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Sample records for sclerotic bone rim

  1. Sclerotic bone lesions at abdominal magnetic resonance imaging in children with tuberous sclerosis complex

    Boronat, Susana [Massachusetts General Hospital, Department of Neurology, Boston, MA (United States); Universitat Autonoma de Barcelona, Department of Pediatric Neurology, Vall d' Hebron Hospital, Barcelona (Spain); Barber, Ignasi [Universitat Autonoma de Barcelona, Department of Pediatric Radiology, Vall d' Hebron Hospital, Barcelona (Spain); Pargaonkar, Vivek [Massachusetts General Hospital, Department of Radiology, Boston, MA (United States); Chang, Joshua; Thiele, Elizabeth A. [Massachusetts General Hospital, Department of Neurology, Boston, MA (United States)

    2016-05-15

    Sclerotic bone lesions are often seen on chest CT in adults with tuberous sclerosis complex. To characterize bone lesions at abdominal MRI in children with tuberous sclerosis complex. This retrospective review included 70 children with tuberous sclerosis complex who had undergone abdominal MRI for renal imaging. An additional longitudinal study was performed in 50 children who had had two or more MRI scans. Abdominal CT (eight children) and radiographs (three children) were reviewed and compared with MRI. A total of 173 sclerotic bone lesions were detected in 51/70 children (73%; 95% confidence interval: 0.61-0.82) chiefly affecting vertebral pedicles. New lesions appeared in 20 children and growth of previous sclerotic bone lesions was documented in 14 children. Sclerotic bone lesions were more frequent in girls and in children with more extensive renal involvement. Sclerotic bone lesions are commonly detected by abdominal MRI in children with tuberous sclerosis complex. They usually affect posterior vertebral elements and their number and size increase with age. As current recommendations for tuberous sclerosis complex surveillance include renal MR performed in childhood, recognition of these lesions is useful. (orig.)

  2. Non-sclerotic bone involvement in Erdheim-Chester: PET/CT and MRI findings in a 15-year-old boy.

    White, Theresa V; Silvester, Nicholas C; Otero, Hansel J

    2016-08-01

    Erdheim-Chester disease is a rare form of non-Langerhans cell histiocytosis with multi-organ infiltration that occurs mainly in adults. Pediatric cases are extremely rare. Here we report a case of multisystemic Erdheim-Chester disease in a 15-year-old boy with central nervous system involvement and skeletal findings. Positron emission tomography (PET) and MRI were used to demonstrate characteristic bilateral, symmetrical medullary involvement of the metadiaphyses of long bones in the absence of the classic sclerotic radiographic appearance. This illustrates the potential for earlier diagnosis and visualization of therapeutic response in children. PMID:27028532

  3. Bone changes in tuberous sclerosis mimicking metastases

    Pui, M.H.; Kong Hwai Loong; Choo Hui Fen [National University Hospital (Singapore). Depts. of Diagnostic Radiology and Oncology

    1996-02-01

    Sclerotic and lytic bone changes of tuberous sclerosis (TS) can mimic bone metastases. A case is reported of a patient with concomitant sclerotic bone metastases from bronchogenic carcinoma and TS bone changes, diagnosed by bone scintigraphy and magnetic resonance imaging. The increased bone uptake and abnormal magnetic resonance signal allowed distinction of TS bone lesions from bone metastases. 6 refs., 4 figs.

  4. Bone changes in tuberous sclerosis mimicking metastases

    Sclerotic and lytic bone changes of tuberous sclerosis (TS) can mimic bone metastases. A case is reported of a patient with concomitant sclerotic bone metastases from bronchogenic carcinoma and TS bone changes, diagnosed by bone scintigraphy and magnetic resonance imaging. The increased bone uptake and abnormal magnetic resonance signal allowed distinction of TS bone lesions from bone metastases. 6 refs., 4 figs

  5. Sclerotic multiple myeloma with an unusual sunburst periosteal reaction occurring in the sternum.

    Li, Yuqing; Wu, Wenjuan; Zhang, Zekun; Ding, Yang; Latif, Mahrukh

    2015-05-01

    Multiple myeloma is a disseminated neoplastic monoclonal gammopathy that usually affects the skull, clavicle, rib, pelvis, spinal column, and proximal portions of the humerus and femur. The initial manifestation of multiple myeloma in the sternum is rare. The classic radiological presentations of multiple myeloma are multiple "punched-out" areas of bone destruction, expansile lytic lesions, and generalized osteoporosis. Primary sclerotic presentation is rare and occurs in only 3 % of cases. A sclerotic multiple myeloma with a sunburst periosteal reaction occurring in the sternum has not been reported in the English literature. We report a case of sclerotic multiple myeloma of a 49-year-old woman. In the sternum, the lesion displayed extensive sclerosis mixed with mottled lytic areas with a sunburst periosteal reaction occurring in the periphery, which radiologically mimicked an osteosarcoma. Multiple focal areas of sclerosis were also found in the right clavicle, pelvis, multiple ribs, and vertebrae. PMID:25351419

  6. Imaging diagnosis of the juxta-articular bone cyst

    Objective: To investigate the imaging features of the juxta-articular bone cyst(intra- osseous ganglia). Methods: The imaging findings of 54 cases histopathologically confirmed were studied retrospectively. X-ray, CT, and MRI were performed in 46 eases, 30 cases, and 14 cases, respectively. Results: Of the 54 cases, 27 arised from the ankle (including multiple lesions), 16 from the knee joint, 7 from the hip joint, 1 from the proximate end of the humerus, ulna, trapezium bone, the first phalange in each, and 1 from the talus and the distal end of the tibia. There were 43 cases (44 lesions) in the ankle and knee joints, with 29 (65.9%) lesions located in the medial articular surface. Fifty-four cases had thinning sclerotic rim, showing a unilocular round osteolytic appearance in 44 cases and a multiloculated-cystic appearance with septa in 10 cases. Discontinuous articular surface were seen in 15 cases, reticular surface collapse in 1, gas density in 3 and fluid-fluid plane in 1. (1) On x-ray films, 46 cases (47 lesions) with well-defined sclerotic rim revealed round, arch or irregular lyric areas at the adjacent articular surface. The fissures were found at the adjacent articular surface in 6 lesions. No joint spaces were abnormal. (2)On CT, 30 cases with sclerotic rim showed round in 19 lesions, arch in 3, and irregular in 8. The fissures were seen at the adjacent articular surface in 14 lesions. The density showed homogeneous in 27 lesions, and gas existed in 3. (3) Fourteen cases (15 lesions)showed hypointense to isointense signal on MR T1WI and hyperintense signal on T2WI. Fluid-fluid plane was found in 1 case. The fissures were observed at the adjacent articular surface in 8 lesions. 7 cases showed swelling soft tissue. Conclusion: The characteristic locations combined with the typical imaging features may suggest the diagnosis of jaxta-articular bone cyst. (authors)

  7. The effects of hydroxyapatite coating and bone allograft on fixation of loaded experimental primary and revision implants

    Søballe, Kjeld; Mouzin, Olivier R G; Kidder, Louis A;

    2003-01-01

    We used our established experimental model of revision joint replacement to examine the roles of hydroxyapatite coating and bone graft in improving the fixation of revision implants. The revision protocol uses the Søballe micromotion device in a preliminary 8-week period of implant instability for...... the presence of particulate polyethylene. During this procedure, a sclerotic endosteal bone rim forms, and a dense fibrous membrane is engendered, having macrophages with ingested polyethylene and high levels of inflammatory cytokines. At the time of revision after 8 weeks, the cavity is revised with...

  8. The sclerotic pedicle - how many causes are there?

    The sclerotic pedicle is a commonly encountered roentgen sign that may be associated with numerous conditions, both benign and malignant. The following paper discusses the common as well as the unusual causes of this interesting phenomenon and demonstrates the radiographic presentations of the various etiologies. (orig.)

  9. Ultraviolet A phototherapy for sclerotic skin diseases: a systematic review.

    Kroft, E.B.M.; Berkhof, N.J.; Kerkhof, P.C.M. van de; Gerritsen, R.M.; Jong, E.M.G.J. de

    2008-01-01

    BACKGROUND: Ultraviolet (UV) A-1 phototherapy is now available for a variety of skin diseases. Increasingly since 1995, there have been investigations of the efficacy of UVA-1 (340-400 nm) therapy for sclerotic skin diseases. Most studies undertaken treated patients who had localized scleroderma, bu

  10. The physiologic sclerotic dentin: A literature-based hypothesis.

    Kabartai, F; Hoffmann, T; Hannig, C

    2015-12-01

    Despite the many hypotheses trying to explain how the physiologic sclerotic dentin is formed, there has been so far no convincing explanation for all of its observations. In this review, we tried to make a hypothesis based on the facts published to date. We found that the apoptosis of odontoblasts, which takes place after the formation of the apical constriction, may be the key-factor for the development of physiologic sclerotic dentin, because the resulting apoptotic bodies cannot be eliminated through phagocytosis and become trapped within the dentinal tubules due to the continuous formation of secondary dentin. The apoptotic bodies suffer later from a secondary or apoptotic necrosis leading to the release of the internal contents of pyrophosphate and hydrogen phosphate. Pyrophosphate can dehydrate the dentin and hydrogen phosphate can demineralize it, leading to the release of Ca(2+) ions which then contribute to the intratubular mineralization. PMID:26404871

  11. [Chondromyxoid fibroma of bone: a rare benign bone tumor in children].

    Rouas, L; Malihy, A; Cherradi, N; Lamalmi, N; Alhamany, Z

    2004-12-01

    Chondromyxoid fibroma is a rare benign tumor that is typically found in the metaphyseal ends of long tubular bones, such as the tibia. The radiographic appearances are those of a single, lytic lesion with lobulated margins, septations, cortical expansion and a sclerotic rim. The classic histological feature of a chondromyxoid fibroma is stellate or spindle-shaped cells arranged in lobules in a myxoid or chondroid background. Two cases are presented here: 8, and 12-year-old patients, both with lesions in the proximal tibia. The first case showed an unusual feature: it was diaphyseal chondromyxoid fibroma. In the second case, the lesion was metaphyso-diaphyseal. The differential diagnosis includes chondroblastoma, myxoma, aneurysmal cyst as well as chondrosarcoma. A surgical conservative treatment with complete excision is recommended even in case of recurrence. PMID:15688891

  12. Dopamine-Mediated Sclerotization of Regenerated Chitin in Ionic Liquid

    Dongyeop X. Oh

    2013-09-01

    Full Text Available Chitin is a promising structural material for biomedical applications, due to its many advantageous properties and abundance in nature. However, its usage and development in the biomedical field have been stagnant, because of chitin’s poor mechanical properties in wet conditions and the difficulties in transforming it into an applicable form. To overcome these challenges, we created a novel biomimetic chitin composite. This regenerated chitin, prepared with ionic liquid, showed improved mechanical properties in wet conditions by mimicking insect cuticle and squid beak sclerotization, i.e., catechol-meditated cross-linking. By ionic liquid-based heat treatment, dopamine oxidation produced melanin-like compounds and dopamine-meditated cross-links without any solvent evaporation and oxidant utilization. The dopamine-meditated sclerotization increased the ultimate tensile strength (UTS of the regenerated chitin by 2.52-fold, measured after six weeks of phosphate-buffered saline (PBS submersion. In addition, the linear swelling ratio (LSR of the chitin film was reduced by about 22%. This strategy raises a possibility of using regenerated chitin as an artificial hard tissue in wet conditions.

  13. Indian Ocean Rim Cooperation

    Wippel, Steffen

    Since the mid-1990s, the Indian Ocean has been experiencing increasing economic cooperation among its rim states. Middle Eastern countries, too, participate in the work of the Indian Ocean Rim Association, which received new impetus in the course of the current decade. Notably Oman is a very active...

  14. Multifocal sclerotic BCG spondylitis in a 13-year-old girl

    A case is reported of multifocal BCG osteomyelitis in a 13-year-old girl. The lesions in the skull, ribs and in several vertebrae were mainly sclerotic and healed with antituberculotic therapy. The case is unusual because of the late onset, sclerotic changes, and involvement of the spine. (orig.)

  15. Rim inertial measuring system

    Groom, N. J.; Anderson, W. W.; Phillips, W. H. (Inventor)

    1981-01-01

    The invention includes an angular momentum control device (AMCD) having a rim and several magnetic bearing stations. The AMCD is in a strapped down position on a spacecraft. Each magnetic bearing station comprises means, including an axial position sensor, for controlling the position of the rim in the axial direction; and means, including a radial position sensor, for controlling the position of the rim in the radial direction. A first computer receives the signals from all the axial position sensors and computes the angular rates about first and second mutually perpendicular axes in the plane of the rim and computes the linear acceleration along a third axis perpendicular to the first and second axes. A second computer receives the signals from all the radial position sensors and computes the linear accelerations along the first and second axes.

  16. Postecdysis Sclerotization of Mouthparts of the Formosan Subterranean Termites (Isoptera: Rhinotermitidae).

    Kakkar, Garima; Chouvenc, Thomas; Su, Nan-Yao

    2016-04-01

    In termites, it is challenging to recognize the incidence of molting in workers because of their successive stationary molt, asynchronous molting among individuals, cryptic behavior, a soft and poorly sclerotized cuticle, and they immediately consume the shed exuvia of nestmates. This study describes a method in which the degree of sclerotization of the mouthparts in newly molted workers of the Formosan subterranean termite can be quantified and used to determine if an individual has recently molted, within a 36-h time frame. Changes in the tanning of mouthparts over time were used as a measure of the index of sclerotization in workers postmolting. Upon ecdysis, the primary point of articulation of the mandible already initiated sclerotization, which may allow the movement of the mandibles during the shedding of the exuvium. The sclerotization of the secondary point of articulation and the mandibular teeth, and the width of sclerotization of the mandibles, progressively increased until reaching a plateau around 36-h postecdysis, which imply that workers can regain some level of activity as early as 2 d after ecdysis. Our observations allowed for the determination of variables for the sclerotization of the mouthparts to easily identify workers that recently molted, and this method will be useful in future studies that focus on the molting activity of workers over time and space within a termite colony, in the scope of improving current control strategies for termite pests. PMID:26743216

  17. Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases.

    Lee, Seung Yun; Cardones, Adela R; Doherty, Joshua; Nightingale, Kathryn; Palmeri, Mark

    2015-11-01

    In this study, acoustic radiation force impulse (ARFI) and shear wave elasticity imaging (SWEI) were applied to the skin to investigate the feasibility of their use in assessing sclerotic skin diseases. Our motivation was to develop a non-invasive imaging technology with real-time feedback of sclerotic skin disease diagnosis. This paper shows representative results from an ongoing study, recruiting patients with and without sclerosis. The stiffness of the imaged site was evaluated using two metrics: mean ARFI displacement magnitude and bulk shear wave speed inside the region of interest (ROI). In a subject with localized graft versus host disease (GVHD), the mean ARFI displacement inside sclerotic skin was 61% lower (p types. We conclude ARFI and SWEI can successfully differentiate sclerotic lesions from normal dermis. PMID:26259888

  18. 激素性股骨头坏死硬化带与骨形态蛋白关系的研究%Study on the relationship between sclerosis rim and bone morphogenetic proteins of osteonecrosis of the femoral head

    石少辉; 李子荣; 王佰亮; 孙伟; 程立明; 潘琳; 王冉东

    2010-01-01

    目的 通过对股骨头坏死(ONFH)患者硬化带形成情况进行回顾性分析及其组织学观察,探讨骨形态蛋白(BMP4)与硬化带关系,为股骨头坏死个性化治疗提供理论依据.方法 2005年11月至2007年11月共治疗激素性ONFH全髋关节置换患者184髋,患者平均年龄(47±7)岁,依此把患者分为高(>54岁)、中(40~54岁)和低(<40岁)3个年龄组,分析比较3组患者硬化带形成比率.从184髋中选取部分股骨头标本,包括高年龄组患者股骨头18髋,低年龄组11髋,中年龄组股骨头标本20髋(有无硬化带形成者各10髋).股骨头冠状面正中剖开,在负重区和非负重区取材,行常规HE染色、苦味酸-天狼星红染色、电镜制备和BMP4蛋白免疫组化染色.BMP4蛋白免疫组化染色强度用图像分析软件计算其平均光密度.结果 硬化带在组织学上表现为骨小梁增粗,结构紊乱,但骨细胞结构同正常骨细胞,且处于高分泌状态.中年龄组ONFH患者硬化带形成比例为71.4%(105/147),显著高于低年龄组患者(45.5%,5/11)和高年龄组患者(38.5%,10/26)(P均<0.01).中年组患者股骨头BMP4平均光密度为0.32±0.14,明显高于低年龄组0.20±0.17和高年龄组0.19±0.27,且差异具有统计学意义(P均<0.05);中年龄组患者无硬化带形成者BMP4平均光密度分别为0.16±0.1l,有硬化带形成患者为0.28±0.13,差异具有统计学意义(P<0.01).有硬化带形成患者出现髋关节疼痛到关节置换时间为(49±11)个月,显著长于无硬化带形成者(15±2)个月,差异具有统计学意义(P<0.01).结论 ONFH患者硬化带形成与BMP4表达强弱呈正相关,BMP的高表达可能促进硬化带的形成.%Objectives To analyze retrospectively the formation and histological changes of sclerosis rim in patients with osteonecrosis of the femoral head ( ONFH), and to study the relationship between bone morphogenetic proteins (BMP4) and sclerosis rim, so as to acquire

  19. Reduced Antigenicity of Type I Collagen and Proteoglycans in Sclerotic Dentin

    Suppa, P.; Ruggeri, A.; Tay, F.R.; Prati, C.; Biasotto, M.; Falconi, M; Pashley, D.H.; Breschi, L.

    2006-01-01

    Antigenic alterations to the dentin organic matrix may be detected by an immunohistochemical approach. We hypothesized that alterations in the antigenicity of type I collagen and proteoglycans occur in sclerotic dentin under caries lesions. Transverse sections were prepared from carious teeth in the sclerotic zone and normal hard dentin. A double-immunolabeling technique was performed on these sections, with anti-type I collagen and anti-chondroitin 4/6 sulfate monoclonal primary antibodies. ...

  20. Effect of Induced Refractive Error and Nuclear Sclerotic Cataracts on Ishihara Colour Plate Testing

    Eneh AA; Rogalska T; Urton T; Schweitzer KD

    2014-01-01

    Objective: To determine the effect of induced refractive blur and nuclear sclerotic (NS) cataracts on Ishihara colour plate (ICP) scores. Design: Prospective evaluation of a diagnostic test Participants: Patients who presented to Hotel Dieu Hospital Eye clinic between January and March 2010 with either a lone diagnosis of nuclear sclerotic cataracts, or with no identified ocular disease with complete examination. Methods: Patients were divided into two groups: those having no id...

  1. RIMS Program Description.

    Kraepelien, Hans

    Computer routines for the translation of teacher-prepared mark sense forms to magnetic tape are described. The program, Receiving IMS (RIMS), is part of the Southwest Regional Laboratory's (SWRL) Instructional Management System (IMS). It accepts mark sense sheets from remotely located Xerox 660 scanner copiers and/or IMS update information from…

  2. Optimization Of Car Rim

    Mr. Sushant K. Bawne

    2015-10-01

    Full Text Available The essential of car wheel rim is to provide a firm base on which to fit the tyre. Its dimensions, shape should be suitable to adequately accommodate the particular tyre required for the vehicle. In this project a tyre of car wheel rim belonging to the disc wheel category is considered. Design is an important industrial activity which influences the quality of the product. The wheel rim is modeled by using modeling software catiav5r17. By using this software the time spent in producing the complex 3- D models and the risk involved in the design and manufacturing process can be easily minimized. So the modeling of the wheel rim is made by using CATIA. Later this CATIA modal is imported to ANSYS WORKBENCH 14.5 for analysis work. ANSYS WORKBENCH 14.5 is the latest software used for simulating the different forces, pressure acting on the component and also calculating and viewing the results. By using ANSYS WORKBENCH 14.5 software reduces the time compared with the method of mathematical calculations by a human. ANSYS WORKBENCH 14.5 static structural analysis work is carried out by considered three different materials namely aluminum alloy ,magnesium alloy and structural steel and their relative performances have been observed respectively. In addition to wheel rim is subjected to modal analysis, a part of dynamic analysis is carried out its performance is observed. In this analysis by observing the results of both static and dynamic analysis obtained magnesium alloy is suggested as best material.

  3. RIMS: Resource Information Management System

    Symes, J.

    1983-01-01

    An overview is given of the capabilities and functions of the resource management system (RIMS). It is a simple interactive DMS tool which allows users to build, modify, and maintain data management applications. The RIMS minimizes programmer support required to develop/maintain small data base applications. The RIMS also assists in bringing the United Information Services (UIS) budget system work inhouse. Information is also given on the relationship between the RIMS and the user community.

  4. Metabolic analysis of osteoarthritis subchondral bone based on UPLC/Q-TOF-MS.

    Yang, Gang; Zhang, Hua; Chen, Tingmei; Zhu, Weiwen; Ding, Shijia; Xu, Kaiming; Xu, Zhongwei; Guo, Yanlei; Zhang, Jian

    2016-06-01

    Osteoarthritis (OA), one of the most widespread musculoskeletal joint diseases among the aged, is characterized by the progressive loss of articular cartilage and continuous changes in subchondral bone. The exact pathogenesis of osteoarthritis is not completely clear. In this work, ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS) in combination with multivariate statistical analysis was applied to analyze the metabolic profiling of subchondral bone from 42 primary osteoarthritis patients. This paper described a modified two-step method for extracting the metabolites of subchondral bone from primary osteoarthritis patients. Finally, 68 metabolites were identified to be significantly changed in the sclerotic subchondral bone compared with the non-sclerotic subchondral bone. Taurine and hypotaurine metabolism and beta-alanine metabolism were probably relevant to the sclerosis of subchondral bone. Taurine, L-carnitine, and glycerophospholipids played a vital regulation role in the pathological process of sclerotic subchondral bone. In the sclerotic process, beta-alanine and L-carnitine might be related to the increase of energy consumption. In addition, our findings suggested that the intra-cellular environment of sclerotic subchondral bone might be more acidotic and hypoxic compared with the non-sclerotic subchondral bone. In conclusion, this study provided a new insight into the pathogenesis of subchondral bone sclerosis. Our results indicated that metabolomics could serve as a promising approach for elucidating the pathogenesis of subchondral bone sclerosis in primary osteoarthritis. Graphical Abstract Metabolic analysis of osteoarthritis subchondral bone. PMID:27074781

  5. O Rim Revisitado

    Barros Veloso, AJ

    1997-01-01

    O autor faz a recapitulação do percurso histórico que conduziu ao conhecimento moderno da fisiologia renale refere-se ao fascínio que esse conhecimento exerceu sobre os internistas no início da década de 60. Depois de realçar a importância do aparecimento da diálise no tratamento e no prognóstico da insuficiência renal, faz algumas considerações acerca do tratamento das glomerulopatias e dos mistérios que o rim ainda persiste em nos ocultar.

  6. CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS

    Taeko Nakamura-Wakatsuki

    2013-10-01

    Full Text Available Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fingers have not been reported to date. Mucin deposition in the sclerotic skin may be a predisposing factor in the induction of myxoid cyst on the scleroderma finger in our patient.

  7. Minocycline-induced orbital rim discoloration.

    Ballard, Tiffany N S; Briceño, César A

    2016-04-01

    A 20-year-old woman underwent lacrimal gland biopsy for unilateral swelling and was unexpectedly found to have olive-green discoloration of her orbital rim. Postoperative questioning revealed that as a teenager she had been treated for acne with minocycline, a semisynthetic tetracycline antibiotic and a first-line treatment for moderate and severe acne. While hyperpigmentation is a known side effect of minocycline, reports of pigmentation changes of the periorbital bones are relatively rare and could pose a diagnostic dilemma during surgery. PMID:26988772

  8. ISOLATED TUBERCULOSIS OF NAVICULAR BONE: A CASE REPORT

    Indudhara; Harish; Yenni

    2015-01-01

    Skeletal tuberculosis rare in foot. Bones generally involved are the spine ( D orso - lumbar), skull, shoulder girdle and hip bones. Involvement of the foot is infrequent. Very rare in navicular bone. A female of 23 years presented with swelling and pain in of right foot. X - ray showed lytic lesion with sclerotic margins. Biop...

  9. 1例硬化性滑膜肉瘤的临床病理观察%Clinicopathological features of sclerotic synovial sarcoma

    王昀; 王殿军; 贾金鹏

    2012-01-01

    , desmin and SMA. P53 positive cells accounted for 50%-75%. Reticulum fibers in sclerotic interstitial area were positively stained with AB while PAS staining was negative. FISH showed SS18(18qll.2) chromosome translocation. Conclusion Sclerotic SS is an extremely rare type of synovial sarcoma. Its differential diagnosis can be made with immunohistochemical staining and molecular detection from parosteal osteosarcoma, myositis ossificans, fibrosarcoma, desmoplastic fibroma of bone and hemangiopericytoma.

  10. Sclerotic fibroma (storiform collagenoma)-like stroma in a fibroadenoma of axillary accessory breast tissue.

    Val-Bernal, José Fernando; González-Vela, María Carmen; De Grado, Mauricio; Garijo, María Francisca

    2012-08-01

    Accessory breast tissue is a subcutaneous remnant persisting after normal embryological development of the breast. It occurs most frequently in the axilla. Fibroadenomas in axillary breast tissue are rare. We report the case of a 29-year-old female patient who presented a fibroadenoma arising in the accessory breast tissue of the right axillary fossa. The neoplasm showed foci of sclerotic fibroma-like stroma. The patient had no signs of Cowden's syndrome. To the best of our knowledge, a lesion of this kind has not been previously reported. This stromal change suggests an uncommon involutional phase of the fibroadenoma with production of sclerotic and hypocellular collagen. The lesion should be differentiated from extraneural perineuroma, from the changes in fibroadenomas in Cowden's syndrome, from sclerosing lobular hyperplasia (fibroadenomatoid mastopathy) and from pseudoangiomatous stromal hyperplasia. PMID:22804110

  11. Micromorphological and hardness analyses of human and bovine sclerotic dentin: a comparative study

    Gisela Muassab Castanho; Márcia Martins Marques; Juliana Barbosa Marques; Maitê André Camargo; Antonio Alberto De Cara

    2011-01-01

    The purpose of this study was to test the hypothesis that both human and bovine sclerotic dentin have similar hardness properties, in addition to similar micromorphological characteristics. Sixteen teeth (8 human and 8 bovine) exhibiting exposed dentin in the incisal edge and showing characteristics typical of sclerosis were used. Vickers surface microhardness testing was conducted. Three areas of the dentin surface of each specimen were selected. All teeth were processed for scanning electro...

  12. Portable basketball rim testing device

    Abbott, W. Bruce; Davis, Karl C.

    1993-01-01

    A portable basketball rim rebound testing device 10 is illustrated in two preferred embodiments for testing the rebound or energy absorption characteristics of a basketball rim 12 and its accompanying support to determine likely rebound or energy absorption charcteristics of the system. The apparatus 10 includes a depending frame 28 having a C-clamp 36 for releasably rigidly connecting the frame to the basketball rim 12. A glide weight 60 is mounted on a guide rod 52 permitting the weight 60 to be dropped against a calibrated spring 56 held on an abutment surface on the rod to generate for deflecting the basketball rim and then rebounding the weight upwardly. A photosensor 66 is mounted on the depending frame 28 to sense passage of reflective surfaces 75 on the weight to thereby obtain sufficient data to enable a processing means 26 to calculate the rebound velocity and relate it to an energy absorption percentage rate of the rim system 12. A readout is provided to display the energy absorption percentage.

  13. Analysis of the Rim Inertial Measuring System (RIMS)

    Joshi, S. M.

    1980-01-01

    Nonlinear equations of motion are derived for the rim inertial measuring system, which is mounted in a strapped down configuration on a carrier vehicle. The measurement and equations derived from angular rates and linear accelerations were interfaced with the dynamic model of a user defined carried vehicle. Two methods are presented for rate measurement, and the results of the nonlinear computer simulation are presented.

  14. The Sclerotic Scatter Limbal Arc Is More Easily Elicited under Mesopic Rather Than Photopic Conditions.

    Eric Denion

    Full Text Available We aimed to determine the limbal lighting illuminance thresholds (LLITs required to trigger perception of sclerotic scatter at the opposite non-illuminated limbus (i.e. perception of a light limbal scleral arc under different levels of ambient lighting illuminance (ALI.Twenty healthy volunteers were enrolled. The iris shade (light or dark was graded by retrieving the median value of the pixels of a pre-determined zone of a gray-level iris photograph. Mean keratometry and central corneal pachymetry were recorded. Each subject was asked to lie down, and the ALI at eye level was set to mesopic values (10, 20, 40 lux, then photopic values (60, 80, 100, 150, 200 lux. For each ALI level, a light beam of gradually increasing illuminance was applied to the right temporal limbus until the LLIT was reached, i.e. the level required to produce the faint light arc that is characteristic of sclerotic scatter at the nasal limbus.After log-log transformation, a linear relationship between the logarithm of ALI and the logarithm of the LLIT was found (p<0.001, a 10% increase in ALI being associated with an average increase in the LLIT of 28.9%. Higher keratometry values were associated with higher LLIT values (p = 0.008 under low ALI levels, but the coefficient of the interaction was very small, representing a very limited effect. Iris shade and central corneal thickness values were not significantly associated with the LLIT. We also developed a censored linear model for ALI values ≤ 40 lux, showing a linear relationship between ALI and the LLIT, in which the LLIT value was 34.4 times greater than the ALI value.Sclerotic scatter is more easily elicited under mesopic conditions than under photopic conditions and requires the LLIT value to be much higher than the ALI value, i.e. it requires extreme contrast.

  15. Datasets from label-free quantitative proteomic analysis of human glomeruli with sclerotic lesions

    Ying Zhang

    2015-09-01

    Full Text Available Human glomeruli with intermediate (i-GS and advanced (GS sclerotic lesions as well as the normal control (Nor were captured from laser microdissection, digested by trypsin and subjected to shotgun LC-MS/MS analysis (LTQ-Orbitrap XL. The label-free quantification was performed using the Normalized Spectral Index (SIN to assess the relative molar concentration of each protein identified in a sample. All the experimental data are shown in this article. The data is associated to the research article submitted to Journal of Proteomics [1].

  16. A digital image analyser for RIMS studies

    Resonance Ionisation Mass Spectrometry (RIMS) is now playing a vital role in various areas of physics and chemistry. A digital image analyser for quantitative analysis of RIMS experiments has been developed

  17. Bone

    Bone scanning provides information on the extent of primary bone tumors, on possible metastatic disease, on the presence of osteomyelitis prior to observation of roentgenographic changes so that earlier therapy is possible, on the presence of collagen diseases, on the presence of fractures not disclosed by x-ray films, and on the evaluation of aseptic necrosis. However, the total effect and contribution of bone scanning to the diagnosis, treatment, and ultimate prognosis of pediatric skeletal diseases is, as yet, unknown. (auth)

  18. Systematic Identification, Characterization and Target Gene Analysis of microRNAs Involved in Osteoarthritis Subchondral Bone Pathogenesis.

    Prasadam, Indira; Batra, Jyotsna; Perry, Samuel; Gu, Wenyi; Crawford, Ross; Xiao, Yin

    2016-07-01

    This study aimed to identify the microRNAs associated with sclerotic status of subchondral bone in the pathogenesis of osteoarthritis (OA). Total RNA was extracted from non-sclerotic and sclerotic OA subchondral bone from patients undergoing knee replacement surgeries. miRCURY™ LNA miRNA chip and qRT-PCR were used to profile and validate differential microRNA expression. In addition, we further confirmed profiles of altered miRNAs in an OA rat meniscectomy animal model and their putative targets of the miRNAs were predicted using ingenuity (IPA) software. Finally, five short-listed miRNAs were reactivated by transient in vitro overexpression (miRNA mimics) in subchondral bone osteoblasts and their phenotypes were assessed. Functional screening identified 30 differentiated miRNAs in sclerotic subchondral bone compared to non-sclerotic bone of OA patients. Data integration resulted in confirmation of the eight miRNAs, with aberrant expression in independent human OA bone sample set. In silico analysis (IPA) identified 732 mRNA transcripts as putative targets of the eight altered miRNAs, of which twenty genes were validated to be differentially expressed in sclerotic compared to non-sclerotic bone samples. Out of eight dysregulated miRNA's, five of them showed consistent time-dependent downregulation in a rat OA model. Furthermore, synthetic miR-199a-3p, miR-199a-5p, miR-590-5p, and miR-211-5p mimics rescued the abnormal osteoarthritic subchondral bone osteoblast gene expression and mineralization. We have identified four novel miRNAs that play important roles in subchondral bone pathogenesis in OA. Additional studies are required to develop these miRNAs into therapeutic modalities for OA. PMID:26944279

  19. CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts: preliminary results

    Objective: To evaluate CT-guided once-through bilateral percutaneous needle puncturing, aspiration and injection of sclerotic agents (ethanol) in treating bilateral multiple renal cysts. Methods: CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy was performed in 19 patients with bilateral multiple renal cysts. First, under CT guidance the puncture points and puncture routs were decided, then, puncturing, aspiration, rinsing and ethanol injection of the cysts were taken place by turn. The clinical results were analyzed. Results: bilateral percutaneous needle puncturing sclerotic therapy was successfully completed in all 19 cases. The whole procedure was well tolerated by all patients. The mean operative time was 23 minutes with a range of 20-35 minutes. No severe complications occurred. Conclusion: With proficient manipulation, CT-guided bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts can be smoothly carried out. The technique can reduced the number of sclerotherapy times, cut down the medical expenses and, therefore, get twofold results with half the effort. (authors)

  20. ISOLATED TUBERCULOSIS OF NAVICULAR BONE: A CASE REPORT

    Indudhara

    2015-05-01

    Full Text Available Skeletal tuberculosis rare in foot. Bones generally involved are the spine ( D orso - lumbar, skull, shoulder girdle and hip bones. Involvement of the foot is infrequent. Very rare in navicular bone. A female of 23 years presented with swelling and pain in of right foot. X - ray showed lytic lesion with sclerotic margins. Biopsy was done and histopathological diagnosis of tuberculosis was made.

  1. Imaging appearance of bone tumors of the maxillofacial region

    Razek, Ahmed Abdel Khalek Abdel

    2011-01-01

    This paper reviews the imaging appearance of benign and malignant bone tumors of the maxillofacial region. A benign bone tumor commonly appears as a well circumscribed lesion. The matrix of the tumor may be calcified or sclerotic. Malignancies often display aggressive characteristics such as cortical breakthrough, bone destruction, a permeative pattern and associated soft-tissue masses. Computed tomography scan is an excellent imaging modality for accurate localization of the lesion, characte...

  2. Tuberous sclerosis with giant renal angiomyolipoma and sclerotic skeletal lesions in a geriatric patient: role of imaging

    Rashmi M. Nagaraju

    2015-08-01

    Full Text Available Tuberous sclerosis is a rare inherited neurocutaneous syndrome, which has multisystem involvement. We present a geriatric female patient with chronic abdominal pain who was diagnosed with giant renal angiomyolipoma (AML and multiple sclerotic skeletal lesions. Radiological imaging played an important role in identifying these two features and diagnosing tuberous sclerosis in our case. [Int J Res Med Sci 2015; 3(8.000: 2145-2149

  3. Thermoviscous Coating and Rimming Flow

    Leslie, G. A.

    2012-10-22

    A comprehensive description is obtained of steady thermoviscous (that is, with temperature-dependent viscosity) coating and rimming flow of a thin film of fluid on a uniformly rotating horizontal cylinder that is uniformly hotter or colder than the surrounding atmosphere. It is found that, as in the corresponding isothermal problem, there is a critical solution with a corresponding critical load (which depends, in general, on both the Biot number B and the thermoviscosity number V) above which no \\'full-film\\' solutions corresponding to a continuous film of fluid covering the entire outside or inside of the cylinder exist. The effect of thermoviscosity on both the critical solution and the full-film solution with a prescribed load is described. In particular, there are no full-film solutions with a prescribed load M for any value of B when for positive V and when M ≥ f-1/2 Mc0 for negative V, where is a monotonically decreasing function of V and M c0 ≃ 4.44272 is the critical load in the constant-viscosity case. It is also found that, for the exponential viscosity model, when the prescribed load satisfies M < 1.50315 there is a narrow region of the B-V parameter plane in which backflow occurs. © 2012 The Author. Published by Oxford University Press; all rights reserved. For Permissions, please email: journals.permissions@oup.com.

  4. How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.

    Acuna, Claudio; Liu, Xinran; Südhof, Thomas C

    2016-08-17

    RIMs and RIM-binding proteins (RBPs) are evolutionary conserved multidomain proteins of presynaptic active zones that are known to recruit Ca(2+) channels; in addition, RIMs perform well-recognized functions in tethering and priming synaptic vesicles for exocytosis. However, deletions of RIMs or RBPs in mice cause only partial impairments in various active zone functions and have no effect on active zone structure, as visualized by electron micrographs, suggesting that their contribution to active zone functions is limited. Here, we show in synapses of the calyx of Held in vivo and hippocampal neurons in culture that combined, but not individual, deletions of RIMs and RBPs eliminate tethering and priming of synaptic vesicles, deplete presynaptic Ca(2+) channels, and ablate active zone complexes, as analyzed by electron microscopy of chemically fixed synapses. Thus, RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions. PMID:27537484

  5. Subchondral Insufficiency Fracture of the Femoral Head Caused by Excessive Lateralization of the Acetabular Rim

    Kimura, Tetsuya; Goto, Tomohiro; Hamada, Daisuke; Tsutsui, Takahiko; Wada, Keizo; Fukuta, Shoji; Nagamachi, Akihiro; Sairyo, Koichi

    2016-01-01

    We present a case of a 53-year-old woman with subchondral insufficiency fracture (SIF) of the femoral head without history of severe osteoporosis or overexertion. Plain radiographs showed acetabular overcoverage with excessive lateralization of the acetabular rim. A diagnosis of SIF was made by typical MRI findings of SIF. The lesion occurred at the antipodes of the extended rim. Increased mechanical stress over the femoral head due to impingement against the excess bone was suspected as a cause of SIF. The distinct femoral head deformity is consistent with this hypothesis. This is the first report of SIF associated with acetabular overcoverage. PMID:27293935

  6. Histologia e ultraestrutura do rim e rim cefálico do pacu

    Gerlane M. Costa

    2012-05-01

    Full Text Available O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de cada órgão com o uso de microscopia de luz e microscopia eletrônica de transmissão. O resultado da análise macroscópica mostrou que a localização do rim e rim cefálico são as mesmas encontradas na maioria dos teleósteos. O rim apresentou uma forma em "H", onde a região média se expandia sobre a bexiga natatória. O rim cefálico se apresentou como uma dilatação na região cranial do rim, mostrando-se bem visível. Na microscopia eletrônica de transmissão também foram observadas similaridades ultraestruturais com outros teleósteos. Observando nossos resultados concluímos que histologicamente e ultraestruturalmente, os órgãos linfóides rim e rim cefálico de Piaractus mesopotamicus são similares aos de outros teleósteos.

  7. Echogenic rim of hepatic hemangioma on abdominal ultrasound

    To investigate the association between the size of the hepatic hemangioma and the shape and thickness of the echogenic rim of hepatic hemangioma on abdominal ultrasound. We examined 47 cases (M:F=24:23, mean age 47.1) of hepatic hemangiomas with echogenic rim on abdominal ultrasound during the past 2 years. Radiologic findings were retrospectively reviewed in terms of completeness and thickness of echogenic rim. If echogenic rim showed even thickness, it was measured. But if not, the maximum and minimum thickness of the rim was measured. The association between the size of hemangioma and the completeness and thickness of the echogenic rim were analyzed statistically. Of the 47 cases, complete echogenic rim and incomplete echogenic rim were obtained in 29 (62%) and 18 (38%) cases, respectively. Twenty-two cases of hemangioma were less than 2 cm in diameter, and their distribution according to echogenic rim were as follows: complete echogenic rim (17/20, 91% mean thickness 2.2 cm) and uneven thickness with complete echogenic rim (3/20, 15%, range:2.0-6.1 mm). Twenty-five hemangiomas were larger than 2 cm in diameter and their distribution according to echogenic rim were as follows: complete echogenic rim (n=9, 34%), incomplete echogenic rim (n=16, 64%0,even thickness with complete echogenic rim (3/9, 33%, mean thickness 2.2 mm) and uneven thickness with complete echogenic rim (6/9,67%, range: 2.0-7.6 mm). In statistical analysis, hemangiomas more than 2 cm in diameter were more likely to have incomplete echogenic rim (p<0.05) than those of less than 2 cm; hemangiomas more than with more than 2 cm in diameter and complete echogenic rim showed uneven thickness of echogenic rim (p<0.05), more often than those of less than 2 cm diameter. Hemangiomas with more than 2 cm in diameter showed more frequent incomplete echogenic rim than those of less than 2 cm in diameter, which had more frequent complete echogenic rim. Hemangiomas with complete echogenic rim and even rim

  8. Reaction kinetics of dolomite rim growth

    Helpa, V.; Rybacki, E.; Abart, R.; Morales, L. F. G.; Rhede, D.; Jeřábek, P.; Dresen, G.

    2014-04-01

    Reaction rims of dolomite (CaMg[CO3]2) were produced by solid-state reactions at the contacts of oriented calcite (CaCO3) and magnesite (MgCO3) single crystals at 400 MPa pressure, 750-850 °C temperature, and 3-146 h annealing time to determine the reaction kinetics. The dolomite reaction rims show two different microstructural domains. Elongated palisades of dolomite grew perpendicular into the MgCO3 interface with length ranging from about 6 to 41 µm. At the same time, a 5-71 µm wide rim of equiaxed granular dolomite grew at the contact with CaCO3. Platinum markers showed that the original interface is located at the boundary between the granular and palisade-forming dolomite. In addition to dolomite, a 12-80 µm thick magnesio-calcite layer formed between the dolomite reaction rims and the calcite single crystals. All reaction products show at least an axiotactic crystallographic relationship with respect to calcite reactant, while full topotaxy to calcite prevails within the granular dolomite and magnesio-calcite. Dolomite grains frequently exhibit growth twins characterized by a rotation of 180° around one of the equivalent axis. From mass balance considerations, it is inferred that the reaction rim of dolomite grew by counter diffusion of MgO and CaO. Assuming an Arrhenius-type temperature dependence, activation energies for diffusion of CaO and MgO are E a (CaO) = 192 ± 54 kJ/mol and E a (MgO) = 198 ± 44 kJ/mol, respectively.

  9. [Unilateral visual field defect due to optic nerve compression by sclerotic internal carotid artery: a case report].

    Uchino, M; Nemoto, M; Ohtsuka, T; Kuramitsu, T; Isobe, Y

    1999-02-01

    A case of unilateral visual field defect due to optic nerve compression by a sclerotic internal carotid artery was reported. A 71-year-old woman was admitted to our department because of constricted visual field of the right eye. MRI showed elevation of the right optic nerve compressed by an internal carotid artery. The right carotid angiography revealed elevation and distortion of the C1-2 portion. Frontal craniotomy was carried out and the optic nerve was visualized on this side. The right optic nerve was found to have been compressed by the sclerotic internal carotid artery. The optic canal was then unroofed. The post-operative course was uneventful. The visual field was improved. When last seen 6 months after surgery, her visual field remained in the improved condition. Nasal field abnormalities are most frequently encountered in retinal and anterior optic nerve pathology. Our success in improving the visual field disturbance may be accounted for by the fact that the preoperative period was short and the operation was performed before atrophy of ocular fundi occurred. Nasal field loss caused by intracranial lesions of the optic pathway is rare. It is probably impossible to determine degree of the symptomatology caused by direct-pressure compression as opposed to that caused by ischemia secondary to occlusion of small arterial supply branches. Vascular compressive neuropathy of optic nerve should not be diagnosed simply by the radiological finding of the optic nerve dislocation. However, optic nerve compression by surrounding arteries should be remembered as one of the possible causes of visual field defect which needs to be treated surgically. PMID:10065453

  10. Effects of altered catecholamine metabolism on pigmentation and physical properties of sclerotized regions in the silkworm melanism mutant.

    Liang Qiao

    Full Text Available Catecholamine metabolism plays an important role in the determination of insect body color and cuticle sclerotization. To date, limited research has focused on these processes in silkworm. In the current study, we analyzed the interactions between catecholamines and melanin genes and their effects on the pigmentation patterns and physical properties of sclerotized regions in silkworm, using the melanic mutant melanism (mln silkworm strain as a model. Injection of β-alanine into mln mutant silkworm induced a change in catecholamine metabolism and turned its body color yellow. Further investigation of the catecholamine content and expression levels of the corresponding melanin genes from different developmental stages of Dazao-mln (mutant and Dazao (wild-type silkworm revealed that at the larval and adult stages, the expression patterns of melanin genes precipitated dopamine accumulation corresponding to functional loss of Bm-iAANAT, a repressive effect of excess NBAD on ebony, and upregulation of tan in the Dazao-mln strain. During the early pupal stage, dopamine did not accumulate in Dazao-mln, since upregulation of ebony and black genes led to conversion of high amounts of dopamine into NBAD, resulting in deep yellow cuticles. Scanning electron microscope analysis of a cross-section of adult dorsal plates from both wild-type and mutant silkworm disclosed the formation of different layers in Dazao-mln owing to lack of NADA, compared to even and dense layers in Dazao. Analysis of the mechanical properties of the anterior wings revealed higher storage modulus and lower loss tangent in Dazao-mln, which was closely associated with the altered catecholamine metabolism in the mutant strain. Based on these findings, we conclude that catecholamine metabolism is crucial for the color pattern and physical properties of cuticles in silkworm. Our results should provide a significant contribution to Lepidoptera cuticle tanning research.

  11. Rim-spoke composite flywheels: Stress and vibration analysis

    Chamis, C. C.; Kiraly, L. J.

    1976-01-01

    Elementary relations are described to determine the material utilization efficiency of a thin wall rim composite flywheel over other configurations. An algorithm is generated for the automatic selection of the optimum composite material for a given thin rim flywheel environment. Subsequently, the computer program NASTRAN is used to perform a detailed stress and vibration analysis of thin wall cylindrical shell rim spoke, single rim and multirim composite flywheels for a specific application.

  12. Managing oil logistics around the Baltic Rim

    Finland's Neste Group is a major player in the oil business in the Baltic area. Neste tankers and petroleum product logistics services comprehensively serve the region. Neste's main Baltic Rim terminal outside Finland is located at Muuga close to the Estonian capital, Tallinn. This will be joined by one in Riga in Latvia at the end of this year. A terminal for St. Petersburg is in the planning stage

  13. Unusual Bilateral Rim Fracture in Femoroacetabular Impingement

    Claudio Rafols

    2015-01-01

    Full Text Available This is a report of one case of bilateral acetabular rim fracture in association with femoroacetabular impingement (FAI, which was treated with a hip arthroscopic procedure, performing a partial resection, a labral reinsertion, and a subsequential internal fixation with cannulated screws. Up to date, there are in the literature only two reports of rim fracture and “os acetabuli” in association with FAI. In the case we present, the pincer and cam resection were performed without complications; the technique used was published previously. With this technique the head of the screw lays hidden by the reattached labrum. We removed partially the fractured rim fragment and the internal fixation of the remaining portion was achieved with a screw. In the event of a complete resection of the fragment, it would have ended with a LCE angle of 18° and a high probability of hip instability. We believe that this bilateral case helps establish the efficacy and reproducibility of the technique described by Larson.

  14. Hypercalcemia and altered biochemical bone markers in post-bone marrow transplantation osteopetrosis: a case report and literature review.

    Kulpiya, Alisa; Mahachoklertwattana, Pat; Pakakasama, Samart; Hongeng, Suradej; Poomthavorn, Preamrudee

    2012-08-01

    Autosomal recessive osteopetrosis is a rare disorder of bone resorption defect that results in generalized sclerotic bones and bone marrow failure. Allogeneic BMT is the only treatment for cure. One of the complications following a successful BMT is hypercalcemia that is a unique complication in this group of patients. We report a three-yr-old boy with osteopetrosis who developed hypercalcemia following the successful BMT. His maximal calcium level was 13.3 mg/dL. Markedly increased both bone formation and resorption markers were demonstrated along with hypercalcemia. These findings indicated an active donor-derived osteoclastic function and thus bone resorption following the successful donor engraftment in the patient. Treatment with hyperhydration, furosemide and bone resorption inhibitors, calcitonin, and bisphosphonate led to normalization of the serum calcium level. Bone resorption but not bone formation marker was persistently elevated despite having normocalcemia during a 16.5-month follow-up period. PMID:21323826

  15. Oculopharyngeal Weakness, Hypophrenia, Deafness, and Impaired Vision: A Novel Autosomal Dominant Myopathy with Rimmed Vacuoles

    Chen, Ting; Lu, Xiang-Hui; Wang, Hui-Fang; Ban, Rui; Liu, Hua-Xu; Shi, Qiang; Wang, Qian; Yin, Xi; Pu, Chuan-Qiang

    2016-01-01

    Background: Myopathies with rimmed vacuoles are a heterogeneous group of muscle disorders with progressive muscle weakness and varied clinical manifestations but similar features in muscle biopsies. Here, we describe a novel autosomal dominant myopathy with rimmed vacuoles in a large family with 11 patients of three generations affected. Methods: A clinical study including family history, obstetric, pediatric, and development history was recorded. Clinical examinations including physical examination, electromyography (EMG), serum creatine kinase (CK), bone X-rays, and brain magnetic resonance imaging (MRI) were performed in this family. Open muscle biopsies were performed on the proband and his mother. To find the causative gene, the whole-exome sequencing was carried out. Results: Disease onset was from adolescence to adulthood, but the affected patients of the third generation presented an earlier onset and more severe clinical manifestations than the older generations. Clinical features were characterized as dysarthria, dysphagia, external ophthalmoplegia, limb weakness, hypophrenia, deafness, and impaired vision. However, not every patient manifested all symptoms. Serum CK was mildly elevated and EMG indicated a myopathic pattern. Brain MRI showed cerebellum and brain stem mildly atrophy. Rimmed vacuoles and inclusion bodies were observed in muscle biopsy. The whole-exome sequencing was performed, but the causative gene has not been found. Conclusions: We reported a novel autosomal dominant myopathy with rimmed vacuoles characterized by dysarthria, dysphagia, external ophthalmoplegia, limb weakness, hypophrenia, deafness, and impaired vision, but the causative gene has not been found and needs further study. PMID:27453229

  16. Bleomycin-induced epithelial–mesenchymal transition in sclerotic skin of mice: Possible role of oxidative stress in the pathogenesis

    Zhou, Cheng-Fan, E-mail: zhouchengfan@sohu.com [Institute of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022 (China); Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032 (China); Zhou, Deng-Chuan [Department of Emergency Medicine and Critical Care Medicine, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022 (China); Zhang, Jia-Xiang; Wang, Feng; Cha, Wan-Sheng [Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032 (China); Wu, Chang-Hao [Department of Biochemistry and Physiology, Faculty of Health and Medical Sciences, University of Surrey (United Kingdom); Zhu, Qi-Xing, E-mail: zqxing@yeah.net [Institute of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022 (China); Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032 (China)

    2014-06-15

    Epithelial–mesenchymal transition (EMT) derived myofibroblasts are partly responsible for the increased collagen synthesis and deposition that occur in tissue fibrosis; however EMT occurrence in skin fibrosis and its mechanism remain unknown. The aim of this study was to investigate whether epithelial cells undergo EMT and determine the role of oxidative stress in this process. BALB/c mice were subcutaneously injected with bleomycin (BLM) or phosphate buffer saline (PBS) into the shaved back daily for 2, 3, and 4 weeks. Skin collagen deposition was evaluated by histopathology and Western blotting. EMT characteristics in the skin were determined by histopathology and immunofluorescent staining for E-cadherin and vimentin, which were further evaluated by Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR). To investigate the role of oxidative stress in EMT, the antioxidant N-acetylcysteine (NAC) was intraperitoneally (100 mg/kg body weight/day) injected daily for 3 weeks. The epithelial suprabasal cells were detached from the basement membrane zone (BMZ) in the sclerotic skin treated with BLM. Immunofluorescent staining indicated vimentin-positive epithelial cells frequently occurring in the thickened epidermis of BLM-treated mice. Western blotting and RT-PCR showed that the expression of E-cadherin was significantly decreased but that of vimentin significantly increased in the skin treated with BLM. NAC attenuated BLM induced oxidative damage, changes in E-cadherin and vimentin expressions and collagen deposition in the sclerotic skin of mice. This study provides the first evidence that BLM induces the EMT of the epithelial cells superficial to the basement membrane zone in the skin fibrosis. Oxidative stress may contribute, at least in part, to BLM induced EMT and skin fibrosis in mice. - Highlights: • We provided the first evidence that EMT occurred in BLM-induced skin fibrosis. • Epithelial cells superficial to the BMZ underwent

  17. Bleomycin-induced epithelial–mesenchymal transition in sclerotic skin of mice: Possible role of oxidative stress in the pathogenesis

    Epithelial–mesenchymal transition (EMT) derived myofibroblasts are partly responsible for the increased collagen synthesis and deposition that occur in tissue fibrosis; however EMT occurrence in skin fibrosis and its mechanism remain unknown. The aim of this study was to investigate whether epithelial cells undergo EMT and determine the role of oxidative stress in this process. BALB/c mice were subcutaneously injected with bleomycin (BLM) or phosphate buffer saline (PBS) into the shaved back daily for 2, 3, and 4 weeks. Skin collagen deposition was evaluated by histopathology and Western blotting. EMT characteristics in the skin were determined by histopathology and immunofluorescent staining for E-cadherin and vimentin, which were further evaluated by Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR). To investigate the role of oxidative stress in EMT, the antioxidant N-acetylcysteine (NAC) was intraperitoneally (100 mg/kg body weight/day) injected daily for 3 weeks. The epithelial suprabasal cells were detached from the basement membrane zone (BMZ) in the sclerotic skin treated with BLM. Immunofluorescent staining indicated vimentin-positive epithelial cells frequently occurring in the thickened epidermis of BLM-treated mice. Western blotting and RT-PCR showed that the expression of E-cadherin was significantly decreased but that of vimentin significantly increased in the skin treated with BLM. NAC attenuated BLM induced oxidative damage, changes in E-cadherin and vimentin expressions and collagen deposition in the sclerotic skin of mice. This study provides the first evidence that BLM induces the EMT of the epithelial cells superficial to the basement membrane zone in the skin fibrosis. Oxidative stress may contribute, at least in part, to BLM induced EMT and skin fibrosis in mice. - Highlights: • We provided the first evidence that EMT occurred in BLM-induced skin fibrosis. • Epithelial cells superficial to the BMZ underwent

  18. Linhas escleróticas metafisárias em crianças e adolescentes em uso de alendronato Sclerotic metaphyseal lines in children and adolescents treated with alendronate

    Érika C.C. Silva

    2010-06-01

    Full Text Available INTRODUÇÃO: Os bisfosfonatos inibem a reabsorção óssea pela interferência na ação dos osteoclastos. Dentre os efeitos adversos, as linhas escleróticas em metáfise de ossos longos são descritas como principal alteração radiográfica na faixa etária pediátrica. OBJETIVO: Avaliar a frequência de alterações radiográficas causadas pelo alendronato utilizado em crianças e adolescentes com baixa densidade óssea ou calcinose. PACIENTES E MÉTODOS: Foi realizado um estudo do tipo coorte retrospectiva analisando-se prontuários de 21 pacientes que fizeram uso de alendronato semanal por no mínimo 10 meses. Os pacientes realizaram radiografias de ossos longos antes do início do alendronato e aproximadamente um ano após o seu uso. RESULTADOS: Onze pacientes (52,3% apresentaram linhas escleróticas em metáfise dos ossos longos. A localização mais frequente foi em tíbia (8/11 pacientes, seguida de fêmur (7/11, úmero (6/11, rádio (4/11, ulna (3/11 e fíbula (2/11. Nenhum paciente apresentou regress��o das alterações radiográficas durante o tempo de evolução (até 1,1 ano após a suspensão do alendronato. CONCLUSÃO: Se usado com critério, o alendronato é seguro e as alterações radiográficas não mostraram ter um significado mais importante.INTRODUCTION: Bisphosphonates inhibit bone resorption by interfering with the action of osteoclasts. Among the adverse effects, sclerotic lines observed in the metaphysis of long bones have been described as the main imaging finding in pediatric patients. OBJECTIVE: To evaluate the frequency of radiographic changes caused by alendronate in children and adolescents with low bone density or calcinosis. PATIENTS AND METHODS: We conducted a cross-sectional study with 21 patients who were treated with once-weekly alendronate for at least 10 months. Patients underwent x-rays of long bones before the start of alendronate and approximately one year after its use. RESULTS: Eleven patients

  19. Analysis of a Carbon Fibre Rim : Student Formula

    Uyttersprot, Bryan

    2015-01-01

    This master’s thesis is within the context of a formula race competition between universities. The main goal is to replace the modern rims of the TAMK Student Formula car by lighter and more efficient rims. To achieve this goal, important topics such as general rim design, tyre forces, tyre moments, strength of materials, fatigue and mechanical properties of carbon fibre were examined. Carbon fibre was applied because of its decent strength, weight and fatigue characteristics. Two possib...

  20. Histologia e ultraestrutura do rim e rim cefálico do pacu

    Gerlane M. Costa; ANA R DE LIMA; Mendelson G. de Lima; José R Kfoury Jr

    2012-01-01

    O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de...

  1. Bone tumors with an associated pathologic fracture: Differentiation between benign and malignant status using radiologic findings

    To determine whether benign and malignant bone tumors with associated pathologic fractures can be differentiated using radiologic findings. Seventy-eight patients (47 men and 31 women, age range: 1-93 years) with a bone tumor and an associated pathologic fracture from 2004 to 2013 constituted the retrospective study cohort. The tumor size, margin, and enhancement patterns; the presence of sclerotic margin, the peritumoral bone marrow, soft tissue edema, extra-osseous soft tissue mass, intratumoral cystic/hemorrhagic/necrotic regions, mineralization/sclerotic regions, periosteal reaction and its appearance; and cortical change and its appearance were evaluated on all images. Differences between the imaging characteristics of malignant and benign pathologic fractures were compared using Pearson's chi-square test and the 2-sample t-test. There were 22 benign and 56 malignant bone tumors. Some factors were found to significantly differentiate between benign and malignant tumors; specifically, ill-defined tumor margin, the presence of sclerotic tumor margin and an extra-osseous soft tissue mass, the absence of cystic/necrotic/hemorrhagic portions in a mass, the homogeneous enhancement pattern, and the presence of a displaced fracture and of underlying cortical change were suggestive of malignant pathologic fractures. Some imaging findings were helpful for differentiating between benign and malignant pathologic fractures

  2. Bone tumors with an associated pathologic fracture: Differentiation between benign and malignant status using radiologic findings

    Bae, Ji Hyun; Lee, In Sook; Song, You Seon [Pusan National University School of Medicine, Pusan National University Hospital, Busan (Korea, Republic of); Kim, Jeung Il [Dept. of Radiology, Yeungnam University College of Medicine, Yeungnam University Medical Center, Daegu (Korea, Republic of); Lee, Moon Sung [Dept. of Radiology, Keimyung University College of Medicine, Dongsan Medical Center, Daegu (Korea, Republic of); Lee, Young Hwan [Dept. of Radiology, Catholic University of Daegu College of Medicine, Daegu Catholic University Hospital, Daegu (Korea, Republic of); Song, Jong Woon [Dept. of Radiology, Inje University College of Medicine, Haeundae Paik Hospital, Busan (Korea, Republic of)

    2015-10-15

    To determine whether benign and malignant bone tumors with associated pathologic fractures can be differentiated using radiologic findings. Seventy-eight patients (47 men and 31 women, age range: 1-93 years) with a bone tumor and an associated pathologic fracture from 2004 to 2013 constituted the retrospective study cohort. The tumor size, margin, and enhancement patterns; the presence of sclerotic margin, the peritumoral bone marrow, soft tissue edema, extra-osseous soft tissue mass, intratumoral cystic/hemorrhagic/necrotic regions, mineralization/sclerotic regions, periosteal reaction and its appearance; and cortical change and its appearance were evaluated on all images. Differences between the imaging characteristics of malignant and benign pathologic fractures were compared using Pearson's chi-square test and the 2-sample t-test. There were 22 benign and 56 malignant bone tumors. Some factors were found to significantly differentiate between benign and malignant tumors; specifically, ill-defined tumor margin, the presence of sclerotic tumor margin and an extra-osseous soft tissue mass, the absence of cystic/necrotic/hemorrhagic portions in a mass, the homogeneous enhancement pattern, and the presence of a displaced fracture and of underlying cortical change were suggestive of malignant pathologic fractures. Some imaging findings were helpful for differentiating between benign and malignant pathologic fractures.

  3. Pattern of onychomycosis--a RIMS study.

    Pukhrambam, Pratita Devi; Devi, Kh Ranjana; Singh, Ng Brajachand

    2011-06-01

    Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts or non-dermatophytes moulds. In this study, 500 patients suspected of having onychomycosis reffered from the out patient department (OPD), Dermatology, Regional Institute of Medical Sciences (RIMS) Hospital Imphal Manipur during the period from January 2007 to December 2008 were processed in the Department of Microbiology RIMS. Nail clippings or scrapings depending on the variety of onychomycosis were collected with sterile blades under all aseptic measures. Specimens were put up for 10% KOH mount, fungal cultures on two sets of SDA (Sabouraud's dextrose agar) incorporated with antibiotics and lactophenol cotton blue preparation (LCB) from the cultures and examined microscopically. Slide cultures were also put up if necessary. Out of 500 samples processed, a total of 444 (88.8%) were positive for the various fungi. The positive fungi were dermatophytes 258 (58.1%), non-dermatophytes 139 (31.3%), yeasts and yeast-like 17 (3.8%) and mixed fungal isolates 30 (6.7%). Of the 230 males and 270 females studied,193 (83.9%) males and 251 (92.9%) females respectively were positive for various fungi causing onychomycosis. Maximum number of suspected cases were in the age group of 21-30 years. Among the dermatophytes, Trichophyton species (spp.) 250 (50%) was the commonest isolate followed by Epidermophyton spp. 8 (1.6%). Among the non-dermatophytes, Aspergillus spp. 70 (14%) was the commonest followed by Penicillium spp. 24 (4.8%), Acremonium spp. 9 (1.8%), Fusarium spp. 8 (1.6%), Curvularia spp. 7 (1.4%), Alternaria spp. 5 (1%), Scopulariopsis spp. 4 (0.8%), Cladosporium spp. 4 (0.8%), Nigrospora spp. 2 (0.4%), Mucor spp. 1 (0.2%), Paecilomyces spp. 1 (0.2%), Pseudallescheria spp. (0.2%), Rhizopus spp. 1 (0.2%), Verticillium spp. 1 (0.2%), Exophiala jeanselmei 1 (0.2%). Among the yeast and yeast-like i.e. Candida spp. 15, Geotrichum spp. 1, Rhodotorula spp. 1 were 17 (3.8%), mixed fungal isolates 30

  4. LSRA STS Tire Test - on rim

    1995-01-01

    From 1993 to 1995, in conjunction with other NASA centers, NASA Dryden Flight Research Center, Edwards, California, used a Convair CV-990 airplane as a Landing Systems Research Aircraft (LSRA) to perform Space Shuttle tire tests. The results provided the Space Shuttle Program with data to support its flight rules and enabled it to resurface a grooved runway at Kennedy Space Center that had added unnecessary wear to the Space Shuttle tires. Tests were done using a unique fixture mounted in the center of the CV-990 fuselage, between the main landing gear. Landing gear systems from other aircraft could be attached to the test fixture, which lowered them to the runway surface during actual landings. The LSRA had the ability to reproduce the loads and speeds of the other aircraft, as well as simulate crosswind landing conditions in a safe, controlled environment. The video clip shows a landing on the concrete runway at Edwards, California on August 11, 1995, which concluded the Space Shuttle gear research program. As the Space Shuttle tire was lowered onto the surface, it was destroyed almost instantly. The rim scraped on the concrete, and stopped rolling as it became flat. It heated up and left a flaming trail of hot rubber and aluminum alloy particles. Notice how the fire quickly went out as the test gear was raised, indicating a safer condition than prevailed in a lakebed landing.

  5. Computational fluid dynamics simulation of a rim driven thruster

    Dubas, Aleksander J.; Bressloff, N. W.; Fangohr, H.; Sharkh, S.M.

    2011-01-01

    An electric rim driven thruster is a relatively new marine propulsion device that uses a motor in its casing to drive a propeller by its rim and the fluid dynamics associated with their operation have not been fully investigated. There are many interacting flow features that make up the flow field of a rim driven thruster that pose a number of challenges when it comes to simulating the device using computational fluid dynamics. The purpose of this work is to develop a computational fluid dyna...

  6. Business Strategy Analysis of RIM in China's Smartphone Industry

    Chen, Lei

    2011-01-01

    China, the biggest mobile phone market in the world, is crucial for the future of Research In Motion (RIM). While RIM entered China’s market in 2006, its market share is still very small in China. The launch of 3G amid the restructuring of China’s telecom industry proved crucial to the company’s development. RIM has partnered with all mobile operators in China to provide BlackBerry Enterprise Service and BlackBerry Internet Service to both business and individual users. It has gained a compet...

  7. Learning from California and the Pacific Rim

    Heavy oils are found in 10 of the 14 largest oilfields in Alaska and California. In the US west coast region, petroleum demand is dominated by light transport fuels, and there is a lack of a discrete and conspicuous heavy oil market. The structure and behavior of west coast petroleum markets, and their interactions with crude-oil and petroleum product markets elsewhere on the Pacific Rim are discussed with regard to how the market for growing volumes of western Canadian heavy oils might evolve. An analysis of crude oil prices versus API gravity demonstrates the price penalties on oil of low gravity, high sulfur, and high transport cost. Prices at the high gravity end tend to correlate closely with Asian light crude and unfinished gasoline prices. The heaviest crudes are priced in competition with other chemically similar residual oils for direct fuel use, blending, or refinery feedstock. The biggest component of the west coast heavy oil market is bunker fuel. The market value of heavy crudes in the west coast is thus determined by regional supply and demand for heavy hydrocarbon molecules, whatever the source. The west coast is not a promising market for Canadian heavy crudes, and exports to Asia would have to compete both with residual oils from Asia and the US west coast and with California heavy crudes. US west coast production peaked in 1989 and regional production can be expected to decline further in average gravity. New production from known but undeveloped heavy oil pools near Prudhoe Bay or in the California offshore could be expected to postpone the need for imports to the west coast and to depress prices. A removal of the Alaska crude oil export ban could improve the west coast heavy oil market. 5 refs., 2 figs., 1 tab

  8. The natural history of disappearing bone tumours and tumour-like conditions

    We describe 27 cases of bone tumours or tumour-like lesions where there was spontaneous regression. The follow-up period was 2.8-16.7 years (average, 7.0 years). Fourteen of these cases were no longer visible on plain radiographs. Histological diagnosis included exostosis, eosinophilic granuloma, fibrous dysplasia, fibrous cortical defect, non-ossifying fibroma, osteoid osteoma and bone island. Most cases began to reduce in adolescence or earlier, although sclerotic type lesions showed their regression in older patients. All lesions thought to be eosinophilic granuloma began to regress after periods of less than 3 months, while the duration of the other lesions showed wide variation (1-74 months). As resolution of the lesions took between 2 and 79 months (mean, 25.0 ± 20.3 months) we consider that the most likely mechanism was recovery of normal skeletal growth control. In exostosis with fracture, alteration of vascular supply may contribute to growth arrest, but not to subsequent remodelling stage. In inflammatory-related lesions such as eosinophilic granuloma, cessation of inflammation may be the mechanism of growth arrest, whilst temporary inflammation may stimulate osteogenic cells engaged in remodeling. In the sclerotic type, growth arrest is a less probable mechanism. Necrosis within the tumour and/or local changes in hormonal control, plus remodelling of the sclerotic area takes longer. Knowledge of the potential for spontaneous resolution may help in management of these tumour and tumour-like lesions of bone. Yanagawa, T. et al. (2001)

  9. Low volume fraction rimming flow in a rotating horizontal cylinder

    Chen, Po-Ju; Tsai, Yu-Te; Liu, Ta-Jo; Wu, Ping-Yao

    2007-12-01

    An experimental study was carried out to examine how uniform rimming flow is established for a very small volume fraction of aqueous Newtonian solutions in a partially filled rotating horizontal cylinder. There exists a certain critical volume fraction (Vc) for each solution, where the rotational speed required to achieve uniform rimming flow takes a minimum value. Counterintuitively, it takes greater rotation speeds for both larger and smaller volume fractions than this. Axial instabilities are observed for liquid volume fractions above or below this critical value. For V >Vc the defects are mainly of shark-teeth and turbulent types, while for V speed for V >Vc, but has very little effect for V speed Ω to achieve rimming flow is presented as a function of the dimensionless liquid volume fraction ϕ. The competing effects of fluid inertia and viscous force on rimming flow are demonstrated from a dimensionless plot of Ω versus ϕ.

  10. A STUDY OF HAEMOGLOBIN PATTERNS AMONG THE STUDENTS OF RIMS

    Urmila; Sunita,; Mohen Singh; Durlav Chandra

    2015-01-01

    Haemoglobinopathies are a major health problem worldwide. Because of the high prevalence of these disorders in India and especially in North–East, we undertook this limited student based study as RIMS comprised students from the seven North-East states of Arunachal Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Sikkim and Tripura. AIMS: To study the prevalence of haemoglobin variants among the North-East students of RIMS and to find out any abnormal haemoglobin pattern pertai...

  11. Rim instability in dewetting of thin polymer films

    Marquant, Ludovic

    2013-01-01

    Understanding flow properties at the solid/liquid interface is important for numerous of technological applications in nanotechnology and microfluidic. The strong scientific interest in the field of thin liquid films led to new conclusions on the impact of hydrodynamic slippage on the dewetting dynamics and on the shape of the rim growing at the three phase contact line. This work consists of verifying the validity of these findings at late stage of dewetting, i.e. while the rim instabilit...

  12. CT rim effects in various head and neck lesions

    The authors evaluated various head and neck lesions seen from April 1988 through March 1990 both by plain and enhanced CT, examined the incidence of rim effect (or rim enhancement), classified these effects, and discussed underlying mechanisms. The subjects were 177 patients with primary tumors (28 benign and 49 malignant tumors), lymphadenopathy associated with malignancy (9), inflammatory lesions (20), cystic lesions (12), other lesions (7), and 22 without abnormal findings. Among these 177, rim effects were observed in 22 cases (12%). These effects were analyzed and classified. The incidences of rim effect according lesion type are as follows; cervical lymphadenopathy associated with malignancy 5/9 (56%), primary tumors 8/77 (10%), inflammatory lesions none, cystic lesions 7/12 (58%), and others 3/7 (43%). The highest incidence was seen with cystic lesions including mucoceles of the paranasal sinuses and cervical cysts. Rim effects were classified as follows; Type 1: cystic pattern, Type 2: parenchymatous pattern, Type 3: vascular pattern and Type 4: others. Type 1 was seen in 15 cases (68%), Type 2 in 3 cases (14%), Type 3 in 3 cases (14%), and Type 4 in 1 case (5%). Type 1 included 6 cystic lesions, 3 malignant lymphadenopathies, 3 benign tumors and others. Type 2 included 2 malignant lymphadenopathies and 1 benign tumor, and Type 3, 2 jugular thromboses and 1 carotid atheroma. There was only one Type 4, a cystic lesion. Of interest is the mode of incidences among cervical lymphadenopathies associated with malignancy. Accessory chains showed rim effects in 3/7, all Type 1, and jugular chains in 2/13, all Type 2. The mechanism underlying the rim effects was discussed and the vascularity of the peripheral rims of the lesions appeared to be the most important factor in addition to technical artifacts inherent in CT. (author)

  13. Bone scintigraphy, radiography and MRI in the diagnosis and evaluation of treatment response of calcaneal tuberculosis

    Aim: We describe the role of various imaging modalities in the diagnosis and follow up of calcaneal tuberculosis. Materials and methods: Six patients (5 males, 1 female; age range 16-49 years) presented with heel pain. All patients underwent routine laboratory and radiological investigations e.g. radiographs, MRI and skeletal scintigraphy as part of initial diagnostic work-up. In all patients the diagnosis of tuberculosis was confirmed based on histopathology or culture. Standard multi-drug anti-tubercular therapy (ATT) was administered for 15 months. All patients were subsequently followed up with clinical evaluation, laboratory investigations and imaging. Skeletal scintigraphy, MRI and radiographs were repeated at 12 to 15 months from the initiation of anti-tubercular treatment in all patients. Results: Five out of six patients had lytic lesions at presentation on radiographs. Four of these 5 patients also had surrounding sclerosis. Follow-up radiographs obtained 12-15 months after starting ATT, showed an increase in surrounding sclerosis with progressive reduction in area of osteopenia in four and mild sclerotic changes in one. In the remaining one patient radiograph were normal both at presentation and follow up. Three phase bone scintigraphy revealed increased blood flow and blood pool activity and 'hot spots' in 5 and a central photopenic area in the calcaneum in one patient at the time of diagnosis. After starting ATT, significant reduction in vascularity and reactive bone changes in 5 patients and mild improvement in one patient. MRI was done in three patients, which revealed hyperintense lesion with erosion of the superior articular surface in 2 and 'Bull's eye' lesion with a hypointense centre and a surrounding hyperintense rim on post contrast T1W images in one patient. Follow-up MRI showed intermediate signal intensity on T2 weighted images that corresponded to caseous necrosis and high signal intensity related to granulomas or effusion. Conclusion

  14. Southern rim of Isidis Planitia basin

    2002-01-01

    (Released 11 April 2002) The Science This image, crossing the southern rim of the Isidis Planitia basin, displays the contrasting morphologies of the relatively rough highland terrain (in the lower portion of the image) and the relatively smooth materials of the basin (at top). Upon closer viewing, the basin materials display an extensive record of cratering, including a small cluster of craters just north and west of the two prominent craters in the upper part of the image. This cluster of craters may represent what are called 'secondary' craters, which are craters that form as a result of the ejection of debris from a nearby impact. Alternatively, these craters may have formed simultaneously by the impact of many pieces of a larger meteoroid that broke up upon entry into Mars' atmosphere. The large craters in the image are approximately 800 meters (875 yards) in diameter. Also visible in the image are dark streaks on the east-facing side of the north-south trending ridge. These streaks are likely the result of debris movement down slope. A dark patch of material is visible at the left of the image; dark materials are typically mobile sands, and linear dune forms are apparent within the dark patch. The Story Battered and beaten up, the surface of Mars reads like a history book to geologists, who want to study what has happened to the red planet over its geological history. Look for two larger craters diagonal from one another in the northern part of this image, and then for the smattering of tinier craters near them. How did these smaller craters come to be? Did a large meteoroid streak in through the Martian atmosphere and get broken up as it passed through, pummeling Mars moments later with its smaller, scattered pieces? Or were rocks and dirt blasted off the surface when the two larger craters were formed, only to rain down again on Mars shortly afterwards? No one quite knows for sure.... Another enigmatic-looking feature is near the left center of this image

  15. Rim region growth and its composition in reaction bonded boron carbide composites with core-rim structure

    Aluminum was detected in reaction-bonded boron carbide that had been prepared by pressureless infiltration of boron carbide preforms with molten silicon in a graphite furnace under vacuum. The presence of Al2O3 in the heated zone, even though not in contact with the boron carbide preform, stands behind the presence of aluminium in the rim region that interconnects the initial boron carbide particles. The composition of the rim corresponds to the Bx(C,Si,Al)y quaternary carbide phase. The reaction of alumina with graphite and the formation of a gaseous aluminum suboxide (Al2O) accounts for the transfer of aluminum in the melt and, subsequently in the rim regions. The presence of Al increases the solubility of boron in liquid silicon, but with increasing aluminum content the activity of boron decreases. These features dominate the structural evolution of the rim-core in the presence of aluminum in the melt.

  16. Rim region growth and its composition in reaction bonded boron carbide composites with core-rim structure

    Hayun, S.; Weizmann, A.; Dilman, H.; Dariel, M. P.; Frage, N.

    2009-06-01

    Aluminum was detected in reaction-bonded boron carbide that had been prepared by pressureless infiltration of boron carbide preforms with molten silicon in a graphite furnace under vacuum. The presence of Al2O3 in the heated zone, even though not in contact with the boron carbide preform, stands behind the presence of aluminium in the rim region that interconnects the initial boron carbide particles. The composition of the rim corresponds to the Bx(C,Si,Al)y quaternary carbide phase. The reaction of alumina with graphite and the formation of a gaseous aluminum suboxide (Al2O) accounts for the transfer of aluminum in the melt and, subsequently in the rim regions. The presence of Al increases the solubility of boron in liquid silicon, but with increasing aluminum content the activity of boron decreases. These features dominate the structural evolution of the rim-core in the presence of aluminum in the melt.

  17. Intraosseous lipoma of the iliac: case report☆

    de Moraes, Frederico Barra; Paranahyba, Rodrigo Marques; do Amaral, Rogério Andrade; Bonfim, Vinícius Mendes; Jordão, Nathalya Ducarmo; Souza, Raimundo Djalma

    2016-01-01

    Lipomas are benign tumors that attack fat cells and most often affecting soft tissues in adulthood. On rare occasions, they may affect bones, preferentially the metaphyses of the long bone. They are generally asymptomatic and radiography shows radiolucent lesions with a thin sclerotic rim or radiodense lesions with a thick sclerotic rim. Malignant transformation of these tumors is rare, as is their recurrence, and there is no need for surgery in most cases. In this report, we present a rare case of intraosseous lipoma in the iliac bone. PMID:26962507

  18. Hand rim configuration : effects on physical strain and technique in unimpaired subjects?

    van der Woude, L H V; Formanoy, M; de Groot, S

    2003-01-01

    OBJECTIVE: Hand rim wheelchair propulsion is inefficient and physically straining. To evaluate the possibly advantageous role in this respect of three different prototype hand rim configurations (a rubber foam-coated cylindrical (II) hand rim and two profiled rubber foam-coated hand rims (wide and n

  19. A simplified procedure for preparation of undecalcified human bone sections

    Wallin, J A; Tkocz, I; Levinsen, J

    1985-01-01

    A new type of apparatus for sectioning samples of hard, undecalcified bone is described. Slices of fresh or archeological human bone 4-5 mm thick are dehydrated and then embedded in epoxy resin. The apparatus used to prepare sections from the resulting blocks consists of a low-speed rim-type diam...

  20. Bone tumor

    Tumor - bone; Bone cancer; Primary bone tumor; Secondary bone tumor ... The cause of bone tumors is unknown. They often occur in areas of the bone that grow rapidly. Possible causes include: Genetic defects ...

  1. Bone Grafts

    A bone graft transplants bone tissue. Surgeons use bone grafts to repair and rebuild diseased bones in your hips, knees, spine, and sometimes other bones and joints. Grafts can also repair bone loss caused by some ...

  2. Aqueous Alteration of Endeavour Crater Rim Apron Rocks

    Ming, D. W.; Mittlefehldt, D. W.; Gellert, R.; Clark, B. C.; Morris, R. V.; Yen, A. S.; Arvidson, R. E.; Crumpler, L. S.; Farrand, W. H.; Grant, J. A., III; Jolliff, B. L.; Parker, T. J.; Peretyazhko, T.

    2014-12-01

    Mars Exploration Rover Opportunity is exploring Noachian age rocks of the rim of 22 km diameter Endeavour crater. Overlying the pre-impact lithologies and rim breccias is a thin apron of fine-grained sediments, the Grasberg fm, forming annuli on the lower slopes of rim segments. Hesperian Burns fm sandstones overly the Grasberg fm. Grasberg rocks have major element compositions that are distinct from Burns fm sandstones, especially when comparing interior compositions exposed by the Rock Abrasion Tool. Grasberg rocks are also different from Endeavour rim breccias, but have general compositional similarities to them. Grasberg sediments are plausibly fine-grained materials derived from the impact breccias. Veins of CaSO4 transect Grasberg fm rocks demonstrating post-formation aqueous alteration. Minor/trace elements show variations consistent with mobilization by aqueous fluids. Grasberg fm rocks have low Mn and high Fe/Mn ratios compared to the other lithologies. Manganese likely was mobilized and removed from the Grasberg host rock by redox reactions. We posit that Fe2+ from acidic solutions associated with formation of the Burns sulfate-rich sandstones acted as an electron donor to reduce more oxidized Mn to Mn2+. The Fe contents of Grasberg rocks are slightly higher than in other rocks suggesting precipitation of Fe phases in Grasberg materials. Pancam spectra show that Grasberg rocks have a higher fraction of ferric oxide minerals than other Endeavour rim rocks. Solutions transported Mn2+ into the Endeavour rim materials and oxidized and/or precipitated it in them. Grasberg has higher contents of the mobile elements K, Zn, Cl, and Br compared to the rim materials. Similar enrichments of mobile elements were measured by the Spirit APXS on West Spur and around Home Plate in Gusev crater. Enhancements in these elements are attributed to interactions of hydrothermal acidic fluids with the host rocks. Interactions of fluids with the Grasberg fm postdate the genesis

  3. Regional carrying capacity: case studies of Bohai Rim area

    2002-01-01

    Carrying capacity research has been carried out for a long time. However, synthesized carrying capacity researches based on systematic views began only in the 1970s. There is even less work done in China. This paper tries to address both synthesized carrying capacity research and its utilization in China. State spaces method from the systematic science was borrowed to construct the conceptual model of regional carrying capacity. Based on the conceptual model and the surveys in the Bohai Rim area, we construct a representative indicators system for quantifying regional carrying capacity in the Bohai Rim. While employing system dynamic models we simulated the evolving trend of both the regional carrying states and regional carrying capacity from 1999 to 2015. The results proved the statement that Bohai Rim is overall over-capacity for a long time and will be over-capacity in the foreseeable future. Among all the restriction factors, water shortage and environmental pollution stand out to be the two primary obstacles for Bohai Rim's sustainable development.Regional differentiation analysis further indicates that coastal areas of the Bohai Rim burden more than its overall level. However, Shandong province shows some good signs in addressing the regional carrying capacity issues. The research is successful in addressing the quantification of regional carrying capacity issues, but nonetheless it needs further refinery and more information.

  4. Effect of Er,Cr:YSGG Laser at Different Output Powers on the Micromorphology and the Bond Property of Non-Carious Sclerotic Dentin to Resin Composites.

    Xiang Sun

    Full Text Available The objective of this study was to investigate the influence of Er,Cr:YSGG laser irradiated at different powers on the micromorphology and the bonding property of non-carious sclerotic dentin to resin composites.Two hundred bovine incisors characterized by non-carious sclerotic dentin were selected, and the seventy-two teeth of which for surface morphological analysis were divided into nine groups according to various treatments (A: the control group, B: only treated with the adhesive Adper Easy One, C: diamond bur polishing followed by Adper Easy One, D-I: Er,Cr:YSGG laser irradiating at 1W, 2W, 3W, 4W, 5W, 6W output power, respectively, followed by Adper Easy One. The surface roughness values were measured by the non-contact three-dimensional morphology scanner, then the surface micromorphologies of surfaces in all groups were assessed by scanning electron microscopy (SEM; meanwhile, Image Pro-Plus 6.0 software was used to measure the relative percentage of open tubules on SEM images. The rest, one hundred twenty-eight teeth for bond strength test, were divided into eight groups according to the different treatments (A: only treated with the adhesive Adper Easy One, B: diamond bur polishing followed by the above adhesive, C-H: Er,Cr:YSGG laser irradiating at 1 W, 2 W, 3 W, 4 W, 5 W, 6 W output power, respectively, followed by the above adhesive, and each group was subsequently divided into two subgroups according to whether aging is performed (immediately tested and after thermocycling. Micro-shear bond strength test was used to evaluate the bond strength.The 4W laser group showed the highest roughness value (30.84±1.93μm, which was statistically higher than the control group and the diamond bur groups (p<0.05. The mean percentages ((27.8±1.8%, (28.0±2.2%, (30.0±1.9% of open tubules area in the 4W, 5W, 6W group were higher than other groups (p<0.05. The 4W laser group showed the highest micro-shear bond strength not only in immediately

  5. Effect of Er,Cr:YSGG Laser at Different Output Powers on the Micromorphology and the Bond Property of Non-Carious Sclerotic Dentin to Resin Composites

    Wang, Weiguo; Jiao, Yang; Wang, Wanshan; Yang, Yanwei; Wei, Jingjing; Shen, Lijuan; Chen, Jihua

    2015-01-01

    Background The objective of this study was to investigate the influence of Er,Cr:YSGG laser irradiated at different powers on the micromorphology and the bonding property of non-carious sclerotic dentin to resin composites. Methods Two hundred bovine incisors characterized by non-carious sclerotic dentin were selected, and the seventy-two teeth of which for surface morphological analysis were divided into nine groups according to various treatments (A: the control group, B: only treated with the adhesive Adper Easy One, C: diamond bur polishing followed by Adper Easy One, D-I: Er,Cr:YSGG laser irradiating at 1W, 2W, 3W, 4W, 5W, 6W output power, respectively, followed by Adper Easy One). The surface roughness values were measured by the non-contact three-dimensional morphology scanner, then the surface micromorphologies of surfaces in all groups were assessed by scanning electron microscopy (SEM); meanwhile, Image Pro-Plus 6.0 software was used to measure the relative percentage of open tubules on SEM images. The rest, one hundred twenty-eight teeth for bond strength test, were divided into eight groups according to the different treatments (A: only treated with the adhesive Adper Easy One, B: diamond bur polishing followed by the above adhesive, C-H: Er,Cr:YSGG laser irradiating at 1 W, 2 W, 3 W, 4 W, 5 W, 6 W output power, respectively, followed by the above adhesive), and each group was subsequently divided into two subgroups according to whether aging is performed (immediately tested and after thermocycling). Micro-shear bond strength test was used to evaluate the bond strength. Results The 4W laser group showed the highest roughness value (30.84±1.93μm), which was statistically higher than the control group and the diamond bur groups (plaser group showed the highest micro-shear bond strength not only in immediately tested (17.60±2.55 PMa) but after thermocycling (14.35±2.08MPa). Conclusion The Er,Cr:YSGG laser at 4W power can effectively improve the bonding

  6. Observations of neutral carbon in the NGC 1977 bright rim

    Wootten, A.; Phillips, T. G.; Beichman, C. A.; Frerking, M.

    1982-01-01

    Strong neutral carbon emission at 610 microns (492 GHz) has been detected from a bright-rimmed cloud abutting the H II region NGC 1977. The similarity of velocity and width between (C-13)O and C I lines suggests that both lines originate in the same region. A model for the density and temperature structure of the cloud, based on (C-13)O and (C-12)O observations, has been used to estimate the carbon abundance. The abundances of both C I and (C-13)O increase with depth into the cloud away from the rim. The carbon abundance reaches its peak value nearer the rim than does the (C-13)O abundance. This variation in the relative abundance distributions of CO and C I confirms the importance of photodissociation in the chemistry of molecular clouds, and of the C I line to studies of the interaction of hot stars with clouds.

  7. Analytical capabilities of RIMS: absolute sensitivity and isotopic analysis

    Resonance ionization mass spectrometry (RIMS) with thermal filament sources is becoming an established analytical technique. The results of recent isotope ratio measurements carried out on small (60 - 200ng) lutetium samples are presented. The sensitivity and selectivity of continuous wave (CW) laser RIMS allow the accurate determination of very large ratios (approx. 106) in real samples containing numerous isobaric interferences. In addition, high resolution optical spectra of lutetium isotopes have been generated using RIMS as a prelude to isotopically selective resonance ionization. Also, the results of two-color spectroscopic studies for isotope ratio measurements in technetium are presented. A large number of multiply-resonant sequences have been explored; however, the presence of Tc molecular species appears to limit the potential sensitivity of the measurement. (author)

  8. Pacific Rim coal trade model for U.S. involvement

    The world contains 700 billion tons of coal reserves mineable by today's technical standards with the United States having one-third of the total. Coal demand of the Pacific Rim will grow very rapidly in the next decade due to expanded use of coal to produce electricity and steel. Imported 1989 coal supply to the Pacific Rim was from Australia (50%), Canada (18%), U.S. (13%), South Africa (7%), U.S.S.R. (6%), China (4%) and Indonesia (1%). The U.S. coal price will continue to trend downward due to increasing mine productivity. The world is moving toward a transnational economy. Groups of nations are forming economic ties and cooperation. This paper reports that the U.S. can increase involvement in the Pacific Rim coal markets by offering value-added coal sales transactions and by understanding Orient culture

  9. Performance of Non-Cemented, Hemispherical, Rim-Fit, Hydroxyapatite Coated Acetabular Component.

    John, Thomas K; Ghosh, Gaurav; Ranawat, Chitranjan S; Ranawat, Amar S; Meftah, Morteza

    2015-12-01

    The purpose of this study was to assess the durability of a non-cemented, hemispherical rim-fit, hydroxyapatite coated cup with a highly cross-linked polyethylene in 223 total hip arthroplasties. At 6-years follow-up (range, 5-9), there were no cup revisions for osteolysis or loosening. Radiologic evidence of osseointegration was based on presence of Stress Induced Reactive Cancellous Bone and radial trabeculae, seen in 47% and 93% of cups, respectively; both were most prevalent in Zone 1. There was no interference demarcation in any zones. Two cups were revised (0.9%): one for dislocation and another for infection. The Kaplan-Meier survivorship for cup revision for any failure (infection, dislocation) was 99% and for mechanical failure (osteolysis, loosening) was 100%. This design has excellent safety, efficacy and durability. PMID:26235521

  10. Bone Biopsy

    ... Physician Resources Professions Site Index A-Z Bone Biopsy Bone biopsy uses a needle and imaging guidance ... limitations of Bone Biopsy? What is a Bone Biopsy? A bone biopsy is an image-guided procedure ...

  11. Banjo Rim Height and Sound in the Pot

    Politzer, David

    2016-01-01

    Rim and back geometry determine much of the behavior of sound inside the pot, whose effect on total, produced sound is subtle but discernible. The theory of sound inside a cylinder is reviewed and demonstrated. And previous work on the Helmholtz resonance and the interplay between the Helmholtz resonance and the lowest head mode is revisited using some improved techniques.

  12. Asia and the Pacific Rim in the Curriculum.

    Schlene, Vickie J.

    1991-01-01

    Presents a sampling of items from the ERIC database dealing with Asia and the Pacific Rim. Urges the inclusion of these countries in the curriculum as exchange of peoples, goods, and cultures increases. Emphasizes the growing importance of the region as a global force. Includes articles and books on culture, economies, and cultural exchange…

  13. Posterior glenoid rim deficiency in recurrent (atraumatic) posterior shoulder instability

    Objective. To assess the shape of the posterior glenoid rim in patients with recurrent (atraumatic) posterior instability.Design and patients. CT examinations of 15 shoulders with recurrent (atraumatic) posterior instability were reviewed in masked fashion with regard to abnormalities of the glenoid shape, specifically of its posterior rim. The glenoid version was also assessed. The findings were compared with the findings in 15 shoulders with recurrent anterior shoulder instability and 15 shoulders without instability. For all patients, surgical correlation was available.Results. Fourteen of the 15 (93%) shoulders with recurrent (atraumatic) posterior shoulder instability had a deficiency of the posteroinferior glenoid rim. In patients with recurrent anterior instability or stable shoulders such deficiencies were less common (60% and 73%, respectively). The craniocaudal length of the deficiencies was largest in patients with posterior instability. When a posteroinferior deficiency with a craniocaudal length of 12 mm or more was defined as abnormal, sensitivity and specificity for diagnosing recurrent (atraumatic) posterior instability were 86.7% and 83.3%, respectively. There was a statistically significant difference in glenoid version between shoulders with posterior instability and stable shoulders (P=0.01).Conclusion. Recurrent (atraumatic) posterior shoulder instability should be considered in patients with a bony deficiency of the posteroinferior glenoid rim with a craniocaudal length of more than 12 mm. (orig.)

  14. Rim region growth and its composition in reaction bonded boron carbide composites with core-rim structure

    Hayun, S; Weizmann, A; Dilman, H; Dariel, M P; Frage, N [Department of Materials Engineering, Ben-Gurion University of the Negev, P. O. Box 653, Beer-Sheva 84105 (Israel)], E-mail: hayuns@bgu.ac.il

    2009-06-01

    Aluminum was detected in reaction-bonded boron carbide that had been prepared by pressureless infiltration of boron carbide preforms with molten silicon in a graphite furnace under vacuum. The presence of Al{sub 2}O{sub 3} in the heated zone, even though not in contact with the boron carbide preform, stands behind the presence of aluminium in the rim region that interconnects the initial boron carbide particles. The composition of the rim corresponds to the B{sub x}(C,Si,Al){sub y} quaternary carbide phase. The reaction of alumina with graphite and the formation of a gaseous aluminum suboxide (Al{sub 2}O) accounts for the transfer of aluminum in the melt and, subsequently in the rim regions. The presence of Al increases the solubility of boron in liquid silicon, but with increasing aluminum content the activity of boron decreases. These features dominate the structural evolution of the rim-core in the presence of aluminum in the melt.

  15. Factors influencing diagnostic yield of CT-guided percutaneous core needle biopsy for bone lesions

    Aim: To evaluate the factors influencing diagnostic yield of computed tomography (CT)-guided percutaneous core needle biopsy (CNB) for bone lesions. Materials and methods: Between September 2005 and July 2011, 162 consecutive CT-guided CNB procedures were performed in 155 patients. The variables analysed were age, sex, lesion location, lesion type, lesion size, specimen size, biopsy needle gauge, and individual radiologist. The factors influencing diagnostic yield of CT-guided percutaneous CNB for bone lesions were determined by multivariate analysis of variables. Results: The diagnostic yield was 81.5%. Diagnostic yield was 89.9% for lytic bone lesions and 48.5% for sclerotic bone lesions (p < 0.001), and 89.2% for lesions ≥3 cm and 73.4% for lesions <3 cm (p = 0.010). The significant factors influencing diagnostic yield of CT-guided percutaneous CNB for bone lesions were lesion type [p < 0.001; odds ratio (OR) for a lytic lesion was approximately 12 times higher than that for a sclerotic lesion; 95% confidence interval (CI): 4.22–34.01], and lesion size (p = 0.012; OR for a lesion size ≥3 cm was about five-times higher than that for a lesion size <3 cm; 95% CI: 1.42–16.71). Conclusion: Lesion type and lesion size are determining factors in diagnostic yield. The higher diagnostic yield is correlated with lytic lesion and lesion size ≥3 cm

  16. A radiographic investigation of third carpal bone injury in 42 racing thoroughbreds

    A retrospective study of carpal radiographs from 42 racing thoroughbreds with carpal lameness was performed. Radiographs from 50 carpal examinations were available for review. The radiographic findings pertaining to the third carpal bone were described. Fractures and/or sclerosis occurred almost exclusively within the radial fossa. The occurrence of sclerosis without fracture in 20 of the 50 carpal examinations was higher than anticipated, occurring in both the right and left third carpal bone with equal frequency. The right third carpal bone was more frequently fractured and more severely affected than the left. The sclerotic changes seen in the radial fossa of the third carpal bone may be stress-induced, possibly preceding more serious changes in the joint such as cartilage damage or gross fracture. Earlier recognition of sclerosis of the third carpal bone may help prevent more serious changes from occurring

  17. 18F-FDG PET/CT bone/bone marrow findings in Hodgkin's lymphoma may circumvent the use of bone marrow trephine biopsy at diagnosis staging

    Accurate staging of Hodgkin's lymphoma (HL) is necessary in selecting appropriate treatment. Bone marrow trephine biopsy (BMB) is the standard procedure for depicting bone marrow involvement. BMB is invasive and explores a limited part of the bone marrow. 18F-FDG PET/CT is now widely used for assessing response to therapy in HL and a baseline study is obtained to improve accuracy. The aim of this retrospective analysis was to assess whether routine BMB remains necessary with concomitant 18F-FDG PET/CT. Data from 83 patients (newly diagnosed HL) were reviewed. All patients had received contrast-enhanced CT, BMB and 18F-FDG PET/CT. Results of BMB were not available at the time of 18F-FDG PET/CT imaging. Seven patients had lymphomatous involvement on BMB. Four patients had bone involvement on conventional CT (two with negative BMB). All patients with bone marrow and/or bone lesions at conventional staging were also diagnosed on 18F-FDG PET/CT scan. PET/CT depicted FDG-avid bone/bone marrow foci in nine additional patients. Four of them had only one or two foci, while the other had multiple foci. However, the iliac crest, site of the BMB, was not involved on 18F-FDG PET/CT. Osteolytic/sclerotic lesions matching FDG-avid foci were visible on the CT part of PET/CT in three patients. MRI ordered in three other patients suggested bone marrow involvement. Interim and/or end-therapy 18F-FDG PET/CT documented response of FDG-avid bone/bone marrow foci to chemotherapy in every patient. 18F-FDG PET/CT highly improves sensitivity for diagnosis of bone/bone marrow lesions in HL compared to conventional staging. (orig.)

  18. The Rim Trail at Pipe Spring National Monument, Arizona (pisp_trail)

    National Park Service, Department of the Interior — This is an Arc/Info coverage consisting of 4 arcs representing The Rim Trail at Pipe Spring National Monument, Arizona. The Rim Trail was collected by a Trimble...

  19. Interesting bone scans - unusual findings

    Dobson, M.; Wadhwa, S.S.; Mansberg, R.; Fernandes, V.B. [Wollongong Hospital, Wollongong, NSW (Australia)

    1997-12-01

    A 59-year-old female with carcinoma of the colon and known liver metastatic disease was referred for bone scan to evaluate for bone metastases. Although no bone metastases were found, there was abnormal uptake noted in the liver corresponding to a metastatic calcified lesion. The only other findings were of degenerative disease in the cervical spine, right shoulder and small joints of the hands. A 69-year-old male with carcinoma of the prostate and right side low back pain was referred for bone scan. No focal abnormalities to suggest metastatic disease were identified; findings within the cervical spine, lumber spine and knees were presumed secondary to degenerative disease. Intermittent pain persisted and the patient was referred for a repeat bone scan six months later. Previous scan findings of degenerative disease and no metastatic disease were confirmed; however, closer inspection revealed an enlarged right kidney with significant retention of tracer in the pelvicalyceal system suggesting possible obstruction. A Retrograde pyelogram was performed, and no obvious obstruction demonstrated. As bone scan findings were very suggestive of obstruction, a DTPA scan with lasix was performed showing a dilated right collecting system with no functional obstruction. Given the degree of dilation, it is possible that the patient experiences intermittent PUJ obstruction causing his symptoms. A 33-year-old male with insulin dependent diabetes mellitus and viral arthritis was referred for a bone scan. A three phase revealed increased uptake in the region of the knee and leR proximal tibia. Delayed whole body images revealed multiple focal areas of osteoblastic activity in the leR tibia. Abnormal uptake was also seen in the upper third of the leR femur. The remainder of the skeletal survey was normal. X-ray correlation of the leR tibia and femoral findings was undertaken. Combinating unilateral changes on bone scan and X-ray although very suggestive of sclerotic polyostotic

  20. Interesting bone scans - unusual findings

    A 59-year-old female with carcinoma of the colon and known liver metastatic disease was referred for bone scan to evaluate for bone metastases. Although no bone metastases were found, there was abnormal uptake noted in the liver corresponding to a metastatic calcified lesion. The only other findings were of degenerative disease in the cervical spine, right shoulder and small joints of the hands. A 69-year-old male with carcinoma of the prostate and right side low back pain was referred for bone scan. No focal abnormalities to suggest metastatic disease were identified; findings within the cervical spine, lumber spine and knees were presumed secondary to degenerative disease. Intermittent pain persisted and the patient was referred for a repeat bone scan six months later. Previous scan findings of degenerative disease and no metastatic disease were confirmed; however, closer inspection revealed an enlarged right kidney with significant retention of tracer in the pelvicalyceal system suggesting possible obstruction. A Retrograde pyelogram was performed, and no obvious obstruction demonstrated. As bone scan findings were very suggestive of obstruction, a DTPA scan with lasix was performed showing a dilated right collecting system with no functional obstruction. Given the degree of dilation, it is possible that the patient experiences intermittent PUJ obstruction causing his symptoms. A 33-year-old male with insulin dependent diabetes mellitus and viral arthritis was referred for a bone scan. A three phase revealed increased uptake in the region of the knee and leR proximal tibia. Delayed whole body images revealed multiple focal areas of osteoblastic activity in the leR tibia. Abnormal uptake was also seen in the upper third of the leR femur. The remainder of the skeletal survey was normal. X-ray correlation of the leR tibia and femoral findings was undertaken. Combinating unilateral changes on bone scan and X-ray although very suggestive of sclerotic polyostotic

  1. CT imaging of bone and bone marrow infiltration in malignant melanoma--Challenges and limitations for clinical staging in comparison to 18FDG-PET/CT.

    Bier, Georg; Hoffmann, Vera; Kloth, Christopher; Othman, Ahmed E; Eigentler, Thomas; Garbe, Claus; La Fougère, Christian; Pfannenberg, Christina; Nikolaou, Konstantin; Klumpp, Bernhard

    2016-04-01

    Rationale of this study was the evaluation of the diagnostic value of computed tomography (CT) in the detection of bone marrow infiltration in comparison to PET/CT. Fifty patients (age 61 ± 15.12 years) with metastatic malignant melanoma underwent 18F-FDG-PET/CT, including contrast-enhanced CT. 2 readers evaluated the CT images in consensus for bone and bone marrow lesions focusing on lesion location, type and size. PET/CT was used as reference standard to estimate sensitivity, specificity, negative and positive predictive value. Moreover, the bone marrow density was estimated in the long bones and the sacral bone. Serum hamoglobin, thrombocyte level and S100 protein were correlated with the presence or absence of bone and bone marrow lesions. According to PET/CT as standard of reference, of 594 bone and medullary lesions 495 were considered malignant. Of these 77.8% were medullary, 20.4% lytic, 1% sclerotic and 0.8% mixed lytic/sclerotic. Contrast-enhanced CT yielded a lesion-based sensitivity of 36.8% and a specificity of 87.9% (PPV 93.8%; NPV 21.8%). Patient-based sensitivity and specificity were 78.8% and 82.4%, respectively. Of the missed lesions, most were medullary (95.8%). A disseminated bone marrow involvement (defined as >10 bone marrow lesions or diffuse infiltration of a whole body segment) was described in 11 cases, in 6 cases the disseminated involvement was underestimated or missed on CT. In cases with disseminated bone marrow involvement the bone marrow density was significantly higher in the humerus (p=0.04), but not in the femur or sacral bone (p=0.06). Multivariate analysis revealed no isolated effect of bone metastases on S100 serum and hemoglobin level, but both were significantly altered in patients with disseminated bone marrow involvement (p<0.05). In conclusion, the diagnostic value of computed tomography for the detection of bone marrow metastases in patients with melanoma, is limited. Especially in cases with disseminated bone marrow

  2. Stability Analysis of Non-Newtonian Rimming Flow

    Fomin, Sergei; Haine, Peter

    2015-01-01

    The rimming flow of a viscoelastic thin film inside a rotating horizontal cylinder is studied theoretically. Attention is given to the onset of non-Newtonian free-surface instability in creeping flow. This non-inertial instability has been observed in experiments, but current theoretical models of Newtonian fluids can neither describe its origin nor explain its onset. This study examines two models of non Newtonian fluids to see if the experimentally observed instability can be predicted analytically. The non-Newtonian viscosity and elastic properties of the fluid are described by the Generalized Newtonian Fluid (GNF) and Second Order Viscoelastic Fluid (SOVF) constitutive models, respectively. With linear stability analysis, it is found that, analogously to the Newtonian fluid, rimming flow of viscous non-Newtonian fluids (modeled by GNF) is neutrally stable. However, the viscoelastic properties of the fluid (modeled by SOVF) are found to contribute to the flow destabilization. The instability is shown to in...

  3. rimäärittely katsojakokemuksen vahvistajana elokuvassa

    Köteleki, Sabina

    2015-01-01

    Kirjallisessa opinnäytetyössäni käsitellään elokuvien värien käyttöä ja värimäärittelyä katsojakokemuksen vahvistajana. Sen tarkoituksena on osoittaa, että tarkasti mietityllä ja luovasti toteutetulla värimäärittelyllä pystytään ratkaisevasti vaikuttamaan katsojan tulkintaan ja parantamaan sitä. Katsojan ei tarvitse olla värien symboliikkaan tai jälkituotantotekniikoihin perehtynyt ihminen ymmärtääkseen elokuvien värien narratiivista voimaa, sillä ihmiset reagoivat väreihin täysin vaistonvara...

  4. Load carrying capacity analysis of materials for aluminium rims

    Fajdiga, Matija; Čižman, Jure

    2015-01-01

    In this contribution we present an experimental simulation of the fatique strength of clamped aluminium rims. This is supported by numerical modelling using the Finite Element Method (FEM), which was used for stress-strain analysis of a model representing a clamped detail during bendings. The design and analysis of the model are made simultaneously on an integrated computer controlled test rig for testing the fatique strength of clamped parts subjected to bending. The simulation is evaluated ...

  5. Donor corneoscleral rim contamination by gentamicin-resistant organisms

    Gopinathan Usha; Agrawal Vinay; Sharma Savitri; Rao Gullapalli

    1994-01-01

    Gentamicin is the most widely used antibiotic in the decontamination of donor cornea for penetrating keratoplasty. However, the incidence of resistance to gentamicin is on the rise. Bacterial isolates from 178 donor corneal rims were studied for gentamicin sensitivity. The overall rate of gentamicin resistance was 63.4%. At 86.2% the Pseudomonas. species had the highest rate of resistance, followed by Streptococci at 84.6%. The high rate of gentamicin resistance encounter...

  6. Radiation Hydrodynamical Models of the Inner Rim in Protoplanetary Disks

    Flock, Mario

    2016-06-01

    Many stars host planets orbiting within one astronomical unit (AU). These close planets’ origins are a mystery that motivates investigating protoplanetary disks’ central regions. A key factor governing the conditions near the star is the silicate sublimation front, which largely determines where the starlight is absorbed, and which is often called the inner rim. We present the first radiation hydrodynamical modeling of the sublimation front in the disks around the young intermediate-mass stars called Herbig Ae stars. The models are axisymmetric, and include starlight heating, silicate grains sublimating and condensing to equilibrium at the local, timedependent temperature and density, and accretion stresses parametrizing the results of MHD magneto-rotational turbulence models. The results compare well with radiation hydrostatic solutions, and prove to be dynamically stable. Passing the model disks into Monte Carlo radiative transfer calculations, we show that the models satisfy observational constraints on the inner rims’s location. A small optically-thin halo of hot dust naturally arises between the inner rim and the star. The inner rim has a substantial radial extent, corresponding to several disk scale heights. While the front’s overall position varies with the stellar luminosity, its radial extent depends on the mass accretion rate. A pressure maximum develops at the position of thermal ionization at temperatures about 1000 K. The pressure maximum is capable of halting solid pebbles’ radial drift and concentrating them in a zone where temperatures are su ciently high for annealing to form crystalline silicates.

  7. Ultrasonic Resonance Spectroscopy of Composite Rims for Flywheel Rotors

    Harmon, Laura M.; Baaklini, George Y.

    2002-01-01

    Flywheel energy storage devices comprising multilayered composite rotor systems are being studied extensively for utilization in the International Space Station. These composite material systems were investigated with a recently developed ultrasonic resonance spectroscopy technique. The ultrasonic system employs a continuous swept-sine waveform and performs a fast Fourier transform (FFT) on the frequency response spectrum. In addition, the system is capable of equalizing the amount of energy at each frequency. Equalization of the frequency spectrum, along with interpretation of the second FFT, aids in the evaluation of the fundamental frequency. The frequency responses from multilayered material samples, with and without known defects, were analyzed to assess the capabilities and limitations of this nondestructive evaluation technique for material characterization and defect detection. Amplitude and frequency changes were studied from ultrasonic responses of thick composite rings and a multiring composite rim. A composite ring varying in thickness was evaluated to investigate the full thickness resonance. The frequency response characteristics from naturally occurring voids in a composite ring were investigated. Ultrasonic responses were compared from regions with and without machined voids in a composite ring and a multiring composite rim. Finally, ultrasonic responses from the multiring composite rim were compared before and after proof spin testing to 63,000 rpm.

  8. Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis

    V Silva

    2007-01-01

    Full Text Available Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Quinck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones.A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, diagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

  9. Bone Grafts

    ... repair and rebuild diseased bones in your hips, knees, spine, and sometimes other bones and joints. Grafts can also repair bone loss caused by some types of fractures or cancers. Once your body accepts the bone ...

  10. Hydrogeology associated to faulting of the Chicxulub Impact Crater rim

    Rebolledo-Vieyra, M.; Hernandez-Terrones, L.; Almazan-Becerril, A.; Valadez-Cruz, F.

    2011-12-01

    The only surface expression of the Chicxulub Impact Crater is a Ring of Cenotes (sinkholes) whose density varies from several cenotes per kilometer, to several kilometers between each cenote. This ring has a radius of approximately 90 km and it is centered at Chicxulub Puerto. It is not known today whether the Ring of Cenotes is the surface expression of the transient cavity as some authors have suggested, or whether it is the outer rim of the impact structure. The center of the ring is approximately coincident with the center of the Chicxulub Impact Crater. Reactivation of K/T rim faults had been associated to the formation of the ring of cenotes. However, none of these models project such faults to the Tertiary sedimentary sequence; therefore we can only infer that the cenotes are associated to these faults. Other hypotheses include "post impact subsidence induced by slumping and viscous relaxation in the rim" and "slumping in the rim of the buried crater, differential thickness in the rocks overlying the crater, or solution collapse within porous impact deposits", others suggest duration of subaerial exposure and weathering as a principal reason both for difference in permeability and cenote density inside and outside the Ring. This is consistent with the evolution of surface features reported. While sedimentation occurred in the basin outlined by the Ring, erosion and karst weathering were taking place outside the Ring. The karst features are associated with gravity gradients, which have been interpreted as corresponding to peripheral faults of the buried crater. We conducted geoelectric tomography perpendicular to the ring of cenotes, where we mapped the karstic features in the area and we interpret the high permeability in this area, to be associated to the faults generated by the differential compaction of the sedimentary sequence within the crater. This fault system generates a secondary porosity with high permeability that allows the circulation of water

  11. Electric pulse treatment of rim wheel metal after operation

    L.I.Vakulenko

    2013-02-01

    Full Text Available Introduction. Load increase on the wheel pair ax requires the use of railway wheels with the advanced complex of properties. Except strength properties, the properties of metal resistance to defect nucleation on the wheel thread are of high importance. The above mentioned properties increase is possible by using different technological decisions: alloying and heat strengthening. Purpose. The purpose is an attempt to estimate the softening degree of the wheel thread metal using the electric pulse treatment. Methodology. Electric pulse treatment (ET was carried out on the special plant in the conditions of JSC DS (Nikolayev city. As the property of metal strength the Vickers hardness number is used. The microstructure research was carried out using the light microscope. The material for research is the carbon steel of the rim fragment of railway wheel №181732, withdrawn after operation, containing 0,55%С, 0,74%Mn, 0,33%Si, 0,009%P, 0,01%S, 0,06% Ni, 0,1%Cr, 0,08%Cu. Findings. Exposing the rim fragment to electric pulse treatment (ET, the qualitative changes of internal structure of the wheel rim metal corresponded to the experimentally observed geometrical dimensions change of the specimen, depending on the cycles number. As a result of the treatment the reduction of cold strained metal hardness is observed. It was found out 20 % softening on the wheel thread for the І rim area the, for the ІІ rim area the 8% softening and for the ІІІ 11% softening in relation to the initial state. Originality. As a result of electric pulse treatment, the change of the specimen geometrical dimensions is observed. Depending on the number of cycles it causes softening effect. It is proved that the observed softening value during ET is qualitatively connected with the cold strain level on the rail wheel thread. Practical value. As a result of metal cold work on the wheel thread its resistance to the defect nucleation is being reduced. The resulted data can

  12. Rim formation and fission gas behaviour: some structure remarks

    In high burn-up LWR nuclear fuel an increase of the Xe-mobility is observed in the rim region according to EPMA. This often coincides with an increase of the local porosity and the grain subdivision of the material in regions around the pores. The restructuring does not always imply disappearance of the prior grain boundaries. This seems to occur in a final step. Micro-XRD studies also show a contraction of the fuel lattice in the rim zone, reflecting mainly the release of accumulated stresses during irradiation, via reordering of defects and defect complexes, including sub-grain formation and displacement of Xe traps. The lattice contraction is not measurable when the fraction of restructured areas is low and the prior grain structure still remains. Nevertheless, in such a case, even the Xe signal by EPMA is observed to decrease, anticipating the displacement of Xe inside the grains, probably towards cavities. However, the quantitative proportion of Xe in matrix and pores can not be given by EPMA. This is confirmed by TEM examinations, showing still plenty of gas bubbles inside restructured grains, in spite of the low Xe signal detected by EPMA. An alternative determination therefore appears necessary. The fission gas release (FGR) behaviour of the rim zone seems then to depend basically on the efficiency of gas retention in its porosity. The closed character of these pores and the low percolation probability derived from the high pore to grain size ratio anticipate a low incidence of open porosity. Also, mechanical tests suggest a low pore interconnection probability by microcracking. However, at very high local burn-ups (>150 GWd/tM), too high porosity values are determined compared to the values derived from immersion density and solid swelling, suggesting the potential existence of open channels. Also, abnormally high porosity values by quantitative metallography might arise from grain pullout during sample preparation. Here, a rough estimation of the release

  13. Growth kinetics of forsterite reaction rims at high-pressure

    Nishihara, Yu; Maruyama, Genta; Nishi, Masayuki

    2016-08-01

    Growth kinetics of forsterite (Fo) reaction rims between periclase (Per) and enstatite (En) were studied experimentally at pressure (P) and temperature (T) conditions of 3.0-11.1 GPa and 1473-1873 K, respectively. Pt markers originally placed at the Per-En interface were always observed at the Per-Fo interface, which indicates that Mg and O are the diffusing species in Fo rim growth (Mg-O coupled diffusion). The presence of some En inclusions in Fo grains and the growth rate of the Fo rim suggests that grain boundary diffusion is dominant rather than lattice diffusion. Considering the very fast grain boundary diffusion of O in olivine, the Mg-O coupled grain boundary diffusion in Fo is deduced to be rate-limited by the diffusivity of Mg. Based on an analysis of data collected under dry conditions, the product of the Mg grain boundary diffusion coefficient (Dgb) and the effective grain boundary width (δ) was determined to be δDgb = δDgb,0exp[-(E∗ + PV∗)/RT] with δDgb,0 = 10-9.68 ± 1.51 m3/s, E∗ = 379 ± 44 kJ/mol and V∗ = -1.9 ± 1.4 cm3/mol. Our results, combined with previously reported data on Mg lattice diffusion in Fo, suggest that for Mg, the significance of grain boundary diffusion increases with depth in the Earth's upper mantle, although lattice diffusion is still dominant for typical mantle grain sizes of 1-10 mm.

  14. A STUDY OF HAEMOGLOBIN PATTERNS AMONG THE STUDENTS OF RIMS

    Urmila

    2015-11-01

    Full Text Available Haemoglobinopathies are a major health problem worldwide. Because of the high prevalence of these disorders in India and especially in North–East, we undertook this limited student based study as RIMS comprised students from the seven North-East states of Arunachal Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Sikkim and Tripura. AIMS: To study the prevalence of haemoglobin variants among the North-East students of RIMS and to find out any abnormal haemoglobin pattern pertaining to a particular community. MATERIAL AND METHODS: The present study was carried out in the Department of Pathology, RIMS. From Sept. 2002 to Dec. 2004, our study included 100 student volunteers taking a minimum of ten from each of the seven states. History of presenting complaints, personal, family and past illness were taken. Physical examination was done with special emphasis on appearance, presence of pallor, jaundice and hepatosplenomegaly etc. Blood samples were collected in 2 EDTA vials, one was used for CBC and another for preparation of hemolysate. CBC was done for all cases by electronic cell counter supported by manual hemocytometry, peripheral blood examination and reticulocyte count. All the cases were routinely screened for haemoglobin type using standard alkaline cellulose acetate electrophoresis with Tris-Ethylene Diamine Tetra Acetic Acid (EDTA borate buffer. Fetal Hb. estimation, sickling test, serum bilirubin estimation were also done in relevant cases. RESULTS: Out of the 100 student volunteers studied, 98 cases showed HbA pattern in 46 males and 52 females while HbE was seen in 2 cases, 1 male and a female. The prevalence of HbE was 2% in our study, which belonged to the ethnic group of Garo of Meghalaya. Both case had mild anemia with microcytosis and normal reticulocyte count. Peripheral smear showed anisopoikilocytosis and target cells. RBC count, MCH values were within normal range. CONCLUSION: Our study showed that HbA was the predominant

  15. Investigation about crack propagation paths in thin rim gears

    F. Curà

    2014-10-01

    Full Text Available Crack propagation in gears is a problem related not only to the life of the components, but also to the concept of failsafe design. Fail safe design means to design a component in order that, if a failure occurs, this may cause a “safe failure”. This aspect is very important above all in aerospace industry. As a matter of fact, in aerospace application, the need of reducing weight brings to produce gears with very thick rim and web. Considering thin rim gears, when a crack is nucleated near the tooth root, it may propagate through the tooth (causing the loss of the entire tooth or a portion of it or the propagation may follow a path across the wheel diameter (causing the projection of big parts of the gear that may break the gearbox and may cause serious damage to the aircraft. The first failure mode is define as “failsafe failure” and the second one as “catastrophic failure” and of course has to be avoided. Designers need to have robust design criteria in order to predict crack propagation paths and to avoid catastrophic failures. In literature, few works are present concerning this topic, in particular related to the effect of geometrical parameters that may affect the crack propagation. In this work a numerical analysis about crack propagation in gears with respect to the backup ratio (ratio between tooth height and rim thickness, initial crack position and shape has been done by means of the Extended FEM (XFEM technique, realizing 3D models. XFEM 3D is a relatively new technique consisting in enriching traditional finite elements with more complex shape functions; in this way it is possible to propagate crack also between mesh nodes and to have mesh independent results. Aim of this paper is to highlight the crack propagation path in order to give to designers an high confident design criterion, related to the gear geometry. In particular, the effect of both rim thickness and orientation of the initial crack have been considered

  16. Amphibole reaction rim textures and mineralogy from the 2006 eruption of Augustine Volcano, Alaska: Nature vs. experiment

    Henton, S.; Larsen, J. F.; Coombs, M. L.

    2011-12-01

    Augustine Volcano forms a small island located in Alaska's Cook Inlet, approximately 180 miles southwest of Anchorage. The 2006 eruption began January 11, 2006, and evolved from an initial phase of explosive activity, through continuous and effusive phases, ending approximately mid-March 2006. We present data on the textural and mineralogical make-up of amphibole reaction rims from 2006 andesites from Augustine. Naturally formed reaction rims are compared to rims formed through decompression and heating experiments. Amphiboles make up less than 1 modal % of most samples. However, variations in composition and texture help to explain pre-and syn-eruptive magma histories. The Augustine 2006 amphiboles contain a mixture of rimmed and unrimmed grains. In order of decreasing abundance (by tally), the dominant phases in reaction rims are orthopyroxene, oxides, plagioclase, and clinopyroxene. Most amphibole reaction rims are between 1- 40 microns in thickness. Thicker rims (> 40 microns) were primarily erupted in the later effusive phase of the eruption. In general, the thickest reactions rims (> 60 microns average thickness) contain coarser individual reaction rim grains (with feret diameters of 15-50 microns). Reaction rims with average thickness of less than 60 microns tend to contain finer reaction rim grains (with feret diameters of 10 microns or less). Some reactions rims show a coarsening of rim grains across the rim, from the amphibole boundary to the glass boundary. Preliminary results show no systematic changes in the aspect ratios of reaction rim grains, either across the rim, or between the different rims. Some rims show a decrease in the An content of plagioclase across the rim, from the amphibole boundary to the glass boundary. Reaction rim textures and mineralogy are complex and suggest that multiple forcing factors (including heating and decompression) were responsible for their formation. This study will compare these natural reaction rims to those formed

  17. Energy Dependence of Synchrotron X-Ray Rims in Tycho's Supernova Remnant

    Tran, Aaron; Petre, Robert; Ressler, Sean M; Reynolds, Stephen P

    2015-01-01

    Several young supernova remnants exhibit thin X-ray bright rims of synchrotron radiation at their forward shocks. Thin rims require strong magnetic field amplification beyond simple shock compression if rim widths are only limited by electron energy losses. But, magnetic field damping behind the shock could produce similarly thin rims with less extreme field amplification. Variation of rim width with energy may thus discriminate between competing influences on rim widths. We measured rim widths around Tycho's supernova remnant in 5 energy bands using an archival 750 ks Chandra observation. Rims narrow with increasing energy and are well described by either loss-limited or damped scenarios, so X-ray rim width-energy dependence does not uniquely specify a model. But, radio counterparts to thin rims are not loss-limited and better reflect magnetic field structure. Joint radio and X-ray modeling favors magnetic damping in Tycho's SNR with damping lengths ~1--5% of remnant radius and magnetic field strengths ~50--...

  18. Optimization of Hydride Rim Formation in Unirradiated Zr 4 Cladding

    Shimskey, Rick W.; Hanson, Brady D.; MacFarlan, Paul J.

    2013-09-30

    The purpose of this work is to build on the results reported in the M2 milestone M2FT 13PN0805051, document number FCRD-USED-2013-000151 (Hanson, 2013). In that work, it was demonstrated that unirradiated samples of zircaloy-4 cladding could be pre-hydrided at temperatures below 400°C in pure hydrogen gas and that the growth of hydrides on the surface could be controlled by changing the surface condition of the samples and form a desired hydride rim on the outside diameter of the cladding. The work performed at Pacific Northwest National Laboratory since the issuing of the M2 milestone has focused its efforts to optimize the formation of a hydride rim on available zircaloy-4 cladding samples by controlling temperature variation and gas flow control during pre-hydriding treatments. Surface conditioning of the outside surface was also examined as a variable. The results of test indicate that much of the variability in the hydride thickness is due to temperature variation occurring in the furnaces as well as how hydrogen gas flows across the sample surface. Efforts to examine other alloys, gas concentrations, and different surface conditioning plan to be pursed in the next FY as more cladding samples become available

  19. Towards the mathematical model of rim structure formation

    Kinoshita, M.

    1997-09-01

    The high burnup LWR UO 2 fuels show a notable micro-structural change around the pellet outer zone which is called the rim structure. It is observed at temperatures as low as 400°C so that fission track and cascade mixing could be the key mechanism. SEM observation revealed that the structure primarily appears on free surfaces of UO 2, indicating that strong sink for point defects may play a big role. And as generic observations, increase of lattice parameter indicates extensive amounts of vacancies are stored in high burnup fuel, which may induce the restructuring interacting with dislocations of high density at high burnup. Considering these observations a model of reaction-diffusion process of defects with irradiation induced transport is proposed. The equations are investigated numerically. The model indicates that an instability starts when the dislocation network starts intensive interaction with vacancy flux which is modified by interstitial diffusion between spatial segments. It appeared to be similar to the Turing type instability which indicates that the rim structure formation is one kind of the self-organizing processes of open reaction-diffusion systems.

  20. Influence of deformation on dolomite rim growth kinetics

    Helpa, Vanessa; Rybacki, Erik; Grafulha Morales, Luiz Fernando; Dresen, Georg

    2015-04-01

    Using a gas-deformation apparatus stacks of oriented calcite (CaCO3) and magnesite (MgCO3) single crystals were deformed at T = 750° C and P = 400 MPa to examine the influence of stress and strain on magnesio-calcite and dolomite (CaMg[CO3]2) growth kinetics. Triaxial compression and torsion tests performed at constant stresses between 7 and 38 MPa and test durations between 4 and 171 hours resulted in bulk strains of 0.03-0.2 and maximum shear strains of 0.8-5.6, respectively. The reaction rims consist of fine-grained (2-7 μm) dolomite with palisade-shaped grains growing into magnesite reactants and equiaxed granular dolomite grains next to calcite. In between dolomite and pure calcite, magnesio-calcite grains evolved with an average grain size of 20-40 μm. Grain boundaries tend to be straighter at high bulk strains and equilibrium angles at grain triple junctions are common within the magnesio-calcite layer. Transmission electron microscopy shows almost dislocation free palisades and increasing dislocation density within granular dolomite towards the magnesio-calcite boundary. Within magnesio-calcite grains, dislocations are concentrated at grain boundaries. Variation of time at fixed stress (˜17 MPa) yields a parabolic time dependence of dolomite rim width, indicating diffusion-controlled growth, similar to isostatic rim growth behavior. In contrast, the magnesio-calcite layer growth is enhanced compared to isostatic conditions. Triaxial compression at given time shows no significant change of dolomite rim thickness (11±2 μm) and width of magnesio-calcite layers (33±5 μm) with increasing stress. In torsion experiments, reaction layer thickness and grain size decrease from the center (low stress/strain) to the edge (high strain/stress) of samples. Chemical analysis shows nearly stoichiometric composition of dolomite palisades, but enhanced Ca content within granular grains, indicating local disequilibrium with magnesio-calcite, in particular for twisted

  1. Bone Cancer

    Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another ... more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and ...

  2. Bone Cancer

    Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another part of the body is more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 ...

  3. Bone Diseases

    Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly ... childhood and your teens, your body adds new bone faster than it removes old bone. After about ...

  4. Prostate cancer with lytic bone metastases: 18F-fluorodeoxyglucose positron emission tomography-computed tomography for diagnosis and monitoring response to medical castration therapy

    Lytic bone metastases are rare in prostate cancer. We here present 18 fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography computed tomography (PET-CT) images of a 67-year-old male patient with lytic metastases from prostate cancer. Repeat 18F-FDG PET-CT done 6 months later showed response to medical castration therapy. While the role of 18F-FDG PET-CT for sclerotic bone metastases in prostate cancer remains controversial, it appears to be useful for detection and response assessment of lytic prostate cancer metastases. (author)

  5. Non-destructive examination technique for steam turbine rotor disk rim cracking

    Turbine disk rim cracking in thermal and nuclear power plants has been a major reliability issue in recent years. This problem which includes both circumferential and radial direction cracking on the hidden face of rim fixation behind the blade hook has become very important in periodic non-destructive examination. To detect these defects, the UT inspection techniques using a conventional single angle probe and a phased array probe without removing blades from wheel rim are developed. This paper summarizes and discusses non-destructive examination methods for turbine rim cracking using phased array technique and other technique and these results. (author)

  6. Grain-rimming kaolinite in Permian Rotliegend reservoir rocks

    Waldmann, Svenja; Gaupp, Reinhard

    2016-04-01

    Upper Rotliegend sediments of Permian age from the northeast Netherlands show moderate to good reservoir qualities. The predominant control is by the presence of authigenic grain-rimming kaolinite, which has a negative, but in some parts also a positive, effect on reservoir quality. To better understand the formation and distribution of grain-rimming kaolinite, reservoir rocks were studied in terms of composition and diagenetic processes. Petrographic evidence, summarized as a paragenetic sequence, is integrated with geochemical modeling results to identify early mesodiagenetic water-rock interactions under the participation of gases, i.e., CO2 and H2S, released from underlying Carboniferous source rocks. The sediments investigated were deposited at varying distance from the southern flank of the Southern Permian Basin. Sediments near the basin margin are mainly attributed to a fluvial environment and comprise medium to coarse-grained sandstones and conglomerates. There, vermicular kaolinite occurs with a lath-like structure. Distal to the basin margin, mainly in sandstones intercalated with fine-grained playa sediments, comparatively high amounts of grain-rimming kaolinite occur. There, the presence of this mineral has a significant influence on the rock properties and the reservoir quality. Geochemical modeling suggests that the formation of such kaolinites cannot be explained exclusively by in situ feldspar dissolution. The modeling results support evidence that kaolinite can be formed from precursor clay minerals under the presence of CO2-rich formation waters. Such clay minerals could be corrensite, smectite-chlorite mixed-layer minerals, or chlorite that is potentially present in Rotliegend sediments during early diagenesis. Furthermore, the geochemical modeling can reflect several mineral reactions that were identified from petrographic analysis such as the formation of illite and kaolinite at the expense of feldspar dissolution and consequent silica

  7. Molecular markers for granulovacuolar degeneration are present in rimmed vacuoles.

    Masahiro Nakamori

    Full Text Available BACKGROUND: Rimmed vacuoles (RVs are round-oval cytoplasmic inclusions, detected in muscle cells of patients with myopathies, such as inclusion body myositis (IBM and distal myopathy with RVs (DMRV. Granulovacuolar degeneration (GVD bodies are spherical vacuoles containing argentophilic and hematoxyphilic granules, and are one of the pathological hallmarks commonly found in hippocampal pyramidal neurons of patients with aging-related neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These diseases are common in the elderly and share some pathological features. Therefore, we hypothesized that mechanisms of vacuolar formation in RVs and GVD bodies are common despite their role in two differing pathologies. We explored the components of RVs by immunohistochemistry, using antibodies for GVD markers. METHODS: Subjects included one AD case, eight cases of sporadic IBM, and three cases of DMRV. We compared immunoreactivity and staining patterns for GVD markers. These markers included: (1 tau-modifying proteins (caspase 3, cyclin-dependent kinase 5 [CDK5], casein kinase 1δ [CK1δ], and c-jun N-terminal kinase [JNK], (2 lipid raft-associated materials (annexin 2, leucine-rich repeat kinase 2 [LRRK2], and flotillin-1, and (3 other markers (charged multi-vesicular body protein 2B [CHMP2B] and phosphorylated transactive response DNA binding protein-43 [pTDP43] in both GVD bodies and RVs. Furthermore, we performed double staining of each GVD marker with pTDP43 to verify the co-localization. RESULTS: GVD markers, including lipid raft-associated proteins and tau kinases, were detected in RVs. CHMP2B, pTDP43, caspase 3, LRRK2, annexin 2 and flotillin-1 were detected on the rim and were diffusely distributed in the cytoplasm of RV-positive fibers. CDK5, CK1δ and JNK were detected only on the rim. In double staining experiments, all GVD markers colocalized with pTDP43 in RVs. CONCLUSIONS: These results suggest that RVs of muscle

  8. The status of water and sanitation among Pacific Rim nations.

    Arnold, Robert G; Heyworthz, Jane; Sáez, A Eduardo; Rodriguez, Clemencia; Weinstein, Phil; Ling, Bo; Memon, Saima

    2011-01-01

    Analysis of relationships among national wealth, access to improved water supply and sanitation facilities, and population health indices suggests that the adequacy of water resources at the national level is a poor predictor of economic development--namely, that low water stress is neither necessary nor sufficient for economic development at the present state of water stress among Pacific Rim nations. Although nations differ dramatically in terms of priority provided to improved water and sanitation, there is some level of wealth (per capita GNP) at which all nations promote the development of essential environmental services. Among the Pacific Rim countries for which there are data, no nation with a per capita GNP > US$18,000 per year has failed to provide near universal access to improved water supply and sanitation. Below US$18,000/person-year, however, there are decided differences in the provision of sanitary services (improved water supply and sanitation) among nations with similar economic success. There is a fairly strong relationship between child mortality/life expectancy and access to improved sanitation, as expected from the experiences of developed nations. Here no attempt is made to produce causal relationships among these data. Failure to meet Millennium Development Goals for the extension of improved sanitation is frequently evident in nations with large rural populations. Under those circumstances, capital intensive water and sanitation facilities are infeasible, and process selection for water/wastewater treatment requires an adaptation to local conditions, the use of appropriate materials, etc., constraints that are mostly absent in the developed world. Exceptions to these general ideas exist in water-stressed parts of developed countries, where water supplies are frequently augmented by water harvesting, water reclamation/reuse, and the desalination of brackish water resources. Each of these processes involves public acceptance of water

  9. ‘Sutureless’ transconjunctival approach for infraorbital rim fractures

    Nagaraj, Vaibhav; Ghosh, Abhishek; Nanjappa, Madan; Ramesh, Keerthi

    2015-01-01

    Aim: To analyze the ease and surgical outcome of using sutureless transconjunctival approach for repair of infra-orbital fractures. Design: Prospective clinical case series. Materials and Methods: Totally 5 patients with infra-orbital rim or orbital floor fractures were selected and the fractures were accessed through a pre-septal transconjunctival incision. After reduction and fixation, the conjunctiva was just re-approximated and re-draped into position. Incidence of post-operative complications such as diplopia, lid retraction, eyelid dystopia, foreign body granuloma and poor conjunctival healing was assessed at intervals of 1 week, 15 days and a month post-operatively. Results: No complications were observed in any of the 5 patients. Healing was satisfactory in all patients. Conclusion: The sutureless technique appears to be a time saving and technically simpler viable alternative to multilayered suturing in orbital trauma with minimal post-operative complications. PMID:25821377

  10. Land use change in Bohai Rim: a spatialtemporal analysis

    2001-01-01

    Based on RS and GIS methods, land use information for 1985 and1995 was acquired from TM images and analyzed. Then on both spatial and temporal aspects, this paper analyzes land use change in three provinces of Hebei, Shandong and Liaoning and two municipalities of Beijing and Tianjin in the Bohai Rim covering the period of 1985 to 1995. The extent, rate, areal difference and trend of various types of land use changes in the region, as well as spatial changes of major types of land use, their distribution characteristics and regional orientation are revealed. The regional characteristics of land use are elaborated, so as to provide effective policy support for sustainable land use in the area around the Bohai Bay.

  11. Donor corneoscleral rim contamination by gentamicin-resistant organisms

    Gopinathan Usha

    1994-01-01

    Full Text Available Gentamicin is the most widely used antibiotic in the decontamination of donor cornea for penetrating keratoplasty. However, the incidence of resistance to gentamicin is on the rise. Bacterial isolates from 178 donor corneal rims were studied for gentamicin sensitivity. The overall rate of gentamicin resistance was 63.4%. At 86.2% the Pseudomonas. species had the highest rate of resistance, followed by Streptococci at 84.6%. The high rate of gentamicin resistance encountered by us and others suggest that either addition of a second antibiotic to corneal storage media or replacement of gentamicin by an antibiotic with a broader spectrum of activity may help reduce the risk of endophthalmitis following penetrating keratoplasty

  12. Mass Movement on Vesta at Steep Scarps and Crater Rims

    Krohn, K.; Jaumann, R.; Otto, K.; Hoogenboom, T.; Wagner, R.; Buczkowski, D. L.; Garry, B.; Williams, D. A.; Yingst, R. A.; Scully, J.; De Sanctis, M. C.; Kneissl, T.; Schmedemann, N.; Kersten, E.; Stephan, K.; Matz, K.-D.; Pieters, C. M.; Preusker, F.; Roatsch, T.; Schenk, P.; Russell, C. T.; Raymond, C. A.

    2014-01-01

    The Quadrangles Av-11 and Av-12 on Vesta are located at the northern rim of the giant Rheasilvia south polar impact basin. The primary geologic units in Av-11 and Av-12 include material from the Rheasilvia impact basin formation, smooth material and different types of impact crater structures (such as bimodal craters, dark and bright crater ray material and dark ejecta material). Av-11 and Av-12 exhibit almost the full range of mass wasting features observed on Vesta, such as slump blocks, spur-and-gully morphologies and landslides within craters. Processes of collapse, slope instability and seismically triggered events force material to slump down crater walls or scarps and produce landslides or rotational slump blocks. The spur-and-gully morphology that is known to form on Mars is also observed on Vesta; however, on Vesta this morphology formed under dry conditions.

  13. Radiation hydrodynamical models of the inner rim in protoplanetary disks

    Flock, M; Turner, N J; Benisty, M

    2016-01-01

    Many stars host planets orbiting within a few astronomical units (AU). The occurrence rate and distributions of masses and orbits vary greatly with the host stars mass. These close planets origins are a mystery that motivates investigating protoplanetary disks central regions. A key factor governing the conditions near the star is the silicate sublimation front, which largely determines where the starlight is absorbed, and which is often called the inner rim. We present the first radiation hydrodynamical modeling of the sublimation front in the disks around the young intermediate-mass stars called Herbig Ae stars. The models are axisymmetric, and include starlight heating, silicate grains sublimating and condensing to equilibrium at the local, time-dependent temperature and density, and accretion stresses parametrizing the results of MHD magneto-rotational turbulence models. The results compare well with radiation hydrostatic solutions, and prove to be dynamically stable. Passing the model disks into Monte Ca...

  14. Epidemiology of trichinellosis in Asia and the Pacific Rim.

    Takahashi, Y; Mingyuan, L; Waikagul, J

    2000-12-01

    The epidemiology of trichinellosis, species of Trichinella present and the food and eating habits of people affected in Asia and the Pacific Rim are reviewed with emphasis on Japan, China and Thailand. Trichinella seems to be prevalent throughout this region although outbreaks of trichinellosis have not been reported in some areas. Major outbreaks of the disease have been reported primarily in China and Thailand. This is the result of three factors: (1) China and Thailand are highly endemic areas for this parasite; (2) the two countries are well-organized and there is a public health system that enables precise reporting of disease outbreaks and (3) culinary habits provide many opportunities to eat undercooked meats. Trichinella found in Asia and the Pacific Rim includes both encapsulated species (Trichinella spiralis, Trichinella britovi, Trichinella nativa) and noncapsulated species (Trichinella pseudospiralis, Trichinella papuae). T. britovi, isolated in Japan, is a different genotype from the European strain. Therefore, the Japanese strain of T. britovi is designated Trichinella T9. Human trichinellosis caused by T. pseudospiralis has occurred in New Zealand and Thailand. Tasmania has had animal cases of T. pseudospiralis infection and animals with T. papuae infection have been found in Papua New Guinea. Economic losses due to Trichinella infection are not negligible in China, where there have been more than 500 outbreaks of human trichinellosis, affecting more than 20,000 people and causing more than 200 deaths. In Thailand, over the past 27 years, 120 outbreaks were reported involving nearly 6700 patients and 97 deaths. Japan has had fewer outbreaks and some sporadic cases have been attributed to imported infection. PMID:11099839

  15. Radial Internal Material Handling System (RIMS) for Circular Habitat Volumes

    Howe, Alan S.; Haselschwardt, Sally; Bogatko, Alex; Humphrey, Brian; Patel, Amit

    2013-01-01

    On planetary surfaces, pressurized human habitable volumes will require a means to carry equipment around within the volume of the habitat, regardless of the partial gravity (Earth, Moon, Mars, etc.). On the NASA Habitat Demonstration Unit (HDU), a vertical cylindrical volume, it was determined that a variety of heavy items would need to be carried back and forth from deployed locations to the General Maintenance Work Station (GMWS) when in need of repair, and other equipment may need to be carried inside for repairs, such as rover parts and other external equipment. The vertical cylindrical volume of the HDU lent itself to a circular overhead track and hoist system that allows lifting of heavy objects from anywhere in the habitat to any other point in the habitat interior. In addition, the system is able to hand-off lifted items to other material handling systems through the side hatches, such as through an airlock. The overhead system consists of two concentric circle tracks that have a movable beam between them. The beam has a hoist carriage that can move back and forth on the beam. Therefore, the entire system acts like a bridge crane curved around to meet itself in a circle. The novelty of the system is in its configuration, and how it interfaces with the volume of the HDU habitat. Similar to how a bridge crane allows coverage for an entire rectangular volume, the RIMS system covers a circular volume. The RIMS system is the first generation of what may be applied to future planetary surface vertical cylinder habitats on the Moon or on Mars.

  16. OBS FOMAR POOL: Gibraltar and ALERTES-RIM experiments.

    Pazos, Antonio; Martín Davila, Jose; Buforn, Elisa; Cabieces, Roberto; Santos, Jose; Sandoval, Nicolas; Roca, Antoni; Dahm, Torsten

    2016-04-01

    The Eurasian-African plate boundary crosses the called "Ibero-Maghrebian" region from the San Vicente Cape (SW Portugal) to Tunisia including the south Iberia, Alboran Sea, and northern of Morocco and Algeria. The low convergence rate at this plate boundary produces a continuous moderate seismic activity of low magnitude and shallow depth, where the occurrence of large earthquakes is separated by long time intervals, even with associated tsunamis, like the 1755 Lisbon earthquake. In this region, there are also intermediate and very deep earthquakes. Due to the fact that part of the seismic activity is located at marine areas, and also because of the poor geographic azimuthal coverage at some zones provided by the land stations (specially in the SW of the San Vicente Cape area), Royal Spanish Navy Observatory (ROA) acquired three "LOSTERN" broad band (CMG-40T sensors) OBS, manufactured by KUM (Kiel, Germany), and, more recently (2014), the Complutense University of Madrid (UCM) acquired another three with Trillium 120 sensors. All of them conform the OBS FOMAR pool. Since January to November 2014, the FOMAR pool has been deployed along the Gibraltar strait (Gibraltar experiment), in collaboration with SECEGSA (Spanish society to study the fix communication through the Gibraltar Strait), to study the local microseismicity in the Gibraltar strait area. Also, since September 2015, the FOMAR pool has been deployed for 8 months in SW of the San Vicente Cape with an hexagonal array configuration as a part of ALERTES-RIM project. In this work the some preliminary results of the Gibraltar strait and ALERTES-RIM OBS experiment are shown.

  17. Ultrastructural Analyses of Alveolar Bone in a Patient With Osteomyelitis Secondary to Osteopetrosis: A Review of the Literature.

    Mikami, Toshinari; Miake, Yasuo; Bologna-Molina, Ronell; Takeda, Yasunori

    2016-08-01

    Osteopetrosis is a generic term for generalized sclerotic conditions caused by rare genetic disorders. Decreased osteoclastic activities disturb bone remodeling, resulting in greater mineral density and greater compressive strength; therefore, bone fracture is a major physical symptom of osteopetrosis. Osteomyelitis of the maxilla or mandible is a common and well-documented complication of osteopetrosis. Local infection, such as odontogenic infection, is more likely to lead to osteomyelitis, and treatment strategies can be challenging. However, detailed ultrastructural analyses of bone from patients with osteopetrosis and odontogenic infection are limited. This report describes a case of osteomyelitis of the maxilla and mandible secondary to osteopetrosis in an adult patient and presents ultrastructural data of alveolar bone tissue analyzed by contact microradiography, electron probe microanalysis, and x-ray diffraction. Cases of osteomyelitis of the jaw secondary to osteopetrosis also are reviewed. PMID:27000409

  18. 49 CFR 238.119 - Rim-stamped straight-plate wheels.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Rim-stamped straight-plate wheels. 238.119 Section... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PASSENGER EQUIPMENT SAFETY STANDARDS Safety Planning and General Requirements § 238.119 Rim-stamped straight-plate wheels. (a)(1) Except as provided in paragraph (a)(2) of...

  19. 16 CFR Figure 8 to Part 1512 - Reflectorized Bicycle Wheel Rim Abrasion Test Device

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Reflectorized Bicycle Wheel Rim Abrasion Test Device 8 Figure 8 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL...—Reflectorized Bicycle Wheel Rim Abrasion Test Device EC03OC91.074...

  20. Analysis of bubble pressure in the rim region of high burnup PWR fuel

    Koo, Yang Hyun; Lee, Byung Ho; Sohn, Dong Seong [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-02-01

    Bubble pressure in the rim region of high burnup PWR UO{sub 2} fuel has been modeled based on measured rim width, porosity and bubble density. Using the assumption that excessive bubble pressure in the rim is inversely proportional to its radius, proportionality constant is derived as a function of average pellet burnup and bubble radius. This approach is possible because the integration of the number of Xe atoms retained in the rim bubbles, which can be calculated as a function of bubble radius, over the bubble radius gives the total number of Xe atoms in the rim bubbles. Here the total number of Xe atoms in the rim bubbles can be derived from the measured Xe depletion fraction in the matrix and the calculated rim thickness. Then the rim bubble pressure is obtained as a function of fuel burnup and bubble size from the proportionality constant. Therefore, the present model can provide some useful information that would be required to analyze the behavior of high burnup PWR UO{sub 2} fuel under both normal and transient operating conditions. 28 refs., 9 figs. (Author)

  1. From Theory to Practice: "Kaizen" and the Academy of the Pacific Rim

    Blasdale, Spencer

    2004-01-01

    In this article, the author profiles the Academy of the Pacific Rim Charter Public School (Hyde Park, Massachusetts) and describes the school's culture. The school's students, who are in grades 6 through 12, are surrounded by rituals, routines, and relationship-building activities. Pacific Rim's culture stems from and supports the school's…

  2. Alkoholinių gėrimų reklamos situacija Lietuvoje

    Maknavičiūtė, Vaida

    2008-01-01

    Darbo tikslas. Išanalizuoti alkoholinių gėrimų reklamos situaciją Lietuvoje, gyventojų požiūrį į jos draudimą. Darbo uždaviniai. 1. Išanalizuoti esamą alkoholinių gėrimų reklamą. 2. Nustatyti moksleivių požiūrį į alkoholinių gėrimų reklamą. 3. Nustatyti gyventojų požiūrį į alkoholinių gėrimų reklamos draudimą. 4. Išanalizuoti esminius reklamos kūrimo principus, įvertinti jų naudojimą reklamuojant alkoholinius gėrimus. 5. Įvertinti esamos alkoholinių gėrimų reklamos atitikim...

  3. Bone Densitometry (Bone Density Scan)

    ... of DXA Bone Densitometry? What is a Bone Density Scan (DXA)? Bone density scanning, also called dual-energy x-ray absorptiometry ( ... is today's established standard for measuring bone mineral density (BMD). An x-ray (radiograph) is a noninvasive ...

  4. Low Bone Density

    ... Density Exam/Testing › Low Bone Density Low Bone Density Low bone density is when your bone density ... people with normal bone density. Detecting Low Bone Density A bone density test will determine whether you ...

  5. Effect of PCMI restraint on bubble size distribution in the rim structure of UO2 fuel

    Generally, the bubble size in the rim structure of UO2 is not dependent on the fuel burnup and the bubble pressure is higher than that in the equilibrium condition. However it was also observed that if the fuel pellet is not restrained, the size of the bubbles in the rim structure could be larger than that in the restraint condition. Although the wide variety of rim bubble sizes and porosities possibly result from an external restrain effect, the quantitative method to analyze the effect of PCMI restraint on bubble distribution in the rim is not available at the moment. In this paper, a method is developed which can be used to analyze the effect of PCMI restraint on the bubble distribution in the rim structure of UO2 fuel based on the data in the literatures. The total number of Xe atoms in the rim bubbles per unit rim volume could be derived by a summation of the number of Xe atoms of each rim bubble in a unit rim volume. The number of Xe atoms of each rim bubble could be calculated by the Van der Waals equation of state and the pressure expressed by p=σ+C/r, where C is an unknown constant to be determined as a function of the temperature and the burnup. On the other hand, the total number of Xe atoms in the rim bubbles per unit rim volume can also be calculated by Xe depression data. If the fuel pellet is not restrained, the uniform hydrostatic stress, σ is zero. Hence if the data of the fuel disk without a restraint is used, a constant C can be obtained at 823K and a local burnup of 90 GWd/t. Although the local burnup of PCMI restraint case is slightly different from that without PCMI restraint, the value derived above is used for the analysis of PCMI restraint case. The calculated bubble distribution with PCMI restraint was similar to the measured one. Because the effect of PCMI restraint on bubble size increased with the bubble size, the development of a large bubble was suppressed. Hence, the PCMI restraint caused a typical bubble size in the rim and

  6. Chondrule Rims in Murchison, Cathodoluminescence Evidence for In Situ Formation by Aqueous Alteration

    Sears, D. W. G.; Jie, Lu; Benoit, P. H.

    1992-07-01

    The fine-grained rims on ordinary and carbonaceous chondrite chondrules are often regarded as accretionary, mainly because they are often volatile-rich (King and King, 1981). However, Sears et al. (1991) recently argued that some chondrule rims in CM chondrites may be the result of aqueous alteration. The rims, like many features in primitive chondrites, stand out especially clearly in cathodoluminescence (CL) imagery due to the distinctive bright red CL of their abundant fine-grained forsterite. Chondrules similarly stand out well in CL images. Group A chondrules show the strong red CL of Fe-free olivine, sometimes associated with the bright yellow CL of anorthite- normative mesostases, while group B chondrules containing Fe-rich olivines and quartz-normative mesostases do not produce CL (Sears et al., 1992). Using a CL mosaic, we measured chondrule and rim diameters for every chondrule in a 17x10 mm section of Murchison. 38% of the chondrules were group A, compared with 46% in the Semarkona (LL3.0) and 61% in the Dhajala (H3.8) ordinary chondrites. While both group A and group B chondrules have rims, those on group A chondrules are significantly thicker than those on group B chondrules, the rim-to-diameter ratios being 0.2-0.5 for group A chondrules and 0.1-0.2 for group B chondrules (Fig. 1). There are two reasonable explanations for the relationship between rim thickness and chondrule group. Either (1) the composition of chondrule mainly determines the thickness of the rim, e.g., the rims were produced by the aqueous alteration of the host chondrule, or (2) the two chondrule groups were formed in different environments, say a very dusty locale favoring thick rims versus a less favorable relatively dust-free location. We note that (a) both types of chondrule coexist in the same rock, (b) CL textures at the rim/matrix are sharp while at the rim/chondrule interface they are irregular (see Fig. 7d,e in Sears et al., 1991), (c) all faces on the objects in Murchison

  7. The significance of echogenic rim of atypical hepatic hemangioma on ultrasonogram

    To evaluate whether the presence of a peripheral echogenic rim surrounding internal low echogenicity is helpful in the diagnosis of atypical hepatic hemangioma. Within a two-year period, a retrospective review of the sonographic appearances of 24 atypical hemangiomas in 21 patients was performed. Diagnosis was made by dynamic and delayed enhanced CT, MR imaging or clinical follow up for one year, including follow-up sonogram. The sonographic appearances of these hemangiomas were analyzed for pattern and thickness of the echogenic rim, internal echo pattern, shape, and size. Additionally, forty six lesions of hepatoma, metastasis, abscess and intrahepatic cholangiocarcinoma confirmed by pathology within the same period were also evaluated for the presence of echogenic rim. Twenty-three of 24 lesions showed an echogenic rim;these were thick in nine cases, and thin in 14 cases. The thickness of the rim was either uniform(n=10) or eccentric(n=13). The average maximum diameter of atypical hemangioma was 4.4cm(range of diameters, 1.5-12cm). The internal echo pattern was partially or entirely hypoechoic in 15 lesions, homogeneously isoechoic in three, and mixed in six cases. Twenty-one lesions were round, and the shape of three was irregular. The other forty six masses including hepatocellular carcinoma, metastases, cholangiocarcinoma and hepatic abscesses did not show an echogenic rim. The presence of a sonographic echogenic rim in a hepatic mass may help in the diagnosis of hepatic hemangioma

  8. The significance of echogenic rim of atypical hepatic hemangioma on ultrasonogram

    Lee, Choon Hyeong; Ko, Young Tae; Lee, Dong Ho; Lim, Joo Won; Yoon, Yup [Kyunghee Univ. Hospital, Seoul (Korea, Republic of)

    1996-11-01

    To evaluate whether the presence of a peripheral echogenic rim surrounding internal low echogenicity is helpful in the diagnosis of atypical hepatic hemangioma. Within a two-year period, a retrospective review of the sonographic appearances of 24 atypical hemangiomas in 21 patients was performed. Diagnosis was made by dynamic and delayed enhanced CT, MR imaging or clinical follow up for one year, including follow-up sonogram. The sonographic appearances of these hemangiomas were analyzed for pattern and thickness of the echogenic rim, internal echo pattern, shape, and size. Additionally, forty six lesions of hepatoma, metastasis, abscess and intrahepatic cholangiocarcinoma confirmed by pathology within the same period were also evaluated for the presence of echogenic rim. Twenty-three of 24 lesions showed an echogenic rim;these were thick in nine cases, and thin in 14 cases. The thickness of the rim was either uniform(n=10) or eccentric(n=13). The average maximum diameter of atypical hemangioma was 4.4cm(range of diameters, 1.5-12cm). The internal echo pattern was partially or entirely hypoechoic in 15 lesions, homogeneously isoechoic in three, and mixed in six cases. Twenty-one lesions were round, and the shape of three was irregular. The other forty six masses including hepatocellular carcinoma, metastases, cholangiocarcinoma and hepatic abscesses did not show an echogenic rim. The presence of a sonographic echogenic rim in a hepatic mass may help in the diagnosis of hepatic hemangioma.

  9. Bone metastases as the presenting manifestation of rhabdomyosarcoma in childhood

    Rarely, rhabdomyosarcoma can present with bone pain and bone lesions on radiographs without evidence of a primary tumor. Of 428 children with biopsy-proven rhabdomyosarcoma, four presented with radiographic evidence of bone metastases, but no primary tumor was found on subsequent evaluation. On radiographs, these metastases, located most commonly in the metaphyses of the extremities and in the spine, displayed a destructive or diffusely permeative pattern without sclerotic margins and mimicked the more common neuroblastoma. One patient also had diaphyseal cortical lytic metastases of the tibia. Radiographs defined metastases of the extremities better than the correlative bone scans. In the spine, on T2-weighted magnetic resonance (MR) images, metastases displayed high signal intensity which contrasted with the low-signal-intensity marrow in these pediatric patients. On histopathologic examination, metastatic rhabdomyosarcoma was composed of small cells of variable size, shape, and growth pattern similar to other round cell tumors. A positive desmin immunohistochemical test helped to establish the diagnosis. The radiologist, pathologist, and clinician should be aware of this unusual presentation of rhabdomyosarcoma so that suitable immunohistochemical tests are performed and appropriate chemotherapy given. (orig.)

  10. CT Guided Bone Biopsy Using a Battery Powered Intraosseous Device

    Schnapauff, Dirk, E-mail: dirk.schnapauff@charite.de; Marnitz, Tim, E-mail: tim.marnitz@charite.de; Freyhardt, Patrick, E-mail: Patrick.freyhardt@charite.de; Collettini, Federico, E-mail: Federico.collettini@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany); Hartwig, Kerstin, E-mail: kerstin.hartwig@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Haematology and Oncology (Germany); Joehrens, Korinna, E-mail: korinna.joehrens@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Pathology (Germany); Hamm, Bernd, E-mail: bernd.hamm@charite.de; Kroencke, Thomas, E-mail: thomas.kroencke@charite.de; Gebauer, Bernhard, E-mail: Bernhard.gebauer@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany)

    2013-10-15

    Purpose: To evaluate the feasibility of a battery powered intraosseous device to perform CT-fluoroscopy guided bone biopsy. Methods: Retrospective analysis of 12 patients in whom bone specimen were acquired from different locations under CT-fluoroscopy guidance using the OnControl bone marrow biopsy system (OBM, Vidacare, Shavano Park, TX, USA). Data of the 12 were compared to a historic cohort in whom the specimen were acquired using the classic Jamshidi Needle, as reference needle using manual force for biopsy. Results: Technical success was reached in 11 of 12 cases, indicated by central localisation of the needle within the target lesion. All specimen sampled were sufficient for histopathological workup. Compared to the historical cohort the time needed for biopsy decreased significantly from 13 {+-} 6 to 6 {+-} 4 min (P = 0.0001). Due to the shortened intervention time the radiation dose (CTDI) during CT-fluoroscopy was lowered significantly from 169 {+-} 87 to 111 {+-} 54 mGy Multiplication-Sign cm (P = 0.0001). Interventional radiologists were confident with the performance of the needle especially when using in sclerotic or osteoblastic lesions. Conclusion: The OBM is an attractive support for CT-fluoroscopy guided bone biopsy which is safe tool and compared to the classical approach using the Jamshidi needle leading to significantly reduced intervention time and radiation exposure.

  11. Bone tumor

    ... physical exam. Tests that may be done include: Alkaline phosphatase blood level Bone biopsy Bone scan Chest x- ... also affect the results of the following tests: Alkaline phosphatase isoenzyme Blood calcium level Parathyroid hormone Blood phosphorus ...

  12. Cooling of Gas Turbines. 2; Effectiveness of Rim Cooling of Blades

    Wolfenstein, Lincoln; Meyer, Gene L.; McCarthy, John S.

    1945-01-01

    An analysis of rim cooling, which cools the blade by condition alone, was conducted. Gas temperatures ranged from 1300 degrees to 1900 degrees F and rim temperatures from 0 degrees to 1000 degrees F below gas temperatures. Results show that gas temperature increases up to 200 degrees F are permissible provided that the blades are cooled by 400 degrees to 500 degrees F below the gas temperature. Relatively small amounts of blade cooling, at constant gas temperature, give large increases in blade life. Dependence of rim cooling on heat-transfer coefficient, blade dimensions, and thermal conductivity is determined by a single parameter.

  13. Amphibole Reaction Rims in Response to Decompression compared to Heating: An Experimental Approach

    Browne, B. L.; Gardner, J. E.; Larsen, J.

    2003-12-01

    Amphiboles are an important magmatic mineral phase common to a variety of volcanic settings, and are especially sensitive to variations in the water content and temperature of the surrounding induced during magmatic ascent or heating accompanying magma mixing events. As magma rises toward the surface hydrous amphiboles, stable at high water pressures, break down in response to degassing of the surrounding melt. Reaction rims also form around amphiboles that are destabilized when mixing with hotter, more primitive magmas occurs. In this study, we compare the thickness, composition, and rate of formation of amphibole reaction rims during a series of isothermal decompression and isobaric heating experiments using dacite and andesite magmas erupted from Redoubt volcano, Alaska in 1989-1990. The 1989-90 Redoubt dacite pumice consists of magnesio-hornblendes, plagioclase, othropyroxene, and Fe-Ti oxides in a high-silica rhyolite glass. In contrast, 1989-90 Redoubt andesite contains pargasitic amphiboles, orthopyroxene, clinopyroxene, plagioclase, and Fe-Ti oxides in a rhyodacite glass. Our results indicate that the reaction rims formed in response to decompression are distinguishable in thickness, grain size, and type of mineral formed in the rims from those formed in response to heating, regardless of the type of amphibole studied. First, decompression induced rims were thinner (5- 50 um) compared to those developing in response to heating (25- 200 um). Decompression induced rim growth rate ranges from 0.3 to 0.6 um/day compared to heating induced rim growth rate, which ranges from 0.4 to 1.6 um/day. Second, decompression rims were finer-grained (5-15 um diameter crystals) compared to heating reaction rims (5- 35 um diameter crystals). And third, decompression rims are predominantly composed of orthopyroxene and plagioclase, with lesser amounts of Fe-Ti oxides, whereas reaction rims that grew in response to heating experiments were composed almost entirely of

  14. Experimental investigation of the nebular formation of chondrule rims and the formation of chondrite parent bodies

    Beitz, Eike; Blum, Jürgen; Mathieu, Romain; Pack, Andreas; Hezel, Dominik C.

    2011-01-01

    We developed an experimental setup to test the hypothesis that accretionary dust rims around chondrules formed in the solar nebula at elevated temperatures. Our experimental method allows us to form dust rims around chondrule-analogs while being levitated in an inert-gas flow. We used micrometer-sized powdered San Carlos olivine to accrete individual dust particles onto the chondrule-analog at a temperature of 1100{\\deg}C. The resulting dust-rims were analyzed by means of two different techni...

  15. RIM, Munc13, and Rab3A interplay in acrosomal exocytosis

    Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: ► RIM and Munc13 are present in human sperm and localize to the acrosomal region. ► RIM and Munc13 are necessary for acrosomal exocytosis. ► RIM and Munc13 participate before the acrosomal calcium efflux. ► RIM, Munc13 and Rab3A interplay in human sperm acrosomal exocytosis. ► RIM and Rab3A

  16. RIM, Munc13, and Rab3A interplay in acrosomal exocytosis

    Bello, Oscar D.; Zanetti, M. Natalia [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Mayorga, Luis S. [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Michaut, Marcela A., E-mail: mmichaut@fcm.uncu.edu.ar [Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Instituto de Ciencias Basicas, Universidad Nacional de Cuyo, Mendoza (5500) (Argentina)

    2012-03-10

    Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: Black-Right-Pointing-Pointer RIM and Munc13 are present in human sperm and localize to the acrosomal region. Black-Right-Pointing-Pointer RIM and Munc13 are necessary for acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Munc13 participate before the acrosomal calcium efflux. Black

  17. Out of the Blue: The Pacific Rim as a Region

    Arturo Santa-Cruz

    2005-08-01

    Full Text Available In 1993, in advance of what was to be the first Asia Pacific Economic Cooperation (APEC leader’s summit, US president Bill Clinton gave a lecture at Waseda University in Japan. In his speech, Clinton called for the creation of a “community of the Pacific.” The idea of a Pacific community is neither Clinton’s nor the Democratic Party’s invention, however. In the previous decade Ronald Reagan had already used it, going even beyond later conceptualizations, by referring to the 21st century as the Pacific’s century. But Reagan's prophecy concerning the Great Ocean was not new back in the 1980s either. In 1900 then US Secretary of State John Hay wrote: “the Mediterranean is the ocean of the past, the Atlantic the ocean of the present and the Pacific is the ocean of the future.” In a more general manner, as Christopher Coker has observed, the notion of the “Century of the Pacific” is plausible because it is consistent with the idea, popularized by Hegel, that the spirit of civilization is moving toward that part of the globe. Thus, the century of the Pacific has become a kind of zeitgeist. In this paper I undertake a conceptual, historical, and theoretical journey through the “Pacific Rim” or “Asia-Pacific,” as it has been called more recently. Although I will question the utility of the term, I want to make clear that my purpose is only to undertake a critical survey of “the Pacific.” As in any trip, however, one needs a starting point. But, What is the starting point of the Pacific Rim, that geographic zone that has been compared to Pascal’s sphere: “with periphery indeterminable and a center that may be anywhere”?

  18. Comperative study on four different radiographic technics to image the navicular bone

    In this paper the conventional x-ray technique according to Oxspring is compared with tomography and digitalized picture techniques (digital luminescent radiography, computed tomography, nuclear magnetic resonance tomography) to establish whether an improved picture of the equine navicular bone is possible. Because of a lack of detail, nuclear magnetic resonance tomography and digital luminescent radiography show no advantage. With tomography good picture of the navicular bone as well as the sesamoidian canals is gained, but the bone structure is not sharply visible. In spite of small losses in picture resolution, the computed tomography gives a picture with good contour and bone structure as well as an excellent differentiation between the density of spongiotic and sclerotic bone. When considering the picture quality (contour and structure of the navicular bone as well as number, shape, depth and surroundings of the sesamoidian canals), costs and technical possibilities of the examination procedures, the x-ray technique according to Oxspring still remains the method of choice in examining the equine navicular bone

  19. Investigations into the value of bone scintigrams in fracture of the navicular bone

    The diagnostic value of bone scintigrams was investigated in a group of 22 patients showing fractured navicular bones and contrasted with that of X-ray pictures and clinical evaluations. The changes revealed by radiology were pseudarthrosis (9 patients), complete fracture (10 patients) as well as cysts and sclerotic processes (3 patients). Eight out of 9 cases of pseudarthrosis, 6 of the 10 complete fractures and 2 of the 3 cysts were confirmed by corresponding pathological changes in the scintigrams. The X-ray pictures and clinical evaluations led to consistent results in 14 patients, conformity of the scintigrams and clinical findings was seen in 17 cases and of the X-ray pictures and scintigrams in 15 cases. The results of the study give evidence of the fact that scintigrams recorded after injection of 99 mTc MDP are primarily suitable to diagnose incipient pathological changes in the tissue adjacent to the fracture. Their use is justified in discrepancies between the clinical and radiological findings or in cases, where conventional X-rays yielded doubtful results as to the therapeutic strategy or incapacitation of the patient. (TRV)

  20. Results of auricular helical rim reconstruction with post-auricular tube flap

    Iljin Aleksandra

    2016-01-01

    Full Text Available The aim of the study was to present our experience with post-auricular tube flap (ptf and clinical evaluation of the results following auricular helical rim reconstruction with this technique in patients after trauma.

  1. Seismic Velocity Study of the Rim Uplift of the Steen River Impact Crater

    Niccoli, M.; Hildebrand, A. R.; Lawton, D. C.

    2005-03-01

    The structure of the rim uplift at the 25 km diameter Steen River has been explored by 2D and 3D seismic reflection and refraction techniques, constrained by downhole well surveys. A complicated deformation history is revealed.

  2. Reaction rim growth on olivine in silicic melts: Implications for magma mixing

    Coombs, M.L.; Gardner, J.E.

    2004-01-01

    Finely crystalline amphibole or pyroxene rims that form during reaction between silicic host melt and cognate olivine xenocrysts, newly introduced during magma mixing events, can provide information about the timing between mixing and volcanic eruptions. We investigated rim growth experimentally by placing forsteritic olivine in rhyolitic and rhyodacitic melts for times between 25 and 622 h at 50 and 150 MPa, H2O-saturated, at the Ni-NiO buffer. Rims of orthopyroxene microlites formed from high-silica rhyolite and rhyodacite melts at 885??C and 50 MPa, and in the rhyolite at 150 MPa and 885??C. Rims of amphibole with lesser orthopyroxene formed in the rhyolite at 150 MPa and 800??C and in the rhyodacite at 150 MPa and 885??C. Irregular, convolute olivine edges and mass balance between olivine, melt, and rim phases show that olivine partly dissolved at all conditions. Iron-rich zones at the exteriors of olivines, which increased in width parabolically with time, show that Fe-Mg interdiffusion occurring in olivines was not outpaced by olivine dissolution. Linear increases of the square of rim widths with time suggest that diffusion within the melt is the rate-controlling process for olivine dissolution and rim growth. Rims grew one-half to one order-of-magnitude faster when melt water contents were doubled, unless conditions were far above the liquidus. Rim growth rate in rhyolite increases from 0.055 ?? 0.01 ??m2/h at 885 ??C and 50 MPa to 0.64 ?? 0.13 ??m2/h at 800 ??C and 150 MPa. Melt composition has a lesser effect on rim growth rates, with growth rate increasing as melt SiO2 content decreases. Pyroxene rims on olivines in andesite erupted from Arenal volcano (Costa Rica) grew at a rate of 3.0 ?? 0.2 ??m2/h over an eleven-year period. This rate is faster than those of the experiments due to lower melt viscosity and higher temperatures, and suggests that a magma mixing event preceded the start of the eruption by days.

  3. The Anatomy and Bulk Composition of CAI Rims in the Vigarano (CV3) Chondrite

    Ruzicka, A.; Boynton, W. V.

    1993-07-01

    A striking feature of Ca,Al-rich inclusions (CAIs) in chondrites is the presence of mineralogical layers that typically form rim sequences up to 50 micrometers thick [1]. Many ideas regarding the origin of CAI rims have been proposed, but none are entirely satisfactory. The detailed mineralogy and bulk compositions of relatively unaltered CAI rims in the Vigarano (CV3) chondrite described here provide constraints on hypotheses of rim formation. Rim Mineralogy: CAIs in Vigarano consist of melilite (mel)- and spinel (sp)- rich varieties, both of which are rimmed [2]. Around mel-rich objects, the layer sequence is CAI interior --> sp-rich layer (sometimes absent) --> mel/anorthite (anor) layer --> Ti-Al-rich clinopyroxene (Tpx) layer --> Al- diopside (Al-diop) layer --> olivine (ol) +/- Al-diop layer --> host matrix. The sequence around sp-rich objects differs from this in that the mel/anor layer is absent. Both the sp-rich layer around mel-cored CAIs and the cores of sp-rich CAIs in Vigarano are largely comprised of a fine-grained (anor layer is sometimes monomineralic, consisting of mel alone, or bimineralic, consisting of both mel and anor. Where bimineralic, anor typically occurs in the outer part of the layer. In places, anor (An(sub)99-100) has partially altered to nepheline and voids. Rim mel is systematically less gehlenitic than mel in the CAI interiors, especially compared to mel in the interior adjacent to the rims. The Tpx layer (>2 and up to 15 wt% TiO2) and Al-diop layer ( sp + fo --> sp + fo + anor or mel or Tpx) that does not correspond to observed rim sequences. It thus appears that (1) the rim region did not form through crystallization of molten CAIs; and (2) rim layers did not originate solely by the crystallization of a melt layer present on a solid CAI core [4,5]. References: [1] Wark D. A. and Lovering J. F. (1977) Proc. LSC 8th, 95-112. [2] Ruzicka A. and Boynton W. V. (1991) Meteoritics, 26, 390-391. [3] Stolper E. (1982) GCA, 46, 2159

  4. Reken- en informatiesysteem Milieuhygiene: functioneel ontwerp voor de automatisering van het RIM

    Maas RJM; van der Plaat J; Ros JPM; Swart RJ; Wippler JC; Jansen HMA; Olsthoorn; A. A.

    1986-01-01

    Dit rapport beschrijft de 2e fase (volgens de System Development Method) van het project "Automatisering RIM". Nadruk ligt op de specificatie van de eisen die de opdrachtgever aan het systeem stelt. De verantwoordelijkheden en mogelijkheden van beheerder en gebruiker worden beschreven, uitgaande van de gewenste input en output van het RIM-systeem. Een gebruiker zal scenario's kunnen kiezen of aanpassen en maatregelenpakketten kunnen samenstellen teneinde emissie-scenario's...

  5. Application of RIMS to the study of noble gases in meteorites

    The paper examines the possibility of using Resonance Ionization Multiphoton Spectroscopy (RIMS) for individual atom counting of noble gases in meteorites. A description is given of the techniques to extract the gases from the meteorites, as well as the noble gas components. Application of RIMS to meteoritic noble gases is discussed with respect to: sample weights required for analysis, problems of adsorbed atomospheric gases on the samples, and the sensitivity of the spectrometer. (U.K.)

  6. Bestimmung der Ionisationsenergie von Actinium und Ultraspurenanalyse von Plutonium mit resonanter Ionisationsmassenspektrometrie (RIMS)

    Waldek, Achim Marcus

    2001-01-01

    ZusammenfassungDie Resonanzionisationsmassenspektrometrie (RIMS) verbindet hohe Elementselektivität mit guter Nachweiseffizienz. Aufgrund dieser Eigenschaften ist die Methode für Ultraspurenanalyse und Untersuchungen an seltenen oder schwer handhabbaren Elementen gut geeignet. Für RIMS werden neutrale Atome mit monochromatischem Laserlicht ein- oder mehrfach resonant auf energetisch hoch liegende Niveaus angeregt und anschließend durch einen weiteren Laserstrahl oder durch ein elektrisches Fe...

  7. Fission gas release behavior in high burnup UO2 fuels with developed rim-structure

    The effect of rim structure formation and external restraint pressure on fission gas release at transient conditions has been examined by using an out-of-pile high pressure heating technique for high burnup UO2 fuels (60, 74 and 90 GWd/t), which had been irradiated in test reactors. The latter two fuels bore a developed rim structure. The maximum heating temperature was 1500 degC, and the external pressures were independently controlled in the range of 10-150 MPa. The present high burnup fuel data were compared with those of previously studied BWR fuels of 37 and 54 GWd/t with almost no rim structure. The fission gas release and bubble swelling due to the growth of grain boundary bubbles and coarsened rim bubbles were effectively suppressed by the strong restraint pressure of 150 MPa for all the fuels; however the fission gas release remarkably increased for the two high burnup fuels with the developed rim structure, even at the strong restraint conditions. From the stepwise de-pressurization tests at an isothermal condition of 1500degC, the critical external pressure, below which a large burst release due to the rapid growth and interlinkage of the bubbles abruptly begins, was increased from a 40-60 MPa level for the middle burnup fuels to a high level of 120-140 MPa for the rim-structured high burnup fuels. The high potential for transient fission gas release and bubble swelling in the rim-structured fuels was attributed to highly over-pressurized fission gases in the rim bubbles. (author)

  8. Intraosseous Ganglion Cyst of the Lunate

    Nazerani, Shahram; Ebrahimpour, Adel; Najafi, Arvin; Shams Koushki, Ehsan

    2012-01-01

    Intraosseous ganglia can affect the carpal bones of the hand and must be considered in the differential diagnosis of wrist pain. A 38-year-old female presented with a 14-month history of left wrist pain and a radiolucent cystic lesion was seen computed tomography (CT) scanning. Characteristic radiographic findings of a cyst in association with a fine sclerotic rim was apparent. We report an unusual presentation of a ganglion cyst in the lunate bone with excellent treatment outcome.

  9. Experimental investigation of the nebular formation of chondrule rims and the formation of chondrite parent bodies

    Beitz, Eike; Mathieu, Romain; Pack, Andreas; Hezel, Dominik C

    2011-01-01

    We developed an experimental setup to test the hypothesis that accretionary dust rims around chondrules formed in the solar nebula at elevated temperatures. Our experimental method allows us to form dust rims around chondrule-analogs while being levitated in an inert-gas flow. We used micrometer-sized powdered San Carlos olivine to accrete individual dust particles onto the chondrule-analog at a temperature of 1100{\\deg}C. The resulting dust-rims were analyzed by means of two different techniques: one sample was investigated with non-destructive micro computer tomography, the other with a scanning electron microscope. Both methods give very similar results for the dust-rim structure and a mean dust-rim porosity of 60 percent, demonstrating that both methods are equally well suited for sample analysis. The chondrule-analog's bulk composition has no measurable effect on the accretion efficiency of the dust. We measured the chemical composition of chondrule-analog and dust-rim to check whether elemental exchange...

  10. Magnetic-Field Amplification in the Thin X-ray Rims of SN1006

    Ressler, Sean M; Reynolds, Stephen P; Long, Knox S; Petre, Robert; Williams, Brian J; Winkler, P Frank

    2014-01-01

    Several young supernova remnants (SNRs), including SN1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50 to $100 \\mu$G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic-field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic-field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, $D \\propto E^{\\mu}$. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the full widths at half maximum (FWHM) in terms of energy as FW...

  11. [Bone diseases].

    Uebelhart, Brigitte; Rizzoli, René

    2016-01-13

    Calcium intake shows a small impact on bone mineral density and fracture risk. Denosumab is a more potent inhibitor of bone resorption than zoledronate. Abaloparatide, PTHrP analog, increases bone mineral density and decreases fracture incidence. Teriparatide could be delivered via a transdermic device. Romosozumab and odanacatib improve calculated bone strength. Sequential or combined treatments with denosumab and teriparatide could be of interest, but not denosumab followed by teriparatide. Fibrous dysplasia, Paget disease and hypophosphatasia are updated, as well as atypical femoral fracture and osteonecrosis of the jaw. PMID:26946704

  12. Study on thd relationship between serum fibrosis markers levels, bone marrow scintigraphy patterns and clinical staging in patients with chronic ldiopathic myelofibrosis (CIMF)

    Objective: To study the changes of serum fibrosis markers levels and the pattern of bone marrow scintigraphy and their relationship with clinical stages in patients with chronic idiopathic myelofibrosis (CIMF). Methods: Transforming growth factor-β1 (TGF-β1) and platelet derived growth factor (PDGF) (with ELISA), serum typeIII procollagen (PCIII), type IV collagen (C-IV), and laminin (LN) (with RIA) were detected in 46 with patients with chronic idiopathic myelofibrosis and 34 controls. Bone marrow scintigraphy 99m Tc-sulfur colloid was performed in the 46 CIMF patients. Results: Five fibrosis markers in patients with CIMF were significantly higher than those in controls. There were significantly differences among the levels in different stages, especially with sclerotic stage in CIMF patients. The imaging patterns were classified into three types according to the radio-distribution and activity of bone marrow: 13 cases of increased imaging in 14 patients of cellular stage, 17 cases with creased expansion imaging in 19 patients of collagen fiber stage and 13 cases (100%) with totally depressed imaging in patients of sclerotic stage. Conclusion: As the disease progressed, the serum fibrosis markers levels gradually incroased and the scintigraphy patterns corresponded well to the clinical staging. (authors)

  13. Talking Bones.

    Johnson, Jaclyn; Kassing, Sharon

    2002-01-01

    Describes cooperation with the Saint Louis Zoo to provide opportunities for elementary school students to learn about bones, how animals move, what they eat, and how much they grow. Uses biofacts which include bones, skulls, and other parts to make the laboratory a hands-on experience for students. (YDS)

  14. Bone Markers

    ... bone turnover: C-telopeptide (C-terminal telopeptide of type 1 collagen (CTx)) – a marker for bone resorption. It is ... resorption include: N-telopeptide (N-terminal telopeptide of type 1 collagen (NTx)) – a peptide fragment from the amino terminal ...

  15. Imaging features of hemangioma in the long bone%长骨血管瘤的影像诊断

    彭志刚; 孙英彩; 李晓娜; 吴文娟; 崔建岭; 赵振江

    2011-01-01

    Objective To explore the imaing features of hemangioma in the long bone and improve the diagnostic level of this disease. Methods The X-ray(14 cases), CT(9 cases) and MRI(6 cases)findings of 18 patientswith histologically proven hemangioma in the long bone after surgery were retrospectively reviewed. Results Ten tumors occurred in medullary cavity or bone end(medullary type),6 on the surface of bone (periosteal type) and 3 in cortex (intracortical type). X-ray findings: among 8 cases of medullary type, 3 showed honeycomb appearance, 3 lytic areas with sclerotic borders, one purely osteolyticchanges, and 1 frosted glass; 3 cases of periosteal type showed sclerosis and thickening of the underlying cortex; 3 cases of intracortical type showed well-defined osteolytic foci. CT findings: among 6 cases of medullary type, 5 appeared as expansile lytic lesion with uneven selerotic rim (3 cases)orhoneycomb appearance (2 cases), 1 cribriform appearance in the cortical bone, 2 periostealnew bone formation in vertical radiation pattern; 1 ground-glass appearance; among 2 cases of periosteal typeone showed regular cortical thickening, and the other irregular periosteal proliferation with marrowing of medullarycavity; 1 case of intracorticaltype showed density similar to that of soft tissue, with cortical thickening and expansion . MRI findings: 2 apeared as well-defined lesions with low signal intensity on T1WI and high signal intensity on T2WI; 1 appeared as ill-defined lesion with low to intermediate signal intensity on T1 WI and T2 WI. One showed breakthrogh of cortex and formation of soft tissue mass with low signal intensity on T1 WI and high signal on T2WI. Two showed thickening of periosteumwith intermediate signal intensity in one of them and very low signal intensity in the other. Two showed abnormal signal intensity in surrounding muscles, which was high on T2 WI and intermediate on T1 WI. Conclusions The soap-bubble or honeycomb appearance is the typical radiographic

  16. Bone densitometry

    Ravn, Pernille; Alexandersen, P; Møllgaard, A

    1999-01-01

    The bisphosphonates have been introduced as alternatives to hormone replacement therapy (HRT) for the treatment and prevention of postmenopausal osteoporosis. The expected increasing application in at clinical practice demands cost-effective and easily handled methods to monitor the effect on bone....... The weak response at the distal forearm during antiresorptive treatment has restricted the use of bone densitometry at this region. We describe a new model for bone densitometry at the distal forearm, by which the response obtained is comparable to the response in other regions where bone densitometry...... is much more expensive and technically complicated. By computerized iteration of single X-ray absorptiometry forearm scans we defined a region with 65% trabecular bone. The region was analyzed in randomized, double-masked, placebo- controlled trials: a 2-year trial with alendronate (n = 69), a 1-year...

  17. Acetabular rim and surface segmentation for hip surgery planning and dysplasia evaluation

    Tan, Sovira; Yao, Jianhua; Yao, Lawrence; Summers, Ronald M.; Ward, Michael M.

    2008-03-01

    Knowledge of the acetabular rim and surface can be invaluable for hip surgery planning and dysplasia evaluation. The acetabular rim can also be used as a landmark for registration purposes. At the present time acetabular features are mostly extracted manually at great cost of time and human labor. Using a recent level set algorithm that can evolve on the surface of a 3D object represented by a triangular mesh we automatically extracted rims and surfaces of acetabulae. The level set is guided by curvature features on the mesh. It can segment portions of a surface that are bounded by a line of extremal curvature (ridgeline or crestline). The rim of the acetabulum is such an extremal curvature line. Our material consists of eight hemi-pelvis surfaces. The algorithm is initiated by putting a small circle (level set seed) at the center of the acetabular surface. Because this surface distinctively has the form of a cup we were able to use the Shape Index feature to automatically extract an approximate center. The circle then expands and deforms so as to take the shape of the acetabular rim. The results were visually inspected. Only minor errors were detected. The algorithm also proved to be robust. Seed placement was satisfactory for the eight hemi-pelvis surfaces without changing any parameters. For the level set evolution we were able to use a single set of parameters for seven out of eight surfaces.

  18. PREDICTION OF LOADING DISTRIBUTION AND HYDRODYNAMIC MEASUREMENTS FOR PROPELLER BLADES IN A RIM DRIVEN THRUSTER

    CAO Qing-ming; HONG Fang-wen; TANG Deng-hai; HU Fang-lin; LU Lin-zhang

    2012-01-01

    This article presents an approach which employs a commercial Reynolds-Averaged Navier-Stokes (RANS) solver to predict the steady wake field and loading distributions for a rim driven thruster.Four different cases of propeller blades are chosen to be calculated with the presented method.The propeller blade radial circulation and chordwise circulation density distributions are analyzed.The maximum radial circulation is found at the blade tip,which is different from conventional shaft drven propeller.The numerical results indicate that there is no tip leakage vortex in rim driven propulors.But there exist the tip joint vortex and the root region vortex.Bollard characteristics are calculated by taking rim surface effect into account.From the predicted results the second case in this paper is selected as the final one to perform hydrodynamic experiment.The calculation results with empirical rim surface corrections are compared with the measurement.It shows that the developed numerical method can well predict hydrodynamic performances of the rim driven thruster.

  19. Experimentally Produced Spinel Rims on Ca-Al-Rich Inclusion Bulk Compositions

    Paque, Julie M.; Le, L.; Lofgren, G. E.

    1998-01-01

    Most Ca-Al-rich inclusions (CAls) from Allende are surrounded by a series of mineralogically distinct rim layers. Proposed modes of formation for these layers include flash heating, evaporation, and condensation. The innermost of these rim layers is generally spinel (SP), in some cases intergrown with perovskite (PV), and commonly containing varying amounts of secondary iron increasing towards the edge of the CAI. The SP or SP+PV rim is not always contiguous with the other rim layers, indicating that it is probably the result of a separate event. We have produced continuous SP rims on synthetic analogs representing Type A/B1, average Type B, and Type B2 bulk compositions by reheating a solid glass experimental charge to subliquidus crystallization temperatures. This experimental result is consistent with the formation of chondrules; and CAIs by more than one sequence of heating and cooling. Previous work indicated that prior crystallization events produced observable effects in the texture and chemistry of the final run product. Information on the nature of the heating/cooling cycles experienced by CAls and chondrules is important in modeling the environment of their formation. Additional information is contained in the original extended abstract.

  20. Heat/Mass Transfer Measurement on The Tip Surface Of Rotor Blade With Squlear Rim

    Park, Jun Su; Lee, Dong Hyun; Lee, Woo Jin; Cho, Hyung Hee; Rhee, Dong-Ho; Kang, Shin-Hyung

    2010-06-01

    The present study investigates local heat/mass transfer characteristics on blade tip surface with squealer rim. A linear cascade experimental setup consists of three large scale airfoils was used. The axial chord length and turning angle of test blade are 237 mm and 126°, respectively. Heat/mass transfer coefficients were measured with three different rim heights (3%, 6% and 9% of axial chord length) and fixed tip clearance (2% of axial chord length). Main flow Reynolds number based on axial chord length is 1.5×105. Naphthalene sublimation method is used to measure the detailed mass transfer coefficient on the blade tip surface. The heat/mass transfer results show that as the rim height increases, the peak values on the upstream region of the tip surface decreases and moves to the suction side rim. At the downstream region of the tip surface, the pitch-wise averaged heat/mass transfer coefficients increases as the rim height increases.

  1. Seamless Rim-Functionalization of h-BN with Silica-Experiment and Theoretical Modeling.

    Furlotti, Michele; Caputo, Riccarda; Krumeich, Frank; Nesper, Reinhard

    2015-05-18

    Boron nitride contains six-ring layers, which are isostructural to graphene, and it exhibits similar extraordinary mechanical strength. Unlike graphene, hexagonal boron nitride (h-BN) is an insulator and has some polar features that make it a perfect material for those applications graphene is not suitable for, for example, purely ionic conductors, insulating membranes, transparent coatings, composite ceramics, high oxidation resistance materials. We report here a selective rim-functionalization of h-BN with SiO2 by using the Stöber process. A closed, protruding ring of SiO2 is formed covering all edges perpendicular to the [001] zones of the h-BN stacks and thus shield the most reactive centers of BN layers. SEM and HAADF-STEM images, X-ray spectroscopy, and atomic force microscopy confirm the rim-functionalization by SiO2 . XRD demonstrates the absence of any intercalation phenomenon of BN and reveals the glassy nature of the SiO2 rims. Selected variations of synthesis and theoretical modeling both confirm that rim activation by water prior to the Stöber condensation is crucial. First-principles calculations also confirm that dangling bonds of clean BN edges merge to give interlayer bonds that make further functionalization much more difficult. The reported reaction pathway should allow for other new functionalizations of pure BN and of the rimmed SiO2 /h-BN composites. PMID:25873400

  2. Cracking of an Aircraft Wheel Rim Made From Al-Alloy 2014-T6

    G. Kosec

    2010-10-01

    Full Text Available Generally failures of different aircraft components and parts are revealed and examined by the use of non-destructive examination methods. In further detailed explanation and interpretation of failures optical and scanning electron microscopy are used. This paper deals with a problem of a crack on aircraft wheel rim made from aluminium alloy 2014-T6.The crack was observed during regular control by the maintenance unit for non-destructive examination of the Slovenian air carrier Adria Airways. The crack on the rim of an aircraft wheel investigated was a typical fatigue crack. At same time a numerous pits were found which served as stress concentrations on the rim surface.

  3. Heat transfer coefficient of wheel rim of large capacity steam turbines

    Jinyuan SHI; Zhicheng DENG; Yu YANG; Ganwen JUN

    2008-01-01

    A way of calculating the overall equivalent heat transfer coefficient of wheel rims of large capacity steam turbines is presented. The method and formula to calculate the mean forced convection heat-transfer coefficient of the surface of the blade and for the bottom wall of the blade passage, are introduced. The heat transmission from the blade to the rim was simplified by analogy to heat transmission in the fins. A fin heat transfer model was then used to calculate the equivalent heat transfer coefficient of the blade passage. The overall equivalent heat transfer coefficient of the wheel rim was then calculated using a cylindrical surface model. A practical calculation example was presented. The pro-posed method helps determine the heat transfer bound-ary conditions in finite element analyses of temperature and thermal stress fields of steam turbine rotors.

  4. Opportunity, Geologic and Structural Context of Aqueous Alteration in Noachian Outcrops, Marathon Valley and Rim and Endeavour Crater

    Crumpler, L. S.; Arvidson, R. E.; Mittlefehldt, D. W.; Jolliff, B. L.; Farrand, W. H.; Fox, V.; Golombek, M. P.

    2016-01-01

    In its 12th year of exploration and 1600 sols since arrival at the rim of the 22 km-diameter Noachian Endeavour impact crater, Mars Exploration Rover Opportunity traversed from the summit of the western rim segment "Cape Tribulation" to "Marathon Valley", a shallow trough dissecting the rim and the site of strong orbital detection of smectites. In situ analysis of the exposures within Marathon Valley is establishing some of the geologic and geochemical controls on the aqueous alteration responsible for smectite detection known to occur in crater rims throughout Noachian terrains of Mars.

  5. Flows in a rotor disk rim seal with a nonaxisymmetric mainstream; Hitaisho jikuryuchu no rotor disk rim seal nai no nagare

    Sano, M. [Shizuoka Institute of Science and Technology, Shizuoka (Japan); Hasegawa, Y.; Kikuyama, K. [Nagoya University, Nagoya (Japan); Daikoku, T. [Nippon Steel Corp., Tokyo (Japan)

    2000-05-25

    An experimental investigation of fluid flows in a model of gas-turbine rotor disk rim seal has been carried out. The effects of outward throughflow and rotor speed were examined on the distributions of static pressure as well as velocity inside the rim seal when a mainstream was made nonaxisymmetric by stationary vanes. Measurements were made at the mainflow axial Reynolds number of 8.0 x 10{sup 4}. As a radially outward flow is forced to be generated on the rotor by centrifugal force, a radially inward flow due to a mainstream ingestion is originated on the stator of the rim seal when the throughflow rate is decreased beyond the critical value. Once the ingestion occurs locally, the static pressure is increased remarkably just behind the stationary vanes resulting in the circumferentially non-uniform distribution. But the ingestion is suppressed with the increasing throughflow rate and the static pressure distribution tends to be uniform. The critical throughflow rate was found to be about 0.8 times of the outward flow rate caused by a free disk. (author)

  6. RIM as the data base management system for a material properties data base

    Karr, P. H.; Wilson, D. J.

    1984-01-01

    Relational Information Management (RIM) was selected as the data base management system for a prototype engineering materials data base. The data base provides a central repository for engineering material properties data, which facilitates their control. Numerous RIM capabilities are exploited to satisfy prototype data base requirements. Numerical, text, tabular, and graphical data and references are being stored for five material types. Data retrieval will be accomplished both interactively and through a FORTRAN interface. The experience gained in creating and exercising the prototype will be used in specifying requirements for a production system.

  7. Rim intratorácico ectópico Thoracic ectopic kidney

    Claudinei Leôncio Beraldo; Eugênio Fernandes de Magalhães; Demétrius Tierno Martins; Douglas Silva Coutinho; Lívia Silva Tiburzio; Mário Ribeiro Neto

    2005-01-01

    O rim ectópico intratorácico é uma anomalia rara. De todas as ectopias renais é a mais rara (p = 0,005%). Relata-se um caso de ectopia renal intratorácica em um homem negro de 83 anos, que procurou atendimento médico com quadro clínico compatível com enfisema pulmonar. Foi solicitado radiograma de tórax, que evidenciou uma massa, diagnosticada por tomografia computadorizada como ectopia renal. A maioria dos casos de rim torácico aparece como uma tumoração intratorácica encontrada em radiogram...

  8. Bone Tumor

    ... the knee in either the femur (thigh) or tibia (shinbone). Other common locations include the hip and ... bone that is weakened by a tumor to fracture, or break. This may be severely painful. Occasionally, ...

  9. Your Bones

    ... a fall! If you play sports like football, soccer, lacrosse, or ice hockey, always wear all the ... to strengthen your bones is through exercise like running, jumping, dancing, and playing sports. Take these steps ...

  10. Amphibole reaction rims as a record of pre-eruptive magmatic heating: An experimental approach

    De Angelis, S. H.; Larsen, J.; Coombs, M.; Dunn, A.; Hayden, L.

    2015-09-01

    Magmatic minerals record the pre-eruptive timescales of magma ascent and mixing in crustal reservoirs and conduits. Investigations of the mineral records of magmatic processes are fundamental to our understanding of what controls eruption style, as ascent rates and magma mixing processes are well known to control and/or trigger potentially hazardous explosive eruptions. Thus, amphibole reaction rims are often used to infer pre-eruptive magma dynamics, and in particular to estimate magma ascent rates. However, while several experimental studies have investigated amphibole destabilization during decompression, only two investigated thermal destabilization relevant to magma mixing processes. This study examines amphibole decomposition experimentally through isobaric heating of magnesio-hornblende phenocrysts within a natural high-silica andesite glass. The experiments first equilibrated for 24 h at 870 °C and 140 MPa at H2O-saturated conditions and ƒO2 ∼ Re-ReO prior to rapid heating to 880, 900, or 920 °C and hold times of 3-48 h. At 920 °C, rim thicknesses increased from 17 μm after 3 h, to 55 μm after 12 h, and became pseudomorphs after longer durations. At 900 °C, rim thicknesses increased from 7 μm after 3 h, to 80 μm after 24 h, to pseudomorphs after longer durations. At 880 °C, rim thicknesses increased from 7 μm after 3 h, to 18 μm after 36 h, to pseudomorphs after 48 h. Reaction rim microlites vary from 5-16 μm in size, with no systematic relationship between crystal size and the duration or magnitude of heating. Time-averaged rim microlite growth rates decrease steadily with increasing experimental duration (from 3.97 ×10-7 mms-1 to 3.1 to 3.5 ×10-8 mms-1). Time-averaged microlite nucleation rates also decrease with increasing experimental duration (from 1.2 ×103mm-3s-1 to 5.3 mm-3 s-1). There is no systematic relationship between time-averaged growth or nucleation rates and the magnitude of the heating step. Ortho- and clinopyroxene

  11. 30 CFR 56.19074 - Riding the bail, rim, bonnet, or crosshead.

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Riding the bail, rim, bonnet, or crosshead. 56.19074 Section 56.19074 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL...

  12. 30 CFR 57.19074 - Riding the bail, rim, bonnet, or crosshead.

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Riding the bail, rim, bonnet, or crosshead. 57.19074 Section 57.19074 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND...

  13. Significance of fracture rim zone heterogeneity for tracer transport in crystalline rock

    Cvetkovic, V.

    2010-03-01

    Conducting fractures of crystalline rock are typically altered over long periods of time. The fracture rim zone, a result of these alterations, will as a rule have different physical and chemical properties from the unaltered ("fresh") rock, depending on various microscopic and macroscopic factors of the alterations. In this paper, we study the impact of rim zone heterogeneity, exemplified by a decreasing porosity trend as inferred from the Äspö Hard Rock Laboratory site (Sweden), on short- and long-term tracer transport. Our main finding is that this particular rim zone structure will have a dominant effect on transport of moderately to strongly sorbing tracers on experimental time scales and a notable effect on application time scales. The findings of this work lend further support to the interpretation of the relatively strong retention reported by Cvetkovic et al. The fracture rim zone porosity structure may provide an additional safety margin for sorbing radionuclides in crystalline rock at sites where fracture alteration is prevalent.

  14. Incident laser modulation of a repaired damage site with a rim in fused silica rear subsurface

    Li Li; Xiang Xia; Zu Xiao-Tao; Yuan Xiao-Dong; He Shao-Bo; Jiang Xiao-Dong; Zheng Wan-Guo

    2012-01-01

    Local CO2 laser treatment has proved to be an effective method to prevent the 351-nm laser-induced damage sitesin a fused silica surface from exponentially growing,which is responsible for limiting the lifetime of optics in high fluence laser systems.However,the CO2 laser induced ablation crater is often surrounded by a raised rim at the edge,which can also result in the intensification of transmitted ultraviolet light that may damage the downstream optics.In this work,the three-dimensional finite-difference time-domain method is developed to simulate the distribution of electrical field intensity in the vicinity of the CO2 laser mitigated damage site located in the exit subsurface of fused silica.The simulated results show that the repaired damage sites with raised rims cause more notable modulation to the incident laser than those without rims.Specifically,we present a theoretical model of using dimpled patterning to control the rim structure around the edge of repaired damage sites to avoid damage to downstream optics.The calculated results accord well with previous experimental results and the underlying physical mechanism is analysed in detail.

  15. Resource-saving technology for producing blanks wheel rims with the unit longitudinal-transverse cutting

    Кононенко, Д. Ю.; Павлюк, А. В.; Антоненко, А. В.; Разиньков, Н. А.

    2013-01-01

    Analysis of the grade and dimensional range of original metal used in the manufacture of wheels andrims was carried out. Defined are the parameters and characteristics of rolls cutting, required for selecting aplant unit. One of the ways of increasing economical efficiency of wheel rims production was investigated,in order to optimize blanks manufacturing technology with considerations for the production program.

  16. Effect of centrifugal load on crack path in thin-rimmed and webbed gears

    F. Curà

    2015-10-01

    Full Text Available Thin rimmed and webbed gears are used in particular applications to reduce systems weight. This kind of gears need an accurate and fail safe design. As a matter of fact, a possible failure, due to bending fatigue, consists in crack nucleation and consequent growth, in particular in the tooth root zone. These cracks may propagate through the tooth or through the rim. Crack propagation direction is basically influenced by the wheel geometry parameters, above all the rim thickness. Studies available in literature emphasize three ranges for the backup ratio values, involving different behaviors. These ranges are related to the crack propagation paths; respectively through the tooth, through the rim and in an unforeseeable way. This last uncertainty zone depends on other parameters, related to both geometry and loading conditions. In this work the effect of wheel speed related to the bending load has been investigated. The investigation has been carried out by means of numerical models involving both 2D finite element and extended finite element models (XFEM. Results shows that both crack initiation point and crack propagation path are strongly influenced by centrifugal load; this effect is mainly evident in the uncertainty zone of the backup ratio

  17. 29 CFR 1910.177 - Servicing multi-piece and single piece rim wheels.

    2010-07-01

    ... Standards, 29 CFR part 1926; the Agriculture Standards, 29 CFR part 1928; the Shipyard Standards, 29 CFR part 1915; or the Longshoring Standards, 29 CFR part 1918. (3) All provisions of this section apply to... 29 Labor 5 2010-07-01 2010-07-01 false Servicing multi-piece and single piece rim wheels....

  18. A Unified Framework for Producing CAI Melting, Wark-Lovering Rims and Bowl-Shaped CAIs

    Liffman, Kurt; Paterson, David A

    2016-01-01

    Calcium Aluminium Inclusions (CAIs) formed in the Solar System, some 4,567 million years ago. CAIs are almost always surrounded by Wark-Lovering Rims (WLRs), which are a sequence of thin, mono/bi-mineralic layers of refractory minerals, with a total thickness in the range of 1 to 100 microns. Recently, some CAIs have been found that have tektite-like bowl-shapes. To form such shapes, the CAI must have travelled through a rarefied gas at hypersonic speeds. We show how CAIs may have been ejected from the inner solar accretion disc via the centrifugal interaction between the solar magnetosphere and the inner disc rim. They subsequently punched through the hot, inner disc rim wall at hypersonic speeds. This re-entry heating partially or completely evaporated the CAIs. Such evaporation could have significantly increased the metal abundances of the inner disc rim. High speed movement through the inner disc produced WLRs. To match the observed thickness of WLRs required metal abundances at the inner disc wall that a...

  19. Opportunities for Partnership in the Pacific Rim: Reflections on a Visit to Vietnam.

    Sykes, Abel B., Jr.

    Community colleges are poised to play a vital role in Vietnam and other Pacific Rim nations currently seeking to develop their business sectors and economies. Projects and partnerships with U.S. community colleges are currently in progress in India, Malaysia, China, Japan, Taiwan, and Korea. In addition, the Vietnamese Ministry of Education and…

  20. 76 FR 69720 - NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    2011-11-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market... in the above-referenced proceeding of NaturEner Rim Rock Wind Energy, LLC's application for...

  1. Stereological evolution of the rim structure in PWR-fuels at prolonged irradiation: Dependencies with burn-up and temperature

    The stereology of the rim-structure was studied for PWR-fuels up to the ninth irradiation cycle, achieving maximum local burn-ups of 240 GWd/tM and beyond. At intermediate radial positions (0.55 0 c = 0.29. Rim-cavities are expected to remain closed at least up to this limit

  2. A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity.

    Read, Timothy; Richmond, Phillip A; Dowell, Robin D

    2016-01-01

    Most genetic variants associated with disease occur within regulatory regions of the genome, underscoring the importance of defining the mechanisms underlying differences in regulation of gene expression between individuals. We discovered a pair of co-regulated, divergently oriented transcripts, AQY2 and ncFRE6, that are expressed in one strain of Saccharomyces cerevisiae, ∑1278b, but not in another, S288c. By combining classical genetics techniques with high-throughput sequencing, we identified a trans-acting single nucleotide polymorphism within the transcription factor RIM101 that causes the background-dependent expression of both transcripts. Subsequent RNA-seq experiments revealed that RIM101 regulates many more targets in S288c than in ∑1278b and that deletion of RIM101 in both backgrounds abrogates the majority of differential expression between the strains. Strikingly, only three transcripts undergo a significant change in expression after swapping RIM101 alleles between backgrounds, implying that the differences in the RIM101 allele lead to a remarkably focused transcriptional response. However, hundreds of RIM101-dependent targets undergo a subtle but consistent shift in expression in the S288c RIM101-swapped strain, but not its ∑1278b counterpart. We conclude that ∑1278b may harbor a variant(s) that buffers against widespread transcriptional dysregulation upon introduction of a non-native RIM101 allele, emphasizing the importance of accounting for genetic background when assessing the impact of a regulatory variant. PMID:26751950

  3. The kinetics of dolomite reaction rim growth under isostatic and non-isostatic pressure conditions

    Helpa, V.; Rybacki, E.; Morales, L. G.; Abart, R.; Dresen, G. H.

    2013-12-01

    During burial and exhumation, rocks are simultaneously exposed to metamorphic reactions and tectonic stresses. Therefore, the reaction rate of newly formed minerals may depend on chemical and mechanical driving forces. Here, we investigate the reaction kinetics of dolomite (CaMg[CO3]2) rim growth by solid-state reactions experiments on oriented calcite (CaCO3) and magnesite (MgCO3) single crystals under isostatic and non-isostatic pressure conditions. Cylindrical samples of 3-5 mm length and 7 mm diameter were drilled and polished perpendicular to the rhombohedral cleavage planes of natural clear crystals. The tests were performed using a Paterson-type deformation apparatus at P = 400 MPa confining pressure, temperatures, T, between 750 and 850°C, and reaction durations, t, of 2 - 146 h to calculate the kinetic parameters of dolomite rim growth under isostatic stress conditions. For non-isostatic reaction experiments we applied in addition differential stresses, σ, up to 40 MPa perpendicular to the contact interface at T = 750°C for 4 - 171 h duration, initiating minor inelastic deformation of calcite. The thickness of the resulting dolomite reaction rims increases linearly with the square root of time, indicating a diffusion-controlled reaction. The rims consist of two different textural domains. Granular dolomite grains (≈ 2 -5 μm grain size) form next to calcite and elongated palisade-shaped grains (1-6 μm diameter) grow perpendicular to the magnesite interface. Texture measurements with the electron backscatter diffraction technique indicate that the orientations of dolomite grains are mainly influenced by the orientation of the calcite educt crystal, in particular in the granular rim. To some extent, the texture of dolomite palisades is also influenced by the orientation of magnesite. The thickness of the two individual layers increases with temperature. At 400 MPa isostatic pressure, T = 750°C and t = 29 hours, a 5 μm thick granular dolomite layer

  4. Calculation of ejecta thickness and structural uplift for Lunar and Martian complex crater rims.

    Krüger, Tim; Sturm, Sebastian; Kenkmann, Thomas

    2014-05-01

    Crater rims of simple and complex craters have an elevation that is formed during the excavation stage of crater formation. For simple crater rims it is believed that the elevation is due to the sum of two equal parts, the thickness of the most proximal impact ejecta blanket (overturned flap) plus the thickness that results from plastic deformation including injection [1, 2, 3]. We intend to measure and quantify the kinematics of mass movements, especially concerning the question why complex impact craters have elevated crater rims like simple craters and precisely constrain the ejecta thickness and structural uplift of Lunar and Martian crater rims to understand what the main contributor to the elevated rim is [4]. We investigated a pristine 16 km-diameter unnamed Martian complex crater (21.52°N, 184.35°) and the lunar complex craters Bessel (21.8°N, 17.9°E) 16 km in diameter and Euler (23.3°N, 29.2°W) 28 km in diameter [5, 6]. In the crater walls of these craters we found columnar lavas on Mars and basaltic layering on the Moon. We used the uppermost layers of these exposed outcrops along the crater wall to determine the dip of the target rocks (Mars) and to distinguish between the bedrock and the overlying ejecta. We precisely measured the structural uplift and ejecta thickness of these complex craters. The unnamed crater on Mars has a mean rim height of 375.75 m, with a structural uplift of 233.88 m (57.44%), exposed as columnar lavas and the superposing ejecta has a height of 141.87 m (43.56%). For the Lunar complex crater Euler the mean total rim height is 790 ± 100 m, with a minimal structural uplift of 475 ± 100 m (60 ± 10 %), exposed as basaltic layers [e.g., 7, 8] and a maximum ejecta thickness of 315 ± 100 m (40 ± 10%). The Lunar complex crater Bessel has a total rim height of 430 ± 15 m , with a minimal structural uplift of 290 ± 15 m (67 ± 3 %), exposed as basaltic layers and a maximum ejecta thickness of 140 ± 115 m (33 ± 3%). For the

  5. A magnetic resonance imaging study on changes in rat mandibular bone marrow and pulp tissue after high-dose irradiation

    Lee, Wan; Lee, Byung Do [Dept. of Oral and Maxillofacial Radiology and Wonkwang Dental Research Institute, College of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Lee, Kang Kyoo [Dept. of Radiation Oncology, School of Medicine, Wonkwang University, Iksan (Korea, Republic of); Koh, Kwang Joon [Dept. of Oral and Maxillofacial Radiology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju (Korea, Republic of)

    2014-03-15

    This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow.

  6. A magnetic resonance imaging study on changes in rat mandibular bone marrow and pulp tissue after high-dose irradiation

    This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow.

  7. Iron-Manganese Redox Reactions in Endeavour Crater Rim Apron Rocks

    Ming, D. W.; Mittlefehldt, D. W.; Gellert, R.; Peretyazhko, T.; Clark, B. C.; Morris, R. V.; Yen, A. S.; Arvidson, R. E.; Crumpler, L. S.; Farrand, W. H.; Grant, J. A., III; Jolliff, B. L.; Parker, T. J.; Schroder, C.

    2015-01-01

    The Mars Exploration Rover Opportunity has been exploring Noachian age rocks and outcrops on the rim of the 22 km diameter Endeavour crater since August 2011. The Cape York area is a low-lying rim of Endeavour that contains 3 distinct lithologies: 1) the stratigraphically lowest Matijevic fm of pre-impact lithology, 2) Shoemaker fm of impact breccias, and 3) the stratigraphically highest rim lithology Grasberg fm of post-impact sediments that drape the lower slopes of the rim. The sulfate-rich sediment of the Burns fm lies unconformably over the Grasberg fm. Ca-sulfate veins were discovered in Grasberg fm sediments; the sulfates precipitated from aqueous fluids flowing upward through these materials. Opportunity investigated the chemistry and morphology of outcrops in the Matijevic fm that have Fe(sup 3+)-rich smectite detected by orbital signatures returned by CRISM on MRO. Matijevic fm also contains "boxwork" fractures with chemistry consistent with an Al-rich smectite and veins that appear to be rich in Ca-sulfate. More recently on Cape Tribulation, Opportunity has characterized two S-, Mg- and Mn-rich rich rocks overturned and fractured by the rover's wheels on Cook Haven. Those rocks have been dubbed "Pinnacle Island" and "Stuart Island" and will be referred to as the "Island" rocks. The objectives of this study are to characterize the Fe and Mn contents in the Cape York materials, including the two Island rocks, and to provide a model for Mn mobilization and precipitation. Detailed geochemistry of Endeavour rim rocks is presented in a companion paper. Geochemical trends and elemental associations were obtained from data returned by the Alpha Particle X-ray Spectrometer (APXS) on Opportunity.

  8. Bone densitometer

    In an x-ray bone densitometer, special calibration techniques are employed to accommodate variations. In one aspect, a bone-like calibration material is interposed and the system determines the calibration data from rays passing only through flesh. In another aspect, a rotating device carries the calibration material through the beam. The specific densitometer shown uses an x-ray tube operated at two different voltages to generate a pencil beam, the energy levels of the x-ray photons being a function of the voltage applied. An integrating detector is timed to integrate the detected signal of the patient-attenuated beam over each pulse, the signals are converted to digital values and a digital computer converts the set of values produced by the raster scan into a representation of the bone density of the patient. Multiple reference detectors with differing absorbers are used by the system to continuously correct for variation in voltage and current of the x-ray tube. Calibration is accomplished by the digital computer on the basis of passing the pencil beam through known bone-representing substance as the densitometer scans portions of the patient having bone and adjacent portions having only flesh. A set of detected signals affected by the calibration substance in regions having only flesh is compared by the computer with a set of detected signals unaffected by the calibration material

  9. Case report 391: Postradiation necrosis of bone (femur) with no evidence of tumour

    Datz, F.L.; Manaster, B.J.

    1986-10-01

    The case has been presented of a 21-year-old man who had been treated for Ewing tumor of the femur with local radiation and chemotherapy ten years previously. Significant increased uptake on the angiogram, blood pool studies and delayed imaging phases of the radionuclide scan was observed. This activity had increased dramatically from the bone scan obtained four years previously. Plain roentgenograms showed a mixed sclerotic and lytic lesion in the femur compatible with radionecrosis, recurrent Ewing tumor or radiation-induced osteosarcoma. Based on the findings of the bone scan a tumor was diagnosed and the patient underwent open biopsy. However, radiation osteonecrosis only was present; recurrent Ewing tumor or osteosarcoma was not observed. It may thus be stated that radiation can cause significant increase in uptake on serial bone scans even many years following radiation therapy. These features may simulate recurrent tumor or osteosarcoma. Thus, radionuclide bone scans, even many years after irradiation therapy, will not reliably differentiate between radiation-induced osteosarcoma, recurrent tumor or radiation osteonecrosis in patients who have been treated previously with radiation.

  10. Characterizing Pyroxene Reaction Space in Calcium-Aluminum Rich Inclusions: Oxidation During CAI Rim Formation

    Dyl, K. A.; Young, E. D.

    2009-12-01

    We define the reaction space that controls changes in pyroxene composition in CAIs and Wark-Lovering (WL) rims in an oxidizing solar nebula. Ti-rich pyroxenes in CAIs record a sub-solar oxygen fugacity (Ti3+/Ti4+~1.5). WL rim pyroxenes in the CAI Leoville 144A have a distinctly lower oxidation state.This difference supports WL rim condensation in an environment of increasing O2(g) and Mg(g) (Simon et al. 2005). We used the following phase components to identify four linearly independent reactions (Thompson 1982): diopside, CaTs (Al2Mg-1Si-1), T3 (Ti3+AlMg-1Si-1), T4 (Ti4+Al2Mg-1Si-2), En (MgCa-1), perovskite, O(g), Mg(g), SiO(g), and Ca(g). Compositional variation in this system is dominated by two reactions. The first is oxidation of Ti3+ via reaction with O and Mg in the gas phase: 1.5 O(g) + Mg(g) → ¼ Di + [Ti4+Mg3/4Ti3+-1Ca-1/4Si-1/2] (1). Pyroxene is produced and En is introduced. The second reaction (2) is perovskite formation. It is observed in the WL rim of Leoville 144A, and experiments confirm that an elevated Ti component converts pyroxene to perovskite(Gupta et al. 1973). MgCa-1 is the third linearly independent reaction (3). They combine to give: ½ Di + x Ca(g)→ x Mg(g)+ Pv + [Mg1/2-xSiTi4+-1Ca-1/2+x](2,3). Unlike (1), pyroxene is consumed in this reaction. The parameter x defines the extent of Mg-Ca exchange. When x > 0.5, WL rim formation occurs in an environment where Mg is volatile and Ca condenses. The reaction space defined by reactions (1) and (2,3) describes the transition from CAI interior to WL rims. WL rim pyroxene Ti contents, [CaTs], and Ca < 1 pfu are all explained in this space. The fourth linearly independent reaction is SiO(g):1/8 Di + ¼ Mg(g)→ ¾ SiO(g) + [Mg3/8Ca1/8Ti4+Ti3+-1Si-1/2](4). Silica reduction forms Ti4+, releasing SiO(g). (4) does not describe the oxidation of Ti3+ in WL rim pyroxene, but (1) - (4) results in En formation directly from the gas phase. This may explain WL rim analyses that have Si contents in excess

  11. Bone lesion biopsy

    Bone biopsy; Biopsy - bone ... needle is gently pushed and twisted into the bone. Once the sample is obtained, the needle is ... sample is sent to a lab for examination. Bone biopsy may also be done under general anesthesia ...

  12. What Is Bone?

    ... by your browser. Home Bone Basics What Is Bone? Publication available in: PDF (57 KB) Related Resources ... Men, and Osteoporosis Osteoporosis Prevention For Your Information Bone Remodeling Throughout life, bone is constantly renewed through ...

  13. Calcium and bones

    Bone strength and calcium ... calcium (as well as phosphorus) to make healthy bones. Bones are the main storage site of calcium in ... your body does not absorb enough calcium, your bones can get weak or will not grow properly. ...

  14. Facts about Broken Bones

    ... White House Lunch Recipes The Facts About Broken Bones KidsHealth > For Kids > The Facts About Broken Bones ... through the skin . continue What Happens When a Bone Breaks? It hurts to break a bone! It's ...

  15. Bone biopsy (image)

    A bone biopsy is performed by making a small incision into the skin. A biopsy needle retrieves a sample of bone and it ... examination. The most common reasons for bone lesion biopsy are to distinguish between benign and malignant bone ...

  16. Bone lesion biopsy

    Bone biopsy; Biopsy - bone ... is sent to a lab for examination. Bone biopsy may also be done under general anesthesia to ... remove the bone can be done if the biopsy exam shows that there is an abnormal growth ...

  17. Osteoclasts prefer aged bone

    Henriksen, K; Leeming, Diana Julie; Byrjalsen, I;

    2007-01-01

    We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of...... aged bones....

  18. Rim versus Non-Rim States in the Arctic Region: Prospects for a Zero-Sum Game or a Win-Win One?

    Ana-Maria Ghimiş

    2013-09-01

    Full Text Available The present paper aims to develop a critical approach on one of the most urgent energy security challenges: the Arctic region. Until recently, it was considered to be a frozen desert, upon which no one raised any legal demands or interests. The global warming, the technological development and the increased need for energy resources had transformed the frozen High North into a very hot spot, where states like US, Canada, Norway, Denmark or Russia started an energy race that threatens to escalate. The Arctic became a strategic area given its opportunities: besides the energy resources, new commercial routes could become available for a longer period of time. But, due to legal uncertainties, the lack of coherent and direct legal procedures of international law, the Arctic game is an open one, in which any state can intervene and ask for a solution that is suitable for its interests. This aspect complicates even further the already unstable region. Some of the actors see the region as an international area, as a common good, where everyone has the right to explore or exploit, while the rim states see the Arctic in sovereign rights terms. Therefore, the game tends to complicate as non-rim players (the EU, China, Japan, NATO and South Korea want to intervene in the region and try to influence its development.

  19. Space Plasma Ion Processing of the Lunar Soil: Modeling of Radiation-Damaged Rim Widths on Lunar Grains

    Chamberlin, S.; Christoffersen, R.; Keller, L.

    2007-01-01

    Chemically and microstructurally complex altered rims around grains in the finest size fraction (radiation damage and nanoscale deposition of impact or sputter-derived vapors. The formation of the rims is an important part of the space weathering process, and is closely linked to key changes in optical reflectance and other bulk properties of the lunar surface. Recent application of field-emission scanning transmission electron microscope techniques, including energy dispersive X-ray spectral imaging, is making it easier to unravel the "nano-stratigraphy" of grain rims, and to delineate the portions of rims that represent Radiation-Amorphized (RA) host grain from overlying amorphous material that represents vapor/sputter deposits. For the portion of rims formed by host grain amorphization (henceforth called RA rims), we have been investigating the feasibility of using Monte Carlo-type ion-atom collision models, combined with experimental ion irradiation data, to derive predictive numerical models linking the width of RA rims to the grain s integrated solar ion radiation exposure time.

  20. Study of the three-dimensional orientation of the labrum: its relations with the osseous acetabular rim

    Bonneau, Noémie; Bouhallier, July; Baylac, Michel; Tardieu, Christine; Gagey, Olivier

    2012-01-01

    Understanding the three-dimensional orientation of the coxo-femoral joint remains a challenge as an accurate three-dimensional orientation ensure an efficient bipedal gait and posture. The quantification of the orientation of the acetabulum can be performed using the three-dimensional axis perpendicular to the plane that passes along the edge of the acetabular rim. However, the acetabular rim is not regular as an important indentation in the anterior rim was observed. An innovative cadaver study of the labrum was developed to shed light on the proper quantification of the three-dimensional orientation of the acetabulum. Dissections on 17 non-embalmed corpses were performed. Our results suggest that the acetabular rim is better represented by an anterior plane and a posterior plane rather than a single plane along the entire rim as it is currently assumed. The development of the socket from the Y-shaped cartilage was suggested to explain the different orientations in these anterior and posterior planes. The labrum forms a plane that takes an orientation in between the anterior and posterior parts of the acetabular rim, filling up inequalities of the bony rim. The vectors VL, VA2 and VP, representing the three-dimensional orientation of the labrum, the anterior rim and the posterior rim, are situated in a unique plane that appears biomechanically dependent. The three-dimensional orientation of the acetabulum is a fundamental parameter to understand the hip joint mechanism. Important applications for hip surgery and rehabilitation, as well as for physical anthropology, were discussed. PMID:22360458

  1. Asia/Pacific Rim renewable energy market assessments by the State of Hawaii

    The State of Hawaii has begun to encourage its economic growth and diversification by increasing the export of U.S. energy, environment, ocean, and information technologies. Hawaii's Strategic Technology Market Assessment and Development (STMAD) program promotes the transfer of U.S. technology into Asia and the Pacific Rim, locations having phenomenal growth potential and vast technological infrastructure demands. The STMAD program is managed by the State's Department of Business, Economic Development and Tourism (DBEDT). Under the auspices of STMAD, the Hawaii Natural Energy Institute (HNEI) of the University of Hawaii is assessing biomass energy resources of Asian and Pacific Rim countries to identify and investigate sustainable energy markets. This paper reviews the STMAD program and reports findings of renewable energy assessment performed by HNEI and DBEDT. (author)

  2. How a Surface Nanodroplet Sits on the Rim of a Microcap.

    Peng, Shuhua; Dević, Ivan; Tan, Huanshu; Lohse, Detlef; Zhang, Xuehua

    2016-06-14

    The location and morphology of femtoliter nanodroplets that nucleate and grow on a microcap-decorated substrate in contact with a liquid phase were investigated. We experimentally examined four different wetting combinations of the flat area and the microcaps. The results show that depending on the relative wettability, the droplets sit either on the plain surface or on the top of the microcap or on the rim of the microcap. The contact angle and, for the last case, the radial positions of the nanodroplets relative to the microcap center were characterized, in reasonable agreement with our theoretical analysis, which is based on an interfacial energy minimization argument. However, the experimental data show considerable scatter around the theoretical equilibrium curves, reflecting pinning and thus nonequilibrium effects. We also provide the theoretical phase diagram in parameter space of the contact angles, revealing under which conditions the nanodroplet will nucleate on the rim of the microcap. PMID:27183892

  3. Possible rim crest deposits in cores 12027 and 15008 - Some interpretations and problems for future research

    Nagle, J. S.

    1980-01-01

    Light colored coarse grained soils in the upper parts of cores 12027 and 15008 have a chaotic fabric and abundant bedrock-derived rock fragments. They overlie dark colored, fine grained soils with horizontal fabric and abundant regolith-derived rock fragments. The light colored soils are interpreted to be rim crest deposits associated with the craters seen in the lunar surface sampling photographs. The coarse size, poor sorting and chaotic fabric are believed to have originated by the violent mixing processes which are expected with ejecta deposition. The increase in bedrock-derived particles within the light colored soil can be explained by ejecta from craters that penetrated through or deep into the regolith. The dark soils are believed to predate the craters. Distribution of rock fragments in the material interpreted as rim crest ejecta does not fit a simple model of overturned stratigraphy.

  4. Raman spectroscopic characterization of the core-rim structure in reaction bonded boron carbide ceramics

    Raman spectroscopy was used to characterize the microstructure of reaction bonded boron carbide ceramics. Compositional and structural gradation in the silicon-doped boron carbide phase (rim), which develops around the parent boron carbide region (core) due to the reaction between silicon and boron carbide, was evaluated using changes in Raman peak position and intensity. Peak shifting and intensity variation from the core to the rim region was attributed to changes in the boron carbide crystal structure based on experimental Raman observations and ab initio calculations reported in literature. The results were consistent with compositional analysis determined by energy dispersive spectroscopy. The Raman analysis revealed the substitution of silicon atoms first into the linear 3-atom chain, and then into icosahedral units of the boron carbide structure. Thus, micro-Raman spectroscopy provided a non-destructive means of identifying the preferential positions of Si atoms in the boron carbide lattice

  5. Raman spectroscopic characterization of the core-rim structure in reaction bonded boron carbide ceramics

    Jannotti, Phillip; Subhash, Ghatu; Zheng, James Q.; Halls, Virginia; Karandikar, Prashant G.; Salamone, S.; Aghajanian, Michael K.

    2015-01-01

    Raman spectroscopy was used to characterize the microstructure of reaction bonded boron carbide ceramics. Compositional and structural gradation in the silicon-doped boron carbide phase (rim), which develops around the parent boron carbide region (core) due to the reaction between silicon and boron carbide, was evaluated using changes in Raman peak position and intensity. Peak shifting and intensity variation from the core to the rim region was attributed to changes in the boron carbide crystal structure based on experimental Raman observations and ab initio calculations reported in literature. The results were consistent with compositional analysis determined by energy dispersive spectroscopy. The Raman analysis revealed the substitution of silicon atoms first into the linear 3-atom chain, and then into icosahedral units of the boron carbide structure. Thus, micro-Raman spectroscopy provided a non-destructive means of identifying the preferential positions of Si atoms in the boron carbide lattice.

  6. Raman spectroscopic characterization of the core-rim structure in reaction bonded boron carbide ceramics

    Jannotti, Phillip; Subhash, Ghatu, E-mail: subhash@ufl.edu [Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611 (United States); Zheng, James Q.; Halls, Virginia [Program Executive Office—Soldier Protection and Individual Equipment, US Army, Fort Belvoir, Virginia 22060 (United States); Karandikar, Prashant G.; Salamone, S.; Aghajanian, Michael K. [M-Cubed Technologies, Inc., Newark, Delaware 19711 (United States)

    2015-01-26

    Raman spectroscopy was used to characterize the microstructure of reaction bonded boron carbide ceramics. Compositional and structural gradation in the silicon-doped boron carbide phase (rim), which develops around the parent boron carbide region (core) due to the reaction between silicon and boron carbide, was evaluated using changes in Raman peak position and intensity. Peak shifting and intensity variation from the core to the rim region was attributed to changes in the boron carbide crystal structure based on experimental Raman observations and ab initio calculations reported in literature. The results were consistent with compositional analysis determined by energy dispersive spectroscopy. The Raman analysis revealed the substitution of silicon atoms first into the linear 3-atom chain, and then into icosahedral units of the boron carbide structure. Thus, micro-Raman spectroscopy provided a non-destructive means of identifying the preferential positions of Si atoms in the boron carbide lattice.

  7. A New Mechanism of Formation of the Silver—Rim Structure on Primary Gold Grains

    陆建军; 王汝成; 等

    2000-01-01

    Gold minerals in the Baochun skarn-type gold deposit are Au-Ag allogy with Ag contents within the range of 15-35.5wt% and the inerals vary from 5μm to 50μm in size.As viewed from the electron microprobe images,most gold grains show silver rims with a high Ag content as compared with the core,ranging generally from 2 to 3μm in width.From dynamic calculations based on the mass action and mass balance constratints on the crystallization of native gold,it is considered that the enrichment of silver in the rim of gold minerals in due to gradual enrichment of silver in the ore-forming solutions with its evolution from the early to the late metallogenic stage.

  8. Distribution of skeletal muscle involvement in distal myopathy with rimmed vacuoles

    Distribution of skeletal muscle involvement was studied clinically and by computed tomography (CT) in 6 cases (including 5 sporadic cases) with rimmed vacuolar distal myopathy. Although a predilection for the extensors in the lower leg was noted as stressed so far, there were certain cases without this selectivity. The thigh disclosed a selectivity that the flexors and adductors were severely affected while the m. quadriceps femoris was well preserved. The selectivity in the thigh was still found in the cases without selectivity in the lower leg. The neck flexors were also liable to be involved. In addition, CT revealed no compensatory hypertrophy of the specific muscles which was clearly shown in the thigh of distal muscular dystrophy (Miyoshi). The pattern of skeletal muscle involvement was thought to be a characteristic feature of distal myopathy with rimmed vacuoles. It was visualized very clearly and easily by CT of skeletal muscles although it could be noted to a certain degree by physical examination. (author)

  9. Silicon and oxygen self-diffusion in enstatite polycrystals: the Milke et al. (2001) rim growth experiments revisited

    Abart, R.; K. Kunze; R. Milke; R. Sperb; Wilhelm Heinrich;  

    2004-01-01

    Milke et al. (Contrib Mineral Petrol 142: 15-26, 2001) studied the diffusion of Si, Mg and O in synthetic polycrystalline enstatite reaction rims. The reaction rims were grown at 1000°C and 1 GPa at the contacts between forsterite grains with normal isotopic compositions and a quartz matrix extremely enriched in 18O and 29Si. The enstatite reaction rim grew from the original quartz-forsterite interface in both directions producing an inner portion, which replaced forsterite and an outer porti...

  10. Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases

    Akira Toriihara

    2015-07-01

    Full Text Available Temporal bone chondroblastoma is an extremely rare benign bone tumor. We encountered two cases showing similar imaging findings on computed tomography (CT, magnetic resonance imaging (MRI, and dual-time-point 18F-fluorodeoxyglucose (18F-FDG positron emission tomography (PET/CT. In both cases, CT images revealed temporal bone defects and sclerotic changes around the tumor. Most parts of the tumor showed low signal intensity on T2- weighted MRI images and non-uniform enhancement on gadolinium contrast-enhanced T1-weighted images. No increase in signal intensity was noted in diffusion-weighted images. Dual-time-point PET/CT showed markedly elevated 18F-FDG uptake, which increased from the early to delayed phase. Nevertheless, immunohistochemical analysis of the resected tumor tissue revealed weak expression of glucose transporter-1 and hexokinase II in both tumors. Temporal bone tumors, showing markedly elevated 18F-FDG uptake, which increases from the early to delayed phase on PET/CT images, may be diagnosed as malignant bone tumors. Therefore, the differential diagnosis should include chondroblastoma in combination with its characteristic findings on CT and MRI.

  11. Mineral resources of the Massacre Rim Wilderness Study Area, Washoe County, Nevada

    The Massacre Rim Wilderness Study Area encompasses 23,260 acres in Northwest Nevada. There is moderate mineral resource potential for gold, silve, and mercury in hydrothermal deposits in the eastern part of the study area. There is moderate mineral resource potential for uranium throughout the study area. There is no potential for oil and gas in the study area. The potential for geothermal resources is unknown

  12. Investigations on the performances of the electrical generator of a rim-driven marine current turbine”

    Drouen, Laurent; Charpentier, Jean-Frederic; SEMAIL, Eric; Clenet, Stéphane

    2008-01-01

    In this paper, the electrical generator of a rim-driven horizontal-axis current turbine is modeled in detail. Its main characteristics and performances are evaluated (efficiency, mass, cost, etc). This generator is of permanent magnet direct-driven synchronous type and is connected to a variable speed power electronics drive. It is then compared to a more traditional technology (a pod generator) in terms of mass and cost for a common set of specification. In addition, due to the specific geo...

  13. 78 FR 15920 - Federal Motor Vehicle Safety Standards; Tire Selection and Rims

    2013-03-13

    ...This document proposes to amend Federal Motor Vehicle Safety Standard (FMVSS) No. 110 to make it clear that special trailer (ST) tires are permitted to be installed on new trailers with a gross vehicle weight rating (GVWR) of 4,536 kg (10,000 lbs.) or less. It also proposes to exclude these trailers from a vehicle testing requirement that a tire must be retained on its rim when subjected to a......

  14. View of rim of South Ray crater on traverse up Stone Mountain during EVA

    1972-01-01

    A view of the rim of South Ray crater photographed with a 500mm lens from Station no.4 -- the highest point on the traverse up Stone Mountain -- during the second Apollo 16 extravehicular activity (EVA-2) at the Descartes landing site. South Ray crater was a 'fresh' source of angular ejecta in the Lunar Module-Apollo Lunar Surface Experiments Package area and for samples at Station No.8.

  15. Training the next generation of global health experts: experiences and recommendations from Pacific Rim universities

    Withers, Mellissa; Press, David; Wipfli, Heather; McCool, Judith; Chan, Chang-Chuan; Jimba, Masamine; Tremewan, Christopher; Samet, Jonathan

    2016-01-01

    Background Finding solutions to global health problems will require a highly-trained, inter-disciplinary workforce. Global health education and research can potentially have long-range impact in addressing the global burden of disease and protecting and improving the health of the global population. Methods We conducted an online survey of twelve higher education institutions in the Pacific Rim that spanned the period 2005–2011. Program administrators provided data on program concentrations, ...

  16. Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes

    Hammel, N; Belghith, A; Bowd, C; Medeiros, FA; Sharpsten, L; Mendoza, N; Tatham, AJ; Khachatryan, N.; Liebmann, JM; Girkin, CA; Weinreb, RN; Zangwill, LM

    2016-01-01

    To characterize the rate and pattern of age-related and glaucomatous neuroretinal rim area changes in subjects of African and European descent.Prospective longitudinal study.Two hundred ninety-six eyes of 157 healthy subjects (88 patients of African descent and 69 of European descent) and 73 progressing glaucoma eyes of 67 subjects (24 patients of African descent and 43 of European descent) from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study...

  17. Cracking of an Aircraft Wheel Rim Made From Al-Alloy 2014-T6

    G. Kosec; Kovačič, G.; J. Hodolič; Kosec, B.

    2010-01-01

    Generally failures of different aircraft components and parts are revealed and examined by the use of non-destructive examination methods. In further detailed explanation and interpretation of failures optical and scanning electron microscopy are used. This paper deals with a problem of a crack on aircraft wheel rim made from aluminium alloy 2014-T6.The crack was observed during regular control by the maintenance unit for non-destructive examination of the Slovenian air carrier Adria Airways....

  18. Microstructure, Chemistry, and Origin of Grain Rims on ilmenite from the Lunar Soil Finest Fraction

    Christoffersen, Roy; Keller, Lindsay P.; McKay, David S.

    1996-01-01

    Analytical transmission electron microscope (TEM) observations reveal that ilmenite grains sampled from the sub-10 micron size fraction of Apollo 11 (10084) and Apollo 16 (61221, 67701) soils have rims 10-300 nm thick that are chemically and microstructurally distinct from the host ilmenite. The rims have a thin outer sublayer 10-50 nm thick that contains the ilmenite-incompatible elements Si, Al, Ca and S. This overlies a relatively thicker (50-250 nm) inner sublayer of nanocrystalline Ti-oxide precipitates in a matrix of single-crystal ilmenite that is structurally continuous with the underlying host grain. Microstructural information, as well as data from x-ray spectrometry (EDS) and electron energy loss spectrometry (EELS) analysis of the inner sublayer, suggest that both the inner and outer sublayer assemblages are reduced and that the inner layer is depleted in Fe relative to the underlying ilmenite. The chemistry of the outer sublayer suggests that it is a surface deposit of sputtered or impact-vaporized components from the bulk lunar soil. The inner sublayer is part of the original host grain that has been physically and chemically processed, but not amorphized, by solar ion irradiation and possibly some subsolidus heating. The fact that the deposited outer sublayer is consistently much thinner than the radiation-altered inner sublayer indicates that only a minor fraction of the total rim volume is a product of vapor or sputter deposition. This finding is in contrast to recent descriptions of thick deposited layers on one-third of regolith silicate grains and indicates that ilmenite and silicate rims as a group are different in the fraction of deposited material that they contain.

  19. RIMS International Conference : Mathematical Challenges in a New Phase of Materials Science

    Kotani, Motoko

    2016-01-01

    This volume comprises eight papers delivered at the RIMS International Conference "Mathematical Challenges in a New Phase of Materials Science", Kyoto, August 4–8, 2014. The contributions address subjects in defect dynamics, negatively curved carbon crystal, topological analysis of di-block copolymers, persistence modules, and fracture dynamics. These papers highlight the strong interaction between mathematics and materials science and also reflect the activity of WPI-AIMR at Tohoku University, in which collaborations between mathematicians and experimentalists are actively ongoing.

  20. Tip gap flow characteristics in a turbine cascade equipped with pressure-side partial squealer rims

    Highlights: • The tip gap flow over pressure-side (PS) squealer tips is investigated. • A schematic tip gap flow model for the PS squealer tip is suggested. • The PS squealer tip has lower aerodynamic loss than the plane tip. - Abstract: Tip gap flow characteristics and aerodynamic loss generations in a turbine cascade equipped with pressure-side partial squealer rims have been investigated with the variation of its rim height-to-span ratio (hp/s) for a tip gap height of h/s = 1.36%. The results show that the tip gap flow is characterized not only by the incoming leakage flow over the pressure-side squealer rim but also by the upstream flow intrusion behind the rim. The incoming leakage flow tends to decelerate through the divergent tip gap flow channel and can hardly reach the blade suction side upstream of the mid-chord, due to the interaction with the upstream flow intrusion as well as due to the flow deceleration. A tip gap flow model has been proposed for hp/s = 3.75%, and the effect of hp/s on the tip surface flow is discussed in detail. With increasing hp/s, the total-pressure loss coefficient mass-averaged all over the present measurement plane decreases steeply, has a minimum value for hp/s = 1.88%, and then increases gradually. Its maximum reduction with respect to the plane tip result is evaluated to be 11.6%, which is found not better than that in the cavity squealer tip case

  1. Radiolucent rim as a possible diagnostic aid for differentiating jaw lesions.

    Mortazavi, Hamed; Baharvand, Maryam; Rahmani, Somayeh; Jafari, Soudeh; Parvaei, Parvin

    2015-12-01

    In this study, we formulate a new proposal that complements previous classifications in order to assist dental practitioners in performing a differential diagnosis based on patients' radiographs. We used general search engines and specialized databases such as Google Scholar, PubMed, PubMed Central, MedLine Plus, Science Direct, Scopus, and well-recognized textbooks to find relevant studies by using keywords such as "jaw disease," "jaw lesions," "radiolucent rim," "radiolucent border," and "radiolucent halo." More than 200 articles were found, of which 70 were broadly relevant to the topic. We ultimately included 50 articles that were closely related to the topic of interest. When the relevant data were compiled, the following eight lesions were identified as having a radiolucent rim: periapical cemento-osseous dysplasia, focal cemento-osseous dysplasia, florid cemento-osseous dysplasia, cemento-ossifying fibroma, osteoid osteoma, osteoblastoma, odontoma, and cementoblastoma. We propose a novel subcategory, jaw lesions with a radiolucent rim, which includes eight entities. The implementation of this new category can help improve the diagnoses that dental practitioners make based on patients' radiographs. PMID:26730374

  2. Influence of stress and strain on dolomite rim growth: a comparative study

    Helpa, V.; Rybacki, E.; Morales, L. F. G.; Dresen, G.

    2015-08-01

    Triaxial compression and torsion experiments were performed to investigate the influence of non-isostatic stress and strain on dolomite reaction rim growth using orientated natural calcite and magnesite single crystals at a temperature of 750 °C, 400 MPa confining pressure, stresses between 7 and 38 MPa, and test durations up to 171 h. Reaction products were composed of a polycrystalline magnesio-calcite layer, palisade-shaped dolomite, and granular dolomite grains. In all experiments, inelastic deformation was partitioned into calcite and reaction products, while magnesite remained undeformed. Calcite deformed by twinning and dislocation creep, where the activation of additional glide systems at high stress allowed high strain. Depending on grain size, magnesio-calcite deformed by diffusion creep and/or grain boundary sliding, twinning, and dislocation creep. Dolomite deformed mainly by diffusion creep, assisted by enhanced dislocation activity allowing Ca enrichment in the granular rim. A weak crystallographic preferred orientation of the reaction products was observed. In triaxial compression, dolomite rim growth was diffusion-controlled and showed no influence of axial stresses up to 38 MPa on the reaction kinetics. At high strain (>0.1), the magnesio-calcite layer is wider suggesting faster growth kinetics. This may be related to additional diffusion pathways provided by enhanced dislocation activity. At very high strain (>0.3-0.6), twisted samples showed a gradual decrease in layer thickness of dolomite and magnesio-calcite with increasing strain (-rate).

  3. The significance of evaluating the craniolateral acetabular rim for hip dysplasia

    The weight-bearing part of the canine hip is its dorsocraniolateral portion. On the radiograph the configuration of the craniolateral acetabular rim is important for evaluation of hip dysplasia. Changes in formation of this area should be differentiated from artefacts due to malpositioning. When the pelvis is tilted dorsally, the cranial acetabular rim is superimposed on the cranioventral acetabular contour and the acetabular roof. The craniolateral contour then seems to be missing. The contours of a ventrally tilted pelvis do not overlap, but it is difficult to discern the craniolateral rim. The reference points for Norberg-Olsson's measurements are difficult to choose in both cases and the angles may vary up to 10 degrees. A symmetrically positioned pelvis shows one point of reference for Norberg-Olsson's measurement where the cranial acetabular contour, the cranioventral margin and the acetabular roof intersect. Therefore poor positioning of the pelvis for radiographic evaluation of hip dysplasia should be avoided when using Norberg-Olsson's measurements

  4. Energy indicators series: analyzing the energy-related evidence of economic transition in the Pacific Rim

    In recent years, much attention has been focused upon the Asian Pacific countries as constituting an economic 'miracle' over the last two decades. Economic growth in the Pacific Rim has been higher than in any other area of the world. The rapid industrialization process and its impact on the economies of these countries, at both macro and micro levels, are discussed widely in the economic literature. Of particular interest are the fundamental structural changes these countries have experienced in their transition to industrialized economies. This instalment of the annual 'Energy indicators' series concentrates on Pacific Rim countries, namely Hong Kong, the Philippines, Singapore, South Korea, Taiwan and Thailand. Similar to other experiences, rapid economic growth in these countries has been accompanied by 'spectacular' growth in demand for energy. Therefore, this year's paper not only underlines certain trends in these six energy markets but also attempts to test the phenomenon 'threshold country', i.e., shifting from the developing to the industrialized world by using common indicators and methodologies. The analysis starts with a comparison of energy intensities. Section 2 provides an overview of the socio-economic and energy indicators of the Pacific Rim countries. Section 3 introduces a standard econometric model on the most dynamic consuming sector, namely transport. Section 4 presents the projections of consumption in this sector and discusses policy issues. Some concluding remarks in Section 6 complete the paper. (author)

  5. Evidence for an Ancient Buried Landscape on the NW Rim of Hellas Basin, Mars

    Crown, David A.; Bleamaster, Leslie F., III; Mest, Scott C.; Mustard, John F.; Vincendon, Mathieu

    2010-01-01

    Hellas basin is the largest (2000+ km across) well-preserved impact structure on Mars and its deepest depositional sink [e.g., 1]. The Hellas rim and adjacent highlands are of special interest given the possibility of paleolakes on the basin floor [2-4], recent studies of potential localized fluvial/lacustrine systems [2, 5-17], and evidence for phyllosilicates around and within impact craters north of the basin [18-26]. We are producing a 1:1.5M-scale geologic map of eight MTM quadrangles (-25312, -25307, -25302, -25297, -30312, -30307, -30302, -30297) along Hellas NW rim. The map region (22.5-32.5degS, 45- 65degE) includes a transect across the cratered highlands of Terra Sabaea, the degraded NW rim of Hellas, and basin interior deposits of NW Hellas Planitia. No previous mapping studies have focused on this region, although it has been included in earlier global and regional maps [27-29].

  6. Surface dimming by the 2013 Rim Fire simulated by a sectional aerosol model

    Yu, Pengfei; Toon, Owen B.; Bardeen, Charles G.; Bucholtz, Anthony; Rosenlof, Karen H.; Saide, Pablo E.; Da Silva, Arlindo; Ziemba, Luke D.; Thornhill, Kenneth L.; Jimenez, Jose-Luis; Campuzano-Jost, Pedro; Schwarz, Joshua P.; Perring, Anne E.; Froyd, Karl D.; Wagner, N. L.; Mills, Michael J.; Reid, Jeffrey S.

    2016-06-01

    The Rim Fire of 2013, the third largest area burned by fire recorded in California history, is simulated by a climate model coupled with a size-resolved aerosol model. Modeled aerosol mass, number, and particle size distribution are within variability of data obtained from multiple-airborne in situ measurements. Simulations suggest that Rim Fire smoke may block 4-6% of sunlight energy reaching the surface, with a dimming efficiency around 120-150 W m-2 per unit aerosol optical depth in the midvisible at 13:00-15:00 local time. Underestimation of simulated smoke single scattering albedo at midvisible by 0.04 suggests that the model overestimates either the particle size or the absorption due to black carbon. This study shows that exceptional events like the 2013 Rim Fire can be simulated by a climate model with 1° resolution with overall good skill, although that resolution is still not sufficient to resolve the smoke peak near the source region.

  7. Nat'l_Register, ContributingResources, The Rim Trail at Pipe Spring National Monument, Arizona (pisp_qrytrail)

    National Park Service, Department of the Interior — This is an Arc/Info coverage consisting of 4 arcs representing the portion of The Rim Trail at Pipe Spring National Monument, Arizona that occurs within the...

  8. Gaucher disease: MR evaluation of bone marrow features during treatment with enzyme replacement

    Purpose: Enzyme replacement therapy (ERT) arrests and reverses the hematological and visceral symptoms of adult Gaucher disease, the most frequent lysosomal storage disorder. There are only a few studies available evaluating bone disease during ERT. The aim of this study was to investigate the features of bone marrow (bm) by magnetic resonance imaging (MRI) in these patients during ERT. Materials and Methods: MRI was performed prospectively in thirty adult type I Gaucher patients before and during ERT with a mean follow-up of 3 years. Spin-echo sequences (T1/T2) of the lower extremities were obtained and the reconversion (response) or lack of reconversion (non-response) to fatty marrow during treatment was analyzed. The morphological features of bm involvement, a homogeneous or non-homogeneous distribution of bm changes and focal bone lesions surrounded by a rim of reduced signal intensity (SI), were analyzed. Results: Infiltration of bm by Gaucher cells is characterized by a reduction of Sl on both T1- and T2-weighted sequences. Bone marrow responses were seen in 19 patients (63%) during treatment. Focal bone lesions, surrounded by a rim of reduced Sl, did not respond to ERT and correlated with a non-homogenous distribution of bone involvement and splenectomy. (orig.)

  9. Feasibility and Safety of Transthoracic Echocardiography-Guided Transcatheter Closure of Atrial Septal Defects with Deficient Superior-Anterior Rims

    Gui-Shuang Li; Hai-De Li; Jie Yang; Wen-Quan Zhang; Zong-Shen Hou; Qing-Chen Li; Yun Zhang

    2012-01-01

    Although previous studies showed that transthoracic echocardiography (TTE) can be used to guide transcatheter closure of atrial septal defect (ASD), whether TTE can be used to guide transcatheter closure of secundum ASD with a deficient superior-anterior rim is unknown and this critical issue was addressed in the present study. A total of 280 patients with secundum ASD who underwent transcatheter ASD closure were recruited and divided into groups A and B depending on ASD superior-anterior rim...

  10. A Method to Prepare a Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) Graft Using Donor Corneas With Narrow Scleral Rims

    Lin, Tzu-Yu; Hwang, Yih-Shiou; Ma, David Hui-Kang

    2015-01-01

    Abstract Donor corneas with narrow scleral rims are often disqualified for Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK), mainly because of fluid leak and low pressure when they are mounted onto an artificial anterior chamber (AAC). This report describes a novel method to tight-lock a donor cornea with a narrow scleral rim so that microkeratome cutting is possible, allowing a DSAEK procedure to be completed. A 50-year-old male suffering from Epstein–Barr virus (EBV) endothel...

  11. AoRim15 is involved in conidial stress tolerance, conidiation and sclerotia formation in the filamentous fungus Aspergillus oryzae.

    Nakamura, Hidetoshi; Kikuma, Takashi; Jin, Feng Jie; Maruyama, Jun-Ichi; Kitamoto, Katsuhiko

    2016-04-01

    The serine-threonine kinase Rim15p is a master regulator of stress signaling and is required for stress tolerance and sexual sporulation in the yeast Saccharomyces cerevisiae. However, in filamentous fungi that reproduce asexually via conidiation, the physiological function of Rim15p homologs has not been extensively analyzed. Here, we functionally characterized the protein homolog of Rim15p in the filamentous fungus Aspergillus oryzae, by deleting and overexpressing the corresponding Aorim15 gene and examining the role of this protein in stress tolerance and development. Deletion of Aorim15 resulted in an increase in the sensitivity of conidia to oxidative and heat stresses, whereas conidia of the Aorim15 overexpressing strain were more resistant to these stresses. These results indicated that AoRim15 functions in stress tolerance, similar to S. cerevisiae Rim15p. Phenotypic analysis revealed that conidiation was markedly reduced by overexpression of Aorim15 in A. oryzae, and was completely abolished in the deletion strain. In addition, the formation of sclerotia, which is another type of developmental structure in filamentous fungi, was decreased by the deletion of Aorim15, whereas Aorim15 overexpression increased the number of sclerotia. These results indicated that AoRim15 is a positive regulator of sclerotia formation and that overexpression of AoRim15 shifts the developmental balance from conidiation towards sclerotia formation. Collectively, we demonstrated that AoRim15 is involved in the stress tolerance of conidia and differentially regulates between the two developmental fates of conidiation and sclerotia formation. PMID:26467693

  12. Fission gas release behavior in high burnup UO{sub 2} fuels with developed rim-structure

    Une, Katsumi [Global Nuclear Fuel-Japan Co. Led., Oarai, Ibaraki (Japan); Kashibe, Shinji [Nippon Nuclear Fuel Development Co. Ltd., Oarai, Ibaraki (Japan); Hayashi, Kimio [Japan Atomic Energy Research Inst., Tokyo (Japan)

    2002-11-01

    The effect of rim structure formation and external restraint pressure on fission gas release at transient conditions has been examined by using an out-of-pile high pressure heating technique for high burnup UO{sub 2} fuels (60, 74 and 90 GWd/t), which had been irradiated in test reactors. The latter two fuels bore a developed rim structure. The maximum heating temperature was 1500 degC, and the external pressures were independently controlled in the range of 10-150 MPa. The present high burnup fuel data were compared with those of previously studied BWR fuels of 37 and 54 GWd/t with almost no rim structure. The fission gas release and bubble swelling due to the growth of grain boundary bubbles and coarsened rim bubbles were effectively suppressed by the strong restraint pressure of 150 MPa for all the fuels; however the fission gas release remarkably increased for the two high burnup fuels with the developed rim structure, even at the strong restraint conditions. From the stepwise de-pressurization tests at an isothermal condition of 1500degC, the critical external pressure, below which a large burst release due to the rapid growth and interlinkage of the bubbles abruptly begins, was increased from a 40-60 MPa level for the middle burnup fuels to a high level of 120-140 MPa for the rim-structured high burnup fuels. The high potential for transient fission gas release and bubble swelling in the rim-structured fuels was attributed to highly over-pressurized fission gases in the rim bubbles. (author)

  13. Pyogenic osteomyelitis of long bone: MR findings

    To evaluate the usefulness of MR in the osteomyelitis, we reviewed MR examinations of 14 patients with pyogenic osteomyelitis of the long bone. All 14 patients were confirmed to have osteomyelitis either surgically (13/14) or by aspiration (1/14). MRI was performed with 0.5 T (n=8) or 2.0 T (n=6) SE technique, and Gd-DTPA enhanced T1WI was obtained in 10 examinations. Anatomic location of lesions were femur (8/14), tibia (5/14) , and fibula (1/14). The marrow cavity and soft tissue were involved in 13/14, 12/14 respectively. The signals of both intraosseous and extraosseous infected area were iso to low signal intensity to muscles on T1WI and high signal intensity on PDWI and T2WI. Rim or diffuse enhancement of the marrow cavity and soft tissue were seen in all (10/10) case. Sequestra, periosteal reaction, and cortical defect were found in 12/14, 10/14, 9/14. MR provided more accurate and detailed anatomic information including extent of disease and possible activity than bone scintigraphy, CT, or conventional radiography. We conclude that MR might be the choice of modality in the diagnosis of osteomyelitis of the long bone

  14. Evaluation of radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT

    The aim of the study was to retrospectively evaluate radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT and determine their roles on the evaluation of therapy response. We retrospectively evaluated radiographic and metabolic characteristics of bone metastases in 30 patients who were referred for the evaluation of response to systemic therapy with 18FDG-PET/CT. All patients underwent integrated 18FDG-PET/CT before and after treatment. The baseline radiographic patterns of the target lesions in responders group were lytic, sclerotic, mixed and CT negative; after treatment the radiographic patterns of all target lesions changed to a sclerotic pattern and attenuation increased (p = 0.012) and metabolic activity decreased (p = 0.012). A correlation was found between decreasing metabolic activity and increasing attenuation of the target lesions (r = −0.55) (p = 0.026). However, in nonresponders group, the baseline radiologic patterns of the target lesions were lytic, blastic, mixed and CT negative; after treatment all lytic target lesions remained the same and one CT negative lesion turned to lytic pattern and the attenuation of the target lesions decreased (p ± 0.12) and metabolic activity increased (p = 0.012). A correlation was found between increasing metabolic activity and decreasing attenuation (r = −0.65) (p = 0.032). An exception of this rule was seen in baseline blastic metastases which progressed with increasing in size, metabolic activity and attenuation. This study shows that the metabolic activity of lesions is a more reliable parameter than the radiographic patterns for the evaluation of therapy response

  15. Subperiosteal ganglion associated with Paget's disease of bone

    Tumoral lesions related to Paget's disease may be classified as malignant, benign or pseudotumoral. While sarcomatous degeneration is the most feared complication, awareness of benign and pseudotumoral lesions is essential for assisting in accurate histological interpretation of the biopsy sample, which may avoid unnecessary repeat biopsies. We present the first case of a juxta-articular subperiosteal ganglion associated with Paget's disease, with classic imaging characteristics, especially on CT examination. The well-defined soft tissue mass at the medial aspect of the obturator rim, adjacent to a small fracture in pagetic quadrilateral plate, showed an ossified rim and internal gas lucencies, these being the hallmarks of a juxta-articular subperiosteal ganglion. On MRI, the lesion was of intermediate signal intensity on T1-weighted sequences, increased signal intensity on T2-weighted sequences, with rim enhancement after gadolinium contrast injection and preservation of fatty marrow signal of the underlying pagetic bone. Identification of the entity avoided an unnecessary biopsy or surgical intervention. (orig.)

  16. Bone marrow biopsy

    Biopsy - bone marrow ... A bone marrow biopsy may be done in the health care provider's office or in a hospital. The sample may be taken from the pelvic or breast bone. Sometimes, other areas are used. Marrow is removed ...

  17. Bone marrow aspiration

    ... this page: //medlineplus.gov/ency/article/003658.htm Bone marrow aspiration To use the sharing features on this page, please enable JavaScript. Bone marrow is the soft tissue inside bones that helps ...

  18. Feldspar-fluid interactions in braid microperthites: pleated rims and vein microperthites

    Lee, Martin R.; Waldron, Kim A.; Parsons, I.; Brown, William L.

    Braid microperthitic alkali feldspars in the Klokken, South Greenland and Coldwell, Ontario syenite intrusions have bulk-compositional variations along grain boundaries called pleated rims. These, together with vein microperthites in aplites which cross-cut the syenites, have been investigated by SEM and TEM. We distinguish two main types of pleated rims, ``arched '' and ``parallel-sided '', consisting of alternating Ab- and Or-rich areas on (001), which are 0.5-300 μm in length normal to (010) and 0.2-20 μm in width along (010). The smallest pleats, which occur on intracrystalline boundaries in Klokken feldspars, are fully coherent and composed of low albite and low microcline. Above the heads of some of the coarser pleats, braid microperthite grades into a film crypto- and micro-perthite and antiperthite microtexture called a ``transitional zone'' containing roughly planar lamellae of low albite and tweed orthoclase. During pleat development, local alternating volumes form in which the proportions of the phases differ ( phase separation) and the morphology of the intergrowths changes from braided to straight in response to this change in local bulk composition. Straightening is also accompanied by transformation of low microcline to tweed orthoclase. The coarsest pleats, which occur along grain boundaries in feldspars from the Coldwell syenite, are semi- or in-coherent and have a thick coherent and semicoherent transitional zone. Coarsening of pleats and development of the transitional zone has been facilitated by diffusion of ``water'' into grain interiors. In many cases, pleated rims have suffered deuteric alteration, by dissolution-reprecipitation processes, through the action of a water-rich fluid from the grain boundary, in which tweed orthoclase was transformed into irregular microcline and micropores developed. Vein microperthites in aplites from Klokken, and by extension the vein microperthites almost universal in most alkali granites, are interpreted

  19. Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis

    Bokuda Kota

    2012-11-01

    Full Text Available Abstract Background The autophagic vacuolar myopathies (AVM are a group of inherited myopathies defined by the presence of autophagic vacuoles in pathological muscle specimens. AVM can be categorized into three groups: acid maltase deficiency, myopathies characterized by autophagic vacuoles with unique sarcolemmal features, and rimmed vacuolar myopathies (RVM. While the pathogeneses of these conditions are still being elucidated, some drugs (e.g., chloroquine, its analog, hydroxychloroquine, and colchicine can also cause AVM. Minocycline is a disease-modifying anti-rheumatic drug that may be used in the treatment of rheumatoid arthritis (RA. Here, we describe the first case of minocycline-associated AVM with rimmed vacuole formation. Case presentation A 75-year-old woman suffering from RA has been continuously treated with minocycline (200 mg/day for the past 7 years. During this time, she developed a myopathy that predominantly affected her lower limbs. Histological studies of biopsied muscle revealed scattered atrophic myofibers with rimmed vacuoles that contained pigment granules. Histochemical staining revealed that the pigment comprised both iron and melanin, which is consistent with type II minocycline-induced cutaneous pigmentation. Under electron microscopy, autophagic vacuoles were consistently observed in association with numerous collections of pigment granules. Conclusions This is the first report of minocycline-induced pigmentation in skeletal muscle. The strong association between autophagic vacuoles and the accumulation of minocycline-induced pigments suggest that long-term minocycline treatment induced pigment accumulation, leading to elevation of autophagic activity and RVM. It might also be possible that minocycline directly activated autophagy, as the observed pigments are known to form complexes containing minocycline and/or its metabolites. As long-term minocycline treatment is expected to be used more widely in the future

  20. Study of iocalization rim void%定位孔缘破孔的研究

    林秀鑫; 薛敏芬

    2012-01-01

      主要介绍孔缘破孔(在碱性蚀刻流程中发生的干膜流胶入孔致孔中开路)的影响因素。对定位孔缘破孔的形成机理进行分析及试验模拟,得出定位孔缘破孔的原因为:特殊结构特征板件在贴膜后板件板面局部温度较高,在没有散热完全情况下被收板放置在一起,导致定位区域干膜继续流胶入孔。通过提高贴膜后板件散热效果,最终杜绝定位孔缘破孔的产生。%  This paper mainly introduces the factors of rim void, which is the resist flows into the hole and causes hole-opening in alkaline etching process. The rim void occurs in the same location, which was analyzed through theory and simulated by experiments, and the reason was archived. The temperature of local area with special structural characteristics boards is higher than others’, if the heat dissipation was poor after resist lamination, it will cause the resist flows farer into the hole in this location area. By improving the effect of heat dissipation after resist lamination, the location of the rim void will be eliminated finally.

  1. Inactivated Bone Replantation with Preservation of the Epiphysis in Children with Osteosarcoma- Clinical Report of Two Cases

    YUXiuchun; LIUXiaoping; ZHOUYin; LIKaihua; QUZaiping

    2005-01-01

    Objective: To evaluate the value of inactivated bone replantation with preservation of the epiphysis following the effective chemotherapy in avoiding postoperative discrepancy of the affected limb in children with osteosarcoma. Methods: Two children (aged 5 and 10 years, 1 male and 1 female) with osteosarcoma underwent inactivated bone replantation with preserving epiphysis following chemotherapy (MMIA protocol, including high-dose methotrexate, adriamycin and ifosfamide). After two cycles of preoperative chemotherapy, pain vanished, the local mass shrank and there was no pain on pressing the affected parts. Sera AKP and LDH were reduced to normal levels; marked shrinkage and sclerotic changes and good margin of lesions were seen on plain radiographs and MR images. Two courses of the same protocol as preoperative chemotherapy were administered postoperatively. Results: Postoperative histological examination of the specimens demonstrated absence of vital tumor cells. Incisions healed well and no complications occurred. The replanted inactivated bone healed with host at 6 months after operation.In the two patients, no evidence was seen of metastasis and recurrence and discrepancy of the affected limbs in postoperative 36 and 48 months. Functions of the affected limbs were satisfactory. Conclusion:Inactivated bone replantation with preserving epiphysis was a viable option for osteosarcoma in children.The long-term outcomes remain to be further proven.

  2. Long-term bone tissue reaction to polyethylene oxide/polybutylene terephthalate copolymer (Polyactive) in metacarpophalangeal joint reconstruction.

    Waris, Eero; Ashammakhi, Nureddin; Lehtimäki, Mauri; Tulamo, Riitta-Mari; Törmälä, Pertti; Kellomäki, Minna; Konttinen, Yrjö T

    2008-06-01

    The poly-L/D-lactide 96/4 joint scaffolds are used to engineer fibrous tissue joints in situ for the reconstruction of metacarpophalangeal joints. In this experimental study, a supplementary elastomeric stem made of Polyactive 1000PEO70PBT30 (a segmented block copolymer of polyethylene oxide and polybutylene terephtalate with 70/30 PEO/PBT ratio) was used to anchor the joint scaffold in the arthroplasty space. Eleven resected fifth metacarpophalangeal joints of minipig were reconstructed and evaluated radiologically and histologically for 3 years. Plain joint scaffold and Swanson silicone implant arthroplasties (11 of each) in metacarpophalangeal joints of minipig served as controls. Altogether fore limbs of eighteen minipigs were operated for the study. Deleterious tissue reaction with dramatic signs of osteolysis and inflammatory foreign-body reaction was observed around the Polyactive stems. The mean maximum diameter of the osteolytic stem cavity was statistically wider when compared to the mean maximum diameter of Swanson implant group during the first postoperative year. Numerous osteoclasts were found at the margins of the osteolytic areas. No direct bone contact could be seen. At 1 year osteoblastic regeneration and formation of new trabecular bone followed. Finally the foreign-body reaction settled, but the adjoining bones were at this stage highly sclerotic and composed of coarse trabeculae. In contrary to previous in vivo studies suggesting biocompatibility, osteoconductivity and capability to bond to bone, Polyactive 1000PEO70PBT30 stem in this setting caused massive osteolytic lesions and foreign-body reactions. PMID:18336902

  3. Anorexia Nervosa and Bone

    Misra, Madhusmita; Klibanski, Anne

    2014-01-01

    Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone mass, impaired bone structure and reduced bone strength, all of which contribute to increased fracture risk., Adolescents with AN have decreased rates of bone accrual compared with normal-weight controls, raising addition concerns of suboptimal peak bone mass and future bone health in this age group. Changes in lean mass and compartmental fat depots, hormonal alterations secondary to nutritional factors...

  4. “Walk the Rim, Feel the Bone” Technique in Superior Sulcus Filling

    Yong, Kai-Ling

    2015-01-01

    Summary: Superior sulcus filler injection is a nonsurgical method to rejuvenate the upper face. Blindness and stroke are devastating complications of facial filler injection. This study describes an injection technique that minimizes the risk of blindness and includes a case study demonstrating the cosmetic benefits of this procedure. To avoid retrograde injection of filler embolus into the ophthalmic artery, we advocate a “‘walk the rim, feel the bone” approach. Small boluses of hyaluronic acid filler are given in preperiosteal plane, avoiding the superior orbital foramen. PMID:26894017

  5. Tumor misto do rim com estrutura de Miosarcoma Mipernefroma e blastema renal em individuo adulto

    A. Penna de Azevedo

    1942-01-01

    Full Text Available O A. descreve um caso de turmor misto do rim, em indivíduo do sexo masculino, com 58 anos de idade. A doença teve evolução lenta, somente sendo suspeitada, quando atingiu a fase final. O exame necroscópico revelou a existência de volumoso tumor do rim direito, apresentando forma bosselada, medindo 19 x 10 x 10 cm e pesando 940 g. A massa tumoral destrói quase completamente a estrutura renal, desta pouca restando reconhecivel. Fora do rim, encontra-se tambem tecido blastomatoso no figado, nos gânglios linfáticos mesentéricos, no peritônio e no epiploon. A estrutura do tumor, observada nos cortes histológicos, é variavel conforme o tecido examinado: no rim hipernefroma; fígado, gãnglios linfáticos, nos nódulos do peritônio e do epiploon, sarcoma mioblástico; em alguns gânglios do mesentério, alem da estrutura de sarcoma mioblástico, existe tecido nefrógeno, representado por formações pouco numerosas, constituidas por túbulos epiteliais, reproduzindo a estrutura de túbulo urinífero. casos desta natureza teem sido referidos com particular raridade, muito se aproximando o caso estudado do descrito por CHEVREL-BODIN e MARUELLE.The A. describes a case of mixed tumor of the kidney in a 58-year-old male individual. The disease underwent a slow evolution, only being suspected when it attained its final stage. The post mortem examination revealed the presence of a bulky tumor of the right kidney, of a bosselated surface, measuring 19 x 10 x 10 cms. and 940 grs. in weigtht. The tumoral mass destroys the whole kidney structure, of which but very little of recognizable tissue is left. Outside the kidney, blastomatous tissue is also met with in the liver, mesenteric lymphatic glands, peritoneum and apiploon. The tumor structura observed on histological section, varies in conformity with the tissue examined: hipernephroma in the kidney; myoblastic sarcoma in the liver, lymphatic glands, nodules of the peritoneum and epiploon; in some

  6. Technical Efficiency and Port Competition: Revisiting the Bohai Economic Rim, China

    Grace Wang

    2012-12-01

    Full Text Available The Bohai Economic Rim plays an important role in supporting China’s economic growth. For this research, we selected nine main ports in the region to study whether intra-port competition or corporatization would improve efficiency. Using a panel fixed effect model and stochastic frontier model, we found that the technical efficiency of selected ports is significantly influenced by the time of the initial public offering than by regional competition. The results are supportive and encouraging for policy makers to move toward the decentralized port governance in China.

  7. "To Drink from Places": Uncovering a Rich Way of Life Near the Grand Canyon's North Rim

    Rich, Melinda Snow

    2010-01-01

    The chapters of this thesis focus on the history and stories of the people who built and traveled down the highways--Highway 89A, Highway 89, and Highway 67--that branch out from the junction in front of Jacob Lake Inn, the Bowman/Rich family's 87-year-old lodge. The family's role in building roads, supporting and encouraging the growing tourist industry in Kanab and the North Rim of the Grand Canyon, and the converging effects of these choices have created the unique family culture and contr...

  8. Design optimization of a slotless PM brushless motor with spiral wound laminations for rim driven thrusters

    Sharkh, S.M.; Lai, S. H.

    2009-01-01

    This paper discusses the analysis and design of a very thin slotless PM brushless motor whose stator laminations are manufactured from a single strip of steel that is edge wound into a spiral (like a “Slinky”) and then fitted over the windings that are preformed on the outside surface of a non-conducting former. Analytical and finite element analysis (FEA) are used to determine the constrained optimum dimensions of a motor used to drive a rim driven thruster in which the motor rotor is fitted...

  9. Hand-rim Forces and Gross Mechanical Efficiency at Various Frequencies of Wheelchair Propulsion

    Lenton, J. P.; Van der Woude, L.H.V.; Fowler, N. E.; G. Nicholson; Tolfrey, K.; Goosey-Tolfrey, V. L.

    2013-01-01

    To determine the effects of push frequency changes on force application, fraction of effective force (FEF) and gross efficiency (GE) during hand-rim propulsion. 8 male able-bodied participants performed five 4-min sub-maximal exercise bouts at 1.8 m.s(-1); the freely chosen frequency (FCF), followed by 4 counter-balanced trials at 60, 80, 120 and 140 % FCF. Kinetic data was obtained using a SMART(Wheel), measuring forces and moments. The GE was determined as the ratio of external work done an...

  10. Localized and Areally Extensive Alterations in Marathon Valley, Endeavour Crater Rim, Mars

    Mittlefehldt, David W.; Gellert, Ralf; Van Bommel, Scott; Arvidson, Raymond E.; Clark, Benton C.; Cohen, Barbara A.; Farrand, William H.; Ming, Douglas W.; Schroeder, Christian; Yen, Albert S.; Jolliff, Bradley L.

    2016-01-01

    Mars Exploration Rover Opportunity is exploring the rim of 22 km diameter, Noachian-aged Endeavour crater. Marathon Valley cuts through the central region of the western rim providing a window into the local lower rim stratigraphic record. Spectra from the Compact Reconnaissance Imaging Spectrometer for Mars show evidence for the occurrence of Fe-Mg smectite in this valley, indicating areally extensive and distinct lithologic units and/or styles of aqueous alteration. The Alpha Particle X-ray Spectrometer has determined the compositions of 59 outcrop targets on untreated, brushed and abraded surfaces. Rocks in the Marathon Valley region are soft breccias composed of mm- to cm-sized darker clasts set in a lighter-toned, finegrained matrix. They are basaltic in non-volatile-element composition and compositionally similar to breccias investigated elsewhere on the rim. Alteration styles recorded in the rocks include: (1) Enrichments in Si, Al, Ti and Cr in more reddish-colored rock, consistent with leaching of more soluble cations and/or precipitation of Si +/- Al, Ti, Cr from fluids. Coprecipitation of Ge-rich phases with Si occurred in the western area only; high water:rock is indicated. Pancam multispectral observations indicate higher nanophase ferric oxide contents, but the rocks have lower Fe contents. The highly localized nature of the red zones indicate they cannot be the source of the widespread smectite signature observed from orbit. (2) Outcrops separated by approximately 65 m show common compositional changes between brushed and abraded (approximately 1 mm deep) targets: increases in S and Mg; decreases in Al, Cl and Ca. These changes are likely due to relatively recent, surface-related alteration of valley rocks and formation of surface coatings under low water:rock. (3) One target, from the center of a region of strong CRISM smectite signature, shows modest differences in composition (higher Si, K; lower Mn) compared to most Marathon Valley rocks, while

  11. Paget's sarcoma of bone

    The most sinister complication of Paget's disease is malignant degeneration. The true etiology of Paget's disease remains unproven and unknown. The relative incidence of sarcoma ranges from 0.9% to 20% depending upon the population source. The anatomical distribution of lesions is similar to that of uncomplicated Paget's disease except for the high incidence in the humerus and rare occurrence in the spine. Approximately 50% of the lesions histologically represent osteosarcomas, with fibrosarcoma, fibrous histiocytoma, chondrosarcoma and giant cell tumor rarely occurring. The radiographic presentation is most commonly lytic, but sclerotic and mixed patterns occur. Cortical destruction and soft tissue mass are the cardinal radiographic signs. Malignant periosteal response is seldom found associated with Paget's sarcoma. The most common sites are femur, humerus, pelvis, skull and tibia. The prognosis is fatal at a very rapid rate. There are but a few isolated cases of long-term survival reported. (orig.)

  12. Deflated rims along the Xiangshui River on the Xiliaohe Plain, Northeast China: A case of active fluvial-aeolian interactions

    Han, Guang; Zhang, Guifang; You, Li; Wang, Yong; Yang, Lin; Yang, Ji; Zhou, Liang; Yuan, Minghuan; Zou, Xueyong; Cheng, Hong

    2016-03-01

    Riverine source-bordering sand dunes, as a result of active fluvial-aeolian interactions, are a pronounced feature on the semiarid Xiliaohe Plain, Northeast China. By means of satellite imagery analysis, and both field survey and observation, this paper presents a new type of riverine source-bordering sand dunes - deflated rims, on the downwind margins of the Xiangshui River. They largely result from the deflation of escarpments on the downwind side of valley by local prevailing winds of NW direction, not from the reworking of point bars on floodplain by wind. In general, a rim is primarily composed of three distinct zones: 1) the upwind frontal escarpment zone with variable plan-form shape, gradient and relief, which is formed by either active lateral erosion by river or significant erosion by wind and transient slope runoff; 2) the deflation zone with gentle slopes of 8-18° and small-scale aeolian bedforms, i.e. ripples of fine sand, ridges of coarse sand; and 3) the downwind dynamic deposition zone with distinctive bedforms with variable superficial texture and slip faces. The sand mass on rims derives overwhelmingly from underlying loose late Quaternary sediments, is sufficient and sustainable by successive retreats of the escarpment, and is gradually transported downwind by pulse motions of bedforms, coupled with high wind events. Essentially, deflated rims are a starting point and the incipient phase of mature riverine dunefields. The superimposed bedforms on rims are fundamentally governed by windflow dynamics, sand sediments and antecedent bedform, exhibiting in turn the manner and intensity of rim development. Consequently, the upwind river valley and downwind deflated rim can jointly stimulate marked wave-like motion of both windflow and aeolian bedforms at different scales, especially when high wind events occur. This study sheds some light on the understanding of the origin and development of riverine source-bordering dunefields, and offers new

  13. Bone strength: more than just bone density.

    Ott, Susan M

    2016-01-01

    The following bone density measurements have limited utility in determining bone strength because they do not include bone quality: microarchitecture, mineralization, ability to repair damage, collagen structure, crystal size, or marrow composition. Patients with kidney disease have poor bone quality. Newman et al. now describe beneficial effects with raloxifene in an animal model of progressive kidney disease. These biomechanical measurements will be important in the development of medications to decrease fractures in patients. PMID:26759040

  14. Investigations into the value of bone scintigrams in fracture of the navicular bone. Untersuchungen zur Wertigkeit des Knochenszintigramms bei der Fraktur des Os naviculare

    Schumm, G.

    1985-05-14

    The diagnostic value of bone scintigrams was investigated in a group of 22 patients showing fractured navicular bones and contrasted with that of X-ray pictures and clinical evaluations. The changes revealed by radiology were pseudarthrosis (9 patients), complete fracture (10 patients) as well as cysts and sclerotic processes (3 patients). Eight out of 9 cases of pseudarthrosis, 6 of the 10 complete fractures and 2 of the 3 cysts were confirmed by corresponding pathological changes in the scintigrams. The X-ray pictures and clinical evaluations led to consistent results in 14 patients, conformity of the scintigrams and clinical findings was seen in 17 cases and of the X-ray pictures and scintigrams in 15 cases. The results of the study give evidence of the fact that scintigrams recorded after injection of 99 mTc MDP are primarily suitable to diagnose incipient pathological changes in the tissue adjacent to the fracture. Their use is justified in discrepancies between the clinical and radiological findings or in cases, where conventional X-rays yielded doubtful results as to the therapeutic strategy or incapacitation of the patient. (TRV).

  15. Bone development

    Tatara, M.R.; Tygesen, Malin Plumhoff; Sawa-Wojtanowicz, B.;

    2007-01-01

    The objective of this study was to determine the long-term effect of alpha-ketoglutarate (AKG) administration during early neonatal life on skeletal development and function, with emphasis on bone exposed to regular stress and used to serve for systemic changes monitoring, the rib. Shropshire ram...... at 146 days of life and five left and right ribs (fourth to eighth) were removed for analysis. The influence of AKG on skeletal system development was evaluated in relation to both geometrical and mechanical properties, as well as quantitative computed tomography (QCT). No significant differences between...... has a long-term effect on skeletal development when given early in neonatal life, and that changes in rib properties serve to improve chest mechanics and functioning in young animals. Moreover, neonatal administration of AKG may be considered as an effective factor enhancing proper development...

  16. Exercise, lifestyle, and your bones

    Osteoporosis - exercise; Low bone density - exercise ... Osteoporosis is a disease that causes bones to become brittle and more likely to fracture (break). With osteoporosis, the bones lose density. Bone density is the amount of bone ...

  17. A bright-rimmed cloud sculpted by the H ii region Sh2-48

    Ortega, M E; Giacani, E; Rubio, M; Dubner, G

    2013-01-01

    To characterize a bright-rimmed cloud embedded in the HII region Sh2-48 searching for evidence of triggered star formation. We carried out observations towards a region of 2'x2' centered at RA=18h 22m 11.39s, dec.=-14deg 35m 24.81s (J2000) using the Atacama Submillimeter Telescope Experiment (ASTE; Chile) in the 12CO J=3-2,13CO J=3-2, HCO+ J=4-3, and CS J=7-6 lines with an angular resolution of about 22". We also present radio continuum observations at 5 GHz carried out with the Jansky Very Large Array (JVLA; EEUU) interferometer with a synthetized beam of 7"x5". The analysis of our molecular observations reveals the presence of a relatively dense clump with n(H_2)~3x10^3 cm^-3, located in projection onto the interior of the HII region Sh2-48. The emission distribution of the four observed molecular transitions has, at VLSR~38 kms^-1, morphological anti-correlation with the bright-rimmed cloud as seen in the optical emission. From the new radio continuum observations we identify a thin layer of ionized gas lo...

  18. Structural Effects on the Langmuir Monolayers of Calix[4]arene Induced by Lower Rim Aromatic Substitution

    HE Wei-Jiang; QIU Lin; LI Jun-Bai; ZHANG Yu; GUO Zi-Jian; ZHU Long-Gen

    2006-01-01

    The Langmuir monolayer properties of lower rim aromatically substituted calix[4]arenes, 5,11,17,23-tetra-tertbutyl-25,27-bis(2-naphth-1'-ylacetylaminoethoxy)-26,28-dihydroxylcalix[4]arene (BNAEC), 5,11,17,23-tetra-tertbutyl-25,27-bis(2-benzoylamino ethoxy)-26,28-dihydroxylcalix[4]arene (BBAEC) and 5,11,17,23-tetra-tert-butyl-25,27-bis(2-cinnamoylaminoethoxy)-26,28-dihydroxylcalix[4]arene (BCAEC), have been studied. Film balance measurements and Brewster angle microscopy (BAM) observation demonstrate that all the compounds can form Langmuir monolayers with different molecular limiting areas. BNAEC or BBAEC monolayer is able to form condensed domains during compression, while BCAEC monolayer can never form condensed domain. BNAEC monolayer is more readily to form condensed domain than BBAEC monolayer. Moreover, BNAEC monolayer can form the total condensed phase during compression even when T=28 ℃, while BBAEC monolayer can not when T> 10 ℃. The results imply that different lower rim aromatic substitutions affect essentially the intermolecular interaction and molecular packing in the monolayer at air/water interface.

  19. SURGICAL SITE INFECTIONS: A STUDY OF INCIDENCE, RISK FACTORS & ANTIMICROBIAL SENSITIVITY AT RIMS, KADAPA, A. P.

    Giridhar

    2015-08-01

    Full Text Available S urgical site infection is the most common complication following surgical procedures. The aim of the study is to determine the incidence, associated risk factors and antimicrobial sensitivity pattern at RIMS, KADAPA. MATERIALS AND METHODS: This is a prospective study carried at surgical wards of RIMS KADAPA from Jan. 2015 to June 2015. All the patients were followed for 30 days for development of surgical site infection. Infected cases were identified u sing CDC, criteria. All the data are expressed in percentage. RESULTS : The overall prevalence of surgical site infection is 19%. The incidence was more common in age group above 40 years. The risk factors associated with SSI are long stay in hospital (14% , abdominal surgeries, long duration of surgery, and diabetes. The most common organism isolated is Staphylococcus aureus (30%. CONCLUSION: Surgical site infection is most common following surgery. Significant determinants are long stay in the ward, abdomi nal surgeries, emergency surgeries and diabetes. Effective infection control measures and good regular surveillance will improve the SSI rate to an acceptable level.

  20. The Refined Shock Velocity of the X-Ray Filaments in the RCW 86 Northeast Rim

    Yamaguchi, Hiroya; Castro, Daniel; Williams, Brian J; Lopez, Laura A; Slane, Patrick O; Smith, Randall K; Petre, Robert

    2016-01-01

    A precise measurement of shock velocities is crucial for constraining the mechanism and efficiency of cosmic-ray (CR) acceleration at supernova remnant (SNR) shock fronts. The northeastern rim of the SNR RCW 86 is thought to be a particularly efficient CR acceleration site, owing to the recent result in which an extremely high shock velocity of ~6000 km/s was claimed (Helder et al. 2009). Here we revisit the same SNR rim with the Chandra X-ray Observatory, 11 years after the first observation. This longer baseline than previously available allows us to determine a more accurate proper motion of the nonthermal X-ray filament, revealing a much lower velocity of 3000 \\pm 340 km/s (and even slower at a brighter region). Although the value has dropped to a half of that from the previous X-ray measurement, it is still higher than the mean velocity of the H-alpha filaments in this region (~1200 km/s). This discrepancy implies that the filaments bright in nonthermal X-rays and H-alpha emission trace different velocit...

  1. Definition imaging of an orebody with the radio imaging method (RIM)

    Waste rock dilution is an economic concern in the planning and design of mining methods for mineralized ore zones. Diamond core drilling and mineralogical examination of core are routinely used to determine the general shape of the ore body. Drilling on closer centers enhances the definition of the mineralization and oregrade across the orebody. In a practical sense, drilling time and cost limit definition. Crosshole scanning between drillholes with the radio imaging method (RIM) has been used to map changes in mineralization in the rock mass. The magnitude and phase of the RIM radio wave depend on the electrical conductivity of the rock mass. The conductivity strongly depends on the percent mineralization. Since the attenuation rate and phase constants of the radio wave are proportional to the one half power of conductivity, the measured crosshole radio wave data can be processed in a tomography algorithm to reconstruct images (map the change in conductivity (mineralization)). The tomography image enhances definition in the orebody while reducing the number of drillholes. This paper compares reconstructed images of the radio wave propagation constants to percent mineralization in the ore body

  2. Rim intratorácico ectópico Thoracic ectopic kidney

    Claudinei Leôncio Beraldo

    2005-04-01

    Full Text Available O rim ectópico intratorácico é uma anomalia rara. De todas as ectopias renais é a mais rara (p = 0,005%. Relata-se um caso de ectopia renal intratorácica em um homem negro de 83 anos, que procurou atendimento médico com quadro clínico compatível com enfisema pulmonar. Foi solicitado radiograma de tórax, que evidenciou uma massa, diagnosticada por tomografia computadorizada como ectopia renal. A maioria dos casos de rim torácico aparece como uma tumoração intratorácica encontrada em radiogramas de tórax solicitados por qualquer outra razão alheia à suspeita dessa anomalia, e não necessita de tratamento específico.Thoracic ectopic kidney is a rare anomaly, the rarest of all renal ectopia types (p = 0.005%. Herein, we describe a case of thoracic ectopic kidney in an 83-year-old black man who, upon seeking medical attention, presented a clinical profile consistent with pulmonary emphysema. A chest X-ray was ordered, and the results showed evidence of a mass, which was then diagnosed (through computed tomography as renal ectopia. The majority of thoracic ectopic kidney cases present as an intrathoracic tumor seen on chest X-rays ordered for reasons other than suspicion of this anomaly and do not require special treatment.

  3. Analysis of physical processes affecting restructuring of UO2 fuel in Rim-zone

    The purpose of the presented paper is the analysis of the processes affecting so-called 'rim-zone' formation in UO2 and the development of the model describing isotope content profiles at extended burnup. The influence of rim-zone and extended burnup on fuel temperatures is also considered. A brief review of the worldwide models for fission rate and isotope content profiles at extended burnup is given. In this frame, a new model for for prediction of radial profiles of burnup, fission rate and plutonium isotopes have been developed in the TRINITY (Russia). The results from the comparison of the model predictions with experimental data show that the model has good predictability. A new model describing the conditions of dislocation loop nucleation from interstitial atom clusters on fission spikes is also proposed in this paper. The results of the model show that the fuel grain diameter significantly affects the concentration of point defects and dislocation loops. The paper presents the results from the RTOP code calculations of fuel temperature, taking into account non-uniform fission rate and thermal conductivity degradation as result of burnup increasing

  4. Alumina+Silica+/-Germanium Alteration in Smectite-Bearing Marathon Valley, Endeavour Crater Rim, Mars

    Mittlefehldt, D. W.; Gellert, R.; Van Bommel, S.; Arvidson, R. E.; Clark, B. C.; Ming, D. W.; Schroeder, C.; Yen, A. S.; Fox, V. K.; Farrand, W. H.; Jolliff, B. L.

    2016-01-01

    Mars Exploration Rover Opportunity has been exploring Mars for 12+ years, and is presently investigating the geology of a western rim segment of 22 kilometers diameter, Noachian- aged Endeavour crater. The Alpha Particle X-ray Spectrometer has determined the compositions of a pre-impact lithology, the Matijevic fm., and polymict impact breccias ejected from the crater, the Shoemaker fm. Opportunity is now investigating a region named Marathon Valley that cuts southwest-northeast through the central portion of the rim segment and provides a window into the lower stratigraphic record. (Geographic names used here are informal.) At the head of Marathon Valley, referred to here as Upper Marathon Valley, is a shallow, ovoid depression approximately 25×35 millimeters in size, named Spirit of Saint Louis. Layering inside Spirit of Saint Louis appears continuous with the Upper Marathon Valley rocks outside, indicating they are coeval. Spirit of Saint Louis is partly bounded by approximately 10-20 centimeters wide zone containing reddish altered rocks (red zone). Red zones also form prominent curvilinear features in Marathon Valley. Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) spectra provide evidence for a really extensive Fe-Mg smectite in the Marathon Valley region, indicating distinct styles of aqueous alteration. The CRISM detections of smectites are based on metal-OH absorptions at approximately 2.3 and 2.4 micron that are at least two times the background noise level.

  5. MRI of degenerative bone marrow lesions in experimental osteoarthritis of canine knee joints

    Objective. The objective of this study was to determine the value of MRI in the detection of degenerative bone marrow abnormalities in an animal osteoarthritis model. Design. In 10 dogs with experimentally induced unilateral osteoarthritis of the knee, MRI was performed using two-dimensional spin-echo (2D-SE) and three-dimensional gradient-echo (3D-GE) imaging. Contrast enhanced T1-weighted 2D-SE sequences were also obtained after injection of gadolinium-DTPA. The results were compared with the gross and histopathologic findings and with radiography. Results. Histopathologic specimens revealed 21 osteosclerotic lesions and 5 intraosseous cysts. On 2D-SE images, 24 of 26 lesions were detected, while 21 of 26 lesions were identified on 2D-GE sequences. Radiography, including conventional tomography, demonstrated 9 of 26 lesions. Regardless of the sequence weighting, all osteosclerotic lesions appeared hypointense on MRI. Signal loss in bone sclerosis resulted primarily from the reduction of intact fat marrow, the increased bone density being of secondary importance. Quantitative signal analysis allowed approximate estimation of the grade of sclerosis. On postcontrast images, sclerotic bone remained hypointense, although significant but non-specific enhancement relative to the normal fat marrow was observed. The extent of contrast enhancement did not correlate with the grade of osteosclerosis. All five cysts were readily diagnosed by MRI. Cysts displayed either central or marginal contrast enhancement within their cavities. Conclusions. MRI provides a sensitive method for the diagnosis of osteoarthritic bone abnormalities, allowing their differentiation from most non-degenerative subarticular lesions. (orig.). With 1 tab

  6. Blade rim of the centripetal stage of a turbine, preferably for a high-performance steam turbine

    Gundlach, W.; Porochnicki, J.; Prywer, J.; Karewicz, B.; Potapczyk, A.; Zielenow, K.

    1975-10-23

    The blade rim consists of a series of radial blades and one (on one side) or two (on two sides) rows of axial blades, which each form a unit along with the side covers and the rotor wheel. Such a blade rim changes the radial steam stream-in direction under small energy losses, and transfers the axial steam current with a well-balanced speed field to an axial stage connected in series. The basically better efficiency of a centripetal turbine benefits the efficiency of the axial stage and so the whole turbine. The well-balanced speed field in the current to the first axial stage produces hardly any power which might cause vibrations at the blade rim. This becomes even more efficient through the suppression power on the side cover during blade rim rotation. The efficiency of the first axial stage is increased by at least 5% and the length of the rotors and the housings is shortened by the possible reduction of the number of blade rims.

  7. Bisphosphonate-Related Osteonecrosis of the Jaw Bone: Radiological Pattern and the Potential Role of CBCT in Early Diagnosis

    James Olutayo

    2010-04-01

    Full Text Available Objectives: To systematize the clinico-radiological symptoms and course of bisphosphonate-related osteonecrosis of jaw bone and to evaluate the diagnostic potential of various radiological techniques to detect mild osteonecrosis in each stage of the disease.Material and Methods: The sample consisted of 22 patients previously diagnosed with extraoral malignant disease. Diagnosis was based on a clinical examination in conjunction to digital panoramic radiography and cone beam computed tomography (CBCT. Two dentomaxillofacial radiologists reviewed all images.Results: Twenty patients showed mandibular involvement clinically, while two others had a maxillary involvement. Four stages of the disease were proposed based on the clinico-radiological findings. Subclinical cortical and lamina dura thickening was detected with only three-dimensional CBCT and periapical images, while ulceration and cortical bone thickening was detected only by three-dimensional CBCT. Mixed sclerotic, lytic bone destruction involving alveolar and basal bone with or without encroachment on the mandibular canal, pathological mandibular fractures were detected by two-dimensional panoramic and three-dimensional CBCT images. Other findings are non healing extraction sockets, periapical radiolucencies, osteolysis, sequestra, oroantral fistula, and periosteal new bone formation.Conclusions: The present study showed that bisphosphonate-related osteonecrosis of jaw bone occurs in four distinct clinico-radiological stages. For mild cases, panoramic image diagnosis was much less obvious, whereas cone beam computed tomography was able to fully characterise the bony lesions and describe their extent and involvement of neighbouring structures in all cases. Thus cone beam computed tomography might better contribute to the prevention of bisphosphonate-related osteonecrosis of jaw bone as well to the disease management.

  8. Bone grafting: An overview

    D. O. Joshi

    2010-08-01

    Full Text Available Bone grafting is the process by which bone is transferred from a source (donor to site (recipient. Due to trauma from accidents by speedy vehicles, falling down from height or gunshot injury particularly in human being, acquired or developmental diseases like rickets, congenital defects like abnormal bone development, wearing out because of age and overuse; lead to bone loss and to replace the loss we need the bone grafting. Osteogenesis, osteoinduction, osteoconduction, mechanical supports are the four basic mechanisms of bone graft. Bone graft can be harvested from the iliac crest, proximal tibia, proximal humerus, proximal femur, ribs and sternum. An ideal bone graft material is biologically inert, source of osteogenic, act as a mechanical support, readily available, easily adaptable in terms of size, shape, length and replaced by the host bone. Except blood, bone is grafted with greater frequency. Bone graft indicated for variety of orthopedic abnormalities, comminuted fractures, delayed unions, non-unions, arthrodesis and osteomyelitis. Bone graft can be harvested from the iliac crest, proximal tibia, proximal humerus, proximal femur, ribs and sternum. By adopting different procedure of graft preservation its antigenicity can be minimized. The concept of bone banking for obtaining bone grafts and implants is very useful for clinical application. Absolute stability require for successful incorporation. Ideal bone graft must possess osteogenic, osteoinductive and osteocon-ductive properties. Cancellous bone graft is superior to cortical bone graft. Usually autologous cancellous bone graft are used as fresh grafts where as allografts are employed as an alloimplant. None of the available type of bone grafts possesses all these properties therefore, a single type of graft cannot be recomm-ended for all types of orthopedic abnormalities. Bone grafts and implants can be selected as per clinical problems, the equipments available and preference of

  9. Bone scan in rheumatology

    In this chapter a revision is made concerning different uses of bone scan in rheumatic diseases. These include reflex sympathetic dystrophy, osteomyelitis, spondyloarthropaties, metabolic bone diseases, avascular bone necrosis and bone injuries due to sports. There is as well some comments concerning pediatric pathology and orthopedics. (authors). 19 refs., 9 figs

  10. Bone Marrow Diseases

    Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains stem cells. The stem cells can ... the platelets that help with blood clotting. With bone marrow disease, there are problems with the stem ...

  11. Bone Marrow Transplantation

    Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The ... platelets, which help the blood to clot. A bone marrow transplant is a procedure that replaces a ...

  12. Bone grafts in dentistry

    Prasanna Kumar; Belliappa Vinitha; Ghousia Fathima

    2013-01-01

    Bone grafts are used as a filler and scaffold to facilitate bone formation and promote wound healing. These grafts are bioresorbable and have no antigen-antibody reaction. These bone grafts act as a mineral reservoir which induces new bone formation.

  13. Bone grafts in dentistry

    Prasanna Kumar

    2013-01-01

    Full Text Available Bone grafts are used as a filler and scaffold to facilitate bone formation and promote wound healing. These grafts are bioresorbable and have no antigen-antibody reaction. These bone grafts act as a mineral reservoir which induces new bone formation.

  14. Snf7p, a Component of the ESCRT-III Protein Complex, Is an Upstream Member of the RIM101 Pathway in Candida albicans

    Kullas, Amy L.; Li, Mingchun; Davis, Dana A.

    2004-01-01

    The success of Candida albicans as an opportunistic pathogen is based in part on its ability to adapt to diverse environments. The RIM101 pathway governs adaptation to neutral-alkaline environments and is required for virulence. Analysis of a genomic two-hybrid study conducted with Saccharomyces cerevisiae revealed that components involved in multivesicular bodies (MVB) transport may interact with RIM101 pathway members. Thus, we hypothesized that these proteins may function in the RIM101 pat...

  15. Management of subtrochanteric femur fractures with internal fixation and recombinant human bone morphogenetic protein-7 in a patient with osteopetrosis: a case report

    Golden Robert D

    2010-05-01

    Full Text Available Abstract Introduction Osteopetrosis is a group of conditions characterized by defects in the osteoclastic function of the bone resulting in defective bone resorption. Clinically, the condition is characterized by a dense, sclerotic, deformed bone which, despite an increased density observable by radiography, often results in an increased propensity to fracture and delayed union. Case Presentation We report the case of a 27-year-old Asian man presenting with bilateral subtrochanteric femur fractures. He had a displaced right subtrochanteric femur fracture after a low-energy fall, which was treated surgically. The second fracture that our patient endured was diagnosed as a stress fracture ten weeks later when he complained of pain in the contralateral left thigh. By that time, the right-sided fracture exhibited no radiographic evidence of healing, and when the left-sided stress fracture was being treated surgically, bone grafting with recombinant human bone morphogenetic protein-7 was also performed on the right side. Conclusion While there are no data supporting the use of bone morphogenic proteins in the management of delayed healing in patients with osteopetrosis, no other reliable osteoinductive grafting options are available to treat this condition. Both fractures in our patient healed, but based on the serial radiographic assessment it is uncertain to what degree the recombinant human bone morphogenetic protein-7 may have contributed to the successful outcome. It may have also contributed to the formation of heterotopic bone around the fracture site. Further investigation of the effectiveness and indications of bone morphogenic protein use for the management of delayed fracture healing in patients with osteopetrosis is warranted.

  16. BONE IN OSTEOPETROSIS

    Ramkumar

    2014-04-01

    Full Text Available Osteopetrosis, a generalized developmental bone disease due to genetic disturbances, characterized by failure of bone re sorption and continuous bone formation making the bone hard, dense and brittle. Bones of intramembranous ossification and enchondrial ossification are affected genetically and symmetrically. During the process of disease the excess bone formation obliterates the cranial foramina and presses the optic, auditory and facial nerves resulting in defective vision, impaired hearing and facial paralysis. The bone formation in osteopetrosis affects bone marrow function leading to severe anemia and deficient of blood cells. The bone devoid of blood supply due to compression of blood vessels by excess formation of bone are prone to osteomyelitic changes with suppuration and pathological fracture if exposed to infection. Though the condition is chronic progressive, it produces changes leading to fatal condition, it should be studied thoroughly by everyone and hence this article presents a classical case of osteopetrosis with detailed description and discussion for the benefit of readers

  17. Immediate impact on the rim zone of cement based materials due to chemical attack

    Schwotzer, M., E-mail: matthias.schwotzer@kit.edu [Karlsruhe Institute of Technology (KIT), Institute of Functional Interfaces (IFG), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Scherer, T. [Karlsruhe Institute of Technology (KIT), Institute of Nanotechnology (INT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Gerdes, A. [Karlsruhe Institute of Technology (KIT), Institute of Functional Interfaces (IFG), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); University of Applied Sciences Karlsruhe, Institute for Prevention in Construction, Moltkestr. 30, D-76133 Karlsruhe (Germany)

    2015-01-15

    Cement based materials are in their widespread application fields exposed to various aqueous environments. This can lead to serious chemical changes affecting the durability of the materials. In particular in the context of service life prediction a detailed knowledge of the reaction mechanisms is a necessary base for the evaluation of the aggressivity of an aqueous medium and this is deduced commonly from long term investigations. However, these processes start immediately at the material/water-interface, when a cementitious system comes into contact with an aqueous solution, altering here the chemical composition and microstructure. This rim zone represents the first hurdle that has to be overcome by an attacking aqueous solution. Therefore, the properties of the surface near area should be closely associated with the further course of deterioration processes by reactive transport. In this context short term exposure experiments with hardened cement paste over 4 and 48 h have been carried out with demineralized water, hard tap water and different sulfate solutions. In order to investigate immediate changes in the near-surface region, depth profile cuts have been performed on the cement paste samples by means of focused ion beam preparation techniques. A scanning beam of Gallium ions is applied to cut a sharp edge in the cement paste surface, providing insights into the composition and microstructure of the upper ten to hundred microns. Electron microscopic investigations on such a section of the rim zone, together with surface sensitive X-ray diffraction accompanied by a detailed characterization of the bulk composition confirm that the properties of the material/water interface are of relevance for the durability of cement based systems in contact with aqueous solutions. In this manner, focused ion beam investigations constitute auspicious tools to contribute to a more sophisticated understanding of the reaction mechanisms. - Highlights: • The chemical

  18. Immediate impact on the rim zone of cement based materials due to chemical attack

    Cement based materials are in their widespread application fields exposed to various aqueous environments. This can lead to serious chemical changes affecting the durability of the materials. In particular in the context of service life prediction a detailed knowledge of the reaction mechanisms is a necessary base for the evaluation of the aggressivity of an aqueous medium and this is deduced commonly from long term investigations. However, these processes start immediately at the material/water-interface, when a cementitious system comes into contact with an aqueous solution, altering here the chemical composition and microstructure. This rim zone represents the first hurdle that has to be overcome by an attacking aqueous solution. Therefore, the properties of the surface near area should be closely associated with the further course of deterioration processes by reactive transport. In this context short term exposure experiments with hardened cement paste over 4 and 48 h have been carried out with demineralized water, hard tap water and different sulfate solutions. In order to investigate immediate changes in the near-surface region, depth profile cuts have been performed on the cement paste samples by means of focused ion beam preparation techniques. A scanning beam of Gallium ions is applied to cut a sharp edge in the cement paste surface, providing insights into the composition and microstructure of the upper ten to hundred microns. Electron microscopic investigations on such a section of the rim zone, together with surface sensitive X-ray diffraction accompanied by a detailed characterization of the bulk composition confirm that the properties of the material/water interface are of relevance for the durability of cement based systems in contact with aqueous solutions. In this manner, focused ion beam investigations constitute auspicious tools to contribute to a more sophisticated understanding of the reaction mechanisms. - Highlights: • The chemical

  19. Anorexia nervosa and bone.

    Misra, Madhusmita; Klibanski, Anne

    2014-06-01

    Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone mass, impaired bone structure, and reduced bone strength, all of which contribute to increased fracture risk. Adolescents with AN have decreased rates of bone accrual compared with normal-weight controls, raising additional concerns of suboptimal peak bone mass and future bone health in this age group. Changes in lean mass and compartmental fat depots, and hormonal alterations secondary to nutritional factors contribute to impaired bone metabolism in AN. The best strategy to improve bone density is to regain weight and menstrual function. Oral estrogen-progesterone combinations are not effective in increasing bone density in adults or adolescents with AN, and transdermal testosterone replacement is not effective in increasing bone density in adult women with AN. However, physiological estrogen replacement as transdermal estradiol with cyclic progesterone does increase bone accrual rates in adolescents with AN to approximate that in normal-weight controls, leading to a maintenance of bone density Z-scores. A recent study has shown that risedronate increases bone density at the spine and hip in adult women with AN. However, bisphosphonates should be used with great caution in women of reproductive age, given their long half-life and potential for teratogenicity, and should be considered only in patients with low bone density and clinically significant fractures when non-pharmacological therapies for weight gain are ineffective. Further studies are necessary to determine the best therapeutic strategies for low bone density in AN. PMID:24898127

  20. Anorexia Nervosa and Bone

    Misra, Madhusmita; Klibanski, Anne

    2014-01-01

    Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone mass, impaired bone structure and reduced bone strength, all of which contribute to increased fracture risk., Adolescents with AN have decreased rates of bone accrual compared with normal-weight controls, raising addition concerns of suboptimal peak bone mass and future bone health in this age group. Changes in lean mass and compartmental fat depots, hormonal alterations secondary to nutritional factors contribute to impaired bone metabolism in AN. The best strategy to improve bone density is to regain weight and menstrual function. Oral estrogen-progesterone combinations are not effective in increasing bone density in adults or adolescents with AN, and transdermal testosterone replacement is not effective in increasing bone density in adult women with AN. However, physiologic estrogen replacement as transdermal estradiol with cyclic progesterone does increase bone accrual rates in adolescents with AN to approximate that in normal-weight controls, leading to a maintenance of bone density Z-scores. A recent study has shown that risedronate increases bone density at the spine and hip in adult women with AN. However, bisphosphonates should be used with great caution in women of reproductive age given their long half-life and potential for teratogenicity, and should be considered only in patients with low bone density and clinically significant fractures when non-pharmacological therapies for weight gain are ineffective. Further studies are necessary to determine the best therapeutic strategies for low bone density in AN. PMID:24898127

  1. Physical model development for prediction of rim-layer formation in UO2 fuel

    Results of point defects and gas atom behaviour modelling in UO2 fuel are presented for the temperature conditions for rim-layer formation. The spatial profiles for vacancy and interstitial atom concentrations in the vicinity of the grain boundaries and near edge dislocations are different. In the initial stage of irradiation, the peak of vacancy concentration is near the grain boundary. During long irradiation the vacancy peak vanishes and a peak of interstitial atoms arises. Vacancy concentration can have a maximum close to the dislocation core. Analysis of gas atom mobility at low temperature irradiation indicates a reducing dependence of Xe effective diffusion coefficient on vacancy concentration. The developed physical models enable the proposal of explanations for experimental facts: grain diameter effect on the threshold for the beginning of fuel restructuring and priority formation of large bubbles on dislocation intersections. (author)

  2. Growth and instability of the liquid rim in the crown splash regime

    Agbaglah, G

    2014-01-01

    We study the formation, growth, and disintegration of jets following impact of a drop on a thin film of the same liquid for We < 1000 and Re < 2000 using a combination of numerical simulations and linear stability theory (Agbaglah et al. 2013). Our simulations faithfully capture this phenomena and are in good agreement with experimental profiles obtained from high-speed X-ray imaging.We obtain scaling relations from our simulations and use these as inputs to our stability analysis. The resulting prediction for the most unstable wavelength are in excellent agreement with experimental data. Our calculations show that the dominant destabilizing mechanism is a competition between capillarity and inertia but that deceleration of the rim provides an additional boost to growth. We also predict over the entire parameter range of our study the number and timescale for formation of secondary droplets formed during a splash, based on the assumption that the most unstable mode sets the droplet number.

  3. The insect-trapping rim of Nepenthes pitchers: surface structure and function.

    Bauer, Ulrike; Federle, Walter

    2009-11-01

    Carnivorous pitcher plants of the genus Nepenthes capture prey with a pitfall trap that relies on a micro-structured, slippery surface. The upper pitcher rim (peristome) is fully wettable and causes insects to slip by aquaplaning on a thin water film. The high wettability of the peristome is probably achieved by a combination of hydrophilic surface chemistry, surface roughness and the presence of hygroscopic nectar. Insect foot attachment could be prevented by the delayed drainage of the thin water film between the adhesive pad and the surface. Drainage should be faster for insects with a hairy adhesive system; however, they slip equally on the wet peristome. Therefore the stability of the water film against dewetting appears to be the key factor for aquaplaning. New experimental techniques may help to clarify the detailed function of the pitcher plant peristome and to explore its potential for biomimetic applications. PMID:20009546

  4. Em busca do tradutor: Proust e Mérimée por Mário Quintana.

    Claudia Borges de Faveri

    2005-01-01

    Full Text Available Este artigo pretende estudar as traduções feitas pelo poeta brasileiro Mário Quintana de Carmen, de Prosper Mérimée e de À sombra das raparigas em flor (À l’ombre des jeunes filles en fleur, de Marcel Proust. Com base na análise das etapas do processo tradutório empreendida por Antoine Berman e na abordagem do “tradutor de carne e osso” de Anthony Pym, busca-se a voz tradutor sem acessar os originais, partindo da premissa de que o texto traduzido é capaz de falar por si só. Enfim, tendo em vista a estreita ligação do trabalho de tradução de Quintana com a Editora Globo de Porto Alegre, certo traço da história da tradução no Brasil se fará perceber.

  5. Salicylaldiminato derivatives of cyclotriveratrylene: flexible strategy for new rim-metalated CTV complexes.

    Bohle, D S; Stasko, D J

    2000-12-11

    The amino-derivatized cyclotriveratrylene analogue, triaminotrimethoxytribenzocyclononene [CTV(NH2)3(OMe)3], 1, is readily converted into triply substituted imine compounds [CTV(sal)3(OMe)3], 2, in high yield by treatment of the acid salt of 1 with a variety of substituted salicylaldehydes. Cleavage of the protecting methoxy group generates the tristridentate chelate CTV(sal)3(OH)3, 3, which is readily converted into new rim-metalated species CTV(sal)3(ONiL)3, 4a (a, L = pyrrolidine; b, L = 1-n-butyl-imidazole). Taken together, these results illustrate the remarkable synthetic flexibility that is possible for the CTV-based metal complexes by alteration of the metal, the salicylaldehyde component of the CTV ligand, or the ancillary ligands coordinated to the metal. PMID:11151378

  6. Environmentally assisted cracking of low pressure steam turbine disk-rim material

    Inagaki, H.; Sugita, Y. [Chubu Electric Power Co., Inc., Midoriku, Nagoya (Japan); Kondo, Y.; Bodai, M.; Takel, M. [Mitsubishi Heavy Industries, Ltd., Arai, Takasago (Japan)

    1996-12-31

    At the last stage disk-rim blade attachments of low pressure steam turbines for fossil power units which are subjected to increasing number of start-stop operations, the frequent start-stop operations can be a potential problem in the integrity of the rotor. Environmentally assisted cracking of 3.5 NiCrMoV low alloy steel under cyclic straining was investigated in both the water environment at 60 C in the laboratory and the actual steam environment of a low pressure steam turbine. Effects of strain rate, strain holding time, superposed vibratory stress, impurities and dissolved oxygen in the water environment, on crack initiation life and crack propagation rate were investigated using trapezoidal strain wave form.

  7. Descemet membrane endothelial keratoplasty with a stromal rim in the treatment of posterior polymorphous corneal dystrophy

    Pavel Studeny

    2012-01-01

    Full Text Available A 20-year-old patient, diagnosed with posterior polymorphous corneal dystrophy, developed corneal edema for which he underwent Descemet membrane endothelial keratoplasty with a stromal rim (DMEK-S in the right eye. No intra- or postoperative complications were noted. At the last follow-up 2 years and 9 months after the procedure, the best corrected visual acuity was 1.0 and endothelial cell density declined from 3533 cells/mm 2 to 1012 cells/mm 2 . Despite the endothelial cell loss, DMEK-S appears to be a good alternative to other surgical techniques for the treatment of corneal endotheliopathies, and it may be of benefit to young patients.

  8. The Refined Shock Velocity of the X-Ray Filaments in the RCW 86 Northeast Rim

    Yamaguchi, Hiroya; Katsuda, Satoru; Castro, Daniel; Williams, Brian J.; Lopez, Laura A.; Slane, Patrick O.; Smith, Randall K.; Petre, Robert

    2016-03-01

    A precise measurement of shock velocities is crucial for constraining the mechanism and efficiency of cosmic-ray (CR) acceleration at supernova remnant (SNR) shock fronts. The northeastern rim of the SNR RCW 86 is thought to be a particularly efficient CR acceleration site, owing to the recent result in which an extremely high shock velocity of ˜6000 km s-1 was claimed. Here, we revisit the same SNR rim with the Chandra X-ray Observatory, 11 years after the first observation. This longer baseline than previously available allows us to determine a more accurate proper motion of the nonthermal X-ray filament, revealing a much lower velocity of 3000 ± 340 km s-1 (and even slower at a brighter region). Although the value has dropped to one-half of that from the previous X-ray measurement, it is still higher than the mean velocity of the Hα filaments in this region (˜1200 km s-1). This discrepancy implies that the filaments bright in nonthermal X-rays and Hα emission trace different velocity components, and thus a CR pressure constrained by combining the X-ray kinematics and the Hα spectroscopy can easily be overestimated. We also measure the proper motion of the thermal X-ray filament immediately to the south of the nonthermal one. The inferred velocity (720 ± 360 km s-1) is significantly lower than that of the nonthermal filament, suggesting the presence of denser ambient material, possibly a wall formed by a wind from the progenitor, which has drastically slowed down the shock.

  9. Distal myopathy with rimmed vacuoles: Report on clinical characteristics in 23 cases

    Nalini A

    2010-01-01

    Full Text Available Background: Distal myopathy with rimmed vacuoles (DMRV is an autosomal recessive (AR myopathy characterized clinically by the preferential involvement of the tibialis anterior and has been reported predominantly in the Japanese population. Materials and Methods: A case series of DMRV patients seen over a period of 3 years at a tertiary national referral center for neurological disorders in south India. Results: We describe the clinical characteristics, muscle magnetic resonance imaging (MRI findings and classical histopathological feature in 23 patients. There were 12 men and 11 women. Mean age of onset was 27.04 ± 6.35 years (10-39 years. Onset was in the second or third decade in a majority. Mean age at presentation was 33.95 ± 6.35 years (25-48 years. Mean duration of illness was 6.74 ± 4.8 years (1-18 years. Consanguinity was reported in eight (34.8% patients. The predominant and initial manifestation was bilateral foot drop in all patients. Muscle MRI demonstrated classical involvement of the anterior compartment muscles of the lower legs and the posterior compartment muscles of the thighs and the quadriceps was normal in all. Muscle histopathology showed numerous fibers containing rimmed vacuoles. Necrotic fibers or phagocytosis or regenerating fibers were rarely noted or were absent. Conclusions: DMRV is a rare AR myopathy. The disorder presents as progressive foot drop and hence has many differential diagnoses. It is easily mistaken as neuropathy of hereditary nature and hence it is extremely important to recognize the preferential muscle involvement and characterize the phenotype. This is the first report from India with patients having characteristic phenotype of Nonaka′s/AR hereditary inclusion body myopathy with quadriceps sparing, and all were confirmed by histopathology.

  10. RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays

    Stanislaus, Romesh; Carey, Mark; Deus, Helena F; Coombes, Kevin; Hennessy, Bryan T; Mills, Gordon B; Almeida, Jonas S

    2008-01-01

    Background Reverse Phase Protein Arrays (RPPA) are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technologies, substantial amounts of analytical data are generated. Over 1000 samples may be printed on a single nitrocellulose slide. Up to 100 different proteins may be assessed using immunoperoxidase or immunoflorescence techniques in order to determine relative amounts of protein expression in the samples of interest. Results In this report an RPPA Information Management System (RIMS) is described and made available with open source software. In order to implement the proposed system, we propose a metadata format known as reverse phase protein array markup language (RPPAML). RPPAML would enable researchers to describe, document and disseminate RPPA data. The complexity of the data structure needed to describe the results and the graphic tools necessary to visualize them require a software deployment distributed between a client and a server application. This was achieved without sacrificing interoperability between individual deployments through the use of an open source semantic database, S3DB. This data service backbone is available to multiple client side applications that can also access other server side deployments. The RIMS platform was designed to interoperate with other data analysis and data visualization tools such as Cytoscape. Conclusion The proposed RPPAML data format hopes to standardize RPPA data. Standardization of data would result in diverse client applications being able to operate on the same set of data. Additionally, having data in a standard format would enable data dissemination and data analysis. PMID:19102773

  11. [Microdestruction of the bone].

    Iankovskiĭ, V É

    2014-01-01

    The objective of the present study was the detection of microcracks in the compact bone tissue surrounding the fracture and in deformed bone undergoing subcritical loading. The portions of deformed bone tissue and terminal fragments of broken bones were obtained in the form of blocks longitudinally sawcut from the regions of primary and secondary bone rupture. A total of 300 such blocks were available for the examination. All portions of the deformed bone tissue and terminal fragments of broken bones showed up microcracks commensurate with the bone structures. They were actually hardened traces of deformation that preceded the fracture and reflected the volume of the destroyed bone tissue; moreover, in certain cases they allowed to identify the kind of the object that exerted the external action (either a blow or slow bending). PMID:25269164

  12. Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions

    Balliu, E. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: eballiu@gmail.com; Vilanova, J.C. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: Kvilanova@comg.es; Pelaez, I. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: isapelaezrx@yahoo.es; Puig, J. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: jpuigalcantara@yahoo.es; Remollo, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sremollo@gmail.com; Barcelo, C. [Department of Computer Science and Applied Mathematics, University of Girona (Spain)], E-mail: carles.barcelo@udg.es; Barcelo, J. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: rmgirona@comg.es; Pedraza, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sapedraza@gmail.com

    2009-03-15

    Aim: The aim of this study is to evaluate the value of the apparent diffusion coefficient (ADC) obtained in diffusion-weighted (DW) MR sequences for the differentiation between malignant and benign bone marrow lesions. Method: Forty-five patients with altered signal intensity vertebral bodies on conventional MR sequences were included. The cause of altered signal intensity was benign osteoporotic collapse in 16, acute neoplastic infiltration in 15, and infectious processes in 14; based on plain-film, CT, bone scintigraphy, conventional MR studies, biopsy or follow-up. All patients underwent isotropic DW MR images (multi-shot EPI, b values of 0 and 500 s/mm{sup 2}). Signal intensity at DW MR images was evaluated and ADC values were calculated and compared between malignancy, benign edema and infectious spondylitis. Results: Acute malignant fractures were hyperintense compared to normal vertebral bodies on the diffusion-weighted sequence, except in one patient with sclerotic metastases. Mean ADC value from benign edema (1.9 {+-} 0.39 x 10{sup -3} mm{sup 2}/s) was significantly (p < 0.0001) higher than untreated metastasic lesions (0.9 {+-} 1.3 x 10{sup -3} mm{sup 2}/s). Mean ADC value of infectious spondilytis (0.96 {+-} 0.49 x 10{sup -3} mm{sup 2}/s) was not statistically (p > 0.05) different from untreated metastasic lesions. ADC value was low (0.75 x 10{sup -3} mm{sup 2}/s) in one case of subacute benign fracture. Conclusions: ADC values are a useful complementary tool to characterize bone marrow lesions, in order to distinguish acute benign fractures from malignant or infectious bone lesions. However, ADC values are not valuable in order to differentiate malignancy from infection.

  13. 76 FR 55708 - Servicing Multi-Piece and Single Piece Rim Wheels; Extension of the Office of Management and...

    2011-09-08

    ... Occupational Safety and Health Administration Servicing Multi-Piece and Single Piece Rim Wheels; Extension of... Reduction Act of 1995 (44 U.S.C. 3506 et seq.) and Secretary of Labor's Order No. 4-2010 (75 FR 55355...) Requirements AGENCY: Occupational Safety and Health Administration (OSHA), Labor. ACTION: Request for...

  14. 49 CFR 571.110 - Tire selection and rims and motor home/recreation vehicle trailer load carrying capacity...

    2010-10-01

    ... GAWR of the axle system as specified on the vehicle's certification label required by 49 CFR part 567... certification label specified in 49 CFR part 567. Additionally, each trailer must on its placard contain a cargo... safety standards. (d) A designation that identifies the manufacturer of the rim by name, trademark,...

  15. The Effects of Self-Shadowing by a Puffed up Inner Rim in Scattered Light Images of Protoplanetary Disks

    Dong, Ruobing

    2015-01-01

    We explore whether protoplanetary disks with self-shadowing from puffed up inner rims exhibit observable features in scattered light images. We use both self-consistent hydrostatic equilibrium calculations and parameterized models to produce the vertically puffed up inner rims. We find that, in general, the transition between the shadowed and flared regions occurs in a smooth manner over a broad radius range, and no sudden jump exists at the outer edge of the shadow in either the disk temperature or density structures. As a result, a puffed up rim cannot create sharp ring/arc/spiral-arm-like features in the outer disk as have been detected in recent direct NIR imaging of disks. On the other hand, if the puffed up rim has a sharp edge in the vertical direction, the shadowing effect can produce a distinct 3-stage broken power law in the radial intensity profile of the scattered light, with 2 steep surface brightness radial profiles in the inner and outer disk joined by a shallow transition region around the sha...

  16. Photodissociation of RbI in an Intense Laser Field: Detection of the Product Metal Atom Rb Using RIMS

    HUO Binghai; GAO Jie; CUI Shuanjin; H. H. Telle; Z. T. Salim

    2000-01-01

    It is reported on the recent research using resonant ionization spectroscopy (RIS) and resonant ionization mass spectroscopy (RIMS) to detect the photodissociation product of Rubidium iodide molecules in a molecular beam in an intense laser field. Time of flight mass spectra is recorded. In particular, the appearances of multiphoton ionization are discussed.

  17. Structural uplift and ejecta thickness of lunar mare craters: New insights into the formation of complex crater rims

    Krüger, Tim; Kenkmann, Thomas

    2015-04-01

    Most complex impact craters on solid planetary surfaces throughout the Solar System exhibit elevated crater rims similar to the elevated crater rims of simple craters. In principal the final elevation of the crater rim is due to the deposition of ejecta on the structurally uplifted bedrock of the pre-impact surface. For simple craters the elevated crater rim is due to two well understood factors: (i) Emplacement of the coherent proximal ejecta material at the transient cavity rim (overturned flap) [1]. (ii) Structural uplift of the pre-impact surface in the proximity of the transient cavity [1, 2]. The amount of structural uplift at the rim of simple craters is due to plastic thickening of the target rock, the emplacement of interthrust wedges and/or the injection of dike material in the underlying target [1, 2, 3, 4]. Both factors, (i) and (ii), are believed to equally contribute to the structural uplift of simple craters. Larger craters have complex morphologies and the crater's extent may considerably exceed that of the transient cavity due to gravity-driven adjustment movements. For instance, the Ries crater's final diameter is twice of its transient cavity size. It is expected that both ejecta thickness and structural uplift decrease with increasing distance from the rim of the transient crater. For lunar craters the continuous ejecta extends up to 2 crater radii from the crater center. The ejecta blanket thickness ET at the rim crest of the transient crater (which is inside the final crater) is a function of the distance r from the crater center, with RT as the radius of the transient crater [2, 6, 7] and is expressed by the following function: (1) ET = 0.033 RT (r/RT)^-3.0 for r ≥ RT [5, 6] The structural uplift is largest at the transient cavity rim and gets rapidly smaller with increasing distance to the crater center and disappears after 1.3 - 1.7 crater radii [1]. These circumstances raise the question, how elevated rims of complex craters form? Based

  18. Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis.

    Pathak, Deepika; Bhat, Aadil Hussain; Sapehia, Vandana; Rai, Jagdish; Rao, Alka

    2016-01-01

    Nα-acetylation is a naturally occurring irreversible modification of N-termini of proteins catalyzed by Nα-acetyltransferases (NATs). Although present in all three domains of life, it is little understood in bacteria. The functional grouping of NATs into six types NatA - NatF, in eukaryotes is based on subunit requirements and stringent substrate specificities. Bacterial orthologs are phylogenetically divergent from eukaryotic NATs, and only a couple of them are characterized biochemically. Accordingly, not much is known about their substrate specificities. Rv3420c of Mycobacterium tuberculosis is a NAT ortholog coding for RimI(Mtb). Using in vitro peptide-based enzyme assays and mass-spectrometry methods, we provide evidence that RimI(Mtb) is a protein Nα-acetyltransferase of relaxed substrate specificity mimicking substrate specificities of eukaryotic NatA, NatC and most competently that of NatE. Also, hitherto unknown acetylation of residues namely, Asp, Glu, Tyr and Leu by a bacterial NAT (RimI(Mtb)) is elucidated, in vitro. Based on in vivo acetylation status, in vitro assay results and genetic context, a plausible cellular substrate for RimI(Mtb) is proposed. PMID:27353550

  19. Heterogenous Oxygen Isotopic Composition of a Complex Wark-Lovering Rim and the Margin of a Refractory Inclusion from Leoville

    Simon, J. I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.

    2014-01-01

    Wark-Lovering (WL) rims [1] surrounding many refractory inclusions represent marker events in the early evolution of the Solar System in which many inclusions were exposed to changes in pressure [2], temperature [3], and isotopic reservoirs [4-7]. The effects of these events can be complex, not only producing mineralogical variability of WL rims [2], but also leading to mineralogical [8-10] and isotopic [7, 11, 12] changes within inclusion interiors. Extreme oxygen isotopic heterogeneity measured in CAIs has been explained by mixing between distinct oxygen gas reservoirs in the nebula [13]. Some WL rims contain relatively simple mineral layering and/or are isotopically homogeneous [14, 15]. As part of a larger effort to document and understand the modifications observed in some CAIs, an inclusion (L6) with a complex WL rim from Leoville, a member of the reduced CV3 subgroup was studied. Initial study of the textures and mineral chemistry was presented by [16]. Here we present NanoSIMS oxygen isotopic measurements to complement these petrologic observations.

  20. Spatially Resolved XRF, XRD and Fe-XANES Analysis of Fine-Grained Rims in the Murchison (CM2) Meteorite

    King, A. J.; Schofield, P. F.; Mosselmans, J. F. W.; Russell, S. S.

    2014-09-01

    Fe3+/ΣFe ratios suggest that hydration of fine-grained rims and matrix in the Murchison meteorite occurred in a similar environment. However, local variations in mineralogy and crystal chemistry indicate that the alteration varied at the μm-scale.

  1. Influence of task complexity on mechanical efficiency and propulsion technique during learning of hand rim wheelchair propulsion

    de Groot, S; Veeger, H E J; Hollander, A P; van der Woude, L H V

    2005-01-01

    OBJECTIVE: To investigate the consequence of task complexity on gross mechanical efficiency and propulsion technique during the learning process of hand rim wheelchair propulsion. METHODS: Three groups of unimpaired subjects (N=10 each) received a 3-week wheelchair practice period (3 week(-1), nine

  2. Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis

    Pathak, Deepika; Bhat, Aadil Hussain; Sapehia, Vandana; Rai, Jagdish; Rao, Alka

    2016-01-01

    Nα-acetylation is a naturally occurring irreversible modification of N-termini of proteins catalyzed by Nα-acetyltransferases (NATs). Although present in all three domains of life, it is little understood in bacteria. The functional grouping of NATs into six types NatA - NatF, in eukaryotes is based on subunit requirements and stringent substrate specificities. Bacterial orthologs are phylogenetically divergent from eukaryotic NATs, and only a couple of them are characterized biochemically. Accordingly, not much is known about their substrate specificities. Rv3420c of Mycobacterium tuberculosis is a NAT ortholog coding for RimIMtb. Using in vitro peptide-based enzyme assays and mass-spectrometry methods, we provide evidence that RimIMtb is a protein Nα-acetyltransferase of relaxed substrate specificity mimicking substrate specificities of eukaryotic NatA, NatC and most competently that of NatE. Also, hitherto unknown acetylation of residues namely, Asp, Glu, Tyr and Leu by a bacterial NAT (RimIMtb) is elucidated, in vitro. Based on in vivo acetylation status, in vitro assay results and genetic context, a plausible cellular substrate for RimIMtb is proposed. PMID:27353550

  3. 16 CFR Table 3 to Part 1512 - Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test...

    2010-01-01

    ... Defined in the Retroreflective Tire and Rim Test Procedure 3 Table 3 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR BICYCLES... Retroreflective Tire and Rim Test Procedure Observation angle (degrees) Entrance angle (degrees)...

  4. Experimental study on the rim-enhancing lesion of rabbit brain abscess : MR imaging and histopathologic correlation

    Lee, Hee Jung; Suh, Soo Jhi; Kim, Sang Pyo; Joo, Yang Goo; Zeon, Seok Kil; Woo, Seong Ku [Keimyung Univ. School of Medicine, Taegu (Korea, Republic of)

    1996-11-01

    To evaluate on the basis of histopathologic carrelation the MR findings of mature brain abscess in the rabbit, with particular attention to rim-enhancing lesions. The evolution of abscess formation was obtained by the direct inoculation of Staphylococcus aureus into the gray-white matter junctions of the brains of 16 rabbits. The stages of brain abscesses were divided into four : early cerebritis (days 1 to 5 after inoculation of the organism);late cerebritis (days 6 to 14);early capsular (days 16 to 21);and late capsular (days 22 to 28). The available MR images showed 14 cases at the stage of early cerebritis, seven at the late cerebritis stage, three at the early capsular, and one at the late capsular stage. According to the known pathology of brain abscesses and on the basis of both MR imaging and histopathologic findings, the lesions were grouped according to whether they were found in the central necrotic, border, or peripheral zone. We analyzed the patterns of rim-enhancement (completeness of the rim, thickness, and margin) and the signal intensities of the abscess walls on MR images at each stage. Histopathologic correlation was performed in one case of each stage. We evaluated the presence or absence and degree of infiltration by inflammatory granulation tissue, microhemorrhage, reticulin, collagen, and hemosiderin of the abscess walls. Rim-enhancing lesions were present in three of 14 cases at the late cerebritis stage, in all three cases at the early capsular, in one at the late capsular, but in none at the early cerebritis stage. The enhancing pattern of the late cerebritis stage was irregular-margined incomplete rim-enhancement, with irregular thickness of the abscess walls (3/3). The enhancing pattern of the capsular stages was well-defined, complete rim-enhancement with uniform thickness of the abscess walls (3/4). The signal intensities of the abscess walls at the late cerebritis and early capsular stages were variable. The late capsular stage ws

  5. Experimental study on the rim-enhancing lesion of rabbit brain abscess : MR imaging and histopathologic correlation

    To evaluate on the basis of histopathologic carrelation the MR findings of mature brain abscess in the rabbit, with particular attention to rim-enhancing lesions. The evolution of abscess formation was obtained by the direct inoculation of Staphylococcus aureus into the gray-white matter junctions of the brains of 16 rabbits. The stages of brain abscesses were divided into four : early cerebritis (days 1 to 5 after inoculation of the organism);late cerebritis (days 6 to 14);early capsular (days 16 to 21);and late capsular (days 22 to 28). The available MR images showed 14 cases at the stage of early cerebritis, seven at the late cerebritis stage, three at the early capsular, and one at the late capsular stage. According to the known pathology of brain abscesses and on the basis of both MR imaging and histopathologic findings, the lesions were grouped according to whether they were found in the central necrotic, border, or peripheral zone. We analyzed the patterns of rim-enhancement (completeness of the rim, thickness, and margin) and the signal intensities of the abscess walls on MR images at each stage. Histopathologic correlation was performed in one case of each stage. We evaluated the presence or absence and degree of infiltration by inflammatory granulation tissue, microhemorrhage, reticulin, collagen, and hemosiderin of the abscess walls. Rim-enhancing lesions were present in three of 14 cases at the late cerebritis stage, in all three cases at the early capsular, in one at the late capsular, but in none at the early cerebritis stage. The enhancing pattern of the late cerebritis stage was irregular-margined incomplete rim-enhancement, with irregular thickness of the abscess walls (3/3). The enhancing pattern of the capsular stages was well-defined, complete rim-enhancement with uniform thickness of the abscess walls (3/4). The signal intensities of the abscess walls at the late cerebritis and early capsular stages were variable. The late capsular stage ws

  6. How Is Bone Cancer Diagnosed?

    ... with bone cancer. Accurate diagnosis of a bone tumor often depends on combining information about its location (what bone is affected and even which part of the bone is involved), appearance on x-rays, and appearance under a microscope. ...

  7. Bone marrow (stem cell) donation

    ... lymphoma , and myeloma can be treated with a bone marrow transplant . This is now often called a stem cell ... are two types of bone marrow donation: Autologous bone marrow transplant is when people donate their own bone marrow. " ...

  8. Bone Graft Alternatives

    ... cadavers. The types of allograft bone used for spine surgery include fresh frozen and lyophilized (freeze dried). The ... the most common uses of bone grafts in spine surgery is during spinal fusion. The use of autogenous ...

  9. Bone Loss in IBD

    ... DENSITY? Although bone seems as hard as a rock, it’s actually living tissue. Throughout your life, old ... available Bone Loss (.pdf) File: 290 KB 733 Third Avenue, Suite 510, New York, NY 10017 | 800- ...

  10. Bone mineral density test

    ... Paula FJA, Black DM, Rosen CJ. Osteoporosis and bone biology.In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology . 13th ed. Philadelphia, ... Bone-density testing interval and transition to osteoporosis in ...

  11. Bone mineral density test

    BMD test; Bone density test; Bone densitometry; DEXA scan; DXA; Dual-energy x-ray absorptiometry; p-DEXA; Osteoporosis-BMD ... need to undress. This scan is the best test to predict your risk of fractures. Peripheral DEXA ( ...

  12. Smoking and Bone Health

    ... It has been called a childhood disease with old age consequences because building healthy bones in youth helps ... stronger. Weight-bearing exercise that forces you to work against gravity is the best exercise for bone. ...

  13. RIM-DB: a taxonomic framework for community structure analysis of methanogenic archaea from the rumen and other intestinal environments

    Henning Seedorf

    2014-08-01

    Full Text Available Methane is formed by methanogenic archaea in the rumen as one of the end products of feed fermentation in the ruminant digestive tract. To develop strategies to mitigate anthropogenic methane emissions due to ruminant farming, and to understand rumen microbial differences in animal feed conversion efficiency, it is essential that methanogens can be identified and taxonomically classified with high accuracy. Currently available taxonomic frameworks offer only limited resolution beyond the genus level for taxonomic assignments of sequence data stemming from high throughput sequencing technologies. Therefore, we have developed a QIIME-compatible database (DB designed for species-level taxonomic assignment of 16S rRNA gene amplicon data targeting methanogenic archaea from the rumen, and from animal and human intestinal tracts. Called RIM-DB (Rumen and Intestinal Methanogen-DB, it contains a set of 2,379 almost full-length chimera-checked 16S rRNA gene sequences, including 20 previously unpublished sequences from isolates from three different orders. The taxonomy encompasses the recently-proposed seventh order of methanogens, the Methanomassiliicoccales, and allows differentiation between defined groups within this order. Sequence reads from rumen contents from a range of ruminant-diet combinations were taxonomically assigned using RIM-DB, Greengenes and SILVA. This comparison clearly showed that taxonomic assignments with RIM-DB resulted in the most detailed assignment, and only RIM-DB taxonomic assignments allowed methanogens to be distinguished taxonomically at the species level. RIM-DB complements the use of comprehensive databases such as Greengenes and SILVA for community structure analysis of methanogens from the rumen and other intestinal environments, and allows identification of target species for methane mitigation strategies.

  14. A Chandra Observation of the Luminous Northeastern Rim of the Galactic Supernova Remnant W28 (G6.4-0.1)

    Pannuti, Thomas

    2016-06-01

    We present an analysis of a pointed observation made of the luminous northeastern rim of the Galactic supernova remnant (SNR) W28 (G6.4-0.1) with the Chandra X-ray Observatory. W28 is the archetype for the class of SNRs known as the mixed-morphology SNRs: sources in this class of objects feature a shell-like morphology with a contrasting center-filled X-ray morphology. Almost unique amongst mixed-morphology SNRs, W28 exhibits a luminous northeastern rim which is detected in the X-ray, optical and radio: this rim is also the site of a vigorous interaction between W28 and adjacent molecular clouds, as evidenced by the high concentration of hydroxyl (OH) masers seen at this rim. Our pointed Chandra observation of this rim is the highest angular X-ray observation made of this feature: initial analysis and results will be presented and discussed.

  15. Bone regeneration in dentistry

    Tonelli, Paolo; Duvina, Marco; Barbato, Luigi; Biondi, Eleonora; Nuti, Niccolò; Brancato, Leila; Rose, Giovanna Delle

    2011-01-01

    The edentulism of the jaws and the periodontal disease represent conditions that frequently leads to disruption of the alveolar bone. The loss of the tooth and of its bone of support lead to the creation of crestal defects or situation of maxillary atrophy. The restoration of a functional condition involves the use of endosseous implants who require adequate bone volume, to deal with the masticatory load. In such situations the bone need to be regenerated, taking advantage of the biological p...

  16. Eating disorders and bone.

    Tomlinson, Dale; Morgan, Sarah L

    2013-01-01

    Low bone mineral density (BMD) is a frequent and often-overlooked consequence of eating disorders, in particular anorexia nervosa and eating disorders associated with the female athlete triad. The causes of low BMD are multifactorial and include low peak bone mass accrual, accelerated bone resorption, and changes in bone microarchitecture. Early diagnosis and interventions focused on nutritional rehabilitation and weight gain reduce the risk of further BMD deficits and fractures. PMID:24094471

  17. Bone densitometry and osteoporosis

    The purpose of this book is to provide a perspective on the current status of bone densitometry and its relevance to osteoporosis diagnosis and management. Therefore, this book will give the reader an introduction to the nature of osteoporosis, its pathophysiology and epidemiology, and the clinical consequences of performing bone densitometry. Aside from standard bone densitometry, newer technologies such as quantitative ultrasound techniques, magnetic resonance imaging and bone structure analysis are discussed in the context of diagnosing osteoporosis. (orig.)

  18. BONE MECHANOTRANSDUCTION: A REVIEW

    Reis, Joana; Capela e Silva, Fernando; Queiroga, Cristina; Lucena, Sónia; Potes, José

    2011-01-01

    This review focus on the bone physiology and mechanotransduction elements and mechanisms. Bone biology and architecture is deeply related to the mechanical environment. Orthopaedic implants cause profound changes in the biomechanics and electrophysiology of the skeleton. In the context of biomedical engineering, a deep reflexion on bone physiology and electromechanics is needed. Strategic development of new biomaterials and devices that respect and promote continuity with bone str...

  19. Magnetic resonance imaging of bone marrow changes in Gaucher disease during enzyme replacement therapy: first German long-term results

    Poll, L.W.; Koch, J.A.; Scherer, A.; Boerner, D.; Moedder, U. [Duesseldorf Univ. (Germany). Inst. fuer Diagnostische Radiologie; Dahl, S. vom; Niederau, C.; Haeussinger, D. [Duesseldorf Univ. (Germany). Medizinische Fakultaet; Willers, R. [Duesseldorf Univ. (Germany). Rechenzentrum

    2001-09-01

    Objective:. Since 1991, enzyme replacement therapy (ERT) has been available for patients with Gaucher disease in Germany. The aim of this study was to analyse the MR pattern of bone marrow involvement and response to ERT in Gaucher disease type I. Patients and design:. Thirty patients with Gaucher disease type I had MRI examinations prior to initiation of ERT with alglucerase/imiglucerase and during follow-up. Median MR follow-up and duration of ERT were 36 months. Coronal T1- and T2-weighted spin-echo images of the lower extremities were obtained to evaluate changes in the appearance of yellow marrow. MR images were categorized as having either a homogeneous (type A) or non-homogeneous patchy (type B) appearance of bone involvement and response to ERT was assessed by two radiologists. Results:. Overall, 19 of 30 patients (63%) showed an increased signal intensity on T1- and T2-weighted images after 36 months of ERT, consistent with partial reconversion of fatty marrow during treatment. Focal bone lesions surrounded by a low signal intensity (SI) rim did not respond to ERT, suggesting bone infarcts. Of the 11 patients with bone infarcts (low SI rim lesion), 82% had the non-homogeneous type B pattern (P=0.0021). In 86% of patients with splenectomy, bone infarcts were seen (P<0.05). Conclusions:. MRI using T1- and T2-weighted spin-echo sequences is a valuable, non-invasive method for monitoring bone marrow response in patients receiving ERT. A non- homogeneous patchy signal intensity of bone marrow involvement correlates with the presence of bone infarcts (P=0.0021). (orig.)

  20. Comparative imaging study for soft tissue changes in osteomyelitis and malignant bone tumor

    Objective: To investigate the value of the imaging findings of soft tissue abnormality in the differential diagnosis between osteomyelitis and malignant bone tumor. Methods: The CT and MRI findings of soft tissue changes in 57 cases of osteomyelitis and 70 cases of malignant bone tumor were retrospectively defined,observed, recorded and statistically analyzed. Results: In 57 cases of osteomyelitis, 54 cases were examined with CT, and soft tissue swelling was presented in 52 cases (degree I in 19 cases, degree II in 16 cases, degree III in 17 cases). Abscess-like cysts in soft tissue occurred in 6 cases, masses in 5, air in 1, fat-fluid level in 1 and sinus tract in 1. Among 14 cases examined with MR imaging, soft tissue swelling was presented in all cases (degree I in 2 cases, degree II in 6 cases and degree III in 6 cases). Abscess-like cysts appeared in 3 cases and showed high signal in diffusion weighted imaging, mass in 1 and fat-fluid level in 1. Among 54 cases examined with CT in 70 cases of malignant bone tumor, soft tissue swelling was presented in 44 cases (degree I in 29 cases, degree II in 12 cases, degree III in 3 cases). Soft tissue masses appeared in 49 cases, bone shell and shell-like calcification in 16 cases, and neoplastic bone and neoplastic calcified cartilage within soft tissue mass in 25 cases. Among 49 cases examined with MR imaging, soft tissue swelling was presented in 46 cases (degree I in 21 cases, degree II in 17 cases and degree III in 8 cases), and soft tissue masses appeared in 43 cases. The degree of soft tissue swelling and the occurrence of abscess-like cyst, mass, bone shell or shell-liked calcification in the rim of mass, neoplastic bone or neoplastic calcified cartilage in masses showed significant difference (P<0.05) between osteomyelitis group and malignant bone tumor group on CT examination. The degree of Soft tissue swelling and the occurrence frequency of abscess-like cysts and mass were significantly different (P<0

  1. Bone cysts: unicameral and aneurysmal bone cyst.

    Mascard, E; Gomez-Brouchet, A; Lambot, K

    2015-02-01

    Simple and aneurysmal bone cysts are benign lytic bone lesions, usually encountered in children and adolescents. Simple bone cyst is a cystic, fluid-filled lesion, which may be unicameral (UBC) or partially separated. UBC can involve all bones, but usually the long bone metaphysis and otherwise primarily the proximal humerus and proximal femur. The classic aneurysmal bone cyst (ABC) is an expansive and hemorrhagic tumor, usually showing characteristic translocation. About 30% of ABCs are secondary, without translocation; they occur in reaction to another, usually benign, bone lesion. ABCs are metaphyseal, excentric, bulging, fluid-filled and multicameral, and may develop in all bones of the skeleton. On MRI, the fluid level is evocative. It is mandatory to distinguish ABC from UBC, as prognosis and treatment are different. UBCs resolve spontaneously between adolescence and adulthood; the main concern is the risk of pathologic fracture. Treatment in non-threatening forms consists in intracystic injection of methylprednisolone. When there is a risk of fracture, especially of the femoral neck, surgery with curettage, filling with bone substitute or graft and osteosynthesis may be required. ABCs are potentially more aggressive, with a risk of bone destruction. Diagnosis must systematically be confirmed by biopsy, identifying soft-tissue parts, as telangiectatic sarcoma can mimic ABC. Intra-lesional sclerotherapy with alcohol is an effective treatment. In spinal ABC and in aggressive lesions with a risk of fracture, surgical treatment should be preferred, possibly after preoperative embolization. The risk of malignant transformation is very low, except in case of radiation therapy. PMID:25579825

  2. Menopause and Bone Loss

    Fact Sheet & Menopause Bone Loss How are bone loss and menopause related? Throughout life your body keeps a balance between the loss ... The sooner you take steps to prevent bone loss, the lower your risk of osteoporosis later in life. If you are skipping menstrual periods, have had ...

  3. What's a Funny Bone?

    ... Help White House Lunch Recipes What's a Funny Bone? KidsHealth > For Kids > What's a Funny Bone? Print A A A Text Size Have you ... prickly kind of dull pain? That's your funny bone! It doesn't really hurt as much as ...

  4. The rim zone of cement based materials - barrier or fast lane for chemical degradation?

    This contribution focuses exemplarily on the chemical and mineralogical changes in the rim zone of cement paste samples exposed to different chloride solutions (NaCl, KCl, MgCl2 and CaCl2), to hard tap water and to demineralized water. The determination of the Ca(OH)2 and Mg(OH)2 content of the solid phases was performed by means of thermogravimetry with pulverized samples (TGA/SDTA 851, Mettler-Toledo). A potential relation between temperature and the time dependant development of the material due to reactive transport processes will also be addressed. The experiments with tap water showed that the contact between the cement paste samples and hard tap water did not lead to significant changes in the composition of the solid samples or of the reaction solution. This can be attributed to a rapid formation of a protective calcium carbonate layer on the surface of the cement paste. The slight decrease of the Ca2+ content in the solution indicates that the growth of this layer occurs within the first few hours. In contrast to the tap water exposure, the results of the experiments with the MgCl2 solutions show features of an intense attack despite the presence of crystalline covering layers. The quick formation of a thick and dense Mg(OH)2 layer does not provide any protection against reactive transport processes. In this experiment, the degradation rate of Ca(OH)2 as well as the Ca2+ release was higher than in all other experiments. In addition the rapid formation of a Mg(OH)2 layer starting already during the first hour of the experiment did not prevent the chloride ingress compared to the other experiments with chloride solutions. The pH value of the reaction solution remains stable and relatively low which indicates a crystallisation process. In the other experiments, performed with demineralized water, alkali chloride solutions, and the CaCl2 solution, no significant formation of potentially protective covering layers and no development of transport inhibiting

  5. Petrographic and SIMS pyrite sulfur isotope analyses of Ediacaran chert nodules: Implications for microbial processes in pyrite rim formation, silicification, and exceptional fossil preservation

    Xiao, Shuhai; Schiffbauer, James D.; McFadden, Kathleen A.; Hunter, Jerry

    2010-09-01

    The lower Ediacaran Doushantuo Formation in the Yangtze Gorges area contains exceptionally preserved microfossils, including the earliest known animal resting eggs and embryos. These fossils are preserved in cm-sized chert nodules, which typically have a microbial mat fragment in the center, a silica cortex, a pyrite rim, and an outer rim of blocky calcite. Petrographic analysis indicates that the formation of the blocky calcite rim postdates that of the pyrite rim and silica cortex. The pyrite rim grew centripetally during early diagenesis, representing a reaction front that was determined by the dynamics between ambient Fe 2+ and H 2S, the latter of which was derived from bacterial sulfate reduction (BSR) of mat fragment in nodule center. The silica cortex was formed pervasively through replacement of carbonate sediments prior to compaction. Secondary ion mass spectroscopy (SIMS) sulfur isotopes of individual pyrite crystals (δ 34S py - SIMS) in pyrite rims and matrices show highly positive values (15.2-39.8‰). The pyrite rims do not show an isotopic gradient between small crystals formed in outer rim during early diagenesis and large crystals formed in inner rim during subsequent overgrowth. Although rim pyrite in the same chert nodule has consistent δ 34S py - SIMS values, there are significant spatial and stratigraphic variations in δ 34S py - SIMS values of both matrix and rim pyrite. Overall, isotopic fractionation between pyrite and carbonate associated sulfate (CAS) is small (< 22‰). The isotopic and petrographic data can be interpreted as evidence for rapid BSR of highly metabolizable organic matter in a diagenetic environment with limited sulfate availability, local anoxia, high Fe 2+ concentration, and low sedimentation rate. The embryonic nodules nucleated on microbial mat fragments and stayed in the BSR zone during early diagenesis, when rapid BSR in the nodule center generated outward-diffusing H 2S that was confined by readily available Fe 2

  6. Enzymatic maceration of bone

    Uhre, Marie-Louise; Eriksen, Anne Marie; Simonsen, Kim Pilkjær;

    2015-01-01

    afterwards macerated by one of the two methods. DNA extraction was performed to see the effect of the macerations on DNA preservation. Furthermore, the bone pieces were examined in a stereomicroscope to assess for any bone damage. The results demonstrated that both methods removed all flesh/soft tissue from...... the bones. The DNA analysis showed that DNA was preserved on all the pieces of bones which were examined. Finally, the investigation suggests that enzyme maceration could be gentler on the bones, as the edges appeared less frayed. The enzyme maceration was also a quicker method; it took three hours...

  7. Tin in Human Bones

    Jambor, Jaroslav; Smreka, Vâclav

    1993-01-01

    TIN IN HUMAN BONES. The tin content in the bones of 149 skeletons from the 1st - 5th centuries A.D., and of 11 individuals of the recent population was determined. The bone samples were carbonized and analyzed through emission spectroscopy with a.c. excitation. The tin content in bones of recent populations not exposed to extra tin supply is about one order of magnitude higher than is the case with the bones od some populations that lived at the beginning of our era. The distribut...

  8. Impact of ionic liquids on europium and americium extraction by an upper rim phosphorylated calixarene

    The solvent extraction of europium and americium using the calixarene 5,11,17,23-tetrakis[dipropylphosphinylmethyl] 25,26,27,28-tetrapropoxycalix[4]arene (conical conformation) in the presence of ionic liquids with different natures was studied. It was shown that upper rim phosphorylated calixarene is able to extract europium and americium from nitric acid to dichloroethane by forming a 1:1 complex without the addition of ionic liquids. The distribution coefficients of americium are higher than those of europium in this case, but the isolation degrees of both elements are insufficient for this system to be useful in extraction technologies. The addition of the ionic liquid trihexyl(tetradecyl)phosphonium hexafluorophosphate increases the europium distribution coefficient by values ranging from twofold to more than two orders of magnitude at ionic liquid concentrations of 1 and 50 %, respectively. The values of the distribution coefficients for americium are increased by approximately 25-fold after a 50 % addition of the ionic liquid. (author)

  9. Resonance Ionization Mass Spectrometry (RIMS) with Pulsed and CW-Lasers on Plutonium

    Kunz, P.; Huber, G.; Passler, G.; Trautmann, N.; Wendt, K.

    2005-04-01

    The detection of long-lived plutonium isotopes in ultra-trace amounts by resonance ionization mass spectrometry (RIMS) is a well-established routine method. Detection limits of 106 to 107 atoms and precise measurements of the isotopic composition have been achieved. In this work multi-step resonance ionization of plutonium atoms has been performed with tunable lasers having very different output intensities and spectral properties. In order to compare different ways for the resonance ionization of plutonium broadband pulsed dye and titanium:sapphire lasers as well as narrow-band cw-diode and titanium:sapphire lasers have been applied for a number of efficient excitation schemes. It has been shown, that for identical excitation schemes the optical isotope selectivity can be improved by using cw-lasers (bandwidths lasers (bandwidths > 2 GHz). Pulsed and cw-laser systems have been used simultaneously for resonance ionization enabling direct comparisons of pulsed and continuous ionization processes. So far, a three-step, three-color laser excitation scheme has been proven to be most practical in terms of efficiency, selectivity and laser wavelengths. Alternatively a newly discovered three-step, two-color excitation scheme which includes a strong two-photon transition from an excited state into a high-lying autoionizing state yields similar ionization efficiencies. This two-photon transition was characterized with respect to saturation behavior and line width.

  10. Resonance Ionization Mass Spectrometry (RIMS) with Pulsed and CW-Lasers on Plutonium

    The detection of long-lived plutonium isotopes in ultra-trace amounts by resonance ionization mass spectrometry (RIMS) is a well-established routine method. Detection limits of 106 to 107 atoms and precise measurements of the isotopic composition have been achieved. In this work multi-step resonance ionization of plutonium atoms has been performed with tunable lasers having very different output intensities and spectral properties. In order to compare different ways for the resonance ionization of plutonium broadband pulsed dye and titanium:sapphire lasers as well as narrow-band cw-diode and titanium:sapphire lasers have been applied for a number of efficient excitation schemes. It has been shown, that for identical excitation schemes the optical isotope selectivity can be improved by using cw-lasers (bandwidths 2 GHz). Pulsed and cw-laser systems have been used simultaneously for resonance ionization enabling direct comparisons of pulsed and continuous ionization processes. So far, a three-step, three-color laser excitation scheme has been proven to be most practical in terms of efficiency, selectivity and laser wavelengths. Alternatively a newly discovered three-step, two-color excitation scheme which includes a strong two-photon transition from an excited state into a high-lying autoionizing state yields similar ionization efficiencies. This two-photon transition was characterized with respect to saturation behavior and line width.

  11. Radiation thermo-chemical models of protoplanetary disks I. Hydrostatic disk structure and inner rim

    Woitke, Peter; Thi, Wing-Fai

    2009-01-01

    This paper introduces a new disk code, called ProDiMo, to calculate the thermo-chemical structure of protoplanetary disks and to interpret gas emission lines from UV to sub-mm. We combine frequency-dependent 2D dust continuum radiative transfer, kinetic gas-phase and UV photo-chemistry, ice formation, and detailed non-LTE heating & cooling balance with the consistent calculation of the hydrostatic disk structure. We include FeII and CO ro-vibrational line heating/cooling relevant for the high-density gas close to the star, and apply a modified escape probability treatment. The models are characterized by a high degree of consistency between the various physical, chemical and radiative processes, where the mutual feedbacks are solved iteratively. In application to a T Tauri disk extending from 0.5AU to 500AU, the models are featured by a puffed-up inner rim and show that the dense, shielded and cold midplane (z/r<0.1, Tg~Td) is surrounded by a layer of hot (5000K) and thin (10^7 to 10^8 cm^-3) atomic ga...

  12. Collapse and expansion in the bright-rimmed cloud SFO 11NE

    White, M A T G J

    2004-01-01

    We report the results of a search for the double-peaked blue-skewed infall signature in the bright-rimmed cloud core SFO 11NE SMM1. Observations of the optically thick HCO$^{+}$ and optically thin H$^{13}$CO$^{+}$ J=3--2 lines reveal that there is indeed a characteristic double-peaked line profile, but skewed to the red rather than the blue. Modelling of the dust continuum emission and line profiles show that the motions within SFO 11NE SMM1 are consistent with a collapsing central core surrounded by an expanding outer envelope. We show that the collapse is occurring at a similar rate to that expected onto a single solar-mass protostar and is unlikely to represent the large-scale collapse of gas onto the infrared cluster seen at the heart of SFO 11NE SMM1. The outer envelope is expanding at a much greater rate than that expected for a photoevaporated flow from the cloud surface. The modelled expansion is consistent with the bulk cloud re-expansion phase predicted by radiative-driven implosion models of cometa...

  13. Model for evolution of grain size in the rim region of high burnup UO2 fuel

    Xiao, Hongxing; Long, Chongsheng; Chen, Hongsheng

    2016-04-01

    The restructuring process of the high burnup structure (HBS) formation in UO2 fuel results in sub-micron size grains that accelerate the fission gas swelling, which will raise some concern over the safety of extended the nuclear fuel operation life in the reactor. A mechanistic and engineering model for evolution of grain size in the rim region of high burnup UO2 fuel based on the experimental observations of the HBS in the literature is presented. The model takes into account dislocations evolution under irradiation and the grain subdivision occur successively at increasing local burnup. It is assumed that the original driving force for subdivision of grain in the HBS of UO2 fuel is the production and accumulation of dislocation loops during irradiation. The dislocation loops can also be annealed through thermal diffusion when the temperature is high enough. The capability of this model is validated by the comparison with the experimental data of temperature threshold of subdivision, dislocation density and sub-grain size as a function of local burnup. It is shown that the calculated results of the dislocation density and subdivided grain size as a function of local burnup are in good agreement with the experimental results.

  14. Mixed multiplicities for arbitrary ideals and generalized Buchsbaum-Rim multiplicities

    We introduce first the notion of mixed multiplicities for arbitrary ideals in a local d-dimensional noetherian ring (A, m) which, in some sense, generalizes the concept of mixed multiplicities for m-primary ideals. We also generalize Teissier's Product Formula for a set of arbitrary ideals. We also extend the notion of the Buchsbaum-Rim multiplicity (in short, we write BR-multiplicity) of a submodule of a free module to the case where the submodule no longer has finite colength. For a submodule M of Ap we introduce a sequence eBRk(M), k = 0,...,d + p - 1 which in the ideal case coincides with the multiplicity sequence c0(I, A),...,cd(I, A) defined for an arbitrary ideal I of A by Achilles and Manaresi in [AM]. In case that M has finite colength in Ap and it is totally decomposable we prove that our BR-multiplicity sequence essentially falls into the standard BR-multiplicity of M. (author)

  15. Building for the Pacific Rim Countries. Energy-efficient building strategies for hot, humid climates

    Sheinkopf, K. [ed.

    1991-09-01

    This book has been published by the Solar Energy Industries Association (SEIA), the US trade association of the solar thermal, photovoltaic, and passive solar manufacturers, distributors, and component suppliers. Its purpose is to help architects, builders, and developers construct energy-efficient homes in hot humid climates like the Pacific Rim Countries, and to allow occupants of these homes to enjoy enhanced comfort without reliance on mechanical air-conditioning systems. Two important factors are addressed in this book. First, the past few years have seen a tremendous increase in practical applications of new research. The current popularity of ceiling paddle fans, attic radiant barriers and natural daylighting attest to the importance of keeping up with the latest concepts in energy-reduction and comfort-awareness. Professionals who have been in the field for the past few years may be unaware of the latest research findings--some of which dramatically alter prior thinking on such subjects as natural ventilation or mechanical air conditioning. The second factor is the importance of site-specific characteristics, which greatly affect building strategies and designs. A thorough understanding of the climate is a prerequisite to good building design. Such factors as temperature, humidity, wind speed and direction, and solar radiation must be understood and properly integrated into the design for the home to be truly energy-efficient.

  16. The Difference in Translaminar Pressure Gradient and Neuroretinal Rim Area in Glaucoma and Healthy Subjects

    Lina Siaudvytyte

    2014-01-01

    Full Text Available Purpose. To assess differences in translaminar pressure gradient (TPG and neuroretinal rim area (NRA in patients with normal tension glaucoma (NTG, high tension glaucoma (HTG, and healthy controls. Methods. 27 patients with NTG, HTG, and healthy controls were included in the prospective pilot study (each group consisted of 9 patients. Intraocular pressure (IOP, intracranial pressure (ICP, and confocal laser scanning tomography were assessed. TPG was calculated as the difference of IOP minus ICP. ICP was measured using noninvasive two-depth transcranial Doppler device. The level of significance P 0.05. The difference between TPG for healthy (5.4(7.7 mmHg and glaucomatous eyes (NTG 6.3(3.1 mmHg, HTG 15.7(7.7 mmHg was statistically significant (P < 0.001. Higher TPG was correlated with decreased NRA (r = −0.83; P = 0.01 in the NTG group. Conclusion. Translaminar pressure gradient was higher in glaucoma patients. Reduction of NRA was related to higher TPG in NTG patients. Further prospective studies are warranted to investigate the involvement of TPG in glaucoma management.

  17. H$_2$O maser emission from bright rimmed clouds in the northern hemisphere

    Valdettaro, R; Brand, J; Cesaroni, R

    2005-01-01

    We report the results of a multi-epoch survey of water maser observations at 22.2 GHz with the Medicina radiotelescope from 44 bright rimmed clouds (BRCs) of the northern hemisphere identified by Sugitani et al. (1989) as potential sites of star formation. The data span 16 years of observations and allow to draw conclusions about the maser detection rate in this class of objects. In spite of the relatively high far-infrared luminosities of the embedded sources ($L_{\\rm FIR}\\ga 10^2$ L$_\\odot$), H$_2$O maser emission was detected towards three globules only. Since the occurrence of water masers is higher towards bright IRAS sources, the lack of frequent H$_2$O maser emission is somewhat surprising if the suggestion of induced intermediate- and high-mass star formation within these globules is correct. The maser properties of two BRCs are characteristic of exciting sources of low-mass, while the last one (BRC~38) is consistent with an intermediate-mass object. We argue that most BRCs host young stellar objects ...

  18. Structural studies of eight bright rimmed clouds in the southern hemisphere

    Sharma, Saurabh; Borissova, J; Ojha, D K; Ivanov, V D; Ogura, K; Kobayashi, N; Kurtev, R; Gopinathan, M; Yadav, Ram Kesh

    2016-01-01

    We carried out deep and wide-field near- and mid-infrared observations for a sample of 8 bright-rimmed clouds (BRCs). Supplemented with the $Spitzer$ archival data, we have identified and classified 44 to 433 young stellar objects (YSOs) associated with these BRCs. The Class I sources are generally located towards the places with higher extinction and are relatively closer to each other than the Class II sources, confirming that the young protostars are usually found in regions having denser molecular material. On the other hand the comparatively older population, Class II objects, are more randomly found throughout the regions, which can be due to their dynamical evolution. Using the minimal sampling tree analyses, we have extracted 13 stellar cores of 8 or more members, which contains 60\\% of the total YSOs. The typical core is $\\sim$0.6 pc in radii and somewhat elongated (aspect ratio of 1.45), of relatively low stellar density (surface density 60 pc$^{-2}$), consisting of a small (35) number of YSOs of re...

  19. Bone stress injuries

    Bone stress injuries are due to cyclical overuse of the bone. They are relatively common in athletes and military recruits but also among otherwise healthy people who have recently started new or intensive physical activity. Diagnosis of bone stress injuries is based on the patient's history of increased physical activity and on imaging findings. The general symptom of a bone stress injury is stress-related pain. Bone stress injuries are difficult to diagnose based only on a clinical examination because the clinical symptoms may vary depending on the phase of the pathophysiological spectrum in the bone stress injury. Imaging studies are needed to ensure an early and exact diagnosis, because if the diagnosis is not delayed most bone stress injuries heal well without complications

  20. CHRONIC OTITIS MEDIA: HIGH RESOLUTION COMPUTED TOMOGRAPHIC EVALUATION OF THE TEMPORAL BONE WITH SURGICAL CORRELATION

    Chakenahalli P.

    2016-05-01

    Full Text Available PURPOSE To correlate the sensitivity and specificity of High Resolution Computed Tomography (HRCT findings of temporal bone in chronic otitis media with surgical findings. MATERIALS & METHODS HRCT of temporal bone of fifty patients with chronic otitis media were evaluated prospectively between July 2012 and December 2013. The various pathological findings, complications and important anatomical variations were evaluated. These findings were compared with intraoperative findings. Statistical methods were carried out using SPSS for Windows (Version 16.0 and Minitab (Version 11.0 for windows. The sensitivity, specificity, false positive and false negative rates were calculated. The level of significance was considered significant for P-values <0.05. RESULTS HRCT is reliable for all the parameters like scutum erosion, ossicular erosion, mastoid pneumatisation, low lying dura, anterior lying sigmoid, Korner’s septum, cholesteatoma extension in middle ear and mastoid, and presence of complications like mastoiditis, mastoid abscess, mastoid cortex dehiscence, sigmoid sinus plate erosion, facial canal dehiscence, tegmen mastoideum erosion, labyrinthine fistula and intracranial complications with a P value <0.05 but not reliable for tegmen tympani erosion and posterior fossa dural plate erosion. Among the findings related to adjacent neurovascular structures, facial canal dehiscence was commonest followed by anterior lying sigmoid sinus and low lying dura. In ossicular erosion, incus was most commonly involved followed by stapes and malleus. Most of the mastoid in this study was sclerotic followed by pneumatised and diploic. The epitympanum and mastoid antrum were the most commonly involved areas in cholesteatoma followed by aditus, mastoid air cells, posterior tympanum, mesotympanum, hypotympanum, protympanum and perilabyrinthine air cells in decreasing order of frequency. CONCLUSIONS HRCT temporal bone is a reliable investigation in preoperative

  1. Human prostatic acid phosphatase directly stimulates collagen synthesis and alkaline phosphatase content of isolated bone cells

    Human prostatic acid phosphatase (hPAP) directly enhances the differentiated characteristics of isolated bone cells in vitro. This enzyme, when added to cell cultures for 24 h in vitro stimulates collagen synthesis and the production of alkaline phosphatase. The effects are dose dependent, with statistically significant effects occurring from 0.1-100 nM hPAP. Concentrations higher than 100 nM do not evoke greater effects. The maximal effect of hPAP occurs between 12 and 24 h of exposure. The cells stimulated to the greatest degree are osteoprogenitor cells and osteoblasts. Fibroblasts isolated from the same tissue show a lesser sensitivity to hPAP. hPAP has no detectable effect on cell proliferation, as measured by radiolabeled thymidine incorporation or total DNA synthesis. None of the observations reported in this work can be attributed to contaminating proteins in the hPAP preparation. hPAP was radiolabeled with 125I and was used for affinity binding and cross-linking studies. Scatchard analysis of specific binding indicated the presence of 1.0 X 10(5) high affinity binding sites/cell, with a Kd of 6.5 nM. Cross-linking studies demonstrated the presence of one 320-kDa binding complex. The pH profile and kinetic determinations of Km and maximum velocity for hPAP were similar to those previously reported, except for the finding of positive cooperativity of the substrate with the enzyme under the conditions of our assay. We believe that the direct stimulation of bone-forming cells by hPAP may contribute to the sclerotic nature of skeletal bone around sites of neoplastic prostatic metastases and that the effect of the enzyme is probably mediated by a plasma membrane receptor

  2. SADRŽAJ IZVJEŠĆA SENJSKO-MODRUŠKIH BISKUPA U RIM OD 1602. DO 1919. GODINE

    BOGOVIĆ, MILE

    1996-01-01

    U radu se donosi sadržaj izvješća senjsko-modruških biskupa u Rim od 1602. do 1919. Novija izvješća nisu u Tajnom vatikanskom arhivu dostupna istraživačima. Izvješća se nalaze u fondu Relationes ad limina voli. 734 i 799. Autor navodi imena znanstvenika koji su se bavili tom problematikom, imena biskupa koji su ta izvješća slali u Rim kao i njihov sadržaj na temelju kojega dobivamo detaljne i vrijedne podatke o stanju na području senjsko-modruške biskupije u tom razdoblju. Po njegovu mišljenj...

  3. A world perspective of the back-end fuel cycle and its significance for the Pacific rim countries

    There are currently two options available for the management of irradiated fuel. The first is reprocessing and recycle, and the second is the direct disposal of fuel following some form of storage and treatment. Interim storage is not an option but a deferral of the decision of which option to take. This paper identifies the major issues which are important in deciding on which option to follow and examines the possible implications for Pacific Rim Countries. Reprocessing and direct disposal are likely to remain complementary technologies for the foreseeable future, but it is the strategic significance of recycle that beckons with reduced dependence on energy imports within the Pacific Rim. This is challenged only by the perceptions of risks of and related attitudes to, nuclear weapons proliferation. This latter is a matter that can only be resolved at political level with international consensus

  4. Moldes protótipos para a produção de peças em RIM

    Silva, Marta Flora Araújo

    2008-01-01

    Dissertação de mestrado em Projecto e Fabrico de Moldes O presente relatório reporta a tese de mestrado, desenvolvida no âmbito do mestrado em Projecto e Fabrico de Moldes do Departamento de Engenharia de Polímeros da Universidade do Minho e tem como estudo central o desenvolvimento de moldes protótipos para a produção de peças em RIM. O tema da referida tese está não só relacionado com o mestrado em questão mas também surge no âmbito do desenvolvimento do projecto PerRIM. O...

  5. Catastrophic erosion of Hellas basin rim on Mars induced by magmatic intrusion into volatile-rich rocks

    Tanaka, K.L.; Kargel, J.S.; MacKinnon, D.J.; Hare, T.M.; Hoffman, N.

    2002-01-01

    Malea and Hesperia Plana form large sectors of the rim of Hellas basin that display partly eroded volcanic shields and plains. These regions have topographic profiles that appear to be several hundred meters lower than those of adjacent rim sectors and lack prominent massifs of remnant basement that would be expected to stand above the lava plains. We interpret that before the volcanic edifices were constructed, these regions were denuded by an early stage of voluminous sill intrusion into friable, volatile-rich impact breccia. Magma-volatile interactions may have resulted in catastrophic generation of debris flows deposited into the adjacent basin, particularly if CO2 were involved. Later, lavas covered the eroded terrain; in turn, the lavas were eroded locally by volatile interactions. Across Mars, huge channel systems, erosional features in volcanic terranes, and vast layered deposits may be due to magma-volatile interactions.

  6. A STUDY ON PREVALENCE OF DEPRESSION IN ATTEMPTED SUICIDE PATIENTS ATTENDING R.I.M.S . HOSPITAL, IMPHAL

    Hemchand Singh; Nirendrakumar Singh; Rameshwore Y

    2014-01-01

    OBJECTIVE: To evaluate prevalence of depression in individuals who attempted suicide and attended Regional Institute of Medical Sciences Hospital , Imphal. Method: The study was cross - sectional in which 50 patients who attempted suicide and attend ed RIMS Hospital and fulfilled the inclusion criteria were included in the study which was conducted from November 2005 to October 2006. A semi - structured interview schedule was used to find out the socio - ...

  7. Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation

    Sisodiya, S.M.; Thompson, P J; Need, A.; Harris, S.E.; M.E. Weale; Wilkie, S. E.; Michaelides, M.; Free, S.L.; Walley, N; Gumbs, C.; Gerrelli, D.; Ruddle, P.; Whalley, L.J.; Starr, J M; Hunt, D M

    2007-01-01

    Background: The genetic basis of variation in human cognitive abilities is poorly understood. RIMS1 encodes a synapse active- zone protein with important roles in the maintenance of normal synaptic function: mice lacking this protein have greatly reduced learning ability and memory function.Objective: An established paradigm examining the structural and functional effects of mutations in genes expressed in the eye and the brain was used to study a kindred with an inherited retinal dystrophy d...

  8. Initial Results of an Acetabular Center Axis Registration Technique in Navigated Hip Arthroplasty with Deformed Acetabular Rims

    Wada, Hiroshi; Mishima, Hajime; Yoshizawa, Tomohiro; Sugaya, Hisashi; Nishino, Tomofumi; Yamazaki, Masashi

    2016-01-01

    Background In cementless total hip arthroplasty, imageless computer-assisted navigation is usually used to register the anterior pelvic plane (APP). The accuracy of this method is influenced by the subcutaneous tissues overlying the registration landmarks. On the other hand, the acetabular center axis (ACA) is determined from the acetabular rim. Precise registration of the ACA is possible because of direct palpation using a pointer. Imageless navigation using the ACA usually targets patients ...

  9. Matsu Cultural Heritage and Its Conservation in Bohai Rim - Case Study on the Hall of Fujian in Yantai

    Yao, S.

    2015-08-01

    Since the Yuan Dynasty, the belief of Matsu had started to spread from the birthplace to the northern coastal areas in China. Matsu worship developed to the pinnacle with the official promotion on account of the government's dependence on grain transported by sea since the mid-Qing Dynasty. A large amount of Matsu temples emerged in coastal cities of Bohai Rim where it still keeps a large number of them until now. It has much relationship between the spread of Matsu culture and the flow of Fujian population. It was one of the main building way that the Matsu temples attached to the local hall of Fujian in Bohai Rim. The Hall of Fujian in Yantai, Which was built with materials taken from Fujian, in the feature of traditional architectural style from QuanZhou, is very different from the local building style of Yantai. This case indicates that maritime culture of the south area had spread and developed in the north areas under the promotion of the population flow and the economic transaction. The essay introduces briefly about the development of Matsu culture in Bohai Rim and takes the case study of the Hall of Fujian in Yantai analyzing its causes and features, and the value as Matsu heritage. Then the paper will discuss the conservation of Matsu culture mere include the tangible and the intangible culture heritage around the origin area, the heritages of the spread area also have the same importance significance. With the evolution of the society, it calls urgent attention and protection of Matsu culture in Bohai Rim.

  10. Combination of surgical excision and custom designed silicon pressure splint therapy for keloids on the helical rim

    Altmeyer Peter

    2007-03-01

    Full Text Available Abstract Keloids are defined as dermal fibrotic lesions which are considered an aberration of the wound healing process. Their etiology and pathogenesis are poorly understood. Different treatment modalities are described in the literature depending on the morphology and size of the keloid. We report a case of a large ear keloid on the helical rim which was successfully treated with surgery and a custom designed silicon pressure clip.

  11. The Rim101p/PacC pathway and alkaline pH regulate pattern formation in yeast colonies.

    Piccirillo, Sarah; White, Melissa G; Murphy, Jeffrey C; Law, Douglas J; Honigberg, Saul M

    2010-03-01

    Multicellular organisms utilize cell-to-cell signals to build patterns of cell types within embryos, but the ability of fungi to form organized communities has been largely unexplored. Here we report that colonies of the yeast Saccharomyces cerevisiae formed sharply divided layers of sporulating and nonsporulating cells. Sporulation initiated in the colony's interior, and this region expanded upward as the colony matured. Two key activators of sporulation, IME1 and IME2, were initially transcribed in overlapping regions of the colony, and this overlap corresponded to the initial sporulation region. The development of colony sporulation patterns depended on cell-to-cell signals, as demonstrated by chimeric colonies, which contain a mixture of two strains. One such signal is alkaline pH, mediated through the Rim101p/PacC pathway. Meiotic-arrest mutants that increased alkali production stimulated expression of an early meiotic gene in neighboring cells, whereas a mutant that decreased alkali production (cit1Delta) decreased this expression. Addition of alkali to colonies accelerated the expansion of the interior region of sporulation, whereas inactivation of the Rim101p pathway inhibited this expansion. Thus, the Rim101 pathway mediates colony patterning by responding to cell-to-cell pH signals. Cell-to-cell signals coupled with nutrient gradients may allow efficient spore formation and spore dispersal in natural environments. PMID:20038633

  12. Study of a bright-rimmed cloud at the border of the infrared dust bubble CN20

    Ortega, M. E.; Giacani, E.; Paron, S.; Rubio, M.

    2016-06-01

    We characterize an uncatalogued bright-rimmed cloud located at the border of the infrared dust bubble CN20 with the aim of investigating triggered star formation. In order to do this, we carried out radio continuum observations at 8.9 GHz using the Jansky Very Large Array (JVLA) interferometer with a synthesized beam size of 13 arcsec × 5 arcsec, and molecular observations using the Atacama Submillimeter Telescope Experiment (ASTE) at the 13CO J = 3-2 and CS J = 7-6 transitions. An analysis of the molecular observations and of Herschel public data revealed the presence of a warm and dense clump with Tdust ˜ 25 K and n(H2) ˜ 3 × 105 cm-3. The high angular resolution and sensitivity of the new radio continuum data revealed an arc-like radio filament in excellent correspondence with the illuminated border of the bright-rimmed cloud. This ionized boundary layer has an electron density of 176 cm-3. The spatial distribution of the young stellar object candidates probably related to the bright-rimmed cloud does not show clear evidence of a triggered origin. Finally, based on the evaluation of the pressure balance between the ionized and molecular gas, we conclude that the ionization front has stalled at the surface of the clump.

  13. The spatial-temporal evolution of aerosol optical depth and the analysis of influence factors in Bohai Rim

    Aerosol Optical Depth (AOD) is an important parameter of aerosol optical properties and it is an important physical parameter quantity to understanding the atmospheric environment. Bohai Rim is one of the three major urban agglomeration regions with rapidly developing economy in China. The study of AOD over this region is important to understand the environment and climate in Bohai Rim. Firstly, aerosol product data from 2000 to 2010, published by NASA, were used to analyze the temporal-spatial evolution of AOD in Bohai Rim with precision evaluation. The results showed that the spatial distribution of AOD had an obvious regional characteristic. The spatial distribution characterized that a much high value existed at urban areas and plain areas. On the contrary, the low value data existed in some mountainous regions which had higher percentages of forest coverage. The AOD values fluctuated somewhat each year in the region, from the minimum annual mean in 2003 to the maximum in 2009. Generally, the highest AOD value was in summer, followed by spring, autumn and winter. In terms of monthly variation, the value of AOD reached its peak in June and the lowest value was in December. This study analyzed the relation between AOD and some influence factors such as land use types, elevation, and distribution of urban agglomeration and so on. These results provide an important basic dataset for climate and environmental research

  14. RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast.

    Kessi-Pérez, Eduardo I; Araos, Sebastián; García, Verónica; Salinas, Francisco; Abarca, Valentina; Larrondo, Luis F; Martínez, Claudio; Cubillos, Francisco A

    2016-05-01

    Different natural yeast populations have faced dissimilar selective pressures due to the heterogeneous fermentation substrates available around the world; this increases the genetic and phenotypic diversity in Saccharomyces cerevisiae In this context, we expect prominent differences between isolates when exposed to a particular condition, such as wine or sake musts. To better comprehend the mechanisms underlying niche adaptation between two S. cerevisiae isolates obtained from wine and sake fermentation processes, we evaluated fermentative and fungicide resistance phenotypes and identify the molecular origin of such adaptive variation. Multiple regions were associated with fermentation rate under different nitrogen conditions and fungicide resistance, with a single QTL co-localizing in all traits. Analysis around this region identified RIM15 as the causative locus driving fungicide sensitivity, together with efficient nitrogen utilization and glycerol production in the wine strain. A null RIM15 variant confers a greater fermentation rate through the utilization of available glucose instead of its storage. However, this variant has a detrimental effect on fungicide resistance since complex sugars are not synthesized and transported into the membrane. Together, our results reveal the antagonist pleiotropic nature of a RIM15 null variant, positively affecting a series of fermentation related phenotypes, but apparently detrimental in the wild. PMID:26945894

  15. FIRST CALL FOR PAPERS The Second IEEE Pacific-Rim Conference on Multimedia

    2001-01-01

    Oct. 24~26, 2001, Beijing, China http://research.microsoft.com/~PCM2001. IEEE Signal Processing Society, IEEE Circuits and Systems Society National Science Foundation of China IEEE China, Electronics Society Of China, China Society of Electronics China Society of Computers, China Society of Image and Graphics   The second IEEE Pacific-Rim Conference on Multimedia will be held in Beijing in the next “golden autumn”. Beijing has been the culture capital of Chinese for near one thousand years with many historical palaces, magnificent museums and beautiful parks, as well as rich culture activities. In the last decade, Beijing has also witnessed spectacular growth of hi-tech industry, especially in the Internet and multimedia applications areas. The conference site, Zhongguangchun, known as China's Silicon Valley, is the national center of research, development and education with hundreds of universities and research institutions, and many successful companies providing both multimedia content and systems expertise. The conference complements this wonderful setting by providing a forum to presenting and exploring technological and artistic advancements in multimedia. Technical issues, theory and practice, artistic and consumer innovations will bring together researchers, artists, developers, educators, performers, and practitioners of multimedia from Pacific-Rim and the world. Present your work at PCM2001 and define the future of multimedia in the next millennium!   The technical program will feature keynote addresses, tutorials, special sessions, panels, technical demonstrations, in addition to technical presentations of refereed papers. We cordially invite you to submit your work in one or more of about forms for, but not limited to, the following three areas:   Multimedia processing and coding, including multimedia processing and compression, content analysis, content-based retrieval, watermarking and security;   Multimedia system support and

  16. Structural Studies of Eight Bright Rimmed Clouds in the Southern Hemisphere

    Sharma, Saurabh; Pandey, A. K.; Borissova, J.; Ojha, D. K.; Ivanov, V. D.; Ogura, K.; Kobayashi, N.; Kurtev, R.; Gopinathan, M.; Kesh Yadav, Ram

    2016-05-01

    We carried out deep- and wide-field near- and mid-infrared observations for a sample of eight bright-rimmed clouds (BRCs). Supplemented with the Spitzer archival data, we have identified and classified 44 to 433 young stellar objects (YSOs) associated with these BRCs. The Class I sources are generally located toward the places with higher extinction and are relatively closer to each other than the Class II sources, confirming that the young protostars are usually found in regions with denser molecular material. On the other hand the comparatively older population, Class II objects, are more randomly found throughout the regions, which can be due to their dynamical evolution. Using the minimal sampling tree analyses, we have extracted 13 stellar cores of eight or more members, which contain 60% of the total YSOs. The typical core is ∼0.6 pc in radii and somewhat elongated (aspect ratio of 1.45), of relatively low stellar density (surface density 60 pc‑2), consisting of a small (35) number of YSOs of relatively young sources (66% Class I), and partially embedded (median AK = 1.1 mag). But the cores show a wide range in their mass distribution (∼20 to 2400 M⊙), with a median value of around 130 M⊙. We found the star-formation efficiencies in the cores to be between 3% and 30% with an average of ∼14%, which agrees with the efficiencies needed to link the core mass function to the initial mass function. We also found a linear relation between the density of the clouds and the number of YSOs. The peaked nearest neighbor spacing distributions of the YSOs and the ratio of Jeans lengths to the YSO separations indicates a significant degree of non-thermally driven fragmentation in these BRCs.

  17. Initial Pancam Visible/Near-infrared Observations of Materials near Endeavour Crater's Western Rim

    Johnson, J. R.; Bell, J. F.; Farrand, W. H.; Wang, A.; MER Athena Science Team

    2011-12-01

    The Pancam multispectral stereo camera on the Opportunity Mars Exploration Rover began acquiring visible/near-infrared (443-1009 nm) images of materials along the western edge of Endeavour Crater in August, 2011. Preliminary observations documented changes in the color and textures of rocks and soils during the transition from typical Meridiani plains to the Endeavour rim area. As the rover approached Cape York and Spirit Point, Pancam observations (along with those from the Microscopic Imager) documented changes in size distributions of the ubiquitous hematite-rich spherules. For example, preliminary observations near the outcrop "Gibraltar" (north of the sand-filled 35 m diameter crater "Pathfinder") showed spherules embedded in the outcrop to be 5 mm (Figure 1). At the time of this writing, not all Pancam images of the Gibraltar area had been transmitted to the ground, but reflectance spectra from these observations will be presented at the meeting. Comparison of Pancam reflectance spectra to CRISM observations of the region also demonstrate the utility of orbital imaging spectroscopy as a means to guide rover traverses around Spirit Point during investigations of phyllosilicates-bearing materials. While Fe-bearing oxides and oxyhydroxides can exhibit distinctive spectral features in the visible/near-infrared, most diagnostic spectral features of phyllosilicate minerals are outside the spectral range of Pancam. Nonetheless, the potential exists for using Pancam for phyllosilicate-bearing rock detections, although they will be non-unique. For example, different classes of phyllosilicates (e.g., nontronite, montmorillonite) can be grouped to first order based on spectral parameters such as 900 nm band depth or reflectance maximum position vs. 535 nm band depth. Pancam observations relevant to these detections will be presented at the meeting.

  18. Ciclamato de sódio e rim fetal Sodium cyclamate and fetal kidney

    José Germano Ferraz de Arruda

    2003-06-01

    Full Text Available O ciclamato é usado como adoçante artificial não calórico em diversos alimentos e bebidas, sendo 30 vezes mais doce que a sacarose sem o sabor amargo da sacarina. Aparece na composição dos produtos como ciclamato de sódio, ciclamato de cálcio e ácido ciclâmico. O ciclamato e a ciclohexilamina, seu principal metabólito, atravessam a barreira placentária em humanos e desse modo podem ser expostos ao feto. O rim de ratos pode ser afetado por elevadas doses de ciclamato de sódio. Estudos sobre efeitos do ciclamato de sódio na espécie humana são necessários, pois, além de poder substituir a sacarose - prejudicial em casos de diabetes ou quando o controle e a redução do peso corporal são essenciais para a saúde dos pacientes - não propicia desenvolvimento de cárie dentária.Cyclamate is used as an artificial non-caloric sweetener in a variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It is present in the formula of products such as sodium and calcium cyclamates and cyclamic acid. Cyclamate and cyclohexylamine, its principal metabolite, can cross the human placenta exposing the fetus. It has been demonstrated in rats that the kidney may be adversely affected by high doses of cyclamate. Studies on the effects of sodium cyclamate in the human species are necessary, because in addition to replacing saccharose - harmful in individuals with diabetes or patients in whom weight reduction and control are essential for health - it does not cause dental caries.

  19. Bone tumors: Nursing care

    Bone tumors represent approximately 5% of childhood malignancies. osteosarcoma is the primary malignant bone tumor, accounting for 60% of cancer with peak incidence in the 2nd decade of life. Ewing's sarcoma is the second most common bone cancer with peak at a slightly younger age. This presentation discusses similarities and differences in the diagnosis and treatment of these two malignancies. Diagnostic procedures include plain radiographs, CT and MRI of the primary site, plain x-ray and CT of the chest, bone scan, and biopsy of the primary tumor. For patients diagnosed with Ewing's sarcoma, a bone marrow aspirate and biopsy will also be required. Our current approach to the treatment of bone tumors includes preoperative combination chemotherapy and en bloc surgical removal of the tumor followed by postoperative chemotherapy. In the case of Ewing's sarcoma, radiation therapy may be employed in addition to surgery, if margins are questionable of instead of surgery, if the tumor is not resectable

  20. Biophotonics and Bone Biology

    Zimmerli, Gregory; Fischer, David; Asipauskas, Marius; Chauhan, Chirag; Compitello, Nicole; Burke, Jamie; Tate, Melissa Knothe

    2004-01-01

    One of the more-serious side effects of extended space flight is an accelerated bone loss [Bioastronautics Critical Path Roadmap, http://research.hq.nasa.gov/code_u/bcpr/index.cfm]. Rates of bone loss are highest in the weight-bearing bones of the hip and spine regions, and the average rate of bone loss as measured by bone mineral density measurements is around 1.2% per month for persons in a microgravity environment. It shows that an extrapolation of the microgravity induced bone loss rates to longer time scales, such as a 2.5 year round-trip to Mars (6 months out at 0 g, 1.5 year stay on Mars at 0.38 g, 6 months back at 0 g), could severely compromise the skeletal system of such a person.

  1. Nanocomposites and bone regeneration

    James, Roshan; Deng, Meng; Laurencin, Cato T.; Kumbar, Sangamesh G.

    2011-12-01

    This manuscript focuses on bone repair/regeneration using tissue engineering strategies, and highlights nanobiotechnology developments leading to novel nanocomposite systems. About 6.5 million fractures occur annually in USA, and about 550,000 of these individual cases required the application of a bone graft. Autogenous and allogenous bone have been most widely used for bone graft based therapies; however, there are significant problems such as donor shortage and risk of infection. Alternatives using synthetic and natural biomaterials have been developed, and some are commercially available for clinical applications requiring bone grafts. However, it remains a great challenge to design an ideal synthetic graft that very closely mimics the bone tissue structurally, and can modulate the desired function in osteoblast and progenitor cell populations. Nanobiomaterials, specifically nanocomposites composed of hydroxyapatite (HA) and/or collagen are extremely promising graft substitutes. The biocomposites can be fabricated to mimic the material composition of native bone tissue, and additionally, when using nano-HA (reduced grain size), one mimics the structural arrangement of native bone. A good understanding of bone biology and structure is critical to development of bone mimicking graft substitutes. HA and collagen exhibit excellent osteoconductive properties which can further modulate the regenerative/healing process following fracture injury. Combining with other polymeric biomaterials will reinforce the mechanical properties thus making the novel nano-HA based composites comparable to human bone. We report on recent studies using nanocomposites that have been fabricated as particles and nanofibers for regeneration of segmental bone defects. The research in nanocomposites, highlight a pivotal role in the future development of an ideal orthopaedic implant device, however further significant advancements are necessary to achieve clinical use.

  2. Bone fractures after menopause

    Barlow, David H.; Bouchard, Philippe; Brandi, Maria Luisa; Evers, J.L.H.; Glasier, A.; Negri, Eva; Papapoulos, Socrates E; Ralston, Stuart H; Rizzoli, Rene; Baird, D T; Collins, J.; G. Benagiano; P.G. Crosignani; La Vecchia, C.; Volpe, A

    2010-01-01

    Every year 30% of individuals above age 65 fall, and falls are the principal cause of bone fractures. To reduce fracture incidence requires both prevention of falls and maintenance of bone strength.PubMed searches were performed, for studies of the epidemiology of fractures, bone physiology, endocrine effects, osteoporosis measurement, genetics, prevention and effectiveness. Topic summaries were presented to the Workshop Group and omissions or disagreements were resolved by discussion.Ageing ...

  3. Bone Regeneration in Odontostomatology

    Tonelli, P; Duvina, M.; Brancato, L.; Delle Rose, G.; Biondi, E.; Civitelli, V.

    2010-01-01

    Maxillary edentulism, together with periodontal disease, is the condition that most frequently induces disruption of alveolar bone tissue. Indeed, the stimulus of the periodontal ligament is lost and the local bone tissue becomes subject to resorption processes that, in the six months following the loss of the tooth, result in alveolar defects or more extensive maxillary atrophy. In both cases, loss of vestibular cortical bone is followed by reduction in the vertical dimension of the alveolar...

  4. Percutaneous Bone Tumor Management

    Gangi, Afshin; Buy, Xavier

    2010-01-01

    Interventional radiology plays a major role in the management of bone tumors. Many different percutaneous techniques are available. Some aim to treat pain and consolidate a pathological bone (cementoplasty); others aim to ablate tumor or reduce its volume (sclerotherapy, thermal ablation). In this article, image-guided techniques of primary and secondary bone tumors with vertebroplasty, ethanol injection, radiofrequency ablation, laser photocoagulation, cryoablation, and radiofrequency ioniza...

  5. Imaging of Bone Marrow.

    Lin, Sopo; Ouyang, Tao; Kanekar, Sangam

    2016-08-01

    Bone marrow is the essential for function of hematopoiesis, which is vital for the normal functioning of the body. Bone marrow disorders or dysfunctions may be evaluated by blood workup, peripheral smears, marrow biopsy, plain radiographs, computed tomography (CT), MRI and nuclear medicine scan. It is important to distinguish normal spinal marrow from pathology to avoid missing a pathology or misinterpreting normal changes, either of which may result in further testing and increased health care costs. This article focuses on the diffuse bone marrow pathologies, because the majority of the bone marrow pathologies related to hematologic disorders are diffuse. PMID:27444005

  6. Biophotonics and Bone Biology

    Zimmerli, Gregory; Fischer, David; Asipauskas, Marius; Chauhan, Chirag; Compitello, Nicole; Burke, Jamie; Tate, Melissa Knothe

    2004-01-01

    One of the more serious side effects of extended space flight is an accelerated bone loss. Rates of bone loss are highest in the weight-bearing bones of the hip and spine regions, and the average rate of bone loss as measured by bone mineral density measurements is around 1.2% per month for persons in a microgravity environment. It is well known that bone remodeling responds to mechanical forces. We are developing two-photon microscopy techniques to study bone tissue and bone cell cultures to better understand the fundamental response mechanism in bone remodeling. Osteoblast and osteoclast cell cultures are being studied, and the goal is to use molecular biology techniques in conjunction with Fluorescence Lifetime Imaging Microscopy (FLIM) to study the physiology of in-vitro cell cultures in response to various stimuli, such as fluid flow induced shear stress and mechanical stress. We have constructed a two-photon fluorescence microscope for these studies, and are currently incorporating FLIM detection. Current progress will be reviewed. This work is supported by the NASA John Glenn Biomedical Engineering Consortium.

  7. Bone marrow fat.

    Hardouin, Pierre; Pansini, Vittorio; Cortet, Bernard

    2014-07-01

    Bone marrow fat (BMF) results from an accumulation of fat cells within the bone marrow. Fat is not a simple filling tissue but is now considered as an actor within bone microenvironment. BMF is not comparable to other fat depots, as in subcutaneous or visceral tissues. Recent studies on bone marrow adipocytes have shown that they do not appear only as storage cells, but also as cells secreting adipokines, like leptin and adiponectin. Moreover bone marrow adipocytes share the same precursor with osteoblasts, the mesenchymal stem cell. It is now well established that high BMF is associated with weak bone mass in osteoporosis, especially during aging and anorexia nervosa. But numerous questions remain discussed: what is the precise phenotype of bone marrow adipocytes? What is the real function of BMF, and how does bone marrow adipocyte act on its environment? Is the increase of BMF during osteoporosis responsible for bone loss? Is BMF involved in other diseases? How to measure BMF in humans? A better understanding of BMF could allow to obtain new diagnostic tools for osteoporosis management, and could open major therapeutic perspectives. PMID:24703396

  8. Evaluation of sequential FDG-PET/CT for monitoring bone metastasis of breast cancer during therapy. Correlation between morphological and metabolic changes with tumor markers

    The purpose of this study was to clarify the significance of positron emission tomography (PET) and computed tomography (CT) findings for evaluating the bone metastasis of breast cancer during therapy. Forty-seven patients with bone metastases from breast cancer who underwent sequential 18F-flourodeoxyglucose (FDG)-PET/CT studies during therapy were enrolled. A total of 771 lesions were identified. The changes in the PET and CT findings were compared with the tumor marker levels in each patient by calculating the weighted kappa value. The correlation between the PET and CT findings was examined for each lesion by an adjusted Chi-square test. The change in the tumor marker levels was substantially correlated with the PET findings and moderately correlated with the CT findings (weighted kappa=0.780 and 0.585 for quadratic weighting, respectively). An increase in FDG uptake was correlated with lytic changes on the CT images (62/65, 95.4%, p<0.05). Sclerotic changes suggested improvement, but sclerosis and progression occurred at the same time in some lesions. Changes of FDG uptake are useful for evaluating individual bone metastases in cases of breast cancer during therapy. Lytic change on CT images suggests progression of bone metastasis. The lysis-progression/sclerosis-improvement pattern was observed in the majority of subjects, but a sclerosis-progression pattern was also observed. The hybrid pattern of increase of FDG uptake on PET/lytic change on CT is most accurate to show progression of bone metastases. Assessments of these processes during therapy are necessary for the precise evaluation of bone metastases. (author)

  9. Multiple soft tissue aneurysmal cysts: An occurrence after resection of primary aneurysmal bone cyst of fibula

    Karkuzhali P

    2007-01-01

    Full Text Available We report a case of multiple extraosseous aneurysmal cysts occurring in the muscle and subcutaneous plane of postero-lateral aspects of the upper right leg. They appeared about 15 months after resection of aneurysmal bone cyst of the upper end of the fibula. They varied in size from 2 cm to 5 cm. Radiologically they were well-defined lesions with central septate areas surrounded by a rim of calcification. Histologically they showed central cystic spaces separated by septa consisting of fibroblasts, osteoclast type of giant cells and reactive woven bone. Thus they showed histological similarity with aneurysmal bone cysts, but did not show any connection with the bone. Only very few examples of aneurysmal cysts of soft tissue had been described in the past one decade and they were reported in various locations including rare sites such as arterial wall and larynx. Recent cytogenetic analyses have shown abnormalities involving 17p11-13 and/or 16q22 in both osseous and extraosseous aneurysmal cysts indicating its probable neoplastic nature. Our case had unique features like multiplicity and occurrence after resection of primary aneurysmal bone cyst of the underlying bone.

  10. Extraskeletal and intraskeletal new bone formation induced by demineralized bone matrix combined with bone marrow cells

    Dilutions of fresh autogenous bone marrow cells in combination with allogeneic demineralized cortical bone matrix were tested extraskeletally in rats using roentgenographic, histologic, and 45Ca techniques. Suspensions of bone marrow cells (especially diluted 1:2 with culture media) combined with demineralized cortical bone seemed to induce significantly more new bone than did demineralized bone, bone marrow, or composite grafts with whole bone marrow, respectively. In a short-term spinal fusion experiment, demineralized cortical bone combined with fresh bone marrow produced new bone and bridged the interspace between the spinous processes faster than other transplantation procedures. The induction of undifferentiated host cells by demineralized bone matrix is further complemented by addition of autogenous, especially slightly diluted, bone marrow cells

  11. Temporal bone CT findings of tuberculous otitis media : comparison with chronic otitis media

    Chang, Jeong A; Rho, Myung Ho; Kim, Young Min; Lee, Ho Seung; Choi, Pil Yeob; Seong, Young Soon; Kwon, Jae Soo; Lee, Sang Wook [Masan Samsung Hospital, Sungkyunkwan Univ. College of Medicine, Seoul (Korea, Republic of); Jung, Keon Sik [Pohang Sunrin Hospital, Pohang (Korea, Republic of)

    1999-06-01

    To compare the differential findings of tuberculous otitis media(TOM) with those of chronic sup purative otitis media with or without cholesteatoma, as seen on high resolution temporal bone CT. We retrospectively reviewed 14 cases of TOM, 30 cases of chronic suppurative otitis media(CSOM), and 30 cases of chronic otitis media with cholesteatoma(Chole). All had been pathologically confirmed. We evaluated the preservation of mastoid cells without sclerotic change, the location and extension of soft tissue to the external auditary canal, and erosion of ossicles, the tegmen tympani, scutum, bony labyrinth, facial nerve canal and sigmoid sinus, and the presence of intracranial complications. Soft tissue in the mastoid antrum was seen in all cases of TOM(100%), 29 cases of CSOM(96.7%), and 26 cases of Chole(86.7%). In contrast, the soft tissue in the entire middle ear cavity was noted in 13 cases of TOM(92.8%), 7 cases of CSOM(23.3%), and 12 cases of Chole(40%). Soft tissue extended to the superior aspect of the external auditory canal in 4 cases of TOM (28.6%) and 5 cases of Chole (16.7%). Mastoid air cells were seen in 9 cases of TOM (64.3%), 4 cases of CSOM (13.3%), and 3 cases of Chole(10%). Ossicular erosion was noted in 6 cases of TOM (42.9%), 12 cases of CSOM (40%), and 26 cases of Chole(86.7%), while in one case of TOM (7.1%), 5 cases of CSOM (16.7%), and 15 cases of Chole(50%) there was erosion of the scutum. In one case of TOM, follow-up CT study after 9 months of antituberculous medication without surgery revealed complete clearing of previously noted soft tissue in the middle ear cavity. Specific CT findings of TOM were not seen, but if there were findings of soft tissue in the entire middle ear cavity, soft tissue extension to the external auditory canal, preservation of mastoid air cells without sclerotic change, and intact scutum, TOM may be differentiated from other chronic otitis media.

  12. Temporal bone CT findings of tuberculous otitis media : comparison with chronic otitis media

    To compare the differential findings of tuberculous otitis media(TOM) with those of chronic sup purative otitis media with or without cholesteatoma, as seen on high resolution temporal bone CT. We retrospectively reviewed 14 cases of TOM, 30 cases of chronic suppurative otitis media(CSOM), and 30 cases of chronic otitis media with cholesteatoma(Chole). All had been pathologically confirmed. We evaluated the preservation of mastoid cells without sclerotic change, the location and extension of soft tissue to the external auditary canal, and erosion of ossicles, the tegmen tympani, scutum, bony labyrinth, facial nerve canal and sigmoid sinus, and the presence of intracranial complications. Soft tissue in the mastoid antrum was seen in all cases of TOM(100%), 29 cases of CSOM(96.7%), and 26 cases of Chole(86.7%). In contrast, the soft tissue in the entire middle ear cavity was noted in 13 cases of TOM(92.8%), 7 cases of CSOM(23.3%), and 12 cases of Chole(40%). Soft tissue extended to the superior aspect of the external auditory canal in 4 cases of TOM (28.6%) and 5 cases of Chole (16.7%). Mastoid air cells were seen in 9 cases of TOM (64.3%), 4 cases of CSOM (13.3%), and 3 cases of Chole(10%). Ossicular erosion was noted in 6 cases of TOM (42.9%), 12 cases of CSOM (40%), and 26 cases of Chole(86.7%), while in one case of TOM (7.1%), 5 cases of CSOM (16.7%), and 15 cases of Chole(50%) there was erosion of the scutum. In one case of TOM, follow-up CT study after 9 months of antituberculous medication without surgery revealed complete clearing of previously noted soft tissue in the middle ear cavity. Specific CT findings of TOM were not seen, but if there were findings of soft tissue in the entire middle ear cavity, soft tissue extension to the external auditory canal, preservation of mastoid air cells without sclerotic change, and intact scutum, TOM may be differentiated from other chronic otitis media

  13. Accuracy evaluation of a new three-dimensional reproduction method of edentulous dental casts, and wax occlusion rims with jaw relation

    Yuan, Fu-Song; Sun, Yu-Chun; Wang, Yong; Lü, Pei-Jun

    2013-01-01

    The article introduces a new method for three-dimensional reproduction of edentulous dental casts, and wax occlusion rims with jaw relation by using a commercial high-speed line laser scanner and reverse engineering software and evaluates the method's accuracy in vitro. The method comprises three main steps: (i) acquisition of the three-dimensional stereolithography data of maxillary and mandibular edentulous dental casts and wax occlusion rims; (ii) acquisition of the three-dimensional stere...

  14. Bone X-Ray (Radiography)

    Full Text Available ... diagnosis of bone cancer . locate foreign objects in soft tissues around or in bones. top of page How ... Dense bone absorbs much of the radiation while soft tissue, such as muscle, fat and organs, allow more ...

  15. Bone X-Ray (Radiography)

    Full Text Available ... is commonly used to diagnose fractured bones or joint dislocation. Bone x-rays are the fastest and ... to view and assess bone fractures, injuries and joint abnormalities. This exam requires little to no special ...

  16. Bone X-Ray (Radiography)

    Full Text Available ... of bone cancer . locate foreign objects in soft tissues around or in bones. top of page How ... bone absorbs much of the radiation while soft tissue, such as muscle, fat and organs, allow more ...

  17. Bone X-Ray (Radiography)

    Full Text Available ... or in bones. top of page How should I prepare? Most bone x-rays require no special ... to 10 minutes. top of page What will I experience during and after the procedure? A bone ...

  18. Bone marrow (stem cell) donation

    ... this page: //medlineplus.gov/ency/patientinstructions/000839.htm Bone marrow (stem cell) donation To use the sharing ... stem cells from a donor's blood. Types of Bone Marrow Donation There are two types of bone ...

  19. Bone Marrow Aspiration and Biopsy

    ... Global Sites Search Help? Bone Marrow Aspiration and Biopsy Share this page: Was this page helpful? Also ... Examination Formal name: Bone Marrow Aspiration; Bone Marrow Biopsy Related tests: Complete Blood Count ; WBC Differential ; Reticulocyte ...

  20. Exercise for Your Bone Health

    ... supported by your browser. Home Bone Basics Lifestyle Exercise for Your Bone Health Publication available in: PDF ( ... A Complete Osteoporosis Program For Your Information Why Exercise? Like muscle, bone is living tissue that responds ...

  1. Wnt Signaling in Bone

    Kubota, Takuo; Michigami, Toshimi; Ozono, Keiichi

    2010-01-01

    Wnt signaling is involved not only in embryonic development but also in maintenance of homeostasis in postnatal tissues. Multiple lines of evidence have increased understanding of the roles of Wnt signaling in bone since mutations in the LRP5 gene were identified in human bone diseases. Canonical Wnt signaling promotes mesenchymal progenitor cells to differentiate into osteoblasts. The canonical Wnt/β-catenin pathway possibly through Lrp6, a co-receptor for Wnts as well as Lrp5, in osteoblasts regulates bone resorption by increasing the OPG/RANKL ratio. However, endogenous inhibitors of Wnt signaling including sclerostin block bone formation. Regulation of sclerostin appears to be one of the mechanisms of PTH anabolic actions on bone. Since sclerostin is almost exclusively expressed in osteocytes, inhibition of sclerostin is the most promising design. Surprisingly, Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum, but not by directly promoting bone formation. Pharmacological intervention may be considered in many components of the canonical Wnt signaling pathway, although adverse effects and tumorigenicity to other tissues are important. More studies will be needed to fully understand how the Wnt signaling pathway actually influences bone metabolism and to assure the safety of new interventions. PMID:23926379

  2. Bone marrow transplantation

    Peculiarities of clinico-hematologic pattern in patients with acute leukosis when ionizing radiation is used as prepration regime for hystocompatible bone marrow transplantation are listed. Chemico-radiopreparation of patients with acute leukosis is described, different techniques of bone marrow transplantation are presented, secondary signs of the disease are shown

  3. Rigidified calixarenes bearing four carbamoylmethylphosphineoxide or carbamoylmethylphosphoryl functions at the wide rim

    Arduini; Bohmer; Delmau; Desreux; Dozol; Carrera; Lambert; Musigmann; Pochini; Shivanyuk; Ugozzoli

    2000-06-16

    Conformationally rigidified tetraCMPO derivatives have been prepared from calix[4]arene bis(crown ether) 4a in which adjacent oxygens are bridged at the narrow rim by two diethylene glycol links. Acylation of the tetraamine 4c with the CMPO-active ester 5b gave the tetraphosphine oxide 6a, while the tetraphosphinate 6b and the tetraphosphonate 6c were obtained by Arbuzov reaction of tetrabromoacetamido derivative 7 with PhP(OEt)2 or P(OEt)3. The extraction ability of these CMPO derivatives was checked for selected lanthanides and actinides and compared with the analogous compounds 1b, 10b and 10d derived from calix[4]arene tetrapentyl ether. All rigidified bis(crown ether) ligands are more effective extractants than their pentyl ether counterparts and require only 1/10 of the concentration (cL= 10 4M) to obtain the same distribution coefficients, while with CMPO itself a 2,000-fold concentration is necessary. This could be a consequence of a better preorganisation of the ligating functions owing to the rigidity which on the other hand did not change the observed selectivity for americium (DAm/DEu=9-19) and for light lanthanides over heavy ones. NMR relaxivity titration curves show that the complex of Gd3+ with ligand 6a is highly oligomerised in anhydrous acetonitrile over a large range of ligand:metal concentration ratios. Nuclear magnetic relaxation dispersion (NMRD) profiles also showed that large oligomers were formed, and their mean tumbling times were deduced from the Solomon-Bloembergen-Morgan equations. The NMR spectra of dia- and paramagnetic lanthanide complexes with 6a agreed with the presence of two conformers with an elongated calix[4]arene skeleton in which the distances between opposite methylene groups are different. Contrary to what was observed with ligand 2a, the addition of nitrate ions does not labilize the metal complexes, presumably because of the rigidification effect of the ether bridges. Single-crystal X-ray structures were obtained for

  4. Development of high sensitive and reliable FFD and sodium leak detection technique for fast reactor using RIMS

    An early detection of fuel failure and subsequent precise identification of the failed fuel subassemblies are important and indispensable for operational safety of sodium cooled fast reactors. They help to prevent radioactive contamination in the primary cooling system, to reduce the personnel radiation dose and also to improve the plant availability factor as well. The artificially blended xenon and krypton gas (tag gas) is used as the failed fuel detection and location (FFDL) of the prototype fast breeder reactor Monju. The tag gas with different isotopic ratio was enclosed in each Monju fuel cladding tube and is measured by means of the mass spectrometry in the event of fuel failure. Since the tag gas released in the argon cover gas region is eventually diluted under the ppb level, it needs to concentrate at about 105 times using cryogenic charcoal bed which requires an elaborate operation and time. The high sensitive FFDL system is developed using laser resonance ionization mass spectrometry (RIMS) method. The RIMS is suitable for the isotope analysis of the element of ultra trace level, since there is no increase of the background by interfering ion and isobaric interference except for measuring element, because the measuring element is selectively ionized. Developed RIMS system (as shown) consists of the variable wavelength laser system with pulsed optical parametric oscillator and reflectron type time of flight mass spectrometer (RETOFMS). Employing a pulsed supersonic valve for sample gas injection enhanced the sensitivity. In order to suppress the unwanted peaks, the mass gating unit was adopted to prevent the argon ions from reaching the detector of RE-TOFMS. The RIMS was applied to measure the tag gas which is used for the pressurized steel capsule of on-line creep rupture experiment in the experimental fast reactor Joyo. As a result, this system could analyze the tag gas isotopic ratios of about 100 ∼102 ppb level and the measured results could

  5. The normal bone scan

    This paper discusses applications of the bone scan. It is the most frequently performed nuclear medicine investigation, the commonest indication being the detection of occult metastases, for which purpose the entire skeleton should be imaged. For other purposes it is often adequate to examine only part of the skeleton. The amount of isotope taken up at any site depends primarily on the local rate of bone turnover rather than on bone mass. The scintigraphic appearance therefore does not necessarily correlate with the radiographic one; however, as there is a relationship between the rate at which bone is replaced and the quantity of bone which is present at any point, the two appearances are not entirely unrelated. Recognition of abnormality is based on a detailed knowledge of normal scintigraphic appearances

  6. Bone markers and osteoporosis therapy

    Francisco Bandeira

    2014-07-01

    Full Text Available Several factors are involved in determining bone quality including bone density, bone turnover, the extent of trabecular bone connectivity, cortical porosity and geometry. Metabolically active and in a continuous process of remodeling, approximately 20% of bone tissue is renewed annually. Bone turn over markers (BTM are frequently used in clinical trials and to provide valid information about the effectiveness of osteoporosis treatment, reflecting the state of bone metabolism and its response to treatment, although they are not useful alone to estimate bone loss. In this review the behavior of BTM from different clinical trials or different osteoporotic drugs will be addressed.

  7. Bone scanning in osteoporosis

    This paper reports on bone scanning in osteoporosis a diagnosis of osteoporosis most often follows fracture, and clearly this should be confirmed by x-ray. The bone scan therefore does not have an important role to play in the initial diagnosis of osteoporosis. While the exact mechanism by which the 99mTc-labeled diphosphonates localize in the skeleton is not fully understood, it is believed that they adsorb onto bone surfaces most probably via the calcium of hydroxyapatite crystals. Because the major factors that affect adsorption are osteoblastic activity and to a lesser extent skeletal vascularity, it is apparent that a bone scan image presents a functional display of skeletal metabolic activity. However, osteoporosis is a disorder in which gradual change in bone mass may occur over many years and, in keeping with this minor imbalance in skeletal metabolism, the bone scan appearances are usually normal. However, the scan images may appear of poor quality because of relatively low bone uptake of tracer with, on occasion, a washed-out pattern of activity in the axial and appendicular bone. It has been suggested that such a pattern occurs in severe or end-stage osteoporosis caused by markedly reduced osteoblastic activity. If kyphosis is observed on the bone scan or if there appears to be loss of spinal height with proximity of ribs to each other or increased closeness of rib cage to pelvis, then appearances suggest vertebral collapse and would be in keeping with a diagnosis of osteoporosis. Such evidence is, however, indirect and in practice a bone scan is an extremely unreliable means of diagnosing osteoporosis

  8. Buyer's guide to telescopes at the best sites: Dome A, L2, and Shackleton Rim

    Angel, J. Roger P.

    2004-10-01

    Future optical/infrared telescopes will need to be much larger than today"s, if they are to address such key challenges as direct observations of Earth-like exoplanets and of the first stars formed after the big bang. In this paper I consider the most promising of the new sites, both on the ground and in space, and telescope concepts to take advantage of their complementary scientific potential. Ground based telescopes with adaptive optics will be capable of diffraction limited imaging, down to a short wavelength limit set by the amplitude and speed of the atmospheric turbulence. The best conditions are on the high Antarctic plateau, where recent measurements at Dome C show turbulence typically half the amplitude of the best temperate sites, with temporal evolution at half the speed1. Thus uniquely in Antarctica, diffraction limited imaging at optical wavelengths should be practical. Conditions there are also best for infrared astronomy, given the combination of minimal aberration and winter temperatures averaging as low as 200K at Dome A (the highest point). In space, well away from the warm Earth, conditions are even better, with 24 hour/day observing free from all atmospheric aberration, and the potential for passive cooling to 50K or less by use of a sunshield. L2 and the Moon's south pole are such optimal space locations. A telescope at L2 requires only a little fuel to stay on orbit, and can be accurately pointed despite solar torques by well established active methods based on star trackers, gyros and reaction wheels. By contrast, the Moon provides a completely stable platform where a telescope with no moving parts can remain pointed indefinitely along the spin axis, or a telescope on a hexapod mount can be oriented and tracked by reaction to the turning lunar surface. Solar shielding on the Moon requires a polar location such as the high rim of the Shackleton crater, adjacent to the south pole, where there is also nearly continuous solar power. Long term

  9. What Is a Bone Marrow Transplant?

    ... this page Print this page What is a bone marrow transplant? A bone marrow or cord blood transplant is ... with healthy bone marrow. Tweet What is a bone marrow transplant How a bone marrow transplant works Transplant process ...

  10. Feasibility and safety of transthoracic echocardiography-guided transcatheter closure of atrial septal defects with deficient superior-anterior rims.

    Li, Gui-Shuang; Li, Hai-De; Yang, Jie; Zhang, Wen-Quan; Hou, Zong-Shen; Li, Qing-Chen; Zhang, Yun

    2012-01-01

    Although previous studies showed that transthoracic echocardiography (TTE) can be used to guide transcatheter closure of atrial septal defect (ASD), whether TTE can be used to guide transcatheter closure of secundum ASD with a deficient superior-anterior rim is unknown and this critical issue was addressed in the present study. A total of 280 patients with secundum ASD who underwent transcatheter ASD closure were recruited and divided into groups A and B depending on ASD superior-anterior rim>4 mm (n = 118) or ≤4 mm (n = 162). TTE was used to guide Amplatzer-type septal occluder (ASO) positioning and assess residual shunt. Procedure success was defined as no, trivial and small residual shunt immediately after the procedure as assessed by color Doppler flow imaging. Group A and group B did not differ in complication rate (8.55% vs.7.55%), procedure success rate (98.3% vs. 95.0%) or complete closure rate immediately after the procedure (89.7% vs. 89.3%) or at 6-month follow-up (98.3% vs. 96.8%). The mean procedure and fluoroscopy time in group B were much longer than those in group A. In conclusion, the absence of a sufficient superior-anterior rim in patients undergoing percutaneous closure of secundum-type ASDs using fluoroscopic and TTE guidance is associated with slightly greater device malposition and migration as well as increased procedural and fluoroscopic times, but the overall complication rate did not differ with TTE guidance when compared to historical controls that used TEE guidance. PMID:23284660

  11. Feasibility and safety of transthoracic echocardiography-guided transcatheter closure of atrial septal defects with deficient superior-anterior rims.

    Gui-Shuang Li

    Full Text Available Although previous studies showed that transthoracic echocardiography (TTE can be used to guide transcatheter closure of atrial septal defect (ASD, whether TTE can be used to guide transcatheter closure of secundum ASD with a deficient superior-anterior rim is unknown and this critical issue was addressed in the present study. A total of 280 patients with secundum ASD who underwent transcatheter ASD closure were recruited and divided into groups A and B depending on ASD superior-anterior rim>4 mm (n = 118 or ≤4 mm (n = 162. TTE was used to guide Amplatzer-type septal occluder (ASO positioning and assess residual shunt. Procedure success was defined as no, trivial and small residual shunt immediately after the procedure as assessed by color Doppler flow imaging. Group A and group B did not differ in complication rate (8.55% vs.7.55%, procedure success rate (98.3% vs. 95.0% or complete closure rate immediately after the procedure (89.7% vs. 89.3% or at 6-month follow-up (98.3% vs. 96.8%. The mean procedure and fluoroscopy time in group B were much longer than those in group A. In conclusion, the absence of a sufficient superior-anterior rim in patients undergoing percutaneous closure of secundum-type ASDs using fluoroscopic and TTE guidance is associated with slightly greater device malposition and migration as well as increased procedural and fluoroscopic times, but the overall complication rate did not differ with TTE guidance when compared to historical controls that used TEE guidance.

  12. ULTRASONIC EVALUATION OF STRESS STATES OF RIMS OF RAILROAD WHEELS. PART 2 — EXPERIENCES AND FUTURE ADAPTATIONS

    Schneider, E.; DYMKIN G.

    2013-01-01

    An ultrasonic technique was developed and different systems are in use to evaluate the stress state of the rim of solid railroad wheels. The measure results received with the UER system versions developed by IZFP as well as the Russian version УКОН-01 was shown and described in the paper. Because the stress state of new wheels is smaller in value than the stress in braked wheels, the influence of a slightly developed texture in new wheels cannot be neglected as it can in case of used wheels. ...

  13. Synthesis and cationic selectivity studies of novel calix[4]arene derivatives containing heteroatom at the lower rim

    2007-01-01

    A series of calixarene derivatives 2-5 containing heteroatom at the lower rim have been synthesized. 1H NMR studies and crystallographic structures demonstrated that the calix[4]arene derivatives adopted cone conformations. Their cationic binding abilities and selectivities towards heavy and transition metal ions have been evaluated by solvent extraction of aqueous metal picrates. The obtained results indicated that the introduction of nitrogen, sulfur, and/or phosphor atoms to the calix[4]arene framework could effectively enhance their binding ability and selectivity for heavy and transition metal ions, such as Pb2+ or Ag+.

  14. Airborne measurements and emission estimates of greenhouse gases and other trace constituents from the 2013 California Yosemite Rim wildfire

    Yates, E. L.; Iraci, L. T.; Singh, H. B.; Tanaka, T.; Roby, M. C.; Hamill, P.; Clements, C. B.; Lareau, N.; Contezac, J.; Blake, D. R.; Simpson, I. J.; Wisthaler, A.; Mikoviny, T.; Diskin, G. S.; Beyersdorf, A. J.; Choi, Y.; Ryerson, T. B.; Jimenez, J. L.; Campuzano-Jost, P.; Loewenstein, M.; Gore, W.

    2016-02-01

    This paper presents airborne measurements of multiple atmospheric trace constituents including greenhouse gases (such as CO2, CH4, O3) and biomass burning tracers (such as CO, CH3CN) downwind of an exceptionally large wildfire. In summer 2013, the Rim wildfire, ignited just west of the Yosemite National Park, California, and burned over 250,000 acres of the forest during the 2-month period (17 August to 24 October) before it was extinguished. The Rim wildfire plume was intercepted by flights carried out by the NASA Ames Alpha Jet Atmospheric eXperiment (AJAX) on 29 August and the NASA DC-8, as part of SEAC4RS (Studies of Emissions, Atmospheric Composition, Clouds and Climate Coupling by Regional Surveys), on 26 and 27 August during its intense, primary burning period. AJAX revisited the wildfire on 10 September when the conditions were increasingly smoldering, with slower growth. The more extensive payload of the DC-8 helped to bridge key measurements that were not available as part of AJAX (e. g. CO). Data analyses are presented in terms of emission ratios (ER), emission factors (EF) and combustion efficiency and are compared with previous wildfire studies. ERs were 8.0 ppb CH4 (ppm CO2)-1 on 26 August, 6.5 ppb CH4 (ppm CO2)-1 on 29 August and 18.3 ppb CH4 (ppm CO2)-1 on 10 September 2013. The increase in CH4 ER from 6.5 to 8.0 ppb CH4 (ppm CO2)-1 during the primary burning period to 18.3 ppb CH4 (ppm CO2)-1 during the fire's slower growth period likely indicates enhanced CH4 emissions from increased smoldering combustion relative to flaming combustion. Given the magnitude of the Rim wildfire, the impacts it had on regional air quality and the limited sampling of wildfire emissions in the western United States to date, this study provides a valuable dataset to support forestry and regional air quality management, including observations of ERs of a wide number of species from the Rim wildfire.

  15. The application and implementation of optimized mine ventilation on demand (OMVOD) at the Xstrata Nickel Rim South Mine, Sudbury, Ontario

    An Optimized Mine Ventilation on Demand (OMVOD) system has been installed at the Xstrata Nickel Rim South Mine in Sudbury. Developed by Simsmart Technologies, the OMVOD system monitors and controls air quality and quantity through real time dynamic automation. A ventilation on demand (VOD) system was needed to remove diesel particulate matter (DPM), carbon monoxide (CO) and nitrogen dioxide (NO2). This paper described the real-time tracking and monitoring of the OMVOD system and optimization of ventilation equipment. Simsmart's OMVOD system was shown to reduce energy costs while improve air quality in the underground mine. 7 refs., 3 tabs., 8 figs.

  16. Design optimization of a slotless PM brushless motor with helical edge wound laminations for rim driven thrusters

    Sharkh, S.M.; Lai, S. H.

    2010-01-01

    This paper discusses the analysis and design of a very thin slotless PM brushless motor whose stator laminations are manufactured from a single strip of steel that is edge wound into a spiral (like a “Slinky”) and then fitted over the windings that are preformed on the outside surface of a non-conducting former. Analytical and finite element analysis (FEA) are used to determine the constrained optimum dimensions of a motor used to drive a rim driven thruster in which the motor rotor is fitted...

  17. Computer Calculations of Eddy-Current Power Loss in Rotating Titanium Wheels and Rims in Localized Axial Magnetic Fields

    Mayhall, D J; Stein, W; Gronberg, J B

    2006-05-15

    We have performed preliminary computer-based, transient, magnetostatic calculations of the eddy-current power loss in rotating titanium-alloy and aluminum wheels and wheel rims in the predominantly axially-directed, steady magnetic fields of two small, solenoidal coils. These calculations have been undertaken to assess the eddy-current power loss in various possible International Linear Collider (ILC) positron target wheels. They have also been done to validate the simulation code module against known results published in the literature. The commercially available software package used in these calculations is the Maxwell 3D, Version 10, Transient Module from the Ansoft Corporation.

  18. Pathogenetic differentiation of the bone superscan using bone marrow scintigraphy

    The case of a 54-year old patient suffering from a prostatic carcinoma is presented. At the time of diagnosis multiple bone metastases were detected by bone scintigraphy. An initial improvement was observed following antiandrogenic therapy. After three years the patient presented with increasing bone pain, which was most prominent in the knee joints. A 'superscan' was found in bone scintigraphy with an unusually high uptake in the peripheral skeleton. Bone marrow scintigraphy showed a nearly complete metastatic displacement of central bone marrow and a peripheral marrow extension as explanation for the bone scan findings. (orig.)

  19. Inhibitory Role of Greatwall-Like Protein Kinase Rim15p in Alcoholic Fermentation via Upregulating the UDP-Glucose Synthesis Pathway in Saccharomyces cerevisiae.

    Watanabe, Daisuke; Zhou, Yan; Hirata, Aiko; Sugimoto, Yukiko; Takagi, Kenichi; Akao, Takeshi; Ohya, Yoshikazu; Takagi, Hiroshi; Shimoi, Hitoshi

    2016-01-01

    The high fermentation rate of Saccharomyces cerevisiae sake yeast strains is attributable to a loss-of-function mutation in the RIM15 gene, which encodes a Greatwall-family protein kinase that is conserved among eukaryotes. In the present study, we performed intracellular metabolic profiling analysis and revealed that deletion of the RIM15 gene in a laboratory strain impaired glucose-anabolic pathways through the synthesis of UDP-glucose (UDPG). Although Rim15p is required for the synthesis of trehalose and glycogen from UDPG upon entry of cells into the quiescent state, we found that Rim15p is also essential for the accumulation of cell wall β-glucans, which are also anabolic products of UDPG. Furthermore, the impairment of UDPG or 1,3-β-glucan synthesis contributed to an increase in the fermentation rate. Transcriptional induction of PGM2 (phosphoglucomutase) and UGP1 (UDPG pyrophosphorylase) was impaired in Rim15p-deficient cells in the early stage of fermentation. These findings demonstrate that the decreased anabolism of glucose into UDPG and 1,3-β-glucan triggered by a defect in the Rim15p-mediated upregulation of PGM2 and UGP1 redirects the glucose flux into glycolysis. Consistent with this, sake yeast strains with defective Rim15p exhibited impaired expression of PGM2 and UGP1 and decreased levels of β-glucans, trehalose, and glycogen during sake fermentation. We also identified a sake yeast-specific mutation in the glycogen synthesis-associated glycogenin gene GLG2, supporting the conclusion that the glucose-anabolic pathway is impaired in sake yeast. These findings demonstrate that downregulation of the UDPG synthesis pathway is a key mechanism accelerating alcoholic fermentation in industrially utilized S. cerevisiae sake strains. PMID:26497456

  20. Bone cancer risk

    In view of the considerable disparity in published values of the risk for bone cancers from ionising radiation, the article 'An analysis of bone and head sinus cancers in radium dial painters using a two-mutation carcinogenesis model' by Leenhouts and Brugmans in the June 2000 issue of this Journal deserves further comment and consideration. The letter concludes that radiological protection and risk estimation has acquired an extra dimension, and it is clear that the risk of bone cancer from exposure to ionising radiation needs further review. Letter-to-the-editor

  1. Periodontal bone lesions

    In the course of life the periodontum is subject to changes which may be physiological or pathological. Intraoral radiographs give insight into the hard structures of the dentomaxillar region and provides information on lesions in the bone of the periodontum in that they show radiopacities and radiolucencies caused by such lesions. In this thesis the relation is investigated between the true shape and dimensions of periodontal bone lesions and their radiographic images. A method is developed and tested of making standardized and reproducible radiographs suitable for longitudinal studies of periodontal lesions. Also the possibility is demonstrated of an objective and reproducible interpretation of radiographic characteristics of periodontal bone lesions. (Auth.)

  2. Enzymatic maceration of bone

    Uhre, Marie-Louise; Eriksen, Anne Marie; Simonsen, Kim Pilkjær;

    2015-01-01

    This proof of concept study investigates the removal of soft tissue from human ribs with the use of two common methods: boiling with a laundry detergent and using enzymes. Six individuals were autopsied, and one rib from each individual was removed for testing. Each rib was cut into pieces and...... the bones. The DNA analysis showed that DNA was preserved on all the pieces of bones which were examined. Finally, the investigation suggests that enzyme maceration could be gentler on the bones, as the edges appeared less frayed. The enzyme maceration was also a quicker method; it took three hours...

  3. Why date old bones?

    The methods for pretreatment and purification of bone have not been accorded the same standard protocols that are applied to other sample materials. Many users lack confidence in bone dates, with some justification, and it is not clear how to proceed. With the advent of AMS dating, it is becoming easy to date very small amounts of highly purified samples such as single amino acids from bone collagen. This note serves a warning that there are dangers in the uncritical application of powerful separation and measurement techniques to uncharacterized material. (orig.)

  4. Bone scintigraphy for horses

    Scintigraphy (bone scan) is being used approximately since 1980 in the horse under general anaesthesia. With the construction of custom-made overhead gantries for gamma-cameras scintigraphy found widespread entry in big equine referral hospitals for bone-scanning of the standing horse. Indications for the use of a bone scan in the horse are inflammatory alterations in the locomotor apparatus. It is primarily used for diagnosis of lameness of unknown origin, suspect of stress fracture or hairline fracture and for horses with bad riding comfort with suspected painful lesions in the spine. (orig.)

  5. 2011 Tohoku Earthquake and Japan's Nuclear Disaster - Implications for Indian Ocean Rim countries

    Chadha, R. K.

    2011-12-01

    The Nuclear disaster in Japan after the M9.0 Tohoku earthquake on March 11, 2011 has elicited global response to have a relook at the safety aspects of the nuclear power plants from all angles including natural hazards like earthquakes and tsunami. Several countries have gone into safety audits of their nuclear programs in view of the experience in Japan. Tectonically speaking, countries located close to subduction zones or in direct line of impact of the subduction zones are the most vulnerable to earthquake or tsunami hazard, as these regions are the locale of great tsunamigenic earthquakes. The Japan disaster has also cautioned to the possibility of great impact to the critical structures along the coasts due to other ocean processes caused by ocean-atmosphere interactions and also due to global warming and sea level rise phenomena in future. This is particular true for island countries. The 2011 Tohoku earthquake in Japan will be remembered more because of its nuclear tragedy and tsunami rather than the earthquake itself. The disaster happened as a direct impact of a tsunami generated by the earthquake 130 km off the coast of Sendai in the Honshu region of Japan. The depth of the earthquake was about 25 km below the ocean floor and it occurred on a thrust fault causing a displacement of more than 20 meters. At few places, water is reported to have inundated areas up to 8-10 km inland. The height of the tsunami varied between 10 and 3 meters along the coast. Generally, during an earthquake damage to buildings or other structures occur due to strong shaking which is expressed in the form of ground accelerations 'g'. Although, Peak Ground Accelerations (PGA) consistently exceeded 2g at several places from Sendai down south, structures at the Fukushima Daiichi Nuclear Power Plant did not collapse due to the earthquake. In the Indian Ocean Rim countries, Indian, Pakistan and South Africa are the three countries where Nuclear power plants are operational, few of them

  6. A CLINICAL STUDY ON LENS INDUCED GLAUCOMA AND ITS VISUAL OUTCOME IN PATIENTS VISITING RIMS, SRIKAKULAM

    Rajkumar

    2015-07-01

    Full Text Available AIM: To Evaluate sex predominance, prevalence of different types of lens induced Glaucomas and its visual outcomes in patients visiting rims, srikakulam. MATERIAL AND METHODS : This prospective study was conducted in Ophthalmology department of Rajiv Gandhi Institute of Medical Sciences, Srikakulam, Andhra Pradesh from October 2014 to June 2015. 37 Patients visiting the Hospital with classical symptoms of Lens induced Glaucoma were taken into study. First all these patients underwent a through ocular examination using Slit lamp biomicroscopy, Schiotz tonometry and Applanation tonometer. T hese patients were operated after explaining the possible prognosis, by Small Incision Cataract Surgery with PCIOL implantation. Also a peripheral Iridectomy was performed to all the patients. Post operatively immense care was taken to prevent posterior synechiae formation using short acting Cycloplegics. During follow up a detailed Ocular examination was done including Refraction using snellens chart and IOP measurement using Schiotz tonometer and applanation tomometer. All the results were entered in Computer and evaluated. RESULTS: A Total of 37 patients were taken into this study in which 14(37.84% were male patients and 23(62.16% were Female. Among different LIG patients maximum patients had Phacomorphic Glaucoma accounting 67.57% (25 patients and Phacolytic Glaucoma 29.73%. Intra Ocular pressure was measured on admission before any medication and noted. Highest percentage was among 30 - 39mmHg (37.84% followed by 40 - 49mmHg (32.43% and 50 - 59mmHg (16.22%. After surgery during discharge all those patients were measured again for IOP and noted. Highest patients were between 10 - 19mmHg (78.38%. Rest were <10(10.8%. Similarly Visual acuity o n admission, highest patients were seen in Hand movements positive (37.84% followed by Perception of Light positive (29.73%. Even No PL were also seen (16.22% in higher proportion. On the day of follow up after 2 weeks

  7. Acidic microenvironment and bone pain in cancer-colonized bone

    Yoneda, Toshiyuki; Hiasa, Masahiro; Nagata, Yuki; Okui, Tatsuo; White, Fletcher A.

    2015-01-01

    Solid cancers and hematologic cancers frequently colonize bone and induce skeletal-related complications. Bone pain is one of the most common complications associated with cancer colonization in bone and a major cause of increased morbidity and diminished quality of life, leading to poor survival in cancer patients. Although the mechanisms responsible for cancer-associated bone pain (CABP) are poorly understood, it is likely that complex interactions among cancer cells, bone cells and periphe...

  8. Bone X-Ray (Radiography)

    Full Text Available ... Professions Site Index A-Z X-ray (Radiography) - Bone Bone x-ray uses a very small dose ... limitations of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is ...

  9. Interparietal bones in Nigerian skulls.

    Saxena, S. K.; Chowdhary, D S; Jain, S P

    1986-01-01

    The study was conducted on 40 adult Nigerian skulls which were examined for the presence of interparietal and pre-interparietal bones. Only one interparietal bone was found (2.5% of the present series) while a single pre-interparietal bone was found in four skulls (10%) and multiple pre-interparietal bones in one skull (2.5%).

  10. Bone X-Ray (Radiography)

    Full Text Available ... News Physician Resources Professions Site Index A-Z X-ray (Radiography) - Bone Bone x-ray uses a very ... of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive ...

  11. Bone X-Ray (Radiography)

    ... News Physician Resources Professions Site Index A-Z X-ray (Radiography) - Bone Bone x-ray uses a very ... of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive ...

  12. Can bone scintigraphy predict the final outcome of pasteurized autografts?

    Eid, Ahmed Shawky [Ain Shams University, Department of Orthopedic Surgery, Cairo (Egypt); Jeon, Dae-Geun; Cho, Wan Hyeong [Korea Cancer Center Hospital, Department of Orthopedic Surgery, Seoul (Korea)

    2010-10-15

    As pasteurization is becoming more widely used in limb salvage reconstruction, more study is required to understand about host-graft junction healing, graft revascularization and incorporation, and the incidence and type of complications among pasteurized autografts. This was mainly achieved by follow-up radiography. We aimed to clarify whether Tc99m bone scanning can be considered a reliable method in determining these three parameters. Twenty-seven osteosarcoma patients with pasteurized autograft reconstructions were retrospectively reviewed using available scintigraphic and radiographic follow-up every 6 months postoperatively for 36 months. Follow-up of the unhealed cases was continued for the maximum follow-up period available for each case beyond the original study period, ranging from 1 to 15 months. Tc99m uptake was classified as cold, faint, moderate and high uptake. Junction healing was classified as none, partial and complete healing. Seventy percent of junctions united with a mean of 22 months. Ninety to 100% of junctions showed increased uptake (high or moderate) at one time of the study regardless of final outcome. 85% of the pasteurized grafts showed the characteristic ''tramline appearance''. Four grafts (15%) were complicated: pseudoarthrosis and implant failure (1), fractured plate (1), intramedullary nail (IMN) fracture (1), and prosthesis stem loosening in the host bone (1), with underlying unhealed junctions in all cases. Bone scanning can determine the stages of the graft's rim revascularization and incorporation; however, it cannot detect or predict junction healing or occurrence of complications. Supplementary treatment of unhealed junctions showing either decreased junctional uptake or graft quiescence may be warranted. Otherwise, detection of distant metastasis and early local recurrence remains the main application of Tc99m scanning in the management of bone sarcomas. (orig.)

  13. Immunoregulation of bone remodelling

    Singh, Ajai; Mehdi, Abbass A; Srivastava, Rajeshwer N; Verma, Nar Singh

    2012-01-01

    Remodeling, a continuous physiological process maintains the strength of the bones, which maintains a delicate balance between bone formation and resorption process. This review gives an insight to the complex interaction and correlation between the bone remodeling and the corresponding changes in host immunological environment and also summarises the most recent developments occuring in the understanding of this complex field. T cells, both directly and indirectly increase the expression of receptor activator of nuclear factor kB ligand (RANKL); a vital step in the activation of osteoclasts, thus positively regulates the osteoclastogenesis. Though various cytokines, chemikines, transcription factors and co-stimulatory molecules are shared by both skeletal and immune systems, but researches are being conducted to establish and analyse their role and / or control on this complex but vital process. The understanding of this part of research may open new horizons in the management of inflammatory and autoimmune diseases, resulting into bone loss and that of osteoporosis also. PMID:22837895

  14. Proximal Tibial Bone Graft

    ... Complications Potential problems after a PTBG include infection, fracture of the proximal tibia and pain related to the procedure. Frequently Asked Questions If proximal tibial bone graft is taken from my knee, will this prevent me from being able to ...

  15. Osteomyelitis of frontal bone

    Chaturvedil, V. N.; Raizada, R. M.; Singh, A. K. Kennedy; Puttewar, M. P.; Bali, S.

    2004-01-01

    A case of Osteomyelitis of the frontal bone with a subperiosteal absces s, an extrudural abscess and a frontal sinus fistula is presented here for its rarity. A brief review of literature and management of the condition is also discussed.

  16. Mesoscale Raised Rim Depressions (MRRDs) on Earth: A Review of the Characteristics, Processes, and Spatial Distributions of Analogs for Mars

    Burr, Devon M.; Bruno, Barbara C.; Lanagan, Peter D.; Glaze, Lori; Jaeger, Windy L.; Soare, Richard J.; Tseung, Jean-Michel Wan Bun; Skinner, James A. Jr.; Baloga, Stephen M.

    2008-01-01

    Fields of mesoscale raised rim depressions (MRRDs) of various origins are found on Earth and Mars. Examples include rootless cones, mud volcanoes, collapsed pingos, rimmed kettle holes, and basaltic ring structures. Correct identification of MRRDs on Mars is valuable because different MRRD types have different geologic and/or climatic implications and are often associated with volcanism and/or water, which may provide locales for biotic or prebiotic activity. In order to facilitate correct identification of fields of MRRDs on Mars and their implications, this work provides a review of common terrestrial MRRD types that occur in fields. In this review, MRRDs by formation mechanism, including hydrovolcanic (phreatomagmatic cones, basaltic ring structures), sedimentological (mud volcanoes), and ice-related (pingos, volatile ice-block forms) mechanisms. For each broad mechanism, we present a comparative synopsis of (i) morphology and observations, (ii) physical formation processes, and (iii) published hypothesized locations on Mars. Because the morphology for MRRDs may be ambiguous, an additional tool is provided for distinguishing fields of MRRDs by origin on Mars, namely, spatial distribution analyses for MRRDs within fields on Earth. We find that MRRDs have both distinguishing and similar characteristics, and observation that applies both to their mesoscale morphology and to their spatial distribution statistics. Thus, this review provides tools for distinguishing between various MRRDs, while highlighting the utility of the multiple working hypotheses approach.

  17. Skull base bone hyperpneumatization

    Houet, E J; Kouokam, L.M.; Nchimi, A L

    2013-01-01

    A 50-year-old male with a long standing history of compulsive Valsalva maneuvers, complaining of episodes of vertigo underwent head computed tomography. Axial CT slices at the level of the skull base (Fig. A) and the first cervical vertebrae (Fig. B) shows an extensive unusual pneumatization of both the body and lateral processes of the first cervical vertebrae (arrows), with air pouches dissecting planes between bone cortex and the periosteum around the occipital bone and the lateral process...

  18. Inca bones at asterion

    Prashant E Natekar; Suhit E Natekar; Fatima M De Souza

    2014-01-01

    Background: Surgical approach towards asterion has to be done with caution as many surgeons are unfamiliar with the anatomical variations. The asterion corresponds to the site of the posterolateral (mastoid) fontanelle of the neonatal skull which closes at the end of the first year. Inca bones provide information as markers for various diseases, and can mislead in the diagnosis of fractures. Observation and Results: 150 dry skull bones from the Department of Anatomy at Goa Medical College, In...

  19. Uranium in fossil bones

    An attempt has been made to determine the uranium content and thus the age of certain fossil bones Haritalyangarh (Himachal Pradesh), India. The results indicate that bones rich in apatite are also rich in uranium, and that the radioactivity is due to radionuclides in the uranium series. The larger animals apparently have a higher concentration of uranium than the small. The dating of a fossil jaw (elephant) places it in the Pleistocene. (Auth.)

  20. Bone healing: little secrets

    Einhorn, T. A.

    2011-01-01

    The development of new strategies to enhance the healing of fractures continues to evolve with the introduction of both locally and systemically delivered compounds. The recent refinement in the use of autologous bone marrow as a bone graft material has brought the field of stem cell biology into orthopaedic practice. New recombinant peptides such as platelet- derived growth factor and teriparatide show promise as local and systemic enhancers respectively. Finally, recent evidence that mutati...

  1. Detecting microdamage in bone.

    Lee, T Clive; Mohsin, Sahar; Taylor, David; Parkesh, Raman; Gunnlaugsson, TThorfinnur; O'Brien, Fergal J.; Giehl, Michael; Gowin, Wolfgang

    2003-01-01

    Fatigue-induced microdamage in bone contributes to stress and fragility fractures and acts as a stimulus for bone remodelling. Detecting such microdamage is difficult as pre-existing microdamage sustained in vivo must be differentiated from artefactual damage incurred during specimen preparation. This was addressed by bulk staining specimens in alcohol-soluble basic fuchsin dye, but cutting and grinding them in an aqueous medium. Nonetheless, some artefactual cracks are partially stained and ...

  2. Fracture Nasal Bone

    Balasubramanian, Thiagarajan; Venkatesan, Ulaganathan

    2013-01-01

    Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography and u...

  3. FRACTURE NASAL BONES

    Balasubramanian Thaigarajan; Venkatesan Ulaganathan

    2013-01-01

    Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography a...

  4. Small Animal Bone Biomechanics

    Vashishth, Deepak

    2008-01-01

    Animal models, in particular mice, offer the possibility of naturally achieving or genetically engineering a skeletal phenotype associated with disease and conducting destructive fracture tests on bone to determine the resulting change in bone’s mechanical properties. Several recent developments, including nano- and micro- indentation testing, microtensile and microcompressive testing, and bending tests on notched whole bone specimens, offer the possibility to mechanically probe small animal ...

  5. Multiscale imaging of bone microdamage

    Poundarik, Atharva A.; Vashishth, Deepak

    2015-01-01

    Bone is a structural and hierarchical composite that exhibits remarkable ability to sustain complex mechanical loading and resist fracture. Bone quality encompasses various attributes of bone matrix from the quality of its material components (type-I collagen, mineral and non-collagenous matrix proteins) and cancellous microarchitecture, to the nature and extent of bone microdamage. Microdamage, produced during loading, manifests in multiple forms across the scales of hierarchy in bone and fu...

  6. Bone Metabolism in Anorexia Nervosa

    Fazeli, Pouneh K.; Klibanski, Anne

    2014-01-01

    Anorexia nervosa (AN), a psychiatric disorder predominantly affecting young women, is characterized by self-imposed chronic nutritional deprivation and distorted body image. AN is associated with a number of medical co-morbidities including low bone mass. The low bone mass in AN is due to an uncoupling of bone formation and bone resorption, which is the result of hormonal adaptations aimed at decreasing energy expenditure during periods of low energy intake. Importantly, the low bone mass in ...

  7. Bone nutrients for vegetarians.

    Mangels, Ann Reed

    2014-07-01

    The process of bone mineralization and resorption is complex and is affected by numerous factors, including dietary constituents. Although some dietary factors involved in bone health, such as calcium and vitamin D, are typically associated with dairy products, plant-based sources of these nutrients also supply other key nutrients involved in bone maintenance. Some research suggests that vegetarian diets, especially vegan diets, are associated with lower bone mineral density (BMD), but this does not appear to be clinically significant. Vegan diets are not associated with an increased fracture risk if calcium intake is adequate. Dietary factors in plant-based diets that support the development and maintenance of bone mass include calcium, vitamin D, protein, potassium, and soy isoflavones. Other factors present in plant-based diets such as oxalic acid and phytic acid can potentially interfere with absorption and retention of calcium and thereby have a negative effect on BMD. Impaired vitamin B-12 status also negatively affects BMD. The role of protein in calcium balance is multifaceted. Overall, calcium and protein intakes in accord with Dietary Reference Intakes are recommended for vegetarians, including vegans. Fortified foods are often helpful in meeting recommendations for calcium and vitamin D. Plant-based diets can provide adequate amounts of key nutrients for bone health. PMID:24898231

  8. Recombinant human bone morphogenetic protein induces bone formation

    The authors have purified and characterized active recombinant human bone morphogenetic protein (BMP) 2A. Implantation of the recombinant protein in rats showed that a single BMP can induce bone formation in vivo. A dose-response and time-course study using the rat ectopic bone formation assay revealed that implantation of 0.5-115 μg of partially purified recombinant human BMP-2A resulted in cartilage by day 7 and bone formation by day 14. The time at which bone formation occurred was dependent on the amount of BMP-2A implanted; at high doses bone formation could be observed at 5 days. The cartilage- and bone-inductive activity of the recombinant BMP-2A is histologically indistinguishable from that of bone extracts. Thus, recombinant BMP-2A has therapeutic potential to promote de novo bone formation in humans

  9. Crosstalk between cancer cells and bone microenvironment in bone metastasis

    Bone, as well as lung and liver, is one of the most preferential metastatic target sites for cancers including breast, prostate, and lung cancers. Although the precise molecular mechanisms underlying this preference need to be elucidated, it appears that bone microenvironments possess unique biological features that enable circulating cancer cells to home, survive and proliferate, and destroy bone. In conjunction, cancers that develop bone metastases likely have the capacity to utilize these unique bone environments for colonization and bone destruction. This crosstalk between metastatic cancer cells and bone is critical to the development and progression of bone metastases. Disruption of this interaction will allow us to design mechanism-based effective and specific therapeutic interventions for bone metastases

  10. [Morphological analysis of bone dynamics and metabolic bone disease. Histomorphometric concepts of bone remodeling and modeling].

    Takahashi, Hideaki E

    2011-04-01

    In tissue level turnover of bone cells, bone remodeling shows a sequential events of activation, resorption, reversal and formation. This may be observed as secondary osteons in the cortical bone and trabecular packets in the cancellous bone. Microcracks are repaired by targeted remodeling, and calcium is released by non-targeted remodeling. In macromodeling, a macroscopic size of a bone increases with growth, without changing its basic figure. In micromodelimg, a shift of trabecula, a minishift, is biomechnically controlled. New lamellar bone is added parallel to compressive and tensile force, and bone resorption occurs at the opposite surface of formation. In minimodeling new lamellar bone is formed with a sequence of activation, then directly formation, without scalloping at the cement line between newly formed bone and its basic bone. PMID:21447918

  11. Porous surface modified bioactive bone cement for enhanced bone bonding.

    Qiang He

    Full Text Available BACKGROUND: Polymethylmethacrylate bone cement cannot provide an adhesive chemical bonding to form a stable cement-bone interface. Bioactive bone cements show bone bonding ability, but their clinical application is limited because bone resorption is observed after implantation. Porous polymethylmethacrylate can be achieved with the addition of carboxymethylcellulose, alginate and gelatin microparticles to promote bone ingrowth, but the mechanical properties are too low to be used in orthopedic applications. Bone ingrowth into cement could decrease the possibility of bone resorption and promote the formation of a stable interface. However, scarce literature is reported on bioactive bone cements that allow bone ingrowth. In this paper, we reported a porous surface modified bioactive bone cement with desired mechanical properties, which could allow for bone ingrowth. MATERIALS AND METHODS: The porous surface modified bioactive bone cement was evaluated to determine its handling characteristics, mechanical properties and behavior in a simulated body fluid. The in vitro cellular responses of the samples were also investigated in terms of cell attachment, proliferation, and osteoblastic differentiation. Furthermore, bone ingrowth was examined in a rabbit femoral condyle defect model by using micro-CT imaging and histological analysis. The strength of the implant-bone interface was also investigated by push-out tests. RESULTS: The modified bone cement with a low content of bioactive fillers resulted in proper handling characteristics and adequate mechanical properties, but slightly affected its bioactivity. Moreover, the degree of attachment, proliferation and osteogenic differentiation of preosteoblast cells was also increased. The results of the push-out test revealed that higher interfacial bonding strength was achieved with the modified bone cement because of the formation of the apatite layer and the osseointegration after implantation in the bony

  12. Mimicking the nanostructure of bone matrix to regenerate bone.

    Kane, Robert; Ma1, Peter X

    2013-11-01

    Key features of bone tissue structure and composition are capable of directing cellular behavior towards the generation of new bone tissue. Bone tissue, as well as materials derived from bone, have a long and successful history of use as bone grafting materials. Recent developments in design and processing of synthetic scaffolding systems has allowed the replication of the bone's desirable biological activity in easy to fabricate polymeric materials with nano-scale features exposed on the surface. The biological response to these new tissue-engineering scaffold materials oftentimes exceeds that seen on scaffolds produced using biological materials. PMID:24688283

  13. Virtual Temporal Bone Anatomy

    2007-01-01

    Background The Visible Human Project(VHP) initiated by the U.S. National Library of Medicine has drawn much attention and interests from around the world. The Visible Chinese Human (VCH) project has started in China. The current study aims at acquiring a feasible virtual methodology for reconstructing the temporal bone of the Chinese population, which may provide an accurate 3-D model of important temporal bone structures that can be used in teaching and patient care for medical scientists and clinicians. Methods A series of sectional images of the temporal bone were generated from section slices of a female cadaver head. On each sectional image, SOIs (structures of interest) were segmented by carefully defining their contours and filling their areas with certain gray scale values. The processed volume data were then inducted into the 3D Slicer software(developed by the Surgical Planning Lab at Brigham and Women's Hospital and the MIT AI Lab) for resegmentation and generation of a set of tagged images of the SOIs. 3D surface models of SOIs were then reconstructed from these images. Results The temporal bone and structures in the temporal bone, including the tympanic cavity, mastoid cells, sigmoid sinus and internal carotid artery, were successfully reconstructed. The orientation of and spatial relationship among these structures were easily visualized in the reconstructed surface models. Conclusion The 3D Slicer software can be used for 3-dimensional visualization of anatomic structures in the temporal bone, which will greatly facilitate the advance of knowledge and techniques critical for studying and treating disorders involving the temporal bone.

  14. Bone scan in pediatrics

    In 1984, a survey carried out in 21 countries in Europe showed that bone scintigraphy comprised 16% of all paediatric radioisotope scans. Although the value of bone scans in paediatrics is potentially great, their quality varies greatly, and poor-quality images are giving this valuable technique a bad reputation. The handling of children requires a sensitive staff and the provision of a few simple inexpensive items of distraction. Attempting simply to scan a child between two adult patients in a busy general department is a recipe for an unhappy, uncooperative child with the probable result of poor images. The intravenous injection of isotope should be given adjacent to the gamma camera room, unless dynamic scans are required, so that the child does not associate the camera with the injection. This injection is best carried out by someone competent in paediatric venipunture; the entire procedure should be explained to the child and parent, who should remain with child throughout. It is naive to think that silence makes for a cooperative child. The sensitivity of bone-seeking radioisotope tracers and the marked improvement in gamma camera resolution has allowed the bone scanning to become an integrated technique in the assessment of children suspected of suffering from pathological bone conditions. The tracer most commonly used for routine bone scanning is 99mTc diphosphonate (MDP); other isotopes used include 99mTc colloid for bone marrow scans and 67Ga citrate and 111In white blood cells (111In WBC) for investigation of inflammatory/infective lesions

  15. Apports de la gestion industrielle au management des périmètres irrigués : comment mieux piloter la production ?

    Rey, Jacques

    1996-01-01

    Deux idées directrices sont à l'origine de cette thèse : (1) la gestion de l'eau dans les périmètres irrigués pose problème et nombre d'interventions conduites pour l'améliorer pèchent par manque de réalisme : pas assez opérationnelles pour être vraiment pertinentes, pas assez globales pour être durablement efficaces, (2) le recours à une analogie entre les périmètres irrigués et les entreprises industrielles peut être éclairant pour mettre à jour certaines spécificités des périmètres en tant...

  16. Effects of Carburized Parts on Residual Stresses of Thin-Rimmed Spur Gears with Symmetric Web Arrangements Due to Case-Carburizing

    Kouitsu Miyachika; Wei-Dong Xue; Satoshi Oda; Hidefumi Mada; Hiroshige Fujio

    2004-01-01

    This paper presents a study on effects of carburized parts on residual stresses of thin-rimmed spur gears with symmetric web arrangements due to the case-carburizing. The carbon content of each element of the FEM gear model due to carburizing was obtained according to Vickers hardness Hv - carbon content C% and C% - d (distance from surface)charts. A heat conduction analysis and an elastic-plastic stress analysis during the case-carburizing process of thin-rimmed spur gears with symmetric web arrangements were carried out for various case-carburizing conditions by using the three-dimensional finite element method (3D-FEM) program developed by authors, and then residual stresses were obtained.The effects of the carburized part, the web structure, and the rim thickness on the residual stress were determined.

  17. Bone scintigraphy of decompression sickness

    Value of bone scintigraphy in decompression sickness of 42 patients was retrospectively evaluated. Bone scintigraphy was positive in 30 of 42 patients (83 lesions), while radiography and symptoms were positive in 23 patients (48 lesions), and in 29 patients (44 lesions) respectively. Bone scintigraphy was positive in many lesions with negative radiography or symptoms. However, approximately half of the lesions in which either radiography or symptoms was positive could not be detected by bone scintigraphy. These cases mostly showed radiographic abnormalities such as irregular calcified areas and ''bone island'' in the cervical regions of the humerus, femur and tibia. Both bone scintigraphy and radiography were positive in most of the patients with symptoms of the bends and there seems to be a close relationship between the bends symptoms and bone lesion. We concluded that bone scintigraphy is useful for the evaluation of decompression sickness, but it must be complemented by bone radiography to avoid a significant number of false negative cases. (author)

  18. Bone health in eating disorders.

    Zuckerman-Levin, N; Hochberg, Z; Latzer, Y

    2014-03-01

    Eating disorders (EDs) put adolescents and young adults at risk for impaired bone health. Low bone mineral density (BMD) with ED is caused by failure to accrue peak bone mass in adolescence and bone loss in young adulthood. Although ED patients diagnosed with bone loss may be asymptomatic, some suffer bone pains and have increased incidence of fractures. Adolescents with ED are prone to increased prevalence of stress fractures, kyphoscoliosis and height loss. The clinical picture of the various EDs involves endocrinopathies that contribute to impaired bone health. Anorexia nervosa (AN) is characterized by low bone turnover, with relatively higher osteoclastic (bone resorptive) than osteoblastic (bone formation) activity. Bone loss in AN occurs in both the trabecular and cortical bones, although the former is more vulnerable. Bone loss in AN has been shown to be influenced by malnutrition and low weight, reduced fat mass, oestrogen and androgen deficiency, glucocorticoid excess, impaired growth hormone-insulin-like growth factor 1 axis, and more. Bone loss in AN may not be completely reversible despite recovery from the illness. Treatment modalities involving hormonal therapies have limited effectiveness, whereas increased caloric intake, weight gain and resumption of menses are essential to improved BMD. PMID:24165231

  19. Nd and Sr isotope compositions in modern and fossil bones - Proxies for vertebrate provenance and taphonomy

    Tütken, Thomas; Vennemann, Torsten W.; Pfretzschner, Hans-U.

    2011-10-01

    Rare earth elements (REE), while not essential for the physiologic functions of animals, are ingested and incorporated in ppb concentrations in bones and teeth. Nd isotope compositions of modern bones of animals from isotopically distinct habitats demonstrate that the 143Nd/ 144Nd of the apatite can be used as a fingerprint for bedrock geology or ambient water mass. This potentially allows the provenance and migration of extant vertebrates to be traced, similar to the use of Sr isotopes. Although REE may be enriched by up to 5 orders of magnitude during diagenesis and recrystallization of bone apatite, in vivo143Nd/ 144Nd may be preserved in the inner cortex of fossil bones or enamel. However, tracking the provenance of ancient or extinct vertebrates is possible only for well-preserved archeological and paleontological skeletal remains with in vivo-like Nd contents at the ppb-level. Intra-bone and -tooth REE analysis can be used to screen for appropriate areas. Large intra-bone Nd concentration gradients of 10 1-10 3 are often measured. Nd concentrations in the inner bone cortex increase over timescales of millions of years, while bone rims may be enriched over millenial timescales. Nevertheless, ɛ Nd values are often similar within one ɛ Nd unit within a single bone. Larger intra-bone differences in specimens may either reflect a partial preservation of in vivo values or changing ɛ Nd values of the diagenetic fluid during fossilization. However, most fossil specimens and the outer rims of bones will record taphonomic 143Nd/ 144Nd incorporated post mortem during diagenesis. Unlike REE patterns, 143Nd/ 144Nd are not biased by fractionation processes during REE-uptake into the apatite crystal lattice, hence the ɛ Nd value is an important tracer for taphonomy and reworking. Bones and teeth from autochthonous fossil assemblages have small variations of ±1 ɛ Nd unit only. In contrast, fossil bones and teeth from over 20 different marine and terrestrial fossil

  20. Inca bones at asterion

    Prashant E Natekar

    2014-01-01

    Full Text Available Background: Surgical approach towards asterion has to be done with caution as many surgeons are unfamiliar with the anatomical variations. The asterion corresponds to the site of the posterolateral (mastoid fontanelle of the neonatal skull which closes at the end of the first year. Inca bones provide information as markers for various diseases, and can mislead in the diagnosis of fractures. Observation and Results: 150 dry skull bones from the Department of Anatomy at Goa Medical College, India and other neighboring medical colleges by examining the asterion, and its sutural articulations with parietal, temporal and occipital bones and also anatomical variations if any in adults. Discussion: The anatomical landmarks selected must be reliable and above all easy to identify. Bony structures are more suitable than soft tissue or cartilaginous landmarks because of their rigid and reliable location. Presence of these bones provides false impressions of fractures or the fractures may be interpreted for inca bones especially in the region of asterion either radiologically or clinically which may lead to complications during burr hole surgeries.

  1. Periostin action in bone.

    Bonnet, Nicolas; Garnero, Patrick; Ferrari, Serge

    2016-09-01

    Periostin is a highly conserved matricellular protein that shares close homology with the insect cell adhesion molecule fasciclin 1. Periostin is expressed in a broad range of tissues including the skeleton, where it serves both as a structural molecule of the bone matrix and a signaling molecule through integrin receptors and Wnt-beta-catenin pathways whereby it stimulates osteoblast functions and bone formation. The development of periostin null mice has allowed to elucidate the crucial role of periostin on dentinogenesis and osteogenesis, as well as on the skeletal response to mechanical loading and parathyroid hormone. The use of circulating periostin as a potential clinical biomarker has been explored in different non skeletal conditions. These include cancers and more specifically in the metastasis process, respiratory diseases such as asthma, kidney failure, renal injury and cardiac infarction. In postmenopausal osteoporosis, serum levels have been shown to predict the risk of fracture-more specifically non-vertebral- independently of bone mineral density. Because of its preferential localization in cortical bone and periosteal tissue, it can be speculated that serum periostin may be a marker of cortical bone metabolism, although additional studies are clearly needed. PMID:26721738

  2. Fibrosarcoma of bone

    A general clinical-radiological description of fibrosarcoma of bone, including tumours with features of malignant fibrous histiocytoma is presented. 104 patients with fibrosarcoma of the long bones are analysed in terms of age and sex distribution, symptoms, duration of symptoms and tumour localization. The radiological findings obtained in patients with fibrosarcoma of the long bones are discussed. The treatment and course of fibrosarcoma of the long bones are discussed. Data on the type of therapy given were available on 103 patients: 67 were treated by ablative surgery either immediately or within three months of preceding local surgery and/or radiotherapy. In the remaining 36 cases treatment consisted of local surgery, radiotherapy or a combination of these, or non-curative (palliative) treatment. In a few cases ablative surgery was performed at a later stage. 13 patients with fibrosarcoma of the axial skeleton and 14 with fibrosarcoma of the jaws are considered. A causistic discussion of patients with a secondary fibrosarcoma is presented. Secondary fibrosarcoma was found in a total of 19 patients (14%); 4 after irradiation. The features of significance for the course of the disease are discussed: general features such as age and sex, tumour localization in the long bones, presence or absence of a pathological fracture, and the radiological and histological characteristics of the tumour. The type of therapy and the occurrence of lung metastases in relation to the course of the disease is also discussed. (Auth.)

  3. Bone metabolism during pregnancy.

    Salles, Jean Pierre

    2016-06-01

    During pregnancy, mineral concentrations, of calcium and phosphorus in particular, are maintained at a high level in fetal blood so that the developing skeleton may accrete adequate mineral content. The placenta actively transports minerals for this purpose. Maternal intestinal absorption increases in order to meet the fetal demand for calcium, which is only partly dependent on calcitriol. Mineral regulation is essentially dependent on parathyroid hormone (PTH) and PTH-related protein (PTHrP). The calcium-sensing receptor (CaSR) regulates PTH and PTHrP production. If calcium intake is insufficient, the maternal skeleton will undergo resorption due to PTHrP. After birth, a switch from fetal to neonatal homeostasis occurs through increase in PTH and calcitriol, and developmental adaptation of the kidneys and intestines with bone turnover contributing additional mineral to the circulation. Calcium absorption becomes progressively active and dependent on calcitriol. The postnatal skeleton can transiently present with osteoposis but adequate mineral diet usually allows full restoration. Cases of primary osteoporosis must be identified. Loss of trabecular mineral content occurs during lactation in order to provide calcium to the newborn. This programmed bone loss is dependent on a "brain-breast-bone" circuit. The physiological bone resorption during reproduction does not normally cause fractures or persistent osteoporosis. Women who experience fracture are likely to have other causes of bone loss. PMID:27157104

  4. Cholesteatoma of the temporal bone. MR findings

    Park, Yoon Ok; Youn, Eun Kyung; Chung, Eun Chul; Lee, Young Uk; Kim, Dong Ju; Chin, Seung Byum; Keum, Joo Seob [Sungkyunkwan Univ. Colledge of Medicine. Kangbuk Samsung Hospital, Seoul (Korea, Republic of)

    1998-07-01

    The purpose of this study is to evaluate the diagnostic capability of MR imaging for distinguishing cholesteatoma from other causes of inflammation. Materials and Methods : We prospectively evaluated the MR images of 17 patients with a fully opacified middle ear in whom CT of the temporal bone suggested cholesteatoma. All patients underwent middle ear surgery and cholesteatoma was verified in 15 cases, granulation tissue in 15,cholesterol granuloma in four and hemotympanium in one. For each lesion, MR and pathologic findings were correlated. Results : All cases of cholesteatoma showed low to intermediate signal intensity on T1-weighted images. On T2-weighted images, 11 cases showed high signal intensity, while seven were less than CSF and four were the same. Four cases revealed central low signal intensity with peripheral rim of high signal intensity. On GdDTPA-enhanced images, peripheral or marginal enhancement due to surrounding granulation tissue was noted in 12 cases. Two appeared to be totally enhanced. One case of congenital cholesteatoma showed no enhancement. OnT2-weighted images, all cases of granulation tissue showed high signal intensity, and on neither T1- nor T2-weighted images could these be distinguished from cholesteatoma. On Gd DTPA-enhanced study, all cases of granulation tissue were enhanced, and on T1WI, all cases of cholesterol granuloma showed homogeneous bright signal intensity on T1WI. One case of cholesterol granuloma in the mastoid showed bright signal intensity mixed with irregular areas of dark signal intensity. A further comparison of MR imaging with CT is that two case of labyrinthitis and one of meningitis were diagnosed on Gd- enhanced T1-weighted images. Conclusion : To differentiate cholesteatoma from granulation tissue and cholesterol granuloma by the evaluation of their signal intensities and enhancement patterns, MR imaging is superior to CT. When there are cholesteatoma-associated complications such as labyrinthitis or

  5. VNIR Multispectral Observations of Rocks at Spirit of St. Louis Crater and Marathon Valley on Th Rim of Endeavour Crater Made by the Opportunity Rover Pancam

    Farrand, W. H.; Johnson, J. R.; Bell, J. F., III; Mittlefehldt, D.W.

    2016-01-01

    The Mars Exploration Rover Opportunity has been exploring the western rim of the 22 km diameter Endeavour crater since August, 2011. Recently, Opportunity has reached a break in the Endeavour rim that the rover team has named Mara-thon Valley. This is the site where orbital observations from the MRO CRISM imaging spectrometer indicated the presence of iron smectites. On the outer western portion of Marathon Valley, Opportunity explored the crater-form feature dubbed Spirit of St. Louis (SoSL) crater. This presentation describes the 430 to 1009 nm (VNIR) reflectance, measured by the rover's Pancam, of rock units present both at Spirit of St. Louis and within Marathon Valley.

  6. [Inflammation and bone : Osteoimmunological aspects].

    Frommer, K W; Neumann, E; Lange, U

    2016-06-01

    Microscopic fractures (so-called microcracks) or traumatic macrofractures require bone, as the basic scaffold of the human body, to have a high regenerative capability. In order to be able to provide this regenerative capability, bone is in a constant process of remodeling. This finely tuned homeostasis of bone formation and degradation can become disrupted, which leads to osteoporosis or other bone disorders. It has been shown that the immune system is substantially involved in the regulation of bone homeostasis and that chronic inflammation in particular can disturb this balance; therefore, this article reviews the osteoimmunological aspects contributing to osteoporosis and other diseases associated with bone degradation. PMID:27250491

  7. Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers

    Zeeshan Sheikh

    2015-04-01

    Full Text Available Trauma and disease frequently result in fractures or critical sized bone defects and their management at times necessitates bone grafting. The process of bone healing or regeneration involves intricate network of molecules including bone morphogenetic proteins (BMPs. BMPs belong to a larger superfamily of proteins and are very promising and intensively studied for in the enhancement of bone healing. More than 20 types of BMPs have been identified but only a subset of BMPs can induce de novo bone formation. Many research groups have shown that BMPs can induce differentiation of mesenchymal stem cells and stem cells into osteogenic cells which are capable of producing bone. This review introduces BMPs and discusses current advances in preclinical and clinical application of utilizing various biomaterial carriers for local delivery of BMPs to enhance bone regeneration.

  8. A STUDY ON PREVALENCE OF DEPRESSION IN ATTEMPTED SUICIDE PATIENTS ATTENDING R.I.M.S . HOSPITAL, IMPHAL

    Hemchand Singh

    2014-02-01

    Full Text Available OBJECTIVE: To evaluate prevalence of depression in individuals who attempted suicide and attended Regional Institute of Medical Sciences Hospital , Imphal. Method: The study was cross - sectional in which 50 patients who attempted suicide and attend ed RIMS Hospital and fulfilled the inclusion criteria were included in the study which was conducted from November 2005 to October 2006. A semi - structured interview schedule was used to find out the socio - demographic profile. Present State Examination was used for symptom elicitation and ICCD - 10 was used for confirming the diagnosis. RESULTS : Males (64% outnumbered females. Sixty - four present had psychiatric illness , depressive episode (28% being the most common diagnosis. CONCLUSION : Depressives episode was found to be commonest psychiatric illness in patients who attempted suicide.

  9. PIG (partially ionized globule) anatomy - Density and temperature structure of the bright-rimmed globule IC 1396E

    Serabyn, E.; Guesten, R.; Mundy, L.

    1993-01-01

    The density and temperature structure of the bright-rimmed cometary globule IC 1396E is estimated, and the possibility that recent internal star formation was triggered by the ionization front in its southern surface is assessed. On the basis of NH3 data, gas temperatures in the globule are found to increase outward from the center, from a minimum of 17 K in its tail to a maximum of 26 K on the surface most directly facing the stars ionizing IC 1396. On the basis of a microturbulent radiative transfer code to model the radial dependence of the CS line intensities, and also the intensities of the optically thin 2-1 and 5-4 lines toward the cloud center, a radial density dependence of r exp -1.55 to r exp -1.75 is found.

  10. Greenhouse gas emissions trading among Pacific Rim countries: An analysis of policies to bring developing countries to the bargaining table

    This paper examines the aggregate net costs and individual country cost savings of greenhouse gas emissions trading among Pacific Rim countries. We propose emission permit allocation rules designed to entice developing countries to participate. Absence of developing country involvement has served as an excuse for the lack by participation by the United States in the first compliance period of the Kyoto Protocol and may serve as a disincentive to even more countries in subsequent periods. Our analysis specifies permit allocation rules that could result in no net costs, and even cost-savings, to developing countries for their involvement in the emissions trading market, while at the same time providing extensive benefits to industrialized countries through access to lower-cost mitigation alternatives

  11. Radiotherapy for bone metastases

    Between December 1986 and January 1978, 68 patients with bone metastases were analyzed to evaluate the effect of radiation for the relief of pain. The 68 patients, who had a total of 97 lesions, complained of pain caused by their bone metastasis. The good, fair, and poor responses were found to be 18%, 60%, and 22%, respectively. With reference to the primary neoplasms, the effective response rate was 73% in lung cancer, 100% in breast cancer, 75% in gastric cancer, 100% in hepatic cancer, 100% in bladder cancer, 25% in epipharyngeal cancer, and 70% in the other neoplasms. Depending on the cell types of the lung cancer, the effective response rate was 80% for small cell carcinomas, 72% for adenocarcinomas and 40% for squamous cell carcinomas. Our results suggest that radiotherapy for bone metastases is to be recommended, since the effective response rate was 78% for the relief of pain. (author)

  12. Biochemical markers of bone turnover

    Biochemical markers of bone turnover has received increasing attention over the past few years, because of the need for sensitivity and specific tool in the clinical investigation of osteoporosis. Bone markers should be unique to bone, reflect changes of bone less, and should be correlated with radiocalcium kinetics, histomorphometry, or changes in bone mass. The markers also should be useful in monitoring treatment efficacy. Although no bone marker has been established to meet all these criteria, currently osteocalcin and pyridinium crosslinks are the most efficient markers to assess the level of bone turnover in the menopausal and senile osteoporosis. Recently, N-terminal telopeptide (NTX), C-terminal telopeptide (CTX) and bone specific alkaline phosphatase are considered as new valid markers of bone turnover. Recent data suggest that CTX and free deoxypyridinoline could predict the subsequent risk of hip fracture of elderly women. Treatment of postmenopausal women with estrogen, calcitonin and bisphosphonates demonstrated rapid decrease of the levels of bone markers that correlated with the long-term increase of bone mass. Factors such as circadian rhythms, diet, age, sex, bone mass and renal function affect the results of biochemical markers and should be appropriately adjusted whenever possible. Each biochemical markers of bone turnover may have its own specific advantages and limitations. Recent advances in research will provide more sensitive and specific assays

  13. Multiscale imaging of bone microdamage.

    Poundarik, Atharva A; Vashishth, Deepak

    2015-04-01

    Bone is a structural and hierarchical composite that exhibits remarkable ability to sustain complex mechanical loading and resist fracture. Bone quality encompasses various attributes of bone matrix from the quality of its material components (type-I collagen, mineral and non-collagenous matrix proteins) and cancellous microarchitecture, to the nature and extent of bone microdamage. Microdamage, produced during loading, manifests in multiple forms across the scales of hierarchy in bone and functions to dissipate energy and avert fracture. Microdamage formation is a key determinant of bone quality, and through a range of biological and physical mechanisms, accumulates with age and disease. Accumulated microdamage in bone decreases bone strength and increases bone's propensity to fracture. Thus, a thorough assessment of microdamage, across the hierarchical levels of bone, is crucial to better understand bone quality and bone fracture. This review article details multiple imaging modalities that have been used to study and characterize microdamage; from bulk staining techniques originally developed by Harold Frost to assess linear microcracks, to atomic force microscopy, a modality that revealed mechanistic insights into the formation diffuse damage at the ultrastructural level in bone. New automated techniques using imaging modalities, such as microcomputed tomography are also presented for a comprehensive overview. PMID:25664772

  14. Bone Targeted Therapies for Bone Metastasis in Breast Cancer

    Wajeeha Razaq

    2013-01-01

    Cancer metastasis to the bone develops commonly in patients with various malignancies, and is a major cause of morbidity and diminished quality of life in many affected patients. Emerging treatments for metastatic bone disease have arisen from advances in our understanding of the unique cellular and molecular mechanisms that contribute to the bone metastasis. The tendency of cancer cells to metastasize to bone is probably the end result of many factors including vascular pathways, the highly ...

  15. Bone formation following implantation of bone biomaterials into extraction sites

    Molly, Liene; Vandromme, Heleen; Quirynen, Marc; Schepers, Evert; Adams, Jessica L; van Steenberghe, Daniel

    2008-01-01

    Background: Adequate bone volume is imperative for the osseointegration of endosseous implants, but post-extraction resorption and remodeling may challenge implant placement. The use of bone biomaterials has been advocated to fill extraction sites and to enhance primary implant stability during osseointegration. The objective of the case series was to evaluate bone formation histologically and biomechanically in extraction sites following implantation of three commercially available bone biom...

  16. 浙江省淳安县发生桑叶菌核病的病原与发病规律调查%An Investigation to Pathogen and Occurrence Regularity of Mulberry Leaf Sclerote Disease Occurring in Chun'an County of Zhejiang Province

    肖建京; 蒯元璋; 张帆; 丰卫忠

    2012-01-01

    An peculiar and severe mulberry leaf spot disease happened in mulberry field of Chun'an Country, Zhejiang Province in autumn of 2011. The diseased leaves presented typical symptoms of sclerote disease; grayish brown, ring pattern and water-soaked disease spots formed on surface of leaves; disease spots extended outward concentrically with onset of disease; color of the disease spots deepened from inside to outside; and many concentric circle-shaped and villous mycelia and conidiospores appeared at grey and round-shaped disease spots on leaf back. Optical microscopic observation confirmed morphology of mycelia and conidiospores in tissues from disease spots, tissues surrounding the disease spots, and villous tissues from concentric circles of the disease spots. Sclerotia formed by mycelium could be observed from pathogens isolated and cultured on PDA medium by using peripheric tissues of the disease spots. Based on the above symptoms and morphological features of isolated and cultured pathogenic fungus, this disease was identi fied as mulberry leaf sclerote disease. Its pathogenic fungus was Sclerotinia fuckeliana (de Bary) Fuck.. A survey conducted to 480 mulberry trees at 16 test sites showed that disease incidence on plants was 81. 25%, disease incidence on leaves was 37. 63%, and disease index was 18. 5. In September and October of 2011, the local temperature was 24. 4 ~18. 7 ℃ and rainy weather continued for a long time. In addition, the local collective mulberry fields had poor ventilation and illumination condition, creating an environment of high relative humidity. Therefore, the pathogenic fungi reproduced rapidly and the disease became epidemic. No mulberry variety has been found to have obvious resistance against it.%2011年秋季,浙江省淳安县的桑园大面积发生一种罕见的桑叶特大病斑病害.病叶呈现菌核病的典型症状:叶面形成灰褐色轮纹水渍状病斑,病斑随着病情发展以同心圆状向外

  17. Bone pathology inpsoriatic arthritis

    V. V. Badokin

    2007-10-01

    Full Text Available Objective. To study different variants of osteolysis in pts with psoriatic arthritis (PA and to reveal their relationship with other clinico-radiological features of joint damage. Material and methods. 370 pts with definite PA having different variants of joint damage were included. Radiological examination of bones and joints (in some cases large picture frame was performed. Morphological evaluation of synovial biopsies was done in 34 pts with PA and 10 pts with rheumatoid arthritis (RA. Results. Different types of osteolysis were revealed in 80 (21,6% pts. Osteolytic variant of joint damage was present in 29 pts. 33 pts had acral, 48 — intra-articular osteolysis and 16 - true bone atrophy. Frequency and intensity of bone resorption were associated with severity of PA. Acral osteolysis correlated with arthritis of distal interphalangeal joints and onychodystrophy. Intra-articular osteolysis was most often present in distal interphalangeal joints of hands and metacarpophalangeal joints (39,6% and 41,7% respectively. Characteristic feature of PA was combination of prominent resorption with formation of bone ankylosis and periosteal reaction. Ankylosis was present in 33,3% of pts with intra-articular osteolysis and in 60% of pts with combination of different osteolysis variants. Systemic reaction of microcirculation in synovial biopsies was most prominent in osteolytic variant: marked thickening of capillary and venule basal membrane with high level of acid phosphatase, increased capillary and precapillary blood flow with stasis features, vascular lymphocyte and macrophage infiltration, productive vasculitis with annular wall thickening, thrombovasculitis and villi deep layer sclerosis. Conclusion. Different variants of osteolysis show bone involvement in PA. Acral and intra- articular osteolysis association with bone ankylosis and periostitis proves their common pathogenetic entity.

  18. Archival bone marrow samples

    Lund, Bendik; Najmi, Laeya A; Wesolowska-Andersen, Agata;

    2015-01-01

    AB Archival samples represent a significant potential for genetic studies, particularly in severe diseases with risk of lethal outcome, such as in cancer. In this pilot study, we aimed to evaluate the usability of archival bone marrow smears and biopsies for DNA extraction and purification, whole...... with samples stored for 4 to 10 years. Acceptable call rates for SNPs were detected for 7 of 42 archival samples. In conclusion, archival bone marrow samples are suitable for DNA extraction and multiple marker analysis, but WGA was less successful, especially when longer fragments were analyzed. Multiple SNP...

  19. FRACTURE NASAL BONES

    Balasubramanian Thaigarajan

    2013-03-01

    Full Text Available Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography and ultrasound in their diagnosis and their management.

  20. [Cytogenetics of bone sarcomas].

    Vagner-Capodano, A M; Poitout, D

    There has been much progress in the cytogenesis, and molecular biology of bone tumours such as Ewing sarcoma and osteosarcomas, greatly improving diagnostic possibilities and prognosis. Ewing's sarcoma is an indifferentiated sarcoma with round cells which usually occurs in children or adolescents. Ewing's sarcoma corresponds to 6% of all bone tumours. Histologically Ewing's sarcoma belongs to a group of small round cell tumours including neuroblastoma, embryon and alveolar rhabdomyosarcoma and non-Hodgkin's lymphoma. Differential diagnosis is difficult. Cytogenetic examinations can now differentiate Ewing's sarcoma from other small round cell tumours. There is a specific 11:12 translocation (q24; q12) which can be used as a marker. PMID:8785922

  1. Computerized geometric features of carpal bone for bone age estimation

    Chi-Wen Hsieh; Tai-Lang Jong; Yi-Hong Chou; Chui-Mei Tiu

    2007-01-01

    Background Bone age development is one of the significant indicators depicting the growth status of children.However, bone age assessment is an heuristic and tedious work for pediatricians. We developed a computerized bone age estimation system based on the analysis of geometric features of carpal bones.Methods The geometric features of carpals were extracted and analyzed to judge the bone age of children by computerized shape and area description. Four classifiers, linear, nearest neighbor, back-propagation neural network,and radial basis function neural network, were adopted to categorize bone age. Principal component and discriminate analyses were employed to improve assorting accuracy.Results The hand X-ray films of 465 boys and 444 girls served as our database. The features were extracted from carpal bone images, including shape, area, and sequence. The proposed normalization area ratio method was effective in bone age classification by simulation. Besides, features statistics showed similar results between the standard of the Greulich and Pyle atlas and our database.Conclusions The bone area has a higher discriminating power to judge bone age. The ossification sequence of trapezium and trapezoid bones between Taiwanese and the atlas of the GP method is quite different. These results also indicate that carpal bone assessment with classification of neural networks can be correct and practical.

  2. Bone lesions in early syphilis detected by bone scintigraphy.

    Hansen, K.; Hvid-Jacobsen, K; Lindewald, H; Sørensen, P S; Weismann, K

    1984-01-01

    We report a case of early syphilis with multiple bone lesions which all resolved after treatment with penicillin. We discuss why bone lesions may be more prevalent than generally believed and why 99m-Tc-MDP-bone scintigraphy is more sensitive than radiography in detecting syphilitic periostitis.

  3. Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation.

    Amend, Sarah R; Valkenburg, Kenneth C; Pienta, Kenneth J

    2016-01-01

    Investigation of the bone and the bone marrow is critical in many research fields including basic bone biology, immunology, hematology, cancer metastasis, biomechanics, and stem cell biology. Despite the importance of the bone in healthy and pathologic states, however, it is a largely under-researched organ due to lack of specialized knowledge of bone dissection and bone marrow isolation. Mice are a common model organism to study effects on bone and bone marrow, necessitating a standardized and efficient method for long bone dissection and bone marrow isolation for processing of large experimental cohorts. We describe a straightforward dissection procedure for the removal of the femur and tibia that is suitable for downstream applications, including but not limited to histomorphologic analysis and strength testing. In addition, we outline a rapid procedure for isolation of bone marrow from the long bones via centrifugation with limited handling time, ideal for cell sorting, primary cell culture, or DNA, RNA, and protein extraction. The protocol is streamlined for rapid processing of samples to limit experimental error, and is standardized to minimize user-to-user variability. PMID:27168390

  4. A degradable soybean-based biomaterial used effectively as a bone filler in vivo in a rabbit

    Merolli, Antonio [Department of Orthopaedic Surgery, The Catholic University in Rome, Complesso Columbus, via Moscati 31, 00168 Rome (Italy); Nicolais, Luigi; Ambrosio, Luigi [Institute of Composite and Biomedical Materials, Consiglio Nazionale delle Ricerche, Piazzale Tecchio 80, 80130 Napoli (Italy); Santin, Matteo [School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Lewes Road, Brighton BN2 4 GJ (United Kingdom)

    2010-02-15

    The 'gold standard' for bone filling is currently the bone autograft, but its use is limited by material availability and by the possible risks of infection or other donor site morbidity. Materials proposed so far as bone fillers do not show all the characteristics which are desirable. These are (a) osteoconductivity, (b) controlled biodegradation and (c) ease of adaptation to the implantation site. Recently, a new class of biodegradable material based on soybeans has been presented which shows good mechanical properties and an intrinsic bioactivity on inflammatory and tissue cells in vitro. The authors investigated the morphology in vivo of bone response in repairing a surgical lesion in the presence of granules of a novel soybean-based biomaterial (SB), comparing it with a sham-operated contralateral lesion of critical size (non-healing model); 26 operations were performed in New Zealand White rabbits, with back scattered electron microscopy as the analysis technique of choice. Implantation of SB granules over 8 weeks produced bone repair with features distinct from those obtained by healing in a non-treated defect. New and progressively maturing trabeculae appeared in the animal group where SB granules were implanted, while sham operation produced only a rim of pseudo-cortical bone still featuring a large defect. The trabeculae forming in the presence of SB granules had features typical of reticular bone. These findings suggest that the bone regeneration potential of SB granules and their intrinsic bioactivity, combined with their relatively easy and cost-effective preparation procedures, make them suitable candidates as a bone filler in clinical applications.

  5. Vitamin D, Calcium, and Bone Health

    ... Balance › Vitamin D, Calcium, and Bone Health Vitamin D, Calcium, and Bone Health March 2012 Download PDFs ... helps keep your bones strong. Why are vitamin D and calcium important to bone health? Vitamin D ...

  6. Bone X-Ray (Radiography)

    Full Text Available ... around or in bones. top of page How should I prepare? Most bone x-rays require no ... might interfere with the x-ray images. Women should always inform their physician and x-ray technologist ...

  7. Uranium concentrations in human bone

    The natural uranium content in the bone of one person has been determined by a new method. The results were obtained by quantitative analysis of fission track autoradiographs of bone from a person injected witn 239Pu

  8. Limb Salvage After Bone Cancer

    ... Blog Donate Now Select Page Limb Salvage After Bone Cancer Home > Understanding Children’s Cancer > Late Effects of Treatment > Limb Salvage After Bone Cancer Limb salvage is a surgical procedure that replaces ...

  9. Bone Anchored Hearing Treatment Procedure

    Full Text Available ... transmitted very efficiently through the head using bone conduction. The Baha device uses sound vibrations, and those ... changed from a normal soundwave into a bone conduction vibration, and that is what is passed then ...

  10. Anorexia nervosa and bone metabolism.

    Fazeli, Pouneh K; Klibanski, Anne

    2014-09-01

    Anorexia nervosa (AN) is a psychiatric disorder characterized by self-induced starvation with a lifetime prevalence of 2.2% in women. The most common medical co-morbidity in women with AN is bone loss, with over 85% of women having bone mineral density values more than one standard deviation below an age comparable mean. The low bone mass in AN is due to multiple hormonal adaptations to under nutrition, including hypothalamic amenorrhea and growth hormone resistance. Importantly, this low bone mass is also associated with a seven-fold increased risk of fracture. Therefore, strategies to effectively prevent bone loss and increase bone mass are critical. We will review hormonal adaptations that contribute to bone loss in this population as well as promising new therapies that may increase bone mass and reduce fracture risk in AN. PMID:24882734

  11. Vitamin A and Bone Health

    ... supported by your browser. Home Bone Basics Nutrition Vitamin A and Bone Health Publication available in: PDF ( ... Find More Information? For Your Information What Is Vitamin A? Vitamin A is a family of compounds ...

  12. Bone Anchored Hearing Treatment Procedure

    Full Text Available ... The Baha system consists of a bone-anchored titanium fixture that is implanted in the mastoid bone, ... the -- great. I'm going to grab the titanium implant. And what I want you to notice ...

  13. Bone X-Ray (Radiography)

    Full Text Available ... your doctor to view and assess bone fractures, injuries and joint abnormalities. This exam requires little to ... fusion, joint replacement and fracture reductions. look for injury, infection, arthritis , abnormal bone growths and bony changes ...

  14. Bone X-Ray (Radiography)

    Full Text Available ... little information about muscles, tendons or joints. An MRI may be more useful in identifying bone and ... bones and the spinal cord can be evaluated). MRI can also detect subtle or occult fractures or ...

  15. Bone-marrow transplant - slideshow

    ... this page: //medlineplus.gov/ency/presentations/100112.htm Bone-marrow transplant - series To use the sharing features on ... slide 4 out of 4 Normal anatomy Overview Bone-marrow is a soft, fatty tissue found inside of ...

  16. Anorexia nervosa and bone metabolism

    Fazeli, Pouneh K.; Klibanski, Anne

    2014-01-01

    Anorexia nervosa (AN) is a psychiatric disorder characterized by self-induced starvation with a lifetime prevalence of 2.2% in women. The most common medical co-morbidity in women with AN is bone loss, with over 85% of women having bone mineral density values more than one standard deviation below an age comparable mean. The low bone mass in AN is due to multiple hormonal adaptations to under nutrition, including hypothalamic amenorrhea and growth hormone resistance. Importantly, this low bone mass is also associated with a seven-fold increased risk of fracture. Therefore, strategies to effectively prevent bone loss and increase low bone mass are critical. We will review hormonal adaptations that contribute to bone loss in this population as well as promising new therapies that may increase bone mass and reduce fracture risk in AN. PMID:24882734

  17. Cancellous structure of tarsal bones.

    D N Sinha

    1985-01-01

    The internal structure of the tarsal bones has been studied to investigate their cancellous architecture. It is revealed that these bones have fine and coarse meshworks and even a tendency for obliteration of the trabecular pattern in the bones lying distal to this midtarsal joint. Internal structure of the talus does not show an arched pattern of bony lamellae. An increased density of bony lamellae in the internal structure of the navicular bone could result from excessive stress, enforced b...

  18. Bone microdamage and cell apoptosis

    Noble B.

    2003-01-01

    Accumulation of microdamage in bone leads to the reduced strength of our skeleton. In health, bone adapts to the prevailing mechanical needs of the organism and is also capable of self-repair, sensing, removing and replacing damaged or mechanically insufficient volumes of bone. In disease and old age these characteristics are reduced. In order to undertake both of the processes of functional adaptation and repair the bone resorbing and forming cells must be very accurately targeted to areas o...

  19. Cellular and Molecular Mechanisms of Bone Remodeling*

    Raggatt, Liza J; Partridge, Nicola C

    2010-01-01

    Physiological bone remodeling is a highly coordinated process responsible for bone resorption and formation and is necessary to repair damaged bone and to maintain mineral homeostasis. In addition to the traditional bone cells (osteoclasts, osteoblasts, and osteocytes) that are necessary for bone remodeling, several immune cells have also been implicated in bone disease. This minireview discusses physiological bone remodeling, outlining the traditional bone biology dogma in light of emerging ...

  20. Breast Cancer and Bone Loss

    ... Balance › Breast Cancer and Bone Loss Fact Sheet Breast Cancer and Bone Loss July, 2010 Download PDFs English ... JoAnn Pinkerton, MD What is the link between breast cancer and bone loss? Certain treatments for breast cancer ...