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Sample records for sclerotic bone rim

  1. Fixation of hydroxyapatite-coated revision implants is improved by the surgical technique of cracking the sclerotic bone rim

    DEFF Research Database (Denmark)

    Elmengaard, Brian; Bechtold, Joan E; Chen, X; Søballe, Kjeld

    2009-01-01

    Revision joint replacement has poorer outcomes that have been associated with poorer mechanical fixation. We investigate a new bone-sparing surgical technique that locally cracks the sclerotic bone rim formed during aseptic loosening. We inserted 16 hydroxyapatite-coated implants bilaterally in the...... perform a systematic local perforation of the sclerotic bone rim of the revision cavity. After 4 weeks, the hydroxyapatite-coated implants were evaluated for mechanical fixation by a push-out test and for tissue distribution by histomorphometry. The cracking revision procedure resulted in significantly...... improved mechanical fixation, significantly more bone ongrowth and bone volume in the gap, and reduced fibrous tissue compared to the control revision procedure. The study demonstrates that the sclerotic bone rim prevents bone ingrowth and promotes fixation by fibrous tissue. The effect of the cracking...

  2. Cystinosis with sclerotic bone lesions.

    Science.gov (United States)

    Sirrs, S; Munk, P; Mallinson, P I; Ouellette, H; Horvath, G; Cooper, S; Da Roza, G; Rosenbaum, D; O'Riley, M; Nussbaumer, G; Hoang, L N; Lee, C H

    2014-01-01

    A 26-year-old male with nephropathic cystinosis treated with cysteamine and renal transplantation presented for evaluation of multiple sclerotic bone lesions, which were an incidental finding on chest computerized tomography. These lesions were in a pattern consistent with osteoblastic metastases. He did not have a history of clinically significant hyperparathyroidism or cytopenias either preceding or following his transplant. Bone and tumor markers (including alkaline phosphatase and calcium) were all normal. A percutaneous bone biopsy of the lesions showed changes compatible with cystine deposition. Our case demonstrates that sclerotic bone lesions can be a feature of cystinosis in patients with normal parathyroid function and that significant bone marrow infiltration with cystine can be present even in the absence of cytopenias. PMID:24097416

  3. Quantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study.

    OpenAIRE

    Messiou, C; Collins, DJ; Morgan, VA; Robson, MD; deBono, JS; Bydder, GM; deSouza, NM

    2010-01-01

    INTRODUCTION: Ultra Short TE MRI allows signal to be detected from tissues with a very short T2.The aims of this study were to optimize a 2D UTE MRI sequence for imaging and quantification of sclerotic bone metastases, establish T2* values of sclerotic components and investigate the feasibility of using the method to assess changes in T2* of sclerotic metastases and their relation to attenuation values in patients on treatment. METHODS: Twenty-two subjects were recruited in 3 cohorts. Cohort ...

  4. An Inflammatory Dentigerous Cyst Shows Rim Uptake on Bone Scan: A Case Report

    International Nuclear Information System (INIS)

    Dentigerous cysts are developmental odontogenic jaw cysts, commonly manifesting in the 2nd and 3rd decades of life. This article presents an extremely rare case of dentigerous cyst showing increased uptake in the peripheral rim on bone scan. Herein, we discuss the clinical, radiographic, and histologic features of dentigerous cysts as well as the pathological mechanism underlying their activities on the bone scan. Bone scan was a sensitive tool for detecting the biologic activity of dentigerous cyst in our case

  5. The effects of hydroxyapatite coating and bone allograft on fixation of loaded experimental primary and revision implants

    DEFF Research Database (Denmark)

    Søballe, Kjeld; Mouzin, Olivier R G; Kidder, Louis A; Overgaard, Søren; Bechtold, Joan E

    2003-01-01

    the presence of particulate polyethylene. During this procedure, a sclerotic endosteal bone rim forms, and a dense fibrous membrane is engendered, having macrophages with ingested polyethylene and high levels of inflammatory cytokines. At the time of revision after 8 weeks, the cavity is revised with...

  6. The effects of hydroxyapatite coating and bone allograft on fixation of loaded experimental primary and revision implants

    DEFF Research Database (Denmark)

    Søballe, Kjeld; Mouzin, Olivier R G; Kidder, Louis A; Overgaard, Søren; Bechtold, Joan E

    2003-01-01

    We used our established experimental model of revision joint replacement to examine the roles of hydroxyapatite coating and bone graft in improving the fixation of revision implants. The revision protocol uses the Søballe micromotion device in a preliminary 8-week period of implant instability for the presence of particulate polyethylene. During this procedure, a sclerotic endosteal bone rim forms, and a dense fibrous membrane is engendered, having macrophages with ingested polyethylene and high...

  7. Imaging spectrum in sclerotic myelomas: an experience of three cases

    Energy Technology Data Exchange (ETDEWEB)

    Grover, S.B.; Dhar, A. [Dept. of Radiology, Safdarjang Hospital, New Delhi (India)

    2000-11-01

    The classic radiographic presentation of multiple myeloma is lytic skeletal lesions. Primary sclerotic manifestations are rare and occur only in 3 % of cases. The imaging spectrum in three cases of multiple myeloma with primary osteosclerosis is described. The first patient had spiculated sclerosis of the orbit, which is an uncommon site for myeloma. The second patient with POEMS syndrome had multiple, scattered, skeletal lesions with sclerotic margins. The third patient presented with a chest wall mass and had an expansile thick spiculated sclerosis in the rib. The wide imaging spectrum possible in sclerotic myelomas and their relevant differential diagnosis is emphasized. (orig.)

  8. The sclerotic pedicle - how many causes are there?

    International Nuclear Information System (INIS)

    The sclerotic pedicle is a commonly encountered roentgen sign that may be associated with numerous conditions, both benign and malignant. The following paper discusses the common as well as the unusual causes of this interesting phenomenon and demonstrates the radiographic presentations of the various etiologies. (orig.)

  9. Indian Ocean Rim Cooperation

    DEFF Research Database (Denmark)

    Wippel, Steffen

    Since the mid-1990s, the Indian Ocean has been experiencing increasing economic cooperation among its rim states. Middle Eastern countries, too, participate in the work of the Indian Ocean Rim Association, which received new impetus in the course of the current decade. Notably Oman is a very acti...... member of this organisation and has established manifold economic links with countries of the region....

  10. Alar Rim Deformities.

    Science.gov (United States)

    Totonchi, Ali; Guyuron, Bahman

    2016-01-01

    The alar rim plays an important role in nasal harmony. Alar rim flaws are common following the initial rhinoplasty. Classification of the deformities helps with diagnosis and successful surgical correction. Diagnosis of the deformity requires careful observation of the computerized or life-sized photographs. Techniques for treatment of these deformities can easily be learned with attention to detail. PMID:26616701

  11. Transplante renal sem imunossupressão de manutenção. Pares monozigóticos e receptores de rim e medula óssea do mesmo doador / Renal transplantation without maintenance immunosuppression. Identical twins and kidney transplantation following a successful bone marrow graft

    Scientific Electronic Library Online (English)

    Riad Abdel, Hadi; Gustavo Gomes, Thomé; Adriana Reginato, Ribeiro; Roberto Ceratti, Manfro.

    2015-06-01

    Full Text Available Resumo Pacientes que receberam transplantes renais sem imunossupressão de manutenção têm sido esporadicamente relatados. Os casos incluem relatos de pacientes não aderentes que suspenderam a medicação imunossupressora, transplantes entre gêmeos monozigóticos, transplante renal após um bem sucedido t [...] ransplante de medula óssea do mesmo doador e transplante simultâneo de medula óssea e rim para tratamento de pacientes com mieloma múltiplo com insuficiência renal associada. Existem, atualmente, ensaios clínicos em andamento com o propósito de induzir tolerância imunológica específica ao doador utilizando a infusão de células hematopoiéticas do mesmo doador do enxerto renal. A seguir, descrevemos dois casos de transplante renal sem imunossupressão como exemplos de situações descritas acima. Abstract in english Abstract Renal transplantation without maintenance immunosuppression has been sporadically reported in the literature. The cases include non-adherent patients who discontinued their immunosuppressive medications, transplantation between identical twins, kidney transplantation after a successful bone [...] marrow graft from the same donor and simultaneous bone marrow and kidney transplantation for the treatment of multiple myeloma with associated renal failure. There are also ongoing clinical trials designed to induce donor specific transplant tolerance with infusion of hematopoietic cells from the same kidney donor. Here we describe two cases of renal transplantation without immunosuppression as examples of situations described above.

  12. Micromorphological and hardness analyses of human and bovine sclerotic dentin: a comparative study

    Directory of Open Access Journals (Sweden)

    Gisela Muassab Castanho

    2011-06-01

    Full Text Available The purpose of this study was to test the hypothesis that both human and bovine sclerotic dentin have similar hardness properties, in addition to similar micromorphological characteristics. Sixteen teeth (8 human and 8 bovine exhibiting exposed dentin in the incisal edge and showing characteristics typical of sclerosis were used. Vickers surface microhardness testing was conducted. Three areas of the dentin surface of each specimen were selected. All teeth were processed for scanning electron microscopy in order to estimate the amount (in percentage of solid dentin on the sclerotic dentin surface. The data were compared by Student's t test (? = 0.05. The micromorphological and microhardness data were compared by Pearson's linear correlation test (? = 0.05. The mean percentages of solid dentin of human and bovine sclerotic dentin were similar (human 90.71 ± 0.83 and bovine 89.08 ± 0.81, p = 0.18. The mean microhardness value (VHN of human sclerotic dentin was significantly higher than that of bovine sclerotic dentin (human 45.26 ± 2.92 and bovine 29.93 ± 3.83, p = 0.006. No correlation was found between the microhardness values and the amount of solid dentin in the sclerotic dentin, irrespective of the species considered (human R² = 0.0240, p = 0.714; bovine R² = 0.0017, p = 0.923; and combined R² = 0.038, p = 0.46. We concluded that although both bovine and human sclerotic dentin present a similar amount of solid tissue, human sclerotic dentin presents higher microhardness than bovine sclerotic dentin.

  13. Rim Sign in Acute Cholecystitis

    International Nuclear Information System (INIS)

    The 'rim sign' is a rim of increased hepatic activity adjacent to the gall bladder fossa and known as an useful indicator of acute cholecystitis. Also, many reports suggested that if rim sign is positive there is an increased risk for complications such as perforation and gangrene. To evaluate the usefulness of this rim sign, we reviewed 32 cases that were pathologically confirmed. The incidence of rim sign was 47% similar to other reports but with our results, the rim sign was not specific to acute cholecystitis nor indicator of increased risk for complications.

  14. Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases.

    Science.gov (United States)

    Lee, Seung Yun; Cardones, Adela R; Doherty, Joshua; Nightingale, Kathryn; Palmeri, Mark

    2015-11-01

    In this study, acoustic radiation force impulse (ARFI) and shear wave elasticity imaging (SWEI) were applied to the skin to investigate the feasibility of their use in assessing sclerotic skin diseases. Our motivation was to develop a non-invasive imaging technology with real-time feedback of sclerotic skin disease diagnosis. This paper shows representative results from an ongoing study, recruiting patients with and without sclerosis. The stiffness of the imaged site was evaluated using two metrics: mean ARFI displacement magnitude and bulk shear wave speed inside the region of interest (ROI). In a subject with localized graft versus host disease (GVHD), the mean ARFI displacement inside sclerotic skin was 61% lower (p ARFI and SWEI can successfully differentiate sclerotic lesions from normal dermis. PMID:26259888

  15. Comparison of Sporadic Sclerotic Fibroma and Solitary Fibrous Tumor in the Oral Cavity

    OpenAIRE

    Lee, Ju-Han; An, Jung-Suk; Lee, Eung Seok; Kwon, Soon-Young; Kim, Young-Sik

    2007-01-01

    Sporadic sclerotic fibroma (SF) and solitary fibrous tumor (SFT) arising in the oral cavity are very rare. In this report, we describe two cases of oral pathology, one involving SF and the other involving SFT. Both cases presented with well-circumscribed, firm nodules with similar gross findings. However, the histologic findings of the SF and SFT showed rather distinct features. The SF was composed of hyalinized sclerotic collagen bundles arranged in a whorled pattern, whereas the SFT was for...

  16. Sclerotic fibroma-like dermatofibroma: an uncommon distinctive variant of dermatofibroma

    OpenAIRE

    González-Vela, M.C.; Val-Bernal, José Fernando; de Martino, M; González-López, M.A.; García-Alberdi, E.; Hermana, S.

    2005-01-01

    Dermatofibroma (DF) is a common benign cutaneous tumor with many variants based on alterations in the morphology and composition of its diverse elements. One very infrequent type is sclerotic fibromalike DF (SF-DF). We report 7 new cases of SF-DF. In addition, their main clinicopathological and immunohistochemical features were compared with 14 unselected common DFs and with 3 sclerotic fibromas (SFs). Microscopically, the 7 cases of SF-DFs showed an un...

  17. Microscopy comparative evaluation of the SE systems adhesion to normal and sclerotic dentin.

    Science.gov (United States)

    Florescu, Anamaria; Efrem, Ion Cristian; Haidoiu, Cerasela; Hertzog, Radu; Bîcle?anu, Florentina Cornelia

    2015-01-01

    The purpose of this study was in vitro evaluation and comparison of the adhesion of self-etch (SE) adhesive systems applied on normal and sclerotic dentin. For this study, Class 5 cavities were prepared on sound teeth as well as on teeth with sclerotic dentin. They were then restored by means of the SE 2-step OptiBond XTR (Kerr) and SE 1-step Bond Force (Tokuyama Dental) adhesive systems, as well as the Estelite Sigma Quick (Tokuyama Dental) composite resin. For teeth with sclerotic dentin, the hypermineralized superficial layer was removed by means of round bur on low speed, than the adhesive systems and composite resin were applied. These teeth were prepared for microscopic study according to the protocol specific to each microscope. SEM (scanning electron microscopy) examination reveals that on normal and sclerotic dentin, OptiBond XTR and Bond Force form hybrid layers with about the same thickness, greater in normal dentin, but only OptiBond XTR pervades into the dentinal tubules, both in normal and sclerotic dentin. However, TEM (transmission electron microscopy) examination of Bond Force reveals that it penetrates into the dentinal tubules as well, but only in the case of normal dentin. The thickness of the hybrid layers resulting from the application of the SE adhesive systems to sound dentin is different from the thickness of the hybrid layers obtained when the same adhesive systems have been applied to sclerotic dentin. PMID:26662138

  18. RIMS: Resource Information Management System

    Science.gov (United States)

    Symes, J.

    1983-01-01

    An overview is given of the capabilities and functions of the resource management system (RIMS). It is a simple interactive DMS tool which allows users to build, modify, and maintain data management applications. The RIMS minimizes programmer support required to develop/maintain small data base applications. The RIMS also assists in bringing the United Information Services (UIS) budget system work inhouse. Information is also given on the relationship between the RIMS and the user community.

  19. AVALIAÇÃO HISTOLÓGICA DE FÍGADO, RIM, TIREÓIDE, PARATIREÓIDE E OSSO DE SUÍNOS EM TERMINAÇÃO SUBMETIDOS A DIFERENTES DIETAS HISTOLOGICS AVALUATIONS OF LIVER, KIDNEY, THYROID, PARATHYROID AND METACARPIAN BONE OF FINISHING PIGS WITH DIFFERENT DIETS

    Directory of Open Access Journals (Sweden)

    Jurij Sobestiansky

    2008-12-01

    Full Text Available O objetivo do estudo foi avaliar histologicamente fígado, rim, tireóide, paratireóide e osso metacarpo de suínos submetidos a restrições de microminerais, vitaminas e fósforo, e suplementados com a enzima fitase em dois períodos de restrição. Empregaram-se 48 fêmeas suínas com idade inicial de 105 dias (66,15 ± 0,14kg, recebendo dietas experimentais à base de milho e farelos de soja e trigo. Os animais foram agrupados aleatoriamente em seis tratamentos: dieta completa (T1; dieta completa sem suplemento micromineral-vitamínico (T2; dieta sem suplemento micromineral-vitamínico e com fitase (T3; dieta sem suplemento micromineral-vitamínico, sem 1/3 de fósforo inorgânico e com fitase (T4; dieta sem suplemento micromineral-vitamínico, sem 2/3 de fósforo inorgânico e com fitase (T5; dieta sem suplemento micromineral-vitamínico, sem fósforo inorgânico e com fitase (T6. Desenvolveu-se o experimento em duas etapas, sendo a primeira composta por 24 animais, restrição de 35 dias e abate aos 150 dias (106,65 kg, e a segunda, composta por 24 animais, restrição de 60 dias e abate aos 175 dias (123,87 kg. No momento do abate, colheram-se fragmentos de fígado, rim, tireóide, paratireóide e osso metacarpiano de cada animal dos diversos tratamentos. Todos os fragmentos foram fixados em solução de formol tamponado a 10%, processados, incluídos em parafina e corados por hematoxilina e eosina (HE. Empregou-se a coloração especial de tricrômico de Mallory apenas nas amostras ósseas. Ao exame histológico dos rins foram constatados 37 animais com nefrite intersticial (77%. À histologia hepática, observou-se discreto infiltrado inflamatório mononuclear de distribuição predominantemente focal em quinze animais (31,25%. Os tratamentos preconizados não provocaram alterações histológicas nas glândulas paratireóide e tireóide. À microscopia dos ossos metacarpianos, observou-se discreta osteocondrose em animais dos diferentes tratamentos e fases de restrição. Entretanto, durante o período experimental não se registraram quaisquer alterações clínicas relacionadas a doenças metabólicas ósseas ou a osteocondrose. Ainda, de acordo com os resultados, concluiu-se que a fitase foi eficiente em disponibilizar o fósforo fítico da dieta, uma vez que não se observaram lesões ósseas macro e microscópicas características de deficiência de fósforo.

    PALAVRAS-CHAVES: Alterações histológicas, fitase, restrição de fósforo, vitaminas, microminerais. The present experiment aimed to evaluate histological changes in hepatic, renal, thyroid, parathyroid and metacarpian bone tissues of pigs submitted to diets without micro minerals and vitamins, reduced inorganic phosphorus levels and phytase addition in two restriction times. Forty eight 105-days old (66.15±0.14 kg female pigs received experimental diets with corn, soybean and wheat meal. The animals were randomly distributed in six groups: standard diets (T1; composed of corn, soybean meal and wheat meal; standard ration without micro mineral and vitamin supplement (T2; T2 ration with phytase (T3; T2 ration reducing 1/3 of inorganic phosphorus with phytase (T4; T2 ration reduced 2/3 of inorganic phosphorus with phytase (T5; and T2 ration with complete reduction of inorganic phosphorus with phytase (T6. The experiment was carried out in two phases: Phase 1. 24 animals, 35 days of restriction and slaughter at 150 days of age (106.65 kg, and Phase 2, 24 animals, 60 days of restriction and slaughter at 175 days of age (123.87 kg. At slaughter, samples of liver, kidney, thyroid, parathyroid and metacarpian bone were collected from all animals. The samples were fixed in 10% buffered formaldehyde and stained by hematoxilin and eosin (HE. The Mallory’s trichrome stain was used in bone sections. Kidney histopathological evaluation showed interstitial nephritis in 37 animals (77%. Mononuclear inflammatory infiltrated was observed focally on liver of 15 animals (31.25%. Treatments didn’t promote histopathologi

  20. Histologia e ultraestrutura do rim e rim cefálico do pacu

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    Gerlane M. Costa

    2012-05-01

    Full Text Available O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de cada órgão com o uso de microscopia de luz e microscopia eletrônica de transmissão. O resultado da análise macroscópica mostrou que a localização do rim e rim cefálico são as mesmas encontradas na maioria dos teleósteos. O rim apresentou uma forma em "H", onde a região média se expandia sobre a bexiga natatória. O rim cefálico se apresentou como uma dilatação na região cranial do rim, mostrando-se bem visível. Na microscopia eletrônica de transmissão também foram observadas similaridades ultraestruturais com outros teleósteos. Observando nossos resultados concluímos que histologicamente e ultraestruturalmente, os órgãos linfóides rim e rim cefálico de Piaractus mesopotamicus são similares aos de outros teleósteos.

  1. CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS

    Directory of Open Access Journals (Sweden)

    Taeko Nakamura-Wakatsuki

    2013-10-01

    Full Text Available Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fingers have not been reported to date. Mucin deposition in the sclerotic skin may be a predisposing factor in the induction of myxoid cyst on the scleroderma finger in our patient.

  2. Aft outer rim seal arrangement

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ching-Pang; Tham, Kok-Mun; Schroeder, Eric; Meeroff, Jamie; Miller, Jr., Samuel R; Marra, John J; Campbell, Christian X

    2015-04-28

    An outer rim seal arrangement (10), including: an annular rim (70) centered about a longitudinal axis (30) of a rotor disc (31), extending fore and having a fore-end (72), an outward-facing surface (74), and an inward-facing surface (76); a lower angel wing (62) extending aft from a base of a turbine blade (22) and having an aft end (64) disposed radially inward of the rim inward-facing surface to define a lower angel wing seal gap (80); an upper angel wing (66) extending aft from the turbine blade base and having an aft end (68) disposed radially outward of the rim outward-facing surface to define a upper angel wing seal gap (80, 82); and guide vanes (100) disposed on the rim inward-facing surface in the lower angel wing seal gap. Pumping fins (102) may be disposed on the upper angel wing seal aft end in the upper angel wing seal gap.

  3. Clinical observation of Ahmed glaucoma valve implantation for refractory glaucoma by directly puncturing the sclerotic tunnel

    Directory of Open Access Journals (Sweden)

    Zhi-Ke Xu

    2015-02-01

    Full Text Available AIM: To observe the clinic effects and complication of Ahmed glaucoma valve(AGVimplantation in refractory glaucoma by using the 23G syringe needle direct puncture the sclerotic tunnel.METHODS: Forty-four cases(44 eyesof refractory glaucoma underwent AGV implantation by useing the 23G syringe needle direct puncture the sclerotic tunnel. The intraocular pressure(IOP, visual acuity, and complication of post-operation were contrasted with those of pre-operation. RESULTS:The success rate was 84.1%, the mean preoperative IOP in research group was 52.1±10.1mmHg, and the last follow up mean IOP was 15.6±6.9mmHg. Compared with the preoperative visual acuity, 11 eyes increased, 27 eyes had no changes and 6 eyes decreased. The main post-operative complications included shallow anterior chamber(4 eyes, choroidal detachment(3 eyes, drainage tube shift(1 eye, hyphema(6 eyes, drainage tube blockage(1 eye, expulsive choroidal hemorrhage(1 eye, and fiber wrap of drainage tray(5 eyes.CONCLUSION: AGV implantation by direct puncture the sclerotic tunnel is feasible and easy. It avoids of making sclerotic petal and the xenogenic sclera transplanting, simplified the operation technique, prevent the leakage of around tube. The shallow anterior chamber rate is lower. It is an effective procedure for refractory glaucoma.

  4. Arthroscopic Acetabular Rim Resection in the Treatment of Femoroacetabular Impingement

    OpenAIRE

    Chow, Roxanne M.; Krych, Aaron J.; Levy, Bruce A.

    2013-01-01

    Appropriate identification and precise resection of the pincer lesion are integral parts of the arthroscopic surgical treatment of femoroacetabular impingement. Preoperative radiographic planning of the bone resection, as well as executing the plan intraoperatively using both fluoroscopic and arthroscopic cues, is critical to adequately removing the pincer lesion. We present our surgical technique of removing the impinging bone by defining the focal acetabular rim overcoverage, accessing the ...

  5. Morphology of autogenous bone graft and castor oil polyurethane in the infraorbital rim of rabbits: a comparative study Estudo morfológico comparativo do enxerto ósseo autógeno e polímero de mamona em rebordo infra-orbitário de coelhos

    OpenAIRE

    José Carlos Garcia de Mendonça; Rafael Rossi; Celso Massaschi Inouye; Diego Rodrigo Paulillo Bazan; João Carlos Castro Monteiro; Juliana Pedroso de Mendonça

    2006-01-01

    PURPOSE: Morphological study comparing castor oil polyurethane and autogenous bone graft to repair bone defect in zygomatic bone of rabbits. METHODS: Twenty-four adult, male New Zealand rabbits were randomly distributed between two groups of twelve. Bone defects of 5mm in diameter were cut through the zygomatic bone and filled with polyurethane discs in the experimental group or autogenous bone harvested from the tibia in the control group. Animals were sacrificed after 30, 60 or 90 days, and...

  6. Ewing's sarcoma of the tarsal bone

    International Nuclear Information System (INIS)

    The Ewing's sarcoma comprises approximately less than 10 percent of malignant bone tumors and 5 percent of all bone tumors, occurs in almost all bones of the body, and presents a widely divergent roentgenographic manifestations. The tarsal bones are involved only 2 percent in the Ewing's sarcoma. Two cases experienced by authors and ten cases published in literatures of Ewing's sarcoma of the tarsal bone were analyzed retrospectively. The result were as follows: 1. Of the tarsal bones, the calcaneus was 7 cases, the talus 4 cases, cuneiform 1 case. 2. Female was affected more commonly than male, the ratio being 4 to 1 in the tarsal bones. 3. About sixty percent of total cases in the tarsal bones had evidence of diffuse sclerotic pattern. All the cases of the talus had evidence of diffuse sclerotic pattern. 4. The diseases to be considered in differential diagnosis are as follows: avascular necrosis, tuberculous osteomyelitis, osteosarcoma, and pyogenic osteomyelitis. 5. The diffuse sclerosis radiographically showed a close relation with dead bone resulting from avascular necrosis due to tumor infiltration histologically. Periosteal reactive new bone and osteoid deposition on the dead bone were also correlated with diffuse sclerosis. 6. Because it is difficult to differentiate sclerotic lesions in the tarsal bones by radiographic methods alone, all such lesions should be subject to biopsy as early as possible

  7. CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS

    OpenAIRE

    Taeko Nakamura-Wakatsuki; Toshiyuki Yamamoto

    2013-01-01

    Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fin...

  8. In vitro evaluation of the microhardness of normal and sclerotic bovine dentin

    Directory of Open Access Journals (Sweden)

    Gisela Muassab CASTANHO

    2009-06-01

    Full Text Available Introduction:The literature shows different characteristics between normal and sclerotic dentin.Hardness is a property that has been very used to compare restorative materials and biological tissues.Objective: The aim of this study was to compare the hardness clinical characteristics between the normal and the sclerotic bovine dentin, through the microhardness test.Material and methods: 20 bovine teeth were divided in two groups: GI (normal and GII (with characteristics of sclerosis.The teeth were mounted in acrylic resin cylinders with exposure of dentin along the incisal edges. The specimens received finishing and polishing following by storage in distilled water at ambient temperature for 7 days.Microhardness measurements were made using a Vickers indenter microhardness tester under a load of 50 gf for 45 s.In this study 3 areas per specimen were selected and each specimen were selected and each area received 5 indentations, resulting in 15 indentations per specimen. Results: The data were statistically processed using the Student’s t-test.The level of significance was 5%. The results showed no significant differences between the mean values of the two groups (GI: 36.82±9.45; GII:32.4±12.2 (p = 0.383.Conclusion:The normal bovine dentin presented similar microhardness Vickers values to the sclerotic bovine dentin.

  9. Portable basketball rim testing device

    Science.gov (United States)

    Abbott, W. Bruce (610 Clover St., Cheney, WA 99004); Davis, Karl C. (Box 722, Richland, WA 99352)

    1993-01-01

    A portable basketball rim rebound testing device 10 is illustrated in two preferred embodiments for testing the rebound or energy absorption characteristics of a basketball rim 12 and its accompanying support to determine likely rebound or energy absorption charcteristics of the system. The apparatus 10 includes a depending frame 28 having a C-clamp 36 for releasably rigidly connecting the frame to the basketball rim 12. A glide weight 60 is mounted on a guide rod 52 permitting the weight 60 to be dropped against a calibrated spring 56 held on an abutment surface on the rod to generate for deflecting the basketball rim and then rebounding the weight upwardly. A photosensor 66 is mounted on the depending frame 28 to sense passage of reflective surfaces 75 on the weight to thereby obtain sufficient data to enable a processing means 26 to calculate the rebound velocity and relate it to an energy absorption percentage rate of the rim system 12. A readout is provided to display the energy absorption percentage.

  10. Effects of Altered Catecholamine Metabolism on Pigmentation and Physical Properties of Sclerotized Regions in the Silkworm Melanism Mutant

    OpenAIRE

    Qiao, Liang; Li, Yuanhao; Xiong, Gao; Liu, Xiaofan; He, Songzhen; Tong, Xiaoling; Wu, Songyuan; Hu, Hai; Wang, Rixin; Hu, Hongwei; Chen, Lushi; De Zhang, Li; Wu, Jie; Dai, Fangyin; LU, Cheng

    2012-01-01

    Catecholamine metabolism plays an important role in the determination of insect body color and cuticle sclerotization. To date, limited research has focused on these processes in silkworm. In the current study, we analyzed the interactions between catecholamines and melanin genes and their effects on the pigmentation patterns and physical properties of sclerotized regions in silkworm, using the melanic mutant melanism (mln) silkworm strain as a model. Injection of β-alanine into mln mutant si...

  11. Bone

    Science.gov (United States)

    Helmberger, Thomas K.; Hoffmann, Ralf-Thorsten

    The typical clinical signs in bone tumours are pain, destruction and destabilization, immobilization, neurologic deficits, and finally functional impairment. Primary malignant bone tumours are a rare entity, accounting for about 0.2% of all malignancies. Also benign primary bone tumours are in total rare and mostly asymptomatic. The most common symptomatic benign bone tumour is osteoid osteoma with an incidence of 1:2000.

  12. Trade in the Pacific Rim.

    Science.gov (United States)

    Dollar, David

    1988-01-01

    States that international trade is a prime factor linking the Pacific Rim nations. Discusses the differences in each nation's productive factors (land, labor, capital) and examines the emerging technological competition. Concludes that if U.S. firms cannot meet the challenge of foreign competition, then protectionism might limit further economic…

  13. Ossicular bone modeling in acute otitis media

    DEFF Research Database (Denmark)

    Salomonsen, Rasmus Lysholdt; Hermansson, Ann; Cayé-Thomasen, Per

    2010-01-01

    A number of middle ear diseases are associated with pathologic bone modeling, either formative or resorptive. As such, the pathogenesis of a sclerotic mastoid has been controversial for decades. Experimental studies on acute middle ear infection have shown progressive osteoneogenesis in the bone structures surrounding the middle ear cavity, and a few studies have reported acute changes of the ossicular chain. However, detailed qualitative and quantitative information on ossicular bone modeling d...

  14. Femoroacetabular impingement with chronic acetabular rim fracture - 3D computed tomography, 3D magnetic resonance imaging and arthroscopic correlation.

    Science.gov (United States)

    Chhabra, Avneesh; Nordeck, Shaun; Wadhwa, Vibhor; Madhavapeddi, Sai; Robertson, William J

    2015-07-18

    Femoroacetabular impingement is uncommonly associated with a large rim fragment of bone along the superolateral acetabulum. We report an unusual case of femoroacetabular impingement (FAI) with chronic acetabular rim fracture. Radiographic, 3D computed tomography, 3D magnetic resonance imaging and arthroscopy correlation is presented with discussion of relative advantages and disadvantages of various modalities in the context of FAI. PMID:26191497

  15. A digital image analyser for RIMS studies

    International Nuclear Information System (INIS)

    Resonance Ionisation Mass Spectrometry (RIMS) is now playing a vital role in various areas of physics and chemistry. A digital image analyser for quantitative analysis of RIMS experiments has been developed

  16. Posterior segment nucleotomy for dislocated sclerotic cataractous lens using chandelier endoilluminator and sharp tipped chopper

    Directory of Open Access Journals (Sweden)

    Brijesh Takkar

    2015-08-01

    Full Text Available AIM:To describe a new surgical technique for managing dislocated sclerotic cataractous lens.METHODS:Six patients with advanced posteriorly dislocated cataracts were operated at a tertiary care centre and analyzed retrospectively. After standard 3 port 23 G pars plana vitrectomy and perfluorocarbon liquid (PFCL injection, the dislocated white cataract was held with occlusion using phaco fragmatome and then chopped into smaller pieces with a sharp tipped chopper using 25 G chandelier endoilluminator. Each piece was emulsified individually. Following aspiration of PFCL, Fluid Air Exchange was done in all the cases and surgery completed uneventfully.RESULTS:Best corrected visual acuity (BCVA in all the patients was better than 6/12 after one month of follow up. No serious complications were noted till minimum 6mo of follow up.CONCLUSION:Four port posterior segment nucleotomy with a chandelier endoilluminator, fragmatome and a chopper appears to be a safe, easy and effective procedure for managing dislocated sclerotic cataractous nuclei. Ultrasonic energy used and adverse thermal effects of the fragmatome on the sclera may be lesser.

  17. Mixed Buchsbaum-Rim multiplicities

    CERN Document Server

    Kleiman, S L; Kleiman, Steven; Thorup, Anders

    1994-01-01

    We prove the results about mixed Buchsbaum--Rim multiplicities announced in (9.10)(ii) on p.224 of our recent paper [J.Alg.(1994)], including a general mixed multiplicity formula. In addition, we identify these multiplicities as the coefficients of the ``leading form'' of the appropriate Buchsbaum-Rim polynomial in three variables, and we prove a positivity theorem. In fact, we define the multiplicities as the degrees of certain zero-dimensional ``mixed twisted Segre'' classes, and we develop an encompassing general theory of these new rational equivalence classes in all dimensions. In parallel, we develop a theory of pure ``twisted Segre'' classes, and we recover the main results in [J.Alg.(1994)] about the pure Buchsbaum--Rim multiplicities, the polar multiplicities, and so forth. Moreover, we identify the additivity theorem [J.Alg.(1994), (6.7b)(i), p.205] as a sort of residual-intersection formula, and we show its (somewhat unexpected) connection to the mixed multiplicity formula. Also, we work in a more ...

  18. Facing rim cavities fluctuation modes

    Science.gov (United States)

    Casalino, Damiano; Ribeiro, André F. P.; Fares, Ehab

    2014-06-01

    Cavity modes taking place in the rims of two opposite wheels are investigated through Lattice-Boltzmann CFD simulations. Based on previous observations carried out by the authors during the BANC-II/LAGOON landing gear aeroacoustic study, a resonance mode can take place in the volume between the wheels of a two-wheel landing gear, involving a coupling between shear-layer vortical fluctuations and acoustic modes resulting from the combination of round cavity modes and wheel-to-wheel transversal acoustic modes. As a result, side force fluctuations and tonal noise side radiation take place. A parametric study of the cavity mode properties is carried out in the present work by varying the distance between the wheels. Moreover, the effects due to the presence of the axle are investigated by removing the axle from the two-wheel assembly. The azimuthal properties of the modes are scrutinized by filtering the unsteady flow in narrow bands around the tonal frequencies and investigating the azimuthal structure of the filtered fluctuation modes. Estimation of the tone frequencies with an ad hoc proposed analytical formula confirms the observed modal properties of the filtered unsteady flow solutions. The present study constitutes a primary step in the description of facing rim cavity modes as a possible source of landing gear tonal noise.

  19. CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts: preliminary results

    International Nuclear Information System (INIS)

    Objective: To evaluate CT-guided once-through bilateral percutaneous needle puncturing, aspiration and injection of sclerotic agents (ethanol) in treating bilateral multiple renal cysts. Methods: CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy was performed in 19 patients with bilateral multiple renal cysts. First, under CT guidance the puncture points and puncture routs were decided, then, puncturing, aspiration, rinsing and ethanol injection of the cysts were taken place by turn. The clinical results were analyzed. Results: bilateral percutaneous needle puncturing sclerotic therapy was successfully completed in all 19 cases. The whole procedure was well tolerated by all patients. The mean operative time was 23 minutes with a range of 20-35 minutes. No severe complications occurred. Conclusion: With proficient manipulation, CT-guided bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts can be smoothly carried out. The technique can reduced the number of sclerotherapy times, cut down the medical expenses and, therefore, get twofold results with half the effort. (authors)

  20. Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice

    Scientific Electronic Library Online (English)

    Yinghua, Song; Lubing, Zhu; Ming, Li.

    2013-10-01

    Full Text Available OBJECTIVE: To investigate the antifibrotic effects of crocetin in scleroderma fibroblasts and in sclerotic mice. METHODS: Skin fibroblasts that were isolated from three systemic scleroderma (SSc) patients and three healthy subjects were treated with crocetin (0.1, 1 or 10 ?M). Cell proliferation [...] was measured with an MTT assay. Alpha-smooth muscle actin was detected via an immunohistochemical method. Alpha 1 (I) procollagen (COL1A1), alpha 1 (III) procollagen (COL3A1), matrix metalloproteinase (MMP)-1 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 mRNA levels were measured using real-time PCR. SSc mice were established by the subcutaneous injection of bleomycin. Crocetin (50 mg/kg/d) was injected intraperitoneally for 14 days. Dermal thickness and lung fibrosis were assessed with Masson's trichrome staining. Plasma ET-1 was detected with an enzyme-linked immunosorbent assay (ELISA). Skin and lung ET-1 and COL1A1 mRNA levels were measured via real-time PCR. RESULTS: Crocetin inhibited the proliferation of SSc and normal fibroblasts, an effect that increased with crocetin concentration and incubation time. Crocetin decreased the expression of ?-SMA and the levels of mRNA for COL1A1, COL3A1 and matrix metalloproteinase-1, while crocetin increased TIMP-1 mRNA levels in both SSc and normal fibroblasts. Skin and lung fibrosis was induced, and the levels of ET-1 in the plasma, skin and lungs were elevated in bleomycin-injected mice. Crocetin alleviated the thickening of the dermis and lung fibrosis; decreased COL1A1 mRNA levels in the skin and lung; and simultaneously decreased ET-1 concentrations in the plasma and ET-1 mRNA levels in the skin and lungs of the bleomycin-induced sclerotic mice, especially during the early phase (weeks 1-3). CONCLUSION: Crocetin inhibits cell proliferation, differentiation and collagen production in SSc fibroblasts. Crocetin alleviates skin and lung fibrosis in a bleomycin-induced SSc mouse model, in part due to a reduction in ET-1.

  1. The detection of sclerotic changes of the coronaries and heart valves by scanning beams (ultrafast computed tomography using EVOLUTION)

    International Nuclear Information System (INIS)

    With the advent of ultrafast computed tomography the range of diagnostic procedures for the quantitative determination of pathological changes in the coronary arteries has been broadened. The calcified coronary plaques found in this study, which in some of the patients were markedly pronounced, gave no immediate clue as to what extent sclerotic changes had already occurred in the coronaries examined. Nor was it possible on the basis of this method to pinpoint the vascular sections showing calcified plaques in patients undergoing maintenance dialysis. It may, however, permit careful predictions to be made for patients at a high risk of developing coronary artery disease. Sclerotic changes of the heart values occur with above-average frequency in dialysis patients and may be assessed quantitatively by the method described. The results described show that findings revealed by scanning electron beams may provide indirect information on metabolic processes in patients suffering from chronic ailments. (orig./MG)

  2. Thermoviscous Coating and Rimming Flow

    KAUST Repository

    Leslie, G. A.

    2012-10-22

    A comprehensive description is obtained of steady thermoviscous (that is, with temperature-dependent viscosity) coating and rimming flow of a thin film of fluid on a uniformly rotating horizontal cylinder that is uniformly hotter or colder than the surrounding atmosphere. It is found that, as in the corresponding isothermal problem, there is a critical solution with a corresponding critical load (which depends, in general, on both the Biot number B and the thermoviscosity number V) above which no \\'full-film\\' solutions corresponding to a continuous film of fluid covering the entire outside or inside of the cylinder exist. The effect of thermoviscosity on both the critical solution and the full-film solution with a prescribed load is described. In particular, there are no full-film solutions with a prescribed load M for any value of B when for positive V and when M ≥ f-1/2 Mc0 for negative V, where is a monotonically decreasing function of V and M c0 ≃ 4.44272 is the critical load in the constant-viscosity case. It is also found that, for the exponential viscosity model, when the prescribed load satisfies M < 1.50315 there is a narrow region of the B-V parameter plane in which backflow occurs. © 2012 The Author. Published by Oxford University Press; all rights reserved. For Permissions, please email: journals.permissions@oup.com.

  3. Desmoplastic Fibroma, Report of a Rare Case in Infraorbital Rim

    Science.gov (United States)

    Safi, Yaser; Shamloo, Nafise; Heidar, Hossein; Valizadeh, Solmaz; Aghdasi, Mohammad Mehdi; Eslami Manouchehri, Maryam

    2015-01-01

    Desmoplastic fibroma (DF) is a rare and locally aggressive intraosseous tumor with unknown etiology. The mandible is the common site of involvement in the maxillofacial region. However, it is believed that DF can arise in any bone of the body. A wide age distribution has been reported for DF occurrence, extending from birth to the sixth decade of life, with a peak incidence at 10 to 19 years of age. In this study, diagnostic and therapeutic management of a 6-year-old girl with a desmoplastic fibroma of the inferior orbital rim and zygomatic buttress are discussed. Cone beam computed tomography (CBCT) revealed a mixed lesion in infraorbital rim, which had ill-defined borders and a straight thick bony septum inside the lesion. It also involved the zygomatic process of maxilla and zygomatic bone. According to radiologic concepts, this rare lesion may mimic fibro-osseous, benign and especially malignant lesions. Regarding different treatment plans, identification of this lesion is essential. Furthermore, presence of coarse and irregular or straight septa along with some imaging criteria for malignant lesions such as destruction of the cortex, periosteal reaction and soft tissue invasion would be helpful to differentiate this lesion from malignant and multilocular benign lesions. PMID:26557283

  4. Three-dimensional trabecular bone architecture of the lumbar spine in bone metastasis from prostate cancer: comparison with degenerative sclerosis

    International Nuclear Information System (INIS)

    Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. The objective of this study was to clarify the three-dimensional (3D) trabecular bone microstructure in bone metastasis from prostate cancer by comparison with normal and degenerative sclerotic bone lesions, using microcomputed tomography (micro-CT). A total of 32 cancellous bone samples were excised from the lumbar spine of six autopsy patients: 15 metastatic samples (one patient), eight degenerative sclerotic samples (four patients) and the rest from normal sites (three patients). The samples were serially scanned cross-sectionally by micro-CT with a pixel size of 23.20 ?m, slice thickness of 18.56 ?m, and image matrix of 512 x 512. Each image data set consisted of 250 consecutive slices. The volumes of interest (96 x 96 x 120 voxels) were defined in the original image sets and 3D indices of the trabecular microstructure were determined. The trabecular thickness (Tb.Th) in degenerative sclerotic lesions was significantly higher than that in normal sites, whereas no significant difference was observed in trabecular number (Tb.N). By contrast, in metastatic lesions, the Tb.N was significantly higher with increased bone volume fraction (BV/TV) than in normal sites, and no significant difference was found in Tb.Th. The characteristics of the trabecular surface in the metastatic samples showed concave structural elements with an increase in BV/TV, indicating osteolysis of the trabecular bone. In 3D reconstructed images, increased trabecular bone with an irregular surface was observed in samples from metastatic sites, which were uniformly sclerotic on soft X-ray radiographs. These results support, through 3D morphological features, the strong bone resorption effect in bone metastasis from prostate cancer. (orig.)

  5. Beyond the peak of the anterior glenoid rim: A cadaveric study

    Directory of Open Access Journals (Sweden)

    Guillaume D Dumont

    2013-01-01

    Full Text Available Purpose: The purpose of this study was to quantify the width of bone beyond the peak of the anterior glenoid rim and to determine if this anatomic region of the glenoid significantly affects measurement of the anteroposterior glenoid diameter. Materials and Methods: 19 cadaveric scapulae were examined and the width of bone beyond the peak of the anterior glenoid rim was measured. The percent width of this region relative to the anteroposterior diameter of the glenoid was evaluated. Male and female specimens were compared. Measurements of the anteroposterior diameter of the glenoid, both including and excluding this region, were compared. Results: The mean width of bone beyond the peak of the anterior glenoid rim was 3.2 ± 0.7 mm, corresponding to 10.5% of the anteroposterior glenoid diameter. This anatomic region is of similar relative size in males and females (11% vs 10% of the glenoid diameter. Measurement of the anteroposterior diameter of the glenoid is significantly different depending on whether this region is included or not ( P = 0.0064. Conclusions: There exists a portion of the anterior glenoid that is beyond the peak of the anterior rim, and is not part of the concave articular surface. The width of this anatomic area comprises a significant percent of the anteroposterior glenoid diameter, and should be understood when quantifying and describing anterior glenoid bone loss in cases of glenohumeral instability. Clinical Relevance: Understanding of anterior glenoid anatomy is important in the evaluation of glenohumeral instability. The portion of glenoid bone beyond the anterior rim peak is likely important for its soft tissue attachments, but its contribution to bony stability may be misunderstood.

  6. Rim sign: association with acute cholecystitis

    International Nuclear Information System (INIS)

    In a retrospective analysis of 218 hepatobiliary studies in patients clinically suspected of acute cholecystitis, a rim of increased hepatic activity adjacent to the gallbladder fossa (the rim sign) has been evaluated as a scintigraphic predictor of confirmed acute cholecystitis. Of 28 cases with pathologic confirmation of acute cholecystitis in this series, 17 (60%) demonstrated this sign. When associated with nonvisualization of the gallbladder at 1 hr, the positive predictive value of this photon-intense rim for acute cholecystitis was 94%. When the rim sign was absent, the positive predictive value of nonvisualization of the gallbladder at 1 hr for acute cholecystitis was only 36%. As this sign was always seen during the first hour postinjection, it can, when associated with nonvisualization, reduce the time required for completion of an hepatobiliary examination in suspected acute cholecystitis

  7. Adaptation of subchondral bone in osteoarthritis

    DEFF Research Database (Denmark)

    Ding, Ming

    Osteoarthritis is a chronic joint disease with pathological changes in the articulating cartilage and all other tissues that occupy the joint. Radin and coworkers have suggested the involvement of subchondral bone in the disease process. However, evidence for an essential role in the etiology has...... adaptation might explain subchondral stiffening, a process where subchondral bone becomes typically sclerotic in osteoarthritis. In addition, we report reduced mechanical matrix tissue properties as well as an increase in denatured collagen content. In conclusion, although osteoarthritic bone tissue contains...

  8. Oscillating Rim Hook Tableaux and Colored Matchings

    CERN Document Server

    Chen, William Y C

    2011-01-01

    Motivated by the question of finding a type B analogue of the bijection between oscillating tableaux and matchings, we find a correspondence between oscillating m-rim hook tableaux and m-colored matchings, where m is a positive integer. An oscillating m-rim hook tableau is defined as a sequence $(\\lambda^0,\\lambda^1,...,\\lambda^{2n})$ of Young diagrams starting with the empty shape and ending with the empty shape such that $\\lambda^{i}$ is obtained from $\\lambda^{i-1}$ by adding an m-rim hook or by deleting an m-rim hook. Our bijection relies on the generalized Schensted algorithm due to White. An oscillating 2-rim hook tableau is also called an oscillating domino tableau. When we restrict our attention to two column oscillating domino tableaux of length 2n, we are led to a bijection between such tableaux and noncrossing 2-colored matchings on $\\{1, 2,..., 2n\\}$, which are counted by the product $C_nC_{n+1}$ of two consecutive Catalan numbers. A 2-colored matching is noncrossing if there are no two arcs of th...

  9. The Inner Rim Structures of Protoplanetary Discs

    CERN Document Server

    Kama, M; Dominik, C

    2009-01-01

    The inner boundary of protoplanetary discs is structured by the dramatic opacity changes at the transition from the dust-containing to a dust-free zone. This paper explores the variety and limits of inner rim structures in passively heated dusty discs. For this study, we implemented detailed sublimation physics in a fast Monte Carlo radiative transfer code. We show that the inner rim in dusty discs is not an infinitely sharp wall but a diffuse region which may be narrow or wide. Furthermore, high surface densities and large silicate grains as well as iron and corundum grains decrease the rim radius, from a 2.2AU radius for small silicates around a 47 Solar luminosity Herbig Ae star typically to 0.4AU and as close as 0.2AU. A passive disc with grain growth and a diverse dust composition must thus have a small inner rim radius. Finally, an analytical expression is presented for the rim location as a function of dust, disc and stellar properties.

  10. Dependence of rim pore radius on rim porosity and temperature behavior in the high burnup UO2 fuel

    International Nuclear Information System (INIS)

    The rim porosity at the high burnup UO2 fuel is obtained at the various rim pore radius ranging from 0.25 to 1.0 μm. The rim pore radius of 1.0 μm gives the best estimation for the rim porosity. With increasing the rim pore radius, thermal conductivity degrades with pellet average burnup because the rim pore acts as the thermal barrier. And by using the NEA database, the culculated fuel centerline temperature considering the rim effect is compared with the experimentally measured NEA database. The calculated temperature predicts reasonably well the temperature behavior of irradiated fuel

  11. Unusual Bilateral Rim Fracture in Femoroacetabular Impingement

    Science.gov (United States)

    Rafols, Claudio; Monckeberg, Juan Edo; Numair, Jorge

    2015-01-01

    This is a report of one case of bilateral acetabular rim fracture in association with femoroacetabular impingement (FAI), which was treated with a hip arthroscopic procedure, performing a partial resection, a labral reinsertion, and a subsequential internal fixation with cannulated screws. Up to date, there are in the literature only two reports of rim fracture and “os acetabuli” in association with FAI. In the case we present, the pincer and cam resection were performed without complications; the technique used was published previously. With this technique the head of the screw lays hidden by the reattached labrum. We removed partially the fractured rim fragment and the internal fixation of the remaining portion was achieved with a screw. In the event of a complete resection of the fragment, it would have ended with a LCE angle of 18° and a high probability of hip instability. We believe that this bilateral case helps establish the efficacy and reproducibility of the technique described by Larson. PMID:25722907

  12. Carcinoma medular do rim Renal medullary carcinoma

    Directory of Open Access Journals (Sweden)

    Paulo Guilherme de Oliveira Salles

    2006-04-01

    Full Text Available É relatado caso de paciente de 24 anos, portador de traço falciforme, com imagem sólida no rim direito, submetido a nefrectomia radical que revelou tumor, cujo exame anatomopatológico permitiu o diagnóstico de carcinoma medular do rim. Os autores discutem aspectos dessa neoplasia, tais como freqüência, patogênese, apresentação clínica, histopatologia e evolução.We report the case of a 24-year-old patient who presented a left kidney tumor that was diagnosed as a medullary renal cell carcinoma. The following aspects of this neoplasia are discussed in this communication: frequency, pathogenesis, clinical presentation, histopathological findings, differential diagnosis and follow-up.

  13. Rimmed and edge thickened Stodola shaped flywheel

    Science.gov (United States)

    Kulkarni, Satish V. (San Ramon, CA); Stone, Richard G. (Oakland, CA)

    1983-01-01

    A flywheel (10) is described that is useful for energy storage in a hybrid vehicle automotive power system or in some stationary applications. The flywheel (10) has a body (15) composed of essentially planar isotropic high strength material. The flywheel (10) body (15) is enclosed by a rim (50) of circumferentially wound fiber (2) embedded in resin (3). The rim (50) promotes flywheel (10) safety and survivability. The flywheel (10) has a truncated and edge thickened Stodola shape designed to optimize system mass and energy storage capability.

  14. Recent Astronomical Development in Asia Pacific Rim

    Science.gov (United States)

    Leung, K.-C.

    2009-08-01

    For over two decades The Pacific Rim Conference on Stellar Astrophysics series has been held exclusively at the Asian Rim. The primary reason is that the majority of nations in Asia are less developed in Astronomy than many countries on the American Rim. At time same time, many nations in Asia are less able to afford the costs of long distance travel for astronomical conferences. As a result Asia has had a hold on the Pacific Rim Conferences. Over the last few years new research institutes have been coming on board. The ones that have most visibly emerged are; National Astronomical Research Institute of Thailand, NARIT, The Astrophysical Research Center for the Structure and Evolution of the Cosmos, ARCSEC, and Kavli Institute of Astronomy and Astrophysics at Peking University, KIAA-PKU. It is interesting to note the development and structure of each is very different. So far they all appear to be working well. Hopefully they will provide a variety of models for astronomical institutes in developing nations of the region and perhaps beyond.

  15. Effects of rim thickness on spur gear bending stress

    Science.gov (United States)

    Bibel, G. D.; Reddy, S. K.; Savage, M.; Handschuh, R. F.

    1991-01-01

    Thin rim gears find application in high-power, light-weight aircraft transmissions. Bending stresses in thin rim spur gear tooth fillets and root areas differ from the stresses in solid gears due to rim deformations. Rim thickness is a significant design parameter for these gears. To study this parameter, a finite element analysis was conducted on a segment of a thin rim gear. The rim thickness was varied and the location and magnitude of the maximum bending stresses reported. Design limits are discussed and compared with the results of other researchers.

  16. Echogenic rim of hepatic hemangioma on abdominal ultrasound

    International Nuclear Information System (INIS)

    To investigate the association between the size of the hepatic hemangioma and the shape and thickness of the echogenic rim of hepatic hemangioma on abdominal ultrasound. We examined 47 cases (M:F=24:23, mean age 47.1) of hepatic hemangiomas with echogenic rim on abdominal ultrasound during the past 2 years. Radiologic findings were retrospectively reviewed in terms of completeness and thickness of echogenic rim. If echogenic rim showed even thickness, it was measured. But if not, the maximum and minimum thickness of the rim was measured. The association between the size of hemangioma and the completeness and thickness of the echogenic rim were analyzed statistically. Of the 47 cases, complete echogenic rim and incomplete echogenic rim were obtained in 29 (62%) and 18 (38%) cases, respectively. Twenty-two cases of hemangioma were less than 2 cm in diameter, and their distribution according to echogenic rim were as follows: complete echogenic rim (17/20, 91% mean thickness 2.2 cm) and uneven thickness with complete echogenic rim (3/20, 15%, range:2.0-6.1 mm). Twenty-five hemangiomas were larger than 2 cm in diameter and their distribution according to echogenic rim were as follows: complete echogenic rim (n=9, 34%), incomplete echogenic rim (n=16, 64%0,even thickness with complete echogenic rim (3/9, 33%, mean thickness 2.2 mm) and uneven thickness with complete echogenic rim (6/9,67%, range: 2.0-7.6 mm). In statistical analysis, hemangiomas more than 2 cm in diameter were more likely to have incomplete echogenic rim (p<0.05) than those of less than 2 cm; hemangiomas more than with more than 2 cm in diameter and complete echogenic rim showed uneven thickness of echogenic rim (p<0.05), more often than those of less than 2 cm diameter. Hemangiomas with more than 2 cm in diameter showed more frequent incomplete echogenic rim than those of less than 2 cm in diameter, which had more frequent complete echogenic rim. Hemangiomas with complete echogenic rim and even rim thickness were more prevalent in those with less than 2 cm in diameter. Uneven rim thickness was present more often in those with more than 2 cm in diameter.

  17. Reaction kinetics of dolomite rim growth

    Science.gov (United States)

    Helpa, V.; Rybacki, E.; Abart, R.; Morales, L. F. G.; Rhede, D.; Je?ábek, P.; Dresen, G.

    2014-04-01

    Reaction rims of dolomite (CaMg[CO3]2) were produced by solid-state reactions at the contacts of oriented calcite (CaCO3) and magnesite (MgCO3) single crystals at 400 MPa pressure, 750-850 °C temperature, and 3-146 h annealing time to determine the reaction kinetics. The dolomite reaction rims show two different microstructural domains. Elongated palisades of dolomite grew perpendicular into the MgCO3 interface with length ranging from about 6 to 41 µm. At the same time, a 5-71 µm wide rim of equiaxed granular dolomite grew at the contact with CaCO3. Platinum markers showed that the original interface is located at the boundary between the granular and palisade-forming dolomite. In addition to dolomite, a 12-80 µm thick magnesio-calcite layer formed between the dolomite reaction rims and the calcite single crystals. All reaction products show at least an axiotactic crystallographic relationship with respect to calcite reactant, while full topotaxy to calcite prevails within the granular dolomite and magnesio-calcite. Dolomite grains frequently exhibit growth twins characterized by a rotation of 180° around one of the equivalent axis. From mass balance considerations, it is inferred that the reaction rim of dolomite grew by counter diffusion of MgO and CaO. Assuming an Arrhenius-type temperature dependence, activation energies for diffusion of CaO and MgO are E a (CaO) = 192 ± 54 kJ/mol and E a (MgO) = 198 ± 44 kJ/mol, respectively.

  18. Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis

    Directory of Open Access Journals (Sweden)

    V Silva

    2007-01-01

    Full Text Available Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Quinck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones.A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, diagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

  19. Adjuvant therapies of bone graft around non-cemented experimental orthopedic implants stereological methods and experiments in dogs

    DEFF Research Database (Denmark)

    Baas, Jørgen

    2008-01-01

    Revision arthroplasty is a challenging aspect of the otherwise quite successful area of joint replacement surgery. The instable interaction between implant and host bone has often initiated a destructive process of inflammation and osteolysis, rendering the revision site sclerotic and with insufficient bone stock. One way of dealing with this is to build up a bed of tightly packed morselized bone graft to support the revision implant in a procedure often referred to as impaction grafting. Fresh ...

  20. Ciclamato de sódio e rim fetal

    OpenAIRE

    Arruda José Germano Ferraz de; Martins Alex Tadeu; Azoubel Reinaldo

    2003-01-01

    O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O ciclamato e a ciclohexilamina, seu principal metabólito, atravessam a barreira placentária em humanos e desse modo podem ser expostos ao feto. O rim de ratos pode ser afetado por elevadas doses de ciclamato de sódio. Estudos sobre ef...

  1. Rim Sim: A Role-Play Simulation

    Science.gov (United States)

    Barrett, Robert C.; Frew, Suzanne L.; Howell, David G.; Karl, Herman A.; Rudin, Emily B.

    2003-01-01

    Rim Sim is a 6-hour, eight-party negotiation that focuses on creating a framework for the long-term disaster-recovery efforts. It involves a range of players from five countries affected by two natural disasters: a typhoon about a year ago and an earthquake about 6 months ago. The players are members of an International Disaster Working Group (IDWG) that has been created by an international commission. The IDWG has been charged with drawing up a framework for managing two issues: the reconstruction of regionally significant infrastructure and the design of a mechanism for allocating funding to each country for reconstruction of local infrastructure and ongoing humanitarian needs. The first issue will involve making choices among five options (two harbor options, two airport options, and one rail-line option), each of which will have three levels at which to rebuild. The second issue will involve five starting-point options. Participants are encouraged to invent other options for both issues. The goal of Rim Sim is to raise questions about traditional approaches to disaster-preparedness planning and reconstruction efforts in an international setting, in this case the Pacific Rim. Players must confront the reverberating effects of disasters and the problems of using science and technical information in decisionmaking, and are introduced to a consensus-building approach emphasizing face-to-face dialog and multinational cooperation in dealing with humanitarian concerns, as well as long-term efforts to reconstruct local and regional infrastructure. The Rim Sim simulation raises four key points: ripple effects of disasters, role of science, multiparty negotiation, and building personal relationships.

  2. Osteoid osteoma of a metacarpal bone: A case report and review of the literature

    OpenAIRE

    Chronopoulos Efstathios; Xypnitos Fragiskos N; Nikolaou Vassilios S; Efstathopoulos Nicolas; Korres Dimitrios

    2008-01-01

    Abstract Introduction Osteoid osteoma is a benign tumor of the growing skeleton. It presents with pain, which is usually worse at night. The radiographic features consist of a central oval or round nidus surrounded first by a radiolucent area followed by another area of sclerotic bone. In the hand, osteoid osteoma is more commonly located in the phalanges and carpal bones. The metacarpals are the least common sites for osteoid osteoma. Case presentation We present a case of an osteoid osteoma...

  3. The nature and origin of rims on lunar soil grains

    Science.gov (United States)

    Keller, Lindsay P.; McKay, David S.

    1997-06-01

    Space weathering processes that operate in the lunar regolith modify the surfaces of lunar soil grains. Transmission electron microscope analysis of the lunar soil grains from the fine size fraction of several lunar soils show that most grains are surrounded by thin (60-200 nm thick) rims. The microstructure and chemical compositions of the rims can be used to classify rims into four broad categories: amorphous, inclusion-rich, multiple, and vesicular. Amorphous rims are noncrystalline, generally lack crystalline inclusions, show evidence for preferential sputtering of cations, and are produced largely by solar-wind irradiation damage. Inclusion-rich rims contain abundant nanometer-sized grains of Fe metal as randomly dispersed inclusions or as distinct layers embedded in an amorphous silica-rich matrix. Inclusion-rich rims are compositionally distinct from their host grains and typically contain accumulations of elements that are not indigenous to the host. Inclusion-rich rims are formed largely by the deposition of impact-generated vapors with a contribution from the deposition of sputtered ions. A continuum in the chemical and microstructural properties exists between typical amorphous rims and typical inclusion-rich rims. Multiple-rims consist of a distinct radiation-damaged layer up to 50 nm thick, that is overlain by vapor-deposited material of comparable thickness. Vesicular rims are compositionally similar to their hosts and are characterized by an abundance of small (effects may be superimposed. From this study, it is shown that one process does not dominate and that the relative importance of vapor-deposition is comparable to radiation-damage in the formation of rims on lunar silicate grains. The presence of rims on lunar soil grains, particularly those with nanometer-sized Fe metal inclusions, may have a major influence on the optical and magnetic properties of lunar soils.

  4. Bleomycin-induced epithelial–mesenchymal transition in sclerotic skin of mice: Possible role of oxidative stress in the pathogenesis

    International Nuclear Information System (INIS)

    Epithelial–mesenchymal transition (EMT) derived myofibroblasts are partly responsible for the increased collagen synthesis and deposition that occur in tissue fibrosis; however EMT occurrence in skin fibrosis and its mechanism remain unknown. The aim of this study was to investigate whether epithelial cells undergo EMT and determine the role of oxidative stress in this process. BALB/c mice were subcutaneously injected with bleomycin (BLM) or phosphate buffer saline (PBS) into the shaved back daily for 2, 3, and 4 weeks. Skin collagen deposition was evaluated by histopathology and Western blotting. EMT characteristics in the skin were determined by histopathology and immunofluorescent staining for E-cadherin and vimentin, which were further evaluated by Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR). To investigate the role of oxidative stress in EMT, the antioxidant N-acetylcysteine (NAC) was intraperitoneally (100 mg/kg body weight/day) injected daily for 3 weeks. The epithelial suprabasal cells were detached from the basement membrane zone (BMZ) in the sclerotic skin treated with BLM. Immunofluorescent staining indicated vimentin-positive epithelial cells frequently occurring in the thickened epidermis of BLM-treated mice. Western blotting and RT-PCR showed that the expression of E-cadherin was significantly decreased but that of vimentin significantly increased in the skin treated with BLM. NAC attenuated BLM induced oxidative damage, changes in E-cadherin and vimentin expressions and collagen deposition in the sclerotic skin of mice. This study provides the first evidence that BLM induces the EMT of the epithelial cells superficial to the basement membrane zone in the skin fibrosis. Oxidative stress may contribute, at least in part, to BLM induced EMT and skin fibrosis in mice. - Highlights: • We provided the first evidence that EMT occurred in BLM-induced skin fibrosis. • Epithelial cells superficial to the BMZ underwent EMT in BLM-induced skin fibrosis. • NAC attenuated EMT induction in the process of BLM-induced skin fibrosis. • NAC didn't significantly inhibit TGF-β expression in BLM-induced skin fibrosis

  5. Rim intratorácico ectópico Thoracic ectopic kidney

    Directory of Open Access Journals (Sweden)

    Claudinei Leôncio Beraldo

    2005-04-01

    Full Text Available O rim ectópico intratorácico é uma anomalia rara. De todas as ectopias renais é a mais rara (p = 0,005%. Relata-se um caso de ectopia renal intratorácica em um homem negro de 83 anos, que procurou atendimento médico com quadro clínico compatível com enfisema pulmonar. Foi solicitado radiograma de tórax, que evidenciou uma massa, diagnosticada por tomografia computadorizada como ectopia renal. A maioria dos casos de rim torácico aparece como uma tumoração intratorácica encontrada em radiogramas de tórax solicitados por qualquer outra razão alheia à suspeita dessa anomalia, e não necessita de tratamento específico.Thoracic ectopic kidney is a rare anomaly, the rarest of all renal ectopia types (p = 0.005%. Herein, we describe a case of thoracic ectopic kidney in an 83-year-old black man who, upon seeking medical attention, presented a clinical profile consistent with pulmonary emphysema. A chest X-ray was ordered, and the results showed evidence of a mass, which was then diagnosed (through computed tomography as renal ectopia. The majority of thoracic ectopic kidney cases present as an intrathoracic tumor seen on chest X-rays ordered for reasons other than suspicion of this anomaly and do not require special treatment.

  6. Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea / Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis

    Scientific Electronic Library Online (English)

    V, Silva; H, Madrid; S, Anticevic.

    Full Text Available Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Qui [...] nck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones. Abstract in english A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, d [...] iagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

  7. Measurement of wheel rim wear on railway wheels using radioisotopes

    International Nuclear Information System (INIS)

    A radioisotopic measuring method developed for studying the wear process of wheel rims of railway vehicles is described. The wear process may be monitored by the measurement of activity of a thin galvanic layer deposited onto the rim and labelled by iron 59. The high sensitivity of the method allows the determination of the wear rate distribution even within a few days. The results of measurements on three different rim profiles are analysed. (R.J.)

  8. Aquaporin-4 expression in distal myopathy with rimmed vacuoles

    OpenAIRE

    Hoshi Akihiko; Yamamoto Teiji; Kikuchi Saeko; Soeda Tomoko; Shimizu Keiko; Ugawa Yoshikazu

    2012-01-01

    Abstract Background Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles. To date, the role of aquaporin-4 water channel in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy has not been studied. Case presentation Here, we studied the expression of aquaporin-4 in muscle fibers of a patient...

  9. Aquaporin-4 expression in distal myopathy with rimmed vacuoles

    Directory of Open Access Journals (Sweden)

    Hoshi Akihiko

    2012-04-01

    Full Text Available Abstract Background Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles. To date, the role of aquaporin-4 water channel in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy has not been studied. Case presentation Here, we studied the expression of aquaporin-4 in muscle fibers of a patient with distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy. Immunohistochemical and immunofluorescence analyses showed that sarcolemmal aquaporin-4 immunoreactivity was reduced in many muscle fibers of the patient. However, the intensity of aquaporin-4 staining was markedly increased at rimmed vacuoles or its surrounding areas and in some muscle fibers. The fast-twitch type 2 fibers were predominantly involved with the strong aquaporin-4-positive rimmed vacuoles and TAR-DNA-binding protein-43 aggregations. Rimmed vacuoles with strong aquaporin-4 expression seen in the distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy patient were not found in control muscles without evidence of neuromuscular disorders and the other disease-controls. Conclusions Aquaporin-4 might be crucial in determining the survival or degeneration of fast-twitch type 2 fibers in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy.

  10. Candida albicans Rim13p, a Protease Required for Rim101p Processing at Acidic and Alkaline pHs

    OpenAIRE

    Li, Mingchun; Martin, Samuel J.; Bruno, Vincent M; Mitchell, Aaron P.; Davis, Dana A

    2004-01-01

    Candida albicans is an important commensal of mucosal surfaces that is also an opportunistic pathogen. This organism colonizes a wide range of host sites that differ in pH; thus, it must respond appropriately to this environmental stress to survive. The ability to respond to neutral-to-alkaline pHs is governed in part by the RIM101 signal transduction pathway. Here we describe the analysis of C. albicans Rim13p, a homolog of the Rim13p/PalB calpain-like protease member of the RIM101/pacC path...

  11. Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin

    Directory of Open Access Journals (Sweden)

    Alexandra Patricia Mena-Serrano

    2013-04-01

    Full Text Available Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI, the 2-step self-etch Adper SE Bond (3MESPE and the 35% phosphoric acid (3MESPE from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE were applied on the bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm 2 and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment, according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05. Results: The duplication of the conditioning time favored only the GO adhesive (p<0.05. Both application methods significantly increased the tubule area opening (p<0.05 compared to the controls. Conclusions: The efficacy of duplicating the conditioning time was only effective for the 1-step self-etch adhesive system tested.

  12. Rim for rotary inertial energy storage device and method

    Science.gov (United States)

    Knight, Jr., Charles E. (Knoxville, TN); Pollard, Roy E. (Powell, TN)

    1980-01-01

    The present invention is directed to an improved rim or a high-performance rotary inertial energy storage device (flywheel). The improved rim is fabricated from resin impregnated filamentary material which is circumferentially wound in a side-by-side relationship to form a plurality of discretely and sequentially formed concentric layers of filamentary material that are bound together in a resin matrix. The improved rim is provided by prestressing the filamentary material in each successive layer to a prescribed tension loading in accordance with a predetermined schedule during the winding thereof and then curing the resin in each layer prior to forming the next layer for providing a prestress distribution within the rim to effect a self-equilibrating compressive prestress within the windings which counterbalances the transverse or radial tensile stresses generated during rotation of the rim for inhibiting deleterious delamination problems.

  13. A simplified procedure for preparation of undecalcified human bone sections

    DEFF Research Database (Denmark)

    Wallin, J A; Tkocz, I; Levinsen, J

    1985-01-01

    A new type of apparatus for sectioning samples of hard, undecalcified bone is described. Slices of fresh or archeological human bone 4-5 mm thick are dehydrated and then embedded in epoxy resin. The apparatus used to prepare sections from the resulting blocks consists of a low-speed rim-type diam......A new type of apparatus for sectioning samples of hard, undecalcified bone is described. Slices of fresh or archeological human bone 4-5 mm thick are dehydrated and then embedded in epoxy resin. The apparatus used to prepare sections from the resulting blocks consists of a low-speed rim...

  14. Bone tumors with an associated pathologic fracture: Differentiation between benign and malignant status using radiologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Ji Hyun; Lee, In Sook; Song, You Seon [Pusan National University School of Medicine, Pusan National University Hospital, Busan (Korea, Republic of); Kim, Jeung Il [Dept. of Radiology, Yeungnam University College of Medicine, Yeungnam University Medical Center, Daegu (Korea, Republic of); Lee, Moon Sung [Dept. of Radiology, Keimyung University College of Medicine, Dongsan Medical Center, Daegu (Korea, Republic of); Lee, Young Hwan [Dept. of Radiology, Catholic University of Daegu College of Medicine, Daegu Catholic University Hospital, Daegu (Korea, Republic of); Song, Jong Woon [Dept. of Radiology, Inje University College of Medicine, Haeundae Paik Hospital, Busan (Korea, Republic of)

    2015-10-15

    To determine whether benign and malignant bone tumors with associated pathologic fractures can be differentiated using radiologic findings. Seventy-eight patients (47 men and 31 women, age range: 1-93 years) with a bone tumor and an associated pathologic fracture from 2004 to 2013 constituted the retrospective study cohort. The tumor size, margin, and enhancement patterns; the presence of sclerotic margin, the peritumoral bone marrow, soft tissue edema, extra-osseous soft tissue mass, intratumoral cystic/hemorrhagic/necrotic regions, mineralization/sclerotic regions, periosteal reaction and its appearance; and cortical change and its appearance were evaluated on all images. Differences between the imaging characteristics of malignant and benign pathologic fractures were compared using Pearson's chi-square test and the 2-sample t-test. There were 22 benign and 56 malignant bone tumors. Some factors were found to significantly differentiate between benign and malignant tumors; specifically, ill-defined tumor margin, the presence of sclerotic tumor margin and an extra-osseous soft tissue mass, the absence of cystic/necrotic/hemorrhagic portions in a mass, the homogeneous enhancement pattern, and the presence of a displaced fracture and of underlying cortical change were suggestive of malignant pathologic fractures. Some imaging findings were helpful for differentiating between benign and malignant pathologic fractures.

  15. Bone tumors with an associated pathologic fracture: Differentiation between benign and malignant status using radiologic findings

    International Nuclear Information System (INIS)

    To determine whether benign and malignant bone tumors with associated pathologic fractures can be differentiated using radiologic findings. Seventy-eight patients (47 men and 31 women, age range: 1-93 years) with a bone tumor and an associated pathologic fracture from 2004 to 2013 constituted the retrospective study cohort. The tumor size, margin, and enhancement patterns; the presence of sclerotic margin, the peritumoral bone marrow, soft tissue edema, extra-osseous soft tissue mass, intratumoral cystic/hemorrhagic/necrotic regions, mineralization/sclerotic regions, periosteal reaction and its appearance; and cortical change and its appearance were evaluated on all images. Differences between the imaging characteristics of malignant and benign pathologic fractures were compared using Pearson's chi-square test and the 2-sample t-test. There were 22 benign and 56 malignant bone tumors. Some factors were found to significantly differentiate between benign and malignant tumors; specifically, ill-defined tumor margin, the presence of sclerotic tumor margin and an extra-osseous soft tissue mass, the absence of cystic/necrotic/hemorrhagic portions in a mass, the homogeneous enhancement pattern, and the presence of a displaced fracture and of underlying cortical change were suggestive of malignant pathologic fractures. Some imaging findings were helpful for differentiating between benign and malignant pathologic fractures

  16. Visual illusions and plate design: The effects of plate rim widths and rim coloring on perceived food portion size

    Science.gov (United States)

    McClain, Arianna; van den Bos, Wouter; Matheson, Donna; Desai, Manisha; McClure, Samuel M.; Robinson, Thomas N.

    2013-01-01

    OBJECTIVE The Delboeuf Illusion affects perceptions of the relative sizes of concentric shapes. This study was designed to extend research on the application of the Delboeuf illusion to food on a plate by testing whether a plate’s rim width and coloring influence perceptual bias to affect perceived food portion size. DESIGN AND METHODS Within-subjects experimental design. Experiment 1 tested the effect of rim width on perceived food portion size. Experiment 2 tested the effect of rim coloring on perceived food portion size. In both experiments, participants observed a series of photographic images of paired, side-by-side plates varying in designs and amounts of food. From each pair, participants were asked to select the plate that contained more food. Multi-level logistic regression examined the effects of rim width and coloring on perceived food portion size. RESULTS Experiment 1: Participants overestimated the diameter of food portions by 5% and the visual area of food portions by 10% on plates with wider rims compared to plates with very thin rims (Peffect of rim width was greater with larger food portion sizes. Experiment 2: Participants overestimated the diameter of food portions by 1.5% and the visual area of food portions by 3% on plates with rim coloring compared to plates with no coloring (P=0.01). The effect of rim coloring was greater with smaller food portion sizes. CONCLUSION The Delboeuf illusion applies to food on a plate. Participants overestimated food portion size on plates with wider and colored rims. These findings may help design plates to influence perceptions of food portion sizes. PMID:24005858

  17. Cholescintigraphic findings of acute cholecystitis emphasized on the rim sign

    International Nuclear Information System (INIS)

    Nonvisualization of gallbladder in cholescintigraphy has been established to be a major and reliable finding for acute cholecystitis. A rim of increased pericholecystic hepatic activity (PCHA or Rim sign) in conjunction with gallbladder nonvisualization was reported to be secondary sign of acute cholecystitis. To determine the frequency and significance of the pericholecystic hepatic activity, we evaluated 217 cholescintigram in patients clinically suspected of acute cholecystitis. After brief review of cholescintigraphic findings of acute cholecystitis, the significance of the Rim sign is described. 1) The frequency of the Rim sign in surgically proved acute cholecystitis was 14.9%. 2) The frequency of Rim sign in complicated acute cholecystitis including gallbladder empyema and/or pericholecystic abscess (7/22) and in noncomplicated acute cholecystitis (3/45) was 31.8%, 6.6% respectively. The present study suggests that the Rim sign appear to indicate relatively high incidence of complicated acute cholecystitis and effort should be made observing the presence of the Rim sign in cholescintigraphy.

  18. Business Strategy Analysis of RIM in China's Smartphone Industry

    OpenAIRE

    Chen, Lei

    2011-01-01

    China, the biggest mobile phone market in the world, is crucial for the future of Research In Motion (RIM). While RIM entered China’s market in 2006, its market share is still very small in China. The launch of 3G amid the restructuring of China’s telecom industry proved crucial to the company’s development. RIM has partnered with all mobile operators in China to provide BlackBerry Enterprise Service and BlackBerry Internet Service to both business and individual users. It has gained a compet...

  19. Learning from California and the Pacific Rim

    International Nuclear Information System (INIS)

    Heavy oils are found in 10 of the 14 largest oilfields in Alaska and California. In the US west coast region, petroleum demand is dominated by light transport fuels, and there is a lack of a discrete and conspicuous heavy oil market. The structure and behavior of west coast petroleum markets, and their interactions with crude-oil and petroleum product markets elsewhere on the Pacific Rim are discussed with regard to how the market for growing volumes of western Canadian heavy oils might evolve. An analysis of crude oil prices versus API gravity demonstrates the price penalties on oil of low gravity, high sulfur, and high transport cost. Prices at the high gravity end tend to correlate closely with Asian light crude and unfinished gasoline prices. The heaviest crudes are priced in competition with other chemically similar residual oils for direct fuel use, blending, or refinery feedstock. The biggest component of the west coast heavy oil market is bunker fuel. The market value of heavy crudes in the west coast is thus determined by regional supply and demand for heavy hydrocarbon molecules, whatever the source. The west coast is not a promising market for Canadian heavy crudes, and exports to Asia would have to compete both with residual oils from Asia and the US west coast and with California heavy crudes. US west coast production peaked in 1989 and regional production can be expected to decline further in average gravity. New production from known but undeveloped heavy oil pools near Prudhoe Bay or in the California offshore could be expected to postpone the need for imports to the west coast and to depress prices. A removal of the Alaska crude oil export ban could improve the west coast heavy oil market. 5 refs., 2 figs., 1 tab

  20. A new flea, Ectinorus (Ectinorus) insignis n. sp. (Siphonaptera, Rhopalopsyllidae, Parapsyllinae), with notes on the subgenus Ectinorus in Chile and comments on unciform sclerotization in the superfamily Malacopsylloidea.

    Science.gov (United States)

    Beaucournu, Jean-Claude; Belaz, Sorya; Muñoz-Léal, Sebastián; González-Acuña, Daniel

    2013-01-01

    A list is provided for the species of Ectinorus sensu stricto from Chile. Ectinorus (Ectinorus) insignis n. sp. is described from Chile: this species is characterized by the male genitalia. In the subgenus Ectinorus, the authors report the presence in Chile of E. pilosus Beaucournu & Carmen Castro, 2002 described from Argentina and E. simonsi (Rothschild, 1904) described from Bolivia but also known from Peru. A female neallotype is designated for E. ineptus Johnson, 1957. "Unciform sclerotization" is noted and illustrated for the first time, in all Malacopsylloidea, and a list is given for all studied species. PMID:24125080

  1. A new flea, Ectinorus (Ectinorus) insignis n. sp. (Siphonaptera, Rhopalopsyllidae, Parapsyllinae), with notes on the subgenus Ectinorus in Chile and comments on unciform sclerotization in the superfamily Malacopsylloidea

    Science.gov (United States)

    2013-01-01

    A list is provided for the species of Ectinorus sensu stricto from Chile. Ectinorus (Ectinorus) insignis n. sp. is described from Chile: this species is characterized by the male genitalia. In the subgenus Ectinorus, the authors report the presence in Chile of E. pilosus Beaucournu & Carmen Castro, 2002 described from Argentina and E. simonsi (Rothschild, 1904) described from Bolivia but also known from Peru. A female neallotype is designated for E. ineptus Johnson, 1957. “Unciform sclerotization” is noted and illustrated for the first time, in all Malacopsylloidea, and a list is given for all studied species. PMID:24125080

  2. Hemangioendotelioma Hepático Infantil e Rim Displásico Multiquístico: uma nova associação?

    Directory of Open Access Journals (Sweden)

    M. Carneiro de Moura

    2009-03-01

    Full Text Available O hemangioendotelioma hepático infantil tem uma incidência que é a terceira entre os tumores hepáticos da criança e é o tumor benigno hepático vascular mais frequente na infância. Apresentamos o caso clínico de uma criança com o diagnóstico de hemangioendotelioma hepático associado a rim displásico multiquístico transitório. O diagnóstico de rim multiquístico foi confirmado por ecografia no período pré e pós natal. Numa ecografia realizada aos 5 meses detectaram-se lesões hepáticas sugestivas de hemangioendotelioma. Realizou ressonância magnética aos 8 meses que não mostrou o rim direito. A biópsia hepática confirmou o diagnóstico de hemangioendotelioma infantil tipo1. Em ecografias seriadas verificou-se redução das lesões hepáticas que desapareceram aos 19 meses. Esta associação de hemangioendotelioma hepático e rim multiquístico não se encontra descrita, embora sejam conhecidas associações com agenesia renal.

  3. Rimmed and edge thickened stodola shaped flywheel. [Patent application

    Science.gov (United States)

    Kulkarni, S.V.; Stone, R.G.

    1980-09-24

    A flywheel is described that is useful for energy storage in a hybrid vehicle automotive power system or in some stationary applications. The flywheel has a body composed of essentially planar isotropic high strength material. The flywheel body is enclosed by a rim of circumferentially wound fiber embedded in resin. The rim promotes flywheel safety and survivability. The flywheel has a truncated and edge thickened Stodola shape designed to optimize system mass and energy storage capability.

  4. A STUDY OF HAEMOGLOBIN PATTERNS AMONG THE STUDENTS OF RIMS

    OpenAIRE

    Urmila; Sunita,; Mohen Singh; Durlav Chandra

    2015-01-01

    Haemoglobinopathies are a major health problem worldwide. Because of the high prevalence of these disorders in India and especially in North–East, we undertook this limited student based study as RIMS comprised students from the seven North-East states of Arunachal Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Sikkim and Tripura. AIMS: To study the prevalence of haemoglobin variants among the North-East students of RIMS and to find out any abnormal haemoglobin pattern pertai...

  5. Rim instability in dewetting of thin polymer films

    OpenAIRE

    Marquant, Ludovic

    2013-01-01

    Understanding flow properties at the solid/liquid interface is important for numerous of technological applications in nanotechnology and microfluidic. The strong scientific interest in the field of thin liquid films led to new conclusions on the impact of hydrodynamic slippage on the dewetting dynamics and on the shape of the rim growing at the three phase contact line. This work consists of verifying the validity of these findings at late stage of dewetting, i.e. while the rim instabilit...

  6. Novel Multiband Metal-Rimmed Antenna for Wearable Applications

    OpenAIRE

    Bin Liu; Jianghong Han; Songhua Hu; Li De Zhang

    2015-01-01

    A novel multiband antenna with an unbroken metal rim for wearable applications is presented. In order to achieve a wideband behavior, minimizing at the same time the size of the clearance area on the antenna ground plane, a novel feeding structure is proposed. This is achieved by connecting the metal rim to the ground plane thus allowing generating one lower-frequency resonance without occupying a large area. An additional resonance is then obtained using a suitable shorting patch. In this wa...

  7. The natural history of disappearing bone tumours and tumour-like conditions

    International Nuclear Information System (INIS)

    We describe 27 cases of bone tumours or tumour-like lesions where there was spontaneous regression. The follow-up period was 2.8-16.7 years (average, 7.0 years). Fourteen of these cases were no longer visible on plain radiographs. Histological diagnosis included exostosis, eosinophilic granuloma, fibrous dysplasia, fibrous cortical defect, non-ossifying fibroma, osteoid osteoma and bone island. Most cases began to reduce in adolescence or earlier, although sclerotic type lesions showed their regression in older patients. All lesions thought to be eosinophilic granuloma began to regress after periods of less than 3 months, while the duration of the other lesions showed wide variation (1-74 months). As resolution of the lesions took between 2 and 79 months (mean, 25.0 ± 20.3 months) we consider that the most likely mechanism was recovery of normal skeletal growth control. In exostosis with fracture, alteration of vascular supply may contribute to growth arrest, but not to subsequent remodelling stage. In inflammatory-related lesions such as eosinophilic granuloma, cessation of inflammation may be the mechanism of growth arrest, whilst temporary inflammation may stimulate osteogenic cells engaged in remodeling. In the sclerotic type, growth arrest is a less probable mechanism. Necrosis within the tumour and/or local changes in hormonal control, plus remodelling of the sclerotic area takes longer. Knowledge of the potential for spontaneous resolution may help in management of these tumour and tumour-like lesions of bone. Yanagawa, T. et al. (2001)

  8. The natural history of disappearing bone tumours and tumour-like conditions

    Energy Technology Data Exchange (ETDEWEB)

    Yanagawa, Takashi; Watanabe, Hideomi; Shinozaki, Tetsuya; Ahmed, Adel Refaat; Shirakura, Kenji; Takagishi, Kenji

    2001-11-01

    We describe 27 cases of bone tumours or tumour-like lesions where there was spontaneous regression. The follow-up period was 2.8-16.7 years (average, 7.0 years). Fourteen of these cases were no longer visible on plain radiographs. Histological diagnosis included exostosis, eosinophilic granuloma, fibrous dysplasia, fibrous cortical defect, non-ossifying fibroma, osteoid osteoma and bone island. Most cases began to reduce in adolescence or earlier, although sclerotic type lesions showed their regression in older patients. All lesions thought to be eosinophilic granuloma began to regress after periods of less than 3 months, while the duration of the other lesions showed wide variation (1-74 months). As resolution of the lesions took between 2 and 79 months (mean, 25.0 {+-} 20.3 months) we consider that the most likely mechanism was recovery of normal skeletal growth control. In exostosis with fracture, alteration of vascular supply may contribute to growth arrest, but not to subsequent remodelling stage. In inflammatory-related lesions such as eosinophilic granuloma, cessation of inflammation may be the mechanism of growth arrest, whilst temporary inflammation may stimulate osteogenic cells engaged in remodeling. In the sclerotic type, growth arrest is a less probable mechanism. Necrosis within the tumour and/or local changes in hormonal control, plus remodelling of the sclerotic area takes longer. Knowledge of the potential for spontaneous resolution may help in management of these tumour and tumour-like lesions of bone. Yanagawa, T. et al. (2001)

  9. Southern rim of Isidis Planitia basin

    Science.gov (United States)

    2002-01-01

    (Released 11 April 2002) The Science This image, crossing the southern rim of the Isidis Planitia basin, displays the contrasting morphologies of the relatively rough highland terrain (in the lower portion of the image) and the relatively smooth materials of the basin (at top). Upon closer viewing, the basin materials display an extensive record of cratering, including a small cluster of craters just north and west of the two prominent craters in the upper part of the image. This cluster of craters may represent what are called 'secondary' craters, which are craters that form as a result of the ejection of debris from a nearby impact. Alternatively, these craters may have formed simultaneously by the impact of many pieces of a larger meteoroid that broke up upon entry into Mars' atmosphere. The large craters in the image are approximately 800 meters (875 yards) in diameter. Also visible in the image are dark streaks on the east-facing side of the north-south trending ridge. These streaks are likely the result of debris movement down slope. A dark patch of material is visible at the left of the image; dark materials are typically mobile sands, and linear dune forms are apparent within the dark patch. The Story Battered and beaten up, the surface of Mars reads like a history book to geologists, who want to study what has happened to the red planet over its geological history. Look for two larger craters diagonal from one another in the northern part of this image, and then for the smattering of tinier craters near them. How did these smaller craters come to be? Did a large meteoroid streak in through the Martian atmosphere and get broken up as it passed through, pummeling Mars moments later with its smaller, scattered pieces? Or were rocks and dirt blasted off the surface when the two larger craters were formed, only to rain down again on Mars shortly afterwards? No one quite knows for sure.... Another enigmatic-looking feature is near the left center of this image. Dark and shadowy-seeming, it looks something like an exclamation point with the small crater just below it. Look closely, and you'll see dunes within the large, dark, blurry patch, which is itself probably composed of moving sands. Dark, streaky features also appear on the eastern side of the ridge that runs down the right side of the image, showing how debris once tumbled down its steepened slopes.

  10. Rim region growth and its composition in reaction bonded boron carbide composites with core-rim structure

    International Nuclear Information System (INIS)

    Aluminum was detected in reaction-bonded boron carbide that had been prepared by pressureless infiltration of boron carbide preforms with molten silicon in a graphite furnace under vacuum. The presence of Al2O3 in the heated zone, even though not in contact with the boron carbide preform, stands behind the presence of aluminium in the rim region that interconnects the initial boron carbide particles. The composition of the rim corresponds to the Bx(C,Si,Al)y quaternary carbide phase. The reaction of alumina with graphite and the formation of a gaseous aluminum suboxide (Al2O) accounts for the transfer of aluminum in the melt and, subsequently in the rim regions. The presence of Al increases the solubility of boron in liquid silicon, but with increasing aluminum content the activity of boron decreases. These features dominate the structural evolution of the rim-core in the presence of aluminum in the melt.

  11. Histologia e ultraestrutura do rim e rim cefálico do pacu Histology and ultrastructure of kidney and cephalic kidney in Pacu

    OpenAIRE

    Gerlane M. Costa; Ana R de Lima; Mendelson G. de Lima; José R. Kfoury Jr

    2012-01-01

    O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de...

  12. Bone tumor

    Science.gov (United States)

    Tumor - bone; Bone cancer; Primary bone tumor; Secondary bone tumor ... The cause of bone tumors is unknown. They often occur in areas of the bone that grow rapidly. Possible causes include: Genetic defects passed down ...

  13. Does rim microstructure formation degrade the fuel rod performance?

    International Nuclear Information System (INIS)

    High burnup extension of LWR fuel is progressing to reduce the total process flow and eventually the costs of the nuclear fuel cycle. A particular fuel restructuring at high burnups, commonly observed at the periphery of LWR fuel pellets (rim structure), but also in FBR fuels to some extent and in the Plutonium rich clusters of the MOX Fuels, was considered a priori as a limitation for burnup extension. Since more than ten years this rim effect have been deeply investigated. Its causes and consequences are however not yet totally elucidated. The three steps actually identified of this phenomenon are first a progressive disappearing of the intra-granular Xenon, the outset of numerous 0.5 to 1 m pores and finally a grain subdivision around the pores. Penalty of the porosity increase on the thermal conductivity is obvious. One expect the fission gases to remain trapped in the rim porosity up to a 75 MWd/kgUO2 local burnup. Above this threshold, 15 to 20 % of the fission gases seem to be quickly released. Microindentation tests conducted at ITU have shown the rim structure to resist fracture extension under punching. It is still open whether this implies certain ductility and viscosity of the material, or if it corresponds to stress relaxation by microcracking. Whatever the case be, it is suggested that the rim material would be able to decrease the interaction stresses and to equalise the cladding strains during a power ramp. Moreover, in the RIA tests, it was concluded so far that the grain de-cohesion caused by gas expansion at the grain boundaries was responsible for the cladding strain and failure. However, not the rim zone was affected by grain de-cohesion but the region adjacent to it. Therefore, in front of the question whether the rim structure degrades the fuel rod behaviour, we continue to argue on its benefit for fuel burnup extension. (author)

  14. Parosteal osteoma of the iliac bone

    Energy Technology Data Exchange (ETDEWEB)

    Soler, R.R.; Martinez, S.; Granados, J. [Department of Rheumatology, Hospital Mutua de Terrassa, Barcelona (Spain); de Marcos, J.A. [Department of Radiology, Hospital Mutua de Terrassa, Barcelona (Spain); Salas, A. [Department of Pathology, Hospital Mutua de Terrassa, Barcelona (Spain); Lluc, P. [Primary Care Setting, Sa Canal Salat, Menorca (Spain)

    1998-03-01

    A 33-year-old patient with a 2-year history of intermittent pain in the right gluteal region and thigh presented with a large sclerotic lesion of the iliac bone. From the findings on radiography, scintigraphy, CT and MRI, a giant parosteal osteoma was suspected. The histological examination confirmed the diagnosis. Since the lesion was extensive it was observed with periodic follow-up examinations. At present, 5 years after the diagnosis, the patient is asymptomatic and imaging studies show that the lesion persists with reduction of sclerosis and size. The tumor was on the surface as well as intramedullary - only one other case with such a distribution is known to us - and it was also in the iliac bone. (orig.) With 7 figs., 14 refs.

  15. Aqueous Alteration of Endeavour Crater Rim Apron Rocks

    Science.gov (United States)

    Mittlefehldt, David W.; Ming, Douglas W.; Gellert, Ralf; Clark, Benton C.; Morris, Richard V.; Yen, Albert S.; Arvidson, Raymond E.; Crumpler, Larry S.; Farrand, William H.; Grant, John A.; Jolliff, Bradley L.; Parker, Timothy J.; Peretyazhko, Tanya

    2014-01-01

    Mars Exploration Rover Opportunity is exploring Noachian age rocks of the rim of 22 km diameter Endeavour crater. Overlying the pre-impact lithologies and rim breccias is a thin apron of fine-grained sediments, the Grasberg fm, forming annuli on the lower slopes of rim segments. Hesperian Burns fm sandstones overly the Grasberg fm. Grasberg rocks have major element compositions that are distinct from Burns fm sandstones, especially when comparing interior compositions exposed by the Rock Abrasion Tool. Grasberg rocks are also different from Endeavour rim breccias, but have general compositional similarities to them. Grasberg sediments are plausibly fine-grained materials derived from the impact breccias. Veins of CaSO4 transect Grasberg fm rocks demonstrating post-formation aqueous alteration. Minor/trace elements show variations consistent with mobilization by aqueous fluids. Grasberg fm rocks have low Mn and high Fe/Mn ratios compared to the other lithologies. Manganese likely was mobilized and removed from the Grasberg host rock by redox reactions. We posit that Fe2+ from acidic solutions associated with formation of the Burns sulfate-rich sandstones acted as an electron donor to reduce more oxidized Mn to Mn2+. The Fe contents of Grasberg rocks are slightly higher than in other rocks suggesting precipitation of Fe phases in Grasberg materials. Pancam spectra show that Grasberg rocks have a higher fraction of ferric oxide minerals than other Endeavour rim rocks. Solutions transported Mn2+ into the Endeavour rim materials and oxidized and/or precipitated it in them. Grasberg has higher contents of the mobile elements K, Zn, Cl, and Br compared to the rim materials. Similar enrichments of mobile elements were measured by the Spirit APXS on West Spur and around Home Plate in Gusev crater. Enhancements in these elements are attributed to interactions of hydrothermal acidic fluids with the host rocks. Interactions of fluids with the Grasberg fm postdate the genesis of the Endeavour rim phyllosilicates. The aqueous alteration history of Endeavour rim rocks is complicated by different styles of alteration that have spanned the Noachian and Hesperian. Late stage acidic aqueous alteration of Grasberg fm materials is likely penecontemporaneous with the diagenesis of the sulfate-rich sediments of Meridiani Planum.

  16. Imaging signs and diagnosis of bone echinococcosis

    International Nuclear Information System (INIS)

    Objective: To evaluate the value of imaging investigations in the diagnosis of bone echinococcosis by analysing the X-ray, CT and MBI signs. Methods: Imaging data of 7 patients aged from 23 to 56 years ( mean age 39.5 years) with bone echinococcosis were analysed retrospectively. All cases underwent X-ray plain film examination (frontal view and lateral view); 4 cases were examined with CT; 3 cases received MRI scan. Results: The echinococcosis located in skull (1 case), vertebrae (3 cases), sacrum (1 case), ilium(1 case )and ribs (1 case) respectively. X-ray signs: 5 cases appeared as expanding destructive lesion, two of them were solitary cystic lesions, the others were multiple cystic lesions. Lyric destruction was showed in 2 cases. Sclerotic margin, calcification, soft tissue mass was visible in 5, 1 and 4 cases respectively. CT signs: 3 of 4 cases were expanding destructive lesions, including 2 multiple cystic lesions and 1 solitary cystic destruction. The other one showed lytic destruction. 3 had sclerotic margin; calcification was identified in 2 cases, 4 cases accompanied with soft tissue mass. MRI signs: All of 3 cases occurred at vertebrae, solitary cystic lesion in one and multiple cystic lesions in two. Lesions showed low signal on T1WI image, high signal on T2WI image and appeared as grape shapes. Involved vertebrae showed wedge-shaped. Conclusion: Imaging modalities were significantly valuable in the diagnosis of bone echinococcosis. Combination of X-ray radiography, CT, MRI and epidemiological information is helpful in the diagnosis and differential diagnosis of the bone echinococcosis. (authors)

  17. Pacific Rim coal trade model for U.S. involvement

    International Nuclear Information System (INIS)

    The world contains 700 billion tons of coal reserves mineable by today's technical standards with the United States having one-third of the total. Coal demand of the Pacific Rim will grow very rapidly in the next decade due to expanded use of coal to produce electricity and steel. Imported 1989 coal supply to the Pacific Rim was from Australia (50%), Canada (18%), U.S. (13%), South Africa (7%), U.S.S.R. (6%), China (4%) and Indonesia (1%). The U.S. coal price will continue to trend downward due to increasing mine productivity. The world is moving toward a transnational economy. Groups of nations are forming economic ties and cooperation. This paper reports that the U.S. can increase involvement in the Pacific Rim coal markets by offering value-added coal sales transactions and by understanding Orient culture

  18. Formation of the rim structure in high burnup fuel

    International Nuclear Information System (INIS)

    The process of grain subdivision or polygonization in UO2 was studied by using ion irradiation techniques and by investigating the rim structure in high burnup UO2 fuel. Ion irradiation with fission product ions caused first the formation of subgrain boundaries, observed in high resolution transmission electron microscopy, HRTEM. At higher doses, polygonization was completed at a well defined threshold. High burnup UO2 fuel showing well developed rim zones was investigated in optical, scanning and transmission electron microscopy. The oxygen potential ? anti G(O2), the hardness H and the fracture toughness KIc of the restructured material and the radial dependence of porosity, grain subdivision, H and KIc were measured. KIc was found to change at smaller radial positions than the other properties, indicating a nucleation process not affecting all properties to the same extent. The emerging picture for the formation of the rim structure in UO2 is discussed. (orig.)

  19. Observations of neutral carbon in the NGC 1977 bright rim

    Science.gov (United States)

    Wootten, A.; Phillips, T. G.; Beichman, C. A.; Frerking, M.

    1982-01-01

    Strong neutral carbon emission at 610 microns (492 GHz) has been detected from a bright-rimmed cloud abutting the H II region NGC 1977. The similarity of velocity and width between (C-13)O and C I lines suggests that both lines originate in the same region. A model for the density and temperature structure of the cloud, based on (C-13)O and (C-12)O observations, has been used to estimate the carbon abundance. The abundances of both C I and (C-13)O increase with depth into the cloud away from the rim. The carbon abundance reaches its peak value nearer the rim than does the (C-13)O abundance. This variation in the relative abundance distributions of CO and C I confirms the importance of photodissociation in the chemistry of molecular clouds, and of the C I line to studies of the interaction of hot stars with clouds.

  20. Experimental study of a TAHGEM detector with mini-rims

    International Nuclear Information System (INIS)

    The gas gain and energy resolution of single and double THGEM detectors (5 cm × 5 cm effective area) with mini-rims (rim less than 10 ?m) were studied. The maximum gain was found to reach 5 × 103 and 2 × 105 for single and double THGEMs respectively, while the energy resolution for 5.9 keV X-rays varied from 18% to 28% for both single and double THGEM detectors of different hole sizes and thicknesses. Different combinations were also investigated of noble gases (argon, neon) mixed with a quantity of other gases (isobutane, methane) at atmospheric pressure. (authors)

  1. Experimental study of THGEM detector with mini-rim

    CERN Document Server

    Zhang, Ai-Wu; Xie, Yu-Guang; Liu, Hong-Bang; An, Zheng-Hua; Wang, Zhi-Gang; Cai, Xiao; Sun, Xi-Lei; Shi, Feng; Fang, Jian; Xue, Zhen; Lu, Qi-Wen; Sun, Li-Jun; Ge, Yong-Shuai; Liu, Ying-Biao; Hu, Tao; Zhou, Li; Lu, Jun-Guang

    2011-01-01

    The gas gain and energy resolution of single and double THGEM detectors (5{\\times}5cm2 effective area) with mini-rims (rim is less than 10{\\mu}m) were studied. The maximum gain can reach 5{\\times}103 and 2{\\times}105 for single and double THGEM respectively, while the energy resolution of 5.9 keV X-ray varied from 18% to 28% for both single and double THGEM detectors of different hole sizes and thicknesses.All the experiments were investigated in mixture of noble gases(argon,neon) and small content of other gases(iso-butane,methane) at atmospheric pressure.

  2. Performance of Non-Cemented, Hemispherical, Rim-Fit, Hydroxyapatite Coated Acetabular Component.

    Science.gov (United States)

    John, Thomas K; Ghosh, Gaurav; Ranawat, Chitranjan S; Ranawat, Amar S; Meftah, Morteza

    2015-12-01

    The purpose of this study was to assess the durability of a non-cemented, hemispherical rim-fit, hydroxyapatite coated cup with a highly cross-linked polyethylene in 223 total hip arthroplasties. At 6-years follow-up (range, 5-9), there were no cup revisions for osteolysis or loosening. Radiologic evidence of osseointegration was based on presence of Stress Induced Reactive Cancellous Bone and radial trabeculae, seen in 47% and 93% of cups, respectively; both were most prevalent in Zone 1. There was no interference demarcation in any zones. Two cups were revised (0.9%): one for dislocation and another for infection. The Kaplan-Meier survivorship for cup revision for any failure (infection, dislocation) was 99% and for mechanical failure (osteolysis, loosening) was 100%. This design has excellent safety, efficacy and durability. PMID:26235521

  3. Effect of Er,Cr:YSGG Laser at Different Output Powers on the Micromorphology and the Bond Property of Non-Carious Sclerotic Dentin to Resin Composites

    Science.gov (United States)

    Wang, Weiguo; Jiao, Yang; Wang, Wanshan; Yang, Yanwei; Wei, Jingjing; Shen, Lijuan; Chen, Jihua

    2015-01-01

    Background The objective of this study was to investigate the influence of Er,Cr:YSGG laser irradiated at different powers on the micromorphology and the bonding property of non-carious sclerotic dentin to resin composites. Methods Two hundred bovine incisors characterized by non-carious sclerotic dentin were selected, and the seventy-two teeth of which for surface morphological analysis were divided into nine groups according to various treatments (A: the control group, B: only treated with the adhesive Adper Easy One, C: diamond bur polishing followed by Adper Easy One, D-I: Er,Cr:YSGG laser irradiating at 1W, 2W, 3W, 4W, 5W, 6W output power, respectively, followed by Adper Easy One). The surface roughness values were measured by the non-contact three-dimensional morphology scanner, then the surface micromorphologies of surfaces in all groups were assessed by scanning electron microscopy (SEM); meanwhile, Image Pro-Plus 6.0 software was used to measure the relative percentage of open tubules on SEM images. The rest, one hundred twenty-eight teeth for bond strength test, were divided into eight groups according to the different treatments (A: only treated with the adhesive Adper Easy One, B: diamond bur polishing followed by the above adhesive, C-H: Er,Cr:YSGG laser irradiating at 1 W, 2 W, 3 W, 4 W, 5 W, 6 W output power, respectively, followed by the above adhesive), and each group was subsequently divided into two subgroups according to whether aging is performed (immediately tested and after thermocycling). Micro-shear bond strength test was used to evaluate the bond strength. Results The 4W laser group showed the highest roughness value (30.84±1.93?m), which was statistically higher than the control group and the diamond bur groups (pdentin and resin composites by increasing the roughness and mean percentage area of open tubules. PMID:26544034

  4. Origin of strongly reversed rims on plagioclase in cumulates

    Science.gov (United States)

    Morse, S. A.; Nolan, Kathleen M.

    1984-06-01

    Narrow reversed rims on plagioclase are ubiquitous in troctolites and olivine gabbros of the Kiglapait intrusion and may be a common feature of all such cumulates. The rims occur at plag/plag, plag/ol, and less strongly at plag/aug grain boundaries. They are optically obvious at ?An 30 can easily be achieved by such a process. It is also probable that the trapped liquid is part of an An-rich boundary layer generated by solute rejection during adcumulus growth. The ability of the rims to sustain steep K/Na gradients despite a long subsolidus cooling history proves that the K sbnd Na exchange rate is vanishingly small over a geologic time scale in An-rich feldspar, suggesting that at low K content the potassium is site-bound to the tetrahedral Al/Si distribution. Reversed rims therefore provide important information on diffusion limits as well as on the late-stage solidification history of plagioclase-rich cumulates. Moreover, they demonstrate that plagioclase geothermometry cannot be divorced from effects of liquid composition and structure as monitored, for example, by augite content.

  5. Ultrasensitive analysis of thorium by resonance ionization mass spectroscopy (RIMS)

    International Nuclear Information System (INIS)

    This communication presents results on a RIMS analysis of thorium. Thorium is of interest for geochronological and geochemical purposes. The measurement of uranium series disequilibrium is a well established and valuable approach for geochronological studies: disequilibrium between 234/238U and 230Th can be used to date samples younger than 350,000 years. Both continuous wave (cw) and pulsed lasers were utilized in this study for resonantly exciting and subsequently ionizing thorium. In the case of the pulsed laser RIMS experiments, two excimer laser-pumped dye lasers were used in conjunction with a 0.4 m time-of-flight mass spectrometer. The cw RIMS experiments used an Ar+ laser-pumped dye laser and a second Ar+ in combination with a single magnetic sector mass spectrometer (NBS 12-90 design). Experiments performed with the pulsed RIMS apparatus were aimed at determining the autoionization state structure and re-determining the ionization potential (IP). By tuning one dye laser to a resonance and scanning the second laser such that the total energy was equal to or above the IP, over 150 autoionization states were determined. The IP was re-determined to be 6.211±.002 eV (50900 ± 20 cm-1). In addition, the typical cross section for ionization of an autoionizing state was determined to be 1 x 10-15 cm2

  6. Physiographic rim of the Grand Canyon, Arizona: a digital database

    Science.gov (United States)

    Billingsley, George H.; Hampton, Haydee M.

    1999-01-01

    This Open-File report is a digital physiographic map database. This pamphlet serves to introduce and describe the digital data. There is no paper map included in the Open-File report. The report does include, however, PostScript and PDF format plot files, each containing an image of the map. For those interested in a paper plot of information contained in the database or in obtaining the PostScript plot files, please see the section entitled "For Those Who Don't Use Digital Geologic Map Databases" below. This physiographic map of the Grand Canyon is modified from previous versions by Billingsley and Hendricks (1989), and Billingsley and others (1997). The boundary is drawn approximately along the topographic rim of the Grand Canyon and its tributary canyons between Lees Ferry and Lake Mead (shown in red). Several isolated small mesas, buttes, and plateaus are within this area, which overall encompasses about 2,600 square miles. The Grand Canyon lies within the southwestern part of the Colorado Plateaus of northern Arizona between Lees Ferry, Colorado River Mile 0, and Lake Mead, Colorado River Mile 277. The Colorado River is the corridor for raft trips through the Grand Canyon. Limestone rocks of the Kaibab Formation form most of the north and south rims of the Grand Canyon, and a few volcanic rocks form the north rim of parts of the Uinkaret and Shivwits Plateaus. Limestones of the Redwall Limestone and lower Supai Group form the rim of the Hualapai Plateau area, and Limestones of Devonian and Cambrian age form the boundary rim near the mouth of Grand Canyon at the Lake Mead. The natural physiographic boundary of the Grand Canyon is roughly the area a visitor would first view any part of the Grand Canyon and its tributaries.

  7. A radiographic investigation of third carpal bone injury in 42 racing thoroughbreds

    International Nuclear Information System (INIS)

    A retrospective study of carpal radiographs from 42 racing thoroughbreds with carpal lameness was performed. Radiographs from 50 carpal examinations were available for review. The radiographic findings pertaining to the third carpal bone were described. Fractures and/or sclerosis occurred almost exclusively within the radial fossa. The occurrence of sclerosis without fracture in 20 of the 50 carpal examinations was higher than anticipated, occurring in both the right and left third carpal bone with equal frequency. The right third carpal bone was more frequently fractured and more severely affected than the left. The sclerotic changes seen in the radial fossa of the third carpal bone may be stress-induced, possibly preceding more serious changes in the joint such as cartilage damage or gross fracture. Earlier recognition of sclerosis of the third carpal bone may help prevent more serious changes from occurring

  8. Structural Rim Uplift and Ejecta Thickness Measurements of Complex Martian and Lunar Impact Craters

    Science.gov (United States)

    Sturm, S.; Krüger, T.; Kenkmann, T.

    2015-09-01

    We analyzed twelve martian and five lunar complex impact craters regarding their structural rim uplift and ejecta thickness along their final crater rims. Additionally, we reconstructed the transient crater cavity sizes of these craters.

  9. The Rim Trail at Pipe Spring National Monument, Arizona (pisp_trail)

    Data.gov (United States)

    National Park Service, Department of the Interior — This is an Arc/Info coverage consisting of 4 arcs representing The Rim Trail at Pipe Spring National Monument, Arizona. The Rim Trail was collected by a Trimble...

  10. Factors influencing diagnostic yield of CT-guided percutaneous core needle biopsy for bone lesions

    International Nuclear Information System (INIS)

    Aim: To evaluate the factors influencing diagnostic yield of computed tomography (CT)-guided percutaneous core needle biopsy (CNB) for bone lesions. Materials and methods: Between September 2005 and July 2011, 162 consecutive CT-guided CNB procedures were performed in 155 patients. The variables analysed were age, sex, lesion location, lesion type, lesion size, specimen size, biopsy needle gauge, and individual radiologist. The factors influencing diagnostic yield of CT-guided percutaneous CNB for bone lesions were determined by multivariate analysis of variables. Results: The diagnostic yield was 81.5%. Diagnostic yield was 89.9% for lytic bone lesions and 48.5% for sclerotic bone lesions (p < 0.001), and 89.2% for lesions ?3 cm and 73.4% for lesions <3 cm (p = 0.010). The significant factors influencing diagnostic yield of CT-guided percutaneous CNB for bone lesions were lesion type [p < 0.001; odds ratio (OR) for a lytic lesion was approximately 12 times higher than that for a sclerotic lesion; 95% confidence interval (CI): 4.22–34.01], and lesion size (p = 0.012; OR for a lesion size ?3 cm was about five-times higher than that for a lesion size <3 cm; 95% CI: 1.42–16.71). Conclusion: Lesion type and lesion size are determining factors in diagnostic yield. The higher diagnostic yield is correlated with lytic lesion and lesion size ?3 cm

  11. Interesting bone scans - unusual findings

    Energy Technology Data Exchange (ETDEWEB)

    Dobson, M.; Wadhwa, S.S.; Mansberg, R.; Fernandes, V.B. [Wollongong Hospital, Wollongong, NSW (Australia)

    1997-12-01

    A 59-year-old female with carcinoma of the colon and known liver metastatic disease was referred for bone scan to evaluate for bone metastases. Although no bone metastases were found, there was abnormal uptake noted in the liver corresponding to a metastatic calcified lesion. The only other findings were of degenerative disease in the cervical spine, right shoulder and small joints of the hands. A 69-year-old male with carcinoma of the prostate and right side low back pain was referred for bone scan. No focal abnormalities to suggest metastatic disease were identified; findings within the cervical spine, lumber spine and knees were presumed secondary to degenerative disease. Intermittent pain persisted and the patient was referred for a repeat bone scan six months later. Previous scan findings of degenerative disease and no metastatic disease were confirmed; however, closer inspection revealed an enlarged right kidney with significant retention of tracer in the pelvicalyceal system suggesting possible obstruction. A Retrograde pyelogram was performed, and no obvious obstruction demonstrated. As bone scan findings were very suggestive of obstruction, a DTPA scan with lasix was performed showing a dilated right collecting system with no functional obstruction. Given the degree of dilation, it is possible that the patient experiences intermittent PUJ obstruction causing his symptoms. A 33-year-old male with insulin dependent diabetes mellitus and viral arthritis was referred for a bone scan. A three phase revealed increased uptake in the region of the knee and leR proximal tibia. Delayed whole body images revealed multiple focal areas of osteoblastic activity in the leR tibia. Abnormal uptake was also seen in the upper third of the leR femur. The remainder of the skeletal survey was normal. X-ray correlation of the leR tibia and femoral findings was undertaken. Combinating unilateral changes on bone scan and X-ray although very suggestive of sclerotic polyostotic fibrous dysplasia. Three cases with interesting and unusual bone scan findings assisted in further management and treatment of patients

  12. Interesting bone scans - unusual findings

    International Nuclear Information System (INIS)

    A 59-year-old female with carcinoma of the colon and known liver metastatic disease was referred for bone scan to evaluate for bone metastases. Although no bone metastases were found, there was abnormal uptake noted in the liver corresponding to a metastatic calcified lesion. The only other findings were of degenerative disease in the cervical spine, right shoulder and small joints of the hands. A 69-year-old male with carcinoma of the prostate and right side low back pain was referred for bone scan. No focal abnormalities to suggest metastatic disease were identified; findings within the cervical spine, lumber spine and knees were presumed secondary to degenerative disease. Intermittent pain persisted and the patient was referred for a repeat bone scan six months later. Previous scan findings of degenerative disease and no metastatic disease were confirmed; however, closer inspection revealed an enlarged right kidney with significant retention of tracer in the pelvicalyceal system suggesting possible obstruction. A Retrograde pyelogram was performed, and no obvious obstruction demonstrated. As bone scan findings were very suggestive of obstruction, a DTPA scan with lasix was performed showing a dilated right collecting system with no functional obstruction. Given the degree of dilation, it is possible that the patient experiences intermittent PUJ obstruction causing his symptoms. A 33-year-old male with insulin dependent diabetes mellitus and viral arthritis was referred for a bone scan. A three phase revealed increased uptake in the region of the knee and leR proximal tibia. Delayed whole body images revealed multiple focal areas of osteoblastic activity in the leR tibia. Abnormal uptake was also seen in the upper third of the leR femur. The remainder of the skeletal survey was normal. X-ray correlation of the leR tibia and femoral findings was undertaken. Combinating unilateral changes on bone scan and X-ray although very suggestive of sclerotic polyostotic fibrous dysplasia. Three cases with interesting and unusual bone scan findings assisted in further management and treatment of patients

  13. Magnetic-Field Amplification in the Thin X-ray Rims of SN1006

    OpenAIRE

    Ressler, Sean M.; Katsuda, Satoru; Reynolds, Stephen P.; Knox S. Long; Petre, Robert; Williams, Brian J.; Winkler, P. Frank

    2014-01-01

    Several young supernova remnants (SNRs), including SN1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50 to 100 $\\mu$G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic-field damping could also produce thin rims. Here we review the literature o...

  14. Near-IR Imaging Polarimetry toward a Bright-Rimmed Cloud: Magnetic Field in SFO 74

    OpenAIRE

    Kusune, Takayoshi; Sugitani, Koji; Miao, Jingqi; Tamura, Motohide; Sato, Yaeko; Kwon, Jungmi; Watanabe,Makoto; Nishiyama, Shogo; Nagayama, Takahiro; Sato, Shuji

    2014-01-01

    We have made near-infrared (JHKs) imaging polarimetry of a bright-rimmed cloud (SFO 74). The polarization vector maps clearly show that the magnetic field in the layer just behind the bright rim is running along the rim, quite different from its ambient magnetic field. The direction of the magnetic field just behind the tip rim is almost perpendicular to that of the incident UV radiation, and the magnetic field configuration appears to be symmetric as a whole with respect to...

  15. Energy Dependence of Synchrotron X-Ray Rims in Tycho's Supernova Remnant

    Science.gov (United States)

    Tran, Aaron; Williams, Brian J.; Petre, Robert; Ressler, Sean M.; Reynolds, Stephen P.

    2015-10-01

    Several young supernova remnants (SNRs) exhibit thin X-ray bright rims of synchrotron radiation at their forward shocks. Thin rims require strong magnetic field amplification beyond simple shock compression if rim widths are only limited by electron energy losses. But, magnetic field damping behind the shock could produce similarly thin rims with less extreme field amplification. Variation of rim width with energy may thus discriminate between competing influences on rim widths. We measured rim widths around Tycho's SNR in five energy bands using an archival 750 ks Chandra observation. Rims narrow with increasing energy and are well described by either loss-limited or damped scenarios, so X-ray rim width-energy dependence does not uniquely specify a model. But, radio counterparts to thin rims are not loss-limited and better reflect magnetic field structure. Joint radio and X-ray modeling favors magnetic damping in Tycho's SNR with damping lengths ˜1%-5% of remnant radius and magnetic field strengths ˜50-400 ?G assuming Bohm diffusion. X-ray rim widths are ˜1% of remnant radius, somewhat smaller than inferred damping lengths. Electron energy losses are important in all models of X-ray rims, suggesting that the distinction between loss-limited and damped models is blurred in soft X-rays. All loss-limited and damping models require magnetic fields ?20 ?G, affirming the necessity of magnetic field amplification beyond simple compression.

  16. Stability Analysis of Non-Newtonian Rimming Flow

    CERN Document Server

    Fomin, Sergei; Haine, Peter

    2015-01-01

    The rimming flow of a viscoelastic thin film inside a rotating horizontal cylinder is studied theoretically. Attention is given to the onset of non-Newtonian free-surface instability in creeping flow. This non-inertial instability has been observed in experiments, but current theoretical models of Newtonian fluids can neither describe its origin nor explain its onset. This study examines two models of non Newtonian fluids to see if the experimentally observed instability can be predicted analytically. The non-Newtonian viscosity and elastic properties of the fluid are described by the Generalized Newtonian Fluid (GNF) and Second Order Viscoelastic Fluid (SOVF) constitutive models, respectively. With linear stability analysis, it is found that, analogously to the Newtonian fluid, rimming flow of viscous non-Newtonian fluids (modeled by GNF) is neutrally stable. However, the viscoelastic properties of the fluid (modeled by SOVF) are found to contribute to the flow destabilization. The instability is shown to in...

  17. Radiography, Bone Scan, and F-18 FDG PET/CT Imaging Findings in a Patient with Paget's Disease

    International Nuclear Information System (INIS)

    Background A 52-year-old female patient sought evaluation at our hospital for an incidental abnormal finding on an abdominal radiograph. The initial radiograph showed irregular sclerotic changes involving the right pelvic bone. At the same time, bone scintigraphy showed intense hot uptake in the right iliac and pubic bones. CT images showed characteristic thickening of the pelvic brim, suggesting the mixed phase of Paget's disease. The level of alkaline phosphatase (ALP) was 266 IU/I. 18F-FDG PET/CT images also showed diffusely increased 18F-FDG uptake in the right pelvic bone. However, the findings of 18F-FDG PET/CT were less notable than those of bone scintigraphy. We report the imaging findings of a patient with Paget's disease evaluated by radiography, bone scintigraphy, and 18F-FDG PET/CT.

  18. Selective Isotope Determination of Uranium using HR-RIMS

    International Nuclear Information System (INIS)

    The detection of lowest abundances of the ultra trace isotope 236U in environmental samples requires an efficient detection method which allows a high elemental and isotopic selectivity to suppress neighbouring isotopes of the same element and other background. High Resolution Laser Resonance Ionization Mass Spectrometry (HR-RIMS) uses the individual electron structure of each isotope to provide an outstanding element and isotope selective ionization.

  19. A SCUBA survey of bright-rimmed clouds

    OpenAIRE

    Morgan, L.K.; Thompson, M. A.; Urquhart, J. S.; White, G. J.

    2007-01-01

    Context. Bright-rimmed clouds (BRCs) are potential examples of triggered star formation regions, in which photoionisation driven shocks caused by the expansion of HII regions induce protostellar collapse within the clouds. Aims.The main purpose of the paper is to establish the level of star formation occuring within a known set of BRCs. A secondary aim is to determine the extent, if any, to which this star formation has been promulgated by the process of photoionisation triggering. ...

  20. Compactly supported solutions for a rimming flow model

    International Nuclear Information System (INIS)

    We study a generally ill-posed Cauchy problem with 2?-periodic initial data for a nonlinear forward–backward heat equation. The problem is originated from a lubrication approximation of viscous rimming flow dynamics on the inner surface of a rotating horizontal cylinder in the presence of gravitational field. For a certain class of compactly supported initial data we prove local in time existence of generalized weak solutions. (paper)

  1. Ultrasonic Resonance Spectroscopy of Composite Rims for Flywheel Rotors

    Science.gov (United States)

    Harmon, Laura M.; Baaklini, George Y.

    2002-01-01

    Flywheel energy storage devices comprising multilayered composite rotor systems are being studied extensively for utilization in the International Space Station. These composite material systems were investigated with a recently developed ultrasonic resonance spectroscopy technique. The ultrasonic system employs a continuous swept-sine waveform and performs a fast Fourier transform (FFT) on the frequency response spectrum. In addition, the system is capable of equalizing the amount of energy at each frequency. Equalization of the frequency spectrum, along with interpretation of the second FFT, aids in the evaluation of the fundamental frequency. The frequency responses from multilayered material samples, with and without known defects, were analyzed to assess the capabilities and limitations of this nondestructive evaluation technique for material characterization and defect detection. Amplitude and frequency changes were studied from ultrasonic responses of thick composite rings and a multiring composite rim. A composite ring varying in thickness was evaluated to investigate the full thickness resonance. The frequency response characteristics from naturally occurring voids in a composite ring were investigated. Ultrasonic responses were compared from regions with and without machined voids in a composite ring and a multiring composite rim. Finally, ultrasonic responses from the multiring composite rim were compared before and after proof spin testing to 63,000 rpm.

  2. Hydrogeology associated to faulting of the Chicxulub Impact Crater rim

    Science.gov (United States)

    Rebolledo-Vieyra, M.; Hernandez-Terrones, L.; Almazan-Becerril, A.; Valadez-Cruz, F.

    2011-12-01

    The only surface expression of the Chicxulub Impact Crater is a Ring of Cenotes (sinkholes) whose density varies from several cenotes per kilometer, to several kilometers between each cenote. This ring has a radius of approximately 90 km and it is centered at Chicxulub Puerto. It is not known today whether the Ring of Cenotes is the surface expression of the transient cavity as some authors have suggested, or whether it is the outer rim of the impact structure. The center of the ring is approximately coincident with the center of the Chicxulub Impact Crater. Reactivation of K/T rim faults had been associated to the formation of the ring of cenotes. However, none of these models project such faults to the Tertiary sedimentary sequence; therefore we can only infer that the cenotes are associated to these faults. Other hypotheses include "post impact subsidence induced by slumping and viscous relaxation in the rim" and "slumping in the rim of the buried crater, differential thickness in the rocks overlying the crater, or solution collapse within porous impact deposits", others suggest duration of subaerial exposure and weathering as a principal reason both for difference in permeability and cenote density inside and outside the Ring. This is consistent with the evolution of surface features reported. While sedimentation occurred in the basin outlined by the Ring, erosion and karst weathering were taking place outside the Ring. The karst features are associated with gravity gradients, which have been interpreted as corresponding to peripheral faults of the buried crater. We conducted geoelectric tomography perpendicular to the ring of cenotes, where we mapped the karstic features in the area and we interpret the high permeability in this area, to be associated to the faults generated by the differential compaction of the sedimentary sequence within the crater. This fault system generates a secondary porosity with high permeability that allows the circulation of water, which, in turn, will dissolve the carbonates of the roof and hanging walls of the faults. Another group of cenotes, that is not related to the ring of cenotes, is the alignment of >100 km long chains of elongated solution depressions locally known as sabanas along the Holbox fracture zone-Xel-Ha zone; these alignments support the hypothesis of generation of karst features associated to weakness zones in major fractures zones, such as Holbox fracture zone-Xel-Ha zone and the Chicxulub crater rim.

  3. Estimation of pore pressure in the rim region of high burnup UO2 fuel

    International Nuclear Information System (INIS)

    An attempt has been made to estimate the pore pressure in the rim region of high burnup UO2 fuel as a function of rim burnup using the measured rim width, average porosity and pore density in the rim region. First, a linear relationship is developed based on measured rim burnup and rim width. Second, fraction of fission gas retained in the grain boundary of rim region is estimated. Third, total pores in the rim is calculated from the measured pore density in the rim region. Finally using the assumption that all the pores in the rim have the same size of 1.2μm, pore pressure is calculated from the equation of state for ideal gas. An estimated pore pressure of about 60 to 80 MPa for the rim burnup of 90 GWd/tU appears to be in reasonable agreement with other value given in a literature that pore pressure at 800 K become 90-210 MPa for pellet average burnup of 80 GWd/tU

  4. The management of helical rim keloids with excision, split thickness skin graft and intralesional triamcinolone acetonide

    Directory of Open Access Journals (Sweden)

    Ibrahim Abdul Rasheed

    2014-01-01

    Full Text Available Keloids of the helical rim are disfiguring. A cosmetically acceptable reconstruction is difficult especially in moderate to large sized lesions because the helical rim is a 3-dimensional structure with curved and thin cartilage. We report our experience in the management of moderate (4-10 cm and large (>10 cm helical rim keloids in five patients. Six helical rim keloids were reconstructed. There were four moderate (4-10 cm and two large (>10 cm helical rim keloids. Four were on the right helix and two on the left helix. One patient had bilateral helical rim keloids. The follow-up period ranged from 6 months to 4 years. No secondary surgical revision was required to improve the contour of the reconstructed helical rim. The aesthetic results were satisfactory in all the patients.

  5. Evolution of the east rim of the Hellas basin, Mars

    Science.gov (United States)

    Crown, David A.; Price, Katherine H.; Greeley, Ronald

    1991-01-01

    The Hellas basin is a dominant feature in the ancient, southern cratered highlands of Mars. The east rim of Hellas is a complex geologic region affected by volcanism, tectonism, and channeling. A detailed study of the area between 27.5-42.4 degrees S and 260-275 degrees W was initiated to analyze the processes forming surface materials and to decipher the evolution of this geologically important highland area. Major units include Hadriaca and Tyrrhena Paterae in the north and Hesperian and Amazonian channeled plains and outflow channels in the south. A brief discussion of the findings is presented.

  6. Investigation about crack propagation paths in thin rim gears

    Directory of Open Access Journals (Sweden)

    F. Curà

    2014-10-01

    Full Text Available Crack propagation in gears is a problem related not only to the life of the components, but also to the concept of failsafe design. Fail safe design means to design a component in order that, if a failure occurs, this may cause a “safe failure”. This aspect is very important above all in aerospace industry. As a matter of fact, in aerospace application, the need of reducing weight brings to produce gears with very thick rim and web. Considering thin rim gears, when a crack is nucleated near the tooth root, it may propagate through the tooth (causing the loss of the entire tooth or a portion of it or the propagation may follow a path across the wheel diameter (causing the projection of big parts of the gear that may break the gearbox and may cause serious damage to the aircraft. The first failure mode is define as “failsafe failure” and the second one as “catastrophic failure” and of course has to be avoided. Designers need to have robust design criteria in order to predict crack propagation paths and to avoid catastrophic failures. In literature, few works are present concerning this topic, in particular related to the effect of geometrical parameters that may affect the crack propagation. In this work a numerical analysis about crack propagation in gears with respect to the backup ratio (ratio between tooth height and rim thickness, initial crack position and shape has been done by means of the Extended FEM (XFEM technique, realizing 3D models. XFEM 3D is a relatively new technique consisting in enriching traditional finite elements with more complex shape functions; in this way it is possible to propagate crack also between mesh nodes and to have mesh independent results. Aim of this paper is to highlight the crack propagation path in order to give to designers an high confident design criterion, related to the gear geometry. In particular, the effect of both rim thickness and orientation of the initial crack have been considered in order to enrich the literature knowledge. Numerical results obtained in this work have been compared with those found in the literature, showing a very good correlation.

  7. Triggered Star Formation in the Orion Bright-Rimmed Clouds

    OpenAIRE

    Lee, Hsu-Tai; Chen, W. P.; Zhang, Zhi-Wei; Hu, Jing-Yao

    2005-01-01

    We have developed an empirical and effective set of criteria, based on the 2MASS colors, to select candidate classical T Tauri stars (CTTS). This provides a useful tool to study the young stellar population in star-forming regions. Here we present our analysis of the bright-rimmed clouds (BRCs) B 35, B 30, IC 2118, LDN 1616, LDN 1634, and Orion East to show how massive stars interact with molecular clouds to trigger star formation. Our results support the radiation-driven im...

  8. A STUDY OF HAEMOGLOBIN PATTERNS AMONG THE STUDENTS OF RIMS

    Directory of Open Access Journals (Sweden)

    Urmila

    2015-11-01

    Full Text Available Haemoglobinopathies are a major health problem worldwide. Because of the high prevalence of these disorders in India and especially in North–East, we undertook this limited student based study as RIMS comprised students from the seven North-East states of Arunachal Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Sikkim and Tripura. AIMS: To study the prevalence of haemoglobin variants among the North-East students of RIMS and to find out any abnormal haemoglobin pattern pertaining to a particular community. MATERIAL AND METHODS: The present study was carried out in the Department of Pathology, RIMS. From Sept. 2002 to Dec. 2004, our study included 100 student volunteers taking a minimum of ten from each of the seven states. History of presenting complaints, personal, family and past illness were taken. Physical examination was done with special emphasis on appearance, presence of pallor, jaundice and hepatosplenomegaly etc. Blood samples were collected in 2 EDTA vials, one was used for CBC and another for preparation of hemolysate. CBC was done for all cases by electronic cell counter supported by manual hemocytometry, peripheral blood examination and reticulocyte count. All the cases were routinely screened for haemoglobin type using standard alkaline cellulose acetate electrophoresis with Tris-Ethylene Diamine Tetra Acetic Acid (EDTA borate buffer. Fetal Hb. estimation, sickling test, serum bilirubin estimation were also done in relevant cases. RESULTS: Out of the 100 student volunteers studied, 98 cases showed HbA pattern in 46 males and 52 females while HbE was seen in 2 cases, 1 male and a female. The prevalence of HbE was 2% in our study, which belonged to the ethnic group of Garo of Meghalaya. Both case had mild anemia with microcytosis and normal reticulocyte count. Peripheral smear showed anisopoikilocytosis and target cells. RBC count, MCH values were within normal range. CONCLUSION: Our study showed that HbA was the predominant haemoglobin type amongst the North-East students of RIMS. HbE was also prevalent amongst these students and common among the mongoloid group of Garo with an incidence of 2%. As this study is limited student volunteer based, it cannot represent any community/population. It emphasises the need for further studies with a larger sample involving many communities of different ethnic groups to support the above findings before drawing a conclusion.

  9. Energy Dependence of Synchrotron X-Ray Rims in Tycho's Supernova Remnant

    CERN Document Server

    Tran, Aaron; Petre, Robert; Ressler, Sean M; Reynolds, Stephen P

    2015-01-01

    Several young supernova remnants exhibit thin X-ray bright rims of synchrotron radiation at their forward shocks. Thin rims require strong magnetic field amplification beyond simple shock compression if rim widths are only limited by electron energy losses. But, magnetic field damping behind the shock could produce similarly thin rims with less extreme field amplification. Variation of rim width with energy may thus discriminate between competing influences on rim widths. We measured rim widths around Tycho's supernova remnant in 5 energy bands using an archival 750 ks Chandra observation. Rims narrow with increasing energy and are well described by either loss-limited or damped scenarios, so X-ray rim width-energy dependence does not uniquely specify a model. But, radio counterparts to thin rims are not loss-limited and better reflect magnetic field structure. Joint radio and X-ray modeling favors magnetic damping in Tycho's SNR with damping lengths ~1--5% of remnant radius and magnetic field strengths ~50--...

  10. NEAR-IR IMAGING POLARIMETRY TOWARD A BRIGHT-RIMMED CLOUD: MAGNETIC FIELD IN SFO 74

    Energy Technology Data Exchange (ETDEWEB)

    Kusune, Takayoshi; Sugitani, Koji [Graduate School of Natural Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-8501 (Japan); Miao, Jingqi [Centre for Astrophysics and Planetary Science, School of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NR (United Kingdom); Tamura, Motohide; Kwon, Jungmi [Department of Astronomy, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Sato, Yaeko [National Astronomical Observatory, 2-21-1 Osawa, Mikata, Tokyo 181-8588 (Japan); Watanabe, Makoto [Department of Cosmosciences, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0810 (Japan); Nishiyama, Shogo [Faculty of Education, Miyagi University of Education, Sendai 980-0845 (Japan); Nagayama, Takahiro [Department of Physics, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065 (Japan); Sato, Shuji [Department of Astrophysics, Nagoya University, Chikusa-ku, Nagoya 464-8602 (Japan)

    2015-01-01

    We have made near-infrared (JHK {sub s}) imaging polarimetry of a bright-rimmed cloud (SFO 74). The polarization vector maps clearly show that the magnetic field in the layer just behind the bright rim is running along the rim, quite different from its ambient magnetic field. The direction of the magnetic field just behind the tip rim is almost perpendicular to that of the incident UV radiation, and the magnetic field configuration appears to be symmetric as a whole with respect to the cloud symmetry axis. We estimated the column and number densities in the two regions (just inside and far inside the tip rim) and then derived the magnetic field strength, applying the Chandrasekhar-Fermi method. The estimated magnetic field strength just inside the tip rim, ?90 ?G, is stronger than that far inside, ?30 ?G. This suggests that the magnetic field strength just inside the tip rim is enhanced by the UV-radiation-induced shock. The shock increases the density within the top layer around the tip and thus increases the strength of the magnetic field. The magnetic pressure seems to be comparable to the turbulent one just inside the tip rim, implying a significant contribution of the magnetic field to the total internal pressure. The mass-to-flux ratio was estimated to be close to the critical value just inside the tip rim. We speculate that the flat-topped bright rim of SFO 74 could be formed by the magnetic field effect.

  11. NEAR-IR IMAGING POLARIMETRY TOWARD A BRIGHT-RIMMED CLOUD: MAGNETIC FIELD IN SFO 74

    International Nuclear Information System (INIS)

    We have made near-infrared (JHK s) imaging polarimetry of a bright-rimmed cloud (SFO 74). The polarization vector maps clearly show that the magnetic field in the layer just behind the bright rim is running along the rim, quite different from its ambient magnetic field. The direction of the magnetic field just behind the tip rim is almost perpendicular to that of the incident UV radiation, and the magnetic field configuration appears to be symmetric as a whole with respect to the cloud symmetry axis. We estimated the column and number densities in the two regions (just inside and far inside the tip rim) and then derived the magnetic field strength, applying the Chandrasekhar-Fermi method. The estimated magnetic field strength just inside the tip rim, ?90 ?G, is stronger than that far inside, ?30 ?G. This suggests that the magnetic field strength just inside the tip rim is enhanced by the UV-radiation-induced shock. The shock increases the density within the top layer around the tip and thus increases the strength of the magnetic field. The magnetic pressure seems to be comparable to the turbulent one just inside the tip rim, implying a significant contribution of the magnetic field to the total internal pressure. The mass-to-flux ratio was estimated to be close to the critical value just inside the tip rim. We speculate that the flat-topped bright rim of SFO 74 could be formed by the magnetic field effect

  12. Catecholamines and related o-diphenols in cockroach hemolymph and cuticle during sclerotization and melanization: comparative studies on the order Dictyoptera.

    Science.gov (United States)

    Czapla, T H; Hopkins, T L; Kramer, K J

    1990-01-01

    Catecholamines and related o-diphenols extracted from the cuticle and hemolymph of adult cockroaches during sclerotization and pigmentation of the cuticle were analyzed by reverse phase HPLC with electrochemical detection. At ecdysis, dopamine (DA) o-conjugates predominated in the hemolymph of Periplaneta americana, P. australasiae, P. fuliginosa, P. brunnea, and Blatta orientalis (Blattidae); Blattella germanica (Blattellidae); and Gromphadorhina portentosa and Blaberus craniifer (Blaberidae). N-Acetyldopamine (NADA) conjugates were second in abundance in these species, but were major in the hemolymph of the other blaberoid species, Leucophaea maderae and Nauphoeta cinerea. After ecdysis NADA became the major hemolymph catecholamine in all species as DA decreased rapidly. N-beta-Alanyldopamine (NBAD) concentrations in the hemolymph remained low in all species, although NBAD and its metabolite, N-beta-alanylnorepinephrine (NBANE), were generally the major catecholamines in tanning cuticle. Catechol (1,2-dihydroxybenzene) occurred mainly as a conjugate(s) at high levels in the hemolymph of nymphs and adults of all blattid species. Only trace amounts were detected in B. germanica and Cryptocercus punctulatus (Cryptocercidae), and none was found in any of the blaberoid species. High concentrations of NBANE and NBAD accumulated in tanning cuticle of B. germanica, G. portentosa, and all blattid species, whereas NADA and DA predominated in cuticle from the other blaberoid species, particularly L. maderae and N. cinerea. However, cockroaches as a group appear to utilize both the N-acetyl and N-beta-alanyl catecholamines for stabilization of the exoskeleton. The Blattidae differed most from the other families in having considerably higher concentrations of catecholamines in hemolymph and cuticle, as well as the large amounts of catechol conjugates in the hemolymph. PMID:2391402

  13. Bone Cancer

    Science.gov (United States)

    Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another ... more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and ...

  14. The importance of rim removal in deep lateral orbital wall decompression

    Directory of Open Access Journals (Sweden)

    Kakizaki H

    2011-06-01

    Full Text Available Hirohiko Kakizaki1, Yasuhiro Takahashi1, Akihiro Ichinose2, Masayoshi Iwaki1, Dinesh Selva3, Igal Leibovitch41Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi, Japan; 2Department of Plastic Surgery, Kobe University, Kobe, Hyogo, Japan; 3South Australian Institute of Ophthalmology and Discipline of Ophthalmology and Visual Sciences, University of Adelaide, South Australia, Australia; 4Division of Oculoplastic and Orbital Surgery, Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, IsraelPurpose: To evaluate the surgical outcome of deep lateral orbital decompression with or without rim removal.Design: Retrospective case series.Methods: Thirty-two patients (47 orbits with Graves’ orbitopathy who underwent simple deep lateral decompression or balanced lateral plus medial decompression. Of the 14 patients (24 orbits who underwent simple deep lateral decompression, 8 (13 orbits had temporary rim removal and in 6 (11 orbits the rim was left intact. Of the 18 patients (23 orbits who underwent a balanced decompression, 7 (9 orbits had temporary rim removal and in 11 (14 orbits the rim was left intact. The amount of postoperative reduction in proptosis was compared among these four groups.Results: The average reduction in proptosis in the simple deep lateral decompression group was 5.73 mm (range: 4.0–8.0 mm in the rim removal group and 4.09 mm (range: 2.5–6.0 mm in the intact rim group (P = 0.005. The average reduction in proptosis in the balanced decompression group was 6.39 mm (range: 5.0–8.5 mm in the rim removal group and 5.07 mm (range: 3.0–8.0 mm in the intact rim group (P = 0.039. There was no statistically significant difference in proptosis reduction between the simple deep lateral decompression with rim removal group and the balanced decompression with an intact rim group (P = 0.220.Conclusion: The rim removal approach allows a more effective decompression than the intact rim approach. Simple deep lateral decompression with rim removal approach has a similar effect to balanced decompression through an intact rim.Keywords: deep lateral decompression, balanced decompression, rim removal, intact rim, Graves’ orbitopathy, proptosis

  15. Dam and spillway construction to remediate a failed reservoir rim

    Energy Technology Data Exchange (ETDEWEB)

    Kostaschuk, R.; Grover, P.; Wanner, C. [AMEC Earth and Environmental Ltd., Calgary, AB (Canada); Lockhart, S. [Priddis Greens Golf and Country Club, Priddis, AB (Canada)

    2009-07-01

    Priddis Greens Golf and Country Club (PGGCC) is located in southern Alberta, about 25 kilometres southwest of Calgary. Lake Loon reservoir supplies water for irrigation of the 36-hole golf course and also supplies water to the water treatment plant that provides potable water to the golf course and the housing development. An earthen spillway channel on the reservoir rim failed by erosion at the PGGCC during an extreme flood event in June 2005. The failure resulted in loss of the reservoir for the water supply system servicing the golf course and its housing cooperative. Design and reconstruction of the reservoir rim were undertaken and a new concrete spillway structure was built. This paper provided background information on the June 2005 failure and provided an overview of the design concept for reservoir restoration. The Alberta Environment permitting process was also outlined. Hydrology, flood management and spillway design were explained in detail. A geotechnical design of earthworks was also provided. The paper concluded with a discussion of an emergency preparedness and response plan and operation, maintenance and surveillance manual that were developed for the project. 2 refs., 20 figs.

  16. Dark-rimmed Crater and Extensive Ejecta Blanket

    Science.gov (United States)

    1974-01-01

    Mariner 10 took this picture (FDS 166840) from a distance of 63,400 kilometers (39,300 miles) about an hour after it passed under the South Pole of Mercury. The dark-rimmed crater at upper left is 67 kilometers (42 miles) in diameter. It is surrounded by an extensive ejecta blanket and exhibits a bright ray pattern, which extends into and beyond the larger crater (120 kilometers, 75 miles) to its right and near the picture's center. The dark-rimmed crater is similar to crater Tycho on Earth's moon. The center of this picture is located 33 degrees S. Lat. 158 degrees W. Long. North is to the top.The Mariner 10 mission, managed by the Jet Propulsion Laboratory for NASA's Office of Space Science, explored Venus in February 1974 on the way to three encounters with Mercury-in March and September 1974 and in March 1975. The spacecraft took more than 7,000 photos of Mercury, Venus, the Earth and the Moon.Image Credit: NASA/JPL/Northwestern University

  17. Optimization of Hydride Rim Formation in Unirradiated Zr 4 Cladding

    Energy Technology Data Exchange (ETDEWEB)

    Shimskey, Rick W.; Hanson, Brady D.; MacFarlan, Paul J.

    2013-09-30

    The purpose of this work is to build on the results reported in the M2 milestone M2FT 13PN0805051, document number FCRD-USED-2013-000151 (Hanson, 2013). In that work, it was demonstrated that unirradiated samples of zircaloy-4 cladding could be pre-hydrided at temperatures below 400°C in pure hydrogen gas and that the growth of hydrides on the surface could be controlled by changing the surface condition of the samples and form a desired hydride rim on the outside diameter of the cladding. The work performed at Pacific Northwest National Laboratory since the issuing of the M2 milestone has focused its efforts to optimize the formation of a hydride rim on available zircaloy-4 cladding samples by controlling temperature variation and gas flow control during pre-hydriding treatments. Surface conditioning of the outside surface was also examined as a variable. The results of test indicate that much of the variability in the hydride thickness is due to temperature variation occurring in the furnaces as well as how hydrogen gas flows across the sample surface. Efforts to examine other alloys, gas concentrations, and different surface conditioning plan to be pursed in the next FY as more cladding samples become available

  18. Signaling Events of the Rim101 Pathway Occur at the Plasma Membrane in a Ubiquitination-Dependent Manner

    OpenAIRE

    Obara, Keisuke; Kihara, Akio

    2014-01-01

    In yeast, external alkalization and alteration in plasma membrane lipid asymmetry are sensed by the Rim101 pathway. It is currently under debate whether the signal elicited by external alkalization is transduced to downstream molecules at the plasma membrane or via endocytosis of the Rim21 sensor protein at the late endosome. We found that the downstream molecules, including arrestin-related protein Rim8, calpain-like protein Rim13, and scaffold protein Rim20, accumulated at the plasma membra...

  19. Influence of deformation on dolomite rim growth kinetics

    Science.gov (United States)

    Helpa, Vanessa; Rybacki, Erik; Grafulha Morales, Luiz Fernando; Dresen, Georg

    2015-04-01

    Using a gas-deformation apparatus stacks of oriented calcite (CaCO3) and magnesite (MgCO3) single crystals were deformed at T = 750° C and P = 400 MPa to examine the influence of stress and strain on magnesio-calcite and dolomite (CaMg[CO3]2) growth kinetics. Triaxial compression and torsion tests performed at constant stresses between 7 and 38 MPa and test durations between 4 and 171 hours resulted in bulk strains of 0.03-0.2 and maximum shear strains of 0.8-5.6, respectively. The reaction rims consist of fine-grained (2-7 ?m) dolomite with palisade-shaped grains growing into magnesite reactants and equiaxed granular dolomite grains next to calcite. In between dolomite and pure calcite, magnesio-calcite grains evolved with an average grain size of 20-40 ?m. Grain boundaries tend to be straighter at high bulk strains and equilibrium angles at grain triple junctions are common within the magnesio-calcite layer. Transmission electron microscopy shows almost dislocation free palisades and increasing dislocation density within granular dolomite towards the magnesio-calcite boundary. Within magnesio-calcite grains, dislocations are concentrated at grain boundaries. Variation of time at fixed stress (˜17 MPa) yields a parabolic time dependence of dolomite rim width, indicating diffusion-controlled growth, similar to isostatic rim growth behavior. In contrast, the magnesio-calcite layer growth is enhanced compared to isostatic conditions. Triaxial compression at given time shows no significant change of dolomite rim thickness (11±2 ?m) and width of magnesio-calcite layers (33±5 ?m) with increasing stress. In torsion experiments, reaction layer thickness and grain size decrease from the center (low stress/strain) to the edge (high strain/stress) of samples. Chemical analysis shows nearly stoichiometric composition of dolomite palisades, but enhanced Ca content within granular grains, indicating local disequilibrium with magnesio-calcite, in particular for twisted samples. The shift from local equilibrium is ˜3 mol% in triaxial compression and ˜7 mol% in torsion. Electron backscatter diffraction analysis reveals a crystallographic preferred orientation (CPO) within the reaction layers with [0001] axes parallel to the compression/rotation axis and poles of {2-1-10} and {10-10} prismatic planes parallel to the reaction interface. Compared to isostatic annealing, the CPO is more pronounced and the amount of low-angle grain boundaries is increased. At the imposed experimental conditions, most of the bulk deformation is accommodated by calcite single, which is stronger than magnesite. Application of flow laws for magnesio-calcite and dolomite suggest that the fine-grained reaction products should deform by grain boundary diffusion creep, resulting in lower flow strength than the single crystal reactants. However, microstructural observations indicate that deformation of granular dolomite and magnesio-calcite is at least partially assisted by dislocation creep, which would result in an almost similar strength to calcite. Therefore, flattening of the reaction layers during triaxial compression may be counterbalanced by enhanced reaction rates, resulting in almost constant layer thickness, independent of the applied stress. For simple shear, the reduced reaction kinetics in the high stress/strain region of twisted samples may be related to increased nucleation rates, resulting in a lower grain size and rim thickness.

  20. Analysis of the energy capacity of rim-spoke composite flywheels

    International Nuclear Information System (INIS)

    The rim-spoke flywheel consisting of a rim, connected to the hub by spokes encompassing the rim periphery, is one of the most promising types of energy accumulators. For the rational design of rim-spoke flywheels, the authors investigate the dependence of their mass energy capacity and their volume energy capacity; the limit speed on the geometric parameters of the flywheel and the properties of the composites used in making the rim and the spokes are also examined. It is shown through various programs, worked out for analyzing the energy capacity of rim-spoke flywheels, that they can substantially facilitate the designing of such flywheels according to specified requirements that their operational characteristics have to meet

  1. Radiography, Bone Scan, and F-18 FDG PET/CT Imaging Findings in a Patient with Paget's Disease

    Energy Technology Data Exchange (ETDEWEB)

    Park, Eun Tae; Kim, Sung Eun [Korea University Guro Hospital, Seoul (Korea, Republic of)

    2010-04-15

    Background A 52-year-old female patient sought evaluation at our hospital for an incidental abnormal finding on an abdominal radiograph. The initial radiograph showed irregular sclerotic changes involving the right pelvic bone. At the same time, bone scintigraphy showed intense hot uptake in the right iliac and pubic bones. CT images showed characteristic thickening of the pelvic brim, suggesting the mixed phase of Paget's disease. The level of alkaline phosphatase (ALP) was 266 IU/I. {sup 18}F-FDG PET/CT images also showed diffusely increased {sup 18}F-FDG uptake in the right pelvic bone. However, the findings of {sup 18}F-FDG PET/CT were less notable than those of bone scintigraphy. We report the imaging findings of a patient with Paget's disease evaluated by radiography, bone scintigraphy, and {sup 18}F-FDG PET/CT.

  2. A prospective analysis of CT density measurements of bone metastases after treatment with zoledronic acid

    Energy Technology Data Exchange (ETDEWEB)

    Quattrocchi, Carlo C.; Dell' Aia, Paola; Piciucchi, Sara; Grasso, Rosario F.; Zobel, Bruno B. [Centro Interdisciplinare per la Ricerca Bio-Medica, Department of Radiology, Rome (Italy); Santini, Daniele; Vincenzi, Bruno; Tonini, Giuseppe [University Campus Bio-Medico di Roma, Department of Oncology, Rome (Italy); Leoncini, Emanuele [Statistica Sanitaria, University La Sapienza, Rome (Italy)

    2007-12-15

    The objective was to prospectively determine CT density changes in bone metastases, before and after intravenous zoledronic acid for a maximum period of 12 months. Twenty-three consecutive patients presented with bone metastases and underwent therapy with zoledronic acid from December 2004. All patients underwent CT of the chest, abdomen, and pelvis. Bone density, measured in Hounsfield units (HU), was determined by segmenting lesions in the same anatomical area of the metastasis sites on the axial images of the sequential series of CT examinations. The effects of zoledronic acid were evaluated by calculating absolute and relative increases in bone density. The patients presented with multiple metastases in 65% of the cases. When compared with the baseline, all groups demonstrated a significant increase in bone density, which significantly (p < 0.01) correlated with the number of zoledronic acid administrations. There was increased bone density of at least 100% in 57%, and an increase of at least 50% in 87% of the patients. This increase was significant in both lytic and sclerotic metastases after 3 months of therapy. No significant bone density difference was found in normal-appearing bone. Bone density measured by CT increases at metastatic sites after zoledronic acid treatment, regardless of the type of metastasis, in contrast to apparently normal bone. (orig.)

  3. A prospective analysis of CT density measurements of bone metastases after treatment with zoledronic acid

    International Nuclear Information System (INIS)

    The objective was to prospectively determine CT density changes in bone metastases, before and after intravenous zoledronic acid for a maximum period of 12 months. Twenty-three consecutive patients presented with bone metastases and underwent therapy with zoledronic acid from December 2004. All patients underwent CT of the chest, abdomen, and pelvis. Bone density, measured in Hounsfield units (HU), was determined by segmenting lesions in the same anatomical area of the metastasis sites on the axial images of the sequential series of CT examinations. The effects of zoledronic acid were evaluated by calculating absolute and relative increases in bone density. The patients presented with multiple metastases in 65% of the cases. When compared with the baseline, all groups demonstrated a significant increase in bone density, which significantly (p < 0.01) correlated with the number of zoledronic acid administrations. There was increased bone density of at least 100% in 57%, and an increase of at least 50% in 87% of the patients. This increase was significant in both lytic and sclerotic metastases after 3 months of therapy. No significant bone density difference was found in normal-appearing bone. Bone density measured by CT increases at metastatic sites after zoledronic acid treatment, regardless of the type of metastasis, in contrast to apparently normal bone. (orig.)

  4. RIM, Munc13, and Rab3A interplay in acrosomal exocytosis

    International Nuclear Information System (INIS)

    Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: ? RIM and Munc13 are present in human sperm and localize to the acrosomal region. ? RIM and Munc13 are necessary for acrosomal exocytosis. ? RIM and Munc13 participate before the acrosomal calcium efflux. ? RIM, Munc13 and Rab3A interplay in human sperm acrosomal exocytosis. ? RIM and Rab3A have critical roles in membrane docking.

  5. Rimmed Vacuoles in Becker Muscular Dystrophy Have Similar Features with Inclusion Myopathies

    OpenAIRE

    Momma, Kazunari; Noguchi, Satoru; Malicdan, May Christine V.; Hayashi, Yukiko K; Minami, Narihiro; Kamakura, Keiko; NONAKA, Ikuya; NISHINO, Ichizo

    2012-01-01

    Rimmed vacuoles in myofibers are thought to be due to the accumulation of autophagic vacuoles, and can be characteristic in certain myopathies with protein inclusions in myofibers. In this study, we performed a detailed clinical, molecular, and pathological characterization of Becker muscular dystrophy patients who have rimmed vacuoles in muscles. Among 65 Becker muscular dystrophy patients, we identified 12 patients who have rimmed vacuoles and 11 patients who have deletions in exons 45–48 i...

  6. Non-destructive examination technique for steam turbine rotor disk rim cracking

    International Nuclear Information System (INIS)

    Turbine disk rim cracking in thermal and nuclear power plants has been a major reliability issue in recent years. This problem which includes both circumferential and radial direction cracking on the hidden face of rim fixation behind the blade hook has become very important in periodic non-destructive examination. To detect these defects, the UT inspection techniques using a conventional single angle probe and a phased array probe without removing blades from wheel rim are developed. This paper summarizes and discusses non-destructive examination methods for turbine rim cracking using phased array technique and other technique and these results. (author)

  7. Eastern rim of the Chesapeake Bay impact crater: Morphology, stratigraphy, and structure

    Science.gov (United States)

    Poag, C.W.

    2005-01-01

    This study reexamines seven reprocessed (increased vertical exaggeration) seismic reflection profiles that cross the eastern rim of the Chesapeake Bay impact crater. The eastern rim is expressed as an arcuate ridge that borders the crater in a fashion typical of the "raised" rim documented in many well preserved complex impact craters. The inner boundary of the eastern rim (rim wall) is formed by a series of raterfacing, steep scarps, 15-60 m high. In combination, these rim-wall scarps represent the footwalls of a system of crater-encircling normal faults, which are downthrown toward the crater. Outboard of the rim wall are several additional normal-fault blocks, whose bounding faults trend approximately parallel to the rim wall. The tops of the outboard fault blocks form two distinct, parallel, flat or gently sloping, terraces. The innermost terrace (Terrace 1) can be identified on each profile, but Terrace 2 is only sporadically present. The terraced fault blocks are composed mainly of nonmarine, poorly to moderately consolidated, siliciclastic sediments, belonging to the Lower Cretaceous Potomac Formation. Though the ridge-forming geometry of the eastern rim gives the appearance of a raised compressional feature, no compelling evidence of compressive forces is evident in the profiles studied. The structural mode, instead, is that of extension, with the clear dominance of normal faulting as the extensional mechanism. ?? 2005 Geological Society of America.

  8. The status of water and sanitation among Pacific Rim nations.

    Science.gov (United States)

    Arnold, Robert G; Heyworthz, Jane; Sáez, A Eduardo; Rodriguez, Clemencia; Weinstein, Phil; Ling, Bo; Memon, Saima

    2011-01-01

    Analysis of relationships among national wealth, access to improved water supply and sanitation facilities, and population health indices suggests that the adequacy of water resources at the national level is a poor predictor of economic development--namely, that low water stress is neither necessary nor sufficient for economic development at the present state of water stress among Pacific Rim nations. Although nations differ dramatically in terms of priority provided to improved water and sanitation, there is some level of wealth (per capita GNP) at which all nations promote the development of essential environmental services. Among the Pacific Rim countries for which there are data, no nation with a per capita GNP > US$18,000 per year has failed to provide near universal access to improved water supply and sanitation. Below US$18,000/person-year, however, there are decided differences in the provision of sanitary services (improved water supply and sanitation) among nations with similar economic success. There is a fairly strong relationship between child mortality/life expectancy and access to improved sanitation, as expected from the experiences of developed nations. Here no attempt is made to produce causal relationships among these data. Failure to meet Millennium Development Goals for the extension of improved sanitation is frequently evident in nations with large rural populations. Under those circumstances, capital intensive water and sanitation facilities are infeasible, and process selection for water/wastewater treatment requires an adaptation to local conditions, the use of appropriate materials, etc., constraints that are mostly absent in the developed world. Exceptions to these general ideas exist in water-stressed parts of developed countries, where water supplies are frequently augmented by water harvesting, water reclamation/reuse, and the desalination of brackish water resources. Each of these processes involves public acceptance of water resources that are at least initially of inferior quality. Despite predictions of looming increases in water stress throughout the world, adaptation and resourcefulness generally allow us to meet water demand while pursuing rational economic development, even in the most water-stressed areas of the Pacific Rim. PMID:21714378

  9. Mass Movement on Vesta at Steep Scarps and Crater Rims

    Science.gov (United States)

    Krohn, K.; Jaumann, R.; Otto, K.; Hoogenboom, T.; Wagner, R.; Buczkowski, D. L.; Garry, B.; Williams, D. A.; Yingst, R. A.; Scully, J.; De Sanctis, M. C.; Kneissl, T.; Schmedemann, N.; Kersten, E.; Stephan, K.; Matz, K.-D.; Pieters, C. M.; Preusker, F.; Roatsch, T.; Schenk, P.; Russell, C. T.; Raymond, C. A.

    2014-01-01

    The Quadrangles Av-11 and Av-12 on Vesta are located at the northern rim of the giant Rheasilvia south polar impact basin. The primary geologic units in Av-11 and Av-12 include material from the Rheasilvia impact basin formation, smooth material and different types of impact crater structures (such as bimodal craters, dark and bright crater ray material and dark ejecta material). Av-11 and Av-12 exhibit almost the full range of mass wasting features observed on Vesta, such as slump blocks, spur-and-gully morphologies and landslides within craters. Processes of collapse, slope instability and seismically triggered events force material to slump down crater walls or scarps and produce landslides or rotational slump blocks. The spur-and-gully morphology that is known to form on Mars is also observed on Vesta; however, on Vesta this morphology formed under dry conditions.

  10. Unusual Radar Backscatter along the Northern Rim of Imbrium Basin

    Science.gov (United States)

    Thompson, Thomas W.; Campbell, Bruce A.; Ghent, Rebecca R.; Hawke, B. Ray; Leverington, David W.

    2006-01-01

    A viewgraph presentation of the unusual radar backscatter properties along the Northern Rim of Imbrium Basin is shown. The contents include: 1) Visual and Infrared Observations of Moon; 2) Radar Observations of Moon; 3) Lunar Orbiter Photographs Geologic Setting; 4) 70-cm Radar Data; 5) .70-cm Radar Dark Halo Craters; 6) 3.8-cm Radar Data; 7) 7.5-m Radar Data; 8) 70cm, 3.8 cm and 7.5-m Radar Data; 9) Optical and Infrared Data; 10) Plato Rilles; 11) Isopachs of Crater Ejecta; 12) Plato-like Craters; 13) Observation Summary; 14) Interpretation Matrix; 15) Dark Halo Diameters vs. Crater Size; and 16) Radar Geologic Column.

  11. Windage rise and flowpath gas ingestion in turbine rim cavities

    Science.gov (United States)

    Haaser, Fred; Jack, James; McGreehan, William

    1987-05-01

    A method for modeling the windage rise and flowpath gas ingestion in turbine rim cavities on a macroscopic scale is presented, with application to the minimization of the necessary required cooling air in order to provide optimum turbine cycle performance and hardware durability. Comparison is made between measured and predicted results for: (1) the prediction of critical flow in a turbine aeroperformance rig; (2) a boltless blade retainer design; (3) the impact of instrumentation wire; and (4) a modulated throughflow test. It is noted that the effects of inner and outer flow extraction, rotor and stator drag, rotor and stator bolt drag, leakages, and injection momentum must be accounted for to accurately model the wheel space.

  12. [Sialic Acid Replacement Therapy for Distal Myopathy with Rimmed Vacuoles].

    Science.gov (United States)

    Mori-Yoshimura, Madoka; Nishino, Ichizo

    2015-09-01

    Distal myopathy with rimmed vacuoles or GNE myopathy, is an early adult-onset myopathy with slow progression that preferentially affects the tibialis anterior muscle. Severely affected patients show marked limb muscle atrophy together with respiratory dysfunction. The disease is caused by a mutation in the GNE gene that catalyzes two rate-limiting reactions in cytosolic sialic acid synthesis. Oral treatment with sialic acid metabolite prevents muscle atrophy and weakness in a mouse GNE myopathy model and a global Phase III study is currently underway. In addition, a global patient registry of neuromuscular cases is widely accepted as a useful tool to obtain epidemiological data and bolster patient recruitment for further development of this treatment strategy. PMID:26329152

  13. Donor corneoscleral rim contamination by gentamicin-resistant organisms

    Directory of Open Access Journals (Sweden)

    Gopinathan Usha

    1994-01-01

    Full Text Available Gentamicin is the most widely used antibiotic in the decontamination of donor cornea for penetrating keratoplasty. However, the incidence of resistance to gentamicin is on the rise. Bacterial isolates from 178 donor corneal rims were studied for gentamicin sensitivity. The overall rate of gentamicin resistance was 63.4%. At 86.2% the Pseudomonas. species had the highest rate of resistance, followed by Streptococci at 84.6%. The high rate of gentamicin resistance encountered by us and others suggest that either addition of a second antibiotic to corneal storage media or replacement of gentamicin by an antibiotic with a broader spectrum of activity may help reduce the risk of endophthalmitis following penetrating keratoplasty

  14. Soft tissue aneurysmal bone cyst

    Energy Technology Data Exchange (ETDEWEB)

    Wang, X.L.; Gielen, J.L.; Delrue, F.; De Schepper, A.M.A. [Department of Radiology, Universitair Ziekenhuis Antwerpen (University of Antwerp), Wilrijkstraat 10, 2650, Edegem (Belgium); Salgado, R. [Department of Pathology, Universitair Ziekenhuis Antwerpen (University of Antwerp), Wilrijkstraat 10, 2650, Edegem (Belgium)

    2004-08-01

    A soft tissue aneurysmal bone cyst located in the right gluteus medius of a 21-year-old man is reported. On conventional radiography, the lesion demonstrated a spherically trabeculated mass with a calcific rim. On CT scan, it showed a well-organized peripheral calcification resembling a myositis ossificans. On MRI, it presented as a multilocular, cystic lesion with fluid-fluid levels. The lesion had no solid components except for intralesional septa. Although findings on imaging and histology were identical to those described in classical aneurysmal bone cyst, diagnosis was delayed because of lack of knowledge of this entity and its resemblance to the more familiar post-traumatic heterotopic ossification (myositis ossificans). (orig.)

  15. Out of the Blue: The Pacific Rim as a Region

    Directory of Open Access Journals (Sweden)

    Arturo Santa-Cruz

    2005-08-01

    Full Text Available In 1993, in advance of what was to be the first Asia Pacific Economic Cooperation (APEC leader’s summit, US president Bill Clinton gave a lecture at Waseda University in Japan. In his speech, Clinton called for the creation of a “community of the Pacific.” The idea of a Pacific community is neither Clinton’s nor the Democratic Party’s invention, however. In the previous decade Ronald Reagan had already used it, going even beyond later conceptualizations, by referring to the 21st century as the Pacific’s century. But Reagan's prophecy concerning the Great Ocean was not new back in the 1980s either. In 1900 then US Secretary of State John Hay wrote: “the Mediterranean is the ocean of the past, the Atlantic the ocean of the present and the Pacific is the ocean of the future.” In a more general manner, as Christopher Coker has observed, the notion of the “Century of the Pacific” is plausible because it is consistent with the idea, popularized by Hegel, that the spirit of civilization is moving toward that part of the globe. Thus, the century of the Pacific has become a kind of zeitgeist. In this paper I undertake a conceptual, historical, and theoretical journey through the “Pacific Rim” or “Asia-Pacific,” as it has been called more recently. Although I will question the utility of the term, I want to make clear that my purpose is only to undertake a critical survey of “the Pacific.” As in any trip, however, one needs a starting point. But, What is the starting point of the Pacific Rim, that geographic zone that has been compared to Pascal’s sphere: “with periphery indeterminable and a center that may be anywhere”?

  16. Bone cement

    OpenAIRE

    Vaishya, Raju; Chauhan, Mayank; Vaish, Abhishek

    2013-01-01

    The knowledge about the bone cement is of paramount importance to all Orthopaedic surgeons. Although the bone cement had been the gold standard in the field of joint replacement surgery, its use has somewhat decreased because of the advent of press-fit implants which encourages bone in growth. The shortcomings, side effects and toxicity of the bone cement are being addressed recently. More research is needed and continues in the field of nanoparticle additives, enhanced bone–cement interface ...

  17. Subchondral bone failure in overload arthrosis: a scanning electron microscopic study in horses.

    Science.gov (United States)

    Norrdin, R W; Stover, S M

    2006-01-01

    Mechanical overload leads to a common arthrosis in the metacarpal condyle of the fetlock joint of racehorses. This is usually asymptomatic but severe forms can cause lameness. Subchondral bone failure is often present and the predictability of the site provided an opportunity to study of the progression of bone failure from microcracks to actual collapse of subchondral bone. Twenty-five fetlock condyles from racehorses with various stages of disease were selected. Stages ranged from mild through severe subchondral bone sclerosis, to the collapse of bone and indentation or loss of cartilage known as 'traumatic osteochondrosis'. Parasagittal slices were radiographed and examined with scanning electron microscopy. Fine matrix cracks were seen in the subchondral bone layer above the calcified cartilage and suggested loss of water or other non-collagenous components. The earliest microcracks appeared to develop in the sclerotic bone within 1-3 mm of the calcified cartilage layer and extend parallel to it in irregular branching lines. Longer cracks or microfractures appeared to develop gaps as fragmentation occurred along the margins. Occasional osteoclastic resorption sites along the fracture lines indicated activated remodeling may have caused previous weakening. In one sample, smoothly ground fragments were found in a fracture gap. Bone collapse occurred when there was compaction of the fragmented matrix along the microfracture. Bone collapse and fracture lines through the calcified cartilage were associated with indentation of articular cartilage at the site. PMID:17142946

  18. {sup 18}F-FDG PET/CT bone/bone marrow findings in Hodgkin's lymphoma may circumvent the use of bone marrow trephine biopsy at diagnosis staging

    Energy Technology Data Exchange (ETDEWEB)

    Moulin-Romsee, Gerard [Universite Paris 7, Service de Medicine Nucleaire, Hopital Saint-Louis, Assistance Publique-Hopitaux de Paris (France); Institut Curie, Nuclear Medicine, Paris (France); Hindie, Elif; Filmont, Jean-Emmanuel; Moretti, Jean-Luc [Universite Paris 7, Service de Medicine Nucleaire, Hopital Saint-Louis, Assistance Publique-Hopitaux de Paris (France); Cuenca, Xavier; Brice, Pauline; Sibon, David [Hopital Saint-Louis, Haemato-Oncology, Paris (France); Decaudin, Didier; Anitei, Marcela [Institut Curie, Haematology, Paris (France); Benamor, Myriam [Institut Curie, Nuclear Medicine, Paris (France); Briere, Josette [Hopital Saint-Louis, Pathology, Paris (France); Kerviler, Eric de [Hopital Saint-Louis, Radiology, Paris (France)

    2010-06-15

    Accurate staging of Hodgkin's lymphoma (HL) is necessary in selecting appropriate treatment. Bone marrow trephine biopsy (BMB) is the standard procedure for depicting bone marrow involvement. BMB is invasive and explores a limited part of the bone marrow. {sup 18}F-FDG PET/CT is now widely used for assessing response to therapy in HL and a baseline study is obtained to improve accuracy. The aim of this retrospective analysis was to assess whether routine BMB remains necessary with concomitant {sup 18}F-FDG PET/CT. Data from 83 patients (newly diagnosed HL) were reviewed. All patients had received contrast-enhanced CT, BMB and {sup 18}F-FDG PET/CT. Results of BMB were not available at the time of {sup 18}F-FDG PET/CT imaging. Seven patients had lymphomatous involvement on BMB. Four patients had bone involvement on conventional CT (two with negative BMB). All patients with bone marrow and/or bone lesions at conventional staging were also diagnosed on {sup 18}F-FDG PET/CT scan. PET/CT depicted FDG-avid bone/bone marrow foci in nine additional patients. Four of them had only one or two foci, while the other had multiple foci. However, the iliac crest, site of the BMB, was not involved on {sup 18}F-FDG PET/CT. Osteolytic/sclerotic lesions matching FDG-avid foci were visible on the CT part of PET/CT in three patients. MRI ordered in three other patients suggested bone marrow involvement. Interim and/or end-therapy {sup 18}F-FDG PET/CT documented response of FDG-avid bone/bone marrow foci to chemotherapy in every patient. {sup 18}F-FDG PET/CT highly improves sensitivity for diagnosis of bone/bone marrow lesions in HL compared to conventional staging. (orig.)

  19. Enchondroma on bone scan in a patient with breast cancer

    International Nuclear Information System (INIS)

    A 45-year-old postmenopausal woman with breast cancer was treated with modified radical mastectomy and radiotherapy. She remained clinically well for two years but then complained of pain in the left upper arm during a routine follow-up visit with her physician. A roentgenogram of the left proximal humerus showed a densely sclerotic, nonhomogeneous, 2 x 6 cm lesion with stippled calcification, the appearance of which was most consistent with a mature enchondroma or bone infarct. Because metastatic breast cancer was also a possibility, a technetium Tc 99m methyldiphosphonate (MDP) bone scan was done, revealing diffuse uptake in the left proximal humeral lesion, without any other area of involvement. Although radiologically the lesion appeared benign and stable, the history of breast cancer, abnormal bone scan, and pain could not be ignored, and open surgical bone biopsy was done. From deep within the lesion at the core of the metaphysis of the proximal left humerus, the surgeon removed an enchondroma, but found no evidence of metastatic disease. Follow-up MDP bone scans after six months and four years were unchanged

  20. 16 CFR Figure 8 to Part 1512 - Reflectorized Bicycle Wheel Rim Abrasion Test Device

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Reflectorized Bicycle Wheel Rim Abrasion... HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR BICYCLES Pt. 1512, Fig. 8 Figure 8 to Part 1512—Reflectorized Bicycle Wheel Rim Abrasion Test Device EC03OC91.074...

  1. Nonspecificity of the rim sign in the scintigraphic diagnosis of missed testicular torsion

    Energy Technology Data Exchange (ETDEWEB)

    Vieras, F.; Kuhn, C.R.

    1983-02-01

    Causes of a hyperemic peritesticular rim on dynamic and static scintigrams are reviewed. Of 6 patients exhibiting such a pattern, 3 had missed testicular torsion; the other 3 had tumor, trauma, or inflamation. The authors conclude that a hyperemic peritesticular rim is a nonspecific finding reflecting underlying pathophysiological changes and is not pathognomonic of missed torsion.

  2. From Theory to Practice: "Kaizen" and the Academy of the Pacific Rim

    Science.gov (United States)

    Blasdale, Spencer

    2004-01-01

    In this article, the author profiles the Academy of the Pacific Rim Charter Public School (Hyde Park, Massachusetts) and describes the school's culture. The school's students, who are in grades 6 through 12, are surrounded by rituals, routines, and relationship-building activities. Pacific Rim's culture stems from and supports the school's…

  3. Failure of a floating-rim generator rotor: Nipawin hydroelectric station

    Energy Technology Data Exchange (ETDEWEB)

    Callahan, G.E.

    1993-01-01

    This paper describes the problems experienced by SaskPower with the floating-rim design of the generator rotor as used on the three units at the Nipawin Hydroelectric Station. A brief description of the rebuild of the Unit 2 rotor is presented and the critical considerations of the floating-rim design of the rotor to ensure satisfactory service are examined.

  4. Complex chemical zoning in eclogite facies garnet reaction rims: the role of grain boundary diffusion

    Science.gov (United States)

    Prenzel, J.; Abart, R.; Keller, L.

    2009-03-01

    In metapelites of the Saualpe complex (Eastern Alps) continuous 10 µm to 20 µm wide garnet reaction rims formed along biotite-plagioclase and biotite-perthite interfaces. The pre-existing mineral assemblages are remnants of low pressure high temperature metamorphism of Permian age. The garnet reaction rims grew during the Cretaceous eclogite facies overprint. Reaction rim growth involved transfer of Fe and Mg components from the garnet-biotite interface to the garnet-feldspar interface and transfer of the Ca component in the opposite direction. The garnets show complex, asymmetrical chemical zoning, which reflects the relative contributions of short circuit diffusion along grain boundaries within the polycrystalline garnet reaction rims and volume diffusion through the grain interiors on bulk mass transfer. It is demonstrated by numerical modelling that the spacing of the grain boundaries, i.e. the grain size of the garnet in the reaction rim is a first order control on its internal chemical zoning.

  5. Structural outer rim of Chesapeake Bay impact crater: Seismic and bore hole evidence

    Science.gov (United States)

    Poag, C.W.

    1996-01-01

    Nine seismic-reflection profiles and four continuous core holes define the gross structural and stratigraphic framework of the outer rim of the Chesapeake Bay impact crater. The rim is manifested as a 90 km diameter ring of terraced normal-fault blocks, which forms a ???320 m-1200 m high rim escarpment. The top of the rim escarpment is covered by a 20 m-30 m thick ejecta blanket. The escarpment encircles a flat-floored annular trough, which is partly filled with an ???250 m thick breccia lens (Exmore breccia). The Exmore breccia overlies a 200 m-800 m thick interval of slumped sedimentary megablocks, which, in turn, rests on crystalline basement rocks. All postimpact strata (upper Eocene to Quaternary) sag structurally into the annular trough, and most units also thicken as they cross the rim into the crater. Postimpact compaction and subsidence of the Exmore breccia have created extensive normal faulting in overlying strata.

  6. Low Bone Density (Osteopenia)

    Science.gov (United States)

    ... are here Home » Low Bone Density Low Bone Density Low bone density is when your bone density ... people with normal bone density. Detecting Low Bone Density A bone density test will determine whether you ...

  7. Surface and internal structures of a space-weathered rim of an Itokawa regolith particle

    Science.gov (United States)

    Matsumoto, Toru; Tsuchiyama, Akira; Miyake, Akira; Noguchi, Takaaki; Nakamura, Michihiko; Uesugi, Kentaro; Takeuchi, Akihisa; Suzuki, Yoshio; Nakano, Tsukasa

    2015-09-01

    Surface morphologies of a regolith particle retrieved from Asteroid 25143 Itokawa were observed using field-emission scanning electron microscopy (FE-SEM). The images were compared with the internal structures of the space-weathered rim of the same particle observed by transmission electron and scanning transmission electron microscopies (TEM/STEM) to investigate whether there is a direct link between the surface morphology and internal structure. FE-SEM observation showed that most of the particle surface is covered by convex spots less than 100 nm in size. TEM/STEM observation revealed that this particle has a space-weathered rim composed of partially amorphous structures with nano-Fe particles and vesicles. The vesicles swell the surface and form blisters that correspond to the spotted structures observed by FE-SEM. These observations indicate that a space-weathered rim with blisters can be observed by FE-SEM without using destructive methods. The observation of the space-weathered rim by FE-SEM also enabled us to obtain the distribution of the space-weathered rim on the particle surfaces. The existence of space-weathered rims on the opposing surfaces of the particle shows that most of the surfaces were directly exposed to the space environment by movement on the Itokawa surface. The depths of the blister locations and the chemical composition of the space-weathered rim indicate that the observed space-weathered rim with blisters was formed mainly by solar wind irradiation. The space-weathered rim analyzed in this study is thicker than those of Itokawa particles previously examined, indicating that the rim may has experienced longer solar wind exposure than those previously observed.

  8. Imaging features of low-grade central osteosarcoma of the long bones and pelvis

    International Nuclear Information System (INIS)

    To determine the age and gender distribution and imaging features of low-grade central osteosarcoma (LGCOS) of the long bones and pelvis and to discuss our findings in the context of lesions for which LGCOS has been mistaken. We reviewed 99 cases of LGCOS collected between 1919 and 2002 from our institution and pathology consultation files. Adequate imaging was available in 70 cases (36 radiographs only, 17 radiographs/CT, 12 radiographs/MRI, 2 radiographs/CT/MRI, 2 CT only, 1 MRI only, 5 bone scans). Patient average age was 30.1±14.2 years, with a slight female predominance. The femur and tibia were the most common long bones involved (29 and 20 each) with the majority of these tumors arising around the knee, followed by the fibula, radius, humerus and ulna (four, three, two and one case each). Flat bones were involved in six cases (three pelvis, one rib, two scapulae). Short tubular bones were involved in five cases (two metatarsal, two phalanges, one clavicle). The lesion extended to the end of the affected long bone in 22 of 59 cases. Lesions were large at presentation (mean 7.9±4.6 cm, range 2-24). Four radiographic patterns were identified: lytic with varying amounts of thick and coarse trabeculation (n=22), predominantly lytic with few thin, incomplete trabecula (n=21), densely sclerotic (n=17) and mixed lytic and sclerotic (n=10). Lesions were benign-appearing overall with focally aggressive features. CT or MRI demonstrated cortical breech or extension into the soft tissues in all cases. LGCOS has a variable appearance on radiographs. A frequent pattern is a slow-growing large intracompartmental fibro-osseous lesion with varying amounts of septal ossification associated with focal areas of aggression. A homogeneously sclerotic pattern was also noted. Imaging with CT or MRI was helpful in every instance in our series in identifying areas of soft tissue extension or cortical disruption suggestive of a low-grade malignancy. (orig.)

  9. Imaging features of low-grade central osteosarcoma of the long bones and pelvis

    Energy Technology Data Exchange (ETDEWEB)

    Andresen, Kelli J.; Sundaram, Murali [Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN (United States); Unni, K. Krishnan [Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN (United States); Sim, Franklin H. [Department of Orthopedic Surgery, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN (United States)

    2004-07-01

    To determine the age and gender distribution and imaging features of low-grade central osteosarcoma (LGCOS) of the long bones and pelvis and to discuss our findings in the context of lesions for which LGCOS has been mistaken. We reviewed 99 cases of LGCOS collected between 1919 and 2002 from our institution and pathology consultation files. Adequate imaging was available in 70 cases (36 radiographs only, 17 radiographs/CT, 12 radiographs/MRI, 2 radiographs/CT/MRI, 2 CT only, 1 MRI only, 5 bone scans). Patient average age was 30.1{+-}14.2 years, with a slight female predominance. The femur and tibia were the most common long bones involved (29 and 20 each) with the majority of these tumors arising around the knee, followed by the fibula, radius, humerus and ulna (four, three, two and one case each). Flat bones were involved in six cases (three pelvis, one rib, two scapulae). Short tubular bones were involved in five cases (two metatarsal, two phalanges, one clavicle). The lesion extended to the end of the affected long bone in 22 of 59 cases. Lesions were large at presentation (mean 7.9{+-}4.6 cm, range 2-24). Four radiographic patterns were identified: lytic with varying amounts of thick and coarse trabeculation (n=22), predominantly lytic with few thin, incomplete trabecula (n=21), densely sclerotic (n=17) and mixed lytic and sclerotic (n=10). Lesions were benign-appearing overall with focally aggressive features. CT or MRI demonstrated cortical breech or extension into the soft tissues in all cases. LGCOS has a variable appearance on radiographs. A frequent pattern is a slow-growing large intracompartmental fibro-osseous lesion with varying amounts of septal ossification associated with focal areas of aggression. A homogeneously sclerotic pattern was also noted. Imaging with CT or MRI was helpful in every instance in our series in identifying areas of soft tissue extension or cortical disruption suggestive of a low-grade malignancy. (orig.)

  10. Bone Infections

    Science.gov (United States)

    ... of the body, bones can get infected. The infections are usually bacterial, but can also be fungal. ... bloodstream. People who are at risk for bone infections include those with diabetes, poor circulation, or recent ...

  11. Bone Tumor

    Science.gov (United States)

    ... develop when cells within a bone divide uncontrollably, forming a lump or mass of abnormal tissue. Most ... you have bone cancer, treatment will include a team of doctors from different medical specialties working together ...

  12. Bone Markers

    Science.gov (United States)

    ... may be seen in conditions such as: Osteoporosis Paget disease Cancer that has spread to the bone (metastatic ... has an unexpected bone fracture. Since people with breast or prostate cancer have a high incidence of ...

  13. 3He film flow on a round rim beaker

    International Nuclear Information System (INIS)

    The superfluid properties of thin (100-150 nm) of 3He were investigated by measuring the rate at which a beaker of liquid 3He emptied itself through the adsorbed film, with the film thickness ? decreasing as the level dropped. A beaker rim with a semicircular cross-section was used to provide a well defined geometry and to avoid the effects of small scratches that may have affected earlier experiments. The film thicknesses were determined by Atkins' oscillation measurements of 4He films on the same surface. The superfluid transition temperature in the film TFc was suppressed below the bulk value TBc, and was close to being described by 2?/?(TFc) = ?, as expected for A-phase. The critical current density was more than an order of magnitude smaller than expected for pair-breaking. When a 4He monolayer was adsorbed on the substrate, there was no suppression of TFc and the critical current density was much larger. With or without the 4He monolayer an abrupt decrease in the flow rate was observed as the film thinned, which may be associated with the B to A-phase transition that should occur

  14. Human Rights in the Countries of the Southern Rim

    Directory of Open Access Journals (Sweden)

    Laura Feliu i Martínez

    1997-09-01

    Full Text Available After practically all of the southern-rim countries of the Mediterranean gained their independence, the process of national construction has been predicated on authoritarian regimes. These regimes justified both the use of force against political opposition and the limits on rights and liberties on the need for maintaining the unanimity of the people which had manifested itself during the struggles for liberation from the colonial yoke. Towards the end of the 1980s, the regional and international context seemed to presage a very much longed for opening-up of the political scene after some of these countries (Tunisia, Algeria and Jordan initiated a series of movements that pointed to their democratisation. The posterior evolution of events has crushed those hopes in every case, and only Morocco and Jordan (each with their respective limitations appear to have evolved towards a softening of repression. The excuse put forth from the collection of states in the region to justify the step backwards is the existence of two threats they must act with forcefulness before: the threat of Islamic “fundamentalism” and the desire of certain groups to boycott the on-going Israeli-Palestinian Peace Process.

  15. CO observations of a molecular cloud complex associated with the bright rim near VY Canis Majoris

    International Nuclear Information System (INIS)

    Extensive CO observations of a large molecular cloud complex (approx. 15 pc) associated with a bright rim near the peculiar star VY CMa are presented. CO emission peaks in a region along and adjacent to the bright rim which forms the western border of the cloud complex. This emission abruptly decreases across the bright rim, and this decrease suggests a physical association of the rim with the cloud. The molecular complex is found to consist of two clouds which have different radial velocities and physical properties. The possibility that these two clouds may be in near-collision is discussed. The physical association of the bright rim with the cloud complex indicates that the clouds are at the same distance, 1.5 kpc, as the stars which excite the rim. Since VY CMa appears to be located at the tip of the bright rim and has a velocity similar to that of the molecular cloud complex and the stars of the cluster NGC 2362, it is concluded that VY CMa is also at the same distance. The resulting luminosity of VY CMa (5 x 105 L sub solar) indicates that the star is very massive, and places constraints on interpretation of its evolutionary state. 5 figures, 2 tables

  16. Near-IR Imaging Polarimetry toward a Bright-Rimmed Cloud: Magnetic Field in SFO 74

    CERN Document Server

    Kusune, Takayoshi; Miao, Jingqi; Tamura, Motohide; Sato, Yaeko; Kwon, Jungmi; Watanabe, Makoto; Nishiyama, Shogo; Nagayama, Takahiro; Sato, Shuji

    2014-01-01

    We have made near-infrared (JHKs) imaging polarimetry of a bright-rimmed cloud (SFO 74). The polarization vector maps clearly show that the magnetic field in the layer just behind the bright rim is running along the rim, quite different from its ambient magnetic field. The direction of the magnetic field just behind the tip rim is almost perpendicular to that of the incident UV radiation, and the magnetic field configuration appears to be symmetric as a whole with respect to the cloud symmetry axis. We estimated the column and number densities in the two regions (just inside and far inside the tip rim), and then derived the magnetic field strength, applying the Chandrasekhar-Fermi method. The estimated magnetic field strength just inside the tip rim, ~90 uG, is stronger than that far inside, ~30 uG. This suggests that the magnetic field strength just inside the tip rim is enhanced by the UV radiation induced shock. The shock increases the density within the top layer around the tip, and thus increases the str...

  17. Modelling of thermal conductivity for high burnup UO2 fuel retaining Rim region

    International Nuclear Information System (INIS)

    A thermal conductivity correlation has been proposed which can be applied to high burnup fuel by considering both of thermal conductivity with burnup across fuel pellet and additional degradation at pellet rim due to very high porosity. In addition, a correlation has been developed that can estimate the porosity of rim region as a function of rim burnup under the assumptions that all the produced fission gases are retained in the rim porosity and threshold pellet average burnup required for the formation of rim region is 40 MWD/kgU. Rim width is correlated to rim burnup using measured data. For the RISO experimental data obtained at pellet average burnup of 43.5 MWD/kgU for three linear heat generation rates of 30, 35 and 40 kW/m, radial temperature distributions were calculated using the present correlation and compared with the measured ones. This comparison shows that the present correlation gives the best agreement with the measured data when it is combined with the HALDEN's correlation for thermal conductivity considering its degradation with burnup. Another comparison with the HALDEN's measured fuel centerline temperature as a function of burnup at 25 kW/m up to about 44 MWD/kgU also suggests that the present correlation yields the best agreement when it is combined with the HALDEN's thermal conductivity. (author)

  18. CT Guided Bone Biopsy Using a Battery Powered Intraosseous Device

    Energy Technology Data Exchange (ETDEWEB)

    Schnapauff, Dirk, E-mail: dirk.schnapauff@charite.de; Marnitz, Tim, E-mail: tim.marnitz@charite.de; Freyhardt, Patrick, E-mail: Patrick.freyhardt@charite.de; Collettini, Federico, E-mail: Federico.collettini@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany); Hartwig, Kerstin, E-mail: kerstin.hartwig@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Haematology and Oncology (Germany); Joehrens, Korinna, E-mail: korinna.joehrens@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Pathology (Germany); Hamm, Bernd, E-mail: bernd.hamm@charite.de; Kroencke, Thomas, E-mail: thomas.kroencke@charite.de; Gebauer, Bernhard, E-mail: Bernhard.gebauer@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany)

    2013-10-15

    Purpose: To evaluate the feasibility of a battery powered intraosseous device to perform CT-fluoroscopy guided bone biopsy. Methods: Retrospective analysis of 12 patients in whom bone specimen were acquired from different locations under CT-fluoroscopy guidance using the OnControl bone marrow biopsy system (OBM, Vidacare, Shavano Park, TX, USA). Data of the 12 were compared to a historic cohort in whom the specimen were acquired using the classic Jamshidi Needle, as reference needle using manual force for biopsy. Results: Technical success was reached in 11 of 12 cases, indicated by central localisation of the needle within the target lesion. All specimen sampled were sufficient for histopathological workup. Compared to the historical cohort the time needed for biopsy decreased significantly from 13 {+-} 6 to 6 {+-} 4 min (P = 0.0001). Due to the shortened intervention time the radiation dose (CTDI) during CT-fluoroscopy was lowered significantly from 169 {+-} 87 to 111 {+-} 54 mGy Multiplication-Sign cm (P = 0.0001). Interventional radiologists were confident with the performance of the needle especially when using in sclerotic or osteoblastic lesions. Conclusion: The OBM is an attractive support for CT-fluoroscopy guided bone biopsy which is safe tool and compared to the classical approach using the Jamshidi needle leading to significantly reduced intervention time and radiation exposure.

  19. Bone metastases as the presenting manifestation of rhabdomyosarcoma in childhood

    International Nuclear Information System (INIS)

    Rarely, rhabdomyosarcoma can present with bone pain and bone lesions on radiographs without evidence of a primary tumor. Of 428 children with biopsy-proven rhabdomyosarcoma, four presented with radiographic evidence of bone metastases, but no primary tumor was found on subsequent evaluation. On radiographs, these metastases, located most commonly in the metaphyses of the extremities and in the spine, displayed a destructive or diffusely permeative pattern without sclerotic margins and mimicked the more common neuroblastoma. One patient also had diaphyseal cortical lytic metastases of the tibia. Radiographs defined metastases of the extremities better than the correlative bone scans. In the spine, on T2-weighted magnetic resonance (MR) images, metastases displayed high signal intensity which contrasted with the low-signal-intensity marrow in these pediatric patients. On histopathologic examination, metastatic rhabdomyosarcoma was composed of small cells of variable size, shape, and growth pattern similar to other round cell tumors. A positive desmin immunohistochemical test helped to establish the diagnosis. The radiologist, pathologist, and clinician should be aware of this unusual presentation of rhabdomyosarcoma so that suitable immunohistochemical tests are performed and appropriate chemotherapy given. (orig.)

  20. Bone metastases as the presenting manifestation of rhabdomyosarcoma in childhood

    Energy Technology Data Exchange (ETDEWEB)

    Shapeero, L.G. (Dept. of Radiology, Inst. Gustave-Roussy, Villejuif (France) Dept. of Radiology, California Univ., San Francisco, CA (United States)); Couanet, D. (Dept. of Radiology, Inst. Gustave-Roussy, Villejuif (France)); Vanel, D. (Dept. of Radiology, Inst. Gustave-Roussy, Villejuif (France)); Ackerman, L.V. (Dept. of Pathology, State Univ., Stony Brook, NY (United States)); Terrier-Lacombe, M.J. (Dept. of Pathology, Inst. Gustave-Roussy, Villejuif (France)); Flamant, F. (Dept. of Pediatrics, Inst. Gustave-Roussy, Villejuif (France)); Contesso, G. (Dept. of Pathology, Inst. Gustave-Roussy, Villejuif (France)); Lumbroso, J. (Dept. of Nuclear Medicine, Inst. Gustave-Roussy, Villejuif (France))

    1993-08-01

    Rarely, rhabdomyosarcoma can present with bone pain and bone lesions on radiographs without evidence of a primary tumor. Of 428 children with biopsy-proven rhabdomyosarcoma, four presented with radiographic evidence of bone metastases, but no primary tumor was found on subsequent evaluation. On radiographs, these metastases, located most commonly in the metaphyses of the extremities and in the spine, displayed a destructive or diffusely permeative pattern without sclerotic margins and mimicked the more common neuroblastoma. One patient also had diaphyseal cortical lytic metastases of the tibia. Radiographs defined metastases of the extremities better than the correlative bone scans. In the spine, on T2-weighted magnetic resonance (MR) images, metastases displayed high signal intensity which contrasted with the low-signal-intensity marrow in these pediatric patients. On histopathologic examination, metastatic rhabdomyosarcoma was composed of small cells of variable size, shape, and growth pattern similar to other round cell tumors. A positive desmin immunohistochemical test helped to establish the diagnosis. The radiologist, pathologist, and clinician should be aware of this unusual presentation of rhabdomyosarcoma so that suitable immunohistochemical tests are performed and appropriate chemotherapy given. (orig.)

  1. RIM, Munc13, and Rab3A interplay in acrosomal exocytosis

    Energy Technology Data Exchange (ETDEWEB)

    Bello, Oscar D.; Zanetti, M. Natalia [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Mayorga, Luis S. [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Michaut, Marcela A., E-mail: mmichaut@fcm.uncu.edu.ar [Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Instituto de Ciencias Basicas, Universidad Nacional de Cuyo, Mendoza (5500) (Argentina)

    2012-03-10

    Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: Black-Right-Pointing-Pointer RIM and Munc13 are present in human sperm and localize to the acrosomal region. Black-Right-Pointing-Pointer RIM and Munc13 are necessary for acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Munc13 participate before the acrosomal calcium efflux. Black-Right-Pointing-Pointer RIM, Munc13 and Rab3A interplay in human sperm acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Rab3A have critical roles in membrane docking.

  2. LE RÔLE DE RIM101p DANS LA RÉPONSE AU pH CHEZ CANDIDA ALBICANS

    OpenAIRE

    Weyler, Michael

    2007-01-01

    Rim101p est un facteur de transcription qui est activé par cleavage N-terminale à pH alcalin. Il régule ainsi la réponse au pH et joue aussi un rôle majeur dans la pathogenèse de la levure Candida albicans. Mon projet est d'identifier et d'étudier des gènes de surface régulés par Rim101p qui ont une fonction dans l'interaction hôte-levure.Une analyse du transcriptome suite à l'induction d'une forme tronquée et constitutivement active de Rim101p nous avait permis d'identifier et de classer 133...

  3. Amphibole Reaction Rims in Response to Decompression compared to Heating: An Experimental Approach

    Science.gov (United States)

    Browne, B. L.; Gardner, J. E.; Larsen, J.

    2003-12-01

    Amphiboles are an important magmatic mineral phase common to a variety of volcanic settings, and are especially sensitive to variations in the water content and temperature of the surrounding induced during magmatic ascent or heating accompanying magma mixing events. As magma rises toward the surface hydrous amphiboles, stable at high water pressures, break down in response to degassing of the surrounding melt. Reaction rims also form around amphiboles that are destabilized when mixing with hotter, more primitive magmas occurs. In this study, we compare the thickness, composition, and rate of formation of amphibole reaction rims during a series of isothermal decompression and isobaric heating experiments using dacite and andesite magmas erupted from Redoubt volcano, Alaska in 1989-1990. The 1989-90 Redoubt dacite pumice consists of magnesio-hornblendes, plagioclase, othropyroxene, and Fe-Ti oxides in a high-silica rhyolite glass. In contrast, 1989-90 Redoubt andesite contains pargasitic amphiboles, orthopyroxene, clinopyroxene, plagioclase, and Fe-Ti oxides in a rhyodacite glass. Our results indicate that the reaction rims formed in response to decompression are distinguishable in thickness, grain size, and type of mineral formed in the rims from those formed in response to heating, regardless of the type of amphibole studied. First, decompression induced rims were thinner (5- 50 um) compared to those developing in response to heating (25- 200 um). Decompression induced rim growth rate ranges from 0.3 to 0.6 um/day compared to heating induced rim growth rate, which ranges from 0.4 to 1.6 um/day. Second, decompression rims were finer-grained (5-15 um diameter crystals) compared to heating reaction rims (5- 35 um diameter crystals). And third, decompression rims are predominantly composed of orthopyroxene and plagioclase, with lesser amounts of Fe-Ti oxides, whereas reaction rims that grew in response to heating experiments were composed almost entirely of clinopyroxene and Fe-Ti oxides, with lesser amounts of orthopyroxene, and plagioclase. Because the results are independent of the type of amphibole studied, the physical characteristics of reaction rims around amphiboles from a given eruption may yield important information about the rates and types of pre-eruptive disequilibrium event that was the cause.

  4. Crystal Structure of the RIM1? C2B Domain at 1.7 Å Resolution†,¶

    OpenAIRE

    Guan, Rong; Dai, Han; Diana R Tomchick; Dulubova, Irina; Machius, Mischa; Südhof, Thomas C.; Rizo, Josep

    2007-01-01

    RIM proteins play critical roles in synaptic vesicle priming and diverse forms of presynaptic plasticity. The C-terminal C2B domain is the only module that is common to all RIMs, but is only distantly related to well-studied C2 domains, and its three-dimensional structure and interactions have not been characterized in detail. Using NMR spectroscopy, we now show that N- and C-terminal extensions beyond the predicted C2B domain core sequence are necessary to form a folded, stable RIM1? C2B dom...

  5. Bone poroelasticity.

    Science.gov (United States)

    Cowin, S C

    1999-03-01

    Poroelasticity is a well-developed theory for the interaction of fluid and solid phases of a fluid-saturated porous medium. It is widely used in geomechanics and has been applied to bone by many authors in the last 30 years. The purpose of this work is, first, to review the literature related to the application of poroelasticity to the interstitial bone fluid and, second, to describe the specific physical and modeling considerations that establish poroelasticity as an effective and useful model for deformation-driven bone fluid movement in bone tissue. The application of poroelasticity to bone differs from its application to soft tissues in two important ways. First, the deformations of bone are small while those of soft tissues are generally large. Second, the bulk modulus of the mineralized bone matrix is about six times stiffer than that of the fluid in the pores while the bulk moduli of the soft tissue matrix and the pore water are almost the same. Poroelasticity and electrokinetics can be used to explain strain-generated potentials in wet bone. It is noted that strain-generated potentials can be used as an effective tool in the experimental study of local bone fluid flow, and that the knowledge of this technique will contribute to the answers of a number of questions concerning bone mineralization, osteocyte nutrition and the bone mechanosensory system. PMID:10093022

  6. Out of the Blue: The Pacific Rim as a Region

    Directory of Open Access Journals (Sweden)

    Arturo Santa-Cruz

    2005-08-01

    Full Text Available In 1993, in advance of what was to be the first Asia Pacific Economic Cooperation (APEC leader’s summit, US president Bill Clinton gave a lecture at Waseda University in Japan. In his speech, Clinton called for the creation of a “community of the Pacific.” The idea of a Pacific community is neither Clinton’s nor the Democratic Party’s invention, however. In the previous decade Ronald Reagan had already used it, going even beyond later conceptualizations, by referring to the 21st century as the Pacific’s century. But Reagan's prophecy concerning the Great Ocean was not new back in the 1980s either. In 1900 then US Secretary of State John Hay wrote: “the Mediterranean is the ocean of the past, the Atlantic the ocean of the present and the Pacific is the ocean of the future.” In a more general manner, as Christopher Coker has observed, the notion of the “Century of the Pacific” is plausible because it is consistent with the idea, popularized by Hegel, that the spirit of civilization is moving toward that part of the globe. Thus, the century of the Pacific has become a kind of zeitgeist. In this paper I undertake a conceptual, historical, and theoretical journey through the “Pacific Rim” or “Asia-Pacific,” as it has been called more recently. Although I will question the utility of the term, I want to make clear that my purpose is only to undertake a critical survey of “the Pacific.” As in any trip, however, one needs a starting point. But, What is the starting point of the Pacific Rim, that geographic zone that has been compared to Pascal’s sphere: “with periphery indeterminable and a center that may be anywhere”?

  7. Comperative study on four different radiographic technics to image the navicular bone

    International Nuclear Information System (INIS)

    In this paper the conventional x-ray technique according to Oxspring is compared with tomography and digitalized picture techniques (digital luminescent radiography, computed tomography, nuclear magnetic resonance tomography) to establish whether an improved picture of the equine navicular bone is possible. Because of a lack of detail, nuclear magnetic resonance tomography and digital luminescent radiography show no advantage. With tomography good picture of the navicular bone as well as the sesamoidian canals is gained, but the bone structure is not sharply visible. In spite of small losses in picture resolution, the computed tomography gives a picture with good contour and bone structure as well as an excellent differentiation between the density of spongiotic and sclerotic bone. When considering the picture quality (contour and structure of the navicular bone as well as number, shape, depth and surroundings of the sesamoidian canals), costs and technical possibilities of the examination procedures, the x-ray technique according to Oxspring still remains the method of choice in examining the equine navicular bone

  8. {sup 99m}Tc-MDP pinhole bone scintigraphic feature of fibrovascular zone: a new diagnostic sign of osteoid osteoma

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Yong Whee [Sung Ae Hospital, Seoul (Korea, Republic of); Kim, Sung Hoon; Choi, Yeong Jin [Catholic University Medical School, Seoul (Korea, Republic of)

    2007-02-15

    Osteoid osteoma is a common benign tumor. Histologically, the tumor is characterized by the presence of the nidus, fibrovascular zone (FVZ) and reactive host bone scleroses of various intensities. A nidus consists of core meshwork of osteoid trabeculae, woven bone and osteoblastic rim and a FVZ, 1-2 mm rim, is composed of loose fibrovascular tissue and nerve fibers. The nidus and FVZ are readily identifiable on pathological specimen and CT when sclerosis is not too extensive. Recently on pinhole bone scan, we observed a peculiar rim sign that denoted FVZ in a patient with pathologically proven osteoid osteoma. Not previously described the sign appears to be pathognomonic of osteoid osteoma, uniquely providing metabolic information. The finding was correlated with that of radiography, CT and MRI and low power light microscopy.

  9. Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release

    OpenAIRE

    Takao-Rikitsu, Etsuko; Mochida, Sumiko; Inoue, Eiji; Deguchi-Tawarada, Maki; Inoue, Marie; Ohtsuka, Toshihisa; TAKAI, Yoshimi

    2004-01-01

    We have recently isolated a novel cytomatrix at the active zone (CAZ)–associated protein, CAST, and found it directly binds another CAZ protein RIM1 and indirectly binds Munc13-1 through RIM1; RIM1 and Munc13-1 directly bind to each other and are implicated in priming of synaptic vesicles. Here, we show that all the CAZ proteins thus far known form a large molecular complex in the brain, including CAST, RIM1, Munc13-1, Bassoon, and Piccolo. RIM1 and Bassoon directly bind to the COOH terminus ...

  10. Malignant bone pain: pathophysiology and treatment.

    Science.gov (United States)

    Mercadante, S

    1997-01-01

    The presence of bone metastases predicts the presence of pain and is the most common cause of cancer-related pain. Although bone metastases do not involve vital organs, they may determine deleterious effects in patients with prolonged survival. Bone fractures, hypercalcaemia, neurologic deficits and reduced activity associated with bone metastases result in an overall compromise in the patient's quality of life. A metastasis is a consequence of a cascade of events including a progressive growth at the primary site, vascularization phase, invasion, detachment, embolization, survival in the circulation, arrest at the site of a metastasis, extravasion, evasion of host defense and progressive growth. Once cancer cells establish in the bone, the normal process of bone turnover is disturbed. The different mechanisms responsible for osteoclast activation correspond to typical radiologic features showing lytic, sclerotic or mixed metastases, according to the primary tumor. The release of chemical mediators, the increased pressure within the bone, microfractures, the stretching of periosteum, reactive muscle spasm, nerve root infiltration and compression of nerves by the collapse of vertebrae are the possible mechanisms of malignant bone pain. Pain is often disproportionate to the size or degree of bone involvement. A comprehensive assessment including a trusting relationship with the patient, taking a careful history of the pain complaint, the characteristics of the pain, the evaluation of the psychological status of the patient, neurological examination, the reviewing of diagnostic studies and laboratory findings, and individualization of the therapeutic approach, should precede any treatment. Radiotherapy is the cornerstone of the treatment. Low doses given in a single session are safe and effective, and reduce distress and inconvenience associated with repeated session. Radioisotopes are more imprecise in delivering specific doses of radiation, but have less toxicity and easy administration as well as effectiveness in subclinical sites of metastases, although storage, dispensing and administration should be under strict control. Chemotherapy and endocrine therapy are difficult to measure in terms of pain relief. Prophylactic fixation surgery can lead to improved survival and quality of life of patients with bone metastases. Surgical treatment should be undertaken when fracture occurs. Careful selection of patients for surgical spinal decompression is required. The potential benefits of surgical interventions have to be tempered with patient survival. The use of analgesics according to the WHO ladder is recommended. There is no clear evidence that non-steroidal anti-inflammatory drugs (NSAIDs) have a specific efficacy in malignant bone pain. The difficulty with incident pain is not a lack of response to systemic opioids, but rather that the doses required to control the incidental pain produce unacceptable side-effects at rest. Alternative measures are often required. The inhibition of bone resorption and hypercalcaemia can be reduced by the use of bisphosphonates. This class of drugs potentiate the effects of analgesics in improving metastatic bone pain. Invasive techniques are rarely indicated, but may provide analgesia in the treatment of pain resistant to the other modalities. Neural blockade should never be used as the sole modality for malignant bone pain, but should be considered as a helpful in specific pain situations. Careful appraisal and the application of a correct approach should enable the patient with bone metastases to obtain an acceptable pain relief despite the advanced nature of their malignant disease. PMID:9060007

  11. Maturity of the Crater Rim Walls as a Function of the Crater Size

    Science.gov (United States)

    Sim, C. K.; Kim, S. S.; Jeong, M.

    2015-11-01

    The median grain size retrieved from ground-based polarimetry and optical maturity (OMAT) of the interior rim walls of ~140 craters of various size. We discuss the relationship between maturation rate and crater size.

  12. Rim pélvico de doador vivo-relacionado para transplante: relato de caso e revisão da literatura

    Directory of Open Access Journals (Sweden)

    Tobias August Siemens

    2015-09-01

    Full Text Available ResumoIntrodução:É cada vez maior a discrepância entre a fila de espera e a oferta para um transplante renal. Fica evidente a necessidade de se usar enxertos com critérios expandidos, como, por exemplo, rim pélvico, conforme relatamos a seguir.Relato de caso:Paciente masculino de 25 anos, com doença renal crônica estádio 5, recebe como enxerto rim pélvico do pai, 49 anos, com história prévia de hipertensão arterial sistêmica bem controlada e urolitíase há mais de 10 anos sem novos episódios. Função e anatomia do rim pélvico foram avaliadas com exames de imagem como ressonância magnética, tomografia computadorizada e cintilografia. Após rejeição inicial tratada adequadamente, paciente apresenta boa evolução.Conclusão:Para aumentar oferta de rins para doação, é possível a utilização de rim pélvico, desde que adequadamente estudado no pré-operatório.

  13. Systematic Ion Irradiation Experiments to Olivine: Comparison with Space Weathered Rims of Itokawa Regolith Particles

    Science.gov (United States)

    Matsumoto, T.; Tsuchiyama, A.; Watanabe, N.; Yasuda, K.; Miyake, A.; Nakauchi, Y.; Okada, T.; Abe, M.; Yada, T.; Uesugi, M.; Karouji, Y.; Nakato, A.; Hashiguschi, M.; Kumagai, K.

    2015-11-01

    We performed H and He ion irradiation experiments using olivine fragments, in order to reveal formation time-scales of space weathered rims and formation processes of blisters by solar wind irradiation.

  14. Search Efficient Representation of Healthcare Data based on the HL7 RIM

    Directory of Open Access Journals (Sweden)

    Razan Paul

    2010-12-01

    Full Text Available The Reference Information Model (RIM of Health Level Seven (HL7 standard is a conceptual information model for health care. Data of HL7 RIM Observation class are sparse, high dimensional, and require frequent schema change. Entity Attribute Value (EAV is the widely used solution to handle these above challenges of medical data, but EAV is not search efficient for knowledge extraction. In this paper, we have proposed a search efficient data model:  Optimized Entity Attribute Value (OEAV for physical representation of medical data as alternative of widely used EAV model. We have implemented EAV or OEAV individually to model RIM Observation class and used relational model for the remaining RIM classes. We have shown that OEAV is dramatically search efficient   and occupy less storage space compared to EAV.

  15. The Anatomy and Bulk Composition of CAI Rims in the Vigarano (CV3) Chondrite

    Science.gov (United States)

    Ruzicka, A.; Boynton, W. V.

    1993-07-01

    A striking feature of Ca,Al-rich inclusions (CAIs) in chondrites is the presence of mineralogical layers that typically form rim sequences up to 50 micrometers thick [1]. Many ideas regarding the origin of CAI rims have been proposed, but none are entirely satisfactory. The detailed mineralogy and bulk compositions of relatively unaltered CAI rims in the Vigarano (CV3) chondrite described here provide constraints on hypotheses of rim formation. Rim Mineralogy: CAIs in Vigarano consist of melilite (mel)- and spinel (sp)- rich varieties, both of which are rimmed [2]. Around mel-rich objects, the layer sequence is CAI interior --> sp-rich layer (sometimes absent) --> mel/anorthite (anor) layer --> Ti-Al-rich clinopyroxene (Tpx) layer --> Al- diopside (Al-diop) layer --> olivine (ol) +/- Al-diop layer --> host matrix. The sequence around sp-rich objects differs from this in that the mel/anor layer is absent. Both the sp-rich layer around mel-cored CAIs and the cores of sp-rich CAIs in Vigarano are largely comprised of a fine-grained (anor layer is sometimes monomineralic, consisting of mel alone, or bimineralic, consisting of both mel and anor. Where bimineralic, anor typically occurs in the outer part of the layer. In places, anor (An(sub)99-100) has partially altered to nepheline and voids. Rim mel is systematically less gehlenitic than mel in the CAI interiors, especially compared to mel in the interior adjacent to the rims. The Tpx layer (>2 and up to 15 wt% TiO2) and Al-diop layer ( sp + fo --> sp + fo + anor or mel or Tpx) that does not correspond to observed rim sequences. It thus appears that (1) the rim region did not form through crystallization of molten CAIs; and (2) rim layers did not originate solely by the crystallization of a melt layer present on a solid CAI core [4,5]. References: [1] Wark D. A. and Lovering J. F. (1977) Proc. LSC 8th, 95-112. [2] Ruzicka A. and Boynton W. V. (1991) Meteoritics, 26, 390-391. [3] Stolper E. (1982) GCA, 46, 2159-2180. [4] Korina M. I. et al. (1982) LPS XIII, 399- 400. [5] Bunch T. E. and Chang S. (1980) Meteoritics, 15, 270- 271.

  16. Reaction rim growth on olivine in silicic melts: Implications for magma mixing

    Science.gov (United States)

    Coombs, M.L.; Gardner, J.E.

    2004-01-01

    Finely crystalline amphibole or pyroxene rims that form during reaction between silicic host melt and cognate olivine xenocrysts, newly introduced during magma mixing events, can provide information about the timing between mixing and volcanic eruptions. We investigated rim growth experimentally by placing forsteritic olivine in rhyolitic and rhyodacitic melts for times between 25 and 622 h at 50 and 150 MPa, H2O-saturated, at the Ni-NiO buffer. Rims of orthopyroxene microlites formed from high-silica rhyolite and rhyodacite melts at 885??C and 50 MPa, and in the rhyolite at 150 MPa and 885??C. Rims of amphibole with lesser orthopyroxene formed in the rhyolite at 150 MPa and 800??C and in the rhyodacite at 150 MPa and 885??C. Irregular, convolute olivine edges and mass balance between olivine, melt, and rim phases show that olivine partly dissolved at all conditions. Iron-rich zones at the exteriors of olivines, which increased in width parabolically with time, show that Fe-Mg interdiffusion occurring in olivines was not outpaced by olivine dissolution. Linear increases of the square of rim widths with time suggest that diffusion within the melt is the rate-controlling process for olivine dissolution and rim growth. Rims grew one-half to one order-of-magnitude faster when melt water contents were doubled, unless conditions were far above the liquidus. Rim growth rate in rhyolite increases from 0.055 ?? 0.01 ??m2/h at 885 ??C and 50 MPa to 0.64 ?? 0.13 ??m2/h at 800 ??C and 150 MPa. Melt composition has a lesser effect on rim growth rates, with growth rate increasing as melt SiO2 content decreases. Pyroxene rims on olivines in andesite erupted from Arenal volcano (Costa Rica) grew at a rate of 3.0 ?? 0.2 ??m2/h over an eleven-year period. This rate is faster than those of the experiments due to lower melt viscosity and higher temperatures, and suggests that a magma mixing event preceded the start of the eruption by days.

  17. Radiological features of long bones in synovitis, acne, pustulosis, hyperostosis, osteitis syndrome and their correlation with pathological findings.

    Science.gov (United States)

    Orui, H; Takahara, M; Ishikawa, A; Takagi, M; Tsuchiya, T; Ogino, T

    2002-03-01

    Abstract The purpose of this study was to demonstrate the radiological features of long bones in synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome and to correlate these with the clinical findings. Eleven long bone lesions in seven cases of SAPHO syndrome were examined. The patients ranged in age from 6 to 63 years, with a mean of 47 years. In all seven cases, radiography, (99m)technetium bone scintigraphy, CT scan, and magnetic resonance imaging (MRI) were performed. In six of the cases, bone biopsy and bone culture were carried out for 7 long bones. Seven of the involved lesions were from the shaft of the femur, one each was from the neck and the shaft of the humerus, and one was from the proximal tibia. These lesions showed radiologically hyperostosis, osteolysis, and bone infarction-like lesion. Osteolysis was occasionally accompanied by sclerotic change. Hyperostosis usually showed diaphyseal involvement, presenting low signal intensity on T1- and T2-weighted MR images. Histologically, these findings corresponded to massive bone necrosis, new bone formation, fibrosis, or a mixture of these associated with mild inflammatory cell infiltration. Osteolysis involved dyaphysis, metaphysis, or epiphysis associated with arthritis, and presented low signal intensity on T1-weighted images, nonhomogeneous signal intensity lower than fat on T2-weighted images, and high signal intensity on fat suppression images. These findings corresponded to fibrosis, granulation, and inflammatory cell infiltration with lymphocyte aggregation. Bone infarction-like lesion was observed in the shaft or neck of the femur and the humerus and accompanied by calcification and cystic change. Bone cultures were negative in all cases in which bone biopsy was performed. Although hyperostosis is thought to be a characteristic bone lesion in SAPHO syndrome, the long bone lesion can occasionally show not only hyperostosis but also osteolytsis and bone infarction-like lesions. PMID:24383833

  18. Lateral Orbital Rim Osteotomy in the Treatment of Certain Skull Base Lesions

    OpenAIRE

    Pritz, Michael B.

    2002-01-01

    Quantitative data from a recent human cadaveric study suggested that removal of the lateral orbital rim alone may be sufficient to reach many targets for which the orbitozygomatic craniotomy has been used. Consequently, a lateral orbital rim osteotomy was substituted for an orbitozygomatic craniotomy in seven patients with a variety of pathologies located in the anterior, middle, and interpeduncular fossae. In each case, lateral orbitotomy provided a satisfactory surgical corridor for diagnos...

  19. On the Dark Rim Artifact in Dynamic Contrast-Enhanced MRI Myocardial Perfusion Studies

    OpenAIRE

    Di Bella, E.V.R.; Parker, D L; Sinusas, A. J.

    2005-01-01

    A dark band or rim along parts of the subendocardial border of the left ventricle (LV) and the myocardium has been noticed in some dynamic contrast-enhanced MR perfusion studies. The artifact is thought to be due to susceptibility effects from the gadolinium bolus, motion, or resolution, or a combination of these. Here motionless ex vivo hearts in which the cavity was filled with gadolinium are used to show that dark rim artifacts can be consistent with resolution effects alone.

  20. A Compact Array imaging survey of southern bright-rimmed clouds

    OpenAIRE

    Thompson, M. A.; Urquhart, J. S.; White, G. J.

    2003-01-01

    We have carried out a radio-wavelength imaging survey of 45 bright-rimmed clouds (BRCs), using the Australia Telescope Compact Array to characterise the physical properties in their ionised boundary layers. We detected radio emission from a total of 25 clouds and using a combination of Digitised Sky Survey and mid-infrared MSX micron images classified the emission into that associated with the ionised cloud rims, that associated with embedded possible massive YSOs and that u...

  1. Distal Myopathy with Rimmed Vacuoles : Impaired O-Glycan Formation in Muscular Glycoproteins

    OpenAIRE

    Tajima, Youichi; Uyama, Eiichiro; Go, Shinji; Sato, Chihiro; Tao, Nodoka; Kotani, Masaharu; Hino, Hirotake; Suzuki, Akemi; Sanai¶, Yutaka; Kitajima, Ken; Sakuraba, Hitoshi

    2005-01-01

    Distal myopathy with rimmed vacuoles (DMRV), is an autosomal recessive disorder with early adult onset, displays distal dominant muscular involvement and is characterized by the presence of numerous rimmed vacuoles in the affected muscle fibers. The pathophysiology of DMRV has not been clarified yet, although the responsible gene was identified as that encoding UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase involved in the biosynthesis of sialic acids. To identify defective ca...

  2. Comparison of measurements of neuroretinal rim area between confocal laser scanning tomography and planimetry of photographs

    OpenAIRE

    Jonas, J.; Mardin, C; Grundler, A.

    1998-01-01

    BACKGROUND—To compare neuroretinal rim area measurements by confocal scanning laser tomography and planimetric evaluation of optic disc photographs.?METHODS—For 221 patients with primary and secondary open angle glaucoma, 72 subjects with ocular hypertension, and 139 normal subjects, the optic disc was morphometrically analysed by the confocal scanning laser tomograph HRT (Heidelberg retina tomograph) and by planimetric evaluation of stereo colour optic disc photographs.?RESULTS—Absolute rim ...

  3. 99mTc MDP bone scan in evaluation of painful scoliosis

    International Nuclear Information System (INIS)

    A 18-year-old male presented with low back ache. The patient was investigated and was diagnosed to have painful scoliosis. X-ray and other examinations could not reveal any diagnosis. The patient was referred to undergo bone scan on clinical suspicion of osteoid osteoma and to rule out stress fracture if any. Planar bone scan was performed, which showed a lesion in L3 vertebra and was further evaluated with SPECT (Single photon emission computed tomography) study to characterize the lesion. On SPECT examination, the classical features of osteoid osteoma, the double density sign (11), was noted in the pars interarticularis region. These findings were confirmed by a CT scan, which showed a sclerotic lesion in pars interarticularis of L3 vertebra. The patient was posted for operation and was relieved of symptoms in the postoperative follow-up. (author)

  4. Magnetic Field Amplification in the Thin X-Ray Rims of SN 1006

    Science.gov (United States)

    Ressler, Sean M.; Katsuda, Satoru; Reynolds, Stephen P.; Long, Knox S.; Petre, Robert; Williams, Brian J.; Winkler, P. Frank

    2014-08-01

    Several young supernova remnants, including SN 1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50-100 ?G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, DvpropE ?. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the FWHM in terms of energy as FWHM \\propto Em_E? . Filament widths in SN 1006 decrease with energy; mE ~ -0.3 to -0.8, implying magnetic field amplification by factors of 10-50, above the factor of four expected in strong unmodified shocks. For SN 1006, the rapid shrinkage rules out magnetic damping models. It also favors short mean free paths (small diffusion coefficients) and strong dependence of D on energy (? >= 1).

  5. Magnetic-Field Amplification in the Thin X-ray Rims of SN1006

    CERN Document Server

    Ressler, Sean M; Reynolds, Stephen P; Long, Knox S; Petre, Robert; Williams, Brian J; Winkler, P Frank

    2014-01-01

    Several young supernova remnants (SNRs), including SN1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50 to $100 \\mu$G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic-field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic-field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, $D \\propto E^{\\mu}$. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the full widths at half maximum (FWHM) in terms of energy as FW...

  6. Magnetic field amplification in the thin X-ray rims of SN 1006

    International Nuclear Information System (INIS)

    Several young supernova remnants, including SN 1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50-100 ?G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, D?E ?. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the FWHM in terms of energy as FWHM ?E?mE. Filament widths in SN 1006 decrease with energy; mE ? –0.3 to –0.8, implying magnetic field amplification by factors of 10-50, above the factor of four expected in strong unmodified shocks. For SN 1006, the rapid shrinkage rules out magnetic damping models. It also favors short mean free paths (small diffusion coefficients) and strong dependence of D on energy (? ? 1).

  7. PET/MR imaging of bone lesions - implications for PET quantification from imperfect attenuation correction

    Energy Technology Data Exchange (ETDEWEB)

    Samarin, Andrei [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); University Hospital Zurich, Nuclear Medicine, Zurich (Switzerland); Burger, Cyrill; Crook, David W.; Burger, Irene A.; Schmid, Daniel T.; Schulthess, Gustav K. von; Kuhn, Felix P. [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); Wollenweber, Scott D. [GE Healthcare, Waukesha, WI (United States)

    2012-07-15

    Accurate attenuation correction (AC) is essential for quantitative analysis of PET tracer distribution. In MR, the lack of cortical bone signal makes bone segmentation difficult and may require implementation of special sequences. The purpose of this study was to evaluate the need for accurate bone segmentation in MR-based AC for whole-body PET/MR imaging. In 22 patients undergoing sequential PET/CT and 3-T MR imaging, modified CT AC maps were produced by replacing pixels with values of >100 HU, representing mostly bone structures, by pixels with a constant value of 36 HU corresponding to soft tissue, thereby simulating current MR-derived AC maps. A total of 141 FDG-positive osseous lesions and 50 soft-tissue lesions adjacent to bones were evaluated. The mean standardized uptake value (SUVmean) was measured in each lesion in PET images reconstructed once using the standard AC maps and once using the modified AC maps. Subsequently, the errors in lesion tracer uptake for the modified PET images were calculated using the standard PET image as a reference. Substitution of bone by soft tissue values in AC maps resulted in an underestimation of tracer uptake in osseous and soft tissue lesions adjacent to bones of 11.2 {+-} 5.4 % (range 1.5-30.8 %) and 3.2 {+-} 1.7 % (range 0.2-4 %), respectively. Analysis of the spine and pelvic osseous lesions revealed a substantial dependence of the error on lesion composition. For predominantly sclerotic spine lesions, the mean underestimation was 15.9 {+-} 3.4 % (range 9.9-23.5 %) and for osteolytic spine lesions, 7.2 {+-} 1.7 % (range 4.9-9.3 %), respectively. CT data simulating treating bone as soft tissue as is currently done in MR maps for PET AC leads to a substantial underestimation of tracer uptake in bone lesions and depends on lesion composition, the largest error being seen in sclerotic lesions. Therefore, depiction of cortical bone and other calcified areas in MR AC maps is necessary for accurate quantification of tracer uptake values in PET/MR imaging. (orig.)

  8. Rim 2/Hipa CACTA transposon display ; A new genetic marker technique in Oryza species

    Directory of Open Access Journals (Sweden)

    Lee Ju

    2005-03-01

    Full Text Available Abstract Background Transposons constitute the major fractions of repetitive sequences in eukaryotes, and have been crucial in the shaping of current genomes. Transposons are generally divided into two classes according to the mechanism underlying their transposition: RNA intermediate class 1 and DNA intermediate class 2. CACTA is a class 2 transposon superfamily, which is found exclusively in plants. As some transposons, including the CACTA superfamily, are highly abundant in plant species, and their nucleotide sequences are highly conserved within a family, they can be utilized as genetic markers, using a slightly modified version of the conventional AFLP protocol. Rim2 /Hipa is a CACTA transposon family having 16 bp consensus TIR sequences to be present in high copy numbers in rice genome. This research was carried out in order to develop a Rim2/Hipa CACTA-AFLP or Rim2/Hipa CACTA-TD (transposon display, hereafter Rim2/Hipa-TD protocol for the study of genetic markers in map construction and the study of genetic diversity in rice. Results Rim2/Hipa-TD generated ample polymorphic profiles among the different rice accessions, and the amplification profiles were highly reproducible between different thermocyclers and Taq polymerases. These amplification profiles allowed for clear distinction between two different ecotypes, Japonica and Indica, of Oryza sativa. In the analysis of RIL populations, the Rim2/Hipa-TD markers were found to be segregated largely in a dominant manner, although in a few cases, non-parental bands were observed in the segregating populations. Upon linkage analysis, the Rim2/Hipa-TD markers were found to be distributed in the regions proximal to the centromeres of the chromosomes. The distribution of the Rim2/Hipa CACTA elements was surveyed in 15 different Oryza species via Rim2/Hipa-TD. While Rim2/Hipa-TD yielded ample amplification profiles between 100 to 700 bp in the AA diploid Oryza species, other species having BB, CC, EE, BBCC and CCDD, profiles demonstrated that most of the amplified fragments were larger than 400 bp, and that our methods were insufficient to clearly distinguish between these fragments. However, the overall amplification profiles between species in the Oryza genus were fully distinct. Phenetic relationships among the AA diploid Oryza species, as evidenced by the Rim2/Hipa-TD markers, were matched with their geographical distributions. Conclusion The abundance of the Rim2/Hipa TIR sequences is very informative since the Rim2/Hipa-TD produced high polymorphic profiles with ample reproducibility within a species as well as between species in the Oryza genus. Therefore, Rim2/Hipa-TD markers can be useful in the development of high-density of genetic map around the centromeric regions. Rim2/Hipa-TD may also prove useful in evaluations of genetic variation and species relationships in the Oryza species.

  9. Bone densitometry

    DEFF Research Database (Denmark)

    Ravn, Pernille; Alexandersen, P; Møllgaard, A

    1999-01-01

    The bisphosphonates have been introduced as alternatives to hormone replacement therapy (HRT) for the treatment and prevention of postmenopausal osteoporosis. The expected increasing application in at clinical practice demands cost-effective and easily handled methods to monitor the effect on bone....... The weak response at the distal forearm during antiresorptive treatment has restricted the use of bone densitometry at this region. We describe a new model for bone densitometry at the distal forearm, by which the response obtained is comparable to the response in other regions where bone densitometry...... is much more expensive and technically complicated. By computerized iteration of single X-ray absorptiometry forearm scans we defined a region with 65% trabecular bone. The region was analyzed in randomized, double-masked, placebo- controlled trials: a 2-year trial with alendronate (n = 69), a 1-year...

  10. Tectonic setting of synorogenic gold deposits of the Pacific Rim

    Science.gov (United States)

    Goldfarb, R.J.; Phillips, G.N.; Nokleberg, W.J.

    1998-01-01

    More than 420 million oz of gold were concentrated in circum-Pacific synorogenic quartz loades mainly during two periods of continental growth, one along the Gondwanan margin in the Palaeozoic and the other in the northern Pacific basin between 170 and 50 Ma. These ores have many features in common and can be grouped into a single type of lode gold deposit widespread throughout clastic sedimentary-rock dominant terranes. The auriferous veins contain only a few percent sulphide minerals, have gold:silver ratios typically greater than 1:1, show a distinct association with medium grade metamorphic rocks, and may be associated with large-scale fault zone. Ore fluids are consistently of low salinity and are CO2-rich. In the early and middle Palaeozoic in the southern Pacific basin, a single immense turbidite sequence was added to the eastern margin of Gondwanaland. Deformation of these rocks in southeastern Australia was accompanied by deposition of at least 80 million oz of gold in the Victorian sector of the Lachlan fold belt mainly during the Middle and Late Devonian. Lesser Devonian gold accumulations characterized the more northerly parts of the Gondwanan margin within the Hodgkinson-Broken River and Thomson fold belts. Additional lodes were emplaced in this flyschoid sequence in Devonian or earlier Palaeozoic times in what is now the Buller Terrane, Westland, New Zealand. Minor post-Devonian growth of Gondwanaland included terrane collision and formation of gold-bearing veins in the Permian in Australia's New England fold belt and in the Jurassic-Early Cretaceous in New Zealand's Otago schists. Collision and accretion of dozens of terranes for a 100-m.y.-long period against the western margin of North America and eastern margin of Eurasia led to widespread, lattest Jurassic to Eocene gold veining in the northern Pacific basin. In the former location, Late Jurassic and Early Cretaceous veins and related placer deposits along the western margin of the Sierra Nevada batholith have yielded more than 100 million oz of gold. Additional significant ore-forming events during the development of North America's Cordilleran orogen included those in the Klamath Mountains region, California in the Late Jurassic and Early Cretaceous; the Klondike district, Yukon by the Early Cretaceous; the Nome and Fairbanks districts, Alaska, and the Bridge River district, British Columbia in the middle Cretaceous; and the Juneau gold belt, Alaska in the Eocene. Gold-bearing veins deposited during the Late Jurassic and Early Cretaceous terrane collision that formed the present-day Russian Far East have been the source for more than 130 million oz of placer gold. The abundance of gold-bearing quartz-carbonate veins throughout the Gondwanan, North American and Eurasian continental margins suggests the migration and concentration of large fluid volumes during continental growth. Such volumes could be released during orogenic heating of hydrous silicate mineral phases within accreted marine strata. The common temporal association between gold veining and magmatism around the Pacific Rim reflects these thermal episodes. Melting of the lower thickened crust during arc formation, slab rollback and extensional tectonism, and subduction of a slab window beneath the seaward part of the forearc region can all provide the required heat for initation of the ore-forming processes.

  11. Subsidence and basin-fill architecture of a lignite-bearing salt rim syncline: insights into rim syncline evolution and salt diapirism

    Science.gov (United States)

    Brandes, C.; Pollok, L.; Schmidt, C.; Wilde, V.; Winsemann, J.

    2012-04-01

    In the last decades, salt-withdrawal basins achieved much attention due to their significant hydrocarbon potential like in the Gulf of Mexico, along the Brazilian passive margin and in northern Germany. The Helmstedt-Staßfurt salt wall and the related Schöningen rim syncline are an ideal natural laboratory to study the evolution of salt-withdrawal basins in detail. An excellent data set of 358 wells allows a detailed assessment of the basin-fill architecture. The aim was to expand on the classical cross-section based rim syncline analysis by the use of 3D models and basin simulations. The Helmstedt-Staßfurt salt wall is 70 km long, 6-8 km wide and one of the most important diapiric structures in northern Germany, based on the economically significant lignite-bearing rim synclines. The analysed Schöningen rim syncline, located on the southwestern side of the Helmstedt-Staßfurt structure, is 8 km long and 3 km wide. The basin-fill is up to 366 m thick and contains 13 major lignite seams with thicknesses between 0.1 and 30 m. Cross-sections perpendicular to the basin axis indicate that the basin-fill has a pronounced lenticular shape. This shape varies from more symmetric in the NW to clearly asymmetric in the SE. It coincides to the broadening of the salt diapir from NW to SE. The geometry of the rim syncline therefore seems to be a function of the diapir morphology. Sediments close to a diapir margin tend to be sheared by the rising diapir and this effect is probably enhanced where the diapir becomes broader and as a result, the related rim syncline is more asymmetric. Isopach maps imply a two-fold depocentre evolution. The depocentre migrated over time towards the salt wall and also showed some distinct shifts parallel to the salt wall. The shifts parallel to salt wall were abrupt, in contrast to the more gradual migration of the depocentres perpendicular to the salt wall. The basin modelling part of the study was carried out with the software PetroMod®, which focused on the burial history of the rim syncline. Modeling results also show the progressive migration of the rim syncline depocenter towards the salt wall. The extracted geohistory curve shows initial rapid subsidence between 57 and 50 Ma and more moderate subsidence from 50 to 34 Ma. This pattern is interpreted to reflect salt migration from the source layer into the salt wall. The initial salt-withdrawal rate was rapid but later decreased probably due to depletion of the source layer. From a regional perspective, the sediments associated with the salt wall vary in age along strike. The oldest sediments are present at the northwestern and southeastern ends of the structure. The youngest sediments are present towards the central part of the salt wall. This age pattern implies that the break-through of the salt wall was initiated at the edges. The evolution of the Helmstedt-Staßfurt salt wall can be subdivided into the three stages reactive, active and passive diapirism. Initial salt rise was probably triggered by extension. Diapirism was enhanced due to contraction during the Late Cretaceous. The salt movements in the Tertiary were mainly driven by sediment loading in the rim synclines.

  12. Impact of slippage on the morphology and stability of a dewetting rim

    International Nuclear Information System (INIS)

    In this study lubrication theory is used to describe the stability and morphology of the rim that forms as a thin polymer film dewets from a hydrophobized silicon wafer. Thin film equations are derived from the governing hydrodynamic equations for the polymer to enable the systematic mathematical and numerical analysis of the properties of the solutions for different regimes of slippage and for a range of timescales. Dewetting rates and the cross sectional profiles of the evolving rims are derived for these models and compared to experimental results. Experiments also show that the rim is typically unstable in the spanwise direction and develops thicker and thinner parts that may grow into 'fingers'. Linear stability analysis as well as nonlinear numerical solutions are presented to investigate shape and growth rate of the rim instability. It is demonstrated that the difference in morphology and the rate at which the instability develops can be directly attributed to the magnitude of slippage. Finally, a derivation is given for the dominant wavelength of the bulges along the unstable rim.

  13. Modelling of Rim-layer features in frames of START-3 code development

    International Nuclear Information System (INIS)

    'Rim-effect' is a conventional term implying a number of microstructure and thermal physical phenomena, oriented from the periphery of a highly irradiated LWR fuel pellet, also called 'rim layer', 'rim', 'high burnup structure' (HBS) etc. One of the rim-effect consequences, important for fuel reliability, is evident intensification of fission gas release (FGR) and increase of rod internal pressure after certain threshold of fuel burnup. Results from post irradiation examinations (PIE) of WWER fuel demonstrate this tendency in a range of rod average burnup from 42-45 MWd/kgU to 60-65 Mwd/kgU. A recently developed dynamic model of FGR behavior based on analysis of a number of interrelated microstructure processes, differing by their rates and magnitudes and depending on external operational conditions, is briefly described in this paper. A verification of the model is performed using experimental data on matrix xenon EPMA and on fuel porosity. The verified model is integrated in the START-3 code and full-scale calculations of FGR are performed with the code. The developed model has demonstrated a good prediction for some important parameter of rim microstructure and for values of integral fission gas release in highly irradiated WWER fuel rods

  14. Seamless Rim-Functionalization of h-BN with Silica-Experiment and Theoretical Modeling.

    Science.gov (United States)

    Furlotti, Michele; Caputo, Riccarda; Krumeich, Frank; Nesper, Reinhard

    2015-05-18

    Boron nitride contains six-ring layers, which are isostructural to graphene, and it exhibits similar extraordinary mechanical strength. Unlike graphene, hexagonal boron nitride (h-BN) is an insulator and has some polar features that make it a perfect material for those applications graphene is not suitable for, for example, purely ionic conductors, insulating membranes, transparent coatings, composite ceramics, high oxidation resistance materials. We report here a selective rim-functionalization of h-BN with SiO2 by using the Stöber process. A closed, protruding ring of SiO2 is formed covering all edges perpendicular to the [001] zones of the h-BN stacks and thus shield the most reactive centers of BN layers. SEM and HAADF-STEM images, X-ray spectroscopy, and atomic force microscopy confirm the rim-functionalization by SiO2 . XRD demonstrates the absence of any intercalation phenomenon of BN and reveals the glassy nature of the SiO2 rims. Selected variations of synthesis and theoretical modeling both confirm that rim activation by water prior to the Stöber condensation is crucial. First-principles calculations also confirm that dangling bonds of clean BN edges merge to give interlayer bonds that make further functionalization much more difficult. The reported reaction pathway should allow for other new functionalizations of pure BN and of the rimmed SiO2 /h-BN composites. PMID:25873400

  15. Ancient stardust in fine-grained chondrule dust rims from carbonaceous chondrites

    Science.gov (United States)

    Leitner, Jan; Vollmer, Christian; Floss, Christine; Zipfel, Jutta; Hoppe, Peter

    2016-01-01

    Carbonaceous chondrites are fragments from primitive parent asteroids, which represent some of the most primitive meteorites accessible for laboratory analysis and offer therefore the best opportunity to explore the chemical and physical conditions in the early Solar System. Here, we report the identification of presolar grains, which are circumstellar condensates that date back from before the formation of our Solar System, in fine-grained dust rims around chondrules in carbonaceous chondrites. Average presolar grain abundances in the rims of aqueously altered chondrites (petrologic type 2) are three times higher than in the respective interchondrule matrices, while for the most pristine specimens (petrologic type 3), the opposite is observed. The presence of these grains implies a nebular origin of the rim material, and gives evidence for differing alteration pathways for different reservoirs of fine-grained material found in primitive meteorites. Moreover, our findings indicate formation of the fine-grained rims in the solar nebula prior to parent-body accretion, giving support to accretionary scenarios for parent-bodies in the presence of dust-rimmed chondrules.

  16. Acetabular rim and surface segmentation for hip surgery planning and dysplasia evaluation

    Science.gov (United States)

    Tan, Sovira; Yao, Jianhua; Yao, Lawrence; Summers, Ronald M.; Ward, Michael M.

    2008-03-01

    Knowledge of the acetabular rim and surface can be invaluable for hip surgery planning and dysplasia evaluation. The acetabular rim can also be used as a landmark for registration purposes. At the present time acetabular features are mostly extracted manually at great cost of time and human labor. Using a recent level set algorithm that can evolve on the surface of a 3D object represented by a triangular mesh we automatically extracted rims and surfaces of acetabulae. The level set is guided by curvature features on the mesh. It can segment portions of a surface that are bounded by a line of extremal curvature (ridgeline or crestline). The rim of the acetabulum is such an extremal curvature line. Our material consists of eight hemi-pelvis surfaces. The algorithm is initiated by putting a small circle (level set seed) at the center of the acetabular surface. Because this surface distinctively has the form of a cup we were able to use the Shape Index feature to automatically extract an approximate center. The circle then expands and deforms so as to take the shape of the acetabular rim. The results were visually inspected. Only minor errors were detected. The algorithm also proved to be robust. Seed placement was satisfactory for the eight hemi-pelvis surfaces without changing any parameters. For the level set evolution we were able to use a single set of parameters for seven out of eight surfaces.

  17. PATHOLOGIC BASIS FOR RIM ENHANCEMENT OBSERVED IN COMPUTED TOMOGRAPHIC IMAGES OF FELINE NASOPHARYNGEAL POLYPS.

    Science.gov (United States)

    Lamb, Christopher R; Sibbing, Kendall; Priestnall, Simon L

    2016-03-01

    In postcontrast computed tomographic (CT) images, feline nasopharyngeal polyps typically demonstrate enhancement of the peripheral rim. Computed tomographic images and histologic specimens of a case series of 22 cats with surgically removed nasopharyngeal polyps were reviewed retrospectively in an attempt to elucidate the origin of rim enhancement. Polyps were present in the tympanic cavity in 15 (68%) cats (three with extension into the nasopharynx), only in the nasopharynx in four (18%) cats, and only in the external ear canal in the remaining three (14%) cats. All polyps had variable degrees of epithelial injury. Hemorrhage and inflammatory infiltration were significantly more marked in the superficial stroma whereas edema was significantly more marked in the core stroma. In noncontrast CT images (n = 22), the tympanic bulla was thickened in all 15 cats with a polyp in the tympanic cavity and enlarged in eight (53%) of these cats. In postcontrast CT images (n = 15), an outer zone of relatively increased attenuation compatible with a rim was observed in 11 (73%) polyps. The magnitude and extent of rim enhancement in CT images was positively correlated with the histologic grade of inflammation in the superficial stroma and negatively correlated with the grade of edema in the superficial stroma. It appears that inflammation is the major determinant of contrast medium accumulation in feline nasopharyngeal polyps, and the tendency for inflammation to affect predominantly the superficial layers explains the frequent observation of a rim in postcontrast CT images. PMID:26763944

  18. Mechanical fracture study of nuclear fuel high burn-up structure (HBS or RIM) during annealing test; Etude de la fracturation mecanique de la structure a haut taux de combustion des combustibles irradies (RIM) en traitement thermique

    Energy Technology Data Exchange (ETDEWEB)

    Marcet, M.

    2010-12-07

    The ceramics used in Power Water Reactors ar made of uranium dioxide. Irradiated at high Burn-up, they present a characteristic zone in periphery called High Burn-Up Structure or RIM zone with micrometer pores containing over-pressurized gas bubbles. Annealing texts simulating incidental or accidental reactor situations, a strong release of the RIM zone is observed. We have considered that the fission gas release mechanism is the mechanical fracture of the RIM grain boundaries. The we have compared the different types of mechanical stress applied to a grain boundary with the fracture stress of the oxide. The first stress is due to RIM over-pressurized gas bubbles, these bubbles apply a stress field determined at a microscopic level i.e. at the gas bubbles scale and its local environment. The second stress is generated by the Pellet-Cladding Mechanical Interaction (PCMI). This stress applies a stress field on a microscopic scale i.e. at the RIM zone and its overall environment. The last stress is occurred by a strain due to the RIM structural evolution during annealing test. The experimental results show that microscopic and macroscopic stress fields to do not explain the RIM grain boundary fracture during annealing test. The stresses induced by the RIM structural evolution as a function of the temperature is a possible mechanism to explain the overall mechanical behavior of the RIM zone during annealing test. (author)

  19. Bone development

    DEFF Research Database (Denmark)

    Tatara, M.R.; Tygesen, Malin Plumhoff; Sawa-Wojtanowicz, B.; Krupski, W.; Majcher, P.; Harrison, Adrian Paul

    The objective of this study was to determine the long-term effect of alpha-ketoglutarate (AKG) administration during early neonatal life on skeletal development and function, with emphasis on bone exposed to regular stress and used to serve for systemic changes monitoring, the rib. Shropshire ram.......01). Furthermore, AKG administration induced significantly higher bone mineral density of the cortical bone by 7.1% (P<0.01) and improved the mechanical endurance of ribs in terms of the moments of maximum elastic strength and ultimate strength by 10% and 8%, respectively (P<0.05). It could be concluded that AKG...

  20. Cracking of an Aircraft Wheel Rim Made From Al-Alloy 2014-T6

    Directory of Open Access Journals (Sweden)

    G. Kosec

    2010-10-01

    Full Text Available Generally failures of different aircraft components and parts are revealed and examined by the use of non-destructive examination methods. In further detailed explanation and interpretation of failures optical and scanning electron microscopy are used. This paper deals with a problem of a crack on aircraft wheel rim made from aluminium alloy 2014-T6.The crack was observed during regular control by the maintenance unit for non-destructive examination of the Slovenian air carrier Adria Airways. The crack on the rim of an aircraft wheel investigated was a typical fatigue crack. At same time a numerous pits were found which served as stress concentrations on the rim surface.

  1. Mechanical fracture study of nuclear fuel high burn-up structure (HBS or RIM) during annealing test

    International Nuclear Information System (INIS)

    The ceramics used in Power Water Reactors ar made of uranium dioxide. Irradiated at high Burn-up, they present a characteristic zone in periphery called High Burn-Up Structure or RIM zone with micrometer pores containing over-pressurized gas bubbles. Annealing texts simulating incidental or accidental reactor situations, a strong release of the RIM zone is observed. We have considered that the fission gas release mechanism is the mechanical fracture of the RIM grain boundaries. The we have compared the different types of mechanical stress applied to a grain boundary with the fracture stress of the oxide. The first stress is due to RIM over-pressurized gas bubbles, these bubbles apply a stress field determined at a microscopic level i.e. at the gas bubbles scale and its local environment. The second stress is generated by the Pellet-Cladding Mechanical Interaction (PCMI). This stress applies a stress field on a microscopic scale i.e. at the RIM zone and its overall environment. The last stress is occurred by a strain due to the RIM structural evolution during annealing test. The experimental results show that microscopic and macroscopic stress fields to do not explain the RIM grain boundary fracture during annealing test. The stresses induced by the RIM structural evolution as a function of the temperature is a possible mechanism to explain the overall mechanical behavior of the RIM zone during annealing test. (author)

  2. Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution.

    Science.gov (United States)

    Guan, Rong; Dai, Han; Tomchick, Diana R; Dulubova, Irina; Machius, Mischa; Südhof, Thomas C; Rizo, Josep

    2007-08-01

    RIM proteins play critical roles in synaptic vesicle priming and diverse forms of presynaptic plasticity. The C-terminal C2B domain is the only module that is common to all RIMs but is only distantly related to well-studied C2 domains, and its three-dimensional structure and interactions have not been characterized in detail. Using NMR spectroscopy, we now show that N- and C-terminal extensions beyond the predicted C2B domain core sequence are necessary to form a folded, stable RIM1alpha C2B domain. We also find that the isolated RIM1alpha C2B domain is not sufficient for previously described protein-protein interactions involving the RIM1alpha C-terminus, suggesting that additional sequences adjacent to the C2B domain might be required for these interactions. However, analytical ultracentrifugation shows that the RIM1alpha C2B domain forms weak dimers in solution. The crystal structure of the RIM1alpha C2B domain dimer at 1.7 A resolution reveals that it forms a beta-sandwich characteristic of C2 domains and that the unique N- and C-terminal extensions form a small subdomain that packs against the beta-sandwich and mediates dimerization. Our results provide a structural basis to understand the function of RIM C2B domains and suggest that dimerization may be a crucial aspect of RIM function. PMID:17630786

  3. Young Stellar Population of the Bright-Rimmed Clouds BRC 5, BRC 7 and BRC 39

    OpenAIRE

    Panwar, Neelam; Chen, W. P.; Pandey, A.K.; Samal, M. R.; Ogura, K; Ojha, D. K.; Jose, J.; Bhatt, B. C.

    2014-01-01

    Bright-rimmed clouds (BRCs), illuminated and shaped by nearby OB stars, are potential sites of recent/ongoing star formation. Here we present an optical and infrared photometric study of three BRCs: BRC 5, BRC 7 and BRC 39 to obtain a census of the young stellar population, thereby inferring the star formation scenario, in these regions. In each BRC, the Class I sources are found to be located mostly near the bright rim or inside the cloud, whereas the Class II sources are p...

  4. Three-dimensional microstructural analysis of human lumber vertebrae using microcomputed tomography in bone metastasis from prostate cancer

    International Nuclear Information System (INIS)

    Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. However, the morphological details of bone metastasis of prostate cancer have not been clarified. The trabecular bone structure of bone metastasis from prostate cancer was investigated in three dimensions using microcomputed tomography (micro-CT). A total of 17 cubes of the lumber spine of a 77-year-old man with prostate cancer were excised post mortem: four of them from non-metastatic and the rest from metastatic sites. The samples were measured using micro-CT with a resolution of 23.2 ?m and the standard structural indices and degree of anisotropy were computed. After micro-CT measurement, the samples were tested in a destructive manner for the assessment of mechanical properties. Samples from the metastatic sites showed significantly higher values than those from non-metastatic sites for bone volume (BV), bone surface (BS), bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N) (p<0.005). Bone surface density (BS/BV) and trabecular separation (Tb.Sp) were significantly higher in the samples from non-metastatic sites (p<0.001). Samples from metastatic sites showed a more isotropic arrangement of trabecular bone than those from non-metastatic sites. Three-dimensionally reconstructed images depicted several different patterns of sclerotic bone metastasis, and osteolytic appearance was observed in all of them. Structural parameters such as BV/TV were well correlated with the mechanical properties (r=0.899). The present study clarified the trabecular microstructure of bone metastasis from prostate cancer and suggests that both osteolysis and osteogenesis progress while interacting with each other in all phases of bone metastasis. (author)

  5. Amphibole reaction rims as a record of pre-eruptive magmatic heating: An experimental approach

    Science.gov (United States)

    De Angelis, S. H.; Larsen, J.; Coombs, M.; Dunn, A.; Hayden, L.

    2015-09-01

    Magmatic minerals record the pre-eruptive timescales of magma ascent and mixing in crustal reservoirs and conduits. Investigations of the mineral records of magmatic processes are fundamental to our understanding of what controls eruption style, as ascent rates and magma mixing processes are well known to control and/or trigger potentially hazardous explosive eruptions. Thus, amphibole reaction rims are often used to infer pre-eruptive magma dynamics, and in particular to estimate magma ascent rates. However, while several experimental studies have investigated amphibole destabilization during decompression, only two investigated thermal destabilization relevant to magma mixing processes. This study examines amphibole decomposition experimentally through isobaric heating of magnesio-hornblende phenocrysts within a natural high-silica andesite glass. The experiments first equilibrated for 24 h at 870 °C and 140 MPa at H2O-saturated conditions and ƒO2 ? Re-ReO prior to rapid heating to 880, 900, or 920 °C and hold times of 3-48 h. At 920 °C, rim thicknesses increased from 17 ?m after 3 h, to 55 ?m after 12 h, and became pseudomorphs after longer durations. At 900 °C, rim thicknesses increased from 7 ?m after 3 h, to 80 ?m after 24 h, to pseudomorphs after longer durations. At 880 °C, rim thicknesses increased from 7 ?m after 3 h, to 18 ?m after 36 h, to pseudomorphs after 48 h. Reaction rim microlites vary from 5-16 ?m in size, with no systematic relationship between crystal size and the duration or magnitude of heating. Time-averaged rim microlite growth rates decrease steadily with increasing experimental duration (from 3.97 ×10-7 mms-1 to 3.1 to 3.5 ×10-8 mms-1). Time-averaged microlite nucleation rates also decrease with increasing experimental duration (from 1.2 ×103mm-3s-1 to 5.3 mm-3 s-1). There is no systematic relationship between time-averaged growth or nucleation rates and the magnitude of the heating step. Ortho- and clinopyroxene together constitute 57-90 modal % mineralogy in each reaction rim. At constant temperature, clinopyroxene abundances decrease with increasing experimental duration, from 72 modal % (3 h at 900 °C) to 0% (48 h at 880 °C, and 36 h at 900 and 920 °C). Fe-Ti oxides increase from 6-12 modal % (after 3-6 h) to 26-34 modal % (after 36-48 h). Plagioclase occurs in relatively minor amounts (500 ?m from reacted amphibole) are consistent with inter-microlite rim glasses (71.3-77.7 wt.% SiO2) within a given experiment and there is a weakly positive correlation between increasing run duration and inter-microlite melt SiO2 (68.9-78.5 wt.%). Our results indicate that experimental heating-induced amphibole reaction rims have thicknesses, textures, and mineralogies consistent with many of the natural reaction rims seen at arc-andesite volcanoes. They are also texturally consistent with experimental decompression reaction rims. On this basis it may be challenging to distinguish between decompression and heating mechanisms in nature.

  6. Disorders of Bone Remodeling

    OpenAIRE

    Feng, Xu; McDonald, Jay M.

    2011-01-01

    The skeleton provides mechanical support for stature and locomotion, protects vital organs, and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone modeling to carry out these crucial functions throughout life. Bone remodeling involves the removal of old or damaged bone by osteoclasts (bone resorption) and the subsequent replacement of new bone formed by osteoblasts (bone formation). Normal bone remodeling requires a tight coupling of bone resorption to bone f...

  7. Crystal structure of the RIM2 C2A-domain at 1.4 A resolution.

    Science.gov (United States)

    Dai, Han; Tomchick, Diana R; García, Jesús; Südhof, Thomas C; Machius, Mischa; Rizo, Josep

    2005-10-18

    RIMs are large proteins that contain two C2-domains and are localized at presynaptic active zones, where neurotransmitters are released. RIMs play key roles in synaptic vesicle priming and regulation of presynaptic plasticity. A mutation in the RIM1 C2A-domain has been implicated in autosomal dominant cone-rod dystrophy (CORD7). The RIM C2A-domain does not contain the full complement of aspartate residues that commonly mediate Ca2+ binding at the top loops of C2-domains, and has been reported to interact with SNAP-25 and synaptotagmin 1, two proteins from the Ca2+-dependent membrane fusion machinery. Here we have used NMR spectroscopy and X-ray crystallography to analyze the structure and biochemical properties of the RIM2 C2A-domain, which is closely related to the RIM1 C2A-domain. We find that the RIM2 C2A-domain does not bind Ca2+. Moreover, little binding of the RIM2 C2A-domain to SNAP-25 and to the C2-domains of synaptotagmin 1 was detected by NMR experiments, suggesting that as yet unidentified interactions of the RIM C2A-domain mediate its function. The crystal structure of the RIM2 C2A-domain using data to 1.4 A resolution reveals a beta-sandwich that resembles those observed for other C2-domains, but exhibits a unique dipolar distribution of electrostatic charges whereby one edge of the beta-sandwich is highly positive and the other edge is highly negative. The location of the mutation site implicated in CORD7 at the bottom of the domain and the pattern of sequence conservation suggest that, in contrast to most C2-domains, the RIM C2A-domains may function through Ca2+-independent interactions involving their bottom face. PMID:16216076

  8. Opportunities for Partnership in the Pacific Rim: Reflections on a Visit to Vietnam.

    Science.gov (United States)

    Sykes, Abel B., Jr.

    Community colleges are poised to play a vital role in Vietnam and other Pacific Rim nations currently seeking to develop their business sectors and economies. Projects and partnerships with U.S. community colleges are currently in progress in India, Malaysia, China, Japan, Taiwan, and Korea. In addition, the Vietnamese Ministry of Education and…

  9. How Do RIM-BPs Link Voltage-Gated Ca(2+) Channels to Evoked Neurotransmitter Release?

    Science.gov (United States)

    Li, Ying C; Kavalali, Ege T

    2015-09-23

    Coupling between voltage-gated Ca(2+) influx and synaptic vesicle exocytosis is essential for rapid evoked neurotransmission. Acuna et al. show that the knockout of RIM-BPs, which are key structural components of this coupling, decreases the reliability of evoked neurotransmitter release. PMID:26402594

  10. RIMS/sup tm/ - radiological information management system: software package EI-029-S86

    International Nuclear Information System (INIS)

    RIMS/sup tm/ has been developed for health physics record keeping and reporting. It provides for the management needs relating to radiological information control at a nuclear facility. The program is comprised of the following modules: Personnel Radiological Information, Radiological Work Permit, Radiation Survey Records, Access Control, ALARA Reporting, and Respirator and Survey Instrument Inventory Modules

  11. RIMS/sup tm/ - radiological information management system: software package EI-029-S86

    Energy Technology Data Exchange (ETDEWEB)

    1988-01-01

    RIMS/sup tm/ has been developed for health physics record keeping and reporting. It provides for the management needs relating to radiological information control at a nuclear facility. The program is comprised of the following modules: Personnel Radiological Information, Radiological Work Permit, Radiation Survey Records, Access Control, ALARA Reporting, and Respirator and Survey Instrument Inventory Modules.

  12. Incident laser modulation of a repaired damage site with a rim in fused silica rear subsurface

    International Nuclear Information System (INIS)

    Local CO2 laser treatment has proved to be an effective method to prevent the 351-nm laser-induced damage sites in a fused silica surface from exponentially growing, which is responsible for limiting the lifetime of optics in high fluence laser systems. However, the CO2 laser induced ablation crater is often surrounded by a raised rim at the edge, which can also result in the intensification of transmitted ultraviolet light that may damage the downstream optics. In this work, the three-dimensional finite-difference time-domain method is developed to simulate the distribution of electrical field intensity in the vicinity of the CO2 laser mitigated damage site located in the exit subsurface of fused silica. The simulated results show that the repaired damage sites with raised rims cause more notable modulation to the incident laser than those without rims. Specifically, we present a theoretical model of using dimpled patterning to control the rim structure around the edge of repaired damage sites to avoid damage to downstream optics. The calculated results accord well with previous experimental results and the underlying physical mechanism is analysed in detail. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  13. Constraints on the height of the inner disk rim in pre-main-sequence stars

    CERN Document Server

    Vinkovi?, Dejan

    2014-01-01

    The structure of inner region of protoplanetary disks around young pre-main-sequence stars is still poorly understood. This part of the disk is shaped by various forces influencing dust and gas dynamics and by dust sublimation, which creates abrupt drops in the dust density. This region also emits a strong near-infrared excess that cannot be explained by classical accretion disk models, which suggests the existence of some unusual dust distribution or disk shape. The most prevalent explanation to date is the puffed-up inner disk rim model, where the disk exhibits an optically thin cavity around the star up to the distance of dust sublimation. The critical parameter in this model is the inner disk rim height $z_{\\rm max}$ relative to the rim's distance from the star $R_{\\rm in}$. Observations often require $z_{\\rm max}/R_{\\rm in}\\gtrsim0.2$ to reproduce the near-infrared excess in the spectra. In this paper we put together a comprehensive list of processes that can shape the inner disk rim and combined them to...

  14. Fleeting Amyloid-like Forms of Rim4 Ensure Meiotic Fidelity.

    Science.gov (United States)

    Ford, Alice Flynn; Shorter, James

    2015-10-01

    Berchowitz et al. establish that transient amyloid-like forms of Rim4, a yeast RNA-binding protein with a predicted prion domain, translationally repress cyclin CLB3 in meiosis I, thereby ensuring homologous chromosome segregation. These findings suggest that prion domains might enable formation of tightly regulated amyloid-like effectors in diverse functional settings. PMID:26451477

  15. Effect of centrifugal load on crack path in thin-rimmed and webbed gears

    Directory of Open Access Journals (Sweden)

    F. Curà

    2015-10-01

    Full Text Available Thin rimmed and webbed gears are used in particular applications to reduce systems weight. This kind of gears need an accurate and fail safe design. As a matter of fact, a possible failure, due to bending fatigue, consists in crack nucleation and consequent growth, in particular in the tooth root zone. These cracks may propagate through the tooth or through the rim. Crack propagation direction is basically influenced by the wheel geometry parameters, above all the rim thickness. Studies available in literature emphasize three ranges for the backup ratio values, involving different behaviors. These ranges are related to the crack propagation paths; respectively through the tooth, through the rim and in an unforeseeable way. This last uncertainty zone depends on other parameters, related to both geometry and loading conditions. In this work the effect of wheel speed related to the bending load has been investigated. The investigation has been carried out by means of numerical models involving both 2D finite element and extended finite element models (XFEM. Results shows that both crack initiation point and crack propagation path are strongly influenced by centrifugal load; this effect is mainly evident in the uncertainty zone of the backup ratio

  16. TEMPERATURE TOLERANCE OF RED-RIMMED MELANIA MELANOIDES TUBERCUATA, (GASTROPODA: PROSOBRANCHIA: THIARIDAE)

    Science.gov (United States)

    The red-rimmed melania Melanoides tuberculata is an exotic aquatic snail of the family Thiaridae that is spreading across the southern United States and in geothermal waters in several midwestern and northwestern states. In addition to its potential to displace native mollusks it is known to harbor...

  17. Manned Mars Mission Exploration Zone: Eastern Rim of Hellas Impact Basin

    Science.gov (United States)

    Rice, J. W.; Crown, D. A.; Feldman, W. C.; Pathare, A. V.; Feustel, A. J.; Gertsch, L. S.

    2015-10-01

    Our proposed 200 km diameter Exploration Zone centered near 40°S; 104°E is located along the eastern rim of the Hellas basin which will allow astronauts to study and collect very ancient deep seated materials which were excavated in the impact event.

  18. Study on High Sensitive FFDL Technique for Monju and next generation SFR Using RIMS

    International Nuclear Information System (INIS)

    The high sensitive Failed Fuel Detection and Location technique for fast reactors has been developed using RIMS. Major achievements: - Tag gas (krypton and Xenon) was successfully identified with no concentration process in Joyo. - Burn-up of the failed fuel subassembly can be assumed. - Prototype FFDL system for Monju was proposed. ? Further enhancement of fast reactor safety

  19. 77 FR 18997 - Rim Lakes Forest Restoration Project; Apache-Sitgreavese National Forest, Black Mesa Ranger...

    Science.gov (United States)

    2012-03-29

    ... Forest Service Rim Lakes Forest Restoration Project; Apache-Sitgreavese National Forest, Black Mesa... classes represented, and restore frequent, periodic surface fire as an ecological process, as well as... action can meet its restoration objectives, and to assure consistency with the forest plan....

  20. Single stage reconstruction of alar rim defect using auricular composite graft: a case report

    Directory of Open Access Journals (Sweden)

    Soni A

    2005-01-01

    Full Text Available A case report of reconstruction of a post infective alar rim defect, in a girl of 13 years of age, occurring as a result of septic piercing of the nose, using a composite graft taken from the ear in a single stage is described.

  1. 76 FR 69720 - NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2011-11-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market... in the above-referenced proceeding of NaturEner Rim Rock Wind Energy, LLC's application for...

  2. Stereological evolution of the rim structure in PWR-fuels at prolonged irradiation: Dependencies with burn-up and temperature

    International Nuclear Information System (INIS)

    The stereology of the rim-structure was studied for PWR-fuels up to the ninth irradiation cycle, achieving maximum local burn-ups of 240 GWd/tM and beyond. At intermediate radial positions (0.55 0 c = 0.29. Rim-cavities are expected to remain closed at least up to this limit

  3. A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity

    Science.gov (United States)

    Read, Timothy; Richmond, Phillip A.; Dowell, Robin D.

    2016-01-01

    Most genetic variants associated with disease occur within regulatory regions of the genome, underscoring the importance of defining the mechanisms underlying differences in regulation of gene expression between individuals. We discovered a pair of co-regulated, divergently oriented transcripts, AQY2 and ncFRE6, that are expressed in one strain of Saccharomyces cerevisiae, ?1278b, but not in another, S288c. By combining classical genetics techniques with high-throughput sequencing, we identified a trans-acting single nucleotide polymorphism within the transcription factor RIM101 that causes the background-dependent expression of both transcripts. Subsequent RNA-seq experiments revealed that RIM101 regulates many more targets in S288c than in ?1278b and that deletion of RIM101 in both backgrounds abrogates the majority of differential expression between the strains. Strikingly, only three transcripts undergo a significant change in expression after swapping RIM101 alleles between backgrounds, implying that the differences in the RIM101 allele lead to a remarkably focused transcriptional response. However, hundreds of RIM101-dependent targets undergo a subtle but consistent shift in expression in the S288c RIM101-swapped strain, but not its ?1278b counterpart. We conclude that ?1278b may harbor a variant(s) that buffers against widespread transcriptional dysregulation upon introduction of a non-native RIM101 allele, emphasizing the importance of accounting for genetic background when assessing the impact of a regulatory variant. PMID:26751950

  4. 76 FR 69720 - NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2011-11-09

    ...Commission [ Docket No. ER12-295-000] NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based...the above-referenced proceeding of NaturEner Rim Rock Wind Energy, LLC's application for market-based rate...

  5. The kinetics of dolomite reaction rim growth under isostatic and non-isostatic pressure conditions

    Science.gov (United States)

    Helpa, V.; Rybacki, E.; Morales, L. G.; Abart, R.; Dresen, G. H.

    2013-12-01

    During burial and exhumation, rocks are simultaneously exposed to metamorphic reactions and tectonic stresses. Therefore, the reaction rate of newly formed minerals may depend on chemical and mechanical driving forces. Here, we investigate the reaction kinetics of dolomite (CaMg[CO3]2) rim growth by solid-state reactions experiments on oriented calcite (CaCO3) and magnesite (MgCO3) single crystals under isostatic and non-isostatic pressure conditions. Cylindrical samples of 3-5 mm length and 7 mm diameter were drilled and polished perpendicular to the rhombohedral cleavage planes of natural clear crystals. The tests were performed using a Paterson-type deformation apparatus at P = 400 MPa confining pressure, temperatures, T, between 750 and 850°C, and reaction durations, t, of 2 - 146 h to calculate the kinetic parameters of dolomite rim growth under isostatic stress conditions. For non-isostatic reaction experiments we applied in addition differential stresses, ?, up to 40 MPa perpendicular to the contact interface at T = 750°C for 4 - 171 h duration, initiating minor inelastic deformation of calcite. The thickness of the resulting dolomite reaction rims increases linearly with the square root of time, indicating a diffusion-controlled reaction. The rims consist of two different textural domains. Granular dolomite grains (? 2 -5 ?m grain size) form next to calcite and elongated palisade-shaped grains (1-6 ?m diameter) grow perpendicular to the magnesite interface. Texture measurements with the electron backscatter diffraction technique indicate that the orientations of dolomite grains are mainly influenced by the orientation of the calcite educt crystal, in particular in the granular rim. To some extent, the texture of dolomite palisades is also influenced by the orientation of magnesite. The thickness of the two individual layers increases with temperature. At 400 MPa isostatic pressure, T = 750°C and t = 29 hours, a 5 ?m thick granular dolomite layer and a 7 ?m thick palisade-shaped layer evolve. At similar conditions and a differential stress of 30 MPa, the rim thickness remains similar; consequently the effect of non-isostatic stress on dolomite rim growth is negligible. Platinum markers show that the initial calcite-magnesite interface is located between granular and palisade-forming dolomite, indicating that rim growth occurs by counter diffusion of MgO and CaO. Diffusion of MgO across the dolomite reaction rim into calcite forms additionally magnesio-calcite grains with diameters of ? 13 - 46 ?m, depending on the experimental conditions and increasing with increasing distance to the dolomite boundary. At T = 750°C, t = 29 hours, the thickness of the magnesio-calcite layer is 32 ?m (isostatic) - 35 ?m (? = 30 MPa). The experiments indicate that solid-state reaction rim growth of dolomite between calcite and magnesite is primarily controlled by diffusion of MgO and CaO, forming layers with different microstructures during growth into the educt phases. The kinetics of the reaction in the carbonate system are not significantly changed by differential stresses up to 40 MPa. We suggest that volume diffusion is the dominant transport mechanism, which is presumably less affected by non-isostatic stresses than grain boundary diffusion.

  6. [Bone transplant].

    Science.gov (United States)

    San Julián, M; Valentí, A

    2006-01-01

    We describe the methodology of the Bone and Soft Tissue Bank, from extraction and storage until use. Since the year 1986, with the creation of the Bone Bank in the University Clinic of Navarra, more than 3,000 grafts have been used for very different types of surgery. Bone grafts can be classified into cortical and spongy; the former are principally used in surgery to save tumour patients, in large post-traumatic reconstructions and in replacement surgery where there are massive bone defects and a structural support is required. The spongy grafts are the most used due to their numerous indications; they are especially useful in filling cavities that require a significant quantity of graft when the autograft is insufficient, or as a complement. They are also of special help in treating fractures when there is bone loss and in the treatment of delays in consolidation and pseudoarthrosis in little vascularized and atrophic zones. They are also used in prosthetic surgery against the presence of cavity type defects. Allografts of soft tissues are specially recognised in multiple ligament injuries that require reconstructions. Nowadays, the most utilised are those employed in surgery of the anterior cruciate ligament although they can be used for filling any ligament or tendon defect. The principal difficulties of the cortical allografts are in the consolidation of the ends with the bone itself and in tumour surgery, given that these are patients immunodepressed by the treatment, the incidence of infection is increased with respect to spongy grafts and soft tissues, which is irrelevant. In short, the increasingly widespread use of allografts is an essential therapeutic weapon in orthopaedic surgery and traumatology. It must be used by expert hands. PMID:16998521

  7. Iron-Manganese Redox Reactions in Endeavour Crater Rim Apron Rocks

    Science.gov (United States)

    Ming, D. W.; Mittlefehldt, D. W.; Gellert, R.; Peretyazhko, T.; Clark, B. C.; Morris, R. V.; Yen, A. S.; Arvidson, R. E.; Crumpler, L. S.; Farrand, W. H.; Grant, J. A., III; Jolliff, B. L.; Parker, T. J.; Schroder, C.

    2015-01-01

    The Mars Exploration Rover Opportunity has been exploring Noachian age rocks and outcrops on the rim of the 22 km diameter Endeavour crater since August 2011. The Cape York area is a low-lying rim of Endeavour that contains 3 distinct lithologies: 1) the stratigraphically lowest Matijevic fm of pre-impact lithology, 2) Shoemaker fm of impact breccias, and 3) the stratigraphically highest rim lithology Grasberg fm of post-impact sediments that drape the lower slopes of the rim. The sulfate-rich sediment of the Burns fm lies unconformably over the Grasberg fm. Ca-sulfate veins were discovered in Grasberg fm sediments; the sulfates precipitated from aqueous fluids flowing upward through these materials. Opportunity investigated the chemistry and morphology of outcrops in the Matijevic fm that have Fe(sup 3+)-rich smectite detected by orbital signatures returned by CRISM on MRO. Matijevic fm also contains "boxwork" fractures with chemistry consistent with an Al-rich smectite and veins that appear to be rich in Ca-sulfate. More recently on Cape Tribulation, Opportunity has characterized two S-, Mg- and Mn-rich rich rocks overturned and fractured by the rover's wheels on Cook Haven. Those rocks have been dubbed "Pinnacle Island" and "Stuart Island" and will be referred to as the "Island" rocks. The objectives of this study are to characterize the Fe and Mn contents in the Cape York materials, including the two Island rocks, and to provide a model for Mn mobilization and precipitation. Detailed geochemistry of Endeavour rim rocks is presented in a companion paper. Geochemical trends and elemental associations were obtained from data returned by the Alpha Particle X-ray Spectrometer (APXS) on Opportunity.

  8. Recent studies on the formation of the rim structure and on polygonization in LWR fuel

    International Nuclear Information System (INIS)

    At cross sectional burnups in excess of - 40 MWd/kgUO2, a grain subdivision process occurs at the outer rim of LWR UO2 fuel. A similar phenomenon can be observed in the Pu-rich inclusions in MOX fuel. Three phenomena are usually observed in the resulting 'Rim zone': formation of small grains of sub?m size, formation of pores of about ?m size, and reduction of the signal of fission Xe in EPMA measurements. The mechanisms for rim-structure formation are still not fully understood, and it is not completely obvious, whether the above three processes occur simultaneously or one after the other in sequential steps. Also, two different types of small grains have recently been found at CEA in France.The present state of knowledge on rim structure formation in LWR fuel is reviewed, as well as recent progress in observing and understanding the formation of nanocrystals and of polygonization in other ceramics. Controlled ion irradiation techniques, including fission product ions at fission energy (e.g. 72 MeV iodine ions) have been applied to UO2 and to simulated high burnup UO2, so-called SIMFUEL. The process of polygonization, i.e. the rearrangement of dislocations into dislocation walls forming low energy 'sub-boundaries' and rather perfect, but slightly misoriented subgrains, was studied in these experiments. The same experiments confirmed the extreme radiation stability of UO2 and demonstrated effects of fission spikes: fission-induced bubble formation, re-solution of fission gases from bubbles and fission-enhanced gas diffusion and release. No temperature dependence was found between room temperature and 500 deg. C. The combined results are used to discuss possible mechanisms for polygonization and rim structure formation in UO2. (author)

  9. Surgery for Bone Cancer

    Science.gov (United States)

    ... grafts or by bone cement. Bone cement: The bone cement PMMA (polymethylmethyacrylate) starts out as a liquid and hardens over time. It can be put into a hole in the bone in liquid form. As PMMA hardens, it gives ...

  10. Bone marrow aspiration

    Science.gov (United States)

    ... the hollow part of most bones. Bone marrow aspiration is the removal of a small amount of ... tissue in liquid form for examination. Bone marrow aspiration is not the same as bone marrow biopsy . ...

  11. Broken Bones (For Parents)

    Science.gov (United States)

    ... a Broken Bone Heal? Preventing Broken Bones The harder kids play, the harder they fall. The fact is, broken bones , or ... in line with one another), it may be harder to tell. Some telltale signs that a bone ...

  12. What causes bone loss?

    Science.gov (United States)

    ... cause. Other times, bone loss and thin bones run in families. In general, white, elderly women are ... at risk of falling and breaking a bone. Smoking. Men and women who smoke have weaker bones. ...

  13. NEW MOLECULES IN THE TUMOR NECROSIS FACTOR LIGAND AND RECEPTOR SUPERFAMILIES WITH IMPORTANCE FOR PHYSIOLOGICAL AND PATHOLOGICAL BONE RESORPTION.

    Science.gov (United States)

    Lerner, Ulf H.

    2004-01-01

    Osteoclasts are tissue-specific polykaryon bone-resorbing cells derived from the monocyte/macrophage hematopoietic lineage with specialized functions required for the adhesion of the cells to bone and the subsequent polarization of the cell membrane, secretion of acid to dissolve mineral crystals, and release of proteolytic enzymes to degrade the extracellular matrix proteins. Most pathological conditions in the skeleton lead to loss of bone due to excess osteoclastic bone resorption, including periodontal disease, rheumatoid arthritis, and osteoporosis. In rare cases, most of them genetic, patients with osteopetrosis exhibit sclerotic bone due either to a lack of osteoclasts or to non-functional osteoclasts. Mainly because of phenotypic findings in genetically manipulated mice or due to spontaneous mutations in humans, mice, and rats, several genes have been discovered as being crucial for osteoclast formation and activation. Recent breakthroughs in our understanding of osteoclast biology have revealed the critical roles in osteoclast differentiation played by RANKL, RANK, and OPG, three novel members of the tumor necrosis factor ligand and receptor superfamilies. The further study of these molecules and downstream signaling events are likely to provide a molecular basis for the development of new drugs for the treatment of diseases with excess or deficient osteoclastic bone resorption. PMID:15059943

  14. A magnetic resonance imaging study on changes in rat mandibular bone marrow and pulp tissue after high-dose irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Wan; Lee, Byung Do [Dept. of Oral and Maxillofacial Radiology and Wonkwang Dental Research Institute, College of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Lee, Kang Kyoo [Dept. of Radiation Oncology, School of Medicine, Wonkwang University, Iksan (Korea, Republic of); Koh, Kwang Joon [Dept. of Oral and Maxillofacial Radiology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju (Korea, Republic of)

    2014-03-15

    This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow.

  15. Solitary myofibroma of the lumbar vertebra: adult case

    Energy Technology Data Exchange (ETDEWEB)

    Konishi, E.; Yanagisawa, A. [Kyoto Prefectural University of Medicne, Department of Pathology, Kyoto (Japan); Mazaki, T.; Urata, Y. [Kyoto City Hospital, Department of Pathology, Kyoto (Japan); Tanaka, K.; Kanoe, H.; Ikenaga, M. [Kyoto City Hospital, Department of Orthopedic Surgery, Kyoto (Japan); Hayakawa, K. [Kyoto City Hospital, Department of Radiology, Kyoto (Japan)

    2007-06-15

    We present the first known adult case of solitary myofibroma of bone, which affected a lumbar vertebra in a 33-year-old male. Radiography identified a purely lytic lesion with a sclerotic rim in the right pedicle of L1. CT showed an expansile lytic lesion with a sclerotic rim. MRI of the lesion revealed an isointense signal on T1-weighted images, an inhomogeneously hyperintense signal on T2-weighted images, and marked enhancement with gadolinium. Pathological study showed a mixed picture of nodular proliferation of spindle-shaped myoid cells and hemangiopericytomatous proliferation of short spindle/small round cells. The tumor cells were immunoreactive for smooth muscle actin and immunonegative for desmin. This case of solitary myofibroma of bone is exceptionally rare because of its occurrence in an adult older than 20 years of age and its location at an extra-craniofacial site. (orig.)

  16. Solitary myofibroma of the lumbar vertebra: adult case

    International Nuclear Information System (INIS)

    We present the first known adult case of solitary myofibroma of bone, which affected a lumbar vertebra in a 33-year-old male. Radiography identified a purely lytic lesion with a sclerotic rim in the right pedicle of L1. CT showed an expansile lytic lesion with a sclerotic rim. MRI of the lesion revealed an isointense signal on T1-weighted images, an inhomogeneously hyperintense signal on T2-weighted images, and marked enhancement with gadolinium. Pathological study showed a mixed picture of nodular proliferation of spindle-shaped myoid cells and hemangiopericytomatous proliferation of short spindle/small round cells. The tumor cells were immunoreactive for smooth muscle actin and immunonegative for desmin. This case of solitary myofibroma of bone is exceptionally rare because of its occurrence in an adult older than 20 years of age and its location at an extra-craniofacial site. (orig.)

  17. Bone scans

    International Nuclear Information System (INIS)

    Oftentimes, in managing podiatric complaints, clinical and conventional radiographic techniques are insufficient in determining a patient's problem. This is especially true in the early stages of bone infection. Bone scanning or imaging can provide additional information in the diagnosis of the disorder. However, bone scans are not specific and must be correlated with clinical, radiographic, and laboratory evaluation. In other words, bone scanning does not provide the diagnosis but is an important bit of information aiding in the process of diagnosis. The more useful radionuclides in skeletal imaging are technetium phosphate complexes and gallium citrate. These compounds are administered intravenously and are detected at specific time intervals postinjection by a rectilinear scanner with minification is used and the entire skeleton can be imaged from head to toe. Minification allows visualization of the entire skeleton in a single image. A gamma camera can concentrate on an isolated area. However, it requires multiple views to complete the whole skeletal image. Recent advances have allowed computer augmentation of the data received from radionucleotide imaging. The purpose of this chapter is to present the current radionuclides clinically useful in podiatric patients

  18. Osteoclasts prefer aged bone

    DEFF Research Database (Denmark)

    Henriksen, K; Leeming, Diana Julie; Byrjalsen, I; Nielsen, R H; Sorensen, M G; Dziegiel, Morten Hanefeld; Martin, T John; Christiansen, C; Qvist, P; Karsdal, M A

    2007-01-01

    We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of...... aged bones....

  19. Favorable outcome of a total hip arthroplasty with insufficient bone coverage of the roof reinforcement ring

    Science.gov (United States)

    Judas, Fernando M.; Lucas, Francisco M.; Fonseca, Ruben L.

    2015-01-01

    Introduction Total hip arthroplasty in patients with developmental dysplasia of the hip can be a complex procedure due to acetabular and proximal femoral deformities. Presentation of case A 59-year-old male patient underwent a total hip arthroplasty for the treatment of end-stage dysplastic osteoarthritis. A roof reinforcement ring, a cemented polyethylene cup, and a cementless stem were used. A portion of the superior rim of the ring was uncovered by the host bone. Morsellized autogenous femoral-head graft was impacted to fill the space between the superior rim of the ring and the superior part of the dysplastic acetabulum. At the follow-up after 5-years, the patient had no complaints and was very satisfied with the operation result. The hip radiograph revealed no signs of instability of the acetabular component, and no bone graft resorption. Discussion Favorable results were described using metal rings and conical femoral stems for the treatment of the developmental dysplasia of the hip. The superior rim of the metal ring should be against host bone for 60% of its support. Despite the suboptimal implantation of the ring compromising, apparently, mechanical stability of the arthroplasty, the outcome was favorable. Conclusion This result can be supported by the good fixation of the metal ring to the pelvis with screws, the adequate orientation of both components of the total hip arthroplasty, and the bone graft incorporation. PMID:26453941

  20. Clinical and biologic behavior of bone metastases from differentiated thyroid carcinoma

    International Nuclear Information System (INIS)

    Thirty (3.8%) of 780 patients with differentiated thyroid cancer seen between 1970 and 1987 had bone metastases. The primary tumor was follicular in 26 patients and papillary in four. Mean age at diagnosis was 61 years. The manifestation of bone metastases was the presenting symptom in 18 patients (60%). Treatment included total thyroidectomy, levothyroxine sodium therapy, and radioactive iodine treatments. Twenty-seven patients had bone metastases from the initial observation, with 44 sites involved. Of the sites, 27 (61%) were shown both on iodine 131 whole-body scan (WBS) and on x-ray film, 11 (25%) only on WBS, and six (14%) only on x-ray film. Multiple involvement was observed in 11 patients. The radiologic appearance was invariably osteolytic. Serum thyroglobulin was elevated in all patients. After radioactive iodine, no WBS+/X-ray+ metastases showed a complete response, although a sclerotic border was noted in several cases, whereas six WBS+/X-ray- lesions were no longer detectable by WBS. Treatment with radioactive iodine and bone surgery resulted in a complete cure in three patients and in a reduction of tumor mass in three. Twenty-one (70%) of the patients died of thyroid cancer after a mean survival of 86 months. Of the nine patients still alive, two are free of disease, three have a good quality of life, and four have severe disability

  1. Pinhole bone scan mapping of metabolic profiles in osteoarthritis of the knee: a radiographic correlation

    International Nuclear Information System (INIS)

    Osteoarthritis (OA) is mixture of damage to a joint and reaction induced therefrom. Heterogeneity, slow change and no proper means of assessing pathology make it a difficult disease to study. Diagnosis can be made by radiography when OA is established. But subtle metabolic change without radiographic alteration can only be detected by bone scan. Present study was performed to assess metabolic profiles of OA of the knee with various radiographic and preradiographic changes using pinhole bone scan (PBS). PBS and radiography were taken at the same time or a few days apart. We used single-head gamma camera and a 4-mm pinhole collimator. Patients were 9 men and 19 women (30-74 yr with mean being 55). PBS was correlated with radiography in each case. Increased tracer uptake was seen in 111 lesions in 28 knees. Intensity was arbitrarily graded into Grade 0-2. The results were divided into group with radiographic change (n=85; Table) and group without (n=26). Generally, tracer uptake was much intense in the sclerotic and cystic form. In radiographically normal group pathological uptake occurred mostly in subchondral bone (n=17) and some in the femoral condyle (n=9) denoting that subchondral bone is the most vulnerable. PBS is sensitive indicator of metabolic alternations in various disease processes of OA in both radiographically normal and abnormal cases

  2. MR-guided bone biopsy performed with a new coaxial drill system

    International Nuclear Information System (INIS)

    Purpose: To describe the development and clinical evaluation of a new, hand-powered or alternatively motor-driven, MRI and CT compatible percutaneous bone biopsy system. Materials and Methods: A new coaxial drill system (Cook Europe A/S) was designed for percutaneous, MR-guided bone biopsies and powered either by hand or an optional motor (10-250 rotations/minute using 6 bar [88.2 PSI] compressed air). The system has been used in 23 patients. Fourteen procedures were performed in a 1.5 T MR scanner (Philips-Gyroscan ACS-NT) which has an attached C-arm (Philips-BV 212-Angio) in case fluoroscopy is required, and 9 procedures in a CT scanner (Siemens-Somatom Plus). Results: Driven by hand or by the pneumatic motor unit, the system achieved safe and accurate MR-guided access to all of the lesions and was even able to penetrate osteosclerotic lesions. MR- or CT-guided percutaneous biopsy yielded a correct diagnosis in all but 5 cases. No procedural complications occurred. Conclusion: MR-guided percutaneous bone biopsy performed with the new coaxial drill system was found to be safe and reliable, and suitable for obtaining histological specimens from skeletal lesions even when covered with thick cortical or sclerotic bone. (orig.)

  3. Osteoid osteoma of a metacarpal bone: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Chronopoulos Efstathios

    2008-08-01

    Full Text Available Abstract Introduction Osteoid osteoma is a benign tumor of the growing skeleton. It presents with pain, which is usually worse at night. The radiographic features consist of a central oval or round nidus surrounded first by a radiolucent area followed by another area of sclerotic bone. In the hand, osteoid osteoma is more commonly located in the phalanges and carpal bones. The metacarpals are the least common sites for osteoid osteoma. Case presentation We present a case of an osteoid osteoma of the left third metacarpal bone in a 36-year-old woman. The clinical and radiographic findings along with the surgical management of the lesion are presented. The pain disappeared immediately after the operation. At the 2-year follow-up, the patient was pain-free and there was no evidence of recurrence. Conclusion Physicians should be aware of the unusual presence and the atypical clinical presentation of this benign lesion in the metacarpal bones of the hand.

  4. Reaction rim growth in the systems MgO-SiO2 and CaO-MgO-SiO2: Diffusion pathways and the effect of water

    OpenAIRE

    Joachim, Bastian

    2011-01-01

    Growth of reaction rims and metamorphic coronas is recorded in many metamorphic rocks. Various parameters such as pressure, temperature, time, the chemical composition of a system and the presence of fluids may affect reaction rim growth. Laboratory experiments are the method of choice to derive transport mechanisms, reaction rates and component mobilities in polycrystalline rims as a function of these parameters. The major goal of this study is to derive component mobilities in rim growth ex...

  5. Bilateral primary xanthoma of the humeri with pathologic fractures: A case report

    OpenAIRE

    Ali, Sayed; Fedenko, Alex; Syed, Ali B; Matcuk, George; Patel, Dakshesh; Gottsegen, Chris; White, Eric

    2013-01-01

    Xanthomas are rare bone tumors that occur more often in the appendicular skeleton and typically appear radiographically benign, with a narrow zone of transition and a sclerotic rim. We report the case of a 57-year-old woman with hyperlipidemia presenting with bilateral shoulder pain after minor trauma. Radiographic and histopathologic investigation demonstrated intraosseous xanthoma with atypical features, including multifocality, a wide zone of transition and pathologic fractures-characteris...

  6. The C-terminal Cytosolic Region of Rim21 Senses Alterations in Plasma Membrane Lipid Composition: INSIGHTS INTO SENSING MECHANISMS FOR PLASMA MEMBRANE LIPID ASYMMETRY.

    Science.gov (United States)

    Nishino, Kanako; Obara, Keisuke; Kihara, Akio

    2015-12-25

    Yeast responds to alterations in plasma membrane lipid asymmetry and external alkalization via the sensor protein Rim21 in the Rim101 pathway. However, the sensing mechanism used by Rim21 remains unclear. Here, we found that the C-terminal cytosolic domain of Rim21 (Rim21C) fused with GFP was associated with the plasma membrane under normal conditions but dissociated upon alterations in lipid asymmetry or external alkalization. This indicates that Rim21C contains a sensor motif. Rim21C contains multiple clusters of charged residues. Among them, three consecutive Glu residues (EEE motif) were essential for Rim21 function and dissociation of Rim21C from the plasma membrane in response to changes in lipid asymmetry. In contrast, positively charged residues adjacent to the EEE motif were required for Rim21C to associate with the membrane. We therefore propose an "antenna hypothesis," in which Rim21C moves to or from the plasma membrane and functions as the sensing mechanism of Rim21. PMID:26527678

  7. Bone development.

    Science.gov (United States)

    Berendsen, Agnes D; Olsen, Bjorn R

    2015-11-01

    The development of the vertebrate skeleton reflects its evolutionary history. Cartilage formation came before biomineralization and a head skeleton evolved before the formation of axial and appendicular skeletal structures. This review describes the processes that result in endochondral and intramembranous ossification, the important roles of growth and transcription factors, and the consequences of mutations in some of the genes involved. Following a summary of the origin of cartilage, muscle, and tendon cell lineages in the axial skeleton, we discuss the role of muscle forces in the formation of skeletal architecture and assembly of musculoskeletal functional units. Finally, ontogenetic patterning of bones in response to mechanical loading is reviewed.This article is part of a Special Issue entitled "Muscle Bone Interactions". PMID:26453494

  8. Distribution of skeletal muscle involvement in distal myopathy with rimmed vacuoles

    International Nuclear Information System (INIS)

    Distribution of skeletal muscle involvement was studied clinically and by computed tomography (CT) in 6 cases (including 5 sporadic cases) with rimmed vacuolar distal myopathy. Although a predilection for the extensors in the lower leg was noted as stressed so far, there were certain cases without this selectivity. The thigh disclosed a selectivity that the flexors and adductors were severely affected while the m. quadriceps femoris was well preserved. The selectivity in the thigh was still found in the cases without selectivity in the lower leg. The neck flexors were also liable to be involved. In addition, CT revealed no compensatory hypertrophy of the specific muscles which was clearly shown in the thigh of distal muscular dystrophy (Miyoshi). The pattern of skeletal muscle involvement was thought to be a characteristic feature of distal myopathy with rimmed vacuoles. It was visualized very clearly and easily by CT of skeletal muscles although it could be noted to a certain degree by physical examination. (author)

  9. Asia/Pacific Rim renewable energy market assessments by the State of Hawaii

    International Nuclear Information System (INIS)

    The State of Hawaii has begun to encourage its economic growth and diversification by increasing the export of U.S. energy, environment, ocean, and information technologies. Hawaii's Strategic Technology Market Assessment and Development (STMAD) program promotes the transfer of U.S. technology into Asia and the Pacific Rim, locations having phenomenal growth potential and vast technological infrastructure demands. The STMAD program is managed by the State's Department of Business, Economic Development and Tourism (DBEDT). Under the auspices of STMAD, the Hawaii Natural Energy Institute (HNEI) of the University of Hawaii is assessing biomass energy resources of Asian and Pacific Rim countries to identify and investigate sustainable energy markets. This paper reviews the STMAD program and reports findings of renewable energy assessment performed by HNEI and DBEDT. (author)

  10. Development of SFR Research and Integration Management System (S-RIMS)

    International Nuclear Information System (INIS)

    Up to the present, the management of research and development (R and D) for a sodium cooled fast reactor (SFR) could be individually performed on each project without an organic relationship. However, a more systemic and effective integrated management of a project is required because the research and development environment is currently changing. Thus, we developed a Research and Integration Management System for SFR (S-RIMS) based on the enterprise project management (EPM) solution. The functional goals of the S-RIMS are as follows: 1. Provide data that show the progress and status of a project 2. Manage the design process and R and D products 3. Share the consistent design data between sub-projects

  11. Theoretical and experimental research of hammer forging process of RIM from AZ31 magnesium alloy

    Directory of Open Access Journals (Sweden)

    A. Gontarz

    2014-10-01

    Full Text Available The results of theoretical analysis and experimental tests of hammer forging process of rim part from AZ31 magnesium alloy are presented in this paper. On the basis of numerical simulation results, the analysis of limiting phenomena was made. These phenomena include: possibility of overlapping presence, not filling of die impression, overheating of material and cracks. The results of theoretical analysis provided the support for planning of experimental tests in industrial conditions. Forging tests were conducted in one of Polish forming plants, applying steam-air hammer of blow energy 63 kJ. On the basis of experimental verification, it was stated that it is possible to obtain rim forging from AZ31 alloy of assumed quality in the hammer forging process.

  12. Raman spectroscopic characterization of the core-rim structure in reaction bonded boron carbide ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Jannotti, Phillip; Subhash, Ghatu, E-mail: subhash@ufl.edu [Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611 (United States); Zheng, James Q.; Halls, Virginia [Program Executive Office—Soldier Protection and Individual Equipment, US Army, Fort Belvoir, Virginia 22060 (United States); Karandikar, Prashant G.; Salamone, S.; Aghajanian, Michael K. [M-Cubed Technologies, Inc., Newark, Delaware 19711 (United States)

    2015-01-26

    Raman spectroscopy was used to characterize the microstructure of reaction bonded boron carbide ceramics. Compositional and structural gradation in the silicon-doped boron carbide phase (rim), which develops around the parent boron carbide region (core) due to the reaction between silicon and boron carbide, was evaluated using changes in Raman peak position and intensity. Peak shifting and intensity variation from the core to the rim region was attributed to changes in the boron carbide crystal structure based on experimental Raman observations and ab initio calculations reported in literature. The results were consistent with compositional analysis determined by energy dispersive spectroscopy. The Raman analysis revealed the substitution of silicon atoms first into the linear 3-atom chain, and then into icosahedral units of the boron carbide structure. Thus, micro-Raman spectroscopy provided a non-destructive means of identifying the preferential positions of Si atoms in the boron carbide lattice.

  13. Dorsal acetabular rim radiographic view for evaluation of the canine hip

    International Nuclear Information System (INIS)

    A dorsal acetabular rim (DAR) radiographic view and positioning was devised to visualize the weight-bearing of the acetabulum of dogs for hip evaluation. The DAR view was performed on 250 dogs including 38 breeds. Both males and females were evaluated; ages ranged from six weeks to 11 years. The value of this technique is to evaluate the dorsal rim of the acetabulum for damage and secondary osteoarthritic changes, to correlate palpation of joint capsule laxity and crepitation with the radiographic appearance, to show acetabular filling, and to have an objective reproducible tool for determining whether a hip is normal, dysplastic or injured. This view is recommended as part of the routine procedure for hip examination

  14. Performance improvement of the RIMS device for application to FFDL system of the fast reactor

    International Nuclear Information System (INIS)

    In the fast reactors, it's crucial to install an effective failed fuel detection and location (FFDL) system for the purpose of protecting workers from radiation exposure and reducing radiation contamination. A new type of FFDL technique focused on the gas tagging method has been proposed by using resonance ionization mass spectrometry (RIMS) for the isotope analysis of the Ar cover gas. Though precise analysis of ppt level Kr and Xe in Ar needed is difficult because of the Ar+ and Ar2+ ions generated by the photoelectron, we could successfully decrease the signal amount of these ions by applying an electrode with a slit-type hole to permit ppt level detection of 80Kr without any obvious Ar2 interference. Some promising methods concerning effective utilization of laser light are also presented to increase the photoionization efficiency for further reliability improvement of RIMS in the FFDL system. (author)

  15. Star Formation in Bright Rimmed Clouds. I. Millimeter and Submillimeter Molecular Line Surveys

    OpenAIRE

    De Vries, Christopher H.; Narayanan, Gopal; Snell, Ronald L.

    2002-01-01

    We present the results of the first detailed millimeter and submillimeter molecular line survey of bright rimmed clouds, observed at FCRAO in the CO (J=1-0), C18O (J=1-0), HCO+ (J=1-0), H13CO+ (J=1-0), and N2H+ (J=1-0) transitions, and at the HHT in the CO (J=2-1), HCO+ (J=3-2), HCO+ (J=4-3), H13CO+ (J=3-2), and H13CO+ (J=4-3) molecular line transitions. The source list is composed of a selection of bright rimmed clouds from the catalog of such objects compiled by Sugitani e...

  16. Raman spectroscopic characterization of the core-rim structure in reaction bonded boron carbide ceramics

    International Nuclear Information System (INIS)

    Raman spectroscopy was used to characterize the microstructure of reaction bonded boron carbide ceramics. Compositional and structural gradation in the silicon-doped boron carbide phase (rim), which develops around the parent boron carbide region (core) due to the reaction between silicon and boron carbide, was evaluated using changes in Raman peak position and intensity. Peak shifting and intensity variation from the core to the rim region was attributed to changes in the boron carbide crystal structure based on experimental Raman observations and ab initio calculations reported in literature. The results were consistent with compositional analysis determined by energy dispersive spectroscopy. The Raman analysis revealed the substitution of silicon atoms first into the linear 3-atom chain, and then into icosahedral units of the boron carbide structure. Thus, micro-Raman spectroscopy provided a non-destructive means of identifying the preferential positions of Si atoms in the boron carbide lattice

  17. COL1A1 C-propeptide cleavage site mutation causes high bone mass, bone fragility and jaw lesions: a new cause of gnathodiaphyseal dysplasia?

    Science.gov (United States)

    McInerney-Leo, A M; Duncan, E L; Leo, P J; Gardiner, B; Bradbury, L A; Harris, J E; Clark, G R; Brown, M A; Zankl, A

    2015-07-01

    Gnathodiaphyseal dysplasia (GDD) is a rare autosomal dominant condition characterized by bone fragility, irregular bone mineral density (BMD) and fibro-osseous lesions in the skull and jaw. Mutations in Anoctamin-5 (ANO5) have been identified in some cases. We aimed to identify the causative mutation in a family with features of GDD but no mutation in ANO5, using whole exome capture and massive parallel sequencing (WES). WES of two affected individuals (a mother and son) and the mother's unaffected parents identified a mutation in the C-propeptide cleavage site of COL1A1. Similar mutations have been reported in individuals with osteogenesis imperfecta (OI) and paradoxically increased BMD. C-propeptide cleavage site mutations in COL1A1 may not only cause 'high bone mass OI', but also the clinical features of GDD, specifically irregular sclerotic BMD and fibro-osseous lesions in the skull and jaw. GDD patients negative for ANO5 mutations should be assessed for mutations in type I collagen C-propeptide cleavage sites. PMID:24891183

  18. Numerical calculation of bending fatigue life of thin-rim spur gears

    OpenAIRE

    Kramberger, Janez; Šraml, Matjaž; Potr?, Iztok; Flašker, Jože

    2012-01-01

    Mechanical elements subjected to cyclic loading have to be designed against fatigue. The main goal of the presented analysis was to determine the the bending fatigue life prediction of thin rim spur gears. The service life is divided into the initiation phase of the damage accumulation and the crack growth, resprcitively. The analysis has been performed usig FEM and BEM. The continuum mechanics approach is used for the prediction of the fatigue life initiation phase, where the basic fatigue m...

  19. Oxygen Isotope Measurements of a Rare Murchison Type A CAI and Its Rim

    Science.gov (United States)

    Matzel, J. E. P.; Simon, J. I.; Hutcheon, I. D.; Jacobsen, B.; Simon, S. B.; Grossman, L.

    2013-01-01

    Ca-, Al-rich inclusions (CAIs) from CV chondrites commonly show oxygen isotope heterogeneity among different mineral phases within individual inclusions reflecting the complex history of CAIs in both the solar nebula and/or parent bodies. The degree of isotopic exchange is typically mineral-specific, yielding O-16-rich spinel, hibonite and pyroxene and O-16-depleted melilite and anorthite. Recent work demonstrated large and systematic variations in oxygen isotope composition within the margin and Wark-Lovering rim of an Allende Type A CAI. These variations suggest that some CV CAIs formed from several oxygen reservoirs and may reflect transport between distinct regions of the solar nebula or varying gas composition near the proto-Sun. Oxygen isotope compositions of CAIs from other, less-altered chondrites show less intra-CAI variability and 16O-rich compositions. The record of intra-CAI oxygen isotope variability in CM chondrites, which commonly show evidence for low-temperature aqueous alteration, is less clear, in part because the most common CAIs found in CM chondrites are mineralogically simple (hibonite +/- spinel or spinel +/- pyroxene) and are composed of minerals less susceptible to O-isotopic exchange. No measurements of the oxygen isotope compositions of rims on CAIs in CM chondrites have been reported. Here, we present oxygen isotope data from a rare, Type A CAI from the Murchison meteorite, MUM-1. The data were collected from melilite, hibonite, perovskite and spinel in a traverse into the interior of the CAI and from pyroxene, melilite, anorthite, and spinel in the Wark-Lovering rim. Our objectives were to (1) document any evidence for intra-CAI oxygen isotope variability; (2) determine the isotopic composition of the rim minerals and compare their composition(s) to the CAI interior; and (3) compare the MUM-1 data to oxygen isotope zoning profiles measured from CAIs in other chondrites.

  20. Investigations on the performances of the electrical generator of a rim-driven marine current turbine”

    OpenAIRE

    DROUEN, Laurent; Charpentier, Jean-Frederic; SEMAIL, eric; Clenet, Stéphane

    2008-01-01

    In this paper, the electrical generator of a rim-driven horizontal-axis current turbine is modeled in detail. Its main characteristics and performances are evaluated (efficiency, mass, cost, etc). This generator is of permanent magnet direct-driven synchronous type and is connected to a variable speed power electronics drive. It is then compared to a more traditional technology (a pod generator) in terms of mass and cost for a common set of specification. In addition, due to the specific geo...

  1. Ciclamato de sódio e rim fetal Sodium cyclamate and fetal kidney

    OpenAIRE

    José Germano Ferraz de Arruda; Alex Tadeu Martins; Reinaldo Azoubel

    2003-01-01

    O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O ciclamato e a ciclohexilamina, seu principal metabólito, atravessam a barreira placentária em humanos e desse modo podem ser expostos ao feto. O rim de ratos pode ser afetado por elevadas doses de ciclamato de sódio. Estudos sobre ef...

  2. Determinants and structural development of FDI in Pacific-Rim developing countries

    OpenAIRE

    Agarwal, Jamuna Prasad

    1989-01-01

    The movements of foreign direct investment (FDI) in the recent past are marked by a relatively very high growth in the Pacific Rim (PR) countries (Australia, Brunei, China, Hongkong, Japan, Indonesia, Malaysia, Papua New Guinea, New Zealand, Philippines, Singapore, Taiwan, Thailand). The developing countries of this area were able to raise considerably their share of the total world outflows in the first half of this decade (Table Al) . In the following analysis an attempt is made to work out...

  3. PRAGMA-ENT: Exposing SDN Concepts to Domain Scientists in the Pacific Rim

    OpenAIRE

    Ichikawa, Kohei; Tsugawa, Mauricio; Haga, Jason; Yamanaka, Hiroaki; Liu, Te-Lung; Kido, Yoshiyuki; U-Chupala, Pongsakorn; Huang, Che; Nakasan, Chawanat; Chang, Jo-Yu; Ku, Li-Chi; Tsai, Whey-Fone; Date, Susumu; Shimojo, Shinji; Papadopoulos, Philip

    2015-01-01

    The Pacific Rim Application and Grid Middleware Assembly (PRAGMA) is an international community of researchers that actively collaborate to address problems and challenges of common interest in eScience. The PRAGMA Experimental Network Testbed (PRAGMA-ENT) was established with the goal of constructing an international software-defined network (SDN) testbed to offer the necessary networking support to the PRAGMA cyberinfrastructure. PRAGMA-ENT is isolated, and PRAGMA research...

  4. Development of a New Resilience Scale: The Resilience in Midlife Scale (RIM Scale)

    OpenAIRE

    Linda Ryan; Marie L. Caltabiano

    2009-01-01

    Resilience, the ability to maintain or regain positive levels of functioning despite adversity, is one of several strengths that can assist people in positive life adaptation. Midlife (35 - 60 years) is a period when individuals need to adapt to several major changes and challenges. However, no scale exists to measure resilience specifically in the midlife population. Therefore, this study develops a new scale to measure resilience in midlife. The RIM scale consists of 25 items, each self-rat...

  5. Abnormal increases of lysosomal cysteinine proteinases in rimmed vacuoles in the skeletal muscle.

    OpenAIRE

    Ii, K.; Hizawa, K; Nonaka, I.; Sugita, H.; Kominami, E; Katunuma, N.

    1986-01-01

    Skeletal muscle obtained from a patient with distal myopathy with rimmed vacuole formation (DMRV) was examined by a new direct labeled antibody enzyme method of immunohistochemistry. Abnormal increases of cathepsins B and H, capable of degrading the myofibrillar proteins, were demonstrated to be localized at the site of vacuoles and other intramyofibral portions and not to be associated with concomitant increases of their endogenous inhibitors. Autodigestion by these intramyofibral lysosomal ...

  6. Ultratrace analysis of long-lived radionuclides by resonance ionization mass spectrometry (RIMS)

    International Nuclear Information System (INIS)

    Radioisotope mass spectrometry for the determination of long-lived nuclides can be several orders of magnitude more sensitive than the conventional radiometric methods. The principle of RIMS consists of the vaporization of the radionuclide to be determined and to perform a multiple resonant excitation and ionization of the atoms by laser light. This is followed by mass selective detection of the ions by a time-of-flight mass spectrometer. Several applications are presented. (author)

  7. High-mass star formation within the bright-rimmed cloud SFO 79

    OpenAIRE

    Urquhart, J. S.; Thompson, M. A.; Morgan, L.K.; White, Glenn J.

    2004-01-01

    We report Radio Recombination Line (RRL) and continuum observations toward the IRAS point source 16362--4845, embedded within the Bright-Rimmed Cloud (BRC) SFO 79, a small molecular cloud lying at the edge of the HII region RCW 108. High resolution observations of the H92alpha hydrogen recombination line and of the continuum emission (3.6 and 6 cm) confirm the presence of a resolved Ultra Compact (UC) HII region embedded within the molecular cloud. The integrated radio fluxe...

  8. Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis

    OpenAIRE

    Bokuda Kota; Sugaya Keizo; Tamura Shunichiro; Miyamoto Kazuhito; Matsubara Shiro; Komori Takashi

    2012-01-01

    Abstract Background The autophagic vacuolar myopathies (AVM) are a group of inherited myopathies defined by the presence of autophagic vacuoles in pathological muscle specimens. AVM can be categorized into three groups: acid maltase deficiency, myopathies characterized by autophagic vacuoles with unique sarcolemmal features, and rimmed vacuolar myopathies (RVM). While the pathogeneses of these conditions are still being elucidated, some drugs (e.g., chloroquine, its analog, hydroxychloroquine...

  9. Distal myopathy with rimmed vacuoles: Report on clinical characteristics in 23 cases

    OpenAIRE

    Nalini A; Gayathri N; Dawn Rose

    2010-01-01

    Background: Distal myopathy with rimmed vacuoles (DMRV) is an autosomal recessive (AR) myopathy characterized clinically by the preferential involvement of the tibialis anterior and has been reported predominantly in the Japanese population. Materials and Methods: A case series of DMRV patients seen over a period of 3 years at a tertiary national referral center for neurological disorders in south India. Results: We describe the clinical characteristics, muscle magnetic resonance imaging...

  10. Ammonia observations of bright-rimmed clouds: establishing a sample of triggered protostars

    OpenAIRE

    Morgan, L.K.; Figura, C. C.; Urquhart, J. S.; Thompson, M. A.

    2010-01-01

    We observed 42 molecular condensations within previously identified bright-rimmed clouds in the ammonia rotational inversion lines NH3 (1,1), (2,2), (3,3) and (4,4) using the Green Bank Telescope in Green Bank, West Virginia. Using the relative peaks of the ammonia lines and their hyperfine satellites we have determined important parameters of these clouds, including rotational temperatures and column densities. These observations confirm the presence of dense gas towards ...

  11. Age Sequence in Small Clusters Associated with Bright-Rimmed Clouds

    OpenAIRE

    Ogura, Katsuo; Chauhan, Neelam; Pandey, Anil K.; Bhatt, Bhuwan C.; Ojha, Devendra; Itoh, Yoichi

    2006-01-01

    Bright-rimmed clouds (BRCs) found in H II regions are probable sites of triggered star formation due to compression by ionization/shock fronts, and it is hypothesized that star formation proceeds from the exciting star(s) side outward of the HII region ("small-scale sequential star formation"). In order to quantitatively testify this hypothesis we undertook BVIc photometry of four BRC aggregates. The amounts of interstellar extinction and reddening for each star have been es...

  12. The productive efficiency of ports: Lessons from the Pacific Rim Seaport's

    OpenAIRE

    Cheon, SangHyun

    2007-01-01

    This research is to evaluate whether and how global port reform efforts since the early 1990s strongly pursued in many Pacific Rim countries such as Australia, New Zealand, Singapore, China and many other ports in Latin America contribute to higher productivity. The research, as the basis of Mr. SangHyun Cheon's Ph.D. dissertation (the graduate student researcher conducting this research), theoretically aims to understand the ways port institutions, such as port ownership and corporate struct...

  13. Energy indicators series: analyzing the energy-related evidence of economic transition in the Pacific Rim

    International Nuclear Information System (INIS)

    In recent years, much attention has been focused upon the Asian Pacific countries as constituting an economic 'miracle' over the last two decades. Economic growth in the Pacific Rim has been higher than in any other area of the world. The rapid industrialization process and its impact on the economies of these countries, at both macro and micro levels, are discussed widely in the economic literature. Of particular interest are the fundamental structural changes these countries have experienced in their transition to industrialized economies. This instalment of the annual 'Energy indicators' series concentrates on Pacific Rim countries, namely Hong Kong, the Philippines, Singapore, South Korea, Taiwan and Thailand. Similar to other experiences, rapid economic growth in these countries has been accompanied by 'spectacular' growth in demand for energy. Therefore, this year's paper not only underlines certain trends in these six energy markets but also attempts to test the phenomenon 'threshold country', i.e., shifting from the developing to the industrialized world by using common indicators and methodologies. The analysis starts with a comparison of energy intensities. Section 2 provides an overview of the socio-economic and energy indicators of the Pacific Rim countries. Section 3 introduces a standard econometric model on the most dynamic consuming sector, namely transport. Section 4 presents the projections of consumption in this sector and discusses policy issues. Some concluding remarks in Section 6 complete the paper. (author)

  14. Radiolucent rim as a possible diagnostic aid for differentiating jaw lesions.

    Science.gov (United States)

    Mortazavi, Hamed; Baharvand, Maryam; Rahmani, Somayeh; Jafari, Soudeh; Parvaei, Parvin

    2015-12-01

    In this study, we formulate a new proposal that complements previous classifications in order to assist dental practitioners in performing a differential diagnosis based on patients' radiographs. We used general search engines and specialized databases such as Google Scholar, PubMed, PubMed Central, MedLine Plus, Science Direct, Scopus, and well-recognized textbooks to find relevant studies by using keywords such as "jaw disease," "jaw lesions," "radiolucent rim," "radiolucent border," and "radiolucent halo." More than 200 articles were found, of which 70 were broadly relevant to the topic. We ultimately included 50 articles that were closely related to the topic of interest. When the relevant data were compiled, the following eight lesions were identified as having a radiolucent rim: periapical cemento-osseous dysplasia, focal cemento-osseous dysplasia, florid cemento-osseous dysplasia, cemento-ossifying fibroma, osteoid osteoma, osteoblastoma, odontoma, and cementoblastoma. We propose a novel subcategory, jaw lesions with a radiolucent rim, which includes eight entities. The implementation of this new category can help improve the diagnoses that dental practitioners make based on patients' radiographs. PMID:26730374

  15. A Compact Array imaging survey of southern bright-rimmed clouds

    CERN Document Server

    Thompson, M A; White, G J

    2004-01-01

    We have carried out a radio-wavelength imaging survey of 45 bright-rimmed clouds (BRCs), using the Australia Telescope Compact Array to characterise the physical properties in their ionised boundary layers. We detected radio emission from a total of 25 clouds and using a combination of Digitised Sky Survey and mid-infrared MSX micron images classified the emission into that associated with the ionised cloud rims, that associated with embedded possible massive YSOs and that unlikely to be associated with the clouds at all. A total of 18 clouds display radio emission clearly associated with the cloud rim and we determine the ionising photon flux illuminating these clouds and the electron density and pressure of their ionised boundary layers. Using a global estimate for the interior molecular pressure of these clouds we show that the majority are likely to be in pressure equilibrium and hence are currently being shocked by photoionisation-induced shocks. We identify those clouds where the predicted ionising phot...

  16. Young Stellar Population of the Bright-Rimmed Clouds BRC 5, BRC 7 and BRC 39

    CERN Document Server

    Panwar, Neelam; Pandey, A K; Samal, M R; Ogura, K; Ojha, D K; Jose, J; Bhatt, B C

    2014-01-01

    Bright-rimmed clouds (BRCs), illuminated and shaped by nearby OB stars, are potential sites of recent/ongoing star formation. Here we present an optical and infrared photometric study of three BRCs: BRC 5, BRC 7 and BRC 39 to obtain a census of the young stellar population, thereby inferring the star formation scenario, in these regions. In each BRC, the Class I sources are found to be located mostly near the bright rim or inside the cloud, whereas the Class II sources are preferentially outside, with younger sources closer to the rim. This provides strong support to sequential star formation triggered by radiation driven implosion due to the UV radiation. Moreover, each BRC contains a small group of young stars being revealed at its head, as the next-generation stars. In particular, the young stars at the heads of BRC 5 and BRC 7 are found to be intermediate/high mass stars, which, under proper conditions, may themselves trigger further star birth, thereby propagating star formation out to long distances.

  17. Does Oxygen Isotopic Heterogeneity in Refractory Inclusions and Their Wark-Lovering Rims Record Nebular Repressing?

    Science.gov (United States)

    Simon, J. I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.

    2013-01-01

    Large systematic variations in O-isotopic compositions found within individual mineral layers of rims surrounding Ca-, Al-rich inclusions (CAIs) and at the margins of some CAIs imply formation from distinct environments [e.g., 1-3]. The O-isotope compositions of many CAIs preserve a record of the Solar nebula gas believed to initially be O-16-rich (delta O-17 less than or equal to -25%0) [4-5]. Data from a recent study of the compact Type A Allende CAI, A37, preserve a diffusion profile in the outermost 70 micrometers of the inclusion and show greater than 25%0 variations in delta O-17 within its 100 micrometer-thick Wark-Lovering rim (WL-rim) [3]. This and comparable heterogeneity measured in several other CAIs have been explained by isotopic mixing between the O-16-rich Solar reservoir and a second O-16-poor reservoir (probably nebular gas) with a planetary-like isotopic composition, e.g., [1,2,3,6]. However, there is mineralogical and isotopic evidence from the interiors of CAIs, in particular those from Allende, for parent body alteration. At issue is how to distinguish the record of secondary reprocessing in the nebula from that which occurred on the parent body. We have undertaken the task to study a range of CAI types with varying mineralogies, in part, to address this problem.

  18. Influence of stress and strain on dolomite rim growth: a comparative study

    Science.gov (United States)

    Helpa, V.; Rybacki, E.; Morales, L. F. G.; Dresen, G.

    2015-08-01

    Triaxial compression and torsion experiments were performed to investigate the influence of non-isostatic stress and strain on dolomite reaction rim growth using orientated natural calcite and magnesite single crystals at a temperature of 750 °C, 400 MPa confining pressure, stresses between 7 and 38 MPa, and test durations up to 171 h. Reaction products were composed of a polycrystalline magnesio-calcite layer, palisade-shaped dolomite, and granular dolomite grains. In all experiments, inelastic deformation was partitioned into calcite and reaction products, while magnesite remained undeformed. Calcite deformed by twinning and dislocation creep, where the activation of additional glide systems at high stress allowed high strain. Depending on grain size, magnesio-calcite deformed by diffusion creep and/or grain boundary sliding, twinning, and dislocation creep. Dolomite deformed mainly by diffusion creep, assisted by enhanced dislocation activity allowing Ca enrichment in the granular rim. A weak crystallographic preferred orientation of the reaction products was observed. In triaxial compression, dolomite rim growth was diffusion-controlled and showed no influence of axial stresses up to 38 MPa on the reaction kinetics. At high strain (>0.1), the magnesio-calcite layer is wider suggesting faster growth kinetics. This may be related to additional diffusion pathways provided by enhanced dislocation activity. At very high strain (>0.3-0.6), twisted samples showed a gradual decrease in layer thickness of dolomite and magnesio-calcite with increasing strain (-rate).

  19. The significance of evaluating the craniolateral acetabular rim for hip dysplasia

    International Nuclear Information System (INIS)

    The weight-bearing part of the canine hip is its dorsocraniolateral portion. On the radiograph the configuration of the craniolateral acetabular rim is important for evaluation of hip dysplasia. Changes in formation of this area should be differentiated from artefacts due to malpositioning. When the pelvis is tilted dorsally, the cranial acetabular rim is superimposed on the cranioventral acetabular contour and the acetabular roof. The craniolateral contour then seems to be missing. The contours of a ventrally tilted pelvis do not overlap, but it is difficult to discern the craniolateral rim. The reference points for Norberg-Olsson's measurements are difficult to choose in both cases and the angles may vary up to 10 degrees. A symmetrically positioned pelvis shows one point of reference for Norberg-Olsson's measurement where the cranial acetabular contour, the cranioventral margin and the acetabular roof intersect. Therefore poor positioning of the pelvis for radiographic evaluation of hip dysplasia should be avoided when using Norberg-Olsson's measurements

  20. Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases

    Directory of Open Access Journals (Sweden)

    Akira Toriihara

    2015-07-01

    Full Text Available Temporal bone chondroblastoma is an extremely rare benign bone tumor. We encountered two cases showing similar imaging findings on computed tomography (CT, magnetic resonance imaging (MRI, and dual-time-point 18F-fluorodeoxyglucose (18F-FDG positron emission tomography (PET/CT. In both cases, CT images revealed temporal bone defects and sclerotic changes around the tumor. Most parts of the tumor showed low signal intensity on T2- weighted MRI images and non-uniform enhancement on gadolinium contrast-enhanced T1-weighted images. No increase in signal intensity was noted in diffusion-weighted images. Dual-time-point PET/CT showed markedly elevated 18F-FDG uptake, which increased from the early to delayed phase. Nevertheless, immunohistochemical analysis of the resected tumor tissue revealed weak expression of glucose transporter-1 and hexokinase II in both tumors. Temporal bone tumors, showing markedly elevated 18F-FDG uptake, which increases from the early to delayed phase on PET/CT images, may be diagnosed as malignant bone tumors. Therefore, the differential diagnosis should include chondroblastoma in combination with its characteristic findings on CT and MRI.

  1. Gaucher disease: MR evaluation of bone marrow features during treatment with enzyme replacement

    International Nuclear Information System (INIS)

    Purpose: Enzyme replacement therapy (ERT) arrests and reverses the hematological and visceral symptoms of adult Gaucher disease, the most frequent lysosomal storage disorder. There are only a few studies available evaluating bone disease during ERT. The aim of this study was to investigate the features of bone marrow (bm) by magnetic resonance imaging (MRI) in these patients during ERT. Materials and Methods: MRI was performed prospectively in thirty adult type I Gaucher patients before and during ERT with a mean follow-up of 3 years. Spin-echo sequences (T1/T2) of the lower extremities were obtained and the reconversion (response) or lack of reconversion (non-response) to fatty marrow during treatment was analyzed. The morphological features of bm involvement, a homogeneous or non-homogeneous distribution of bm changes and focal bone lesions surrounded by a rim of reduced signal intensity (SI), were analyzed. Results: Infiltration of bm by Gaucher cells is characterized by a reduction of Sl on both T1- and T2-weighted sequences. Bone marrow responses were seen in 19 patients (63%) during treatment. Focal bone lesions, surrounded by a rim of reduced Sl, did not respond to ERT and correlated with a non-homogenous distribution of bone involvement and splenectomy. (orig.)

  2. Compositions of Diverse Noachian Lithologies at Marathon Valley, Endeavour Crater Rim, Mars

    Science.gov (United States)

    Mittlefehldt, David W.; Gellert, Ralf; Yen, Albert S.; Ming, Douglas W.; Van Bommel, Scott; Farrand, William H.; Arvidson, Raymond E.; Rice, James W., Jr.

    2015-01-01

    Mars Exploration Rover Opportunity has been exploring Meridiani Planum for 11+ years, and is presently investigating the geology of rim segments of 22 km diameter, Noachian-aged Endeavour crater. The Alpha Particle X-ray Spectrometer has determined the compositions of a pre-impact lithology and impact breccias representing ejecta from the crater. Opportunity is now investigating the head (higher elevation, western end) of Marathon Valley. This valley cuts eastward through the central portion of the Cape Tribulation rim segment and provides a window into the lower stratigraphic record of the rim. At the head of Marathon Valley is a shallow (few 10s of cm), ovoid depression approximately 27×36 m in size, named Spirit of Saint Louis, that is surrounded by approximately 20-30 cm wide zone of more reddish rocks (red zone). Opportunity has just entered a region of Marathon Valley that shows evidence for Fe-Mg smectite in Compact Reconnaissance Imaging Spectrometer for Mars spectra indicating areally extensive and distinct lithologic units and/or styles of aqueous alteration. Rocks at the head of Marathon Valley and within Spirit of Saint Louis are breccias (valley-head rocks). In some areas, layering inside Spirit of Saint Louis appears continuous with the rocks outside. The valley-head rocks are of similar, generally basaltic composition. The continuity in composition, texture and layering suggest the valley-head rocks are coeval breccias, likely from the Endeavour impact. These local breccias are similar in non-volatile-element composition to breccias investigated elsewhere on the rim. Rocks within the red zone are like those on either side in texture, but have higher Al, Si and Ge, and lower S, Mn, Fe, Ni and Zn as compared to rocks on either side. The valley-head rocks have higher S than most Endeavour rim breccias, while red zone rocks are like those latter breccias in S. Patches within the rocks outside Spirit of Saint Louis have higher Al, Si and Ge indicating red-zone-style alteration extended beyond the narrow red zone. Rocks on either side of the red zone and patches within it have the multispectral signature (determined by Panoramic Camera) of red hematite indicating an oxidizing environment. The red zone appears to be a thin alteration zone marking the border of Spirit of Saint Louis, but the origin of this morphologic feature remains obscure.

  3. Nat'l_Register, ContributingResources, The Rim Trail at Pipe Spring National Monument, Arizona (pisp_qrytrail)

    Data.gov (United States)

    National Park Service, Department of the Interior — This is an Arc/Info coverage consisting of 4 arcs representing the portion of The Rim Trail at Pipe Spring National Monument, Arizona that occurs within the...

  4. Relationships between Visual Field Sensitivity and Spectral Absorption Properties of the Neuroretinal Rim in Glaucoma by Multispectral Imaging

    OpenAIRE

    Denniss, Jonathan; Schiessl, Ingo; Nourrit, Vincent; Fenerty, Cecilia H; Gautam, Ramesh; Henson, David B

    2011-01-01

    In this study, multispectral imaging was used to show relationships between spectral absorption properties of the neuroretinal rim and visual field loss in glaucoma. Multispectral imaging may provide clinically useful information for assessment of glaucoma.

  5. Reaction rim growth in the system MgO-Al2O3-SiO2 under uniaxial stress

    Science.gov (United States)

    Götze, Lutz Christoph; Abart, Rainer; Rybacki, Erik; Keller, Lukas M.; Petrishcheva, Elena; Dresen, Georg

    2010-07-01

    We synthesize reaction rims between thermodynamically incompatible phases in the system MgO-Al2O3-SiO2 applying uniaxial load using a creep apparatus. Synthesis experiments are done in the MgO-SiO2 and in the MgO-Al2O3 subsystems at temperatures ranging from 1150 to 1350 °C imposing vertical stresses of 1.2 to 29 MPa at ambient pressure and under a constant flow of dry argon. Single crystals of synthetic and natural quartz and forsterite, synthetic periclase and synthetic corundum polycrystals are used as starting materials. We produce enstatite rims at forsterite-quartz contacts, enstatite-forsterite double rims at periclase-quartz contacts and spinel rims at periclase-corundum contacts. We find that rim growth under the “dry” conditions of our experiments is sluggish compared to what has been found previously in nominally “dry” piston cylinder experiments. We further observe that the nature of starting material, synthetic or natural, has a major influence on rim growth rates, where natural samples are more reactive than synthetic ones. At a given temperature the effect of stress variation is larger than what is anticipated from the modification of the thermodynamic driving force for reaction due to the storage of elastic strain energy in the reactant phases. We speculate that this may be due to modification of the physical properties of the polycrystals that constitute the reaction rims or by deformation under the imposed load. In our experiments rim growth is very sluggish at forsterite-quartz interfaces. Rim growth is more rapid at periclase-quartz contacts. The spinel rims that are produced at periclase-corundum interfaces show parabolic growth indicating that reaction rim growth is essentially diffusion controlled. From the analysis of time series done in the MgO-Al2O3 subsystem we derive effective diffusivities for the Al2O3 and the MgO components in a spinel polycrystal as D_{MgO} = 1.4 ± 0.2 \\cdot 10^{-15} m2/s and D_{Al_2O_3} = 3.7 ± 0.6 \\cdot 10^{-16} m2/s for T = 1350 °C and a vertical stress of 2.9 MPa.

  6. Development of high sensitive and reliable FFD and sodium leak detection technique for fast reactor using RIMS

    International Nuclear Information System (INIS)

    The high sensitive fuel failure and sodium leak detection technique for fast reactors has been developed using laser resonance ionization mass spectrometry (RIMS) method. The RIMS is suitable for the isotope analysis of the element of ultra trace level, since there is no increase of the background by interfering ion and isobaric interference except for measuring element, because the measuring element is selectively ionized. The RIMS was applied to measure the artificially blended xenon and krypton gas (tag gas) which is used for the pressurized steel capsule of in-pile creep rupture experiment in the experimental fast reactor Joyo. This system can measure the tag gas isotopic ratios of about 100 ? 102 ppb level and the measured results could identify tag gas. The RIMS system can detect stable xenon nuclides and 133Xe in the sample of cover gas which was stored in the stainless steel container during the fuel failure simulation test in Joyo. The result shows the applicability of the RIMS system for assuming the burn-up of the failed fuel subassembly by the ratio of stable and radioactive xenon isotopes. The RIMS is then applied to detect a small amount of sodium leaks from the fast reactor cooling system. In case of detecting sodium isotopes using RIMS, the aerodynamic lens was newly introduced, which can transfer aerosols at atmospheric pressure into a vacuum chamber while increasing the aerosol density at the same time. We performed the experiments using stable isotope 23Na to evaluate the detection sensitivity of the prototype system. The preliminary test results showed that prototype system could easily detect sodium aerosol of 2.7 ppt, of which sensitivity is 400 times higher than the conventional sodium leak detectors currently used. The RIMS system is expected to be a promising innovative instrumentation system not only for Monju, but also for the future sodium cooled fast reactors. (author)

  7. A Novel Mutation of the GNE Gene in Distal Myopathy with Rimmed Vacuoles: A Case with Inflammation

    OpenAIRE

    Tanboon, Jantima; Rongsa, Kanjana; Pithukpakorn, Manop; Boonyapisit, Kanokwan; Limwongse, Chanin; Sangruchi, Tumtip

    2014-01-01

    Distal myopathy with rimmed vacuoles (DMRV) is an autosomal recessive or sporadic early adult-onset myopathy caused by mutations in the UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase (GNE) gene. Characteristic pathologic features of DMRV are rimmed vacuoles on muscle biopsy and tubulofilamentous inclusion in ultrastructural study. Presence of inflammation in DMRV is unusual. We report a sporadic case of DMRV in a 40-year-old Thai man who presented with slowly progressive d...

  8. Ossificans myositis: inflammatory changes and contrast enhancement of adjacent bone shown by MR imaging; Myosite ossifiante circonscrite: remaniements osseux deceles en IRM

    Energy Technology Data Exchange (ETDEWEB)

    David, H.; Jolles, E.; Le Friant, G.; Silvestre, A.; Sarrazin, J.L.; Gordoliani, Y.S. [Hopital des Armees du Val-de-Grace, 75 - Paris (France)

    1995-07-01

    The authors report a case of ossificans myositis, in which magnetic resonance imaging (MRI) showed inflammatory changes of the adjacent bone. T 1 weighted fat saturation sequence with gadolinium injection showed enhancement of medullary and cortical bone. This potentially mistaking pattern must be known, to avoid mis diagnosing with malignant osseous tumor, specially before achievement of the characteristic pattern of zonal maturation and its calcified rim. (authors). 15 refs., 6 figs.

  9. Osteoporosis: The Bone Thief

    Science.gov (United States)

    ... of this makes your bones weaker. Who Has Osteoporosis? Ten million Americans have osteoporosis. They are mostly ... a bone. What Can I Do For My Osteoporosis? Treating osteoporosis means stopping the bone loss and ...

  10. Malignant bone tumors

    International Nuclear Information System (INIS)

    Clinicoroentgenologic semiotics of malignant bone tumors as well as metastatic bone tumors are presented. Diagnosis of malignant and metastatic bone tumors should be always complex, representing a result of cooperation of a physician, roentgenologist, pathoanatomist

  11. Subperiosteal ganglion associated with Paget's disease of bone

    International Nuclear Information System (INIS)

    Tumoral lesions related to Paget's disease may be classified as malignant, benign or pseudotumoral. While sarcomatous degeneration is the most feared complication, awareness of benign and pseudotumoral lesions is essential for assisting in accurate histological interpretation of the biopsy sample, which may avoid unnecessary repeat biopsies. We present the first case of a juxta-articular subperiosteal ganglion associated with Paget's disease, with classic imaging characteristics, especially on CT examination. The well-defined soft tissue mass at the medial aspect of the obturator rim, adjacent to a small fracture in pagetic quadrilateral plate, showed an ossified rim and internal gas lucencies, these being the hallmarks of a juxta-articular subperiosteal ganglion. On MRI, the lesion was of intermediate signal intensity on T1-weighted sequences, increased signal intensity on T2-weighted sequences, with rim enhancement after gadolinium contrast injection and preservation of fatty marrow signal of the underlying pagetic bone. Identification of the entity avoided an unnecessary biopsy or surgical intervention. (orig.)

  12. Anorexia Nervosa and Bone

    OpenAIRE

    Misra, Madhusmita; Klibanski, Anne

    2014-01-01

    Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone mass, impaired bone structure and reduced bone strength, all of which contribute to increased fracture risk., Adolescents with AN have decreased rates of bone accrual compared with normal-weight controls, raising addition concerns of suboptimal peak bone mass and future bone health in this age group. Changes in lean mass and compartmental fat depots, hormonal alterations secondary to nutritional factors...

  13. The Enigmatic Bench Unit of Endeavour Crater Rim in Meridiani Planum, Mars

    Science.gov (United States)

    Ruff, S. W.

    2013-12-01

    For the first 2680 sols of its mission, the Mars Exploration Rover Opportunity traversed across essentially the same rocks: sulfur-rich sandstones known as the Burns formation. On August 8, 2011 Opportunity completed a ~21 km traverse from Victoria crater to the rim of the ~22 km diameter Endeavour crater where it crossed a slightly raised smooth bench unit that surrounds an interior core of higher standing and more rugged terrain on a rim segment named Cape York. As recognized by its distinctive morphologic character evident in orbital images, the inward sloping bench feature is found associated with portions of other segments of the discontinuous raised rim of Endeavour crater. Viewed by Opportunity, it appears as platy, fractured, relatively light-toned outcrop that is fine-grained, lacks hematite concretions and in places hosts veins of Ca- and S-rich composition, likely due to precipitation of gypsum in fractures that cut the bench unit (1). The bench outcrop target named Grasberg included a grind using the Rock Abrasion Tool (RAT) to obtain a cleaner surface for the Alpha Particle X-ray Spectrometer chemistry measurement compared with the initially investigated target named Deadwood. In addition to its greater strength than Burns formation as determined by the RAT grind operation, Grasberg and other examples of the bench unit have lower S, higher Cl and other elemental characteristics that depart from typical Burns formation. Thus the 'Grasberg unit' clearly represents a distinct rock type compared to the Meridiani plains. A second unit makes up the exposed core of the Cape York rim segment. Known as Shoemaker formation, it is composed of breccias that are recognized as a suevite deposit produced from the Endeavour impact event (1). The Shoemaker formation appears to be onlapped by the Grasberg unit with Burns formation onlapping it (1). However, a well-exposed section observed in a wedge-shaped fracture known as Whim Creek on the northeast portion of the Cape York bench clearly presents Grasberg rocks above Burns rocks. Erosion of a plunging synclinal form could explain this apparent inverted relationship, or it reveals that the Grasberg unit is younger than Burns formation. But this latter interpretation implies that Grasberg rocks, which have been observed only at the Endeavour rim, have been stripped off of Burns formation everywhere else. The Grasberg bench unit has recently been encountered in an isthmus setting between two low knobs of presumed Shoemaker formation called Nobbys Head and Sutherland Point just south of Cape York. The isthmus also presents Grasberg as topographically elevated above the Burns formation rocks. Despite its broad, smooth exposure, no remnants of Burns formation have been found on top of Grasberg at this location or anywhere on the Cape York bench. So the stratigraphic relationship between Grasberg and Burns rocks remains enigmatic. At the time of writing, Opportunity is at the edge of Solander Point, another bench feature on the northern tip of a rim segment known as Cape Tribulation. The erosional expression of this example appears different from those examined previously and perhaps offers the best chance to understand stratigraphic relationships. 1. S. W. Squyres et al., Ancient impact and aqueous processes at Endeavour Crater, Mars. Science 336, 570 (2012).

  14. Bone and bone marrow involvement in sarcoidosis.

    Science.gov (United States)

    Yachoui, Ralph; Parker, Brian J; Nguyen, Thanhcuong T

    2015-11-01

    Bone and bone marrow involvement in sarcoidosis have been infrequently reported. We aimed to describe the clinical features, radiological descriptions, pathological examinations, and outcomes of three patients with osseous sarcoidosis and one patient with bone marrow sarcoidosis seen at our institution. Our case series included fluorodeoxyglucose positron emission tomography descriptions in assessing the whole-body extent of sarcoidosis. In the era of advanced imaging, large bone and axial skeleton sarcoidosis lesions are more common than previously reported. PMID:26248533

  15. RIMS: An Integrated Mapping and Analysis System with Applications to Earth Sciences and Hydrology

    Science.gov (United States)

    Proussevitch, A. A.; Glidden, S.; Shiklomanov, A. I.; Lammers, R. B.

    2011-12-01

    A web-based information and computational system for analysis of spatially distributed Earth system, climate, and hydrologic data have been developed. The System allows visualization, data exploration, querying, manipulation and arbitrary calculations with any loaded gridded or vector polygon dataset. The system's acronym, RIMS, stands for its core functionality as a Rapid Integrated Mapping System. The system can be deployed for a Global scale projects as well as for regional hydrology and climatology studies. In particular, the Water Systems Analysis Group of the University of New Hampshire developed the global and regional (Northern Eurasia, pan-Arctic) versions of the system with different map projections and specific data. The system has demonstrated its potential for applications in other fields of Earth sciences and education. The key Web server/client components of the framework include (a) a visualization engine built on Open Source libraries (GDAL, PROJ.4, etc.) that are utilized in a MapServer; (b) multi-level data querying tools built on XML server-client communication protocols that allow downloading map data on-the-fly to a client web browser; and (c) data manipulation and grid cell level calculation tools that mimic desktop GIS software functionality via a web interface. Server side data management of the system is designed around a simple database of dataset metadata facilitating mounting of new data to the system and maintaining existing data in an easy manner. RIMS contains "built-in" river network data that allows for query of upstream areas on-demand which can be used for spatial data aggregation and analysis of sub-basin areas. RIMS is an ongoing effort and currently being used to serve a number of websites hosting a suite of hydrologic, environmental and other GIS data.

  16. Anterior versus posterior, and rim-rent rotator cuff tears: prevalence and MR sensitivity

    International Nuclear Information System (INIS)

    Purpose. To determine the relative distribution of the locations of rotator cuff tears, and the sensitivity of anterior versus posterior tears on MR images. Patients and methods. We identified 110 consecutive patients who had a shoulder MR and either a partial-thickness or a small full-thickness rotator cuff tear diagnosed at arthroscopy. MR sensitivity and patient age were compared between patients with tears in the anterior and posterior halves of the cuff. In addition, in patients with partial tears less than 2 cm in diameter, an age comparison between those with tears in the critical zone and those with articular surface tears adjacent to the bony insertion (rim-rent tear) was performed. Results. The tear was centered in the anterior half of the rotator cuff in 79% of the patients younger than 36 years old, and in 89% of the patients 36 years old and over. The average age of the patients with tears in the anterior half (44 years) was not significantly different from the average age of those with posterior tears (40 years). The sensitivity of MR for anterior tears was 0.69, and for posterior tears it was 0.56. Five of the nine rim-rent tears (0.56) were interpreted correctly on the original MR report; two of the other tears were misinterpreted as intratendinous fluid but were diagnosable in retrospect. Conclusion. Even in patients less than 36 years old, most partial and small full-thickness rotator cuff tears are centered in the anterior half of the supraspinatus. Although our figure for MR sensitivity for these tears is lower than in recent articles, we found no significant difference between the sensitivity of MR for diagnosing posterior tears versus tears in the anterior half of the supraspinatus tendon. Rim-rent tears can be mistaken for intratendinous signal, and should be carefully looked for in younger patients with shoulder pain. (orig.)

  17. Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Bokuda Kota

    2012-11-01

    Full Text Available Abstract Background The autophagic vacuolar myopathies (AVM are a group of inherited myopathies defined by the presence of autophagic vacuoles in pathological muscle specimens. AVM can be categorized into three groups: acid maltase deficiency, myopathies characterized by autophagic vacuoles with unique sarcolemmal features, and rimmed vacuolar myopathies (RVM. While the pathogeneses of these conditions are still being elucidated, some drugs (e.g., chloroquine, its analog, hydroxychloroquine, and colchicine can also cause AVM. Minocycline is a disease-modifying anti-rheumatic drug that may be used in the treatment of rheumatoid arthritis (RA. Here, we describe the first case of minocycline-associated AVM with rimmed vacuole formation. Case presentation A 75-year-old woman suffering from RA has been continuously treated with minocycline (200 mg/day for the past 7 years. During this time, she developed a myopathy that predominantly affected her lower limbs. Histological studies of biopsied muscle revealed scattered atrophic myofibers with rimmed vacuoles that contained pigment granules. Histochemical staining revealed that the pigment comprised both iron and melanin, which is consistent with type II minocycline-induced cutaneous pigmentation. Under electron microscopy, autophagic vacuoles were consistently observed in association with numerous collections of pigment granules. Conclusions This is the first report of minocycline-induced pigmentation in skeletal muscle. The strong association between autophagic vacuoles and the accumulation of minocycline-induced pigments suggest that long-term minocycline treatment induced pigment accumulation, leading to elevation of autophagic activity and RVM. It might also be possible that minocycline directly activated autophagy, as the observed pigments are known to form complexes containing minocycline and/or its metabolites. As long-term minocycline treatment is expected to be used more widely in the future, we must draw attention to this adverse effect.

  18. Forward modeling of radio imaging (RIM) data with the Comsol RF module

    Science.gov (United States)

    Li, Yongxing; Smith, Richard S.

    2015-12-01

    Radio imaging method (RIM) is an electromagnetic (EM) tomographic method, which can be applied to image the electrical properties (principally the conductivity) in the plane defined by two boreholes. RIM employs the EM waves at radio frequencies between 100 kHz and 10 MHz, and the manner that these waves propagate around subsurface ore bodies has not been studied thoroughly. We studied the wave propagation using the finite element modeling (FEM) algorithm as implemented in the Comsol RF module. An appropriate element size is quantified by comparing the Comsol modeling results of 6 types of element sizes at 4 frequencies with the analytical solution in the homogeneous whole space. The FEM model data with 5 elements per wavelength have errors less than 5%; 7-8 elements per wavelength provide the errors around 1%; when there are 10 elements per wavelength, the errors are less than 1%. Comparison studies for more complicated models with anomalous conductivity structures show that the Comsol modeling results are consistent with results derived from analytical solutions, finite-difference time-domain methods and integral equations. To illustrate the flexibility of the Comsol method for RIM modeling, we provide an example with two moderately conductive bodies between boreholes. Receiver profiles and a relative variation map show that when the conductive bodies are two wavelengths away from the source, the EM wave attenuation and reflection by the conductive bodies can be observed. The amplitude tomography of the model data reveals that with the SIRT algorithm, the location of the conductive anomalies can be reconstructed successfully, although, some limitations exist such as low resolution, incorrect conductivity estimation, and some artifacts. From our work, we conclude that Comsol modeling is helpful to study radio wave propagation and imaging methods.

  19. Bone development

    DEFF Research Database (Denmark)

    Tatara, M.R.; Tygesen, Malin Plumhoff; Sawa-Wojtanowicz, B.; Krupski, W.; Majcher, P.; Harrison, Adrian Paul

    The objective of this study was to determine the long-term effect of alpha-ketoglutarate (AKG) administration during early neonatal life on skeletal development and function, with emphasis on bone exposed to regular stress and used to serve for systemic changes monitoring, the rib. Shropshire ram...... 146 days of life and five left and right ribs (fourth to eighth) were removed for analysis. The influence of AKG on skeletal system development was evaluated in relation to both geometrical and mechanical properties, as well as quantitative computed tomography (QCT). No significant differences between...... has a long-term effect on skeletal development when given early in neonatal life, and that changes in rib properties serve to improve chest mechanics and functioning in young animals. Moreover, neonatal administration of AKG may be considered as an effective factor enhancing proper development and...

  20. Paget's sarcoma of bone

    International Nuclear Information System (INIS)

    The most sinister complication of Paget's disease is malignant degeneration. The true etiology of Paget's disease remains unproven and unknown. The relative incidence of sarcoma ranges from 0.9% to 20% depending upon the population source. The anatomical distribution of lesions is similar to that of uncomplicated Paget's disease except for the high incidence in the humerus and rare occurrence in the spine. Approximately 50% of the lesions histologically represent osteosarcomas, with fibrosarcoma, fibrous histiocytoma, chondrosarcoma and giant cell tumor rarely occurring. The radiographic presentation is most commonly lytic, but sclerotic and mixed patterns occur. Cortical destruction and soft tissue mass are the cardinal radiographic signs. Malignant periosteal response is seldom found associated with Paget's sarcoma. The most common sites are femur, humerus, pelvis, skull and tibia. The prognosis is fatal at a very rapid rate. There are but a few isolated cases of long-term survival reported. (orig.)

  1. Evaluation of radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT

    International Nuclear Information System (INIS)

    The aim of the study was to retrospectively evaluate radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT and determine their roles on the evaluation of therapy response. We retrospectively evaluated radiographic and metabolic characteristics of bone metastases in 30 patients who were referred for the evaluation of response to systemic therapy with 18FDG-PET/CT. All patients underwent integrated 18FDG-PET/CT before and after treatment. The baseline radiographic patterns of the target lesions in responders group were lytic, sclerotic, mixed and CT negative; after treatment the radiographic patterns of all target lesions changed to a sclerotic pattern and attenuation increased (p = 0.012) and metabolic activity decreased (p = 0.012). A correlation was found between decreasing metabolic activity and increasing attenuation of the target lesions (r = ?0.55) (p = 0.026). However, in nonresponders group, the baseline radiologic patterns of the target lesions were lytic, blastic, mixed and CT negative; after treatment all lytic target lesions remained the same and one CT negative lesion turned to lytic pattern and the attenuation of the target lesions decreased (p ± 0.12) and metabolic activity increased (p = 0.012). A correlation was found between increasing metabolic activity and decreasing attenuation (r = ?0.65) (p = 0.032). An exception of this rule was seen in baseline blastic metastases which progressed with increasing in size, metabolic activity and attenuation. This study shows that the metabolic activity of lesions is a more reliable parameter than the radiographic patterns for the evaluation of therapy response

  2. Evaluation of radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT

    Science.gov (United States)

    Gunalp, Bengul; Oner, Ali Ozan; Ince, Semra; Alagoz, Engin; Ayan, Asl?; Arslan, Nuri

    2015-01-01

    Background. The aim of the study was to retrospectively evaluate radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT and determine their roles on the evaluation of therapy response. Patients and methods. We retrospectively evaluated radiographic and metabolic characteristics of bone metastases in 30 patients who were referred for the evaluation of response to systemic therapy with 18FDG-PET/CT. All patients underwent integrated 18FDG-PET/CT before and after treatment. Results. The baseline radiographic patterns of the target lesions in responders group were lytic, sclerotic, mixed and CT negative; after treatment the radiographic patterns of all target lesions changed to a sclerotic pattern and attenuation increased (p = 0.012) and metabolic activity decreased (p = 0.012). A correlation was found between decreasing metabolic activity and increasing attenuation of the target lesions (r = ?0.55) (p = 0.026). However, in nonresponders group, the baseline radiologic patterns of the target lesions were lytic, blastic, mixed and CT negative; after treatment all lytic target lesions remained the same and one CT negative lesion turned to lytic pattern and the attenuation of the target lesions decreased (p ± 0.12) and metabolic activity increased (p = 0.012). A correlation was found between increasing metabolic activity and decreasing attenuation (r = ?0.65) (p = 0.032). An exception of this rule was seen in baseline blastic metastases which progressed with increasing in size, metabolic activity and attenuation. Conclusions. This study shows that the metabolic activity of lesions is a more reliable parameter than the radiographic patterns for the evaluation of therapy response. PMID:26029021

  3. Technical Efficiency and Port Competition: Revisiting the Bohai Economic Rim, China

    Directory of Open Access Journals (Sweden)

    Grace Wang

    2012-12-01

    Full Text Available The Bohai Economic Rim plays an important role in supporting China’s economic growth. For this research, we selected nine main ports in the region to study whether intra-port competition or corporatization would improve efficiency. Using a panel fixed effect model and stochastic frontier model, we found that the technical efficiency of selected ports is significantly influenced by the time of the initial public offering than by regional competition. The results are supportive and encouraging for policy makers to move toward the decentralized port governance in China.

  4. The rim effect and other high-burnup modeling for NRC fuel performance codes

    International Nuclear Information System (INIS)

    The U.S. Nuclear Regulatory Commission (NRC) has recently initiated a new program to review data on the material properties of fuel and cladding at high burnup levels. The objective of this program is to update NRC fuel performance models within fuel performance codes to improve their predictive capability to rod-average burnup levels of 60 GWd/MTM. Models being reviewed for improvement at the higher burnup levels are fission gas release, fuel swelling, gap conductance, fuel thermal conductivity, pellet rim structure, radial power distribution, cladding corrosion/hydriding, and cladding mechanical properties

  5. Avaliação lectino-histoquímica de fígado e rim de ovinos com fotossensibilização causada por Brachiaria decumbens

    Directory of Open Access Journals (Sweden)

    Samay Z.R. Costa

    2013-08-01

    Full Text Available Embora sejam as forrageiras mais importantes para a pecuária de corte (bovinocultura de corte no Brasil, em certas épocas ou condições, Brachiaria spp. podem ser tóxicas e causar surtos de fotossensibilização hepatógena que determinam significativas perdas econômicas. Animais que se alimentam em pastos de Brachiaria spp. comumente apresentam macrófagos espumosos isolados ou agrupados, além de cristais no interior de ductos biliares. Saponinas esteroidais têm sido identificadas nestes cristais e são responsabilizadas por lesar o fígado levando ao acúmulo de filoeritrina. Por vezes, imagens negativas desses cristais podem estar presentes no citoplasma de macrófagos espumosos. A patogênese de formação e o tipo de material armazenado nas células espumosas ainda são desconhecidos. A técnica de lectino-histoquímica visa auxiliar na detecção desses macrófagos e, consequentemente, no diagnóstico, além de identificar quais os resíduos de açúcares específicos que estão presentes no citoplasma das células espumosas. Assim, este trabalho teve por objetivo identificar quais lectinas são mais indicadas na detecção de saponinas esteroidais no fígado e rim de ovinos com fotossensibilização causada por Brachiaria decumbens. Fragmentos de fígado e rim de quinze ovinos, de ambos os sexos e idade variável, oriundos de Conceição do Mato Dentro, Minas Gerais, e um ovino mantido em pastagem livre de Brachiaria spp. foram avaliados pela técnica de lectino-histoquímica. Quatorze lectinas foram utilizadas (Con-A, DBA, SBA, PNA, SJA, RCA-I, UEA-I, WGA, SWGA, GSL, PSA, PHA-L, PHA-E e LCA. Verificou-se que, no fígado de ovinos com fotossensibilização provocada pela ingestão de Brachiaria decumbens, a lectina PNA apresentou especificidade e acentuada reatividade aos macrófagos espumosos, bem como especificidade e leve reatividade aos hepatócitos; a lectina WGA teve especificidade e moderada reatividade aos macrófagos espumosos do fígado e especificidade e leve reatividade aos hepatócitos; e as lectinas SBA, GSL e LCA apresentaram especificidade e moderada reatividade aos macrófagos espumosos, entretanto, não foram específicas para hepatócitos. No rim dos ovinos, a lectina PNA foi a que apresentou maior reatividade. Avaliações lectino-histoquímicas ainda não haviam sido realizadas em fígado e rim de ovinos com fotossensibilização provocada por Brachiaria spp.

  6. Ultratrace determination of the long-lived isotope 41Ca by narrowband CW-RIMS

    International Nuclear Information System (INIS)

    Determination of odd isotopes with multi-step RIMS is usually hampered by the hyperfine structure arising from a non zero nuclear spin. The splitting of the transition strength leads to a reduced ionization efficiency and large uncertainties in the determination of isotope ratios. We present a technique to overcome these drawbacks by appropriate use of optical pumping. Applying this technique, first isotopic ratio measurements on synthetic 41Ca-samples could be accomplished using double-resonance three photon ionization in a collimated atomic beam combined with a quadrupole mass spectrometer

  7. Radio continuum and molecular line observations of four bright-rimmed clouds

    OpenAIRE

    Urquhart, J. S.; Thompson, M. A.; Morgan, L.K.; White, Glenn J.

    2006-01-01

    Aims.To search for evidence of triggered star formation within four bright-rimmed clouds, SFO 58, SFO 68, SFO 75 and SFO 76. Methods: .We present the results of radio continuum and molecular line observations conducted using the Mopra millimetre-wave telescope and Australia Telescope Compact Array. We use the J=1{-}0 transitions of 12CO, 13CO and C18O to trace the distribution of molecular material and to study its kinematics. The radio continuum data is used to trace the distribution of t...

  8. Effects of Magnetic Field and FUV Radiation on the Structures of Bright-rimmed Clouds

    OpenAIRE

    Motoyama, Kazutaka; Umemoto, Tomofumi; Shang, Hsien; Hasegawa, Tatsuhiko

    2013-01-01

    The bright-rimmed cloud SFO 22 was observed with the 45 m telescope of Nobeyama Radio Observatory in the ^{12}CO (J = 1-0), ^{13}CO (J = 1-0), and C^{18}O (J = 1-0) lines, where well-developed head-tail structure and small line widths were found. Such features were predicted by radiation-driven implosion models, suggesting that SFO 22 may be in a quasi-stationary equilibrium state. We compare the observed properties with those from numerical models of a photo-evaporating clo...

  9. Collapse and expansion in the bright-rimmed cloud SFO 11NE

    OpenAIRE

    Thompson, M. A.; White, G. J.

    2004-01-01

    We report the results of a search for the double-peaked blue-skewed infall signature in the bright-rimmed cloud core SFO 11NE SMM1. Observations of the optically thick HCO$^{+}$ and optically thin H$^{13}$CO$^{+}$ J=3--2 lines reveal that there is indeed a characteristic double-peaked line profile, but skewed to the red rather than the blue. Modelling of the dust continuum emission and line profiles show that the motions within SFO 11NE SMM1 are consistent with a collapsing ...

  10. Numerical Simulation of Stresses in Thin-rimmed Spur Gears with Keyway

    OpenAIRE

    B. Br?žek; Leidich, E.

    2003-01-01

    This paper contains an investigation of the key on a stress distribution in a thin-rimmed spur gear. A stress analysis was carried out by means of the Finite Element Method (FEM). The 2D-FE analysis has helped to find the influence of turning the gearing towards the keyway on the stress in the loaded root of the tooth and in the keyway. 2D and 3D numerical analysis has been used to find mutual influence of every single notch (root of tooth and keyway), influence of thickness of the hub, lengt...

  11. A bright-rimmed cloud sculpted by the H ii region Sh2-48

    OpenAIRE

    Ortega, M. E.; Paron, S.; Giacani, E.; Rubio, M.; Dubner, G.

    2013-01-01

    To characterize a bright-rimmed cloud embedded in the HII region Sh2-48 searching for evidence of triggered star formation. We carried out observations towards a region of 2'x2' centered at RA=18h 22m 11.39s, dec.=-14deg 35m 24.81s (J2000) using the Atacama Submillimeter Telescope Experiment (ASTE; Chile) in the 12CO J=3-2,13CO J=3-2, HCO+ J=4-3, and CS J=7-6 lines with an angular resolution of about 22". We also present radio continuum observations at 5 GHz carried out with...

  12. Improvements in RIMS Isotopic Precision: Application to in situ atom-limited analyses

    International Nuclear Information System (INIS)

    Resonance ionization mass spectrometry offers high sensitivity and elemental selectivity in microanalysis, but the isotopic precision attainable by this technique has been limited. Here we report instrumental modifications to improve the precision of RIMS isotope ratio measurements. Special attention must be paid to eliminating pulse-to-pulse variations in the time-of-flight mass spectrometer through which the photoions travel, and resonant excitation schemes must be chosen such that the resonance transitions can substantially power-broadened to cover the isotope shifts. We report resonance ionization measurements of chromium isotope ratios with statistics-limited precision better than 1%.

  13. The stellar population and complex structure of the bright-rimmed cloud IC 1396N

    OpenAIRE

    Beltran, M. T.; Massi, F.; Lopez, R.; Girart, J. M.; Estalella, R.

    2009-01-01

    Context. IC 1396N is a bright-rimmed cloud associated with an intermediate-mass star-forming region, where a number of Herbig-Haro objects, H2 jet-like features, CO molecular outflows, and millimeter compact sources have been observed. Aims. To study in detail the complex structure of the IC 1396N core and the molecular outflows detected in the region and to reveal the presence of additional YSOs inside this globule. Methods. We carried out a deep survey of the IC 1396N regi...

  14. Improvements in RIMS isotope precision: applications to in situ atom-limited isotopic analysis

    International Nuclear Information System (INIS)

    Resonance ionization mass spectrometry offers high sensitivity and elemental selectivity in microanalysis, but the isotopic precision attainable by this technique has been limited. Here we report instrumental modifications to improve the precision of RIMS isotope ratio measurements. Special attention must be paid to eliminating pulse-to-pulse variations in the time-of-flight mass spectrometer through which the photoions travel, and resonant excitation schemes must be chosen such that the resonance transitions can be substantially power-broadened to cover the isotope shifts. We report resonance ionization measurements of chromium isotope ratios with statistics-limited precision better than 1%.

  15. H$_2$O maser emission from bright rimmed clouds in the northern hemisphere

    OpenAIRE

    Valdettaro, R.; Palla, F; Brand, J.; Cesaroni, R.

    2005-01-01

    We report the results of a multi-epoch survey of water maser observations at 22.2 GHz with the Medicina radiotelescope from 44 bright rimmed clouds (BRCs) of the northern hemisphere identified by Sugitani et al. (1989) as potential sites of star formation. The data span 16 years of observations and allow to draw conclusions about the maser detection rate in this class of objects. In spite of the relatively high far-infrared luminosities of the embedded sources ($L_{\\rm FIR}\\...

  16. Positron emission tracking of individual particles in particle-laden rimming flow

    Science.gov (United States)

    Denissenko, P.; Guyez, E.; Thomas, P. J.; Parker, D. J.; Seville, J. P. K.

    2014-05-01

    The motion of a single tracer particle in particle-laden rimming flows is investigated experimentally by means of Positron Emission Particle Tracking (PEPT). Semi-dilute suspensions, with a volume fraction of 8% of heavy particles are considered. The trajectory of the tracer particle is monitored for several thousand cylinder revolutions and related to the optically recorded drift of the large-scale granular segregation bands developing in the cylinder. Results of the data analysis provide first insights into the relation between behaviour of individual particles and the spatiotemporal dynamics displayed by the macroscopic particle-segregation patterns.

  17. Positron emission tracking of individual particles in particle-laden rimming flow

    International Nuclear Information System (INIS)

    The motion of a single tracer particle in particle-laden rimming flows is investigated experimentally by means of Positron Emission Particle Tracking (PEPT). Semi-dilute suspensions, with a volume fraction of 8% of heavy particles are considered. The trajectory of the tracer particle is monitored for several thousand cylinder revolutions and related to the optically recorded drift of the large-scale granular segregation bands developing in the cylinder. Results of the data analysis provide first insights into the relation between behaviour of individual particles and the spatiotemporal dynamics displayed by the macroscopic particle-segregation patterns

  18. Neutron beam research in the Pacific Rim region - an Australian perspective

    International Nuclear Information System (INIS)

    A program of research in neutron scattering was established in Australia in the early 1960's, shortly after the reactor HIFAR commenced full power operation. The program has included elements of regional cooperation from the very early days. A report is given on the present status of australian neutron scattering research, and the activities (including several major new developments) in other Pacific Rim countries are briefly reviewed. Given the increasing sophistication of neutron scattering facilities and techniques, the case for regional cooperation is strongly advocated. 13 refs., 1 tab

  19. The CT flare response of metastatic bone disease in prostate cancer

    International Nuclear Information System (INIS)

    Background New or worsening bone lesions in patients responding to treatment, known as the flare phenomenon is well described on 99mTc-MDP bone scintigraphy, but to our knowledge has not previously been described on CT. The appearance of new or worsening bone sclerosis on CT in patients with prostate cancer may therefore be erroneously classified as disease progression. Purpose To assess the incidence of osteoblastic healing flare response at 3-month CT assessment in patients with castrate-resistant prostate cancer and to identify associated features that enable differentiation from progressive metastatic bone disease at 3 months. Material and Methods CT scans of 67 patients with castrate-resistant prostate cancer undergoing treatment were reviewed by a radiologist blinded to clinical outcome. Changes in number, size, and density of metastatic bone lesions were documented and Response Evaluation Criteria in Solid Tumours (RECIST) in soft tissue lesions, alkaline phosphatase, prostate specific antigen, and 99mTc-MDP bone scans were used for correlation. Results Of the 39 patients who had 3- and 6-month follow-up, eight patients (21%) demonstrated an increase in number, size, or density of sclerotic lesions on the 3-month CT scan despite improvement in PSA and soft tissue lesions. Three out of eight patients (8%) maintained partial response/remained stable at follow-up and were defined as showing a flare response: in this group bone metastases evident on CT showed a qualitative and quantitative increase in density and no lesions faded at 3 months. In contrast, in all patients who progressed at 3 months by PSA/RECIST criteria (n = 8) bone lesions showed a mixed pattern with some lesions increasing and others decreasing in density. Conclusion The incidence of flare response of metastatic bone disease evident at 3-month post-treatment CT in patients with prostate cancer undergoing systemic treatment is 8%. In patients with falling PSA and stable/responding soft tissue disease at 3 months an increase in bone sclerosis in the absence of fading bone metastases can be interpreted as flare and is likely to represent a response

  20. Bone grafts in dentistry

    Directory of Open Access Journals (Sweden)

    Prasanna Kumar

    2013-01-01

    Full Text Available Bone grafts are used as a filler and scaffold to facilitate bone formation and promote wound healing. These grafts are bioresorbable and have no antigen-antibody reaction. These bone grafts act as a mineral reservoir which induces new bone formation.

  1. What Is Bone?

    Science.gov (United States)

    ... Size | S S M M L L Bone Basics Osteoporosis Osteogenesis Imperfecta Paget?s Disease of Bone Related Topics News Glossary ... focus(); */ } //--> Print-Friendly Page Home Bone Basics Osteoporosis Osteogenesis Imperfecta Paget?s Disease of Bone Related Topics About Us ...

  2. The Refined Shock Velocity of the X-Ray Filaments in the RCW 86 Northeast Rim

    CERN Document Server

    Yamaguchi, Hiroya; Castro, Daniel; Williams, Brian J; Lopez, Laura A; Slane, Patrick O; Smith, Randall K; Petre, Robert

    2016-01-01

    A precise measurement of shock velocities is crucial for constraining the mechanism and efficiency of cosmic-ray (CR) acceleration at supernova remnant (SNR) shock fronts. The northeastern rim of the SNR RCW 86 is thought to be a particularly efficient CR acceleration site, owing to the recent result in which an extremely high shock velocity of ~6000 km/s was claimed (Helder et al. 2009). Here we revisit the same SNR rim with the Chandra X-ray Observatory, 11 years after the first observation. This longer baseline than previously available allows us to determine a more accurate proper motion of the nonthermal X-ray filament, revealing a much lower velocity of 3000 \\pm 340 km/s (and even slower at a brighter region). Although the value has dropped to a half of that from the previous X-ray measurement, it is still higher than the mean velocity of the H-alpha filaments in this region (~1200 km/s). This discrepancy implies that the filaments bright in nonthermal X-rays and H-alpha emission trace different velocit...

  3. Characterization/Selection of a Continuous Wave Laser for RIMS Analysis in Nuclear Forensics

    Science.gov (United States)

    Lau, Sunny; Alves, F.; Karunasiri, G.; Smith, C.; Isselhardt, B.

    2015-03-01

    The effort to implement the technology of resonance ionization mass spectroscopy (RIMS) to problems of nuclear forensics involves the use of multiple lasers to selectively ionize the elements of concern. While current systems incorporate pulsed lasers, we present the results of a feasibility study to determine alternative (Continuous Wave) laser technologies to be employed for analysis of the actinides and fission products of debris from a nuclear detonation. RIMS has the potential to provide rapid isotope ratio quantification of the actinides and important fission products for post detonation nuclear forensics. The current approach to ionize uranium and plutonium uses three Ti-Sapphire pulsed lasers capable of a fundamental wavelength range of 700-1000 nm. In this work, we describe the use of a COTS CW laser to replace one of the pulsed lasers used for the second resonance excitation step of plutonium near 847.282 nm. We characterize the critical laser parameters necessary to achieve high precision isotope ratio measurements including the stability over time of the mean wavelength, bandwidth and spectral mode purity. This far narrower bandwidth laser provides a simpler setup, more robust hardware (greater mobility), and more efficient use of laser irradiance.

  4. A Radio and Mid-Infrared Survey of Northern Bright-Rimmed Clouds

    CERN Document Server

    Morgan, L K; Urquhart, J S; Miao, G J; Miao, Glenn.J.White & J.

    2001-01-01

    We have carried out an archival radio, optical and infrared wavelength imaging survey of 44 Bright-Rimmed Clouds (BRCs) using the NRAO/VLA Sky Survey (NVSS) archive, images from the Digitised Sky Survey (DSS) and the Midcourse Space eXperiment (MSX). The data characterise the physical properties of the Ionised Boundary Layer (IBL) of the BRCs. A total of 25 clouds display 20 cm radio continuum emission that is associated with their bright optical rims. The ionising photon flux illuminating these clouds, the ionised gas pressure and the electron density of the IBL are determined. We derive internal molecular pressures for 9 clouds using molecular line data from the literature and compare these pressures to the IBL pressures to determine the pressure balance of the clouds. We find three clouds in which the pressure exerted by their IBLs is much greater than that measured in the internal molecular material. A comparison of external pressures around the remaining clouds to a global mean internal pressure shows th...

  5. Ultratrace analysis of plutonium in environmental samples by resonance ionization mass spectrometry (RIMS)

    International Nuclear Information System (INIS)

    Plutonium is present in the environment mainly as a result of global fallout from nuclear weapons tests, satellite and reactor accidents as well as releases from nuclear facilities. Sensitive and fast detection methods are required for risk assessment, low-level surveillance of the environment, personnel dose monitoring, studies of biological effects and investigations of the migration behavior of plutonium. Furthermore, the isotopic composition is of interest to get information from what source the plutonium contamination originated. Alpha-spectroscopy is most frequently used for the determination of trace amounts of plutonium in the environment with the disadvantage that the detection sensitivity depends on the half-life of the isotope to be measured and that there are limitations in the isotopic resolution. Conventional mass spectrometry may suffer from isobaric interferences. Therefore, in the last years resonant laser ionization mass spectrometry (RIMS) has been explored as an alternative for ultratrace analysis of plutonium. This method provides a high element and isotope selectivity and a good overall efficiency, resulting in a detection limit of ?106 atoms (?0.4 fg). RIMS meets also the requirements of a low background and a short measuring time (1-2 h)

  6. Analysis of physical processes affecting restructuring of UO2 fuel in Rim-zone

    International Nuclear Information System (INIS)

    The purpose of the presented paper is the analysis of the processes affecting so-called 'rim-zone' formation in UO2 and the development of the model describing isotope content profiles at extended burnup. The influence of rim-zone and extended burnup on fuel temperatures is also considered. A brief review of the worldwide models for fission rate and isotope content profiles at extended burnup is given. In this frame, a new model for for prediction of radial profiles of burnup, fission rate and plutonium isotopes have been developed in the TRINITY (Russia). The results from the comparison of the model predictions with experimental data show that the model has good predictability. A new model describing the conditions of dislocation loop nucleation from interstitial atom clusters on fission spikes is also proposed in this paper. The results of the model show that the fuel grain diameter significantly affects the concentration of point defects and dislocation loops. The paper presents the results from the RTOP code calculations of fuel temperature, taking into account non-uniform fission rate and thermal conductivity degradation as result of burnup increasing

  7. SURGICAL SITE INFECTIONS: A STUDY OF INCIDENCE, RISK FACTORS & ANTIMICROBIAL SENSITIVITY AT RIMS, KADAPA, A. P.

    Directory of Open Access Journals (Sweden)

    Giridhar

    2015-08-01

    Full Text Available S urgical site infection is the most common complication following surgical procedures. The aim of the study is to determine the incidence, associated risk factors and antimicrobial sensitivity pattern at RIMS, KADAPA. MATERIALS AND METHODS: This is a prospective study carried at surgical wards of RIMS KADAPA from Jan. 2015 to June 2015. All the patients were followed for 30 days for development of surgical site infection. Infected cases were identified u sing CDC, criteria. All the data are expressed in percentage. RESULTS : The overall prevalence of surgical site infection is 19%. The incidence was more common in age group above 40 years. The risk factors associated with SSI are long stay in hospital (14% , abdominal surgeries, long duration of surgery, and diabetes. The most common organism isolated is Staphylococcus aureus (30%. CONCLUSION: Surgical site infection is most common following surgery. Significant determinants are long stay in the ward, abdomi nal surgeries, emergency surgeries and diabetes. Effective infection control measures and good regular surveillance will improve the SSI rate to an acceptable level.

  8. The GT-MHR - clear, economic, and safe power for the Pacific Rim

    International Nuclear Information System (INIS)

    In recent decades the nations of the Pacific Rim have outpaced the rest of the world in economic growth. Beyond an abundant labor market and the region's natural resources, energy has played a pivotal role in fuelling this boom. The diverse sources of this energy largely reflect the naturally occurring fuel assets in the Rim countries. Only in the countries where these resources are less plentiful has nuclear energy become a significant sources of electric power generation. Persuasive as the argument for non-polluting power may be by itself it does not sell the nuclear energy option. In addition to being clean it must also be economically competitive and very safe. The authors claim that the Gas-Turbine Modular Helium Reactor (GT-MHR) is an advances nuclear power system that addresses the issues, and should be viewed as an attractive candidate to meet future energy needs. The GT-MHR derives from the coupling of a small, passively safe, modular reactor directly with a compact power conversion module. It uses the Brayton cycle to produce electricity directly with the primary helium coolant driving the turbine-generator. Thus, it shows promise for a quantum reduction in power generation costs by increasing plant efficiency to a remarkable 48% This paper highlights the advantages of the fact that the design is based on proven technology, and offers a clean, economic and safe energy for electricity and high temperature process heat. 2 refs., 4 figs

  9. Liprin-?2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.

    Science.gov (United States)

    Spangler, Samantha A; Schmitz, Sabine K; Kevenaar, Josta T; de Graaff, Esther; de Wit, Heidi; Demmers, Jeroen; Toonen, Ruud F; Hoogenraad, Casper C

    2013-06-10

    The presynaptic active zone mediates synaptic vesicle exocytosis, and modulation of its molecular composition is important for many types of synaptic plasticity. Here, we identify synaptic scaffold protein liprin-?2 as a key organizer in this process. We show that liprin-?2 levels were regulated by synaptic activity and the ubiquitin-proteasome system. Furthermore, liprin-?2 organized presynaptic ultrastructure and controlled synaptic output by regulating synaptic vesicle pool size. The presence of liprin-?2 at presynaptic sites did not depend on other active zone scaffolding proteins but was critical for recruitment of several components of the release machinery, including RIM1 and CASK. Fluorescence recovery after photobleaching showed that depletion of liprin-?2 resulted in reduced turnover of RIM1 and CASK at presynaptic terminals, suggesting that liprin-?2 promotes dynamic scaffolding for molecular complexes that facilitate synaptic vesicle release. Therefore, liprin-?2 plays an important role in maintaining active zone dynamics to modulate synaptic efficacy in response to changes in network activity. PMID:23751498

  10. Definition imaging of an orebody with the radio imaging method (RIM)

    International Nuclear Information System (INIS)

    Waste rock dilution is an economic concern in the planning and design of mining methods for mineralized ore zones. Diamond core drilling and mineralogical examination of core are routinely used to determine the general shape of the ore body. Drilling on closer centers enhances the definition of the mineralization and oregrade across the orebody. In a practical sense, drilling time and cost limit definition. Crosshole scanning between drillholes with the radio imaging method (RIM) has been used to map changes in mineralization in the rock mass. The magnitude and phase of the RIM radio wave depend on the electrical conductivity of the rock mass. The conductivity strongly depends on the percent mineralization. Since the attenuation rate and phase constants of the radio wave are proportional to the one half power of conductivity, the measured crosshole radio wave data can be processed in a tomography algorithm to reconstruct images (map the change in conductivity (mineralization)). The tomography image enhances definition in the orebody while reducing the number of drillholes. This paper compares reconstructed images of the radio wave propagation constants to percent mineralization in the ore body

  11. Alumina+Silica+/-Germanium Alteration in Smectite-Bearing Marathon Valley, Endeavour Crater Rim, Mars

    Science.gov (United States)

    Mittlefehldt, D. W.; Gellert, R.; Van Bommel, S.; Arvidson, R. E.; Clark, B. C.; Ming, D. W.; Schroeder, C.; Yen, A. S.; Fox, V. K.; Farrand, W. H.; Jolliff, B. L.

    2016-01-01

    Mars Exploration Rover Opportunity has been exploring Mars for 12+ years, and is presently investigating the geology of a western rim segment of 22 kilometers diameter, Noachian- aged Endeavour crater. The Alpha Particle X-ray Spectrometer has determined the compositions of a pre-impact lithology, the Matijevic fm., and polymict impact breccias ejected from the crater, the Shoemaker fm. Opportunity is now investigating a region named Marathon Valley that cuts southwest-northeast through the central portion of the rim segment and provides a window into the lower stratigraphic record. (Geographic names used here are informal.) At the head of Marathon Valley, referred to here as Upper Marathon Valley, is a shallow, ovoid depression approximately 25×35 millimeters in size, named Spirit of Saint Louis. Layering inside Spirit of Saint Louis appears continuous with the Upper Marathon Valley rocks outside, indicating they are coeval. Spirit of Saint Louis is partly bounded by approximately 10-20 centimeters wide zone containing reddish altered rocks (red zone). Red zones also form prominent curvilinear features in Marathon Valley. Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) spectra provide evidence for a really extensive Fe-Mg smectite in the Marathon Valley region, indicating distinct styles of aqueous alteration. The CRISM detections of smectites are based on metal-OH absorptions at approximately 2.3 and 2.4 micron that are at least two times the background noise level.

  12. A ceramic/slag interface as an analog for accretion of hot refractory objects and rim formation

    Science.gov (United States)

    Paque, J. M.; Bunch, T. E.

    1994-01-01

    Refractory inclusions or Ca-Al-rich inclusions (CAI's) from carbonaceous chondrites span a wide range of bulk compositions that cannot be explained either by segregation from a gas of solar composition at different points in the condensation sequence or by fractional crystallization from a parent liquid. CAI's are commonly rimmed by Wark-Lovering (W-L) rims, a series of nearly monomineralic layers that have been a source of controversy since the variety of rim sequences occurring on different types of CAI's from Allende were described. The origin of these distinctive features has not yet been resolved, with proponents of accretion, condensation, flash heating, ablation, evaporation, etc. Rims have generated considerable interest because they potentially contain clues to conditions experienced by CAI's after the formation of the inclusion and prior to incorporation into the parent body. Ceramic bricks in contact with hot steel slag may produce reaction products in rimlike fashion similar to those found in CAI's. The similarity between the mineralogy of blast furnace slags and CAI's has long been recognized, with both containing unusual phases not found in terrestrial materials. We provide here a comparison between a ceramic brick/slag multiple-layered interface and a multiple-layered interface between a melilite-perovskite object and a melilite-spinel object in the Allende inclusion USNM 4691-1. These results have implications in interpreting the origin of rims and the textures and compositions of CAI's.

  13. BONE IN OSTEOPETROSIS

    Directory of Open Access Journals (Sweden)

    Ramkumar

    2014-04-01

    Full Text Available Osteopetrosis, a generalized developmental bone disease due to genetic disturbances, characterized by failure of bone re sorption and continuous bone formation making the bone hard, dense and brittle. Bones of intramembranous ossification and enchondrial ossification are affected genetically and symmetrically. During the process of disease the excess bone formation obliterates the cranial foramina and presses the optic, auditory and facial nerves resulting in defective vision, impaired hearing and facial paralysis. The bone formation in osteopetrosis affects bone marrow function leading to severe anemia and deficient of blood cells. The bone devoid of blood supply due to compression of blood vessels by excess formation of bone are prone to osteomyelitic changes with suppuration and pathological fracture if exposed to infection. Though the condition is chronic progressive, it produces changes leading to fatal condition, it should be studied thoroughly by everyone and hence this article presents a classical case of osteopetrosis with detailed description and discussion for the benefit of readers

  14. Stability of one-plate fixation for zygomatic bone fracture

    International Nuclear Information System (INIS)

    We performed a comparative study of clinical zygomatic bone stability following open reduction by one-plate versus multiple-plate fixation. This retrospective study utilized cephalometric radiographs of three dimensional CT which were taken within 1 week and more than 2 months postoperatively. Twenty-three patients who sustained unilateral simple zygomatic bone fracture and underwent open reduction in our unit were included in this study. Of these patients, 15 fractures were fixed using one mini-plate, and 8 fractures were fixed using two or three mini-plates. All of the patients in the multiple-fixation group sustained simple zygomatic bone fractures, besides impure type blow out fractures (3 cases), or open wounds around the orbital rim (5 cases). Two measurements representing vertical and horizontal changes were obtained to evaluate postoperative zygomatic bone movement. Statistical analyses of cephalometric measurements (vertical and horizontal) did not show any significant differences between the two groups. These findings suggested that one-plate fixation for zygomatic bone fracture was sufficiently rigid when the fracture was not comminuted and three-point alignment could be achieved. (author)

  15. Does running strengthen bone?

    Science.gov (United States)

    Boudenot, Arnaud; Achiou, Zahra; Portier, Hugues

    2015-12-01

    Bone is a living tissue needing mechanical stress to maintain strength. Traditional endurance exercises offer only modest effects on bone. Walking and running produce low impact but lead to bone fatigue. This article is specifically addressed to therapists and explains the mechanisms involved for the effects of exercise on bone. Intermittent exercise limits bone fatigue, and downhill exercises increase ground impact forces and involve eccentric muscle contractions, which are particularly osteogenic. PMID:26562001

  16. Metastatic bone disease

    OpenAIRE

    Errol U. Hutagalung

    2004-01-01

    Metastatic bone disease is the most common malignancy of bone, it is estimated that 70% of all malignant bone tumors are metastatic in origin. At autopsy it has been reported between 30 to 85% of patients who die from cancer show occult skeletal metastases. Bone is the third most common site of metastatic process after lung and liver. 80% of metastatic bone disease arise from Ca of breast, prostate, lung, kidney and thyroid. Typical location are thoracolumbal spine, pelvis, ribs, skull and pr...

  17. MRI of degenerative bone marrow lesions in experimental osteoarthritis of canine knee joints

    International Nuclear Information System (INIS)

    Objective. The objective of this study was to determine the value of MRI in the detection of degenerative bone marrow abnormalities in an animal osteoarthritis model. Design. In 10 dogs with experimentally induced unilateral osteoarthritis of the knee, MRI was performed using two-dimensional spin-echo (2D-SE) and three-dimensional gradient-echo (3D-GE) imaging. Contrast enhanced T1-weighted 2D-SE sequences were also obtained after injection of gadolinium-DTPA. The results were compared with the gross and histopathologic findings and with radiography. Results. Histopathologic specimens revealed 21 osteosclerotic lesions and 5 intraosseous cysts. On 2D-SE images, 24 of 26 lesions were detected, while 21 of 26 lesions were identified on 2D-GE sequences. Radiography, including conventional tomography, demonstrated 9 of 26 lesions. Regardless of the sequence weighting, all osteosclerotic lesions appeared hypointense on MRI. Signal loss in bone sclerosis resulted primarily from the reduction of intact fat marrow, the increased bone density being of secondary importance. Quantitative signal analysis allowed approximate estimation of the grade of sclerosis. On postcontrast images, sclerotic bone remained hypointense, although significant but non-specific enhancement relative to the normal fat marrow was observed. The extent of contrast enhancement did not correlate with the grade of osteosclerosis. All five cysts were readily diagnosed by MRI. Cysts displayed either central or marginal contrast enhancement within their cavities. Conclusions. MRI provides a sensitive method for the diagnosis of osteoarthritic bone abnormalities, allowing their differentiation from most non-degenerative subarticular lesions. (orig.). With 1 tab

  18. Bisphosphonate-Related Osteonecrosis of the Jaw Bone: Radiological Pattern and the Potential Role of CBCT in Early Diagnosis

    Directory of Open Access Journals (Sweden)

    James Olutayo

    2010-04-01

    Full Text Available Objectives: To systematize the clinico-radiological symptoms and course of bisphosphonate-related osteonecrosis of jaw bone and to evaluate the diagnostic potential of various radiological techniques to detect mild osteonecrosis in each stage of the disease.Material and Methods: The sample consisted of 22 patients previously diagnosed with extraoral malignant disease. Diagnosis was based on a clinical examination in conjunction to digital panoramic radiography and cone beam computed tomography (CBCT. Two dentomaxillofacial radiologists reviewed all images.Results: Twenty patients showed mandibular involvement clinically, while two others had a maxillary involvement. Four stages of the disease were proposed based on the clinico-radiological findings. Subclinical cortical and lamina dura thickening was detected with only three-dimensional CBCT and periapical images, while ulceration and cortical bone thickening was detected only by three-dimensional CBCT. Mixed sclerotic, lytic bone destruction involving alveolar and basal bone with or without encroachment on the mandibular canal, pathological mandibular fractures were detected by two-dimensional panoramic and three-dimensional CBCT images. Other findings are non healing extraction sockets, periapical radiolucencies, osteolysis, sequestra, oroantral fistula, and periosteal new bone formation.Conclusions: The present study showed that bisphosphonate-related osteonecrosis of jaw bone occurs in four distinct clinico-radiological stages. For mild cases, panoramic image diagnosis was much less obvious, whereas cone beam computed tomography was able to fully characterise the bony lesions and describe their extent and involvement of neighbouring structures in all cases. Thus cone beam computed tomography might better contribute to the prevention of bisphosphonate-related osteonecrosis of jaw bone as well to the disease management.

  19. Estrogen and bone metabolism.

    Science.gov (United States)

    Väänänen, H K; Härkönen, P L

    1996-05-01

    Estrogen plays an important role in the growth and maturation of bone as well as in the regulation of bone turnover in adult bone. During bone growth estrogen is needed for proper closure of epiphyseal growth plates both in females and in males. Also in young skeleton estrogen deficiency leads to increased osteoclast formation and enhanced bone resorption. In menopause estrogen deficiency induces cancellous as well as cortical bone loss. Highly increased bone resorption in cancellous bone leads to general bone loss and destruction of local architecture because of penetrative resorption and microfractures. In cortical bone the first response of estrogen withdrawal is enhanced endocortical resorption. Later, also intracortical porosity increases. These lead to decreased bone mass, disturbed architecture and reduced bone strength. At cellular level in bone estrogen inhibits differentiation of osteoclasts thus decreasing their number and reducing the amount of active remodeling units. This effect is probably mediated through some cytokines, IL-1 and IL-6 being strongest candidates. Estrogen regulates the expression of IL-6 in bone marrow cells by a so far unknown mechanism. It is still uncertain if the effects of estrogen on osteoblasts is direct or is due to coupling phenomenon between bone formation to resorption. PMID:8865143

  20. Nd and Sr isotope compositions in modern and fossil bones - Proxies for vertebrate provenance and taphonomy

    Science.gov (United States)

    Tütken, Thomas; Vennemann, Torsten W.; Pfretzschner, Hans-U.

    2011-10-01

    Rare earth elements (REE), while not essential for the physiologic functions of animals, are ingested and incorporated in ppb concentrations in bones and teeth. Nd isotope compositions of modern bones of animals from isotopically distinct habitats demonstrate that the 143Nd/ 144Nd of the apatite can be used as a fingerprint for bedrock geology or ambient water mass. This potentially allows the provenance and migration of extant vertebrates to be traced, similar to the use of Sr isotopes. Although REE may be enriched by up to 5 orders of magnitude during diagenesis and recrystallization of bone apatite, in vivo143Nd/ 144Nd may be preserved in the inner cortex of fossil bones or enamel. However, tracking the provenance of ancient or extinct vertebrates is possible only for well-preserved archeological and paleontological skeletal remains with in vivo-like Nd contents at the ppb-level. Intra-bone and -tooth REE analysis can be used to screen for appropriate areas. Large intra-bone Nd concentration gradients of 10 1-10 3 are often measured. Nd concentrations in the inner bone cortex increase over timescales of millions of years, while bone rims may be enriched over millenial timescales. Nevertheless, ? Nd values are often similar within one ? Nd unit within a single bone. Larger intra-bone differences in specimens may either reflect a partial preservation of in vivo values or changing ? Nd values of the diagenetic fluid during fossilization. However, most fossil specimens and the outer rims of bones will record taphonomic 143Nd/ 144Nd incorporated post mortem during diagenesis. Unlike REE patterns, 143Nd/ 144Nd are not biased by fractionation processes during REE-uptake into the apatite crystal lattice, hence the ? Nd value is an important tracer for taphonomy and reworking. Bones and teeth from autochthonous fossil assemblages have small variations of ±1 ? Nd unit only. In contrast, fossil bones and teeth from over 20 different marine and terrestrial fossil sites have a total range of ? Nd values from -13.0 to 4.9 ( n = 80), often matching the composition of the embedding sediment. This implies that the surrounding sediment is the source of Nd in the fossil bones and that the specimens of this study seem not to have been reworked. Differences in ? Nd values between skeletal remains and embedding sediment may either indicate reworking of fossils and/or a REE-uptake from a diagenetic fluid with non-sediment derived ? Nd values. The latter often applies to fossil shark teeth, which may preserve paleo-seawater values. Complementary to ? Nd values, 87Sr/ 86Sr can help to further constrain the fossil provenance and reworking.

  1. Quantitative analysis of hyperintensity rim sign surrounding MS plaque on T1 weighted images. Comparison with lacunar infarction

    International Nuclear Information System (INIS)

    This study evaluated the incidence of MR findings showing a hyperintensity rim surrounding multiple sclerosis (MS) plaque on T1-weighted images using image analysis software. We also evaluate the efficacy of this MR finding for differentiating between MS and lacunar infarction. We reviewed T1-weighted images in clinically diagnosed MS patients who underwent MR imaging between February 2006 and July 2007. Two hundred and thirty-nine nodular low signal intensities over 5 mm in minimal diameter were observed in 39 MS patients. To compare the incidence of MR findings, we also reviewed T1-weighted images in randomly selected lacunar infarction patients who underwent MR imaging during the same period. There were 51 nodular low signal intensities over 5 mm in shortest diameter in 34 lacunar infarction patients. After standardization of MR images, we calculated each signal intensity at the plaque margin (M.I.) and surrounding white matter (Wh.I.) using plot-profile analysis. We judged that hyperintensity rim sign was positive when the M.I/Wh.I. ratio was over 1.05. Among 239 T1 low intensity plaques in 39 MS patients, hyperintensity rim sign was positive for 81 (33.9%) plaques in 21 (53.8%) patients. Among 51 T1 low intensity lesions in 34 lacunar infarction patients, hyperintensity rim sign was positive for only one lesion in one patient. There were significant differences in the incidence of hyperintensity rim sign between the two patients groups (p<0.0001). On quantitative analysis using imaging standardization and plot-profile analysis, hyperintensity rim sign was observed in one-third of T1 low intensity MS plaques. This finding seems to be useful to differentiate multiple sclerosis from lacunar infarction. (author)

  2. Heat sources for bright-rimmed molecular clouds: CO observations of NGC 7822

    International Nuclear Information System (INIS)

    Observations of the 2.6 mm carbon monoxide line in the bright rim NGC 7822 reveal that the peak excitation and column density of the molecule lie in a ridge ahead of the ionization front. Several possibilities for the excitation of this ridge are discussed. Cosmic rays are shown to provide an excellent heat source for Bok globules, but they can account for only approx.20% of the required heating in NGC 7822. Direct shock or compressional heating of the gas could be adequate only if the pressure inside the cloud is much larger than the thermal pressure. If, in fact, this internal pressure is determined by the source of line broadening (e.g., magnetic fields or turbulence), then shock or compressional heating could be important, and pressure equilibrium may exist between the neutral cloud and the bright rim. Heating by warm grains or by the photoelectric effect is also considered, but such mechanisms are probably not important if the only source of radiation is external to the cloud. This is primarily a result of the low cloud density (approx.103 cm-3) inferred from our observations. The extent to which unknown embedded stars may provide the required gaseous heating cannot be estimated from our observations of NGC 7822.An interesting and new heat source is suggested which may have important applications to bright-rimmed clouds or to any other predominantly neutral clouds that may have undergone some recent compression. We suggest that the heat input to neutral gas due to the relaxation of internal magnetic fields will be greatly enhanced during cloud compression (with or without a shock). We show that the power input to the gas will increase more with increasing density than will the cooling rate. As a result, cloud compression can lead to an increase in the gas temperature for a period lasting several million years, which is the decay time of the compressed field. The observed ridge in NGC 7822 may be due to stimulated release of internal magnetic energy

  3. Evaluation of tsunami potential based on conditional probability for specific zones of the Pacific tsunamigenic rim

    Science.gov (United States)

    Koravos, George Ch.; Yadav, R. B. S.; Tsapanos, Theodoros M.

    2015-09-01

    The Pacific tsunamigenic rim is one of the most tsunamigenic regions of the world which has experienced large catastrophic tsunamis in the past, resulting in huge loss of lives and properties. In this study, probabilities of occurrences of large tsunamis with tsunami intensity (Soloviev-Imamura intensity scale) I ? 1.5, I ? 2.0, I ? 2.5, I ? 3.0, I ? 3.5 and I ? 4.0 have been calculated over the next 100 years in ten main tsunamigenic zones of the Pacific rim area using a homogeneous and complete tsunami catalogue covering the time periods from 684 to 2011. In order to evaluate tsunami potential, we applied the conditional probability method in each zone by considering the inter-occurrence times between the successive tsunamis generated in the past that follow the lognormal distribution. Thus, we assessed the probability of the next generation of large tsunamis in each zone by considering the time of the last tsunami occurrence. The a-posteriori occurrence of the last large tsunami has been also assessed, assuming that the time of the last occurrence coincides with the time of the event prior to the last one. The estimated a-posteriori probabilities exhibit satisfactory results in most of the zones, revealing a promising technique and confirming the reliability of the tsunami data used. Furthermore, the tsunami potential in different tsunamigenic zones is also expressed in terms of spatial maps of conditional probabilities for two levels of tsunami intensities I ? 1.5 and I ? 2.5 during next 10, 20, 50 and 100 years. Estimated results reveal that the conditional probabilities in the South America and Alaska-Aleutian zones for larger tsunami intensity I ? 2.5 are in the range of 92-93%, much larger than the Japan (69%), for a time period of 100 years, suggesting that those are the most vulnerable tsunamigenic zones. The spatial maps provide brief atlas of tsunami potential in the Pacific rim area.

  4. TRIGGERED STAR FORMATION AND YOUNG STELLAR POPULATION IN BRIGHT-RIMMED CLOUD SFO 38

    International Nuclear Information System (INIS)

    We have investigated the young stellar population in and around SFO 38, one of the massive globules located in the northern part of the Galactic H II region IC 1396, using the Spitzer IRAC and MIPS observations (3.6-24 ?m), and followed up with ground-based optical photometric and spectroscopic observations. Based on the IRAC and MIPS colors and H? emission, we identify ?45 young stellar objects (Classes 0/I/II) and 13 probable pre-main-sequence candidates. We derive the spectral types (mostly K- and M-type stars), effective temperatures, and individual extinction of the relatively bright and optically visible Class II objects. Most of the Class II objects show variable H? emission as well as optical and near-infrared photometric variability, which confirm their 'youth'. Based on optical photometry and theoretical isochrones, we estimate the spread in stellar ages to be between 1 and 8 Myr with a median age of 3 Myr and a mass distribution of 0.3-2.2 Msun with a median value around 0.5 Msun. Using the width of the H? emission line measured at 10% peak intensity, we derive the mass accretion rates of individual objects to be between 10-10 and 10-8 Msun yr-1. From the continuum-subtracted H? line image, we find that the H? emission of the globule is not spatially symmetric with respect to the O-type ionizing star HD 206267, and the interstellar extinction toward the globule is also anomalous. We clearly detect an enhanced concentration of YSOs closer to the southern rim of SFO 38 and identify an evolutionary sequence of YSOs from the rim to the dense core of the cloud, with most of the Class II objects located at the bright rim. The YSOs appear to be aligned along two different directions toward the O6.5V type star HD 206267 and the B0V type star HD 206773. This is consistent with the Radiation Driven Implosion (RDI) model for triggered star formation. Further, the apparent speed of sequential star formation is consistent with the speed of propagation of shocks in dense globules as derived from numerical simulations of RDI.

  5. Reactive endosteal bone formation

    Energy Technology Data Exchange (ETDEWEB)

    Aoki, Jun; Yamamoto, Itsuo; Hino, Megumu; Kitamura, Nobuyasu; Sone, Teruki; Itoh, Harumi; Torizuka, Kanji

    1987-10-01

    The microstructure of reactive endosteal new bone was examined using undecalcified ground sections in five pathologic conditions (bone metastasis from prostate cancer in seven cases, intervertebral osteochondrosis in five, Paget disease in four, chronic suppurative osteomyelitis in two, and fracture healing in one). To determine a basic form of rapid intramembranous bone formation, fetal rat calvaria and primitive bones made in clonal osteogenic cell culture were also observed. In slow bone-forming conditions, lamellar new bone was deposited on pre-existing trabecular surface and caused trabecular thickening on radiographs. In contrast, in rapid bone-forming conditions, woven bone was deposited as spicules extending from trabecular surface so as to form new networks on intertrabecular space. This causes obscurity of trabecular margins radiographically. Reactive endosteal bone formation may be nonspecific and have a significance for assessing the virulence of underlying pathologic conditions like periosteal reactions.

  6. Rough Design of a Double-Stator Axial Flux Permanent Magnet Generator for a Rim-Driven Marine Current Turbine

    OpenAIRE

    DJEBARRI, Sofiane; Charpentier, Jean-Frederic; SCUILLER, Franck; BENBOUZID, Mohamed; Guemard, Sylvain

    2012-01-01

    This paper deals with the rough design of a Double-Stator Axial Flux Permanent Magnet Machine (DSAFPM) for a rim-driven Marine Current Turbine (MCT). The DSAFPM machine will be compared to a previously developed and realized Radial Flux Permanent Magnet Machine (RFPM); given the same rim-driven MCT specifications. For that purpose, a first-order electromagnetic design model and a thermal one are developed and used to compare active part mass, cost, and thermal behavior of the two machines. Th...

  7. Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

    OpenAIRE

    Lu, Jun; Machius, Mischa; Dulubova, Irina; Dai, Han; Südhof, Thomas C.; Diana R Tomchick; Rizo, Josep

    2006-01-01

    C 2 domains are well characterized as Ca 2+/phospholipid-binding modules, but little is known about how they mediate protein–protein interactions. In neurons, a Munc13–1 C 2A-domain/RIM zinc-finger domain (ZF) heterodimer couples synaptic vesicle priming to presynaptic plasticity. We now show that the Munc13–1 C 2A domain homodimerizes, and that homodimerization competes with Munc13–1/RIM heterodimerization. X-ray diffraction studies guided by nuclear magnetic ...

  8. Distal myopathies a review: Highlights on distal myopathies with rimmed vacuoles

    Directory of Open Access Journals (Sweden)

    Malicdan May Christine

    2008-01-01

    Full Text Available Distal myopathies are a group of heterogeneous disorders classified into one broad category due to the presentation of weakness involving the distal skeletal muscles. The recent years have witnessed increasing efforts to identify the causative genes for distal myopathies. The identification of few causative genes made the broad classification of these diseases under "distal myopathies" disputable and added some enigma to why distal muscles are preferentially affected. Nevertheless, with the clarification of the molecular basis of specific conditions, additional clues have been uncovered to understand the mechanism of each condition. This review will give a synopsis of the common distal myopathies, presenting salient facts regarding the clinical, pathological, and molecular aspects of each disease. Distal myopathy with rimmed vacuoles, or Nonaka myopathy, will be discussed in more detail.

  9. Origin and nature of intercrater plains in northwestern rim of Hellas Basin

    Science.gov (United States)

    Salese, F.; Mangold, N.; Ansan, V.; Carter, J.; Ody, A.; Poulet, F.; Ori, G. G.

    2015-10-01

    The nature and origin of intercrater plains within the martian cratered highlands is a major unresolved and controversial issue that have been somewhat enigmatic, receiving little attention since the Mariner era [1,2,3,4,5]. Are flat-lying smooth plains sedimentary or volcanic or both ? Whether these plains are mainly constituted of volcanic material or sediments is a crucial difference for understanding the surface environment of the Noachian period. In order to answer to previous question, we focus our study on the NW rim of Hellas basin defining first the relative stratigraphy and absolute age, throughout crater counting method,of the different units by a precise mapping and correlating then these units with mineralogy and texture.

  10. Numerical Simulation of Stresses in Thin-rimmed Spur Gears with Keyway

    Directory of Open Access Journals (Sweden)

    B. Br?žek

    2003-01-01

    Full Text Available This paper contains an investigation of the key on a stress distribution in a thin-rimmed spur gear. A stress analysis was carried out by means of the Finite Element Method (FEM. The 2D-FE analysis has helped to find the influence of turning the gearing towards the keyway on the stress in the loaded root of the tooth and in the keyway. 2D and 3D numerical analysis has been used to find mutual influence of every single notch (root of tooth and keyway, influence of thickness of the hub, length of the key and the form of loading. Verification has been carried out through experimental method.

  11. [Anesthetic Management of Laparoscopic Nephrectomy for a Renal Cancer Patient with Distal Myopathy of Rimmed Vacuole].

    Science.gov (United States)

    Saito, Junichi; Noguchi, Satoko; Matsumoto, Anna; Jinushi, Kei; Kasai, Toshinori; Kitayama, Masato; Hirota, Kazuyoshi

    2015-02-01

    A 56-year-old male with distal myopathy of rimmed vacuoles underwent laparoscopic nephrectomy. Anesthesia was induced with propofol, remifentanil and ketamine. Tracheal intubation using McGRATH was uneventful without using muscle relaxants. Then ultrasound-guided right thoracic paravertebral (TPVB) block was performed using 20 ml 0.75% ropivacaine with 10 ml 2% lidocaine by 3 injections of 10 ml each at T9 to T11. General anesthesia was maintained with propofol, remifentanil and ketamine monitoring bispectral index. Good surgical condition and pneumoperitoneum were maintained without using muscle relaxants. His postoperative course was smooth and uneventful, even though a small amount of fentanyl was administrated to relieve wound pain. This case suggests that McGRATH and ultrasound-guided TPVB can be one of the options to avoid using muscle relaxants in patient with neuromuscular disease. PMID:26121810

  12. Development of RIMS apparatus for isotope analysis of calcium in nuclear waste materials

    International Nuclear Information System (INIS)

    We have developed a frequency stabilized laser system of RIMS analysis of a long-lived radionuclide of calcium (41Ca) in concrete waste materials. A stable reference laser has been developed using magnetically induced circular dichroism of atomic rubidium. The frequency stability was estimated to be 50 kHz over 8-h period from beat frequency measurement. Furthermore, a computer-controlled fringe offset lock system has been developed to transfer the high frequency stability to the other lasers for three-step excitation of atomic calcium. By using the system precise frequency tuning of 1 MHz error over 1 GHz scan was realized. The overall frequency tuning precision was also confirmed by a multistep fluorescence and resonance ionization spectroscopy of calcium. (author)

  13. Growth and instability of the liquid rim in the crown splash regime

    CERN Document Server

    Agbaglah, G

    2014-01-01

    We study the formation, growth, and disintegration of jets following impact of a drop on a thin film of the same liquid for We < 1000 and Re < 2000 using a combination of numerical simulations and linear stability theory (Agbaglah et al. 2013). Our simulations faithfully capture this phenomena and are in good agreement with experimental profiles obtained from high-speed X-ray imaging.We obtain scaling relations from our simulations and use these as inputs to our stability analysis. The resulting prediction for the most unstable wavelength are in excellent agreement with experimental data. Our calculations show that the dominant destabilizing mechanism is a competition between capillarity and inertia but that deceleration of the rim provides an additional boost to growth. We also predict over the entire parameter range of our study the number and timescale for formation of secondary droplets formed during a splash, based on the assumption that the most unstable mode sets the droplet number.

  14. Descemet membrane endothelial keratoplasty with a stromal rim in the treatment of posterior polymorphous corneal dystrophy

    Directory of Open Access Journals (Sweden)

    Pavel Studeny

    2012-01-01

    Full Text Available A 20-year-old patient, diagnosed with posterior polymorphous corneal dystrophy, developed corneal edema for which he underwent Descemet membrane endothelial keratoplasty with a stromal rim (DMEK-S in the right eye. No intra- or postoperative complications were noted. At the last follow-up 2 years and 9 months after the procedure, the best corrected visual acuity was 1.0 and endothelial cell density declined from 3533 cells/mm 2 to 1012 cells/mm 2 . Despite the endothelial cell loss, DMEK-S appears to be a good alternative to other surgical techniques for the treatment of corneal endotheliopathies, and it may be of benefit to young patients.

  15. High-R Walls for New Construction Structural Performance: Integrated Rim Header Testing

    Energy Technology Data Exchange (ETDEWEB)

    DeRenzis, A. [NAHB Research Center, Upper Marlboro, MD (United States); Kochkin, V. [NAHB Research Center, Upper Marlboro, MD (United States); Wiehagen, J. [NAHB Research Center, Upper Marlboro, MD (United States)

    2013-01-01

    Two prominent approaches within the Building America Program to construct higher R-value walls have included use of larger dimension framing and exterior rigid foam insulation. These approaches have been met with some success; however for many production builders, where the cost of changing framing systems is expensive, the changes have been slow to be realized. In addition, recent building code changes have raised some performance issues for exterior sheathing and raised heel trusses, for example, that indicates a need for continued performance testing for wall systems. The testing methods presented in this report evaluate structural rim header designs over openings up to 6 ft wide and applicable to one- and two-story homes.

  16. Studies on the abnormal accumulations in vertebrae found on the bone scintigram in cancer patients

    International Nuclear Information System (INIS)

    From Jan. 1975 to Dec. 1977, 700 patients with various types of cancer were examined by bone scanning with sup(99m)Tc-phosphate compounds for metastatic bone lesions at the National Cancer Center Hospital. Among these selected 156 patients, significant accumulations were found in 120, and equivocal in 21. The remaining 15 showed both significant and equivocal accumulations. In 116 out of 135 (120 + 15) patients, the significant accumulations were due to metastases; and in 19 out of 36 (21 + 15) patients, the equivocal accumulations were due to metastases. Our careful investigation disclosed that some of the benign conditions could present somewhat different scintigraphic patterns from the metastases. These are as follows; (1) a cushion-like accumulation in the intervertebral space in the cases with disc degeneration, which is occasionally noted also in the cases with collapse of the vertebral body, (2) an irregular marginal accumulation of the vertebral body with an occasional cushion-like accumulation in the intervertebral space in the cases spondylosis deformans, (3) a vague and equivocal accumulation covering an entire vertebral body with an occasional extension to the next vertebral body in the cases with spondylosis deformans, (4) symmetrical accumulations in the intervertebral joints due to sclerotic changes. The 4th pattern mentioned above may be noted in the cases with metastases also. (author)

  17. RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays

    Directory of Open Access Journals (Sweden)

    Hennessy Bryan T

    2008-12-01

    Full Text Available Abstract Background Reverse Phase Protein Arrays (RPPA are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technologies, substantial amounts of analytical data are generated. Over 1000 samples may be printed on a single nitrocellulose slide. Up to 100 different proteins may be assessed using immunoperoxidase or immunoflorescence techniques in order to determine relative amounts of protein expression in the samples of interest. Results In this report an RPPA Information Management System (RIMS is described and made available with open source software. In order to implement the proposed system, we propose a metadata format known as reverse phase protein array markup language (RPPAML. RPPAML would enable researchers to describe, document and disseminate RPPA data. The complexity of the data structure needed to describe the results and the graphic tools necessary to visualize them require a software deployment distributed between a client and a server application. This was achieved without sacrificing interoperability between individual deployments through the use of an open source semantic database, S3DB. This data service backbone is available to multiple client side applications that can also access other server side deployments. The RIMS platform was designed to interoperate with other data analysis and data visualization tools such as Cytoscape. Conclusion The proposed RPPAML data format hopes to standardize RPPA data. Standardization of data would result in diverse client applications being able to operate on the same set of data. Additionally, having data in a standard format would enable data dissemination and data analysis.

  18. Miocene to Present Sea Level and the Origin of Modern Rimmed Atoll Morphology

    Science.gov (United States)

    Toomey, M.; Perron, J. T.; Raymo, M. E.; Ashton, A. D.

    2014-12-01

    Rising sea-level over the next century will reshape our coastlines and make low-lying islands more vulnerable to extreme events. Atolls could potentially provide unique geologic records from periods of high sea level analogous to those we might experience over the coming centuries. However, sea-level records from atolls have been largely overlooked, in part because the processes that shape coral reef and atoll form are often complex and, in many cases, remain unexplored. Darwin's canonical model, which proposes an evolution from fringing reef to barrier reef to atoll as an ocean island ages and subsides, cannot explain the stratigraphy or morphology of many island reefs. We will present a study that combines a numerical model of reef development with existing stratigraphic records from Pacific atolls. The model, driven by sea level, simulates the evolution of atoll morphology using parameterizations of coral growth, rim derived sediment and in situ production, dissolution, and subsidence. We use it to solve for late-Miocene to present sea level by iteratively changing the ice volume and deep-ocean temperature corrections for converting deep-ocean, benthic, ?18O to sea level and finding the best-fit between the model output and corelog stratigraphy from Enewetak Atoll. We then compare lagoon depths produced by the model for different island sizes and dissolution rates (but the same subsidence and sediment production rates) to an independent dataset of real-world observations from the Marshall, Gilbert and Caroline Island chains. Our model results suggest that a period of sustained low sea level occurred during the late Miocene before rising above present moving into the Pliocene. We propose that it was atoll exposure and enhanced lagoon dissolution during the subsequent sea-level fall since the late Pliocene, ~2.7 Ma - not crustal subsidence, as Darwin's canonical model of atoll evolution presumes - that likely drove the development of modern rimmed atoll morphology.

  19. Distal myopathy with rimmed vacuoles: Report on clinical characteristics in 23 cases

    Directory of Open Access Journals (Sweden)

    Nalini A

    2010-01-01

    Full Text Available Background: Distal myopathy with rimmed vacuoles (DMRV is an autosomal recessive (AR myopathy characterized clinically by the preferential involvement of the tibialis anterior and has been reported predominantly in the Japanese population. Materials and Methods: A case series of DMRV patients seen over a period of 3 years at a tertiary national referral center for neurological disorders in south India. Results: We describe the clinical characteristics, muscle magnetic resonance imaging (MRI findings and classical histopathological feature in 23 patients. There were 12 men and 11 women. Mean age of onset was 27.04 ± 6.35 years (10-39 years. Onset was in the second or third decade in a majority. Mean age at presentation was 33.95 ± 6.35 years (25-48 years. Mean duration of illness was 6.74 ± 4.8 years (1-18 years. Consanguinity was reported in eight (34.8% patients. The predominant and initial manifestation was bilateral foot drop in all patients. Muscle MRI demonstrated classical involvement of the anterior compartment muscles of the lower legs and the posterior compartment muscles of the thighs and the quadriceps was normal in all. Muscle histopathology showed numerous fibers containing rimmed vacuoles. Necrotic fibers or phagocytosis or regenerating fibers were rarely noted or were absent. Conclusions: DMRV is a rare AR myopathy. The disorder presents as progressive foot drop and hence has many differential diagnoses. It is easily mistaken as neuropathy of hereditary nature and hence it is extremely important to recognize the preferential muscle involvement and characterize the phenotype. This is the first report from India with patients having characteristic phenotype of Nonaka?s/AR hereditary inclusion body myopathy with quadriceps sparing, and all were confirmed by histopathology.

  20. La Niña diversity and Northwest Indian Ocean Rim teleconnections

    Science.gov (United States)

    Hoell, Andrew; Funk, Christopher C.; Barlow, Mathew

    2014-01-01

    The differences in tropical Pacific sea surface temperature (SST) expressions of El Niño-Southern Oscillation (ENSO) events of the same phase have been linked with different global atmospheric circulation patterns. This study examines the dynamical forcing of precipitation during October–December (OND) and March–May (MAM) over East Africa and during December–March (DJFM) over Central-Southwest Asia for 1950–2010 associated with four tropical Pacific SST patterns characteristic of La Niña events, the cold phase of ENSO. The self-organizing map method along with a statistical distinguishability test was used to isolate La Niña events, and seasonal precipitation forcing was investigated in terms of the tropical overturning circulation and thermodynamic and moisture budgets. Recent La Niña events with strong opposing SST anomalies between the central and western Pacific Ocean (phases 3 and 4), force the strongest global circulation modifications and drought over the Northwest Indian Ocean Rim. Over East Africa during MAM and OND, subsidence is forced by an enhanced tropical overturning circulation and precipitation reductions are exacerbated by increases in moisture flux divergence. Over Central-Southwest Asia during DJFM, the thermodynamic forcing of subsidence is primarily responsible for precipitation reductions, with moisture flux divergence acting as a secondary mechanism to reduce precipitation. Eastern Pacific La Niña events in the absence of west Pacific SST anomalies (phases 1 and 2), are associated with weaker global teleconnections, particularly over the Indian Ocean Rim. The weak regional teleconnections result in statistically insignificant precipitation modifications over East Africa and Central-Southwest Asia.

  1. RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays

    Science.gov (United States)

    Stanislaus, Romesh; Carey, Mark; Deus, Helena F; Coombes, Kevin; Hennessy, Bryan T; Mills, Gordon B; Almeida, Jonas S

    2008-01-01

    Background Reverse Phase Protein Arrays (RPPA) are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technologies, substantial amounts of analytical data are generated. Over 1000 samples may be printed on a single nitrocellulose slide. Up to 100 different proteins may be assessed using immunoperoxidase or immunoflorescence techniques in order to determine relative amounts of protein expression in the samples of interest. Results In this report an RPPA Information Management System (RIMS) is described and made available with open source software. In order to implement the proposed system, we propose a metadata format known as reverse phase protein array markup language (RPPAML). RPPAML would enable researchers to describe, document and disseminate RPPA data. The complexity of the data structure needed to describe the results and the graphic tools necessary to visualize them require a software deployment distributed between a client and a server application. This was achieved without sacrificing interoperability between individual deployments through the use of an open source semantic database, S3DB. This data service backbone is available to multiple client side applications that can also access other server side deployments. The RIMS platform was designed to interoperate with other data analysis and data visualization tools such as Cytoscape. Conclusion The proposed RPPAML data format hopes to standardize RPPA data. Standardization of data would result in diverse client applications being able to operate on the same set of data. Additionally, having data in a standard format would enable data dissemination and data analysis. PMID:19102773

  2. X-RAY PROPER MOTIONS AND SHOCK SPEEDS ALONG THE NORTHWEST RIM OF SN 1006

    International Nuclear Information System (INIS)

    We report the results of an X-ray proper-motion measurement for the NW rim of SN 1006, carried out by comparing Chandra observations from 2001 to 2012. The NW limb has predominantly thermal X-ray emission, and it is the only location in SN 1006 with significant optical emission: a thin, Balmer-dominated filament. For most of the NW rim, the proper motion is ?0.''30 yr–1, essentially the same as has been measured from the H? filament. Isolated regions of the NW limb are dominated by nonthermal emission, and here the proper motion is much higher, 0.''49 yr–1, close to the value measured in X-rays along the much brighter NE limb, where the X-rays are overwhelmingly nonthermal. At the 2.2 kpc distance to SN 1006, the proper motions imply shock velocities of ?3000 km s–1 and ?5000 km s–1 in the thermal and nonthermal regions, respectively. A lower velocity behind the H? filament is consistent with the picture that SN 1006 is encountering denser gas in the NW, as is also suggested by its overall morphology. In the thermally dominated portion of the X-ray shell, we also see an offset in the radial profiles at different energies; the 0.5-0.6 keV peak dominated by O VII is closer to the shock front than that of the 0.8-3 keV emission—due to the longer times for heavier elements to reach ionization states where they produce strong X-ray emission.

  3. Roentgenological semiotics of bone and bone joints pathology

    International Nuclear Information System (INIS)

    Physiologic and pathologic processes in bones followed by alternations of bone structure and reflected on roentgenograms are considered and described. Most frequent reasons for roentgenodiagnosis errors in diseases of bone and bone joint apparatus are presented

  4. Enfermedad de Paget en Chile: una serie de 15 pacientes / Paget disease of bone: Report of 15 cases

    Scientific Electronic Library Online (English)

    Gilberto, González V; Francisca, Brusco G; Eugenio, Arteaga U; José, Rodríguez P; Sergio, Jacobelli G; Loreto, Massardo V; Cristián, Ortiz M; Oscar, Contreras O.

    2003-05-01

    Full Text Available [...] Abstract in english Background: Paget disease of bone (PD) is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and m [...] ethods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained data from 15 patients with PD (ten males, eight Chilean, six European and one Asian), eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit). Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Méd Chile 2003; 131: 491-7).

  5. Enfermedad de Paget en Chile: una serie de 15 pacientes Paget disease of bone: Report of 15 cases

    Directory of Open Access Journals (Sweden)

    Gilberto González V

    2003-05-01

    Full Text Available Background: Paget disease of bone (PD is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and methods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained data from 15 patients with PD (ten males, eight Chilean, six European and one Asian, eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit. Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Méd Chile 2003; 131: 491-7.

  6. Bone fragility and imaging techniques

    OpenAIRE

    D’Elia, Giovanni; Caracchini, Giuseppe; Cavalli, Loredana; Innocenti, Paolo

    2009-01-01

    Bone fragility is a silent condition that increases bone fracture risk, enhanced by low bone mass and microarchitecture deterioration of bone tissue that lead to osteoporosis. Fragility fractures are the major clinical manifestation of osteoporosis.

  7. Bone Graft Alternatives

    Science.gov (United States)

    ... spinal deformity, or who have some types of disc herniations. In certain types of spinal fusion, bone grafts or bone graft alternatives are used to replace the cushioning disc material that lies between the vertebrae. When the ...

  8. Calcaneus (Heel Bone) Fractures

    Science.gov (United States)

    ... Right) The fracture has been reduced and the bones held in place with screws. The typical method of realigning the bone fragments and holding them in place with metal plates and screws. .org Page ( 5 ) AAOS does not endorse any ...

  9. Smoking and Bone Health

    Science.gov (United States)

    ... Size | S S M M L L Bone Basics Osteoporosis Osteogenesis Imperfecta Paget?s Disease of Bone Related Topics News Glossary ... Rest and Immobilization Exercise Exercise ( ???? ) Exercise and Osteogenesis Imperfecta Overtraining Risks for Women Oral Health Partner Resources ...

  10. Metastatic Bone Disease

    Science.gov (United States)

    ... tumor. • Fractures. Weakened bones break more easily. A fracture from a minor injury is another possible sign of MBD. • Anemia. The most common sites of spread — spine, pelvis, ribs, skull, upper arm, and long bones of the ...

  11. Diffusion in Bone Tissue

    OpenAIRE

    Lindberg, Gustav

    2013-01-01

    In order to prevent or modify the processes of bone degeneration the modeling and remodeling of bone tissue must be better understood. In this thesis it is assumed that the primary condition leading to bone growth is a change of the chemical environment caused by transport of matter resulting from stress driven diffusion. The change in the chemical environment may consist of changes in the concentration of different substances stimulating, for example, bone building osteoblast ...

  12. Gracile bone dysplasias

    Energy Technology Data Exchange (ETDEWEB)

    Kozlowski, Kazimierz [Department of Medical Imaging, The Children' s Hospital at Westmead, Locked Bag 4001, Westmead 2145, NSW (Australia); Masel, John [Department of Radiology, Royal Children' s Hospital, Brisbane (Australia); Sillence, David O. [Department of Paediatrics and Child Health, The University of Sydney (Australia); Arbuckle, Susan [Department of Anatomical Pathology, The Children' s Hospital at Westmead, NSW (Australia); Juttnerova, Vera [Oddeleni Lekarske Genetiky, Hradec Kralove (Czech Republic)

    2002-09-01

    Gracile bone dysplasias constitute a group of disorders characterised by extremely slender bones with or without fractures. We report four newborns, two of whom showed multiple fractures. Two babies had osteocraniostenosis and one had features of oligohydramnios sequence. The diagnosis in the fourth newborn, which showed thin long bones and clavicles and extremely thin, poorly ossified ribs, is uncertain. Exact diagnosis of a gracile bone dysplasia is important for genetic counselling and medico-legal reasons. (orig.)

  13. Children's bone health

    OpenAIRE

    van der Sluis, I M

    2002-01-01

    The thesis can be divided in two main parts. In the first part (Chapter 2 to 5) bone mineral density, bone metabolism and body composition in healthy children and young adults have been evaluated, while in the second part (Chapter 6 to 10) these issues were studied in children with various diseases. Healthy children were studied to gain references for parameters of bone turnover, and to extend our reference data for bone density and body composition. Furthermore, the effect of ...

  14. Osteocyte Signaling in Bone

    OpenAIRE

    Schaffler, Mitchell B; Kennedy, Oran D.

    2012-01-01

    Osteocytes, the cells residing within the bone matrix and comprising 90% to 95% of the all bone cells, have long been considered quiescent bystander cells compared to the osteoblasts and osteoclasts whose activities cause bone gain and loss, and whose dysfunction lead to growth defects and osteoporosis. However, recent studies show that osteocytes play a crucial, central role in regulating the dynamic nature of bone in all its diverse functions. Osteocytes are now known to be the principal se...

  15. The Effects of Self-Shadowing by a Puffed up Inner Rim in Scattered Light Images of Protoplanetary Disks

    CERN Document Server

    Dong, Ruobing

    2015-01-01

    We explore whether protoplanetary disks with self-shadowing from puffed up inner rims exhibit observable features in scattered light images. We use both self-consistent hydrostatic equilibrium calculations and parameterized models to produce the vertically puffed up inner rims. We find that, in general, the transition between the shadowed and flared regions occurs in a smooth manner over a broad radius range, and no sudden jump exists at the outer edge of the shadow in either the disk temperature or density structures. As a result, a puffed up rim cannot create sharp ring/arc/spiral-arm-like features in the outer disk as have been detected in recent direct NIR imaging of disks. On the other hand, if the puffed up rim has a sharp edge in the vertical direction, the shadowing effect can produce a distinct 3-stage broken power law in the radial intensity profile of the scattered light, with 2 steep surface brightness radial profiles in the inner and outer disk joined by a shallow transition region around the sha...

  16. Thermodynamic model for diffusion controlled reaction rim growth in a binary system: application to the forsterite-enstatite-quartz system.

    Czech Academy of Sciences Publication Activity Database

    Abart, R.; Pertischeva, E.; Fischer, F. D.; Svoboda, Ji?í

    2009-01-01

    Ro?. 309, ?. 2 (2009), s. 114-131. ISSN 0002-9599 R&D Projects: GA MŠk OC 163 Institutional research plan: CEZ:AV0Z20410507 Keywords : Thermodynamic model * diffusion * rim growth Subject RIV: BJ - Thermodynamics Impact factor: 2.284, year: 2009

  17. 75 FR 52969 - Rim of the Valley Corridor Special Resource Study, Los Angeles and Ventura Counties, CA; Notice...

    Science.gov (United States)

    2010-08-30

    ... environmental impact analysis ] process to identify and assess potential impacts of alternative resource... linkages between open space areas; completion of the Rim of the Valley Trail system; preserving... local and regional press media, and will be advertised in a newsletter which will be distributed...

  18. The Effects of Self-shadowing by a Puffed-up Inner Rim in Scattered Light Images of Protoplanetary Disks

    Science.gov (United States)

    Dong, Ruobing

    2015-09-01

    We explore whether protoplanetary disks with self-shadowing from puffed-up inner rims exhibit observable features in scattered light images. We use both self-consistent hydrostatic equilibrium calculations and parameterized models to produce the vertically puffed-up inner rims. We find that, in general, the transition between the shadowed and flared regions occurs in a smooth manner over a broad radius range, and no sudden jump exists at the outer edge of the shadow in either the disk temperature or density structures. As a result, a puffed-up rim cannot create sharp ring/arc/spiral-arm-like features in the outer disk as have been detected in recent direct near-infrared imaging of disks. On the other hand, if the puffed-up rim has a sharp edge in the vertical direction, the shadowing effect can produce a distinct three-stage broken power law in the radial intensity profile of the scattered light, with two steep surface brightness radial profiles in the inner and outer disk joined by a shallow transition region around the shadow edge. These types of scattered light profiles may have already been observed, such as in the recent Subaru direct imaging of the TW Hydrae system.

  19. Isotopic distribution from core to rim of a PWR spent nuclear fuel by shielded laser ablation ICP MS

    International Nuclear Information System (INIS)

    Spent nuclear fuel discharged from a pressurized light water reactor contains fission products, U, Pu, and other actinides. Due to a neutron capture by 238U in the rim region and a temperature gradient between the center and the rim of a fuel pellet, a considerable increase in the concentration of fission products, U, Pu, and other actinides are expected at a pellet periphery. Characterization of the local chemical properties with a varying radial gradient is our main concern. For an analysis, a spent nuclear fuel originating from the Yeonggwang 4 PWR reactor with an average burn up of 55,600 MWd/MtU was chosen as a test specimen. The isotopic ratio was measured from core to rim of the spent fuel by a radiation shielded LA ICP MS system. Sampling was performed along the diameter of a sample specimen by reducing the intervals from 500?m to 100?m. It was observed that the isotopic ratios in the center of a sample specimen remain almost constant and increased near the pellet periphery due to the rim effect. In addition, the isotopic distribution measured by the radiation shielded LA ICP MS was compared with that of the calculated value by the Origin2 code

  20. Observation of a high burnup rim-type structure in an advanced plutonium-uranium carbide fuel

    International Nuclear Information System (INIS)

    The observation is reported of a 'rim-type' structure with small subgrains in an advanced plutonium-uranium carbide (U0.8Pu0.2)C fuel pin, which had been irradiated in the Dounreay Fast Reactor to a burnup of 8.3% FIMA. (orig.)

  1. 76 FR 14697 - Aleris Blanking and Rim Products, Inc., a Division of Aleris International, Inc., Terre Haute, IN...

    Science.gov (United States)

    2011-03-17

    ... the Federal Register on March 2, 2010 (75 FR 9436-9437). The workers produce aluminum blanks and hoops... International, Inc., Terre Haute, IN; Notice of Revised Determination on Reconsideration On February 18, 2010... Blanking and Rim Products, Inc., a division of Aleris International, Inc., Terre Haute, Indiana, who...

  2. Heterogenous Oxygen Isotopic Composition of a Complex Wark-Lovering Rim and the Margin of a Refractory Inclusion from Leoville

    Science.gov (United States)

    Simon, J. I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.

    2014-01-01

    Wark-Lovering (WL) rims [1] surrounding many refractory inclusions represent marker events in the early evolution of the Solar System in which many inclusions were exposed to changes in pressure [2], temperature [3], and isotopic reservoirs [4-7]. The effects of these events can be complex, not only producing mineralogical variability of WL rims [2], but also leading to mineralogical [8-10] and isotopic [7, 11, 12] changes within inclusion interiors. Extreme oxygen isotopic heterogeneity measured in CAIs has been explained by mixing between distinct oxygen gas reservoirs in the nebula [13]. Some WL rims contain relatively simple mineral layering and/or are isotopically homogeneous [14, 15]. As part of a larger effort to document and understand the modifications observed in some CAIs, an inclusion (L6) with a complex WL rim from Leoville, a member of the reduced CV3 subgroup was studied. Initial study of the textures and mineral chemistry was presented by [16]. Here we present NanoSIMS oxygen isotopic measurements to complement these petrologic observations.

  3. Thermal and fluid processes of a thin melt zone during femtosecond laser ablation of glass: the formation of rims by single laser pulses

    International Nuclear Information System (INIS)

    We study the formation mechanism of rims created around femtosecond laser ablated craters on glass. Experimental studies of the surface morphology reveal that a thin rim is formed around the smooth craters and is raised above the undamaged surface by about 50-100 nm. To investigate the mechanism of rim formation following a single ultrafast laser pulse, we perform a one-dimensional theoretical analysis of the thermal and fluid processes involved in the ablation process. The results indicate the existence of a very thin melted zone below the surface and suggest that the rim is formed by the high pressure plasma producing a pressure-driven fluid motion of the molten material outwards from the centre of the crater. The numerical solutions of pressure-driven fluid motion of the thin melt demonstrate that the melt can flow to the crater edge and form a rim within the first nanoseconds of the ablation process. The possibility that a tall rim can be formed during the initial stages of the plasma is suggestive that the rim may tilt outwards towards the low pressure region creating a resolidified melt splash as observed in the experiments. The possibility of controlling or suppressing the rim formation is discussed also

  4. Facts about Broken Bones

    Science.gov (United States)

    ... be able to tell that they broke a bone! Breaking a bone is a big shock to your whole body. ... suggest you do special exercises to improve your strength and flexibility. ... don't break any more bones? Accidents happen, but you’ll stay safer when ...

  5. Magnetic resonance imaging of bone marrow changes in Gaucher disease during enzyme replacement therapy: first German long-term results

    International Nuclear Information System (INIS)

    Objective:. Since 1991, enzyme replacement therapy (ERT) has been available for patients with Gaucher disease in Germany. The aim of this study was to analyse the MR pattern of bone marrow involvement and response to ERT in Gaucher disease type I. Patients and design:. Thirty patients with Gaucher disease type I had MRI examinations prior to initiation of ERT with alglucerase/imiglucerase and during follow-up. Median MR follow-up and duration of ERT were 36 months. Coronal T1- and T2-weighted spin-echo images of the lower extremities were obtained to evaluate changes in the appearance of yellow marrow. MR images were categorized as having either a homogeneous (type A) or non-homogeneous patchy (type B) appearance of bone involvement and response to ERT was assessed by two radiologists. Results:. Overall, 19 of 30 patients (63%) showed an increased signal intensity on T1- and T2-weighted images after 36 months of ERT, consistent with partial reconversion of fatty marrow during treatment. Focal bone lesions surrounded by a low signal intensity (SI) rim did not respond to ERT, suggesting bone infarcts. Of the 11 patients with bone infarcts (low SI rim lesion), 82% had the non-homogeneous type B pattern (P=0.0021). In 86% of patients with splenectomy, bone infarcts were seen (P<0.05). Conclusions:. MRI using T1- and T2-weighted spin-echo sequences is a valuable, non-invasive method for monitoring bone marrow response in patients receiving ERT. A non- homogeneous patchy signal intensity of bone marrow involvement correlates with the presence of bone infarcts (P=0.0021). (orig.)

  6. RIM-DB: a taxonomic framework for community structure analysis of methanogenic archaea from the rumen and other intestinal environments

    Directory of Open Access Journals (Sweden)

    Henning Seedorf

    2014-08-01

    Full Text Available Methane is formed by methanogenic archaea in the rumen as one of the end products of feed fermentation in the ruminant digestive tract. To develop strategies to mitigate anthropogenic methane emissions due to ruminant farming, and to understand rumen microbial differences in animal feed conversion efficiency, it is essential that methanogens can be identified and taxonomically classified with high accuracy. Currently available taxonomic frameworks offer only limited resolution beyond the genus level for taxonomic assignments of sequence data stemming from high throughput sequencing technologies. Therefore, we have developed a QIIME-compatible database (DB designed for species-level taxonomic assignment of 16S rRNA gene amplicon data targeting methanogenic archaea from the rumen, and from animal and human intestinal tracts. Called RIM-DB (Rumen and Intestinal Methanogen-DB, it contains a set of 2,379 almost full-length chimera-checked 16S rRNA gene sequences, including 20 previously unpublished sequences from isolates from three different orders. The taxonomy encompasses the recently-proposed seventh order of methanogens, the Methanomassiliicoccales, and allows differentiation between defined groups within this order. Sequence reads from rumen contents from a range of ruminant-diet combinations were taxonomically assigned using RIM-DB, Greengenes and SILVA. This comparison clearly showed that taxonomic assignments with RIM-DB resulted in the most detailed assignment, and only RIM-DB taxonomic assignments allowed methanogens to be distinguished taxonomically at the species level. RIM-DB complements the use of comprehensive databases such as Greengenes and SILVA for community structure analysis of methanogens from the rumen and other intestinal environments, and allows identification of target species for methane mitigation strategies.

  7. Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch.

    Science.gov (United States)

    Lu, Jun; Machius, Mischa; Dulubova, Irina; Dai, Han; Südhof, Thomas C; Tomchick, Diana R; Rizo, Josep

    2006-07-01

    C(2) domains are well characterized as Ca(2+)/phospholipid-binding modules, but little is known about how they mediate protein-protein interactions. In neurons, a Munc13-1 C(2)A-domain/RIM zinc-finger domain (ZF) heterodimer couples synaptic vesicle priming to presynaptic plasticity. We now show that the Munc13-1 C(2)A domain homodimerizes, and that homodimerization competes with Munc13-1/RIM heterodimerization. X-ray diffraction studies guided by nuclear magnetic resonance (NMR) experiments reveal the crystal structures of the Munc13-1 C(2)A-domain homodimer and the Munc13-1 C(2)A-domain/RIM ZF heterodimer at 1.44 A and 1.78 A resolution, respectively. The C(2)A domain adopts a beta-sandwich structure with a four-stranded concave side that mediates homodimerization, leading to the formation of an eight-stranded beta-barrel. In contrast, heterodimerization involves the bottom tip of the C(2)A-domain beta-sandwich and a C-terminal alpha-helical extension, which wrap around the RIM ZF domain. Our results describe the structural basis for a Munc13-1 homodimer-Munc13-1/RIM heterodimer switch that may be crucial for vesicle priming and presynaptic plasticity, uncovering at the same time an unexpected versatility of C(2) domains as protein-protein interaction modules, and illustrating the power of combining NMR spectroscopy and X-ray crystallography to study protein complexes. PMID:16732694

  8. [Bone metabolism: molecular mechanisms].

    Science.gov (United States)

    Neumann, E; Schett, G

    2007-07-01

    In order to accommodate individual load, the skeletal system is in a continual state of change. Bone metabolism guarantees optimal bone structure. The osteoblasts are responsible for the synthesis and the osteoclasts for resorption of the bone. A finely adjusted interplay between molecular mechanisms leads, via cytokines, hormones and growth factors, to an homeostasis in bone metabolism. Disturbances of this process lead via increased bone resorption to osteoporosis, and via increased synthesis to osteopetrosis. This contribution describes the known molecular mechanisms in this remodelling process. PMID:17562055

  9. Method for fusing bone

    Science.gov (United States)

    Mourant, Judith R. (Los Alamos, NM); Anderson, Gerhard D. (Velarde, NM); Bigio, Irving J. (Los Alamos, NM); Johnson, Tamara M. (Los Alamos, NM)

    1996-01-01

    Method for fusing bone. The present invention is a method for joining hard tissue which includes chemically removing the mineral matrix from a thin layer of the surfaces to be joined, placing the two bones together, and heating the joint using electromagnetic radiation. The goal of the method is not to produce a full-strength weld of, for example, a cortical bone of the tibia, but rather to produce a weld of sufficient strength to hold the bone halves in registration while either external fixative devices are applied to stabilize the bone segments, or normal healing processes restore full strength to the tibia.

  10. Enzymatic maceration of bone

    DEFF Research Database (Denmark)

    Uhre, Marie-Louise; Eriksen, Anne Marie; Simonsen, Kim Pilkjær; Rasmussen, Arne Redsted; Hjort, Benjamin Benn; Lynnerup, Niels

    2014-01-01

    afterwards macerated by one of the two methods. DNA extraction was performed to see the effect of the macerations on DNA preservation. Furthermore, the bone pieces were examined in a stereomicroscope to assess for any bone damage. The results demonstrated that both methods removed all flesh/soft tissue from...... the bones. The DNA analysis showed that DNA was preserved on all the pieces of bones which were examined. Finally, the investigation suggests that enzyme maceration could be gentler on the bones, as the edges appeared less frayed. The enzyme maceration was also a quicker method; it took three hours...

  11. Enzymatic maceration of bone

    DEFF Research Database (Denmark)

    Uhre, Marie-Louise; Eriksen, Anne Marie; Simonsen, Kim Pilkjær; Redsted Rasmussen, Arne; Hjort, Benjamin Benn; Niels Lynnerup, Niels

    2015-01-01

    afterwards macerated by one of the two methods. DNA extraction was performed to see the effect of the macerations on DNA preservation. Furthermore, the bone pieces were examined in a stereomicroscope to assess for any bone damage. The results demonstrated that both methods removed all flesh/soft tissue from...... the bones. The DNA analysis showed that DNA was preserved on all the pieces of bones which were examined. Finally, the investigation suggests that enzyme maceration could be gentler on the bones, as the edges appeared less frayed. The enzyme maceration was also a quicker method; it took three hours...

  12. Early radiologic detection of local recurrence after curettage and acrylic cementation of giant cell tumours

    International Nuclear Information System (INIS)

    Five patients with giant cell tumour of bone, treated with curettage and acrylic cementation, were suspected of having recurrence of tumour 6 months - 6 years after surgery. At repeat surgery, recurrence was histologically verified in three patients, and excluded in two. A review of the radiologic examinations of these patients showed that the only reliable sign of early recurrence showed that the only reliable sign of early recurrence was lysis or non-development of the sclerotic rim adjacent to the radiolucent zone between the cement and the cancellous bone, detectable on conventional radiographs and tomographs. Angiography and scintimetry were not reliable during the first year after the primary surgery. (orig.)

  13. [Bone turnover marker].

    Science.gov (United States)

    Miura, Masakazu; Satoh, Yuki

    2015-10-01

    Recently the clinical application of bone turnover markers (BTMs) have been achieved significant progress and the measurements of these indices give us better understanding of pathogenesis of osteoporosis. BTMs are known the bone formation marker, the bone resorption marker and the bone matrix-related marker, respectively. In the Guidelines for the Use of Bone Metabolic Markers in the Diagnosis and Treatment of Osteoporosis (2012 Edition) from publishing Japan Osteoporosis Society Committee, the newly and commonly BTMs were considered to give the normal reference value in Japanese people, the influence of renal function on BTMs. The flow chart of the measurement of bone resorption markers and bone formation markers when selecting drug treatment for osteoporosis, the evaluation of therapeutic effects of bone antiresorption drugs and/or bone formation promoting drug using bone resorption markers and/or bone formation marker were corrected newly in the guideline 2012 edition. Moreover, BTMs were suggested to contribute to adhere with osteoporosis treatment. BTMs are adapted to selection of the drug for osteoporosis and to evaluate the drug efficacy. Therefore, it is very important to guide the proper application and assessment of BTMs in clinical practice. PMID:26529926

  14. [Bone and Nutrition. Bone and phosphorus intake].

    Science.gov (United States)

    Arai, Hidekazu; Sakuma, Masae

    2015-07-01

    Phosphorus is necessary for bone mineralization. Although adequate phosphorus intake is essential for skeletal mineralization, it is reported that excessive phosphorus intake can induce deleterious effect on bone. Recently, since the Japanese diet has been westernized, phosphorus intake by the meat and dairy products has increased. Furthermore, along with the development of processed foods, excessive intake of inorganic phosphorus from food additives has become a problem. An adverse effect on parathyroid hormone (PTH) secretion from high phosphorus intake was seen only when calcium intake was inadequate. Dietary calcium to phosphorus ratio can be considered as one of the indicators that can predict the health of the bone. PMID:26119308

  15. Nanomaterials and bone regeneration

    Science.gov (United States)

    Gong, Tao; Xie, Jing; Liao, Jinfeng; Zhang, Tao; Lin, Shiyu; Lin, Yunfeng

    2015-01-01

    The worldwide incidence of bone disorders and conditions has been increasing. Bone is a nanomaterials composed of organic (mainly collagen) and inorganic (mainly nano-hydroxyapatite) components, with a hierarchical structure ranging from nanoscale to macroscale. In consideration of the serious limitation in traditional therapies, nanomaterials provide some new strategy in bone regeneration. Nanostructured scaffolds provide a closer structural support approximation to native bone architecture for the cells and regulate cell proliferation, differentiation, and migration, which results in the formation of functional tissues. In this article, we focused on reviewing the classification and design of nanostructured materials and nanocarrier materials for bone regeneration, their cell interaction properties, and their application in bone tissue engineering and regeneration. Furthermore, some new challenges about the future research on the application of nanomaterials for bone regeneration are described in the conclusion and perspectives part. PMID:26558141

  16. Bone stress injuries

    International Nuclear Information System (INIS)

    Bone stress injuries are due to cyclical overuse of the bone. They are relatively common in athletes and military recruits but also among otherwise healthy people who have recently started new or intensive physical activity. Diagnosis of bone stress injuries is based on the patient's history of increased physical activity and on imaging findings. The general symptom of a bone stress injury is stress-related pain. Bone stress injuries are difficult to diagnose based only on a clinical examination because the clinical symptoms may vary depending on the phase of the pathophysiological spectrum in the bone stress injury. Imaging studies are needed to ensure an early and exact diagnosis, because if the diagnosis is not delayed most bone stress injuries heal well without complications

  17. The rim zone of cement based materials - barrier or fast lane for chemical degradation?

    International Nuclear Information System (INIS)

    This contribution focuses exemplarily on the chemical and mineralogical changes in the rim zone of cement paste samples exposed to different chloride solutions (NaCl, KCl, MgCl2 and CaCl2), to hard tap water and to demineralized water. The determination of the Ca(OH)2 and Mg(OH)2 content of the solid phases was performed by means of thermogravimetry with pulverized samples (TGA/SDTA 851, Mettler-Toledo). A potential relation between temperature and the time dependant development of the material due to reactive transport processes will also be addressed. The experiments with tap water showed that the contact between the cement paste samples and hard tap water did not lead to significant changes in the composition of the solid samples or of the reaction solution. This can be attributed to a rapid formation of a protective calcium carbonate layer on the surface of the cement paste. The slight decrease of the Ca2+ content in the solution indicates that the growth of this layer occurs within the first few hours. In contrast to the tap water exposure, the results of the experiments with the MgCl2 solutions show features of an intense attack despite the presence of crystalline covering layers. The quick formation of a thick and dense Mg(OH)2 layer does not provide any protection against reactive transport processes. In this experiment, the degradation rate of Ca(OH)2 as well as the Ca2+ release was higher than in all other experiments. In addition the rapid formation of a Mg(OH)2 layer starting already during the first hour of the experiment did not prevent the chloride ingress compared to the other experiments with chloride solutions. The pH value of the reaction solution remains stable and relatively low which indicates a crystallisation process. In the other experiments, performed with demineralized water, alkali chloride solutions, and the CaCl2 solution, no significant formation of potentially protective covering layers and no development of transport inhibiting properties in the rim zone were observed

  18. Rim-ba: Karya Tari Hasil Refleksi Kehidupan Suku Anak Dalam

    Directory of Open Access Journals (Sweden)

    Sarjiwo Sarjiwo

    2013-11-01

    Full Text Available Karya tari “Rim-ba” merupakan hasil dari refl eksi penata tari terhadap kehidupan Suku Anak Dalam (Orang Rimba di Bukit Duabelas Propinsi Jambi. Hutan yang menjadi habitat dan tempat bernaung Suku Anak Dalam semakin sempit areanya. Hal tersebut disebabkan oleh adanya penebangan liar (illegal logging maupun perluasan lahan perkebunan sawit. Tema yang diangkat dalam garapan karya tari ini adalah perjuangan hidup orang rimba. Bentuk penyajiannya simbolis representasional yang terbagi dalam empat adegan, yaitu adegan satu (introduksi tentang keterbelakangan, adegan dua tentang ritus orang rimba, adegan tiga tentang aktivitas mata pencaharian orang rimba, dan adegan empat tentang perusakan rimba. Karya tari ini didukung oleh empat orang penari. Gerak tari berorientasi pada perilaku kehidupan sehari-hari orang rimba. Musik pengiring merupakan musik hasil editing secara digital dengan software nuendo dengan memasukkan unsur suara vocal. Tata rupa pentas berdasarpada atmosfi r suasana hutan, meliputi property instalasi kayu, akar sulur gantungan dan dedaunan. Busana yangdikenakan menyerupai busana asli Suku Anak Dalam yang sudah dimodifi kasi. Sedangkan tata cahaya yangdigunakan berorientasi pada nuansa cahaya alam.Kata kunci: rimba, suku anak dalam, bukit duabelasABSTRACT“Rim-ba”: A Dance refl ecting the Life of Anak Dalam Tribe. Rimba dance is the result of the choreographer’srefl ection on the life of Anak Dalam tribe (forest people / Orang Rimba in Bukit Duabelas, Jambi province. The forestwhich is the habitat of the tribe is shrinking. This is due to the illegal logging and palm oil agriculture expansion. Thetheme of the dance is about the struggle of forest people in their life. The symbolic, choreographic representation is dividedinto four acts; the fi rst act introduces the underdeveloped condition of the people; the second act shows the rituals practiced by the forest people; the third act shows how the forest people earn their living; and the fi nal act visualizes the forest destruction. The dance is performed by four dancers. The dance movement orientates on the daily behaviors of the forestpeople. The accompanying music is composed and edited digitally by applying nuendo software and inserting vocal element in the software. The stage decoration shows a forest setting which includes wooden property, hanging roots and leaves. The dancers’ costumes resemble the original clothes of Anak Dalam tribe along with some modifi cations, whereas the lighting arrangement is based on natural lighting nuance.Key words: anak dalam dance, bukit duabelas

  19. Monostotic Paget Disease of Bone or Bone Metastasis?

    OpenAIRE

    Özlem Erdem Süer; Jale Meray; Nesrin Demirsoy; Zelal Kele?

    2008-01-01

    Paget’s disease of bone is a metabolic bone disorder with male predominance and characterized by increased bone turnover. Recent literature indicates a reduction in incidence and severity. We report a 55 years old female patient who was admitted with knee pain, and whose pelvis x-ray demonstrated pathological features. She was investigated with preliminary diagnoses of Paget’s disease of bone, osteosclerotic bone metastasis and primary bone tumor. Histopathological examination of bone biopsy ...

  20. Chemical Analysis of Reaction Rims on Olivine Crystals in Natural Samples of Black Dacite Using Energy-Dispersive X-Ray Spectroscopy, Lassen Peak, CA.

    Science.gov (United States)

    Graham, N. A.

    2014-12-01

    Lassen Volcanic Center is the southernmost volcanic region in the Cascade volcanic arc formed by the Cascadia Subduction Zone. Lassen Peak last erupted in 1915 in an arc related event producing a black dacite material containing xenocrystic olivine grains with apparent orthopyroxene reaction rims. The reaction rims on these olivine grains are believed to have formed by reactions that ensued from a mixing/mingling event that occurred prior to eruption between the admixed mafic andesitic magma and a silicic dacite host material. Natural samples of the 1915 black dacite from Lassen Peak, CA were prepared into 15 polished thin sections and carbon coated for analysis using a FEI Quanta 250 Scanning Electron Microscope (SEM) to identify and measure mineral textures and disequilibrium reaction rims. Observed mineralogical textures related to magma mixing include biotite and amphibole grains with apparent dehydration/breakdown rims, pyroxene-rimmed quartz grains, high concentration of microlites in glass matrix, and pyroxene/amphibole reaction rims on olivine grains. Olivine dissolution is evidenced as increased iron concentration toward convolute edges of olivine grains as observed by Backscatter Electron (BSE) imagery and elemental mapping using NSS spectral imaging software. In an attempt to quantify the area of reaction rim growth on olivine grains within these samples, high-resolution BSE images of 30 different olivine grains were collected along with Energy-Dispersive X-Ray Spectroscopy (EDS) of different phases. Olivine cores and rims were extracted from BSE images using Photoshop and saved as separate image files. ImageJ software was used to calculate the area (μm2) of the core and rim of these grains. Average pyroxene reaction rim width for 30 grains was determined to be 11.68+/-1.65 μm. Rim widths of all 30 grains were averaged together to produce an overall average rim width for the Lassen Peak black dacite. By quantifying the reaction rims on olivine grains in the natural samples of Lassen Peak dacite as well as the bulk chemistry of the rock, this provides insight into the storage conditions of the magma chamber and the timing necessary for reactions to form these specific volcanic textures which in turn can be used as a basis for better understanding future experimental reconstruction of this magmatic system.

  1. [Bone and Nutrition. Sclerostin and bone metabolism].

    Science.gov (United States)

    Tatsumi, Sawako; Nagamoto, Kenta; Ogata, Mao; Miyamoto, Ken-ichi

    2015-07-01

    Osteocytes orchestrate bone resorption and bone formation by controlling osteoclast and osteoblast activity. On the other hand, osteocytes secret FGF23 (fibroblast growth factor 23), FGF23 acts on the kidney to control phosphate homeostasis. Sclerostin is also released from osteocytes and it regulated osteoblast activity through Wnt/?-catenin pathway. Therefore, an antibody that targets sclerostin is currently in phase- III clinical trials for the treatment of osteoporosis and it is expected as new therapeutics. PMID:26119318

  2. Building for the Pacific Rim Countries. Energy-efficient building strategies for hot, humid climates

    Energy Technology Data Exchange (ETDEWEB)

    Sheinkopf, K. [ed.

    1991-09-01

    This book has been published by the Solar Energy Industries Association (SEIA), the US trade association of the solar thermal, photovoltaic, and passive solar manufacturers, distributors, and component suppliers. Its purpose is to help architects, builders, and developers construct energy-efficient homes in hot humid climates like the Pacific Rim Countries, and to allow occupants of these homes to enjoy enhanced comfort without reliance on mechanical air-conditioning systems. Two important factors are addressed in this book. First, the past few years have seen a tremendous increase in practical applications of new research. The current popularity of ceiling paddle fans, attic radiant barriers and natural daylighting attest to the importance of keeping up with the latest concepts in energy-reduction and comfort-awareness. Professionals who have been in the field for the past few years may be unaware of the latest research findings--some of which dramatically alter prior thinking on such subjects as natural ventilation or mechanical air conditioning. The second factor is the importance of site-specific characteristics, which greatly affect building strategies and designs. A thorough understanding of the climate is a prerequisite to good building design. Such factors as temperature, humidity, wind speed and direction, and solar radiation must be understood and properly integrated into the design for the home to be truly energy-efficient.

  3. Speciation at the Mogollon Rim in the Arizona Mountain Kingsnake (Lampropeltis pyromelana).

    Science.gov (United States)

    Burbrink, Frank T; Yao, Helen; Ingrasci, Matthew; Bryson, Robert W; Guiher, Timothy J; Ruane, Sara

    2011-09-01

    Studies of speciation and taxon delimitation are usually decoupled. Combining these methods provides a stronger theoretical ground for recognizing new taxa and understanding processes of speciation. Using coalescent methods, we examine speciation, post-speciation population demographics, and taxon delimitation in the Arizona Mountain Kingsnake (Lampropeltis pyromelana), a species restricted to high elevations in southwestern United States and northern Mexico (SW). These methods provide a solid foundation for understanding how biogeographic barriers operate at the regional scale in the SW. Bayesian species delimitation methods, using three loci from samples of L. pyromelana taken throughout their range, show strong support for the existence of two species that are separated by low elevation habitats found between the Colorado Plateau/ Mogollon Rim and the Sierra Madre Occidental. Our results suggest an allopatric mode of speciation given the near absence of gene flow over time, which resulted in two lineages of unequal population sizes. Speciation likely occurred prior to the Pleistocene, during the aridification of the SW and/or the uplift of the Colorado Plateau, and while these species occupy similar high-elevation niches, they are isolated by xeric conditions found in the intervening low deserts. Furthermore, post-speciation demographics suggest that populations of both lineages were not negatively impacted by climate change throughout the Pleistocene. Finally, our results suggest that at least for this group, where divergence is old and gene flow is low, Bayesian species delimitation performs well. PMID:21627995

  4. ROA's Real time GNSS network and its viability in Alertes-RIM system

    Science.gov (United States)

    Cibeira Urtiaga, Ángel; Gárate, Jorge; Mendoza, Leonor

    2015-04-01

    San Fernando Naval Observatory deployed a Geodetic Continuous GNSS network from the mid nineties. The most of the sites are located in the South of the Iberian Peninsula. Nowadays time series of several years for the most of these sites are available. This is the most risky region in the peninsula due to the confrontation of two tectonic plates, i.e. Euro-Asiatic and African Plates. The former confrontation generated several faults, origin of important earthquakes (e.g. the big earthquake of Lisbon in 1775, whose epicenter was located in the Azores-Gibraltar fault, where Euro-Asiatic and African plates collide). In order to prevent higher aftermaths, the San Fernando Naval Observatory with the University of Cádiz and the University Complutense of Madrid, started to develop an early warning system, based on the study of the P waves, with the result of a prototype known as Alertes system. In early 2014 an improvement of the Alertes-RIM system began, introducing the study of viability of using high frequency geodetic GNSS signals in real time and others, looking for an improvement in the time of response in the previous instants of an earthquake. This project is still on process of development.

  5. Personalized Message Routing Policy in Pervasive eHealth Applications Based on HL7 RIM.

    Science.gov (United States)

    Guizani, Nachoua; Fayn, Jocelyne

    2015-01-01

    The design of relevant message routing strategies that provide reliable communications between different healthcare actors is deemed among one of the most challenging requirements to enhance QoS in eHealth applications. In this paper, we propose a data and context-driven model that aims to support the design of personalized, intelligent and adaptive eHealth message routing policies. Our model is suitably complying with HL7 v3, an international standard for healthcare information exchange. In the proposed model, we highlight the sensitivity of routing services applications to message, source and target ecosystems contextual information. We point out the relevant HL7 Reference Information Model (RIM) elements that are related to our research objective which is to deliver the message to the right healthcare provider with respect to the required delays for message reception, reading and reply, according to the content of the message and to the clinical and social situation of the patient. Moreover, we include AmI to make the routing policy intelligently adaptive to context changes at run-time. PMID:25980880

  6. Fife, a Drosophila Piccolo-RIM homolog, promotes active zone organization and neurotransmitter release.

    Science.gov (United States)

    Bruckner, Joseph J; Gratz, Scott J; Slind, Jessica K; Geske, Richard R; Cummings, Alexander M; Galindo, Samantha E; Donohue, Laura K; O'Connor-Giles, Kate M

    2012-11-28

    Neuronal communication depends on the precisely orchestrated release of neurotransmitter at specialized sites called active zones (AZs). A small number of scaffolding and cytoskeletal proteins comprising the cytomatrix of the active zone (CAZ) are thought to organize the architecture and functional properties of AZs. The majority of CAZ proteins are evolutionarily conserved, underscoring the fundamental similarities in neurotransmission at all synapses. However, core CAZ proteins Piccolo and Bassoon have long been believed exclusive to vertebrates, raising intriguing questions about the conservation of the molecular mechanisms that regulate presynaptic properties. Here, we present the identification of a piccolo-rim-related gene in invertebrates, together with molecular phylogenetic analyses that indicate the encoded proteins may represent Piccolo orthologs. In accordance, we find that the Drosophila homolog, Fife, is neuronal and localizes to presynaptic AZs. To investigate the in vivo function of Fife, we generated a deletion of the fife locus. We find that evoked neurotransmitter release is substantially decreased in fife mutants and loss of fife results in motor deficits. Through morphological analysis of fife synapses, we identify underlying AZ abnormalities including pervasive presynaptic membrane detachments and reduced synaptic vesicle clustering. Our data demonstrate the conservation of a Piccolo-related protein in invertebrates and identify critical roles for Fife in regulating AZ structure and function. These findings suggest the CAZ is more conserved than previously thought, and open the door to a more complete understanding of how CAZ proteins regulate presynaptic structure and function through genetic studies in simpler model systems. PMID:23197698

  7. Bassoon specifically controls presynaptic P/Q-type Ca(2+) channels via RIM-binding protein.

    Science.gov (United States)

    Davydova, Daria; Marini, Claudia; King, Claire; Klueva, Julia; Bischof, Ferdinand; Romorini, Stefano; Montenegro-Venegas, Carolina; Heine, Martin; Schneider, Romy; Schröder, Markus S; Altrock, Wilko D; Henneberger, Christian; Rusakov, Dmitri A; Gundelfinger, Eckart D; Fejtova, Anna

    2014-04-01

    Voltage-dependent Ca(2+) channels (CaVs) represent the principal source of Ca(2+) ions that trigger evoked neurotransmitter release from presynaptic boutons. Ca(2+) influx is mediated mainly via CaV2.1 (P/Q-type) and CaV2.2 (N-type) channels, which differ in their properties. Their relative contribution to synaptic transmission changes during development and tunes neurotransmission during synaptic plasticity. The mechanism of differential recruitment of CaV2.1 and CaV2.2 to release sites is largely unknown. Here, we show that the presynaptic scaffolding protein Bassoon localizes specifically CaV2.1 to active zones via molecular interaction with the RIM-binding proteins (RBPs). A genetic deletion of Bassoon or an acute interference with Bassoon-RBP interaction reduces synaptic abundance of CaV2.1, weakens P/Q-type Ca(2+) current-driven synaptic transmission, and results in higher relative contribution of neurotransmission dependent on CaV2.2. These data establish Bassoon as a major regulator of the molecular composition of the presynaptic neurotransmitter release sites. PMID:24698275

  8. Ciclamato de sódio e rim fetal / Sodium cyclamate and fetal kidney

    Scientific Electronic Library Online (English)

    José Germano Ferraz de, Arruda; Alex Tadeu, Martins; Reinaldo, Azoubel.

    2003-06-01

    Full Text Available O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O ciclamato e a ciclohexilamina, seu p [...] rincipal metabólito, atravessam a barreira placentária em humanos e desse modo podem ser expostos ao feto. O rim de ratos pode ser afetado por elevadas doses de ciclamato de sódio. Estudos sobre efeitos do ciclamato de sódio na espécie humana são necessários, pois, além de poder substituir a sacarose - prejudicial em casos de diabetes ou quando o controle e a redução do peso corporal são essenciais para a saúde dos pacientes - não propicia desenvolvimento de cárie dentária. Abstract in english Cyclamate is used as an artificial non-caloric sweetener in a variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It is present in the formula of products such as sodium and calcium cyclamates and cyclamic acid. Cyclamate and cyclohexylamine, [...] its principal metabolite, can cross the human placenta exposing the fetus. It has been demonstrated in rats that the kidney may be adversely affected by high doses of cyclamate. Studies on the effects of sodium cyclamate in the human species are necessary, because in addition to replacing saccharose - harmful in individuals with diabetes or patients in whom weight reduction and control are essential for health - it does not cause dental caries.

  9. Ciclamato de sódio e rim fetal Sodium cyclamate and fetal kidney

    Directory of Open Access Journals (Sweden)

    José Germano Ferraz de Arruda

    2003-06-01

    Full Text Available O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O ciclamato e a ciclohexilamina, seu principal metabólito, atravessam a barreira placentária em humanos e desse modo podem ser expostos ao feto. O rim de ratos pode ser afetado por elevadas doses de ciclamato de sódio. Estudos sobre efeitos do ciclamato de sódio na espécie humana são necessários, pois, além de poder substituir a sacarose - prejudicial em casos de diabetes ou quando o controle e a redução do peso corporal são essenciais para a saúde dos pacientes - não propicia desenvolvimento de cárie dentária.Cyclamate is used as an artificial non-caloric sweetener in a variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It is present in the formula of products such as sodium and calcium cyclamates and cyclamic acid. Cyclamate and cyclohexylamine, its principal metabolite, can cross the human placenta exposing the fetus. It has been demonstrated in rats that the kidney may be adversely affected by high doses of cyclamate. Studies on the effects of sodium cyclamate in the human species are necessary, because in addition to replacing saccharose - harmful in individuals with diabetes or patients in whom weight reduction and control are essential for health - it does not cause dental caries.

  10. Radiation thermo-chemical models of protoplanetary disks I. Hydrostatic disk structure and inner rim

    CERN Document Server

    Woitke, Peter; Thi, Wing-Fai

    2009-01-01

    This paper introduces a new disk code, called ProDiMo, to calculate the thermo-chemical structure of protoplanetary disks and to interpret gas emission lines from UV to sub-mm. We combine frequency-dependent 2D dust continuum radiative transfer, kinetic gas-phase and UV photo-chemistry, ice formation, and detailed non-LTE heating & cooling balance with the consistent calculation of the hydrostatic disk structure. We include FeII and CO ro-vibrational line heating/cooling relevant for the high-density gas close to the star, and apply a modified escape probability treatment. The models are characterized by a high degree of consistency between the various physical, chemical and radiative processes, where the mutual feedbacks are solved iteratively. In application to a T Tauri disk extending from 0.5AU to 500AU, the models are featured by a puffed-up inner rim and show that the dense, shielded and cold midplane (z/r<0.1, Tg~Td) is surrounded by a layer of hot (5000K) and thin (10^7 to 10^8 cm^-3) atomic ga...

  11. Resonance Ionization Mass Spectrometry (RIMS) with Pulsed and CW-Lasers on Plutonium

    International Nuclear Information System (INIS)

    The detection of long-lived plutonium isotopes in ultra-trace amounts by resonance ionization mass spectrometry (RIMS) is a well-established routine method. Detection limits of 106 to 107 atoms and precise measurements of the isotopic composition have been achieved. In this work multi-step resonance ionization of plutonium atoms has been performed with tunable lasers having very different output intensities and spectral properties. In order to compare different ways for the resonance ionization of plutonium broadband pulsed dye and titanium:sapphire lasers as well as narrow-band cw-diode and titanium:sapphire lasers have been applied for a number of efficient excitation schemes. It has been shown, that for identical excitation schemes the optical isotope selectivity can be improved by using cw-lasers (bandwidths 2 GHz). Pulsed and cw-laser systems have been used simultaneously for resonance ionization enabling direct comparisons of pulsed and continuous ionization processes. So far, a three-step, three-color laser excitation scheme has been proven to be most practical in terms of efficiency, selectivity and laser wavelengths. Alternatively a newly discovered three-step, two-color excitation scheme which includes a strong two-photon transition from an excited state into a high-lying autoionizing state yields similar ionization efficiencies. This two-photon transition was characterized with respect to saturation behavior and line width.

  12. Impact of ionic liquids on europium and americium extraction by an upper rim phosphorylated calixarene

    International Nuclear Information System (INIS)

    The solvent extraction of europium and americium using the calixarene 5,11,17,23-tetrakis[dipropylphosphinylmethyl] 25,26,27,28-tetrapropoxycalix[4]arene (conical conformation) in the presence of ionic liquids with different natures was studied. It was shown that upper rim phosphorylated calixarene is able to extract europium and americium from nitric acid to dichloroethane by forming a 1:1 complex without the addition of ionic liquids. The distribution coefficients of americium are higher than those of europium in this case, but the isolation degrees of both elements are insufficient for this system to be useful in extraction technologies. The addition of the ionic liquid trihexyl(tetradecyl)phosphonium hexafluorophosphate increases the europium distribution coefficient by values ranging from twofold to more than two orders of magnitude at ionic liquid concentrations of 1 and 50 %, respectively. The values of the distribution coefficients for americium are increased by approximately 25-fold after a 50 % addition of the ionic liquid. (author)

  13. Resonance Ionization Mass Spectrometry (RIMS): applications in spectroscopy and chemical dynamics

    International Nuclear Information System (INIS)

    Resonance ionization is a photophysical process wherein electromagnetic radiation is used to ionize atoms, molecules, transient species, etc., by exciting them through their quantum states. The number of photons required to ionize depends on the species being investigated and energy of the photon. Once a charged particle is produced, it is easy to detect it with high efficiency. With the advent of narrow band high power pulsed and cw tunable dye lasers, it has blossomed into a powerful spectroscopic and analytical technique, commonly known as resonance ionization spectroscopy (RIS)/resonance enhanced multiphoton ionization (REMPI). The alliance of resonance ionization with mass spectrometry has grown into a still more powerful technique, known as resonance ionization mass spectrometry (RIMS), which has made significant contributions in a variety of frontier areas of research and development, such as spectroscopy, chemical dynamics, analytical chemistry, cluster science, surface science, radiochemistry, nuclear physics, biology, environmental science, material science, etc. In this article, we shall describe the application of resonance ionization mass spectrometry to spectroscopy of uranium and chemical dynamics of polyatomic molecules

  14. UPb ages of zircon rims: A new analytical method using the air-abrasion technique

    Science.gov (United States)

    Aleinikoff, J.N.; Winegarden, D.L.; Walter, M.

    1990-01-01

    We present a new technique for directly dating, by conventional techniques, the rims of zircons. Several circumstances, such as a xenocrystic or inherited component in igneous zircon and metamorphic overgrowths on igneous cores, can result in grains with physically distinct age components. Pneumatic abrasion has been previously shown by Krogh to remove overgrowths and damaged areas of zircon, leaving more resistant and isotopically less disturbed parts available for analysis. A new abrader design, which is capable of very gently grinding only tips and interfacial edges of even needle-like grains, permits easy collection of abraded material for dating. Five examples demonstrate the utility of the "dust-collecting" technique, including two studies that compare conventional, ion microprobe and abrader data. Common Pb may be strongly concentrated in the outermost zones of many zircons and this Pb is not easily removed by leaching (even in weak HF). Thus, the benefit of removing only the outermost zones (and avoiding mixing of age components) is somewhat compromised by the much higher common Pb contents which result in less precise age determinations. A very brief abrasion to remove the high common Pb zones prior to collection of material for dating is selected. ?? 1990.

  15. Mixed multiplicities for arbitrary ideals and generalized Buchsbaum-Rim multiplicities

    International Nuclear Information System (INIS)

    We introduce first the notion of mixed multiplicities for arbitrary ideals in a local d-dimensional noetherian ring (A, m) which, in some sense, generalizes the concept of mixed multiplicities for m-primary ideals. We also generalize Teissier's Product Formula for a set of arbitrary ideals. We also extend the notion of the Buchsbaum-Rim multiplicity (in short, we write BR-multiplicity) of a submodule of a free module to the case where the submodule no longer has finite colength. For a submodule M of Ap we introduce a sequence eBRk(M), k = 0,...,d + p - 1 which in the ideal case coincides with the multiplicity sequence c0(I, A),...,cd(I, A) defined for an arbitrary ideal I of A by Achilles and Manaresi in [AM]. In case that M has finite colength in Ap and it is totally decomposable we prove that our BR-multiplicity sequence essentially falls into the standard BR-multiplicity of M. (author)

  16. Ascaridíase das vias urinárias: um caso de penetração de Ascaris lumbricoides através do rim

    Directory of Open Access Journals (Sweden)

    Mario Caymmi Gomes

    1977-10-01

    Full Text Available Uma criança de 2 anos com desnutrição grave e infestação intestinal maciça por Ascaris lumbricoides, apresentou como complicação, documentada em necrópsia, a migração de vermes adultos para a cavidade peritonial e penetração aberrante de dois parasitos através do rim esquerdo. Os Ascaris ficaram alojados no sistema pielo-ureteral, determinando grave infecção purulenta e obstrução ureteral. Esta complicação demonstra a capacidade agressiva de vermes erráticos na cavidade peritonial, com possibilidade de perfurar mesmo uma víscera sólida. São comentados os fatores que facilitaram a migração dos vermes por aqueles órgãos.The author reports an autopsy case of a two year old child with massive intestinal ascariasis and malnutrition, presenting the migration of two adult Ascaris lumbricoides through the left kidney into the pyelo-ureteral system. As a result she developed acute pyelonephritis and ureteral obstruction. Previously the worms left the intestine into the peritoneal cavity (lesser sac through a duodenal cleft. Factors contributing to the migration of the roundworms by those pathways are discussed.

  17. Ascaridíase das vias urinárias: um caso de penetração de Ascaris lumbricoides através do rim

    Scientific Electronic Library Online (English)

    Mario Caymmi, Gomes.

    1977-10-01

    Full Text Available Uma criança de 2 anos com desnutrição grave e infestação intestinal maciça por Ascaris lumbricoides, apresentou como complicação, documentada em necrópsia, a migração de vermes adultos para a cavidade peritonial e penetração aberrante de dois parasitos através do rim esquerdo. Os Ascaris ficaram alo [...] jados no sistema pielo-ureteral, determinando grave infecção purulenta e obstrução ureteral. Esta complicação demonstra a capacidade agressiva de vermes erráticos na cavidade peritonial, com possibilidade de perfurar mesmo uma víscera sólida. São comentados os fatores que facilitaram a migração dos vermes por aqueles órgãos. Abstract in english The author reports an autopsy case of a two year old child with massive intestinal ascariasis and malnutrition, presenting the migration of two adult Ascaris lumbricoides through the left kidney into the pyelo-ureteral system. As a result she developed acute pyelonephritis and ureteral obstruction. [...] Previously the worms left the intestine into the peritoneal cavity (lesser sac) through a duodenal cleft. Factors contributing to the migration of the roundworms by those pathways are discussed.

  18. Structural studies of eight bright rimmed clouds in the southern hemisphere

    CERN Document Server

    Sharma, Saurabh; Borissova, J; Ojha, D K; Ivanov, V D; Ogura, K; Kobayashi, N; Kurtev, R; Gopinathan, M; Yadav, Ram Kesh

    2016-01-01

    We carried out deep and wide-field near- and mid-infrared observations for a sample of 8 bright-rimmed clouds (BRCs). Supplemented with the $Spitzer$ archival data, we have identified and classified 44 to 433 young stellar objects (YSOs) associated with these BRCs. The Class I sources are generally located towards the places with higher extinction and are relatively closer to each other than the Class II sources, confirming that the young protostars are usually found in regions having denser molecular material. On the other hand the comparatively older population, Class II objects, are more randomly found throughout the regions, which can be due to their dynamical evolution. Using the minimal sampling tree analyses, we have extracted 13 stellar cores of 8 or more members, which contains 60\\% of the total YSOs. The typical core is $\\sim$0.6 pc in radii and somewhat elongated (aspect ratio of 1.45), of relatively low stellar density (surface density 60 pc$^{-2}$), consisting of a small (35) number of YSOs of re...

  19. H$_2$O maser emission from bright rimmed clouds in the northern hemisphere

    CERN Document Server

    Valdettaro, R; Brand, J; Cesaroni, R

    2005-01-01

    We report the results of a multi-epoch survey of water maser observations at 22.2 GHz with the Medicina radiotelescope from 44 bright rimmed clouds (BRCs) of the northern hemisphere identified by Sugitani et al. (1989) as potential sites of star formation. The data span 16 years of observations and allow to draw conclusions about the maser detection rate in this class of objects. In spite of the relatively high far-infrared luminosities of the embedded sources ($L_{\\rm FIR}\\ga 10^2$ L$_\\odot$), H$_2$O maser emission was detected towards three globules only. Since the occurrence of water masers is higher towards bright IRAS sources, the lack of frequent H$_2$O maser emission is somewhat surprising if the suggestion of induced intermediate- and high-mass star formation within these globules is correct. The maser properties of two BRCs are characteristic of exciting sources of low-mass, while the last one (BRC~38) is consistent with an intermediate-mass object. We argue that most BRCs host young stellar objects ...

  20. Bone health in adolescence

    Directory of Open Access Journals (Sweden)

    Oya

    2011-03-01

    Full Text Available The skeleton undergoes rapid change with respect to growth, modeling and remodeling processes in adolescence. Consequently, the effects of factors that affect bone health positively or negatively can be greater. Between 40% and 60% of, peak bone mass which serves as the bone bank for life, is accrued during adolescence. Lifetime risk of osteoporosis and fracture may be increased if optimal peak bone mass cannot be reached.Accrual of peak bone mass is affected by unmodifiable intrinsic factors and less important extrinsic factors. Higher body mass index and body fat and lower dietary calcium intake increase fracture risk in healthy adolescents. Bone mass was found to be 5% to 10% lower in adolescents with fracture than their peers. Adequate nutrition in amount and composition and life style factors are important for skeletal health. While diets rich in saturated fats and refined sugars and lower in protein may be detrimental to bone health, optimal quantities of polyunsaturated fatty acids and complex carbohydrates may be beneficial to bone health. Dietary calcium and vitamin D are key factors in promoting bone health and preventing bone loss. Phosphorus and magnesium as well as other elements and especially vitamin C and K have been shown to play important roles in bone health. While weight bearing regular exercise and a healthy bodyweight are beneficial to bone health, alcohol consumption and smoking contribute to poor bone health. Adolescence may serve as a period of opportunity for reduction of the incidence of osteoporosis in adulthood through implication of effective intervention strategies. (Turk Arch Ped 2011; 46 Suppl: 54-8

  1. Monostotic Paget Disease of Bone or Bone Metastasis?

    Directory of Open Access Journals (Sweden)

    Özlem Erdem Süer

    2008-06-01

    Full Text Available Paget’s disease of bone is a metabolic bone disorder with male predominance and characterized by increased bone turnover. Recent literature indicates a reduction in incidence and severity. We report a 55 years old female patient who was admitted with knee pain, and whose pelvis x-ray demonstrated pathological features. She was investigated with preliminary diagnoses of Paget’s disease of bone, osteosclerotic bone metastasis and primary bone tumor. Histopathological examination of bone biopsy confirmed Paget’s disease of bone and Paget’s disease of bone is reviewed. Turk J Phys Med Rehab 2008;54:73-6

  2. Development of a thermal conductivity correlation for the pellet rim region and its application to the analysis of behaviour of high burnup fuel

    International Nuclear Information System (INIS)

    A thermal conductivity correlation has been proposed which can be applied to high burnup fuel by considering the degradation of thermal conductivity with burnup at pellet rim due to very high porosity. In addition, a correlation has been developed that can estimate the porosity of rim region as a function of rim burnup under the assumptions that all the produced fission gases are retained in the rim porosity and threshold pellet average burnup required for the formation of rim region is 40 MWD/kgU. Rim width is correlated to rim burnup using measured data. For the RISO experimental data obtained at pellet average burnup of 43.5 MWD/kgU for three linear heat generation rates of 30, 35 and 40 kW/m, radial temperature distributions were calculated using the present correlation and compared with the measured ones. This comparison shows that the present correlation gives the best agreement with the measured data when it is combined with HALDEN's correlation for thermal conductivity which considers its degradation with burnup, another comparison with HALDEN's measured fuel centerline temperature as a function of burnup at 25 kW/m up to about 44 MWD/kgU also suggests that the present correlation yields the best agreement when it is combined with HALDEN's thermal conductivity. (author)

  3. Bone tumors: Nursing care

    International Nuclear Information System (INIS)

    Bone tumors represent approximately 5% of childhood malignancies. osteosarcoma is the primary malignant bone tumor, accounting for 60% of cancer with peak incidence in the 2nd decade of life. Ewing's sarcoma is the second most common bone cancer with peak at a slightly younger age. This presentation discusses similarities and differences in the diagnosis and treatment of these two malignancies. Diagnostic procedures include plain radiographs, CT and MRI of the primary site, plain x-ray and CT of the chest, bone scan, and biopsy of the primary tumor. For patients diagnosed with Ewing's sarcoma, a bone marrow aspirate and biopsy will also be required. Our current approach to the treatment of bone tumors includes preoperative combination chemotherapy and en bloc surgical removal of the tumor followed by postoperative chemotherapy. In the case of Ewing's sarcoma, radiation therapy may be employed in addition to surgery, if margins are questionable of instead of surgery, if the tumor is not resectable

  4. Deep Drawing for high LDR by a new Hydro-rim Forming Process with Differential Temperature- Analysis and Experiments

    Science.gov (United States)

    Simon, Y. Ben; Tirosh, J.; Rubinski, Ludmila

    2005-08-01

    The purpose of this study is to analyze and test a possible increase of the Limit Drawing Ratio (LDR) in Deep Drawing by Hydro-rim process (a certain subset of the classical Hydroforming) which includes the newly differential temperature effect. The idea is to facilitate the plastic flow by local heating along the flange and to cool the area where strength is needed. The suggested analysis is based on the dual bounds approach (upper and lower bounds simultaneously) using the highly versatile Johnson-Cook constitutive material model. The advantage of combined high hydraulic pressure (about 1000 bar) with relatively high blank temperature (with magnitude of about one third the melting temperature of the considered material) in the same operation is discussed. Emphasis is given to the rule of blank temperature difference (between the flange and the wall of the product) conjugate with optimal hydro rim pressure in increasing the limit drawing ratio of the products (Aluminum, Copper and various Steels).

  5. A world perspective of the back-end fuel cycle and its significance for the Pacific rim countries

    International Nuclear Information System (INIS)

    There are currently two options available for the management of irradiated fuel. The first is reprocessing and recycle, and the second is the direct disposal of fuel following some form of storage and treatment. Interim storage is not an option but a deferral of the decision of which option to take. This paper identifies the major issues which are important in deciding on which option to follow and examines the possible implications for Pacific Rim Countries. Reprocessing and direct disposal are likely to remain complementary technologies for the foreseeable future, but it is the strategic significance of recycle that beckons with reduced dependence on energy imports within the Pacific Rim. This is challenged only by the perceptions of risks of and related attitudes to, nuclear weapons proliferation. This latter is a matter that can only be resolved at political level with international consensus

  6. AN INVESTIGATION OF THE TYPE M MORPHOLOGICAL STRUCTURE OF IC59: A NEW MODEL FOR BRIGHT RIM CLOUDS?

    International Nuclear Information System (INIS)

    We report the results from a smoothed particle hydrodynamics simulation designed to model recent observational data on the nebula and Bright Rim Cloud IC59. We further examine, in the context of radiative-driven implosion (RDI) models, the possible formation mechanisms of the morphological structure of IC59. The results of the simulation reveal the existence of a new, fourth morphological state for Bright Rim Clouds (BRCs)-which we propose to call a Type M BRC morphology. We discuss the necessary conditions for the appearance of Type M BRCs, based on analytical and numerical simulations. The simulated physical properties from our model are consistent with the available observations of IC59. We further show that the prospect of RDI triggered star formation in all Type M BRCs is not supported by the simulations.

  7. A Novel Mutation of the GNE Gene in Distal Myopathy with Rimmed Vacuoles: A Case with Inflammation.

    Science.gov (United States)

    Tanboon, Jantima; Rongsa, Kanjana; Pithukpakorn, Manop; Boonyapisit, Kanokwan; Limwongse, Chanin; Sangruchi, Tumtip

    2014-01-01

    Distal myopathy with rimmed vacuoles (DMRV) is an autosomal recessive or sporadic early adult-onset myopathy caused by mutations in the UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase (GNE) gene. Characteristic pathologic features of DMRV are rimmed vacuoles on muscle biopsy and tubulofilamentous inclusion in ultrastructural study. Presence of inflammation in DMRV is unusual. We report a sporadic case of DMRV in a 40-year-old Thai man who presented with slowly progressive distal muscle weakness. Gene analysis revealed a compound heterozygous mutation of the GNE gene including a novel mutation c.1057A>G (p.K353E) and a known mutation c.2086G>A (p.V696M). The latter is the most common mutation in Thai DMRV patients. The muscle pathology was compatible with DMRV except for focal inflammation. PMID:24707269

  8. Deep Drawing for high LDR by a new Hydro-rim Forming Process with Differential Temperature- Analysis and Experiments

    International Nuclear Information System (INIS)

    The purpose of this study is to analyze and test a possible increase of the Limit Drawing Ratio (LDR) in Deep Drawing by Hydro-rim process (a certain subset of the classical Hydroforming) which includes the newly differential temperature effect. The idea is to facilitate the plastic flow by local heating along the flange and to cool the area where strength is needed. The suggested analysis is based on the dual bounds approach (upper and lower bounds simultaneously) using the highly versatile Johnson-Cook constitutive material model. The advantage of combined high hydraulic pressure (about 1000 bar) with relatively high blank temperature (with magnitude of about one third the melting temperature of the considered material) in the same operation is discussed. Emphasis is given to the rule of blank temperature difference (between the flange and the wall of the product) conjugate with optimal hydro rim pressure in increasing the limit drawing ratio of the products (Aluminum, Copper and various Steels)

  9. Conceptual Study on New Isotope Analysis Technique with Resonance Ionization Mass Spectrometry Using Inductively Coupled Plasma as an Atomic Source (ICP-RIMS)

    International Nuclear Information System (INIS)

    We have proposed the novel isotope analysis technique with Resonance Ionization Mass Spectrometry using Inductively Coupled Plasma as an atomic source (ICP-RIMS). Each component of ICP-RIMS is conceptually designed. We conclude that the orthogonal acceleration time-of-flight mass spectrometer (oa-TOF-MS) driven by a high-repetition-rate pulsed laser would be suitable system for ICP-RIMS. We, additionally, suggest that the first vacuum stage of the vacuum interface, which is between the sampling and skimmer cones, is desired to maintain as low pressure as possible in order to suppress the Doppler broadening and to skim the supersonic jet effectively.

  10. Nanocomposites and bone regeneration

    Science.gov (United States)

    James, Roshan; Deng, Meng; Laurencin, Cato T.; Kumbar, Sangamesh G.

    2011-12-01

    This manuscript focuses on bone repair/regeneration using tissue engineering strategies, and highlights nanobiotechnology developments leading to novel nanocomposite systems. About 6.5 million fractures occur annually in USA, and about 550,000 of these individual cases required the application of a bone graft. Autogenous and allogenous bone have been most widely used for bone graft based therapies; however, there are significant problems such as donor shortage and risk of infection. Alternatives using synthetic and natural biomaterials have been developed, and some are commercially available for clinical applications requiring bone grafts. However, it remains a great challenge to design an ideal synthetic graft that very closely mimics the bone tissue structurally, and can modulate the desired function in osteoblast and progenitor cell populations. Nanobiomaterials, specifically nanocomposites composed of hydroxyapatite (HA) and/or collagen are extremely promising graft substitutes. The biocomposites can be fabricated to mimic the material composition of native bone tissue, and additionally, when using nano-HA (reduced grain size), one mimics the structural arrangement of native bone. A good understanding of bone biology and structure is critical to development of bone mimicking graft substitutes. HA and collagen exhibit excellent osteoconductive properties which can further modulate the regenerative/healing process following fracture injury. Combining with other polymeric biomaterials will reinforce the mechanical properties thus making the novel nano-HA based composites comparable to human bone. We report on recent studies using nanocomposites that have been fabricated as particles and nanofibers for regeneration of segmental bone defects. The research in nanocomposites, highlight a pivotal role in the future development of an ideal orthopaedic implant device, however further significant advancements are necessary to achieve clinical use.

  11. SILICON AND BONE HEALTH

    OpenAIRE

    JUGDAOHSINGH, R.

    2007-01-01

    Low bone mass (osteoporosis) is a silent epidemic of the 21st century, which presently in the UK results in over 200,000 fractures annually at a cost of over one billion pounds. Figures are set to increase worldwide. Understanding the factors which affect bone metabolism is thus of primary importance in order to establish preventative measures or treatments for this condition. Nutrition is an important determinant of bone health, but the effects of the individual nutrients and minerals, other...

  12. Human prostatic acid phosphatase directly stimulates collagen synthesis and alkaline phosphatase content of isolated bone cells

    International Nuclear Information System (INIS)

    Human prostatic acid phosphatase (hPAP) directly enhances the differentiated characteristics of isolated bone cells in vitro. This enzyme, when added to cell cultures for 24 h in vitro stimulates collagen synthesis and the production of alkaline phosphatase. The effects are dose dependent, with statistically significant effects occurring from 0.1-100 nM hPAP. Concentrations higher than 100 nM do not evoke greater effects. The maximal effect of hPAP occurs between 12 and 24 h of exposure. The cells stimulated to the greatest degree are osteoprogenitor cells and osteoblasts. Fibroblasts isolated from the same tissue show a lesser sensitivity to hPAP. hPAP has no detectable effect on cell proliferation, as measured by radiolabeled thymidine incorporation or total DNA synthesis. None of the observations reported in this work can be attributed to contaminating proteins in the hPAP preparation. hPAP was radiolabeled with 125I and was used for affinity binding and cross-linking studies. Scatchard analysis of specific binding indicated the presence of 1.0 X 10(5) high affinity binding sites/cell, with a Kd of 6.5 nM. Cross-linking studies demonstrated the presence of one 320-kDa binding complex. The pH profile and kinetic determinations of Km and maximum velocity for hPAP were similar to those previously reported, except for the finding of positive cooperativity of the substrate with the enzyme under the conditions of our assay. We believe that the direct stimulation of bone-forming cells by hPAP may contribute to the sclerotic nature of skeletal bone around sites of neoplastic prostatic metastases and that the effect of the enzyme is probably mediated by a plasma membrane receptor

  13. Genetic enhancement of cognition in a kindred with cone–rod dystrophy due to RIMS1 mutation

    OpenAIRE

    Sisodiya, S.M.; Thompson, P.J.; Need, A; Harris, S.E.; Weale, M.E.; Wilkie, S. E.; Michaelides, M; Free, S.L.; Walley, N.; Gumbs, C.; Gerrelli, D; Ruddle, P.; Whalley, L.J.; Starr, J M; Hunt, D M

    2007-01-01

    Background: The genetic basis of variation in human cognitive abilities is poorly understood. RIMS1 encodes a synapse active- zone protein with important roles in the maintenance of normal synaptic function: mice lacking this protein have greatly reduced learning ability and memory function.Objective: An established paradigm examining the structural and functional effects of mutations in genes expressed in the eye and the brain was used to study a kindred with an inherited retinal dystrophy d...

  14. A tale of two cores: Triggered massive star formation in the bright-rimmed cloud SFO 75

    OpenAIRE

    Urquhart, J. S.; Thompson, M. A.; Morgan, L.K.; Pestalozzi, M. R.; White, Glenn J.; Muna, D. N.

    2007-01-01

    Context. Bright-rimmed clouds (BRCs) are isolated molecular clouds located on the edges of evolved HII regions. Star formation within the BRCs may have been triggered through the propagation of photoionisation-induced shocks driven by the expansion of the HII region. Aims. The main focus of this paper is to investigate the current level of star formation within one of these clouds and evaluate to what extent, if any, star formation may have been triggered. Methods. We present a detailed multi...

  15. Matsu Cultural Heritage and Its Conservation in Bohai Rim - Case Study on the Hall of Fujian in Yantai

    Science.gov (United States)

    Yao, S.

    2015-08-01

    Since the Yuan Dynasty, the belief of Matsu had started to spread from the birthplace to the northern coastal areas in China. Matsu worship developed to the pinnacle with the official promotion on account of the government's dependence on grain transported by sea since the mid-Qing Dynasty. A large amount of Matsu temples emerged in coastal cities of Bohai Rim where it still keeps a large number of them until now. It has much relationship between the spread of Matsu culture and the flow of Fujian population. It was one of the main building way that the Matsu temples attached to the local hall of Fujian in Bohai Rim. The Hall of Fujian in Yantai, Which was built with materials taken from Fujian, in the feature of traditional architectural style from QuanZhou, is very different from the local building style of Yantai. This case indicates that maritime culture of the south area had spread and developed in the north areas under the promotion of the population flow and the economic transaction. The essay introduces briefly about the development of Matsu culture in Bohai Rim and takes the case study of the Hall of Fujian in Yantai analyzing its causes and features, and the value as Matsu heritage. Then the paper will discuss the conservation of Matsu culture mere include the tangible and the intangible culture heritage around the origin area, the heritages of the spread area also have the same importance significance. With the evolution of the society, it calls urgent attention and protection of Matsu culture in Bohai Rim.

  16. Homothorax and Extradenticle alter the transcription factor network in Drosophila ommatidia at the dorsal rim of the retina

    OpenAIRE

    Wernet, Mathias F.; Desplan, Claude

    2014-01-01

    A narrow band of ommatidia in the dorsal periphery of the Drosophila retina called the dorsal rim area (DRA) act as detectors for polarized light. The transcription factor Homothorax (Hth) is expressed in DRA inner photoreceptors R7 and R8 and is both necessary and sufficient to induce the DRA fate, including specialized morphology and unique Rhodopsin expression. Hth expression is the result of Wingless (Wg) pathway activity at the eye margins and restriction to the dorsal eye by the selecto...

  17. RC-IAL: linhagem celular contínua de rim de coelho - características e substrato para replicação de vírus

    OpenAIRE

    Cruz Aurea Silveira; Figueiredo Cristina Adelaide; Barbosa Maria Luisa; Martinez Clelia Helena de O.; Salles-Gomes Luís Florêncio de

    1992-01-01

    Uma linhagem celular de rim de coelho (denominada RC-IAL), que foi isolada em 1976, e que atualmente está na 150ª passagem, teve suas características analisadas. As células apresentaram morfologia semelhante aos fibroblastos desde o início de seu cultivo. A proporção de crescimento celular não se alterou desde seu isolamento, com uma eficiência de clonagem ao redor de 9%. A linhagem mostrou crescimento dependente de ancoragem, e a análise cromossômica apresentou o número modal da espécie com ...

  18. Hypercalciuric Bone Disease

    Science.gov (United States)

    Favus, Murray J.

    2008-09-01

    Hypercalciuria plays an important causal role in many patients with calcium oxalate (CaOx) stones. The source of the hypercalciuria includes increased intestinal Ca absorption and decreased renal tubule Ca reabsorption. In CaOx stone formers with idiopathic hypercalciuria (IH), Ca metabolic balance studies have revealed negative Ca balance and persistent hypercalciuria in the fasting state and during low dietary Ca intake. Bone resorption may also contribute to the high urine Ca excretion and increase the risk of bone loss. Indeed, low bone mass by DEXA scanning has been discovered in many IH patients. Thiazide diuretic agents reduce urine Ca excretion and may increase bone mineral density (BMD), thereby reducing fracture risk. Dietary Ca restriction that has been used unsuccessfully in the treatment of CaOx nephrolithiasis in the past may enhance negative Ca balance and accelerate bone loss. DEXA scans may demonstrate low BMD at the spine, hip, or forearm, with no predictable pattern. The unique pattern of bone histologic changes in IH differs from other causes of low DEXA bone density including postmenopausal osteoporosis, male hypogonadal osteoporosis, and glucocorticoid-induced osteoporosis. Hypercalciuria appears to play an important pathologic role in the development of low bone mass, and therefore correction of urine Ca losses should be a primary target for treatment of the bone disease accompanying IH.

  19. Toxicokinetics of bone lead.

    OpenAIRE

    Rabinowitz, M. B.

    1991-01-01

    This article discusses bone as a source of lead to the rest of the body and as a record of past lead exposure. Bone lead levels generally increase with age at rates dependent on the skeletal site and lead exposure. After occupational exposure, the slow decline in blood lead, a 5- to 19-year half-life, reflects the long skeletal half-life. Repeated measurements of bone lead demonstrate the slow elimination of lead from bone. Stable isotope ratios have revealed many details of skeletal uptake a...

  20. Parosteal aneurysmal bone cyst?

    Science.gov (United States)

    Meohas, Walter; de Sá Lopes, Ana Cristina; da Silveira Möller, João Victor; Barbosa, Luma Duarte; Oliveira, Marcelo Bragança dos Reis

    2015-01-01

    The incidence of aneurysmal bone cysts is 0.14 cases per 100,000 individuals. Parosteal aneurysmal bone cysts are the least prevalent subtype and represent 7% of all aneurysmal bone cysts. We present the case of a 38-year-old male patient with pain and bulging in his right arm for eight months. He had previously been diagnosed as presenting giant-cell tumor, but his slides were reviewed and his condition was then diagnosed as parosteal aneurysmal bone cyst. The patient was treated with corticosteroid and calcitonin infiltration into the lesion and evolved with clinical and radiological improvement within the first five weeks after the operation. PMID:26535209

  1. Effects of biodegradation on oil and gas field PVT properties and the origin of oil rimmed gas accumulations

    Energy Technology Data Exchange (ETDEWEB)

    Larter, S. [Newcastle Univ. (United Kingdom). NRG Petroleum Group; Calgary Univ., AB (Canada); Primio, R. di [Norsk Hydro, Bergen (Norway); Geoforschungzentrum Potsdam (Germany)

    2005-02-01

    Dry gas overlying biodegraded oil rims is a common occurrence in the North Sea oil rimmed gas accumulations (ORGAs) and elsewhere in the world. Wet gas biodegradation occurs in Troll, Frigg, Balder and other ORGAs, with propane preferentially degraded over ethane, resulting in gases becoming dryer and oils heavier. We apply several models of biodegradation and compositional change to examine the effect of biodegradation on the physical properties and phase behaviour of degraded oils and compare the predicted results with data from real degraded oils. Several models, including gas biodegradation, gas cap compression and later interaction of undersaturated oil with dry gas caps can account for the ca. 10 m oil rim presence. Wet gas and oil degradation alone and divergent oil and gas physical properties during biodegradation can also account for the oil legs and dry gas caps. All the models rely on biodegradation of both oil and gas, which not only affects the chemical composition but also dramatically affects reservoir engineering properties such as saturation pressure, GOR and Bo. ORGAs seem to represent altered oil or gas accumulations where the heavy oil and dry gas are in equilibrium and are related. Classical admixed biogenic gas or high maturity origin for the dry gas are not needed to account for these accumulations though methane addition to the accumulations during oil biodegradation may sometimes be a dominant process. (Author)

  2. A tale of two cores: Triggered massive star formation in the bright-rimmed cloud SFO 75

    CERN Document Server

    Urquhart, J S; Morgan, L K; Pestalozzi, M R; White, G J; Muna, D N; White, Glenn J.

    2007-01-01

    Abridged: We present a detailed multi-wavelength study of the bright-rimmed cloud SFO 75, including 1.3cm and 1.2mm continuum, and 13CO and ammonia spectral line observations. The 13CO and 1.2 mm emission reveals the presence of a dense core located behind the bright rim of the cloud which is approximately coincident with that of the IRAS point source. From an analysis of the IRAS and 1.2mm fluxes we derive a dust temperature of ~30 K, a luminosity of 1.6x10^4 L\\odot and estimate the core mass to be ~570 M\\odot. The higher resolution ammonia observations resolve the 1.2mm core into two distinct cores, one directly behind the cloud's rim (Core A) and the second located slightly farther back (Core B). Comparing the morphology of Core A with that of the photon-dominated region and ionised boundary layer leaves little doubt that it is being strongly affected by the ionisation front. 2MASS and GLIMPSE archive data which reveal a small cluster of three deeply embedded high- and intermediate-mass young stellar objec...

  3. EFFECTS OF MAGNETIC FIELD AND FAR-ULTRAVIOLET RADIATION ON THE STRUCTURES OF BRIGHT-RIMMED CLOUDS

    Energy Technology Data Exchange (ETDEWEB)

    Motoyama, Kazutaka [National Institute of Informatics, 2-1-2 Hitotsubashi, Chiyoda-ku, Tokyo 101-8430 (Japan); Umemoto, Tomofumi [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 191-8588 (Japan); Shang, Hsien; Hasegawa, Tatsuhiko, E-mail: motoyama@nii.ac.jp [Institute of Astronomy and Astrophysics, Academia Sinica, Taipei 106, Taiwan (China)

    2013-03-20

    The bright-rimmed cloud SFO 22 was observed with the 45 m telescope of Nobeyama Radio Observatory in the {sup 12}CO (J = 1-0), {sup 13}CO (J = 1-0), and C{sup 18}O (J = 1-0) lines, where well-developed head-tail structure and small line widths were found. Such features were predicted by radiation-driven implosion models, suggesting that SFO 22 may be in a quasi-stationary equilibrium state. We compare the observed properties with those from numerical models of a photoevaporating cloud, which include effects of magnetic pressure and heating due to strong far-ultraviolet (FUV) radiation from an exciting star. The magnetic pressure may play a more important role in the density structures of bright-rimmed clouds than the thermal pressure that is enhanced by the FUV radiation. The FUV radiation can heat the cloud surface to near 30 K; however, its effect is not enough to reproduce the observed density structure of SFO 22. An initial magnetic field of 5 {mu}G in our numerical models produces the best agreement with the observations, and its direction can affect the structures of bright-rimmed clouds.

  4. EFFECTS OF MAGNETIC FIELD AND FAR-ULTRAVIOLET RADIATION ON THE STRUCTURES OF BRIGHT-RIMMED CLOUDS

    International Nuclear Information System (INIS)

    The bright-rimmed cloud SFO 22 was observed with the 45 m telescope of Nobeyama Radio Observatory in the 12CO (J = 1-0), 13CO (J = 1-0), and C18O (J = 1-0) lines, where well-developed head-tail structure and small line widths were found. Such features were predicted by radiation-driven implosion models, suggesting that SFO 22 may be in a quasi-stationary equilibrium state. We compare the observed properties with those from numerical models of a photoevaporating cloud, which include effects of magnetic pressure and heating due to strong far-ultraviolet (FUV) radiation from an exciting star. The magnetic pressure may play a more important role in the density structures of bright-rimmed clouds than the thermal pressure that is enhanced by the FUV radiation. The FUV radiation can heat the cloud surface to near 30 K; however, its effect is not enough to reproduce the observed density structure of SFO 22. An initial magnetic field of 5 ?G in our numerical models produces the best agreement with the observations, and its direction can affect the structures of bright-rimmed clouds.

  5. Radiation thermo-chemical models of protoplanetary discs. III. Impact of inner rims on Spectral Energy Distributions

    CERN Document Server

    Thi, Wing-Fai; Kamp, Inga

    2010-01-01

    We study the hydrostatic density structure of the inner disc rim around HerbigAe stars using the thermo-chemical hydrostatic code ProDiMo. We compare the Spectral Energy Distributions (SEDs) and images from our hydrostatic disc models to that from prescribed density structure discs. The 2D continuum radiative transfer in ProDiMo includes isotropic scattering. The dust temperature is set by the condition of radiative equilibrium. In the thermal-decoupled case the gas temperature is governed by the balance between various heating and cooling processes. The gas and dust interact thermally via photoelectrons, radiatively, and via gas accommodation on grain surfaces. As a result, the gas is much hotter than in the thermo-coupled case, where the gas and dust temperatures are equal, reaching a few thousands K in the upper disc layers and making the inner rim higher. A physically motivated density drop at the inner radius ("soft-edge") results in rounded inner rims, which appear ring-like in near-infrared images. The...

  6. Inertial effects at moderate Reynolds number in thin-film rimming flows driven by surface shear

    Science.gov (United States)

    Kay, E. D.; Hibberd, S.; Power, H.

    2013-10-01

    In this paper, we study two-dimensional thin-film flow inside a stationary circular cylinder driven by an imposed surface shear stress. Modelling is motivated by a need to understand the cooling and film dynamics provided by oil films in an aero-engine bearing chamber characterised by conditions of very high surface shear and additional film mass flux from oil droplets entering the film through the surface. In typical high-speed operation, film inertial effects can provide a significant leading-order mechanism neglected in existing lubrication theory models. Inertia at leading-order is included within a depth-averaged formulation where wall friction is evaluated similar to hydraulic models. This allows key nonlinear inertial effects to be included while retaining the ability to analyse the problem in a mathematically tractable formulation and compare with other approaches. In constructing this model, a set of simplified mass and momentum equations are integrated through the depth of the film yielding a spatially one-dimensional depth-averaged formulation of the problem. An a priori assumed form of velocity profile is needed to complete the system. In a local Stokes flow analysis, a quadratic profile is the exact solution for the velocity field though it must be modified when inertial effects become important. Extension of the velocity profile to a cubic profile is selected enabling specification of a wall friction model to include the roughness of the cylinder wall. A modelling advantage of including the inertia term, relevant to the applications considered, is that a smooth progression in solution can be obtained between cases of low Reynolds number corresponding to lubrication theory, and high Reynolds number corresponding to uniform rimming-flow. Importantly, we also investigate the effect of inertia on some typical solutions from other studies and present a greater insight to existing and new film solutions which arise from including inertia effects.

  7. Distinct focal lesions of the femoral head: imaging features suggesting an atypical and minimal form of bone necrosis

    International Nuclear Information System (INIS)

    Heading AbstractObjective. To document the imaging findings observed in patients with an unusual pattern of abnormality of the femoral head, most likely representing osteonecrosis.Design and patients. The imaging findings in 11 patients (10 men, 1 woman; age range 32-55 years) with a distinct lesion of the femoral head were reviewed with particular attention to the morphologic appearance, location, and extent of the lesion(s) in the proximal femur.Results. The 16 lesions identified in these patients extended to the subchondral area. Articular collapse was not evident in any hip. Radiography and CT showed areas of mixed bone sclerosis and osteolysis surrounded by sclerotic margins. On MR imaging, the signal intensity characteristics of the osseous lesion(s) were most commonly similar to those of fluid. Histopathologic findings, available in two hips, were typical of osteonecrosis. There was evidence of correlation of the site of the lesion with the known general distribution and anastomoses of arteries supplying the femoral head.Conclusion. A distinct, focal lesion of the femoral head is believed to represent an atypical form of bone necrosis. Its restriction to a small portion of the femoral head may relate to localized vascular anatomy. Recognition of the quite characteristic imaging findings can prevent misdiagnosis and may have implications for the prediction of the natural course of the disease. (orig.)

  8. Multiple soft tissue aneurysmal cysts: An occurrence after resection of primary aneurysmal bone cyst of fibula

    Directory of Open Access Journals (Sweden)

    Karkuzhali P

    2007-01-01

    Full Text Available We report a case of multiple extraosseous aneurysmal cysts occurring in the muscle and subcutaneous plane of postero-lateral aspects of the upper right leg. They appeared about 15 months after resection of aneurysmal bone cyst of the upper end of the fibula. They varied in size from 2 cm to 5 cm. Radiologically they were well-defined lesions with central septate areas surrounded by a rim of calcification. Histologically they showed central cystic spaces separated by septa consisting of fibroblasts, osteoclast type of giant cells and reactive woven bone. Thus they showed histological similarity with aneurysmal bone cysts, but did not show any connection with the bone. Only very few examples of aneurysmal cysts of soft tissue had been described in the past one decade and they were reported in various locations including rare sites such as arterial wall and larynx. Recent cytogenetic analyses have shown abnormalities involving 17p11-13 and/or 16q22 in both osseous and extraosseous aneurysmal cysts indicating its probable neoplastic nature. Our case had unique features like multiplicity and occurrence after resection of primary aneurysmal bone cyst of the underlying bone.

  9. Bone scintigraphy and densitometry in symptomatic haemodialysis bone disease

    International Nuclear Information System (INIS)

    Bone scintigraphy and densitometry (iodine-125 photon absorptiometry) were performed in eight patients with symptomatic haemodialysis bone disease. The bone scintiscan showed either hot spots or hyperactivity as a feature of metabolic bone disease. The bone density (BMC/W) was reduced, but could not be distinguished from the degree of demineralisation found in asymptomatic patients on longterm haemodialysis. Therefore, bone density measurements require critical interpretation. Complementary bone scintigraphy should be used in symptomatic haemodialysis bone disease for assessing the extent of the disease. (orig.)

  10. Bone scintigraphy and densitometry in symptomatic haemodialysis bone disease

    Energy Technology Data Exchange (ETDEWEB)

    Alberts, C.; van der Schoot, J.B.; Busemann-Sokole, E.

    1981-11-01

    Bone scintigraphy and densitometry (iodine-125 photon absorptiometry) were performed in eight patients with symptomatic haemodialysis bone disease. The bone scintiscan showed either hot spots or hyperactivity as a feature of metabolic bone disease. The bone density (BMC/W) was reduced, but could not be distinguished from the degree of demineralisation found in asymptomatic patients on longterm haemodialysis. Therefore, bone density measurements require critical interpretation. Complementary bone scintigraphy should be used in symptomatic haemodialysis bone disease for assessing the extent of the disease.

  11. Bone marrow (stem cell) donation

    Science.gov (United States)

    ... fatty tissue inside your bones. Bone marrow contains stem cells, which are immature cells that become blood cells. ... marrow transplant . This is now often called a stem cell transplant. For this type of treatment, bone marrow ...

  12. Exercise for Your Bone Health

    Science.gov (United States)

    ... supported by your browser. Home Bone Basics Lifestyle Exercise for Your Bone Health Publication available in: PDF ( ... A Complete Osteoporosis Program For Your Information Why Exercise? Like muscle, bone is living tissue that responds ...

  13. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... or in bones. top of page How should I prepare? Most bone x-rays require no special ... to 10 minutes. top of page What will I experience during and after the procedure? A bone ...

  14. More Evidence of the Importance of Amorphous Silicates in CM Carbonaceous Chondrites: New Observations from a Fine-Grained Rim in the CM2 Chondrite, TIL 91722

    Science.gov (United States)

    Brearley, A. J.; Le Guillou, C.

    2015-07-01

    A fine-grained rim in TIL 91722 contains abundant amorphous silicate material containing nanophase sulfides. Phyllosilicates are rare. The amorphous material has a high ferric iron content indicative of oxidation coupled with hydration.

  15. The “Rügener Inklusionsmodell” (RIM – Effects of a school concept based on the Response to Intervention approach on the mathematics and reading achievement of German elementary school students

    Directory of Open Access Journals (Sweden)

    Stefan Voß

    2014-05-01

    Full Text Available Since the school year 2010/2011 on the Isle of Rügen every child starting school gets enrolled at the regular elementary school whether it has special needs or not. Framework for the structure and organization of these preventive and inclusive schools is the concept “Rügener Inklusionsmodell” (RIM which is an adaption of the US-american Response to Intervention approach (RTI. The RIM is the first large-scale implementation of a school concept in Germany which is based on RTI. This study analyses the effects of the RIM after two school years in comparison to the conventional school concept. The positive effects of RTI reported in US literature could not be replicated however findings do indicate that the RIM provides an appropriate inclusive school setting. Results for children with learning disabilities are not reliable at this point but will be presented later at the end of grade three.

  16. Study on Mass Discrimination Effect of Resonance Ionization Mass Spectrometry Using an Inductively Coupled Plasma as an Atomic Source (ICP-RIMS)

    International Nuclear Information System (INIS)

    We have proposed a novel concept of Resonance Ionization Mass Spectrometry using an Inductively Coupled Plasma as an Atomic Source (ICP-RIMS). Isotope ratio analysis using ICP-RIMS is expected to be a convenient and precise technique with high throughput. However, the mass discrimination effect caused from difference in kinetic energy of neutral atoms in ICP-RIMS is crucial for precise isotope analysis. We, therefore, investigated the atom kinetic energy distribution introduced into the laser ionization region. The mass-dependent kinetic energy was confirmed in the initial kinetic energy distributions. We preliminary estimated a mass discrimination effect caused by mass-dependent kinetic energy in ICP-RIMS for various detector sizes. We proposed that this effect can be suppressed by selecting the appropriate detector size and adopting the scanning mode of the deflecting voltage.

  17. Subperiosteal ganglion associated with Paget's disease of bone

    Energy Technology Data Exchange (ETDEWEB)

    Mansour, R.; Nanni, M.; Muthukumar, T.; Butt, S.H.; Cassar-Pullicino, V.N. [Robert Jones and Agnes Hunt Orthopaedic Hospital, Department of Radiology, Oswestry, Shropshire (United Kingdom)

    2005-07-01

    Tumoral lesions related to Paget's disease may be classified as malignant, benign or pseudotumoral. While sarcomatous degeneration is the most feared complication, awareness of benign and pseudotumoral lesions is essential for assisting in accurate histological interpretation of the biopsy sample, which may avoid unnecessary repeat biopsies. We present the first case of a juxta-articular subperiosteal ganglion associated with Paget's disease, with classic imaging characteristics, especially on CT examination. The well-defined soft tissue mass at the medial aspect of the obturator rim, adjacent to a small fracture in pagetic quadrilateral plate, showed an ossified rim and internal gas lucencies, these being the hallmarks of a juxta-articular subperiosteal ganglion. On MRI, the lesion was of intermediate signal intensity on T1-weighted sequences, increased signal intensity on T2-weighted sequences, with rim enhancement after gadolinium contrast injection and preservation of fatty marrow signal of the underlying pagetic bone. Identification of the entity avoided an unnecessary biopsy or surgical intervention. (orig.)

  18. Pseudoanaplastic tumors of bone

    International Nuclear Information System (INIS)

    To discuss the concept of pseudoanaplastic tumors of bone, which pathologically show hyperchromatism and marked pleomorphism with quite enlarged, pleomorphic nuclei, but with no to extremely rare, typical mitoses, and to propose guidelines for their diagnosis. From a database of 4,262 bone tumors covering from 1971 to 2001, 15 cases of pseudoanaplastic bone tumors (0.35% of total) were retrieved for clinical, radiographic and pathologic review. Postoperative follow-up after surgical treatment was at least 3 years and a maximum of 7 years. There were eight male and seven female patients. Their ages ranged from 10 to 64 years with average of 29.7 years. Pathologic diagnoses of pseudoanaplastic variants of benign bone tumors included: osteoblastoma (4 cases), giant cell tumor (4 cases), chondromyxoid fibroma (3 cases), fibrous dysplasia (2 cases), fibrous cortical defect (1 case) and aneurysmal bone cyst (1 case). Radiography of all cases showed features of a benign bone lesion. Six cases, one case each of osteoblastoma, fibrous dysplasia, aneurysmal bone cyst, chondromyxoid fibroma, giant cell tumor and osteoblastoma, were initially misdiagnosed as osteosarcoma. The remaining cases were referred for a second opinion to rule out sarcoma. Despite the presence of significant cytologic aberrations, none of our cases showed malignant behavior following simple curettage or removal of bony lesions. Our observation justifies the concept of pseudoanaplasia in some benign bone tumors as in benign soft tissue tumors, especially in their late evolutionary stage when bizarre cytologic alterations strongly mimic a sarcoma. (orig.)

  19. Pseudoanaplastic tumors of bone

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Won-Jong [Uijongbu St. Mary Hospital, The Catholic University of Korea, Department of Orthopaedic Surgery, Gyunggido, 480-821 (Korea); Mirra, Joseph M. [Orthopaedic Hospital, Orthopedic Oncology, Los Angeles, California (United States)

    2004-11-01

    To discuss the concept of pseudoanaplastic tumors of bone, which pathologically show hyperchromatism and marked pleomorphism with quite enlarged, pleomorphic nuclei, but with no to extremely rare, typical mitoses, and to propose guidelines for their diagnosis. From a database of 4,262 bone tumors covering from 1971 to 2001, 15 cases of pseudoanaplastic bone tumors (0.35% of total) were retrieved for clinical, radiographic and pathologic review. Postoperative follow-up after surgical treatment was at least 3 years and a maximum of 7 years. There were eight male and seven female patients. Their ages ranged from 10 to 64 years with average of 29.7 years. Pathologic diagnoses of pseudoanaplastic variants of benign bone tumors included: osteoblastoma (4 cases), giant cell tumor (4 cases), chondromyxoid fibroma (3 cases), fibrous dysplasia (2 cases), fibrous cortical defect (1 case) and aneurysmal bone cyst (1 case). Radiography of all cases showed features of a benign bone lesion. Six cases, one case each of osteoblastoma, fibrous dysplasia, aneurysmal bone cyst, chondromyxoid fibroma, giant cell tumor and osteoblastoma, were initially misdiagnosed as osteosarcoma. The remaining cases were referred for a second opinion to rule out sarcoma. Despite the presence of significant cytologic aberrations, none of our cases showed malignant behavior following simple curettage or removal of bony lesions. Our observation justifies the concept of pseudoanaplasia in some benign bone tumors as in benign soft tissue tumors, especially in their late evolutionary stage when bizarre cytologic alterations strongly mimic a sarcoma. (orig.)

  20. Biodegradable synthetic bone composites

    Science.gov (United States)

    Liu, Gao; Zhao, Dacheng; Saiz, Eduardo; Tomsia, Antoni P.

    2013-01-01

    The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

  1. Gentamicin in bone cement

    OpenAIRE

    Chang, Y; Tai, C-L.; Hsieh, P-H.; Ueng, S. W. N.

    2013-01-01

    Objectives The objective of this study is to determine an optimal antibiotic-loaded bone cement (ALBC) for infection prophylaxis in total joint arthroplasty (TJA). Methods We evaluated the antibacterial effects of polymethylmethacrylate (PMMA) bone cements loaded with vancomycin, teicoplanin, ceftazidime, imipenem, piperacillin, gentamicin, and tobramycin against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staph. aureus (MRSA), coagulase-negative staphylococci (C...

  2. Bone mineral density test

    Science.gov (United States)

    ... Bone density test; Bone densitometry; DEXA scan; DXA; Dual-energy x-ray absorptiometry; p-DEXA; Osteoporosis-BMD ... The most common and accurate way uses a dual-energy x-ray absorptiometry (DEXA) scan. DEXA uses low- ...

  3. Ear and temporal bone

    International Nuclear Information System (INIS)

    Radioanatomy of ear and temporal bone is described. Problems of X-ray examination of the diseases of ear and mastoid process (disturbance of ear development, inflammatory diseases, otosclerosis, tumors) are considered. Roentgenoframs of temporal bone of healthy people and that in some diseases are presented and aanalyzed

  4. Bone Mineral Measurements.

    Science.gov (United States)

    Doroudinia, Abtin; Colletti, Patrick M

    2015-08-01

    The accurate measurement of bone mineral density using noninvasive methods can be of value in the detection and evaluation of primary and secondary causes of decreased bone mass. This includes primary osteoporosis and secondary disorders, such as hyperparathyroidism, osteomalacia, multiple myeloma, diffuse metastases, and glucocorticoid therapy or intrinsic excess.By far, the largest patient population is that encompassed by primary osteoporosis with increased susceptibility to fractures in the absence of other recognizable causes of bone loss.Primary osteoporosis is a common clinical disorder and a major public health problem because of the significant number of related bone fractures occurring annually. Because the risk of vertebral and femoral neck fractures rises dramatically as bone mineral density falls, fracture risk in individual patients may be estimated. Furthermore, in estrogen-deficient women, bone mineral density values may be used to make rational decisions about hormone replacement therapy, or other bone mineral therapies, and as follow-up in assessing the success of such treatment.In this article, we discuss different methods of bone densitometry and will focus on dual-energy x-ray absorptiometry (DXA) with discussing the factors which should be considered for interpretation of DXA scan. PMID:26147459

  5. Evaluation of sequential FDG-PET/CT for monitoring bone metastasis of breast cancer during therapy. Correlation between morphological and metabolic changes with tumor markers

    International Nuclear Information System (INIS)

    The purpose of this study was to clarify the significance of positron emission tomography (PET) and computed tomography (CT) findings for evaluating the bone metastasis of breast cancer during therapy. Forty-seven patients with bone metastases from breast cancer who underwent sequential 18F-flourodeoxyglucose (FDG)-PET/CT studies during therapy were enrolled. A total of 771 lesions were identified. The changes in the PET and CT findings were compared with the tumor marker levels in each patient by calculating the weighted kappa value. The correlation between the PET and CT findings was examined for each lesion by an adjusted Chi-square test. The change in the tumor marker levels was substantially correlated with the PET findings and moderately correlated with the CT findings (weighted kappa=0.780 and 0.585 for quadratic weighting, respectively). An increase in FDG uptake was correlated with lytic changes on the CT images (62/65, 95.4%, p<0.05). Sclerotic changes suggested improvement, but sclerosis and progression occurred at the same time in some lesions. Changes of FDG uptake are useful for evaluating individual bone metastases in cases of breast cancer during therapy. Lytic change on CT images suggests progression of bone metastasis. The lysis-progression/sclerosis-improvement pattern was observed in the majority of subjects, but a sclerosis-progression pattern was also observed. The hybrid pattern of increase of FDG uptake on PET/lytic change on CT is most accurate to show progression of bone metastases. Assessments of these processes during therapy are necessary for the precise evaluation of bone metastases. (author)

  6. A preclinical trial of sialic acid metabolites on distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy, a sugar-deficient myopathy: a review

    OpenAIRE

    Malicdan, May Christine V.; Noguchi, Satoru; NISHINO, Ichizo

    2010-01-01

    Distal myopathy with rimmed vacuoles (DMRV), also called hereditary inclusion body myopathy (hIBM), is a moderately progressive hereditary muscle disorder affecting young adults. DMRV/hIBM is characterized clinically by muscle atrophy and weakness initially involving the distal muscles, and pathologically by the presence of small angular fibers, formation of rimmed vacuoles and deposition of various proteins in the muscle fibers. This disease is known to be caused by mutations in the UDP-N-ac...

  7. The petrous bone

    DEFF Research Database (Denmark)

    Jørkov, Marie Louise Schjellerup; Heinemeier, Jan; Lynnerup, Niels

    2009-01-01

    Intraskeletal variation in the composition of carbon (delta(13)C) and nitrogen (delta(15)N) stable isotopes measured in collagen is tested from various human bones and dentine. Samples were taken from the femur, rib, and petrous part of the temporal bone from well-preserved skeletons of both adults...... (n = 34) and subadults (n = 24). Additional samples of dentine from the root of 1st molars were taken from 16 individuals. The skeletal material is from a medieval cemetery (AD 1200-1573) in Holbaek, Denmark. Our results indicate that the petrous bone has an isotopic signal that differs significantly...... this study it is believed the petrous bone may be a new useful bone element and a supplement or a proxy for teeth in the analysis of early dietary patterns as it may reflect diet in fetal stages and early years of life....

  8. Timescales and mechanisms of REE and Hf uptake in fossil bones

    Science.gov (United States)

    Herwartz, Daniel; Tütken, Thomas; Münker, Carsten; Jochum, Klaus Peter; Stoll, Brigitte; Sander, P. Martin

    2011-01-01

    Rare earth element (REE) patterns of fossil bones and teeth are widely used as proxies for provenance, taphonomy, and palaeoenvironment. In order to investigate if fossil bones behave as closed systems over geologic time, REE profiles were analysed by LA-ICPMS along cross sections of 54 bones from various well-characterised and well-dated settings. These include terrestrial and marine diagenetic environments, covering Early Triassic to Holocene ages. In general, all fossil bones exhibit the highest REE concentrations at the outer rim, gradually decreasing by up to four orders of magnitude toward the inner bone cortex. Intra-bone REE concentration gradients decrease significantly from Quaternary via Tertiary to Mesozoic specimens, suggesting long term REE uptake and open system behaviour of fossil bone. This view is further corroborated by 176Lu- 176Hf dating of selected samples, all yielding significantly younger ages than the known chronostratigraphic ages. Hence, there is clear evidence for long term open system behaviour of fossil bones with respect to REE, which is in marked contrast to currently accepted models suggesting that REE uptake is only early diagenetic. Although unexpected, statistically significant four to seven point isochrons are observed for four fossil dinosaur bone samples and one Upper Triassic Mastodonsaurus tooth with MSWDs ranging from 0.083 to 4.5. Notably, mobility of Lu alone cannot account for the observed age patterns. Assuming constant Lu uptake rates over time, the radiometric ages should only be as low as half of the chronostratigraphic age. However, a six-point isochron defined by subsamples of a single Upper Triassic Mastodonsaurus tooth yields an age of 65.2 ± 1.1 Ma (MSWD = 0.68), much younger than half of the stratigraphic age (ca. 234 Ma). Hence, Hf must also undergo late diagenetic exchange. Likely mechanisms to account for the presence of statistically meaningful isochrons as well as for the late diagenetic exchange of both REE and Hf are diffusion, adsorption, and dissolution-reprecipitation processes.

  9. Calcium Intake and Bone health

    Medline Plus

    Full Text Available ... not improve bone health, according to two new studies. Researchers reviewed randomized controlled trials and observational studies that looked at whether extra calcium improved bone ...

  10. Temporal bone CT findings of tuberculous otitis media : comparison with chronic otitis media

    International Nuclear Information System (INIS)

    To compare the differential findings of tuberculous otitis media(TOM) with those of chronic sup purative otitis media with or without cholesteatoma, as seen on high resolution temporal bone CT. We retrospectively reviewed 14 cases of TOM, 30 cases of chronic suppurative otitis media(CSOM), and 30 cases of chronic otitis media with cholesteatoma(Chole). All had been pathologically confirmed. We evaluated the preservation of mastoid cells without sclerotic change, the location and extension of soft tissue to the external auditary canal, and erosion of ossicles, the tegmen tympani, scutum, bony labyrinth, facial nerve canal and sigmoid sinus, and the presence of intracranial complications. Soft tissue in the mastoid antrum was seen in all cases of TOM(100%), 29 cases of CSOM(96.7%), and 26 cases of Chole(86.7%). In contrast, the soft tissue in the entire middle ear cavity was noted in 13 cases of TOM(92.8%), 7 cases of CSOM(23.3%), and 12 cases of Chole(40%). Soft tissue extended to the superior aspect of the external auditory canal in 4 cases of TOM (28.6%) and 5 cases of Chole (16.7%). Mastoid air cells were seen in 9 cases of TOM (64.3%), 4 cases of CSOM (13.3%), and 3 cases of Chole(10%). Ossicular erosion was noted in 6 cases of TOM (42.9%), 12 cases of CSOM (40%), and 26 cases of Chole(86.7%), while in one case of TOM (7.1%), 5 cases of CSOM (16.7%), and 15 cases of Chole(50%) there was erosion of the scutum. In one case of TOM, follow-up CT study after 9 months of antituberculous medication without surgery revealed complete clearing of previously noted soft tissue in the middle ear cavity. Specific CT findings of TOM were not seen, but if there were findings of soft tissue in the entire middle ear cavity, soft tissue extension to the external auditory canal, preservation of mastoid air cells without sclerotic change, and intact scutum, TOM may be differentiated from other chronic otitis media

  11. Bone cysts and cystic lesions of bone

    International Nuclear Information System (INIS)

    Cystic and cyst-like lesions of bone are very common. They can be of primary origin or secondarily caused by several diseases. For exact diagnosis or at least narrow differential diagnosis the assessment of radiological findings is important. However, patient data, clinical symptoms, laboratory parameters, and site of the lesion have to be included for a reasonable final diagnosis or differential diagnosis. (orig.)

  12. TRIGGERED STAR FORMATION IN A BRIGHT-RIMMED CLOUD (BRC 5) OF IC 1805

    Energy Technology Data Exchange (ETDEWEB)

    Fukuda, Naoya [Faculty of Biosphere-Geosphere Science, Okayama University of Science, 1-1 Ridai-chou, Okayama 700-0005 (Japan); Miao, Jingqi [Centre for Astrophysics and Planetary Science, School of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NR (United Kingdom); Sugitani, Koji [Graduate School of Natural Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-8501 (Japan); Kawahara, Kentaro [Faculty of Informatics, Okayama University of Science, 1-1 Ridai-chou, Okayama 700-0005 (Japan); Watanabe, Makoto [Department of Cosmosciences, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0810 (Japan); Nakano, Makoto [Faculty of Education and Welfare Science, Oita University, Oita 870-1192 (Japan); Pickles, Andrew J., E-mail: fukudany@big.ous.ac.jp [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Goleta, CA 93117 (United States)

    2013-08-20

    We report recent optical, near-infrared (NIR), and millimeter observations which have revealed some new features of the bright-rimmed cloud BRC 5 associated with W4. With slitless spectroscopy, we detected 17 H{alpha} emission stars around the cloud; 4 are near the surface of the cloud, and 1 is toward IRAS 02252+6120. NIR photometry shows that the central H{alpha} emission star, together with one bright infrared source, has large NIR excesses and Class I spectral energy distributions. These two Class I objects are associated with the 2.9 mm continuum peaks and with a bipolar outflow, and are in between two separate, elongated C{sup 18}O(J = 1-0) cores. The C{sup 18}O cores and the two Class I sources are aligned along a line at position angle {approx}240 Degree-Sign , somewhat less than perpendicular to the direction of UV radiation from the OB stars. Most of the detected H{alpha} emission stars, all T Tauri candidates, are located within {approx}3' of the cloud on the exciting star side. An estimate of the age of the stars based on a color-magnitude diagram suggests that these T Tauri candidates have ages of {approx}1 Myr or less, but are more evolved objects than the central young stellar objects. This age sequence suggests sequential star formation within the BRC 5 cloud. The {sup 13}CO(J = 1-0) emission shows three elongated structures, which indicates the asymmetric structure toward the UV incident axis. We present our exploratory simulation results by using a smoothed particle hydrodynamic code that suggests that the asymmetrical BRC 5 structure could possibly result from the evolution of a preexisting prolate molecular cloud subject to radiation-driven implosion (RDI). Our best-fit prolate cloud has an initial mass of {approx}400 M{sub Sun }, an axial ratio of {approx}1.7, and a semi-major axis of {approx}1.6 pc, pointing away from the ionization flux by an angle of 15 Degree-Sign . The simulated cloud structure not only closely matches the observed asymmetric morphological structure of BRC 5, but also reveals the possibility of the development of two major cores at the head of BRC 5. For the first time, the possibility of forming two stars by an RDI mechanism in a BRC is investigated.

  13. TRIGGERED STAR FORMATION IN A BRIGHT-RIMMED CLOUD (BRC 5) OF IC 1805

    International Nuclear Information System (INIS)

    We report recent optical, near-infrared (NIR), and millimeter observations which have revealed some new features of the bright-rimmed cloud BRC 5 associated with W4. With slitless spectroscopy, we detected 17 H? emission stars around the cloud; 4 are near the surface of the cloud, and 1 is toward IRAS 02252+6120. NIR photometry shows that the central H? emission star, together with one bright infrared source, has large NIR excesses and Class I spectral energy distributions. These two Class I objects are associated with the 2.9 mm continuum peaks and with a bipolar outflow, and are in between two separate, elongated C18O(J = 1-0) cores. The C18O cores and the two Class I sources are aligned along a line at position angle ?240°, somewhat less than perpendicular to the direction of UV radiation from the OB stars. Most of the detected H? emission stars, all T Tauri candidates, are located within ?3' of the cloud on the exciting star side. An estimate of the age of the stars based on a color-magnitude diagram suggests that these T Tauri candidates have ages of ?1 Myr or less, but are more evolved objects than the central young stellar objects. This age sequence suggests sequential star formation within the BRC 5 cloud. The 13CO(J = 1-0) emission shows three elongated structures, which indicates the asymmetric structure toward the UV incident axis. We present our exploratory simulation results by using a smoothed particle hydrodynamic code that suggests that the asymmetrical BRC 5 structure could possibly result from the evolution of a preexisting prolate molecular cloud subject to radiation-driven implosion (RDI). Our best-fit prolate cloud has an initial mass of ?400 M?, an axial ratio of ?1.7, and a semi-major axis of ?1.6 pc, pointing away from the ionization flux by an angle of 15°. The simulated cloud structure not only closely matches the observed asymmetric morphological structure of BRC 5, but also reveals the possibility of the development of two major cores at the head of BRC 5. For the first time, the possibility of forming two stars by an RDI mechanism in a BRC is investigated

  14. Usefulness of {sup 18}F fluoride PET/CT in breast cancer patients with osteosclerotic bone metastases

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Seok Ho; Kim, Ku Sang; Kang, Seok Yun; Song, Hee Sung; Jo, Kyung Sook; Lee, Su Jin; Yoon, Joon Kee; An, Young Sil [Ajou Univ., Suwon (Korea, Republic of); Choi, Bong Hoi [Gyeongsang National Univ. Hospital, Jinju (Korea, Republic of)

    2012-03-15

    Bone metastasis is an important factor for the treatment and prognosis of breast cancer patients. Whole body bone scintigraphy (WBBS) can evaluate skeletal metastases, and {sup 18}F FDG PET/CT seems to exhibit high specificity and accuracy in detecting bone metastases. However, there is a limitation of {sup 18}F FDG PET in assessing sclerotic bone metastases because some lesions may be undetectable. Recent studies showed that {sup 18}F fluoride PET/CT is more sensitive than WBBS in detecting bone metastases. This study aims to evaluate the usefulness of {sup 18}F fluoride PET/CT by comparing it with WBBS and {sup 18}F FDG PET/CT in breast cancer patients with osteosclerotic skeletal metastases. Nine breast cancer patients with suspected bone metastases (9 females; mean age {+-} SD, 55.6{+-}10.0 years) underwent {sup 99m}Tc MDP WBBS, {sup 18}F FDG PET/CT and {sup 18}F fluoride PET/CT. Lesion based analysis of five regions of the skeletons(skull, vertebral column, thoracic cage, pelvic bones and long bones of extremities) and patient based analysis were performed. {sup 18}F fluoride PET/CT, {sup 18}F FDG PET/CT and WBBS detected 49, 20 and 25 true metastases, respectively. Sensitivity, specificity, positive predictive value and negative predictive value of {sup 18}F fluoride PET/CT were 94.2%, 46.3%, 57.7% and 91.2%, respectively. Most true metastatic lesions of {sup 18}F fluoride PET/CT had osteosclerotic change (45/49, 91.8%), and only four lesions showed osteolytic change. Most lesions on {sup 18}F FDG PET/CT also demonstrated osteosclerotic change (17/20, 85.0%) with three osteolytic lesions. All true metastatic lesions detected on WBBS and {sup 18}F FDG PET/CT were identified on {sup 18}F fluoride PET/CT. {sup 18}F FDG PET/CT in detecting osteosclerotic metastatic lesions. {sup 18}F fluoride PET/CT might be useful in evaluating osteosclerotic metastases in breast cancer patients.

  15. Buyer's guide to telescopes at the best sites: Dome A, L2, and Shackleton Rim

    Science.gov (United States)

    Angel, J. Roger P.

    2004-10-01

    Future optical/infrared telescopes will need to be much larger than today"s, if they are to address such key challenges as direct observations of Earth-like exoplanets and of the first stars formed after the big bang. In this paper I consider the most promising of the new sites, both on the ground and in space, and telescope concepts to take advantage of their complementary scientific potential. Ground based telescopes with adaptive optics will be capable of diffraction limited imaging, down to a short wavelength limit set by the amplitude and speed of the atmospheric turbulence. The best conditions are on the high Antarctic plateau, where recent measurements at Dome C show turbulence typically half the amplitude of the best temperate sites, with temporal evolution at half the speed1. Thus uniquely in Antarctica, diffraction limited imaging at optical wavelengths should be practical. Conditions there are also best for infrared astronomy, given the combination of minimal aberration and winter temperatures averaging as low as 200K at Dome A (the highest point). In space, well away from the warm Earth, conditions are even better, with 24 hour/day observing free from all atmospheric aberration, and the potential for passive cooling to 50K or less by use of a sunshield. L2 and the Moon's south pole are such optimal space locations. A telescope at L2 requires only a little fuel to stay on orbit, and can be accurately pointed despite solar torques by well established active methods based on star trackers, gyros and reaction wheels. By contrast, the Moon provides a completely stable platform where a telescope with no moving parts can remain pointed indefinitely along the spin axis, or a telescope on a hexapod mount can be oriented and tracked by reaction to the turning lunar surface. Solar shielding on the Moon requires a polar location such as the high rim of the Shackleton crater, adjacent to the south pole, where there is also nearly continuous solar power. Long term operation large telescopes in space should be possible at affordable cost if we adopt the strategy used on the ground, where the same telescope OTA and mount is maintained for decades while instruments are periodically upgraded. HST has already shown the power of this modus operandi in space. It makes sense because the optical image quality of any telescope cannot be improved once the diffraction limit is reached, while instruments need to be renewed to keep pace with scientific and technical developments. Thus if future space exploration results in long-term robotic or human infrastructure on the Moon, the Shackleton rim would be favored as an observatory site, especially for ultra-deep optical/infrared surveys. If, on the other hand, exploration is centered a new station in free space, out of the Earth's gravitational potential well, observatories at L2 would be more easily supported. When contrasting the performance of ground and space telescope options, an important trade is larger aperture on Earth versus lower background in space The thermal zodiacal background of space is typically 105 times lower than even the Antarctic background, and the optical scattered starlight background in space is much less, but because of the strong dependence of sensitivity on diameter a 100 m telescope at Dome A or Dome C would have sensitivity and power to study Earth-like planets comparable to that of NASA's proposed TPF coronagraphic and interferometric missions combined. For ultradeep field studies in the infrared, integration time is also important, thus a 20 m fixed telescope on the lunar south pole surveying just the south ecliptic pole region would have nearly 100 times the sensitivity of the JWST at L2. Neither Dome A nor the Moon"s south pole has yet been explored, even robotically. If large telescopes are ever to be built at these optimum sites, smaller precursors must be built first to develop the required technology and to gain experience. On the Moon, a start which would yield already interesting science could be made with a 3-m class, fixed, roboticall

  16. Bone scintigraphy for horses

    International Nuclear Information System (INIS)

    Scintigraphy (bone scan) is being used approximately since 1980 in the horse under general anaesthesia. With the construction of custom-made overhead gantries for gamma-cameras scintigraphy found widespread entry in big equine referral hospitals for bone-scanning of the standing horse. Indications for the use of a bone scan in the horse are inflammatory alterations in the locomotor apparatus. It is primarily used for diagnosis of lameness of unknown origin, suspect of stress fracture or hairline fracture and for horses with bad riding comfort with suspected painful lesions in the spine. (orig.)

  17. Paget Disease of Bone.

    Science.gov (United States)

    Al-Rashid, Mamun; Ramkumar, Dipak B; Raskin, Kevin; Schwab, Joseph; Hornicek, Francis J; Lozano-Calderón, Santiago A

    2015-10-01

    The current understanding of Paget disease of bone (PDB) has vastly changed since Paget described the first case in 1877. Medical management of this condition remains the mainstay of treatment. Surgical intervention is usually only used in fractures through pagetic bone, need for realignment to correct deformity in major long bones, prophylactic treatment of impending fractures, joint arthroplasty in severe arthritis, or spinal decompression in cases of bony compression of neural elements. Advances in surgical technique have allowed early return to function and mobilization. Despite medical and surgical intervention, a small subset of patients with PDB develops Paget sarcoma. PMID:26410646

  18. Hidden bone erosions

    Directory of Open Access Journals (Sweden)

    F. Salaffi

    2011-09-01

    Full Text Available The aim of this pictorial essay was to demonstrate the diagnostic efficacy of high-resolution sonography in detecting bone erosions in a patient with rheumatoid arthritis. Standard X-Ray of the feet did not reveal clearly evident erosions. Ultrasonography was able to detect the presence of bone erosions of the metatarsal heads of both the first toes and of the V toe of the left foot. Because the appearance of bone erosions on radiographs of a patient with a recent onset arthritis indicates a poor prognosis, the possibility of demonstrating small hidden erosions at the level of the early targets of the disease is of relevant practical value.

  19. Periodontal bone lesions

    International Nuclear Information System (INIS)

    In the course of life the periodontum is subject to changes which may be physiological or pathological. Intraoral radiographs give insight into the hard structures of the dentomaxillar region and provides information on lesions in the bone of the periodontum in that they show radiopacities and radiolucencies caused by such lesions. In this thesis the relation is investigated between the true shape and dimensions of periodontal bone lesions and their radiographic images. A method is developed and tested of making standardized and reproducible radiographs suitable for longitudinal studies of periodontal lesions. Also the possibility is demonstrated of an objective and reproducible interpretation of radiographic characteristics of periodontal bone lesions. (Auth.)

  20. Rim Thickness Factor to Evaluate Fracture Resistance of Spur Gears Factor por espesor de llanta para evaluar resistencia a la fractura en ruedas dentadas

    Directory of Open Access Journals (Sweden)

    Gonzalo González Rey

    2011-06-01

    Full Text Available In thin rimmed gears running with sufficient bending stress resistance at the tooth-root, fatigue cracks with propagation through the rims, rather than at the tooth fillet, has been observed. Both the ISO and AGMA standards introduce stress-modifying factors (denominated rim thickness factors YB and KB for the bending stress calculation where the rim thickness is not sufficient to provide full support of the tooth root. However, some new experiences and tests of gears have evidenced that the effects of rim thickness on fracture resistance in spur gear are not completely considered with the ISO and AGMA factors for rim thickness. In this paper, some studies published about the effects of rim thickness on spur gear bending stress are reviewed. Moreover, the influence in the rim thickness factor of both rim backup ratio and web thickness ration is confirmed based on statistical analysis and a better formula for calculation of rim thickness factor is proposed.En engranajes de ruedas dentadas con llantas de pequeño espesor y con suficiente resistencia a los esfuerzos en la base de los dientes, ha sido observado el surgimiento de grietas en dirección transversal a la llanta con rotura por fractura de la rueda dentada. En las Normas ISO y AGMA se introducen factores modificadores de los esfuerzos (YB y KB para ruedas dentadas con llantas de pequeño espesor para valorar el esfuerzo en la base de los dientes de engranajes. Experiencias y ensayos de ruedas dentadas han puesto en evidencia que el efecto de fractura de las llantas no está totalmente considerado con los actuales factores de espesor de llanta presentes en las normas referidas. En el presente trabajo, son mostrados resultados derivados de un análisis de la interrelación entre el factor por adelgazamiento de llanta, la relación de espesor con referencia a la llanta y de los nervios del soporte en ruedas dentadas cilíndricas, que permitieron obtener una fórmula de mayor alcance para valorar el efecto del espesor de la llanta y el espesor de los nervios en la resistencia a la fractura de las ruedas dentadas.