL; Azimi DY; Cobb JP

2013-03-01

240

The GT-MHR - clear, economic, and safe power for the Pacific Rim  

International Nuclear Information System (INIS)

In recent decades the nations of the Pacific Rim have outpaced the rest of the world in economic growth. Beyond an abundant labor market and the region's natural resources, energy has played a pivotal role in fuelling this boom. The diverse sources of this energy largely reflect the naturally occurring fuel assets in the Rim countries. Only in the countries where these resources are less plentiful has nuclear energy become a significant sources of electric power generation. Persuasive as the argument for non-polluting power may be by itself it does not sell the nuclear energy option. In addition to being clean it must also be economically competitive and very safe. The authors claim that the Gas-Turbine Modular Helium Reactor (GT-MHR) is an advances nuclear power system that addresses the issues, and should be viewed as an attractive candidate to meet future energy needs. The GT-MHR derives from the coupling of a small, passively safe, modular reactor directly with a compact power conversion module. It uses the Brayton cycle to produce electricity directly with the primary helium coolant driving the turbine-generator. Thus, it shows promise for a quantum reduction in power generation costs by increasing plant efficiency to a remarkable 48% This paper highlights the advantages of the fact that the design is based on proven technology, and offers a clean, economic and safe energy for electricity and high temperature process heat. 2 refs., 4 figs.

1994-01-01

 
 
 
 
241

Ablation of high-temperature superconductor studied by resonance ionization mass spectrometry (RIMS)  

Energy Technology Data Exchange (ETDEWEB)

Laser ablation of bulk high-temperature superconductor (HTS) material provides a useful means of producing high-quality HTS thin films. Mass spectrometric probes of the ablation plume provide a microscopic understanding of the ablation event and plume development as well as providing a process monitor for the thin-film production. Resonance ionization mass spectrometry (RIMS) detection of the ablated neutral species supplies valuable physical information about the ablation event necessary for developing models of the process. Time-of-flight/RIMS detection of Cu, Y, and BaO ablated from YBa{sub 2}Cu{sub 3}O{sub 7{minus}{ital x}} indicates the ablation involves post-desorption gas phase collisions, which influence the ablation chemistry and dynamics (e.g., angular and velocity distributions). Approximately equal velocities are observed for all neutral species at constant ablation laser fluence. In addition, BaO exhibits a rotational temperature far less than the directed translational temperature.

Estler, R.C.; Nogar, N.S. (Chemical and Laser Sciences Division, MS G 738 Los Alamos National Laboratory, Los Alamos, NM (USA))

1991-02-01

242

Evaluation of Progressive Neuroretinal Rim Loss as a Surrogate End Point for Development of Visual Field Loss in Glaucoma.  

UK PubMed Central (United Kingdom)

PURPOSE: To evaluate the validity of using progressive loss of neuroretinal rim area as a surrogate end point for the development of visual field loss in glaucoma. DESIGN: Prospective, observational cohort study. PARTICIPANTS: The study group included 492 eyes of 328 patients classified with suspected glaucoma at the baseline visit. These eyes had an average of 7.4±2.8 confocal scanning laser ophthalmoscopy (CSLO) images during a mean follow-up time of 6.6±1.6 years. METHODS: Rim area measurements were acquired with CSLO during follow-up. The visual field end point was considered the development of 3 consecutive abnormal visual fields on standard automated perimetry. Strong predictive ability and large proportion of treatment effect (PTE) explained are requisites for a suitable surrogate end point. A joint longitudinal survival model was used to evaluate the ability of rates of rim area loss in predicting visual field development, adjusting for confounding variables (baseline age, race, and corneal thickness and follow-up measurements of intraocular pressure [IOP] and pattern standard deviation). The PTE was calculated by comparing the effect of IOP on the risk of development of visual field loss when incorporating rim area loss in the same model with the effect of IOP in the model excluding rim area measurements. MAIN OUTCOME MEASURES: Predictive strength was measured by survival-adapted R(2) and PTE. RESULTS: Sixty-two of 492 eyes (13%) developed visual field loss during follow-up. The mean rate of rim area change in eyes that developed visual field loss was -0.011 mm(2)/year versus -0.003 mm(2)/year in eyes that did not (P<0.001). In the multivariable model, each 0.01 mm(2)/year faster rate of rim area loss was associated with a 2.94 higher risk of visual field loss (hazard ratio, 2.94; 95% confidence interval, 1.38-6.23; P = 0.005). R(2) values were 62% and 81% for univariable and multivariable models, respectively. The PTE was 65%. CONCLUSIONS: Progressive rim area loss was highly predictive of the development of visual field loss in glaucoma and explained a significant PTE on the clinically relevant outcome. These findings suggest that rim area measurements may be suitable surrogate end points in glaucoma clinical trials. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.

Medeiros FA; Lisboa R; Zangwill LM; Liebmann JM; Girkin CA; Bowd C; Weinreb RN

2013-08-01

243

Effect of head contact on the rim of the cup on the offset loading and torque in hip joint replacement.  

UK PubMed Central (United Kingdom)

Head contact on the rim of the cup causes stress concentration and consequently increased wear. The head contact on the rim of the cup may in addition cause an offset load and torque on the cup. The head-rim contact resulting from microseparation or subluxation has been investigated. An analytical model has been developed to calculate the offset loading and resultant torque on the cup as a function of the translational displacement of the head under simplified loading condition of the hip joint at heel strike during a walking cycle. The magnitude of the torque on the cup was found to increase with the increasing translational displacement, larger diameter heads, eccentric cups, and the coefficient of friction of the contact. The effects of cup inclination, cup rim radius, and cup coverage angle on the magnitude of the torque were found to be relatively small with a maximum variation in the torque magnitude being lower than 20%. This study has shown an increased torque due to the head loading on the rim of the cup, and this may contribute to the incidence of cup loosening. Particularly, metal-on-metal hip joints with larger head diameters may produce the highest offset loading torque.

Liu F; Williams S; Jin Z; Fisher J

2013-07-01

244

[Importance of 3T3 feeder layer to establish epithelial cultures from cell suspension obtained from corneo-scleral rims].  

UK PubMed Central (United Kingdom)

PURPOSE: To evaluate the importance of the presence of 3T3 fibroblasts for establishing limbal epithelial cultures from cell suspension obtained from corneo-scleral rims (CSR). METHODS: Corneo-scleral rims from different donors (n=6) had their posterior stroma and endothelium stripped away. Each corneo-scleral rim was divided into three equal segments that were set up in tissue culture in three different conditions: one of the segments was placed with the epithelial side up on the bottom of a 6-well culture plate (Group A). The other two fragments were trypsinized and the obtained cell suspension was cultured with (Group B) or without (Group C) irradiaded 3T3 cells. The cells were cultured in supplemental hormonal epithelial medium (SHEM), the epithelial migration and clone formation in groups A, B and C were evaluated with phase contrast microscopy and rodamine B staining. RESULTS: Epithelial cell growth was observed in 4/6 rims (Group A). All epithelial cell suspensions that were cultured with 3T3 cells (Group B) formed clones. No adhesion or true clone formation (holo- or meroclones) was observed in the cell suspensions that were cultivated without 3T3 (Group C) (p=0.009). CONCLUSIONS: Epithelial cell suspension obtained from corneo-scleral rims in this model needs to be cultivated with 3T3 cells in order to form clones and establish limbal epithelial cell colonies with the potential to be used for ocular surface reconstruction.

Cristovam PC; Glória MA; Melo GB; Gomes JA

2008-09-01

245

Stereological evolution of the rim structure in PWR-fuels at prolonged irradiation: Dependencies with burn-up and temperature  

Energy Technology Data Exchange (ETDEWEB)

The stereology of the rim-structure was studied for PWR-fuels up to the ninth irradiation cycle, achieving maximum local burn-ups of 240 GWd/tM and beyond. At intermediate radial positions (0.55 < r/r {sub 0} < 0.7), a small increase of the pore and grain size of recrystallized areas was found, which is attributed to the increase of the irradiation temperatures in the outer half-pellet-radius due to deterioration of the thermal conductivity. In the rim-zone marked pore coarsening and pore-density-drop occur on surpassing the local burn-up of 100 GWd/tM, associated with cavity fractions of {approx}0.1. Above this threshold the porosity growth rate drops and stabilizes at a value nearing the matrix-gas swelling-rate ({approx}0.6%/10 GWd/tM). The rim-cavity coarsening shows ingredients of both Ostwald-ripening and coalescence mechanisms. Despite individual pore-contact events, no clusters of interconnected pores were observed up to maximum pore fractions checked ({approx}0.24). The rim-pore-structure is found to be well represented in its lower bound by the model system of random penetrable spheres, with percolation threshold at {phi} {sub c} = 0.29. Rim-cavities are expected to remain closed at least up to this limit.

Spino, J. [European Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, D-76125 Karlsruhe (Germany)]. E-mail: jose.spino@itu.fzk.de; Stalios, A.D. [European Commission, DG RTD, Industrial Technologies-Materials, CDMA 00/168, Rue du Champ de Mars 21, B-1049 Brussels (Belgium); Santa Cruz, H. [European Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, D-76125 Karlsruhe (Germany); Baron, D. [Electricite de France (EDF), Research and Development, CEA Cadarache, DEC/SESC, 13108 Saint-Paul-Lez-Durance cedex (France)

2006-08-01

246

68Ga-DOTA-NOC PET/CT in comparison with CT for the detection of bone metastasis in patients with neuroendocrine tumours  

International Nuclear Information System (INIS)

To retrospectively evaluate the sensitivity, specificity and accuracy of 68Ga-DOTA-NOC PET/CT and CT alone for the evaluation of bone metastasis in patients with neuroendocrine tumour (NET). From among patients with NET who underwent 68Ga-DOTA-NOC PET/CT between April 2006 and November 2008 in our centre, 223 were included in the study. Criteria for inclusion were pathological confirmation of NET and a follow-up period of at least 10 months. PET and CT images were retrospectively reviewed by two nuclear medicine specialists and two radiologists, respectively, without knowledge of the patient history or the findings of other imaging modalities. PET data were compared with the CT findings. Interobserver agreement was evaluated in terms of the kappa score. Clinical and imaging follow-up were used as the standard of reference to evaluate the PET findings. PET was performed for staging (49/223), unknown primary tumour detection (24/223), restaging (32/223), restaging before radioimmunotherapy (1/223), evaluation during therapy (12/223), equivocal findings on conventional imaging (4/223 at the bone level; 61/223 at sites other than bone), and follow-up (40/223). A very high interobserver agreement was observed. CT detected at least one bone lesion in only 35 of 44 patients with a positive PET scan. In particular, PET showed more lesions in 20/35 patients, a lower number of lesions in 8/35, and the same number in 7/35. The characteristics of the lesions (sclerotic, lytic, mixed) on the basis of the CT report did not influence PET reading. PET revealed the presence of at least one bone metastasis in nine patients with a negative CT scan. Considering patients with a negative PET scan (179), CT showed equivocal findings at the bone level in three (single small sclerotic abnormality in two at the spine level, and bilateral small sclerotic abnormalities in the humeri, femurs and scapula). Clinical follow-up confirmed the PET findings in all patients; thus there were no false-positive or false-negative findings. Considering all patients, PET detected more lesions than CT (246 vs. 194). As compared to CT, on a patient basis PET showed a higher sensitivity (100% vs. 80%), specificity (100% vs. 98%), positive predictive value (100% vs. 92%), and negative predictive value (100% vs. 95%). In conclusion, 68Ga DOTA-NOC PET was more accurate than CT for the identification of bone lesions and led to a change in clinical management in nine patients with a negative CT scan. (orig.)

2010-01-01

247

Fine-grained rims surrounding chondrules in the Tagish Lake carbonaceous chondrite: Verification of their formation through parent-body processes  

Science.gov (United States)

A petrographic and electron microscopic study of the carbonate-poor lithology of the Tagish Lake carbonaceous chondrite reveals that most chondrules contain many pseudomorphs of opaque nodules and are surrounded by phyllosilicate-rich altered zones that were formed by replacing enstatite and opaque nodules along the chondrule peripheries. Most chondrules and other coarse-grained components are surrounded by fine-grained rims, which are commonly disaggregated and partly lacking. The altered zones and the rims are compositionally and texturally similar, although they exhibit some differences in secondary minerals. In comparison, the rims and the host matrix show more significant differences in bulk chemical composition, texture, and mineralogy. The observations suggest that the chondrules and the rims experienced aqueous alteration simultaneously, whereas the rims and the matrix experienced aqueous alteration under distinct conditions. We also found a clast that contains multiple coarse-grained components embedded in a matrix and numerous smaller matrix clasts. The coarse-grained components in the clast have no rims, and the matrices of the clasts are mineralogically identical to the rims.The results suggest that the chondrules, other coarse-grained components, and their rims (generically referred to as chondrules/rims) and the clasts originated from a common precursor region in the meteorite parent-body that was different from the location where the host meteorite was finally lithified. That is, the chondrules/rims are actually clasts produced by brecciation and later transported and incorporated into the present host matrix. The rims are, therefore, remnants of matrix material that formerly filled interspaces between the chondrules and other coarse-grained components. This model is essentially consistent with those previously proposed for the carbonate-rich lithology of Tagish Lake and the hydrated chondrules/rims in the Vigarano and Mokoia CV3 chondrites.

Takayama, Akiko; Tomeoka, Kazushige

2012-12-01

248

Bone metastases in medulloblastoma--single institution experience.  

UK PubMed Central (United Kingdom)

BACKGROUND: Medulloblastoma has one of the highest rates of metastasis outside the central nervous system (CNS). Bone metastases are the most common lesions, although lymph node and visceral spread have also been reported. OBJECTIVE: To present patients with bone metastasis in medulloblastoma and discuss their radiologic appearances and treatment approach. PATIENTS AND METHODS: From 1993 to 2008, 82 patients diagnosed with medulloblastoma were treated at the Institute for Oncology and Radiology of Serbia. Three (3.6%) developed extraneural metastasis (ENM). In primary treatment, patients were treated with surgery, craniospinal radiotherapy with local boost to tumor bed, and adjuvant chemotherapy [lomustine (CCNU) and vincristine]. Of the three patients with ENM, all developed bone metastases at the time of relapse. Relapse occurred within 17 to 42 months of initial diagnosis. Patients received secondary chemotherapy and palliative radiotherapy to the affected bone in two cases. RESULTS: Among these three patients, case 1 had initially a solitary lytic lesion. Case 2 had diffuse blastic lesions and also bone marrow involvement. Case 3 had multiple mixed lytic-sclerotic lesions but later developed lymph node metastasis and metastases to both breasts, as well. All patients were without concurrent CNS involvement at the time of ENM. Unfortunately, after initial partial response, the three patients died at 24, 13, and 18 months after detection of metastases, respectively. CONCLUSION: With prolonged survival times in children with medulloblastoma, more emphasis should be placed on the possibility of systemic involvement. A greater understanding of the pathogenesis of the systemic metastases may be valuable in designing future, more aggressive multimodal therapy.

Nikitovi? M; Bokun J; Paripovi? L; Golubi?i? I; Gruji?i? D; Sopta J

2013-03-01

249

Rim structure formation of large-grained UO{sub 2} fuels irradiated in the Halden heavy water reactor  

Energy Technology Data Exchange (ETDEWEB)

Irradiation-induced fuel microstructural evolution of the sub-divided grain structure, or rim structure, of large-grained UO{sub 2} pellets has been examined through detailed PIEs by OM, SEM, TEM and EPMA. Besides standard grain size pellets with a grain size range of 9-12 {mu}m, two types of undoped and alumino-silicate doped large-grained pellets with a range of 37-63 {mu}m were irradiated in the Halden heavy water reactor to rod average burnups of 25-75 GWd/t The effect of grain size on the rim structure formation was quantitatively evaluated in terms of the average Xe depression in the pellet outside region measured by EPMA, based on its lower sensitivity for Xe enclosed in the coarsened rim bubbles (author) (ml)

Une, K.; Hirai, M.; Nogita, K.; Hosokawa, T.; Suzawa, Y.; Shimizu, S.; Etoh, Y.

1999-05-15

250

Three-dimensional microstructural analysis of human lumber vertebrae using microcomputed tomography in bone metastasis from prostate cancer  

Energy Technology Data Exchange (ETDEWEB)

Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. However, the morphological details of bone metastasis of prostate cancer have not been clarified. The trabecular bone structure of bone metastasis from prostate cancer was investigated in three dimensions using microcomputed tomography (micro-CT). A total of 17 cubes of the lumber spine of a 77-year-old man with prostate cancer were excised post mortem: four of them from non-metastatic and the rest from metastatic sites. The samples were measured using micro-CT with a resolution of 23.2 {mu}m and the standard structural indices and degree of anisotropy were computed. After micro-CT measurement, the samples were tested in a destructive manner for the assessment of mechanical properties. Samples from the metastatic sites showed significantly higher values than those from non-metastatic sites for bone volume (BV), bone surface (BS), bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N) (p<0.005). Bone surface density (BS/BV) and trabecular separation (Tb.Sp) were significantly higher in the samples from non-metastatic sites (p<0.001). Samples from metastatic sites showed a more isotropic arrangement of trabecular bone than those from non-metastatic sites. Three-dimensionally reconstructed images depicted several different patterns of sclerotic bone metastasis, and osteolytic appearance was observed in all of them. Structural parameters such as BV/TV were well correlated with the mechanical properties (r=0.899). The present study clarified the trabecular microstructure of bone metastasis from prostate cancer and suggests that both osteolysis and osteogenesis progress while interacting with each other in all phases of bone metastasis. (author)

Tamada, Tsutomu [Kawasaki Medical School, Kurashiki, Okayama (Japan)

2000-11-01

251

Bone cancer.  

UK PubMed Central (United Kingdom)

Primary bone cancers are extremely rare neoplasms, accounting for fewer than 0.2% of all cancers. The evaluation and treatment of patients with bone cancers requires a multidisciplinary team of physicians, including musculoskeletal, medical, and radiation oncologists, and surgeons and radiologists with demonstrated expertise in the management of these tumors. Long-term surveillance and follow-up are necessary for the management of treatment late effects related to surgery, radiation therapy, and chemotherapy. These guidelines discuss the management of chordoma, giant cell tumor of the bone, and osteosarcoma.

Biermann JS; Adkins DR; Agulnik M; Benjamin RS; Brigman B; Butrynski JE; Cheong D; Chow W; Curry WT; Frassica DA; Frassica FJ; Hande KR; Hornicek FJ; Jones RL; Mayerson J; McGarry SV; McGrath B; Morris CD; O'Donnell RJ; Randall RL; Santana VM; Satcher RL; Siegel HJ; von Mehren M; Bergman MA; Sundar H

2013-06-01

252

Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses.  

UK PubMed Central (United Kingdom)

UNLABELLED: Infectious microorganisms often play a role in modulating the immune responses of their infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 transcription factor to regulate cell wall composition and the host-pathogen interface. In the absence of Rim101, C. neoformans exhibits an altered cell surface in response to host signals, generating an excessive and ineffective immune response that results in accelerated host death. This host immune response to the rim101? mutant strain is characterized by increased neutrophil influx into the infected lungs and an altered pattern of host cytokine expression compared to the response to wild-type cryptococcal infection. To identify genes associated with the observed phenotypes, we performed whole-genome RNA sequencing experiments under capsule-inducing conditions. We defined the downstream regulon of the Rim101 transcription factor and determined potential cell wall processes involved in the capsule attachment defects and altered mechanisms of virulence in the rim101? mutant. The cell wall generates structural stability for the cell and allows the attachment of surface molecules such as capsule polysaccharides. In turn, the capsule provides an effective mask for the immunogenic cell wall, shielding it from recognition by the host immune system. IMPORTANCE: Cryptococcus neoformans is an opportunistic human pathogen that is a significant cause of death in immunocompromised individuals. There are two major causes of death due to this pathogen: meningitis due to uncontrolled fungal proliferation in the brain in the face of a weakened immune system and immune reconstitution inflammatory syndrome characterized by an overactive immune response to subclinical levels of the pathogen. In this study, we examined how C. neoformans uses the conserved Rim101 transcription factor to specifically remodel the host-pathogen interface, thus regulating the host immune response. These studies explored the complex ways in which successful microbial pathogens induce phenotypes that ensure their own survival while simultaneously controlling the nature and degree of the associated host response.

O'Meara TR; Holmer SM; Selvig K; Dietrich F; Alspaugh JA

2013-01-01

253

Modelo de tumor experimental em rim de ratos Experimental tumor model in rats kidney  

Directory of Open Access Journals (Sweden)

Full Text Available O carcinossarcoma 256 de Walker tem despertado o interesse de muitos pesquisadores como modelo experimental para estudo da biologia tumoral. OBJETIVO: estabelecer um modelo de tumor renal que possa ser usado para estudar in vivo e in vitro, as alterações impostas pelas neoplasias. MÉTODOS: utilizados vinte ratos Wistar, machos, adultos, pesando entre 250-300 g, oriundos do Laboratório de Cirurgia Experimental da Universidade Federal do Ceará. Sob anestesia inalatória procedia-se uma pequena incisão supraumbilical, e com manobra delicada fazia-se a exposição do rim direito. Neste órgão eram inoculadas 3x10(5) células tumorais viáveis. Os animais então eram mantidos em gaiolas individuais com as mesmas condições ambientais e com água e dieta ad libitum. RESULTADOS: o Carcinossarcoma 256 de Walker, implantado no parênquima do rim direito de ratos Wistar apresentou índice de pega de 100%, e crescimento rápido, invadiu por contiguidade as estruturas vizinhas, porém sem apresentar metástases, no entanto, levando os animais a óbito no curso médio de 14 dias. CONCLUSÃO: o modelo de implante de tumor de Walker no parênquima do rim direito de ratos Wistar é eficiente, tem reprodutibilidade, apresentando um índice de pega de 100%, e permitindo seu uso em linhas de pesquisa.Walker carcinossarcoma 256 has a great interest as experimental model for studies on tumoral biology. OBJECTIVE: develop a kidney tumor model to be used in the evaluation of the biological behavior of neoplasms in vitro and in vivo environments. METHODS: twenty adult male Wistar rats weighting between 250-300 g were obtained from the Federal University of the Ceará Experimental Surgery Laboratory. Upon ether anesthesia, the right kidney of each animal was accessed through a supraumbelical incision and inoculated with a solution containing 3 x 10(5) tumor cells (Walker 256 carcinossarcoma tumor cells). Following anesthetic recovery the rats were returned to their cages, housed individually and allowed to eat and drink ad libitum. RESULTS: the post-operative average survival was 14 days. Tumor growth was encountered in all animals. The rats exhibited destruction of the kidney, invasion of the adjacent structures, but absence of metastasis. CONCLUSION: the kidney Walker tumor model proved to be an excellent tool for experimental studies on tumor behavior, due to its rapid growth and its easy reproduction.

Lúcio Flávio Gonzaga Silva; Felipe dos Santos Dias Soares; José Nilson Nunes Anselmo; Daniel Mota Moura Fé; João Luiz Barbosa Gurgel Cavalcante; Manoel Odorico de Moraes; Paulo Roberto Leitão de Vasconcelos

2002-01-01

254

Cyclic load testing and ultimate failure strength of suture anchors in the acetabular rim.  

UK PubMed Central (United Kingdom)

PURPOSE: To determine the resistance to cyclic stress and load-to-failure strength of several suture anchors suitable for hip arthroscopy. METHODS: Ten polyetheretherketone (PEEK) PushLock, PEEK SutureTak, and Bio-SutureTak anchors (Arthrex, Naples, FL); Lupine Loop BR anchors (DePuy Mitek, Norwood, MA); Bio-Mini Revo anchors (ConMed Linvatec, Largo, FL); and BioRaptor 2.9 AB anchors (Smith & Nephew, Andover, MA) were inserted in rotation into different locations on the rim of 4 matched pairs of potted acetabula clamped to the base of a servohydraulic testing machine. The anchors' sutures were cyclically pulled in line with the insertion angle. Displacement at 100 and 500 cycles, yield load, ultimate failure load, and failure mode were recorded. Statistical analysis was performed. RESULTS: Most of the displacement observed during cyclic loading occurred in the first 100 cycles, except for the BioRaptor 2.9 AB, which showed twice as much displacement at 500 cycles as at 100 cycles. The Lupine Loop BR cyclic displacement was greater than that of the PEEK PushLock (at 100 cycles also), Bio-SutureTak, and PEEK SutureTak at 500 cycles (P < .05). The BioRaptor 2.9 AB cyclic displacement was significantly greater at 100 and 500 cycles than that of the PEEK PushLock and Bio-SutureTak (P < .05). The mean ultimate failure loads for these anchors ranged from 154 N (PEEK SutureTak) to 255 N (Bio-Mini Revo) and was statistically equivalent (P = .139). Correlation analysis showed no significant associations between anchor stiffness, cyclic load displacement, or failure load. CONCLUSIONS: Anchors with specific indications for hip arthroscopy showed very little displacement and had consistent failure loads under cyclic conditions in the acetabular rim. All hip anchors except the BioRaptor 2.9 AB showed less than 2.0 mm of displacement after 500 cycles. CLINICAL RELEVANCE: Biomechanical testing of suture anchors designated for hip arthroscopy should be performed in the acetabular rim before their use. Suture anchors used for shoulder arthroscopy may not perform as well in the hip.

Ruiz-Suarez M; Aziz-Jacobo J; Barber FA

2010-06-01

255

New prospects for plutonium speciation - CE-RIMS and CE-DAD-ICP-MS  

International Nuclear Information System (INIS)

[en] Full text of publication follows: In the last years, capillary electrophoresis (CE)-ICP-MS has been applied successfully for the speciation of plutonium and neptunium [1] in aqueous solutions, especially in groundwater samples. To achieve lower detection limits and to determine complexing agents, two detection methods, namely RIMS and DAD, coupled with the separation technique CE are under investigation. A detection limit of 20 ppb was found for plutonium with an ICP-QMS, whereas with the coupling with a sector field ICP-HRMS 100 ppt could be detected. The off-line coupling of CE to the very sensitive resonance ionisation mass spectrometry (RIMS) with an absolute detection limit of 106 atoms gives new options. For this, a sample is injected into the CE-capillary and the separated oxidation states of Pu(III), Pu(VI/V) and Pu(IV) are collected in different fractions from which filaments are prepared for the RIMS measurements [2]. The migration times of the different Pu species have been previously calibrated by means of the CE-ICP-MS. The second innovation is the combination of a diode array detector (DAD) with the CE-ICP-MS. In addition to the information on the metal ions detected by the ICP-MS, the DAD can detect complexing agents like humic acid and also the electro-osmotic flow (EOF) by a suitable marker like acetone. This is necessary for internal standardisation of the migration times of the species in the capillary. By applying both detection methods, it is possible to determine in an anionic run free humic acid, humate complexed metal ions, and other (humate free) anionic metal species. In a cationic run, the free metal ions can be detected. This will enable the determination of complex formation constants. Related results will be presented at the conference. [1] B. Kuczewski et al.: Analytical Chemistry, 2003, 75, 6769-6774. [2] N. Trautmann et al.: Analytical and Bioanalytical Chemistry, 2004, 378, 348-355. (authors)

256

Bone induction using autogenous bone mixed with demineralised bone matrices.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The aim of the present study was to examine the healing of endochondral (EC) autogenous bone grafts in the presence of demineralised bone matrix prepared from intramembranous bone (DBMIM), or prepared from endochondral bone (DBMEC) using quantitative analysis. Thirty bone defects were created on the...

Rabie, AB; Wong, RW; Hägg, U

257

Bone Densitometry  

Medline Plus

Full Text Available ... a higher risk of developing osteoporosis. Too little exercise, as well as bed rest, weakens the bones. ... alcohol tend to also make osteoporosis worse. Sustained exercise, such as running marathons, decreases the levels of ...

258

An Investigation on the Morphological Evolution of Bright-Rimmed Clouds  

CERN Document Server

A new Radiative Driven Implosion (RDI) model based on Smoothed Particle Hydrodynamics (SPH) technique is developed and applied to investigate the morphological evolutions of molecular clouds under the effect of ionising radiation. This model self-consistently includes the self-gravity of the cloud in the hydrodynamical evolution, the UV radiation component in the radiation transfer equations, the relevant heating and cooling mechanisms in the energy evolution and a comprehensive chemical network. The simulation results reveal that under the effect of ionising radiation, a molecular cloud may evolve through different evolutionary sequences. Dependent on its initial gravitational state, the evolution of a molecular cloud does not necessarily follow a complete morphological evolution sequence from type A to B to C, as described by previous RDI models. When confronted with observations, the simulation results provide satisfactory physical explanations for a series of puzzles derived from Bright-Rimmed Clouds (BRC...

Miao, J; Thompson, M A; Nelson, R P

2008-01-01

259

The insect-trapping rim of Nepenthes pitchers: surface structure and function.  

UK PubMed Central (United Kingdom)

Carnivorous pitcher plants of the genus Nepenthes capture prey with a pitfall trap that relies on a micro-structured, slippery surface. The upper pitcher rim (peristome) is fully wettable and causes insects to slip by aquaplaning on a thin water film. The high wettability of the peristome is probably achieved by a combination of hydrophilic surface chemistry, surface roughness and the presence of hygroscopic nectar. Insect foot attachment could be prevented by the delayed drainage of the thin water film between the adhesive pad and the surface. Drainage should be faster for insects with a hairy adhesive system; however, they slip equally on the wet peristome. Therefore the stability of the water film against dewetting appears to be the key factor for aquaplaning. New experimental techniques may help to clarify the detailed function of the pitcher plant peristome and to explore its potential for biomimetic applications.

Bauer U; Federle W

2009-11-01

260

Infrared observations of Barnard 35: Heat sources for bright-rimmed molecular clouds  

International Nuclear Information System (INIS)

We have conducted a deep 2 mm wavelength infrared survey of an extended region of enhanced 12CO emission in the bright-rimmed molecular cloud Barnard 35 in order to search for embedded heat sources. Twelve infrared sources were detected, all of which have been identified with visible, apparently foreground stars. Optical spectra were obtained for most of these sources, and we found them to be of relatively late spectral type (i.e., F8 and later). Two of the sources we detected are Ha emission-line, Orion population stars, one of which had been previously classified as Gea. However, we found no evidence for an embedded population of either early type (i.e., B and earlier) or intermediate type (F and earlier) stars in the cloud

1980-12-15

 
 
 
 
261

Infrared observations of Barnard 35: Heat sources for bright-rimmed molecular clouds  

Energy Technology Data Exchange (ETDEWEB)

We have conducted a deep 2 mm wavelength infrared survey of an extended region of enhanced /sup 12/CO emission in the bright-rimmed molecular cloud Barnard 35 in order to search for embedded heat sources. Twelve infrared sources were detected, all of which have been identified with visible, apparently foreground stars. Optical spectra were obtained for most of these sources, and we found them to be of relatively late spectral type (i.e., F8 and later). Two of the sources we detected are Ha emission-line, Orion population stars, one of which had been previously classified as Gea. However, we found no evidence for an embedded population of either early type (i.e., B and earlier) or intermediate type (F and earlier) stars in the cloud.

Lada, C.J.; Wilking, B.A.

1980-12-15

262

[Changes and analysis of soil quality under different land use types in oasis rim].  

UK PubMed Central (United Kingdom)

The aggravation process of oasisization leads to changes of land use type in oasis rim. In order to discuss the effects of different land use types on soil properties and soil quality, the four land use types located Cele oasis rim in south margin of Tarim Basin, which are the cotton field, orchard, and Caligonum mongolicum Turcz land use type reclaimed by people and nature state land use type covered by Alhagi sparsifolia SHAP, were selected as study object. The relative soil quality index (RI) and the soil quality synthesis index (SQI) were used to analyse the changes of soil quality between four land use types within 0-20 cm, 2040 cm, 40-60 cm soil depth, respectively. Meantime, the fractal theory was used to analyse the particle-size distribution (PSD) property of top soil under different land use types. The results indicated that there was a significant difference in the soil organic matter and total nitrogen in same soil depth between four land use types; the order ranked according to RI was same to the order ranked according to SQI in each soil depth between four land use types. The cotton field and orchard have an obviously positive effect on soil quality of the top soil, however, the soil quality of Alhagi sparsifolia SHAP land use type was gradually increasing along with the increasing soil depth. The soil properties and soil quality of Caligonum mongolicum Turcz land use type were at the lowest level according to the comparison results among all land use types, and the calculation results of PSD fractal dimension also indicated the Caligonum mongolicum Turcz land use type had the worst ability on maintaining soil fine fractions.

Gui DW; Lei JQ; Zeng FJ; Mu GJ; Yang FX; Zhu JT

2010-09-01

263

[Changes and analysis of soil quality under different land use types in oasis rim].  

Science.gov (United States)

The aggravation process of oasisization leads to changes of land use type in oasis rim. In order to discuss the effects of different land use types on soil properties and soil quality, the four land use types located Cele oasis rim in south margin of Tarim Basin, which are the cotton field, orchard, and Caligonum mongolicum Turcz land use type reclaimed by people and nature state land use type covered by Alhagi sparsifolia SHAP, were selected as study object. The relative soil quality index (RI) and the soil quality synthesis index (SQI) were used to analyse the changes of soil quality between four land use types within 0-20 cm, 2040 cm, 40-60 cm soil depth, respectively. Meantime, the fractal theory was used to analyse the particle-size distribution (PSD) property of top soil under different land use types. The results indicated that there was a significant difference in the soil organic matter and total nitrogen in same soil depth between four land use types; the order ranked according to RI was same to the order ranked according to SQI in each soil depth between four land use types. The cotton field and orchard have an obviously positive effect on soil quality of the top soil, however, the soil quality of Alhagi sparsifolia SHAP land use type was gradually increasing along with the increasing soil depth. The soil properties and soil quality of Caligonum mongolicum Turcz land use type were at the lowest level according to the comparison results among all land use types, and the calculation results of PSD fractal dimension also indicated the Caligonum mongolicum Turcz land use type had the worst ability on maintaining soil fine fractions. PMID:21072954

Gui, Dong-Wei; Lei, Jia-Qiang; Zeng, Fan-Jiang; Mu, Gui-Jin; Yang, Fa-Xiang; Zhu, Jun-Tao

2010-09-01

264

Nonthermal emission properties of the northwestern rim of supernova remnant RX J0852.0-4622  

Science.gov (United States)

The supernova remnant (SNR) RX J0852.0-4622 (Vela Jr., G266.6-1.2) is one of the most important SNRs for investigating the acceleration of multi-TeV particles and the origin of Galactic cosmic rays because of its strong synchrotron X-ray and TeV ?-ray emission, which show a shell-like morphology similar to each other. Using the XMM-Newton archival data consisting of multiple pointing observations of the northwestern rim of the remnant, we investigate the spatial properties of the nonthermal X-ray emission as a function of distance from an outer shock wave. All X-ray spectra are well reproduced by an absorbed power-law model above 2 keV. It is found that the spectra show gradual softening from a photon index ? = 2.56 in the rim region to ? = 2.96 in the interior region. We show that this radial profile can be interpreted as a gradual decrease of the cutoff energy of the electron spectrum due to synchrotron cooling. By using a simple spectral evolution model that includes continuous synchrotron losses, the spectral softening can be reproduced with the magnetic field strength in the post-shock flow to less than several tens of ?G. If this is a typical magnetic field in the SNR shell, ?-ray emission would be accounted for by inverse Compton scattering of high-energy electrons that also produce the synchrotron X-ray emission. Future hard X-ray imaging observations with Nustar and ASTRO-H and TeV ?-ray observations with the Cherenkov Telescope Array (CTA) will allow us to explore other possible explanations of the systematic softening of the X-ray spectra.

Kishishita, T.; Hiraga, J.; Uchiyama, Y.

2013-03-01

265

RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Reverse Phase Protein Arrays (RPPA) are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technologies, substantial amounts of analytical data are generated. Over 1000 samples may be printed on a single nitrocellulose slide. Up to 100 different proteins may be assessed using immunoperoxidase or immunoflorescence techniques in order to determine relative amounts of protein expression in the samples of interest. Results In this report an RPPA Information Management System (RIMS) is described and made available with open source software. In order to implement the proposed system, we propose a metadata format known as reverse phase protein array markup language (RPPAML). RPPAML would enable researchers to describe, document and disseminate RPPA data. The complexity of the data structure needed to describe the results and the graphic tools necessary to visualize them require a software deployment distributed between a client and a server application. This was achieved without sacrificing interoperability between individual deployments through the use of an open source semantic database, S3DB. This data service backbone is available to multiple client side applications that can also access other server side deployments. The RIMS platform was designed to interoperate with other data analysis and data visualization tools such as Cytoscape. Conclusion The proposed RPPAML data format hopes to standardize RPPA data. Standardization of data would result in diverse client applications being able to operate on the same set of data. Additionally, having data in a standard format would enable data dissemination and data analysis.

Stanislaus Romesh; Carey Mark; Deus Helena F; Coombes Kevin; Hennessy Bryan T; Mills Gordon B; Almeida Jonas S

2008-01-01

266

Distal myopathy with rimmed vacuoles: Report on clinical characteristics in 23 cases  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Distal myopathy with rimmed vacuoles (DMRV) is an autosomal recessive (AR) myopathy characterized clinically by the preferential involvement of the tibialis anterior and has been reported predominantly in the Japanese population. Materials and Methods: A case series of DMRV patients seen over a period of 3 years at a tertiary national referral center for neurological disorders in south India. Results: We describe the clinical characteristics, muscle magnetic resonance imaging (MRI) findings and classical histopathological feature in 23 patients. There were 12 men and 11 women. Mean age of onset was 27.04 ± 6.35 years (10-39 years). Onset was in the second or third decade in a majority. Mean age at presentation was 33.95 ± 6.35 years (25-48 years). Mean duration of illness was 6.74 ± 4.8 years (1-18 years). Consanguinity was reported in eight (34.8%) patients. The predominant and initial manifestation was bilateral foot drop in all patients. Muscle MRI demonstrated classical involvement of the anterior compartment muscles of the lower legs and the posterior compartment muscles of the thighs and the quadriceps was normal in all. Muscle histopathology showed numerous fibers containing rimmed vacuoles. Necrotic fibers or phagocytosis or regenerating fibers were rarely noted or were absent. Conclusions: DMRV is a rare AR myopathy. The disorder presents as progressive foot drop and hence has many differential diagnoses. It is easily mistaken as neuropathy of hereditary nature and hence it is extremely important to recognize the preferential muscle involvement and characterize the phenotype. This is the first report from India with patients having characteristic phenotype of Nonaka?s/AR hereditary inclusion body myopathy with quadriceps sparing, and all were confirmed by histopathology.

Nalini A; Gayathri N; Dawn Rose

2010-01-01

267

A Comparison of Rates of Change in Neuroretinal Rim Area and Retinal Nerve Fiber Layer Thickness in Progressive Glaucoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Longitudinal analyses of the rates of deterioration in both the rim area and retinal nerve fiber layer provide valuable additional information for the management of glaucoma patients. We observed in this study that the ability to discriminate progressing eyes from stable eyes was greater with nerve ...

Alencar, Luciana M.; Zangwill, Linda M.; Weinreb, Robert N.; Bowd, Christopher; Sample, Pamela A.; Girkin, Christopher A.

268

Introduction of glyco, peptido, carboxy, and alkyno substituents at the calixarene exo rim via the p-bromodienone route.  

Science.gov (United States)

The conceptually novel "p-bromodienone route", which allows the direct introduction of nucleophiles at the calixarene exo rim, has been extended to anionic C-nucleophiles (acetylides) to give chiral meta-substituted alkynocalix[4]arenes and to appropriate O-nucleophiles to obtain para-substituted glyco, peptido, and carboxy derivatives. PMID:22420686

Gaeta, Carmine; Troisi, Francesco; Talotta, Carmen; Pierro, Teresa; Neri, Placido

2012-03-27

269

Introduction of glyco, peptido, carboxy, and alkyno substituents at the calixarene exo rim via the p-bromodienone route.  

UK PubMed Central (United Kingdom)

The conceptually novel "p-bromodienone route", which allows the direct introduction of nucleophiles at the calixarene exo rim, has been extended to anionic C-nucleophiles (acetylides) to give chiral meta-substituted alkynocalix[4]arenes and to appropriate O-nucleophiles to obtain para-substituted glyco, peptido, and carboxy derivatives.

Gaeta C; Troisi F; Talotta C; Pierro T; Neri P

2012-04-01

270

Apparatus for efficient sidewall containment of molten metal with horizontal alternating magnetic fields utilizing low reluctance rims  

Energy Technology Data Exchange (ETDEWEB)

A method and apparatus for casting sheets of metal from molten metal. The apparatus includes a containment structure having an open side, a horizontal alternating magnetic field generating structure and rollers including low reluctance rim structures. The magnetic field and the rollers help contain the molten metal from leaking out of the containment structure.

Praeg, Walter F. (Palos Park, IL)

1999-01-01

271

Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.  

UK PubMed Central (United Kingdom)

A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.

Chen X; Ji M; Fisher DR; Wai CM

1999-09-01

272

Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.  

Science.gov (United States)

A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage. PMID:20651937

Chen, Xiaoyuan; Ji, Min; Fisher, Darrell R; Wai, Chien M

1999-09-01

273

Disruption of rimP-SC, encoding a ribosome assembly cofactor, markedly enhances the production of several antibiotics in Streptomyces coelicolor.  

UK PubMed Central (United Kingdom)

BACKGROUND: Ribosome assembly cofactor RimP is one of the auxiliary proteins required for maturation of the 30S subunit in Escherichia coli. Although RimP in protein synthesis is important, its role in secondary metabolites biosynthesis has not been reported so far. Considering the close relationship between protein synthesis and the production of secondary metabolites, the function of ribosome assembly cofactor RimP on antibiotics production was studied in Streptomyces coelicolor and Streptomyces venezuelae. RESULTS: In this study, the rimP homologue rimP-SC was identified and cloned from Streptomyces coelicolor. Disruption of rimP-SC led to enhanced production of actinorhodin and calcium-dependent antibiotics by promoting the transcription of actII-ORF4 and cdaR. Further experiments demonstrated that MetK was one of the reasons for the increment of antibiotics production. In addition, rimP-SC disruption mutant could be used as a host to produce more peptidyl nucleoside antibiotics (polyoxin or nikkomycin) than the wild-type strain. Likewise, disruption of rimP-SV of Streptomyces venezuelae also significantly stimulated jadomycin production, suggesting that enhanced antibiotics production might be widespread in many other Streptomyces species. CONCLUSION: These results established an important relationship between ribosome assembly cofactor and secondary metabolites biosynthesis and provided an approach for yield improvement of secondary metabolites in Streptomyces.

Pan Y; Lu C; Dong H; Yu L; Liu G; Tan H

2013-01-01

274

Bone: From planar imaging to SPECT & PET/CT  

Directory of Open Access Journals (Sweden)

Full Text Available Since its introduction into clinical medicine 50 years ago, the radionuclide bone scan has played a key role in diagnosing a variety of osseous disorders; particularly metastatic disease. Using small diagnostic doses of Strontium-85 in the 1960’s, it was rapidly established that the study was much more sensitive than skeletal radiographs. The introduction of Technetium-99m phosphate agents in the early 1970’s, offered greatly improved resolution. Whole body imaging became the standard procedure. Interestingly, the positron-emitter, Fluorine 18-sodium fluoride was used by some investigators with the rectilinear scanner. Very recently, this radiotracer has been re-introduced and is witnessing considerable growth using modern PET/CT instrumentation. The cortical bone tracers, 99mTc-MDP and 18F-Fluoride assess osteoblastic response to the invading lesion. In the study of metastatic disease, it is superb for sclerotic blastic lesions. Although it detects most lytic lesions, many can be missed. This is due to a lack of osteoblastic response. The tumor may be slow growing, such as myeloma or conversely very rapidly growing and destructive, such as lung or kidney metastases. In these lesions, 18F-FDG is superior because it is concentrating in the tumor cells and does not depend on osteoblastic response to the tumor. In their early cause, many lytic lesions may be confined to the medullary portion of bone and not yet involve the cortex. Comparative studies of PET and CT have clearly shown the superior sensitivity of FDG in detecting metastatic bone lesions.

Mihailovi? Jasna; Freeman Leonard M.

2012-01-01

275

Gaucher disease: MR evaluation of bone marrow features during treatment with enzyme replacement  

International Nuclear Information System (INIS)

Purpose: Enzyme replacement therapy (ERT) arrests and reverses the hematological and visceral symptoms of adult Gaucher disease, the most frequent lysosomal storage disorder. There are only a few studies available evaluating bone disease during ERT. The aim of this study was to investigate the features of bone marrow (bm) by magnetic resonance imaging (MRI) in these patients during ERT. Materials and Methods: MRI was performed prospectively in thirty adult type I Gaucher patients before and during ERT with a mean follow-up of 3 years. Spin-echo sequences (T1/T2) of the lower extremities were obtained and the reconversion (response) or lack of reconversion (non-response) to fatty marrow during treatment was analyzed. The morphological features of bm involvement, a homogeneous or non-homogeneous distribution of bm changes and focal bone lesions surrounded by a rim of reduced signal intensity (SI), were analyzed. Results: Infiltration of bm by Gaucher cells is characterized by a reduction of Sl on both T1- and T2-weighted sequences. Bone marrow responses were seen in 19 patients (63%) during treatment. Focal bone lesions, surrounded by a rim of reduced Sl, did not respond to ERT and correlated with a non-homogenous distribution of bone involvement and splenectomy. (orig.)

2001-01-01

276

Poly-alpha-glutamic acid synthesis using a novel catalytic activity of RimK from Escherichia coli K-12.  

UK PubMed Central (United Kingdom)

Poly-L-?-amino acids have various applications because of their biodegradable properties and biocompatibility. Microorganisms contain several enzymes that catalyze the polymerization of L-amino acids in an ATP-dependent manner, but the products from these reactions contain amide linkages at the side residues of amino acids: e.g., poly-?-glutamic acid, poly-?-lysine, and cyanophycin. In this study, we found a novel catalytic activity of RimK, a ribosomal protein S6-modifying enzyme derived from Escherichia coli K-12. This enzyme catalyzed poly-?-glutamic acid synthesis from unprotected L-glutamic acid (Glu) by hydrolyzing ATP to ADP and phosphate. RimK synthesized poly-?-glutamic acid of various lengths; matrix-assisted laser desorption ionization-time of flight-mass spectrometry showed that a 46-mer of Glu (maximum length) was synthesized at pH 9. Interestingly, the lengths of polymers changed with changing pH. RimK also exhibited 86% activity after incubation at 55°C for 15 min, thus showing thermal stability. Furthermore, peptide elongation seemed to be catalyzed at the C terminus in a stepwise manner. Although RimK showed strict substrate specificity toward Glu, it also used, to a small extent, other amino acids as C-terminal substrates and synthesized heteropeptides. In addition, RimK-catalyzed modification of ribosomal protein S6 was confirmed. The number of Glu residues added to the protein varied with pH and was largest at pH 9.5.

Kino K; Arai T; Arimura Y

2011-03-01

277

MR-guided bone biopsy performed with a new coaxial drill system  

International Nuclear Information System (INIS)

Purpose: To describe the development and clinical evaluation of a new, hand-powered or alternatively motor-driven, MRI and CT compatible percutaneous bone biopsy system. Materials and Methods: A new coaxial drill system (Cook Europe A/S) was designed for percutaneous, MR-guided bone biopsies and powered either by hand or an optional motor (10-250 rotations/minute using 6 bar [88.2 PSI] compressed air). The system has been used in 23 patients. Fourteen procedures were performed in a 1.5 T MR scanner (Philips-Gyroscan ACS-NT) which has an attached C-arm (Philips-BV 212-Angio) in case fluoroscopy is required, and 9 procedures in a CT scanner (Siemens-Somatom Plus). Results: Driven by hand or by the pneumatic motor unit, the system achieved safe and accurate MR-guided access to all of the lesions and was even able to penetrate osteosclerotic lesions. MR- or CT-guided percutaneous biopsy yielded a correct diagnosis in all but 5 cases. No procedural complications occurred. Conclusion: MR-guided percutaneous bone biopsy performed with the new coaxial drill system was found to be safe and reliable, and suitable for obtaining histological specimens from skeletal lesions even when covered with thick cortical or sclerotic bone. (orig.)

1998-01-01

278

Osteoid osteoma of a metacarpal bone: A case report and review of the literature  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Introduction Osteoid osteoma is a benign tumor of the growing skeleton. It presents with pain, which is usually worse at night. The radiographic features consist of a central oval or round nidus surrounded first by a radiolucent area followed by another area of sclerotic bone. In the hand, osteoid osteoma is more commonly located in the phalanges and carpal bones. The metacarpals are the least common sites for osteoid osteoma. Case presentation We present a case of an osteoid osteoma of the left third metacarpal bone in a 36-year-old woman. The clinical and radiographic findings along with the surgical management of the lesion are presented. The pain disappeared immediately after the operation. At the 2-year follow-up, the patient was pain-free and there was no evidence of recurrence. Conclusion Physicians should be aware of the unusual presence and the atypical clinical presentation of this benign lesion in the metacarpal bones of the hand.

Chronopoulos Efstathios; Xypnitos Fragiskos N; Nikolaou Vassilios S; Efstathopoulos Nicolas; Korres Dimitrios

2008-01-01

279

Subperiosteal ganglion associated with Paget's disease of bone  

International Nuclear Information System (INIS)

Tumoral lesions related to Paget's disease may be classified as malignant, benign or pseudotumoral. While sarcomatous degeneration is the most feared complication, awareness of benign and pseudotumoral lesions is essential for assisting in accurate histological interpretation of the biopsy sample, which may avoid unnecessary repeat biopsies. We present the first case of a juxta-articular subperiosteal ganglion associated with Paget's disease, with classic imaging characteristics, especially on CT examination. The well-defined soft tissue mass at the medial aspect of the obturator rim, adjacent to a small fracture in pagetic quadrilateral plate, showed an ossified rim and internal gas lucencies, these being the hallmarks of a juxta-articular subperiosteal ganglion. On MRI, the lesion was of intermediate signal intensity on T1-weighted sequences, increased signal intensity on T2-weighted sequences, with rim enhancement after gadolinium contrast injection and preservation of fatty marrow signal of the underlying pagetic bone. Identification of the entity avoided an unnecessary biopsy or surgical intervention. (orig.)

2005-01-01

280

Bone lesion biopsy  

Science.gov (United States)

Bone biopsy; Biopsy - bone ... biopsy needle is pushed and twisted into the bone. Once the sample is obtained, the needle is ... stitches are applied, and covered with a bandage. Bone biopsy may also be done under general anesthesia ...

 
 
 
 
281

Bone Densitometry  

Medline Plus

Full Text Available ... special device. Bone Densitometry Machine Most machines use x-rays but some use ultrasound. A densitometry machine can ... is very safe. However, the machines that use x-rays should not be used on pregnant women. This ...

282

Experimental Studies on Diffusion-Controlled rim Growth in the System MgO-SiO2 and in Decarbonation Reactions  

Science.gov (United States)

The kinetics of subsolidus reactions in rocks are often controlled by grain-boundary diffusion, e.g. the formation of corona structures in metamorphic rocks. During the last decades the modelling of layered corona structures has strongly evolved. The most important information derived from these models are relative migration rates of the involved chemical components. However, the derivation of absolute diffusion rates is largely hampered by uncertainties in the P-T-t paths during rim growth and other unknowns, like the effect of eventual coexisting fluids. Studies on metamorphic reaction rims must therefore by complemented by experiments. In rim growth experiments grain boundary diffusion rates of single components can be measured as functions of pressure, temperature, fluid composition, and matrix phases. Additionally, model concepts can be approved, like attainment of local equilibrium at layer interfaces, reference frames related to interface migration, and microtextural evolution of the rims. We focused on two systems that were already subject of experimental or field studies before: (i) wollastonite rims between calcite and quartz, and (ii) rim growth in the system MgO-SiO2 involving periclase, forsterite, enstatite, and quartz. Wollastonite rim growth was studied in the P-T range from 0.1 to 1 GPa and 850 to 1200oC. The rim formation is interpreted in a volume conserving reference frame. Relative diffusion rates of CaO and SiO2 react sensitively to traces of water. Diffusion in both dry and water-bearing systems is orders of magnitude slower than during rim growth in contact aureoles, however, the growth textures are very similar. Enstatite rim growth around forsterite grains in quartz was studied using isotope tracers and SIMS. The method allowed the exact identification of the enstatite-forming partial reactions and the independent measurement of MgO and Si-diffusion rates. Rim widths are controlled by MgO diffusion, whereas Si is almost immobile. Zoned forsterite-enstatite rims form around periclase grains in quartz. Although there is practically no Si diffusion across the enstatite zone, there is an apparent flux of Si due to migration of the entatite zone into the quartz matrix. Rim growth of this type can only be understood by considering the volume changes during reactions at the layer interfaces.

Milke, R.; Heinrich, W.; Wiedenbeck, M.; Wunder, B.

2001-12-01

283

Hand-rim forces and gross mechanical efficiency at various frequencies of wheelchair propulsion.  

UK PubMed Central (United Kingdom)

To determine the effects of push frequency changes on force application, fraction of effective force (FEF) and gross efficiency (GE) during hand-rim propulsion. 8 male able-bodied participants performed five 4-min sub-maximal exercise bouts at 1.8 ms(-1); the freely chosen frequency (FCF), followed by 4 counter-balanced trials at 60, 80, 120 and 140% FCF. Kinetic data was obtained using a SMART(Wheel), measuring forces and moments. The GE was determined as the ratio of external work done and the total energy expended. Increased push frequency led to reductions in peak resultant force (P<0.05), ranging from 167 to 117 N and peak tangential force (P<0.05), ranging from 117 to 77 N. However, FEF only demonstrated a significant difference between 60% and 140% FCF (69 ± 9% and 63 ± 7, respectively; P<0.05). Work per cycle decreased significantly (P<0.05) and rate of force development increased significantly (P<0.05) with increased push frequency. GE values were significantly lower at 60%, 120% and 140% FCF than 80% and 100% FCF (P<0.05). No meaningful associations were present between FEF and GE. Under the current testing conditions, changes in push frequency are accompanied with changes in the absolute force values, albeit without changes in either the gross pattern/trend of force application or FEF. Changes in GE are not explained by different levels of force effectiveness.

Lenton JP; van der Woude LH; Fowler NE; Nicholson G; Tolfrey K; Goosey-Tolfrey VL

2013-02-01

284

Engineering innovation at Xstrata's Nickel Rim South surface exhaust fans  

Energy Technology Data Exchange (ETDEWEB)

The Nickel Rim South Project involves the construction of a new underground metal mine in Sudbury. Two shafts are used to access the ore, notably one production shaft in fresh air and one ventilation shaft for exhaust air. A pair of exhaust fans located at the surface near the collar of the ventilation shaft are used to drive the primary mine ventilation circuit. This paper described the technical aspects of the exhaust fan system with particular focus on the basic engineering stage. The innovative approaches in ventilation were the use of silencing, condensed water collection and handling, and an exhaust stack. The automated system includes the use of variable frequency drives, multi-fan programmable logic control and fan starting considerations. This paper also described the computer modelling tools used in this projects, such as gas dispersion modelling, computational fluid dynamics, sound analysis and suspended particle modelling. The design of the exhaust system minimizes the potential for disruption to operation. Each fan system is independent so that a single component failure would rarely shut down both fans. The system met Xstrata's sustainable development objectives in terms of safety, reliability and environmental improvements. 2 tabs., 6 figs.

Witow, D.R. [Hatch, Sudbury, ON (Canada); McCall, J. [Xstrata Nickel, Sudbury, ON (Canada)

2010-07-01

285

H$_2$O maser emission from bright rimmed clouds in the northern hemisphere  

CERN Multimedia

We report the results of a multi-epoch survey of water maser observations at 22.2 GHz with the Medicina radiotelescope from 44 bright rimmed clouds (BRCs) of the northern hemisphere identified by Sugitani et al. (1989) as potential sites of star formation. The data span 16 years of observations and allow to draw conclusions about the maser detection rate in this class of objects. In spite of the relatively high far-infrared luminosities of the embedded sources ($L_{\\rm FIR}\\ga 10^2$ L$_\\odot$), H$_2$O maser emission was detected towards three globules only. Since the occurrence of water masers is higher towards bright IRAS sources, the lack of frequent H$_2$O maser emission is somewhat surprising if the suggestion of induced intermediate- and high-mass star formation within these globules is correct. The maser properties of two BRCs are characteristic of exciting sources of low-mass, while the last one (BRC~38) is consistent with an intermediate-mass object. We argue that most BRCs host young stellar objects ...

Valdettaro, R; Brand, J; Cesaroni, R

2005-01-01

286

Building for the Pacific Rim Countries. Energy-efficient building strategies for hot, humid climates  

Energy Technology Data Exchange (ETDEWEB)

This book has been published by the Solar Energy Industries Association (SEIA), the US trade association of the solar thermal, photovoltaic, and passive solar manufacturers, distributors, and component suppliers. Its purpose is to help architects, builders, and developers construct energy-efficient homes in hot humid climates like the Pacific Rim Countries, and to allow occupants of these homes to enjoy enhanced comfort without reliance on mechanical air-conditioning systems. Two important factors are addressed in this book. First, the past few years have seen a tremendous increase in practical applications of new research. The current popularity of ceiling paddle fans, attic radiant barriers and natural daylighting attest to the importance of keeping up with the latest concepts in energy-reduction and comfort-awareness. Professionals who have been in the field for the past few years may be unaware of the latest research findings--some of which dramatically alter prior thinking on such subjects as natural ventilation or mechanical air conditioning. The second factor is the importance of site-specific characteristics, which greatly affect building strategies and designs. A thorough understanding of the climate is a prerequisite to good building design. Such factors as temperature, humidity, wind speed and direction, and solar radiation must be understood and properly integrated into the design for the home to be truly energy-efficient.

Sheinkopf, K. [ed.

1991-09-01

287

The stellar population and complex structure of the bright-rimmed cloud IC 1396N  

CERN Multimedia

Context. IC 1396N is a bright-rimmed cloud associated with an intermediate-mass star-forming region, where a number of Herbig-Haro objects, H2 jet-like features, CO molecular outflows, and millimeter compact sources have been observed. Aims. To study in detail the complex structure of the IC 1396N core and the molecular outflows detected in the region and to reveal the presence of additional YSOs inside this globule. Methods. We carried out a deep survey of the IC 1396N region in the J, H, K' broadband filters and deep high-angular resolution observations in the H2 narrowband filter with NICS at the TNG telescope. The completeness limits in the 2MASS standard are Ks~17.5, H~18.5 and J~19.5. Results. A total of 736 sources have been detected in all three bands within the area where the JHK' images overlap. There are 128 sources detected only in HK', 67 detected only in K', and 79 detected only in H. We found only few objects exhibiting a Near-Infrared excess and no clear signs of clustering of sources towards ...

Beltran, M T; López, R; Girart, J M; Estalella, R

2009-01-01

288

Bioclimate-Vegetation Interrelations along the Pacific Rim of North America  

Directory of Open Access Journals (Sweden)

Full Text Available This study was designed to examine relationships between climate and vegetation of the Pacific rim of North America, from the Mediterranean deserts of California to Alaska’s boreal taiga. Relations were inferred from temperature and rainfall data recorded at 457 weather stations and by sampling the vegetation around these stations. Climate data were used to construct climatograms, calculate forty one variables and detect main latitudinal and longitudinal gradients. In order to identify the best functions able to relate our variables, polynomial and non-polynomial regressions were performed. The k-means algorithm was the clustering method used to validate the variables that could best support our bioclimatic classification. The variable that best fitted our classification was finally used to prepare a discriminatory key for bioclimates. Across this extensive area three macrobioclimates were identified, Mediterranean, Temperate and Bo- real, within which we were able to distinguish nine bioclimates. Finally, we relate the different types of potential natural vegetation to each of these bioclimates and describe their floristic composition and physiognomy.

Manuel Peinado; Gustavo Díaz; José Delgadillo; Francisco Manuel Ocaña-Peinado; Miguel Ángel Macías; Juan Luis Aguirre; Alejandro Aparicio

2012-01-01

289

Origin of the Tertiary reservoired hydrocarbons along the central Texas and Louisiana Gulf Coast rim  

Energy Technology Data Exchange (ETDEWEB)

Tertiary reservoired hydrocarbons along the central Texas and Louisiana Gulf Coast rim were most likely derived from Paleocene/Eocene Wilcox Group and Sparta Formation marine shales. Sixteen total soluble extracts and >200 oil samples were analyzed using carbon isotopic techniques ({delta}{sup 13}C) and gas chromatography-mass spectometry (GC-MS). Results demonstrated that interpretations must use all types of data because Cretaceous derived and Tertiary derived oils overlap in southern Louisiana. When isotopic, sterane, hopane, and light hydrocarbon data are combined separation of classes become possible. Cretaceous oils and extracts have a full range of extended hopanes, a characteristic peak eluting immediately after C{sub 30} hopane and no oleanane. Paleogene oils and extracts have oleanane and a restricted range of extended hopanes. Regional trends indicate that eastern Louisiana oils were derived from the Sparta or a Sparta/Wilcox mix, the Mississippi delta oils from a Cretaceous clastic source, and western Louisiana and Texas oils from the Wilcox source. Regional variations in GOR/CGR are a function of timing and mechanism of migration.

Cole, G.A.; Sassen, R. (BP Exploration, Inc., Houston, TX (USA)); Chinn, E.W. (Louisiana State Univ., Baton Rouge (USA)); Piggott, N.; Gibbons, M.J.

1990-05-01

290

Electromagnetic evidence for an ancient avelanche caldera rim onthe south flank of mount merapi, indonesia  

Energy Technology Data Exchange (ETDEWEB)

Long-Offset Transient Electromagnetic (LOTEM) data andVIBROTEM data from the south flank of Mount Merapi on Java island,Indonesia, are interpreted with one-dimensional (1D) inversions as wellas two-dimensional (2D) forward modelling. One-dimensional jointinversions of several components of the electromagnetic field withOccam's method reduce the number of equivalent models, which were derivedfrom inversions of single components and fit the data to a similarmisfit. The 1D results, together with results from other geophysicalmeasurements, serve as the basic model for further 2D forward modelling.The final model depicts a layering that follows the topography of thestrato-volcano. In the depth range of 500 m to 1000 m, the resistivity ofthe layers decreases rapidly downwards into a good conductor withresistivities below 10 OMEGAm. The deepest layer has a resistivity of 0.4OMEGAm which is quantitatively explained with a combination of salinefluids and hydrothermally altered minerals. Furthermore, the final modelsupports a hypothesis from the interpretation of central-loop TEM(Transient Electromagnetic) data that there is a fault structure belowthe southern flank, approximately 7.3 km south of the summit. To thenorth of the fault, the top of the good conductor is lowered from a depthof 500 m to 1000 m. We propose that the fault structure coincides with anancient avalanche caldera rim.

Kalscheuer, T.; Commer, M.; Helwig, S.L.; Hoerdt, A.; Tezkan, B.

2006-02-28

291

Enhanced detection of open-angle glaucoma with an anatomically accurate optical coherence tomography-derived neuroretinal rim parameter.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Neuroretinal rim assessment based on the clinical optic disc margin (DM) lacks a sound anatomic basis for 2 reasons: (1) The DM is not reliable as the outer border of rim tissue because of clinically and photographically invisible extensions of Bruch's membrane (BM) inside the DM and (2) nonaccountability of rim tissue orientation in the optic nerve head (ONH). The BM opening-minimum rim width (BMO-MRW) is a parameter that quantifies the rim from its true anatomic outer border, BMO, and accounts for its variable orientation. We report the diagnostic capability of BMO-MRW. DESIGN: Case control. PARTICIPANTS: Patients with open-angle glaucoma (n = 107) and healthy controls (n = 48). METHODS: Spectral-domain optical coherence tomography (SD-OCT) with 24 radial and 1 circumpapillary B-scans, centered on the ONH, and confocal scanning laser tomography (CSLT) were performed. The internal limiting membrane (ILM) and BMO were manually segmented in each radial B-scan. Three SD-OCT parameters were computed globally and sectorally: (1) circumpapillary retinal nerve fiber layer thickness (RNFLT); (2) BMO-horizontal rim width (BMO-HRW), the distance between BMO and ILM in the BMO reference plane; and (3) BMO-MRW, the minimum distance between BMO and ILM. Moorfields Regression Analysis (MRA) with CLST was performed globally and sectorally to yield MRA1 and MRA2, where "borderline" was classified as normal and abnormal, respectively. MAIN OUTCOME MEASURES: Sensitivity, specificity, and likelihood ratios (LRs) for positive and negative test results (LR+/LR-). RESULTS: The median (interquartile range) age and mean deviation of patients and controls were 69.9 (64.3-76.9) and 65.0 (58.1-74.3) years and -3.92 (-7.87 to -1.62) and 0.33 (-0.32 to 0.98) dB, respectively. Globally, BMO-MRW yielded better diagnostic performance than the other parameters. At 95% specificity, the sensitivity of RNFLT, BMO-HRW, and BMO-MRW was 70%, 51%, and 81%, respectively. The corresponding LR+/LR- was 14.0/0.3, 10.2/0.5, and 16.2/0.2. Sectorally, at 95% specificity, the sensitivity of RNFLT ranged from 31% to 59%, of BMO-HRW ranged from 35% to 64%, and of BMO-MRW ranged from 54% to 79%. Globally and in all sectors, BMO-MRW performed better than MRA1 or MRA2. CONCLUSIONS: The higher sensitivity at 95% specificity in early glaucoma of BMO-MRW compared with current BMO methods is significant, indicating a new structural marker for the detection and risk profiling of glaucoma.

Chauhan BC; O'Leary N; Almobarak FA; Reis AS; Yang H; Sharpe GP; Hutchison DM; Nicolela MT; Burgoyne CF

2013-03-01

292

Clinical data integration of distributed data sources using Health Level Seven (HL7) v3-RIM mapping  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Health information exchange and health information integration has become one of the top priorities for healthcare systems across institutions and hospitals. Most organizations and establishments implement health information exchange and integration in order to support meaningful information retrieval among their disparate healthcare systems. The challenges that prevent efficient health information integration for heterogeneous data sources are the lack of a common standard to support mapping across distributed data sources and the numerous and diverse healthcare domains. Health Level Seven (HL7) is a standards development organization which creates standards, but is itself not the standard. They create the Reference Information Model. RIM is developed by HL7's technical committees. It is a standardized abstract representation of HL7 data across all the domains of health care. In this article, we aim to present a design and a prototype implementation of HL7 v3-RIM mapping for information integration of distributed clinical data sources. The implementation enables the user to retrieve and search information that has been integrated using HL7 v3-RIM technology from disparate health care systems. Method and results We designed and developed a prototype implementation of HL7 v3-RIM mapping function to integrate distributed clinical data sources using R-MIM classes from HL7 v3-RIM as a global view along with a collaborative centralized web-based mapping tool to tackle the evolution of both global and local schemas. Our prototype was implemented and integrated with a Clinical Database management Systems CDMS as a plug-in module. We tested the prototype system with some use case scenarios for distributed clinical data sources across several legacy CDMS. The results have been effective in improving information delivery, completing tasks that would have been otherwise difficult to accomplish, and reducing the time required to finish tasks which are used in collaborative information retrieval and sharing with other systems. Conclusions We created a prototype implementation of HL7 v3-RIM mapping for information integration between distributed clinical data sources to promote collaborative healthcare and translational research. The prototype has effectively and efficiently ensured the accuracy of the information and knowledge extractions for systems that have been integrated

Viangteeravat Teeradache; Anyanwu Matthew N; Nagisetty Venkateswara; Kuscu Emin; Sakauye Mark; Wu Duojiao

2011-01-01

293

Imaging of the intramedullary bone infarcts and their complications; Imagerie des infarctus osteo-medullaires et de leurs complications  

Energy Technology Data Exchange (ETDEWEB)

Radiographic, CT, bone scan and MR patterns of the infarcts of the metaphyses and diaphyses of tubular bones and their main complications are presented. Bone marrow infarcts are located in the medullary cavity of long bones. They most often involve the lower limbs. They are commonly associated with necrosis of the epiphyses and have common origin. In contrast to necrosis of the epiphyses, bone infarcts may present specific complications. They are most often detected incidentally, because of their clinical latency. Radiographic and CT changes appear late, showing localized areas of increased density with irregular rims, or sharply demarcated shells of calcification. Earlier changes are demonstrated by bone scan and MRI. MR pattern is characteristic, showing an area of hyposignal on T1- and T2-weighted sequences, with irregular rims, and sometimes small areas of fat signal. Their complications include cystic formation and malignant degeneration (sarcoma and particularly malignant fibrous histiocytoma). An unusual complication, infection involving bone infarcts is also presented. (authors). 12 refs., 8 figs.

Grignon, B.; Pere, P.; Mainard, D.; Gillet, P.; Gaucher, A.; Regent, D. [Centre Hospitalier Universitaire, 54 - Nancy (France)

1995-08-01

294

Orbital change following Le Fort III advancement in syndromic craniosynostosis: quantitative evaluation of orbital volume, infra-orbital rim and globe position.  

UK PubMed Central (United Kingdom)

Patients with syndromic craniosynostosis suffering from shallow orbits due to midface hypoplasia can be treated with a Le Fort III advancement osteotomy. This study evaluates the influence of Le Fort III advancement on orbital volume, position of the infra-orbital rim and globe. In pre- and post-operative CT-scans of 18 syndromic craniosynostosis patients, segmentation of the left and right orbit was performed and the infra-orbital rim and globe were marked. By superimposing the pre- and post-operative scans and by creating a reference coordinate system, movements of the infra-orbital rim and globe were assessed. Orbital volume increased significantly, by 27.2% for the left and 28.4% for the right orbit. Significant anterior movements of the left infra-orbital rim of 12.0mm (SD 4.2) and right infra-orbital rim of 12.8mm (SD 4.9) were demonstrated. Significant medial movements of 1.7mm (SD 2.2) of the left globe and 1.5mm (SD 1.9) of the right globe were demonstrated. There was a significant correlation between anterior infra-orbital rim movement and the increase in orbital volume. Significant orbital volume increase has been demonstrated following Le Fort III advancement. The position of the infra-orbital rim was moved forward significantly, whereas the globe position remained relatively unaffected.

Nout E; van Bezooijen JS; Koudstaal MJ; Veenland JF; Hop WC; Wolvius EB; van der Wal KG

2012-04-01

295

Orbital change following Le Fort III advancement in syndromic craniosynostosis: quantitative evaluation of orbital volume, infra-orbital rim and globe position.  

Science.gov (United States)

Patients with syndromic craniosynostosis suffering from shallow orbits due to midface hypoplasia can be treated with a Le Fort III advancement osteotomy. This study evaluates the influence of Le Fort III advancement on orbital volume, position of the infra-orbital rim and globe. In pre- and post-operative CT-scans of 18 syndromic craniosynostosis patients, segmentation of the left and right orbit was performed and the infra-orbital rim and globe were marked. By superimposing the pre- and post-operative scans and by creating a reference coordinate system, movements of the infra-orbital rim and globe were assessed. Orbital volume increased significantly, by 27.2% for the left and 28.4% for the right orbit. Significant anterior movements of the left infra-orbital rim of 12.0mm (SD 4.2) and right infra-orbital rim of 12.8mm (SD 4.9) were demonstrated. Significant medial movements of 1.7mm (SD 2.2) of the left globe and 1.5mm (SD 1.9) of the right globe were demonstrated. There was a significant correlation between anterior infra-orbital rim movement and the increase in orbital volume. Significant orbital volume increase has been demonstrated following Le Fort III advancement. The position of the infra-orbital rim was moved forward significantly, whereas the globe position remained relatively unaffected. PMID:21752661

Nout, Erik; van Bezooijen, Jine S; Koudstaal, Maarten J; Veenland, Jifke F; Hop, Wim C J; Wolvius, Eppo B; van der Wal, Karel G H

2011-07-12

296

Rimmed vacuoles with beta-amyloid and tau protein deposits in the muscle of children with hereditary myopathy.  

Science.gov (United States)

We investigated whether beta-amyloid and tau protein are involved in the formation of inclusion body myositis (IBM)-like inclusions found in children with rimmed vacuoles and congenitally affected muscles. We immunostained muscle biopsy specimens from four children and one 18-year-old boy with congenital myopathy containing rimmed vacuoles and IBM-like inclusions with antibodies against beta-amyloid, tau protein and ubiquitin. Focal accumulations of both beta-amyloid and phosphorylated tau coexisted with tubulofilamentous structures in all cases. Our studies demonstrate for the first time that the full morphological phenotype of IBM including beta-amyloid and tau protein deposits may also develop in children, and that congenital, probably genetic, muscle defects may lead to abnormal protein aggregation in IBM-like inclusions. PMID:16788822

Fidzia?ska, Anna; Glinka, Zofia

2006-06-21

297

Towards a standardized representation to support data reuse: representing the ICNP semantics using the HL7 RIM.  

Science.gov (United States)

Representing nursing assessment data in a reusable manner is important as it provides a basis for decision making in patient care. In a previous study, we have extended the ICNP concept model to support representation of nursing assessment data. In this study, we evaluated its potential to support electronic documentation of nursing assessment data and HL7 conformant message generation by mapping it to the HL7 RIM. The semantics represented by the ICNP were completely related to the RIM implying that the ICNP is a good candidate terminology to encode the data with in an electronic documentation system. A few differences between the two models in representing the same semantics suggests that there is value to supporting broad ranges of semantic relations in the ICNP. PMID:19592855

Kim, Hyeoneui; Dykes, Patricia; Mar, Perry; Goldsmith, Denise; Choi, Jeeyae; Goldberg, Howard

2009-01-01

298

Towards a standardized representation to support data reuse: representing the ICNP semantics using the HL7 RIM.  

UK PubMed Central (United Kingdom)

Representing nursing assessment data in a reusable manner is important as it provides a basis for decision making in patient care. In a previous study, we have extended the ICNP concept model to support representation of nursing assessment data. In this study, we evaluated its potential to support electronic documentation of nursing assessment data and HL7 conformant message generation by mapping it to the HL7 RIM. The semantics represented by the ICNP were completely related to the RIM implying that the ICNP is a good candidate terminology to encode the data with in an electronic documentation system. A few differences between the two models in representing the same semantics suggests that there is value to supporting broad ranges of semantic relations in the ICNP.

Kim H; Dykes P; Mar P; Goldsmith D; Choi J; Goldberg H

2009-01-01

299

Conceptual Study on New Isotope Analysis Technique with Resonance Ionization Mass Spectrometry Using Inductively Coupled Plasma as an Atomic Source (ICP-RIMS)  

International Nuclear Information System (INIS)

[en] We have proposed the novel isotope analysis technique with Resonance Ionization Mass Spectrometry using Inductively Coupled Plasma as an atomic source (ICP-RIMS). Each component of ICP-RIMS is conceptually designed. We conclude that the orthogonal acceleration time-of-flight mass spectrometer (oa-TOF-MS) driven by a high-repetition-rate pulsed laser would be suitable system for ICP-RIMS. We, additionally, suggest that the first vacuum stage of the vacuum interface, which is between the sampling and skimmer cones, is desired to maintain as low pressure as possible in order to suppress the Doppler broadening and to skim the supersonic jet effectively.

2009-03-17

300

BONE SCREW  

UK PubMed Central (United Kingdom)

A bone screw having a screw member possessing a threaded section and a head and a receiving part at the head end for receiving a rod to be connected to the bone screw is provided. The receiving part has on open first bore and a substantially U-shaped cross-section having two free legs provided with a thread. Furthermore, the receiving part has a second bore on the end opposite to the first bore whose diameter is greater than that of the threaded section and smaller than that of the head. On the bottom of the first bore a seat for the head is provided. In order that the screw member can be pivoted to at least one side by an enlarged angle, the edge bounding the free end of the second bore viewed relative to the axis of the first bore is of asymmetric construction.

BIEDERMANN LUTZ; HARMS JURGEN

 
 
 
 
301

Bone Screw  

UK PubMed Central (United Kingdom)

A bone screw having a screw member possessing a threaded section and a head and a receiving part at the head end for receiving a rod to be connected to the bone screw is provided. The receiving part has on open first bore and a substantially U-shaped cross-section having two free legs provided with a thread. Furthermore, the receiving part has a second bore on the end opposite to the first bore whose diameter is greater than that of the threaded section and smaller than that of the head. On the bottom of the first bore a seat for the head is provided. In order that the screw member can be pivoted to at least one side by an enlarged angle, the edge bounding the free end of the second bore viewed relative to the axis of the first bore is of asymmetric construction.

BIEDERMANN LUTZ; HARMS JUERGEN

302

Diagnostic Value of 18F-FDG PET/CT in Comparison to Bone Scintigraphy, CT and 18F-FDG PET for the Detection of Bone Metastasis.  

UK PubMed Central (United Kingdom)

Purpose: To evaluate the diagnostic value of 18F-FDG PET/CT for detection of bone metastasis in comparison with the efficacies of 18F-FDG PET/CT, CT, 18F-FDG PET and conventional planar bone scintigraphy in a series of cancer patients. Methods: Five hundred and thirty patients who underwent both 18F-FDG PET/CT and bone scintigraphy within 1 month were retrospectively analyzed. The skeletal system was classified into 10 anatomic segments and interpreted blindly and separately. For each modality, the sensitivity, specificity, accuracy, PPV and NPV were calculated and the results were statistically analyzed. Results: Bone metastases were confirmed in 117 patients with 459 positive segments. On patient-based analysis, the sensitivity, specificity, accuracy, PPV and NPV of 18F-FDG PET/CT were significantly higher than bone scintigraphy, CT and 18F-FDG PET (P<0.05). On segment-based analysis, the sensitivity of CT, bone scintigraphy, 18F-FDG PET and 18F-FDG PET/CT were 70.4%, 89.5%, 89.1% and 97.8%, respectively (P<0.05, compared with 18F-FDG PET/CT). The overall specificity and accuracy of the four modalities were 89.1%, 91.8%, 90.3%, 98.2% and 90.3%, 90.9%, 89.8%, 98.0%, respectively (P<0.05, compared with 18F-FDG PET/CT). The PPV and NPV were 89.8%, 87.6%, 85.6%, 97.2% and 85.6%, 93.2%, 92.8%, 98.6%, respectively. Three hundred and twelve lesions or segments were presented as lytic or sclerotic changes on CT images at the corresponding sites of increased 18F-FDG uptake. In lytic or mixed lesions, the sensitivity of 18F-FDG PET/CT and 18F-FDG PET were better than bone scintigraphy, while in osteoblastic lesions bone scintigraphy had a similar performance with 18F-FDG PET/CT but better than 18F-FDG PET alone. Conclusion: Our data allow the conclusion that 18F-FDG PET/CT is superior to planar bone scintigraphy, CT or 18F-FDG PET in detecting bone metastasis. 18F-FDG PET/CT may enhance our diagnosis of tumor bone metastasis and provide more information for cancer treatment.

Liu NB; Zhu L; Li MH; Sun XR; Hu M; Huo ZW; Xu WG; Yu JM

2013-01-01

303

Bone screw  

UK PubMed Central (United Kingdom)

Bone screw with an element for transmitting the turning moment in the region of the head. The element for transmitting the turning moment is separated by an intended breaking point from a head comprising a bearing surface, and the breaking moment of this intended breaking point is smaller than the moment to be transmitted by the remainder of the screw, especially by the screw barrel.

KRANZ CURT DIPL ING

304

[Bone angioscintigraphy  

UK PubMed Central (United Kingdom)

Classical bone scintigraphy can be completed by a dynamic study of the blood supply of a previously defined anatomical region. Our protocol consists of the recording of early images in the histogram mode, centred on the selected pathological region and on the symmetrical region which acts as a control. One film is taken every 3 seconds for 3 minutes following an intravenous injection of 20 mci of Tc99m MDP into a cubital fossa vein. More limited symmetrical zones of interest are visualised on the image obtained by summation of all of the information obtained during the second minute following the arterial passage of the radioactive bolus. The curve reflecting the variation in activity for each zone of interest over these three minutes can therefore be obtained. The first part of the curve, until the first slope change, corresponds to the arterial phase (blood flow), the second part, which includes a brief venous phase, corresponds to the vasculo-tissue phase (blood pool). The value of these bone image, which allow a very detailed analysis of the topography and intensity of the uptake, is above all diagnostic, while the early, vascular images and the resulting curves are essentially of pathophysiological interest. Bone angioscintigraphy is a triple examination and one of its best applications is in reflex sympathetic dystrophy. It is able to distinguish very objectively between "hot" and "cold" forms and it can indicate the most appropriate treatment for each case and follow the effects of treatment. The other indications for bone angioscintigraphy also include Paget's disease, especially the monitoring of treatment, osteomyelitis, sarcomas and osteonecrosis.

Gaucher A; Bertrand A; Tonnel F; Hocquard C; Adolphe J; Péré P

1985-12-01

305

Recent developments in US coal exporting capability. A technical report pertinent to exporting US coal to Pacific Rim markets  

Energy Technology Data Exchange (ETDEWEB)

This technical report was prepared by the U.S. Departments of Energy and Commerce for the Energy Subgroup of the U.S.-Korean Economic Consultations. The document contains information and data addressing the technical and commercial considerations pertinent to exporting U.S. coal to Pacific Rim markets, including Korea. The purpose of the report is to provide information about ways to increase US coal exports to Korea.

1984-02-01

306

Identification of an Intermediate Methyl Carrier in the Radical S-Adenosylmethionine Methylthiotransferases RimO and MiaB.  

Science.gov (United States)

RimO and MiaB are radical S-adenosylmethionine (SAM) enzymes that catalyze the attachment of methylthio (-SCH3) groups to macromolecular substrates. RimO attaches a methylthio group at C3 of aspartate 89 of protein S12, a component of the 30S subunit of the bacterial ribosome. MiaB attaches a methylthio group at C2 of N(6)-(isopentenyl)adenosine, found at nucleotide 37 in several prokaryotic tRNAs. These two enzymes are prototypical members of a subclass of radical SAM enzymes called methylthiotransferases (MTTases). It had been assumed that the sequence of steps in MTTase reactions involves initial sulfur insertion into the organic substrate followed by capping of the inserted sulfur atom with a SAM-derived methyl group. In this work, however, we show that both RimO and MiaB from Thermotoga maritima catalyze methyl transfer from SAM to an acid/base labile acceptor on the protein in the absence of their respective macromolecular substrates. Consistent with the assignment of the acceptor as an iron-sulfur cluster, denaturation of the SAM-treated protein with acid results in production of methanethiol. When RimO or MiaB is first incubated with SAM in the absence of substrate and reductant and then incubated with excess S-adenosyl-l-[methyl-d3]methionine in the presence of substrate and reductant, production of the unlabeled product precedes production of the deuterated product, showing that the methylated species is chemically and kinetically competent to be an intermediate. PMID:23991893

Landgraf, Bradley J; Arcinas, Arthur J; Lee, Kyung-Hoon; Booker, Squire J

2013-10-03

307

Combination of surgical excision and custom designed silicon pressure splint therapy for keloids on the helical rim  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Keloids are defined as dermal fibrotic lesions which are considered an aberration of the wound healing process. Their etiology and pathogenesis are poorly understood. Different treatment modalities are described in the literature depending on the morphology and size of the keloid. We report a case of a large ear keloid on the helical rim which was successfully treated with surgery and a custom designed silicon pressure clip.

Sand Michael; Sand Daniel; Boorboor Pejman; Mann Benno; Altmeyer Peter; Hoffmann Klaus; Bechara Falk G

2007-01-01

308

Clarification of rim structure effects on properties and behaviour of LWR UO2 fuels and gadolinia doped fuels  

International Nuclear Information System (INIS)

At the peripheral region of high burnup fuel pellets, a crystallographic re-structuring is observed, commonly called the 'rim structure', which is characterized by the existence of highly dense small sub-grains, whose size is approximately 100 nm, and the accumulation of small pores with average size around 1 ?m. This restructuring can influence the fuel performance including, e.g. fission gas release behaviour, temperature, hardness and density. In order to clarify the threshold burnup and temperature of rim structure formation and fuel performances of LWR UO2 fuels and gadolinia-doped ((U,Gd)O2) fuels whose usage is increasing for higher burnup in LWR, several post irradiation examinations such as scanning electron microscope (SEM) /transmission electron microscope (TEM) observation, density measurements, hot cell annealing and thermal diffusivity measurements are done. By SEM and TEM observations, it is clarified that the microstructure evolution and the burnup and temperature threshold of rim structure formation of (U,Gd)O2 fuels is not different from that of UO2 fuels. The density change of UO2 and (U,Gd)O2 fuels is almost similar, and the irradiation temperature does not affect the density change significantly. Fission gas release behaviour can be classified by the existence of rim structure, and the release behaviour between UO2 and (U, Gd)O2 fuels is almost same. The thermal diffusivity behavior of (U, Gd)O2 fuels is similar to that of UO2 fuels, and the decrease rate of thermal diffusivity is prevented in burnup range of 50-70 MWd/kgU. (authors)

2007-10-03

309

Transcatheter closure of large atrial septal defects with deficient aortic or posterior rims using the "Greek maneuver". A multicenter study.  

UK PubMed Central (United Kingdom)

OBJECTIVES: We report a modification ("Greek maneuver") of the standard atrial septal defect (ASD) closure technique using the Amplatzer septal occluder (ASO) to facilitate closure of large ASDs with deficient aortic or posterior rims. METHODS: 185 patients (median 10.8, range 3 to 52years) with large ASDs (mean diameter 26±7mm, range 20-40mm) with a deficient aortic (134 patients) or posterior (51 patients) rim underwent catheter closure with the ASO using the "Greek maneuver" under transesophageal guidance. The Greek maneuver is applied when protrusion of the aortic edge of the deployed left disk of the device in to the right atrium is detected by echo. To circumvent this left disk is recaptured and the whole delivery system is pushed inward and leftward into the left atrium where the left disk and the 2/3 of right disk are simultaneously released. This maneuver forces the left disk to become parallel to the septum preventing the protrusion of the device into the right atrium. RESULTS: The ASO was successfully implanted and was associated with complete closure in 175/185 (95%) of the patients. There were no early or late complications related to the procedure during a follow-up period ranging from 6months to 7years. CONCLUSIONS: The "Greek maneuver" is a simple quite useful trick that facilitates closure of large ASDs associated with or without deficient aortic or posterior rims.

Thanopoulos BD; Dardas P; Ninios V; Eleftherakis N; Karanasios E

2013-05-01

310

Hand-Rim Forces and Gross Mechanical Efficiency in Asynchronous and Synchronous Wheelchair Propulsion: A Comparison.  

UK PubMed Central (United Kingdom)

To compare the force application characteristics at various push frequencies of asynchronous (ASY) and synchronous (SYN) hand-rim propulsion, 8 able-bodied participants performed a separate sub-maximal exercise test on a wheelchair roller ergometer for each propulsion mode. Each test consisted of a series of 5, 4-min exercise blocks at 1.8 m · s-1 - initially at their freely chosen frequency (FCF), followed by four counter-balanced trials at 60, 80, 120 and 140% FCF. Kinetic data was obtained using a SMARTWheel, measuring forces and moments. The gross efficiency (GE) was determined as the ratio of external work done and the total energy expended. The ASY propulsion produced higher force measures for FRES, FTAN, rate of force development & FEF (P<0.05), while there was no difference in GE values (P=0.518). In pair-matched push frequencies (ASY80:SYN60, ASY100:SYN80, ASY120:SYN100 and ASY140:SYN120), ASY propulsion forces remained significantly higher (FRES, FTAN, rate of force development & FEF P<0.05), and there was no significant effect on GE (P=0.456). Both ASY and SYN propulsion demonstrate similar trends: changes in push frequency are accompanied by changes in absolute force even without changes in the gross pattern/trend of force application, FEF or GE. Matched push frequencies continue to produce significant differences in force measures but not GE. This suggests ASY propulsion is the predominant factor in force application differences. The ASY would appear to offer a kinetic disadvantage to SYN propulsion and no physiological advantage under current testing conditions.

Lenton JP; van der Woude L; Fowler N; Nicholson G; Tolfrey K; Goosey-Tolfrey V

2013-08-01

311

[Pulmonary lesions following bone marrow graft. Study of 35 cases  

UK PubMed Central (United Kingdom)

Lung biopsy of 35 patients with interstitial pneumonitis following bone marrow transplantation (BMT) have been studied histologically, ultrastructurally and by immunofluorescence. Among infectious diseases, cytomegaloviruses (CMV) are the more frequently found, whereas Pneumocystis carinii infections are more frequently found in immunocompromised hosts without BMT. CMV infections are related to severe chronic graft-versus-host disease in allogenic or mismatched BMT. Hemorrhagic pulmonary oedema and vascular damage might be the consequence of high doses of cyclosporin A or of disseminated intravascular coagulation. Granulomatous and fibrosing lesions corresponded in 2 cases to an eosinophilic pneumonitis and in 11 cases to an "idiopathic" diffuse interstitial pneumonitis. 2 patients had concomitant diffuse lung fibrosis, sclerotic plaques of the skin and Sjögren-like syndrome. The pulmonary and cutaneous scleroses had common features in the types of collagen and in the composition of the infiltrate. Both fibroses might result from a common pathogenic mechanism related to an immunologic conflict between the lymphocytes of the graft and the cells from the host tissues.

Janin-Mercier A; Valade S; Boccon-Gibbod L; D'Agay MF; Bourges M; Devergie A; Gluckman E

1985-01-01

312

Study on Mass Discrimination Effect of Resonance Ionization Mass Spectrometry Using an Inductively Coupled Plasma as an Atomic Source (ICP-RIMS)  

International Nuclear Information System (INIS)

[en] We have proposed a novel concept of Resonance Ionization Mass Spectrometry using an Inductively Coupled Plasma as an Atomic Source (ICP-RIMS). Isotope ratio analysis using ICP-RIMS is expected to be a convenient and precise technique with high throughput. However, the mass discrimination effect caused from difference in kinetic energy of neutral atoms in ICP-RIMS is crucial for precise isotope analysis. We, therefore, investigated the atom kinetic energy distribution introduced into the laser ionization region. The mass-dependent kinetic energy was confirmed in the initial kinetic energy distributions. We preliminary estimated a mass discrimination effect caused by mass-dependent kinetic energy in ICP-RIMS for various detector sizes. We proposed that this effect can be suppressed by selecting the appropriate detector size and adopting the scanning mode of the deflecting voltage.

2009-03-17

313

Wheel chair running wheel has tire-rim, hub and disc shaped metal main body with roller edge forming gripper ring  

UK PubMed Central (United Kingdom)

The running wheel (1) has a tire-rim (2) with central hub (3) connected by a disc-shaped metal main wheel part (4) to the rim. A gripper ring to one side of the runner wheel is integrated in the main wheel body formed from a round blank by a deep-drawing method. The free end of the laterally upward bent peripheral edge (9) of the blank is rolled over towards the wheel body and forms the gripper ring (8).

HEINEMANN MICHAEL

314

Magnetic resonance imaging of bone marrow changes in Gaucher disease during enzyme replacement therapy: first German long-term results  

International Nuclear Information System (INIS)

Objective:. Since 1991, enzyme replacement therapy (ERT) has been available for patients with Gaucher disease in Germany. The aim of this study was to analyse the MR pattern of bone marrow involvement and response to ERT in Gaucher disease type I. Patients and design:. Thirty patients with Gaucher disease type I had MRI examinations prior to initiation of ERT with alglucerase/imiglucerase and during follow-up. Median MR follow-up and duration of ERT were 36 months. Coronal T1- and T2-weighted spin-echo images of the lower extremities were obtained to evaluate changes in the appearance of yellow marrow. MR images were categorized as having either a homogeneous (type A) or non-homogeneous patchy (type B) appearance of bone involvement and response to ERT was assessed by two radiologists. Results:. Overall, 19 of 30 patients (63%) showed an increased signal intensity on T1- and T2-weighted images after 36 months of ERT, consistent with partial reconversion of fatty marrow during treatment. Focal bone lesions surrounded by a low signal intensity (SI) rim did not respond to ERT, suggesting bone infarcts. Of the 11 patients with bone infarcts (low SI rim lesion), 82% had the non-homogeneous type B pattern (P=0.0021). In 86% of patients with splenectomy, bone infarcts were seen (P

2001-01-01

315

Bone marrow biopsy  

Science.gov (United States)

Biopsy - bone marrow ... A bone marrow biopsy may be done in the health care provider's office or in a hospital. The sample may be taken from the pelvic or breast bone. Sometimes, other areas are used. The health care ...

316

Food and Your Bones  

Science.gov (United States)

... You are here Home » Food and Your Bones Food and Your Bones The food that you eat ... taking multivitamins or supplements . Good-for-Your-Bones Foods Food Nutrient Dairy products such as low-fat ...

317

Bone mineral density test  

Science.gov (United States)

BMD test; Bone density test; Bone densitometry; DEXA scan; DXA; Dual-energy x-ray absorptiometry; p-DEXA ... Bone density testing can be done several different ways. The most common and accurate way uses a dual-energy ...

318

Malignant bone tumors  

International Nuclear Information System (INIS)

Clinicoroentgenologic semiotics of malignant bone tumors as well as metastatic bone tumors are presented. Diagnosis of malignant and metastatic bone tumors should be always complex, representing a result of cooperation of a physician, roentgenologist, pathoanatomist.

1984-01-01

319

TRIGGERED STAR FORMATION IN A BRIGHT-RIMMED CLOUD (BRC 5) OF IC 1805  

International Nuclear Information System (INIS)

We report recent optical, near-infrared (NIR), and millimeter observations which have revealed some new features of the bright-rimmed cloud BRC 5 associated with W4. With slitless spectroscopy, we detected 17 H? emission stars around the cloud; 4 are near the surface of the cloud, and 1 is toward IRAS 02252+6120. NIR photometry shows that the central H? emission star, together with one bright infrared source, has large NIR excesses and Class I spectral energy distributions. These two Class I objects are associated with the 2.9 mm continuum peaks and with a bipolar outflow, and are in between two separate, elongated C18O(J = 1-0) cores. The C18O cores and the two Class I sources are aligned along a line at position angle ?240°, somewhat less than perpendicular to the direction of UV radiation from the OB stars. Most of the detected H? emission stars, all T Tauri candidates, are located within ?3' of the cloud on the exciting star side. An estimate of the age of the stars based on a color-magnitude diagram suggests that these T Tauri candidates have ages of ?1 Myr or less, but are more evolved objects than the central young stellar objects. This age sequence suggests sequential star formation within the BRC 5 cloud. The 13CO(J = 1-0) emission shows three elongated structures, which indicates the asymmetric structure toward the UV incident axis. We present our exploratory simulation results by using a smoothed particle hydrodynamic code that suggests that the asymmetrical BRC 5 structure could possibly result from the evolution of a preexisting prolate molecular cloud subject to radiation-driven implosion (RDI). Our best-fit prolate cloud has an initial mass of ?400 M?, an axial ratio of ?1.7, and a semi-major axis of ?1.6 pc, pointing away from the ionization flux by an angle of 15°. The simulated cloud structure not only closely matches the observed asymmetric morphological structure of BRC 5, but also reveals the possibility of the development of two major cores at the head of BRC 5. For the first time, the possibility of forming two stars by an RDI mechanism in a BRC is investigated

2013-08-20

320

[Blood disease and bone].  

UK PubMed Central (United Kingdom)

Certain types of hematological disorders show distinct bone lesions. Multiple myeloma and primary bone lymphoma develop in the bone marrow to often cause bone destruction. These tumors stimulate osteoclastogenesis and bone resorption by enhancing RANKL expression, and suppress bone formation by inhibiting osteoblast differentiation, leading to bone destruction with rapid loss of bone. Osteosclerotic lesions are manifested in POEMS syndrome and primary myelofibrosis. Hypercalcemia is often associated with aggressive types of adult T-cell leukemia/lymphoma and multiple myeloma in advanced stages.

Abe M

2013-02-01

 
 
 
 
321

Strontium isotope analysis using resonance ionization mass spectrometry for determination of bone origin  

International Nuclear Information System (INIS)

[en] We have considered the applicability of strontium isotope analysis, using Laser Ablation-assisted Resonance Ionization Mass Spectrometry (LA-RIMS), to the determination of bone origin. We separated the uncertainty into two categories: ion counting statistics, and short-term or uncontrollable shifts of experimental conditions; only the former decreases with increasing signal intensity. Additionally, we confirmed that long-term shifts of isotope ratio in LA-RIMS can be cancelled by an internal correction method. We preliminarily estimated the precision of our technique to be 0.7% (1?) for 105 laser shots; the accuracy is also confirmed within the present uncertainty through the comparison with a reference value. (author)

2008-01-01

322

Prominin-1 localizes to the open rims of outer segment lamellae in Xenopus laevis rod and cone photoreceptors.  

UK PubMed Central (United Kingdom)

PURPOSE: Prominin-1 expresses in rod and cone photoreceptors. Mutations in the prominin-1 gene cause retinal degeneration in humans. In this study, the authors investigated the expression and subcellular localization of xlProminin-1 protein, the Xenopus laevis ortholog of prominin-1, in rod and cone photoreceptors of this frog. METHODS: Antibodies specific for xlProminin-1 were generated. Immunoblotting was used to study the expression and posttranslational processing of xlProminin-1 protein. Immunocytochemical light and electron microscopy and transgenesis were used to study the subcellular distribution of xlProminin-1. RESULTS: xlProminin-1 is expressed and is subject to posttranslational proteolytic processing in the retina, brain, and kidney. xlProminin-1 is differently expressed and localized in outer segments of rod and cone photoreceptors of X. laevis. Antibodies specific for the N or C termini of xlProminin-1 labeled the open rims of lamellae of cone outer segments (COS) and the open lamellae at the base of rod outer segments (ROS). By contrast, anti-peripherin-2/rds antibody, Xper5A11, labeled the closed rims of cone lamellae adjacent to the ciliary axoneme and the rims of the closed ROS disks. The extent of labeling of the basal ROS by anti-xlProminin-1 antibodies varied with the light cycle in this frog. The entire ROS was also faintly labeled by both antibodies, a result that contrasts with the current notion that prominin-1 localizes only to the basal ROS. CONCLUSIONS: These findings suggest that xlProminin-1 may serve as an anti-fusogenic factor in the regulation of disk morphogenesis and may help to maintain the open lamellar structure of basal ROS and COS disks in X. laevis photoreceptors.

Han Z; Anderson DW; Papermaster DS

2012-01-01

323

Prominin-1 Localizes to the Open Rims of Outer Segment Lamellae in Xenopus laevis Rod and Cone Photoreceptors  

Science.gov (United States)

Purpose. Prominin-1 expresses in rod and cone photoreceptors. Mutations in the prominin-1 gene cause retinal degeneration in humans. In this study, the authors investigated the expression and subcellular localization of xlProminin-1 protein, the Xenopus laevis ortholog of prominin-1, in rod and cone photoreceptors of this frog. Methods. Antibodies specific for xlProminin-1 were generated. Immunoblotting was used to study the expression and posttranslational processing of xlProminin-1 protein. Immunocytochemical light and electron microscopy and transgenesis were used to study the subcellular distribution of xlProminin-1. Results. xlProminin-1 is expressed and is subject to posttranslational proteolytic processing in the retina, brain, and kidney. xlProminin-1 is differently expressed and localized in outer segments of rod and cone photoreceptors of X. laevis. Antibodies specific for the N or C termini of xlProminin-1 labeled the open rims of lamellae of cone outer segments (COS) and the open lamellae at the base of rod outer segments (ROS). By contrast, anti–peripherin-2/rds antibody, Xper5A11, labeled the closed rims of cone lamellae adjacent to the ciliary axoneme and the rims of the closed ROS disks. The extent of labeling of the basal ROS by anti–xlProminin-1 antibodies varied with the light cycle in this frog. The entire ROS was also faintly labeled by both antibodies, a result that contrasts with the current notion that prominin-1 localizes only to the basal ROS. Conclusions. These findings suggest that xlProminin-1 may serve as an anti–fusogenic factor in the regulation of disk morphogenesis and may help to maintain the open lamellar structure of basal ROS and COS disks in X. laevis photoreceptors.

Han, Zhou; Anderson, David W.

2012-01-01

324

In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies  

International Nuclear Information System (INIS)

SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. In order to identify the sites where SUMOylation takes place in the cell, we developed an in situ SUMOylation assay using a semi-intact cell system and subsequently combined it with siRNA-based knockdown of nucleoporin RanBP2, also known as Nup358, which is one of the known SUMO E3 proteins. With the in situ SUMOylation assay, we found that both nuclear rim and PML bodies, besides mitotic apparatuses, are major targets for active SUMOylation. The ability to analyze possible SUMO conjugation sites would be a valuable tool to investigate where SUMO E3-like activities and/or SUMO substrates exist in the cell. Specific knockdown of RanBP2 completely abolished SUMOylation along the nuclear rim and dislocated RanGAP1 from the nuclear pore complexes. Interestingly, the loss of RanBP2 markedly reduced the number of PML bodies, in contrast to other, normal-appearing nuclear compartments including the nuclear lamina, nucleolus and chromatin, suggesting a novel link between RanBP2 and PML bodies. SUMOylation facilitated by RanBP2 at the nuclear rim may be a key step for the formation of a particular subnuclear organization. Our data imply that SUMO E3 proteins like RanBP2 facilitate spatio-temporal SUMOylation for certain nuclear structure and function

2006-05-01

325

The influence of carbonaceous surface impurities on excrescence initiation in the rimming steel/CO2/CO system  

International Nuclear Information System (INIS)

The influence of surface carbon contamination in determining the sites of excrescence growth has been studied, for the reaction of rimming steel in carbon dioxide containing 1.5% CO + 1000 ppm H2O + 10 ppm CH4 at 17.25 x 106 N m-2 and 4500C. Patterns visible in the oxide layer in the early stages of oxidation can be attributed to hydrocarbon impurities remaining on surfaces not rigorously cleaned. The impurity can accumulate at specific areas on the surface and can then accelerate oxidation such that excrescences start growing early in the normally protective stage. Surface cleaning procedures and their limitations for corrosion studies are discussed. (author)

1976-01-01

326

Computer Calculations of Eddy-Current Power Loss in Rotating Titanium Wheels and Rims in Localized Axial Magnetic Fields  

International Nuclear Information System (INIS)

[en] We have performed preliminary computer-based, transient, magnetostatic calculations of the eddy-current power loss in rotating titanium-alloy and aluminum wheels and wheel rims in the predominantly axially-directed, steady magnetic fields of two small, solenoidal coils. These calculations have been undertaken to assess the eddy-current power loss in various possible International Linear Collider (ILC) positron target wheels. They have also been done to validate the simulation code module against known results published in the literature. The commercially available software package used in these calculations is the Maxwell 3D, Version 10, Transient Module from the Ansoft Corporation

2006-01-01

327

Orthopyroxene rim growth between olivine and quartz at low temperatures (750-950°C) and low water concentration  

Science.gov (United States)

Orthopyroxene reaction rims were synthesized between polished plates of natural olivine or synthetic forsterite and quartz at 1.9 GPa and temperatures of 750-950°C. The experiments were performed in a piston-cylinder apparatus after drying the samples at 600°C. Each experiment comprised 4 or 7 quartz-olivine contacts that were positioned along a temperature gradient. As a monitor for water content in the samples, the water concentration in the two olivines was determined by FTIR before and after the experiments. The orthopyroxene layers show two different structural variants. Type one (normal layers) has very constant thickness at each contact and formed with equal growth rates at both interfaces. Type two (bulging layers) comprises more irregular areas with 3-5 times thicker rims where porosity provides evidence for the local presence of a fluid. In the bulging layers the growth rate at the olivine-orthopyroxene interface exceeds that at the quartz-orthopyroxene interface. The relative growth rates at the interfaces are in accordance with SiO2-immobile growth of the normal layers and SiO2-mobile growth of the bulging layers. The natural olivine contains about 60 wt-ppm intracrystalline water before and after experiment and took up about 20 wt-ppm water molecular adsorbed to micro- and nanocracks and -pores during the runs. The synthetic forsterite contains about 7 wt-ppm internally adsorbed molecular water before and after experiment, and during the runs took up hydrogen equivalent to 3 wt-ppm adsorbed water. The IR spectra indicate that large parts of the point defects (possibly tetrahedral) were frozen-in at the conditions of the experiments. In both olivines a new band appeared at 3,355 or 3,357 cm-1, respectively, equivalent to about 3 wt-ppm water that at the high pressure of the experiments and opx-buffered aSiO2 of the experiments might already mean water saturation of the olivines. Despite the effective drying before experiment and the absence of porosity, the bulk diffusivity derived from the rim growth rates is perfectly in line with data from water-bearing piston-cylinder experiments at higher temperatures. The bulk diffusivity during rim growth is 4 to 7 orders of magnitude higher than an extrapolation of really dry experiments to the temperature range of this study.

Milke, Ralf; Kolzer, Kornelia; Koch-Müller, Monika; Wunder, Bernd

2009-12-01

328

Computer Calculations of Eddy-Current Power Loss in Rotating Titanium Wheels and Rims in Localized Axial Magnetic Fields  

Energy Technology Data Exchange (ETDEWEB)

We have performed preliminary computer-based, transient, magnetostatic calculations of the eddy-current power loss in rotating titanium-alloy and aluminum wheels and wheel rims in the predominantly axially-directed, steady magnetic fields of two small, solenoidal coils. These calculations have been undertaken to assess the eddy-current power loss in various possible International Linear Collider (ILC) positron target wheels. They have also been done to validate the simulation code module against known results published in the literature. The commercially available software package used in these calculations is the Maxwell 3D, Version 10, Transient Module from the Ansoft Corporation.

Mayhall, D J; Stein, W; Gronberg, J B

2006-05-15

329

MRI of degenerative bone marrow lesions in experimental osteoarthritis of canine knee joints  

Energy Technology Data Exchange (ETDEWEB)

Objective. The objective of this study was to determine the value of MRI in the detection of degenerative bone marrow abnormalities in an animal osteoarthritis model. Design. In 10 dogs with experimentally induced unilateral osteoarthritis of the knee, MRI was performed using two-dimensional spin-echo (2D-SE) and three-dimensional gradient-echo (3D-GE) imaging. Contrast enhanced T1-weighted 2D-SE sequences were also obtained after injection of gadolinium-DTPA. The results were compared with the gross and histopathologic findings and with radiography. Results. Histopathologic specimens revealed 21 osteosclerotic lesions and 5 intraosseous cysts. On 2D-SE images, 24 of 26 lesions were detected, while 21 of 26 lesions were identified on 2D-GE sequences. Radiography, including conventional tomography, demonstrated 9 of 26 lesions. Regardless of the sequence weighting, all osteosclerotic lesions appeared hypointense on MRI. Signal loss in bone sclerosis resulted primarily from the reduction of intact fat marrow, the increased bone density being of secondary importance. Quantitative signal analysis allowed approximate estimation of the grade of sclerosis. On postcontrast images, sclerotic bone remained hypointense, although significant but non-specific enhancement relative to the normal fat marrow was observed. The extent of contrast enhancement did not correlate with the grade of osteosclerosis. All five cysts were readily diagnosed by MRI. Cysts displayed either central or marginal contrast enhancement within their cavities. Conclusions. MRI provides a sensitive method for the diagnosis of osteoarthritic bone abnormalities, allowing their differentiation from most non-degenerative subarticular lesions. (orig.). With 1 tab.

Nolte-Ernsting, C.C.A. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany); Adam, G. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany); Buehne, M. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany); Prescher, A. [Department of Anatomy, University of Technology, Aachen (Germany); Guenther, R.W. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany)

1996-07-01

330

Complete debridement for treatment of thoracolumbar spinal tuberculosis: a clinical curative effect observation.  

UK PubMed Central (United Kingdom)

CONCLUSIONS: Sclerotic bone, multiple cavities, and bony bridges are foci in spinal tuberculosis. Clearing tuberculous foci, sclerotic bone, multiple cavities, and bony bridges to increase the curative effect is an effective treatment method.

Jin W; Wang Q; Wang Z; Geng G

2013-10-01

331

Bone grafting: An overview  

Directory of Open Access Journals (Sweden)

Full Text Available Bone grafting is the process by which bone is transferred from a source (donor) to site (recipient). Due to trauma from accidents by speedy vehicles, falling down from height or gunshot injury particularly in human being, acquired or developmental diseases like rickets, congenital defects like abnormal bone development, wearing out because of age and overuse; lead to bone loss and to replace the loss we need the bone grafting. Osteogenesis, osteoinduction, osteoconduction, mechanical supports are the four basic mechanisms of bone graft. Bone graft can be harvested from the iliac crest, proximal tibia, proximal humerus, proximal femur, ribs and sternum. An ideal bone graft material is biologically inert, source of osteogenic, act as a mechanical support, readily available, easily adaptable in terms of size, shape, length and replaced by the host bone. Except blood, bone is grafted with greater frequency. Bone graft indicated for variety of orthopedic abnormalities, comminuted fractures, delayed unions, non-unions, arthrodesis and osteomyelitis. Bone graft can be harvested from the iliac crest, proximal tibia, proximal humerus, proximal femur, ribs and sternum. By adopting different procedure of graft preservation its antigenicity can be minimized. The concept of bone banking for obtaining bone grafts and implants is very useful for clinical application. Absolute stability require for successful incorporation. Ideal bone graft must possess osteogenic, osteoinductive and osteocon-ductive properties. Cancellous bone graft is superior to cortical bone graft. Usually autologous cancellous bone graft are used as fresh grafts where as allografts are employed as an alloimplant. None of the available type of bone grafts possesses all these properties therefore, a single type of graft cannot be recomm-ended for all types of orthopedic abnormalities. Bone grafts and implants can be selected as per clinical problems, the equipments available and preference of the surgeon. A search for ideal bone graft is on and may continue till time to time. [Vet World 2010; 3(4.000): 198-200

D. O. Joshi; P. H. Tank; H. K. Mahida; M. A. Dhami; H. S. Vedpathak; A. S. Karle

2010-01-01

332

Magnetic resonance imaging of bone marrow changes in Gaucher disease during enzyme replacement therapy: first German long-term results  

Energy Technology Data Exchange (ETDEWEB)

Objective:. Since 1991, enzyme replacement therapy (ERT) has been available for patients with Gaucher disease in Germany. The aim of this study was to analyse the MR pattern of bone marrow involvement and response to ERT in Gaucher disease type I. Patients and design:. Thirty patients with Gaucher disease type I had MRI examinations prior to initiation of ERT with alglucerase/imiglucerase and during follow-up. Median MR follow-up and duration of ERT were 36 months. Coronal T1- and T2-weighted spin-echo images of the lower extremities were obtained to evaluate changes in the appearance of yellow marrow. MR images were categorized as having either a homogeneous (type A) or non-homogeneous patchy (type B) appearance of bone involvement and response to ERT was assessed by two radiologists. Results:. Overall, 19 of 30 patients (63%) showed an increased signal intensity on T1- and T2-weighted images after 36 months of ERT, consistent with partial reconversion of fatty marrow during treatment. Focal bone lesions surrounded by a low signal intensity (SI) rim did not respond to ERT, suggesting bone infarcts. Of the 11 patients with bone infarcts (low SI rim lesion), 82% had the non-homogeneous type B pattern (P=0.0021). In 86% of patients with splenectomy, bone infarcts were seen (P<0.05). Conclusions:. MRI using T1- and T2-weighted spin-echo sequences is a valuable, non-invasive method for monitoring bone marrow response in patients receiving ERT. A non- homogeneous patchy signal intensity of bone marrow involvement correlates with the presence of bone infarcts (P=0.0021). (orig.)

Poll, L.W.; Koch, J.A.; Scherer, A.; Boerner, D.; Moedder, U. [Duesseldorf Univ. (Germany). Inst. fuer Diagnostische Radiologie; Dahl, S. vom; Niederau, C.; Haeussinger, D. [Duesseldorf Univ. (Germany). Medizinische Fakultaet; Willers, R. [Duesseldorf Univ. (Germany). Rechenzentrum

2001-09-01

333

Bone scan in rheumatology  

International Nuclear Information System (INIS)

In this chapter a revision is made concerning different uses of bone scan in rheumatic diseases. These include reflex sympathetic dystrophy, osteomyelitis, spondyloarthropaties, metabolic bone diseases, avascular bone necrosis and bone injuries due to sports. There is as well some comments concerning pediatric pathology and orthopedics. (authors). 19 refs., 9 figs

1993-01-01

334

Bone grafts in dentistry.  

UK PubMed Central (United Kingdom)

Bone grafts are used as a filler and scaffold to facilitate bone formation and promote wound healing. These grafts are bioresorbable and have no antigen-antibody reaction. These bone grafts act as a mineral reservoir which induces new bone formation.

Kumar P; Vinitha B; Fathima G

2013-06-01

335

Bone Marrow Diseases  

Science.gov (United States)

Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The ... help with blood clotting. If you have a bone marrow disease, there are problems with the stem ...

336

Bone Marrow Transplantation  

Science.gov (United States)

Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The ... clotting. If there is a problem with your bone marrow, a transplant can give you healthy new ...

337

Management of subtrochanteric femur fractures with internal fixation and recombinant human bone morphogenetic protein-7 in a patient with osteopetrosis: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Introduction Osteopetrosis is a group of conditions characterized by defects in the osteoclastic function of the bone resulting in defective bone resorption. Clinically, the condition is characterized by a dense, sclerotic, deformed bone which, despite an increased density observable by radiography, often results in an increased propensity to fracture and delayed union. Case Presentation We report the case of a 27-year-old Asian man presenting with bilateral subtrochanteric femur fractures. He had a displaced right subtrochanteric femur fracture after a low-energy fall, which was treated surgically. The second fracture that our patient endured was diagnosed as a stress fracture ten weeks later when he complained of pain in the contralateral left thigh. By that time, the right-sided fracture exhibited no radiographic evidence of healing, and when the left-sided stress fracture was being treated surgically, bone grafting with recombinant human bone morphogenetic protein-7 was also performed on the right side. Conclusion While there are no data supporting the use of bone morphogenic proteins in the management of delayed healing in patients with osteopetrosis, no other reliable osteoinductive grafting options are available to treat this condition. Both fractures in our patient healed, but based on the serial radiographic assessment it is uncertain to what degree the recombinant human bone morphogenetic protein-7 may have contributed to the successful outcome. It may have also contributed to the formation of heterotopic bone around the fracture site. Further investigation of the effectiveness and indications of bone morphogenic protein use for the management of delayed fracture healing in patients with osteopetrosis is warranted.

Golden Robert D; Rodriguez Edward K

2010-01-01

338

Determination of trace amounts of plutonium in environmental samples by RIMS using a high repetition rate solid state laser system  

Science.gov (United States)

A reliable and easy to handle high repetition rate solid state laser system has been set up for routine applications of Resonance Ionization Mass Spectrometry (RIMS). It consists of three Titanium-Sapphire (Ti:Sa) lasers pumped by one Nd:YAG laser, providing up to 3 W of tunable laser light each in a wavelength range from 725 nm to 895 nm. The isotope shifts for 238Pu to 244Pu have been measured in an efficient ionization scheme with ?1=420.76 nm, ?2=847.28 nm and ?3=767.53 nm. An overall detection efficiency of the RIMS apparatus of ?=1×10-5 is routinely reached, resulting in a detection limit of 2×106atoms (0.8 fg) of plutonium. The isotopic compositions of synthetic samples and the NIST standard reference material SRM996 were measured. The content of 238Pu to 242Pu has been determined in dust samples from the surroundings of a nuclear power plant and 244Pu was determined in urine samples for the National Radiation Protection Board (NRPB), U.K. Routine operation of plutonium ultratrace detection could thus be established. .

Grüning, C.; Huber, G.; Kratz, J. V.; Passler, G.; Trautmann, N.; Waldek, A.; Wendt, K.

2001-08-01

339

Perfil de auto-anticorpos detectados em substrato rim-estômago de rato no Hospital São Lucas da PUCRS  

Directory of Open Access Journals (Sweden)

Full Text Available Objetivo:O trabalho descreve o perfil de auto-anticorpos utilizando-se o substrato rim-estômago de rato em um centro de saúde terciário no período de um ano. Material e métodos: O estudo foi de série de casos, com dados obtidos do banco de dados do Setor de Imunologia do Laboratório de Patologia Clínica do Hospital São Lucas da PUCRS. Resultados: Em 262 pacientes (68% do sexo feminino) previamente selecionados por triagem clínica, avaliou-se o perfil de auto-anticorpos em substrato rim-estômago de rato através de imunofluorescência indireta. Anticorpos antimúsculo liso prevaleceram (31%), seguidos por anticorpos anti-reticulina (27%), anticorpos antimitocondriais (24%), anticélulas parietais gástricas (21%), anticorpos anti-" brush border" (4%) e antiLKM (liver-kidney microsome) (0,4%). A maioria dos pacientes com teste positivo para anti-corpos antimúsculo liso cursou com titulações inferiores a 1/80 (ponto de corte para hepatite auto-imune). Anticorpos anti-ribossomais não foram detectados em quaisquer pacientes. À exceção do anticorpo antiLKM (presente apenas em um caso, sexo masculino), observou-se predominância do sexo feminino nos auto-anticorpos analisados; tal predomínio, entretanto, só alcançou significância estatística para anticorpos antimitocondriais (P = 0,04). Conclusão: O achado corrobora a possível relação entre fatores genéticos e hormonais na auto-imuniadede.

Flórez, Paloma Borges et al.

2005-01-01

340

Conjunctival swabs and corneoscleral rim cultures from corneal transplantation donors as possible early indicators for posttransplant endopthalmitis.  

UK PubMed Central (United Kingdom)

PURPOSE: To determine by microbiological examinations the rate of conjunctiva and corneoscleral rim contamination of cadaver donor tissues. METHODS: A prospective review of culture results for 98 cadaver donor conjunctival swabs [mean age 76.4 ± 12.9 years (±SD)]. Transplant patients were evaluated both before and after disinfection with gentamicin. Individual parameters evaluated included detection rates of bacteria, variety of detected bacteria, time interval from donor death to tissue harvest and age of donors. RESULTS: Before disinfection, 60 out of 98 conjunctival swabs exhibited microbial growth, while only 36 out of 98 exhibited growth after disinfection (p = 0.0006). Longer intervals between death and tissue harvest were associated with higher positive microbial growth rates. Prior to disinfection, culture-positive donors (74.1 ± 13.6 years) were significantly younger than culture-negative donors (79.8 ± 10.8 years) (p = 0.024). Positive donor rim cultures were noted in 2 out of the 22 corneal transplantations. Microorganisms isolated from the corneal grafts matched those found in the conjunctiva. CONCLUSIONS: It is recommended that the corneoscleral buttons be removed as soon as possible. Cultures of conjunctival swabs collected from donors after disinfection may be useful in determining treatment for postoperative infections occurring after corneal transplantation.

Matsumoto M; Suzuma K; Miyamura N; Imamura N; Kitaoka T

2011-07-01

 
 
 
 
341

Deep Drawing for high LDR by a new Hydro-rim Forming Process with Differential Temperature- Analysis and Experiments  

International Nuclear Information System (INIS)

[en] The purpose of this study is to analyze and test a possible increase of the Limit Drawing Ratio (LDR) in Deep Drawing by Hydro-rim process (a certain subset of the classical Hydroforming) which includes the newly differential temperature effect. The idea is to facilitate the plastic flow by local heating along the flange and to cool the area where strength is needed. The suggested analysis is based on the dual bounds approach (upper and lower bounds simultaneously) using the highly versatile Johnson-Cook constitutive material model. The advantage of combined high hydraulic pressure (about 1000 bar) with relatively high blank temperature (with magnitude of about one third the melting temperature of the considered material) in the same operation is discussed. Emphasis is given to the rule of blank temperature difference (between the flange and the wall of the product) conjugate with optimal hydro rim pressure in increasing the limit drawing ratio of the products (Aluminum, Copper and various Steels)

2005-08-05

342

Basic bone radiology  

Energy Technology Data Exchange (ETDEWEB)

This clinical book surveys the skeletal system as seen through radiological imaging. It emphasizing abnormalities, disease, and trauma, and includes vital information on bones, bone growth, and the cells involved in bone pathology. It covers many bone diseases and injuries which are rarely covered in medical texts, as well as descriptions of radiologic procedures that specifically relate to the skeleton. This edition includes many illustrations, information on MR imaging and CT scanning, and discussions of osteoporosis, dysplasias, and metabolic bone disease.

Griffiths, H.J.

1987-01-01

343

Impact of eye bank lamellar tissue cutting for endothelial keratoplasty on bacterial and fungal corneoscleral donor rim cultures after corneal transplantation.  

UK PubMed Central (United Kingdom)

PURPOSE: To determine if the lamellar cut of donor tissue for endothelial keratoplasty (EK) by an eye bank facility is associated with a change in the prevalence of positive bacterial or fungal donor rim cultures after corneal transplantation. METHODS: A retrospective review was conducted of bacterial and fungal cultures of donor rims used for corneal transplantation at a tertiary eye care center from January 1, 2003, to December 31, 2008, with tissue provided by a single eye bank. The cases were divided into 2 groups. Group 1 ("no-cut") included keratoplasty procedures in which a lamellar cut was not performed. Group 2 ("precut") included EK procedures in which a 4-hour period of prewarming of tissue followed by a lamellar cut was performed in the eye bank before tissue delivery to the operating surgeon. RESULTS: There were 351 donor rim cultures in group 1 and 278 in group 2. Bacterial cultures were positive in 30 donor rims (8.5%) in group 1 and 13 (4.7%) in group 2 (P = 0.058). Positive bacterial cultures were not associated with any postoperative infections. Fungal cultures were positive in 8 donor rims (2.3%) in group 1 and 7 (2.5%) in group 2 (P = 1.0). Positive fungal cultures were associated with 2 cases (13.3%) of postoperative fungal infections. CONCLUSIONS: Corneal donor tissue can be precut for EK by trained eye bank personnel without an increased risk of bacterial or fungal contamination.

Rauen MP; Goins KM; Sutphin JE; Kitzmann AS; Schmidt GA; Wagoner MD

2012-04-01

344

Primary Rosai-Dorfman disease of bone: a clinicopathologic study of 15 cases.  

UK PubMed Central (United Kingdom)

Sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disorder of unknown etiology. Most patients present with lymph node involvement manifesting as adenopathy; however, RDD may arise primarily in a variety of extranodal sites, including bone. We report herein our experience with 15 cases of primary intraosseous RDD. The patients include 8 females and 7 males, who ranged in age from 3 to 56 (mean 27) years. The lesions arose in a variety of anatomical locations, including the tibia, femur, clavicle, skull, maxilla, calcaneus, phalanx, metacarpal, and sacrum. Radiographically, the lesions were lytic with well defined and usually sclerotic margins. Histologically, the lesions demonstrated the classic features of RDD and consisted of a mixed inflammatory infiltrate with numerous large histiocytes with abundant eosinophilic cytoplasm which exhibited emperipolesis. Some cases also contained numerous neutrophils. Immunohistochemical stains showed that the large histiocytes were S-100 positive. Follow-up information was available for 12 patients. Five patients eventually developed additional extraosseous manifestations, including testicular, lymph node, and subcutaneous lesions. One of these 5 also developed a new bony lesion within the sternum. One patient developed additional lesions within multiple bones of the hand and wrist, without extraosseous disease. One patient had stable bony lesions, whereas 5 remained disease free after treatment.

Demicco EG; Rosenberg AE; Björnsson J; Rybak LD; Unni KK; Nielsen GP

2010-09-01

345

Enfermedad de Paget en Chile: una serie de 15 pacientes/ Paget disease of bone: Report of 15 cases  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english Background: Paget disease of bone (PD) is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and methods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained dat (more) a from 15 patients with PD (ten males, eight Chilean, six European and one Asian), eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit). Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Méd Chile 2003; 131: 491-7).

González V, Gilberto; Brusco G, Francisca; Arteaga U, Eugenio; Rodríguez P, José; Jacobelli G, Sergio; Massardo V, Loreto; Ortiz M, Cristián; Contreras O, Oscar

2003-05-01

346

Reactive endosteal bone formation  

International Nuclear Information System (INIS)

The microstructure of reactive endosteal new bone was examined using undecalcified ground sections in five pathologic conditions (bone metastasis from prostate cancer in seven cases, intervertebral osteochondrosis in five, Paget disease in four, chronic suppurative osteomyelitis in two, and fracture healing in one). To determine a basic form of rapid intramembranous bone formation, fetal rat calvaria and primitive bones made in clonal osteogenic cell culture were also observed. In slow bone-forming conditions, lamellar new bone was deposited on pre-existing trabecular surface and caused trabecular thickening on radiographs. In contrast, in rapid bone-forming conditions, woven bone was deposited as spicules extending from trabecular surface so as to form new networks on intertrabecular space. This causes obscurity of trabecular margins radiographically. Reactive endosteal bone formation may be nonspecific and have a significance for assessing the virulence of underlying pathologic conditions like periosteal reactions. (orig.).

1987-01-01

347

Reactive endosteal bone formation  

Energy Technology Data Exchange (ETDEWEB)

The microstructure of reactive endosteal new bone was examined using undecalcified ground sections in five pathologic conditions (bone metastasis from prostate cancer in seven cases, intervertebral osteochondrosis in five, Paget disease in four, chronic suppurative osteomyelitis in two, and fracture healing in one). To determine a basic form of rapid intramembranous bone formation, fetal rat calvaria and primitive bones made in clonal osteogenic cell culture were also observed. In slow bone-forming conditions, lamellar new bone was deposited on pre-existing trabecular surface and caused trabecular thickening on radiographs. In contrast, in rapid bone-forming conditions, woven bone was deposited as spicules extending from trabecular surface so as to form new networks on intertrabecular space. This causes obscurity of trabecular margins radiographically. Reactive endosteal bone formation may be nonspecific and have a significance for assessing the virulence of underlying pathologic conditions like periosteal reactions.

Aoki, Jun; Yamamoto, Itsuo; Hino, Megumu; Kitamura, Nobuyasu; Sone, Teruki; Itoh, Harumi; Torizuka, Kanji

1987-10-01

348

Development of the isotope analysis technique for inorganic trace elements using laser ablation assisted resonance ionization mass spectrometry (LA-RIMS)  

International Nuclear Information System (INIS)

[en] We have developed and assessed LA-RIMS as the isotope analysis method for trace inorganic elements in agricultural products. We used magnesium isotope analysis to verify that LA-RIMS had the capability to identify the production areas with the required precision of 0.3%. We demonstrated direct measurements of trace strontium (sub ppm level) in brown rice and confirmed that the isotope analysis precision was improved through the signal intensity enhancement by increasing the ablation power and expanding the laser spot. For the present system, we estimated the strontium isotope ratio of 87Sr/86Sr to be 0.69±0.10 (14%). We concluded that the direct isotope analysis for trace inorganic elements such as strontium in brown rice using LA-RIMS had an advantage under the serious situation of isobaric interference and had sufficient capability to identify agricultural production areas. (author)

2006-01-01

349

Detailed characterisation of the rim microstructure in PWR fuels in the burn-up range 40-67 GWd/tM  

International Nuclear Information System (INIS)

[en] Fuel porosity, volume pore density and pore size distributions were determined as a function of the radial position for specimens with average burn-ups between 40 and 67 GWd/tM. In the rim region, the porosity and pore density increase exponentially towards the pellet edge, whereas the mean pore size remains constant. Accompanying the porosity increase, a band of recrystallised material (submicron-grains) is formed at the pellet edge, followed by a wide transition zone where porous grain-refined areas are mixed with the original matrix grains. Individual pores were found associated with recrystallised surroundings, extending up to a distance of 1 to 3 submicron grains from the pore surface. Accordingly, a representation of the rim material with localised recrystallisation around pores is proposed. As determined by microindentation, the mechanical strength of the rim material appeared to be increased with respect to unirradiated UO2. This improvement is supposed to be caused by grain refinement. (orig.)

1996-01-01

350

NMR spectroscopy of bone and bone substitutes  

Energy Technology Data Exchange (ETDEWEB)

High resolution solid state NMR spectroscopy appears as a powerful method for a better understanding of bone structure and bone implant. In particular it is efficient to estimate osteoformation via bioceramics bone colonization. In this work {sup 31}P, {sup 1}H NMR are used to the analysis of different type of bioceramics, to follow the transformation of calcium phosphate ceramics versus implantation time, to examine the influence of a protein. (orig.)

Legrand, A.P.; Bresson, B. [ESA, Paris (France). Lab. de Physique Quantique; Bouler, J.M. [INSERM, Nantes (France). Lab. de Recherche sur les Materiaux d' Interet Biologique

2001-07-01

351

Aneurysmal bone cyst of temporal bone.  

Science.gov (United States)

Aneurysmal bone cysts (ABC) are benign neoplasms frequently occurring in the long tubular bones. It is very rare in temporal bone. We report a case of ABC of the left temporal bone in an 8-year-old Asian boy who presented clinically with swelling over the left temporal region for 5 months. CT and MRI features were suggestive of ABC. Surgical resection was performed and on follow-up the patient was doing well. CT and MRI are the imaging modalities for proper evaluation of ABC, aiding to diagnosis and helpful in treatment planning. PMID:24014580

Ansari, Sajid; Ahmad, Kaleem; Gupta, Mukesh Kumar; Rauniyar, Raj Kumar

2013-09-07

352

Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions  

International Nuclear Information System (INIS)

[en] Aim: The aim of this study is to evaluate the value of the apparent diffusion coefficient (ADC) obtained in diffusion-weighted (DW) MR sequences for the differentiation between malignant and benign bone marrow lesions. Method: Forty-five patients with altered signal intensity vertebral bodies on conventional MR sequences were included. The cause of altered signal intensity was benign osteoporotic collapse in 16, acute neoplastic infiltration in 15, and infectious processes in 14; based on plain-film, CT, bone scintigraphy, conventional MR studies, biopsy or follow-up. All patients underwent isotropic DW MR images (multi-shot EPI, b values of 0 and 500 s/mm2). Signal intensity at DW MR images was evaluated and ADC values were calculated and compared between malignancy, benign edema and infectious spondylitis. Results: Acute malignant fractures were hyperintense compared to normal vertebral bodies on the diffusion-weighted sequence, except in one patient with sclerotic metastases. Mean ADC value from benign edema (1.9 ± 0.39 x 10-3 mm2/s) was significantly (p -3 mm2/s). Mean ADC value of infectious spondilytis (0.96 ± 0.49 x 10-3 mm2/s) was not statistically (p > 0.05) different from untreated metastasic lesions. ADC value was low (0.75 x 10-3 mm2/s) in one case of subacute benign fracture. Conclusions: ADC values are a useful complementary tool to characterize bone marrow lesions, in order to distinguish acute benign fractures from malignant or infectious bone lesions. However, ADC values are not valuable in order to differentiate malignancy from infection.

2009-01-01

353

Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions  

Energy Technology Data Exchange (ETDEWEB)

Aim: The aim of this study is to evaluate the value of the apparent diffusion coefficient (ADC) obtained in diffusion-weighted (DW) MR sequences for the differentiation between malignant and benign bone marrow lesions. Method: Forty-five patients with altered signal intensity vertebral bodies on conventional MR sequences were included. The cause of altered signal intensity was benign osteoporotic collapse in 16, acute neoplastic infiltration in 15, and infectious processes in 14; based on plain-film, CT, bone scintigraphy, conventional MR studies, biopsy or follow-up. All patients underwent isotropic DW MR images (multi-shot EPI, b values of 0 and 500 s/mm{sup 2}). Signal intensity at DW MR images was evaluated and ADC values were calculated and compared between malignancy, benign edema and infectious spondylitis. Results: Acute malignant fractures were hyperintense compared to normal vertebral bodies on the diffusion-weighted sequence, except in one patient with sclerotic metastases. Mean ADC value from benign edema (1.9 {+-} 0.39 x 10{sup -3} mm{sup 2}/s) was significantly (p < 0.0001) higher than untreated metastasic lesions (0.9 {+-} 1.3 x 10{sup -3} mm{sup 2}/s). Mean ADC value of infectious spondilytis (0.96 {+-} 0.49 x 10{sup -3} mm{sup 2}/s) was not statistically (p > 0.05) different from untreated metastasic lesions. ADC value was low (0.75 x 10{sup -3} mm{sup 2}/s) in one case of subacute benign fracture. Conclusions: ADC values are a useful complementary tool to characterize bone marrow lesions, in order to distinguish acute benign fractures from malignant or infectious bone lesions. However, ADC values are not valuable in order to differentiate malignancy from infection.

Balliu, E. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: eballiu@gmail.com; Vilanova, J.C. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: Kvilanova@comg.es; Pelaez, I. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: isapelaezrx@yahoo.es; Puig, J. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: jpuigalcantara@yahoo.es; Remollo, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sremollo@gmail.com; Barcelo, C. [Department of Computer Science and Applied Mathematics, University of Girona (Spain)], E-mail: carles.barcelo@udg.es; Barcelo, J. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: rmgirona@comg.es; Pedraza, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sapedraza@gmail.com

2009-03-15

354

Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain.  

Science.gov (United States)

Pain frequently accompanies cancer. What remains unclear is why this pain frequently becomes more severe and difficult to control with disease progression. Here we test the hypothesis that with disease progression, sensory nerve fibers that innervate the tumor-bearing tissue undergo a pathological sprouting and reorganization, which in other nonmalignant pathologies has been shown to generate and maintain chronic pain. Injection of canine prostate cancer cells into mouse bone induces a remarkable sprouting of calcitonin gene-related peptide (CGRP(+)) and neurofilament 200 kDa (NF200(+)) sensory nerve fibers. Nearly all sensory nerve fibers that undergo sprouting also coexpress tropomyosin receptor kinase A (TrkA(+)). This ectopic sprouting occurs in sensory nerve fibers that are in close proximity to colonies of prostate cancer cells, tumor-associated stromal cells and newly formed woven bone, which together form sclerotic lesions that closely mirror the osteoblastic bone lesions induced by metastatic prostate tumors in humans. Preventive treatment with an antibody that sequesters nerve growth factor (NGF), administered when the pain and bone remodeling were first observed, blocks this ectopic sprouting and attenuates cancer pain. Interestingly, reverse transcription PCR analysis indicated that the prostate cancer cells themselves do not express detectable levels of mRNA coding for NGF. This suggests that the tumor-associated stromal cells express and release NGF, which drives the pathological reorganization of nearby TrkA(+) sensory nerve fibers. Therapies that prevent this reorganization of sensory nerve fibers may provide insight into the evolving mechanisms that drive cancer pain and lead to more effective control of this chronic pain state. PMID:21048122

Jimenez-Andrade, Juan M; Bloom, Aaron P; Stake, James I; Mantyh, William G; Taylor, Reid N; Freeman, Katie T; Ghilardi, Joseph R; Kuskowski, Michael A; Mantyh, Patrick W

2010-11-01

355

Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain.  

UK PubMed Central (United Kingdom)

Pain frequently accompanies cancer. What remains unclear is why this pain frequently becomes more severe and difficult to control with disease progression. Here we test the hypothesis that with disease progression, sensory nerve fibers that innervate the tumor-bearing tissue undergo a pathological sprouting and reorganization, which in other nonmalignant pathologies has been shown to generate and maintain chronic pain. Injection of canine prostate cancer cells into mouse bone induces a remarkable sprouting of calcitonin gene-related peptide (CGRP(+)) and neurofilament 200 kDa (NF200(+)) sensory nerve fibers. Nearly all sensory nerve fibers that undergo sprouting also coexpress tropomyosin receptor kinase A (TrkA(+)). This ectopic sprouting occurs in sensory nerve fibers that are in close proximity to colonies of prostate cancer cells, tumor-associated stromal cells and newly formed woven bone, which together form sclerotic lesions that closely mirror the osteoblastic bone lesions induced by metastatic prostate tumors in humans. Preventive treatment with an antibody that sequesters nerve growth factor (NGF), administered when the pain and bone remodeling were first observed, blocks this ectopic sprouting and attenuates cancer pain. Interestingly, reverse transcription PCR analysis indicated that the prostate cancer cells themselves do not express detectable levels of mRNA coding for NGF. This suggests that the tumor-associated stromal cells express and release NGF, which drives the pathological reorganization of nearby TrkA(+) sensory nerve fibers. Therapies that prevent this reorganization of sensory nerve fibers may provide insight into the evolving mechanisms that drive cancer pain and lead to more effective control of this chronic pain state.

Jimenez-Andrade JM; Bloom AP; Stake JI; Mantyh WG; Taylor RN; Freeman KT; Ghilardi JR; Kuskowski MA; Mantyh PW

2010-11-01

356

Roentgenological semiotics of bone and bone joints pathology  

International Nuclear Information System (INIS)

Physiologic and pathologic processes in bones followed by alternations of bone structure and reflected on roentgenograms are considered and described. Most frequent reasons for roentgenodiagnosis errors in diseases of bone and bone joint apparatus are presented.

1984-01-01

357

[Bone metabolic markers for evaluation of bone metastases].  

Science.gov (United States)

Bone metabolic markers consist of bone formation markers, which are secreted from osteoblasts (BAP, OC, P1CP, P1NP) , and bone resorption markers, which are metabolites of bone type 1 collagen or secreted from osteoclasts (PYD, DPD, NTX, CTX, 1CTP, TRACP) . Those bone metabolic markers are useful for : (1) diagnosis of bone metastases, (2) follow-up during treatment of bone metastases, and (3)predicting prognosis of bone metastases. PMID:23445893

Takahashi, Shunji

2013-03-01

358

[Bone metabolic markers for evaluation of bone metastases].  

UK PubMed Central (United Kingdom)

Bone metabolic markers consist of bone formation markers, which are secreted from osteoblasts (BAP, OC, P1CP, P1NP) , and bone resorption markers, which are metabolites of bone type 1 collagen or secreted from osteoclasts (PYD, DPD, NTX, CTX, 1CTP, TRACP) . Those bone metabolic markers are useful for : (1) diagnosis of bone metastases, (2) follow-up during treatment of bone metastases, and (3)predicting prognosis of bone metastases.

Takahashi S

2013-03-01

359

A novel sclerosing skeletal dysplasia with mixed sclerosing bone dysplasia, characteristic syndromic features, and clinical and radiographic evidence of male-male transmission.  

Science.gov (United States)

We report on a father and his 4-year-old son sharing a characteristic dysmorphic facial phenotype (including hyperteleroism, prominent forehead, and wide nasal bridge), macrocephaly, hearing loss, palatal clefting, developmental delay, hypotonia and bony abnormalities including marked cranial sclerosis and sclerosis of the ribs and long bones, which evolved in severity in the son between the ages of 2 and 4 years. The father's radiographs also showed prominent coarse striations, patchy metaphyseal sclerotic plaques, markedly increased bone density and cortical thickening of long bones, and significant degenerative changes in the thoracic spine. The son has an additional history of sleep apnea resulting from multi-level airway obstruction that includes adenoid hypertrophy, lingual tonsil hypertrophy, subglottic stenosis, and supra-arytenoid tissue consistent with laryngomalacia and tracheomalacia. The clinical, radiographic, and genetic findings in father and son are consistent with a sclerosing skeletal dysplasia syndrome with similarities to mixed sclerosing bone dysplasia (MSBD) including metaphyseal plaques, osteopathia striata, and cranial sclerosis (OS-CS). This family may represent one of the first descriptions of familial inheritance and evolving phenotype in MSBD. The evidence for male-male transmission would support the existence of an autosomal mechanism of inheritance for a novel form of MSBD with characteristic syndromic features. PMID:22821701

Murphy-Ryan, Maureen; Kirmani, Salman; Thompson, Dana Mara; Binkovitz, Larry A; Thomas, Kristen B; Babovic-Vuksanovic, Dusica

2012-07-20

360

A novel sclerosing skeletal dysplasia with mixed sclerosing bone dysplasia, characteristic syndromic features, and clinical and radiographic evidence of male-male transmission.  

UK PubMed Central (United Kingdom)

We report on a father and his 4-year-old son sharing a characteristic dysmorphic facial phenotype (including hyperteleroism, prominent forehead, and wide nasal bridge), macrocephaly, hearing loss, palatal clefting, developmental delay, hypotonia and bony abnormalities including marked cranial sclerosis and sclerosis of the ribs and long bones, which evolved in severity in the son between the ages of 2 and 4 years. The father's radiographs also showed prominent coarse striations, patchy metaphyseal sclerotic plaques, markedly increased bone density and cortical thickening of long bones, and significant degenerative changes in the thoracic spine. The son has an additional history of sleep apnea resulting from multi-level airway obstruction that includes adenoid hypertrophy, lingual tonsil hypertrophy, subglottic stenosis, and supra-arytenoid tissue consistent with laryngomalacia and tracheomalacia. The clinical, radiographic, and genetic findings in father and son are consistent with a sclerosing skeletal dysplasia syndrome with similarities to mixed sclerosing bone dysplasia (MSBD) including metaphyseal plaques, osteopathia striata, and cranial sclerosis (OS-CS). This family may represent one of the first descriptions of familial inheritance and evolving phenotype in MSBD. The evidence for male-male transmission would support the existence of an autosomal mechanism of inheritance for a novel form of MSBD with characteristic syndromic features.

Murphy-Ryan M; Kirmani S; Thompson DM; Binkovitz LA; Thomas KB; Babovic-Vuksanovic D

2012-09-01

 
 
 
 
361

Composite implant of native bovine bone morphogenetic protein (BMP), collagen carrier and biocoral in the treatment of resistant ulnar nonunions: report of five preliminary cases.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Bone morphogenetic protein (BMP) has been shown to induce bone formation and union in long bone defects and nonunions. There are, however, no previous reports of BMP being used for ulnar nonunions. We report on five cases of resistant ulnar nonunions treated with a composite implant consisting of a biocoral frame, collagen carrier, and bovine BMP. MATERIALS AND METHODS: Four diaphyseal and one olecranon ulnar nonunions were treated using BMP/coral implant combined with internal fixation. Additional autografting was used in three cases. All of the cases were challenging in their own ways: Three of the patients had been operated on earlier for their nonunion without success, one had a 40 mm bone loss, and one had a 9-month-old untreated olecranon fracture. After excision of the sclerotic surfaces of the nonunion, the gap was filled with autograft and a composite implant containing BMP. Fixation was done with a compression plate in the diaphyseal nonunions and with a tension band in the olecranon nonunion. RESULTS: Solid union was achieved in all five cases. No infections or other adverse effects were encountered. CONCLUSION: These preliminary results suggest that BMP-containing implants might be a feasible alternative or superior to autografting in the treatment of resistant ulnar nonunions.

Kujala S; Raatikainen T; Ryhänen J; Kaarela O; Jalovaara P

2004-01-01

362

A Data Model Based on Semantically Enhanced HL7 RIM for Sharing Patient Data of Breast Cancer Clinical Trials.  

UK PubMed Central (United Kingdom)

Breast cancer clinical trial researchers have to handle heterogeneous data coming from different data sources, overloading biomedical researchers when they need to query data for retrospective analysis. This paper presents the Common Data Model (CDM) proposed within the INTEGRATE EU project to homogenize data coming from different clinical partners. This CDM is based on the Reference Information Model (RIM) from the Health Level 7 (HL7) version 3. Semantic capabilities through an SPARQL endpoint were also required to ensure the sustainability of the platform. For the SPARQL endpoint implementation, a comparison has been carried out between a Relational SQL database + D2R and a RDF database. The results show that the first option can store all clinical data received from institutions participating in the project with a better performance. It has been also evaluated by the EU Commission within a patient recruitment demonstrator.

Moratilla JM; Alonso-Calvo R; Molina-Vaquero G; Paraiso-Medina S; Perez-Rey D; Maojo V

2013-01-01

363

Tumor fibroso solitário do rim: descrição de caso Solitary fibrous tumor of the kidney: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Apresentamos um caso de tumor renal num paciente de 27 anos de idade, que foi submetido a estudo de imagem por tomografia computadorizada e ressonância magnética. As características radiológicas da massa induziam para um diagnóstico de tumor renal maligno de origem intraparanquimatosa. No entanto, o estudo histopatológico revelou tumor fibroso solitário benigno originário da pelve e porção calicial do rim direito.We present a case of a 27-year-old male patient submitted to computed tomography and magnetic resonance imaging for the evaluation of a renal tumor. The radiological features of the mass suggested the diagnosis of a malignant renal tumor of parenchymatous origin. However, the histological findings proved to be a benign solitary fibrous tumor within the pelvis and caliceal portion of the right kidney.

Giovani Rodrigues Batista; Giuseppe D'Ippolito; Jacob Szejnfeld; Suzan Menasce; Marcos Tadeu l. Fischman; Renato Lima de Moraes Junior

2005-01-01

364

Structure and function of Escherichia coli RimK, an ATP-grasp fold, l-glutamyl ligase enzyme.  

UK PubMed Central (United Kingdom)

We report herein the crystal structure of Escherichia coli RimK at a resolution of 2.85 Å, an enzyme that catalyzes the post-translational addition of up to 15 C-terminal glutamate residues to ribosomal protein S6. The structure belongs to the ATP-grasp superfamily and is organized as a tetramer, consistent with gel filtration analysis. Each subunit consists of three distinct structural domains and the active site is located in the cleft between these domains. The catalytic reaction appears to occur at the junction between the three domains as ATP binds between the B and C domains, and other substrates bind nearby.Proteins 2013; 81:1847-1854. © 2013 Wiley Periodicals, Inc.

Zhao G; Jin Z; Wang Y; Allewell NM; Tuchman M; Shi D

2013-10-01

365

Regional multipliers: A user handbook for the regional input-output modeling system (RIMS II). Second edition  

Energy Technology Data Exchange (ETDEWEB)

The handbook contains updated tables of regional input-output multipliers by industry, for output, earnings, and employment, for all States and the District of Columbia. Multipliers are shown on a direct-effect basis as well as on a final-demand basis. Methodological changes have improved the accuracy of the multipliers. Regional Input-Output Modeling System (RIMS II) multipliers have been used for estimating the regional economic and industrial impacts of: opening or closing military bases, tourist expenditures, new energy facilities, energy conservation, offshore drilling, opening or closing manufacturing plants, and new airport or port facilities. The handbook explains how to obtain multipliers for any of the more than 500 industries in the Bureau of Economic Analysis (BEA's) national input-output table in any region composed of one or more of the Nations's more than 3,100 counties and county equivalents.

Beemiller, R.M.; Friedenberg, H.L.

1992-05-01

366

Triazole linked lower rim glycosyl appended 1,3-calix[4]arene conjugates: Synthesis, characterization, and their interaction with jacalin.  

UK PubMed Central (United Kingdom)

Triazole linked lower rim galactosyl and lactosyl appended calix[4]arene conjugates have been synthesized by 1,3 dipolar addition of glycosyl azide and calix[4]arene alkyne. All these conjugates were characterized by (1)H and (13)C NMR, IR and mass spectrometry. Interaction of amino acids with the galactosyl conjugate of calix[4]arene (5) was studied using absorption and (1)H NMR techniques. Absorption studies showed that Trp interacts with triazole ring of 5. This was further confirmed by (1)H NMR study which showed an upfield shift in the triazole proton of 5 upon titrating with Trp. The preliminary studies of interaction of these conjugates with Jacalin were demonstrated by fluorescence and circular dichroism (CD) spectroscopy techniques.

Chinta JP; Rao CP

2013-03-01

367

Design, Implementation, Simulation, and Visualization of a Highly Efficient RIM Microfluidic Mixer for Rapid Freeze-Quench of Biological Samples  

Science.gov (United States)

Rapid freeze-quench (RFQ) trapping of short-lived reaction intermediates for spectroscopic study plays an important role in the characterization of biological reactions. Recently there has been considerable effort to achieve submillisecond reaction deadtimes. We present here a new, robust, high-velocity microfluidic mixer that enables such rapid freeze-quenching. It is a based on the mixing method of two impinging jets commonly used in reaction injection molding (RIM) of plastics. This method achieves efficient mixing by inducing chaotic flow at relatively low Reynolds numbers (Re =140). We present the first mathematical simulation and microscopic visualization of mixing in such RFQ micromixers, the results of which show that the impinging solutions efficiently mix within the mixing chamber. These tests, along with a practical demonstration in a RFQ setup that involves copper wheels, show this new mixer can in practice provide reaction deadtimes as low as 100 microseconds.

Schmidt, Bryan; Mahmud, Goher; Soh, Siowling; Kim, Sun Hee; Page, Taylor; O'Halloran, Thomas V.; Grzybowski, Bartosz A.; Hoffman, Brian M.

2011-01-01

368

Structure and function of Escherichia coli RimK, an ATP-grasp fold, l-glutamyl ligase enzyme.  

Science.gov (United States)

We report herein the crystal structure of Escherichia coli RimK at a resolution of 2.85 Å, an enzyme that catalyzes the post-translational addition of up to 15 C-terminal glutamate residues to ribosomal protein S6. The structure belongs to the ATP-grasp superfamily and is organized as a tetramer, consistent with gel filtration analysis. Each subunit consists of three distinct structural domains and the active site is located in the cleft between these domains. The catalytic reaction appears to occur at the junction between the three domains as ATP binds between the B and C domains, and other substrates bind nearby.Proteins 2013; 81:1847-1854. © 2013 Wiley Periodicals, Inc. PMID:23609986

Zhao, Gengxiang; Jin, Zhongmin; Wang, Yanli; Allewell, Norma M; Tuchman, Mendel; Shi, Dashuang

2013-07-22

369

RC-IAL: linhagem celular contínua de rim de coelho - características e substrato para replicação de vírus  

Directory of Open Access Journals (Sweden)

Full Text Available Uma linhagem celular de rim de coelho (denominada RC-IAL), que foi isolada em 1976, e que atualmente está na 150ª passagem, teve suas características analisadas. As células apresentaram morfologia semelhante aos fibroblastos desde o início de seu cultivo. A proporção de crescimento celular não se alterou desde seu isolamento, com uma eficiência de clonagem ao redor de 9%. A linhagem mostrou crescimento dependente de ancoragem, e a análise cromossômica apresentou o número modal da espécie com pequenas variações para mais ou menos um cromossomo, resultando uma somatória de 50%. Sua espécie de origem foi comprovada através da reação de imunofluorescência indireta e a susceptibilidade da linhagem a alguns vírus, com demonstração do efeito citopático, foi verificada com os vírus da vacínia, cowpox, herpes simples tipo 1 e 2 e da rubéola. Esse substrato celular está livre de contaminantes, satisfazendo assim, as condições para seu uso em trabalhos científicos, principalmente os relacionadas à saúde pública.

Cruz Aurea Silveira; Figueiredo Cristina Adelaide; Barbosa Maria Luisa; Martinez Clelia Helena de O.; Salles-Gomes Luís Florêncio

1992-01-01

370

[Sector-based analysis of the distribution of the neuroretinal rim by confocal scanning laser in the diagnosis of glaucoma].  

UK PubMed Central (United Kingdom)

PURPOSE: To evaluate the diagnostic ability of the Moorfields regression analysis (MRA; neuroretinal rim sector-based analysis) by means of confocal scanning laser. METHODS: 200 eyes were included in this study: 101 normal subjects and 99 glaucoma patients (standard automated perimetry with glaucomatous defects -MD or CPSD with p<0.02 or a cluster of three or more points with p<0.05 or a cluster of two or more points with p<0.01 or abnormal Glaucoma Hemifield Test). All subjects underwent a full ophthalmic evaluation, visual field evaluation by means of a Humphrey Field Analyzer, 24-2 full threshold strategy, and optic disc topography by Heidelberg retina tomograph (HRT-II). The outcome parameters were sensitivity and specificity of the MRA for each sector. RESULTS: The highest sensitivity in detecting structural defects based on MRA (p<0.05) was observed in the nasal-superior sector (48%) and nasal-inferior sector (45%); however the highest specificity was found in the temporal-superior (98%) and inferior (98%) sectors. The highest sensitivity for MRA (p<0.01) was found in the temporal-inferior sector (31%) and nasal-superior sector (30%) while the temporal-superior and inferior-sectors showed the highest specificity (100%). The diagnosis of glaucoma based on the presence of any sector alteration showed sensitivity figures of 67% with p<0.05 and 46% with p<0.01 and specificity values of 84% with p<0.05 and 96% with p<0.01. CONCLUSIONS: The analysis of the distribution of the neuroretinal rim by means of HRT-II contributes effectively to the diagnosis of glaucoma based on perimetry in a sample derived from a Spanish population.

Pueyo V; Larrosa JM; Polo V; Pérez-Iñigo A; Ferreras A; Honrubia FM

2006-03-01

371

Endothelial cell density before and after the preparation of corneal lamellae for Descemet membrane endothelial keratoplasty with a stromal rim.  

UK PubMed Central (United Kingdom)

PURPOSE: To assess the endothelial cell density before and after the preparation of precut posterior corneal lamellae for Descemet membrane (DM) endothelial keratoplasty with a stromal rim with the aim of standardizing this new technique and establishing the parameters of corneas intended for manual preparation under the conditions of an ocular tissue bank. METHODS: Two groups of corneoscleral buttons were used to prepare lamellae consisting of a central zone of endothelium-DM surrounded by a supporting peripheral stromal rim. Group 1 contained 12 corneas with a live endothelial cell density (LECD) of 2500 cells per square millimeter or more. Group 2 contained 10 corneas with a density of 2500 cells per square millimeter or less. The preparation was performed manually using an artificial anterior chamber. The endothelial cell density (ECD) and the percentage of dead cells were assessed before and immediately after preparation and after 48 hours of organ culture storage at 31°C. RESULTS: Immediately after preparation, on average, 4.9% and 5.2% of dead cells were found in group 1 and group 2, respectively. After 48 hours of storage, the percentage decreased significantly in both the groups. There was no significant decrease in the ECD 48 hours after preparation in group 1; however, there was a significant decrease in group 2. The amount of tissue wasted during preparation was 24%. CONCLUSIONS: The decrease in ECD is dependent on the initial values: the cell loss is less in corneas with higher original densities. We suggest that the minimal acceptable LECD of lamellae should be 2500 cells per square millimeter.

Krabcova I; Studeny P; Jirsova K

2011-12-01

372

Bone resorption, metastasis, and diphosphonates  

Energy Technology Data Exchange (ETDEWEB)

This book contains 17 selections. Some of the titles are: Radiotherapy of Bone Lesions; Methodological Problems; Treatment of Bone Metastasis with Antiresorptive Drugs; Control of Bone Cancer Pain; and Chemotherapy of Bone Metastases.

Garattini, S.

1985-01-01

373

Bone X-Ray (Radiography)  

Science.gov (United States)

Bone X-ray (Radiography) Play Video Clip (00:04:40) Your Radiologist Explains Bone X-ray What ... limitations of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is ...

374

Smoking and Bone Health  

Science.gov (United States)

... supported by your browser. Home Bone Basics Lifestyle Smoking and Bone Health Publication available in: PDF (217 ... Overtraining Risks for Women Oral Health Partner Resources Smoking: It’s Never Too Late to Stop (NIA)

375

Autoinflammatory bone disorders.  

UK PubMed Central (United Kingdom)

Autoinflammatory bone disorders are characterized by chronic non-infectious osteomyelitis and inflammation-induced bone resorption and result from aberrant activation of the innate immune system. Sporadic chronic non-bacterial osteomyelitis (CNO) is the most common disease subtype. The clinical picture is highly variable and the exact underlying pathophysiology remains to be determined. Recently, novel insights in the pathophysiology of sterile bone inflammation have been gathered by analyzing patients with rare, monogenic inflammatory diseases. In this overview CNO and Majeed syndrome, cherubism, hypophosphatasia and primary hypertrophic osteoarthropathy will be discussed. For the latter four disorders, a genetic cause affecting bone metabolism and leading to chronic bone inflammation has been described. The exact pathophysiology of CNO remains to be determined. Insights from monogenic autoinflammatory bone diseases and the identification of distinct inflammatory pathways may help to understand the pathogenesis of bone inflammation and inflammation-induced bone resorption in more common diseases.

Morbach H; Hedrich CM; Beer M; Girschick HJ

2013-06-01

376

Bone Density Test  

Science.gov (United States)

Bone density test Basics In-Depth Multimedia Resources Reprints A single copy of this article may be reprinted for personal, noncommercial use only. Bone density test By Mayo Clinic staff Original Article: http:// ...

377

Tumor metastasis to bone  

Science.gov (United States)

Establishment of skeletal metastasis involves bidirectional interactions between the tumor cell and the cellular elements in the bone microenvironment. A better understanding of the pathophysiology of bone metastasis will be critical in developing the means to prevent bone metastasis or inhibit its progression. The receptor activator of nuclear factor-?B (RANK)/RANK ligand pathway has emerged as the key pathway regulating osteolysis in skeletal metastasis. A number of candidate factors, including the Wnt (wingless int) proteins, endothelin-1, and bone morphogenetic proteins, have been implicated in the establishment of osteoblastic metastasis. The complex nature of tumor-bone microenvironment interactions and the presence of multiple pathways that lead to bone metastasis suggests that simultaneous targeting of these pathways in the metastatic cascade are required for effective treatment. This review discusses current understanding of the pathophysiologic mechanisms that underlie the establishment of bone metastasis and potential molecular therapeutic strategies for prevention and treatment of bone metastasis.

Virk, Mandeep S; Lieberman, Jay R

2007-01-01

378

Genetics of Bone Density  

Science.gov (United States)

... of Social Stress April 23, 2012 Genetics of Bone Density A new study linked 32 novel genetic regions ... explained a small fraction of the variation in bone density, and none were shown to influence the risk ...

379

Eating Disorders and Bone.  

UK PubMed Central (United Kingdom)

Low bone mineral density (BMD) is a frequent and often-overlooked consequence of eating disorders, in particular anorexia nervosa and eating disorders associated with the female athlete triad. The causes of low BMD are multifactorial and include low peak bone mass accrual, accelerated bone resorption, and changes in bone microarchitecture. Early diagnosis and interventions focused on nutritional rehabilitation and weight gain reduce the risk of further BMD deficits and fractures.

Tomlinson D; Morgan SL

2013-10-01

380

Aneurysmal bone cyst of the frontal bone  

Directory of Open Access Journals (Sweden)

Full Text Available Background. Aneurysmal bone cyst (ABC) is a benign, expansive, osteolytic lesion that mainly occurs in young people, and involves the skull bones only exceptionally. The origin of ABC is controversial: secondary reactive bone lesion, or primary disease that represents an independent nosological entity. Blunt head trauma was suggested as a possible etiological factor. Case report. A case of a 19-year old man with primary ABC of the right frontal bone was reported. The lesion was totally excised through frontal craniotomy, and the skull bone defect primarily reconstructed with an acrilate cranioplasty. Five years after the surgery, the patient was without signs of local recurrence. Conclusion. Clinical and neuroradiological presentation of the skull ABC was not specific. Pathohistology confirmed the diagnosis. Total excision was the treatment of choice.

Peri? Predrag; Anti? Branislav; Radi?-Tasi? Olga

2005-01-01

 
 
 
 
381

Fracture mechanics of bone.  

UK PubMed Central (United Kingdom)

This paper reviews the progress that has been made in applying the principles of fracture mechanics to the topic of fracture of long bones. Prediction of loading conditions which result in the propagation of fractures in bones has been of interest to the field of trauma biomechanics and orthopedics for over one hundred years. Independent verifications, by various investigators, of bone fracture mechanics parameters are reviewed and investigations of the effects of bone density and specimen thickness on the critical fracture mechanics parameters and of other factors such as critical crack length and plastic zone size in bovine femoral bone, and the effects of crack velocity on fracture mechanics parameters in bovine tibial bone are discussed. It took over ten years for the techniques of bone fracture mechanics to be applied to human compact bone, due primarily to geometric constraints from the smaller size of human bones. That work will be reviewed along with other continuing work to define the orientation dependence of the fracture mechanics parameters in bone and to refine the experimental techniques needed to overcome the geometric constraints of specimen size. A discussion is included of work still needed to determine fracture mechanics parameters for transverse and longitudinal crack propagation in human bone and to establish the effects of age on those parameters. Finally, a discussion will be given of how this knowledge needs to be extended to allow prediction of whole bone fracture from external loading to aid in the design of protective systems.

Melvin JW

1993-11-01

382

Bone Density Scan  

Science.gov (United States)

• Overview Bone density scanning, also called dual-energy x-ray absorptiometry (DXA) or bone densitometry , is an enhanced form of x- ... is today's established standard for measuring bone mineral density (BMD). An x-ray (radiograph) is a noninvasive ...

383

Tumor metastasis to bone  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Establishment of skeletal metastasis involves bidirectional interactions between the tumor cell and the cellular elements in the bone microenvironment. A better understanding of the pathophysiology of bone metastasis will be critical in developing the means to prevent bone metastasis or inhibit its ...

Virk, Mandeep S; Lieberman, Jay R

384

Bone-grafting device for repairing bone defect  

UK PubMed Central (United Kingdom)

The utility model belongs to the fields of bone science and medical appliance and particularly relates to a bone-grafting device for clinically repairing the bone defect. The best and commonest method recognized home and abroad for repairing the bone defect caused by trauma, inflammation, bone tumor and other pathological changes is to transplant autogenous bone, wherein the autogenous bone is mainly from chiselled autogenlc ilium and bone substances bit from an operation process the bone substances are bit into particulates when the bone substances are transplanted and the bone particulates are transplanted into the position of the bone defect one by one, but the method wastes time and labor, the bone granulates are easily scattered and leaked to other places, and deep bone grafting has the defects particularly, such as bone grafting of vertebral intertransverse process fusion or bone grafting of bone cystic lesion. Regarding to the defects, the utility model develops the clinical bone-grafting device which is convenient for use, wherein the bone granulates are filled in the device, are compacted to prevent scattering, and are integrally pushed to the area of the bone defect in an alignment mode. The bone-grafting device is made of a medical polymer transparent material, has different types corresponding to the volumes of the bone-grafting devices, and comprises a detachable movable buckled coping on the top, a bone-grafting device cylinder with volume scales in the middle, and a detachable piston push rod device on the tail part.

XINMING YANG; YU SHI

385

Composite correction of a unilateral cleft lip nose deformity and alveolar bone grafting  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Managing the cleft lip nasal deformity has always been a challenge. Even now, there is no single established universally accepted method of correction. The open alveolar gap and the ipsilateral hypoplastic maxilla are two major problems in achieving consistently good results in a cleft lip nasal deformity. In our study, after first assuring the orthodontic realignment of maxillary arches, we combined bone grafting in the alveolar gap and along the pyriform margin, with a formal open rhinoplasty approach. Methods: All the patients underwent orthodontic treatment for preparation of the alveolar bone grafting. During the process of alveolar bone graft, a strip of septal cartilage graft was harvested from the lower border of the septum which also helps to correct the septal deviation. The cancellous bone graft harvested from the iliac crest was used to fill the alveolar gap and placed along the pyriform margin to gain symmetry. Through open rhinoplasty along the alar rim and additionally using Potter?s incision extending to the lateral vestibule, the lateral crura of the alar cartilage on the cleft side was released from its lateral attachment and advanced medially as a chondromucosal flap in a V-Y fashion, in order to bring the cleft-side alar cartilage into a normal symmetric position. The harvested septal cartilage graft was used as a columellar strut. The cleft nostril sill was narrowed by a Y-V advancement at the alar base and any overhanging alar rim skin was carefully excised to achieve symmetry. Results: The results of this composite approach were encouraging in our series of 15 patients with no additional morbidity and a better symmetry of the nose and airway especially in the adolescent age group. Conclusion: This concept of simultaneous approach when appropriate for nasal correction at the time of alveolar bone grafting showed an encouraging aesthetic and functional outcome.

Mokal Nitin; Prabhash; Kale Chintamani

2009-01-01

386

Multiple soft tissue aneurysmal cysts: An occurrence after resection of primary aneurysmal bone cyst of fibula  

Directory of Open Access Journals (Sweden)

Full Text Available We report a case of multiple extraosseous aneurysmal cysts occurring in the muscle and subcutaneous plane of postero-lateral aspects of the upper right leg. They appeared about 15 months after resection of aneurysmal bone cyst of the upper end of the fibula. They varied in size from 2 cm to 5 cm. Radiologically they were well-defined lesions with central septate areas surrounded by a rim of calcification. Histologically they showed central cystic spaces separated by septa consisting of fibroblasts, osteoclast type of giant cells and reactive woven bone. Thus they showed histological similarity with aneurysmal bone cysts, but did not show any connection with the bone. Only very few examples of aneurysmal cysts of soft tissue had been described in the past one decade and they were reported in various locations including rare sites such as arterial wall and larynx. Recent cytogenetic analyses have shown abnormalities involving 17p11-13 and/or 16q22 in both osseous and extraosseous aneurysmal cysts indicating its probable neoplastic nature. Our case had unique features like multiplicity and occurrence after resection of primary aneurysmal bone cyst of the underlying bone.

Karkuzhali P; Bhattacharyya Mahuya; Sumitha P

2007-01-01

387

Post-translational modification of ribosomal proteins: structural and functional characterization of RimO from Thermotoga maritima, a radical S-adenosylmethionine methylthiotransferase.  

UK PubMed Central (United Kingdom)

Post-translational modifications of ribosomal proteins are important for the accuracy of the decoding machinery. A recent in vivo study has shown that the rimO gene is involved in generation of the 3-methylthio derivative of residue Asp-89 in ribosomal protein S12 (Anton, B. P., Saleh, L., Benner, J. S., Raleigh, E. A., Kasif, S., and Roberts, R. J. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 1826-1831). This reaction is formally identical to that catalyzed by MiaB on the C2 of adenosine 37 near the anticodon of several tRNAs. We present spectroscopic evidence that Thermotoga maritima RimO, like MiaB, contains two [4Fe-4S] centers, one presumably bound to three invariant cysteines in the central radical S-adenosylmethionine (AdoMet) domain and the other to three invariant cysteines in the N-terminal UPF0004 domain. We demonstrate that holo-RimO can specifically methylthiolate the aspartate residue of a 20-mer peptide derived from S12, yielding a mixture of mono- and bismethylthio derivatives. Finally, we present the 2.0 A crystal structure of the central radical AdoMet and the C-terminal TRAM (tRNA methyltransferase 2 and MiaB) domains in apo-RimO. Although the core of the open triose-phosphate isomerase (TIM) barrel of the radical AdoMet domain was conserved, RimO showed differences in domain organization compared with other radical AdoMet enzymes. The unusually acidic TRAM domain, likely to bind the basic S12 protein, is located at the distal edge of the radical AdoMet domain. The basic S12 protein substrate is likely to bind RimO through interactions with both the TRAM domain and the concave surface of the incomplete TIM barrel. These biophysical results provide a foundation for understanding the mechanism of methylthioation by radical AdoMet enzymes in the MiaB/RimO family.

Arragain S; Garcia-Serres R; Blondin G; Douki T; Clemancey M; Latour JM; Forouhar F; Neely H; Montelione GT; Hunt JF; Mulliez E; Fontecave M; Atta M

2010-02-01

388

Post-translational Modification of Ribosomal Proteins - Structural and Functional Characterization of RimO from Thermotoga Maritima, A Radiacal S-Adenosylmethionine Methylthiotransferase  

Energy Technology Data Exchange (ETDEWEB)

Post-translational modifications of ribosomal proteins are important for the accuracy of the decoding machinery. A recent in vivo study has shown that the rimO gene is involved in generation of the 3-methylthio derivative of residue Asp-89 in ribosomal protein S12 (Anton, B. P., Saleh, L., Benner, J. S., Raleigh, E. A., Kasif, S., and Roberts, R. J. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 1826-1831). This reaction is formally identical to that catalyzed by MiaB on the C2 of adenosine 37 near the anticodon of several tRNAs. We present spectroscopic evidence that Thermotoga maritima RimO, like MiaB, contains two [4Fe-4S] centers, one presumably bound to three invariant cysteines in the central radical S-adenosylmethionine (AdoMet) domain and the other to three invariant cysteines in the N-terminal UPF0004 domain. We demonstrate that holo-RimO can specifically methylthiolate the aspartate residue of a 20-mer peptide derived from S12, yielding a mixture of mono- and bismethylthio derivatives. Finally, we present the 2.0 {angstrom} crystal structure of the central radical AdoMet and the C-terminal TRAM (tRNA methyltransferase 2 and MiaB) domains in apo-RimO. Although the core of the open triose-phosphate isomerase (TIM) barrel of the radical AdoMet domain was conserved, RimO showed differences in domain organization compared with other radical AdoMet enzymes. The unusually acidic TRAM domain, likely to bind the basic S12 protein, is located at the distal edge of the radical AdoMet domain. The basic S12 protein substrate is likely to bind RimO through interactions with both the TRAM domain and the concave surface of the incomplete TIM barrel. These biophysical results provide a foundation for understanding the mechanism of methylthioation by radical AdoMet enzymes in the MiaB/RimO family.

Arragain, S.; Garcia-Serres, R; Blondin, G; Douki, T; Clemancey, M; Latour, J; Forouhar, F; Neely, H; Montelione, G; et. al.

2010-01-01

389

Method for fusing bone  

Energy Technology Data Exchange (ETDEWEB)

Method for fusing bone. The present invention is a method for joining hard tissue which includes chemically removing the mineral matrix from a thin layer of the surfaces to be joined, placing the two bones together, and heating the joint using electromagnetic radiation. The goal of the method is not to produce a full-strength weld of, for example, a cortical bone of the tibia, but rather to produce a weld of sufficient strength to hold the bone halves in registration while either external fixative devices are applied to stabilize the bone segments, or normal healing processes restore full strength to the tibia.

Mourant, Judith R. (Los Alamos, NM); Anderson, Gerhard D. (Velarde, NM); Bigio, Irving J. (Los Alamos, NM); Johnson, Tamara M. (Los Alamos, NM)

1996-01-01

390

Tratamento conservador do rim displásico multicístico: curso clínico e ultra-sonográfico Conservative management of multicystic dysplastic kidney: clinical course and ultrasound outcome  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVO: Descrever o curso clínico e a evolução ultra-sonográfica de pacientes com rim displásico multicístico tratados conservadoramente. MÉTODOS: Foram incluídas no estudo 53 crianças com rim displásico multicístico unilateral diagnosticado pela ultra-sonografia fetal entre 1989 e 2004. Todos os pacientes foram submetidos a protocolo sistemático, incluindo tratamento conservador e exames clínicos, laboratoriais e ultra-sonográficos periódicos. Os exames foram realizados com periodicidade de 6 meses, nos 2 primeiros anos, e anualmente, após esse período. No curso clínico, foram avaliados: pressão arterial, infecção do trato urinário, função renal e crescimento dos pacientes. Na evolução ecográfica, foram avaliados a involução do rim displásico multicístico e o crescimento do rim contralateral. RESULTADOS: O tempo médio de seguimento foi de 68 meses. Dois pacientes apresentaram hipertensão arterial no seguimento. Cinco tiveram infecção urinária (apenas um com episódios repetidos). Não houve degeneração maligna do rim displásico multicístico. Foram realizados 334 exames ultra-sonográficos seriados. Houve involução do rim displásico multicístico em 90% dos casos, sendo que nove (17%) desapareceram. O ritmo de involução foi maior nos 30 primeiros meses de vida. Houve progressiva hipertrofia compensatória do rim contralateral, sendo o ritmo mais intenso nos 2 primeiros anos de vida. CONCLUSÃO: Os resultados do acompanhamento prospectivo de crianças portadoras de rim displásico multicístico tratadas conservadoramente sugerem que a conduta clínica é segura, a incidência de complicações é mínima e há uma nítida tendência de involução ultra-sonográfica da unidade renal afetada. Os dados sugerem, ainda, que o ritmo de involução do rim displásico multicístico, assim como da hipertrofia compensatória do rim contralateral, sejam maiores nos 2 primeiros anos de vida.OBJECTIVE:The aim of this study was to describe the clinical course and ultrasound outcome of prenatally detected multicystic dysplastic kidney. METHODS: Fifty-three children with unilateral multicystic dysplastic kidney detected by prenatal ultrasound between 1989 and 2004 were included in the analysis. All children were submitted to conservative management with follow-up visits every six months. Follow-up ultrasound examinations were performed at six-month intervals during the first two years of life and yearly thereafter. The following clinical parameters were evaluated: blood pressure, urinary tract infection, renal function, and growth. The following ultrasound parameters were evaluated: involution of multicystic dysplastic kidney and contralateral renal growth. RESULTS: The mean follow-up time was 68 months. Two children presented hypertension during follow-up and five had urinary tract infection (only one with recurrent episodes). There was no malignant degeneration of multicystic dysplastic kidney. A total of 334 ultrasound scans were analyzed. US scan demonstrated involution of the multicystic dysplastic kidney in 48 (90%) cases, including complete involution in nine (17%). The involution rate was faster in the first 30 months of life. There was progressive compensatory renal hypertrophy of the contralateral renal unit; the rate of growth was greater in the first 24 months of life. CONCLUSION: The results of prolonged follow-up of children with conservatively managed multicystic dysplastic kidney suggest that clinical approach is safe, the incidence of complications is small, and that there is a clear tendency for multicystic dysplastic kidney to decrease in size. Our data also suggest that the involution rate of multicystic dysplastic kidney as well as the growth of the contralateral kidney is greater in the first 24 months of life.

Eli Armando S. Rabelo; Eduardo A. Oliveira; José Maria Penido Silva; Maria Cândida F. Bouzada; Bárbara C. Sousa; Mirela N. Almeida; Edson Samesima Tatsuo

2005-01-01

391

Bone stress injuries  

International Nuclear Information System (INIS)

Bone stress injuries are due to cyclical overuse of the bone. They are relatively common in athletes and military recruits but also among otherwise healthy people who have recently started new or intensive physical activity. Diagnosis of bone stress injuries is based on the patient's history of increased physical activity and on imaging findings. The general symptom of a bone stress injury is stress-related pain. Bone stress injuries are difficult to diagnose based only on a clinical examination because the clinical symptoms may vary depending on the phase of the pathophysiological spectrum in the bone stress injury. Imaging studies are needed to ensure an early and exact diagnosis, because if the diagnosis is not delayed most bone stress injuries heal well without complications

2004-01-01

392

Bone stress injuries  

Energy Technology Data Exchange (ETDEWEB)

Bone stress injuries are due to cyclical overuse of the bone. They are relatively common in athletes and military recruits but also among otherwise healthy people who have recently started new or intensive physical activity. Diagnosis of bone stress injuries is based on the patient's history of increased physical activity and on imaging findings. The general symptom of a bone stress injury is stress-related pain. Bone stress injuries are difficult to diagnose based only on a clinical examination because the clinical symptoms may vary depending on the phase of the pathophysiological spectrum in the bone stress injury. Imaging studies are needed to ensure an early and exact diagnosis, because if the diagnosis is not delayed most bone stress injuries heal well without complications.

Kiuru, M.J.; Pihlajamaeki, H.K.; Ahovuo, J.A. [Helsinki Univ. Central Hospital (Finland). Dept. of Radiology

2004-05-01

393

Accuracy evaluation of a new three-dimensional reproduction method of edentulous dental casts, and wax occlusion rims with jaw relation.  

UK PubMed Central (United Kingdom)

The article introduces a new method for three-dimensional reproduction of edentulous dental casts, and wax occlusion rims