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Sample records for sclerotic bone rim

  1. Fixation of hydroxyapatite-coated revision implants is improved by the surgical technique of cracking the sclerotic bone rim

    Elmengaard, Brian; Bechtold, Joan E; Chen, X; Søballe, Kjeld

    2009-01-01

    Revision joint replacement has poorer outcomes that have been associated with poorer mechanical fixation. We investigate a new bone-sparing surgical technique that locally cracks the sclerotic bone rim formed during aseptic loosening. We inserted 16 hydroxyapatite-coated implants bilaterally in the...... perform a systematic local perforation of the sclerotic bone rim of the revision cavity. After 4 weeks, the hydroxyapatite-coated implants were evaluated for mechanical fixation by a push-out test and for tissue distribution by histomorphometry. The cracking revision procedure resulted in significantly...... improved mechanical fixation, significantly more bone ongrowth and bone volume in the gap, and reduced fibrous tissue compared to the control revision procedure. The study demonstrates that the sclerotic bone rim prevents bone ingrowth and promotes fixation by fibrous tissue. The effect of the cracking...

  2. Cystinosis with sclerotic bone lesions.

    Sirrs, S; Munk, P; Mallinson, P I; Ouellette, H; Horvath, G; Cooper, S; Da Roza, G; Rosenbaum, D; O'Riley, M; Nussbaumer, G; Hoang, L N; Lee, C H

    2014-01-01

    A 26-year-old male with nephropathic cystinosis treated with cysteamine and renal transplantation presented for evaluation of multiple sclerotic bone lesions, which were an incidental finding on chest computerized tomography. These lesions were in a pattern consistent with osteoblastic metastases. He did not have a history of clinically significant hyperparathyroidism or cytopenias either preceding or following his transplant. Bone and tumor markers (including alkaline phosphatase and calcium) were all normal. A percutaneous bone biopsy of the lesions showed changes compatible with cystine deposition. Our case demonstrates that sclerotic bone lesions can be a feature of cystinosis in patients with normal parathyroid function and that significant bone marrow infiltration with cystine can be present even in the absence of cytopenias. PMID:24097416

  3. An Inflammatory Dentigerous Cyst Shows Rim Uptake on Bone Scan: A Case Report

    Son, Hye Joo; Jeong, Young Jin; Jeong, Jin Sook; Kang, Doyoung [Dong-A Univ. Medical Center, Busan (Korea, Republic of)

    2014-03-15

    Dentigerous cysts are developmental odontogenic jaw cysts, commonly manifesting in the 2nd and 3rd decades of life. This article presents an extremely rare case of dentigerous cyst showing increased uptake in the peripheral rim on bone scan. Herein, we discuss the clinical, radiographic, and histologic features of dentigerous cysts as well as the pathological mechanism underlying their activities on the bone scan. Bone scan was a sensitive tool for detecting the biologic activity of dentigerous cyst in our case.

  4. Bone changes in tuberous sclerosis mimicking metastases

    Pui, M.H.; Kong Hwai Loong; Choo Hui Fen [National University Hospital (Singapore). Depts. of Diagnostic Radiology and Oncology

    1996-02-01

    Sclerotic and lytic bone changes of tuberous sclerosis (TS) can mimic bone metastases. A case is reported of a patient with concomitant sclerotic bone metastases from bronchogenic carcinoma and TS bone changes, diagnosed by bone scintigraphy and magnetic resonance imaging. The increased bone uptake and abnormal magnetic resonance signal allowed distinction of TS bone lesions from bone metastases. 6 refs., 4 figs.

  5. Bone changes in tuberous sclerosis mimicking metastases

    Sclerotic and lytic bone changes of tuberous sclerosis (TS) can mimic bone metastases. A case is reported of a patient with concomitant sclerotic bone metastases from bronchogenic carcinoma and TS bone changes, diagnosed by bone scintigraphy and magnetic resonance imaging. The increased bone uptake and abnormal magnetic resonance signal allowed distinction of TS bone lesions from bone metastases. 6 refs., 4 figs

  6. The sclerotic pedicle - how many causes are there?

    The sclerotic pedicle is a commonly encountered roentgen sign that may be associated with numerous conditions, both benign and malignant. The following paper discusses the common as well as the unusual causes of this interesting phenomenon and demonstrates the radiographic presentations of the various etiologies. (orig.)

  7. Development of Natural Culture Media for Rapid Induction of Fonsecaea pedrosoi Sclerotic Cells In Vitro▿

    da Silva, Moises Batista; da Silva, Jorge Pereira; Sirleide Pereira Yamano, Suellen; Salgado, Ubirajara Imbiriba; Diniz, José Antonio Picanço; Salgado, Claudio Guedes

    2008-01-01

    Fonsecaea pedrosoi is the main agent of chromoblastomycosis, a skin disease presenting verrucous lesions, in which round, thick-walled sclerotic cells are found. In vitro induction of sclerotic cells is time-consuming (20 to 45 days) and temperature dependent. We present two new natural media that reduce the sclerotic-cell induction time to only 2 days.

  8. Indian Ocean Rim Cooperation

    Wippel, Steffen

    Since the mid-1990s, the Indian Ocean has been experiencing increasing economic cooperation among its rim states. Middle Eastern countries, too, participate in the work of the Indian Ocean Rim Association, which received new impetus in the course of the current decade. Notably Oman is a very active...

  9. Alar Rim Deformities.

    Totonchi, Ali; Guyuron, Bahman

    2016-01-01

    The alar rim plays an important role in nasal harmony. Alar rim flaws are common following the initial rhinoplasty. Classification of the deformities helps with diagnosis and successful surgical correction. Diagnosis of the deformity requires careful observation of the computerized or life-sized photographs. Techniques for treatment of these deformities can easily be learned with attention to detail. PMID:26616701

  10. Dopamine-Mediated Sclerotization of Regenerated Chitin in Ionic Liquid

    Dongyeop X. Oh

    2013-09-01

    Full Text Available Chitin is a promising structural material for biomedical applications, due to its many advantageous properties and abundance in nature. However, its usage and development in the biomedical field have been stagnant, because of chitin’s poor mechanical properties in wet conditions and the difficulties in transforming it into an applicable form. To overcome these challenges, we created a novel biomimetic chitin composite. This regenerated chitin, prepared with ionic liquid, showed improved mechanical properties in wet conditions by mimicking insect cuticle and squid beak sclerotization, i.e., catechol-meditated cross-linking. By ionic liquid-based heat treatment, dopamine oxidation produced melanin-like compounds and dopamine-meditated cross-links without any solvent evaporation and oxidant utilization. The dopamine-meditated sclerotization increased the ultimate tensile strength (UTS of the regenerated chitin by 2.52-fold, measured after six weeks of phosphate-buffered saline (PBS submersion. In addition, the linear swelling ratio (LSR of the chitin film was reduced by about 22%. This strategy raises a possibility of using regenerated chitin as an artificial hard tissue in wet conditions.

  11. Rim inertial measuring system

    Groom, N. J.; Anderson, W. W.; Phillips, W. H. (Inventor)

    1981-01-01

    The invention includes an angular momentum control device (AMCD) having a rim and several magnetic bearing stations. The AMCD is in a strapped down position on a spacecraft. Each magnetic bearing station comprises means, including an axial position sensor, for controlling the position of the rim in the axial direction; and means, including a radial position sensor, for controlling the position of the rim in the radial direction. A first computer receives the signals from all the axial position sensors and computes the angular rates about first and second mutually perpendicular axes in the plane of the rim and computes the linear acceleration along a third axis perpendicular to the first and second axes. A second computer receives the signals from all the radial position sensors and computes the linear accelerations along the first and second axes.

  12. Multifocal sclerotic BCG spondylitis in a 13-year-old girl

    A case is reported of multifocal BCG osteomyelitis in a 13-year-old girl. The lesions in the skull, ribs and in several vertebrae were mainly sclerotic and healed with antituberculotic therapy. The case is unusual because of the late onset, sclerotic changes, and involvement of the spine. (orig.)

  13. Degraded Crater Rim

    2002-01-01

    (Released 3 May 2002) The Science The eastern rim of this unnamed crater in Southern Arabia Terra is very degraded (beaten up). This indicates that this crater is very ancient and has been subjected to erosion and subsequent bombardment from other impactors such as asteroids and comets. One of these later (younger) craters is seen in the upper right of this image superimposed upon the older crater rim material. Note that this smaller younger crater rim is sharper and more intact than the older crater rim. This region is also mantled with a blanket of dust. This dust mantle causes the underlying topography to take on a more subdued appearance. The Story When you think of Arabia, you probably think of hot deserts and a lot of profitable oil reserves. On Mars, however, Southern Arabia Terra is a cold place of cratered terrain. This almost frothy-looking image is the badly battered edge of an ancient crater, which has suffered both erosion and bombardment from asteroids, comets, or other impacting bodies over the long course of its existence. A blanket of dust has also settled over the region, which gives the otherwise rugged landscape a soft and more subdued appearance. The small, round crater (upper left) seems almost gemlike in its setting against the larger crater ring. But this companionship is no easy romance. Whatever formed the small crater clearly whammed into the larger crater rim at some point, obliterating part of its edge. You can tell the small crater was formed after the first and more devastating impact, because it is laid over the other larger crater. How much younger is the small one? Well, its rim is also much sharper and more intact, which gives a sense that it is probably far more youthful than the very degraded, ancient crater.

  14. Transplante renal sem imunossupressão de manutenção. Pares monozigóticos e receptores de rim e medula óssea do mesmo doador / Renal transplantation without maintenance immunosuppression. Identical twins and kidney transplantation following a successful bone marrow graft

    Riad Abdel, Hadi; Gustavo Gomes, Thomé; Adriana Reginato, Ribeiro; Roberto Ceratti, Manfro.

    2015-06-01

    Full Text Available Resumo Pacientes que receberam transplantes renais sem imunossupressão de manutenção têm sido esporadicamente relatados. Os casos incluem relatos de pacientes não aderentes que suspenderam a medicação imunossupressora, transplantes entre gêmeos monozigóticos, transplante renal após um bem sucedido t [...] ransplante de medula óssea do mesmo doador e transplante simultâneo de medula óssea e rim para tratamento de pacientes com mieloma múltiplo com insuficiência renal associada. Existem, atualmente, ensaios clínicos em andamento com o propósito de induzir tolerância imunológica específica ao doador utilizando a infusão de células hematopoiéticas do mesmo doador do enxerto renal. A seguir, descrevemos dois casos de transplante renal sem imunossupressão como exemplos de situações descritas acima. Abstract in english Abstract Renal transplantation without maintenance immunosuppression has been sporadically reported in the literature. The cases include non-adherent patients who discontinued their immunosuppressive medications, transplantation between identical twins, kidney transplantation after a successful bone [...] marrow graft from the same donor and simultaneous bone marrow and kidney transplantation for the treatment of multiple myeloma with associated renal failure. There are also ongoing clinical trials designed to induce donor specific transplant tolerance with infusion of hematopoietic cells from the same kidney donor. Here we describe two cases of renal transplantation without immunosuppression as examples of situations described above.

  15. Micromorphological and hardness analyses of human and bovine sclerotic dentin: a comparative study

    Gisela Muassab Castanho

    2011-06-01

    Full Text Available The purpose of this study was to test the hypothesis that both human and bovine sclerotic dentin have similar hardness properties, in addition to similar micromorphological characteristics. Sixteen teeth (8 human and 8 bovine exhibiting exposed dentin in the incisal edge and showing characteristics typical of sclerosis were used. Vickers surface microhardness testing was conducted. Three areas of the dentin surface of each specimen were selected. All teeth were processed for scanning electron microscopy in order to estimate the amount (in percentage of solid dentin on the sclerotic dentin surface. The data were compared by Student's t test (? = 0.05. The micromorphological and microhardness data were compared by Pearson's linear correlation test (? = 0.05. The mean percentages of solid dentin of human and bovine sclerotic dentin were similar (human 90.71 ± 0.83 and bovine 89.08 ± 0.81, p = 0.18. The mean microhardness value (VHN of human sclerotic dentin was significantly higher than that of bovine sclerotic dentin (human 45.26 ± 2.92 and bovine 29.93 ± 3.83, p = 0.006. No correlation was found between the microhardness values and the amount of solid dentin in the sclerotic dentin, irrespective of the species considered (human R² = 0.0240, p = 0.714; bovine R² = 0.0017, p = 0.923; and combined R² = 0.038, p = 0.46. We concluded that although both bovine and human sclerotic dentin present a similar amount of solid tissue, human sclerotic dentin presents higher microhardness than bovine sclerotic dentin.

  16. Optimization Of Car Rim

    Mr. Sushant K. Bawne

    2015-10-01

    Full Text Available The essential of car wheel rim is to provide a firm base on which to fit the tyre. Its dimensions, shape should be suitable to adequately accommodate the particular tyre required for the vehicle. In this project a tyre of car wheel rim belonging to the disc wheel category is considered. Design is an important industrial activity which influences the quality of the product. The wheel rim is modeled by using modeling software catiav5r17. By using this software the time spent in producing the complex 3- D models and the risk involved in the design and manufacturing process can be easily minimized. So the modeling of the wheel rim is made by using CATIA. Later this CATIA modal is imported to ANSYS WORKBENCH 14.5 for analysis work. ANSYS WORKBENCH 14.5 is the latest software used for simulating the different forces, pressure acting on the component and also calculating and viewing the results. By using ANSYS WORKBENCH 14.5 software reduces the time compared with the method of mathematical calculations by a human. ANSYS WORKBENCH 14.5 static structural analysis work is carried out by considered three different materials namely aluminum alloy ,magnesium alloy and structural steel and their relative performances have been observed respectively. In addition to wheel rim is subjected to modal analysis, a part of dynamic analysis is carried out its performance is observed. In this analysis by observing the results of both static and dynamic analysis obtained magnesium alloy is suggested as best material.

  17. RIMS: Resource Information Management System

    Symes, J.

    1983-01-01

    An overview is given of the capabilities and functions of the resource management system (RIMS). It is a simple interactive DMS tool which allows users to build, modify, and maintain data management applications. The RIMS minimizes programmer support required to develop/maintain small data base applications. The RIMS also assists in bringing the United Information Services (UIS) budget system work inhouse. Information is also given on the relationship between the RIMS and the user community.

  18. Sclerotic fibroma-like dermatofibroma: an uncommon distinctive variant of dermatofibroma

    González-Vela, M.C.; Val-Bernal, José Fernando; de Martino, M; González-López, M.A.; García-Alberdi, E.; Hermana, S.

    2005-01-01

    Dermatofibroma (DF) is a common benign cutaneous tumor with many variants based on alterations in the morphology and composition of its diverse elements. One very infrequent type is sclerotic fibromalike DF (SF-DF). We report 7 new cases of SF-DF. In addition, their main clinicopathological and immunohistochemical features were compared with 14 unselected common DFs and with 3 sclerotic fibromas (SFs). Microscopically, the 7 cases of SF-DFs showed an un...

  19. Microscopy comparative evaluation of the SE systems adhesion to normal and sclerotic dentin.

    Florescu, Anamaria; Efrem, Ion Cristian; Haidoiu, Cerasela; Hertzog, Radu; Bîcle?anu, Florentina Cornelia

    2015-01-01

    The purpose of this study was in vitro evaluation and comparison of the adhesion of self-etch (SE) adhesive systems applied on normal and sclerotic dentin. For this study, Class 5 cavities were prepared on sound teeth as well as on teeth with sclerotic dentin. They were then restored by means of the SE 2-step OptiBond XTR (Kerr) and SE 1-step Bond Force (Tokuyama Dental) adhesive systems, as well as the Estelite Sigma Quick (Tokuyama Dental) composite resin. For teeth with sclerotic dentin, the hypermineralized superficial layer was removed by means of round bur on low speed, than the adhesive systems and composite resin were applied. These teeth were prepared for microscopic study according to the protocol specific to each microscope. SEM (scanning electron microscopy) examination reveals that on normal and sclerotic dentin, OptiBond XTR and Bond Force form hybrid layers with about the same thickness, greater in normal dentin, but only OptiBond XTR pervades into the dentinal tubules, both in normal and sclerotic dentin. However, TEM (transmission electron microscopy) examination of Bond Force reveals that it penetrates into the dentinal tubules as well, but only in the case of normal dentin. The thickness of the hybrid layers resulting from the application of the SE adhesive systems to sound dentin is different from the thickness of the hybrid layers obtained when the same adhesive systems have been applied to sclerotic dentin. PMID:26662138

  20. AVALIAÇÃO HISTOLÓGICA DE FÍGADO, RIM, TIREÓIDE, PARATIREÓIDE E OSSO DE SUÍNOS EM TERMINAÇÃO SUBMETIDOS A DIFERENTES DIETAS HISTOLOGICS AVALUATIONS OF LIVER, KIDNEY, THYROID, PARATHYROID AND METACARPIAN BONE OF FINISHING PIGS WITH DIFFERENT DIETS

    Jurij Sobestiansky

    2008-12-01

    Full Text Available O objetivo do estudo foi avaliar histologicamente fígado, rim, tireóide, paratireóide e osso metacarpo de suínos submetidos a restrições de microminerais, vitaminas e fósforo, e suplementados com a enzima fitase em dois períodos de restrição. Empregaram-se 48 fêmeas suínas com idade inicial de 105 dias (66,15 ± 0,14kg, recebendo dietas experimentais à base de milho e farelos de soja e trigo. Os animais foram agrupados aleatoriamente em seis tratamentos: dieta completa (T1; dieta completa sem suplemento micromineral-vitamínico (T2; dieta sem suplemento micromineral-vitamínico e com fitase (T3; dieta sem suplemento micromineral-vitamínico, sem 1/3 de fósforo inorgânico e com fitase (T4; dieta sem suplemento micromineral-vitamínico, sem 2/3 de fósforo inorgânico e com fitase (T5; dieta sem suplemento micromineral-vitamínico, sem fósforo inorgânico e com fitase (T6. Desenvolveu-se o experimento em duas etapas, sendo a primeira composta por 24 animais, restrição de 35 dias e abate aos 150 dias (106,65 kg, e a segunda, composta por 24 animais, restrição de 60 dias e abate aos 175 dias (123,87 kg. No momento do abate, colheram-se fragmentos de fígado, rim, tireóide, paratireóide e osso metacarpiano de cada animal dos diversos tratamentos. Todos os fragmentos foram fixados em solução de formol tamponado a 10%, processados, incluídos em parafina e corados por hematoxilina e eosina (HE. Empregou-se a coloração especial de tricrômico de Mallory apenas nas amostras ósseas. Ao exame histológico dos rins foram constatados 37 animais com nefrite intersticial (77%. À histologia hepática, observou-se discreto infiltrado inflamatório mononuclear de distribuição predominantemente focal em quinze animais (31,25%. Os tratamentos preconizados não provocaram alterações histológicas nas glândulas paratireóide e tireóide. À microscopia dos ossos metacarpianos, observou-se discreta osteocondrose em animais dos diferentes tratamentos e fases de restrição. Entretanto, durante o período experimental não se registraram quaisquer alterações clínicas relacionadas a doenças metabólicas ósseas ou a osteocondrose. Ainda, de acordo com os resultados, concluiu-se que a fitase foi eficiente em disponibilizar o fósforo fítico da dieta, uma vez que não se observaram lesões ósseas macro e microscópicas características de deficiência de fósforo.

    PALAVRAS-CHAVES: Alterações histológicas, fitase, restrição de fósforo, vitaminas, microminerais. The present experiment aimed to evaluate histological changes in hepatic, renal, thyroid, parathyroid and metacarpian bone tissues of pigs submitted to diets without micro minerals and vitamins, reduced inorganic phosphorus levels and phytase addition in two restriction times. Forty eight 105-days old (66.15±0.14 kg female pigs received experimental diets with corn, soybean and wheat meal. The animals were randomly distributed in six groups: standard diets (T1; composed of corn, soybean meal and wheat meal; standard ration without micro mineral and vitamin supplement (T2; T2 ration with phytase (T3; T2 ration reducing 1/3 of inorganic phosphorus with phytase (T4; T2 ration reduced 2/3 of inorganic phosphorus with phytase (T5; and T2 ration with complete reduction of inorganic phosphorus with phytase (T6. The experiment was carried out in two phases: Phase 1. 24 animals, 35 days of restriction and slaughter at 150 days of age (106.65 kg, and Phase 2, 24 animals, 60 days of restriction and slaughter at 175 days of age (123.87 kg. At slaughter, samples of liver, kidney, thyroid, parathyroid and metacarpian bone were collected from all animals. The samples were fixed in 10% buffered formaldehyde and stained by hematoxilin and eosin (HE. The Mallory’s trichrome stain was used in bone sections. Kidney histopathological evaluation showed interstitial nephritis in 37 animals (77%. Mononuclear inflammatory infiltrated was observed focally on liver of 15 animals (31.25%. Treatments didn’t promote histopathologi

  1. CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS

    Taeko Nakamura-Wakatsuki

    2013-10-01

    Full Text Available Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fingers have not been reported to date. Mucin deposition in the sclerotic skin may be a predisposing factor in the induction of myxoid cyst on the scleroderma finger in our patient.

  2. Aft outer rim seal arrangement

    Lee, Ching-Pang; Tham, Kok-Mun; Schroeder, Eric; Meeroff, Jamie; Miller, Jr., Samuel R; Marra, John J; Campbell, Christian X

    2015-04-28

    An outer rim seal arrangement (10), including: an annular rim (70) centered about a longitudinal axis (30) of a rotor disc (31), extending fore and having a fore-end (72), an outward-facing surface (74), and an inward-facing surface (76); a lower angel wing (62) extending aft from a base of a turbine blade (22) and having an aft end (64) disposed radially inward of the rim inward-facing surface to define a lower angel wing seal gap (80); an upper angel wing (66) extending aft from the turbine blade base and having an aft end (68) disposed radially outward of the rim outward-facing surface to define a upper angel wing seal gap (80, 82); and guide vanes (100) disposed on the rim inward-facing surface in the lower angel wing seal gap. Pumping fins (102) may be disposed on the upper angel wing seal aft end in the upper angel wing seal gap.

  3. Morphology of autogenous bone graft and castor oil polyurethane in the infraorbital rim of rabbits: a comparative study Estudo morfológico comparativo do enxerto ósseo autógeno e polímero de mamona em rebordo infra-orbitário de coelhos

    José Carlos Garcia de Mendonça; Rafael Rossi; Celso Massaschi Inouye; Diego Rodrigo Paulillo Bazan; João Carlos Castro Monteiro; Juliana Pedroso de Mendonça

    2006-01-01

    PURPOSE: Morphological study comparing castor oil polyurethane and autogenous bone graft to repair bone defect in zygomatic bone of rabbits. METHODS: Twenty-four adult, male New Zealand rabbits were randomly distributed between two groups of twelve. Bone defects of 5mm in diameter were cut through the zygomatic bone and filled with polyurethane discs in the experimental group or autogenous bone harvested from the tibia in the control group. Animals were sacrificed after 30, 60 or 90 days, and...

  4. ISOLATED TUBERCULOSIS OF NAVICULAR BONE: A CASE REPORT

    Indudhara; Harish; Yenni

    2015-01-01

    Skeletal tuberculosis rare in foot. Bones generally involved are the spine ( D orso - lumbar), skull, shoulder girdle and hip bones. Involvement of the foot is infrequent. Very rare in navicular bone. A female of 23 years presented with swelling and pain in of right foot. X - ray showed lytic lesion with sclerotic margins. Biop...

  5. Portable basketball rim testing device

    Abbott, W. Bruce (610 Clover St., Cheney, WA 99004); Davis, Karl C. (Box 722, Richland, WA 99352)

    1993-01-01

    A portable basketball rim rebound testing device 10 is illustrated in two preferred embodiments for testing the rebound or energy absorption characteristics of a basketball rim 12 and its accompanying support to determine likely rebound or energy absorption charcteristics of the system. The apparatus 10 includes a depending frame 28 having a C-clamp 36 for releasably rigidly connecting the frame to the basketball rim 12. A glide weight 60 is mounted on a guide rod 52 permitting the weight 60 to be dropped against a calibrated spring 56 held on an abutment surface on the rod to generate for deflecting the basketball rim and then rebounding the weight upwardly. A photosensor 66 is mounted on the depending frame 28 to sense passage of reflective surfaces 75 on the weight to thereby obtain sufficient data to enable a processing means 26 to calculate the rebound velocity and relate it to an energy absorption percentage rate of the rim system 12. A readout is provided to display the energy absorption percentage.

  6. Sclerotic fibroma (storiform collagenoma)-like stroma in a fibroadenoma of axillary accessory breast tissue.

    Val-Bernal, José Fernando; González-Vela, María Carmen; De Grado, Mauricio; Garijo, María Francisca

    2012-08-01

    Accessory breast tissue is a subcutaneous remnant persisting after normal embryological development of the breast. It occurs most frequently in the axilla. Fibroadenomas in axillary breast tissue are rare. We report the case of a 29-year-old female patient who presented a fibroadenoma arising in the accessory breast tissue of the right axillary fossa. The neoplasm showed foci of sclerotic fibroma-like stroma. The patient had no signs of Cowden's syndrome. To the best of our knowledge, a lesion of this kind has not been previously reported. This stromal change suggests an uncommon involutional phase of the fibroadenoma with production of sclerotic and hypocellular collagen. The lesion should be differentiated from extraneural perineuroma, from the changes in fibroadenomas in Cowden's syndrome, from sclerosing lobular hyperplasia (fibroadenomatoid mastopathy) and from pseudoangiomatous stromal hyperplasia. PMID:22804110

  7. Ewing's sarcoma of the tarsal bone

    The Ewing's sarcoma comprises approximately less than 10 percent of malignant bone tumors and 5 percent of all bone tumors, occurs in almost all bones of the body, and presents a widely divergent roentgenographic manifestations. The tarsal bones are involved only 2 percent in the Ewing's sarcoma. Two cases experienced by authors and ten cases published in literatures of Ewing's sarcoma of the tarsal bone were analyzed retrospectively. The result were as follows: 1. Of the tarsal bones, the calcaneus was 7 cases, the talus 4 cases, cuneiform 1 case. 2. Female was affected more commonly than male, the ratio being 4 to 1 in the tarsal bones. 3. About sixty percent of total cases in the tarsal bones had evidence of diffuse sclerotic pattern. All the cases of the talus had evidence of diffuse sclerotic pattern. 4. The diseases to be considered in differential diagnosis are as follows: avascular necrosis, tuberculous osteomyelitis, osteosarcoma, and pyogenic osteomyelitis. 5. The diffuse sclerosis radiographically showed a close relation with dead bone resulting from avascular necrosis due to tumor infiltration histologically. Periosteal reactive new bone and osteoid deposition on the dead bone were also correlated with diffuse sclerosis. 6. Because it is difficult to differentiate sclerotic lesions in the tarsal bones by radiographic methods alone, all such lesions should be subject to biopsy as early as possible

  8. In vitro evaluation of the microhardness of normal and sclerotic bovine dentin

    Gisela Muassab CASTANHO

    2009-06-01

    Full Text Available Introduction:The literature shows different characteristics between normal and sclerotic dentin.Hardness is a property that has been very used to compare restorative materials and biological tissues.Objective: The aim of this study was to compare the hardness clinical characteristics between the normal and the sclerotic bovine dentin, through the microhardness test.Material and methods: 20 bovine teeth were divided in two groups: GI (normal and GII (with characteristics of sclerosis.The teeth were mounted in acrylic resin cylinders with exposure of dentin along the incisal edges. The specimens received finishing and polishing following by storage in distilled water at ambient temperature for 7 days.Microhardness measurements were made using a Vickers indenter microhardness tester under a load of 50 gf for 45 s.In this study 3 areas per specimen were selected and each specimen were selected and each area received 5 indentations, resulting in 15 indentations per specimen. Results: The data were statistically processed using the Student’s t-test.The level of significance was 5%. The results showed no significant differences between the mean values of the two groups (GI: 36.82±9.45; GII:32.4±12.2 (p = 0.383.Conclusion:The normal bovine dentin presented similar microhardness Vickers values to the sclerotic bovine dentin.

  9. Analysis of the Rim Inertial Measuring System (RIMS)

    Joshi, S. M.

    1980-01-01

    Nonlinear equations of motion are derived for the rim inertial measuring system, which is mounted in a strapped down configuration on a carrier vehicle. The measurement and equations derived from angular rates and linear accelerations were interfaced with the dynamic model of a user defined carried vehicle. Two methods are presented for rate measurement, and the results of the nonlinear computer simulation are presented.

  10. Effects of Altered Catecholamine Metabolism on Pigmentation and Physical Properties of Sclerotized Regions in the Silkworm Melanism Mutant

    Qiao, Liang; Li, Yuanhao; Xiong, Gao; Liu, Xiaofan; He, Songzhen; Tong, Xiaoling; Wu, Songyuan; Hu, Hai; Wang, Rixin; Hu, Hongwei; Chen, Lushi; De Zhang, Li; Wu, Jie; Dai, Fangyin; LU, Cheng

    2012-01-01

    Catecholamine metabolism plays an important role in the determination of insect body color and cuticle sclerotization. To date, limited research has focused on these processes in silkworm. In the current study, we analyzed the interactions between catecholamines and melanin genes and their effects on the pigmentation patterns and physical properties of sclerotized regions in silkworm, using the melanic mutant melanism (mln) silkworm strain as a model. Injection of β-alanine into mln mutant si...

  11. Trade in the Pacific Rim.

    Dollar, David

    1988-01-01

    States that international trade is a prime factor linking the Pacific Rim nations. Discusses the differences in each nation's productive factors (land, labor, capital) and examines the emerging technological competition. Concludes that if U.S. firms cannot meet the challenge of foreign competition, then protectionism might limit further economic…

  12. A digital image analyser for RIMS studies

    Resonance Ionisation Mass Spectrometry (RIMS) is now playing a vital role in various areas of physics and chemistry. A digital image analyser for quantitative analysis of RIMS experiments has been developed

  13. The Sclerotic Scatter Limbal Arc Is More Easily Elicited under Mesopic Rather Than Photopic Conditions

    Denion, Eric; Lux, Anne-Laure; Mouriaux, Frédéric; Béraud, Guillaume

    2016-01-01

    Introduction We aimed to determine the limbal lighting illuminance thresholds (LLITs) required to trigger perception of sclerotic scatter at the opposite non-illuminated limbus (i.e. perception of a light limbal scleral arc) under different levels of ambient lighting illuminance (ALI). Material and Methods Twenty healthy volunteers were enrolled. The iris shade (light or dark) was graded by retrieving the median value of the pixels of a pre-determined zone of a gray-level iris photograph. Mean keratometry and central corneal pachymetry were recorded. Each subject was asked to lie down, and the ALI at eye level was set to mesopic values (10, 20, 40 lux), then photopic values (60, 80, 100, 150, 200 lux). For each ALI level, a light beam of gradually increasing illuminance was applied to the right temporal limbus until the LLIT was reached, i.e. the level required to produce the faint light arc that is characteristic of sclerotic scatter at the nasal limbus. Results After log-log transformation, a linear relationship between the logarithm of ALI and the logarithm of the LLIT was found (p<0.001), a 10% increase in ALI being associated with an average increase in the LLIT of 28.9%. Higher keratometry values were associated with higher LLIT values (p = 0.008) under low ALI levels, but the coefficient of the interaction was very small, representing a very limited effect. Iris shade and central corneal thickness values were not significantly associated with the LLIT. We also developed a censored linear model for ALI values ≤ 40 lux, showing a linear relationship between ALI and the LLIT, in which the LLIT value was 34.4 times greater than the ALI value. Conclusion Sclerotic scatter is more easily elicited under mesopic conditions than under photopic conditions and requires the LLIT value to be much higher than the ALI value, i.e. it requires extreme contrast. PMID:26964096

  14. Mixed Buchsbaum-Rim multiplicities

    Kleiman, S L; Kleiman, Steven; Thorup, Anders

    1994-01-01

    We prove the results about mixed Buchsbaum--Rim multiplicities announced in (9.10)(ii) on p.224 of our recent paper [J.Alg.(1994)], including a general mixed multiplicity formula. In addition, we identify these multiplicities as the coefficients of the ``leading form'' of the appropriate Buchsbaum-Rim polynomial in three variables, and we prove a positivity theorem. In fact, we define the multiplicities as the degrees of certain zero-dimensional ``mixed twisted Segre'' classes, and we develop an encompassing general theory of these new rational equivalence classes in all dimensions. In parallel, we develop a theory of pure ``twisted Segre'' classes, and we recover the main results in [J.Alg.(1994)] about the pure Buchsbaum--Rim multiplicities, the polar multiplicities, and so forth. Moreover, we identify the additivity theorem [J.Alg.(1994), (6.7b)(i), p.205] as a sort of residual-intersection formula, and we show its (somewhat unexpected) connection to the mixed multiplicity formula. Also, we work in a more ...

  15. Posterior segment nucleotomy for dislocated sclerotic cataractous lens using chandelier endoilluminator and sharp tipped chopper

    Brijesh Takkar

    2015-08-01

    Full Text Available AIM:To describe a new surgical technique for managing dislocated sclerotic cataractous lens.METHODS:Six patients with advanced posteriorly dislocated cataracts were operated at a tertiary care centre and analyzed retrospectively. After standard 3 port 23 G pars plana vitrectomy and perfluorocarbon liquid (PFCL injection, the dislocated white cataract was held with occlusion using phaco fragmatome and then chopped into smaller pieces with a sharp tipped chopper using 25 G chandelier endoilluminator. Each piece was emulsified individually. Following aspiration of PFCL, Fluid Air Exchange was done in all the cases and surgery completed uneventfully.RESULTS:Best corrected visual acuity (BCVA in all the patients was better than 6/12 after one month of follow up. No serious complications were noted till minimum 6mo of follow up.CONCLUSION:Four port posterior segment nucleotomy with a chandelier endoilluminator, fragmatome and a chopper appears to be a safe, easy and effective procedure for managing dislocated sclerotic cataractous nuclei. Ultrasonic energy used and adverse thermal effects of the fragmatome on the sclera may be lesser.

  16. Imaging features of hemangioma in the long bone

    Objective: To explore the imaging features of hemangioma in the long bone and improve the diagnostic level of this disease. Methods: The X-ray (14 cases), CT (9 cases) and MRI (6 cases) findings of 18 patients with histologically proven hemangioma in the long bone after surgery were retrospectively reviewed. Results: Ten tumors occurred in medullary cavity or bone end (medullary type), 6 on the surface of bone (periosteal type) and 3 in cortex (intracortical type). X-ray findings: among 8 cases of medullary type, 3 showed honeycomb appearance, 3 lytic areas with sclerotic borders, one purely osteolytic changes, and 1 frosted glass; 3 cases of periosteal type showed sclerosis and thickening of the underlying cortex; 3 cases of intracortical type showed well defined osteolytic foci. CT findings: among 6 cases of medullary type, 5 appeared as expansile lytic lesion with uneven selerotic rim (3 cases) orhoneycomb appearance (2 cases), 1 cribriform appearance in the cortical bone, 2 periostealnew bone formation in vertical radiation pattern; 1 ground-glass appearance; among 2 cases of periosteal type-one showed regular cortical thickening, and the other irregular periosteal proliferation with marrowing of medullarycavity; 1 case of intracortical type showed density similar to that of soft tissue, with cortical thickening and expansion. MRI findings: 2 appeared as well-defined lesions with low signal intensity on T1WI and high signal intensity on T2WI; 1 appeared as ill-defined lesion with low to intermediate signal intensity on T1WI and T2WI. One showed breakthrough of cortex and formation of soft, tissue mass with low signal intensity on T1WI and high signal on T2WI. Two showed thickening of periosteum with intermediate signal intensity in one of them and very low signal intensity in the other. Two showed abnormal signal intensity in surrounding muscles, which was high on T2WI and intermediate on T1WI. Conclusions: The soap-bubble or honeycomb appearance is the typical radiographic finding of hemangioma in long bone. CT and MRI can provide useful information for the diagnosis of hemangioma in long bone. (authors)

  17. CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts: preliminary results

    Objective: To evaluate CT-guided once-through bilateral percutaneous needle puncturing, aspiration and injection of sclerotic agents (ethanol) in treating bilateral multiple renal cysts. Methods: CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy was performed in 19 patients with bilateral multiple renal cysts. First, under CT guidance the puncture points and puncture routs were decided, then, puncturing, aspiration, rinsing and ethanol injection of the cysts were taken place by turn. The clinical results were analyzed. Results: bilateral percutaneous needle puncturing sclerotic therapy was successfully completed in all 19 cases. The whole procedure was well tolerated by all patients. The mean operative time was 23 minutes with a range of 20-35 minutes. No severe complications occurred. Conclusion: With proficient manipulation, CT-guided bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts can be smoothly carried out. The technique can reduced the number of sclerotherapy times, cut down the medical expenses and, therefore, get twofold results with half the effort. (authors)

  18. ISOLATED TUBERCULOSIS OF NAVICULAR BONE: A CASE REPORT

    Indudhara

    2015-05-01

    Full Text Available Skeletal tuberculosis rare in foot. Bones generally involved are the spine ( D orso - lumbar, skull, shoulder girdle and hip bones. Involvement of the foot is infrequent. Very rare in navicular bone. A female of 23 years presented with swelling and pain in of right foot. X - ray showed lytic lesion with sclerotic margins. Biopsy was done and histopathological diagnosis of tuberculosis was made.

  19. Thermoviscous Coating and Rimming Flow

    Leslie, G. A.

    2012-10-22

    A comprehensive description is obtained of steady thermoviscous (that is, with temperature-dependent viscosity) coating and rimming flow of a thin film of fluid on a uniformly rotating horizontal cylinder that is uniformly hotter or colder than the surrounding atmosphere. It is found that, as in the corresponding isothermal problem, there is a critical solution with a corresponding critical load (which depends, in general, on both the Biot number B and the thermoviscosity number V) above which no \\'full-film\\' solutions corresponding to a continuous film of fluid covering the entire outside or inside of the cylinder exist. The effect of thermoviscosity on both the critical solution and the full-film solution with a prescribed load is described. In particular, there are no full-film solutions with a prescribed load M for any value of B when for positive V and when M ≥ f-1/2 Mc0 for negative V, where is a monotonically decreasing function of V and M c0 ≃ 4.44272 is the critical load in the constant-viscosity case. It is also found that, for the exponential viscosity model, when the prescribed load satisfies M < 1.50315 there is a narrow region of the B-V parameter plane in which backflow occurs. © 2012 The Author. Published by Oxford University Press; all rights reserved. For Permissions, please email: journals.permissions@oup.com.

  20. Desmoplastic Fibroma, Report of a Rare Case in Infraorbital Rim

    Safi, Yaser; Shamloo, Nafise; Heidar, Hossein; Valizadeh, Solmaz; Aghdasi, Mohammad Mehdi; Eslami Manouchehri, Maryam

    2015-01-01

    Desmoplastic fibroma (DF) is a rare and locally aggressive intraosseous tumor with unknown etiology. The mandible is the common site of involvement in the maxillofacial region. However, it is believed that DF can arise in any bone of the body. A wide age distribution has been reported for DF occurrence, extending from birth to the sixth decade of life, with a peak incidence at 10 to 19 years of age. In this study, diagnostic and therapeutic management of a 6-year-old girl with a desmoplastic fibroma of the inferior orbital rim and zygomatic buttress are discussed. Cone beam computed tomography (CBCT) revealed a mixed lesion in infraorbital rim, which had ill-defined borders and a straight thick bony septum inside the lesion. It also involved the zygomatic process of maxilla and zygomatic bone. According to radiologic concepts, this rare lesion may mimic fibro-osseous, benign and especially malignant lesions. Regarding different treatment plans, identification of this lesion is essential. Furthermore, presence of coarse and irregular or straight septa along with some imaging criteria for malignant lesions such as destruction of the cortex, periosteal reaction and soft tissue invasion would be helpful to differentiate this lesion from malignant and multilocular benign lesions. PMID:26557283

  1. Beyond the peak of the anterior glenoid rim: A cadaveric study

    Guillaume D Dumont

    2013-01-01

    Full Text Available Purpose: The purpose of this study was to quantify the width of bone beyond the peak of the anterior glenoid rim and to determine if this anatomic region of the glenoid significantly affects measurement of the anteroposterior glenoid diameter. Materials and Methods: 19 cadaveric scapulae were examined and the width of bone beyond the peak of the anterior glenoid rim was measured. The percent width of this region relative to the anteroposterior diameter of the glenoid was evaluated. Male and female specimens were compared. Measurements of the anteroposterior diameter of the glenoid, both including and excluding this region, were compared. Results: The mean width of bone beyond the peak of the anterior glenoid rim was 3.2 ± 0.7 mm, corresponding to 10.5% of the anteroposterior glenoid diameter. This anatomic region is of similar relative size in males and females (11% vs 10% of the glenoid diameter. Measurement of the anteroposterior diameter of the glenoid is significantly different depending on whether this region is included or not ( P = 0.0064. Conclusions: There exists a portion of the anterior glenoid that is beyond the peak of the anterior rim, and is not part of the concave articular surface. The width of this anatomic area comprises a significant percent of the anteroposterior glenoid diameter, and should be understood when quantifying and describing anterior glenoid bone loss in cases of glenohumeral instability. Clinical Relevance: Understanding of anterior glenoid anatomy is important in the evaluation of glenohumeral instability. The portion of glenoid bone beyond the anterior rim peak is likely important for its soft tissue attachments, but its contribution to bony stability may be misunderstood.

  2. The detection of sclerotic changes of the coronaries and heart valves by scanning beams (ultrafast computed tomography using EVOLUTION)

    With the advent of ultrafast computed tomography the range of diagnostic procedures for the quantitative determination of pathological changes in the coronary arteries has been broadened. The calcified coronary plaques found in this study, which in some of the patients were markedly pronounced, gave no immediate clue as to what extent sclerotic changes had already occurred in the coronaries examined. Nor was it possible on the basis of this method to pinpoint the vascular sections showing calcified plaques in patients undergoing maintenance dialysis. It may, however, permit careful predictions to be made for patients at a high risk of developing coronary artery disease. Sclerotic changes of the heart values occur with above-average frequency in dialysis patients and may be assessed quantitatively by the method described. The results described show that findings revealed by scanning electron beams may provide indirect information on metabolic processes in patients suffering from chronic ailments. (orig./MG)

  3. Rim sign: association with acute cholecystitis

    In a retrospective analysis of 218 hepatobiliary studies in patients clinically suspected of acute cholecystitis, a rim of increased hepatic activity adjacent to the gallbladder fossa (the rim sign) has been evaluated as a scintigraphic predictor of confirmed acute cholecystitis. Of 28 cases with pathologic confirmation of acute cholecystitis in this series, 17 (60%) demonstrated this sign. When associated with nonvisualization of the gallbladder at 1 hr, the positive predictive value of this photon-intense rim for acute cholecystitis was 94%. When the rim sign was absent, the positive predictive value of nonvisualization of the gallbladder at 1 hr for acute cholecystitis was only 36%. As this sign was always seen during the first hour postinjection, it can, when associated with nonvisualization, reduce the time required for completion of an hepatobiliary examination in suspected acute cholecystitis

  4. Tuberous sclerosis with giant renal angiomyolipoma and sclerotic skeletal lesions in a geriatric patient: role of imaging

    Rashmi M. Nagaraju

    2015-08-01

    Full Text Available Tuberous sclerosis is a rare inherited neurocutaneous syndrome, which has multisystem involvement. We present a geriatric female patient with chronic abdominal pain who was diagnosed with giant renal angiomyolipoma (AML and multiple sclerotic skeletal lesions. Radiological imaging played an important role in identifying these two features and diagnosing tuberous sclerosis in our case. [Int J Res Med Sci 2015; 3(8.000: 2145-2149

  5. Three-dimensional trabecular bone architecture of the lumbar spine in bone metastasis from prostate cancer: comparison with degenerative sclerosis

    Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. The objective of this study was to clarify the three-dimensional (3D) trabecular bone microstructure in bone metastasis from prostate cancer by comparison with normal and degenerative sclerotic bone lesions, using microcomputed tomography (micro-CT). A total of 32 cancellous bone samples were excised from the lumbar spine of six autopsy patients: 15 metastatic samples (one patient), eight degenerative sclerotic samples (four patients) and the rest from normal sites (three patients). The samples were serially scanned cross-sectionally by micro-CT with a pixel size of 23.20 μm, slice thickness of 18.56 μm, and image matrix of 512 x 512. Each image data set consisted of 250 consecutive slices. The volumes of interest (96 x 96 x 120 voxels) were defined in the original image sets and 3D indices of the trabecular microstructure were determined. The trabecular thickness (Tb.Th) in degenerative sclerotic lesions was significantly higher than that in normal sites, whereas no significant difference was observed in trabecular number (Tb.N). By contrast, in metastatic lesions, the Tb.N was significantly higher with increased bone volume fraction (BV/TV) than in normal sites, and no significant difference was found in Tb.Th. The characteristics of the trabecular surface in the metastatic samples showed concave structural elements with an increase in BV/TV, indicating osteolysis of the trabecular bone. In 3D reconstructed images, increased trabecular bone with an irregular surface was observed in samples from metastatic sites, which were uniformly sclerotic on soft X-ray radiographs. These results support, through 3D morphological features, the strong bone resorption effect in bone metastasis from prostate cancer. (orig.)

  6. Rim Thickness Factor to Evaluate Fracture Resistance of Spur Gears

    Gonzalo González Rey

    2011-06-01

    Full Text Available In thin rimmed gears running with sufficient bending stress resistance at the tooth-root, fatigue cracks with propagation through the rims, rather than at the tooth fillet, has been observed. Both the ISO and AGMA standards introduce stress-modifying factors (denominated rim thickness factors YB and KB for the bending stress calculation where the rim thickness is not sufficient to provide full support of the tooth root. However, some new experiences and tests of gears have evidenced that the effects of rim thickness on fracture resistance in spur gear are not completely considered with the ISO and AGMA factors for rim thickness. In this paper, some studies published about the effects of rim thickness on spur gear bending stress are reviewed. Moreover, the influence in the rim thickness factor of both rim backup ratio and web thickness ration is confirmed based on statistical analysis and a better formula for calculation of rim thickness factor is proposed.

  7. The Inner Rim Structures of Protoplanetary Discs

    Kama, M; Dominik, C

    2009-01-01

    The inner boundary of protoplanetary discs is structured by the dramatic opacity changes at the transition from the dust-containing to a dust-free zone. This paper explores the variety and limits of inner rim structures in passively heated dusty discs. For this study, we implemented detailed sublimation physics in a fast Monte Carlo radiative transfer code. We show that the inner rim in dusty discs is not an infinitely sharp wall but a diffuse region which may be narrow or wide. Furthermore, high surface densities and large silicate grains as well as iron and corundum grains decrease the rim radius, from a 2.2AU radius for small silicates around a 47 Solar luminosity Herbig Ae star typically to 0.4AU and as close as 0.2AU. A passive disc with grain growth and a diverse dust composition must thus have a small inner rim radius. Finally, an analytical expression is presented for the rim location as a function of dust, disc and stellar properties.

  8. Oscillating Rim Hook Tableaux and Colored Matchings

    Chen, William Y C

    2011-01-01

    Motivated by the question of finding a type B analogue of the bijection between oscillating tableaux and matchings, we find a correspondence between oscillating m-rim hook tableaux and m-colored matchings, where m is a positive integer. An oscillating m-rim hook tableau is defined as a sequence $(\\lambda^0,\\lambda^1,...,\\lambda^{2n})$ of Young diagrams starting with the empty shape and ending with the empty shape such that $\\lambda^{i}$ is obtained from $\\lambda^{i-1}$ by adding an m-rim hook or by deleting an m-rim hook. Our bijection relies on the generalized Schensted algorithm due to White. An oscillating 2-rim hook tableau is also called an oscillating domino tableau. When we restrict our attention to two column oscillating domino tableaux of length 2n, we are led to a bijection between such tableaux and noncrossing 2-colored matchings on $\\{1, 2,..., 2n\\}$, which are counted by the product $C_nC_{n+1}$ of two consecutive Catalan numbers. A 2-colored matching is noncrossing if there are no two arcs of th...

  9. Dependence of rim pore radius on rim porosity and temperature behavior in the high burnup UO2 fuel

    The rim porosity at the high burnup UO2 fuel is obtained at the various rim pore radius ranging from 0.25 to 1.0 μm. The rim pore radius of 1.0 μm gives the best estimation for the rim porosity. With increasing the rim pore radius, thermal conductivity degrades with pellet average burnup because the rim pore acts as the thermal barrier. And by using the NEA database, the culculated fuel centerline temperature considering the rim effect is compared with the experimentally measured NEA database. The calculated temperature predicts reasonably well the temperature behavior of irradiated fuel

  10. Adaptation of subchondral bone in osteoarthritis

    Ding, Ming

    Osteoarthritis is a chronic joint disease with pathological changes in the articulating cartilage and all other tissues that occupy the joint. Radin and coworkers have suggested the involvement of subchondral bone in the disease process. However, evidence for an essential role in the etiology has...... adaptation might explain subchondral stiffening, a process where subchondral bone becomes typically sclerotic in osteoarthritis. In addition, we report reduced mechanical matrix tissue properties as well as an increase in denatured collagen content. In conclusion, although osteoarthritic bone tissue contains...

  11. Histologia e ultraestrutura do rim e rim cefálico do pacu

    Gerlane M. Costa

    2012-05-01

    Full Text Available O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de cada órgão com o uso de microscopia de luz e microscopia eletrônica de transmissão. O resultado da análise macroscópica mostrou que a localização do rim e rim cefálico são as mesmas encontradas na maioria dos teleósteos. O rim apresentou uma forma em "H", onde a região média se expandia sobre a bexiga natatória. O rim cefálico se apresentou como uma dilatação na região cranial do rim, mostrando-se bem visível. Na microscopia eletrônica de transmissão também foram observadas similaridades ultraestruturais com outros teleósteos. Observando nossos resultados concluímos que histologicamente e ultraestruturalmente, os órgãos linfóides rim e rim cefálico de Piaractus mesopotamicus são similares aos de outros teleósteos.

  12. Recent Astronomical Development in Asia Pacific Rim

    Leung, K.-C.

    2009-08-01

    For over two decades The Pacific Rim Conference on Stellar Astrophysics series has been held exclusively at the Asian Rim. The primary reason is that the majority of nations in Asia are less developed in Astronomy than many countries on the American Rim. At time same time, many nations in Asia are less able to afford the costs of long distance travel for astronomical conferences. As a result Asia has had a hold on the Pacific Rim Conferences. Over the last few years new research institutes have been coming on board. The ones that have most visibly emerged are; National Astronomical Research Institute of Thailand, NARIT, The Astrophysical Research Center for the Structure and Evolution of the Cosmos, ARCSEC, and Kavli Institute of Astronomy and Astrophysics at Peking University, KIAA-PKU. It is interesting to note the development and structure of each is very different. So far they all appear to be working well. Hopefully they will provide a variety of models for astronomical institutes in developing nations of the region and perhaps beyond.

  13. Effects of rim thickness on spur gear bending stress

    Bibel, G. D.; Reddy, S. K.; Savage, M.; Handschuh, R. F.

    1991-01-01

    Thin rim gears find application in high-power, light-weight aircraft transmissions. Bending stresses in thin rim spur gear tooth fillets and root areas differ from the stresses in solid gears due to rim deformations. Rim thickness is a significant design parameter for these gears. To study this parameter, a finite element analysis was conducted on a segment of a thin rim gear. The rim thickness was varied and the location and magnitude of the maximum bending stresses reported. Design limits are discussed and compared with the results of other researchers.

  14. Reaction kinetics of dolomite rim growth

    Helpa, V.; Rybacki, E.; Abart, R.; Morales, L. F. G.; Rhede, D.; Jeřábek, P.; Dresen, G.

    2014-04-01

    Reaction rims of dolomite (CaMg[CO3]2) were produced by solid-state reactions at the contacts of oriented calcite (CaCO3) and magnesite (MgCO3) single crystals at 400 MPa pressure, 750-850 °C temperature, and 3-146 h annealing time to determine the reaction kinetics. The dolomite reaction rims show two different microstructural domains. Elongated palisades of dolomite grew perpendicular into the MgCO3 interface with length ranging from about 6 to 41 µm. At the same time, a 5-71 µm wide rim of equiaxed granular dolomite grew at the contact with CaCO3. Platinum markers showed that the original interface is located at the boundary between the granular and palisade-forming dolomite. In addition to dolomite, a 12-80 µm thick magnesio-calcite layer formed between the dolomite reaction rims and the calcite single crystals. All reaction products show at least an axiotactic crystallographic relationship with respect to calcite reactant, while full topotaxy to calcite prevails within the granular dolomite and magnesio-calcite. Dolomite grains frequently exhibit growth twins characterized by a rotation of 180° around one of the equivalent axis. From mass balance considerations, it is inferred that the reaction rim of dolomite grew by counter diffusion of MgO and CaO. Assuming an Arrhenius-type temperature dependence, activation energies for diffusion of CaO and MgO are E a (CaO) = 192 ± 54 kJ/mol and E a (MgO) = 198 ± 44 kJ/mol, respectively.

  15. An insight in to Paget′s disease of bone

    Robin Sabharwal

    2014-01-01

    Full Text Available Paget′s disease of bone (PDB is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. PDB is a focal disorder of bone turnover characterized by excessive bone resorption coupled with bone formation. PDB begins with a period of increased osteoclastic activity and bone resorption, followed by increased osteoblast production of woven bone that is poorly mineralized. In the final phase of the disease process, dense cortical and trabecular bone deposition predominates, but the bone is sclerotic and poorly organized and lacks the structural integrity and strength of normal bone. This article briefly reviews the etiopathogenesis, clinical radiographic and histological features of Paget′s disease.

  16. Aneurysmal bone cyst of the temporal bone

    Aneurysmal bone cyst (ABC) of the temporal bone is rare. The nature of the underlying disorder that converted into the ABC might, however, be difficult to ascertain on imaging as well as on histopathology. The unusual CT and MRI findings in a case of ABC of the temporal bone are presented. This had transdural intracerebral spread with a large component of solid enhancing matrix but no peripheral calcific rim. The patient was an adult of 45 years with a history of headache for more than 1 year Copyright (2004) Blackwell Publishing Asia Pty Ltd

  17. Managing oil logistics around the Baltic Rim

    Finland's Neste Group is a major player in the oil business in the Baltic area. Neste tankers and petroleum product logistics services comprehensively serve the region. Neste's main Baltic Rim terminal outside Finland is located at Muuga close to the Estonian capital, Tallinn. This will be joined by one in Riga in Latvia at the end of this year. A terminal for St. Petersburg is in the planning stage

  18. Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases

    Akira Toriihara; Atsunobu Tsunoda; Akira Takemoto; Kazunori Kubota; Youichi Machida; Ukihide Tateishi

    2015-01-01

    Temporal bone chondroblastoma is an extremely rare benign bone tumor. We encountered two cases showing similar imaging findings on computed tomography (CT), magnetic resonance imaging (MRI), and dual-time-point 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT. In both cases, CT images revealed temporal bone defects and sclerotic changes around the tumor. Most parts of the tumor showed low signal intensity on T2- weighted MRI images and non-uniform enhancement on gadolini...

  19. Negative bone scintigraphy and diffuse osteoblastic breast carcinoma metastases; Scintigraphie osseuse negative et metastases osteocondensantes dans le cancer du sein

    Rousseau, C.; Resche, I.; Chatal, J.F. [Centre Rene Gauducheau, Service de Medecine Nucleaire, 44 - Saint Herblain (France); Campone, M.; Fumoleau, P. [Centre Rene Gauducheau, Service d' Oncologie Medicale, 44 - Saint Herblain (France); Cussac, A. [Centre Rene Gauducheau, Service de Radiotherapie, 44 - Saint Herblain (France); Meingan, P. [Centre Rene Gauducheau, Service d' Imagerie Medicale, 44 - Saint Herblain (France)

    2001-03-01

    The authors report a case of metastatic breast carcinoma with a negative bone scan in spite of densely sclerotic metastases on radiography. The literature is reviewed with regard to the subject of such negative bone scan in this clinical situation and the alternative possibilities to document the diagnostic of breast bone metastases are discussed. The 'normal' scintigraphic pattern is not clearly explained. (authors)

  20. Measurement of wheel rim wear on railway wheels using radioisotopes

    A radioisotopic measuring method developed for studying the wear process of wheel rims of railway vehicles is described. The wear process may be monitored by the measurement of activity of a thin galvanic layer deposited onto the rim and labelled by iron 59. The high sensitivity of the method allows the determination of the wear rate distribution even within a few days. The results of measurements on three different rim profiles are analysed. (R.J.)

  1. Aquaporin-4 expression in distal myopathy with rimmed vacuoles

    Hoshi Akihiko

    2012-04-01

    Full Text Available Abstract Background Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles. To date, the role of aquaporin-4 water channel in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy has not been studied. Case presentation Here, we studied the expression of aquaporin-4 in muscle fibers of a patient with distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy. Immunohistochemical and immunofluorescence analyses showed that sarcolemmal aquaporin-4 immunoreactivity was reduced in many muscle fibers of the patient. However, the intensity of aquaporin-4 staining was markedly increased at rimmed vacuoles or its surrounding areas and in some muscle fibers. The fast-twitch type 2 fibers were predominantly involved with the strong aquaporin-4-positive rimmed vacuoles and TAR-DNA-binding protein-43 aggregations. Rimmed vacuoles with strong aquaporin-4 expression seen in the distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy patient were not found in control muscles without evidence of neuromuscular disorders and the other disease-controls. Conclusions Aquaporin-4 might be crucial in determining the survival or degeneration of fast-twitch type 2 fibers in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy.

  2. Bleomycin-induced epithelial–mesenchymal transition in sclerotic skin of mice: Possible role of oxidative stress in the pathogenesis

    Zhou, Cheng-Fan, E-mail: zhouchengfan@sohu.com [Institute of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022 (China); Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032 (China); Zhou, Deng-Chuan [Department of Emergency Medicine and Critical Care Medicine, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022 (China); Zhang, Jia-Xiang; Wang, Feng; Cha, Wan-Sheng [Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032 (China); Wu, Chang-Hao [Department of Biochemistry and Physiology, Faculty of Health and Medical Sciences, University of Surrey (United Kingdom); Zhu, Qi-Xing, E-mail: zqxing@yeah.net [Institute of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022 (China); Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032 (China)

    2014-06-15

    Epithelial–mesenchymal transition (EMT) derived myofibroblasts are partly responsible for the increased collagen synthesis and deposition that occur in tissue fibrosis; however EMT occurrence in skin fibrosis and its mechanism remain unknown. The aim of this study was to investigate whether epithelial cells undergo EMT and determine the role of oxidative stress in this process. BALB/c mice were subcutaneously injected with bleomycin (BLM) or phosphate buffer saline (PBS) into the shaved back daily for 2, 3, and 4 weeks. Skin collagen deposition was evaluated by histopathology and Western blotting. EMT characteristics in the skin were determined by histopathology and immunofluorescent staining for E-cadherin and vimentin, which were further evaluated by Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR). To investigate the role of oxidative stress in EMT, the antioxidant N-acetylcysteine (NAC) was intraperitoneally (100 mg/kg body weight/day) injected daily for 3 weeks. The epithelial suprabasal cells were detached from the basement membrane zone (BMZ) in the sclerotic skin treated with BLM. Immunofluorescent staining indicated vimentin-positive epithelial cells frequently occurring in the thickened epidermis of BLM-treated mice. Western blotting and RT-PCR showed that the expression of E-cadherin was significantly decreased but that of vimentin significantly increased in the skin treated with BLM. NAC attenuated BLM induced oxidative damage, changes in E-cadherin and vimentin expressions and collagen deposition in the sclerotic skin of mice. This study provides the first evidence that BLM induces the EMT of the epithelial cells superficial to the basement membrane zone in the skin fibrosis. Oxidative stress may contribute, at least in part, to BLM induced EMT and skin fibrosis in mice. - Highlights: • We provided the first evidence that EMT occurred in BLM-induced skin fibrosis. • Epithelial cells superficial to the BMZ underwent EMT in BLM-induced skin fibrosis. • NAC attenuated EMT induction in the process of BLM-induced skin fibrosis. • NAC didn't significantly inhibit TGF-β expression in BLM-induced skin fibrosis.

  3. Bleomycin-induced epithelial–mesenchymal transition in sclerotic skin of mice: Possible role of oxidative stress in the pathogenesis

    Epithelial–mesenchymal transition (EMT) derived myofibroblasts are partly responsible for the increased collagen synthesis and deposition that occur in tissue fibrosis; however EMT occurrence in skin fibrosis and its mechanism remain unknown. The aim of this study was to investigate whether epithelial cells undergo EMT and determine the role of oxidative stress in this process. BALB/c mice were subcutaneously injected with bleomycin (BLM) or phosphate buffer saline (PBS) into the shaved back daily for 2, 3, and 4 weeks. Skin collagen deposition was evaluated by histopathology and Western blotting. EMT characteristics in the skin were determined by histopathology and immunofluorescent staining for E-cadherin and vimentin, which were further evaluated by Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR). To investigate the role of oxidative stress in EMT, the antioxidant N-acetylcysteine (NAC) was intraperitoneally (100 mg/kg body weight/day) injected daily for 3 weeks. The epithelial suprabasal cells were detached from the basement membrane zone (BMZ) in the sclerotic skin treated with BLM. Immunofluorescent staining indicated vimentin-positive epithelial cells frequently occurring in the thickened epidermis of BLM-treated mice. Western blotting and RT-PCR showed that the expression of E-cadherin was significantly decreased but that of vimentin significantly increased in the skin treated with BLM. NAC attenuated BLM induced oxidative damage, changes in E-cadherin and vimentin expressions and collagen deposition in the sclerotic skin of mice. This study provides the first evidence that BLM induces the EMT of the epithelial cells superficial to the basement membrane zone in the skin fibrosis. Oxidative stress may contribute, at least in part, to BLM induced EMT and skin fibrosis in mice. - Highlights: • We provided the first evidence that EMT occurred in BLM-induced skin fibrosis. • Epithelial cells superficial to the BMZ underwent EMT in BLM-induced skin fibrosis. • NAC attenuated EMT induction in the process of BLM-induced skin fibrosis. • NAC didn't significantly inhibit TGF-β expression in BLM-induced skin fibrosis

  4. Histologia e ultraestrutura do rim e rim cefálico do pacu

    Gerlane M. Costa; ANA R DE LIMA; Mendelson G. de Lima; José R Kfoury Jr

    2012-01-01

    O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de...

  5. Rim for rotary inertial energy storage device and method

    Knight, Jr., Charles E. (Knoxville, TN); Pollard, Roy E. (Powell, TN)

    1980-01-01

    The present invention is directed to an improved rim or a high-performance rotary inertial energy storage device (flywheel). The improved rim is fabricated from resin impregnated filamentary material which is circumferentially wound in a side-by-side relationship to form a plurality of discretely and sequentially formed concentric layers of filamentary material that are bound together in a resin matrix. The improved rim is provided by prestressing the filamentary material in each successive layer to a prescribed tension loading in accordance with a predetermined schedule during the winding thereof and then curing the resin in each layer prior to forming the next layer for providing a prestress distribution within the rim to effect a self-equilibrating compressive prestress within the windings which counterbalances the transverse or radial tensile stresses generated during rotation of the rim for inhibiting deleterious delamination problems.

  6. Star Formation in Bright-Rimmed Clouds

    Ballard, Sarah; Allen, L.; Gutermuth, R.

    2006-12-01

    We identify and classify populations of young stellar objects (YSO) in eighteen Bright-Rimmed Clouds (BRC) observed by Spitzer with IRAC (at 3.6, 4.5, 5.8, and 8.0 μm) and MIPS (at 24 and 70 μm). Our sample was selected from the BRC catalogs of Sugitani et al. (1991, Northern Sample, and 1994, Southern Sample). Each cloud in that catalog contains an IRAS point source, evidence that star formation had occurred or is occurring there. We analyze the spatial distribution of the clusters and the types of YSO present, as well as the bolometric luminosity and temperature for sources with good detections at 70 μm. We discuss the correlation between ratio of classes of YSO in the clouds and the evolutionary stage of the cluster. We also investigate bolometric temperature of sources as an indication of evolutionary stage, and find that the results agree with the classifications from color space. Finally, we compare the positions and luminosities of the IRAS point sources with the IRAC and MIPS sources. We find that the luminosities agree to within an order of magnitude.

  7. Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin

    Alexandra Patricia Mena-Serrano

    2013-04-01

    Full Text Available Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI, the 2-step self-etch Adper SE Bond (3MESPE and the 35% phosphoric acid (3MESPE from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE were applied on the bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm 2 and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment, according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05. Results: The duplication of the conditioning time favored only the GO adhesive (p<0.05. Both application methods significantly increased the tubule area opening (p<0.05 compared to the controls. Conclusions: The efficacy of duplicating the conditioning time was only effective for the 1-step self-etch adhesive system tested.

  8. Cholescintigraphic findings of acute cholecystitis emphasized on the rim sign

    Nonvisualization of gallbladder in cholescintigraphy has been established to be a major and reliable finding for acute cholecystitis. A rim of increased pericholecystic hepatic activity (PCHA or Rim sign) in conjunction with gallbladder nonvisualization was reported to be secondary sign of acute cholecystitis. To determine the frequency and significance of the pericholecystic hepatic activity, we evaluated 217 cholescintigram in patients clinically suspected of acute cholecystitis. After brief review of cholescintigraphic findings of acute cholecystitis, the significance of the Rim sign is described. 1) The frequency of the Rim sign in surgically proved acute cholecystitis was 14.9%. 2) The frequency of Rim sign in complicated acute cholecystitis including gallbladder empyema and/or pericholecystic abscess (7/22) and in noncomplicated acute cholecystitis (3/45) was 31.8%, 6.6% respectively. The present study suggests that the Rim sign appear to indicate relatively high incidence of complicated acute cholecystitis and effort should be made observing the presence of the Rim sign in cholescintigraphy.

  9. Business Strategy Analysis of RIM in China's Smartphone Industry

    Chen, Lei

    2011-01-01

    China, the biggest mobile phone market in the world, is crucial for the future of Research In Motion (RIM). While RIM entered China’s market in 2006, its market share is still very small in China. The launch of 3G amid the restructuring of China’s telecom industry proved crucial to the company’s development. RIM has partnered with all mobile operators in China to provide BlackBerry Enterprise Service and BlackBerry Internet Service to both business and individual users. It has gained a compet...

  10. Secondary Aneurysmal Bone Cystic Change of the Chondroblastoma, Mistaken for a Primary Aneurysmal Bone Cyst in the Patella

    Chung, Jin Wha; Lee, Hwa Sung

    2014-01-01

    A 29-year-old woman complained of a 3-month history of left knee pain without trauma history. X-ray showed a well-defined osteolytic lesion with a sclerotic margin in the patella and magnetic resonance imaging showed T1-low and T2-high signal intensity with different fluid level. Our impression was an aneurysmal bone cyst. At surgery, the lesion was a blood-filled cystic cavity, surrounded by a gray or brownish tissue. Hemorrhagic soft tissues with recognizable bone fragments were observed. C...

  11. Learning from California and the Pacific Rim

    Heavy oils are found in 10 of the 14 largest oilfields in Alaska and California. In the US west coast region, petroleum demand is dominated by light transport fuels, and there is a lack of a discrete and conspicuous heavy oil market. The structure and behavior of west coast petroleum markets, and their interactions with crude-oil and petroleum product markets elsewhere on the Pacific Rim are discussed with regard to how the market for growing volumes of western Canadian heavy oils might evolve. An analysis of crude oil prices versus API gravity demonstrates the price penalties on oil of low gravity, high sulfur, and high transport cost. Prices at the high gravity end tend to correlate closely with Asian light crude and unfinished gasoline prices. The heaviest crudes are priced in competition with other chemically similar residual oils for direct fuel use, blending, or refinery feedstock. The biggest component of the west coast heavy oil market is bunker fuel. The market value of heavy crudes in the west coast is thus determined by regional supply and demand for heavy hydrocarbon molecules, whatever the source. The west coast is not a promising market for Canadian heavy crudes, and exports to Asia would have to compete both with residual oils from Asia and the US west coast and with California heavy crudes. US west coast production peaked in 1989 and regional production can be expected to decline further in average gravity. New production from known but undeveloped heavy oil pools near Prudhoe Bay or in the California offshore could be expected to postpone the need for imports to the west coast and to depress prices. A removal of the Alaska crude oil export ban could improve the west coast heavy oil market. 5 refs., 2 figs., 1 tab

  12. Bone tumors with an associated pathologic fracture: Differentiation between benign and malignant status using radiologic findings

    Bae, Ji Hyun; Lee, In Sook; Song, You Seon [Pusan National University School of Medicine, Pusan National University Hospital, Busan (Korea, Republic of); Kim, Jeung Il [Dept. of Radiology, Yeungnam University College of Medicine, Yeungnam University Medical Center, Daegu (Korea, Republic of); Lee, Moon Sung [Dept. of Radiology, Keimyung University College of Medicine, Dongsan Medical Center, Daegu (Korea, Republic of); Lee, Young Hwan [Dept. of Radiology, Catholic University of Daegu College of Medicine, Daegu Catholic University Hospital, Daegu (Korea, Republic of); Song, Jong Woon [Dept. of Radiology, Inje University College of Medicine, Haeundae Paik Hospital, Busan (Korea, Republic of)

    2015-10-15

    To determine whether benign and malignant bone tumors with associated pathologic fractures can be differentiated using radiologic findings. Seventy-eight patients (47 men and 31 women, age range: 1-93 years) with a bone tumor and an associated pathologic fracture from 2004 to 2013 constituted the retrospective study cohort. The tumor size, margin, and enhancement patterns; the presence of sclerotic margin, the peritumoral bone marrow, soft tissue edema, extra-osseous soft tissue mass, intratumoral cystic/hemorrhagic/necrotic regions, mineralization/sclerotic regions, periosteal reaction and its appearance; and cortical change and its appearance were evaluated on all images. Differences between the imaging characteristics of malignant and benign pathologic fractures were compared using Pearson's chi-square test and the 2-sample t-test. There were 22 benign and 56 malignant bone tumors. Some factors were found to significantly differentiate between benign and malignant tumors; specifically, ill-defined tumor margin, the presence of sclerotic tumor margin and an extra-osseous soft tissue mass, the absence of cystic/necrotic/hemorrhagic portions in a mass, the homogeneous enhancement pattern, and the presence of a displaced fracture and of underlying cortical change were suggestive of malignant pathologic fractures. Some imaging findings were helpful for differentiating between benign and malignant pathologic fractures.

  13. Bone tumors with an associated pathologic fracture: Differentiation between benign and malignant status using radiologic findings

    To determine whether benign and malignant bone tumors with associated pathologic fractures can be differentiated using radiologic findings. Seventy-eight patients (47 men and 31 women, age range: 1-93 years) with a bone tumor and an associated pathologic fracture from 2004 to 2013 constituted the retrospective study cohort. The tumor size, margin, and enhancement patterns; the presence of sclerotic margin, the peritumoral bone marrow, soft tissue edema, extra-osseous soft tissue mass, intratumoral cystic/hemorrhagic/necrotic regions, mineralization/sclerotic regions, periosteal reaction and its appearance; and cortical change and its appearance were evaluated on all images. Differences between the imaging characteristics of malignant and benign pathologic fractures were compared using Pearson's chi-square test and the 2-sample t-test. There were 22 benign and 56 malignant bone tumors. Some factors were found to significantly differentiate between benign and malignant tumors; specifically, ill-defined tumor margin, the presence of sclerotic tumor margin and an extra-osseous soft tissue mass, the absence of cystic/necrotic/hemorrhagic portions in a mass, the homogeneous enhancement pattern, and the presence of a displaced fracture and of underlying cortical change were suggestive of malignant pathologic fractures. Some imaging findings were helpful for differentiating between benign and malignant pathologic fractures

  14. Peter Rim appointed Joseph H. Collie Professor of Chemical Engineering

    Owczarski, Mark

    2010-01-01

    Peter Rim of Midlothian, Va., professor of chemical engineering in the College of Engineering at Virginia Tech, was recently appointed the Joseph H. Collie Professor of Chemical Engineering by the Virginia Tech Board of Visitors.

  15. Hemangioendotelioma Hepático Infantil e Rim Displásico Multiquístico: uma nova associação?

    M. Carneiro de Moura

    2009-03-01

    Full Text Available O hemangioendotelioma hepático infantil tem uma incidência que é a terceira entre os tumores hepáticos da criança e é o tumor benigno hepático vascular mais frequente na infância. Apresentamos o caso clínico de uma criança com o diagnóstico de hemangioendotelioma hepático associado a rim displásico multiquístico transitório. O diagnóstico de rim multiquístico foi confirmado por ecografia no período pré e pós natal. Numa ecografia realizada aos 5 meses detectaram-se lesões hepáticas sugestivas de hemangioendotelioma. Realizou ressonância magnética aos 8 meses que não mostrou o rim direito. A biópsia hepática confirmou o diagnóstico de hemangioendotelioma infantil tipo1. Em ecografias seriadas verificou-se redução das lesões hepáticas que desapareceram aos 19 meses. Esta associação de hemangioendotelioma hepático e rim multiquístico não se encontra descrita, embora sejam conhecidas associações com agenesia renal.

  16. Rimmed and edge thickened stodola shaped flywheel. [Patent application

    Kulkarni, S.V.; Stone, R.G.

    1980-09-24

    A flywheel is described that is useful for energy storage in a hybrid vehicle automotive power system or in some stationary applications. The flywheel has a body composed of essentially planar isotropic high strength material. The flywheel body is enclosed by a rim of circumferentially wound fiber embedded in resin. The rim promotes flywheel safety and survivability. The flywheel has a truncated and edge thickened Stodola shape designed to optimize system mass and energy storage capability.

  17. Rim instability in dewetting of thin polymer films

    Marquant, Ludovic

    2013-01-01

    Understanding flow properties at the solid/liquid interface is important for numerous of technological applications in nanotechnology and microfluidic. The strong scientific interest in the field of thin liquid films led to new conclusions on the impact of hydrodynamic slippage on the dewetting dynamics and on the shape of the rim growing at the three phase contact line. This work consists of verifying the validity of these findings at late stage of dewetting, i.e. while the rim instabilit...

  18. A STUDY OF HAEMOGLOBIN PATTERNS AMONG THE STUDENTS OF RIMS

    Urmila; Sunita,; Mohen Singh; Durlav Chandra

    2015-01-01

    Haemoglobinopathies are a major health problem worldwide. Because of the high prevalence of these disorders in India and especially in North–East, we undertook this limited student based study as RIMS comprised students from the seven North-East states of Arunachal Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Sikkim and Tripura. AIMS: To study the prevalence of haemoglobin variants among the North-East students of RIMS and to find out any abnormal haemoglobin pattern pertai...

  19. Novel Multiband Metal-Rimmed Antenna for Wearable Applications

    Bin Liu; Jianghong Han; Songhua Hu; Li De Zhang

    2015-01-01

    A novel multiband antenna with an unbroken metal rim for wearable applications is presented. In order to achieve a wideband behavior, minimizing at the same time the size of the clearance area on the antenna ground plane, a novel feeding structure is proposed. This is achieved by connecting the metal rim to the ground plane thus allowing generating one lower-frequency resonance without occupying a large area. An additional resonance is then obtained using a suitable shorting patch. In this wa...

  20. Radiographic features of asymptomatic bone ingrowth hip prostheses

    The radiographic changes in asymptomatic patients with bone ingrowth hip prostheses have not been well documented. The authors reviewed films of 85 bone ingrowth femoral components in 77 asymptomatic patients with an average postoperative follow-up time of 21.8 months. The findings in decreasing order of frequency included (1) stress shielding effect with resorption and rounding of bone in the proximal and medial femoral shaft (98%), (2) linear lucency (2 mm or less in width) with a thin sclerotic margin adjacent to the prosthesis proximally and/or distally (79%), (3) endosteal sclerosis at the prosthesis tip (36%), (4) heterotopic bone (24%) (5) cortical thickening at the tip of the prosthesis (12%), and (6) prosthetic subsidence (7%). The periprosthetic lucencies represent fibrous rather than bone ingrowth. Patients with fibrous ingrowth have good functional results, and this radiographic finding should not be confused with prosthetic loosening

  1. Southern rim of Isidis Planitia basin

    2002-01-01

    (Released 11 April 2002) The Science This image, crossing the southern rim of the Isidis Planitia basin, displays the contrasting morphologies of the relatively rough highland terrain (in the lower portion of the image) and the relatively smooth materials of the basin (at top). Upon closer viewing, the basin materials display an extensive record of cratering, including a small cluster of craters just north and west of the two prominent craters in the upper part of the image. This cluster of craters may represent what are called 'secondary' craters, which are craters that form as a result of the ejection of debris from a nearby impact. Alternatively, these craters may have formed simultaneously by the impact of many pieces of a larger meteoroid that broke up upon entry into Mars' atmosphere. The large craters in the image are approximately 800 meters (875 yards) in diameter. Also visible in the image are dark streaks on the east-facing side of the north-south trending ridge. These streaks are likely the result of debris movement down slope. A dark patch of material is visible at the left of the image; dark materials are typically mobile sands, and linear dune forms are apparent within the dark patch. The Story Battered and beaten up, the surface of Mars reads like a history book to geologists, who want to study what has happened to the red planet over its geological history. Look for two larger craters diagonal from one another in the northern part of this image, and then for the smattering of tinier craters near them. How did these smaller craters come to be? Did a large meteoroid streak in through the Martian atmosphere and get broken up as it passed through, pummeling Mars moments later with its smaller, scattered pieces? Or were rocks and dirt blasted off the surface when the two larger craters were formed, only to rain down again on Mars shortly afterwards? No one quite knows for sure.... Another enigmatic-looking feature is near the left center of this image. Dark and shadowy-seeming, it looks something like an exclamation point with the small crater just below it. Look closely, and you'll see dunes within the large, dark, blurry patch, which is itself probably composed of moving sands. Dark, streaky features also appear on the eastern side of the ridge that runs down the right side of the image, showing how debris once tumbled down its steepened slopes.

  2. Rim region growth and its composition in reaction bonded boron carbide composites with core-rim structure

    Aluminum was detected in reaction-bonded boron carbide that had been prepared by pressureless infiltration of boron carbide preforms with molten silicon in a graphite furnace under vacuum. The presence of Al2O3 in the heated zone, even though not in contact with the boron carbide preform, stands behind the presence of aluminium in the rim region that interconnects the initial boron carbide particles. The composition of the rim corresponds to the Bx(C,Si,Al)y quaternary carbide phase. The reaction of alumina with graphite and the formation of a gaseous aluminum suboxide (Al2O) accounts for the transfer of aluminum in the melt and, subsequently in the rim regions. The presence of Al increases the solubility of boron in liquid silicon, but with increasing aluminum content the activity of boron decreases. These features dominate the structural evolution of the rim-core in the presence of aluminum in the melt.

  3. Rim region growth and its composition in reaction bonded boron carbide composites with core-rim structure

    Hayun, S.; Weizmann, A.; Dilman, H.; Dariel, M. P.; Frage, N.

    2009-06-01

    Aluminum was detected in reaction-bonded boron carbide that had been prepared by pressureless infiltration of boron carbide preforms with molten silicon in a graphite furnace under vacuum. The presence of Al2O3 in the heated zone, even though not in contact with the boron carbide preform, stands behind the presence of aluminium in the rim region that interconnects the initial boron carbide particles. The composition of the rim corresponds to the Bx(C,Si,Al)y quaternary carbide phase. The reaction of alumina with graphite and the formation of a gaseous aluminum suboxide (Al2O) accounts for the transfer of aluminum in the melt and, subsequently in the rim regions. The presence of Al increases the solubility of boron in liquid silicon, but with increasing aluminum content the activity of boron decreases. These features dominate the structural evolution of the rim-core in the presence of aluminum in the melt.

  4. A new flea, Ectinorus (Ectinorus) insignis n. sp. (Siphonaptera, Rhopalopsyllidae, Parapsyllinae), with notes on the subgenus Ectinorus in Chile and comments on unciform sclerotization in the superfamily Malacopsylloidea

    2013-01-01

    A list is provided for the species of Ectinorus sensu stricto from Chile. Ectinorus (Ectinorus) insignis n. sp. is described from Chile: this species is characterized by the male genitalia. In the subgenus Ectinorus, the authors report the presence in Chile of E. pilosus Beaucournu & Carmen Castro, 2002 described from Argentina and E. simonsi (Rothschild, 1904) described from Bolivia but also known from Peru. A female neallotype is designated for E. ineptus Johnson, 1957. “Unciform sclerotization” is noted and illustrated for the first time, in all Malacopsylloidea, and a list is given for all studied species. PMID:24125080

  5. A new flea, Ectinorus (Ectinorus) insignis n. sp. (Siphonaptera, Rhopalopsyllidae, Parapsyllinae), with notes on the subgenus Ectinorus in Chile and comments on unciform sclerotization in the superfamily Malacopsylloidea.

    Beaucournu, Jean-Claude; Belaz, Sorya; Muñoz-Léal, Sebastián; González-Acuña, Daniel

    2013-01-01

    A list is provided for the species of Ectinorus sensu stricto from Chile. Ectinorus (Ectinorus) insignis n. sp. is described from Chile: this species is characterized by the male genitalia. In the subgenus Ectinorus, the authors report the presence in Chile of E. pilosus Beaucournu & Carmen Castro, 2002 described from Argentina and E. simonsi (Rothschild, 1904) described from Bolivia but also known from Peru. A female neallotype is designated for E. ineptus Johnson, 1957. "Unciform sclerotization" is noted and illustrated for the first time, in all Malacopsylloidea, and a list is given for all studied species. PMID:24125080

  6. Bone scintigraphy, radiography and MRI in the diagnosis and evaluation of treatment response of calcaneal tuberculosis

    Aim: We describe the role of various imaging modalities in the diagnosis and follow up of calcaneal tuberculosis. Materials and methods: Six patients (5 males, 1 female; age range 16-49 years) presented with heel pain. All patients underwent routine laboratory and radiological investigations e.g. radiographs, MRI and skeletal scintigraphy as part of initial diagnostic work-up. In all patients the diagnosis of tuberculosis was confirmed based on histopathology or culture. Standard multi-drug anti-tubercular therapy (ATT) was administered for 15 months. All patients were subsequently followed up with clinical evaluation, laboratory investigations and imaging. Skeletal scintigraphy, MRI and radiographs were repeated at 12 to 15 months from the initiation of anti-tubercular treatment in all patients. Results: Five out of six patients had lytic lesions at presentation on radiographs. Four of these 5 patients also had surrounding sclerosis. Follow-up radiographs obtained 12-15 months after starting ATT, showed an increase in surrounding sclerosis with progressive reduction in area of osteopenia in four and mild sclerotic changes in one. In the remaining one patient radiograph were normal both at presentation and follow up. Three phase bone scintigraphy revealed increased blood flow and blood pool activity and 'hot spots' in 5 and a central photopenic area in the calcaneum in one patient at the time of diagnosis. After starting ATT, significant reduction in vascularity and reactive bone changes in 5 patients and mild improvement in one patient. MRI was done in three patients, which revealed hyperintense lesion with erosion of the superior articular surface in 2 and 'Bull's eye' lesion with a hypointense centre and a surrounding hyperintense rim on post contrast T1W images in one patient. Follow-up MRI showed intermediate signal intensity on T2 weighted images that corresponded to caseous necrosis and high signal intensity related to granulomas or effusion. Conclusion: Radiography alone may not always reveal the presence of disease or its activity in calcaneal tuberculosis. Skeletal scintigraphy has a promising role in the early detection of calcaneal tuberculosis, and in the subsequent follow-up. It also offers the added advantage of whole body screening to detect multiple foci. MRI seems to offer similar sensitivity and better specificity in the diagnosis and follow-up compared to skeletal scintigraphy. MRI also offers better characterization of tubercular lesions

  7. Aqueous Alteration of Endeavour Crater Rim Apron Rocks

    Ming, D. W.; Mittlefehldt, D. W.; Gellert, R.; Clark, B. C.; Morris, R. V.; Yen, A. S.; Arvidson, R. E.; Crumpler, L. S.; Farrand, W. H.; Grant, J. A., III; Jolliff, B. L.; Parker, T. J.; Peretyazhko, T.

    2014-12-01

    Mars Exploration Rover Opportunity is exploring Noachian age rocks of the rim of 22 km diameter Endeavour crater. Overlying the pre-impact lithologies and rim breccias is a thin apron of fine-grained sediments, the Grasberg fm, forming annuli on the lower slopes of rim segments. Hesperian Burns fm sandstones overly the Grasberg fm. Grasberg rocks have major element compositions that are distinct from Burns fm sandstones, especially when comparing interior compositions exposed by the Rock Abrasion Tool. Grasberg rocks are also different from Endeavour rim breccias, but have general compositional similarities to them. Grasberg sediments are plausibly fine-grained materials derived from the impact breccias. Veins of CaSO4 transect Grasberg fm rocks demonstrating post-formation aqueous alteration. Minor/trace elements show variations consistent with mobilization by aqueous fluids. Grasberg fm rocks have low Mn and high Fe/Mn ratios compared to the other lithologies. Manganese likely was mobilized and removed from the Grasberg host rock by redox reactions. We posit that Fe2+ from acidic solutions associated with formation of the Burns sulfate-rich sandstones acted as an electron donor to reduce more oxidized Mn to Mn2+. The Fe contents of Grasberg rocks are slightly higher than in other rocks suggesting precipitation of Fe phases in Grasberg materials. Pancam spectra show that Grasberg rocks have a higher fraction of ferric oxide minerals than other Endeavour rim rocks. Solutions transported Mn2+ into the Endeavour rim materials and oxidized and/or precipitated it in them. Grasberg has higher contents of the mobile elements K, Zn, Cl, and Br compared to the rim materials. Similar enrichments of mobile elements were measured by the Spirit APXS on West Spur and around Home Plate in Gusev crater. Enhancements in these elements are attributed to interactions of hydrothermal acidic fluids with the host rocks. Interactions of fluids with the Grasberg fm postdate the genesis of the Endeavour rim phyllosilicates. The aqueous alteration history of Endeavour rim rocks is complicated by different styles of alteration that have spanned the Noachian and Hesperian. Late stage acidic aqueous alteration of Grasberg fm materials is likely penecontemporaneous with the diagenesis of the sulfate-rich sediments of Meridiani Planum.

  8. Aqueous Alteration of Endeavour Crater Rim Apron Rocks

    Mittlefehldt, David W.; Ming, Douglas W.; Gellert, Ralf; Clark, Benton C.; Morris, Richard V.; Yen, Albert S.; Arvidson, Raymond E.; Crumpler, Larry S.; Farrand, William H.; Grant, John A.; Jolliff, Bradley L.; Parker, Timothy J.; Peretyazhko, Tanya

    2014-01-01

    Mars Exploration Rover Opportunity is exploring Noachian age rocks of the rim of 22 km diameter Endeavour crater. Overlying the pre-impact lithologies and rim breccias is a thin apron of fine-grained sediments, the Grasberg fm, forming annuli on the lower slopes of rim segments. Hesperian Burns fm sandstones overly the Grasberg fm. Grasberg rocks have major element compositions that are distinct from Burns fm sandstones, especially when comparing interior compositions exposed by the Rock Abrasion Tool. Grasberg rocks are also different from Endeavour rim breccias, but have general compositional similarities to them. Grasberg sediments are plausibly fine-grained materials derived from the impact breccias. Veins of CaSO4 transect Grasberg fm rocks demonstrating post-formation aqueous alteration. Minor/trace elements show variations consistent with mobilization by aqueous fluids. Grasberg fm rocks have low Mn and high Fe/Mn ratios compared to the other lithologies. Manganese likely was mobilized and removed from the Grasberg host rock by redox reactions. We posit that Fe2+ from acidic solutions associated with formation of the Burns sulfate-rich sandstones acted as an electron donor to reduce more oxidized Mn to Mn2+. The Fe contents of Grasberg rocks are slightly higher than in other rocks suggesting precipitation of Fe phases in Grasberg materials. Pancam spectra show that Grasberg rocks have a higher fraction of ferric oxide minerals than other Endeavour rim rocks. Solutions transported Mn2+ into the Endeavour rim materials and oxidized and/or precipitated it in them. Grasberg has higher contents of the mobile elements K, Zn, Cl, and Br compared to the rim materials. Similar enrichments of mobile elements were measured by the Spirit APXS on West Spur and around Home Plate in Gusev crater. Enhancements in these elements are attributed to interactions of hydrothermal acidic fluids with the host rocks. Interactions of fluids with the Grasberg fm postdate the genesis of the Endeavour rim phyllosilicates. The aqueous alteration history of Endeavour rim rocks is complicated by different styles of alteration that have spanned the Noachian and Hesperian. Late stage acidic aqueous alteration of Grasberg fm materials is likely penecontemporaneous with the diagenesis of the sulfate-rich sediments of Meridiani Planum.

  9. Intraosseous lipoma of the iliac: case report☆

    de Moraes, Frederico Barra; Paranahyba, Rodrigo Marques; do Amaral, Rogério Andrade; Bonfim, Vinícius Mendes; Jordão, Nathalya Ducarmo; Souza, Raimundo Djalma

    2016-01-01

    Lipomas are benign tumors that attack fat cells and most often affecting soft tissues in adulthood. On rare occasions, they may affect bones, preferentially the metaphyses of the long bone. They are generally asymptomatic and radiography shows radiolucent lesions with a thin sclerotic rim or radiodense lesions with a thick sclerotic rim. Malignant transformation of these tumors is rare, as is their recurrence, and there is no need for surgery in most cases. In this report, we present a rare case of intraosseous lipoma in the iliac bone. PMID:26962507

  10. Formation of the rim structure in high burnup fuel

    The process of grain subdivision or polygonization in UO2 was studied by using ion irradiation techniques and by investigating the rim structure in high burnup UO2 fuel. Ion irradiation with fission product ions caused first the formation of subgrain boundaries, observed in high resolution transmission electron microscopy, HRTEM. At higher doses, polygonization was completed at a well defined threshold. High burnup UO2 fuel showing well developed rim zones was investigated in optical, scanning and transmission electron microscopy. The oxygen potential ? anti G(O2), the hardness H and the fracture toughness KIc of the restructured material and the radial dependence of porosity, grain subdivision, H and KIc were measured. KIc was found to change at smaller radial positions than the other properties, indicating a nucleation process not affecting all properties to the same extent. The emerging picture for the formation of the rim structure in UO2 is discussed. (orig.)

  11. Pacific Rim coal trade model for U.S. involvement

    The world contains 700 billion tons of coal reserves mineable by today's technical standards with the United States having one-third of the total. Coal demand of the Pacific Rim will grow very rapidly in the next decade due to expanded use of coal to produce electricity and steel. Imported 1989 coal supply to the Pacific Rim was from Australia (50%), Canada (18%), U.S. (13%), South Africa (7%), U.S.S.R. (6%), China (4%) and Indonesia (1%). The U.S. coal price will continue to trend downward due to increasing mine productivity. The world is moving toward a transnational economy. Groups of nations are forming economic ties and cooperation. This paper reports that the U.S. can increase involvement in the Pacific Rim coal markets by offering value-added coal sales transactions and by understanding Orient culture

  12. Parosteal osteoma of the iliac bone

    Soler, R.R.; Martinez, S.; Granados, J. [Department of Rheumatology, Hospital Mutua de Terrassa, Barcelona (Spain); de Marcos, J.A. [Department of Radiology, Hospital Mutua de Terrassa, Barcelona (Spain); Salas, A. [Department of Pathology, Hospital Mutua de Terrassa, Barcelona (Spain); Lluc, P. [Primary Care Setting, Sa Canal Salat, Menorca (Spain)

    1998-03-01

    A 33-year-old patient with a 2-year history of intermittent pain in the right gluteal region and thigh presented with a large sclerotic lesion of the iliac bone. From the findings on radiography, scintigraphy, CT and MRI, a giant parosteal osteoma was suspected. The histological examination confirmed the diagnosis. Since the lesion was extensive it was observed with periodic follow-up examinations. At present, 5 years after the diagnosis, the patient is asymptomatic and imaging studies show that the lesion persists with reduction of sclerosis and size. The tumor was on the surface as well as intramedullary - only one other case with such a distribution is known to us - and it was also in the iliac bone. (orig.) With 7 figs., 14 refs.

  13. Experimental study of THGEM detector with mini-rim

    Zhang, Ai-Wu; Xie, Yu-Guang; Liu, Hong-Bang; An, Zheng-Hua; Wang, Zhi-Gang; Cai, Xiao; Sun, Xi-Lei; Shi, Feng; Fang, Jian; Xue, Zhen; Lu, Qi-Wen; Sun, Li-Jun; Ge, Yong-Shuai; Liu, Ying-Biao; Hu, Tao; Zhou, Li; Lu, Jun-Guang

    2011-01-01

    The gas gain and energy resolution of single and double THGEM detectors (5{\\times}5cm2 effective area) with mini-rims (rim is less than 10{\\mu}m) were studied. The maximum gain can reach 5{\\times}103 and 2{\\times}105 for single and double THGEM respectively, while the energy resolution of 5.9 keV X-ray varied from 18% to 28% for both single and double THGEM detectors of different hole sizes and thicknesses.All the experiments were investigated in mixture of noble gases(argon,neon) and small content of other gases(iso-butane,methane) at atmospheric pressure.

  14. Lower-Rim Substituted Calixarenes and Their Applications

    Princy Jose

    2007-03-01

    Full Text Available This review discusses in detail “calixarenes” since their discovery as by-products of the phenol formaldehyde bakelites till the present scenario wherein calixarene has assumed a new dimension in the field of supramolecular chemistry. Extensive literature exists for calixarenes; but herein we have tried to concentrate on the different lower-rim modified calixarenes with their potential applications. An attempt has also been made to critically evaluate the synthesis procedures for different lower-rim substituted calixarenes.

  15. Performance of Non-Cemented, Hemispherical, Rim-Fit, Hydroxyapatite Coated Acetabular Component.

    John, Thomas K; Ghosh, Gaurav; Ranawat, Chitranjan S; Ranawat, Amar S; Meftah, Morteza

    2015-12-01

    The purpose of this study was to assess the durability of a non-cemented, hemispherical rim-fit, hydroxyapatite coated cup with a highly cross-linked polyethylene in 223 total hip arthroplasties. At 6-years follow-up (range, 5-9), there were no cup revisions for osteolysis or loosening. Radiologic evidence of osseointegration was based on presence of Stress Induced Reactive Cancellous Bone and radial trabeculae, seen in 47% and 93% of cups, respectively; both were most prevalent in Zone 1. There was no interference demarcation in any zones. Two cups were revised (0.9%): one for dislocation and another for infection. The Kaplan-Meier survivorship for cup revision for any failure (infection, dislocation) was 99% and for mechanical failure (osteolysis, loosening) was 100%. This design has excellent safety, efficacy and durability. PMID:26235521

  16. Imaging signs and diagnosis of bone echinococcosis

    Objective: To evaluate the value of imaging investigations in the diagnosis of bone echinococcosis by analysing the X-ray, CT and MBI signs. Methods: Imaging data of 7 patients aged from 23 to 56 years ( mean age 39.5 years) with bone echinococcosis were analysed retrospectively. All cases underwent X-ray plain film examination (frontal view and lateral view); 4 cases were examined with CT; 3 cases received MRI scan. Results: The echinococcosis located in skull (1 case), vertebrae (3 cases), sacrum (1 case), ilium(1 case )and ribs (1 case) respectively. X-ray signs: 5 cases appeared as expanding destructive lesion, two of them were solitary cystic lesions, the others were multiple cystic lesions. Lyric destruction was showed in 2 cases. Sclerotic margin, calcification, soft tissue mass was visible in 5, 1 and 4 cases respectively. CT signs: 3 of 4 cases were expanding destructive lesions, including 2 multiple cystic lesions and 1 solitary cystic destruction. The other one showed lytic destruction. 3 had sclerotic margin; calcification was identified in 2 cases, 4 cases accompanied with soft tissue mass. MRI signs: All of 3 cases occurred at vertebrae, solitary cystic lesion in one and multiple cystic lesions in two. Lesions showed low signal on T1WI image, high signal on T2WI image and appeared as grape shapes. Involved vertebrae showed wedge-shaped. Conclusion: Imaging modalities were significantly valuable in the diagnosis of bone echinococcosis. Combination of X-ray radiography, CT, MRI and epidemiological information is helpful in the diagnosis and differential diagnosis of the bone echinococcosis. (authors)

  17. Effect of Er,Cr:YSGG Laser at Different Output Powers on the Micromorphology and the Bond Property of Non-Carious Sclerotic Dentin to Resin Composites

    Wang, Weiguo; Jiao, Yang; Wang, Wanshan; Yang, Yanwei; Wei, Jingjing; Shen, Lijuan; Chen, Jihua

    2015-01-01

    Background The objective of this study was to investigate the influence of Er,Cr:YSGG laser irradiated at different powers on the micromorphology and the bonding property of non-carious sclerotic dentin to resin composites. Methods Two hundred bovine incisors characterized by non-carious sclerotic dentin were selected, and the seventy-two teeth of which for surface morphological analysis were divided into nine groups according to various treatments (A: the control group, B: only treated with the adhesive Adper Easy One, C: diamond bur polishing followed by Adper Easy One, D-I: Er,Cr:YSGG laser irradiating at 1W, 2W, 3W, 4W, 5W, 6W output power, respectively, followed by Adper Easy One). The surface roughness values were measured by the non-contact three-dimensional morphology scanner, then the surface micromorphologies of surfaces in all groups were assessed by scanning electron microscopy (SEM); meanwhile, Image Pro-Plus 6.0 software was used to measure the relative percentage of open tubules on SEM images. The rest, one hundred twenty-eight teeth for bond strength test, were divided into eight groups according to the different treatments (A: only treated with the adhesive Adper Easy One, B: diamond bur polishing followed by the above adhesive, C-H: Er,Cr:YSGG laser irradiating at 1 W, 2 W, 3 W, 4 W, 5 W, 6 W output power, respectively, followed by the above adhesive), and each group was subsequently divided into two subgroups according to whether aging is performed (immediately tested and after thermocycling). Micro-shear bond strength test was used to evaluate the bond strength. Results The 4W laser group showed the highest roughness value (30.84±1.93μm), which was statistically higher than the control group and the diamond bur groups (plaser group showed the highest micro-shear bond strength not only in immediately tested (17.60±2.55 PMa) but after thermocycling (14.35±2.08MPa). Conclusion The Er,Cr:YSGG laser at 4W power can effectively improve the bonding property between non-carious sclerotic dentin and resin composites by increasing the roughness and mean percentage area of open tubules. PMID:26544034

  18. Ultrasensitive analysis of thorium by resonance ionization mass spectroscopy (RIMS)

    This communication presents results on a RIMS analysis of thorium. Thorium is of interest for geochronological and geochemical purposes. The measurement of uranium series disequilibrium is a well established and valuable approach for geochronological studies: disequilibrium between 234/238U and 230Th can be used to date samples younger than 350,000 years. Both continuous wave (cw) and pulsed lasers were utilized in this study for resonantly exciting and subsequently ionizing thorium. In the case of the pulsed laser RIMS experiments, two excimer laser-pumped dye lasers were used in conjunction with a 0.4 m time-of-flight mass spectrometer. The cw RIMS experiments used an Ar+ laser-pumped dye laser and a second Ar+ in combination with a single magnetic sector mass spectrometer (NBS 12-90 design). Experiments performed with the pulsed RIMS apparatus were aimed at determining the autoionization state structure and re-determining the ionization potential (IP). By tuning one dye laser to a resonance and scanning the second laser such that the total energy was equal to or above the IP, over 150 autoionization states were determined. The IP was re-determined to be 6.211±.002 eV (50900 ± 20 cm-1). In addition, the typical cross section for ionization of an autoionizing state was determined to be 1 x 10-15 cm2

  19. Time course of X-ray pecture of thyroid cancer metstases to the bones resulting from radiotherapy effects

    Teletherapy or radiotherapy combined with 131I for thyroid cancer metastases to the bones caused the development of bone reparation in 70%, in 17% the picture remained unchanged; signs of further tumor growth were observed in 13%. An early X-ray sign of therapeutic efficacy was the decreased soft tissue component of a metastatic tumor 3-5 mos after the initiation of therapy. Disease stabilization was observed in 2.5-3 yrs. X-ray manifestations of bone reparation looked as sclerotic changes along the periphery of a focus of lesion and depended on the sizes of a metastasis and its localization in the skeleton

  20. Rim region growth and its composition in reaction bonded boron carbide composites with core-rim structure

    Hayun, S; Weizmann, A; Dilman, H; Dariel, M P; Frage, N [Department of Materials Engineering, Ben-Gurion University of the Negev, P. O. Box 653, Beer-Sheva 84105 (Israel)], E-mail: hayuns@bgu.ac.il

    2009-06-01

    Aluminum was detected in reaction-bonded boron carbide that had been prepared by pressureless infiltration of boron carbide preforms with molten silicon in a graphite furnace under vacuum. The presence of Al{sub 2}O{sub 3} in the heated zone, even though not in contact with the boron carbide preform, stands behind the presence of aluminium in the rim region that interconnects the initial boron carbide particles. The composition of the rim corresponds to the B{sub x}(C,Si,Al){sub y} quaternary carbide phase. The reaction of alumina with graphite and the formation of a gaseous aluminum suboxide (Al{sub 2}O) accounts for the transfer of aluminum in the melt and, subsequently in the rim regions. The presence of Al increases the solubility of boron in liquid silicon, but with increasing aluminum content the activity of boron decreases. These features dominate the structural evolution of the rim-core in the presence of aluminum in the melt.

  1. Bone Biopsy

    ... News Physician Resources Professions Site Index A-Z Bone Biopsy Bone biopsy uses a needle and imaging ... the limitations of Bone Biopsy? What is a Bone Biopsy? A bone biopsy is an image-guided ...

  2. Energy Dependence of Synchrotron X-Ray Rims in Tycho's Supernova Remnant

    Tran, Aaron; Williams, Brian J.; Petre, Robert; Ressler, Sean M.; Reynolds, Stephen P.

    2015-10-01

    Several young supernova remnants (SNRs) exhibit thin X-ray bright rims of synchrotron radiation at their forward shocks. Thin rims require strong magnetic field amplification beyond simple shock compression if rim widths are only limited by electron energy losses. But, magnetic field damping behind the shock could produce similarly thin rims with less extreme field amplification. Variation of rim width with energy may thus discriminate between competing influences on rim widths. We measured rim widths around Tycho's SNR in five energy bands using an archival 750 ks Chandra observation. Rims narrow with increasing energy and are well described by either loss-limited or damped scenarios, so X-ray rim width-energy dependence does not uniquely specify a model. But, radio counterparts to thin rims are not loss-limited and better reflect magnetic field structure. Joint radio and X-ray modeling favors magnetic damping in Tycho's SNR with damping lengths ˜1%-5% of remnant radius and magnetic field strengths ˜50-400 μG assuming Bohm diffusion. X-ray rim widths are ˜1% of remnant radius, somewhat smaller than inferred damping lengths. Electron energy losses are important in all models of X-ray rims, suggesting that the distinction between loss-limited and damped models is blurred in soft X-rays. All loss-limited and damping models require magnetic fields ≳20 μG, affirming the necessity of magnetic field amplification beyond simple compression.

  3. Stability of the Taylor--Culick receding rim: surprising observations

    Lhuissier, Henri; Villermaux, Emmanuel

    2008-11-01

    When punctured, a uniform liquid sheet is known, since Taylor and Culick, to recess at a constant speed balancing surface tension and inertia. For planar soap films, this steady solution holds until the initially smooth receding rim is violently destabilized, exhibiting deep indentations from which droplets are ejected. A surprising new three dimensional mechanism explaining this destabilization and resulting wavelength has been evidenced : because of the shear between the still outer medium and the receding liquid, the film flaps through a Kelvin--Helmholtz instability, itself inducing an acceleration perpendicular to the film, which intensifies with the flapping amplitude. To this acceleration is associated a classical Rayleigh--Taylor mechanism, promoting the rim indentations. The same mechanism holds for a punctured round bubble, for which the relevant acceleration is the Culick velocity squared divided by the bubble radius. The bearing of this phenomenon on aerosols formation in Nature will be underlined.

  4. Stability Analysis of Non-Newtonian Rimming Flow

    Fomin, Sergei; Haine, Peter

    2015-01-01

    The rimming flow of a viscoelastic thin film inside a rotating horizontal cylinder is studied theoretically. Attention is given to the onset of non-Newtonian free-surface instability in creeping flow. This non-inertial instability has been observed in experiments, but current theoretical models of Newtonian fluids can neither describe its origin nor explain its onset. This study examines two models of non Newtonian fluids to see if the experimentally observed instability can be predicted analytically. The non-Newtonian viscosity and elastic properties of the fluid are described by the Generalized Newtonian Fluid (GNF) and Second Order Viscoelastic Fluid (SOVF) constitutive models, respectively. With linear stability analysis, it is found that, analogously to the Newtonian fluid, rimming flow of viscous non-Newtonian fluids (modeled by GNF) is neutrally stable. However, the viscoelastic properties of the fluid (modeled by SOVF) are found to contribute to the flow destabilization. The instability is shown to in...

  5. Ultrasonic Resonance Spectroscopy of Composite Rims for Flywheel Rotors

    Harmon, Laura M.; Baaklini, George Y.

    2002-01-01

    Flywheel energy storage devices comprising multilayered composite rotor systems are being studied extensively for utilization in the International Space Station. These composite material systems were investigated with a recently developed ultrasonic resonance spectroscopy technique. The ultrasonic system employs a continuous swept-sine waveform and performs a fast Fourier transform (FFT) on the frequency response spectrum. In addition, the system is capable of equalizing the amount of energy at each frequency. Equalization of the frequency spectrum, along with interpretation of the second FFT, aids in the evaluation of the fundamental frequency. The frequency responses from multilayered material samples, with and without known defects, were analyzed to assess the capabilities and limitations of this nondestructive evaluation technique for material characterization and defect detection. Amplitude and frequency changes were studied from ultrasonic responses of thick composite rings and a multiring composite rim. A composite ring varying in thickness was evaluated to investigate the full thickness resonance. The frequency response characteristics from naturally occurring voids in a composite ring were investigated. Ultrasonic responses were compared from regions with and without machined voids in a composite ring and a multiring composite rim. Finally, ultrasonic responses from the multiring composite rim were compared before and after proof spin testing to 63,000 rpm.

  6. A radiographic investigation of third carpal bone injury in 42 racing thoroughbreds

    A retrospective study of carpal radiographs from 42 racing thoroughbreds with carpal lameness was performed. Radiographs from 50 carpal examinations were available for review. The radiographic findings pertaining to the third carpal bone were described. Fractures and/or sclerosis occurred almost exclusively within the radial fossa. The occurrence of sclerosis without fracture in 20 of the 50 carpal examinations was higher than anticipated, occurring in both the right and left third carpal bone with equal frequency. The right third carpal bone was more frequently fractured and more severely affected than the left. The sclerotic changes seen in the radial fossa of the third carpal bone may be stress-induced, possibly preceding more serious changes in the joint such as cartilage damage or gross fracture. Earlier recognition of sclerosis of the third carpal bone may help prevent more serious changes from occurring

  7. Factors influencing diagnostic yield of CT-guided percutaneous core needle biopsy for bone lesions

    Aim: To evaluate the factors influencing diagnostic yield of computed tomography (CT)-guided percutaneous core needle biopsy (CNB) for bone lesions. Materials and methods: Between September 2005 and July 2011, 162 consecutive CT-guided CNB procedures were performed in 155 patients. The variables analysed were age, sex, lesion location, lesion type, lesion size, specimen size, biopsy needle gauge, and individual radiologist. The factors influencing diagnostic yield of CT-guided percutaneous CNB for bone lesions were determined by multivariate analysis of variables. Results: The diagnostic yield was 81.5%. Diagnostic yield was 89.9% for lytic bone lesions and 48.5% for sclerotic bone lesions (p < 0.001), and 89.2% for lesions ≥3 cm and 73.4% for lesions <3 cm (p = 0.010). The significant factors influencing diagnostic yield of CT-guided percutaneous CNB for bone lesions were lesion type [p < 0.001; odds ratio (OR) for a lytic lesion was approximately 12 times higher than that for a sclerotic lesion; 95% confidence interval (CI): 4.22–34.01], and lesion size (p = 0.012; OR for a lesion size ≥3 cm was about five-times higher than that for a lesion size <3 cm; 95% CI: 1.42–16.71). Conclusion: Lesion type and lesion size are determining factors in diagnostic yield. The higher diagnostic yield is correlated with lytic lesion and lesion size ≥3 cm

  8. A SCUBA survey of bright-rimmed clouds

    Morgan, L. K.; Thompson, M. A.; Urquhart, J. S.; White, G. J.

    2008-01-01

    Context: Bright-rimmed clouds (BRCs) are potential examples of triggered star formation regions, in which photoionisation driven shocks caused by the expansion of HII regions induce protostellar collapse within the clouds. Aims: The main purpose of the paper is to establish the level of star formation occuring within a known set of BRCs. A secondary aim is to determine the extent, if any, to which this star formation has been promulgated by the process of photoionisation triggering. Methods: A primary set of observations is presented obtained with submillimeter SCUBA observations and archival data from near-IR and mid- to far-IR have been explored for relevant observations and incorporated where appropriate. Results: SCUBA observations show a total of 42 dense cores within the heads of 44 observed BRCs drawn from a catalogue of IRAS sources embedded within HII regions, supportive of the scenario proposed by RDI models. The physical properties of these cores indicate star formation across the majority of our sample. This star formation appears to be predominately in the regime of intermediate to high mass and may indicate the formation of clusters. IR observations indicate the association of early star forming sources with our sample. A fundamental difference appears to exist between different morphological types of BRC, which may indicate a different evolutionary pathway toward star formation in the different types of BRC. Conclusions: Bright-rimmed clouds are found to harbour star formation in its early stages. Different evolutionary scenarios are found to exist for different morphological types of BRC. The morphology of a BRC is described as type “A”, moderately curved rims, type “B”, tightly curved rims, and “C”, cometary rims. “B” and “C” morphological types show a clear link between their associated star formation and the strength of the ionisation field within which they are embedded. An analysis of the mass function of potentially induced star-forming regions indicate that radiatively-driven implosion of molecular clouds may contribute significantly toward the intermediate to high-mass stellar mass function. Appendix is only available in electronic form at http://www.aanda.org

  9. Hydrogeology associated to faulting of the Chicxulub Impact Crater rim

    Rebolledo-Vieyra, M.; Hernandez-Terrones, L.; Almazan-Becerril, A.; Valadez-Cruz, F.

    2011-12-01

    The only surface expression of the Chicxulub Impact Crater is a Ring of Cenotes (sinkholes) whose density varies from several cenotes per kilometer, to several kilometers between each cenote. This ring has a radius of approximately 90 km and it is centered at Chicxulub Puerto. It is not known today whether the Ring of Cenotes is the surface expression of the transient cavity as some authors have suggested, or whether it is the outer rim of the impact structure. The center of the ring is approximately coincident with the center of the Chicxulub Impact Crater. Reactivation of K/T rim faults had been associated to the formation of the ring of cenotes. However, none of these models project such faults to the Tertiary sedimentary sequence; therefore we can only infer that the cenotes are associated to these faults. Other hypotheses include "post impact subsidence induced by slumping and viscous relaxation in the rim" and "slumping in the rim of the buried crater, differential thickness in the rocks overlying the crater, or solution collapse within porous impact deposits", others suggest duration of subaerial exposure and weathering as a principal reason both for difference in permeability and cenote density inside and outside the Ring. This is consistent with the evolution of surface features reported. While sedimentation occurred in the basin outlined by the Ring, erosion and karst weathering were taking place outside the Ring. The karst features are associated with gravity gradients, which have been interpreted as corresponding to peripheral faults of the buried crater. We conducted geoelectric tomography perpendicular to the ring of cenotes, where we mapped the karstic features in the area and we interpret the high permeability in this area, to be associated to the faults generated by the differential compaction of the sedimentary sequence within the crater. This fault system generates a secondary porosity with high permeability that allows the circulation of water, which, in turn, will dissolve the carbonates of the roof and hanging walls of the faults. Another group of cenotes, that is not related to the ring of cenotes, is the alignment of >100 km long chains of elongated solution depressions locally known as sabanas along the Holbox fracture zone-Xel-Ha zone; these alignments support the hypothesis of generation of karst features associated to weakness zones in major fractures zones, such as Holbox fracture zone-Xel-Ha zone and the Chicxulub crater rim.

  10. Rim formation and fission gas behaviour: some structure remarks

    In high burn-up LWR nuclear fuel an increase of the Xe-mobility is observed in the rim region according to EPMA. This often coincides with an increase of the local porosity and the grain subdivision of the material in regions around the pores. The restructuring does not always imply disappearance of the prior grain boundaries. This seems to occur in a final step. Micro-XRD studies also show a contraction of the fuel lattice in the rim zone, reflecting mainly the release of accumulated stresses during irradiation, via reordering of defects and defect complexes, including sub-grain formation and displacement of Xe traps. The lattice contraction is not measurable when the fraction of restructured areas is low and the prior grain structure still remains. Nevertheless, in such a case, even the Xe signal by EPMA is observed to decrease, anticipating the displacement of Xe inside the grains, probably towards cavities. However, the quantitative proportion of Xe in matrix and pores can not be given by EPMA. This is confirmed by TEM examinations, showing still plenty of gas bubbles inside restructured grains, in spite of the low Xe signal detected by EPMA. An alternative determination therefore appears necessary. The fission gas release (FGR) behaviour of the rim zone seems then to depend basically on the efficiency of gas retention in its porosity. The closed character of these pores and the low percolation probability derived from the high pore to grain size ratio anticipate a low incidence of open porosity. Also, mechanical tests suggest a low pore interconnection probability by microcracking. However, at very high local burn-ups (>150 GWd/tM), too high porosity values are determined compared to the values derived from immersion density and solid swelling, suggesting the potential existence of open channels. Also, abnormally high porosity values by quantitative metallography might arise from grain pullout during sample preparation. Here, a rough estimation of the release fraction from the rim zone is made, considering the persistence of all prior grain boundaries and the interconnection of all pores near these boundaries in a range of one pore radius. In this mostly improbable case, a maximum release of about 15% is estimated. For a precise FGR characterisation of the rim zone, quantitative determinations of the pore connectivity and of the real ratio: Xe in matrix/Xe in pores still seem to be lacking. (authors)

  11. 18F-FDG PET/CT bone/bone marrow findings in Hodgkin's lymphoma may circumvent the use of bone marrow trephine biopsy at diagnosis staging

    Accurate staging of Hodgkin's lymphoma (HL) is necessary in selecting appropriate treatment. Bone marrow trephine biopsy (BMB) is the standard procedure for depicting bone marrow involvement. BMB is invasive and explores a limited part of the bone marrow. 18F-FDG PET/CT is now widely used for assessing response to therapy in HL and a baseline study is obtained to improve accuracy. The aim of this retrospective analysis was to assess whether routine BMB remains necessary with concomitant 18F-FDG PET/CT. Data from 83 patients (newly diagnosed HL) were reviewed. All patients had received contrast-enhanced CT, BMB and 18F-FDG PET/CT. Results of BMB were not available at the time of 18F-FDG PET/CT imaging. Seven patients had lymphomatous involvement on BMB. Four patients had bone involvement on conventional CT (two with negative BMB). All patients with bone marrow and/or bone lesions at conventional staging were also diagnosed on 18F-FDG PET/CT scan. PET/CT depicted FDG-avid bone/bone marrow foci in nine additional patients. Four of them had only one or two foci, while the other had multiple foci. However, the iliac crest, site of the BMB, was not involved on 18F-FDG PET/CT. Osteolytic/sclerotic lesions matching FDG-avid foci were visible on the CT part of PET/CT in three patients. MRI ordered in three other patients suggested bone marrow involvement. Interim and/or end-therapy 18F-FDG PET/CT documented response of FDG-avid bone/bone marrow foci to chemotherapy in every patient. 18F-FDG PET/CT highly improves sensitivity for diagnosis of bone/bone marrow lesions in HL compared to conventional staging. (orig.)

  12. Microstructural Investigation of a Wark-Lovering Rim on a Vigarano CAI

    Han, J.; Keller, L. P.; Needham, A. W.; Messenger, S.; Simon, J. I.

    2015-01-01

    Wark-Lovering (WL) rims are thin multi-layered mineral sequences that surround many CAIs. These rim layers consist of the primary minerals found in the CAI interiors, but vary in their mineralogy. Several models for their origin have been proposed including condensation, reaction with a nebular gas, evaporation, or combinations of these. However, there still is little consensus on how and when the rims formed. Here, we describe the microstructure and mineralogy of a WL rim on a type B CAI from the Vigarano CV(sub red) chondrite using FIB/TEM to better understand the astrophysical significance of WL rim formation.

  13. Interesting bone scans - unusual findings

    Dobson, M.; Wadhwa, S.S.; Mansberg, R.; Fernandes, V.B. [Wollongong Hospital, Wollongong, NSW (Australia)

    1997-12-01

    A 59-year-old female with carcinoma of the colon and known liver metastatic disease was referred for bone scan to evaluate for bone metastases. Although no bone metastases were found, there was abnormal uptake noted in the liver corresponding to a metastatic calcified lesion. The only other findings were of degenerative disease in the cervical spine, right shoulder and small joints of the hands. A 69-year-old male with carcinoma of the prostate and right side low back pain was referred for bone scan. No focal abnormalities to suggest metastatic disease were identified; findings within the cervical spine, lumber spine and knees were presumed secondary to degenerative disease. Intermittent pain persisted and the patient was referred for a repeat bone scan six months later. Previous scan findings of degenerative disease and no metastatic disease were confirmed; however, closer inspection revealed an enlarged right kidney with significant retention of tracer in the pelvicalyceal system suggesting possible obstruction. A Retrograde pyelogram was performed, and no obvious obstruction demonstrated. As bone scan findings were very suggestive of obstruction, a DTPA scan with lasix was performed showing a dilated right collecting system with no functional obstruction. Given the degree of dilation, it is possible that the patient experiences intermittent PUJ obstruction causing his symptoms. A 33-year-old male with insulin dependent diabetes mellitus and viral arthritis was referred for a bone scan. A three phase revealed increased uptake in the region of the knee and leR proximal tibia. Delayed whole body images revealed multiple focal areas of osteoblastic activity in the leR tibia. Abnormal uptake was also seen in the upper third of the leR femur. The remainder of the skeletal survey was normal. X-ray correlation of the leR tibia and femoral findings was undertaken. Combinating unilateral changes on bone scan and X-ray although very suggestive of sclerotic polyostotic fibrous dysplasia. Three cases with interesting and unusual bone scan findings assisted in further management and treatment of patients

  14. Interesting bone scans - unusual findings

    A 59-year-old female with carcinoma of the colon and known liver metastatic disease was referred for bone scan to evaluate for bone metastases. Although no bone metastases were found, there was abnormal uptake noted in the liver corresponding to a metastatic calcified lesion. The only other findings were of degenerative disease in the cervical spine, right shoulder and small joints of the hands. A 69-year-old male with carcinoma of the prostate and right side low back pain was referred for bone scan. No focal abnormalities to suggest metastatic disease were identified; findings within the cervical spine, lumber spine and knees were presumed secondary to degenerative disease. Intermittent pain persisted and the patient was referred for a repeat bone scan six months later. Previous scan findings of degenerative disease and no metastatic disease were confirmed; however, closer inspection revealed an enlarged right kidney with significant retention of tracer in the pelvicalyceal system suggesting possible obstruction. A Retrograde pyelogram was performed, and no obvious obstruction demonstrated. As bone scan findings were very suggestive of obstruction, a DTPA scan with lasix was performed showing a dilated right collecting system with no functional obstruction. Given the degree of dilation, it is possible that the patient experiences intermittent PUJ obstruction causing his symptoms. A 33-year-old male with insulin dependent diabetes mellitus and viral arthritis was referred for a bone scan. A three phase revealed increased uptake in the region of the knee and leR proximal tibia. Delayed whole body images revealed multiple focal areas of osteoblastic activity in the leR tibia. Abnormal uptake was also seen in the upper third of the leR femur. The remainder of the skeletal survey was normal. X-ray correlation of the leR tibia and femoral findings was undertaken. Combinating unilateral changes on bone scan and X-ray although very suggestive of sclerotic polyostotic fibrous dysplasia. Three cases with interesting and unusual bone scan findings assisted in further management and treatment of patients

  15. Estimation of pore pressure in the rim region of high burnup UO2 fuel

    An attempt has been made to estimate the pore pressure in the rim region of high burnup UO2 fuel as a function of rim burnup using the measured rim width, average porosity and pore density in the rim region. First, a linear relationship is developed based on measured rim burnup and rim width. Second, fraction of fission gas retained in the grain boundary of rim region is estimated. Third, total pores in the rim is calculated from the measured pore density in the rim region. Finally using the assumption that all the pores in the rim have the same size of 1.2μm, pore pressure is calculated from the equation of state for ideal gas. An estimated pore pressure of about 60 to 80 MPa for the rim burnup of 90 GWd/tU appears to be in reasonable agreement with other value given in a literature that pore pressure at 800 K become 90-210 MPa for pellet average burnup of 80 GWd/tU

  16. Auto-Optimization of Dewetting Rates by Rim Instabilities in Slipping Polymer Films

    Reiter, Günter; Sharma, Ashutosh

    2001-10-01

    We investigated the instability of the moving rim in dewetting of slipping polymer films. Small fluctuations of the width of the rim get spontaneously amplified since narrower sections of the rim move faster than wider ones due to frictional forces being proportional to the width of the rim. Instability leads eventually to an autocontrol of the rim width by the continuous formation of droplets with a mean size proportional to the initial film thickness. Surprisingly, the mean dewetting velocity at late stages, averaged over the length of the rim, was found to be constant. Thus, the instability of the rim enabled a more efficient, i.e., faster, ``drying'' of the substrate. Nonslipping films did not show this instability.

  17. The management of helical rim keloids with excision, split thickness skin graft and intralesional triamcinolone acetonide

    Ibrahim Abdul Rasheed

    2014-01-01

    Full Text Available Keloids of the helical rim are disfiguring. A cosmetically acceptable reconstruction is difficult especially in moderate to large sized lesions because the helical rim is a 3-dimensional structure with curved and thin cartilage. We report our experience in the management of moderate (4-10 cm and large (>10 cm helical rim keloids in five patients. Six helical rim keloids were reconstructed. There were four moderate (4-10 cm and two large (>10 cm helical rim keloids. Four were on the right helix and two on the left helix. One patient had bilateral helical rim keloids. The follow-up period ranged from 6 months to 4 years. No secondary surgical revision was required to improve the contour of the reconstructed helical rim. The aesthetic results were satisfactory in all the patients.

  18. Radiography, Bone Scan, and F-18 FDG PET/CT Imaging Findings in a Patient with Paget's Disease

    Background A 52-year-old female patient sought evaluation at our hospital for an incidental abnormal finding on an abdominal radiograph. The initial radiograph showed irregular sclerotic changes involving the right pelvic bone. At the same time, bone scintigraphy showed intense hot uptake in the right iliac and pubic bones. CT images showed characteristic thickening of the pelvic brim, suggesting the mixed phase of Paget's disease. The level of alkaline phosphatase (ALP) was 266 IU/I. 18F-FDG PET/CT images also showed diffusely increased 18F-FDG uptake in the right pelvic bone. However, the findings of 18F-FDG PET/CT were less notable than those of bone scintigraphy. We report the imaging findings of a patient with Paget's disease evaluated by radiography, bone scintigraphy, and 18F-FDG PET/CT.

  19. Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis

    V Silva

    2007-01-01

    Full Text Available Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Quinck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones.A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, diagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

  20. High mobility of landslides on the Mercury crater rims

    Fukuoka, H.; Kadota, N.; Kiritoshi, I.; Sugiyama, H.; Uragami, H.

    2013-12-01

    The NASA's MESSENGER mercury spacecraft was launched by NASA in 2004, and orbital insertion was successfully completed in 2011. Among its scientific instruments, the Mercury Dual Imaging System (MDIS) and the Mercury Laser Altimeter (MLA) are used to extract the mercury terrain topography. This mission revealed various features of the mercury topography with horizontal resolution of 1 km. Up to July 2013, elevation of the north hemisphere terrain had been released on the net (Quickmap: http://messenger-act.actgate.com/msgr_public_released/react_quickmap.html). As reported by previous studies on landslides found on the lunar crater rims (Fukuoka et al., 2011), they showed extremely small H/V = tan (apparent friction) of the movement, even though almost no groundwater could have been expected ever. Authors examined the crater rims in the northern hemisphere of latitude higher than 65 degrees, because the precision of the altitude is higher in the polar and equatorial regions. We found as many similar landslides along the crater rims. Then, in order to compare the mobility of landslides with lunar ones, we have examined the apparent friction (H/T). In most cases, the H/T values of those landslides are between 0.1 and 0.2, like long-runout landslides on the Moon, Mars and Earth. If the rocks on the mercury show the similar friction as rocks on the earth, those values should be higher than 0.5. Possible mechanism of the small H/L could be cumulated shear displacement induced by repeated quakes by meteor impact over billions of years and / or exotic mechanism including tectonic function.

  1. Investigation about crack propagation paths in thin rim gears

    F. Curà

    2014-10-01

    Full Text Available Crack propagation in gears is a problem related not only to the life of the components, but also to the concept of failsafe design. Fail safe design means to design a component in order that, if a failure occurs, this may cause a “safe failure”. This aspect is very important above all in aerospace industry. As a matter of fact, in aerospace application, the need of reducing weight brings to produce gears with very thick rim and web. Considering thin rim gears, when a crack is nucleated near the tooth root, it may propagate through the tooth (causing the loss of the entire tooth or a portion of it or the propagation may follow a path across the wheel diameter (causing the projection of big parts of the gear that may break the gearbox and may cause serious damage to the aircraft. The first failure mode is define as “failsafe failure” and the second one as “catastrophic failure” and of course has to be avoided. Designers need to have robust design criteria in order to predict crack propagation paths and to avoid catastrophic failures. In literature, few works are present concerning this topic, in particular related to the effect of geometrical parameters that may affect the crack propagation. In this work a numerical analysis about crack propagation in gears with respect to the backup ratio (ratio between tooth height and rim thickness, initial crack position and shape has been done by means of the Extended FEM (XFEM technique, realizing 3D models. XFEM 3D is a relatively new technique consisting in enriching traditional finite elements with more complex shape functions; in this way it is possible to propagate crack also between mesh nodes and to have mesh independent results. Aim of this paper is to highlight the crack propagation path in order to give to designers an high confident design criterion, related to the gear geometry. In particular, the effect of both rim thickness and orientation of the initial crack have been considered in order to enrich the literature knowledge. Numerical results obtained in this work have been compared with those found in the literature, showing a very good correlation.

  2. A STUDY OF HAEMOGLOBIN PATTERNS AMONG THE STUDENTS OF RIMS

    Urmila

    2015-11-01

    Full Text Available Haemoglobinopathies are a major health problem worldwide. Because of the high prevalence of these disorders in India and especially in North–East, we undertook this limited student based study as RIMS comprised students from the seven North-East states of Arunachal Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Sikkim and Tripura. AIMS: To study the prevalence of haemoglobin variants among the North-East students of RIMS and to find out any abnormal haemoglobin pattern pertaining to a particular community. MATERIAL AND METHODS: The present study was carried out in the Department of Pathology, RIMS. From Sept. 2002 to Dec. 2004, our study included 100 student volunteers taking a minimum of ten from each of the seven states. History of presenting complaints, personal, family and past illness were taken. Physical examination was done with special emphasis on appearance, presence of pallor, jaundice and hepatosplenomegaly etc. Blood samples were collected in 2 EDTA vials, one was used for CBC and another for preparation of hemolysate. CBC was done for all cases by electronic cell counter supported by manual hemocytometry, peripheral blood examination and reticulocyte count. All the cases were routinely screened for haemoglobin type using standard alkaline cellulose acetate electrophoresis with Tris-Ethylene Diamine Tetra Acetic Acid (EDTA borate buffer. Fetal Hb. estimation, sickling test, serum bilirubin estimation were also done in relevant cases. RESULTS: Out of the 100 student volunteers studied, 98 cases showed HbA pattern in 46 males and 52 females while HbE was seen in 2 cases, 1 male and a female. The prevalence of HbE was 2% in our study, which belonged to the ethnic group of Garo of Meghalaya. Both case had mild anemia with microcytosis and normal reticulocyte count. Peripheral smear showed anisopoikilocytosis and target cells. RBC count, MCH values were within normal range. CONCLUSION: Our study showed that HbA was the predominant haemoglobin type amongst the North-East students of RIMS. HbE was also prevalent amongst these students and common among the mongoloid group of Garo with an incidence of 2%. As this study is limited student volunteer based, it cannot represent any community/population. It emphasises the need for further studies with a larger sample involving many communities of different ethnic groups to support the above findings before drawing a conclusion.

  3. Energy Dependence of Synchrotron X-Ray Rims in Tycho's Supernova Remnant

    Tran, Aaron; Petre, Robert; Ressler, Sean M; Reynolds, Stephen P

    2015-01-01

    Several young supernova remnants exhibit thin X-ray bright rims of synchrotron radiation at their forward shocks. Thin rims require strong magnetic field amplification beyond simple shock compression if rim widths are only limited by electron energy losses. But, magnetic field damping behind the shock could produce similarly thin rims with less extreme field amplification. Variation of rim width with energy may thus discriminate between competing influences on rim widths. We measured rim widths around Tycho's supernova remnant in 5 energy bands using an archival 750 ks Chandra observation. Rims narrow with increasing energy and are well described by either loss-limited or damped scenarios, so X-ray rim width-energy dependence does not uniquely specify a model. But, radio counterparts to thin rims are not loss-limited and better reflect magnetic field structure. Joint radio and X-ray modeling favors magnetic damping in Tycho's SNR with damping lengths ~1--5% of remnant radius and magnetic field strengths ~50--...

  4. Externally Influenced Evolution in Bright-Rimmed Cloud SFO 14

    Figura, Charles C.; Morgan, L.; Urquhart, J.

    2007-12-01

    Bright-Rimmed Clouds (BRCs) are situated on the periphery of HII regions and are suspected sites of triggered star formation via the the mechanism of Radiative Driven Implosion (RDI). The focus of this study is to investigate the conditions within one BRC and determine the effects of the ionizing radiation on star formation and cloud evolution. We present multi-wavelength observations of the BRC SFO14 (IC 1848A) in NH3(1,1) and (2,2), CCS(J=2-1), and CO(J=3-2). These observations are complemented with archival Spitzer data. The NH3(1,1) emission maps two cores within SFO14, the larger of which is coincident with star forming region AFGL 4029 and a SCUBA submillimetre core previously reported by Morgan et al. (accepted). This extended emission around the core shows strong evidence of erosion by ionizing radiation (including elongation radially away from ionizing source BD +59 578). The velocity distribution of the elongation suggests that this core is located to the foreground of BD +59 578. NH3 inversion line measurements indicate rotation temperatures between 15K and 30K for the cloud, with higher rotation temperatures at the windward edge of the primary core nearest the cloud rim.

  5. Triggered star formation in bright-rimmed clouds

    Morgan, L. K.; Urquhart, J. S.; Thompson, M. A.; White, G. J.

    A sample of optically Bright-Rimmed Clouds (BRC) at the edge of HII regions has been observed at multiple wavelengths in order to investigate the possibility that star-formation is present. Such activity may be related to photoionisation induced shocks caused by the massive stars powering the HII regions. The sample has been observed at radio, infrared and submillimetre wavelengths. Both molecular line studies and continuum observations have been made of the larger cloud structures and embedded sources within. Radio and infrared continuum observations show the presence of ionised boundary layers coincident with the optically bright rims. These are responsible for the propagation of shocks into the clouds interiors, possibly triggering the collapse of cores into protostars. Molecular line studies and submillimetre continuum observations show the presence of centrally condensed cores within the clouds, these cores have high densities and have submillimetre luminosities indicative of class 0 protostars. The total luminosities of the embedded sources reveal a set of forming intermediate to high-mass stars. The identification of these regions as star-forming has important consequences for studies of triggered star-formation, not only does the high incidence of star formation in BRC suggest a high efficiency for Galactic triggered star-formation but the masses of the sources suggest a preferred process for the formation itself.

  6. Dam and spillway construction to remediate a failed reservoir rim

    Kostaschuk, R.; Grover, P.; Wanner, C. [AMEC Earth and Environmental Ltd., Calgary, AB (Canada); Lockhart, S. [Priddis Greens Golf and Country Club, Priddis, AB (Canada)

    2009-07-01

    Priddis Greens Golf and Country Club (PGGCC) is located in southern Alberta, about 25 kilometres southwest of Calgary. Lake Loon reservoir supplies water for irrigation of the 36-hole golf course and also supplies water to the water treatment plant that provides potable water to the golf course and the housing development. An earthen spillway channel on the reservoir rim failed by erosion at the PGGCC during an extreme flood event in June 2005. The failure resulted in loss of the reservoir for the water supply system servicing the golf course and its housing cooperative. Design and reconstruction of the reservoir rim were undertaken and a new concrete spillway structure was built. This paper provided background information on the June 2005 failure and provided an overview of the design concept for reservoir restoration. The Alberta Environment permitting process was also outlined. Hydrology, flood management and spillway design were explained in detail. A geotechnical design of earthworks was also provided. The paper concluded with a discussion of an emergency preparedness and response plan and operation, maintenance and surveillance manual that were developed for the project. 2 refs., 20 figs.

  7. Optimization of Hydride Rim Formation in Unirradiated Zr 4 Cladding

    Shimskey, Rick W.; Hanson, Brady D.; MacFarlan, Paul J.

    2013-09-30

    The purpose of this work is to build on the results reported in the M2 milestone M2FT 13PN0805051, document number FCRD-USED-2013-000151 (Hanson, 2013). In that work, it was demonstrated that unirradiated samples of zircaloy-4 cladding could be pre-hydrided at temperatures below 400°C in pure hydrogen gas and that the growth of hydrides on the surface could be controlled by changing the surface condition of the samples and form a desired hydride rim on the outside diameter of the cladding. The work performed at Pacific Northwest National Laboratory since the issuing of the M2 milestone has focused its efforts to optimize the formation of a hydride rim on available zircaloy-4 cladding samples by controlling temperature variation and gas flow control during pre-hydriding treatments. Surface conditioning of the outside surface was also examined as a variable. The results of test indicate that much of the variability in the hydride thickness is due to temperature variation occurring in the furnaces as well as how hydrogen gas flows across the sample surface. Efforts to examine other alloys, gas concentrations, and different surface conditioning plan to be pursed in the next FY as more cladding samples become available

  8. The importance of rim removal in deep lateral orbital wall decompression

    Kakizaki H

    2011-06-01

    Full Text Available Hirohiko Kakizaki1, Yasuhiro Takahashi1, Akihiro Ichinose2, Masayoshi Iwaki1, Dinesh Selva3, Igal Leibovitch41Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi, Japan; 2Department of Plastic Surgery, Kobe University, Kobe, Hyogo, Japan; 3South Australian Institute of Ophthalmology and Discipline of Ophthalmology and Visual Sciences, University of Adelaide, South Australia, Australia; 4Division of Oculoplastic and Orbital Surgery, Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, IsraelPurpose: To evaluate the surgical outcome of deep lateral orbital decompression with or without rim removal.Design: Retrospective case series.Methods: Thirty-two patients (47 orbits with Graves’ orbitopathy who underwent simple deep lateral decompression or balanced lateral plus medial decompression. Of the 14 patients (24 orbits who underwent simple deep lateral decompression, 8 (13 orbits had temporary rim removal and in 6 (11 orbits the rim was left intact. Of the 18 patients (23 orbits who underwent a balanced decompression, 7 (9 orbits had temporary rim removal and in 11 (14 orbits the rim was left intact. The amount of postoperative reduction in proptosis was compared among these four groups.Results: The average reduction in proptosis in the simple deep lateral decompression group was 5.73 mm (range: 4.0–8.0 mm in the rim removal group and 4.09 mm (range: 2.5–6.0 mm in the intact rim group (P = 0.005. The average reduction in proptosis in the balanced decompression group was 6.39 mm (range: 5.0–8.5 mm in the rim removal group and 5.07 mm (range: 3.0–8.0 mm in the intact rim group (P = 0.039. There was no statistically significant difference in proptosis reduction between the simple deep lateral decompression with rim removal group and the balanced decompression with an intact rim group (P = 0.220.Conclusion: The rim removal approach allows a more effective decompression than the intact rim approach. Simple deep lateral decompression with rim removal approach has a similar effect to balanced decompression through an intact rim.Keywords: deep lateral decompression, balanced decompression, rim removal, intact rim, Graves’ orbitopathy, proptosis

  9. Influence of deformation on dolomite rim growth kinetics

    Helpa, Vanessa; Rybacki, Erik; Grafulha Morales, Luiz Fernando; Dresen, Georg

    2015-04-01

    Using a gas-deformation apparatus stacks of oriented calcite (CaCO3) and magnesite (MgCO3) single crystals were deformed at T = 750° C and P = 400 MPa to examine the influence of stress and strain on magnesio-calcite and dolomite (CaMg[CO3]2) growth kinetics. Triaxial compression and torsion tests performed at constant stresses between 7 and 38 MPa and test durations between 4 and 171 hours resulted in bulk strains of 0.03-0.2 and maximum shear strains of 0.8-5.6, respectively. The reaction rims consist of fine-grained (2-7 μm) dolomite with palisade-shaped grains growing into magnesite reactants and equiaxed granular dolomite grains next to calcite. In between dolomite and pure calcite, magnesio-calcite grains evolved with an average grain size of 20-40 μm. Grain boundaries tend to be straighter at high bulk strains and equilibrium angles at grain triple junctions are common within the magnesio-calcite layer. Transmission electron microscopy shows almost dislocation free palisades and increasing dislocation density within granular dolomite towards the magnesio-calcite boundary. Within magnesio-calcite grains, dislocations are concentrated at grain boundaries. Variation of time at fixed stress (˜17 MPa) yields a parabolic time dependence of dolomite rim width, indicating diffusion-controlled growth, similar to isostatic rim growth behavior. In contrast, the magnesio-calcite layer growth is enhanced compared to isostatic conditions. Triaxial compression at given time shows no significant change of dolomite rim thickness (11±2 μm) and width of magnesio-calcite layers (33±5 μm) with increasing stress. In torsion experiments, reaction layer thickness and grain size decrease from the center (low stress/strain) to the edge (high strain/stress) of samples. Chemical analysis shows nearly stoichiometric composition of dolomite palisades, but enhanced Ca content within granular grains, indicating local disequilibrium with magnesio-calcite, in particular for twisted samples. The shift from local equilibrium is ˜3 mol% in triaxial compression and ˜7 mol% in torsion. Electron backscatter diffraction analysis reveals a crystallographic preferred orientation (CPO) within the reaction layers with [0001] axes parallel to the compression/rotation axis and poles of {2-1-10} and {10-10} prismatic planes parallel to the reaction interface. Compared to isostatic annealing, the CPO is more pronounced and the amount of low-angle grain boundaries is increased. At the imposed experimental conditions, most of the bulk deformation is accommodated by calcite single, which is stronger than magnesite. Application of flow laws for magnesio-calcite and dolomite suggest that the fine-grained reaction products should deform by grain boundary diffusion creep, resulting in lower flow strength than the single crystal reactants. However, microstructural observations indicate that deformation of granular dolomite and magnesio-calcite is at least partially assisted by dislocation creep, which would result in an almost similar strength to calcite. Therefore, flattening of the reaction layers during triaxial compression may be counterbalanced by enhanced reaction rates, resulting in almost constant layer thickness, independent of the applied stress. For simple shear, the reduced reaction kinetics in the high stress/strain region of twisted samples may be related to increased nucleation rates, resulting in a lower grain size and rim thickness.

  10. Signaling Events of the Rim101 Pathway Occur at the Plasma Membrane in a Ubiquitination-Dependent Manner

    Obara, Keisuke; Kihara, Akio

    2014-01-01

    In yeast, external alkalization and alteration in plasma membrane lipid asymmetry are sensed by the Rim101 pathway. It is currently under debate whether the signal elicited by external alkalization is transduced to downstream molecules at the plasma membrane or via endocytosis of the Rim21 sensor protein at the late endosome. We found that the downstream molecules, including arrestin-related protein Rim8, calpain-like protein Rim13, and scaffold protein Rim20, accumulated at the plasma membra...

  11. Analysis of the energy capacity of rim-spoke composite flywheels

    The rim-spoke flywheel consisting of a rim, connected to the hub by spokes encompassing the rim periphery, is one of the most promising types of energy accumulators. For the rational design of rim-spoke flywheels, the authors investigate the dependence of their mass energy capacity and their volume energy capacity; the limit speed on the geometric parameters of the flywheel and the properties of the composites used in making the rim and the spokes are also examined. It is shown through various programs, worked out for analyzing the energy capacity of rim-spoke flywheels, that they can substantially facilitate the designing of such flywheels according to specified requirements that their operational characteristics have to meet

  12. Non-destructive examination technique for steam turbine rotor disk rim cracking

    Turbine disk rim cracking in thermal and nuclear power plants has been a major reliability issue in recent years. This problem which includes both circumferential and radial direction cracking on the hidden face of rim fixation behind the blade hook has become very important in periodic non-destructive examination. To detect these defects, the UT inspection techniques using a conventional single angle probe and a phased array probe without removing blades from wheel rim are developed. This paper summarizes and discusses non-destructive examination methods for turbine rim cracking using phased array technique and other technique and these results. (author)

  13. EFFECT OF RIM THICKNESS ON THE ROOT STRESSES OF SPUR GEAR TOOTH

    Durmuş GÜNAY

    1997-01-01

    Full Text Available In this study, root stresses of spur gear tooth are analysed as plane stress problem by the finite element method (FEM. The effects of rim thickness of spur gear on the root stresses is investigated. The computer program which produces a profile of the gear tooth for obtaining mesh region presenting the problem is prepared. In order to examine the effect of the rim thickness on the root stresses, the stress analysis is made on single tooth models varying the rim thickness in steps. On the basis of these investigations a suitable rim thickness of gear model for stress analysis by FEM is proposed.

  14. RIM101-Dependent and -Independent Pathways Govern pH Responses in Candida albicans

    Davis, Dana; Wilson, R. Bryce; Mitchell, Aaron P.

    2000-01-01

    Growth and differentiation of Candida albicans over a broad pH range underlie its ability to infect an array of tissues in susceptible hosts. We identified C. albicans RIM101, RIM20, and RIM8 based on their homology to components of the one known fungal pH response pathway. PCR product-disruption mutations in each gene cause defects in three responses to alkaline pH: filamentation, induction of PRA1 and PHR1, and repression of PHR2. We find that RIM101 itself is an alkaline-induced gene that ...

  15. Catecholamines and related o-diphenols in cockroach hemolymph and cuticle during sclerotization and melanization: comparative studies on the order Dictyoptera.

    Czapla, T H; Hopkins, T L; Kramer, K J

    1990-01-01

    Catecholamines and related o-diphenols extracted from the cuticle and hemolymph of adult cockroaches during sclerotization and pigmentation of the cuticle were analyzed by reverse phase HPLC with electrochemical detection. At ecdysis, dopamine (DA) o-conjugates predominated in the hemolymph of Periplaneta americana, P. australasiae, P. fuliginosa, P. brunnea, and Blatta orientalis (Blattidae); Blattella germanica (Blattellidae); and Gromphadorhina portentosa and Blaberus craniifer (Blaberidae). N-Acetyldopamine (NADA) conjugates were second in abundance in these species, but were major in the hemolymph of the other blaberoid species, Leucophaea maderae and Nauphoeta cinerea. After ecdysis NADA became the major hemolymph catecholamine in all species as DA decreased rapidly. N-beta-Alanyldopamine (NBAD) concentrations in the hemolymph remained low in all species, although NBAD and its metabolite, N-beta-alanylnorepinephrine (NBANE), were generally the major catecholamines in tanning cuticle. Catechol (1,2-dihydroxybenzene) occurred mainly as a conjugate(s) at high levels in the hemolymph of nymphs and adults of all blattid species. Only trace amounts were detected in B. germanica and Cryptocercus punctulatus (Cryptocercidae), and none was found in any of the blaberoid species. High concentrations of NBANE and NBAD accumulated in tanning cuticle of B. germanica, G. portentosa, and all blattid species, whereas NADA and DA predominated in cuticle from the other blaberoid species, particularly L. maderae and N. cinerea. However, cockroaches as a group appear to utilize both the N-acetyl and N-beta-alanyl catecholamines for stabilization of the exoskeleton. The Blattidae differed most from the other families in having considerably higher concentrations of catecholamines in hemolymph and cuticle, as well as the large amounts of catechol conjugates in the hemolymph. PMID:2391402

  16. The status of water and sanitation among Pacific Rim nations.

    Arnold, Robert G; Heyworthz, Jane; Sáez, A Eduardo; Rodriguez, Clemencia; Weinstein, Phil; Ling, Bo; Memon, Saima

    2011-01-01

    Analysis of relationships among national wealth, access to improved water supply and sanitation facilities, and population health indices suggests that the adequacy of water resources at the national level is a poor predictor of economic development--namely, that low water stress is neither necessary nor sufficient for economic development at the present state of water stress among Pacific Rim nations. Although nations differ dramatically in terms of priority provided to improved water and sanitation, there is some level of wealth (per capita GNP) at which all nations promote the development of essential environmental services. Among the Pacific Rim countries for which there are data, no nation with a per capita GNP > US$18,000 per year has failed to provide near universal access to improved water supply and sanitation. Below US$18,000/person-year, however, there are decided differences in the provision of sanitary services (improved water supply and sanitation) among nations with similar economic success. There is a fairly strong relationship between child mortality/life expectancy and access to improved sanitation, as expected from the experiences of developed nations. Here no attempt is made to produce causal relationships among these data. Failure to meet Millennium Development Goals for the extension of improved sanitation is frequently evident in nations with large rural populations. Under those circumstances, capital intensive water and sanitation facilities are infeasible, and process selection for water/wastewater treatment requires an adaptation to local conditions, the use of appropriate materials, etc., constraints that are mostly absent in the developed world. Exceptions to these general ideas exist in water-stressed parts of developed countries, where water supplies are frequently augmented by water harvesting, water reclamation/reuse, and the desalination of brackish water resources. Each of these processes involves public acceptance of water resources that are at least initially of inferior quality. Despite predictions of looming increases in water stress throughout the world, adaptation and resourcefulness generally allow us to meet water demand while pursuing rational economic development, even in the most water-stressed areas of the Pacific Rim. PMID:21714378

  17. Grain-rimming kaolinite in Permian Rotliegend reservoir rocks

    Waldmann, Svenja; Gaupp, Reinhard

    2016-04-01

    Upper Rotliegend sediments of Permian age from the northeast Netherlands show moderate to good reservoir qualities. The predominant control is by the presence of authigenic grain-rimming kaolinite, which has a negative, but in some parts also a positive, effect on reservoir quality. To better understand the formation and distribution of grain-rimming kaolinite, reservoir rocks were studied in terms of composition and diagenetic processes. Petrographic evidence, summarized as a paragenetic sequence, is integrated with geochemical modeling results to identify early mesodiagenetic water-rock interactions under the participation of gases, i.e., CO2 and H2S, released from underlying Carboniferous source rocks. The sediments investigated were deposited at varying distance from the southern flank of the Southern Permian Basin. Sediments near the basin margin are mainly attributed to a fluvial environment and comprise medium to coarse-grained sandstones and conglomerates. There, vermicular kaolinite occurs with a lath-like structure. Distal to the basin margin, mainly in sandstones intercalated with fine-grained playa sediments, comparatively high amounts of grain-rimming kaolinite occur. There, the presence of this mineral has a significant influence on the rock properties and the reservoir quality. Geochemical modeling suggests that the formation of such kaolinites cannot be explained exclusively by in situ feldspar dissolution. The modeling results support evidence that kaolinite can be formed from precursor clay minerals under the presence of CO2-rich formation waters. Such clay minerals could be corrensite, smectite-chlorite mixed-layer minerals, or chlorite that is potentially present in Rotliegend sediments during early diagenesis. Furthermore, the geochemical modeling can reflect several mineral reactions that were identified from petrographic analysis such as the formation of illite and kaolinite at the expense of feldspar dissolution and consequent silica precipitation. Under the presence of sulfate (SO42 -), partial hematite dissolution and the reduction of Fe3 + to Fe2 + occur, where the latter is further incorporated in Fe-Mg-rich carbonates. The sulfate is bonded in anhydrite. The results of this study are relevant for reservoir quality predictions in kaolinite-dominated systems, as well as for CO2 storage projects and the prediction of long-term fluid-rock interactions under the participation of carbon dioxide and/or other gases.

  18. Unusual Radar Backscatter along the Northern Rim of Imbrium Basin

    Thompson, Thomas W.; Campbell, Bruce A.; Ghent, Rebecca R.; Hawke, B. Ray; Leverington, David W.

    2006-01-01

    A viewgraph presentation of the unusual radar backscatter properties along the Northern Rim of Imbrium Basin is shown. The contents include: 1) Visual and Infrared Observations of Moon; 2) Radar Observations of Moon; 3) Lunar Orbiter Photographs Geologic Setting; 4) 70-cm Radar Data; 5) .70-cm Radar Dark Halo Craters; 6) 3.8-cm Radar Data; 7) 7.5-m Radar Data; 8) 70cm, 3.8 cm and 7.5-m Radar Data; 9) Optical and Infrared Data; 10) Plato Rilles; 11) Isopachs of Crater Ejecta; 12) Plato-like Craters; 13) Observation Summary; 14) Interpretation Matrix; 15) Dark Halo Diameters vs. Crater Size; and 16) Radar Geologic Column.

  19. Radiation hydrodynamical models of the inner rim in protoplanetary disks

    Flock, M; Turner, N J; Benisty, M

    2016-01-01

    Many stars host planets orbiting within a few astronomical units (AU). The occurrence rate and distributions of masses and orbits vary greatly with the host stars mass. These close planets origins are a mystery that motivates investigating protoplanetary disks central regions. A key factor governing the conditions near the star is the silicate sublimation front, which largely determines where the starlight is absorbed, and which is often called the inner rim. We present the first radiation hydrodynamical modeling of the sublimation front in the disks around the young intermediate-mass stars called Herbig Ae stars. The models are axisymmetric, and include starlight heating, silicate grains sublimating and condensing to equilibrium at the local, time-dependent temperature and density, and accretion stresses parametrizing the results of MHD magneto-rotational turbulence models. The results compare well with radiation hydrostatic solutions, and prove to be dynamically stable. Passing the model disks into Monte Ca...

  20. Mass Movement on Vesta at Steep Scarps and Crater Rims

    Krohn, K.; Jaumann, R.; Otto, K.; Hoogenboom, T.; Wagner, R.; Buczkowski, D. L.; Garry, B.; Williams, D. A.; Yingst, R. A.; Scully, J.; De Sanctis, M. C.; Kneissl, T.; Schmedemann, N.; Kersten, E.; Stephan, K.; Matz, K.-D.; Pieters, C. M.; Preusker, F.; Roatsch, T.; Schenk, P.; Russell, C. T.; Raymond, C. A.

    2014-01-01

    The Quadrangles Av-11 and Av-12 on Vesta are located at the northern rim of the giant Rheasilvia south polar impact basin. The primary geologic units in Av-11 and Av-12 include material from the Rheasilvia impact basin formation, smooth material and different types of impact crater structures (such as bimodal craters, dark and bright crater ray material and dark ejecta material). Av-11 and Av-12 exhibit almost the full range of mass wasting features observed on Vesta, such as slump blocks, spur-and-gully morphologies and landslides within craters. Processes of collapse, slope instability and seismically triggered events force material to slump down crater walls or scarps and produce landslides or rotational slump blocks. The spur-and-gully morphology that is known to form on Mars is also observed on Vesta; however, on Vesta this morphology formed under dry conditions.

  1. Donor corneoscleral rim contamination by gentamicin-resistant organisms

    Gopinathan Usha

    1994-01-01

    Full Text Available Gentamicin is the most widely used antibiotic in the decontamination of donor cornea for penetrating keratoplasty. However, the incidence of resistance to gentamicin is on the rise. Bacterial isolates from 178 donor corneal rims were studied for gentamicin sensitivity. The overall rate of gentamicin resistance was 63.4%. At 86.2% the Pseudomonas. species had the highest rate of resistance, followed by Streptococci at 84.6%. The high rate of gentamicin resistance encountered by us and others suggest that either addition of a second antibiotic to corneal storage media or replacement of gentamicin by an antibiotic with a broader spectrum of activity may help reduce the risk of endophthalmitis following penetrating keratoplasty

  2. Ciclamato de sódio e rim fetal

    de Arruda José Germano Ferraz; Martins Alex Tadeu; Azoubel Reinaldo

    2003-01-01

    O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O ciclamato e a ciclohexilamina, seu principal metabólito, atravessam a barreira placentária em humanos e desse modo podem ser expostos ao feto. O rim de ratos pode ser afetado por elevadas doses de ciclamato de sódio. Estudos sobre ef...

  3. Meteorite Ablation Rinds as Analogs for the Origin of Rims on Chondrules

    Bunch, T.; Paque, J. M.; Reynolds, R.; Podolak, M.; Prialnik, D.

    1993-07-01

    Conventional wisdom holds that UOC chondrule rims were formed in the nebula by dust accretion. Following the accretion stage, some investigators suggest that these porous rims were subjected to thermal alteration that ranged from sintering to melting [e. g., 1-3]. To understand the evolutionary history of chondrules we need to ask: (1) What nebular mechanism(s) concentrated the dust for rapid accretion? (Addressed in a companion paper at this meeting [4]). (2) What thermal event(s) welded or melted the dust? (3) Is this dust solely responsible for the rim composition, or are some rims composed, in part, of the parent chondrule? Production and/or modification of rims during atmospheric entry onto a parent body is a scenario that is testable by examination of ablation rinds produced on meteorites during entry into Earth's atmosphere. Comparison of ablation rind features with opaque rims on UOC chondrules will indicate whether this is a viable method for the production of chondrule rims. Terrestrial ablation rinds on UOCs and carbonaceous chondrites have been examined both texturally and chemically. Ablation rinds have these distinct characteristics: (1) The bulk composition of the rind is a reflection of the bulk chemistry of the host object, including Na, K, and P, but with the exception of much lower S. (2) Boundaries between unmelted bulk meteorite and rind silicates are physically sharp over distances of microns, similar to boundaries between rims and their chondrules. However, compositional transition zones extend inward from the boundaries for 10s of microns. (3) Melted meteorite matrix in the rind is compositionally similar to unmelted matrix and is texturally and chemically similar to rims. (4) Mineral texture and chemistry at chondrule/rim and meteorite/rind interfaces indicate significant thermal processing has occurred. For example, sulfides show high concentrations of included, more refractory phases at the melt interface with a corresponding loss of S. Overall, the comparison of ablation rinds with rims strongly suggests that opaque rims formed by melting of dusty accretion mantles. This melting event may have continued into the outer margins of host chondrules, or may be restricted to the accreted dust. SEM examination of the boundaries between chondrules and rims indicate that both cases probably occur. The major and minor element composition of opaque rims is similar to "accretionary" rims on objects in CM meteorites [5]. We suggest that both types of rims were formed from the same basic anhydrous dust, although CM rims acquired more O^16-bearing component than UOCs. From here, their evolutionary paths diverged: Opaque rims were thermally processed and CM rims were aqueously altered. Calculations of rim melting due to entry into a transient atmosphere of low scale height [6] indicate that encounter velocities in the range 2-4 km/sec are sufficient to melt the outer parts of chondrules. If the thermal conductivity of porous accretionary rims is as low as that of powdered chondrite [7], gas dynamic deceleration can produce totally or partially melted rims on chondrules without melting the chondrule itself. References: [1] Rubin A. and Wasson J. (1987) GCA, 51, 1923-1937. [2] Podolak et al. (1990) Icarus, 84, 254-260. [3] Bunch T. et al (1991) Meteoritics, 26, 326. [4] Cuzzi J. and Dobrovolskis A. (1993) this meeting. [5] Metzler et al. (1992) GCA, 56, 2873- 2898. [6] Podolak et al. (1993) Icarus, in press. [7] Wechsler A. E. and Glaser P. E. (1965) Icarus, 4, 335.

  4. Epidemiology of trichinellosis in Asia and the Pacific Rim.

    Takahashi, Y; Mingyuan, L; Waikagul, J

    2000-12-01

    The epidemiology of trichinellosis, species of Trichinella present and the food and eating habits of people affected in Asia and the Pacific Rim are reviewed with emphasis on Japan, China and Thailand. Trichinella seems to be prevalent throughout this region although outbreaks of trichinellosis have not been reported in some areas. Major outbreaks of the disease have been reported primarily in China and Thailand. This is the result of three factors: (1) China and Thailand are highly endemic areas for this parasite; (2) the two countries are well-organized and there is a public health system that enables precise reporting of disease outbreaks and (3) culinary habits provide many opportunities to eat undercooked meats. Trichinella found in Asia and the Pacific Rim includes both encapsulated species (Trichinella spiralis, Trichinella britovi, Trichinella nativa) and noncapsulated species (Trichinella pseudospiralis, Trichinella papuae). T. britovi, isolated in Japan, is a different genotype from the European strain. Therefore, the Japanese strain of T. britovi is designated Trichinella T9. Human trichinellosis caused by T. pseudospiralis has occurred in New Zealand and Thailand. Tasmania has had animal cases of T. pseudospiralis infection and animals with T. papuae infection have been found in Papua New Guinea. Economic losses due to Trichinella infection are not negligible in China, where there have been more than 500 outbreaks of human trichinellosis, affecting more than 20,000 people and causing more than 200 deaths. In Thailand, over the past 27 years, 120 outbreaks were reported involving nearly 6700 patients and 97 deaths. Japan has had fewer outbreaks and some sporadic cases have been attributed to imported infection. PMID:11099839

  5. Bone Diseases

    Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly ... childhood and your teens, your body adds new bone faster than it removes old bone. After about ...

  6. Bone Cancer

    Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another ... more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and ...

  7. Radiography, Bone Scan, and F-18 FDG PET/CT Imaging Findings in a Patient with Paget's Disease

    Park, Eun Tae; Kim, Sung Eun [Korea University Guro Hospital, Seoul (Korea, Republic of)

    2010-04-15

    Background A 52-year-old female patient sought evaluation at our hospital for an incidental abnormal finding on an abdominal radiograph. The initial radiograph showed irregular sclerotic changes involving the right pelvic bone. At the same time, bone scintigraphy showed intense hot uptake in the right iliac and pubic bones. CT images showed characteristic thickening of the pelvic brim, suggesting the mixed phase of Paget's disease. The level of alkaline phosphatase (ALP) was 266 IU/I. {sup 18}F-FDG PET/CT images also showed diffusely increased {sup 18}F-FDG uptake in the right pelvic bone. However, the findings of {sup 18}F-FDG PET/CT were less notable than those of bone scintigraphy. We report the imaging findings of a patient with Paget's disease evaluated by radiography, bone scintigraphy, and {sup 18}F-FDG PET/CT.

  8. Osteopoikilosis: A Cause of Elevated Bone Mineral Density on Dual X-Ray Absorptiometry Measurement in a Young Woman: Case Report

    Asylbek Kaparov

    2010-04-01

    Full Text Available Osteopoikilosis (OPK is an asymptomatic, rare bone dysplasia. It causes an increase in bone density. The etiology and pathogenesis is unknown. OPK is generally diagnosed incidentally on plain radiographies which were performed for other locomotor system symptoms. Diagnostic lesions of OPK are typically diffuse, round, symmetrically shaped sclerotic bone areas. Laboratory findings and bone scintigraphy are usually normal. OPK should be considered in the differential diagnosis of osteoblastic bone disorders. OPK is a benign disease and invasive diagnostic procedures as well as aggressive treatment modalities should be avoided. In young individuals who have elevated scores on dual-energy X-Ray absoptiometry measurement, OPK as well as other sclerosing bone disorders would be considered. (From the World of Osteoporosis 2010;16:25-8

  9. A prospective analysis of CT density measurements of bone metastases after treatment with zoledronic acid

    Quattrocchi, Carlo C.; Dell' Aia, Paola; Piciucchi, Sara; Grasso, Rosario F.; Zobel, Bruno B. [Centro Interdisciplinare per la Ricerca Bio-Medica, Department of Radiology, Rome (Italy); Santini, Daniele; Vincenzi, Bruno; Tonini, Giuseppe [University Campus Bio-Medico di Roma, Department of Oncology, Rome (Italy); Leoncini, Emanuele [Statistica Sanitaria, University La Sapienza, Rome (Italy)

    2007-12-15

    The objective was to prospectively determine CT density changes in bone metastases, before and after intravenous zoledronic acid for a maximum period of 12 months. Twenty-three consecutive patients presented with bone metastases and underwent therapy with zoledronic acid from December 2004. All patients underwent CT of the chest, abdomen, and pelvis. Bone density, measured in Hounsfield units (HU), was determined by segmenting lesions in the same anatomical area of the metastasis sites on the axial images of the sequential series of CT examinations. The effects of zoledronic acid were evaluated by calculating absolute and relative increases in bone density. The patients presented with multiple metastases in 65% of the cases. When compared with the baseline, all groups demonstrated a significant increase in bone density, which significantly (p < 0.01) correlated with the number of zoledronic acid administrations. There was increased bone density of at least 100% in 57%, and an increase of at least 50% in 87% of the patients. This increase was significant in both lytic and sclerotic metastases after 3 months of therapy. No significant bone density difference was found in normal-appearing bone. Bone density measured by CT increases at metastatic sites after zoledronic acid treatment, regardless of the type of metastasis, in contrast to apparently normal bone. (orig.)

  10. A prospective analysis of CT density measurements of bone metastases after treatment with zoledronic acid

    The objective was to prospectively determine CT density changes in bone metastases, before and after intravenous zoledronic acid for a maximum period of 12 months. Twenty-three consecutive patients presented with bone metastases and underwent therapy with zoledronic acid from December 2004. All patients underwent CT of the chest, abdomen, and pelvis. Bone density, measured in Hounsfield units (HU), was determined by segmenting lesions in the same anatomical area of the metastasis sites on the axial images of the sequential series of CT examinations. The effects of zoledronic acid were evaluated by calculating absolute and relative increases in bone density. The patients presented with multiple metastases in 65% of the cases. When compared with the baseline, all groups demonstrated a significant increase in bone density, which significantly (p < 0.01) correlated with the number of zoledronic acid administrations. There was increased bone density of at least 100% in 57%, and an increase of at least 50% in 87% of the patients. This increase was significant in both lytic and sclerotic metastases after 3 months of therapy. No significant bone density difference was found in normal-appearing bone. Bone density measured by CT increases at metastatic sites after zoledronic acid treatment, regardless of the type of metastasis, in contrast to apparently normal bone. (orig.)

  11. Low Bone Density

    ... Bone Density Exam/Testing › Low Bone Density Low Bone Density Low bone density is when your bone ... to people with normal bone density. Detecting Low Bone Density A bone density test will determine whether ...

  12. 16 CFR Figure 8 to Part 1512 - Reflectorized Bicycle Wheel Rim Abrasion Test Device

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Reflectorized Bicycle Wheel Rim Abrasion... HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR BICYCLES Pt. 1512, Fig. 8 Figure 8 to Part 1512—Reflectorized Bicycle Wheel Rim Abrasion Test Device EC03OC91.074...

  13. Nonspecificity of the rim sign in the scintigraphic diagnosis of missed testicular torsion

    Vieras, F.; Kuhn, C.R.

    1983-02-01

    Causes of a hyperemic peritesticular rim on dynamic and static scintigrams are reviewed. Of 6 patients exhibiting such a pattern, 3 had missed testicular torsion; the other 3 had tumor, trauma, or inflamation. The authors conclude that a hyperemic peritesticular rim is a nonspecific finding reflecting underlying pathophysiological changes and is not pathognomonic of missed torsion.

  14. Synchrotron X-Ray Rims in Tycho's Supernova Remnant are Energy Dependent

    Tran, Aaron; Williams, Brian J.; Petre, Robert; Ressler, Sean; Reynolds, Stephen P.

    2015-01-01

    Several young supernova remnants exhibit thin X-ray bright rims of synchrotron radiation at their forward shocks. Thin rims have been taken to indicate that shock-accelerated electrons rapidly cool downstream of the shock, requiring strong magnetic field amplification. But, magnetic field damping immediately behind the shock could produce similarly thin rims. Synchrotron loss-limited rim widths should decrease with energy whereas damping limited rims should be relatively energy-independent. To discriminate between models, we measured rim widths around Tycho's supernova remnant in 5 energy bands using an archival 750 ks Chandra observation. Rims narrow with increasing energy, favoring loss-limited radiation over magnetic damping and corroborating similar observations in the remnant of SN 1006. Observed widths are best fit by electron transport models requiring amplified magnetic fields of ~200-1000 µG and particle diffusion coefficients ~1-100x Bohm values, consistent with prior work on Tycho's SNR. Non-negligible diffusion results in some degeneracy between magnetic field strength and diffusion coefficient in setting observed rim widths, but strong magnetic fields are required for all measurements. A different approach may be needed to better constrain diffusion at supernova remnant shocks.

  15. Prostate cancer with lytic bone metastases: 18F-fluorodeoxyglucose positron emission tomography-computed tomography for diagnosis and monitoring response to medical castration therapy

    Lytic bone metastases are rare in prostate cancer. We here present 18 fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography computed tomography (PET-CT) images of a 67-year-old male patient with lytic metastases from prostate cancer. Repeat 18F-FDG PET-CT done 6 months later showed response to medical castration therapy. While the role of 18F-FDG PET-CT for sclerotic bone metastases in prostate cancer remains controversial, it appears to be useful for detection and response assessment of lytic prostate cancer metastases. (author)

  16. Complex chemical zoning in eclogite facies garnet reaction rims: the role of grain boundary diffusion

    Prenzel, J.; Abart, R.; Keller, L.

    2009-03-01

    In metapelites of the Saualpe complex (Eastern Alps) continuous 10 µm to 20 µm wide garnet reaction rims formed along biotite-plagioclase and biotite-perthite interfaces. The pre-existing mineral assemblages are remnants of low pressure high temperature metamorphism of Permian age. The garnet reaction rims grew during the Cretaceous eclogite facies overprint. Reaction rim growth involved transfer of Fe and Mg components from the garnet-biotite interface to the garnet-feldspar interface and transfer of the Ca component in the opposite direction. The garnets show complex, asymmetrical chemical zoning, which reflects the relative contributions of short circuit diffusion along grain boundaries within the polycrystalline garnet reaction rims and volume diffusion through the grain interiors on bulk mass transfer. It is demonstrated by numerical modelling that the spacing of the grain boundaries, i.e. the grain size of the garnet in the reaction rim is a first order control on its internal chemical zoning.

  17. Soft tissue aneurysmal bone cyst

    Wang, X.L.; Gielen, J.L.; Delrue, F.; De Schepper, A.M.A. [Department of Radiology, Universitair Ziekenhuis Antwerpen (University of Antwerp), Wilrijkstraat 10, 2650, Edegem (Belgium); Salgado, R. [Department of Pathology, Universitair Ziekenhuis Antwerpen (University of Antwerp), Wilrijkstraat 10, 2650, Edegem (Belgium)

    2004-08-01

    A soft tissue aneurysmal bone cyst located in the right gluteus medius of a 21-year-old man is reported. On conventional radiography, the lesion demonstrated a spherically trabeculated mass with a calcific rim. On CT scan, it showed a well-organized peripheral calcification resembling a myositis ossificans. On MRI, it presented as a multilocular, cystic lesion with fluid-fluid levels. The lesion had no solid components except for intralesional septa. Although findings on imaging and histology were identical to those described in classical aneurysmal bone cyst, diagnosis was delayed because of lack of knowledge of this entity and its resemblance to the more familiar post-traumatic heterotopic ossification (myositis ossificans). (orig.)

  18. NEAR-IR IMAGING POLARIMETRY TOWARD A BRIGHT-RIMMED CLOUD: MAGNETIC FIELD IN SFO 74

    Kusune, Takayoshi; Sugitani, Koji [Graduate School of Natural Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-8501 (Japan); Miao, Jingqi [Centre for Astrophysics and Planetary Science, School of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NR (United Kingdom); Tamura, Motohide; Kwon, Jungmi [Department of Astronomy, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Sato, Yaeko [National Astronomical Observatory, 2-21-1 Osawa, Mikata, Tokyo 181-8588 (Japan); Watanabe, Makoto [Department of Cosmosciences, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0810 (Japan); Nishiyama, Shogo [Faculty of Education, Miyagi University of Education, Sendai 980-0845 (Japan); Nagayama, Takahiro [Department of Physics, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065 (Japan); Sato, Shuji [Department of Astrophysics, Nagoya University, Chikusa-ku, Nagoya 464-8602 (Japan)

    2015-01-01

    We have made near-infrared (JHK {sub s}) imaging polarimetry of a bright-rimmed cloud (SFO 74). The polarization vector maps clearly show that the magnetic field in the layer just behind the bright rim is running along the rim, quite different from its ambient magnetic field. The direction of the magnetic field just behind the tip rim is almost perpendicular to that of the incident UV radiation, and the magnetic field configuration appears to be symmetric as a whole with respect to the cloud symmetry axis. We estimated the column and number densities in the two regions (just inside and far inside the tip rim) and then derived the magnetic field strength, applying the Chandrasekhar-Fermi method. The estimated magnetic field strength just inside the tip rim, ∼90 μG, is stronger than that far inside, ∼30 μG. This suggests that the magnetic field strength just inside the tip rim is enhanced by the UV-radiation-induced shock. The shock increases the density within the top layer around the tip and thus increases the strength of the magnetic field. The magnetic pressure seems to be comparable to the turbulent one just inside the tip rim, implying a significant contribution of the magnetic field to the total internal pressure. The mass-to-flux ratio was estimated to be close to the critical value just inside the tip rim. We speculate that the flat-topped bright rim of SFO 74 could be formed by the magnetic field effect.

  19. A SCUBA survey of bright-rimmed clouds

    Morgan, L K; Urquhart, J S; White, G J

    2007-01-01

    Context: Bright-rimmed clouds (BRCs) are potential examples of triggered star formation regions, in which photoionisation driven shocks caused by the expansion of HII regions induce protostellar collapse within the clouds. Aims: The main purpose of the paper is to establish the level of star formation occuring within a known set of BRCs. A secondary aim is to determine the extent, if any, to which this star formation has been promulgated by the process of photoionisation triggering. Methods:A primary set of observations is presented obtained with submillimeter SCUBA observations and archival data from near-IR and mid- to far-IR have been explored for relevant observations and incorporated where appropriate. Results:SCUBA observations show a total of 47 dense cores within the heads of 44 observed BRCs drawn from a catalogue of IRAS sources embedded within HII regions, supportive of the scenario proposed by RDI models. The physical properties of these cores indicate star formation across the majority of our sam...

  20. Secondary aneurysmal bone cystic change of the chondroblastoma, mistaken for a primary aneurysmal bone cyst in the patella.

    Chung, Jin Wha; Lee, Hwa Sung

    2014-03-01

    A 29-year-old woman complained of a 3-month history of left knee pain without trauma history. X-ray showed a well-defined osteolytic lesion with a sclerotic margin in the patella and magnetic resonance imaging showed T1-low and T2-high signal intensity with different fluid level. Our impression was an aneurysmal bone cyst. At surgery, the lesion was a blood-filled cystic cavity, surrounded by a gray or brownish tissue. Hemorrhagic soft tissues with recognizable bone fragments were observed. Curettage and autogenous bone graft was done. Microscopically, sheets of tumor cells were intermingled with some areas of eosinophilic chondroid matrix. The tumor cells showed oval-shaped nuclei with moderate eosinophilic cytoplasm. Several multinucleated giant cells and blood filled cystic cavities were observed. The final diagnosis was a chondroblastoma with a secondary aneurysmal bone cyst. At the post-operative 1.5-year follow-up, grafted bones were well incorporated radiographically and there were no recurrent evidence or any other abnormal symptoms. PMID:24639947

  1. Chondrule Rims in Murchison, Cathodoluminescence Evidence for In Situ Formation by Aqueous Alteration

    Sears, D. W. G.; Jie, Lu; Benoit, P. H.

    1992-07-01

    The fine-grained rims on ordinary and carbonaceous chondrite chondrules are often regarded as accretionary, mainly because they are often volatile-rich (King and King, 1981). However, Sears et al. (1991) recently argued that some chondrule rims in CM chondrites may be the result of aqueous alteration. The rims, like many features in primitive chondrites, stand out especially clearly in cathodoluminescence (CL) imagery due to the distinctive bright red CL of their abundant fine-grained forsterite. Chondrules similarly stand out well in CL images. Group A chondrules show the strong red CL of Fe-free olivine, sometimes associated with the bright yellow CL of anorthite- normative mesostases, while group B chondrules containing Fe-rich olivines and quartz-normative mesostases do not produce CL (Sears et al., 1992). Using a CL mosaic, we measured chondrule and rim diameters for every chondrule in a 17x10 mm section of Murchison. 38% of the chondrules were group A, compared with 46% in the Semarkona (LL3.0) and 61% in the Dhajala (H3.8) ordinary chondrites. While both group A and group B chondrules have rims, those on group A chondrules are significantly thicker than those on group B chondrules, the rim-to-diameter ratios being 0.2-0.5 for group A chondrules and 0.1-0.2 for group B chondrules (Fig. 1). There are two reasonable explanations for the relationship between rim thickness and chondrule group. Either (1) the composition of chondrule mainly determines the thickness of the rim, e.g., the rims were produced by the aqueous alteration of the host chondrule, or (2) the two chondrule groups were formed in different environments, say a very dusty locale favoring thick rims versus a less favorable relatively dust-free location. We note that (a) both types of chondrule coexist in the same rock, (b) CL textures at the rim/matrix are sharp while at the rim/chondrule interface they are irregular (see Fig. 7d,e in Sears et al., 1991), (c) all faces on the objects in Murchison have rims of some sort, including the fracture faces of chondrule fragments, (d) the redistribution of volatiles will have accompanied aqueous alteration, and (e) mesostases of calcic plagioclase composition are more susceptible to hydrolysis than the more SiO2-rich glasses. We therefore suggest that the evidence favors the idea that these rims formed by in situ aqueous alteration. We suspect that most of this alteration predated the complex multistage, multienvironment brecciation process (Metzler et al., 1992). We speculate that some of the coarse-grained rims observed in higher petrologic type meteorites (e.g., Rubin, 1984) were produced by metamorphism of these fine- grained rims. King E. A. and King E. A. (1982) Icarus 48, 460-472. Metzler K. Bischoff A. and Stoffler D. (1992) Geochim. Cosmochim. Acta (in press). Rubin A. E. (1984) Coarse-grained chondrule rims in type 3 chondrites. Geochim. Cosmochim. Acta 48, 1779-1789. Sears D. W. G., Batchelor D. J., Lu J., Keck B. D. (1991) Proc. NIPR Symp. Antarct. Meteor., No. 4, 319-343. Sears D. W. G., Lu J., Benoit P. H., DeHart J. M. and Lofgren G. E. (1992) Nature (in press). Figure 1, which in the hard copy appears here, shows chondrule rim thickness to diameter ratio for 70 chondrules in Murchison. "Group A" and "Group B" refers to the compositional chondrule groups (Sears et al., 1992).

  2. The significance of echogenic rim of atypical hepatic hemangioma on ultrasonogram

    To evaluate whether the presence of a peripheral echogenic rim surrounding internal low echogenicity is helpful in the diagnosis of atypical hepatic hemangioma. Within a two-year period, a retrospective review of the sonographic appearances of 24 atypical hemangiomas in 21 patients was performed. Diagnosis was made by dynamic and delayed enhanced CT, MR imaging or clinical follow up for one year, including follow-up sonogram. The sonographic appearances of these hemangiomas were analyzed for pattern and thickness of the echogenic rim, internal echo pattern, shape, and size. Additionally, forty six lesions of hepatoma, metastasis, abscess and intrahepatic cholangiocarcinoma confirmed by pathology within the same period were also evaluated for the presence of echogenic rim. Twenty-three of 24 lesions showed an echogenic rim;these were thick in nine cases, and thin in 14 cases. The thickness of the rim was either uniform(n=10) or eccentric(n=13). The average maximum diameter of atypical hemangioma was 4.4cm(range of diameters, 1.5-12cm). The internal echo pattern was partially or entirely hypoechoic in 15 lesions, homogeneously isoechoic in three, and mixed in six cases. Twenty-one lesions were round, and the shape of three was irregular. The other forty six masses including hepatocellular carcinoma, metastases, cholangiocarcinoma and hepatic abscesses did not show an echogenic rim. The presence of a sonographic echogenic rim in a hepatic mass may help in the diagnosis of hepatic hemangioma

  3. Modelling of thermal conductivity for high burnup UO2 fuel retaining Rim region

    A thermal conductivity correlation has been proposed which can be applied to high burnup fuel by considering both of thermal conductivity with burnup across fuel pellet and additional degradation at pellet rim due to very high porosity. In addition, a correlation has been developed that can estimate the porosity of rim region as a function of rim burnup under the assumptions that all the produced fission gases are retained in the rim porosity and threshold pellet average burnup required for the formation of rim region is 40 MWD/kgU. Rim width is correlated to rim burnup using measured data. For the RISO experimental data obtained at pellet average burnup of 43.5 MWD/kgU for three linear heat generation rates of 30, 35 and 40 kW/m, radial temperature distributions were calculated using the present correlation and compared with the measured ones. This comparison shows that the present correlation gives the best agreement with the measured data when it is combined with the HALDEN's correlation for thermal conductivity considering its degradation with burnup. Another comparison with the HALDEN's measured fuel centerline temperature as a function of burnup at 25 kW/m up to about 44 MWD/kgU also suggests that the present correlation yields the best agreement when it is combined with the HALDEN's thermal conductivity. (author)

  4. Amphibole Reaction Rims in Response to Decompression compared to Heating: An Experimental Approach

    Browne, B. L.; Gardner, J. E.; Larsen, J.

    2003-12-01

    Amphiboles are an important magmatic mineral phase common to a variety of volcanic settings, and are especially sensitive to variations in the water content and temperature of the surrounding induced during magmatic ascent or heating accompanying magma mixing events. As magma rises toward the surface hydrous amphiboles, stable at high water pressures, break down in response to degassing of the surrounding melt. Reaction rims also form around amphiboles that are destabilized when mixing with hotter, more primitive magmas occurs. In this study, we compare the thickness, composition, and rate of formation of amphibole reaction rims during a series of isothermal decompression and isobaric heating experiments using dacite and andesite magmas erupted from Redoubt volcano, Alaska in 1989-1990. The 1989-90 Redoubt dacite pumice consists of magnesio-hornblendes, plagioclase, othropyroxene, and Fe-Ti oxides in a high-silica rhyolite glass. In contrast, 1989-90 Redoubt andesite contains pargasitic amphiboles, orthopyroxene, clinopyroxene, plagioclase, and Fe-Ti oxides in a rhyodacite glass. Our results indicate that the reaction rims formed in response to decompression are distinguishable in thickness, grain size, and type of mineral formed in the rims from those formed in response to heating, regardless of the type of amphibole studied. First, decompression induced rims were thinner (5- 50 um) compared to those developing in response to heating (25- 200 um). Decompression induced rim growth rate ranges from 0.3 to 0.6 um/day compared to heating induced rim growth rate, which ranges from 0.4 to 1.6 um/day. Second, decompression rims were finer-grained (5-15 um diameter crystals) compared to heating reaction rims (5- 35 um diameter crystals). And third, decompression rims are predominantly composed of orthopyroxene and plagioclase, with lesser amounts of Fe-Ti oxides, whereas reaction rims that grew in response to heating experiments were composed almost entirely of clinopyroxene and Fe-Ti oxides, with lesser amounts of orthopyroxene, and plagioclase. Because the results are independent of the type of amphibole studied, the physical characteristics of reaction rims around amphiboles from a given eruption may yield important information about the rates and types of pre-eruptive disequilibrium event that was the cause.

  5. RIM, Munc13, and Rab3A interplay in acrosomal exocytosis

    Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: ► RIM and Munc13 are present in human sperm and localize to the acrosomal region. ► RIM and Munc13 are necessary for acrosomal exocytosis. ► RIM and Munc13 participate before the acrosomal calcium efflux. ► RIM, Munc13 and Rab3A interplay in human sperm acrosomal exocytosis. ► RIM and Rab3A have critical roles in membrane docking.

  6. Analysis of Gear Resistance with Influence of Rim Thickness by Means on Finite Element Method

    Osney Gerardo Pérez Acosta

    2013-06-01

    Full Text Available This paper presents an application of Finite Element Method (FEM for the simulation of contact onloaded teeth of spur gears. Models of FEM to analyzing gear resistance considering rim stresses areused. The behavior of gear crack path on gears with different rim thickness according to FEM modelsdeveloped in this study was compared with the theoretical and practical values reported by Lewicki.The numerical simulations by FEM models fit quite well the experimental results for evaluation of theeffect of rim thickness on gear crack path.

  7. RIM, Munc13, and Rab3A interplay in acrosomal exocytosis

    Bello, Oscar D.; Zanetti, M. Natalia [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Mayorga, Luis S. [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Michaut, Marcela A., E-mail: mmichaut@fcm.uncu.edu.ar [Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Instituto de Ciencias Basicas, Universidad Nacional de Cuyo, Mendoza (5500) (Argentina)

    2012-03-10

    Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: Black-Right-Pointing-Pointer RIM and Munc13 are present in human sperm and localize to the acrosomal region. Black-Right-Pointing-Pointer RIM and Munc13 are necessary for acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Munc13 participate before the acrosomal calcium efflux. Black-Right-Pointing-Pointer RIM, Munc13 and Rab3A interplay in human sperm acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Rab3A have critical roles in membrane docking.

  8. Varied Mechanisms for Star Formation in Bright-Rimmed Clouds

    Morgan, Larry; Urquhart, J.; Thompson, M.; White, G.; Figura, C.

    2007-12-01

    Bright-rimmed clouds (BRCs) are potential examples of triggered star-formation regions, in which photoionisation driven shocks caused by the expansion of HII regions induce protostellar collapse within the clouds. A sample of optically bright BRCs at the edge of HII regions has been observed at multiple wavelengths in order to investigate the possibility that star-formation is present. Such activity may be related to photoionisation induced shocks caused by the massive stars powering the HII regions. The sample has been observed at radio, infrared and submillimetre wavelengths, these observations reveal dense cores present within the heads of 44 observed BRCs drawn from a catalogue of IRAS sources embedded within HII regions, supportive of the scenario proposed by radiatively driven implosion (RDI) models. The physical properties of these cores indicate the presence of star formation across the majority of our sample. This star-formation appears to be predominately in the regime of intermediate to high mass and may indicate the formation of clusters. IR observations indicate the association of early star forming sources with the sample. A fundamental difference appears to exist between different morphological types of BRC. Morphological variations in BRCs have previously been attributed to an evolutionary scenario of RDI. However, the physical properties of cores found within different types of BRC indicate that the strength of the ambient ionisation field is highly correlated with the attributes of certain cores, and not with others. The suggestion is that different morphological types of BRC have followed different evolutionary pathways, this is supported by the mass distributions of cores associated with the different morphologies.

  9. Out of the Blue: The Pacific Rim as a Region

    Arturo Santa-Cruz

    2005-08-01

    Full Text Available In 1993, in advance of what was to be the first Asia Pacific Economic Cooperation (APEC leader’s summit, US president Bill Clinton gave a lecture at Waseda University in Japan. In his speech, Clinton called for the creation of a “community of the Pacific.” The idea of a Pacific community is neither Clinton’s nor the Democratic Party’s invention, however. In the previous decade Ronald Reagan had already used it, going even beyond later conceptualizations, by referring to the 21st century as the Pacific’s century. But Reagan's prophecy concerning the Great Ocean was not new back in the 1980s either. In 1900 then US Secretary of State John Hay wrote: “the Mediterranean is the ocean of the past, the Atlantic the ocean of the present and the Pacific is the ocean of the future.” In a more general manner, as Christopher Coker has observed, the notion of the “Century of the Pacific” is plausible because it is consistent with the idea, popularized by Hegel, that the spirit of civilization is moving toward that part of the globe. Thus, the century of the Pacific has become a kind of zeitgeist. In this paper I undertake a conceptual, historical, and theoretical journey through the “Pacific Rim” or “Asia-Pacific,” as it has been called more recently. Although I will question the utility of the term, I want to make clear that my purpose is only to undertake a critical survey of “the Pacific.” As in any trip, however, one needs a starting point. But, What is the starting point of the Pacific Rim, that geographic zone that has been compared to Pascal’s sphere: “with periphery indeterminable and a center that may be anywhere”?

  10. Comparative study between 99mTc-diphosphonate bone scintigraphy and 18F-fluoride PET or PET/CT in terms of clinical usefulness and cost-effectiveness in detection of bone disorders

    18F-fluoride ion (18F-NaF) first introduced by Blau in 1962 was approved in 1972 by the Food and Drug Administration (FDA), and 99mTc-diphosphonate becomes the standard bone imaging radiopharmaceutical, with bone scintigraphy performed more than 430000 times a year in Japan. High resolution, high sensitivity and multi-slice positron emission tomography (PET) device appeared from the first half of the 1990's, and systemic three dimensional tomograms became easily obtainable, making it possible for bone PET to search for systemic bony lesions within a short tune. In the Japanese Society of Nuclear Medicine Working Group, we evaluated bone PET and PET/CT as compared with bone scintigraphy in three institutions during a two-year period to determine the clinical usefulness and cost effectiveness of bone PET and PET/CT. Bone PET and PET/CT showed a significant superiority over bone scintigraphy in 67 patients with lytic and sclerotic malignant and benign lesions. We consider based on other studies and our results that bone PET and PET/CT will become routine bone imaging modalities in future. (author)

  11. Bone Markers

    ... resistant Acid Phosphatase; TRAP; Bone-specific Alkaline Phosphatase; Osteocalcin; P1NP; Procollagen Type 1 N-Terminal Propeptide Formal ... be affected by the level of liver ALP. Osteocalcin (bone gla protein) – a protein formed by osteoblasts; ...

  12. Bone Tumor

    ... develop when cells within a bone divide uncontrollably, forming a lump or mass of abnormal tissue. Most ... you have bone cancer, treatment will include a team of doctors from different medical specialties working together ...

  13. Bone tumor

    ... physical exam. Tests that may be done include: Alkaline phosphatase blood level Bone biopsy Bone scan Chest x- ... also affect the results of the following tests: Alkaline phosphatase isoenzyme Blood calcium level Parathyroid hormone Blood phosphorus ...

  14. Seismic Velocity Study of the Rim Uplift of the Steen River Impact Crater

    Niccoli, M.; Hildebrand, A. R.; Lawton, D. C.

    2005-03-01

    The structure of the rim uplift at the 25 km diameter Steen River has been explored by 2D and 3D seismic reflection and refraction techniques, constrained by downhole well surveys. A complicated deformation history is revealed.

  15. Search Efficient Representation of Healthcare Data based on the HL7 RIM

    Razan Paul

    2010-12-01

    Full Text Available The Reference Information Model (RIM of Health Level Seven (HL7 standard is a conceptual information model for health care. Data of HL7 RIM Observation class are sparse, high dimensional, and require frequent schema change. Entity Attribute Value (EAV is the widely used solution to handle these above challenges of medical data, but EAV is not search efficient for knowledge extraction. In this paper, we have proposed a search efficient data model:  Optimized Entity Attribute Value (OEAV for physical representation of medical data as alternative of widely used EAV model. We have implemented EAV or OEAV individually to model RIM Observation class and used relational model for the remaining RIM classes. We have shown that OEAV is dramatically search efficient   and occupy less storage space compared to EAV.

  16. Bone Density

    ... mass that is not low enough to be osteoporosis is sometimes called osteopenia. Causes of low bone mass include family history, not developing good bone mass when you are young, and certain conditions or ... low bone mass gets osteoporosis, but they are at higher risk for getting ...

  17. Subciliary Approach for Inferior Orbital Rim Fractures; Case Series and Literature Review

    Seyed Mohammad Motamed al Shariati; Mostafa Dahmardeh Zahedan; Hassan Ravari

    2014-01-01

    Objectives: To report the outcome of subciliary approach for inferior orbital rim fractures in a series of Iranian patients. Methods: This was prospective cross-sectional, being performed during a 12-month period during 2013 in plastic surgery department of Emamreza Hospital of Mashhad. We included 12 patients with traumatic inferior orbital rim fractures who underwent surgical repair through subciliary approach. All the patients were followed for 12 months and were evaluated regar...

  18. Lateral Orbital Rim Osteotomy in the Treatment of Certain Skull Base Lesions

    Pritz, Michael B.

    2002-01-01

    Quantitative data from a recent human cadaveric study suggested that removal of the lateral orbital rim alone may be sufficient to reach many targets for which the orbitozygomatic craniotomy has been used. Consequently, a lateral orbital rim osteotomy was substituted for an orbitozygomatic craniotomy in seven patients with a variety of pathologies located in the anterior, middle, and interpeduncular fossae. In each case, lateral orbitotomy provided a satisfactory surgical corridor for diagnos...

  19. The Presynaptic Active Zone Protein RIM1α Is Critical for Normal Learning and Memory

    Powell, Craig M; Schoch, Susanne; Monteggia, Lisa; Barrot, Michel; Matos, Maria F.; Feldmann, Nicole; Südhof, Thomas C.; Nestler, Eric J.

    2004-01-01

    The active zone protein RIM1α is required both for maintaining normal probability of neurotransmitter release and for long-term presynaptic potentiation at brain synapses. We now demonstrate that RIM1α−/− mice exhibit normal coordination and anxiety-related behaviors but display severely impaired learning and memory. Mice with a synaptotagmin 1 mutation, which selectively lowers release probability, and mice with Rab3A deletion, which selectively abolishes presynaptic long-term potentiation, ...

  20. Detection of solar wind-produced water in irradiated rims on silicate minerals

    Bradley, John P.; Ishii, Hope A.; Gillis-Davis, Jeffrey J.; Ciston, James; Nielsen, Michael H.; Bechtel, Hans A.; Martin, Michael C.

    2014-01-01

    Whether water is produced by solar wind (SW) radiolysis has been debated for more than four decades. In this paper, we exploit the high spatial resolution of electron microscopy and sensitivity of valence electron energy-loss spectroscopy to detect water (liquid or vapor) in vesicles within (SW-produced) space-weathered rims on interplanetary dust particle (IDP) surfaces. Water in the rims has implications for the origin of water on airless bodies like the Moon and asteroids, the delivery of ...

  1. Signaling events of the Rim101 pathway occur at the plasma membrane in a ubiquitination-dependent manner.

    Obara, Keisuke; Kihara, Akio

    2014-09-15

    In yeast, external alkalization and alteration in plasma membrane lipid asymmetry are sensed by the Rim101 pathway. It is currently under debate whether the signal elicited by external alkalization is transduced to downstream molecules at the plasma membrane or via endocytosis of the Rim21 sensor protein at the late endosome. We found that the downstream molecules, including arrestin-related protein Rim8, calpain-like protein Rim13, and scaffold protein Rim20, accumulated at the plasma membrane upon external alkalization and that the accumulation was dependent on Rim21. Snf7, an endosomal sorting complex required for transport (ESCRT) III subunit also essential for the Rim101 pathway, localized to the plasma membrane, in addition to the late endosome, under alkaline conditions. Snf7 at the plasma membrane but not at the late endosome was shown to be involved in Rim101 signaling. In addition, the Rim101 pathway was normally activated, even when endocytosis was severely impaired. Considering this information as a whole, we propose that Rim101 signaling proceeds at the plasma membrane. We also found that activity of the Rsp5 ubiquitin ligase was required for recruiting the downstream molecules to the plasma membrane, suggesting that ubiquitination mediates Rim101 signaling at the plasma membrane. PMID:25002535

  2. Magnetic field amplification in the thin X-ray rims of SN 1006

    Several young supernova remnants, including SN 1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50-100 μG fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, D∝E μ. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the FWHM in terms of energy as FWHM ∝EγmE. Filament widths in SN 1006 decrease with energy; mE ∼ –0.3 to –0.8, implying magnetic field amplification by factors of 10-50, above the factor of four expected in strong unmodified shocks. For SN 1006, the rapid shrinkage rules out magnetic damping models. It also favors short mean free paths (small diffusion coefficients) and strong dependence of D on energy (μ ≥ 1).

  3. Magnetic-Field Amplification in the Thin X-ray Rims of SN1006

    Ressler, Sean M; Reynolds, Stephen P; Long, Knox S; Petre, Robert; Williams, Brian J; Winkler, P Frank

    2014-01-01

    Several young supernova remnants (SNRs), including SN1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50 to $100 \\mu$G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic-field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic-field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, $D \\propto E^{\\mu}$. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the full widths at half maximum (FWHM) in terms of energy as FW...

  4. Bone poroelasticity.

    Cowin, S C

    1999-03-01

    Poroelasticity is a well-developed theory for the interaction of fluid and solid phases of a fluid-saturated porous medium. It is widely used in geomechanics and has been applied to bone by many authors in the last 30 years. The purpose of this work is, first, to review the literature related to the application of poroelasticity to the interstitial bone fluid and, second, to describe the specific physical and modeling considerations that establish poroelasticity as an effective and useful model for deformation-driven bone fluid movement in bone tissue. The application of poroelasticity to bone differs from its application to soft tissues in two important ways. First, the deformations of bone are small while those of soft tissues are generally large. Second, the bulk modulus of the mineralized bone matrix is about six times stiffer than that of the fluid in the pores while the bulk moduli of the soft tissue matrix and the pore water are almost the same. Poroelasticity and electrokinetics can be used to explain strain-generated potentials in wet bone. It is noted that strain-generated potentials can be used as an effective tool in the experimental study of local bone fluid flow, and that the knowledge of this technique will contribute to the answers of a number of questions concerning bone mineralization, osteocyte nutrition and the bone mechanosensory system. PMID:10093022

  5. Comperative study on four different radiographic technics to image the navicular bone

    In this paper the conventional x-ray technique according to Oxspring is compared with tomography and digitalized picture techniques (digital luminescent radiography, computed tomography, nuclear magnetic resonance tomography) to establish whether an improved picture of the equine navicular bone is possible. Because of a lack of detail, nuclear magnetic resonance tomography and digital luminescent radiography show no advantage. With tomography good picture of the navicular bone as well as the sesamoidian canals is gained, but the bone structure is not sharply visible. In spite of small losses in picture resolution, the computed tomography gives a picture with good contour and bone structure as well as an excellent differentiation between the density of spongiotic and sclerotic bone. When considering the picture quality (contour and structure of the navicular bone as well as number, shape, depth and surroundings of the sesamoidian canals), costs and technical possibilities of the examination procedures, the x-ray technique according to Oxspring still remains the method of choice in examining the equine navicular bone

  6. Investigations into the value of bone scintigrams in fracture of the navicular bone

    The diagnostic value of bone scintigrams was investigated in a group of 22 patients showing fractured navicular bones and contrasted with that of X-ray pictures and clinical evaluations. The changes revealed by radiology were pseudarthrosis (9 patients), complete fracture (10 patients) as well as cysts and sclerotic processes (3 patients). Eight out of 9 cases of pseudarthrosis, 6 of the 10 complete fractures and 2 of the 3 cysts were confirmed by corresponding pathological changes in the scintigrams. The X-ray pictures and clinical evaluations led to consistent results in 14 patients, conformity of the scintigrams and clinical findings was seen in 17 cases and of the X-ray pictures and scintigrams in 15 cases. The results of the study give evidence of the fact that scintigrams recorded after injection of 99 mTc MDP are primarily suitable to diagnose incipient pathological changes in the tissue adjacent to the fracture. Their use is justified in discrepancies between the clinical and radiological findings or in cases, where conventional X-rays yielded doubtful results as to the therapeutic strategy or incapacitation of the patient. (TRV)

  7. Malignant bone pain: pathophysiology and treatment.

    Mercadante, S

    1997-01-01

    The presence of bone metastases predicts the presence of pain and is the most common cause of cancer-related pain. Although bone metastases do not involve vital organs, they may determine deleterious effects in patients with prolonged survival. Bone fractures, hypercalcaemia, neurologic deficits and reduced activity associated with bone metastases result in an overall compromise in the patient's quality of life. A metastasis is a consequence of a cascade of events including a progressive growth at the primary site, vascularization phase, invasion, detachment, embolization, survival in the circulation, arrest at the site of a metastasis, extravasion, evasion of host defense and progressive growth. Once cancer cells establish in the bone, the normal process of bone turnover is disturbed. The different mechanisms responsible for osteoclast activation correspond to typical radiologic features showing lytic, sclerotic or mixed metastases, according to the primary tumor. The release of chemical mediators, the increased pressure within the bone, microfractures, the stretching of periosteum, reactive muscle spasm, nerve root infiltration and compression of nerves by the collapse of vertebrae are the possible mechanisms of malignant bone pain. Pain is often disproportionate to the size or degree of bone involvement. A comprehensive assessment including a trusting relationship with the patient, taking a careful history of the pain complaint, the characteristics of the pain, the evaluation of the psychological status of the patient, neurological examination, the reviewing of diagnostic studies and laboratory findings, and individualization of the therapeutic approach, should precede any treatment. Radiotherapy is the cornerstone of the treatment. Low doses given in a single session are safe and effective, and reduce distress and inconvenience associated with repeated session. Radioisotopes are more imprecise in delivering specific doses of radiation, but have less toxicity and easy administration as well as effectiveness in subclinical sites of metastases, although storage, dispensing and administration should be under strict control. Chemotherapy and endocrine therapy are difficult to measure in terms of pain relief. Prophylactic fixation surgery can lead to improved survival and quality of life of patients with bone metastases. Surgical treatment should be undertaken when fracture occurs. Careful selection of patients for surgical spinal decompression is required. The potential benefits of surgical interventions have to be tempered with patient survival. The use of analgesics according to the WHO ladder is recommended. There is no clear evidence that non-steroidal anti-inflammatory drugs (NSAIDs) have a specific efficacy in malignant bone pain. The difficulty with incident pain is not a lack of response to systemic opioids, but rather that the doses required to control the incidental pain produce unacceptable side-effects at rest. Alternative measures are often required. The inhibition of bone resorption and hypercalcaemia can be reduced by the use of bisphosphonates. This class of drugs potentiate the effects of analgesics in improving metastatic bone pain. Invasive techniques are rarely indicated, but may provide analgesia in the treatment of pain resistant to the other modalities. Neural blockade should never be used as the sole modality for malignant bone pain, but should be considered as a helpful in specific pain situations. Careful appraisal and the application of a correct approach should enable the patient with bone metastases to obtain an acceptable pain relief despite the advanced nature of their malignant disease. PMID:9060007

  8. Bone Lesions and Damage

    ... NOW Home » About Multiple Myeloma » Symptoms » Bone Damage Bone Lesions and Damage Bone lesions from multiple myeloma ... evaluate bone damage in myeloma patients. Causes of bone destruction in myeloma Normally, osteoclasts function with bone- ...

  9. 99mTc MDP bone scan in evaluation of painful scoliosis

    A 18-year-old male presented with low back ache. The patient was investigated and was diagnosed to have painful scoliosis. X-ray and other examinations could not reveal any diagnosis. The patient was referred to undergo bone scan on clinical suspicion of osteoid osteoma and to rule out stress fracture if any. Planar bone scan was performed, which showed a lesion in L3 vertebra and was further evaluated with SPECT (Single photon emission computed tomography) study to characterize the lesion. On SPECT examination, the classical features of osteoid osteoma, the double density sign (11), was noted in the pars interarticularis region. These findings were confirmed by a CT scan, which showed a sclerotic lesion in pars interarticularis of L3 vertebra. The patient was posted for operation and was relieved of symptoms in the postoperative follow-up. (author)

  10. Subsidence and basin-fill architecture of a lignite-bearing salt rim syncline: insights into rim syncline evolution and salt diapirism

    Brandes, C.; Pollok, L.; Schmidt, C.; Wilde, V.; Winsemann, J.

    2012-04-01

    In the last decades, salt-withdrawal basins achieved much attention due to their significant hydrocarbon potential like in the Gulf of Mexico, along the Brazilian passive margin and in northern Germany. The Helmstedt-Staßfurt salt wall and the related Schöningen rim syncline are an ideal natural laboratory to study the evolution of salt-withdrawal basins in detail. An excellent data set of 358 wells allows a detailed assessment of the basin-fill architecture. The aim was to expand on the classical cross-section based rim syncline analysis by the use of 3D models and basin simulations. The Helmstedt-Staßfurt salt wall is 70 km long, 6-8 km wide and one of the most important diapiric structures in northern Germany, based on the economically significant lignite-bearing rim synclines. The analysed Schöningen rim syncline, located on the southwestern side of the Helmstedt-Staßfurt structure, is 8 km long and 3 km wide. The basin-fill is up to 366 m thick and contains 13 major lignite seams with thicknesses between 0.1 and 30 m. Cross-sections perpendicular to the basin axis indicate that the basin-fill has a pronounced lenticular shape. This shape varies from more symmetric in the NW to clearly asymmetric in the SE. It coincides to the broadening of the salt diapir from NW to SE. The geometry of the rim syncline therefore seems to be a function of the diapir morphology. Sediments close to a diapir margin tend to be sheared by the rising diapir and this effect is probably enhanced where the diapir becomes broader and as a result, the related rim syncline is more asymmetric. Isopach maps imply a two-fold depocentre evolution. The depocentre migrated over time towards the salt wall and also showed some distinct shifts parallel to the salt wall. The shifts parallel to salt wall were abrupt, in contrast to the more gradual migration of the depocentres perpendicular to the salt wall. The basin modelling part of the study was carried out with the software PetroMod®, which focused on the burial history of the rim syncline. Modeling results also show the progressive migration of the rim syncline depocenter towards the salt wall. The extracted geohistory curve shows initial rapid subsidence between 57 and 50 Ma and more moderate subsidence from 50 to 34 Ma. This pattern is interpreted to reflect salt migration from the source layer into the salt wall. The initial salt-withdrawal rate was rapid but later decreased probably due to depletion of the source layer. From a regional perspective, the sediments associated with the salt wall vary in age along strike. The oldest sediments are present at the northwestern and southeastern ends of the structure. The youngest sediments are present towards the central part of the salt wall. This age pattern implies that the break-through of the salt wall was initiated at the edges. The evolution of the Helmstedt-Staßfurt salt wall can be subdivided into the three stages reactive, active and passive diapirism. Initial salt rise was probably triggered by extension. Diapirism was enhanced due to contraction during the Late Cretaceous. The salt movements in the Tertiary were mainly driven by sediment loading in the rim synclines.

  11. [Bone diseases].

    Uebelhart, Brigitte; Rizzoli, René

    2016-01-13

    Calcium intake shows a small impact on bone mineral density and fracture risk. Denosumab is a more potent inhibitor of bone resorption than zoledronate. Abaloparatide, PTHrP analog, increases bone mineral density and decreases fracture incidence. Teriparatide could be delivered via a transdermic device. Romosozumab and odanacatib improve calculated bone strength. Sequential or combined treatments with denosumab and teriparatide could be of interest, but not denosumab followed by teriparatide. Fibrous dysplasia, Paget disease and hypophosphatasia are updated, as well as atypical femoral fracture and osteonecrosis of the jaw. PMID:26946704

  12. Acetabular rim and surface segmentation for hip surgery planning and dysplasia evaluation

    Tan, Sovira; Yao, Jianhua; Yao, Lawrence; Summers, Ronald M.; Ward, Michael M.

    2008-03-01

    Knowledge of the acetabular rim and surface can be invaluable for hip surgery planning and dysplasia evaluation. The acetabular rim can also be used as a landmark for registration purposes. At the present time acetabular features are mostly extracted manually at great cost of time and human labor. Using a recent level set algorithm that can evolve on the surface of a 3D object represented by a triangular mesh we automatically extracted rims and surfaces of acetabulae. The level set is guided by curvature features on the mesh. It can segment portions of a surface that are bounded by a line of extremal curvature (ridgeline or crestline). The rim of the acetabulum is such an extremal curvature line. Our material consists of eight hemi-pelvis surfaces. The algorithm is initiated by putting a small circle (level set seed) at the center of the acetabular surface. Because this surface distinctively has the form of a cup we were able to use the Shape Index feature to automatically extract an approximate center. The circle then expands and deforms so as to take the shape of the acetabular rim. The results were visually inspected. Only minor errors were detected. The algorithm also proved to be robust. Seed placement was satisfactory for the eight hemi-pelvis surfaces without changing any parameters. For the level set evolution we were able to use a single set of parameters for seven out of eight surfaces.

  13. Ancient stardust in fine-grained chondrule dust rims from carbonaceous chondrites

    Leitner, Jan; Vollmer, Christian; Floss, Christine; Zipfel, Jutta; Hoppe, Peter

    2016-01-01

    Carbonaceous chondrites are fragments from primitive parent asteroids, which represent some of the most primitive meteorites accessible for laboratory analysis and offer therefore the best opportunity to explore the chemical and physical conditions in the early Solar System. Here, we report the identification of presolar grains, which are circumstellar condensates that date back from before the formation of our Solar System, in fine-grained dust rims around chondrules in carbonaceous chondrites. Average presolar grain abundances in the rims of aqueously altered chondrites (petrologic type 2) are three times higher than in the respective interchondrule matrices, while for the most pristine specimens (petrologic type 3), the opposite is observed. The presence of these grains implies a nebular origin of the rim material, and gives evidence for differing alteration pathways for different reservoirs of fine-grained material found in primitive meteorites. Moreover, our findings indicate formation of the fine-grained rims in the solar nebula prior to parent-body accretion, giving support to accretionary scenarios for parent-bodies in the presence of dust-rimmed chondrules.

  14. Heat/Mass Transfer Measurement on The Tip Surface Of Rotor Blade With Squlear Rim

    Park, Jun Su; Lee, Dong Hyun; Lee, Woo Jin; Cho, Hyung Hee; Rhee, Dong-Ho; Kang, Shin-Hyung

    2010-06-01

    The present study investigates local heat/mass transfer characteristics on blade tip surface with squealer rim. A linear cascade experimental setup consists of three large scale airfoils was used. The axial chord length and turning angle of test blade are 237 mm and 126°, respectively. Heat/mass transfer coefficients were measured with three different rim heights (3%, 6% and 9% of axial chord length) and fixed tip clearance (2% of axial chord length). Main flow Reynolds number based on axial chord length is 1.5×105. Naphthalene sublimation method is used to measure the detailed mass transfer coefficient on the blade tip surface. The heat/mass transfer results show that as the rim height increases, the peak values on the upstream region of the tip surface decreases and moves to the suction side rim. At the downstream region of the tip surface, the pitch-wise averaged heat/mass transfer coefficients increases as the rim height increases.

  15. PATHOLOGIC BASIS FOR RIM ENHANCEMENT OBSERVED IN COMPUTED TOMOGRAPHIC IMAGES OF FELINE NASOPHARYNGEAL POLYPS.

    Lamb, Christopher R; Sibbing, Kendall; Priestnall, Simon L

    2016-03-01

    In postcontrast computed tomographic (CT) images, feline nasopharyngeal polyps typically demonstrate enhancement of the peripheral rim. Computed tomographic images and histologic specimens of a case series of 22 cats with surgically removed nasopharyngeal polyps were reviewed retrospectively in an attempt to elucidate the origin of rim enhancement. Polyps were present in the tympanic cavity in 15 (68%) cats (three with extension into the nasopharynx), only in the nasopharynx in four (18%) cats, and only in the external ear canal in the remaining three (14%) cats. All polyps had variable degrees of epithelial injury. Hemorrhage and inflammatory infiltration were significantly more marked in the superficial stroma whereas edema was significantly more marked in the core stroma. In noncontrast CT images (n = 22), the tympanic bulla was thickened in all 15 cats with a polyp in the tympanic cavity and enlarged in eight (53%) of these cats. In postcontrast CT images (n = 15), an outer zone of relatively increased attenuation compatible with a rim was observed in 11 (73%) polyps. The magnitude and extent of rim enhancement in CT images was positively correlated with the histologic grade of inflammation in the superficial stroma and negatively correlated with the grade of edema in the superficial stroma. It appears that inflammation is the major determinant of contrast medium accumulation in feline nasopharyngeal polyps, and the tendency for inflammation to affect predominantly the superficial layers explains the frequent observation of a rim in postcontrast CT images. PMID:26763944

  16. Mechanical fracture study of nuclear fuel high burn-up structure (HBS or RIM) during annealing test; Etude de la fracturation mecanique de la structure a haut taux de combustion des combustibles irradies (RIM) en traitement thermique

    Marcet, M.

    2010-12-07

    The ceramics used in Power Water Reactors ar made of uranium dioxide. Irradiated at high Burn-up, they present a characteristic zone in periphery called High Burn-Up Structure or RIM zone with micrometer pores containing over-pressurized gas bubbles. Annealing texts simulating incidental or accidental reactor situations, a strong release of the RIM zone is observed. We have considered that the fission gas release mechanism is the mechanical fracture of the RIM grain boundaries. The we have compared the different types of mechanical stress applied to a grain boundary with the fracture stress of the oxide. The first stress is due to RIM over-pressurized gas bubbles, these bubbles apply a stress field determined at a microscopic level i.e. at the gas bubbles scale and its local environment. The second stress is generated by the Pellet-Cladding Mechanical Interaction (PCMI). This stress applies a stress field on a microscopic scale i.e. at the RIM zone and its overall environment. The last stress is occurred by a strain due to the RIM structural evolution during annealing test. The experimental results show that microscopic and macroscopic stress fields to do not explain the RIM grain boundary fracture during annealing test. The stresses induced by the RIM structural evolution as a function of the temperature is a possible mechanism to explain the overall mechanical behavior of the RIM zone during annealing test. (author)

  17. Comparison of the RIM-H rapid identification kit with conventional tests for the identification of Haemophilus spp.

    PALLADINO, S.; Leahy, B J; Newall, T L

    1990-01-01

    A commercially available system, the RIM-H system (Austin Biological Laboratories, Austin, Tex.), was evaluated for its ability to rapidly and accurately identify various Haemophilus spp. A total of 110 clinical isolates were tested by both the RIM and conventional identification procedures. The RIM agreed with the standard identification for 100% of the Haemophilus influenzae (76 of 76) and 92.0% of the Haemophilus parainfluenzae (23 of 25) isolates tested. The identifications of Haemophilus...

  18. Singly reflected skew rays inside a hollow tube: an exact cardiold solution for incident rim rays.

    Pike, J N

    1991-08-01

    Diffuse light entering a hollow cylindrical tube forms a manifold of concentric bright bands as a result of multiple internal reflections. A circular occulting stop, filling the entrance aperture except for a narrow rim annulus, converts these successive bands into sharply bounded rings, the first of which is produced solely by singly reflected skew and meridional rays. The exact geometrical optics of all rays emitted by any point on the rim are considered, and it is shown that after a single reflection all such rays appear to arise from a single cardioid curve. When rotated about the optic axis, this cardioid predicts the flaring ring intensity distribution observed. (Any departure of this first ring from concentricity around the direct image of the rim annulus provides a quantitative measure of nonstraightness of the tube.). PMID:20706383

  19. Cracking of an Aircraft Wheel Rim Made From Al-Alloy 2014-T6

    G. Kosec

    2010-10-01

    Full Text Available Generally failures of different aircraft components and parts are revealed and examined by the use of non-destructive examination methods. In further detailed explanation and interpretation of failures optical and scanning electron microscopy are used. This paper deals with a problem of a crack on aircraft wheel rim made from aluminium alloy 2014-T6.The crack was observed during regular control by the maintenance unit for non-destructive examination of the Slovenian air carrier Adria Airways. The crack on the rim of an aircraft wheel investigated was a typical fatigue crack. At same time a numerous pits were found which served as stress concentrations on the rim surface.

  20. Mechanical fracture study of nuclear fuel high burn-up structure (HBS or RIM) during annealing test

    The ceramics used in Power Water Reactors ar made of uranium dioxide. Irradiated at high Burn-up, they present a characteristic zone in periphery called High Burn-Up Structure or RIM zone with micrometer pores containing over-pressurized gas bubbles. Annealing texts simulating incidental or accidental reactor situations, a strong release of the RIM zone is observed. We have considered that the fission gas release mechanism is the mechanical fracture of the RIM grain boundaries. The we have compared the different types of mechanical stress applied to a grain boundary with the fracture stress of the oxide. The first stress is due to RIM over-pressurized gas bubbles, these bubbles apply a stress field determined at a microscopic level i.e. at the gas bubbles scale and its local environment. The second stress is generated by the Pellet-Cladding Mechanical Interaction (PCMI). This stress applies a stress field on a microscopic scale i.e. at the RIM zone and its overall environment. The last stress is occurred by a strain due to the RIM structural evolution during annealing test. The experimental results show that microscopic and macroscopic stress fields to do not explain the RIM grain boundary fracture during annealing test. The stresses induced by the RIM structural evolution as a function of the temperature is a possible mechanism to explain the overall mechanical behavior of the RIM zone during annealing test. (author)

  1. Opportunity, Geologic and Structural Context of Aqueous Alteration in Noachian Outcrops, Marathon Valley and Rim and Endeavour Crater

    Crumpler, L. S.; Arvidson, R. E.; Mittlefehldt, D. W.; Jolliff, B. L.; Farrand, W. H.; Fox, V.; Golombek, M. P.

    2016-01-01

    In its 12th year of exploration and 1600 sols since arrival at the rim of the 22 km-diameter Noachian Endeavour impact crater, Mars Exploration Rover Opportunity traversed from the summit of the western rim segment "Cape Tribulation" to "Marathon Valley", a shallow trough dissecting the rim and the site of strong orbital detection of smectites. In situ analysis of the exposures within Marathon Valley is establishing some of the geologic and geochemical controls on the aqueous alteration responsible for smectite detection known to occur in crater rims throughout Noachian terrains of Mars.

  2. Talking Bones.

    Johnson, Jaclyn; Kassing, Sharon

    2002-01-01

    Describes cooperation with the Saint Louis Zoo to provide opportunities for elementary school students to learn about bones, how animals move, what they eat, and how much they grow. Uses biofacts which include bones, skulls, and other parts to make the laboratory a hands-on experience for students. (YDS)

  3. Your Bones

    ... ride your bike, eat cereal, and play a video game — the ones that allow you to twist, bend, ... and playing sports. Take these steps to be good to your bones, and they will treat you right! Reviewed by: Steven Dowshen, MD Date reviewed: August ... MORE ON THIS TOPIC Getting an X-ray (Video) Strains and Sprains Are a Pain Movie: Bones & ...

  4. A simplified procedure for preparation of undecalcified human bone sections

    Wallin, J A; Tkocz, I; Levinsen, J

    1985-01-01

    A new type of apparatus for sectioning samples of hard, undecalcified bone is described. Slices of fresh or archeological human bone 4-5 mm thick are dehydrated and then embedded in epoxy resin. The apparatus used to prepare sections from the resulting blocks consists of a low-speed rim......-type diamond cut-off wheel and a slowly advancing table carrying the specimen held in a rotating mount. Sections may be cut at a thickness of 80 micron +/- 1%. After cleaning in an ultrasonic bath, these can be mounted on slides for quantitative microscopic examination with transmitted light. Grinding and...

  5. Bone densitometry

    Ravn, Pernille; Alexandersen, P; Møllgaard, A

    1999-01-01

    The bisphosphonates have been introduced as alternatives to hormone replacement therapy (HRT) for the treatment and prevention of postmenopausal osteoporosis. The expected increasing application in at clinical practice demands cost-effective and easily handled methods to monitor the effect on bone....... The weak response at the distal forearm during antiresorptive treatment has restricted the use of bone densitometry at this region. We describe a new model for bone densitometry at the distal forearm, by which the response obtained is comparable to the response in other regions where bone densitometry...... is much more expensive and technically complicated. By computerized iteration of single X-ray absorptiometry forearm scans we defined a region with 65% trabecular bone. The region was analyzed in randomized, double-masked, placebo- controlled trials: a 2-year trial with alendronate (n = 69), a 1-year...

  6. Young Stellar Population of the Bright-Rimmed Clouds BRC 5, BRC 7 and BRC 39

    Panwar, Neelam; W. P. Chen(Graduate Institute of Astronomy, National Central University, 300 Jhongda Rd., Jhongli 32001, Taiwan); Pandey, A. K.; Samal, M. R.; Ogura, K.; Ojha, D. K.; Jose, J.; Bhatt, B. C.

    2014-01-01

    Bright-rimmed clouds (BRCs), illuminated and shaped by nearby OB stars, are potential sites of recent/ongoing star formation. Here we present an optical and infrared photometric study of three BRCs: BRC 5, BRC 7 and BRC 39 to obtain a census of the young stellar population, thereby inferring the star formation scenario, in these regions. In each BRC, the Class I sources are found to be located mostly near the bright rim or inside the cloud, whereas the Class II sources are preferentially outs...

  7. Search for triggered star formation in the type A bright rimmed cloud 34

    Garmire, Gordon

    2008-09-01

    Bright rimmed clouds (BRCs) near OB stars are excellent laboratories for the study of triggered star formation (TSF) due to the radiation driven implosion (RDI) mechanism. Type A BRCs are clouds at their earliest evolutionary stages and, according to the current theoretical modeling, are not expected to exhibit RDI TSF yet. Employing the Chandra's ability to effectively discern young stellar populations from unrelated old field objects we propose to observe the nearby Type A bright rimmed cloud BRC 34 and test predictions of RDI modelling. BRC 34 will also complement our large GO project on BRCs with the aim to study the RDI star formation efficiency in the Galaxy.

  8. Amphibole reaction rims as a record of pre-eruptive magmatic heating: An experimental approach

    De Angelis, S. H.; Larsen, J.; Coombs, M.; Dunn, A.; Hayden, L.

    2015-09-01

    Magmatic minerals record the pre-eruptive timescales of magma ascent and mixing in crustal reservoirs and conduits. Investigations of the mineral records of magmatic processes are fundamental to our understanding of what controls eruption style, as ascent rates and magma mixing processes are well known to control and/or trigger potentially hazardous explosive eruptions. Thus, amphibole reaction rims are often used to infer pre-eruptive magma dynamics, and in particular to estimate magma ascent rates. However, while several experimental studies have investigated amphibole destabilization during decompression, only two investigated thermal destabilization relevant to magma mixing processes. This study examines amphibole decomposition experimentally through isobaric heating of magnesio-hornblende phenocrysts within a natural high-silica andesite glass. The experiments first equilibrated for 24 h at 870 °C and 140 MPa at H2O-saturated conditions and ƒO2 ∼ Re-ReO prior to rapid heating to 880, 900, or 920 °C and hold times of 3-48 h. At 920 °C, rim thicknesses increased from 17 μm after 3 h, to 55 μm after 12 h, and became pseudomorphs after longer durations. At 900 °C, rim thicknesses increased from 7 μm after 3 h, to 80 μm after 24 h, to pseudomorphs after longer durations. At 880 °C, rim thicknesses increased from 7 μm after 3 h, to 18 μm after 36 h, to pseudomorphs after 48 h. Reaction rim microlites vary from 5-16 μm in size, with no systematic relationship between crystal size and the duration or magnitude of heating. Time-averaged rim microlite growth rates decrease steadily with increasing experimental duration (from 3.97 ×10-7 mms-1 to 3.1 to 3.5 ×10-8 mms-1). Time-averaged microlite nucleation rates also decrease with increasing experimental duration (from 1.2 ×103mm-3s-1 to 5.3 mm-3 s-1). There is no systematic relationship between time-averaged growth or nucleation rates and the magnitude of the heating step. Ortho- and clinopyroxene together constitute 57-90 modal % mineralogy in each reaction rim. At constant temperature, clinopyroxene abundances decrease with increasing experimental duration, from 72 modal % (3 h at 900 °C) to 0% (48 h at 880 °C, and 36 h at 900 and 920 °C). Fe-Ti oxides increase from 6-12 modal % (after 3-6 h) to 26-34 modal % (after 36-48 h). Plagioclase occurs in relatively minor amounts (500 μm from reacted amphibole) are consistent with inter-microlite rim glasses (71.3-77.7 wt.% SiO2) within a given experiment and there is a weakly positive correlation between increasing run duration and inter-microlite melt SiO2 (68.9-78.5 wt.%). Our results indicate that experimental heating-induced amphibole reaction rims have thicknesses, textures, and mineralogies consistent with many of the natural reaction rims seen at arc-andesite volcanoes. They are also texturally consistent with experimental decompression reaction rims. On this basis it may be challenging to distinguish between decompression and heating mechanisms in nature.

  9. Bone development

    Tatara, M.R.; Tygesen, Malin Plumhoff; Sawa-Wojtanowicz, B.; Krupski, W.; Majcher, P.; Harrison, Adrian Paul

    The objective of this study was to determine the long-term effect of alpha-ketoglutarate (AKG) administration during early neonatal life on skeletal development and function, with emphasis on bone exposed to regular stress and used to serve for systemic changes monitoring, the rib. Shropshire ram.......01). Furthermore, AKG administration induced significantly higher bone mineral density of the cortical bone by 7.1% (P<0.01) and improved the mechanical endurance of ribs in terms of the moments of maximum elastic strength and ultimate strength by 10% and 8%, respectively (P<0.05). It could be concluded that AKG...

  10. 78 FR 15920 - Federal Motor Vehicle Safety Standards; Tire Selection and Rims

    2013-03-13

    ... revisions to the tire standards and to the rim and labeling requirements for motor vehicles. \\1\\ 68 FR 38116... Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78). Docket: For access to the... time from publication of the final rule.\\2\\ \\2\\ See 71 FR 877 (Jan. 6, 2006). The agency has been...

  11. Incident laser modulation of a repaired damage site with a rim in fused silica rear subsurface

    Local CO2 laser treatment has proved to be an effective method to prevent the 351-nm laser-induced damage sites in a fused silica surface from exponentially growing, which is responsible for limiting the lifetime of optics in high fluence laser systems. However, the CO2 laser induced ablation crater is often surrounded by a raised rim at the edge, which can also result in the intensification of transmitted ultraviolet light that may damage the downstream optics. In this work, the three-dimensional finite-difference time-domain method is developed to simulate the distribution of electrical field intensity in the vicinity of the CO2 laser mitigated damage site located in the exit subsurface of fused silica. The simulated results show that the repaired damage sites with raised rims cause more notable modulation to the incident laser than those without rims. Specifically, we present a theoretical model of using dimpled patterning to control the rim structure around the edge of repaired damage sites to avoid damage to downstream optics. The calculated results accord well with previous experimental results and the underlying physical mechanism is analysed in detail. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  12. 77 FR 18997 - Rim Lakes Forest Restoration Project; Apache-Sitgreavese National Forest, Black Mesa Ranger...

    2012-03-29

    ... Lakes Project Area to make--over time--the forest ecosystem more sustainable and resilient to natural... Forest Service Rim Lakes Forest Restoration Project; Apache-Sitgreavese National Forest, Black Mesa Ranger District, Coconino County, AZ AGENCY: Forest Service, USDA. ACTION: Notice of intent to prepare...

  13. Opportunities for Partnership in the Pacific Rim: Reflections on a Visit to Vietnam.

    Sykes, Abel B., Jr.

    Community colleges are poised to play a vital role in Vietnam and other Pacific Rim nations currently seeking to develop their business sectors and economies. Projects and partnerships with U.S. community colleges are currently in progress in India, Malaysia, China, Japan, Taiwan, and Korea. In addition, the Vietnamese Ministry of Education and…

  14. Effect of centrifugal load on crack path in thin-rimmed and webbed gears

    F. Curà

    2015-10-01

    Full Text Available Thin rimmed and webbed gears are used in particular applications to reduce systems weight. This kind of gears need an accurate and fail safe design. As a matter of fact, a possible failure, due to bending fatigue, consists in crack nucleation and consequent growth, in particular in the tooth root zone. These cracks may propagate through the tooth or through the rim. Crack propagation direction is basically influenced by the wheel geometry parameters, above all the rim thickness. Studies available in literature emphasize three ranges for the backup ratio values, involving different behaviors. These ranges are related to the crack propagation paths; respectively through the tooth, through the rim and in an unforeseeable way. This last uncertainty zone depends on other parameters, related to both geometry and loading conditions. In this work the effect of wheel speed related to the bending load has been investigated. The investigation has been carried out by means of numerical models involving both 2D finite element and extended finite element models (XFEM. Results shows that both crack initiation point and crack propagation path are strongly influenced by centrifugal load; this effect is mainly evident in the uncertainty zone of the backup ratio

  15. RIMS/sup tm/ - radiological information management system: software package EI-029-S86

    1988-01-01

    RIMS/sup tm/ has been developed for health physics record keeping and reporting. It provides for the management needs relating to radiological information control at a nuclear facility. The program is comprised of the following modules: Personnel Radiological Information, Radiological Work Permit, Radiation Survey Records, Access Control, ALARA Reporting, and Respirator and Survey Instrument Inventory Modules.

  16. RIMS/sup tm/ - radiological information management system: software package EI-029-S86

    RIMS/sup tm/ has been developed for health physics record keeping and reporting. It provides for the management needs relating to radiological information control at a nuclear facility. The program is comprised of the following modules: Personnel Radiological Information, Radiological Work Permit, Radiation Survey Records, Access Control, ALARA Reporting, and Respirator and Survey Instrument Inventory Modules

  17. Constraints on the height of the inner disk rim in pre-main-sequence stars

    Vinkovi?, Dejan

    2014-01-01

    The structure of inner region of protoplanetary disks around young pre-main-sequence stars is still poorly understood. This part of the disk is shaped by various forces influencing dust and gas dynamics and by dust sublimation, which creates abrupt drops in the dust density. This region also emits a strong near-infrared excess that cannot be explained by classical accretion disk models, which suggests the existence of some unusual dust distribution or disk shape. The most prevalent explanation to date is the puffed-up inner disk rim model, where the disk exhibits an optically thin cavity around the star up to the distance of dust sublimation. The critical parameter in this model is the inner disk rim height $z_{\\rm max}$ relative to the rim's distance from the star $R_{\\rm in}$. Observations often require $z_{\\rm max}/R_{\\rm in}\\gtrsim0.2$ to reproduce the near-infrared excess in the spectra. In this paper we put together a comprehensive list of processes that can shape the inner disk rim and combined them to...

  18. A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity.

    Read, Timothy; Richmond, Phillip A; Dowell, Robin D

    2016-01-01

    Most genetic variants associated with disease occur within regulatory regions of the genome, underscoring the importance of defining the mechanisms underlying differences in regulation of gene expression between individuals. We discovered a pair of co-regulated, divergently oriented transcripts, AQY2 and ncFRE6, that are expressed in one strain of Saccharomyces cerevisiae, ∑1278b, but not in another, S288c. By combining classical genetics techniques with high-throughput sequencing, we identified a trans-acting single nucleotide polymorphism within the transcription factor RIM101 that causes the background-dependent expression of both transcripts. Subsequent RNA-seq experiments revealed that RIM101 regulates many more targets in S288c than in ∑1278b and that deletion of RIM101 in both backgrounds abrogates the majority of differential expression between the strains. Strikingly, only three transcripts undergo a significant change in expression after swapping RIM101 alleles between backgrounds, implying that the differences in the RIM101 allele lead to a remarkably focused transcriptional response. However, hundreds of RIM101-dependent targets undergo a subtle but consistent shift in expression in the S288c RIM101-swapped strain, but not its ∑1278b counterpart. We conclude that ∑1278b may harbor a variant(s) that buffers against widespread transcriptional dysregulation upon introduction of a non-native RIM101 allele, emphasizing the importance of accounting for genetic background when assessing the impact of a regulatory variant. PMID:26751950

  19. A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity

    Read, Timothy; Richmond, Phillip A.; Dowell, Robin D.

    2016-01-01

    Most genetic variants associated with disease occur within regulatory regions of the genome, underscoring the importance of defining the mechanisms underlying differences in regulation of gene expression between individuals. We discovered a pair of co-regulated, divergently oriented transcripts, AQY2 and ncFRE6, that are expressed in one strain of Saccharomyces cerevisiae, ?1278b, but not in another, S288c. By combining classical genetics techniques with high-throughput sequencing, we identified a trans-acting single nucleotide polymorphism within the transcription factor RIM101 that causes the background-dependent expression of both transcripts. Subsequent RNA-seq experiments revealed that RIM101 regulates many more targets in S288c than in ?1278b and that deletion of RIM101 in both backgrounds abrogates the majority of differential expression between the strains. Strikingly, only three transcripts undergo a significant change in expression after swapping RIM101 alleles between backgrounds, implying that the differences in the RIM101 allele lead to a remarkably focused transcriptional response. However, hundreds of RIM101-dependent targets undergo a subtle but consistent shift in expression in the S288c RIM101-swapped strain, but not its ?1278b counterpart. We conclude that ?1278b may harbor a variant(s) that buffers against widespread transcriptional dysregulation upon introduction of a non-native RIM101 allele, emphasizing the importance of accounting for genetic background when assessing the impact of a regulatory variant. PMID:26751950

  20. 76 FR 69720 - NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    2011-11-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market... in the above-referenced proceeding of NaturEner Rim Rock Wind Energy, LLC's application for...

  1. The kinetics of dolomite reaction rim growth under isostatic and non-isostatic pressure conditions

    Helpa, V.; Rybacki, E.; Morales, L. G.; Abart, R.; Dresen, G. H.

    2013-12-01

    During burial and exhumation, rocks are simultaneously exposed to metamorphic reactions and tectonic stresses. Therefore, the reaction rate of newly formed minerals may depend on chemical and mechanical driving forces. Here, we investigate the reaction kinetics of dolomite (CaMg[CO3]2) rim growth by solid-state reactions experiments on oriented calcite (CaCO3) and magnesite (MgCO3) single crystals under isostatic and non-isostatic pressure conditions. Cylindrical samples of 3-5 mm length and 7 mm diameter were drilled and polished perpendicular to the rhombohedral cleavage planes of natural clear crystals. The tests were performed using a Paterson-type deformation apparatus at P = 400 MPa confining pressure, temperatures, T, between 750 and 850°C, and reaction durations, t, of 2 - 146 h to calculate the kinetic parameters of dolomite rim growth under isostatic stress conditions. For non-isostatic reaction experiments we applied in addition differential stresses, σ, up to 40 MPa perpendicular to the contact interface at T = 750°C for 4 - 171 h duration, initiating minor inelastic deformation of calcite. The thickness of the resulting dolomite reaction rims increases linearly with the square root of time, indicating a diffusion-controlled reaction. The rims consist of two different textural domains. Granular dolomite grains (≈ 2 -5 μm grain size) form next to calcite and elongated palisade-shaped grains (1-6 μm diameter) grow perpendicular to the magnesite interface. Texture measurements with the electron backscatter diffraction technique indicate that the orientations of dolomite grains are mainly influenced by the orientation of the calcite educt crystal, in particular in the granular rim. To some extent, the texture of dolomite palisades is also influenced by the orientation of magnesite. The thickness of the two individual layers increases with temperature. At 400 MPa isostatic pressure, T = 750°C and t = 29 hours, a 5 μm thick granular dolomite layer and a 7 μm thick palisade-shaped layer evolve. At similar conditions and a differential stress of 30 MPa, the rim thickness remains similar; consequently the effect of non-isostatic stress on dolomite rim growth is negligible. Platinum markers show that the initial calcite-magnesite interface is located between granular and palisade-forming dolomite, indicating that rim growth occurs by counter diffusion of MgO and CaO. Diffusion of MgO across the dolomite reaction rim into calcite forms additionally magnesio-calcite grains with diameters of ≈ 13 - 46 μm, depending on the experimental conditions and increasing with increasing distance to the dolomite boundary. At T = 750°C, t = 29 hours, the thickness of the magnesio-calcite layer is 32 μm (isostatic) - 35 μm (σ = 30 MPa). The experiments indicate that solid-state reaction rim growth of dolomite between calcite and magnesite is primarily controlled by diffusion of MgO and CaO, forming layers with different microstructures during growth into the educt phases. The kinetics of the reaction in the carbonate system are not significantly changed by differential stresses up to 40 MPa. We suggest that volume diffusion is the dominant transport mechanism, which is presumably less affected by non-isostatic stresses than grain boundary diffusion.

  2. Three-dimensional microstructural analysis of human lumber vertebrae using microcomputed tomography in bone metastasis from prostate cancer

    Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. However, the morphological details of bone metastasis of prostate cancer have not been clarified. The trabecular bone structure of bone metastasis from prostate cancer was investigated in three dimensions using microcomputed tomography (micro-CT). A total of 17 cubes of the lumber spine of a 77-year-old man with prostate cancer were excised post mortem: four of them from non-metastatic and the rest from metastatic sites. The samples were measured using micro-CT with a resolution of 23.2 μm and the standard structural indices and degree of anisotropy were computed. After micro-CT measurement, the samples were tested in a destructive manner for the assessment of mechanical properties. Samples from the metastatic sites showed significantly higher values than those from non-metastatic sites for bone volume (BV), bone surface (BS), bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N) (p<0.005). Bone surface density (BS/BV) and trabecular separation (Tb.Sp) were significantly higher in the samples from non-metastatic sites (p<0.001). Samples from metastatic sites showed a more isotropic arrangement of trabecular bone than those from non-metastatic sites. Three-dimensionally reconstructed images depicted several different patterns of sclerotic bone metastasis, and osteolytic appearance was observed in all of them. Structural parameters such as BV/TV were well correlated with the mechanical properties (r=0.899). The present study clarified the trabecular microstructure of bone metastasis from prostate cancer and suggests that both osteolysis and osteogenesis progress while interacting with each other in all phases of bone metastasis. (author)

  3. Iron-Manganese Redox Reactions in Endeavour Crater Rim Apron Rocks

    Ming, D. W.; Mittlefehldt, D. W.; Gellert, R.; Peretyazhko, T.; Clark, B. C.; Morris, R. V.; Yen, A. S.; Arvidson, R. E.; Crumpler, L. S.; Farrand, W. H.; Grant, J. A., III; Jolliff, B. L.; Parker, T. J.; Schroder, C.

    2015-01-01

    The Mars Exploration Rover Opportunity has been exploring Noachian age rocks and outcrops on the rim of the 22 km diameter Endeavour crater since August 2011. The Cape York area is a low-lying rim of Endeavour that contains 3 distinct lithologies: 1) the stratigraphically lowest Matijevic fm of pre-impact lithology, 2) Shoemaker fm of impact breccias, and 3) the stratigraphically highest rim lithology Grasberg fm of post-impact sediments that drape the lower slopes of the rim. The sulfate-rich sediment of the Burns fm lies unconformably over the Grasberg fm. Ca-sulfate veins were discovered in Grasberg fm sediments; the sulfates precipitated from aqueous fluids flowing upward through these materials. Opportunity investigated the chemistry and morphology of outcrops in the Matijevic fm that have Fe(sup 3+)-rich smectite detected by orbital signatures returned by CRISM on MRO. Matijevic fm also contains "boxwork" fractures with chemistry consistent with an Al-rich smectite and veins that appear to be rich in Ca-sulfate. More recently on Cape Tribulation, Opportunity has characterized two S-, Mg- and Mn-rich rich rocks overturned and fractured by the rover's wheels on Cook Haven. Those rocks have been dubbed "Pinnacle Island" and "Stuart Island" and will be referred to as the "Island" rocks. The objectives of this study are to characterize the Fe and Mn contents in the Cape York materials, including the two Island rocks, and to provide a model for Mn mobilization and precipitation. Detailed geochemistry of Endeavour rim rocks is presented in a companion paper. Geochemical trends and elemental associations were obtained from data returned by the Alpha Particle X-ray Spectrometer (APXS) on Opportunity.

  4. Stereochemical Course of the Reaction Catalyzed by RimO, a Radical SAM Methylthiotransferase.

    Landgraf, Bradley J; Booker, Squire J

    2016-03-01

    RimO is a member of the growing radical S-adenosylmethionine (SAM) superfamily of enzymes, which use a reduced [4Fe-4S] cluster to effect reductive cleavage of the 5' C-S bond of SAM to form a 5'-deoxyadenosyl 5'-radical (5'-dA(•)) intermediate. RimO uses this potent oxidant to catalyze the attachment of a methylthio group (-SCH3) to C3 of aspartate 89 of protein S12, one of 21 proteins that compose the 30S subunit of the bacterial ribosome. However, the exact mechanism by which this transformation takes place has remained elusive. Herein, we describe the stereochemical course of the RimO reaction. Using peptide mimics of the S12 protein bearing deuterium at the 3 pro-R or 3 pro-S positions of the target aspartyl residue, we show that RimO from Bacteroides thetaiotaomicron (Bt) catalyzes abstraction of the pro-S hydrogen atom, as evidenced by the transfer of deuterium into 5'-deoxyadenosine (5'-dAH). The observed kinetic isotope effect on H atom versus D atom abstraction is ∼1.9, suggesting that this step is at least partially rate determining. We also demonstrate that Bt RimO can utilize the flavodoxin/flavodoxin oxidoreductase/NADPH reducing system from Escherichia coli as a source of requisite electrons. Use of this in vivo reducing system decreases, but does not eliminate, formation of 5'-dAH in excess of methylthiolated product. PMID:26871608

  5. Rim structure formation and high burnup fuel behavior of large-grained UO2 fuels

    Irradiation-induced fuel microstructural evolution of the sub-divided grain structure, or rim structure, of large-grained UO2 pellets has been examined through detailed PIEs. Besides standard grain size pellets with a grain size range of 9-12 μm, two types of undoped and alumino-silicate doped large-grained pellets with a range of 37-63 μm were irradiated in the Halden heavy water reactor up to a cross-sectional pellet average burnup of 86 GWd/t. The effect of grain size on the rim structure formation was quantitatively evaluated in terms of the average Xe depression in the pellet outside region measured by EPMA, based on its lower sensitivity for Xe enclosed in the coarsened rim bubbles. The Xe depression in the high burnup pellets above 60 GWd/t was proportional to d-0.5-d-1.0 (d: grain size), and the two types of large-grained pellets showed remarkable resistance to the rim structure formation. A high density of dislocations preferentially decorated the as-fabricated grain boundaries and the sub-divided grain structure was localized there. These observations were consistent with our proposed formation mechanism of rim structure, in which tangled dislocation networks are organized into the nuclei for recrystallized or sub-divided grains. In addition to higher resistance to the microstructure change, the large-grained pellets showed a smaller swelling rate at higher burnups and a lower fission gas release during base irradiation

  6. Characterizing Pyroxene Reaction Space in Calcium-Aluminum Rich Inclusions: Oxidation During CAI Rim Formation

    Dyl, K. A.; Young, E. D.

    2009-12-01

    We define the reaction space that controls changes in pyroxene composition in CAIs and Wark-Lovering (WL) rims in an oxidizing solar nebula. Ti-rich pyroxenes in CAIs record a sub-solar oxygen fugacity (Ti3+/Ti4+~1.5). WL rim pyroxenes in the CAI Leoville 144A have a distinctly lower oxidation state.This difference supports WL rim condensation in an environment of increasing O2(g) and Mg(g) (Simon et al. 2005). We used the following phase components to identify four linearly independent reactions (Thompson 1982): diopside, CaTs (Al2Mg-1Si-1), T3 (Ti3+AlMg-1Si-1), T4 (Ti4+Al2Mg-1Si-2), En (MgCa-1), perovskite, O(g), Mg(g), SiO(g), and Ca(g). Compositional variation in this system is dominated by two reactions. The first is oxidation of Ti3+ via reaction with O and Mg in the gas phase: 1.5 O(g) + Mg(g) → ¼ Di + [Ti4+Mg3/4Ti3+-1Ca-1/4Si-1/2] (1). Pyroxene is produced and En is introduced. The second reaction (2) is perovskite formation. It is observed in the WL rim of Leoville 144A, and experiments confirm that an elevated Ti component converts pyroxene to perovskite(Gupta et al. 1973). MgCa-1 is the third linearly independent reaction (3). They combine to give: ½ Di + x Ca(g)→ x Mg(g)+ Pv + [Mg1/2-xSiTi4+-1Ca-1/2+x](2,3). Unlike (1), pyroxene is consumed in this reaction. The parameter x defines the extent of Mg-Ca exchange. When x > 0.5, WL rim formation occurs in an environment where Mg is volatile and Ca condenses. The reaction space defined by reactions (1) and (2,3) describes the transition from CAI interior to WL rims. WL rim pyroxene Ti contents, [CaTs], and Ca < 1 pfu are all explained in this space. The fourth linearly independent reaction is SiO(g):1/8 Di + ¼ Mg(g)→ ¾ SiO(g) + [Mg3/8Ca1/8Ti4+Ti3+-1Si-1/2](4). Silica reduction forms Ti4+, releasing SiO(g). (4) does not describe the oxidation of Ti3+ in WL rim pyroxene, but (1) - (4) results in En formation directly from the gas phase. This may explain WL rim analyses that have Si contents in excess of those predicted from reactions (1) and (2,3). Simon et al. (2005) EPSL 41, 272-283; Thompson (1982)Rev. Min. 10, 33-52; Gupta et al. (1973) Contr. Mineral. Petrol. 41, 333-344 Reaction space for CAI pyroxene. Pyroxenes plotted using titanium contents.

  7. Rim versus Non-Rim States in the Arctic Region: Prospects for a Zero-Sum Game or a Win-Win One?

    Ana-Maria Ghimiş

    2013-09-01

    Full Text Available The present paper aims to develop a critical approach on one of the most urgent energy security challenges: the Arctic region. Until recently, it was considered to be a frozen desert, upon which no one raised any legal demands or interests. The global warming, the technological development and the increased need for energy resources had transformed the frozen High North into a very hot spot, where states like US, Canada, Norway, Denmark or Russia started an energy race that threatens to escalate. The Arctic became a strategic area given its opportunities: besides the energy resources, new commercial routes could become available for a longer period of time. But, due to legal uncertainties, the lack of coherent and direct legal procedures of international law, the Arctic game is an open one, in which any state can intervene and ask for a solution that is suitable for its interests. This aspect complicates even further the already unstable region. Some of the actors see the region as an international area, as a common good, where everyone has the right to explore or exploit, while the rim states see the Arctic in sovereign rights terms. Therefore, the game tends to complicate as non-rim players (the EU, China, Japan, NATO and South Korea want to intervene in the region and try to influence its development.

  8. Solitary myofibroma of the lumbar vertebra: adult case

    Konishi, E.; Yanagisawa, A. [Kyoto Prefectural University of Medicne, Department of Pathology, Kyoto (Japan); Mazaki, T.; Urata, Y. [Kyoto City Hospital, Department of Pathology, Kyoto (Japan); Tanaka, K.; Kanoe, H.; Ikenaga, M. [Kyoto City Hospital, Department of Orthopedic Surgery, Kyoto (Japan); Hayakawa, K. [Kyoto City Hospital, Department of Radiology, Kyoto (Japan)

    2007-06-15

    We present the first known adult case of solitary myofibroma of bone, which affected a lumbar vertebra in a 33-year-old male. Radiography identified a purely lytic lesion with a sclerotic rim in the right pedicle of L1. CT showed an expansile lytic lesion with a sclerotic rim. MRI of the lesion revealed an isointense signal on T1-weighted images, an inhomogeneously hyperintense signal on T2-weighted images, and marked enhancement with gadolinium. Pathological study showed a mixed picture of nodular proliferation of spindle-shaped myoid cells and hemangiopericytomatous proliferation of short spindle/small round cells. The tumor cells were immunoreactive for smooth muscle actin and immunonegative for desmin. This case of solitary myofibroma of bone is exceptionally rare because of its occurrence in an adult older than 20 years of age and its location at an extra-craniofacial site. (orig.)

  9. A study on the influence of calcified intervertebral disk and aorta in determining bone mineral density.

    Cherney, David D; Laymon, Michael S; McNitt, Amy; Yuly, Steve

    2002-01-01

    This study utilized dual-energy X-ray absorptiometry (DXA) to determine the association that age-related calcinosis of the aorta and intervertebral disks have in determining bone mineral density (BMD). Eight cadavers were chosen at random and were scanned with DXA before and after the removal of the aorta and intervertebral disks. Our results showed that the removal of sclerotic aortas decreased the vertebral BMD an average of 4.64% and the removal of two lumbar intervertebral disks further decreased BMD an average of 11.93%. These results were deemed significant at the 0.01 level using a Friedman two-way analysis of variance by ranks. It can be concluded that the presence of aortic arteriosclerotic lesions and intervertebral disk chondrocalcinosis add a significant contribution to BMD. PMID:12110763

  10. A magnetic resonance imaging study on changes in rat mandibular bone marrow and pulp tissue after high-dose irradiation

    Lee, Wan; Lee, Byung Do [Dept. of Oral and Maxillofacial Radiology and Wonkwang Dental Research Institute, College of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Lee, Kang Kyoo [Dept. of Radiation Oncology, School of Medicine, Wonkwang University, Iksan (Korea, Republic of); Koh, Kwang Joon [Dept. of Oral and Maxillofacial Radiology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju (Korea, Republic of)

    2014-03-15

    This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow.

  11. A magnetic resonance imaging study on changes in rat mandibular bone marrow and pulp tissue after high-dose irradiation

    This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow.

  12. [Bone transplant].

    San Julián, M; Valentí, A

    2006-01-01

    We describe the methodology of the Bone and Soft Tissue Bank, from extraction and storage until use. Since the year 1986, with the creation of the Bone Bank in the University Clinic of Navarra, more than 3,000 grafts have been used for very different types of surgery. Bone grafts can be classified into cortical and spongy; the former are principally used in surgery to save tumour patients, in large post-traumatic reconstructions and in replacement surgery where there are massive bone defects and a structural support is required. The spongy grafts are the most used due to their numerous indications; they are especially useful in filling cavities that require a significant quantity of graft when the autograft is insufficient, or as a complement. They are also of special help in treating fractures when there is bone loss and in the treatment of delays in consolidation and pseudoarthrosis in little vascularized and atrophic zones. They are also used in prosthetic surgery against the presence of cavity type defects. Allografts of soft tissues are specially recognised in multiple ligament injuries that require reconstructions. Nowadays, the most utilised are those employed in surgery of the anterior cruciate ligament although they can be used for filling any ligament or tendon defect. The principal difficulties of the cortical allografts are in the consolidation of the ends with the bone itself and in tumour surgery, given that these are patients immunodepressed by the treatment, the incidence of infection is increased with respect to spongy grafts and soft tissues, which is irrelevant. In short, the increasingly widespread use of allografts is an essential therapeutic weapon in orthopaedic surgery and traumatology. It must be used by expert hands. PMID:16998521

  13. The C-terminal Cytosolic Region of Rim21 Senses Alterations in Plasma Membrane Lipid Composition: INSIGHTS INTO SENSING MECHANISMS FOR PLASMA MEMBRANE LIPID ASYMMETRY.

    Nishino, Kanako; Obara, Keisuke; Kihara, Akio

    2015-12-25

    Yeast responds to alterations in plasma membrane lipid asymmetry and external alkalization via the sensor protein Rim21 in the Rim101 pathway. However, the sensing mechanism used by Rim21 remains unclear. Here, we found that the C-terminal cytosolic domain of Rim21 (Rim21C) fused with GFP was associated with the plasma membrane under normal conditions but dissociated upon alterations in lipid asymmetry or external alkalization. This indicates that Rim21C contains a sensor motif. Rim21C contains multiple clusters of charged residues. Among them, three consecutive Glu residues (EEE motif) were essential for Rim21 function and dissociation of Rim21C from the plasma membrane in response to changes in lipid asymmetry. In contrast, positively charged residues adjacent to the EEE motif were required for Rim21C to associate with the membrane. We therefore propose an "antenna hypothesis," in which Rim21C moves to or from the plasma membrane and functions as the sensing mechanism of Rim21. PMID:26527678

  14. Bone lesion biopsy

    Bone biopsy; Biopsy - bone ... needle is gently pushed and twisted into the bone. Once the sample is obtained, the needle is ... sample is sent to a lab for examination. Bone biopsy may also be done under general anesthesia ...

  15. Calcium and bones

    Bone strength and calcium ... calcium (as well as phosphorus) to make healthy bones. Bones are the main storage site of calcium in ... your body does not absorb enough calcium, your bones can get weak or will not grow properly. ...

  16. Broken Bones (For Parents)

    ... for Your Child All About Food Allergies Broken Bones KidsHealth > For Parents > Broken Bones Print A A ... bone fragments in place. When Will a Broken Bone Heal? Fractures heal at different rates, depending upon ...

  17. What causes bone loss?

    ... cause. Other times, bone loss and thin bones run in families. In general, white, elderly women are ... at risk of falling and breaking a bone. Smoking. Men and women who smoke have weaker bones. ...

  18. Broken Bones (For Parents)

    ... a Broken Bone Heal? Preventing Broken Bones The harder kids play, the harder they fall. The fact is, broken bones , or ... in line with one another), it may be harder to tell. Some telltale signs that a bone ...

  19. Raman spectroscopic characterization of the core-rim structure in reaction bonded boron carbide ceramics

    Raman spectroscopy was used to characterize the microstructure of reaction bonded boron carbide ceramics. Compositional and structural gradation in the silicon-doped boron carbide phase (rim), which develops around the parent boron carbide region (core) due to the reaction between silicon and boron carbide, was evaluated using changes in Raman peak position and intensity. Peak shifting and intensity variation from the core to the rim region was attributed to changes in the boron carbide crystal structure based on experimental Raman observations and ab initio calculations reported in literature. The results were consistent with compositional analysis determined by energy dispersive spectroscopy. The Raman analysis revealed the substitution of silicon atoms first into the linear 3-atom chain, and then into icosahedral units of the boron carbide structure. Thus, micro-Raman spectroscopy provided a non-destructive means of identifying the preferential positions of Si atoms in the boron carbide lattice

  20. Raman spectroscopic characterization of the core-rim structure in reaction bonded boron carbide ceramics

    Jannotti, Phillip; Subhash, Ghatu; Zheng, James Q.; Halls, Virginia; Karandikar, Prashant G.; Salamone, S.; Aghajanian, Michael K.

    2015-01-01

    Raman spectroscopy was used to characterize the microstructure of reaction bonded boron carbide ceramics. Compositional and structural gradation in the silicon-doped boron carbide phase (rim), which develops around the parent boron carbide region (core) due to the reaction between silicon and boron carbide, was evaluated using changes in Raman peak position and intensity. Peak shifting and intensity variation from the core to the rim region was attributed to changes in the boron carbide crystal structure based on experimental Raman observations and ab initio calculations reported in literature. The results were consistent with compositional analysis determined by energy dispersive spectroscopy. The Raman analysis revealed the substitution of silicon atoms first into the linear 3-atom chain, and then into icosahedral units of the boron carbide structure. Thus, micro-Raman spectroscopy provided a non-destructive means of identifying the preferential positions of Si atoms in the boron carbide lattice.

  1. Raman spectroscopic characterization of the core-rim structure in reaction bonded boron carbide ceramics

    Jannotti, Phillip; Subhash, Ghatu, E-mail: subhash@ufl.edu [Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611 (United States); Zheng, James Q.; Halls, Virginia [Program Executive Office—Soldier Protection and Individual Equipment, US Army, Fort Belvoir, Virginia 22060 (United States); Karandikar, Prashant G.; Salamone, S.; Aghajanian, Michael K. [M-Cubed Technologies, Inc., Newark, Delaware 19711 (United States)

    2015-01-26

    Raman spectroscopy was used to characterize the microstructure of reaction bonded boron carbide ceramics. Compositional and structural gradation in the silicon-doped boron carbide phase (rim), which develops around the parent boron carbide region (core) due to the reaction between silicon and boron carbide, was evaluated using changes in Raman peak position and intensity. Peak shifting and intensity variation from the core to the rim region was attributed to changes in the boron carbide crystal structure based on experimental Raman observations and ab initio calculations reported in literature. The results were consistent with compositional analysis determined by energy dispersive spectroscopy. The Raman analysis revealed the substitution of silicon atoms first into the linear 3-atom chain, and then into icosahedral units of the boron carbide structure. Thus, micro-Raman spectroscopy provided a non-destructive means of identifying the preferential positions of Si atoms in the boron carbide lattice.

  2. Distribution of skeletal muscle involvement in distal myopathy with rimmed vacuoles

    Distribution of skeletal muscle involvement was studied clinically and by computed tomography (CT) in 6 cases (including 5 sporadic cases) with rimmed vacuolar distal myopathy. Although a predilection for the extensors in the lower leg was noted as stressed so far, there were certain cases without this selectivity. The thigh disclosed a selectivity that the flexors and adductors were severely affected while the m. quadriceps femoris was well preserved. The selectivity in the thigh was still found in the cases without selectivity in the lower leg. The neck flexors were also liable to be involved. In addition, CT revealed no compensatory hypertrophy of the specific muscles which was clearly shown in the thigh of distal muscular dystrophy (Miyoshi). The pattern of skeletal muscle involvement was thought to be a characteristic feature of distal myopathy with rimmed vacuoles. It was visualized very clearly and easily by CT of skeletal muscles although it could be noted to a certain degree by physical examination. (author)

  3. Ammonia observations of bright-rimmed clouds: establishing a sample of triggered protostars

    Morgan, L K; Urquhart, J S; Thompson, M A

    2010-01-01

    We observed 42 molecular condensations within previously identified bright-rimmed clouds in the ammonia rotational inversion lines NH3 (1,1), (2,2), (3,3) and (4,4) using the Green Bank Telescope in Green Bank, West Virginia. Using the relative peaks of the ammonia lines and their hyperfine satellites we have determined important parameters of these clouds, including rotational temperatures and column densities. These observations confirm the presence of dense gas towards IRAS point sources detected at submillimetre wavelengths. Derived physical properties allow us to refine the sample of bright-rimmed clouds into those likely to be sites of star formation, triggered via the process of radiatively-driven implosion. An investigation of the physical properties of our sources show that triggered sources are host to greater turbulent velocity dispersions, likely indicative of shock motions within the cloud material. These may be attributed to the passage of triggered shocks or simply the association of outflow ac...

  4. Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae

    Cameroni Elisabetta

    2006-04-01

    Full Text Available Abstract In recent years, the general understanding of nutrient sensing and signalling, as well as the knowledge about responses triggered by altered nutrient availability have greatly advanced. While initial studies were directed to top-down elucidation of single nutrient-induced pathways, recent investigations place the individual signalling pathways into signalling networks and pursue the identification of converging effector branches that orchestrate the dynamical responses to nutritional cues. In this review, we focus on Rim15, a protein kinase required in yeast for the proper entry into stationary phase (G0. Recent studies revealed that the activity of Rim15 is regulated by the interplay of at least four intercepting nutrient-responsive pathways.

  5. Improved precision and accuracy in quantifying plutonium isotope ratios by RIMS

    Resonance ionization mass spectrometry (RIMS) holds the promise of rapid, isobar-free quantification of actinide isotope ratios in as-received materials (i.e. not chemically purified). Recent progress in achieving this potential using two Pu test materials is presented. RIMS measurements were conducted multiple times over a period of two months on two different Pu solutions deposited on metal surfaces. Measurements were bracketed with a Pu isotopic standard, and yielded absolute accuracies of the measured 240Pu/239Pu ratios of 0.7 and 0.58 %, with precisions (95 % confidence intervals) of 1.49 and 0.91 %. The minor isotope 238Pu was also quantified despite the presence of a significant quantity of 238U in the samples. (author)

  6. Possible rim crest deposits in cores 12027 and 15008 - Some interpretations and problems for future research

    Nagle, J. S.

    1980-01-01

    Light colored coarse grained soils in the upper parts of cores 12027 and 15008 have a chaotic fabric and abundant bedrock-derived rock fragments. They overlie dark colored, fine grained soils with horizontal fabric and abundant regolith-derived rock fragments. The light colored soils are interpreted to be rim crest deposits associated with the craters seen in the lunar surface sampling photographs. The coarse size, poor sorting and chaotic fabric are believed to have originated by the violent mixing processes which are expected with ejecta deposition. The increase in bedrock-derived particles within the light colored soil can be explained by ejecta from craters that penetrated through or deep into the regolith. The dark soils are believed to predate the craters. Distribution of rock fragments in the material interpreted as rim crest ejecta does not fit a simple model of overturned stratigraphy.

  7. Development of SFR Research and Integration Management System (S-RIMS)

    Up to the present, the management of research and development (R and D) for a sodium cooled fast reactor (SFR) could be individually performed on each project without an organic relationship. However, a more systemic and effective integrated management of a project is required because the research and development environment is currently changing. Thus, we developed a Research and Integration Management System for SFR (S-RIMS) based on the enterprise project management (EPM) solution. The functional goals of the S-RIMS are as follows: 1. Provide data that show the progress and status of a project 2. Manage the design process and R and D products 3. Share the consistent design data between sub-projects

  8. XMM-Newton Observations Of The Eastern Rim Of The Vela SNR

    Gaetz, Terrance J.; Edgar, R. J.; Plucinsky, P. P.; Sasaki, M.; Sankrit, R.; Smith, R. K.; Haverkorn, M.; Aschenbach, B.

    2006-09-01

    The Vela Supernova Remnant (SNR) is notable for a number of protrusions extending well beyond the rim. "Fragment D" is the brightest and largest such feature, and it has been found to be strongly enriched in O, Ne, and Mg (Katsuda et al. 2005). The enhanced abundances imply that the feature is indeed a fragment of ejecta from the explosion, but its survival to such a large distance and late time is not well understood. In order to better understand these features, we proposed to observe more of the "Fragment D" region using XMM-Newton. We have recently obtained data for the first of the approved observations, which covers the adjacent bright rim of the supernova remnant. We will report on preliminary analyses of the imaging and spectral data, including the plasma physical conditions and the abundances. This work was supported by NASA contract NAS8-03060.

  9. Resonance ionization mass spectroscopy (RIMS) for nuclear research and trace analysis

    RIMS has been applied to study hyperfine structure and isotope shift of 197Au - 183Au and 198Pt - 183Pt at the on-line isotope separator ISOL-DE, CERN, Geneva. The nuclear shape transition first discovered at 185Hg could be followed up in Au and Pt. RIMS has been applied at Mainz to trace analysis of Pu and Tc with an efficiency of 4-2 x 10-6 and for a laser ion source where Tc atoms are confined in a hot cavity. The latter experiment aims for a determination of the solar neutrino flux from Tc samples extracted out of Mo mines. Finally, the Mainz set-up for trace analysis of 108 atoms of 90Sr in the presence of 1018 stable Sr atoms will be described

  10. Asia/Pacific Rim renewable energy market assessments by the State of Hawaii

    The State of Hawaii has begun to encourage its economic growth and diversification by increasing the export of U.S. energy, environment, ocean, and information technologies. Hawaii's Strategic Technology Market Assessment and Development (STMAD) program promotes the transfer of U.S. technology into Asia and the Pacific Rim, locations having phenomenal growth potential and vast technological infrastructure demands. The STMAD program is managed by the State's Department of Business, Economic Development and Tourism (DBEDT). Under the auspices of STMAD, the Hawaii Natural Energy Institute (HNEI) of the University of Hawaii is assessing biomass energy resources of Asian and Pacific Rim countries to identify and investigate sustainable energy markets. This paper reviews the STMAD program and reports findings of renewable energy assessment performed by HNEI and DBEDT. (author)

  11. The productive efficiency of ports: Lessons from the Pacific Rim Seaport's

    Cheon, SangHyun

    2007-01-01

    This research is to evaluate whether and how global port reform efforts since the early 1990s strongly pursued in many Pacific Rim countries such as Australia, New Zealand, Singapore, China and many other ports in Latin America contribute to higher productivity. The research, as the basis of Mr. SangHyun Cheon's Ph.D. dissertation (the graduate student researcher conducting this research), theoretically aims to understand the ways port institutions, such as port ownership and corporate struct...

  12. Bioclimate-Vegetation Interrelations along the Pacific Rim of North America

    Manuel Peinado; Gustavo Díaz; José Delgadillo; Francisco Manuel Ocaña-Peinado; Miguel Ángel Macías; Juan Luis Aguirre; Alejandro Aparicio

    2012-01-01

    This study was designed to examine relationships between climate and vegetation of the Pacific rim of North America, from the Mediterranean deserts of California to Alaska’s boreal taiga. Relations were inferred from temperature and rainfall data recorded at 457 weather stations and by sampling the vegetation around these stations. Climate data were used to construct climatograms, calculate forty one variables and detect main latitudinal and longitudinal gradients. In order to identify the be...

  13. PRAGMA-ENT: Exposing SDN Concepts to Domain Scientists in the Pacific Rim

    Ichikawa, Kohei; Tsugawa, Mauricio; Haga, Jason; Yamanaka, Hiroaki; Liu, Te-Lung; Kido, Yoshiyuki; U-Chupala, Pongsakorn; Huang, Che; Nakasan, Chawanat; Chang, Jo-Yu; Ku, Li-Chi; Tsai, Whey-Fone; Date, Susumu; Shimojo, Shinji; Papadopoulos, Philip

    2015-01-01

    The Pacific Rim Application and Grid Middleware Assembly (PRAGMA) is an international community of researchers that actively collaborate to address problems and challenges of common interest in eScience. The PRAGMA Experimental Network Testbed (PRAGMA-ENT) was established with the goal of constructing an international software-defined network (SDN) testbed to offer the necessary networking support to the PRAGMA cyberinfrastructure. PRAGMA-ENT is isolated, and PRAGMA researchers have complete ...

  14. Tip gap flow characteristics in a turbine cascade equipped with pressure-side partial squealer rims

    Highlights: • The tip gap flow over pressure-side (PS) squealer tips is investigated. • A schematic tip gap flow model for the PS squealer tip is suggested. • The PS squealer tip has lower aerodynamic loss than the plane tip. - Abstract: Tip gap flow characteristics and aerodynamic loss generations in a turbine cascade equipped with pressure-side partial squealer rims have been investigated with the variation of its rim height-to-span ratio (hp/s) for a tip gap height of h/s = 1.36%. The results show that the tip gap flow is characterized not only by the incoming leakage flow over the pressure-side squealer rim but also by the upstream flow intrusion behind the rim. The incoming leakage flow tends to decelerate through the divergent tip gap flow channel and can hardly reach the blade suction side upstream of the mid-chord, due to the interaction with the upstream flow intrusion as well as due to the flow deceleration. A tip gap flow model has been proposed for hp/s = 3.75%, and the effect of hp/s on the tip surface flow is discussed in detail. With increasing hp/s, the total-pressure loss coefficient mass-averaged all over the present measurement plane decreases steeply, has a minimum value for hp/s = 1.88%, and then increases gradually. Its maximum reduction with respect to the plane tip result is evaluated to be 11.6%, which is found not better than that in the cavity squealer tip case

  15. Determinants and structural development of FDI in Pacific-Rim developing countries

    Agarwal, Jamuna Prasad

    1989-01-01

    The movements of foreign direct investment (FDI) in the recent past are marked by a relatively very high growth in the Pacific Rim (PR) countries (Australia, Brunei, China, Hongkong, Japan, Indonesia, Malaysia, Papua New Guinea, New Zealand, Philippines, Singapore, Taiwan, Thailand). The developing countries of this area were able to raise considerably their share of the total world outflows in the first half of this decade (Table Al) . In the following analysis an attempt is made to work out...

  16. Microstructure, Chemistry, and Origin of Grain Rims on ilmenite from the Lunar Soil Finest Fraction

    Christoffersen, Roy; Keller, Lindsay P.; McKay, David S.

    1996-01-01

    Analytical transmission electron microscope (TEM) observations reveal that ilmenite grains sampled from the sub-10 micron size fraction of Apollo 11 (10084) and Apollo 16 (61221, 67701) soils have rims 10-300 nm thick that are chemically and microstructurally distinct from the host ilmenite. The rims have a thin outer sublayer 10-50 nm thick that contains the ilmenite-incompatible elements Si, Al, Ca and S. This overlies a relatively thicker (50-250 nm) inner sublayer of nanocrystalline Ti-oxide precipitates in a matrix of single-crystal ilmenite that is structurally continuous with the underlying host grain. Microstructural information, as well as data from x-ray spectrometry (EDS) and electron energy loss spectrometry (EELS) analysis of the inner sublayer, suggest that both the inner and outer sublayer assemblages are reduced and that the inner layer is depleted in Fe relative to the underlying ilmenite. The chemistry of the outer sublayer suggests that it is a surface deposit of sputtered or impact-vaporized components from the bulk lunar soil. The inner sublayer is part of the original host grain that has been physically and chemically processed, but not amorphized, by solar ion irradiation and possibly some subsolidus heating. The fact that the deposited outer sublayer is consistently much thinner than the radiation-altered inner sublayer indicates that only a minor fraction of the total rim volume is a product of vapor or sputter deposition. This finding is in contrast to recent descriptions of thick deposited layers on one-third of regolith silicate grains and indicates that ilmenite and silicate rims as a group are different in the fraction of deposited material that they contain.

  17. View of rim of South Ray crater on traverse up Stone Mountain during EVA

    1972-01-01

    A view of the rim of South Ray crater photographed with a 500mm lens from Station no.4 -- the highest point on the traverse up Stone Mountain -- during the second Apollo 16 extravehicular activity (EVA-2) at the Descartes landing site. South Ray crater was a 'fresh' source of angular ejecta in the Lunar Module-Apollo Lunar Surface Experiments Package area and for samples at Station No.8.

  18. Investigations on the performances of the electrical generator of a rim-driven marine current turbine”

    DROUEN, Laurent; Charpentier, Jean-Frederic; SEMAIL, eric; Clenet, Stéphane

    2008-01-01

    In this paper, the electrical generator of a rim-driven horizontal-axis current turbine is modeled in detail. Its main characteristics and performances are evaluated (efficiency, mass, cost, etc). This generator is of permanent magnet direct-driven synchronous type and is connected to a variable speed power electronics drive. It is then compared to a more traditional technology (a pod generator) in terms of mass and cost for a common set of specification. In addition, due to the specific geo...

  19. Favorable outcome of a total hip arthroplasty with insufficient bone coverage of the roof reinforcement ring

    Judas, Fernando M.; Lucas, Francisco M.; Fonseca, Ruben L.

    2015-01-01

    Introduction Total hip arthroplasty in patients with developmental dysplasia of the hip can be a complex procedure due to acetabular and proximal femoral deformities. Presentation of case A 59-year-old male patient underwent a total hip arthroplasty for the treatment of end-stage dysplastic osteoarthritis. A roof reinforcement ring, a cemented polyethylene cup, and a cementless stem were used. A portion of the superior rim of the ring was uncovered by the host bone. Morsellized autogenous femoral-head graft was impacted to fill the space between the superior rim of the ring and the superior part of the dysplastic acetabulum. At the follow-up after 5-years, the patient had no complaints and was very satisfied with the operation result. The hip radiograph revealed no signs of instability of the acetabular component, and no bone graft resorption. Discussion Favorable results were described using metal rings and conical femoral stems for the treatment of the developmental dysplasia of the hip. The superior rim of the metal ring should be against host bone for 60% of its support. Despite the suboptimal implantation of the ring compromising, apparently, mechanical stability of the arthroplasty, the outcome was favorable. Conclusion This result can be supported by the good fixation of the metal ring to the pelvis with screws, the adequate orientation of both components of the total hip arthroplasty, and the bone graft incorporation. PMID:26453941

  20. Energy indicators series: analyzing the energy-related evidence of economic transition in the Pacific Rim

    In recent years, much attention has been focused upon the Asian Pacific countries as constituting an economic 'miracle' over the last two decades. Economic growth in the Pacific Rim has been higher than in any other area of the world. The rapid industrialization process and its impact on the economies of these countries, at both macro and micro levels, are discussed widely in the economic literature. Of particular interest are the fundamental structural changes these countries have experienced in their transition to industrialized economies. This instalment of the annual 'Energy indicators' series concentrates on Pacific Rim countries, namely Hong Kong, the Philippines, Singapore, South Korea, Taiwan and Thailand. Similar to other experiences, rapid economic growth in these countries has been accompanied by 'spectacular' growth in demand for energy. Therefore, this year's paper not only underlines certain trends in these six energy markets but also attempts to test the phenomenon 'threshold country', i.e., shifting from the developing to the industrialized world by using common indicators and methodologies. The analysis starts with a comparison of energy intensities. Section 2 provides an overview of the socio-economic and energy indicators of the Pacific Rim countries. Section 3 introduces a standard econometric model on the most dynamic consuming sector, namely transport. Section 4 presents the projections of consumption in this sector and discusses policy issues. Some concluding remarks in Section 6 complete the paper. (author)

  1. Subciliary Approach for Inferior Orbital Rim Fractures; Case Series and Literature Review

    Seyed Mohammad Motamed al Shariati

    2014-07-01

    Full Text Available Objectives: To report the outcome of subciliary approach for inferior orbital rim fractures in a series of Iranian patients. Methods: This was prospective cross-sectional, being performed during a 12-month period during 2013 in plastic surgery department of Emamreza Hospital of Mashhad. We included 12 patients with traumatic inferior orbital rim fractures who underwent surgical repair through subciliary approach. All the patients were followed for 12 months and were evaluated regarding paresthesia and function as well as presence of a visible scar and lower-eyelid malposition. Results: There were 9 (75.0% men and 3 (25.0% women among the patients with mean age of 26.3±10.6 (range 16-48 years. Of the 12 patients treated with the subciliary approach, 4 (33.3% experienced complications. One (8.3% patient showed 1.5 mm sclera at the end of one year follow-up. No ectropion or entropion was reported in our series. In contrast to 3 (25.0% cases of lower lid visible scar, there was no occurrence of hypertrophic scar. Conclusion: It would be expected that the transorbital approach as it offers good visualization of anterior fractures would result in good outcomes in cases of orbital rim and f loor fracture.

  2. Young stellar population of bright-rimmed clouds BRC 5, BRC 7 and BRC 39

    Panwar, Neelam; Chen, W. P.; Pandey, A. K.; Samal, M. R.; Ogura, K.; Ojha, D. K.; Jose, J.; Bhatt, B. C.

    2014-09-01

    Bright-rimmed clouds (BRCs), illuminated and shaped by nearby OB stars, are potential sites of recent/ongoing star formation. Here we present an optical and infrared photometric study of three BRCs: BRC 5, BRC 7 and BRC 39 to obtain a census of the young stellar population, thereby inferring the star formation scenario, in these regions. In each BRC, the Class I sources are found to be located mostly near the bright rim or inside the cloud, whereas the Class II sources are preferentially outside, with younger sources closer to the rim. This provides strong support to sequential star formation triggered by radiation-driven implosion due to the ultraviolet radiation. Moreover, each BRC contains a small group of young stars being revealed at its head, as the next-generation stars. In particular, the young stars at the heads of BRC 5 and BRC 7 are found to be intermediate-/high-mass stars, which, under proper conditions, may themselves trigger further star birth, thereby propagating star formation out to long distances.

  3. Young Stellar Population of the Bright-Rimmed Clouds BRC 5, BRC 7 and BRC 39

    Panwar, Neelam; Pandey, A K; Samal, M R; Ogura, K; Ojha, D K; Jose, J; Bhatt, B C

    2014-01-01

    Bright-rimmed clouds (BRCs), illuminated and shaped by nearby OB stars, are potential sites of recent/ongoing star formation. Here we present an optical and infrared photometric study of three BRCs: BRC 5, BRC 7 and BRC 39 to obtain a census of the young stellar population, thereby inferring the star formation scenario, in these regions. In each BRC, the Class I sources are found to be located mostly near the bright rim or inside the cloud, whereas the Class II sources are preferentially outside, with younger sources closer to the rim. This provides strong support to sequential star formation triggered by radiation driven implosion due to the UV radiation. Moreover, each BRC contains a small group of young stars being revealed at its head, as the next-generation stars. In particular, the young stars at the heads of BRC 5 and BRC 7 are found to be intermediate/high mass stars, which, under proper conditions, may themselves trigger further star birth, thereby propagating star formation out to long distances.

  4. Influence of stress and strain on dolomite rim growth: a comparative study

    Helpa, V.; Rybacki, E.; Morales, L. F. G.; Dresen, G.

    2015-08-01

    Triaxial compression and torsion experiments were performed to investigate the influence of non-isostatic stress and strain on dolomite reaction rim growth using orientated natural calcite and magnesite single crystals at a temperature of 750 °C, 400 MPa confining pressure, stresses between 7 and 38 MPa, and test durations up to 171 h. Reaction products were composed of a polycrystalline magnesio-calcite layer, palisade-shaped dolomite, and granular dolomite grains. In all experiments, inelastic deformation was partitioned into calcite and reaction products, while magnesite remained undeformed. Calcite deformed by twinning and dislocation creep, where the activation of additional glide systems at high stress allowed high strain. Depending on grain size, magnesio-calcite deformed by diffusion creep and/or grain boundary sliding, twinning, and dislocation creep. Dolomite deformed mainly by diffusion creep, assisted by enhanced dislocation activity allowing Ca enrichment in the granular rim. A weak crystallographic preferred orientation of the reaction products was observed. In triaxial compression, dolomite rim growth was diffusion-controlled and showed no influence of axial stresses up to 38 MPa on the reaction kinetics. At high strain (>0.1), the magnesio-calcite layer is wider suggesting faster growth kinetics. This may be related to additional diffusion pathways provided by enhanced dislocation activity. At very high strain (>0.3-0.6), twisted samples showed a gradual decrease in layer thickness of dolomite and magnesio-calcite with increasing strain (-rate).

  5. Does Oxygen Isotopic Heterogeneity in Refractory Inclusions and Their Wark-Lovering Rims Record Nebular Repressing?

    Simon, J. I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.

    2013-01-01

    Large systematic variations in O-isotopic compositions found within individual mineral layers of rims surrounding Ca-, Al-rich inclusions (CAIs) and at the margins of some CAIs imply formation from distinct environments [e.g., 1-3]. The O-isotope compositions of many CAIs preserve a record of the Solar nebula gas believed to initially be O-16-rich (delta O-17 less than or equal to -25%0) [4-5]. Data from a recent study of the compact Type A Allende CAI, A37, preserve a diffusion profile in the outermost 70 micrometers of the inclusion and show greater than 25%0 variations in delta O-17 within its 100 micrometer-thick Wark-Lovering rim (WL-rim) [3]. This and comparable heterogeneity measured in several other CAIs have been explained by isotopic mixing between the O-16-rich Solar reservoir and a second O-16-poor reservoir (probably nebular gas) with a planetary-like isotopic composition, e.g., [1,2,3,6]. However, there is mineralogical and isotopic evidence from the interiors of CAIs, in particular those from Allende, for parent body alteration. At issue is how to distinguish the record of secondary reprocessing in the nebula from that which occurred on the parent body. We have undertaken the task to study a range of CAI types with varying mineralogies, in part, to address this problem.

  6. The significance of evaluating the craniolateral acetabular rim for hip dysplasia

    The weight-bearing part of the canine hip is its dorsocraniolateral portion. On the radiograph the configuration of the craniolateral acetabular rim is important for evaluation of hip dysplasia. Changes in formation of this area should be differentiated from artefacts due to malpositioning. When the pelvis is tilted dorsally, the cranial acetabular rim is superimposed on the cranioventral acetabular contour and the acetabular roof. The craniolateral contour then seems to be missing. The contours of a ventrally tilted pelvis do not overlap, but it is difficult to discern the craniolateral rim. The reference points for Norberg-Olsson's measurements are difficult to choose in both cases and the angles may vary up to 10 degrees. A symmetrically positioned pelvis shows one point of reference for Norberg-Olsson's measurement where the cranial acetabular contour, the cranioventral margin and the acetabular roof intersect. Therefore poor positioning of the pelvis for radiographic evaluation of hip dysplasia should be avoided when using Norberg-Olsson's measurements

  7. Radiolucent rim as a possible diagnostic aid for differentiating jaw lesions.

    Mortazavi, Hamed; Baharvand, Maryam; Rahmani, Somayeh; Jafari, Soudeh; Parvaei, Parvin

    2015-12-01

    In this study, we formulate a new proposal that complements previous classifications in order to assist dental practitioners in performing a differential diagnosis based on patients' radiographs. We used general search engines and specialized databases such as Google Scholar, PubMed, PubMed Central, MedLine Plus, Science Direct, Scopus, and well-recognized textbooks to find relevant studies by using keywords such as "jaw disease," "jaw lesions," "radiolucent rim," "radiolucent border," and "radiolucent halo." More than 200 articles were found, of which 70 were broadly relevant to the topic. We ultimately included 50 articles that were closely related to the topic of interest. When the relevant data were compiled, the following eight lesions were identified as having a radiolucent rim: periapical cemento-osseous dysplasia, focal cemento-osseous dysplasia, florid cemento-osseous dysplasia, cemento-ossifying fibroma, osteoid osteoma, osteoblastoma, odontoma, and cementoblastoma. We propose a novel subcategory, jaw lesions with a radiolucent rim, which includes eight entities. The implementation of this new category can help improve the diagnoses that dental practitioners make based on patients' radiographs. PMID:26730374

  8. The Abundance Inhomogeneity in the Northern Rim of the Cygnus Loop

    Uchida, Hiroyuki; Katsuda, Satoru; Kimura, Masashi; Kosugi, Hiroko; Takahashi, Hiroaki

    2009-01-01

    We observed the northern rim of the Cygnus Loop with the \\textit{Suzaku} observatory in 5 pointings (P21-P25). From the spatially resolved analysis, all the spectra are well fitted by the single component of the non-equilibrium ionization plasma model. From the best-fit parameters, we found that the abundances of the heavy elements are significantly lower than the solar values except those at the outermost edge in P21 and P22. The origin of the depleted metal abundances is still unclear while such deficiencies have been reported from many other rim observations of the Loop. To explain these depletion at the rim regions, we considered the several possibilities. The effects of the resonance-line-scattering and the grain condensation lower the values of the abundances. However, these are not sufficient to account for the abundance depletion observed. We found that the abundances at the outermost edge in P21 and P22 are higher than those at the other regions. From the morphological point of view, it is reasonable...

  9. Bone scans

    Oftentimes, in managing podiatric complaints, clinical and conventional radiographic techniques are insufficient in determining a patient's problem. This is especially true in the early stages of bone infection. Bone scanning or imaging can provide additional information in the diagnosis of the disorder. However, bone scans are not specific and must be correlated with clinical, radiographic, and laboratory evaluation. In other words, bone scanning does not provide the diagnosis but is an important bit of information aiding in the process of diagnosis. The more useful radionuclides in skeletal imaging are technetium phosphate complexes and gallium citrate. These compounds are administered intravenously and are detected at specific time intervals postinjection by a rectilinear scanner with minification is used and the entire skeleton can be imaged from head to toe. Minification allows visualization of the entire skeleton in a single image. A gamma camera can concentrate on an isolated area. However, it requires multiple views to complete the whole skeletal image. Recent advances have allowed computer augmentation of the data received from radionucleotide imaging. The purpose of this chapter is to present the current radionuclides clinically useful in podiatric patients

  10. Osteoclasts prefer aged bone

    Henriksen, K; Leeming, Diana Julie; Byrjalsen, I; Nielsen, R H; Sorensen, M G; Dziegiel, Morten Hanefeld; Martin, T John; Christiansen, C; Qvist, P; Karsdal, M A

    2007-01-01

    We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of...... aged bones....

  11. MR-guided bone biopsy performed with a new coaxial drill system

    Purpose: To describe the development and clinical evaluation of a new, hand-powered or alternatively motor-driven, MRI and CT compatible percutaneous bone biopsy system. Materials and Methods: A new coaxial drill system (Cook Europe A/S) was designed for percutaneous, MR-guided bone biopsies and powered either by hand or an optional motor (10-250 rotations/minute using 6 bar [88.2 PSI] compressed air). The system has been used in 23 patients. Fourteen procedures were performed in a 1.5 T MR scanner (Philips-Gyroscan ACS-NT) which has an attached C-arm (Philips-BV 212-Angio) in case fluoroscopy is required, and 9 procedures in a CT scanner (Siemens-Somatom Plus). Results: Driven by hand or by the pneumatic motor unit, the system achieved safe and accurate MR-guided access to all of the lesions and was even able to penetrate osteosclerotic lesions. MR- or CT-guided percutaneous biopsy yielded a correct diagnosis in all but 5 cases. No procedural complications occurred. Conclusion: MR-guided percutaneous bone biopsy performed with the new coaxial drill system was found to be safe and reliable, and suitable for obtaining histological specimens from skeletal lesions even when covered with thick cortical or sclerotic bone. (orig.)

  12. Clinical and biologic behavior of bone metastases from differentiated thyroid carcinoma

    Thirty (3.8%) of 780 patients with differentiated thyroid cancer seen between 1970 and 1987 had bone metastases. The primary tumor was follicular in 26 patients and papillary in four. Mean age at diagnosis was 61 years. The manifestation of bone metastases was the presenting symptom in 18 patients (60%). Treatment included total thyroidectomy, levothyroxine sodium therapy, and radioactive iodine treatments. Twenty-seven patients had bone metastases from the initial observation, with 44 sites involved. Of the sites, 27 (61%) were shown both on iodine 131 whole-body scan (WBS) and on x-ray film, 11 (25%) only on WBS, and six (14%) only on x-ray film. Multiple involvement was observed in 11 patients. The radiologic appearance was invariably osteolytic. Serum thyroglobulin was elevated in all patients. After radioactive iodine, no WBS+/X-ray+ metastases showed a complete response, although a sclerotic border was noted in several cases, whereas six WBS+/X-ray- lesions were no longer detectable by WBS. Treatment with radioactive iodine and bone surgery resulted in a complete cure in three patients and in a reduction of tumor mass in three. Twenty-one (70%) of the patients died of thyroid cancer after a mean survival of 86 months. Of the nine patients still alive, two are free of disease, three have a good quality of life, and four have severe disability

  13. Kinematics and thermodynamics of a growing rim of high-pressure phase

    Morris, S. J. S.

    2014-03-01

    We have reanalysed the problem of growth of a dense product rim on a sphere of parent phase. To decouple the problem of calculating deformation from rheology, we assume spherical symmetry, and incompressible phases. Within the product, the radial deviatoric strain and its time-derivative prove to be of opposite sign: strain is compressive, but the strain rate is tensile. Further, the radial deviatoric strain in the new product adjacent to the interface is invariant in time. Propagation of the phase interface is determined by a competition between two mechanisms: as an element of material is transformed, its shear strain energy is increased; and the core pressure performs work compressing it. For elastic phases, this competition results in metastability. Within a certain pressure range, either phase can occur alone, but the two phases can not coexist. Because this result is inconsistent with experiments by Kawazoe et al. (2010) in which a rim of high-pressure phase (wadsleyite) coexists with a central core of low-pressure phase (olivine), we then incorporate plastic flow. Assuming perfect plasticity, we show that for a given applied pressure exceeding the coexistence pressure, a rim of product can now nucleate if the excess pressure Δp exceeds a critical value depending on yield stress. Increasing Δp above this value allows product to grow into the parent phase. There are now two possibilities, depending on the value of Δp. Growth may eventually cease to produce a state in which the product rim is in equilibrium with a parent core; or growth may follow a more complicated path: within a range of excess pressures, the growth rate can decrease strongly from its initial value to produce a quasi-equilibrium state, before increasing again to a rate similar to that at which transformation began. We interpret these results to mean that if Δp is increased slowly in a series of experiments with constant yield stress, the sample passes through a series of equilibria until Δp is large enough for the second type of growth to be possible; transformation is then completed rapidly on the timescale set by interface kinetics. This result may be relevant to the problem of deep earthquakes. Lastly, using existing experiments in which a wadsleyite rim grows on an olivine sphere, we apply the theory to estimate the yield strength of wadsleyite: our estimates are consistent with measurements by independent methods.

  14. Compositions of Diverse Noachian Lithologies at Marathon Valley, Endeavour Crater Rim, Mars

    Mittlefehldt, David W.; Gellert, Ralf; Yen, Albert S.; Ming, Douglas W.; Van Bommel, Scott; Farrand, William H.; Arvidson, Raymond E.; Rice, James W., Jr.

    2015-01-01

    Mars Exploration Rover Opportunity has been exploring Meridiani Planum for 11+ years, and is presently investigating the geology of rim segments of 22 km diameter, Noachian-aged Endeavour crater. The Alpha Particle X-ray Spectrometer has determined the compositions of a pre-impact lithology and impact breccias representing ejecta from the crater. Opportunity is now investigating the head (higher elevation, western end) of Marathon Valley. This valley cuts eastward through the central portion of the Cape Tribulation rim segment and provides a window into the lower stratigraphic record of the rim. At the head of Marathon Valley is a shallow (few 10s of cm), ovoid depression approximately 27×36 m in size, named Spirit of Saint Louis, that is surrounded by approximately 20-30 cm wide zone of more reddish rocks (red zone). Opportunity has just entered a region of Marathon Valley that shows evidence for Fe-Mg smectite in Compact Reconnaissance Imaging Spectrometer for Mars spectra indicating areally extensive and distinct lithologic units and/or styles of aqueous alteration. Rocks at the head of Marathon Valley and within Spirit of Saint Louis are breccias (valley-head rocks). In some areas, layering inside Spirit of Saint Louis appears continuous with the rocks outside. The valley-head rocks are of similar, generally basaltic composition. The continuity in composition, texture and layering suggest the valley-head rocks are coeval breccias, likely from the Endeavour impact. These local breccias are similar in non-volatile-element composition to breccias investigated elsewhere on the rim. Rocks within the red zone are like those on either side in texture, but have higher Al, Si and Ge, and lower S, Mn, Fe, Ni and Zn as compared to rocks on either side. The valley-head rocks have higher S than most Endeavour rim breccias, while red zone rocks are like those latter breccias in S. Patches within the rocks outside Spirit of Saint Louis have higher Al, Si and Ge indicating red-zone-style alteration extended beyond the narrow red zone. Rocks on either side of the red zone and patches within it have the multispectral signature (determined by Panoramic Camera) of red hematite indicating an oxidizing environment. The red zone appears to be a thin alteration zone marking the border of Spirit of Saint Louis, but the origin of this morphologic feature remains obscure.

  15. Chondroblastoma arising in the triradiate cartilage

    Chondroblastoma is a relatively rare benign bone tumor of cartilage origin. Roentgenologically it presents usually as a region of lytic destruction of bone with a thin sclerotic rim in the epiphysis of long tubular bone. Less than 9% occur in the pelvic bones but show a tendency to arise from the triradiate cartilage. We present two cases of chondroblastoma originating in the triradiate cartilage, each showing extensive lytic bony destruction and an intrapelvic soft tissue mass. A review of the literature suggests that chondroblastoma of the triradiate cartilage shows an aggressive radiological appearance. (orig.)

  16. Chondroblastoma arising in the triradiate cartilage. Report of two cases with review of the literature

    Matsuno, Takeo; Hasegawa, Isao; Masuda, Takeshi

    1987-04-01

    Chondroblastoma is a relatively rare benign bone tumor of cartilage origin. Roentgenologically it presents usually as a region of lytic destruction of bone with a thin sclerotic rim in the epiphysis of long tubular bone. Less than 9% occur in the pelvic bones but show a tendency to arise from the triradiate cartilage. We present two cases of chondroblastoma originating in the triradiate cartilage, each showing extensive lytic bony destruction and an intrapelvic soft tissue mass. A review of the literature suggests that chondroblastoma of the triradiate cartilage shows an aggressive radiological appearance.

  17. Nat'l_Register, ContributingResources, The Rim Trail at Pipe Spring National Monument, Arizona (pisp_qrytrail)

    National Park Service, Department of the Interior — This is an Arc/Info coverage consisting of 4 arcs representing the portion of The Rim Trail at Pipe Spring National Monument, Arizona that occurs within the...

  18. RIM1α and Interacting Proteins Involved in Presynaptic Plasticity Mediate Prepulse Inhibition and Additional Behaviors Linked to Schizophrenia

    Blundell, Jacqueline; Kaeser, Pascal S; Südhof, Thomas C.; Powell, Craig M.

    2010-01-01

    Several presynaptic proteins involved in neurotransmitter release in the central nervous system have been implicated in schizophrenia in human clinical genetic studies, in post-mortem studies, and in studies of putative animal models of schizophrenia. The presynaptic protein RIM1α mediates presynaptic plasticity and cognitive function. We now demonstrate that mice deficient in RIM1α exhibit abnormalities in multiple schizophrenia-relevant behavioral tasks including prepulse inhibition, respon...

  19. AoRim15 is involved in conidial stress tolerance, conidiation and sclerotia formation in the filamentous fungus Aspergillus oryzae.

    Nakamura, Hidetoshi; Kikuma, Takashi; Jin, Feng Jie; Maruyama, Jun-Ichi; Kitamoto, Katsuhiko

    2016-04-01

    The serine-threonine kinase Rim15p is a master regulator of stress signaling and is required for stress tolerance and sexual sporulation in the yeast Saccharomyces cerevisiae. However, in filamentous fungi that reproduce asexually via conidiation, the physiological function of Rim15p homologs has not been extensively analyzed. Here, we functionally characterized the protein homolog of Rim15p in the filamentous fungus Aspergillus oryzae, by deleting and overexpressing the corresponding Aorim15 gene and examining the role of this protein in stress tolerance and development. Deletion of Aorim15 resulted in an increase in the sensitivity of conidia to oxidative and heat stresses, whereas conidia of the Aorim15 overexpressing strain were more resistant to these stresses. These results indicated that AoRim15 functions in stress tolerance, similar to S. cerevisiae Rim15p. Phenotypic analysis revealed that conidiation was markedly reduced by overexpression of Aorim15 in A. oryzae, and was completely abolished in the deletion strain. In addition, the formation of sclerotia, which is another type of developmental structure in filamentous fungi, was decreased by the deletion of Aorim15, whereas Aorim15 overexpression increased the number of sclerotia. These results indicated that AoRim15 is a positive regulator of sclerotia formation and that overexpression of AoRim15 shifts the developmental balance from conidiation towards sclerotia formation. Collectively, we demonstrated that AoRim15 is involved in the stress tolerance of conidia and differentially regulates between the two developmental fates of conidiation and sclerotia formation. PMID:26467693

  20. Development of high sensitive and reliable FFD and sodium leak detection technique for fast reactor using RIMS

    The high sensitive fuel failure and sodium leak detection technique for fast reactors has been developed using laser resonance ionization mass spectrometry (RIMS) method. The RIMS is suitable for the isotope analysis of the element of ultra trace level, since there is no increase of the background by interfering ion and isobaric interference except for measuring element, because the measuring element is selectively ionized. The RIMS was applied to measure the artificially blended xenon and krypton gas (tag gas) which is used for the pressurized steel capsule of in-pile creep rupture experiment in the experimental fast reactor Joyo. This system can measure the tag gas isotopic ratios of about 100 ∼ 102 ppb level and the measured results could identify tag gas. The RIMS system can detect stable xenon nuclides and 133Xe in the sample of cover gas which was stored in the stainless steel container during the fuel failure simulation test in Joyo. The result shows the applicability of the RIMS system for assuming the burn-up of the failed fuel subassembly by the ratio of stable and radioactive xenon isotopes. The RIMS is then applied to detect a small amount of sodium leaks from the fast reactor cooling system. In case of detecting sodium isotopes using RIMS, the aerodynamic lens was newly introduced, which can transfer aerosols at atmospheric pressure into a vacuum chamber while increasing the aerosol density at the same time. We performed the experiments using stable isotope 23Na to evaluate the detection sensitivity of the prototype system. The preliminary test results showed that prototype system could easily detect sodium aerosol of 2.7 ppt, of which sensitivity is 400 times higher than the conventional sodium leak detectors currently used. The RIMS system is expected to be a promising innovative instrumentation system not only for Monju, but also for the future sodium cooled fast reactors. (author)

  1. COL1A1 C-propeptide cleavage site mutation causes high bone mass, bone fragility and jaw lesions: a new cause of gnathodiaphyseal dysplasia?

    McInerney-Leo, A M; Duncan, E L; Leo, P J; Gardiner, B; Bradbury, L A; Harris, J E; Clark, G R; Brown, M A; Zankl, A

    2015-07-01

    Gnathodiaphyseal dysplasia (GDD) is a rare autosomal dominant condition characterized by bone fragility, irregular bone mineral density (BMD) and fibro-osseous lesions in the skull and jaw. Mutations in Anoctamin-5 (ANO5) have been identified in some cases. We aimed to identify the causative mutation in a family with features of GDD but no mutation in ANO5, using whole exome capture and massive parallel sequencing (WES). WES of two affected individuals (a mother and son) and the mother's unaffected parents identified a mutation in the C-propeptide cleavage site of COL1A1. Similar mutations have been reported in individuals with osteogenesis imperfecta (OI) and paradoxically increased BMD. C-propeptide cleavage site mutations in COL1A1 may not only cause 'high bone mass OI', but also the clinical features of GDD, specifically irregular sclerotic BMD and fibro-osseous lesions in the skull and jaw. GDD patients negative for ANO5 mutations should be assessed for mutations in type I collagen C-propeptide cleavage sites. PMID:24891183

  2. Bone development.

    Berendsen, Agnes D; Olsen, Bjorn R

    2015-11-01

    The development of the vertebrate skeleton reflects its evolutionary history. Cartilage formation came before biomineralization and a head skeleton evolved before the formation of axial and appendicular skeletal structures. This review describes the processes that result in endochondral and intramembranous ossification, the important roles of growth and transcription factors, and the consequences of mutations in some of the genes involved. Following a summary of the origin of cartilage, muscle, and tendon cell lineages in the axial skeleton, we discuss the role of muscle forces in the formation of skeletal architecture and assembly of musculoskeletal functional units. Finally, ontogenetic patterning of bones in response to mechanical loading is reviewed.This article is part of a Special Issue entitled "Muscle Bone Interactions". PMID:26453494

  3. Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases

    Akira Toriihara

    2015-07-01

    Full Text Available Temporal bone chondroblastoma is an extremely rare benign bone tumor. We encountered two cases showing similar imaging findings on computed tomography (CT, magnetic resonance imaging (MRI, and dual-time-point 18F-fluorodeoxyglucose (18F-FDG positron emission tomography (PET/CT. In both cases, CT images revealed temporal bone defects and sclerotic changes around the tumor. Most parts of the tumor showed low signal intensity on T2- weighted MRI images and non-uniform enhancement on gadolinium contrast-enhanced T1-weighted images. No increase in signal intensity was noted in diffusion-weighted images. Dual-time-point PET/CT showed markedly elevated 18F-FDG uptake, which increased from the early to delayed phase. Nevertheless, immunohistochemical analysis of the resected tumor tissue revealed weak expression of glucose transporter-1 and hexokinase II in both tumors. Temporal bone tumors, showing markedly elevated 18F-FDG uptake, which increases from the early to delayed phase on PET/CT images, may be diagnosed as malignant bone tumors. Therefore, the differential diagnosis should include chondroblastoma in combination with its characteristic findings on CT and MRI.

  4. Gaucher disease: MR evaluation of bone marrow features during treatment with enzyme replacement

    Purpose: Enzyme replacement therapy (ERT) arrests and reverses the hematological and visceral symptoms of adult Gaucher disease, the most frequent lysosomal storage disorder. There are only a few studies available evaluating bone disease during ERT. The aim of this study was to investigate the features of bone marrow (bm) by magnetic resonance imaging (MRI) in these patients during ERT. Materials and Methods: MRI was performed prospectively in thirty adult type I Gaucher patients before and during ERT with a mean follow-up of 3 years. Spin-echo sequences (T1/T2) of the lower extremities were obtained and the reconversion (response) or lack of reconversion (non-response) to fatty marrow during treatment was analyzed. The morphological features of bm involvement, a homogeneous or non-homogeneous distribution of bm changes and focal bone lesions surrounded by a rim of reduced signal intensity (SI), were analyzed. Results: Infiltration of bm by Gaucher cells is characterized by a reduction of Sl on both T1- and T2-weighted sequences. Bone marrow responses were seen in 19 patients (63%) during treatment. Focal bone lesions, surrounded by a rim of reduced Sl, did not respond to ERT and correlated with a non-homogenous distribution of bone involvement and splenectomy. (orig.)

  5. The Enigmatic Bench Unit of Endeavour Crater Rim in Meridiani Planum, Mars

    Ruff, S. W.

    2013-12-01

    For the first 2680 sols of its mission, the Mars Exploration Rover Opportunity traversed across essentially the same rocks: sulfur-rich sandstones known as the Burns formation. On August 8, 2011 Opportunity completed a ~21 km traverse from Victoria crater to the rim of the ~22 km diameter Endeavour crater where it crossed a slightly raised smooth bench unit that surrounds an interior core of higher standing and more rugged terrain on a rim segment named Cape York. As recognized by its distinctive morphologic character evident in orbital images, the inward sloping bench feature is found associated with portions of other segments of the discontinuous raised rim of Endeavour crater. Viewed by Opportunity, it appears as platy, fractured, relatively light-toned outcrop that is fine-grained, lacks hematite concretions and in places hosts veins of Ca- and S-rich composition, likely due to precipitation of gypsum in fractures that cut the bench unit (1). The bench outcrop target named Grasberg included a grind using the Rock Abrasion Tool (RAT) to obtain a cleaner surface for the Alpha Particle X-ray Spectrometer chemistry measurement compared with the initially investigated target named Deadwood. In addition to its greater strength than Burns formation as determined by the RAT grind operation, Grasberg and other examples of the bench unit have lower S, higher Cl and other elemental characteristics that depart from typical Burns formation. Thus the 'Grasberg unit' clearly represents a distinct rock type compared to the Meridiani plains. A second unit makes up the exposed core of the Cape York rim segment. Known as Shoemaker formation, it is composed of breccias that are recognized as a suevite deposit produced from the Endeavour impact event (1). The Shoemaker formation appears to be onlapped by the Grasberg unit with Burns formation onlapping it (1). However, a well-exposed section observed in a wedge-shaped fracture known as Whim Creek on the northeast portion of the Cape York bench clearly presents Grasberg rocks above Burns rocks. Erosion of a plunging synclinal form could explain this apparent inverted relationship, or it reveals that the Grasberg unit is younger than Burns formation. But this latter interpretation implies that Grasberg rocks, which have been observed only at the Endeavour rim, have been stripped off of Burns formation everywhere else. The Grasberg bench unit has recently been encountered in an isthmus setting between two low knobs of presumed Shoemaker formation called Nobbys Head and Sutherland Point just south of Cape York. The isthmus also presents Grasberg as topographically elevated above the Burns formation rocks. Despite its broad, smooth exposure, no remnants of Burns formation have been found on top of Grasberg at this location or anywhere on the Cape York bench. So the stratigraphic relationship between Grasberg and Burns rocks remains enigmatic. At the time of writing, Opportunity is at the edge of Solander Point, another bench feature on the northern tip of a rim segment known as Cape Tribulation. The erosional expression of this example appears different from those examined previously and perhaps offers the best chance to understand stratigraphic relationships. 1. S. W. Squyres et al., Ancient impact and aqueous processes at Endeavour Crater, Mars. Science 336, 570 (2012).

  6. RIMS: An Integrated Mapping and Analysis System with Applications to Earth Sciences and Hydrology

    Proussevitch, A. A.; Glidden, S.; Shiklomanov, A. I.; Lammers, R. B.

    2011-12-01

    A web-based information and computational system for analysis of spatially distributed Earth system, climate, and hydrologic data have been developed. The System allows visualization, data exploration, querying, manipulation and arbitrary calculations with any loaded gridded or vector polygon dataset. The system's acronym, RIMS, stands for its core functionality as a Rapid Integrated Mapping System. The system can be deployed for a Global scale projects as well as for regional hydrology and climatology studies. In particular, the Water Systems Analysis Group of the University of New Hampshire developed the global and regional (Northern Eurasia, pan-Arctic) versions of the system with different map projections and specific data. The system has demonstrated its potential for applications in other fields of Earth sciences and education. The key Web server/client components of the framework include (a) a visualization engine built on Open Source libraries (GDAL, PROJ.4, etc.) that are utilized in a MapServer; (b) multi-level data querying tools built on XML server-client communication protocols that allow downloading map data on-the-fly to a client web browser; and (c) data manipulation and grid cell level calculation tools that mimic desktop GIS software functionality via a web interface. Server side data management of the system is designed around a simple database of dataset metadata facilitating mounting of new data to the system and maintaining existing data in an easy manner. RIMS contains "built-in" river network data that allows for query of upstream areas on-demand which can be used for spatial data aggregation and analysis of sub-basin areas. RIMS is an ongoing effort and currently being used to serve a number of websites hosting a suite of hydrologic, environmental and other GIS data.

  7. Forward modeling of radio imaging (RIM) data with the Comsol RF module

    Li, Yongxing; Smith, Richard S.

    2015-12-01

    Radio imaging method (RIM) is an electromagnetic (EM) tomographic method, which can be applied to image the electrical properties (principally the conductivity) in the plane defined by two boreholes. RIM employs the EM waves at radio frequencies between 100 kHz and 10 MHz, and the manner that these waves propagate around subsurface ore bodies has not been studied thoroughly. We studied the wave propagation using the finite element modeling (FEM) algorithm as implemented in the Comsol RF module. An appropriate element size is quantified by comparing the Comsol modeling results of 6 types of element sizes at 4 frequencies with the analytical solution in the homogeneous whole space. The FEM model data with 5 elements per wavelength have errors less than 5%; 7-8 elements per wavelength provide the errors around 1%; when there are 10 elements per wavelength, the errors are less than 1%. Comparison studies for more complicated models with anomalous conductivity structures show that the Comsol modeling results are consistent with results derived from analytical solutions, finite-difference time-domain methods and integral equations. To illustrate the flexibility of the Comsol method for RIM modeling, we provide an example with two moderately conductive bodies between boreholes. Receiver profiles and a relative variation map show that when the conductive bodies are two wavelengths away from the source, the EM wave attenuation and reflection by the conductive bodies can be observed. The amplitude tomography of the model data reveals that with the SIRT algorithm, the location of the conductive anomalies can be reconstructed successfully, although, some limitations exist such as low resolution, incorrect conductivity estimation, and some artifacts. From our work, we conclude that Comsol modeling is helpful to study radio wave propagation and imaging methods.

  8. High-Resolution H2O Maser Observations toward IRAS Sources in Bright-Rimmed Clouds

    Valdettaro, R.; Migenes, V.; Trinidad, M. A.; Brand, J.; Palla, F.

    2008-03-01

    Bright-rimmed clouds (BRCs) are clouds that have been compressed by an external ionization shock front. We present the first high-resolution VLA observations of 20 of these BRCs in the northern hemisphere. We detected water maser emission from three objects: IRAS 21346+5714 (BRC 36), IRAS 21388+5622 (BRC 37), and IRAS 21445+5712 (BRC 39). The low detection rate supports the evidence that BRCs produce mostly low-luminosity objects, for which maser emission is weak and episodic, and suggests that the embedded sources are in a more advanced evolutionary phase than Class 0 objects.

  9. Search for triggered star formation in the unique bright rimmed cloud 4

    Garmire, Gordon

    2007-09-01

    In order to further our understanding of the radiation driven implosion (RDI) processes and provide an observational feedback to the theoretical modelling of these processes for a wide range of parameters, we propose to search for and study triggered star formation in the highly under-pressured with respect to its ionized boundary layer and one of the smallest among the known cataloged bright rimmed clouds (BRCs), BRC 4. The data and science analyses similar to those applied in our study of the BRC 38 (= IC 1396N) will be employed.

  10. Tumor misto do rim com estrutura de Miosarcoma Mipernefroma e blastema renal em individuo adulto

    A. Penna de Azevedo

    1942-01-01

    Full Text Available O A. descreve um caso de turmor misto do rim, em indivíduo do sexo masculino, com 58 anos de idade. A doença teve evolução lenta, somente sendo suspeitada, quando atingiu a fase final. O exame necroscópico revelou a existência de volumoso tumor do rim direito, apresentando forma bosselada, medindo 19 x 10 x 10 cm e pesando 940 g. A massa tumoral destrói quase completamente a estrutura renal, desta pouca restando reconhecivel. Fora do rim, encontra-se tambem tecido blastomatoso no figado, nos gânglios linfáticos mesentéricos, no peritônio e no epiploon. A estrutura do tumor, observada nos cortes histológicos, é variavel conforme o tecido examinado: no rim hipernefroma; fígado, gãnglios linfáticos, nos nódulos do peritônio e do epiploon, sarcoma mioblástico; em alguns gânglios do mesentério, alem da estrutura de sarcoma mioblástico, existe tecido nefrógeno, representado por formações pouco numerosas, constituidas por túbulos epiteliais, reproduzindo a estrutura de túbulo urinífero. casos desta natureza teem sido referidos com particular raridade, muito se aproximando o caso estudado do descrito por CHEVREL-BODIN e MARUELLE.The A. describes a case of mixed tumor of the kidney in a 58-year-old male individual. The disease underwent a slow evolution, only being suspected when it attained its final stage. The post mortem examination revealed the presence of a bulky tumor of the right kidney, of a bosselated surface, measuring 19 x 10 x 10 cms. and 940 grs. in weigtht. The tumoral mass destroys the whole kidney structure, of which but very little of recognizable tissue is left. Outside the kidney, blastomatous tissue is also met with in the liver, mesenteric lymphatic glands, peritoneum and apiploon. The tumor structura observed on histological section, varies in conformity with the tissue examined: hipernephroma in the kidney; myoblastic sarcoma in the liver, lymphatic glands, nodules of the peritoneum and epiploon; in some mesenteric glands, apart from the myoblasto-sarcomatous structure, there is nephrogenic tissue, represented by infrequent formations made up epithelial tubules reproducing the structure of uriniferous tubules. Cases of such a feature have been reported as being of particular rarity, and the case here studied approaches very much that described by CHEVREL-BODIN and MARUELLE.

  11. Trace analysis of plutonium in environmental samples by resonance ionization mass spectroscopy (RIMS)

    Trace amounts of plutonium in the environment can be detected by resonance ionization mass spectroscopy (RIMS). An atomic beam of plutonium is produced after its chemical separation and deposition on a filament. The atoms are ionized by a three-step excitation using pulsed dye-lasers. The ions are mass-selectively detected in a time-of-flight (TOF) mass spectrometer. With this setup a detection limit of 1·106 atoms of plutonium has been achieved. Furthermore, the isotopic composition can be determined. Different samples, including soil from the Chernobyl area, IAEA-certified sediments from the Mururoa Atoll and urine, have been investigated

  12. Avaliação lectino-histoquímica de fígado e rim de ovinos com fotossensibilização causada por Brachiaria decumbens

    Samay Z.R. Costa

    2013-08-01

    Full Text Available Embora sejam as forrageiras mais importantes para a pecuária de corte (bovinocultura de corte no Brasil, em certas épocas ou condições, Brachiaria spp. podem ser tóxicas e causar surtos de fotossensibilização hepatógena que determinam significativas perdas econômicas. Animais que se alimentam em pastos de Brachiaria spp. comumente apresentam macrófagos espumosos isolados ou agrupados, além de cristais no interior de ductos biliares. Saponinas esteroidais têm sido identificadas nestes cristais e são responsabilizadas por lesar o fígado levando ao acúmulo de filoeritrina. Por vezes, imagens negativas desses cristais podem estar presentes no citoplasma de macrófagos espumosos. A patogênese de formação e o tipo de material armazenado nas células espumosas ainda são desconhecidos. A técnica de lectino-histoquímica visa auxiliar na detecção desses macrófagos e, consequentemente, no diagnóstico, além de identificar quais os resíduos de açúcares específicos que estão presentes no citoplasma das células espumosas. Assim, este trabalho teve por objetivo identificar quais lectinas são mais indicadas na detecção de saponinas esteroidais no fígado e rim de ovinos com fotossensibilização causada por Brachiaria decumbens. Fragmentos de fígado e rim de quinze ovinos, de ambos os sexos e idade variável, oriundos de Conceição do Mato Dentro, Minas Gerais, e um ovino mantido em pastagem livre de Brachiaria spp. foram avaliados pela técnica de lectino-histoquímica. Quatorze lectinas foram utilizadas (Con-A, DBA, SBA, PNA, SJA, RCA-I, UEA-I, WGA, SWGA, GSL, PSA, PHA-L, PHA-E e LCA. Verificou-se que, no fígado de ovinos com fotossensibilização provocada pela ingestão de Brachiaria decumbens, a lectina PNA apresentou especificidade e acentuada reatividade aos macrófagos espumosos, bem como especificidade e leve reatividade aos hepatócitos; a lectina WGA teve especificidade e moderada reatividade aos macrófagos espumosos do fígado e especificidade e leve reatividade aos hepatócitos; e as lectinas SBA, GSL e LCA apresentaram especificidade e moderada reatividade aos macrófagos espumosos, entretanto, não foram específicas para hepatócitos. No rim dos ovinos, a lectina PNA foi a que apresentou maior reatividade. Avaliações lectino-histoquímicas ainda não haviam sido realizadas em fígado e rim de ovinos com fotossensibilização provocada por Brachiaria spp.

  13. Em busca do tradutor: Proust e Mérimée por Mário Quintana.

    Claudia Borges de Faveri; Eleonora Castelli

    2005-01-01

    Este artigo pretende estudar as traduções feitas pelo poeta brasileiro Mário Quintana de Carmen, de Prosper Mérimée e de À sombra das raparigas em flor (À l’ombre des jeunes filles en fleur), de Marcel Proust. Com base na análise das etapas do processo tradutório empreendida por Antoine Berman e na abordagem do “tradutor de carne e osso” de Anthony Pym, busca-se a voz tradutor sem acessar os originais, partindo da premissa de que o texto traduzido é capaz de falar por si só. Enfim, tendo em v...

  14. Technical Efficiency and Port Competition: Revisiting the Bohai Economic Rim, China

    Grace Wang

    2012-12-01

    Full Text Available The Bohai Economic Rim plays an important role in supporting China’s economic growth. For this research, we selected nine main ports in the region to study whether intra-port competition or corporatization would improve efficiency. Using a panel fixed effect model and stochastic frontier model, we found that the technical efficiency of selected ports is significantly influenced by the time of the initial public offering than by regional competition. The results are supportive and encouraging for policy makers to move toward the decentralized port governance in China.

  15. The Abundance Inhomogeneity in the Northern Rim of the Cygnus Loop

    Uchida, Hiroyuki; Tsunemi, Hiroshi; Katsuda, Satoru; Kimura, Masashi; Kosugi, Hiroko; Takahashi, Hiroaki

    2009-01-01

    We observed the northern rim of the Cygnus Loop with the \\textit{Suzaku} observatory in 5 pointings (P21-P25). From the spatially resolved analysis, all the spectra are well fitted by the single component of the non-equilibrium ionization plasma model. From the best-fit parameters, we found that the abundances of the heavy elements are significantly lower than the solar values except those at the outermost edge in P21 and P22. The origin of the depleted metal abundances is still unclear while...

  16. Neutron beam research in the Pacific Rim region - an Australian perspective

    A program of research in neutron scattering was established in Australia in the early 1960's, shortly after the reactor HIFAR commenced full power operation. The program has included elements of regional cooperation from the very early days. A report is given on the present status of australian neutron scattering research, and the activities (including several major new developments) in other Pacific Rim countries are briefly reviewed. Given the increasing sophistication of neutron scattering facilities and techniques, the case for regional cooperation is strongly advocated. 13 refs., 1 tab

  17. Sclerotic atrophic plaques associated with a tattoo

    Al-Dawsari, Najla A; Croke, John; Yaar, Mina

    2014-01-01

    Lichen sclerosus is a chronic inflammatory disease, usually of the anogenital area, that causes intractable itching and soreness. Less commonly, it may have extragenital involvement in 15 to 20% of cases. Lichen sclerosus has been reported at sites of injury as a Koebner phenomenon. We report a case of lichen sclerosus at the site of a tattoo with simultaneous genital involvement.

  18. Deflated rims along the Xiangshui River on the Xiliaohe Plain, Northeast China: A case of active fluvial-aeolian interactions

    Han, Guang; Zhang, Guifang; You, Li; Wang, Yong; Yang, Lin; Yang, Ji; Zhou, Liang; Yuan, Minghuan; Zou, Xueyong; Cheng, Hong

    2016-03-01

    Riverine source-bordering sand dunes, as a result of active fluvial-aeolian interactions, are a pronounced feature on the semiarid Xiliaohe Plain, Northeast China. By means of satellite imagery analysis, and both field survey and observation, this paper presents a new type of riverine source-bordering sand dunes - deflated rims, on the downwind margins of the Xiangshui River. They largely result from the deflation of escarpments on the downwind side of valley by local prevailing winds of NW direction, not from the reworking of point bars on floodplain by wind. In general, a rim is primarily composed of three distinct zones: 1) the upwind frontal escarpment zone with variable plan-form shape, gradient and relief, which is formed by either active lateral erosion by river or significant erosion by wind and transient slope runoff; 2) the deflation zone with gentle slopes of 8-18° and small-scale aeolian bedforms, i.e. ripples of fine sand, ridges of coarse sand; and 3) the downwind dynamic deposition zone with distinctive bedforms with variable superficial texture and slip faces. The sand mass on rims derives overwhelmingly from underlying loose late Quaternary sediments, is sufficient and sustainable by successive retreats of the escarpment, and is gradually transported downwind by pulse motions of bedforms, coupled with high wind events. Essentially, deflated rims are a starting point and the incipient phase of mature riverine dunefields. The superimposed bedforms on rims are fundamentally governed by windflow dynamics, sand sediments and antecedent bedform, exhibiting in turn the manner and intensity of rim development. Consequently, the upwind river valley and downwind deflated rim can jointly stimulate marked wave-like motion of both windflow and aeolian bedforms at different scales, especially when high wind events occur. This study sheds some light on the understanding of the origin and development of riverine source-bordering dunefields, and offers new insights into the mechanisms of fluvial-aeolian interactions on drylands worldwide.

  19. Subperiosteal ganglion associated with Paget's disease of bone

    Tumoral lesions related to Paget's disease may be classified as malignant, benign or pseudotumoral. While sarcomatous degeneration is the most feared complication, awareness of benign and pseudotumoral lesions is essential for assisting in accurate histological interpretation of the biopsy sample, which may avoid unnecessary repeat biopsies. We present the first case of a juxta-articular subperiosteal ganglion associated with Paget's disease, with classic imaging characteristics, especially on CT examination. The well-defined soft tissue mass at the medial aspect of the obturator rim, adjacent to a small fracture in pagetic quadrilateral plate, showed an ossified rim and internal gas lucencies, these being the hallmarks of a juxta-articular subperiosteal ganglion. On MRI, the lesion was of intermediate signal intensity on T1-weighted sequences, increased signal intensity on T2-weighted sequences, with rim enhancement after gadolinium contrast injection and preservation of fatty marrow signal of the underlying pagetic bone. Identification of the entity avoided an unnecessary biopsy or surgical intervention. (orig.)

  20. Bone marrow biopsy

    Biopsy - bone marrow ... A bone marrow biopsy may be done in the health care provider's office or in a hospital. The sample may be taken from the pelvic or breast bone. Sometimes, other areas are used. Marrow is removed ...

  1. Malignant bone tumors

    Clinicoroentgenologic semiotics of malignant bone tumors as well as metastatic bone tumors are presented. Diagnosis of malignant and metastatic bone tumors should be always complex, representing a result of cooperation of a physician, roentgenologist, pathoanatomist

  2. Menopause and Bone Loss

    ... vitamin D • Getting little or no exercise • Smoking cigarettes • Drinking too much alcohol Healthy Bone Osteoporosis Over time, this bone loss can lead to osteopenia (low bone mass) or even osteoporosis, ...

  3. Food and Your Bones

    ... You are here Home » Food and Your Bones Food and Your Bones The food that you eat ... taking multivitamins or supplements . Good-for-Your-Bones Foods Food Nutrient Dairy products such as low-fat ...

  4. Healthy Bones Matter

    ... What else affects bone health? Other things could affect your bones, for example: Smoking. Smoking hurts your bones as well as your heart and lungs. Women who smoke have lower levels of estrogen ( ...

  5. Facts about Broken Bones

    ... las fracturas de huesos Your bones are tough stuff — but even tough stuff can break. Like a wooden pencil, bones will ... that? Get a lot of physical activity, especially stuff like jumping and running. Feed your bones the ...

  6. Smoking and Bone Health

    ... supported by your browser. Home Bone Basics Lifestyle Smoking and Bone Health Publication available in: PDF (61 ... late to adopt new habits for healthy bones. Smoking and Osteoporosis Cigarette smoking was first identified as ...

  7. Age Sequence in Small Clusters Associated with Bright-Rimmed Clouds

    Ogura, Katsuo; Chauhan, Neelam; Pandey, Anil K.; Bhatt, Bhuwan C.; Ojha, Devendra; Itoh, Yoichi

    2007-02-01

    Bright-rimmed clouds (BRCs) found in HII regions are probable sites of triggered star formation due to compression by ionization/shock fronts, and it is hypothesized that star formation proceeds from the exciting star(s) side outward of the HII region (``small-scale sequential star formation''). In order to quantitatively test this hypothesis we undertook BVIc photometry of four BRC aggregates. The amounts of interstellar extinction and reddening for each star were estimated by using JHKs photometry. We then constructed reddening-corrected V/V-Ic color-magnitude diagrams, where the age of each star was derived. All of the stars turned out to be a few tenths to a few Myr old. Although the scatters were large and the numbers of the sample stars are small, we found a clear trend that the stars inside or in the immediate vicinity of the bright rim are younger than those outside it in all four aggregates, confirming the hypothesis in question.

  8. Age Sequence in Small Clusters Associated with Bright-Rimmed Clouds

    Ogura, K; Pandey, A K; Bhatt, B C; Ojha, D; Itoh, Y; Ogura, Katsuo; Chauhan, Neelam; Pandey, Anil K.; Bhatt, Bhuwan C.; Ojha, Devendra; Itoh, Yoichi

    2006-01-01

    Bright-rimmed clouds (BRCs) found in H II regions are probable sites of triggered star formation due to compression by ionization/shock fronts, and it is hypothesized that star formation proceeds from the exciting star(s) side outward of the HII region ("small-scale sequential star formation"). In order to quantitatively testify this hypothesis we undertook BVIc photometry of four BRC aggregates. The amounts of interstellar extinction and reddening for each star have been estimated by using the JHKs photometry. Then we constructed reddening-corrected V/V-Ic color-magnitude diagrams, where the age of each star has been derived. All the stars turned out to be a few tenths to a few Myr old. Although the scatters are large and the numbers of the sample stars are small, we found a clear trend that the stars inside or in the immediate vicinity of the bright rim are younger than those outside it in all the four aggregates, confirming the hypothesis in question.

  9. Rim intratorácico ectópico Thoracic ectopic kidney

    Claudinei Leôncio Beraldo

    2005-04-01

    Full Text Available O rim ectópico intratorácico é uma anomalia rara. De todas as ectopias renais é a mais rara (p = 0,005%. Relata-se um caso de ectopia renal intratorácica em um homem negro de 83 anos, que procurou atendimento médico com quadro clínico compatível com enfisema pulmonar. Foi solicitado radiograma de tórax, que evidenciou uma massa, diagnosticada por tomografia computadorizada como ectopia renal. A maioria dos casos de rim torácico aparece como uma tumoração intratorácica encontrada em radiogramas de tórax solicitados por qualquer outra razão alheia à suspeita dessa anomalia, e não necessita de tratamento específico.Thoracic ectopic kidney is a rare anomaly, the rarest of all renal ectopia types (p = 0.005%. Herein, we describe a case of thoracic ectopic kidney in an 83-year-old black man who, upon seeking medical attention, presented a clinical profile consistent with pulmonary emphysema. A chest X-ray was ordered, and the results showed evidence of a mass, which was then diagnosed (through computed tomography as renal ectopia. The majority of thoracic ectopic kidney cases present as an intrathoracic tumor seen on chest X-rays ordered for reasons other than suspicion of this anomaly and do not require special treatment.

  10. Dinitrogen fixation by exposed communities on the rim of Tikehau atoll (Tuamotu Archipelago, French Polynesia)

    Charpy-Roubaud, C.; Larkum, A. W. D.

    2005-12-01

    Various types of sub-aerially exposed microbial mats, including emergent mats, beach sand, beach rock and Kopara mats, are widespread on the 78 km (25 km2) of rim surrounding the Tikehau atoll lagoon. These mats form laminated accretions or diffuse microbial communities growing under high insolation and temperatures, and are therefore subject to desiccation. Both heterocystous and non-heterocystous cyanobacteria occur in these mats. Using acetylene reduction techniques, nitrogenase activity was observed at all sites over a period of 5 years and was 3-17 times higher during daylight than at night in all communities except for beach rock. 15N2 measurements indicated a molar ratio of acetylene reduction to N2 fixed of 1.6 for all exposed communities. Estimated N2 fixation ranged from 1.44 to 8.0 mg N m-2 day-1 in these exposed communities (mean of 4.66 mg N m-2 day-1) with beachrock showing the highest rates. For the whole reef rim, daily N2 fixation amounted to 98.42 kg N day-1 which represents 28% of the rate of fixation in the entire lagoon (area 400 km2).

  11. Alumina+Silica+/-Germanium Alteration in Smectite-Bearing Marathon Valley, Endeavour Crater Rim, Mars

    Mittlefehldt, D. W.; Gellert, R.; Van Bommel, S.; Arvidson, R. E.; Clark, B. C.; Ming, D. W.; Schroeder, C.; Yen, A. S.; Fox, V. K.; Farrand, W. H.; Jolliff, B. L.

    2016-01-01

    Mars Exploration Rover Opportunity has been exploring Mars for 12+ years, and is presently investigating the geology of a western rim segment of 22 kilometers diameter, Noachian- aged Endeavour crater. The Alpha Particle X-ray Spectrometer has determined the compositions of a pre-impact lithology, the Matijevic fm., and polymict impact breccias ejected from the crater, the Shoemaker fm. Opportunity is now investigating a region named Marathon Valley that cuts southwest-northeast through the central portion of the rim segment and provides a window into the lower stratigraphic record. (Geographic names used here are informal.) At the head of Marathon Valley, referred to here as Upper Marathon Valley, is a shallow, ovoid depression approximately 25×35 millimeters in size, named Spirit of Saint Louis. Layering inside Spirit of Saint Louis appears continuous with the Upper Marathon Valley rocks outside, indicating they are coeval. Spirit of Saint Louis is partly bounded by approximately 10-20 centimeters wide zone containing reddish altered rocks (red zone). Red zones also form prominent curvilinear features in Marathon Valley. Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) spectra provide evidence for a really extensive Fe-Mg smectite in the Marathon Valley region, indicating distinct styles of aqueous alteration. The CRISM detections of smectites are based on metal-OH absorptions at approximately 2.3 and 2.4 micron that are at least two times the background noise level.

  12. Particle Acceleration and Magnetic Fields: Looking at the Northwestern Rim of RCW 86 with Chandra

    Castro, Daniel

    2014-08-01

    Non-thermal X-ray emission has been detected from several young shell-type supernova remnants (SNRs), including RX J1713.7-3946, and Vela Jr. These X-rays are believed to be synchrotron radiation from electrons accelerated to TeV energies at the shocks, interacting with the compressed, and possibly amplified, local magnetic field. Observations of gamma-ray emission from several SNRs in the TeV range confirm that particles are being accelerated to energies approaching the knee of the cosmic ray spectrum in these remnants. However, while it is broadly believed that diffusive shock acceleration (DSA) in SNRs produces the bulk of cosmic rays below 1 PeV, we still lack a detailed understanding of the acceleration process and its effects on the the system, such as magnetic field amplification and modifications to hydrodynamic evolution. I will report on our recent observations of the NW rim of SNR RCW 86 with the Chandra X-ray Observatory. This deep look into this SNR allowed us to constrain the magnitude of the post-shock magnetic field in several different regions of the NW rim, where it is significantly amplified relative to the usual ambient fields expected. I will discuss our analysis in detail and comment on how MFA appears to be related to certain characteristics of the SNR shock.

  13. Characterization/Selection of a Continuous Wave Laser for RIMS Analysis in Nuclear Forensics

    Lau, Sunny; Alves, F.; Karunasiri, G.; Smith, C.; Isselhardt, B.

    2015-03-01

    The effort to implement the technology of resonance ionization mass spectroscopy (RIMS) to problems of nuclear forensics involves the use of multiple lasers to selectively ionize the elements of concern. While current systems incorporate pulsed lasers, we present the results of a feasibility study to determine alternative (Continuous Wave) laser technologies to be employed for analysis of the actinides and fission products of debris from a nuclear detonation. RIMS has the potential to provide rapid isotope ratio quantification of the actinides and important fission products for post detonation nuclear forensics. The current approach to ionize uranium and plutonium uses three Ti-Sapphire pulsed lasers capable of a fundamental wavelength range of 700-1000 nm. In this work, we describe the use of a COTS CW laser to replace one of the pulsed lasers used for the second resonance excitation step of plutonium near 847.282 nm. We characterize the critical laser parameters necessary to achieve high precision isotope ratio measurements including the stability over time of the mean wavelength, bandwidth and spectral mode purity. This far narrower bandwidth laser provides a simpler setup, more robust hardware (greater mobility), and more efficient use of laser irradiance.

  14. SURGICAL SITE INFECTIONS: A STUDY OF INCIDENCE, RISK FACTORS & ANTIMICROBIAL SENSITIVITY AT RIMS, KADAPA, A. P.

    Giridhar

    2015-08-01

    Full Text Available S urgical site infection is the most common complication following surgical procedures. The aim of the study is to determine the incidence, associated risk factors and antimicrobial sensitivity pattern at RIMS, KADAPA. MATERIALS AND METHODS: This is a prospective study carried at surgical wards of RIMS KADAPA from Jan. 2015 to June 2015. All the patients were followed for 30 days for development of surgical site infection. Infected cases were identified u sing CDC, criteria. All the data are expressed in percentage. RESULTS : The overall prevalence of surgical site infection is 19%. The incidence was more common in age group above 40 years. The risk factors associated with SSI are long stay in hospital (14% , abdominal surgeries, long duration of surgery, and diabetes. The most common organism isolated is Staphylococcus aureus (30%. CONCLUSION: Surgical site infection is most common following surgery. Significant determinants are long stay in the ward, abdomi nal surgeries, emergency surgeries and diabetes. Effective infection control measures and good regular surveillance will improve the SSI rate to an acceptable level.

  15. The Refined Shock Velocity of the X-Ray Filaments in the RCW 86 Northeast Rim

    Yamaguchi, Hiroya; Castro, Daniel; Williams, Brian J; Lopez, Laura A; Slane, Patrick O; Smith, Randall K; Petre, Robert

    2016-01-01

    A precise measurement of shock velocities is crucial for constraining the mechanism and efficiency of cosmic-ray (CR) acceleration at supernova remnant (SNR) shock fronts. The northeastern rim of the SNR RCW 86 is thought to be a particularly efficient CR acceleration site, owing to the recent result in which an extremely high shock velocity of ~6000 km/s was claimed (Helder et al. 2009). Here we revisit the same SNR rim with the Chandra X-ray Observatory, 11 years after the first observation. This longer baseline than previously available allows us to determine a more accurate proper motion of the nonthermal X-ray filament, revealing a much lower velocity of 3000 \\pm 340 km/s (and even slower at a brighter region). Although the value has dropped to a half of that from the previous X-ray measurement, it is still higher than the mean velocity of the H-alpha filaments in this region (~1200 km/s). This discrepancy implies that the filaments bright in nonthermal X-rays and H-alpha emission trace different velocit...

  16. Definition imaging of an orebody with the radio imaging method (RIM)

    Waste rock dilution is an economic concern in the planning and design of mining methods for mineralized ore zones. Diamond core drilling and mineralogical examination of core are routinely used to determine the general shape of the ore body. Drilling on closer centers enhances the definition of the mineralization and oregrade across the orebody. In a practical sense, drilling time and cost limit definition. Crosshole scanning between drillholes with the radio imaging method (RIM) has been used to map changes in mineralization in the rock mass. The magnitude and phase of the RIM radio wave depend on the electrical conductivity of the rock mass. The conductivity strongly depends on the percent mineralization. Since the attenuation rate and phase constants of the radio wave are proportional to the one half power of conductivity, the measured crosshole radio wave data can be processed in a tomography algorithm to reconstruct images (map the change in conductivity (mineralization)). The tomography image enhances definition in the orebody while reducing the number of drillholes. This paper compares reconstructed images of the radio wave propagation constants to percent mineralization in the ore body

  17. Analysis of physical processes affecting restructuring of UO2 fuel in Rim-zone

    The purpose of the presented paper is the analysis of the processes affecting so-called 'rim-zone' formation in UO2 and the development of the model describing isotope content profiles at extended burnup. The influence of rim-zone and extended burnup on fuel temperatures is also considered. A brief review of the worldwide models for fission rate and isotope content profiles at extended burnup is given. In this frame, a new model for for prediction of radial profiles of burnup, fission rate and plutonium isotopes have been developed in the TRINITY (Russia). The results from the comparison of the model predictions with experimental data show that the model has good predictability. A new model describing the conditions of dislocation loop nucleation from interstitial atom clusters on fission spikes is also proposed in this paper. The results of the model show that the fuel grain diameter significantly affects the concentration of point defects and dislocation loops. The paper presents the results from the RTOP code calculations of fuel temperature, taking into account non-uniform fission rate and thermal conductivity degradation as result of burnup increasing

  18. Anorexia Nervosa and Bone

    Misra, Madhusmita; Klibanski, Anne

    2014-01-01

    Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone mass, impaired bone structure and reduced bone strength, all of which contribute to increased fracture risk., Adolescents with AN have decreased rates of bone accrual compared with normal-weight controls, raising addition concerns of suboptimal peak bone mass and future bone health in this age group. Changes in lean mass and compartmental fat depots, hormonal alterations secondary to nutritional factors...

  19. Evaluation of radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT

    The aim of the study was to retrospectively evaluate radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT and determine their roles on the evaluation of therapy response. We retrospectively evaluated radiographic and metabolic characteristics of bone metastases in 30 patients who were referred for the evaluation of response to systemic therapy with 18FDG-PET/CT. All patients underwent integrated 18FDG-PET/CT before and after treatment. The baseline radiographic patterns of the target lesions in responders group were lytic, sclerotic, mixed and CT negative; after treatment the radiographic patterns of all target lesions changed to a sclerotic pattern and attenuation increased (p = 0.012) and metabolic activity decreased (p = 0.012). A correlation was found between decreasing metabolic activity and increasing attenuation of the target lesions (r = −0.55) (p = 0.026). However, in nonresponders group, the baseline radiologic patterns of the target lesions were lytic, blastic, mixed and CT negative; after treatment all lytic target lesions remained the same and one CT negative lesion turned to lytic pattern and the attenuation of the target lesions decreased (p ± 0.12) and metabolic activity increased (p = 0.012). A correlation was found between increasing metabolic activity and decreasing attenuation (r = −0.65) (p = 0.032). An exception of this rule was seen in baseline blastic metastases which progressed with increasing in size, metabolic activity and attenuation. This study shows that the metabolic activity of lesions is a more reliable parameter than the radiographic patterns for the evaluation of therapy response

  20. Bone strength: more than just bone density.

    Ott, Susan M

    2016-01-01

    The following bone density measurements have limited utility in determining bone strength because they do not include bone quality: microarchitecture, mineralization, ability to repair damage, collagen structure, crystal size, or marrow composition. Patients with kidney disease have poor bone quality. Newman et al. now describe beneficial effects with raloxifene in an animal model of progressive kidney disease. These biomechanical measurements will be important in the development of medications to decrease fractures in patients. PMID:26759040

  1. Paget's sarcoma of bone

    The most sinister complication of Paget's disease is malignant degeneration. The true etiology of Paget's disease remains unproven and unknown. The relative incidence of sarcoma ranges from 0.9% to 20% depending upon the population source. The anatomical distribution of lesions is similar to that of uncomplicated Paget's disease except for the high incidence in the humerus and rare occurrence in the spine. Approximately 50% of the lesions histologically represent osteosarcomas, with fibrosarcoma, fibrous histiocytoma, chondrosarcoma and giant cell tumor rarely occurring. The radiographic presentation is most commonly lytic, but sclerotic and mixed patterns occur. Cortical destruction and soft tissue mass are the cardinal radiographic signs. Malignant periosteal response is seldom found associated with Paget's sarcoma. The most common sites are femur, humerus, pelvis, skull and tibia. The prognosis is fatal at a very rapid rate. There are but a few isolated cases of long-term survival reported. (orig.)

  2. The CT flare response of metastatic bone disease in prostate cancer

    Background New or worsening bone lesions in patients responding to treatment, known as the flare phenomenon is well described on 99mTc-MDP bone scintigraphy, but to our knowledge has not previously been described on CT. The appearance of new or worsening bone sclerosis on CT in patients with prostate cancer may therefore be erroneously classified as disease progression. Purpose To assess the incidence of osteoblastic healing flare response at 3-month CT assessment in patients with castrate-resistant prostate cancer and to identify associated features that enable differentiation from progressive metastatic bone disease at 3 months. Material and Methods CT scans of 67 patients with castrate-resistant prostate cancer undergoing treatment were reviewed by a radiologist blinded to clinical outcome. Changes in number, size, and density of metastatic bone lesions were documented and Response Evaluation Criteria in Solid Tumours (RECIST) in soft tissue lesions, alkaline phosphatase, prostate specific antigen, and 99mTc-MDP bone scans were used for correlation. Results Of the 39 patients who had 3- and 6-month follow-up, eight patients (21%) demonstrated an increase in number, size, or density of sclerotic lesions on the 3-month CT scan despite improvement in PSA and soft tissue lesions. Three out of eight patients (8%) maintained partial response/remained stable at follow-up and were defined as showing a flare response: in this group bone metastases evident on CT showed a qualitative and quantitative increase in density and no lesions faded at 3 months. In contrast, in all patients who progressed at 3 months by PSA/RECIST criteria (n = 8) bone lesions showed a mixed pattern with some lesions increasing and others decreasing in density. Conclusion The incidence of flare response of metastatic bone disease evident at 3-month post-treatment CT in patients with prostate cancer undergoing systemic treatment is 8%. In patients with falling PSA and stable/responding soft tissue disease at 3 months an increase in bone sclerosis in the absence of fading bone metastases can be interpreted as flare and is likely to represent a response

  3. The CT flare response of metastatic bone disease in prostate cancer

    Messiou, Christina; deSouza, Nandita M. (Cancer Research UK Clinical Magnetic Resonance Research Group, Inst. of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey (United Kingdom)), email: Christina.Messiou@icr.ac.uk; Cook, Gary (Dept. of Nuclear Medicine, Royal Marsden NHS Foundation Trust, Surrey (United Kingdom)); Reid, Alison H.M.; Attard, Gerhardt; Dearnaley, David; deBono, Johann S. (Inst. of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey (United Kingdom))

    2011-06-15

    Background New or worsening bone lesions in patients responding to treatment, known as the flare phenomenon is well described on 99mTc-MDP bone scintigraphy, but to our knowledge has not previously been described on CT. The appearance of new or worsening bone sclerosis on CT in patients with prostate cancer may therefore be erroneously classified as disease progression. Purpose To assess the incidence of osteoblastic healing flare response at 3-month CT assessment in patients with castrate-resistant prostate cancer and to identify associated features that enable differentiation from progressive metastatic bone disease at 3 months. Material and Methods CT scans of 67 patients with castrate-resistant prostate cancer undergoing treatment were reviewed by a radiologist blinded to clinical outcome. Changes in number, size, and density of metastatic bone lesions were documented and Response Evaluation Criteria in Solid Tumours (RECIST) in soft tissue lesions, alkaline phosphatase, prostate specific antigen, and 99mTc-MDP bone scans were used for correlation. Results Of the 39 patients who had 3- and 6-month follow-up, eight patients (21%) demonstrated an increase in number, size, or density of sclerotic lesions on the 3-month CT scan despite improvement in PSA and soft tissue lesions. Three out of eight patients (8%) maintained partial response/remained stable at follow-up and were defined as showing a flare response: in this group bone metastases evident on CT showed a qualitative and quantitative increase in density and no lesions faded at 3 months. In contrast, in all patients who progressed at 3 months by PSA/RECIST criteria (n = 8) bone lesions showed a mixed pattern with some lesions increasing and others decreasing in density. Conclusion The incidence of flare response of metastatic bone disease evident at 3-month post-treatment CT in patients with prostate cancer undergoing systemic treatment is 8%. In patients with falling PSA and stable/responding soft tissue disease at 3 months an increase in bone sclerosis in the absence of fading bone metastases can be interpreted as flare and is likely to represent a response

  4. Long-term bone tissue reaction to polyethylene oxide/polybutylene terephthalate copolymer (Polyactive) in metacarpophalangeal joint reconstruction.

    Waris, Eero; Ashammakhi, Nureddin; Lehtimäki, Mauri; Tulamo, Riitta-Mari; Törmälä, Pertti; Kellomäki, Minna; Konttinen, Yrjö T

    2008-06-01

    The poly-L/D-lactide 96/4 joint scaffolds are used to engineer fibrous tissue joints in situ for the reconstruction of metacarpophalangeal joints. In this experimental study, a supplementary elastomeric stem made of Polyactive 1000PEO70PBT30 (a segmented block copolymer of polyethylene oxide and polybutylene terephtalate with 70/30 PEO/PBT ratio) was used to anchor the joint scaffold in the arthroplasty space. Eleven resected fifth metacarpophalangeal joints of minipig were reconstructed and evaluated radiologically and histologically for 3 years. Plain joint scaffold and Swanson silicone implant arthroplasties (11 of each) in metacarpophalangeal joints of minipig served as controls. Altogether fore limbs of eighteen minipigs were operated for the study. Deleterious tissue reaction with dramatic signs of osteolysis and inflammatory foreign-body reaction was observed around the Polyactive stems. The mean maximum diameter of the osteolytic stem cavity was statistically wider when compared to the mean maximum diameter of Swanson implant group during the first postoperative year. Numerous osteoclasts were found at the margins of the osteolytic areas. No direct bone contact could be seen. At 1 year osteoblastic regeneration and formation of new trabecular bone followed. Finally the foreign-body reaction settled, but the adjoining bones were at this stage highly sclerotic and composed of coarse trabeculae. In contrary to previous in vivo studies suggesting biocompatibility, osteoconductivity and capability to bond to bone, Polyactive 1000PEO70PBT30 stem in this setting caused massive osteolytic lesions and foreign-body reactions. PMID:18336902

  5. Exercise, lifestyle, and your bones

    Osteoporosis - exercise; Low bone density - exercise ... Osteoporosis is a disease that causes bones to become brittle and more likely to fracture (break). With osteoporosis, the bones lose density. Bone density is the amount of bone ...

  6. Immediate impact on the rim zone of cement based materials due to chemical attack

    Cement based materials are in their widespread application fields exposed to various aqueous environments. This can lead to serious chemical changes affecting the durability of the materials. In particular in the context of service life prediction a detailed knowledge of the reaction mechanisms is a necessary base for the evaluation of the aggressivity of an aqueous medium and this is deduced commonly from long term investigations. However, these processes start immediately at the material/water-interface, when a cementitious system comes into contact with an aqueous solution, altering here the chemical composition and microstructure. This rim zone represents the first hurdle that has to be overcome by an attacking aqueous solution. Therefore, the properties of the surface near area should be closely associated with the further course of deterioration processes by reactive transport. In this context short term exposure experiments with hardened cement paste over 4 and 48 h have been carried out with demineralized water, hard tap water and different sulfate solutions. In order to investigate immediate changes in the near-surface region, depth profile cuts have been performed on the cement paste samples by means of focused ion beam preparation techniques. A scanning beam of Gallium ions is applied to cut a sharp edge in the cement paste surface, providing insights into the composition and microstructure of the upper ten to hundred microns. Electron microscopic investigations on such a section of the rim zone, together with surface sensitive X-ray diffraction accompanied by a detailed characterization of the bulk composition confirm that the properties of the material/water interface are of relevance for the durability of cement based systems in contact with aqueous solutions. In this manner, focused ion beam investigations constitute auspicious tools to contribute to a more sophisticated understanding of the reaction mechanisms. - Highlights: • The chemical stability is related to the properties of material/water interface. • Properties of the rim zone readjust quickly, triggered by hydrochemical conditions. • Durability research can be improved by combining FIB techniques and common analytics

  7. Evaluation of tsunami potential based on conditional probability for specific zones of the Pacific tsunamigenic rim

    Koravos, George Ch.; Yadav, R. B. S.; Tsapanos, Theodoros M.

    2015-09-01

    The Pacific tsunamigenic rim is one of the most tsunamigenic regions of the world which has experienced large catastrophic tsunamis in the past, resulting in huge loss of lives and properties. In this study, probabilities of occurrences of large tsunamis with tsunami intensity (Soloviev-Imamura intensity scale) I ? 1.5, I ? 2.0, I ? 2.5, I ? 3.0, I ? 3.5 and I ? 4.0 have been calculated over the next 100 years in ten main tsunamigenic zones of the Pacific rim area using a homogeneous and complete tsunami catalogue covering the time periods from 684 to 2011. In order to evaluate tsunami potential, we applied the conditional probability method in each zone by considering the inter-occurrence times between the successive tsunamis generated in the past that follow the lognormal distribution. Thus, we assessed the probability of the next generation of large tsunamis in each zone by considering the time of the last tsunami occurrence. The a-posteriori occurrence of the last large tsunami has been also assessed, assuming that the time of the last occurrence coincides with the time of the event prior to the last one. The estimated a-posteriori probabilities exhibit satisfactory results in most of the zones, revealing a promising technique and confirming the reliability of the tsunami data used. Furthermore, the tsunami potential in different tsunamigenic zones is also expressed in terms of spatial maps of conditional probabilities for two levels of tsunami intensities I ? 1.5 and I ? 2.5 during next 10, 20, 50 and 100 years. Estimated results reveal that the conditional probabilities in the South America and Alaska-Aleutian zones for larger tsunami intensity I ? 2.5 are in the range of 92-93%, much larger than the Japan (69%), for a time period of 100 years, suggesting that those are the most vulnerable tsunamigenic zones. The spatial maps provide brief atlas of tsunami potential in the Pacific rim area.

  8. TRIGGERED STAR FORMATION AND YOUNG STELLAR POPULATION IN BRIGHT-RIMMED CLOUD SFO 38

    We have investigated the young stellar population in and around SFO 38, one of the massive globules located in the northern part of the Galactic H II region IC 1396, using the Spitzer IRAC and MIPS observations (3.6-24 ?m), and followed up with ground-based optical photometric and spectroscopic observations. Based on the IRAC and MIPS colors and H? emission, we identify ?45 young stellar objects (Classes 0/I/II) and 13 probable pre-main-sequence candidates. We derive the spectral types (mostly K- and M-type stars), effective temperatures, and individual extinction of the relatively bright and optically visible Class II objects. Most of the Class II objects show variable H? emission as well as optical and near-infrared photometric variability, which confirm their 'youth'. Based on optical photometry and theoretical isochrones, we estimate the spread in stellar ages to be between 1 and 8 Myr with a median age of 3 Myr and a mass distribution of 0.3-2.2 Msun with a median value around 0.5 Msun. Using the width of the H? emission line measured at 10% peak intensity, we derive the mass accretion rates of individual objects to be between 10-10 and 10-8 Msun yr-1. From the continuum-subtracted H? line image, we find that the H? emission of the globule is not spatially symmetric with respect to the O-type ionizing star HD 206267, and the interstellar extinction toward the globule is also anomalous. We clearly detect an enhanced concentration of YSOs closer to the southern rim of SFO 38 and identify an evolutionary sequence of YSOs from the rim to the dense core of the cloud, with most of the Class II objects located at the bright rim. The YSOs appear to be aligned along two different directions toward the O6.5V type star HD 206267 and the B0V type star HD 206773. This is consistent with the Radiation Driven Implosion (RDI) model for triggered star formation. Further, the apparent speed of sequential star formation is consistent with the speed of propagation of shocks in dense globules as derived from numerical simulations of RDI.

  9. Investigations into the value of bone scintigrams in fracture of the navicular bone. Untersuchungen zur Wertigkeit des Knochenszintigramms bei der Fraktur des Os naviculare

    Schumm, G.

    1985-05-14

    The diagnostic value of bone scintigrams was investigated in a group of 22 patients showing fractured navicular bones and contrasted with that of X-ray pictures and clinical evaluations. The changes revealed by radiology were pseudarthrosis (9 patients), complete fracture (10 patients) as well as cysts and sclerotic processes (3 patients). Eight out of 9 cases of pseudarthrosis, 6 of the 10 complete fractures and 2 of the 3 cysts were confirmed by corresponding pathological changes in the scintigrams. The X-ray pictures and clinical evaluations led to consistent results in 14 patients, conformity of the scintigrams and clinical findings was seen in 17 cases and of the X-ray pictures and scintigrams in 15 cases. The results of the study give evidence of the fact that scintigrams recorded after injection of 99 mTc MDP are primarily suitable to diagnose incipient pathological changes in the tissue adjacent to the fracture. Their use is justified in discrepancies between the clinical and radiological findings or in cases, where conventional X-rays yielded doubtful results as to the therapeutic strategy or incapacitation of the patient. (TRV).

  10. Crack initiation in hydro power plant rotor rim sheets : A failure case study for Juktan hydro power plant

    Altzar, Oskar

    2014-01-01

    In 2013, cracks were found in the radius of the dovetail slots of the rotor rim sheets in generator 1 of Juktan hydro power plant in Västerbotten, Sweden. The cracks were estimated to be too deep to be able to repair and Alstom conducted an investigation on the cause of fracture. The investigation came to the conclusion that the radius was too small and that the new rotor rim sheets should have a six times greater fillet radius. However, it has not been investigated whether the material struc...

  11. Rough Design of a Double-Stator Axial Flux Permanent Magnet Generator for a Rim-Driven Marine Current Turbine

    DJEBARRI, Sofiane; Charpentier, Jean-Frederic; SCUILLER, Franck; BENBOUZID, Mohamed; Guemard, Sylvain

    2012-01-01

    This paper deals with the rough design of a Double-Stator Axial Flux Permanent Magnet Machine (DSAFPM) for a rim-driven Marine Current Turbine (MCT). The DSAFPM machine will be compared to a previously developed and realized Radial Flux Permanent Magnet Machine (RFPM); given the same rim-driven MCT specifications. For that purpose, a first-order electromagnetic design model and a thermal one are developed and used to compare active part mass, cost, and thermal behavior of the two machines. Th...

  12. Bone grafting: An overview

    D. O. Joshi

    2010-08-01

    Full Text Available Bone grafting is the process by which bone is transferred from a source (donor to site (recipient. Due to trauma from accidents by speedy vehicles, falling down from height or gunshot injury particularly in human being, acquired or developmental diseases like rickets, congenital defects like abnormal bone development, wearing out because of age and overuse; lead to bone loss and to replace the loss we need the bone grafting. Osteogenesis, osteoinduction, osteoconduction, mechanical supports are the four basic mechanisms of bone graft. Bone graft can be harvested from the iliac crest, proximal tibia, proximal humerus, proximal femur, ribs and sternum. An ideal bone graft material is biologically inert, source of osteogenic, act as a mechanical support, readily available, easily adaptable in terms of size, shape, length and replaced by the host bone. Except blood, bone is grafted with greater frequency. Bone graft indicated for variety of orthopedic abnormalities, comminuted fractures, delayed unions, non-unions, arthrodesis and osteomyelitis. Bone graft can be harvested from the iliac crest, proximal tibia, proximal humerus, proximal femur, ribs and sternum. By adopting different procedure of graft preservation its antigenicity can be minimized. The concept of bone banking for obtaining bone grafts and implants is very useful for clinical application. Absolute stability require for successful incorporation. Ideal bone graft must possess osteogenic, osteoinductive and osteocon-ductive properties. Cancellous bone graft is superior to cortical bone graft. Usually autologous cancellous bone graft are used as fresh grafts where as allografts are employed as an alloimplant. None of the available type of bone grafts possesses all these properties therefore, a single type of graft cannot be recomm-ended for all types of orthopedic abnormalities. Bone grafts and implants can be selected as per clinical problems, the equipments available and preference of the surgeon. A search for ideal bone graft is on and may continue till time to time. [Vet World 2010; 3(4.000: 198-200

  13. Bone Marrow Transplantation

    Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The ... platelets, which help the blood to clot. A bone marrow transplant is a procedure that replaces a ...

  14. Bone Marrow Diseases

    Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains stem cells. The stem cells can ... the platelets that help with blood clotting. With bone marrow disease, there are problems with the stem ...

  15. Bone grafts in dentistry

    Prasanna Kumar

    2013-01-01

    Full Text Available Bone grafts are used as a filler and scaffold to facilitate bone formation and promote wound healing. These grafts are bioresorbable and have no antigen-antibody reaction. These bone grafts act as a mineral reservoir which induces new bone formation.

  16. Study of triggered star formation in a bright-rimmed cloud

    Ortega, M. E.; Paron, S.; Giacani, E.; Petriella, A.

    2014-10-01

    Bright-rimmed clouds (BRCs) are small and dense molecular clouds located in the periphery of the evolved HII regions. The illumination of these dark clumps by nearby OB stars might be responsible for triggered collapse and subsequent star formation through the mechanism known as radiation-driven implosion (RDI). We carried out a multi-wavelength study of a BRC located in the periphery of the evolved HII region G52.85-0.55. From the evaluation of the pressure balance between the ionized gas located at the illuminated border of the clump and the molecular gas, we show that shocks are being driven in the external layers of the BRC. On the other hand the pressure balance suggests that the birth of young stellar objects embedded in the BRC could have been initiated by the RDI mechanism.

  17. Numerical Simulation of Stresses in Thin-rimmed Spur Gears with Keyway

    B. Brůžek

    2003-01-01

    Full Text Available This paper contains an investigation of the key on a stress distribution in a thin-rimmed spur gear. A stress analysis was carried out by means of the Finite Element Method (FEM. The 2D-FE analysis has helped to find the influence of turning the gearing towards the keyway on the stress in the loaded root of the tooth and in the keyway. 2D and 3D numerical analysis has been used to find mutual influence of every single notch (root of tooth and keyway, influence of thickness of the hub, length of the key and the form of loading. Verification has been carried out through experimental method.

  18. The insect-trapping rim of Nepenthes pitchers: surface structure and function.

    Bauer, Ulrike; Federle, Walter

    2009-11-01

    Carnivorous pitcher plants of the genus Nepenthes capture prey with a pitfall trap that relies on a micro-structured, slippery surface. The upper pitcher rim (peristome) is fully wettable and causes insects to slip by aquaplaning on a thin water film. The high wettability of the peristome is probably achieved by a combination of hydrophilic surface chemistry, surface roughness and the presence of hygroscopic nectar. Insect foot attachment could be prevented by the delayed drainage of the thin water film between the adhesive pad and the surface. Drainage should be faster for insects with a hairy adhesive system; however, they slip equally on the wet peristome. Therefore the stability of the water film against dewetting appears to be the key factor for aquaplaning. New experimental techniques may help to clarify the detailed function of the pitcher plant peristome and to explore its potential for biomimetic applications. PMID:20009546

  19. High-R Walls for New Construction Structural Performance: Integrated Rim Header Testing

    DeRenzis, A. [NAHB Research Center, Upper Marlboro, MD (United States); Kochkin, V. [NAHB Research Center, Upper Marlboro, MD (United States); Wiehagen, J. [NAHB Research Center, Upper Marlboro, MD (United States)

    2013-01-01

    Two prominent approaches within the Building America Program to construct higher R-value walls have included use of larger dimension framing and exterior rigid foam insulation. These approaches have been met with some success; however for many production builders, where the cost of changing framing systems is expensive, the changes have been slow to be realized. In addition, recent building code changes have raised some performance issues for exterior sheathing and raised heel trusses, for example, that indicates a need for continued performance testing for wall systems. The testing methods presented in this report evaluate structural rim header designs over openings up to 6 ft wide and applicable to one- and two-story homes.

  20. Em busca do tradutor: Proust e Mérimée por Mário Quintana.

    Claudia Borges de Faveri

    2005-01-01

    Full Text Available Este artigo pretende estudar as traduções feitas pelo poeta brasileiro Mário Quintana de Carmen, de Prosper Mérimée e de À sombra das raparigas em flor (À l’ombre des jeunes filles en fleur, de Marcel Proust. Com base na análise das etapas do processo tradutório empreendida por Antoine Berman e na abordagem do “tradutor de carne e osso” de Anthony Pym, busca-se a voz tradutor sem acessar os originais, partindo da premissa de que o texto traduzido é capaz de falar por si só. Enfim, tendo em vista a estreita ligação do trabalho de tradução de Quintana com a Editora Globo de Porto Alegre, certo traço da história da tradução no Brasil se fará perceber.

  1. Physical model development for prediction of rim-layer formation in UO2 fuel

    Results of point defects and gas atom behaviour modelling in UO2 fuel are presented for the temperature conditions for rim-layer formation. The spatial profiles for vacancy and interstitial atom concentrations in the vicinity of the grain boundaries and near edge dislocations are different. In the initial stage of irradiation, the peak of vacancy concentration is near the grain boundary. During long irradiation the vacancy peak vanishes and a peak of interstitial atoms arises. Vacancy concentration can have a maximum close to the dislocation core. Analysis of gas atom mobility at low temperature irradiation indicates a reducing dependence of Xe effective diffusion coefficient on vacancy concentration. The developed physical models enable the proposal of explanations for experimental facts: grain diameter effect on the threshold for the beginning of fuel restructuring and priority formation of large bubbles on dislocation intersections. (author)

  2. Late Cainozoic drainage evolution in the Zambezi basin: Geomorphological evidence from the Kalahari rim

    Thomas, David S. G.; Shaw, Paul A.

    The development of the Zambezi drainage system is discussed within the framework of the post-Gondwana tectonic evolution of southern Africa. An internal drainage system, including teh proto-Upper Zambezi, has been progressively captured during the late Cainozoic by a more agressive coastwise system. Supporting geomorphic evidence is presented from the eastern Kalahari rim. Drainage alignments and gradients, and terrace sequences are discussed. Lacustrine features found on the present watershed between the Middle Zambezi and internal systems are described and explained as remnants of the former proto-Upper Zambezi tributary system. Their interaction with linear dune activity is also examined. Despite the problems of dating the drainage changes described, it is concluded that their elucidation is important in understanding sedimentation and landform development in the eastern part of the Kalahari basin.

  3. Ciclamato de sódio e rim fetal Sodium cyclamate and fetal kidney

    José Germano Ferraz de Arruda; Alex Tadeu Martins; Reinaldo Azoubel

    2003-01-01

    O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O ciclamato e a ciclohexilamina, seu principal metabólito, atravessam a barreira placentária em humanos e desse modo podem ser expostos ao feto. O rim de ratos pode ser afetado por elevadas doses de ciclamato de sódio. Estudos sobre ef...

  4. MRI of degenerative bone marrow lesions in experimental osteoarthritis of canine knee joints

    Objective. The objective of this study was to determine the value of MRI in the detection of degenerative bone marrow abnormalities in an animal osteoarthritis model. Design. In 10 dogs with experimentally induced unilateral osteoarthritis of the knee, MRI was performed using two-dimensional spin-echo (2D-SE) and three-dimensional gradient-echo (3D-GE) imaging. Contrast enhanced T1-weighted 2D-SE sequences were also obtained after injection of gadolinium-DTPA. The results were compared with the gross and histopathologic findings and with radiography. Results. Histopathologic specimens revealed 21 osteosclerotic lesions and 5 intraosseous cysts. On 2D-SE images, 24 of 26 lesions were detected, while 21 of 26 lesions were identified on 2D-GE sequences. Radiography, including conventional tomography, demonstrated 9 of 26 lesions. Regardless of the sequence weighting, all osteosclerotic lesions appeared hypointense on MRI. Signal loss in bone sclerosis resulted primarily from the reduction of intact fat marrow, the increased bone density being of secondary importance. Quantitative signal analysis allowed approximate estimation of the grade of sclerosis. On postcontrast images, sclerotic bone remained hypointense, although significant but non-specific enhancement relative to the normal fat marrow was observed. The extent of contrast enhancement did not correlate with the grade of osteosclerosis. All five cysts were readily diagnosed by MRI. Cysts displayed either central or marginal contrast enhancement within their cavities. Conclusions. MRI provides a sensitive method for the diagnosis of osteoarthritic bone abnormalities, allowing their differentiation from most non-degenerative subarticular lesions. (orig.). With 1 tab

  5. H2O maser emission from bright rimmed clouds in the southern hemisphere

    Valdettaro, R.; Chapman, J. M.; Lovell, J. E. J.; Palla, F.

    2007-04-01

    Context: Water maser emission is a powerful tracer of the presence of embedded sources in dense clouds since it requires elevated temperatures (>100 K) and densities (>107 cm-3) that can be found in circumstellar disks and/or jets/outflows associated with Young Stellar Objects. Bright rimmed clouds compressed by ionization fronts from nearby massive stars are considered good examples of externally triggered star formation, possibly resulting in the formation of massive stars. Aims: We aim to determine the water maser emission frequency and characteristics of 45 bright rimmed clouds in the southern hemisphere identified by Sugitani & Ogura (1994, ApJS, 92, 163). Methods: We have used the Tidbinbilla 70-m radiotelescope to perform a high sensitivity survey at 22.2 GHz of the maser emission from the 616-523 rotational transition of H2O molecules. Results: We found 7 water maser sources out of 44 (16% detection rate), 5 being new detections. With the exception of the maser associated with BRC 68, all the other maser are characterized by low integrated fluxes and luminosities. Conclusions: Most maser sources fall below the correlation between the H2O and far-infrared luminosity found in other studies towards a variety of star forming regions. These results are similar to those found in the companion survey of BRCs in the northern hemisphere by Valdettaro et al. (2005, A&A, 443, 535). The low detection frequency and the properties of water maser emission from BRCs indicate that low-mass star formation is the most natural outcome of the external compression induced by the ionization front from nearby massive stars. Based on observations obtained with the 70-m Tidbinbilla radiotelescope.

  6. La Niña diversity and Northwest Indian Ocean Rim teleconnections

    Hoell, Andrew; Funk, Christopher C.; Barlow, Mathew

    2014-01-01

    The differences in tropical Pacific sea surface temperature (SST) expressions of El Niño-Southern Oscillation (ENSO) events of the same phase have been linked with different global atmospheric circulation patterns. This study examines the dynamical forcing of precipitation during October–December (OND) and March–May (MAM) over East Africa and during December–March (DJFM) over Central-Southwest Asia for 1950–2010 associated with four tropical Pacific SST patterns characteristic of La Niña events, the cold phase of ENSO. The self-organizing map method along with a statistical distinguishability test was used to isolate La Niña events, and seasonal precipitation forcing was investigated in terms of the tropical overturning circulation and thermodynamic and moisture budgets. Recent La Niña events with strong opposing SST anomalies between the central and western Pacific Ocean (phases 3 and 4), force the strongest global circulation modifications and drought over the Northwest Indian Ocean Rim. Over East Africa during MAM and OND, subsidence is forced by an enhanced tropical overturning circulation and precipitation reductions are exacerbated by increases in moisture flux divergence. Over Central-Southwest Asia during DJFM, the thermodynamic forcing of subsidence is primarily responsible for precipitation reductions, with moisture flux divergence acting as a secondary mechanism to reduce precipitation. Eastern Pacific La Niña events in the absence of west Pacific SST anomalies (phases 1 and 2), are associated with weaker global teleconnections, particularly over the Indian Ocean Rim. The weak regional teleconnections result in statistically insignificant precipitation modifications over East Africa and Central-Southwest Asia.

  7. X-RAY PROPER MOTIONS AND SHOCK SPEEDS ALONG THE NORTHWEST RIM OF SN 1006

    We report the results of an X-ray proper-motion measurement for the NW rim of SN 1006, carried out by comparing Chandra observations from 2001 to 2012. The NW limb has predominantly thermal X-ray emission, and it is the only location in SN 1006 with significant optical emission: a thin, Balmer-dominated filament. For most of the NW rim, the proper motion is ?0.''30 yr–1, essentially the same as has been measured from the H? filament. Isolated regions of the NW limb are dominated by nonthermal emission, and here the proper motion is much higher, 0.''49 yr–1, close to the value measured in X-rays along the much brighter NE limb, where the X-rays are overwhelmingly nonthermal. At the 2.2 kpc distance to SN 1006, the proper motions imply shock velocities of ?3000 km s–1 and ?5000 km s–1 in the thermal and nonthermal regions, respectively. A lower velocity behind the H? filament is consistent with the picture that SN 1006 is encountering denser gas in the NW, as is also suggested by its overall morphology. In the thermally dominated portion of the X-ray shell, we also see an offset in the radial profiles at different energies; the 0.5-0.6 keV peak dominated by O VII is closer to the shock front than that of the 0.8-3 keV emission—due to the longer times for heavier elements to reach ionization states where they produce strong X-ray emission.

  8. RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays

    Stanislaus, Romesh; Carey, Mark; Deus, Helena F; Coombes, Kevin; Hennessy, Bryan T; Mills, Gordon B; Almeida, Jonas S

    2008-01-01

    Background Reverse Phase Protein Arrays (RPPA) are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technologies, substantial amounts of analytical data are generated. Over 1000 samples may be printed on a single nitrocellulose slide. Up to 100 different proteins may be assessed using immunoperoxidase or immunoflorescence techniques in order to determine relative amounts of protein expression in the samples of interest. Results In this report an RPPA Information Management System (RIMS) is described and made available with open source software. In order to implement the proposed system, we propose a metadata format known as reverse phase protein array markup language (RPPAML). RPPAML would enable researchers to describe, document and disseminate RPPA data. The complexity of the data structure needed to describe the results and the graphic tools necessary to visualize them require a software deployment distributed between a client and a server application. This was achieved without sacrificing interoperability between individual deployments through the use of an open source semantic database, S3DB. This data service backbone is available to multiple client side applications that can also access other server side deployments. The RIMS platform was designed to interoperate with other data analysis and data visualization tools such as Cytoscape. Conclusion The proposed RPPAML data format hopes to standardize RPPA data. Standardization of data would result in diverse client applications being able to operate on the same set of data. Additionally, having data in a standard format would enable data dissemination and data analysis. PMID:19102773

  9. The Refined Shock Velocity of the X-Ray Filaments in the RCW 86 Northeast Rim

    Yamaguchi, Hiroya; Katsuda, Satoru; Castro, Daniel; Williams, Brian J.; Lopez, Laura A.; Slane, Patrick O.; Smith, Randall K.; Petre, Robert

    2016-03-01

    A precise measurement of shock velocities is crucial for constraining the mechanism and efficiency of cosmic-ray (CR) acceleration at supernova remnant (SNR) shock fronts. The northeastern rim of the SNR RCW 86 is thought to be a particularly efficient CR acceleration site, owing to the recent result in which an extremely high shock velocity of ˜6000 km s-1 was claimed. Here, we revisit the same SNR rim with the Chandra X-ray Observatory, 11 years after the first observation. This longer baseline than previously available allows us to determine a more accurate proper motion of the nonthermal X-ray filament, revealing a much lower velocity of 3000 ± 340 km s-1 (and even slower at a brighter region). Although the value has dropped to one-half of that from the previous X-ray measurement, it is still higher than the mean velocity of the Hα filaments in this region (˜1200 km s-1). This discrepancy implies that the filaments bright in nonthermal X-rays and Hα emission trace different velocity components, and thus a CR pressure constrained by combining the X-ray kinematics and the Hα spectroscopy can easily be overestimated. We also measure the proper motion of the thermal X-ray filament immediately to the south of the nonthermal one. The inferred velocity (720 ± 360 km s-1) is significantly lower than that of the nonthermal filament, suggesting the presence of denser ambient material, possibly a wall formed by a wind from the progenitor, which has drastically slowed down the shock.

  10. RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays

    Hennessy Bryan T

    2008-12-01

    Full Text Available Abstract Background Reverse Phase Protein Arrays (RPPA are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technologies, substantial amounts of analytical data are generated. Over 1000 samples may be printed on a single nitrocellulose slide. Up to 100 different proteins may be assessed using immunoperoxidase or immunoflorescence techniques in order to determine relative amounts of protein expression in the samples of interest. Results In this report an RPPA Information Management System (RIMS is described and made available with open source software. In order to implement the proposed system, we propose a metadata format known as reverse phase protein array markup language (RPPAML. RPPAML would enable researchers to describe, document and disseminate RPPA data. The complexity of the data structure needed to describe the results and the graphic tools necessary to visualize them require a software deployment distributed between a client and a server application. This was achieved without sacrificing interoperability between individual deployments through the use of an open source semantic database, S3DB. This data service backbone is available to multiple client side applications that can also access other server side deployments. The RIMS platform was designed to interoperate with other data analysis and data visualization tools such as Cytoscape. Conclusion The proposed RPPAML data format hopes to standardize RPPA data. Standardization of data would result in diverse client applications being able to operate on the same set of data. Additionally, having data in a standard format would enable data dissemination and data analysis.

  11. Bisphosphonate-Related Osteonecrosis of the Jaw Bone: Radiological Pattern and the Potential Role of CBCT in Early Diagnosis

    James Olutayo

    2010-04-01

    Full Text Available Objectives: To systematize the clinico-radiological symptoms and course of bisphosphonate-related osteonecrosis of jaw bone and to evaluate the diagnostic potential of various radiological techniques to detect mild osteonecrosis in each stage of the disease.Material and Methods: The sample consisted of 22 patients previously diagnosed with extraoral malignant disease. Diagnosis was based on a clinical examination in conjunction to digital panoramic radiography and cone beam computed tomography (CBCT. Two dentomaxillofacial radiologists reviewed all images.Results: Twenty patients showed mandibular involvement clinically, while two others had a maxillary involvement. Four stages of the disease were proposed based on the clinico-radiological findings. Subclinical cortical and lamina dura thickening was detected with only three-dimensional CBCT and periapical images, while ulceration and cortical bone thickening was detected only by three-dimensional CBCT. Mixed sclerotic, lytic bone destruction involving alveolar and basal bone with or without encroachment on the mandibular canal, pathological mandibular fractures were detected by two-dimensional panoramic and three-dimensional CBCT images. Other findings are non healing extraction sockets, periapical radiolucencies, osteolysis, sequestra, oroantral fistula, and periosteal new bone formation.Conclusions: The present study showed that bisphosphonate-related osteonecrosis of jaw bone occurs in four distinct clinico-radiological stages. For mild cases, panoramic image diagnosis was much less obvious, whereas cone beam computed tomography was able to fully characterise the bony lesions and describe their extent and involvement of neighbouring structures in all cases. Thus cone beam computed tomography might better contribute to the prevention of bisphosphonate-related osteonecrosis of jaw bone as well to the disease management.

  12. BONE IN OSTEOPETROSIS

    Ramkumar

    2014-04-01

    Full Text Available Osteopetrosis, a generalized developmental bone disease due to genetic disturbances, characterized by failure of bone re sorption and continuous bone formation making the bone hard, dense and brittle. Bones of intramembranous ossification and enchondrial ossification are affected genetically and symmetrically. During the process of disease the excess bone formation obliterates the cranial foramina and presses the optic, auditory and facial nerves resulting in defective vision, impaired hearing and facial paralysis. The bone formation in osteopetrosis affects bone marrow function leading to severe anemia and deficient of blood cells. The bone devoid of blood supply due to compression of blood vessels by excess formation of bone are prone to osteomyelitic changes with suppuration and pathological fracture if exposed to infection. Though the condition is chronic progressive, it produces changes leading to fatal condition, it should be studied thoroughly by everyone and hence this article presents a classical case of osteopetrosis with detailed description and discussion for the benefit of readers

  13. Nd and Sr isotope compositions in modern and fossil bones - Proxies for vertebrate provenance and taphonomy

    Tütken, Thomas; Vennemann, Torsten W.; Pfretzschner, Hans-U.

    2011-10-01

    Rare earth elements (REE), while not essential for the physiologic functions of animals, are ingested and incorporated in ppb concentrations in bones and teeth. Nd isotope compositions of modern bones of animals from isotopically distinct habitats demonstrate that the 143Nd/ 144Nd of the apatite can be used as a fingerprint for bedrock geology or ambient water mass. This potentially allows the provenance and migration of extant vertebrates to be traced, similar to the use of Sr isotopes. Although REE may be enriched by up to 5 orders of magnitude during diagenesis and recrystallization of bone apatite, in vivo143Nd/ 144Nd may be preserved in the inner cortex of fossil bones or enamel. However, tracking the provenance of ancient or extinct vertebrates is possible only for well-preserved archeological and paleontological skeletal remains with in vivo-like Nd contents at the ppb-level. Intra-bone and -tooth REE analysis can be used to screen for appropriate areas. Large intra-bone Nd concentration gradients of 10 1-10 3 are often measured. Nd concentrations in the inner bone cortex increase over timescales of millions of years, while bone rims may be enriched over millenial timescales. Nevertheless, ? Nd values are often similar within one ? Nd unit within a single bone. Larger intra-bone differences in specimens may either reflect a partial preservation of in vivo values or changing ? Nd values of the diagenetic fluid during fossilization. However, most fossil specimens and the outer rims of bones will record taphonomic 143Nd/ 144Nd incorporated post mortem during diagenesis. Unlike REE patterns, 143Nd/ 144Nd are not biased by fractionation processes during REE-uptake into the apatite crystal lattice, hence the ? Nd value is an important tracer for taphonomy and reworking. Bones and teeth from autochthonous fossil assemblages have small variations of ±1 ? Nd unit only. In contrast, fossil bones and teeth from over 20 different marine and terrestrial fossil sites have a total range of ? Nd values from -13.0 to 4.9 ( n = 80), often matching the composition of the embedding sediment. This implies that the surrounding sediment is the source of Nd in the fossil bones and that the specimens of this study seem not to have been reworked. Differences in ? Nd values between skeletal remains and embedding sediment may either indicate reworking of fossils and/or a REE-uptake from a diagenetic fluid with non-sediment derived ? Nd values. The latter often applies to fossil shark teeth, which may preserve paleo-seawater values. Complementary to ? Nd values, 87Sr/ 86Sr can help to further constrain the fossil provenance and reworking.

  14. Does running strengthen bone?

    Boudenot, Arnaud; Achiou, Zahra; Portier, Hugues

    2015-12-01

    Bone is a living tissue needing mechanical stress to maintain strength. Traditional endurance exercises offer only modest effects on bone. Walking and running produce low impact but lead to bone fatigue. This article is specifically addressed to therapists and explains the mechanisms involved for the effects of exercise on bone. Intermittent exercise limits bone fatigue, and downhill exercises increase ground impact forces and involve eccentric muscle contractions, which are particularly osteogenic. PMID:26562001

  15. Metastatic bone disease

    Errol U. Hutagalung

    2004-01-01

    Metastatic bone disease is the most common malignancy of bone, it is estimated that 70% of all malignant bone tumors are metastatic in origin. At autopsy it has been reported between 30 to 85% of patients who die from cancer show occult skeletal metastases. Bone is the third most common site of metastatic process after lung and liver. 80% of metastatic bone disease arise from Ca of breast, prostate, lung, kidney and thyroid. Typical location are thoracolumbal spine, pelvis, ribs, skull and pr...

  16. Application of bone scintigraphy

    Bone scanning has varied applications, particularly in the file of oncology. It is used in the diagnosis and follow-up of patients with cancers that metastatize to the bones (breast, prostate CA), also in primary bone cancers, infections of the bones and joints. In early stages of primary breast CA (stage I and II), the incidence of unsuspected bone metastasis is only 1-5%. On the other hand, bone scans serve as a baseline study if bone mets occur at some later stage. In patients with stage II and III breast CA, the conversion from normal to abnormal bone scans is 15% and 17%, respectively, clearly in favor of a baseline bone scan. For prostate CA, bone scanning should be used in conjunction with PSA level determination. In advanced disease, a bone scan will define the extent of the metastases, show problematic lesions in weight-bearing bones, and even allow us to evaluate response to therapy in follow-up bone scans. In patients with lung CA, a positive bone scan will make surgery of the primary lesion inappropriate. For other cancers, a bone scan maybe used if there are other signs, whether clinical or chemical, indicating bone involvement. In patients with GIT, liver, skin, brain or bladder CA, routine bone scanning may be considered superfluous. For patients with suspected infection, a 3-phase bone scan is more desirable. In patients with septic arthritis, the bones of each side of the joint take up the radiopharmaceutical while in patients with cellulitis without bony involvement, only the first two phases (dynamic and bloodpool images) will be abnormal. Bone scanning is also used in avascular lesions such as Legg-calve-Perthes disease where one will see reduced uptake of Tc99m MDP. The advent of SPECT imaging has greatly increased the sensitivity in diagnosing AVN. (author)

  17. Anorexia Nervosa and Bone

    Misra, Madhusmita; Klibanski, Anne

    2014-01-01

    Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone mass, impaired bone structure and reduced bone strength, all of which contribute to increased fracture risk., Adolescents with AN have decreased rates of bone accrual compared with normal-weight controls, raising addition concerns of suboptimal peak bone mass and future bone health in this age group. Changes in lean mass and compartmental fat depots, hormonal alterations secondary to nutritional factors contribute to impaired bone metabolism in AN. The best strategy to improve bone density is to regain weight and menstrual function. Oral estrogen-progesterone combinations are not effective in increasing bone density in adults or adolescents with AN, and transdermal testosterone replacement is not effective in increasing bone density in adult women with AN. However, physiologic estrogen replacement as transdermal estradiol with cyclic progesterone does increase bone accrual rates in adolescents with AN to approximate that in normal-weight controls, leading to a maintenance of bone density Z-scores. A recent study has shown that risedronate increases bone density at the spine and hip in adult women with AN. However, bisphosphonates should be used with great caution in women of reproductive age given their long half-life and potential for teratogenicity, and should be considered only in patients with low bone density and clinically significant fractures when non-pharmacological therapies for weight gain are ineffective. Further studies are necessary to determine the best therapeutic strategies for low bone density in AN. PMID:24898127

  18. Anorexia nervosa and bone.

    Misra, Madhusmita; Klibanski, Anne

    2014-06-01

    Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone mass, impaired bone structure, and reduced bone strength, all of which contribute to increased fracture risk. Adolescents with AN have decreased rates of bone accrual compared with normal-weight controls, raising additional concerns of suboptimal peak bone mass and future bone health in this age group. Changes in lean mass and compartmental fat depots, and hormonal alterations secondary to nutritional factors contribute to impaired bone metabolism in AN. The best strategy to improve bone density is to regain weight and menstrual function. Oral estrogen-progesterone combinations are not effective in increasing bone density in adults or adolescents with AN, and transdermal testosterone replacement is not effective in increasing bone density in adult women with AN. However, physiological estrogen replacement as transdermal estradiol with cyclic progesterone does increase bone accrual rates in adolescents with AN to approximate that in normal-weight controls, leading to a maintenance of bone density Z-scores. A recent study has shown that risedronate increases bone density at the spine and hip in adult women with AN. However, bisphosphonates should be used with great caution in women of reproductive age, given their long half-life and potential for teratogenicity, and should be considered only in patients with low bone density and clinically significant fractures when non-pharmacological therapies for weight gain are ineffective. Further studies are necessary to determine the best therapeutic strategies for low bone density in AN. PMID:24898127

  19. 76 FR 14697 - Aleris Blanking and Rim Products, Inc., a Division of Aleris International, Inc., Terre Haute, IN...

    2011-03-17

    ... the Federal Register on March 2, 2010 (75 FR 9436-9437). The workers produce aluminum blanks and hoops... International, Inc., Terre Haute, IN; Notice of Revised Determination on Reconsideration On February 18, 2010... Blanking and Rim Products, Inc., a division of Aleris International, Inc., Terre Haute, Indiana, who...

  20. The Effects of Self-Shadowing by a Puffed up Inner Rim in Scattered Light Images of Protoplanetary Disks

    Dong, Ruobing

    2015-01-01

    We explore whether protoplanetary disks with self-shadowing from puffed up inner rims exhibit observable features in scattered light images. We use both self-consistent hydrostatic equilibrium calculations and parameterized models to produce the vertically puffed up inner rims. We find that, in general, the transition between the shadowed and flared regions occurs in a smooth manner over a broad radius range, and no sudden jump exists at the outer edge of the shadow in either the disk temperature or density structures. As a result, a puffed up rim cannot create sharp ring/arc/spiral-arm-like features in the outer disk as have been detected in recent direct NIR imaging of disks. On the other hand, if the puffed up rim has a sharp edge in the vertical direction, the shadowing effect can produce a distinct 3-stage broken power law in the radial intensity profile of the scattered light, with 2 steep surface brightness radial profiles in the inner and outer disk joined by a shallow transition region around the sha...

  1. Observation of a high burnup rim-type structure in an advanced plutonium-uranium carbide fuel

    The observation is reported of a 'rim-type' structure with small subgrains in an advanced plutonium-uranium carbide (U0.8Pu0.2)C fuel pin, which had been irradiated in the Dounreay Fast Reactor to a burnup of 8.3% FIMA. (orig.)

  2. 75 FR 52969 - Rim of the Valley Corridor Special Resource Study, Los Angeles and Ventura Counties, CA; Notice...

    2010-08-30

    ... environmental impact analysis ] process to identify and assess potential impacts of alternative resource... linkages between open space areas; completion of the Rim of the Valley Trail system; preserving... local and regional press media, and will be advertised in a newsletter which will be distributed...

  3. Isotopic distribution from core to rim of a PWR spent nuclear fuel by shielded laser ablation ICP MS

    Spent nuclear fuel discharged from a pressurized light water reactor contains fission products, U, Pu, and other actinides. Due to a neutron capture by 238U in the rim region and a temperature gradient between the center and the rim of a fuel pellet, a considerable increase in the concentration of fission products, U, Pu, and other actinides are expected at a pellet periphery. Characterization of the local chemical properties with a varying radial gradient is our main concern. For an analysis, a spent nuclear fuel originating from the Yeonggwang 4 PWR reactor with an average burn up of 55,600 MWd/MtU was chosen as a test specimen. The isotopic ratio was measured from core to rim of the spent fuel by a radiation shielded LA ICP MS system. Sampling was performed along the diameter of a sample specimen by reducing the intervals from 500μm to 100μm. It was observed that the isotopic ratios in the center of a sample specimen remain almost constant and increased near the pellet periphery due to the rim effect. In addition, the isotopic distribution measured by the radiation shielded LA ICP MS was compared with that of the calculated value by the Origin2 code

  4. Heterogenous Oxygen Isotopic Composition of a Complex Wark-Lovering Rim and the Margin of a Refractory Inclusion from Leoville

    Simon, J. I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.

    2014-01-01

    Wark-Lovering (WL) rims [1] surrounding many refractory inclusions represent marker events in the early evolution of the Solar System in which many inclusions were exposed to changes in pressure [2], temperature [3], and isotopic reservoirs [4-7]. The effects of these events can be complex, not only producing mineralogical variability of WL rims [2], but also leading to mineralogical [8-10] and isotopic [7, 11, 12] changes within inclusion interiors. Extreme oxygen isotopic heterogeneity measured in CAIs has been explained by mixing between distinct oxygen gas reservoirs in the nebula [13]. Some WL rims contain relatively simple mineral layering and/or are isotopically homogeneous [14, 15]. As part of a larger effort to document and understand the modifications observed in some CAIs, an inclusion (L6) with a complex WL rim from Leoville, a member of the reduced CV3 subgroup was studied. Initial study of the textures and mineral chemistry was presented by [16]. Here we present NanoSIMS oxygen isotopic measurements to complement these petrologic observations.

  5. Thermal and fluid processes of a thin melt zone during femtosecond laser ablation of glass: the formation of rims by single laser pulses

    We study the formation mechanism of rims created around femtosecond laser ablated craters on glass. Experimental studies of the surface morphology reveal that a thin rim is formed around the smooth craters and is raised above the undamaged surface by about 50-100 nm. To investigate the mechanism of rim formation following a single ultrafast laser pulse, we perform a one-dimensional theoretical analysis of the thermal and fluid processes involved in the ablation process. The results indicate the existence of a very thin melted zone below the surface and suggest that the rim is formed by the high pressure plasma producing a pressure-driven fluid motion of the molten material outwards from the centre of the crater. The numerical solutions of pressure-driven fluid motion of the thin melt demonstrate that the melt can flow to the crater edge and form a rim within the first nanoseconds of the ablation process. The possibility that a tall rim can be formed during the initial stages of the plasma is suggestive that the rim may tilt outwards towards the low pressure region creating a resolidified melt splash as observed in the experiments. The possibility of controlling or suppressing the rim formation is discussed also

  6. Reactive endosteal bone formation

    Aoki, Jun; Yamamoto, Itsuo; Hino, Megumu; Kitamura, Nobuyasu; Sone, Teruki; Itoh, Harumi; Torizuka, Kanji

    1987-10-01

    The microstructure of reactive endosteal new bone was examined using undecalcified ground sections in five pathologic conditions (bone metastasis from prostate cancer in seven cases, intervertebral osteochondrosis in five, Paget disease in four, chronic suppurative osteomyelitis in two, and fracture healing in one). To determine a basic form of rapid intramembranous bone formation, fetal rat calvaria and primitive bones made in clonal osteogenic cell culture were also observed. In slow bone-forming conditions, lamellar new bone was deposited on pre-existing trabecular surface and caused trabecular thickening on radiographs. In contrast, in rapid bone-forming conditions, woven bone was deposited as spicules extending from trabecular surface so as to form new networks on intertrabecular space. This causes obscurity of trabecular margins radiographically. Reactive endosteal bone formation may be nonspecific and have a significance for assessing the virulence of underlying pathologic conditions like periosteal reactions.

  7. Studies on the abnormal accumulations in vertebrae found on the bone scintigram in cancer patients

    From Jan. 1975 to Dec. 1977, 700 patients with various types of cancer were examined by bone scanning with sup(99m)Tc-phosphate compounds for metastatic bone lesions at the National Cancer Center Hospital. Among these selected 156 patients, significant accumulations were found in 120, and equivocal in 21. The remaining 15 showed both significant and equivocal accumulations. In 116 out of 135 (120 + 15) patients, the significant accumulations were due to metastases; and in 19 out of 36 (21 + 15) patients, the equivocal accumulations were due to metastases. Our careful investigation disclosed that some of the benign conditions could present somewhat different scintigraphic patterns from the metastases. These are as follows; (1) a cushion-like accumulation in the intervertebral space in the cases with disc degeneration, which is occasionally noted also in the cases with collapse of the vertebral body, (2) an irregular marginal accumulation of the vertebral body with an occasional cushion-like accumulation in the intervertebral space in the cases spondylosis deformans, (3) a vague and equivocal accumulation covering an entire vertebral body with an occasional extension to the next vertebral body in the cases with spondylosis deformans, (4) symmetrical accumulations in the intervertebral joints due to sclerotic changes. The 4th pattern mentioned above may be noted in the cases with metastases also. (author)

  8. Preservation of deep Himalayan PT conditions that formed during multiple events in garnet cores: Mylonitization produces erroneous results for rims

    Sapkota, J.; Sanislav, I. V.

    2013-03-01

    The Kathmandu Thrust Sheet, which overlies the Lesser Himalayas along the southern part of the Main Central Thrust (MCT) and forms the leading edge of the Higher Himalayan crystalline rocks, is folded at a regional scale by the Gorkha-Kathmandu fold couplet in Central Nepal. Garnet porphyroblasts lying close to the MCT within this thrust sheet preserve structural and metamorphic history that predates mylonitization during thrust emplacement. The succession of five FIA sets preserved within these porphyroblasts formed due to changes in the direction of India's motion relative to Asia after they collided. The intersection of Fe, Ca and Mn isopleths for garnet cores reveals that FIA sets 1, 2, 3, 4 and 5 nucleated respectively at 6.2 kbar and 515 °C, 6-7 kbar and 545-550 °C, 6.6 kbar and 530 °C, 5.6-6.2 kbar and 525-550 °C and 6.8-6.9 kbar and 520-560 °C. The average PT mode of THERMOCALC, which relies on equilibrium being achieved between the garnet rims and the matrix, gives pressures around 11 kbar that do not accord with the lengthy succession of lower core pressures. The many foliations in the matrix, which formed during top to the south thrusting plus subsequent deformations that eventually led to these rocks reaching the surface, truncate all foliations preserved within the porphyroblasts that are defined by inclusion trails. This has resulted in the garnet rims not being in equilibrium with the matrix and the anomalously high pressures. The garnet rims may have been affected by slow dissolution and solution transfer over the period of time that the matrix was deforming plastically at high strain rates as the rocks were uplifted. The assumption of equilibrium between garnet rims and surrounding silicates used by various rim geothermobarometric methods does not hold for these rocks.

  9. Roentgenological semiotics of bone and bone joints pathology

    Physiologic and pathologic processes in bones followed by alternations of bone structure and reflected on roentgenograms are considered and described. Most frequent reasons for roentgenodiagnosis errors in diseases of bone and bone joint apparatus are presented

  10. The rim zone of cement based materials - barrier or fast lane for chemical degradation?

    This contribution focuses exemplarily on the chemical and mineralogical changes in the rim zone of cement paste samples exposed to different chloride solutions (NaCl, KCl, MgCl2 and CaCl2), to hard tap water and to demineralized water. The determination of the Ca(OH)2 and Mg(OH)2 content of the solid phases was performed by means of thermogravimetry with pulverized samples (TGA/SDTA 851, Mettler-Toledo). A potential relation between temperature and the time dependant development of the material due to reactive transport processes will also be addressed. The experiments with tap water showed that the contact between the cement paste samples and hard tap water did not lead to significant changes in the composition of the solid samples or of the reaction solution. This can be attributed to a rapid formation of a protective calcium carbonate layer on the surface of the cement paste. The slight decrease of the Ca2+ content in the solution indicates that the growth of this layer occurs within the first few hours. In contrast to the tap water exposure, the results of the experiments with the MgCl2 solutions show features of an intense attack despite the presence of crystalline covering layers. The quick formation of a thick and dense Mg(OH)2 layer does not provide any protection against reactive transport processes. In this experiment, the degradation rate of Ca(OH)2 as well as the Ca2+ release was higher than in all other experiments. In addition the rapid formation of a Mg(OH)2 layer starting already during the first hour of the experiment did not prevent the chloride ingress compared to the other experiments with chloride solutions. The pH value of the reaction solution remains stable and relatively low which indicates a crystallisation process. In the other experiments, performed with demineralized water, alkali chloride solutions, and the CaCl2 solution, no significant formation of potentially protective covering layers and no development of transport inhibiting properties in the rim zone were observed

  11. Enfermedad de Paget en Chile: una serie de 15 pacientes Paget disease of bone: Report of 15 cases

    Gilberto González V

    2003-05-01

    Full Text Available Background: Paget disease of bone (PD is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and methods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained data from 15 patients with PD (ten males, eight Chilean, six European and one Asian, eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit. Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Méd Chile 2003; 131: 491-7.

  12. Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions

    Balliu, E. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: eballiu@gmail.com; Vilanova, J.C. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: Kvilanova@comg.es; Pelaez, I. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: isapelaezrx@yahoo.es; Puig, J. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: jpuigalcantara@yahoo.es; Remollo, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sremollo@gmail.com; Barcelo, C. [Department of Computer Science and Applied Mathematics, University of Girona (Spain)], E-mail: carles.barcelo@udg.es; Barcelo, J. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: rmgirona@comg.es; Pedraza, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sapedraza@gmail.com

    2009-03-15

    Aim: The aim of this study is to evaluate the value of the apparent diffusion coefficient (ADC) obtained in diffusion-weighted (DW) MR sequences for the differentiation between malignant and benign bone marrow lesions. Method: Forty-five patients with altered signal intensity vertebral bodies on conventional MR sequences were included. The cause of altered signal intensity was benign osteoporotic collapse in 16, acute neoplastic infiltration in 15, and infectious processes in 14; based on plain-film, CT, bone scintigraphy, conventional MR studies, biopsy or follow-up. All patients underwent isotropic DW MR images (multi-shot EPI, b values of 0 and 500 s/mm{sup 2}). Signal intensity at DW MR images was evaluated and ADC values were calculated and compared between malignancy, benign edema and infectious spondylitis. Results: Acute malignant fractures were hyperintense compared to normal vertebral bodies on the diffusion-weighted sequence, except in one patient with sclerotic metastases. Mean ADC value from benign edema (1.9 {+-} 0.39 x 10{sup -3} mm{sup 2}/s) was significantly (p < 0.0001) higher than untreated metastasic lesions (0.9 {+-} 1.3 x 10{sup -3} mm{sup 2}/s). Mean ADC value of infectious spondilytis (0.96 {+-} 0.49 x 10{sup -3} mm{sup 2}/s) was not statistically (p > 0.05) different from untreated metastasic lesions. ADC value was low (0.75 x 10{sup -3} mm{sup 2}/s) in one case of subacute benign fracture. Conclusions: ADC values are a useful complementary tool to characterize bone marrow lesions, in order to distinguish acute benign fractures from malignant or infectious bone lesions. However, ADC values are not valuable in order to differentiate malignancy from infection.

  13. Bone Marrow Aspiration and Biopsy

    ... be limited. Home Visit Global Sites Search Help? Bone Marrow Aspiration and Biopsy Share this page: Was this page helpful? Also known as: Bone Marrow; Bone Marrow Examination Formal name: Bone Marrow ...

  14. Bone marrow (stem cell) donation

    ... lymphoma , and myeloma can be treated with a bone marrow transplant . This is now often called a stem cell ... are two types of bone marrow donation: Autologous bone marrow transplant is when people donate their own bone marrow. " ...

  15. Bone Graft Alternatives

    ... spinal deformity, or who have some types of disc herniations. In certain types of spinal fusion, bone grafts or bone graft alternatives are used to replace the cushioning disc material that lies between the vertebrae. When the ...

  16. Bone mineral density test

    BMD test; Bone density test; Bone densitometry; DEXA scan; DXA; Dual-energy x-ray absorptiometry; p-DEXA; Osteoporosis-BMD ... need to undress. This scan is the best test to predict your risk of fractures. Peripheral DEXA ( ...

  17. Petrographic and SIMS pyrite sulfur isotope analyses of Ediacaran chert nodules: Implications for microbial processes in pyrite rim formation, silicification, and exceptional fossil preservation

    Xiao, Shuhai; Schiffbauer, James D.; McFadden, Kathleen A.; Hunter, Jerry

    2010-09-01

    The lower Ediacaran Doushantuo Formation in the Yangtze Gorges area contains exceptionally preserved microfossils, including the earliest known animal resting eggs and embryos. These fossils are preserved in cm-sized chert nodules, which typically have a microbial mat fragment in the center, a silica cortex, a pyrite rim, and an outer rim of blocky calcite. Petrographic analysis indicates that the formation of the blocky calcite rim postdates that of the pyrite rim and silica cortex. The pyrite rim grew centripetally during early diagenesis, representing a reaction front that was determined by the dynamics between ambient Fe 2+ and H 2S, the latter of which was derived from bacterial sulfate reduction (BSR) of mat fragment in nodule center. The silica cortex was formed pervasively through replacement of carbonate sediments prior to compaction. Secondary ion mass spectroscopy (SIMS) sulfur isotopes of individual pyrite crystals (δ 34S py - SIMS) in pyrite rims and matrices show highly positive values (15.2-39.8‰). The pyrite rims do not show an isotopic gradient between small crystals formed in outer rim during early diagenesis and large crystals formed in inner rim during subsequent overgrowth. Although rim pyrite in the same chert nodule has consistent δ 34S py - SIMS values, there are significant spatial and stratigraphic variations in δ 34S py - SIMS values of both matrix and rim pyrite. Overall, isotopic fractionation between pyrite and carbonate associated sulfate (CAS) is small (< 22‰). The isotopic and petrographic data can be interpreted as evidence for rapid BSR of highly metabolizable organic matter in a diagenetic environment with limited sulfate availability, local anoxia, high Fe 2+ concentration, and low sedimentation rate. The embryonic nodules nucleated on microbial mat fragments and stayed in the BSR zone during early diagenesis, when rapid BSR in the nodule center generated outward-diffusing H 2S that was confined by readily available Fe 2+ to precipitate the pyrite rim. The precipitation of the silica cortex was facilitated by localized pH change related to BSR and pyrite precipitation, with silica sourced from silica-rich Precambrian seawater and from microbially mediated clay diagenesis. Like the pyrite rim, the silica cortex was also formed rapidly during early diagenesis, leading to the exceptional preservation of microfossils within these nodules.

  18. Chemical Analysis of Reaction Rims on Olivine Crystals in Natural Samples of Black Dacite Using Energy-Dispersive X-Ray Spectroscopy, Lassen Peak, CA.

    Graham, N. A.

    2014-12-01

    Lassen Volcanic Center is the southernmost volcanic region in the Cascade volcanic arc formed by the Cascadia Subduction Zone. Lassen Peak last erupted in 1915 in an arc related event producing a black dacite material containing xenocrystic olivine grains with apparent orthopyroxene reaction rims. The reaction rims on these olivine grains are believed to have formed by reactions that ensued from a mixing/mingling event that occurred prior to eruption between the admixed mafic andesitic magma and a silicic dacite host material. Natural samples of the 1915 black dacite from Lassen Peak, CA were prepared into 15 polished thin sections and carbon coated for analysis using a FEI Quanta 250 Scanning Electron Microscope (SEM) to identify and measure mineral textures and disequilibrium reaction rims. Observed mineralogical textures related to magma mixing include biotite and amphibole grains with apparent dehydration/breakdown rims, pyroxene-rimmed quartz grains, high concentration of microlites in glass matrix, and pyroxene/amphibole reaction rims on olivine grains. Olivine dissolution is evidenced as increased iron concentration toward convolute edges of olivine grains as observed by Backscatter Electron (BSE) imagery and elemental mapping using NSS spectral imaging software. In an attempt to quantify the area of reaction rim growth on olivine grains within these samples, high-resolution BSE images of 30 different olivine grains were collected along with Energy-Dispersive X-Ray Spectroscopy (EDS) of different phases. Olivine cores and rims were extracted from BSE images using Photoshop and saved as separate image files. ImageJ software was used to calculate the area (μm2) of the core and rim of these grains. Average pyroxene reaction rim width for 30 grains was determined to be 11.68+/-1.65 μm. Rim widths of all 30 grains were averaged together to produce an overall average rim width for the Lassen Peak black dacite. By quantifying the reaction rims on olivine grains in the natural samples of Lassen Peak dacite as well as the bulk chemistry of the rock, this provides insight into the storage conditions of the magma chamber and the timing necessary for reactions to form these specific volcanic textures which in turn can be used as a basis for better understanding future experimental reconstruction of this magmatic system.

  19. Magnetic resonance imaging of bone marrow changes in Gaucher disease during enzyme replacement therapy: first German long-term results

    Poll, L.W.; Koch, J.A.; Scherer, A.; Boerner, D.; Moedder, U. [Duesseldorf Univ. (Germany). Inst. fuer Diagnostische Radiologie; Dahl, S. vom; Niederau, C.; Haeussinger, D. [Duesseldorf Univ. (Germany). Medizinische Fakultaet; Willers, R. [Duesseldorf Univ. (Germany). Rechenzentrum

    2001-09-01

    Objective:. Since 1991, enzyme replacement therapy (ERT) has been available for patients with Gaucher disease in Germany. The aim of this study was to analyse the MR pattern of bone marrow involvement and response to ERT in Gaucher disease type I. Patients and design:. Thirty patients with Gaucher disease type I had MRI examinations prior to initiation of ERT with alglucerase/imiglucerase and during follow-up. Median MR follow-up and duration of ERT were 36 months. Coronal T1- and T2-weighted spin-echo images of the lower extremities were obtained to evaluate changes in the appearance of yellow marrow. MR images were categorized as having either a homogeneous (type A) or non-homogeneous patchy (type B) appearance of bone involvement and response to ERT was assessed by two radiologists. Results:. Overall, 19 of 30 patients (63%) showed an increased signal intensity on T1- and T2-weighted images after 36 months of ERT, consistent with partial reconversion of fatty marrow during treatment. Focal bone lesions surrounded by a low signal intensity (SI) rim did not respond to ERT, suggesting bone infarcts. Of the 11 patients with bone infarcts (low SI rim lesion), 82% had the non-homogeneous type B pattern (P=0.0021). In 86% of patients with splenectomy, bone infarcts were seen (P<0.05). Conclusions:. MRI using T1- and T2-weighted spin-echo sequences is a valuable, non-invasive method for monitoring bone marrow response in patients receiving ERT. A non- homogeneous patchy signal intensity of bone marrow involvement correlates with the presence of bone infarcts (P=0.0021). (orig.)

  20. Magnetic resonance imaging of bone marrow changes in Gaucher disease during enzyme replacement therapy: first German long-term results

    Objective:. Since 1991, enzyme replacement therapy (ERT) has been available for patients with Gaucher disease in Germany. The aim of this study was to analyse the MR pattern of bone marrow involvement and response to ERT in Gaucher disease type I. Patients and design:. Thirty patients with Gaucher disease type I had MRI examinations prior to initiation of ERT with alglucerase/imiglucerase and during follow-up. Median MR follow-up and duration of ERT were 36 months. Coronal T1- and T2-weighted spin-echo images of the lower extremities were obtained to evaluate changes in the appearance of yellow marrow. MR images were categorized as having either a homogeneous (type A) or non-homogeneous patchy (type B) appearance of bone involvement and response to ERT was assessed by two radiologists. Results:. Overall, 19 of 30 patients (63%) showed an increased signal intensity on T1- and T2-weighted images after 36 months of ERT, consistent with partial reconversion of fatty marrow during treatment. Focal bone lesions surrounded by a low signal intensity (SI) rim did not respond to ERT, suggesting bone infarcts. Of the 11 patients with bone infarcts (low SI rim lesion), 82% had the non-homogeneous type B pattern (P=0.0021). In 86% of patients with splenectomy, bone infarcts were seen (P<0.05). Conclusions:. MRI using T1- and T2-weighted spin-echo sequences is a valuable, non-invasive method for monitoring bone marrow response in patients receiving ERT. A non- homogeneous patchy signal intensity of bone marrow involvement correlates with the presence of bone infarcts (P=0.0021). (orig.)

  1. BONE MECHANOTRANSDUCTION: A REVIEW

    Reis, Joana; Capela e Silva, Fernando; Queiroga, Cristina; Lucena, Sónia; Potes, José

    2011-01-01

    This review focus on the bone physiology and mechanotransduction elements and mechanisms. Bone biology and architecture is deeply related to the mechanical environment. Orthopaedic implants cause profound changes in the biomechanics and electrophysiology of the skeleton. In the context of biomedical engineering, a deep reflexion on bone physiology and electromechanics is needed. Strategic development of new biomaterials and devices that respect and promote continuity with bone str...

  2. Gracile bone dysplasias

    Gracile bone dysplasias constitute a group of disorders characterised by extremely slender bones with or without fractures. We report four newborns, two of whom showed multiple fractures. Two babies had osteocraniostenosis and one had features of oligohydramnios sequence. The diagnosis in the fourth newborn, which showed thin long bones and clavicles and extremely thin, poorly ossified ribs, is uncertain. Exact diagnosis of a gracile bone dysplasia is important for genetic counselling and medico-legal reasons. (orig.)

  3. Bone densitometry and osteoporosis

    The purpose of this book is to provide a perspective on the current status of bone densitometry and its relevance to osteoporosis diagnosis and management. Therefore, this book will give the reader an introduction to the nature of osteoporosis, its pathophysiology and epidemiology, and the clinical consequences of performing bone densitometry. Aside from standard bone densitometry, newer technologies such as quantitative ultrasound techniques, magnetic resonance imaging and bone structure analysis are discussed in the context of diagnosing osteoporosis. (orig.)

  4. Eating disorders and bone.

    Tomlinson, Dale; Morgan, Sarah L

    2013-01-01

    Low bone mineral density (BMD) is a frequent and often-overlooked consequence of eating disorders, in particular anorexia nervosa and eating disorders associated with the female athlete triad. The causes of low BMD are multifactorial and include low peak bone mass accrual, accelerated bone resorption, and changes in bone microarchitecture. Early diagnosis and interventions focused on nutritional rehabilitation and weight gain reduce the risk of further BMD deficits and fractures. PMID:24094471

  5. High-mass star formation within the bright-rimmed cloud SFO 79

    Urquhart, J S; White, L

    2004-01-01

    We report Radio Recombination Line (RRL) and continuum observations toward the IRAS point source 16362--4845, embedded within the Bright-Rimmed Cloud (BRC) SFO 79, a small molecular cloud lying at the edge of the HII region RCW 108. High resolution observations of the H92alpha hydrogen recombination line and of the continuum emission (3.6 and 6 cm) confirm the presence of a resolved Ultra Compact (UC) HII region embedded within the molecular cloud. The integrated radio fluxes suggest the source of the ionisation to be an O9 Zero Age Main Sequence (ZAMS) star. Millimetre observations of 12CO, 13CO and C18O (J=1--0) molecular lines reveal the presence of a molecular condensation offset \\~30 arcsec to the north of the IRAS position on the boundary of the UC HII region. Analysis of 2MASS data has led to the identification of a small IR cluster of Young Stellar Objects (YSOs) that are positionally coincident with the UC HII region, lying to the south east of the peak of the radio emission. Moreover, the UC HII reg...

  6. Spitzer-Selected Young Stellar Objects in Two Bright Rimmed Clouds

    Johnson, Chelen H.; Rebull, L. M.; Gibbs, J. C.; Linahan, M.; Sartore, D. C.; Legassie, M.; Laher, R.; Killingstad, N. G.; McCanna, T. S.; O'Bryan, A. M.; Carlson, S. D.; Clark, M. L.; Koop, S. M.; Ravelomanantsoa, T. A.; Nuthmann, T. R.; Canakapalli, T. S.; Aryal, S.; Nishida, M. M.; Ramswaram, A.; Sprow, H. N.; Pullinger, A.; Ezyk, N. J.; Fagan, J. R.; Tilley, C. M.; Badura, K. S.

    2012-01-01

    Found near the edges of HII regions, bright-rimmed clouds (BRCs) are thought to be home to triggered star formation. Using Spitzer Space Telescope archival data, we investigated two BRCs, BRC 27 and BRC 34, to search for previously known and new candidate additional young stellar objects (YSOs). BRC 27 is located in the molecular cloud Canis Majoris R1, a known site of star formation. BRC 34 has a variety of features worthy of deeper examination: dark nebulae, molecular clouds, emission stars, and IR sources. Our team used archival Spitzer InfraRed Array Camera (IRAC) and Multiband Imaging Photometer for Spitzer (MIPS), combined with 2-Micron All-Sky Survey (2MASS) data. We investigated the infrared properties of previously known YSOs and used infrared colors to identify additional new candidate YSOs in these regions. This research was made possible through the NASA/IPAC Teacher Archive Research Project (NITARP) and was funded by NASA Astrophysics Data Program and Archive Outreach funds.

  7. The Chandra View of the Triggered Star Formation in Bright Rimmed Clouds

    Feigelson, Eric; Getman, K.

    2009-01-01

    The formation of mamy stars in the Galaxy appears to be triggered by some external compression processes such as OB ionization, winds or supernovae shocks. However, quantitative understanding of triggering processes is still primitive. The radiation driven implosion (RDI) is currently considered as the most observationally testable model using bright rimmed clouds (BRCs) on the edges of large HII regions. We have made several short observations with the Chandra X-ray Observatory to elucidate the mechanism, efficiency and stellar populations produced by small-scale triggered star formation around HII regions. X-ray selection is effective in tracing triggered low mass stars from protostellar through disk-free stages, both embedded in the cloud and in the unobscured cloud vicinity. The results of these studies are presented and generally support the RDI model. Triggering by HII region shocks is not restricted to a single episode, but can continue for millions of years. We discuss plans for the collection of BRC young star samples at different morphological stages of the triggering and cloud ablation process to test RDI predictions and to quantify the role of RDI in Galactic star formation.

  8. Building for the Pacific Rim Countries. Energy-efficient building strategies for hot, humid climates

    Sheinkopf, K. [ed.

    1991-09-01

    This book has been published by the Solar Energy Industries Association (SEIA), the US trade association of the solar thermal, photovoltaic, and passive solar manufacturers, distributors, and component suppliers. Its purpose is to help architects, builders, and developers construct energy-efficient homes in hot humid climates like the Pacific Rim Countries, and to allow occupants of these homes to enjoy enhanced comfort without reliance on mechanical air-conditioning systems. Two important factors are addressed in this book. First, the past few years have seen a tremendous increase in practical applications of new research. The current popularity of ceiling paddle fans, attic radiant barriers and natural daylighting attest to the importance of keeping up with the latest concepts in energy-reduction and comfort-awareness. Professionals who have been in the field for the past few years may be unaware of the latest research findings--some of which dramatically alter prior thinking on such subjects as natural ventilation or mechanical air conditioning. The second factor is the importance of site-specific characteristics, which greatly affect building strategies and designs. A thorough understanding of the climate is a prerequisite to good building design. Such factors as temperature, humidity, wind speed and direction, and solar radiation must be understood and properly integrated into the design for the home to be truly energy-efficient.

  9. Physiological characterization of the compound eye in monarch butterflies with focus on the dorsal rim area.

    Stalleicken, Julia; Labhart, Thomas; Mouritsen, Henrik

    2006-03-01

    The spectral, angular and polarization sensitivities of photoreceptors in the compound eye of the monarch butterfly (Danaus plexippus) are examined using electrophysiological methods. Intracellular recordings reveal a spectrally homogenous population of UV receptors with optical axes directed upwards and >or=10 degrees to the contralateral side. Based on optical considerations and on the opsin expression pattern (Sauman et al. 2005), we conclude that these UV receptors belong to the anatomically specialized dorsal rim area (DRA) of the eye. Photoreceptors in the main retina with optical axes <10 degrees contralateral or ipsilateral have maximal sensitivities in the UV (lambda(max)

  10. Radiation thermo-chemical models of protoplanetary disks I. Hydrostatic disk structure and inner rim

    Woitke, Peter; Thi, Wing-Fai

    2009-01-01

    This paper introduces a new disk code, called ProDiMo, to calculate the thermo-chemical structure of protoplanetary disks and to interpret gas emission lines from UV to sub-mm. We combine frequency-dependent 2D dust continuum radiative transfer, kinetic gas-phase and UV photo-chemistry, ice formation, and detailed non-LTE heating & cooling balance with the consistent calculation of the hydrostatic disk structure. We include FeII and CO ro-vibrational line heating/cooling relevant for the high-density gas close to the star, and apply a modified escape probability treatment. The models are characterized by a high degree of consistency between the various physical, chemical and radiative processes, where the mutual feedbacks are solved iteratively. In application to a T Tauri disk extending from 0.5AU to 500AU, the models are featured by a puffed-up inner rim and show that the dense, shielded and cold midplane (z/r<0.1, Tg~Td) is surrounded by a layer of hot (5000K) and thin (10^7 to 10^8 cm^-3) atomic ga...

  11. Ciclamato de sódio e rim fetal / Sodium cyclamate and fetal kidney

    José Germano Ferraz de, Arruda; Alex Tadeu, Martins; Reinaldo, Azoubel.

    2003-06-01

    Full Text Available O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O ciclamato e a ciclohexilamina, seu p [...] rincipal metabólito, atravessam a barreira placentária em humanos e desse modo podem ser expostos ao feto. O rim de ratos pode ser afetado por elevadas doses de ciclamato de sódio. Estudos sobre efeitos do ciclamato de sódio na espécie humana são necessários, pois, além de poder substituir a sacarose - prejudicial em casos de diabetes ou quando o controle e a redução do peso corporal são essenciais para a saúde dos pacientes - não propicia desenvolvimento de cárie dentária. Abstract in english Cyclamate is used as an artificial non-caloric sweetener in a variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It is present in the formula of products such as sodium and calcium cyclamates and cyclamic acid. Cyclamate and cyclohexylamine, [...] its principal metabolite, can cross the human placenta exposing the fetus. It has been demonstrated in rats that the kidney may be adversely affected by high doses of cyclamate. Studies on the effects of sodium cyclamate in the human species are necessary, because in addition to replacing saccharose - harmful in individuals with diabetes or patients in whom weight reduction and control are essential for health - it does not cause dental caries.

  12. The Difference in Translaminar Pressure Gradient and Neuroretinal Rim Area in Glaucoma and Healthy Subjects

    Siaudvytyte, Lina; Ragauskas, Arminas; Meiliuniene, Indre; Harris, Alon

    2014-01-01

    Purpose. To assess differences in translaminar pressure gradient (TPG) and neuroretinal rim area (NRA) in patients with normal tension glaucoma (NTG), high tension glaucoma (HTG), and healthy controls. Methods. 27 patients with NTG, HTG, and healthy controls were included in the prospective pilot study (each group consisted of 9 patients). Intraocular pressure (IOP), intracranial pressure (ICP), and confocal laser scanning tomography were assessed. TPG was calculated as the difference of IOP minus ICP. ICP was measured using noninvasive two-depth transcranial Doppler device. The level of significance P 0.05). The difference between TPG for healthy (5.4(7.7) mmHg) and glaucomatous eyes (NTG 6.3(3.1) mmHg, HTG 15.7(7.7) mmHg) was statistically significant (P < 0.001). Higher TPG was correlated with decreased NRA (r = −0.83; P = 0.01) in the NTG group. Conclusion. Translaminar pressure gradient was higher in glaucoma patients. Reduction of NRA was related to higher TPG in NTG patients. Further prospective studies are warranted to investigate the involvement of TPG in glaucoma management. PMID:24876948

  13. Structural studies of eight bright rimmed clouds in the southern hemisphere

    Sharma, Saurabh; Borissova, J; Ojha, D K; Ivanov, V D; Ogura, K; Kobayashi, N; Kurtev, R; Gopinathan, M; Yadav, Ram Kesh

    2016-01-01

    We carried out deep and wide-field near- and mid-infrared observations for a sample of 8 bright-rimmed clouds (BRCs). Supplemented with the $Spitzer$ archival data, we have identified and classified 44 to 433 young stellar objects (YSOs) associated with these BRCs. The Class I sources are generally located towards the places with higher extinction and are relatively closer to each other than the Class II sources, confirming that the young protostars are usually found in regions having denser molecular material. On the other hand the comparatively older population, Class II objects, are more randomly found throughout the regions, which can be due to their dynamical evolution. Using the minimal sampling tree analyses, we have extracted 13 stellar cores of 8 or more members, which contains 60\\% of the total YSOs. The typical core is $\\sim$0.6 pc in radii and somewhat elongated (aspect ratio of 1.45), of relatively low stellar density (surface density 60 pc$^{-2}$), consisting of a small (35) number of YSOs of re...

  14. Model for evolution of grain size in the rim region of high burnup UO2 fuel

    Xiao, Hongxing; Long, Chongsheng; Chen, Hongsheng

    2016-04-01

    The restructuring process of the high burnup structure (HBS) formation in UO2 fuel results in sub-micron size grains that accelerate the fission gas swelling, which will raise some concern over the safety of extended the nuclear fuel operation life in the reactor. A mechanistic and engineering model for evolution of grain size in the rim region of high burnup UO2 fuel based on the experimental observations of the HBS in the literature is presented. The model takes into account dislocations evolution under irradiation and the grain subdivision occur successively at increasing local burnup. It is assumed that the original driving force for subdivision of grain in the HBS of UO2 fuel is the production and accumulation of dislocation loops during irradiation. The dislocation loops can also be annealed through thermal diffusion when the temperature is high enough. The capability of this model is validated by the comparison with the experimental data of temperature threshold of subdivision, dislocation density and sub-grain size as a function of local burnup. It is shown that the calculated results of the dislocation density and subdivided grain size as a function of local burnup are in good agreement with the experimental results.

  15. AN INVESTIGATION ON THE MORPHOLOGICAL EVOLUTION OF BRIGHT-RIMMED CLOUDS

    A new radiative driven implosion (RDI) model based on smoothed particle hydrodynamics technique is developed and applied to investigate the morphological evolutions of molecular clouds under the effect of ionizing radiation. This model self-consistently includes the self-gravity of the cloud in the hydrodynamical evolution, the UV radiation component in the radiation transferring equations, the relevant heating and cooling mechanisms in the energy evolution, and a comprehensive chemical network. The simulation results reveal that under the effect of ionizing radiation, a molecular cloud may evolve through different evolutionary sequences. Depending on its initial gravitational state, the evolution of a molecular cloud does not necessarily follow a complete morphological evolution sequence from type A→B→C, as described by previous RDI models. When confronted with observations, the simulation results provide satisfactory physical explanations for a series of puzzles derived from bright-rimmed clouds observations. The consistency of the modeling results with observations shows that the self-gravity of a molecular cloud should not be neglected in any investigation on the dynamical evolution of molecular clouds when they are exposed to ionizing radiation.

  16. Mixed multiplicities for arbitrary ideals and generalized Buchsbaum-Rim multiplicities

    We introduce first the notion of mixed multiplicities for arbitrary ideals in a local d-dimensional noetherian ring (A, m) which, in some sense, generalizes the concept of mixed multiplicities for m-primary ideals. We also generalize Teissier's Product Formula for a set of arbitrary ideals. We also extend the notion of the Buchsbaum-Rim multiplicity (in short, we write BR-multiplicity) of a submodule of a free module to the case where the submodule no longer has finite colength. For a submodule M of Ap we introduce a sequence eBRk(M), k = 0,...,d + p - 1 which in the ideal case coincides with the multiplicity sequence c0(I, A),...,cd(I, A) defined for an arbitrary ideal I of A by Achilles and Manaresi in [AM]. In case that M has finite colength in Ap and it is totally decomposable we prove that our BR-multiplicity sequence essentially falls into the standard BR-multiplicity of M. (author)

  17. H$_2$O maser emission from bright rimmed clouds in the northern hemisphere

    Valdettaro, R; Brand, J; Cesaroni, R

    2005-01-01

    We report the results of a multi-epoch survey of water maser observations at 22.2 GHz with the Medicina radiotelescope from 44 bright rimmed clouds (BRCs) of the northern hemisphere identified by Sugitani et al. (1989) as potential sites of star formation. The data span 16 years of observations and allow to draw conclusions about the maser detection rate in this class of objects. In spite of the relatively high far-infrared luminosities of the embedded sources ($L_{\\rm FIR}\\ga 10^2$ L$_\\odot$), H$_2$O maser emission was detected towards three globules only. Since the occurrence of water masers is higher towards bright IRAS sources, the lack of frequent H$_2$O maser emission is somewhat surprising if the suggestion of induced intermediate- and high-mass star formation within these globules is correct. The maser properties of two BRCs are characteristic of exciting sources of low-mass, while the last one (BRC~38) is consistent with an intermediate-mass object. We argue that most BRCs host young stellar objects ...

  18. Personalized Message Routing Policy in Pervasive eHealth Applications Based on HL7 RIM.

    Guizani, Nachoua; Fayn, Jocelyne

    2015-01-01

    The design of relevant message routing strategies that provide reliable communications between different healthcare actors is deemed among one of the most challenging requirements to enhance QoS in eHealth applications. In this paper, we propose a data and context-driven model that aims to support the design of personalized, intelligent and adaptive eHealth message routing policies. Our model is suitably complying with HL7 v3, an international standard for healthcare information exchange. In the proposed model, we highlight the sensitivity of routing services applications to message, source and target ecosystems contextual information. We point out the relevant HL7 Reference Information Model (RIM) elements that are related to our research objective which is to deliver the message to the right healthcare provider with respect to the required delays for message reception, reading and reply, according to the content of the message and to the clinical and social situation of the patient. Moreover, we include AmI to make the routing policy intelligently adaptive to context changes at run-time. PMID:25980880

  19. Early radiologic detection of local recurrence after curettage and acrylic cementation of giant cell tumours

    Five patients with giant cell tumour of bone, treated with curettage and acrylic cementation, were suspected of having recurrence of tumour 6 months - 6 years after surgery. At repeat surgery, recurrence was histologically verified in three patients, and excluded in two. A review of the radiologic examinations of these patients showed that the only reliable sign of early recurrence showed that the only reliable sign of early recurrence was lysis or non-development of the sclerotic rim adjacent to the radiolucent zone between the cement and the cancellous bone, detectable on conventional radiographs and tomographs. Angiography and scintimetry were not reliable during the first year after the primary surgery. (orig.)

  20. Medicines and Bone Loss

    ... be enough to lower the risk. Healthy Bone Osteoporosis Which medicines can cause bone loss? A number of medicines can cause ... Adjusting your current medicines. If your medicines may cause bone loss, make sure ... osteoporosis medicines. Some medicines can prevent or treat osteoporosis. ...

  1. Development of a thermal conductivity correlation for the pellet rim region and its application to the analysis of behaviour of high burnup fuel

    A thermal conductivity correlation has been proposed which can be applied to high burnup fuel by considering the degradation of thermal conductivity with burnup at pellet rim due to very high porosity. In addition, a correlation has been developed that can estimate the porosity of rim region as a function of rim burnup under the assumptions that all the produced fission gases are retained in the rim porosity and threshold pellet average burnup required for the formation of rim region is 40 MWD/kgU. Rim width is correlated to rim burnup using measured data. For the RISO experimental data obtained at pellet average burnup of 43.5 MWD/kgU for three linear heat generation rates of 30, 35 and 40 kW/m, radial temperature distributions were calculated using the present correlation and compared with the measured ones. This comparison shows that the present correlation gives the best agreement with the measured data when it is combined with HALDEN's correlation for thermal conductivity which considers its degradation with burnup, another comparison with HALDEN's measured fuel centerline temperature as a function of burnup at 25 kW/m up to about 44 MWD/kgU also suggests that the present correlation yields the best agreement when it is combined with HALDEN's thermal conductivity. (author)

  2. Rim enhancement in colorectal metastases at CT during infusion hepatic arteriography. Does it represent liver parenchyma or live tumor cell zone?

    Purpose: To evaluate the morphologic substrate of the rim enhancement of colorectal mestastases seen at CT during infusion hepatic arteriography (CTIHA). Material and Methods: Eleven sector defects in the enhancing rim of 9 metastases at CTIHA were analyzed. The corresponding pathologic specimens were investigated for sector defects of liver parenchyma. We investigated whether there was a correlation between the central angle of the sector defects of rim enhancement at CTIHA and that of sector defects in the zone of liver parenchyma in histologic slices. The inner and outer diameters of the enhancing rim were also compared with the diameter of the metastases as seen at CT during arterial portography (CTAP). Results: There was a significant correlation between the central angle of sector defects of rim enhancement at CTIHA and the angle of sector defects in the zone of liver parenchyma in histologic slices (p=0.008, Spearman's test). The diameter of the metastases measured at CTAP was larger than the inner diameter and smaller than the outer diameter of the enhancing rim in CTIHA, i.e. the margins of the nodules as seen in CTAP are located in liver parenchyma and not in tumor tissue. Conclusion: The morphologic substrate of the rim enhancement of colorectal metastases seen at CTIHA is liver parenchyma. (orig.)

  3. Tin in Human Bones

    Jambor, Jaroslav; Smreka, Vâclav

    1993-01-01

    TIN IN HUMAN BONES. The tin content in the bones of 149 skeletons from the 1st - 5th centuries A.D., and of 11 individuals of the recent population was determined. The bone samples were carbonized and analyzed through emission spectroscopy with a.c. excitation. The tin content in bones of recent populations not exposed to extra tin supply is about one order of magnitude higher than is the case with the bones od some populations that lived at the beginning of our era. The distribut...

  4. Method for fusing bone

    Mourant, Judith R. (Los Alamos, NM); Anderson, Gerhard D. (Velarde, NM); Bigio, Irving J. (Los Alamos, NM); Johnson, Tamara M. (Los Alamos, NM)

    1996-01-01

    Method for fusing bone. The present invention is a method for joining hard tissue which includes chemically removing the mineral matrix from a thin layer of the surfaces to be joined, placing the two bones together, and heating the joint using electromagnetic radiation. The goal of the method is not to produce a full-strength weld of, for example, a cortical bone of the tibia, but rather to produce a weld of sufficient strength to hold the bone halves in registration while either external fixative devices are applied to stabilize the bone segments, or normal healing processes restore full strength to the tibia.

  5. Enzymatic maceration of bone

    Uhre, Marie-Louise; Eriksen, Anne Marie; Simonsen, Kim Pilkjær; Redsted Rasmussen, Arne; Hjort, Benjamin Benn; Niels Lynnerup, Niels

    2015-01-01

    afterwards macerated by one of the two methods. DNA extraction was performed to see the effect of the macerations on DNA preservation. Furthermore, the bone pieces were examined in a stereomicroscope to assess for any bone damage. The results demonstrated that both methods removed all flesh/soft tissue from...... the bones. The DNA analysis showed that DNA was preserved on all the pieces of bones which were examined. Finally, the investigation suggests that enzyme maceration could be gentler on the bones, as the edges appeared less frayed. The enzyme maceration was also a quicker method; it took three hours...

  6. Enzymatic maceration of bone

    Uhre, Marie-Louise; Eriksen, Anne Marie; Simonsen, Kim Pilkjær; Rasmussen, Arne Redsted; Hjort, Benjamin Benn; Lynnerup, Niels

    2014-01-01

    afterwards macerated by one of the two methods. DNA extraction was performed to see the effect of the macerations on DNA preservation. Furthermore, the bone pieces were examined in a stereomicroscope to assess for any bone damage. The results demonstrated that both methods removed all flesh/soft tissue from...... the bones. The DNA analysis showed that DNA was preserved on all the pieces of bones which were examined. Finally, the investigation suggests that enzyme maceration could be gentler on the bones, as the edges appeared less frayed. The enzyme maceration was also a quicker method; it took three hours...

  7. An Investigation of the Type M Morphological Structure of IC59: A New Model for Bright Rim Clouds?

    Miao, Jingqi; Sugitani, Koji; White, Glenn J.; Nelson, Richard P.

    2010-07-01

    We report the results from a smoothed particle hydrodynamics simulation designed to model recent observational data on the nebula and Bright Rim Cloud IC59. We further examine, in the context of radiative-driven implosion (RDI) models, the possible formation mechanisms of the morphological structure of IC59. The results of the simulation reveal the existence of a new, fourth morphological state for Bright Rim Clouds (BRCs)—which we propose to call a Type M BRC morphology. We discuss the necessary conditions for the appearance of Type M BRCs, based on analytical and numerical simulations. The simulated physical properties from our model are consistent with the available observations of IC59. We further show that the prospect of RDI triggered star formation in all Type M BRCs is not supported by the simulations.

  8. Deep Drawing for high LDR by a new Hydro-rim Forming Process with Differential Temperature- Analysis and Experiments

    The purpose of this study is to analyze and test a possible increase of the Limit Drawing Ratio (LDR) in Deep Drawing by Hydro-rim process (a certain subset of the classical Hydroforming) which includes the newly differential temperature effect. The idea is to facilitate the plastic flow by local heating along the flange and to cool the area where strength is needed. The suggested analysis is based on the dual bounds approach (upper and lower bounds simultaneously) using the highly versatile Johnson-Cook constitutive material model. The advantage of combined high hydraulic pressure (about 1000 bar) with relatively high blank temperature (with magnitude of about one third the melting temperature of the considered material) in the same operation is discussed. Emphasis is given to the rule of blank temperature difference (between the flange and the wall of the product) conjugate with optimal hydro rim pressure in increasing the limit drawing ratio of the products (Aluminum, Copper and various Steels)

  9. Trace element analysis of precious metals in minerals by time-of-flight resonance ionization mass spectrometry (TOF-RIMS)

    Dimov, Stamen S.; Chryssoulis, Stephen L.; Lipson, Robert H.

    2001-08-01

    The TOF-RIMS Mass Spectrometer, developed at AMTEL, has been successfully applied for quantitative trace element analysis of Au, Pd and Rh in sulphides, iron oxides and silicates. A series of experiments were conducted in order to test the applicability and determine the detection sensitivity of several one and two step resonant ionization schemes related to Au, Pd and Rh. The experimental data are compared with the corresponding theoretical estimates. Attained minimum detection limits are in the 8-17 ppb range with precision of ±15%. A comparative study of minerals by Dynamic SIMS and TOF-RIMS in the overlapping range of detection sensitivities for Au, Pd and Rh shows good correlation of the quantified data.

  10. A world perspective of the back-end fuel cycle and its significance for the Pacific rim countries

    There are currently two options available for the management of irradiated fuel. The first is reprocessing and recycle, and the second is the direct disposal of fuel following some form of storage and treatment. Interim storage is not an option but a deferral of the decision of which option to take. This paper identifies the major issues which are important in deciding on which option to follow and examines the possible implications for Pacific Rim Countries. Reprocessing and direct disposal are likely to remain complementary technologies for the foreseeable future, but it is the strategic significance of recycle that beckons with reduced dependence on energy imports within the Pacific Rim. This is challenged only by the perceptions of risks of and related attitudes to, nuclear weapons proliferation. This latter is a matter that can only be resolved at political level with international consensus

  11. [Bone turnover marker].

    Miura, Masakazu; Satoh, Yuki

    2015-10-01

    Recently the clinical application of bone turnover markers (BTMs) have been achieved significant progress and the measurements of these indices give us better understanding of pathogenesis of osteoporosis. BTMs are known the bone formation marker, the bone resorption marker and the bone matrix-related marker, respectively. In the Guidelines for the Use of Bone Metabolic Markers in the Diagnosis and Treatment of Osteoporosis (2012 Edition) from publishing Japan Osteoporosis Society Committee, the newly and commonly BTMs were considered to give the normal reference value in Japanese people, the influence of renal function on BTMs. The flow chart of the measurement of bone resorption markers and bone formation markers when selecting drug treatment for osteoporosis, the evaluation of therapeutic effects of bone antiresorption drugs and/or bone formation promoting drug using bone resorption markers and/or bone formation marker were corrected newly in the guideline 2012 edition. Moreover, BTMs were suggested to contribute to adhere with osteoporosis treatment. BTMs are adapted to selection of the drug for osteoporosis and to evaluate the drug efficacy. Therefore, it is very important to guide the proper application and assessment of BTMs in clinical practice. PMID:26529926

  12. Matsu Cultural Heritage and Its Conservation in Bohai Rim - Case Study on the Hall of Fujian in Yantai

    Yao, S.

    2015-08-01

    Since the Yuan Dynasty, the belief of Matsu had started to spread from the birthplace to the northern coastal areas in China. Matsu worship developed to the pinnacle with the official promotion on account of the government's dependence on grain transported by sea since the mid-Qing Dynasty. A large amount of Matsu temples emerged in coastal cities of Bohai Rim where it still keeps a large number of them until now. It has much relationship between the spread of Matsu culture and the flow of Fujian population. It was one of the main building way that the Matsu temples attached to the local hall of Fujian in Bohai Rim. The Hall of Fujian in Yantai, Which was built with materials taken from Fujian, in the feature of traditional architectural style from QuanZhou, is very different from the local building style of Yantai. This case indicates that maritime culture of the south area had spread and developed in the north areas under the promotion of the population flow and the economic transaction. The essay introduces briefly about the development of Matsu culture in Bohai Rim and takes the case study of the Hall of Fujian in Yantai analyzing its causes and features, and the value as Matsu heritage. Then the paper will discuss the conservation of Matsu culture mere include the tangible and the intangible culture heritage around the origin area, the heritages of the spread area also have the same importance significance. With the evolution of the society, it calls urgent attention and protection of Matsu culture in Bohai Rim.

  13. The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences

    Clemson, Christine Moulton; Hall, Lisa L; Byron, Meg; McNeil, John; Lawrence, Jeanne Bentley

    2006-01-01

    We investigated whether genes escape X chromosome inactivation by positioning outside of the territory defined by XIST RNA. Results reveal an unanticipated higher order organization of genes and noncoding sequences. All 15 X-linked genes, regardless of activity, position on the border of the XIST RNA territory, which resides outside of the DAPI-dense Barr body. Although more strictly delineated on the inactive X chromosome (Xi), all genes localized predominantly to the outer rim of the Xi and...

  14. RC-IAL: linhagem celular contínua de rim de coelho - características e substrato para replicação de vírus

    Cruz Aurea Silveira; Figueiredo Cristina Adelaide; Barbosa Maria Luisa; Martinez Clelia Helena de O.; Salles-Gomes Luís Florêncio de

    1992-01-01

    Uma linhagem celular de rim de coelho (denominada RC-IAL), que foi isolada em 1976, e que atualmente está na 150ª passagem, teve suas características analisadas. As células apresentaram morfologia semelhante aos fibroblastos desde o início de seu cultivo. A proporção de crescimento celular não se alterou desde seu isolamento, com uma eficiência de clonagem ao redor de 9%. A linhagem mostrou crescimento dependente de ancoragem, e a análise cromossômica apresentou o número modal da espécie com ...

  15. Monostotic Paget Disease of Bone or Bone Metastasis?

    Özlem Erdem Süer; Jale Meray; Nesrin Demirsoy; Zelal Keleş

    2008-01-01

    Paget’s disease of bone is a metabolic bone disorder with male predominance and characterized by increased bone turnover. Recent literature indicates a reduction in incidence and severity. We report a 55 years old female patient who was admitted with knee pain, and whose pelvis x-ray demonstrated pathological features. She was investigated with preliminary diagnoses of Paget’s disease of bone, osteosclerotic bone metastasis and primary bone tumor. Histopathological examination of bone biopsy ...

  16. Star formation in bright-rimmed clouds and cluster associated with W5 E H{\\sc ii} region

    Chauhan, Neelam; Ogura, K; Jose, J; Ojha, D K; Samal, M R; Mito, H

    2011-01-01

    The aim of this paper is to present the results of photometric investigations of the central cluster of the W5 E region as well as a follow-up study of the triggered star formation in and around bright-rimmed clouds (BRCs). We have carried out wide field $UBVI_c$ and deep $VI_c$ photometry of the W5 E H{\\sc ii} region. A distance of $\\sim$2.1 kpc and a mean age of $\\sim$1.3 Myr have been obtained for the central cluster. The young stellar objects (YSOs) associated with the region are identified on the basis of near-infrared and mid-infrared observations. We confirmed our earlier results that the average age of the YSOs lying on/inside the rim are younger than those lying outside the rim. The global distribution of the YSOs shows an aligned distribution from the ionising source to the BRCs. These facts indicate that a series of radiation driven implosion processes proceeded from near the central ionising source towards the periphery of the W5 E H{\\sc ii} region. We found that, in general, the age distributions...

  17. RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast.

    Kessi-Pérez, Eduardo I; Araos, Sebastián; García, Verónica; Salinas, Francisco; Abarca, Valentina; Larrondo, Luis F; Martínez, Claudio; Cubillos, Francisco A

    2016-05-01

    Different natural yeast populations have faced dissimilar selective pressures due to the heterogeneous fermentation substrates available around the world; this increases the genetic and phenotypic diversity inSaccharomyces cerevisiae In this context, we expect prominent differences between isolates when exposed to a particular condition, such as wine or sake musts. To better comprehend the mechanisms underlying niche adaptation between twoS. cerevisiaeisolates obtained from wine and sake fermentation processes, we evaluated fermentative and fungicide resistance phenotypes and identify the molecular origin of such adaptive variation. Multiple regions were associated with fermentation rate under different nitrogen conditions and fungicide resistance, with a single QTL co-localizing in all traits. Analysis around this region identifiedRIM15as the causative locus driving fungicide sensitivity, together with efficient nitrogen utilization and glycerol production in the wine strain. A nullRIM15variant confers a greater fermentation rate through the utilization of available glucose instead of its storage. However, this variant has a detrimental effect on fungicide resistance since complex sugars are not synthesized and transported into the membrane. Together, our results reveal the antagonist pleiotropic nature of aRIM15null variant, positively affecting a series of fermentation related phenotypes, but apparently detrimental in the wild. PMID:26945894

  18. A tale of two cores: Triggered massive star formation in the bright-rimmed cloud SFO 75

    Urquhart, J S; Morgan, L K; Pestalozzi, M R; White, G J; Muna, D N; White, Glenn J.

    2007-01-01

    Abridged: We present a detailed multi-wavelength study of the bright-rimmed cloud SFO 75, including 1.3cm and 1.2mm continuum, and 13CO and ammonia spectral line observations. The 13CO and 1.2 mm emission reveals the presence of a dense core located behind the bright rim of the cloud which is approximately coincident with that of the IRAS point source. From an analysis of the IRAS and 1.2mm fluxes we derive a dust temperature of ~30 K, a luminosity of 1.6x10^4 L\\odot and estimate the core mass to be ~570 M\\odot. The higher resolution ammonia observations resolve the 1.2mm core into two distinct cores, one directly behind the cloud's rim (Core A) and the second located slightly farther back (Core B). Comparing the morphology of Core A with that of the photon-dominated region and ionised boundary layer leaves little doubt that it is being strongly affected by the ionisation front. 2MASS and GLIMPSE archive data which reveal a small cluster of three deeply embedded high- and intermediate-mass young stellar objec...

  19. Effects of biodegradation on oil and gas field PVT properties and the origin of oil rimmed gas accumulations

    Larter, S. [Newcastle Univ. (United Kingdom). NRG Petroleum Group; Calgary Univ., AB (Canada); Primio, R. di [Norsk Hydro, Bergen (Norway); Geoforschungzentrum Potsdam (Germany)

    2005-02-01

    Dry gas overlying biodegraded oil rims is a common occurrence in the North Sea oil rimmed gas accumulations (ORGAs) and elsewhere in the world. Wet gas biodegradation occurs in Troll, Frigg, Balder and other ORGAs, with propane preferentially degraded over ethane, resulting in gases becoming dryer and oils heavier. We apply several models of biodegradation and compositional change to examine the effect of biodegradation on the physical properties and phase behaviour of degraded oils and compare the predicted results with data from real degraded oils. Several models, including gas biodegradation, gas cap compression and later interaction of undersaturated oil with dry gas caps can account for the ca. 10 m oil rim presence. Wet gas and oil degradation alone and divergent oil and gas physical properties during biodegradation can also account for the oil legs and dry gas caps. All the models rely on biodegradation of both oil and gas, which not only affects the chemical composition but also dramatically affects reservoir engineering properties such as saturation pressure, GOR and Bo. ORGAs seem to represent altered oil or gas accumulations where the heavy oil and dry gas are in equilibrium and are related. Classical admixed biogenic gas or high maturity origin for the dry gas are not needed to account for these accumulations though methane addition to the accumulations during oil biodegradation may sometimes be a dominant process. (Author)

  20. The spatial-temporal evolution of aerosol optical depth and the analysis of influence factors in Bohai Rim

    Aerosol Optical Depth (AOD) is an important parameter of aerosol optical properties and it is an important physical parameter quantity to understanding the atmospheric environment. Bohai Rim is one of the three major urban agglomeration regions with rapidly developing economy in China. The study of AOD over this region is important to understand the environment and climate in Bohai Rim. Firstly, aerosol product data from 2000 to 2010, published by NASA, were used to analyze the temporal-spatial evolution of AOD in Bohai Rim with precision evaluation. The results showed that the spatial distribution of AOD had an obvious regional characteristic. The spatial distribution characterized that a much high value existed at urban areas and plain areas. On the contrary, the low value data existed in some mountainous regions which had higher percentages of forest coverage. The AOD values fluctuated somewhat each year in the region, from the minimum annual mean in 2003 to the maximum in 2009. Generally, the highest AOD value was in summer, followed by spring, autumn and winter. In terms of monthly variation, the value of AOD reached its peak in June and the lowest value was in December. This study analyzed the relation between AOD and some influence factors such as land use types, elevation, and distribution of urban agglomeration and so on. These results provide an important basic dataset for climate and environmental research

  1. Ciclamato de sódio e rim fetal Sodium cyclamate and fetal kidney

    José Germano Ferraz de Arruda

    2003-06-01

    Full Text Available O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O ciclamato e a ciclohexilamina, seu principal metabólito, atravessam a barreira placentária em humanos e desse modo podem ser expostos ao feto. O rim de ratos pode ser afetado por elevadas doses de ciclamato de sódio. Estudos sobre efeitos do ciclamato de sódio na espécie humana são necessários, pois, além de poder substituir a sacarose - prejudicial em casos de diabetes ou quando o controle e a redução do peso corporal são essenciais para a saúde dos pacientes - não propicia desenvolvimento de cárie dentária.Cyclamate is used as an artificial non-caloric sweetener in a variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It is present in the formula of products such as sodium and calcium cyclamates and cyclamic acid. Cyclamate and cyclohexylamine, its principal metabolite, can cross the human placenta exposing the fetus. It has been demonstrated in rats that the kidney may be adversely affected by high doses of cyclamate. Studies on the effects of sodium cyclamate in the human species are necessary, because in addition to replacing saccharose - harmful in individuals with diabetes or patients in whom weight reduction and control are essential for health - it does not cause dental caries.

  2. Inertial effects at moderate Reynolds number in thin-film rimming flows driven by surface shear

    Kay, E. D.; Hibberd, S.; Power, H.

    2013-10-01

    In this paper, we study two-dimensional thin-film flow inside a stationary circular cylinder driven by an imposed surface shear stress. Modelling is motivated by a need to understand the cooling and film dynamics provided by oil films in an aero-engine bearing chamber characterised by conditions of very high surface shear and additional film mass flux from oil droplets entering the film through the surface. In typical high-speed operation, film inertial effects can provide a significant leading-order mechanism neglected in existing lubrication theory models. Inertia at leading-order is included within a depth-averaged formulation where wall friction is evaluated similar to hydraulic models. This allows key nonlinear inertial effects to be included while retaining the ability to analyse the problem in a mathematically tractable formulation and compare with other approaches. In constructing this model, a set of simplified mass and momentum equations are integrated through the depth of the film yielding a spatially one-dimensional depth-averaged formulation of the problem. An a priori assumed form of velocity profile is needed to complete the system. In a local Stokes flow analysis, a quadratic profile is the exact solution for the velocity field though it must be modified when inertial effects become important. Extension of the velocity profile to a cubic profile is selected enabling specification of a wall friction model to include the roughness of the cylinder wall. A modelling advantage of including the inertia term, relevant to the applications considered, is that a smooth progression in solution can be obtained between cases of low Reynolds number corresponding to lubrication theory, and high Reynolds number corresponding to uniform rimming-flow. Importantly, we also investigate the effect of inertia on some typical solutions from other studies and present a greater insight to existing and new film solutions which arise from including inertia effects.

  3. Monostotic Paget Disease of Bone or Bone Metastasis?

    Özlem Erdem Süer

    2008-06-01

    Full Text Available Paget’s disease of bone is a metabolic bone disorder with male predominance and characterized by increased bone turnover. Recent literature indicates a reduction in incidence and severity. We report a 55 years old female patient who was admitted with knee pain, and whose pelvis x-ray demonstrated pathological features. She was investigated with preliminary diagnoses of Paget’s disease of bone, osteosclerotic bone metastasis and primary bone tumor. Histopathological examination of bone biopsy confirmed Paget’s disease of bone and Paget’s disease of bone is reviewed. Turk J Phys Med Rehab 2008;54:73-6

  4. More Evidence of the Importance of Amorphous Silicates in CM Carbonaceous Chondrites: New Observations from a Fine-Grained Rim in the CM2 Chondrite, TIL 91722

    Brearley, A. J.; Le Guillou, C.

    2015-07-01

    A fine-grained rim in TIL 91722 contains abundant amorphous silicate material containing nanophase sulfides. Phyllosilicates are rare. The amorphous material has a high ferric iron content indicative of oxidation coupled with hydration.

  5. Human prostatic acid phosphatase directly stimulates collagen synthesis and alkaline phosphatase content of isolated bone cells

    Human prostatic acid phosphatase (hPAP) directly enhances the differentiated characteristics of isolated bone cells in vitro. This enzyme, when added to cell cultures for 24 h in vitro stimulates collagen synthesis and the production of alkaline phosphatase. The effects are dose dependent, with statistically significant effects occurring from 0.1-100 nM hPAP. Concentrations higher than 100 nM do not evoke greater effects. The maximal effect of hPAP occurs between 12 and 24 h of exposure. The cells stimulated to the greatest degree are osteoprogenitor cells and osteoblasts. Fibroblasts isolated from the same tissue show a lesser sensitivity to hPAP. hPAP has no detectable effect on cell proliferation, as measured by radiolabeled thymidine incorporation or total DNA synthesis. None of the observations reported in this work can be attributed to contaminating proteins in the hPAP preparation. hPAP was radiolabeled with 125I and was used for affinity binding and cross-linking studies. Scatchard analysis of specific binding indicated the presence of 1.0 X 10(5) high affinity binding sites/cell, with a Kd of 6.5 nM. Cross-linking studies demonstrated the presence of one 320-kDa binding complex. The pH profile and kinetic determinations of Km and maximum velocity for hPAP were similar to those previously reported, except for the finding of positive cooperativity of the substrate with the enzyme under the conditions of our assay. We believe that the direct stimulation of bone-forming cells by hPAP may contribute to the sclerotic nature of skeletal bone around sites of neoplastic prostatic metastases and that the effect of the enzyme is probably mediated by a plasma membrane receptor

  6. Biomaterials and bone mechanotransduction

    Sikavitsas, V. I.; Temenoff, J. S.; Mikos, A. G.; McIntire, L. V. (Principal Investigator)

    2001-01-01

    Bone is an extremely complex tissue that provides many essential functions in the body. Bone tissue engineering holds great promise in providing strategies that will result in complete regeneration of bone and restoration of its function. Currently, such strategies include the transplantation of highly porous scaffolds seeded with cells. Prior to transplantation the seeded cells are cultured in vitro in order for the cells to proliferate, differentiate and generate extracellular matrix. Factors that can affect cellular function include the cell-biomaterial interaction, as well as the biochemical and the mechanical environment. To optimize culture conditions, good understanding of these parameters is necessary. The new developments in bone biology, bone cell mechanotransduction, and cell-surface interactions are reviewed here to demonstrate that bone mechanotransduction is strongly influenced by the biomaterial properties.

  7. Bone tumors: Nursing care

    Bone tumors represent approximately 5% of childhood malignancies. osteosarcoma is the primary malignant bone tumor, accounting for 60% of cancer with peak incidence in the 2nd decade of life. Ewing's sarcoma is the second most common bone cancer with peak at a slightly younger age. This presentation discusses similarities and differences in the diagnosis and treatment of these two malignancies. Diagnostic procedures include plain radiographs, CT and MRI of the primary site, plain x-ray and CT of the chest, bone scan, and biopsy of the primary tumor. For patients diagnosed with Ewing's sarcoma, a bone marrow aspirate and biopsy will also be required. Our current approach to the treatment of bone tumors includes preoperative combination chemotherapy and en bloc surgical removal of the tumor followed by postoperative chemotherapy. In the case of Ewing's sarcoma, radiation therapy may be employed in addition to surgery, if margins are questionable of instead of surgery, if the tumor is not resectable

  8. Scintiscanning and bone tumors

    Bone scintigraphy in patients with primary bone cancers or metastases of other cancers is invaluable as a means of early detection and subsequent follow-up. The technique, which is becoming generalized involves the use of a 99m Tc-labelled phosphorated product and a digital image processing system. The method is constantly improving as new tumorotropic and osteotropic molecules are developed. These various aspects of bone scintigraphy (products used, apparatus, indications) are described briefly

  9. Triggered Star Formation in a Bright-rimmed Cloud (BRC 5) of IC 1805

    Fukuda, Naoya; Miao, Jingqi; Sugitani, Koji; Kawahara, Kentaro; Watanabe, Makoto; Nakano, Makoto; Pickles, Andrew J.

    2013-08-01

    We report recent optical, near-infrared (NIR), and millimeter observations which have revealed some new features of the bright-rimmed cloud BRC 5 associated with W4. With slitless spectroscopy, we detected 17 Hα emission stars around the cloud; 4 are near the surface of the cloud, and 1 is toward IRAS 02252+6120. NIR photometry shows that the central Hα emission star, together with one bright infrared source, has large NIR excesses and Class I spectral energy distributions. These two Class I objects are associated with the 2.9 mm continuum peaks and with a bipolar outflow, and are in between two separate, elongated C18O(J = 1-0) cores. The C18O cores and the two Class I sources are aligned along a line at position angle ~240°, somewhat less than perpendicular to the direction of UV radiation from the OB stars. Most of the detected Hα emission stars, all T Tauri candidates, are located within ~3' of the cloud on the exciting star side. An estimate of the age of the stars based on a color-magnitude diagram suggests that these T Tauri candidates have ages of ~1 Myr or less, but are more evolved objects than the central young stellar objects. This age sequence suggests sequential star formation within the BRC 5 cloud. The 13CO(J = 1-0) emission shows three elongated structures, which indicates the asymmetric structure toward the UV incident axis. We present our exploratory simulation results by using a smoothed particle hydrodynamic code that suggests that the asymmetrical BRC 5 structure could possibly result from the evolution of a preexisting prolate molecular cloud subject to radiation-driven implosion (RDI). Our best-fit prolate cloud has an initial mass of ~400 M ⊙, an axial ratio of ~1.7, and a semi-major axis of ~1.6 pc, pointing away from the ionization flux by an angle of 15°. The simulated cloud structure not only closely matches the observed asymmetric morphological structure of BRC 5, but also reveals the possibility of the development of two major cores at the head of BRC 5. For the first time, the possibility of forming two stars by an RDI mechanism in a BRC is investigated.

  10. TRIGGERED STAR FORMATION IN A BRIGHT-RIMMED CLOUD (BRC 5) OF IC 1805

    We report recent optical, near-infrared (NIR), and millimeter observations which have revealed some new features of the bright-rimmed cloud BRC 5 associated with W4. With slitless spectroscopy, we detected 17 Hα emission stars around the cloud; 4 are near the surface of the cloud, and 1 is toward IRAS 02252+6120. NIR photometry shows that the central Hα emission star, together with one bright infrared source, has large NIR excesses and Class I spectral energy distributions. These two Class I objects are associated with the 2.9 mm continuum peaks and with a bipolar outflow, and are in between two separate, elongated C18O(J = 1-0) cores. The C18O cores and the two Class I sources are aligned along a line at position angle ∼240°, somewhat less than perpendicular to the direction of UV radiation from the OB stars. Most of the detected Hα emission stars, all T Tauri candidates, are located within ∼3' of the cloud on the exciting star side. An estimate of the age of the stars based on a color-magnitude diagram suggests that these T Tauri candidates have ages of ∼1 Myr or less, but are more evolved objects than the central young stellar objects. This age sequence suggests sequential star formation within the BRC 5 cloud. The 13CO(J = 1-0) emission shows three elongated structures, which indicates the asymmetric structure toward the UV incident axis. We present our exploratory simulation results by using a smoothed particle hydrodynamic code that suggests that the asymmetrical BRC 5 structure could possibly result from the evolution of a preexisting prolate molecular cloud subject to radiation-driven implosion (RDI). Our best-fit prolate cloud has an initial mass of ∼400 M☉, an axial ratio of ∼1.7, and a semi-major axis of ∼1.6 pc, pointing away from the ionization flux by an angle of 15°. The simulated cloud structure not only closely matches the observed asymmetric morphological structure of BRC 5, but also reveals the possibility of the development of two major cores at the head of BRC 5. For the first time, the possibility of forming two stars by an RDI mechanism in a BRC is investigated

  11. TRIGGERED STAR FORMATION IN A BRIGHT-RIMMED CLOUD (BRC 5) OF IC 1805

    Fukuda, Naoya [Faculty of Biosphere-Geosphere Science, Okayama University of Science, 1-1 Ridai-chou, Okayama 700-0005 (Japan); Miao, Jingqi [Centre for Astrophysics and Planetary Science, School of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NR (United Kingdom); Sugitani, Koji [Graduate School of Natural Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-8501 (Japan); Kawahara, Kentaro [Faculty of Informatics, Okayama University of Science, 1-1 Ridai-chou, Okayama 700-0005 (Japan); Watanabe, Makoto [Department of Cosmosciences, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0810 (Japan); Nakano, Makoto [Faculty of Education and Welfare Science, Oita University, Oita 870-1192 (Japan); Pickles, Andrew J., E-mail: fukudany@big.ous.ac.jp [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Goleta, CA 93117 (United States)

    2013-08-20

    We report recent optical, near-infrared (NIR), and millimeter observations which have revealed some new features of the bright-rimmed cloud BRC 5 associated with W4. With slitless spectroscopy, we detected 17 H{alpha} emission stars around the cloud; 4 are near the surface of the cloud, and 1 is toward IRAS 02252+6120. NIR photometry shows that the central H{alpha} emission star, together with one bright infrared source, has large NIR excesses and Class I spectral energy distributions. These two Class I objects are associated with the 2.9 mm continuum peaks and with a bipolar outflow, and are in between two separate, elongated C{sup 18}O(J = 1-0) cores. The C{sup 18}O cores and the two Class I sources are aligned along a line at position angle {approx}240 Degree-Sign , somewhat less than perpendicular to the direction of UV radiation from the OB stars. Most of the detected H{alpha} emission stars, all T Tauri candidates, are located within {approx}3' of the cloud on the exciting star side. An estimate of the age of the stars based on a color-magnitude diagram suggests that these T Tauri candidates have ages of {approx}1 Myr or less, but are more evolved objects than the central young stellar objects. This age sequence suggests sequential star formation within the BRC 5 cloud. The {sup 13}CO(J = 1-0) emission shows three elongated structures, which indicates the asymmetric structure toward the UV incident axis. We present our exploratory simulation results by using a smoothed particle hydrodynamic code that suggests that the asymmetrical BRC 5 structure could possibly result from the evolution of a preexisting prolate molecular cloud subject to radiation-driven implosion (RDI). Our best-fit prolate cloud has an initial mass of {approx}400 M{sub Sun }, an axial ratio of {approx}1.7, and a semi-major axis of {approx}1.6 pc, pointing away from the ionization flux by an angle of 15 Degree-Sign . The simulated cloud structure not only closely matches the observed asymmetric morphological structure of BRC 5, but also reveals the possibility of the development of two major cores at the head of BRC 5. For the first time, the possibility of forming two stars by an RDI mechanism in a BRC is investigated.

  12. Rigidified calixarenes bearing four carbamoylmethylphosphineoxide or carbamoylmethylphosphoryl functions at the wide rim

    Arduini; Bohmer; Delmau; Desreux; Dozol; Carrera; Lambert; Musigmann; Pochini; Shivanyuk; Ugozzoli

    2000-06-16

    Conformationally rigidified tetraCMPO derivatives have been prepared from calix[4]arene bis(crown ether) 4a in which adjacent oxygens are bridged at the narrow rim by two diethylene glycol links. Acylation of the tetraamine 4c with the CMPO-active ester 5b gave the tetraphosphine oxide 6a, while the tetraphosphinate 6b and the tetraphosphonate 6c were obtained by Arbuzov reaction of tetrabromoacetamido derivative 7 with PhP(OEt)2 or P(OEt)3. The extraction ability of these CMPO derivatives was checked for selected lanthanides and actinides and compared with the analogous compounds 1b, 10b and 10d derived from calix[4]arene tetrapentyl ether. All rigidified bis(crown ether) ligands are more effective extractants than their pentyl ether counterparts and require only 1/10 of the concentration (cL= 10 4M) to obtain the same distribution coefficients, while with CMPO itself a 2,000-fold concentration is necessary. This could be a consequence of a better preorganisation of the ligating functions owing to the rigidity which on the other hand did not change the observed selectivity for americium (DAm/DEu=9-19) and for light lanthanides over heavy ones. NMR relaxivity titration curves show that the complex of Gd3+ with ligand 6a is highly oligomerised in anhydrous acetonitrile over a large range of ligand:metal concentration ratios. Nuclear magnetic relaxation dispersion (NMRD) profiles also showed that large oligomers were formed, and their mean tumbling times were deduced from the Solomon-Bloembergen-Morgan equations. The NMR spectra of dia- and paramagnetic lanthanide complexes with 6a agreed with the presence of two conformers with an elongated calix[4]arene skeleton in which the distances between opposite methylene groups are different. Contrary to what was observed with ligand 2a, the addition of nitrate ions does not labilize the metal complexes, presumably because of the rigidification effect of the ether bridges. Single-crystal X-ray structures were obtained for the active ester 5b and for diphenylphosphorylacetic acid 5a. PMID:10926218

  13. Computed tomographical findings of skeletal muscles in rimmed vacuole type distal myopathy

    Skeletal muscle CT scans of three patients with biopsy-proven rimmed vacuole type distal myopathy(RVDM) from two unrelated families showed unique involvement pattern of the lower extremities. Parents of the patients in both families are first cousins. T.Y. is a 36-year-old woman who noticed mild difficulty in walking at 34 years of age. Now she shows waddling but still indpendent gait. Manual muscle test (MMT) revealed the following results: fair (3+/5) for hip flexion, 3 for hip extension, 3 for knee flexion, normal (5/5) for knee extension, poor (2/5) for ankle dorsi-flexion, good (4/5) for ankle plantar flexion. T.M., a 34-year-old younger sister of T.Y., started dragging her feet on gait at age 27. She could walk neither on toes nor heels. At present, she can walk only with support. MMT showed the following: 3- and trace (1/5) for hip flexion and extension, 3- and 4 for knee flexion and extension, 1 for ankle plantar- and dorsiflexion. K.W., a 33-year-old woman, began to drag her foot tips in walk and became unable to walk on toes at age 21. The leg weakness progressed into the wheelchair-ridden state at age 30. MMT gave the following results: 1 for hip flexion and extension, 2 and 4 for knee flexion and extension, zero for plantar- and dorsi-flexion. The most impressive CT findings common to these three patients are prominent contrast between the quadriceps muscles and the adductor- and hamstring-group: the former is markedly well preserved even in the most advanced patient (K.W.) while the latter are diffusely and severely affected even in the least affected patient (T.Y.). This finding well coincides with the results of MMT: the knee extensor (quadriceps muscles) fairly well keeps its strength even in the most advanced patient but the knee flexors (adductors and hamstrings) are definitely affected in the early stage of the condition. (J.P.N.)

  14. Parosteal aneurysmal bone cyst☆

    Meohas, Walter; de Sá Lopes, Ana Cristina; da Silveira Möller, João Victor; Barbosa, Luma Duarte; Oliveira, Marcelo Bragança dos Reis

    2015-01-01

    The incidence of aneurysmal bone cysts is 0.14 cases per 100,000 individuals. Parosteal aneurysmal bone cysts are the least prevalent subtype and represent 7% of all aneurysmal bone cysts. We present the case of a 38-year-old male patient with pain and bulging in his right arm for eight months. He had previously been diagnosed as presenting giant-cell tumor, but his slides were reviewed and his condition was then diagnosed as parosteal aneurysmal bone cyst. The patient was treated with corticosteroid and calcitonin infiltration into the lesion and evolved with clinical and radiological improvement within the first five weeks after the operation. PMID:26535209

  15. Hypercalciuric Bone Disease

    Favus, Murray J.

    2008-09-01

    Hypercalciuria plays an important causal role in many patients with calcium oxalate (CaOx) stones. The source of the hypercalciuria includes increased intestinal Ca absorption and decreased renal tubule Ca reabsorption. In CaOx stone formers with idiopathic hypercalciuria (IH), Ca metabolic balance studies have revealed negative Ca balance and persistent hypercalciuria in the fasting state and during low dietary Ca intake. Bone resorption may also contribute to the high urine Ca excretion and increase the risk of bone loss. Indeed, low bone mass by DEXA scanning has been discovered in many IH patients. Thiazide diuretic agents reduce urine Ca excretion and may increase bone mineral density (BMD), thereby reducing fracture risk. Dietary Ca restriction that has been used unsuccessfully in the treatment of CaOx nephrolithiasis in the past may enhance negative Ca balance and accelerate bone loss. DEXA scans may demonstrate low BMD at the spine, hip, or forearm, with no predictable pattern. The unique pattern of bone histologic changes in IH differs from other causes of low DEXA bone density including postmenopausal osteoporosis, male hypogonadal osteoporosis, and glucocorticoid-induced osteoporosis. Hypercalciuria appears to play an important pathologic role in the development of low bone mass, and therefore correction of urine Ca losses should be a primary target for treatment of the bone disease accompanying IH.

  16. Bone marrow fat.

    Hardouin, Pierre; Pansini, Vittorio; Cortet, Bernard

    2014-07-01

    Bone marrow fat (BMF) results from an accumulation of fat cells within the bone marrow. Fat is not a simple filling tissue but is now considered as an actor within bone microenvironment. BMF is not comparable to other fat depots, as in subcutaneous or visceral tissues. Recent studies on bone marrow adipocytes have shown that they do not appear only as storage cells, but also as cells secreting adipokines, like leptin and adiponectin. Moreover bone marrow adipocytes share the same precursor with osteoblasts, the mesenchymal stem cell. It is now well established that high BMF is associated with weak bone mass in osteoporosis, especially during aging and anorexia nervosa. But numerous questions remain discussed: what is the precise phenotype of bone marrow adipocytes? What is the real function of BMF, and how does bone marrow adipocyte act on its environment? Is the increase of BMF during osteoporosis responsible for bone loss? Is BMF involved in other diseases? How to measure BMF in humans? A better understanding of BMF could allow to obtain new diagnostic tools for osteoporosis management, and could open major therapeutic perspectives. PMID:24703396

  17. Toxicokinetics of bone lead.

    Rabinowitz, M. B.

    1991-01-01

    This article discusses bone as a source of lead to the rest of the body and as a record of past lead exposure. Bone lead levels generally increase with age at rates dependent on the skeletal site and lead exposure. After occupational exposure, the slow decline in blood lead, a 5- to 19-year half-life, reflects the long skeletal half-life. Repeated measurements of bone lead demonstrate the slow elimination of lead from bone. Stable isotope ratios have revealed many details of skeletal uptake a...

  18. Distinct focal lesions of the femoral head: imaging features suggesting an atypical and minimal form of bone necrosis

    Heading AbstractObjective. To document the imaging findings observed in patients with an unusual pattern of abnormality of the femoral head, most likely representing osteonecrosis.Design and patients. The imaging findings in 11 patients (10 men, 1 woman; age range 32-55 years) with a distinct lesion of the femoral head were reviewed with particular attention to the morphologic appearance, location, and extent of the lesion(s) in the proximal femur.Results. The 16 lesions identified in these patients extended to the subchondral area. Articular collapse was not evident in any hip. Radiography and CT showed areas of mixed bone sclerosis and osteolysis surrounded by sclerotic margins. On MR imaging, the signal intensity characteristics of the osseous lesion(s) were most commonly similar to those of fluid. Histopathologic findings, available in two hips, were typical of osteonecrosis. There was evidence of correlation of the site of the lesion with the known general distribution and anastomoses of arteries supplying the femoral head.Conclusion. A distinct, focal lesion of the femoral head is believed to represent an atypical form of bone necrosis. Its restriction to a small portion of the femoral head may relate to localized vascular anatomy. Recognition of the quite characteristic imaging findings can prevent misdiagnosis and may have implications for the prediction of the natural course of the disease. (orig.)

  19. Multiple soft tissue aneurysmal cysts: An occurrence after resection of primary aneurysmal bone cyst of fibula

    Karkuzhali P

    2007-01-01

    Full Text Available We report a case of multiple extraosseous aneurysmal cysts occurring in the muscle and subcutaneous plane of postero-lateral aspects of the upper right leg. They appeared about 15 months after resection of aneurysmal bone cyst of the upper end of the fibula. They varied in size from 2 cm to 5 cm. Radiologically they were well-defined lesions with central septate areas surrounded by a rim of calcification. Histologically they showed central cystic spaces separated by septa consisting of fibroblasts, osteoclast type of giant cells and reactive woven bone. Thus they showed histological similarity with aneurysmal bone cysts, but did not show any connection with the bone. Only very few examples of aneurysmal cysts of soft tissue had been described in the past one decade and they were reported in various locations including rare sites such as arterial wall and larynx. Recent cytogenetic analyses have shown abnormalities involving 17p11-13 and/or 16q22 in both osseous and extraosseous aneurysmal cysts indicating its probable neoplastic nature. Our case had unique features like multiplicity and occurrence after resection of primary aneurysmal bone cyst of the underlying bone.

  20. Extraskeletal and intraskeletal new bone formation induced by demineralized bone matrix combined with bone marrow cells

    Dilutions of fresh autogenous bone marrow cells in combination with allogeneic demineralized cortical bone matrix were tested extraskeletally in rats using roentgenographic, histologic, and 45Ca techniques. Suspensions of bone marrow cells (especially diluted 1:2 with culture media) combined with demineralized cortical bone seemed to induce significantly more new bone than did demineralized bone, bone marrow, or composite grafts with whole bone marrow, respectively. In a short-term spinal fusion experiment, demineralized cortical bone combined with fresh bone marrow produced new bone and bridged the interspace between the spinous processes faster than other transplantation procedures. The induction of undifferentiated host cells by demineralized bone matrix is further complemented by addition of autogenous, especially slightly diluted, bone marrow cells

  1. Mimicking the nanostructure of bone matrix to regenerate bone

    Robert Kane; Peter X Ma

    2013-01-01

    Key features of bone tissue structure and composition are capable of directing cellular behavior toward the generation of new bone tissue. Bone tissue, as well as materials derived from bone, have a long and successful history of use as bone grafting materials. Recent developments in design and processing of synthetic scaffolding systems has allowed the replication of the bone's desirable biological activity in easy to fabricate polymeric materials with nano-scale features exposed on the surf...

  2. Subperiosteal ganglion associated with Paget's disease of bone

    Mansour, R.; Nanni, M.; Muthukumar, T.; Butt, S.H.; Cassar-Pullicino, V.N. [Robert Jones and Agnes Hunt Orthopaedic Hospital, Department of Radiology, Oswestry, Shropshire (United Kingdom)

    2005-07-01

    Tumoral lesions related to Paget's disease may be classified as malignant, benign or pseudotumoral. While sarcomatous degeneration is the most feared complication, awareness of benign and pseudotumoral lesions is essential for assisting in accurate histological interpretation of the biopsy sample, which may avoid unnecessary repeat biopsies. We present the first case of a juxta-articular subperiosteal ganglion associated with Paget's disease, with classic imaging characteristics, especially on CT examination. The well-defined soft tissue mass at the medial aspect of the obturator rim, adjacent to a small fracture in pagetic quadrilateral plate, showed an ossified rim and internal gas lucencies, these being the hallmarks of a juxta-articular subperiosteal ganglion. On MRI, the lesion was of intermediate signal intensity on T1-weighted sequences, increased signal intensity on T2-weighted sequences, with rim enhancement after gadolinium contrast injection and preservation of fatty marrow signal of the underlying pagetic bone. Identification of the entity avoided an unnecessary biopsy or surgical intervention. (orig.)

  3. Buyer's guide to telescopes at the best sites: Dome A, L2, and Shackleton Rim

    Angel, J. Roger P.

    2004-10-01

    Future optical/infrared telescopes will need to be much larger than today"s, if they are to address such key challenges as direct observations of Earth-like exoplanets and of the first stars formed after the big bang. In this paper I consider the most promising of the new sites, both on the ground and in space, and telescope concepts to take advantage of their complementary scientific potential. Ground based telescopes with adaptive optics will be capable of diffraction limited imaging, down to a short wavelength limit set by the amplitude and speed of the atmospheric turbulence. The best conditions are on the high Antarctic plateau, where recent measurements at Dome C show turbulence typically half the amplitude of the best temperate sites, with temporal evolution at half the speed1. Thus uniquely in Antarctica, diffraction limited imaging at optical wavelengths should be practical. Conditions there are also best for infrared astronomy, given the combination of minimal aberration and winter temperatures averaging as low as 200K at Dome A (the highest point). In space, well away from the warm Earth, conditions are even better, with 24 hour/day observing free from all atmospheric aberration, and the potential for passive cooling to 50K or less by use of a sunshield. L2 and the Moon's south pole are such optimal space locations. A telescope at L2 requires only a little fuel to stay on orbit, and can be accurately pointed despite solar torques by well established active methods based on star trackers, gyros and reaction wheels. By contrast, the Moon provides a completely stable platform where a telescope with no moving parts can remain pointed indefinitely along the spin axis, or a telescope on a hexapod mount can be oriented and tracked by reaction to the turning lunar surface. Solar shielding on the Moon requires a polar location such as the high rim of the Shackleton crater, adjacent to the south pole, where there is also nearly continuous solar power. Long term operation large telescopes in space should be possible at affordable cost if we adopt the strategy used on the ground, where the same telescope OTA and mount is maintained for decades while instruments are periodically upgraded. HST has already shown the power of this modus operandi in space. It makes sense because the optical image quality of any telescope cannot be improved once the diffraction limit is reached, while instruments need to be renewed to keep pace with scientific and technical developments. Thus if future space exploration results in long-term robotic or human infrastructure on the Moon, the Shackleton rim would be favored as an observatory site, especially for ultra-deep optical/infrared surveys. If, on the other hand, exploration is centered a new station in free space, out of the Earth's gravitational potential well, observatories at L2 would be more easily supported. When contrasting the performance of ground and space telescope options, an important trade is larger aperture on Earth versus lower background in space The thermal zodiacal background of space is typically 105 times lower than even the Antarctic background, and the optical scattered starlight background in space is much less, but because of the strong dependence of sensitivity on diameter a 100 m telescope at Dome A or Dome C would have sensitivity and power to study Earth-like planets comparable to that of NASA's proposed TPF coronagraphic and interferometric missions combined. For ultradeep field studies in the infrared, integration time is also important, thus a 20 m fixed telescope on the lunar south pole surveying just the south ecliptic pole region would have nearly 100 times the sensitivity of the JWST at L2. Neither Dome A nor the Moon"s south pole has yet been explored, even robotically. If large telescopes are ever to be built at these optimum sites, smaller precursors must be built first to develop the required technology and to gain experience. On the Moon, a start which would yield already interesting science could be made with a 3-m class, fixed, roboticall

  4. Resurfacing of the humeral head: An analysis of the bone stock and osseous integration under the implant.

    Schmidutz, Florian; Sprecher, Christoph M; Milz, Stefan; Gohlke, Frank; Hertel, Ralph; Braunstein, Volker

    2015-09-01

    Cementless-surface-replacement-arthroplasty (CSRA) of the shoulder aims for functional joint restoration with minimal bone loss. Good clinical results have been reported, but due to the radiopaque metal shell no data is available on the structure, osseous integration, and bone stock under the implant. 14 hemi-CSRAs (4 manufacturers) with two geometries (crown [n = 7]/ stem [n = 7] fixation) were retrieved from patients undergoing revision due to glenoidal erosion. Histological sections cutting through the implant centre and bone were analysed. Quantitative histomorphometry evaluated the bone-implant-contact and compared the bone-area to native humeral retrievals (n = 7). The bone-implant-interface was further assessed by scanning-electron-microscopy (SEM) and energy-dispersive-x-ray (EDX). Qualitative histology revealed a reduced and inhomogeneous bone stock. Obvious signs of stress shielding were observed with bone predominantly visible at the stem and implant rim. Quantitative histomorphometry confirmed the significantly reduced bone-area (9.2 ± 3.9% [crown 9.9 ± 4.3%, stem 8.6 ± 3.6%]) compared to native humeri (21.2 ± 9.1%; p < 0.05). Bone-implant-contact was 20.5 ± 5.8% (crown 21.8 ± 6.2%, stem 19.2 ± 5.6%) which was confirmed by SEM and EDX. Altogether, CRSA shows satisfactory bone ingrowth at the interface suggesting sufficient primary stability to allow osseous integration. However, clear signs of stress shielding with an inhomogeneous and reduced bone stock were observed. The impact on the long-term-results is unclear requiring further investigation. PMID:25808101

  5. Bone scintigraphy and densitometry in symptomatic haemodialysis bone disease

    Bone scintigraphy and densitometry (iodine-125 photon absorptiometry) were performed in eight patients with symptomatic haemodialysis bone disease. The bone scintiscan showed either hot spots or hyperactivity as a feature of metabolic bone disease. The bone density (BMC/W) was reduced, but could not be distinguished from the degree of demineralisation found in asymptomatic patients on longterm haemodialysis. Therefore, bone density measurements require critical interpretation. Complementary bone scintigraphy should be used in symptomatic haemodialysis bone disease for assessing the extent of the disease. (orig.)

  6. Bone scintigraphy and densitometry in symptomatic haemodialysis bone disease

    Alberts, C.; van der Schoot, J.B.; Busemann-Sokole, E.

    1981-11-01

    Bone scintigraphy and densitometry (iodine-125 photon absorptiometry) were performed in eight patients with symptomatic haemodialysis bone disease. The bone scintiscan showed either hot spots or hyperactivity as a feature of metabolic bone disease. The bone density (BMC/W) was reduced, but could not be distinguished from the degree of demineralisation found in asymptomatic patients on longterm haemodialysis. Therefore, bone density measurements require critical interpretation. Complementary bone scintigraphy should be used in symptomatic haemodialysis bone disease for assessing the extent of the disease.

  7. Evaluation of sequential FDG-PET/CT for monitoring bone metastasis of breast cancer during therapy. Correlation between morphological and metabolic changes with tumor markers

    The purpose of this study was to clarify the significance of positron emission tomography (PET) and computed tomography (CT) findings for evaluating the bone metastasis of breast cancer during therapy. Forty-seven patients with bone metastases from breast cancer who underwent sequential 18F-flourodeoxyglucose (FDG)-PET/CT studies during therapy were enrolled. A total of 771 lesions were identified. The changes in the PET and CT findings were compared with the tumor marker levels in each patient by calculating the weighted kappa value. The correlation between the PET and CT findings was examined for each lesion by an adjusted Chi-square test. The change in the tumor marker levels was substantially correlated with the PET findings and moderately correlated with the CT findings (weighted kappa=0.780 and 0.585 for quadratic weighting, respectively). An increase in FDG uptake was correlated with lytic changes on the CT images (62/65, 95.4%, p<0.05). Sclerotic changes suggested improvement, but sclerosis and progression occurred at the same time in some lesions. Changes of FDG uptake are useful for evaluating individual bone metastases in cases of breast cancer during therapy. Lytic change on CT images suggests progression of bone metastasis. The lysis-progression/sclerosis-improvement pattern was observed in the majority of subjects, but a sclerosis-progression pattern was also observed. The hybrid pattern of increase of FDG uptake on PET/lytic change on CT is most accurate to show progression of bone metastases. Assessments of these processes during therapy are necessary for the precise evaluation of bone metastases. (author)

  8. Bone X-Ray (Radiography)

    Full Text Available ... is commonly used to diagnose fractured bones or joint dislocation. Bone x-rays are the fastest and ... to view and assess bone fractures, injuries and joint abnormalities. This exam requires little to no special ...

  9. Bone X-Ray (Radiography)

    Full Text Available ... of bone cancer . locate foreign objects in soft tissues around or in bones. top of page How ... bone absorbs much of the radiation while soft tissue, such as muscle, fat and organs, allow more ...

  10. Healthy Bones at Every Age

    ... even be reversed with newer, bone-forming medications. Gender and Peak Bone Mass Men have a higher ... with the peak bone mass someone your same gender and ethnicity should have reached at 20 to ...

  11. In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies

    SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. In order to identify the sites where SUMOylation takes place in the cell, we developed an in situ SUMOylation assay using a semi-intact cell system and subsequently combined it with siRNA-based knockdown of nucleoporin RanBP2, also known as Nup358, which is one of the known SUMO E3 proteins. With the in situ SUMOylation assay, we found that both nuclear rim and PML bodies, besides mitotic apparatuses, are major targets for active SUMOylation. The ability to analyze possible SUMO conjugation sites would be a valuable tool to investigate where SUMO E3-like activities and/or SUMO substrates exist in the cell. Specific knockdown of RanBP2 completely abolished SUMOylation along the nuclear rim and dislocated RanGAP1 from the nuclear pore complexes. Interestingly, the loss of RanBP2 markedly reduced the number of PML bodies, in contrast to other, normal-appearing nuclear compartments including the nuclear lamina, nucleolus and chromatin, suggesting a novel link between RanBP2 and PML bodies. SUMOylation facilitated by RanBP2 at the nuclear rim may be a key step for the formation of a particular subnuclear organization. Our data imply that SUMO E3 proteins like RanBP2 facilitate spatio-temporal SUMOylation for certain nuclear structure and function

  12. Star formation in bright-rimmed clouds and clusters associated with the W5 E H II region

    Chauhan, Neelam; Pandey, A. K.; Ogura, K.; Jose, J.; Ojha, D. K.; Samal, M. R.; Mito, H.

    2011-08-01

    The aim of this paper is to present the results of photometric investigations of the central cluster of the W5 E H II region as well as a follow-up study of the triggered star formation in and around bright-rimmed clouds (BRCs). We have carried out wide-field UBVIC and deep VIC photometry of the W5 E H II region. A distance of ˜2.1 kpc and a mean age of ˜1.3 Myr have been obtained for the central cluster. The young stellar objects (YSOs) associated with the region are identified on the basis of near-infrared and mid-infrared observations. We confirmed our earlier results that the average age of the YSOs lying on/inside the rim is younger than those lying outside the rim. The global distribution of the YSOs shows an aligned distribution from the ionizing source to the BRCs. These facts indicate that a series of radiation-driven implosion processes proceeded from near the central ionizing source towards the periphery of the W5 E H II region. We found that, in general, the age distributions of the Class II and Class III sources are the same. This result is apparently in contradiction to the conclusion by Bertout, Siess & Cabrit and Chauhan et al. that classical T Tauri stars evolve to weak-line T Tauri stars. The initial mass function of the central cluster region in the mass range 0.4 ≤M/M⊙≤ 30 can be represented by Γ=-1.29 ± 0.04. The cumulative mass functions indicate that in the mass range 0.2 ≤M/M⊙≤ 0.8, the cluster region and BRC NW have more low-mass YSOs compared to BRCs 13 and 14.

  13. Timescales and mechanisms of REE and Hf uptake in fossil bones

    Herwartz, Daniel; Tütken, Thomas; Münker, Carsten; Jochum, Klaus Peter; Stoll, Brigitte; Sander, P. Martin

    2011-01-01

    Rare earth element (REE) patterns of fossil bones and teeth are widely used as proxies for provenance, taphonomy, and palaeoenvironment. In order to investigate if fossil bones behave as closed systems over geologic time, REE profiles were analysed by LA-ICPMS along cross sections of 54 bones from various well-characterised and well-dated settings. These include terrestrial and marine diagenetic environments, covering Early Triassic to Holocene ages. In general, all fossil bones exhibit the highest REE concentrations at the outer rim, gradually decreasing by up to four orders of magnitude toward the inner bone cortex. Intra-bone REE concentration gradients decrease significantly from Quaternary via Tertiary to Mesozoic specimens, suggesting long term REE uptake and open system behaviour of fossil bone. This view is further corroborated by 176Lu- 176Hf dating of selected samples, all yielding significantly younger ages than the known chronostratigraphic ages. Hence, there is clear evidence for long term open system behaviour of fossil bones with respect to REE, which is in marked contrast to currently accepted models suggesting that REE uptake is only early diagenetic. Although unexpected, statistically significant four to seven point isochrons are observed for four fossil dinosaur bone samples and one Upper Triassic Mastodonsaurus tooth with MSWDs ranging from 0.083 to 4.5. Notably, mobility of Lu alone cannot account for the observed age patterns. Assuming constant Lu uptake rates over time, the radiometric ages should only be as low as half of the chronostratigraphic age. However, a six-point isochron defined by subsamples of a single Upper Triassic Mastodonsaurus tooth yields an age of 65.2 ± 1.1 Ma (MSWD = 0.68), much younger than half of the stratigraphic age (ca. 234 Ma). Hence, Hf must also undergo late diagenetic exchange. Likely mechanisms to account for the presence of statistically meaningful isochrons as well as for the late diagenetic exchange of both REE and Hf are diffusion, adsorption, and dissolution-reprecipitation processes.

  14. Gentamicin in bone cement

    Chang, Y; Tai, C-L.; Hsieh, P-H.; Ueng, S. W. N.

    2013-01-01

    Objectives The objective of this study is to determine an optimal antibiotic-loaded bone cement (ALBC) for infection prophylaxis in total joint arthroplasty (TJA). Methods We evaluated the antibacterial effects of polymethylmethacrylate (PMMA) bone cements loaded with vancomycin, teicoplanin, ceftazidime, imipenem, piperacillin, gentamicin, and tobramycin against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staph. aureus (MRSA), coagulase-negative staphylococci (C...

  15. Bone marrow transplantation

    Peculiarities of clinico-hematologic pattern in patients with acute leukosis when ionizing radiation is used as prepration regime for hystocompatible bone marrow transplantation are listed. Chemico-radiopreparation of patients with acute leukosis is described, different techniques of bone marrow transplantation are presented, secondary signs of the disease are shown

  16. Hyperparathyroidism and Bone Health.

    Bandeira, Francisco; Cassibba, Sara

    2015-07-01

    Bone pain, proximal muscle weakness, skeletal deformities, and pathological fractures are features of osteitis fibrosa cystica which occur in severe primary hyperparathyroidism (PHPT). In this condition, bone mineral density is usually extremely low, but may be reversible after parathyroidectomy. On X-ray, bone abnormalities are described as having a salt-and-pepper appearance in the skull, with bone erosions and resorption of the phalanges, brown tumors and cysts, as well as diffuse demineralization, along with pathological fractures, particularly in the long bones of the extremities. A marked elevation of the serum calcium and PTH concentrations is seen, and renal involvement is manifested by nephrolithiasis and nephrocalcinosis. In asymptomatic PHPT, the absence of clinically significant bone involvement has led to much more data on bone mineral density becoming available by dual X-ray absorptiometry (DXA) and also on new technologies such as trabecular bone score (TBS), which is a gray-level textural analysis of DXA images that provides an indirect index of trabecular microarchitecture. In addition, high-resolution peripheral computed tomography (HRpQCT), which has a low radiation exposure, provides further understanding of the microstructural skeletal features at both trabecular and cortical sites. PMID:26105042

  17. Biodegradable synthetic bone composites

    Liu, Gao; Zhao, Dacheng; Saiz, Eduardo; Tomsia, Antoni P.

    2013-01-01

    The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

  18. Bone Mineral Measurements.

    Doroudinia, Abtin; Colletti, Patrick M

    2015-08-01

    The accurate measurement of bone mineral density using noninvasive methods can be of value in the detection and evaluation of primary and secondary causes of decreased bone mass. This includes primary osteoporosis and secondary disorders, such as hyperparathyroidism, osteomalacia, multiple myeloma, diffuse metastases, and glucocorticoid therapy or intrinsic excess.By far, the largest patient population is that encompassed by primary osteoporosis with increased susceptibility to fractures in the absence of other recognizable causes of bone loss.Primary osteoporosis is a common clinical disorder and a major public health problem because of the significant number of related bone fractures occurring annually. Because the risk of vertebral and femoral neck fractures rises dramatically as bone mineral density falls, fracture risk in individual patients may be estimated. Furthermore, in estrogen-deficient women, bone mineral density values may be used to make rational decisions about hormone replacement therapy, or other bone mineral therapies, and as follow-up in assessing the success of such treatment.In this article, we discuss different methods of bone densitometry and will focus on dual-energy x-ray absorptiometry (DXA) with discussing the factors which should be considered for interpretation of DXA scan. PMID:26147459

  19. Proximal Tibial Bone Graft

    ... much graft is needed for the patient’s foot/ankle. Two types of bone can be taken from the proximal ... which the bone was taken if the foot/ankle surgeries done at the same time allow for it. ... problems after a PTBG include infection, fracture of the proximal tibia and pain related to ...

  20. Wnt Signaling in Bone

    Kubota, Takuo; Michigami, Toshimi; Ozono, Keiichi

    2010-01-01

    Wnt signaling is involved not only in embryonic development but also in maintenance of homeostasis in postnatal tissues. Multiple lines of evidence have increased understanding of the roles of Wnt signaling in bone since mutations in the LRP5 gene were identified in human bone diseases. Canonical Wnt signaling promotes mesenchymal progenitor cells to differentiate into osteoblasts. The canonical Wnt/β-catenin pathway possibly through Lrp6, a co-receptor for Wnts as well as Lrp5, in osteoblasts regulates bone resorption by increasing the OPG/RANKL ratio. However, endogenous inhibitors of Wnt signaling including sclerostin block bone formation. Regulation of sclerostin appears to be one of the mechanisms of PTH anabolic actions on bone. Since sclerostin is almost exclusively expressed in osteocytes, inhibition of sclerostin is the most promising design. Surprisingly, Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum, but not by directly promoting bone formation. Pharmacological intervention may be considered in many components of the canonical Wnt signaling pathway, although adverse effects and tumorigenicity to other tissues are important. More studies will be needed to fully understand how the Wnt signaling pathway actually influences bone metabolism and to assure the safety of new interventions. PMID:23926379

  1. Computer Calculations of Eddy-Current Power Loss in Rotating Titanium Wheels and Rims in Localized Axial Magnetic Fields

    Mayhall, D J; Stein, W; Gronberg, J B

    2006-05-15

    We have performed preliminary computer-based, transient, magnetostatic calculations of the eddy-current power loss in rotating titanium-alloy and aluminum wheels and wheel rims in the predominantly axially-directed, steady magnetic fields of two small, solenoidal coils. These calculations have been undertaken to assess the eddy-current power loss in various possible International Linear Collider (ILC) positron target wheels. They have also been done to validate the simulation code module against known results published in the literature. The commercially available software package used in these calculations is the Maxwell 3D, Version 10, Transient Module from the Ansoft Corporation.

  2. Airborne measurements and emission estimates of greenhouse gases and other trace constituents from the 2013 California Yosemite Rim wildfire

    Yates, E. L.; Iraci, L. T.; Singh, H. B.; Tanaka, T.; Roby, M. C.; Hamill, P.; Clements, C. B.; Lareau, N.; Contezac, J.; Blake, D. R.; Simpson, I. J.; Wisthaler, A.; Mikoviny, T.; Diskin, G. S.; Beyersdorf, A. J.; Choi, Y.; Ryerson, T. B.; Jimenez, J. L.; Campuzano-Jost, P.; Loewenstein, M.; Gore, W.

    2016-02-01

    This paper presents airborne measurements of multiple atmospheric trace constituents including greenhouse gases (such as CO2, CH4, O3) and biomass burning tracers (such as CO, CH3CN) downwind of an exceptionally large wildfire. In summer 2013, the Rim wildfire, ignited just west of the Yosemite National Park, California, and burned over 250,000 acres of the forest during the 2-month period (17 August to 24 October) before it was extinguished. The Rim wildfire plume was intercepted by flights carried out by the NASA Ames Alpha Jet Atmospheric eXperiment (AJAX) on 29 August and the NASA DC-8, as part of SEAC4RS (Studies of Emissions, Atmospheric Composition, Clouds and Climate Coupling by Regional Surveys), on 26 and 27 August during its intense, primary burning period. AJAX revisited the wildfire on 10 September when the conditions were increasingly smoldering, with slower growth. The more extensive payload of the DC-8 helped to bridge key measurements that were not available as part of AJAX (e. g. CO). Data analyses are presented in terms of emission ratios (ER), emission factors (EF) and combustion efficiency and are compared with previous wildfire studies. ERs were 8.0 ppb CH4 (ppm CO2)-1 on 26 August, 6.5 ppb CH4 (ppm CO2)-1 on 29 August and 18.3 ppb CH4 (ppm CO2)-1 on 10 September 2013. The increase in CH4 ER from 6.5 to 8.0 ppb CH4 (ppm CO2)-1 during the primary burning period to 18.3 ppb CH4 (ppm CO2)-1 during the fire's slower growth period likely indicates enhanced CH4 emissions from increased smoldering combustion relative to flaming combustion. Given the magnitude of the Rim wildfire, the impacts it had on regional air quality and the limited sampling of wildfire emissions in the western United States to date, this study provides a valuable dataset to support forestry and regional air quality management, including observations of ERs of a wide number of species from the Rim wildfire.

  3. The application and implementation of optimized mine ventilation on demand (OMVOD) at the Xstrata Nickel Rim South Mine, Sudbury, Ontario

    An Optimized Mine Ventilation on Demand (OMVOD) system has been installed at the Xstrata Nickel Rim South Mine in Sudbury. Developed by Simsmart Technologies, the OMVOD system monitors and controls air quality and quantity through real time dynamic automation. A ventilation on demand (VOD) system was needed to remove diesel particulate matter (DPM), carbon monoxide (CO) and nitrogen dioxide (NO2). This paper described the real-time tracking and monitoring of the OMVOD system and optimization of ventilation equipment. Simsmart's OMVOD system was shown to reduce energy costs while improve air quality in the underground mine. 7 refs., 3 tabs., 8 figs.

  4. Design optimization of a slotless PM brushless motor with helical edge wound laminations for rim driven thrusters

    Sharkh, S.M.; Lai, S. H.

    2010-01-01

    This paper discusses the analysis and design of a very thin slotless PM brushless motor whose stator laminations are manufactured from a single strip of steel that is edge wound into a spiral (like a “Slinky”) and then fitted over the windings that are preformed on the outside surface of a non-conducting former. Analytical and finite element analysis (FEA) are used to determine the constrained optimum dimensions of a motor used to drive a rim driven thruster in which the motor rotor is fitted...

  5. Orthopyroxene rim growth between olivine and quartz at low temperatures (750-950°C) and low water concentration

    Milke, Ralf; Kolzer, Kornelia; Koch-Müller, Monika; Wunder, Bernd

    2009-12-01

    Orthopyroxene reaction rims were synthesized between polished plates of natural olivine or synthetic forsterite and quartz at 1.9 GPa and temperatures of 750-950°C. The experiments were performed in a piston-cylinder apparatus after drying the samples at 600°C. Each experiment comprised 4 or 7 quartz-olivine contacts that were positioned along a temperature gradient. As a monitor for water content in the samples, the water concentration in the two olivines was determined by FTIR before and after the experiments. The orthopyroxene layers show two different structural variants. Type one (normal layers) has very constant thickness at each contact and formed with equal growth rates at both interfaces. Type two (bulging layers) comprises more irregular areas with 3-5 times thicker rims where porosity provides evidence for the local presence of a fluid. In the bulging layers the growth rate at the olivine-orthopyroxene interface exceeds that at the quartz-orthopyroxene interface. The relative growth rates at the interfaces are in accordance with SiO2-immobile growth of the normal layers and SiO2-mobile growth of the bulging layers. The natural olivine contains about 60 wt-ppm intracrystalline water before and after experiment and took up about 20 wt-ppm water molecular adsorbed to micro- and nanocracks and -pores during the runs. The synthetic forsterite contains about 7 wt-ppm internally adsorbed molecular water before and after experiment, and during the runs took up hydrogen equivalent to 3 wt-ppm adsorbed water. The IR spectra indicate that large parts of the point defects (possibly tetrahedral) were frozen-in at the conditions of the experiments. In both olivines a new band appeared at 3,355 or 3,357 cm-1, respectively, equivalent to about 3 wt-ppm water that at the high pressure of the experiments and opx-buffered aSiO2 of the experiments might already mean water saturation of the olivines. Despite the effective drying before experiment and the absence of porosity, the bulk diffusivity derived from the rim growth rates is perfectly in line with data from water-bearing piston-cylinder experiments at higher temperatures. The bulk diffusivity during rim growth is 4 to 7 orders of magnitude higher than an extrapolation of really dry experiments to the temperature range of this study.

  6. Temporal bone CT findings of tuberculous otitis media : comparison with chronic otitis media

    To compare the differential findings of tuberculous otitis media(TOM) with those of chronic sup purative otitis media with or without cholesteatoma, as seen on high resolution temporal bone CT. We retrospectively reviewed 14 cases of TOM, 30 cases of chronic suppurative otitis media(CSOM), and 30 cases of chronic otitis media with cholesteatoma(Chole). All had been pathologically confirmed. We evaluated the preservation of mastoid cells without sclerotic change, the location and extension of soft tissue to the external auditary canal, and erosion of ossicles, the tegmen tympani, scutum, bony labyrinth, facial nerve canal and sigmoid sinus, and the presence of intracranial complications. Soft tissue in the mastoid antrum was seen in all cases of TOM(100%), 29 cases of CSOM(96.7%), and 26 cases of Chole(86.7%). In contrast, the soft tissue in the entire middle ear cavity was noted in 13 cases of TOM(92.8%), 7 cases of CSOM(23.3%), and 12 cases of Chole(40%). Soft tissue extended to the superior aspect of the external auditory canal in 4 cases of TOM (28.6%) and 5 cases of Chole (16.7%). Mastoid air cells were seen in 9 cases of TOM (64.3%), 4 cases of CSOM (13.3%), and 3 cases of Chole(10%). Ossicular erosion was noted in 6 cases of TOM (42.9%), 12 cases of CSOM (40%), and 26 cases of Chole(86.7%), while in one case of TOM (7.1%), 5 cases of CSOM (16.7%), and 15 cases of Chole(50%) there was erosion of the scutum. In one case of TOM, follow-up CT study after 9 months of antituberculous medication without surgery revealed complete clearing of previously noted soft tissue in the middle ear cavity. Specific CT findings of TOM were not seen, but if there were findings of soft tissue in the entire middle ear cavity, soft tissue extension to the external auditory canal, preservation of mastoid air cells without sclerotic change, and intact scutum, TOM may be differentiated from other chronic otitis media

  7. The normal bone scan

    This paper discusses applications of the bone scan. It is the most frequently performed nuclear medicine investigation, the commonest indication being the detection of occult metastases, for which purpose the entire skeleton should be imaged. For other purposes it is often adequate to examine only part of the skeleton. The amount of isotope taken up at any site depends primarily on the local rate of bone turnover rather than on bone mass. The scintigraphic appearance therefore does not necessarily correlate with the radiographic one; however, as there is a relationship between the rate at which bone is replaced and the quantity of bone which is present at any point, the two appearances are not entirely unrelated. Recognition of abnormality is based on a detailed knowledge of normal scintigraphic appearances

  8. The petrous bone

    Jørkov, Marie Louise Schjellerup; Heinemeier, Jan; Lynnerup, Niels

    2009-01-01

    Intraskeletal variation in the composition of carbon (delta(13)C) and nitrogen (delta(15)N) stable isotopes measured in collagen is tested from various human bones and dentine. Samples were taken from the femur, rib, and petrous part of the temporal bone from well-preserved skeletons of both adults...... (n = 34) and subadults (n = 24). Additional samples of dentine from the root of 1st molars were taken from 16 individuals. The skeletal material is from a medieval cemetery (AD 1200-1573) in Holbaek, Denmark. Our results indicate that the petrous bone has an isotopic signal that differs significantly...... this study it is believed the petrous bone may be a new useful bone element and a supplement or a proxy for teeth in the analysis of early dietary patterns as it may reflect diet in fetal stages and early years of life....

  9. Mechanical optimization of bone.

    Chigira, M

    1996-04-01

    In bending, the mechanical strength of tubular bone can be estimated by the area moment of inertia (I) = 1/4 x pi x (R4 - r4) (R: external radius, and r: internal radius). Mechanical strength of bone is dissociated from bone density, since radiological density is different from inertia. When the cross-sectional area is constant (C = R2 - r2) in this equation, inertia can be expressed by the equation of (I) = 1/4 x pi x (2Cr2 + C2). Inertia increases with increases of the external and internal radii. According to the above equation, increase of inertia depending on the expansion of radii is inevitable 'optimization' of bone mass. Expansion of the radii of tubular bone with the decrease of wall thickness is an adaptation process rather than the 'decompensation' called osteoporosis. Senescence of individuals as manifested in conditions such as osteoporosis is a stampede of adaptations rather than decompensation of it. PMID:8733159

  10. Bone and Celiac Disease.

    Zanchetta, María Belén; Longobardi, Vanesa; Bai, Julio César

    2016-04-01

    More than 50 % of untreated patients with celiac disease (CD) have bone loss detected by bone densitometry (dual-energy X-ray absorptiometry:DXA). Moreover, patients with CD are more likely to have osteoporosis and fragility fractures, especially of the distal radius. Although still controversial, we recommend DXA screening in all celiac disease patients, particularly in those with symptomatic CD at diagnosis and in those who present risk factors for fracture such as older age, menopausal status, previous fracture history, and familial hip fracture history. Bone microarchitecture, especially the trabecular network, may be deteriorated, explaining the higher fracture risk in these patients. Adequate calcium and vitamin D supplementation are also recommended to optimize bone recovery, especially during the first years of gluten free diet (GFD). If higher fracture risk persists after 1 or 2 years of GFD, specific osteoactive treatment may be necessary to improve bone health. PMID:26875096

  11. Bone markers and osteoporosis therapy

    Francisco Bandeira

    2014-07-01

    Full Text Available Several factors are involved in determining bone quality including bone density, bone turnover, the extent of trabecular bone connectivity, cortical porosity and geometry. Metabolically active and in a continuous process of remodeling, approximately 20% of bone tissue is renewed annually. Bone turn over markers (BTM are frequently used in clinical trials and to provide valid information about the effectiveness of osteoporosis treatment, reflecting the state of bone metabolism and its response to treatment, although they are not useful alone to estimate bone loss. In this review the behavior of BTM from different clinical trials or different osteoporotic drugs will be addressed.

  12. Bone scanning in osteoporosis

    This paper reports on bone scanning in osteoporosis a diagnosis of osteoporosis most often follows fracture, and clearly this should be confirmed by x-ray. The bone scan therefore does not have an important role to play in the initial diagnosis of osteoporosis. While the exact mechanism by which the 99mTc-labeled diphosphonates localize in the skeleton is not fully understood, it is believed that they adsorb onto bone surfaces most probably via the calcium of hydroxyapatite crystals. Because the major factors that affect adsorption are osteoblastic activity and to a lesser extent skeletal vascularity, it is apparent that a bone scan image presents a functional display of skeletal metabolic activity. However, osteoporosis is a disorder in which gradual change in bone mass may occur over many years and, in keeping with this minor imbalance in skeletal metabolism, the bone scan appearances are usually normal. However, the scan images may appear of poor quality because of relatively low bone uptake of tracer with, on occasion, a washed-out pattern of activity in the axial and appendicular bone. It has been suggested that such a pattern occurs in severe or end-stage osteoporosis caused by markedly reduced osteoblastic activity. If kyphosis is observed on the bone scan or if there appears to be loss of spinal height with proximity of ribs to each other or increased closeness of rib cage to pelvis, then appearances suggest vertebral collapse and would be in keeping with a diagnosis of osteoporosis. Such evidence is, however, indirect and in practice a bone scan is an extremely unreliable means of diagnosing osteoporosis

  13. Ultratrace analysis of long-lived radionuclides by resonance ionization mass spectrometry (RIMS)

    For long-lived radionuclides such as actinides, conventional radioanalyses by α spectroscopy suffer from unsatisfactory limits of detection (LOD). Resonance ionization mass spectrometry, on the contrary, achieves limits of detection of 106 atoms and is free from isobaric interferences. The multiple step resonant excitation of evaporated atoms with laser light and the mass selective detection is presented for isotopes of plutonium as an example. We use a frequency-doubled Nd:YAG laser with a repetition rate of 10 kHz to pump three titanium-sapphire lasers delivering wave lengths of 420.76 nm, 847.28 nm, and 767.53 nm to resonantly excite plutonium into a Rydberg state from where ionization is achieved by applying an electric field. For isotopic composition measurements, the wavelengths of lasers 1 and 2 must be readjusted for each isotope while laser 3 can be maintained at the same wavelength. The accuracy of isotopic ratios determined this way is demonstrated with a certified NIST standard. Applications are presented for fallout plutonium, reactor plutonium, samples from the Chernobyl area, wapons plutonium from the Mururoa island, seawater plutonium from the Northern Sea, and from the Irish Sea. Migration of plutonium through a granite fracture in the Grimsel underground laboratory has also been investigated. By detecting ionization thresholds as a function of the applied electric field, accurate ionization potentials IP of Ac, Th, U, Np, Pu, Am, Cm, Bk, Cf, and Es have been determined by extrapolation to zero field strength. In a first attempt to determine also the IP of Fm, a sample of 20.1-h 255Fm produced at the HFIR at Oak Ridge has been investigated. By resonance excitation with a dye laser and ionization with an excimer laser in a buffer gas cell, two excited states of Fm (5f12 7s 7p) have been identified and mass spectra of 255Fm+ and the daughter 251Cf+ have been measured by a quadrupole mass spectrometer coupled to a channeltron detector. By measuring the drift times of these ions and of 238UO+, ion mobilities in the electric field could be determined. These are potentially useful to determine ionic radii of the heavy actinides and superheavy elements. By using a commercial IONTOF-SIMS apparatus, analyses of hot micro particles with high lateral resolution in the sub-micron range have been exploited. For the determination of the location of these hot particles (x,y coordinate on the target holder) their content of fissile material via fission track analysis has been used. In order to avoid isobaric interferences, the sputtered ions (SIMS) were suppressed by a pulsed counter voltage applied to the target holder, and the abundantly sputtered neutral particles were resonantly excited and ionized by RIMS. The resulting ions were directed by an alternating acceleration voltage into the TOF mass spectrometer. (author)

  14. 2011 Tohoku Earthquake and Japan's Nuclear Disaster - Implications for Indian Ocean Rim countries

    Chadha, R. K.

    2011-12-01

    The Nuclear disaster in Japan after the M9.0 Tohoku earthquake on March 11, 2011 has elicited global response to have a relook at the safety aspects of the nuclear power plants from all angles including natural hazards like earthquakes and tsunami. Several countries have gone into safety audits of their nuclear programs in view of the experience in Japan. Tectonically speaking, countries located close to subduction zones or in direct line of impact of the subduction zones are the most vulnerable to earthquake or tsunami hazard, as these regions are the locale of great tsunamigenic earthquakes. The Japan disaster has also cautioned to the possibility of great impact to the critical structures along the coasts due to other ocean processes caused by ocean-atmosphere interactions and also due to global warming and sea level rise phenomena in future. This is particular true for island countries. The 2011 Tohoku earthquake in Japan will be remembered more because of its nuclear tragedy and tsunami rather than the earthquake itself. The disaster happened as a direct impact of a tsunami generated by the earthquake 130 km off the coast of Sendai in the Honshu region of Japan. The depth of the earthquake was about 25 km below the ocean floor and it occurred on a thrust fault causing a displacement of more than 20 meters. At few places, water is reported to have inundated areas up to 8-10 km inland. The height of the tsunami varied between 10 and 3 meters along the coast. Generally, during an earthquake damage to buildings or other structures occur due to strong shaking which is expressed in the form of ground accelerations 'g'. Although, Peak Ground Accelerations (PGA) consistently exceeded 2g at several places from Sendai down south, structures at the Fukushima Daiichi Nuclear Power Plant did not collapse due to the earthquake. In the Indian Ocean Rim countries, Indian, Pakistan and South Africa are the three countries where Nuclear power plants are operational, few of them along the coasts. There are a few countries where nuclear installations are planned and hence, a critical analysis is required to know the realistic hazard due to earthquakes and tsunami in these countries. The December 2004 Indian Ocean tsunami generated due to Sumatra earthquake of M9.3 claimed more than 250,000 lives but did not caused a situation like in Japan. We studied the tsunami run-up heights and inundation along the east coast of India. The maximum run-up height of 5.2 meters was observed at Nagapattinam with lateral inundation up to 800 meters and the minimum was at Devanaampatnam with a lateral inundation up to 340 meters. At Kalpakkam Nuclear Power Plant, the tsunami run-up height was 4.1 meters and water entered up to 360 meters inside the campus. Using the observed data we modeled several scenarios for Indian coast line for different earthquakes along the subduction zone of Andaman-Sumatra in the east and Makran in south Pakistan in the western side using N2 Tsunami Model. The results obtained for few critical structures will be presented with an overview of scenarios for other countries.

  15. A CLINICAL STUDY ON LENS INDUCED GLAUCOMA AND ITS VISUAL OUTCOME IN PATIENTS VISITING RIMS, SRIKAKULAM

    Rajkumar

    2015-07-01

    Full Text Available AIM: To Evaluate sex predominance, prevalence of different types of lens induced Glaucomas and its visual outcomes in patients visiting rims, srikakulam. MATERIAL AND METHODS : This prospective study was conducted in Ophthalmology department of Rajiv Gandhi Institute of Medical Sciences, Srikakulam, Andhra Pradesh from October 2014 to June 2015. 37 Patients visiting the Hospital with classical symptoms of Lens induced Glaucoma were taken into study. First all these patients underwent a through ocular examination using Slit lamp biomicroscopy, Schiotz tonometry and Applanation tonometer. T hese patients were operated after explaining the possible prognosis, by Small Incision Cataract Surgery with PCIOL implantation. Also a peripheral Iridectomy was performed to all the patients. Post operatively immense care was taken to prevent posterior synechiae formation using short acting Cycloplegics. During follow up a detailed Ocular examination was done including Refraction using snellens chart and IOP measurement using Schiotz tonometer and applanation tomometer. All the results were entered in Computer and evaluated. RESULTS: A Total of 37 patients were taken into this study in which 14(37.84% were male patients and 23(62.16% were Female. Among different LIG patients maximum patients had Phacomorphic Glaucoma accounting 67.57% (25 patients and Phacolytic Glaucoma 29.73%. Intra Ocular pressure was measured on admission before any medication and noted. Highest percentage was among 30 - 39mmHg (37.84% followed by 40 - 49mmHg (32.43% and 50 - 59mmHg (16.22%. After surgery during discharge all those patients were measured again for IOP and noted. Highest patients were between 10 - 19mmHg (78.38%. Rest were <10(10.8%. Similarly Visual acuity o n admission, highest patients were seen in Hand movements positive (37.84% followed by Perception of Light positive (29.73%. Even No PL were also seen (16.22% in higher proportion. On the day of follow up after 2 weeks of surgery, maximum patients were seen between 6/12 - 6/18(35.14% followed by 6/24 - 6/36 (21.6% and 6/6 - 6/9 (18.9%. CONCLUSION: LIG is an important vision - threatening disease presenting as a painful red eye. It is remaining as one of the important cause of Blindness not only because of Senile cataract but even after cataract surgery due to Glaucoma caused by neglected cataractous lens. Even after advanced surgical techniques being invented in recent decades and immense efforts of National Programme of Control of Blindness, Lack of awareness among especially Rural population of India is causing them to remain with cataractous lens for a prolonged period. So necessary steps should be taken to health educate especially Rural population of India, the importance of timely surgery for better visual outcome and the dangers of poor visual result if cataract surgery is delayed.

  16. Inhibitory Role of Greatwall-Like Protein Kinase Rim15p in Alcoholic Fermentation via Upregulating the UDP-Glucose Synthesis Pathway in Saccharomyces cerevisiae.

    Watanabe, Daisuke; Zhou, Yan; Hirata, Aiko; Sugimoto, Yukiko; Takagi, Kenichi; Akao, Takeshi; Ohya, Yoshikazu; Takagi, Hiroshi; Shimoi, Hitoshi

    2015-01-01

    The high fermentation rate of Saccharomyces cerevisiae sake yeast strains is attributable to a loss-of-function mutation in the RIM15 gene, which encodes a Greatwall-family protein kinase that is conserved among eukaryotes. In the present study, we performed intracellular metabolic profiling analysis and revealed that deletion of the RIM15 gene in a laboratory strain impaired glucose-anabolic pathways through the synthesis of UDP-glucose (UDPG). Although Rim15p is required for the synthesis of trehalose and glycogen from UDPG upon entry of cells into the quiescent state, we found that Rim15p is also essential for the accumulation of cell wall ?-glucans, which are also anabolic products of UDPG. Furthermore, the impairment of UDPG or 1,3-?-glucan synthesis contributed to an increase in the fermentation rate. Transcriptional induction of PGM2 (phosphoglucomutase) and UGP1 (UDPG pyrophosphorylase) was impaired in Rim15p-deficient cells in the early stage of fermentation. These findings demonstrate that the decreased anabolism of glucose into UDPG and 1,3-?-glucan triggered by a defect in the Rim15p-mediated upregulation of PGM2 and UGP1 redirects the glucose flux into glycolysis. Consistent with this, sake yeast strains with defective Rim15p exhibited impaired expression of PGM2 and UGP1 and decreased levels of ?-glucans, trehalose, and glycogen during sake fermentation. We also identified a sake yeast-specific mutation in the glycogen synthesis-associated glycogenin gene GLG2, supporting the conclusion that the glucose-anabolic pathway is impaired in sake yeast. These findings demonstrate that downregulation of the UDPG synthesis pathway is a key mechanism accelerating alcoholic fermentation in industrially utilized S. cerevisiae sake strains. PMID:26497456

  17. Usefulness of {sup 18}F fluoride PET/CT in breast cancer patients with osteosclerotic bone metastases

    Yoon, Seok Ho; Kim, Ku Sang; Kang, Seok Yun; Song, Hee Sung; Jo, Kyung Sook; Lee, Su Jin; Yoon, Joon Kee; An, Young Sil [Ajou Univ., Suwon (Korea, Republic of); Choi, Bong Hoi [Gyeongsang National Univ. Hospital, Jinju (Korea, Republic of)

    2012-03-15

    Bone metastasis is an important factor for the treatment and prognosis of breast cancer patients. Whole body bone scintigraphy (WBBS) can evaluate skeletal metastases, and {sup 18}F FDG PET/CT seems to exhibit high specificity and accuracy in detecting bone metastases. However, there is a limitation of {sup 18}F FDG PET in assessing sclerotic bone metastases because some lesions may be undetectable. Recent studies showed that {sup 18}F fluoride PET/CT is more sensitive than WBBS in detecting bone metastases. This study aims to evaluate the usefulness of {sup 18}F fluoride PET/CT by comparing it with WBBS and {sup 18}F FDG PET/CT in breast cancer patients with osteosclerotic skeletal metastases. Nine breast cancer patients with suspected bone metastases (9 females; mean age {+-} SD, 55.6{+-}10.0 years) underwent {sup 99m}Tc MDP WBBS, {sup 18}F FDG PET/CT and {sup 18}F fluoride PET/CT. Lesion based analysis of five regions of the skeletons(skull, vertebral column, thoracic cage, pelvic bones and long bones of extremities) and patient based analysis were performed. {sup 18}F fluoride PET/CT, {sup 18}F FDG PET/CT and WBBS detected 49, 20 and 25 true metastases, respectively. Sensitivity, specificity, positive predictive value and negative predictive value of {sup 18}F fluoride PET/CT were 94.2%, 46.3%, 57.7% and 91.2%, respectively. Most true metastatic lesions of {sup 18}F fluoride PET/CT had osteosclerotic change (45/49, 91.8%), and only four lesions showed osteolytic change. Most lesions on {sup 18}F FDG PET/CT also demonstrated osteosclerotic change (17/20, 85.0%) with three osteolytic lesions. All true metastatic lesions detected on WBBS and {sup 18}F FDG PET/CT were identified on {sup 18}F fluoride PET/CT. {sup 18}F FDG PET/CT in detecting osteosclerotic metastatic lesions. {sup 18}F fluoride PET/CT might be useful in evaluating osteosclerotic metastases in breast cancer patients.

  18. Bone cysts and cystic lesions of bone

    Cystic and cyst-like lesions of bone are very common. They can be of primary origin or secondarily caused by several diseases. For exact diagnosis or at least narrow differential diagnosis the assessment of radiological findings is important. However, patient data, clinical symptoms, laboratory parameters, and site of the lesion have to be included for a reasonable final diagnosis or differential diagnosis. (orig.)

  19. What Is a Bone Marrow Transplant?

    ... this page Print this page What is a bone marrow transplant? A bone marrow or cord blood transplant is ... with healthy bone marrow. Tweet What is a bone marrow transplant How a bone marrow transplant works Transplant process ...

  20. The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences.

    Clemson, Christine Moulton; Hall, Lisa L; Byron, Meg; McNeil, John; Lawrence, Jeanne Bentley

    2006-05-16

    We investigated whether genes escape X chromosome inactivation by positioning outside of the territory defined by XIST RNA. Results reveal an unanticipated higher order organization of genes and noncoding sequences. All 15 X-linked genes, regardless of activity, position on the border of the XIST RNA territory, which resides outside of the DAPI-dense Barr body. Although more strictly delineated on the inactive X chromosome (Xi), all genes localized predominantly to the outer rim of the Xi and active X chromosome. This outer rim is decorated only by X chromosome DNA paints and is excluded from both the XIST RNA and dense DAPI staining. The only DNA found well within the Barr body and XIST RNA territory was centromeric and Cot-1 DNA; hence, the core of the X chromosome essentially excludes genes and is composed primarily of noncoding repeat-rich DNA. Moreover, we show that this core of repetitive sequences is expressed throughout the nucleus yet is silenced throughout Xi, providing direct evidence for chromosome-wide regulation of "junk" DNA transcription. Collective results suggest that the Barr body, long presumed to be the physical manifestation of silenced genes, is in fact composed of a core of silenced noncoding DNA. Instead of acting at a local gene level, XIST RNA appears to interact with and silence core architectural elements to effectively condense and shut down the Xi. PMID:16682630

  1. Mesoscale Raised Rim Depressions (MRRDs) on Earth: A Review of the Characteristics, Processes, and Spatial Distributions of Analogs for Mars

    Burr, Devon M.; Bruno, Barbara C.; Lanagan, Peter D.; Glaze, Lori; Jaeger, Windy L.; Soare, Richard J.; Tseung, Jean-Michel Wan Bun; Skinner, James A. Jr.; Baloga, Stephen M.

    2008-01-01

    Fields of mesoscale raised rim depressions (MRRDs) of various origins are found on Earth and Mars. Examples include rootless cones, mud volcanoes, collapsed pingos, rimmed kettle holes, and basaltic ring structures. Correct identification of MRRDs on Mars is valuable because different MRRD types have different geologic and/or climatic implications and are often associated with volcanism and/or water, which may provide locales for biotic or prebiotic activity. In order to facilitate correct identification of fields of MRRDs on Mars and their implications, this work provides a review of common terrestrial MRRD types that occur in fields. In this review, MRRDs by formation mechanism, including hydrovolcanic (phreatomagmatic cones, basaltic ring structures), sedimentological (mud volcanoes), and ice-related (pingos, volatile ice-block forms) mechanisms. For each broad mechanism, we present a comparative synopsis of (i) morphology and observations, (ii) physical formation processes, and (iii) published hypothesized locations on Mars. Because the morphology for MRRDs may be ambiguous, an additional tool is provided for distinguishing fields of MRRDs by origin on Mars, namely, spatial distribution analyses for MRRDs within fields on Earth. We find that MRRDs have both distinguishing and similar characteristics, and observation that applies both to their mesoscale morphology and to their spatial distribution statistics. Thus, this review provides tools for distinguishing between various MRRDs, while highlighting the utility of the multiple working hypotheses approach.

  2. A Novel Approach for Full-Thickness Defect of the Nasal Alar Rim: Primary Closure of the Defect and Reduction of the Contralateral Normal Ala for Symmetry.

    Choe, Yun Seon; Kim, Min-Woo; Jo, Seong Jin

    2015-12-01

    In full-thickness defects of the nasal alar rim, to achieve projection and maintain airway patency, cartilage graft is frequently needed. However, cartilage graft presents a challenge in considerations such as appropriate donor site, skeletal shape and size, and healing of the donor area. To avoid these demerits, we tried primary closure of alar rim defects by also making the contralateral normal ala smaller. We treated two patients who had a full-thickness nasal alar defect after tumor excision. Cartilage graft was considered for the reconstruction. However, their alar rims were overly curved and their nostril openings were large. To utilize their nasal shape, we did primary closure of the defect rather than cartilage graft, and then downsized the contralateral nasal ala by means of wedge resection to make the alae symmetric. Both patients were satisfied with their aesthetic results, which showed a smaller nostril and nearly straight alar rims. Moreover, functionally, there was no discomfort during breathing in both patients. We propose our idea as one of the reconstruction options for nasal alar defects. It is a simple and easy-to-perform procedure, in addition to enhancing the nasal contour. This method would be useful for patients with a large nostril and an overly curved alar rim. PMID:26719646

  3. Bone strength in children: understanding basic bone biomechanics.

    Forestier-Zhang, Lydia; Bishop, Nick

    2016-02-01

    The term 'bone strength' is often used to explain why some children's bones fracture while others do not. Bone strength describes the general integrity of bone; a complex organ with multiple structural levels and an array of biomechanical properties. Key biomechanical properties of bone include stiffness, toughness, ductility and mechanical strength. When measured in bone tissue, these properties are known as the intrinsic biomechanical properties of bone, while the extrinsic biomechanical properties reflect the structural behaviour of a whole bone. The fine balance between various and often opposing intrinsic and extrinsic biomechanical properties of bone is crucial for fracture resistance. When clinically evaluating a child with a fracture, an understanding of basic bone biomechanics helps determine the likely mechanism of injury and whether underlying reduced fracture resistance exists. PMID:26269494

  4. Paget Disease of Bone.

    Al-Rashid, Mamun; Ramkumar, Dipak B; Raskin, Kevin; Schwab, Joseph; Hornicek, Francis J; Lozano-Calderón, Santiago A

    2015-10-01

    The current understanding of Paget disease of bone (PDB) has vastly changed since Paget described the first case in 1877. Medical management of this condition remains the mainstay of treatment. Surgical intervention is usually only used in fractures through pagetic bone, need for realignment to correct deformity in major long bones, prophylactic treatment of impending fractures, joint arthroplasty in severe arthritis, or spinal decompression in cases of bony compression of neural elements. Advances in surgical technique have allowed early return to function and mobilization. Despite medical and surgical intervention, a small subset of patients with PDB develops Paget sarcoma. PMID:26410646

  5. Periodontal bone lesions

    In the course of life the periodontum is subject to changes which may be physiological or pathological. Intraoral radiographs give insight into the hard structures of the dentomaxillar region and provides information on lesions in the bone of the periodontum in that they show radiopacities and radiolucencies caused by such lesions. In this thesis the relation is investigated between the true shape and dimensions of periodontal bone lesions and their radiographic images. A method is developed and tested of making standardized and reproducible radiographs suitable for longitudinal studies of periodontal lesions. Also the possibility is demonstrated of an objective and reproducible interpretation of radiographic characteristics of periodontal bone lesions. (Auth.)

  6. Hidden bone erosions

    F. Salaffi

    2011-09-01

    Full Text Available The aim of this pictorial essay was to demonstrate the diagnostic efficacy of high-resolution sonography in detecting bone erosions in a patient with rheumatoid arthritis. Standard X-Ray of the feet did not reveal clearly evident erosions. Ultrasonography was able to detect the presence of bone erosions of the metatarsal heads of both the first toes and of the V toe of the left foot. Because the appearance of bone erosions on radiographs of a patient with a recent onset arthritis indicates a poor prognosis, the possibility of demonstrating small hidden erosions at the level of the early targets of the disease is of relevant practical value.

  7. Bone scintigraphy for horses

    Scintigraphy (bone scan) is being used approximately since 1980 in the horse under general anaesthesia. With the construction of custom-made overhead gantries for gamma-cameras scintigraphy found widespread entry in big equine referral hospitals for bone-scanning of the standing horse. Indications for the use of a bone scan in the horse are inflammatory alterations in the locomotor apparatus. It is primarily used for diagnosis of lameness of unknown origin, suspect of stress fracture or hairline fracture and for horses with bad riding comfort with suspected painful lesions in the spine. (orig.)

  8. BONE MORPHOGENETIC PROTEINS: A NEW VISTA IN BONE REGENERATION

    Muktevi

    2014-01-01

    Treatment of delayed union, malunion, and nonunion is a challenge to the orthopedic surgeons Apart from restoration of alignment and stable fixation, in many cases adjunctive measures such as bone-grafting or use of bone-graft substitutes are of paramount importance. Autologous bone remains the “gold standard” for stimulating bone repair and regeneration, but its availability may be limited and the procedure to harvest the material is associated with complications. Bone-graft ...

  9. Interparietal bones in Nigerian skulls.

    S K Saxena; Chowdhary, D S; Jain, S P

    1986-01-01

    The study was conducted on 40 adult Nigerian skulls which were examined for the presence of interparietal and pre-interparietal bones. Only one interparietal bone was found (2.5% of the present series) while a single pre-interparietal bone was found in four skulls (10%) and multiple pre-interparietal bones in one skull (2.5%).

  10. Bone X-Ray (Radiography)

    Full Text Available ... Professions Site Index A-Z X-ray (Radiography) - Bone What is Bone X-ray (Radiography)? What are ... limitations of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is ...

  11. Bone X-Ray (Radiography)

    Full Text Available ... News Physician Resources Professions Site Index A-Z X-ray (Radiography) - Bone What is Bone X-ray (Radiography)? What ... of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive ...

  12. Can bone scintigraphy predict the final outcome of pasteurized autografts?

    As pasteurization is becoming more widely used in limb salvage reconstruction, more study is required to understand about host-graft junction healing, graft revascularization and incorporation, and the incidence and type of complications among pasteurized autografts. This was mainly achieved by follow-up radiography. We aimed to clarify whether Tc99m bone scanning can be considered a reliable method in determining these three parameters. Twenty-seven osteosarcoma patients with pasteurized autograft reconstructions were retrospectively reviewed using available scintigraphic and radiographic follow-up every 6 months postoperatively for 36 months. Follow-up of the unhealed cases was continued for the maximum follow-up period available for each case beyond the original study period, ranging from 1 to 15 months. Tc99m uptake was classified as cold, faint, moderate and high uptake. Junction healing was classified as none, partial and complete healing. Seventy percent of junctions united with a mean of 22 months. Ninety to 100% of junctions showed increased uptake (high or moderate) at one time of the study regardless of final outcome. 85% of the pasteurized grafts showed the characteristic ''tramline appearance''. Four grafts (15%) were complicated: pseudoarthrosis and implant failure (1), fractured plate (1), intramedullary nail (IMN) fracture (1), and prosthesis stem loosening in the host bone (1), with underlying unhealed junctions in all cases. Bone scanning can determine the stages of the graft's rim revascularization and incorporation; however, it cannot detect or predict junction healing or occurrence of complications. Supplementary treatment of unhealed junctions showing either decreased junctional uptake or graft quiescence may be warranted. Otherwise, detection of distant metastasis and early local recurrence remains the main application of Tc99m scanning in the management of bone sarcomas. (orig.)

  13. Can bone scintigraphy predict the final outcome of pasteurized autografts?

    Eid, Ahmed Shawky [Ain Shams University, Department of Orthopedic Surgery, Cairo (Egypt); Jeon, Dae-Geun; Cho, Wan Hyeong [Korea Cancer Center Hospital, Department of Orthopedic Surgery, Seoul (Korea)

    2010-10-15

    As pasteurization is becoming more widely used in limb salvage reconstruction, more study is required to understand about host-graft junction healing, graft revascularization and incorporation, and the incidence and type of complications among pasteurized autografts. This was mainly achieved by follow-up radiography. We aimed to clarify whether Tc99m bone scanning can be considered a reliable method in determining these three parameters. Twenty-seven osteosarcoma patients with pasteurized autograft reconstructions were retrospectively reviewed using available scintigraphic and radiographic follow-up every 6 months postoperatively for 36 months. Follow-up of the unhealed cases was continued for the maximum follow-up period available for each case beyond the original study period, ranging from 1 to 15 months. Tc99m uptake was classified as cold, faint, moderate and high uptake. Junction healing was classified as none, partial and complete healing. Seventy percent of junctions united with a mean of 22 months. Ninety to 100% of junctions showed increased uptake (high or moderate) at one time of the study regardless of final outcome. 85% of the pasteurized grafts showed the characteristic ''tramline appearance''. Four grafts (15%) were complicated: pseudoarthrosis and implant failure (1), fractured plate (1), intramedullary nail (IMN) fracture (1), and prosthesis stem loosening in the host bone (1), with underlying unhealed junctions in all cases. Bone scanning can determine the stages of the graft's rim revascularization and incorporation; however, it cannot detect or predict junction healing or occurrence of complications. Supplementary treatment of unhealed junctions showing either decreased junctional uptake or graft quiescence may be warranted. Otherwise, detection of distant metastasis and early local recurrence remains the main application of Tc99m scanning in the management of bone sarcomas. (orig.)

  14. Osteopetrosis (marble bone disease

    Alexey Nikolayevich Kalyagin

    2014-03-01

    Full Text Available We report the data of the history of describing osteopetrosis (marble bone disease, its clinical features, diagnosis, and possible therapy approaches. Our own clinical case is presented.

  15. What Is Bone Cancer?

    ... tumor, are sensitive to treatment with radiation and chemotherapy. Ewing tumor: Ewing tumor is the third most common primary bone cancer, and the second most common in children, adolescents, and young adults. This cancer (also called Ewing sarcoma ) is ...

  16. The petrous bone

    Jørkov, Marie Louise Schjellerup; Heinemeier, Jan; Lynnerup, Niels

    2009-01-01

    Intraskeletal variation in the composition of carbon (delta(13)C) and nitrogen (delta(15)N) stable isotopes measured in collagen is tested from various human bones and dentine. Samples were taken from the femur, rib, and petrous part of the temporal bone from well-preserved skeletons of both adults...... (n = 34) and subadults (n = 24). Additional samples of dentine from the root of 1st molars were taken from 16 individuals. The skeletal material is from a medieval cemetery (AD 1200-1573) in Holbaek, Denmark. Our results indicate that the petrous bone has an isotopic signal that differs significantly...... from that of femur and rib within the single skeleton (P < 0.001 and P < 0.001, respectively), with only minor variation seen between femur and rib. On the other hand, there was no significant difference between the petrous bone and the 1st molar. The intraskeletal variation may reflect differences in...

  17. Archival bone marrow samples

    Lund, Bendik; Najmi, Laeya A; Wesolowska-Andersen, Agata; Landsem, Veslemøy M; Rasmussen, Kirsten Kørup; Borst, Louise; Gupta, Ramneek; Schmiegelow, Kjeld; Klungland, Helge

    2015-01-01

    AB Archival samples represent a significant potential for genetic studies, particularly in severe diseases with risk of lethal outcome, such as in cancer. In this pilot study, we aimed to evaluate the usability of archival bone marrow smears and biopsies for DNA extraction and purification, whole...... genome amplification (WGA), multiple marker analysis including 10 short tandem repeats, and finally a comprehensive genotyping of 33,683 single nucleotide polymorphisms (SNPs) with multiplexed targeted next-generation sequencing. A total of 73 samples from 21 bone marrow smears and 13 bone marrow...... compared with samples stored for 4 to 10 years. Acceptable call rates for SNPs were detected for 7 of 42 archival samples. In conclusion, archival bone marrow samples are suitable for DNA extraction and multiple marker analysis, but WGA was less successful, especially when longer fragments were analyzed...

  18. Sodium and bone health

    Teucher, B.; Dainty, J. R.; Spinks, C. A.; Majsak-Newman, G.; Berry, D. J.; Hoogeweff, J. A.; Foxall, R. J.; Jakobsen, Jette; Cashman, K. D.; Flynn, A.; Fairweather-Tait, S. J.

    2008-01-01

    High salt intake is a well-recognized risk factor for osteoporosis because it induces calciuria, but the effects of salt on calcium metabolism and the potential impact on bone health in postmenopausal women have not been fully characterized. This study investigated adaptive mechanisms in response.......9 Versus 11.2 g) diets, reflecting lower and upper intakes in post men opausal women consuming a Western-style diet, were provided. Stable isotope labeling techniques were used to measure calcium absorption and excretion, compartmental modeling was undertaken to estimate bone calcium balance, and...... biomarkers of bone formation and resorption were measured in blood and urine. Moderately high salt intake (11.2 g/d) elicited a significant increase in urinary calcium excretion (p = 0.0008) and significantly affected bone calcium balance with the high calcium diet 0.024). Efficiency of calcium absorption...

  19. Metastatic Bone Disease

    ... frequently seen in spread of prostate, bladder, and stomach cancer. Breast cancer o en behaves in a mixed ... treatment options to be most effective in maintaining quality of life. A technetium bone scan demon- strates ...

  20. Chondromyxoid fibroma of the acromium with soft tissue extension

    Macdonald, D. [Departments of Anatomic and Clinical Pathology, Sunnybrook and Women' s College Health Sciences Centre, Orthopedic and Arthritic Institute, Toronto, Ontario (Canada); University of Toronto, Toronto, Ontario (Canada); Fornasier, V. [Department of Anatomical Pathology and Cytology, St. Michael' s Hospital, Wellesley-Central Site, Toronto, Ontario (Canada); Holtby, R. [Department of Surgery, Sunnybrook and Women' s College Health Sciences Centre, Orthopedic and Arthritic Institute, Toronto, Ontario (Canada)

    2000-03-30

    Chondromyxoid fibroma is an unusual, benign tumor of cartilaginous origin and represents less than 1% of all primary bone tumors. It usually involves the long bones around the knee joint or the flat bones of the pelvis or ribs. Soft tissue extension is also thought to be rare in these lesions. They are usually eccentrically located in the metaphyses of the long bones and centrally in the flat bones. The radiographic appearances are characteristically those of a single, lytic lesion with lobulated margins, septations, cortical expansion and a sclerotic rim. Histologically, they display a lobulated pattern with spindle-shaped cells lying within a myxoid matrix with areas of hyaline cartilage. The differential diagnosis includes giant cell tumor, chondroblastoma or enchondroma as well as chondrosarcoma. The rarity of these lesions may render the diagnosis difficult to make, especially when the lesion involves an unusual site such as the acromium. (orig.)