WorldWideScience
1

Sclerotic variant of lymphangiomatosis of bone: imaging findings at diagnosis and long-term follow-up  

International Nuclear Information System (INIS)

Lymphangiomatosis is an extremely rare congenital disorder affecting visceral organs and/or the skeletal system. In bone is is usually characterized by multiple lytic lesions with a lacelike pattern and sclerotic margins of various thickness. In this case report we demonstrate the rare sclerotic variant of lymphangiomatosis. We report the development of predominantly sclerotic lesions at different sites by serial radiographs with a long-term follow-up, and show the MRI findings of lymphangiomatosis of the spine. (orig.)

2

Cystic angiomatosis of bone with sclerotic changes mimicking osteoblastic metastases  

International Nuclear Information System (INIS)

Five unusual cases of cystic angiomatosis of bone which presented with the radiologic appearance of osteoblastic lesions are reported. Three patients were female (ages 37, 41, and 65 years) and two were male (ages 24 and 66 years). Although cystic angiomatosis of bone usually produces widespread osteolytic lesions with a honeycombed appearance in the skeletal system, multiple osteoblastic lesions mimicking metastatic osteoblastic carcinoma are sometimes seen. This radiological presentation has not been well emphasized in previous reports. Histologically, in addition to the angiomatous lesions, both mature thickened lamellar bone trabeculae and immature trabeculae of woven bone were found. In one of our patients, increasing density of the osteoblastic lesions was noted over time. One previous study has suggested that the age of the lesions of cystic angiomatosis is related to radiographic density. It is important to recognize this uncommon variant of cystic angiomatosis and to include this entity among the radiologic differential diagnoses when multiple osteoblastic lesions are encountered. (orig.)

3

Condensing osteitis of the clavicle in childhood: A rare sclerotic bone lesion  

International Nuclear Information System (INIS)

Seven children and adolescents with sclerotic and periosteal alterations of the clavicle are reported, two of them in detail. Malignancies and bacterial inflammatory processes, which were first suspected, could be excluded. Clinical and radiographic features as well as differential diagnosis are discussed, as is the pertinent literature. The etiology of this uncommon bone lesion, which is described under different names, could not be clarified. (orig.)

4

Sclerotic variant of lymphangiomatosis of bone: imaging findings at diagnosis and long-term follow-up  

Energy Technology Data Exchange (ETDEWEB)

Lymphangiomatosis is an extremely rare congenital disorder affecting visceral organs and/or the skeletal system. In bone is is usually characterized by multiple lytic lesions with a lacelike pattern and sclerotic margins of various thickness. In this case report we demonstrate the rare sclerotic variant of lymphangiomatosis. We report the development of predominantly sclerotic lesions at different sites by serial radiographs with a long-term follow-up, and show the MRI findings of lymphangiomatosis of the spine. (orig.) With 4 figs., 12 refs.

Forstner, R. [Department of Radiology, Salzburg (Austria); Datz, C. [Department of Medicine, Landeskrankenanstalten Salzburg (Austria); Dietze, O. [Department of Pathology, Landeskrankenanstalten Salzburg (Austria); Rettenbacher, L. [Department of Nuclear Medicine, Landeskrankenanstalten Salzburg (Austria)

1998-08-01

5

Evaluation of Response to Therapy in a Patient with Lung Cancer: Correlation of Sclerotic Bone Lesions with F 18 FDG PET/CT and Bone Scintigraphy  

OpenAIRE

A 64-year-old male patient with small cell lung cancer underwent Fluorine-18 fluorodeoxyglucose (F 18 FDG) positron emission tomography (PET)/CT scan which revealed multiple F 18 FDG uptake in the spine, both humeri, ribs, pelvis and proximal long bones. There was no obvious lytic or sclerotic bone destruction accompanying these lesions on CT component of the study. After the patient received six courses of chemotherapy a repeat F 18 FDG-PET/CT was performed for evaluation of therapy response...

O?zu?lker, Tamer; O?zu?lker, Filiz; Ku?c?u?ko?z Uzun, Aysun; Tatog?lu, Tar?k; O?zpac?ac?, Tevfik

2011-01-01

6

An Inflammatory Dentigerous Cyst Shows Rim Uptake on Bone Scan: A Case Report  

Energy Technology Data Exchange (ETDEWEB)

Dentigerous cysts are developmental odontogenic jaw cysts, commonly manifesting in the 2nd and 3rd decades of life. This article presents an extremely rare case of dentigerous cyst showing increased uptake in the peripheral rim on bone scan. Herein, we discuss the clinical, radiographic, and histologic features of dentigerous cysts as well as the pathological mechanism underlying their activities on the bone scan. Bone scan was a sensitive tool for detecting the biologic activity of dentigerous cyst in our case.

Son, Hye Joo; Jeong, Young Jin; Jeong, Jin Sook; Kang, Doyoung [Dong-A Univ. Medical Center, Busan (Korea, Republic of)

2014-03-15

7

Bone disease of primary hyperoxaluria in infancy  

Energy Technology Data Exchange (ETDEWEB)

A patient with primary hyperoxaluria type I in infancy is reported. He had renal insufficiency, but urolithiasis was absent. Demonstration of diffuse nephrocalcinosis by renal ultrasound contributed to early diagnosis. Prolonged survival leads to extensive extrarenal oxalate deposition. Repeated skeletal surveys showed the development and the progression of severe hyperoxaluria-related bone disease. Translucent metaphyseal bands with sclerotic margins, wide areas of rarefaction at the ends of the long bones, and translucent rims around the epiphyses and the tarsal bones were signs of disordered bone growth. Bone density generally increased with time indicating progressive sclerosis due to oxalate deposition in the previously normal bone structure. (orig.).

Ring, E.; Wendler, H.; Zobel, G. (Graz Univ. (Austria). Abt. fuer Kinderheilkunde); Ratschek, M. (Graz Univ. (Austria). Abt. fuer Pathologie)

1989-11-01

8

Bone disease of primary hyperoxaluria in infancy  

International Nuclear Information System (INIS)

A patient with primary hyperoxaluria type I in infancy is reported. He had renal insufficiency, but urolithiasis was absent. Demonstration of diffuse nephrocalcinosis by renal ultrasound contributed to early diagnosis. Prolonged survival leads to extensive extrarenal oxalate deposition. Repeated skeletal surveys showed the development and the progression of severe hyperoxaluria-related bone disease. Translucent metaphyseal bands with sclerotic margins, wide areas of rarefaction at the ends of the long bones, and translucent rims around the epiphyses and the tarsal bones were signs of disordered bone growth. Bone density generally increased with time indicating progressive sclerosis due to oxalate deposition in the previously normal bone structure. (orig.)

9

Innumerable Small Bony Nodular Sclerotic Lesions with Negative Findings on Both Bone Scintigraphy and F-18 FDG PET: Osteopoikilosis a Patient of Breast Cancer  

Energy Technology Data Exchange (ETDEWEB)

Osteopoikilosis is a rare, benign hereditary disease, which presents multiple osteosclerotic, and small round nodules in the bone. It is usually detected incidentally by radiological examination. A radionuclide bone scintigraphy is essential in distinguishing osteopoikilosis from osteoblastic metastases, because scintigraphic findings are usually normal in patients with osteopoikilosis. However, there have been no reports about F-18 fluorodeoxyglucose (FDG) PET findings in osteopoikilosis. Herein, we wish to report a case of osteopoikilosis with breast cancer, which could not be seen in either bone scintigraphy or F-18 FDG PET/CT.

Jun, Sung Min; Kim, Yong Ki; Kim, In Ju; Nam, Hyun Yeol; Kim, Bum Soo [Pusan National University Hospital, Pusan (Korea, Republic of)

2008-06-15

10

Sclerotic multiple myeloma with an unusual sunburst periosteal reaction occurring in the sternum.  

Science.gov (United States)

Multiple myeloma is a disseminated neoplastic monoclonal gammopathy that usually affects the skull, clavicle, rib, pelvis, spinal column, and proximal portions of the humerus and femur. The initial manifestation of multiple myeloma in the sternum is rare. The classic radiological presentations of multiple myeloma are multiple "punched-out" areas of bone destruction, expansile lytic lesions, and generalized osteoporosis. Primary sclerotic presentation is rare and occurs in only 3 % of cases. A sclerotic multiple myeloma with a sunburst periosteal reaction occurring in the sternum has not been reported in the English literature. We report a case of sclerotic multiple myeloma of a 49-year-old woman. In the sternum, the lesion displayed extensive sclerosis mixed with mottled lytic areas with a sunburst periosteal reaction occurring in the periphery, which radiologically mimicked an osteosarcoma. Multiple focal areas of sclerosis were also found in the right clavicle, pelvis, multiple ribs, and vertebrae. PMID:25351419

Li, Yuqing; Wu, Wenjuan; Zhang, Zekun; Ding, Yang; Latif, Mahrukh

2014-10-29

11

Sclerotic fibroma-like change in various neoplastic and inflammatory skin lesions: is sclerotic fibroma a distinct entity?  

Science.gov (United States)

Sclerotic fibroma was first described in association with Cowden's disease by Weary et al. in 1972. In 1989, Rapini and Golitz detailed 11 cases of solitary sclerotic fibroma (SFS) in the absence of Cowden's disease, suggesting the term SFS of the skin. Classic histological features include hypocellular, hyalinized bands of collagen sharply demarcated from the surrounding skin. Numerous authors have described sclerotic fibroma-like changes in other entities including melanocytic nevi, dermatofibromas, lipomas, tendon sheath fibromas, giant cell collagenomas, neurofibromas, angiofibromas, erythema elevatum diutinum, and folliculitis. Dissension has arisen, with some dermatopathologists asserting that sclerotic fibroma is just an evolutionary end-point of a previous lesion. Others contend that SFS is a distinct lesion and cite recurrent cases and/or proliferation marker studies to corroborate this view. We detail the histopathological findings of lesions consistent with the classic description of SFS and compare these to sclerotic changes observed in an intradermal nevus, blue nevus, erythema elevatum diutinum, neurofollicular hamartoma, angiofibroma, neurofibroma, accessory nipple, and dermatofibromas. Sclerotic fibroma-like change may be seen in a variety of lesions and may represent a common reaction pattern in the skin. PMID:15059222

High, Whitney A; Stewart, David; Essary, Lydia R; Kageyama, Nicole P; Hoang, Mai P; Cockerell, Clay J

2004-05-01

12

A solitary lesion of talus with mixed sclerotic and lytic changes: Rosai-Dorfman disease of 25 years' duration  

International Nuclear Information System (INIS)

Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is an unusual form of histiocytic disorder predominantly affecting children and young adults. Bone lesions are infrequent. We describe a 63-year-old woman with a solitary lesion of the talus which was misdiagnosed for 25 years. The patient never had adenopathy or other organ involvement. The radiographic findings were a mixture of sclerotic and lytic changes, an extremely rare and unusual presentation of the disease. (orig.)

13

T-tube insertion for sclerotic subglottic stenosis.  

Science.gov (United States)

T-tube insertion is effective treatment for subglottic stenosis, but it is generally difficult due to bending of the T-tube. In a 52-year-old woman with relapsing polychondritis, a T-tube was inserted after predilatation using Hegar dilators. We describe the details of our T-tube insertion methods for sclerotic subglottic stenosis. PMID:24585799

Goto, Taichiro; Kato, Ryoichi

2014-02-01

14

Peritumoral bone marrow edema accompanying benign giant cell tumor  

International Nuclear Information System (INIS)

To evaluate the frequency of peritumoral bone marrow(BM) edema accompanying benign giant cell tumor(GCT) of the appendicular bone by magnetic resonance(MR) imaging and to correlate MRI findings with those of plain radiography and bone scintigraphy. Eighteen cases of pathologically proven benign GCT of the appendicular bone were retrospectively analyzed using MR images, plain radiographs and bone scintigrams. A plain radiography was available in 15 cases, and a scintigram in six. Marrow edema was defined as peritumoral signal changes which were of homogeneous intermediate or low signal intensity(SI) onT1WI and high SI on T2WI, relative to the SI of normal BM, and homogeneous enhancement on Gd-DTPA -enhanced T1WI. The transition zone, sclerotic margin and aggressiveness of the lesion were assessed on the basis of plain radiographs. BM edema seen on MR images was correlated with plain radiographic and scintigraphic findings. 1. Peritumoral BM edema was seen on MR images in 10 of 18 cases (55.5%). 2. In 8 of 15 cases for which plain radiographs were available, MR imaging revealed BM edema. In six of these eight, transition zone was wide, while in two it was narrow. Six of seven patients without marrow edema showed a wide transition zone, and in one this was narrow. There was significant correlation between BM edema shown by MR imaging and the transition zone seen on plain radiographs (x2, p<0.05). But the aggressiveness shown by plain radiographs correlated onl shown by plain radiographs correlated only marginally while the presence of sclerotic rim did not correlate. 3. All six cases for which a bone scintigram was available showed an extended uptake pattern. In five of the six, MR imaging revealed edema. Peritumoral BM edema was frequently seen (55.5%) in the GCTs of appendicular bone; it was more often shown in association with a wide transition zone by plain radiographs.=20

15

Imaging diagnosis of the juxta-articular bone cyst  

International Nuclear Information System (INIS)

Objective: To investigate the imaging features of the juxta-articular bone cyst(intra- osseous ganglia). Methods: The imaging findings of 54 cases histopathologically confirmed were studied retrospectively. X-ray, CT, and MRI were performed in 46 eases, 30 cases, and 14 cases, respectively. Results: Of the 54 cases, 27 arised from the ankle (including multiple lesions), 16 from the knee joint, 7 from the hip joint, 1 from the proximate end of the humerus, ulna, trapezium bone, the first phalange in each, and 1 from the talus and the distal end of the tibia. There were 43 cases (44 lesions) in the ankle and knee joints, with 29 (65.9%) lesions located in the medial articular surface. Fifty-four cases had thinning sclerotic rim, showing a unilocular round osteolytic appearance in 44 cases and a multiloculated-cystic appearance with septa in 10 cases. Discontinuous articular surface were seen in 15 cases, reticular surface collapse in 1, gas density in 3 and fluid-fluid plane in 1. (1) On x-ray films, 46 cases (47 lesions) with well-defined sclerotic rim revealed round, arch or irregular lyric areas at the adjacent articular surface. The fissures were found at the adjacent articular surface in 6 lesions. No joint spaces were abnormal. (2)On CT, 30 cases with sclerotic rim showed round in 19 lesions, arch in 3, and irregular in 8. The fissures were seen at the adjacent articular surface in 14 lesions. The density showed homogeneous in 27 lesions, and gas existed in 3. (3)s in 27 lesions, and gas existed in 3. (3) Fourteen cases (15 lesions)showed hypointense to isointense signal on MR T1WI and hyperintense signal on T2WI. Fluid-fluid plane was found in 1 case. The fissures were observed at the adjacent articular surface in 8 lesions. 7 cases showed swelling soft tissue. Conclusion: The characteristic locations combined with the typical imaging features may suggest the diagnosis of jaxta-articular bone cyst. (authors)

16

A solitary lesion of talus with mixed sclerotic and lytic changes: Rosai-Dorfman disease of 25 years' duration  

Energy Technology Data Exchange (ETDEWEB)

Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is an unusual form of histiocytic disorder predominantly affecting children and young adults. Bone lesions are infrequent. We describe a 63-year-old woman with a solitary lesion of the talus which was misdiagnosed for 25 years. The patient never had adenopathy or other organ involvement. The radiographic findings were a mixture of sclerotic and lytic changes, an extremely rare and unusual presentation of the disease. (orig.)

Abdelwahab, Ibrahim Fikry [Department of Radiology, New York Methodist Hospital Affiliated with Weill Medical College of Cornell University, 506 Sixth Street, NY 11215, Brooklyn (United States); Klein, Michael J. [Department of Pathology, Mount Sinai Medical Center, 1 Gustave Levy Place, NY 10029, New York (United States); Springfield, Dempsey S. [Department of Orthopedics, Mount Sinai Medical Center, 1 Gustave Levy Place, NY 10029, New York (United States); Hermann, George [Department of Radiology, Mount Sinai Medical Center, 1 Gustave Levy Place, NY 10029, New York (United States)

2004-04-01

17

Dopamine-Mediated Sclerotization of Regenerated Chitin in Ionic Liquid  

Directory of Open Access Journals (Sweden)

Full Text Available Chitin is a promising structural material for biomedical applications, due to its many advantageous properties and abundance in nature. However, its usage and development in the biomedical field have been stagnant, because of chitin’s poor mechanical properties in wet conditions and the difficulties in transforming it into an applicable form. To overcome these challenges, we created a novel biomimetic chitin composite. This regenerated chitin, prepared with ionic liquid, showed improved mechanical properties in wet conditions by mimicking insect cuticle and squid beak sclerotization, i.e., catechol-meditated cross-linking. By ionic liquid-based heat treatment, dopamine oxidation produced melanin-like compounds and dopamine-meditated cross-links without any solvent evaporation and oxidant utilization. The dopamine-meditated sclerotization increased the ultimate tensile strength (UTS of the regenerated chitin by 2.52-fold, measured after six weeks of phosphate-buffered saline (PBS submersion. In addition, the linear swelling ratio (LSR of the chitin film was reduced by about 22%. This strategy raises a possibility of using regenerated chitin as an artificial hard tissue in wet conditions.

Dongyeop X. Oh

2013-09-01

18

Multifocal sclerotic BCG spondylitis in a 13-year-old girl  

International Nuclear Information System (INIS)

A case is reported of multifocal BCG osteomyelitis in a 13-year-old girl. The lesions in the skull, ribs and in several vertebrae were mainly sclerotic and healed with antituberculotic therapy. The case is unusual because of the late onset, sclerotic changes, and involvement of the spine. (orig.)

19

Micromorphological and hardness analyses of human and bovine sclerotic dentin: a comparative study  

Directory of Open Access Journals (Sweden)

Full Text Available The purpose of this study was to test the hypothesis that both human and bovine sclerotic dentin have similar hardness properties, in addition to similar micromorphological characteristics. Sixteen teeth (8 human and 8 bovine exhibiting exposed dentin in the incisal edge and showing characteristics typical of sclerosis were used. Vickers surface microhardness testing was conducted. Three areas of the dentin surface of each specimen were selected. All teeth were processed for scanning electron microscopy in order to estimate the amount (in percentage of solid dentin on the sclerotic dentin surface. The data were compared by Student's t test (? = 0.05. The micromorphological and microhardness data were compared by Pearson's linear correlation test (? = 0.05. The mean percentages of solid dentin of human and bovine sclerotic dentin were similar (human 90.71 ± 0.83 and bovine 89.08 ± 0.81, p = 0.18. The mean microhardness value (VHN of human sclerotic dentin was significantly higher than that of bovine sclerotic dentin (human 45.26 ± 2.92 and bovine 29.93 ± 3.83, p = 0.006. No correlation was found between the microhardness values and the amount of solid dentin in the sclerotic dentin, irrespective of the species considered (human R² = 0.0240, p = 0.714; bovine R² = 0.0017, p = 0.923; and combined R² = 0.038, p = 0.46. We concluded that although both bovine and human sclerotic dentin present a similar amount of solid tissue, human sclerotic dentin presents higher microhardness than bovine sclerotic dentin.

Gisela Muassab Castanho

2011-06-01

20

Micromorphological and hardness analyses of human and bovine sclerotic dentin: a comparative study  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The purpose of this study was to test the hypothesis that both human and bovine sclerotic dentin have similar hardness properties, in addition to similar micromorphological characteristics. Sixteen teeth (8 human and 8 bovine) exhibiting exposed dentin in the incisal edge and showing characteristics [...] typical of sclerosis were used. Vickers surface microhardness testing was conducted. Three areas of the dentin surface of each specimen were selected. All teeth were processed for scanning electron microscopy in order to estimate the amount (in percentage) of solid dentin on the sclerotic dentin surface. The data were compared by Student's t test (? = 0.05). The micromorphological and microhardness data were compared by Pearson's linear correlation test (? = 0.05). The mean percentages of solid dentin of human and bovine sclerotic dentin were similar (human 90.71 ± 0.83 and bovine 89.08 ± 0.81, p = 0.18). The mean microhardness value (VHN) of human sclerotic dentin was significantly higher than that of bovine sclerotic dentin (human 45.26 ± 2.92 and bovine 29.93 ± 3.83, p = 0.006). No correlation was found between the microhardness values and the amount of solid dentin in the sclerotic dentin, irrespective of the species considered (human R² = 0.0240, p = 0.714; bovine R² = 0.0017, p = 0.923; and combined R² = 0.038, p = 0.46). We concluded that although both bovine and human sclerotic dentin present a similar amount of solid tissue, human sclerotic dentin presents higher microhardness than bovine sclerotic dentin.

Gisela Muassab, Castanho; Márcia Martins, Marques; Juliana Barbosa, Marques; Maitê André, Camargo; Antonio Alberto De, Cara.

2011-06-01

21

Vertebral sarcoidosis: demonstration of bone involvement by computerized axial tomography  

International Nuclear Information System (INIS)

A report is given of a rare case of vertebral sarcoidosis with negative conventional spinal x-ray films, yet with typical cystic lesions of the spine found incidentally during abdominal computerized axial tomography (CAT). The patient was a 28-year-old black man, who was admitted for evaluation of a 1 1/2-year history of diffuse myalgias, intermittent fever to 102 F orally, bilateral hilar adenopathy, and leukopenia. A technetium polyphosphate bone scan revealed diffuse areas of increased uptake over the sternum, entire vertebral column, and pelvis. Conventional x-ray films of the cervical, thoracic, and lumbar spine, and an AP view of the pelvis were all normal. Chest x-ray film revealed only bilateral hilar adenopathy. During the course of an extensive negative evaluation for infection, an abdominal CAT scan was done, showing multiple, small, sclerotic-rimmed cysts at multiple levels of the lower thoracic and lumbar spine. Bone marrow biopsy revealed only changes consistent with anemia of chronic disease. Mediastinal lymph node biopsy revealed noncaseating granulomas. A tentative diagnosis of sarcoidosis was made, and treatment with prednisone, isoniazid and rifampin was begun. Within two weeks of initiation of prednisone therapy, the patient was symptom-free. A repeat technetium polyphosphate bone scan revealed only a small residual area of mildly increased uptake over the upper thoracic vertebrae

22

Microorbitalism: a technique for orbital rim expansion.  

Science.gov (United States)

A simple technique for orbital aperture expansion to facilitate placement of ocular prostheses is described. Both superolateral and inferolateral orbital margins are released by means of a single burr hole craniectomy of the frontosphenoid bone behind the orbital process of the frontal bone. Vertical and horizontal marginal lengthenings are performed by a rotatory displacement of one bone segment alongside the other. The expanded osseous aperture is secured with wire and plate-and-screw fixation following a supraorbital rim craniectomy to allow an adequate fit. The result provides for easier access of ocular prostheses and tissue expanders. The method has been applied to a series of patients with microorbitalism due to unilateral or bilateral congenital anophthalmia over the past 3 years without complication and with excellent results. Three-dimensional re-formatted CT reconstructions of the craniofacial skeleton are shown preoperatively and postoperatively. PMID:1896532

Elisevich, K; Bite, U; Colcleugh, R

1991-10-01

23

The use of qualitative and quantitative polymerase chain reactions for diagnosis of cytomegalovirus infections in bone marrow and kidney transplant recipients / Desenvolvimento e aplicação de PCRs quali-quantitativas para diagnóstico de citomegalovirose em transplantados de rim e medula óssea  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese O objetivo deste trabalho foi testar uma PCR qualitativa e uma PCR semiquantitativa para CMV para determinar a carga de CMV nos leucócitos de pacientes transplantados de medula óssea e transplantados de rim. Trinta e três pacientes TMO e 35 TR participaram deste estudo. O DNA foi testado pela PCR qu [...] alitativa utilizando primers que amplificam parte do gene gB de CMV. As cargas de CMV das amostras positivas foram determinadas pela PCR semi-quantitativa utilizando como controle plasmídios quantificáveis inseridos com parte do gene gB de CMV. A sensibilidade do teste foi de 867 plamídios/µg DNA. Cargas de CMV entre 2.118 e 72.443 copias/µg DNA foram observadas em 12,1% dos TMO entre 1,246 e 58,613 cópias/µg DNA foram observadas em 22,9% dos TR. Futuros estudos, com maiores casuísticas são necessários para confirmar a utilidade desta PCR semiquantitativa para CMV em pacientes transplantados. Abstract in english The purpose of this work was to test a cytomegalovirus qualitative PCR and a semi-quantitative PCR on the determination of CMV load in leukocytes of bone marrow and kidney transplanted (RT) patients. Thirty three BMT and 35 RT patients participated of the study. The DNA was subjected to a qualitativ [...] e PCR using primers that amplify part of CMV gB gene. CMV load of positive samples was determined by a semi-quantitative PCR using quantified plasmids inserted with part of the gB gene of CMV as controls. The sensitivity of the test was determined to be 867 plasmid copies/µg DNA. CMV loads between 2,118 and 72,443 copies/µg DNA were observed in 12.1% BMT recipients and between 1,246 and 58,613 copies/µg DNA in 22.9% RT recipients. Further studies are necessary to confirm the usefulness of this CMV semi-quantitative PCR in transplanted patients.

Lauro Juliano, Marin; Aldo Albuquerque, Cunha; Victor Hugo, Aquino; Luiz Tadeu Moraes, Figueiredo.

2004-03-01

24

CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS  

Directory of Open Access Journals (Sweden)

Full Text Available Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fingers have not been reported to date. Mucin deposition in the sclerotic skin may be a predisposing factor in the induction of myxoid cyst on the scleroderma finger in our patient.

Taeko Nakamura-Wakatsuki

2013-10-01

25

Ewing's sarcoma of the tarsal bone  

International Nuclear Information System (INIS)

The Ewing's sarcoma comprises approximately less than 10 percent of malignant bone tumors and 5 percent of all bone tumors, occurs in almost all bones of the body, and presents a widely divergent roentgenographic manifestations. The tarsal bones are involved only 2 percent in the Ewing's sarcoma. Two cases experienced by authors and ten cases published in literatures of Ewing's sarcoma of the tarsal bone were analyzed retrospectively. The result were as follows: 1. Of the tarsal bones, the calcaneus was 7 cases, the talus 4 cases, cuneiform 1 case. 2. Female was affected more commonly than male, the ratio being 4 to 1 in the tarsal bones. 3. About sixty percent of total cases in the tarsal bones had evidence of diffuse sclerotic pattern. All the cases of the talus had evidence of diffuse sclerotic pattern. 4. The diseases to be considered in differential diagnosis are as follows: avascular necrosis, tuberculous osteomyelitis, osteosarcoma, and pyogenic osteomyelitis. 5. The diffuse sclerosis radiographically showed a close relation with dead bone resulting from avascular necrosis due to tumor infiltration histologically. Periosteal reactive new bone and osteoid deposition on the dead bone were also correlated with diffuse sclerosis. 6. Because it is difficult to differentiate sclerotic lesions in the tarsal bones by radiographic methods alone, all such lesions should be subject to biopsy as early as possible

26

Pupal cuticle proteins of Manduca sexta: characterization and profiles during sclerotization.  

Science.gov (United States)

Proteins in pupal abdominal cuticle of the tobacco hornworm, Manduca sexta, were characterized during the pre-ecdysial and post-ecdysial periods of sclerotization and endocuticle formation. Protein extractability decreased dramatically as the cuticle became sclerotized through 6 h post-ecdysis, but increased rapidly from 9 to 48 h as endocuticular layers were secreted. Nearly 100 proteins that were extracted from pre-ecdysial cuticle became largely insoluble during sclerotization. Three major proteins in this group destined to become exocuticle had apparent molecular masses (Mapp) of 20, 27 and 36 kDa, and were designated MS-PCP20, MS-PCP27, and MS-PCP36. Amino acid analysis revealed glycine to predominate in all three proteins, and alanine, aspartate, glutamate, proline and serine were also relatively abundant. Histidine residues, which provide sites for adduct and cross-link formation with quinone metabolites of N-beta-alanyldopamine during sclerotization of pupal cuticle, ranged from 2 to 3 mol %. N-Terminal amino acid analysis of MSPC-20 and MSPC-36 also revealed some sequence similarities indicating they may be related. An almost entirely new group of proteins appeared by 9 h as endocuticule secretion began, and these increased in abundance through 48 h post-ecdysis. Two of these were major proteins with Mapps of 33 and 34 kDa, and they also had close similarities in their N-terminal amino acid sequences. This study showed that the large number of proteins secreted into the presumptive exocuticle of the pupa before ecdysis are involved in sclerotization reactions and as a consequence become largely insoluble. The epidermis then switches to the secretion of an entirely new group of proteins that are involved in formation of the endocuticle. PMID:10646967

Hopkins, T L; Krchma, L J; Ahmad, S A; Kramer, K J

2000-01-01

27

Singular structures on liquid rims  

Science.gov (United States)

This experimental note is concerned with a new effect we discovered in the course of studying water hammering phenomena. Namely, the ejecta originating from the solid plate impact on a water surface brings about a liquid rim at its edge with the fluid flowing towards the rim center and forming a singular structure resembling a "pancake." Here, we present the experimental observations and a qualitative physical explanation for the effect, which proves to be fundamental to the situation when the size and speed of the impacting body are such that the capillary effects become important.

Mayer, Hans C.; Krechetnikov, Rouslan

2014-03-01

28

Parietal Epithelial Cells Participate in the Formation of Sclerotic Lesions in Focal Segmental Glomerulosclerosis  

OpenAIRE

The pathogenesis of the development of sclerotic lesions in focal segmental glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or parietal epithelial cells (PECs) to determine whether PECs contribute to sclerosis. In three distinct models of FSGS (5/6-nephrectomy + DOCA-salt; the murine transgenic chronic Thy1.1 model; or the MWF rat) and in human biopsies, the primary injury to induce FSGS associated with focal activation of PECs and the formation of cellular ad...

Smeets, Bart; Kuppe, Christoph; Sicking, Eva-maria; Fuss, Astrid; Jirak, Peggy; Kuppevelt, Toin H.; Endlich, Karlhans; Wetzels, Jack F. M.; Gro?ne, Hermann-josef; Floege, Ju?rgen; Moeller, Marcus J.

2011-01-01

29

Micromorphological and hardness analyses of human and bovine sclerotic dentin: a comparative study  

OpenAIRE

The purpose of this study was to test the hypothesis that both human and bovine sclerotic dentin have similar hardness properties, in addition to similar micromorphological characteristics. Sixteen teeth (8 human and 8 bovine) exhibiting exposed dentin in the incisal edge and showing characteristics typical of sclerosis were used. Vickers surface microhardness testing was conducted. Three areas of the dentin surface of each specimen were selected. All teeth were processed for scanning electro...

Gisela Muassab Castanho; Márcia Martins Marques; Juliana Barbosa Marques; Maitê André Camargo; Antonio Alberto de Cara

2011-01-01

30

DE 1 RIMS operational characteristics  

Science.gov (United States)

The Retarding Ion Mass Spectrometer (RIMS) on the Dynamics Explorer 1 spacecraft observes both the thermal and superthermal (50 eV) ions of the ionosphere and inner magnetosphere. It is capable of measuring the detailed species distribution function of these ions in many cases. It was equipped with an integral electrometer to permit in-flight calibration of the detector sensitivities and variations thereof. A guide to understanding the RIMS data set is given. The reduction process from count rates to physical quantities is discussed in some detail. The procedure used to establish in-flight calibration is described, and results of a comparison with densities from plasma wave measurements are provided. Finally, a discussion is provided of various anomalies in the data set, including changes of channeltron efficiency with time, spin modulation of the axial sensor heads, apparent potential differences between the sensor heads, and failures of the radial head retarding potential sweep and of the -Z axial head aperture plane bias. Studies of the RIMS data set should be conducted only with a thorough awareness of the material presented here, or in collaboration with one of the scientists actively involved with RIMS data analysis.

Olsen, R. C.; Comfort, R. H.; Chandler, M. O.; Moore, T. E.; Waite, J. H., Jr.; Reasoner, D. L.; Biddle, A. P.

1985-01-01

31

In vitro evaluation of the microhardness of normal and sclerotic bovine dentin  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction:The literature shows different characteristics between normal and sclerotic dentin.Hardness is a property that has been very used to compare restorative materials and biological tissues.Objective: The aim of this study was to compare the hardness clinical characteristics between the normal and the sclerotic bovine dentin, through the microhardness test.Material and methods: 20 bovine teeth were divided in two groups: GI (normal and GII (with characteristics of sclerosis.The teeth were mounted in acrylic resin cylinders with exposure of dentin along the incisal edges. The specimens received finishing and polishing following by storage in distilled water at ambient temperature for 7 days.Microhardness measurements were made using a Vickers indenter microhardness tester under a load of 50 gf for 45 s.In this study 3 areas per specimen were selected and each specimen were selected and each area received 5 indentations, resulting in 15 indentations per specimen. Results: The data were statistically processed using the Student’s t-test.The level of significance was 5%. The results showed no significant differences between the mean values of the two groups (GI: 36.82±9.45; GII:32.4±12.2 (p = 0.383.Conclusion:The normal bovine dentin presented similar microhardness Vickers values to the sclerotic bovine dentin.

Gisela Muassab CASTANHO

2009-06-01

32

Anterior glenoid rim fracture: the value of helical CT with threedimensional reconstruction and electronic humeral disarticulation  

Directory of Open Access Journals (Sweden)

Full Text Available Objectives: To show a new three-dimensional reconstructiontechnique based on helical computed tomography images withelectronic humeral disarticulation in anterior glenoid rim fractures,correlating the anatomic specimen with simulation of an anteriorglenoid rim fracture, as well as evaluating the extension of thefracture, the bone fragment position and distance in relation to theglenoid cavity in six patients. Methods: One scapula and onehumerus with no signs of fracture or congenital malformationswere placed in anatomical position using an adhesive tape aftersimulating an anterior glenoid rim fracture made by an osteotome.Helical CT imaging was acquired and three-dimensionalreconstructions were made based on these images, with andwithout electronic humeral disarticulation. The bone fragment waslocated, measured and its position in relation to the glenoid cavitywas assessed. Six patients with anterior glenoid rim fracture weresubmitted to CT of the shoulder using the same parameters asthose applied to the anatomic specimen. Results: In the anatomicspecimen and in all six patients the bone fragment was clearlydemonstrated; bone fragment measurements in the anatomicspecimen and in three-dimensional reconstructions wereequivalent. The fragment was better demonstrated in the imagestaken with electronic humeral disarticulation, particularly in thefrontal view of the glenoid cavity as observed in all six patients.Conclusion: We concluded that our experiment with the anatomicspecimen and the study of six patients allow us to state that thistechnique is safe and accurate to demonstrate the extension, sizeand location of the bone fragment in anterior glenoid rim fractures,and it provides essential elements for therapeutic planning.

Heverton César de Oliveira

2003-06-01

33

Linhas escleróticas metafisárias em crianças e adolescentes em uso de alendronato / Sclerotic metaphyseal lines in children and adolescents treated with alendronate  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: Os bisfosfonatos inibem a reabsorção óssea pela interferência na ação dos osteoclastos. Dentre os efeitos adversos, as linhas escleróticas em metáfise de ossos longos são descritas como principal alteração radiográfica na faixa etária pediátrica. OBJETIVO: Avaliar a frequência de alteraç [...] ões radiográficas causadas pelo alendronato utilizado em crianças e adolescentes com baixa densidade óssea ou calcinose. PACIENTES E MÉTODOS: Foi realizado um estudo do tipo coorte retrospectiva analisando-se prontuários de 21 pacientes que fizeram uso de alendronato semanal por no mínimo 10 meses. Os pacientes realizaram radiografias de ossos longos antes do início do alendronato e aproximadamente um ano após o seu uso. RESULTADOS: Onze pacientes (52,3%) apresentaram linhas escleróticas em metáfise dos ossos longos. A localização mais frequente foi em tíbia (8/11 pacientes), seguida de fêmur (7/11), úmero (6/11), rádio (4/11), ulna (3/11) e fíbula (2/11). Nenhum paciente apresentou regressão das alterações radiográficas durante o tempo de evolução (até 1,1 ano após a suspensão do alendronato). CONCLUSÃO: Se usado com critério, o alendronato é seguro e as alterações radiográficas não mostraram ter um significado mais importante. Abstract in english INTRODUCTION: Bisphosphonates inhibit bone resorption by interfering with the action of osteoclasts. Among the adverse effects, sclerotic lines observed in the metaphysis of long bones have been described as the main imaging finding in pediatric patients. OBJECTIVE: To evaluate the frequency of radi [...] ographic changes caused by alendronate in children and adolescents with low bone density or calcinosis. PATIENTS AND METHODS: We conducted a cross-sectional study with 21 patients who were treated with once-weekly alendronate for at least 10 months. Patients underwent x-rays of long bones before the start of alendronate and approximately one year after its use. RESULTS: Eleven patients (52.3%) had sclerotic lines in the metaphysis of long bones. The most frequent site was the tibia (8/11 patients), followed by the femur (7/11), humerus (6/11), radius (4/11), ulna (3/11), and fibula (2/11). Regression of radiographic changes during the study period (up to 1.1 years after discontinuation of alendronate) was not observed. CONCLUSION: If used carefully, alendronate is safe and radiographic changes have not been shown to be clinically relevant.

Érika C.C., Silva; Maria Teresa R.A., Terreri; Tania C.M. de, Castro; Cássia P.L., Barbosa; Artur R.C., Fernandes; Maria Odete E., Hilário.

2010-06-01

34

Imaging features of hemangioma in the long bone  

International Nuclear Information System (INIS)

Objective: To explore the imaging features of hemangioma in the long bone and improve the diagnostic level of this disease. Methods: The X-ray (14 cases), CT (9 cases) and MRI (6 cases) findings of 18 patients with histologically proven hemangioma in the long bone after surgery were retrospectively reviewed. Results: Ten tumors occurred in medullary cavity or bone end (medullary type), 6 on the surface of bone (periosteal type) and 3 in cortex (intracortical type). X-ray findings: among 8 cases of medullary type, 3 showed honeycomb appearance, 3 lytic areas with sclerotic borders, one purely osteolytic changes, and 1 frosted glass; 3 cases of periosteal type showed sclerosis and thickening of the underlying cortex; 3 cases of intracortical type showed well defined osteolytic foci. CT findings: among 6 cases of medullary type, 5 appeared as expansile lytic lesion with uneven selerotic rim (3 cases) orhoneycomb appearance (2 cases), 1 cribriform appearance in the cortical bone, 2 periostealnew bone formation in vertical radiation pattern; 1 ground-glass appearance; among 2 cases of periosteal type-one showed regular cortical thickening, and the other irregular periosteal proliferation with marrowing of medullarycavity; 1 case of intracortical type showed density similar to that of soft tissue, with cortical thickening and expansion. MRI findings: 2 appeared as well-defined lesions with low signal intensity on T1WI and high signal intensity on T2WI; 1 appeared as ill-defined lesion with low to intermediate signal intensity on T1WI and T2WI. One showed breakthrough of cortex and formation of soft, tissue mass with low signal intensity on T1WI and high signal on T2WI. Two showed thickening of periosteum with intermediate signal intensity in one of them and very low signal intensity in the other. Two showed abnormal signal intensity in surrounding muscles, which was high on T2WI and intermediate on T1WI. Conclusions: The soap-bubble or honeycomb appearance is the typical radiographic finding of hemangioma in long bone. CT and MRI can provide useful information for the diagnosis of hemangioma in long bone. (authors)

35

RIM  

SCPinfonet

Group: This meeting of the Environment Management Group (EMG) is expected to consider the strategic directions ...for the EMG, and the contribution of the EMG to the follow up of the UN ...November 2012 location: UN Headquarters, New York contact: EMG Secretariat phone: +41-22- 917-8693 fax: +

36

Collagenous fibroma (desmoplastic fibroblastoma) of the orbital rim.  

Science.gov (United States)

A 40-year-old woman with left periorbital swelling for 1 month presented without diplopia or change in vision. Imaging studies revealed a 1-cm mass at the frontozygomatic junction at the orbital rim with slight bony erosion and spiculation. The lesion was applied to the periosteum and was excised along with a portion of the bony orbital rim. Histopathology revealed elongated and stellate fibroblasts within a dense collagenous matrix. Vimentin and Masson trichrome staining was consistent with a collagenous fibroma, a rare tumor that has, only once before, been reported in the orbit in the lacrimal fossa region. The current collagenous fibroma arose from the periosteum to grow exophytically, causing minimal bone changes. A literature review shows that this condition predominantly affects middle-aged and older adults rather than children. PMID:23446303

Stacy, Rebecca C; Jakobiec, Frederick A; Fay, Aaron

2013-01-01

37

Imaging appearance of bone tumors of the maxillofacial region  

OpenAIRE

This paper reviews the imaging appearance of benign and malignant bone tumors of the maxillofacial region. A benign bone tumor commonly appears as a well circumscribed lesion. The matrix of the tumor may be calcified or sclerotic. Malignancies often display aggressive characteristics such as cortical breakthrough, bone destruction, a permeative pattern and associated soft-tissue masses. Computed tomography scan is an excellent imaging modality for accurate localization of the lesion, characte...

Ahmed Abdel Khalek Abdel Razek

2011-01-01

38

The effects of hydroxyapatite coating and bone allograft on fixation of loaded experimental primary and revision implants  

DEFF Research Database (Denmark)

We used our established experimental model of revision joint replacement to examine the roles of hydroxyapatite coating and bone graft in improving the fixation of revision implants. The revision protocol uses the Søballe micromotion device in a preliminary 8-week period of implant instability for the presence of particulate polyethylene. During this procedure, a sclerotic endosteal bone rim forms, and a dense fibrous membrane is engendered, having macrophages with ingested polyethylene and high levels of inflammatory cytokines. At the time of revision after 8 weeks, the cavity is revised with either a titanium alloy (Ti) or a hydroxyapatite (HA) 6.0 mm plasma-sprayed implant, in the presence or absence of allograft packed into the initial 0.75 mm peri-implant gap. The contralateral limb is subjected to primary surgery with the same implant configuration, and serves as control. 8 implants were included in each of the 8 treatment groups (total 64 implants in 32 dogs). The observation period was 4 weeks after revision. Outcome measures are based on histomorphometry and mechanical pushout properties. The revision setting was always inferior to its primary counterpart. Bone graft improved the revision fixation in all treatment groups, as also did the HA coating. The sole exception was revision-grafted HA implants, which reached the same fixation as primary Ti and HA grafted implants. The revision, which was less active in general, seems to need the dual stimulation of bone graft and HA implant surface, to obtain the same level of fixation associated with primary implants. Our findings suggest that the combination of HA implant and bone graft may be of benefit in the clinical revision implant setting.

SØballe, Kjeld; Mouzin, Olivier R G

2003-01-01

39

Three-dimensional trabecular bone architecture of the lumbar spine in bone metastasis from prostate cancer: comparison with degenerative sclerosis  

International Nuclear Information System (INIS)

Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. The objective of this study was to clarify the three-dimensional (3D) trabecular bone microstructure in bone metastasis from prostate cancer by comparison with normal and degenerative sclerotic bone lesions, using microcomputed tomography (micro-CT). A total of 32 cancellous bone samples were excised from the lumbar spine of six autopsy patients: 15 metastatic samples (one patient), eight degenerative sclerotic samples (four patients) and the rest from normal sites (three patients). The samples were serially scanned cross-sectionally by micro-CT with a pixel size of 23.20 ?m, slice thickness of 18.56 ?m, and image matrix of 512 x 512. Each image data set consisted of 250 consecutive slices. The volumes of interest (96 x 96 x 120 voxels) were defined in the original image sets and 3D indices of the trabecular microstructure were determined. The trabecular thickness (Tb.Th) in degenerative sclerotic lesions was significantly higher than that in normal sites, whereas no significant difference was observed in trabecular number (Tb.N). By contrast, in metastatic lesions, the Tb.N was significantly higher with increased bone volume fraction (BV/TV) than in normal sites, and no significant difference was found in Tb.Th. The characteristics of the trabecular surface in the metastatic samples showed concave structural elements with an increase in BV/TV, indicating osteolysis of the trabecular bndicating osteolysis of the trabecular bone. In 3D reconstructed images, increased trabecular bone with an irregular surface was observed in samples from metastatic sites, which were uniformly sclerotic on soft X-ray radiographs. These results support, through 3D morphological features, the strong bone resorption effect in bone metastasis from prostate cancer. (orig.)

40

Three-dimensional trabecular bone architecture of the lumbar spine in bone metastasis from prostate cancer: comparison with degenerative sclerosis  

Energy Technology Data Exchange (ETDEWEB)

Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. The objective of this study was to clarify the three-dimensional (3D) trabecular bone microstructure in bone metastasis from prostate cancer by comparison with normal and degenerative sclerotic bone lesions, using microcomputed tomography (micro-CT). A total of 32 cancellous bone samples were excised from the lumbar spine of six autopsy patients: 15 metastatic samples (one patient), eight degenerative sclerotic samples (four patients) and the rest from normal sites (three patients). The samples were serially scanned cross-sectionally by micro-CT with a pixel size of 23.20 {mu}m, slice thickness of 18.56 {mu}m, and image matrix of 512 x 512. Each image data set consisted of 250 consecutive slices. The volumes of interest (96 x 96 x 120 voxels) were defined in the original image sets and 3D indices of the trabecular microstructure were determined. The trabecular thickness (Tb.Th) in degenerative sclerotic lesions was significantly higher than that in normal sites, whereas no significant difference was observed in trabecular number (Tb.N). By contrast, in metastatic lesions, the Tb.N was significantly higher with increased bone volume fraction (BV/TV) than in normal sites, and no significant difference was found in Tb.Th. The characteristics of the trabecular surface in the metastatic samples showed concave structural elements with an increase in BV/TV, indicating osteolysis of the trabecular bone. In 3D reconstructed images, increased trabecular bone with an irregular surface was observed in samples from metastatic sites, which were uniformly sclerotic on soft X-ray radiographs. These results support, through 3D morphological features, the strong bone resorption effect in bone metastasis from prostate cancer. (orig.)

Tamada, Tsutomu; Sone, Teruki; Imai, Shigeki; Kajihara, Yasumasa; Fukunaga, Masao [Kawasaki Medical School, Department of Radiology, Kurashiki, Okayama (Japan); Jo, Yoshimasa [Kawasaki Medical School, Department of Urology, Kurashiki, Okayama (Japan)

2005-03-01

41

Cerebral abscess with multiple rims on MRI  

Energy Technology Data Exchange (ETDEWEB)

We present a patient with multiple brain abscesses caused by Nocardia asteroides. On T2-weighted MRI, multiple concentric rims were seen in the abscess, which could be a finding specific for infection. The rims may be due to organization of the necrotic debris and phagocytoses by macrophages in the capsule. (orig.) With 2 figs., 16 refs.

Pyhtinen, J.; Paeaekkoe, E.; Jartti, P. [Department of Diagnostic Radiology, University of Oulu (Finland)

1997-12-01

42

Vertebral body enhancement mimicking sclerotic osseous lesions in the setting of bilateral brachiocephalic vein thrombosis.  

Science.gov (United States)

Contrast enhancement of the vertebral body marrow may be seen secondary to collateral venous blood flow via the vertebral venous plexus in the setting of superior vena cava obstruction. We report a 48-year-old woman presenting with bilateral brachiocephalic vein obstruction and multilevel thoracic spine hyperdensities as seen on venous-phase CT angiography (CTA), initially concerning for sclerotic neoplastic lesions. A contrast-enhanced CT of the neck obtained 1 day prior to the chest CTA did not demonstrate any osseous abnormality, and inspection of the chest CTA demonstrated filling of perivertebral venous collateral vessels. The abnormal vertebral body enhancement was therefore feltsecondary to retrograde collateral venous flow via the basivertebral venous plexus in the setting of functional SVC obstruction. Vertebral body enhancement should be considered in patients with thoracic central venous obstruction when enhancement or apparent sclerosis of the vertebral bodies is seen on CTA. PMID:25425344

Berritto, Daniela; Abboud, Salim; Kosmas, Christos; Riherd, Daniel; Robbin, Mark

2015-02-01

43

CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts: preliminary results  

International Nuclear Information System (INIS)

Objective: To evaluate CT-guided once-through bilateral percutaneous needle puncturing, aspiration and injection of sclerotic agents (ethanol) in treating bilateral multiple renal cysts. Methods: CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy was performed in 19 patients with bilateral multiple renal cysts. First, under CT guidance the puncture points and puncture routs were decided, then, puncturing, aspiration, rinsing and ethanol injection of the cysts were taken place by turn. The clinical results were analyzed. Results: bilateral percutaneous needle puncturing sclerotic therapy was successfully completed in all 19 cases. The whole procedure was well tolerated by all patients. The mean operative time was 23 minutes with a range of 20-35 minutes. No severe complications occurred. Conclusion: With proficient manipulation, CT-guided bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts can be smoothly carried out. The technique can reduced the number of sclerotherapy times, cut down the medical expenses and, therefore, get twofold results with half the effort. (authors)

44

Imaging appearance of bone tumors of the maxillofacial region  

Directory of Open Access Journals (Sweden)

Full Text Available This paper reviews the imaging appearance of benign and malignant bone tumors of the maxillofacial region. A benign bone tumor commonly appears as a well circumscribed lesion. The matrix of the tumor may be calcified or sclerotic. Malignancies often display aggressive characteristics such as cortical breakthrough, bone destruction, a permeative pattern and associated soft-tissue masses. Computed tomography scan is an excellent imaging modality for accurate localization of the lesion, characterization of the tumor matrix and detection of associated osseous changes such as bone remodeling, destruction or periosteal reaction. Magnetic resonance imaging is of limited value in the evaluation of maxillofacial bone tumors.

Ahmed Abdel Khalek Abdel Razek

2011-01-01

45

Asymptotic analysis of the dewetting rim.  

Science.gov (United States)

Consider a film of viscous liquid covering a solid surface, which it does not wet. If there is an initial hole in the film, the film will retract further, forming a rim of fluid at the receding front. We calculate the shape of the rim as well as the speed of the front using lubrication theory. We employ asymptotic matching between the contact line region, the rim, and the film. Our results are consistent with simple ideas involving dynamic contact angles and permit us to calculate all free parameters of this description, previously unknown. PMID:21230583

Snoeijer, Jacco H; Eggers, Jens

2010-11-01

46

Asymptotic analysis of the dewetting rim  

OpenAIRE

Consider a film of viscous liquid covering a solid surface, which it does not wet. If there is an initial hole in the film, the film will retract further, forming a rim of fluid at the receding front. We calculate the shape of the rim as well as the speed of the front using lubrication theory. We employ asymptotic matching between the contact line region, the rim, and the film. Our results are consistent with simple ideas involving dynamic contact angles and permit us to calculate all free pa...

Snoeijer, Jacco H.; Eggers, Jens

2010-01-01

47

High-precision thorium RIMS for geochemistry  

International Nuclear Information System (INIS)

We present our latest results in the development of resonance ionization mass spectrometry (RIMS) using cw lasers to measure isotope ratios of importance in geochemistry and geochronology. The RIMS method provides a higher ionization efficiency than thermal ionization allowing analysis of smaller sample sizes, while maintaining equivalent internal precision. The bias introduced in 230/232Th ratio measurements by the RIMS method when using narrow-band and broad-band lasers is discussed. Spectra of 239Th, which can be used as an internal standard, are also presented

48

Selected case from the Arkadi M. Rywlin International Pathology Slide Seminar: sclerotic (fibroma-like) lipoma, dorsum of right hand.  

Science.gov (United States)

Approximately 26 sclerotic lipomas have been reported since Zelger and colleagues' 1997 report of 5 cases involving the scalp and hands. In 2006, Laskin and colleagues published 21 sclerotic lipomas in a study restricted to tumors of the hands and feet. Patients' ages ranged from 7 to 72 years (mean and median 39 y); there were 12 males and 9 females; the masses, which were mostly asymptomatic and solitary, ranged from 0.6 to 2.2 cm (median 1.2 cm, mean 1.3 cm) and involved fingers (N=17), hands or wrists (N=3), and toes (N=1). Microscopically, lesions were well circumscribed, of low cellularity, and consisted of cytologically bland spindle and stellate-shaped cells with a minor component of randomly dispersed adipocytes embedded in a collagenous to myxocollagenous stroma. Eight tumors were fibroma-like with dense fibrosclerotic stroma and inconspicuous blood vessels. One tumor exhibited features of spindle cell/pleomorphic lipoma, whereas another displayed a vague onion skin-like arrangement of collagen reminiscent of a sclerotic (storiform) fibroma. The mitotic activity was negligible. Nonlipogenic cells were immunoreactive for CD99 (6/6) CD34 (6/8), S100 (4/7), and smooth muscle actin (2/6). Follow-up on 8 patients (range, 1 to 20 y, median 9.5 y) revealed no recurrence in 6 and possible persistent tumor in 2 after simple excision. The slide circulated to club members was from a 35-mm tumor on the dorsum of the right hand of a male aged 75. Club members generally agreed with a diagnosis of sclerotic lipoma but opinions differed as to whether it is a specific entity or a variant of spindle cell lipoma or dendritic fibromyxolipoma. PMID:23232574

Allen, Philip W

2013-01-01

49

Sclerotic-type chronic GVHD of the skin: clinical risk factors, laboratory markers, and burden of disease  

OpenAIRE

Chronic GVHD is one of the most severe complications of allogeneic HSCT. The sclerotic skin manifestations of cGVHD (ScGVHD) result from inflammation and fibrosis of the dermis, subcutaneous tissue, or fascia, leading to significant functional disability. Risk factors and clinical markers associated with ScGVHD remain largely unexamined. By using a single-visit, cross-sectional design, we evaluated 206 patients with cGVHD at the National Institutes of Health. Most patients manifested severe (...

Martires, Kathryn J.; Baird, Kristin; Steinberg, Seth M.; Grkovic, Lana; Joe, Galen O.; Williams, Kirsten M.; Mitchell, Sandra A.; Datiles, Manuel; Hakim, Fran T.; Pavletic, Steven Z.; Cowen, Edward W.

2011-01-01

50

Aneurysmal bone cyst of the temporal bone  

International Nuclear Information System (INIS)

Aneurysmal bone cyst (ABC) of the temporal bone is rare. The nature of the underlying disorder that converted into the ABC might, however, be difficult to ascertain on imaging as well as on histopathology. The unusual CT and MRI findings in a case of ABC of the temporal bone are presented. This had transdural intracerebral spread with a large component of solid enhancing matrix but no peripheral calcific rim. The patient was an adult of 45 years with a history of headache for more than 1 year Copyright (2004) Blackwell Publishing Asia Pty Ltd

51

Bone Microstructure and Regional Distribution of Osteoblast and Osteoclast Activity in the Osteonecrotic Femoral Head  

Science.gov (United States)

Objective To detect and compare the bone microstructure and osteoblast and osteoclast activity in different regions of human osteonecrotic femoral heads. Methods Osteonecrotic femoral heads were obtained from 10 patients (6 males, 4 females; Ficat IV) undergoing total hip arthroplasty between 2011 and 2013. The samples were divided into subchondral bone, necrotic, sclerotic, and healthy regions based on micro-computed tomography (CT) images. The bone microstructure, micromechanics, and osteoblast and osteoclast activity were assessed using micro-CT, pathology, immunohistochemistry, nanoindentation, reverse transcription polymerase chain reaction (RT-PCR), tartrate-resistant acid phosphatase staining and Western blotting. Results (1) The spatial structure of the bone trabeculae differed markedly in the various regions of the osteonecrotic femoral heads. (2) The elastic modulus and hardness of the bone trabeculae in the healthy and necrotic regions did not differ significantly (P >0.05). (3) The subchondral bone and necrotic region were positive on TRAP staining, while the other regions were negative. (4) On immunohistochemical staining, RANK and RANKL staining intensities were increased significantly in the subchondral bone and necrotic region compared with the healthy region, while RUNX2 and BMP2 staining intensities were increased significantly in the sclerotic region compared with the necrotic region. (5) OPG, RANK, RANKL, RUNX2, BMP2, and BMP7 protein levels were greater in the necrotic and sclerotic region than in subchondral bone and the healthy region. Conclusion The micromechanical properties of bone trabeculae in the necrotic region did not differ significantly from the healthy region. During the progress of osteonecrosis, the bone structure changed markedly. Osteoclast activity increased in subchondral bone and the necrotic region while osteoblast activity increased in the sclerotic region. We speculate that the altered osteoblast and osteoclast activity leads to a reduction in macroscopic mechanical strength. PMID:24800992

Wang, Cheng; Wang, Xin; Xu, Xiao-long; Yuan, Xue-ling; Gou, Wen-long; Wang, Ai-yuan; Guo, Quan-yi; Peng, Jiang; Lu, Shi-bi

2014-01-01

52

Metastatic breast carcinoma to bone disguised by osteopoikilosis  

International Nuclear Information System (INIS)

A case of metastatic lobular carcinoma of the breast in conjunction with osteopoikilosis is described. Widespread diffuse sclerotic bone lesions were identified on radiographs in a patient with breast carcinoma. In addition computed tomography demonstrated discrete spherical areas of increased density throughout the skeleton manifest typically by osteopoikilosis. No systemic symptoms were evident, blood parameters were normal and the lesions did not demonstrate any increased uptake of technetium on bone scan. An iliac crest bone biopsy, however, revealed metastatic disease in addition to osteopoikilosis. Conventional radiological investigations may not delineate metastasis on a background of bone dysplasia. (orig.)

53

Association between the proportion of globally sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy patients  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Immunoglobulin A nephropathy is the most common form of glomerular nephropathy among children and young adults.Objectives: To evaluate the possible correlation between the extent of sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy (IgAN patients, we conducted an observational study, on 136 IgAN patients’ biopsies.Patients and Methods: Of the 136 patients, 94 (69.1% were male. The mean age of the patients was 37.6 ± 13.4 years. The mean of serum creatinine was 1.94±3.7 mg/dl (median=1.2mg/dl, also mean of proteinuria was 1726±1247 mg/day (median=1500 mg/day. In this study of 14.9±3.7 glomeruli in biopsies, 2.5±3.2 (median=2 were globally sclerotic.Results: In this study we found, significant positive correlation between proportion of globally sclerotic glomeruli and serum creatinine, amount of proteinuria, and also quantity of tubulointerstitial fibrosis. Also, in this study, the association of proportion of globally sclerotic glomeruli with M, E, S and T variables of Oxford classification was significantly positive.Conclusion: We propose firstly that, sclerotic glomeruli reported routinely in the pathology reports of IgA nephropathy patients and secondly we suggest further investigations to possible inclusion of other morphologic variables like proportion of sclerotic glomeruli to Oxford classification of IgAN to widen the scope of this classification.

Nasri Hamid

2012-12-01

54

The Inner Rim Structures of Protoplanetary Discs  

CERN Document Server

The inner boundary of protoplanetary discs is structured by the dramatic opacity changes at the transition from the dust-containing to a dust-free zone. This paper explores the variety and limits of inner rim structures in passively heated dusty discs. For this study, we implemented detailed sublimation physics in a fast Monte Carlo radiative transfer code. We show that the inner rim in dusty discs is not an infinitely sharp wall but a diffuse region which may be narrow or wide. Furthermore, high surface densities and large silicate grains as well as iron and corundum grains decrease the rim radius, from a 2.2AU radius for small silicates around a 47 Solar luminosity Herbig Ae star typically to 0.4AU and as close as 0.2AU. A passive disc with grain growth and a diverse dust composition must thus have a small inner rim radius. Finally, an analytical expression is presented for the rim location as a function of dust, disc and stellar properties.

Kama, M; Dominik, C

2009-01-01

55

Modulation of renin angiotensin system predominantly alters sclerotic phenotype of glomeruli in HIVAN.  

Science.gov (United States)

HIV-associated nephropathy (HIVAN) is a common complication of HIV-1 infection in patients with African ancestry in general and with APOL1 gene risk variants in particular. Although collapsing glomerulopathy is considered a hallmark of HIVAN, significant numbers of glomeruli in patients with HIVAN also display other variants of focal segmental glomerulosclerosis (FSGS). We propose that collapsed glomeruli as well as glomeruli with other variants of FSGS are manifestations of HIVAN and their prevalence depends on associated host factors. We explored the role of the renin-angiotensin system (RAS) in the manifestation of any specific glomerular phenotype in HIVAN. To evaluate the role of the RAS we have used a genetically engineered mouse model of HIVAN (Tg26) with two and four copies of angiotensinogen (Agt) gene (Tg26/Agt2 and Tg26/Agt4). In Tg26/Agt2, 1 out of 6 glomeruli exhibited sclerosed phenotype, whereas 1 out of 25 glomeruli displayed collapsed phenotype; on the other hand, in Tg26/Agt4, 1 out of 3 glomeruli exhibited sclerotic phenotype and only 1 out of 7 glomeruli showed collapsed phenotype. To inhibit the effect of RAS, Tg26/Agt2 were administered captopril, aliskiren, aliskiren plus captopril or aliskiren plus telmisartan by miniosmotic pumps for 4 weeks. In all experimental groups there was a significant reduction in percentage of sclerosed glomeruli and only minimal reduction in collapsed glomeruli compared to normal saline receiving Tg26/Agt2. These findings suggest that the manifestation of the sclerosed phenotype in HIVAN is predominantly dependent on activation of the RAS. PMID:24892944

Plagov, Andrei; Lan, Xiqian; Rai, Partab; Kumar, Dileep; Lederman, Rivka; Rehman, Shabina; Malhotra, Ashwani; Ding, Guohua; Chander, Praveen N; Singhal, Pravin C

2014-12-01

56

Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin  

OpenAIRE

Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS) and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI), the 2-step self-etch Adper SE Bond (3MESPE) and the 35% phosphoric acid (3MESPE) from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE) were applied on the bovine incisal surfaces according to the manufact...

Alexandra Patricia Mena-Serrano; Eugenio Jose Garcia; Miguel Muñoz Perez; Gislaine Cristine Martins; Rosa Helena Miranda Grande; Alessandro Dourado Loguercio; Alessandra Reis

2013-01-01

57

The multiple faces of valosin-containing protein-associated diseases: inclusion body myopathy with Paget's disease of bone, frontotemporal dementia, and amyotrophic lateral sclerosis.  

Science.gov (United States)

Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD) is a progressive, fatal genetic disorder with variable penetrance, predominantly affecting three main tissue types: muscle (IBM), bone (PDB), and brain (FTD). IBMPFD is caused by mutations in the ubiquitously expressed valosin-containing protein (VCP) gene, a member of the AAA-ATPase superfamily. The majority of individuals who develop IBM have progressive proximal muscle weakness. Muscle biopsies reveal rimmed vacuoles and inclusions that are ubiquitin- and TAR DNA binding protein-43 (TDP-43)-positive using immunohistochemistry. PDB, seen in half the individuals, is caused by overactive osteoclasts and is associated clinically with pain, elevated serum alkaline phosphatase, and X-ray findings of coarse trabeculation and sclerotic lesions. FTD diagnosed at a mean age of 55 years in a third of individuals is characterized clinically by comprehension deficits, dysnomia, dyscalculia, and social unawareness. Ubiquitin- and TDP-43-positive neuronal inclusions are also found in the brain. Genotype-phenotype correlations are difficult with marked intra-familial and inter-familial variations being seen. Varied phenotypes within families include frontotemporal dementia, amyotrophic lateral sclerosis, Parkinsonism, myotonia, cataracts, and anal incompetence, among others. Cellular and animal models indicate pathogenetic disturbances in IBMPFD tissues including altered protein degradation, autophagy pathway alterations, apoptosis, and mitochondrial dysfunction. Currently, mouse and drosophila models carrying VCP mutations provide insights into the human IBMPFD pathology and are useful as tools for preclinical studies and testing of therapeutic strategies. In this review, we will explore the pathogenesis and clinical phenotype of IBMPFD caused by VCP mutations. PMID:21892620

Nalbandian, Angèle; Donkervoort, Sandra; Dec, Eric; Badadani, Mallikarjun; Katheria, Veeral; Rana, Prachi; Nguyen, Christopher; Mukherjee, Jogeshwar; Caiozzo, Vincent; Martin, Barbara; Watts, Giles D; Vesa, Jouni; Smith, Charles; Kimonis, Virginia E

2011-11-01

58

Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis  

Directory of Open Access Journals (Sweden)

Full Text Available Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Quinck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones.A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, diagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

V Silva

2007-01-01

59

Bleomycin-induced epithelial-mesenchymal transition in sclerotic skin of mice: possible role of oxidative stress in the pathogenesis.  

Science.gov (United States)

Epithelial-mesenchymal transition (EMT) derived myofibroblasts are partly responsible for the increased collagen synthesis and deposition that occur in tissue fibrosis; however EMT occurrence in skin fibrosis and its mechanism remain unknown. The aim of this study was to investigate whether epithelial cells undergo EMT and determine the role of oxidative stress in this process. BALB/c mice were subcutaneously injected with bleomycin (BLM) or phosphate buffer saline (PBS) into the shaved back daily for 2, 3, and 4weeks. Skin collagen deposition was evaluated by histopathology and Western blotting. EMT characteristics in the skin were determined by histopathology and immunofluorescent staining for E-cadherin and vimentin, which were further evaluated by Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR). To investigate the role of oxidative stress in EMT, the antioxidant N-acetylcysteine (NAC) was intraperitoneally (100mg/kg body weight/day) injected daily for 3weeks. The epithelial suprabasal cells were detached from the basement membrane zone (BMZ) in the sclerotic skin treated with BLM. Immunofluorescent staining indicated vimentin-positive epithelial cells frequently occurring in the thickened epidermis of BLM-treated mice. Western blotting and RT-PCR showed that the expression of E-cadherin was significantly decreased but that of vimentin significantly increased in the skin treated with BLM. NAC attenuated BLM induced oxidative damage, changes in E-cadherin and vimentin expressions and collagen deposition in the sclerotic skin of mice. This study provides the first evidence that BLM induces the EMT of the epithelial cells superficial to the basement membrane zone in the skin fibrosis. Oxidative stress may contribute, at least in part, to BLM induced EMT and skin fibrosis in mice. PMID:24726524

Zhou, Cheng-Fan; Zhou, Deng-Chuan; Zhang, Jia-Xiang; Wang, Feng; Cha, Wan-Sheng; Wu, Chang-Hao; Zhu, Qi-Xing

2014-06-15

60

West Rim of Endeavour and a Farther Crater's Rim on Horizon  

Science.gov (United States)

[figure removed for brevity, see original site] In the left half of this view from the panoramic camera (Pancam) of NASA's Mars Exploration Rover Opportunity, a western portion of the rim of Endeavour Crater is visible on the horizon. In the right half, the rim of a smaller crater, farther away, appears faintly on the horizon. Opportunity's Pancam took this image on March 8, 2009, during the 1,821st Martian day, or sol, of the rover's mission on Mars. The width of the image covers approximately one degree of the horizon. The part of Endeavour's rim visible here is about 16 kilometers (10 miles) from where Opportunity was when the image was taken. The rover was at the same location as when its Pancam took images after a drive on Sol 1820. Opportunity remained at that location until a drive on Sol 1823. The more-distant rim to the right, part of Iazu Crater, is about 38 kilometers (24 miles) away. Iazu is south of Endeavour and about 7 kilometers (4 miles) in diameter.

2009-01-01

61

Dietary determinants of post-menopausal bone loss at the lumbar spine: a possible beneficial effect of iron.  

OpenAIRE

INTRODUCTION: Previous studies suggesting different effects of diet on post-menopausal bone loss may have given conflicting results because they sometimes failed to exclude confounding conditions or used imprecise methodology. DESIGN: To identify dietary determinants of bone loss from the lumbar spine after menopause in women not taking hormone replacement who developed no evidence of spondylotic or sclerotic degenerative disease, forty-three women were followed with repeated (mean = 12) meas...

Abraham, R.; Walton, J.; Russell, L.; Wolman, R.; Wardley-smith, B.; Green, Jr; Mitchell, A.; Reeve, J.

2006-01-01

62

On the Rim of 'Victoria Crater'  

Science.gov (United States)

NASA's Mars rover Opportunity reached the rim of 'Victoria Crater' in Mars' Meridiani Planum region with a 26-meter (85-foot) drive during the rover's 951st Martian day, or sol (Sept. 26, 2006). After the drive, the rover's navigation camera took the three exposures combined into this view of the crater's interior. This crater has been the mission's long-term destination for the past 21 Earth months. A half mile in the distance one can see about 20 percent of the far side of the crater framed by the rocky cliffs in the foreground to the left and right of the image. The rim of the crater is composed of alternating promontories, rocky points towering approximately 70 meters (230 feet) above the crater floor, and recessed alcoves. The bottom of the crater is covered by sand that has been shaped into ripples by the Martian wind. The position at the end of the sol 951 drive is about six meters from the lip of an alcove called 'Duck Bay.' The rover team planned a drive for sol 952 that would move a few more meters forward, plus more imaging of the near and far walls of the crater. Victoria Crater is about five times wider than 'Endurance Crater,' which Opportunity spent six months examining in 2004, and about 40 times wider than 'Eagle Crater,' where Opportunity first landed. This view is presented as a cylindrical projection with geometric seam correction.

2006-01-01

63

Aquaporin-4 expression in distal myopathy with rimmed vacuoles  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles. To date, the role of aquaporin-4 water channel in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy has not been studied. Case presentation Here, we studied the expression of aquaporin-4 in muscle fibers of a patient with distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy. Immunohistochemical and immunofluorescence analyses showed that sarcolemmal aquaporin-4 immunoreactivity was reduced in many muscle fibers of the patient. However, the intensity of aquaporin-4 staining was markedly increased at rimmed vacuoles or its surrounding areas and in some muscle fibers. The fast-twitch type 2 fibers were predominantly involved with the strong aquaporin-4-positive rimmed vacuoles and TAR-DNA-binding protein-43 aggregations. Rimmed vacuoles with strong aquaporin-4 expression seen in the distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy patient were not found in control muscles without evidence of neuromuscular disorders and the other disease-controls. Conclusions Aquaporin-4 might be crucial in determining the survival or degeneration of fast-twitch type 2 fibers in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy.

Hoshi Akihiko

2012-04-01

64

On the Rim of 'Victoria Crater' (Stereo)  

Science.gov (United States)

[figure removed for brevity, see original site] Left-eye view of a stereo pair for PIA08780 [figure removed for brevity, see original site] Right-eye view of a stereo pair for PIA08780 NASA's Mars rover Opportunity reached the rim of 'Victoria Crater' in Mars' Meridiani Planum region with a 26-meter (85-foot) drive during the rover's 951st Martian day, or sol (Sept. 26, 2006). After the drive, the rover's navigation camera took the three exposures combined into this view of the crater's interior. This crater has been the mission's long-term destination for the past 21 Earth months. A half mile in the distance one can see about 20 percent of the far side of the crater framed by the rocky cliffs in the foreground to the left and right of the image. The rim of the crater is composed of alternating promontories, rocky points towering approximately 70 meters (230 feet) above the crater floor, and recessed alcoves. The bottom of the crater is covered by sand that has been shaped into ripples by the Martian wind. The position at the end of the sol 951 drive is about six meters from the lip of an alcove called 'Duck Bay.' The rover team planned a drive for sol 952 that would move a few more meters forward, plus more imaging of the near and far walls of the crater. Victoria Crater is about five times wider than 'Endurance Crater,' which Opportunity spent six months examining in 2004, and about 40 times wider than 'Eagle Crater,' where Opportunity first landed. This view is presented as a cylindrical-perspective projection with geometric seam correction.

2006-01-01

65

Computerized phased array UT system for turbine disc rim inspection  

International Nuclear Information System (INIS)

Turbine disc rim cracking in the nuclear power plants has been a major reliability issue in recent years. This problem has led to increased interest in periodic nondestructive examination and the computerized inspection system using phased array probe called PADRIS (phased array disc rim inspection system) has been developed. It provides for rapid assessment of disk rim integrity without removing blades from the disc rim during a brief unit shutdown and in highly confined spaces. PADRIS has performed successfully during recent field trials at the nuclear power plants, and both the rapid inspection and the precise evaluation capability for the disc rim cracking was established. This paper summarizes the outline of the PADRIS system and the results of the field trial

66

Pattern of onychomycosis--a RIMS study.  

Science.gov (United States)

Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts or non-dermatophytes moulds. In this study, 500 patients suspected of having onychomycosis reffered from the out patient department (OPD), Dermatology, Regional Institute of Medical Sciences (RIMS) Hospital Imphal Manipur during the period from January 2007 to December 2008 were processed in the Department of Microbiology RIMS. Nail clippings or scrapings depending on the variety of onychomycosis were collected with sterile blades under all aseptic measures. Specimens were put up for 10% KOH mount, fungal cultures on two sets of SDA (Sabouraud's dextrose agar) incorporated with antibiotics and lactophenol cotton blue preparation (LCB) from the cultures and examined microscopically. Slide cultures were also put up if necessary. Out of 500 samples processed, a total of 444 (88.8%) were positive for the various fungi. The positive fungi were dermatophytes 258 (58.1%), non-dermatophytes 139 (31.3%), yeasts and yeast-like 17 (3.8%) and mixed fungal isolates 30 (6.7%). Of the 230 males and 270 females studied,193 (83.9%) males and 251 (92.9%) females respectively were positive for various fungi causing onychomycosis. Maximum number of suspected cases were in the age group of 21-30 years. Among the dermatophytes, Trichophyton species (spp.) 250 (50%) was the commonest isolate followed by Epidermophyton spp. 8 (1.6%). Among the non-dermatophytes, Aspergillus spp. 70 (14%) was the commonest followed by Penicillium spp. 24 (4.8%), Acremonium spp. 9 (1.8%), Fusarium spp. 8 (1.6%), Curvularia spp. 7 (1.4%), Alternaria spp. 5 (1%), Scopulariopsis spp. 4 (0.8%), Cladosporium spp. 4 (0.8%), Nigrospora spp. 2 (0.4%), Mucor spp. 1 (0.2%), Paecilomyces spp. 1 (0.2%), Pseudallescheria spp. (0.2%), Rhizopus spp. 1 (0.2%), Verticillium spp. 1 (0.2%), Exophiala jeanselmei 1 (0.2%). Among the yeast and yeast-like i.e. Candida spp. 15, Geotrichum spp. 1, Rhodotorula spp. 1 were 17 (3.8%), mixed fungal isolates 30 (6.7%), respectively. Reports were given to the patient for follow up and treatment. Health awareness and suggestions were given for prevention and further spread of onychomycosis. PMID:23785867

Pukhrambam, Pratita Devi; Devi, Kh Ranjana; Singh, Ng Brajachand

2011-06-01

67

Esclerosis inflamatoria orbitaria y síndrome de fibrosis multifocal Sclerotic inflammation of the orbit and multifocal fibrosclerosis syndrome  

Directory of Open Access Journals (Sweden)

Full Text Available Caso clínico: Mujer de 52 años que consulta en nuestro Servicio por proptosis bilateral. La aparición de sintomatología aguda digestiva durante el ingreso para el estudio de la proptosis, condujo al diagnóstico de un cuadro de fibroesclerosis multifocal, con afectación simultánea de los tejidos orbitarios, grasa mesentérica y tronco de encéfalo. Discusión: El pseudotumor esclerosante orbitario es una rara entidad clinicopatológica, cuyas características en la clínica y en las pruebas de imagen pueden ser similares a las del pseudotumor inflamatorio idiopático. El diagnóstico diferencial es importante porque ambos difieren tanto en su tratamiento como en su pronóstico.Clinical case: A fifty-two-year-old woman consulted our department because of a bilateral proptosis. The appearance of acute symptoms suggestive of a digestive disorder during her admission to hospital for the study of the proptosis, led to a diagnosis of multifocal fibrosclerosis with simultaneous affliction of orbital tissue, mesenteric fat and the brain stem. Discussion: Idiopathic Sclerotic Inflammation of the orbit is a rare pathological entity, with similar clinical and radiological characteristics to orbital pseudo-tumour. The differential diagnosis is important because both these conditions differ in treatment and prognosis.

B. Mataix

2008-04-01

68

Hallazgo de cuerpos escleróticos en un canino: sospecha de cromoblastomicosis cutánea / Sclerotic bodies found in a dog: suspected cutaneous chromoblastomycosis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Una paciente canina se presenta a consulta con prurito generalizado de curso crónico. El examen dermatológico evidencia lesiones alopécicas descamativas con hiperqueratosis en la cara interior caudal de ambos muslos. El examen microscópico directo de muestra de escamas cutáneas con KOH más tinta Qui [...] nck Parker evidencia la presencia de cuerpos escleróticos, elementos diagnósticos de cromoblastomicosis, una patología micótica muy infrecuente en Chile y previamente no reportada en cánidos. La terapia antimicótica tópica con peróxido de benzoílo consiguió la remisión clínica y micológica de las lesiones. Abstract in english A female canine patient presented a history of chronic generalized pruritus. In the dermatological examination, scaly alopecic lesions with hyperkeratosis were detected on the inner posterior face of both thighs. Microscopical examinations of skin scrapings showed the presence of sclerotic bodies, d [...] iagnostic elements of chromoblastomycosis, a mycotic infection rare in Chile and not previously described in dogs. Topical antifungal therapy with benzoyl peroxide resulted in clinical and mycological cure of lesions.

V, Silva; H, Madrid; S, Anticevic.

69

Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS) and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI), the 2-step self- [...] etch Adper SE Bond (3MESPE) and the 35% phosphoric acid (3MESPE) from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE) were applied on the bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm 2 ) and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material) was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment), according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05). Results: The duplication of the conditioning time favored only the GO adhesive (p

Alexandra Patricia, Mena-Serrano; Eugenio Jose, Garcia; Miguel Munoz, Perez; Gislaine Cristine, Martins; Rosa Helena Miranda, Grande; Alessandro Dourado, Loguercio; Alessandra, Reis.

2013-04-01

70

Influence of etching ability of one-step self-etch adhesives on bonding to sound and non-carious cervical sclerotic dentin.  

Science.gov (United States)

The purpose of this study was to evaluate influence of etching ability of one-step self-etch adhesives on bonding to non-carious cervical sclerotic lesion. Forty-eight human maxillary premolars with and without natural non-carious cervical sclerotic lesions at buccal surfaces were used in this study. Artificial wedge-shaped lesions were prepared in sound premolars. All lesions were bonded with Bond Force (BF; pH=2.3) or G-Bond Plus (GBA; pH=1.5) according to the manufacturers' instructions. After water storage for 24 hours at 37°C, bonded specimens were subjected to microtensile bond test to measure bond strength to the gingival wall in each lesion. The µTBS of BF to the natural lesion was significantly lower than that of artificial lesion (p0.05). There was no difference in µTBS to artificial lesion between these two adhesives, however in case of non-carious cervical sclerotic lesion, the µTBS of GBA was statistically higher than that of BF. PMID:22123021

Tsai, Yi-Ling; Nakajima, Masatoshi; Wang, Chen-Ying; Foxton, Richard M; Lin, Chun-Pin; Tagami, Junji

2011-11-25

71

The natural history of disappearing bone tumours and tumour-like conditions  

Energy Technology Data Exchange (ETDEWEB)

We describe 27 cases of bone tumours or tumour-like lesions where there was spontaneous regression. The follow-up period was 2.8-16.7 years (average, 7.0 years). Fourteen of these cases were no longer visible on plain radiographs. Histological diagnosis included exostosis, eosinophilic granuloma, fibrous dysplasia, fibrous cortical defect, non-ossifying fibroma, osteoid osteoma and bone island. Most cases began to reduce in adolescence or earlier, although sclerotic type lesions showed their regression in older patients. All lesions thought to be eosinophilic granuloma began to regress after periods of less than 3 months, while the duration of the other lesions showed wide variation (1-74 months). As resolution of the lesions took between 2 and 79 months (mean, 25.0 {+-} 20.3 months) we consider that the most likely mechanism was recovery of normal skeletal growth control. In exostosis with fracture, alteration of vascular supply may contribute to growth arrest, but not to subsequent remodelling stage. In inflammatory-related lesions such as eosinophilic granuloma, cessation of inflammation may be the mechanism of growth arrest, whilst temporary inflammation may stimulate osteogenic cells engaged in remodeling. In the sclerotic type, growth arrest is a less probable mechanism. Necrosis within the tumour and/or local changes in hormonal control, plus remodelling of the sclerotic area takes longer. Knowledge of the potential for spontaneous resolution may help in management of these tumour and tumour-like lesions of bone. Yanagawa, T. et al. (2001)

Yanagawa, Takashi; Watanabe, Hideomi; Shinozaki, Tetsuya; Ahmed, Adel Refaat; Shirakura, Kenji; Takagishi, Kenji

2001-11-01

72

Design analysis of Hub, Rim and Drum in Brake Assembly  

OpenAIRE

Stress analysis connected with the brake assembly of heavy vehicles is a complicated problem in view of the machine elements involved. The hub (on the rear axle), the rim (holding the wheel) and the drum (holding the brake shoe) experience severity of loads. While the vehicle is being driven the power is transmitted from the hub to the rim. When the brake is applied, the brake drum receives the braking torque and communicates it to the rim. Analysis associated with braking is actually tran...

Ramamurti V.; Sukumar T.; Mithun S.; Prabhakar N; Hudson P. V.

2013-01-01

73

Business Strategy Analysis of RIM in China's Smartphone Industry  

OpenAIRE

China, the biggest mobile phone market in the world, is crucial for the future of Research In Motion (RIM). While RIM entered China’s market in 2006, its market share is still very small in China. The launch of 3G amid the restructuring of China’s telecom industry proved crucial to the company’s development. RIM has partnered with all mobile operators in China to provide BlackBerry Enterprise Service and BlackBerry Internet Service to both business and individual users. It has gained a ...

Chen, Lei

2011-01-01

74

Diplopia following porous polyethylene orbital rim onlay implant.  

Science.gov (United States)

An 81-year-old man with ocular irritation associated with lower eyelid retraction, horizontal laxity of the lower eyelids, and hypoplastic inferior orbital rims underwent bilateral placement of porous polyethylene orbital rim onlay implants. Two weeks after surgery, he developed vertical binocular diplopia on downgaze. Examination of extraocular motility demonstrated limited infraduction OD. Surgical exploration revealed scarring in the anterior orbit between the inferior rectus pulley and the orbital implant. The orbital implant was found to lie higher than the inferior orbital rim. After surgical lysis of the scar and reduction of the vertical height of the implant, the patient's diplopia resolved. Orbital connective tissues critical to ocular motility may be abnormally superficial in orbital rim hypoplasia. Onlay grafts must be carefully placed so that they do not interfere with these tissues. PMID:12544800

Goldberg, Robert A; Li, Tina G; Demer, Joseph L

2003-01-01

75

Origin of strongly reversed rims on plagioclase in cumulates  

Science.gov (United States)

Narrow reversed rims on plagioclase are ubiquitous in troctolites and olivine gabbros of the Kiglapait intrusion and may be a common feature of all such cumulates. The rims occur at plag/plag, plag/ol, and less strongly at plag/aug grain boundaries. They are optically obvious at ?An reversed rims are only locally present at grain boundaries even for the same pair of crystals in contact; they are prominent in linear networks suggesting the last trace of intercumulus liquid. A subsolidus origin is ruled out by the absence of reactants at plag/plag and plag/ol boundaries and by the local rather than pervasive development of rims. The rims are required to grow from intercumulus liquid, in which the partition of An component between crystals and liquid increases with the trapped augite component of the liquid. Calculations from published experimental data show that ?An > 30 can easily be achieved by such a process. It is also probable that the trapped liquid is part of an An-rich boundary layer generated by solute rejection during adcumulus growth. The ability of the rims to sustain steep K/Na gradients despite a long subsolidus cooling history proves that the K sbnd Na exchange rate is vanishingly small over a geologic time scale in An-rich feldspar, suggesting that at low K content the potassium is site-bound to the tetrahedral Al/Si distribution. Reversed rims therefore provide important information on diffusion limits as well as on the late-stage solidification history of plagioclase-rich cumulates. Moreover, they demonstrate that plagioclase geothermometry cannot be divorced from effects of liquid composition and structure as monitored, for example, by augite content.

Morse, S. A.; Nolan, Kathleen M.

1984-06-01

76

Aqueous Alteration of Endeavour Crater Rim Apron Rocks  

Science.gov (United States)

Mars Exploration Rover Opportunity is exploring Noachian age rocks of the rim of 22 km diameter Endeavour crater. Overlying the pre-impact lithologies and rim breccias is a thin apron of fine-grained sediments, the Grasberg fm, forming annuli on the lower slopes of rim segments. Hesperian Burns fm sandstones overly the Grasberg fm. Grasberg rocks have major element compositions that are distinct from Burns fm sandstones, especially when comparing interior compositions exposed by the Rock Abrasion Tool. Grasberg rocks are also different from Endeavour rim breccias, but have general compositional similarities to them. Grasberg sediments are plausibly fine-grained materials derived from the impact breccias. Veins of CaSO4 transect Grasberg fm rocks demonstrating post-formation aqueous alteration. Minor/trace elements show variations consistent with mobilization by aqueous fluids. Grasberg fm rocks have low Mn and high Fe/Mn ratios compared to the other lithologies. Manganese likely was mobilized and removed from the Grasberg host rock by redox reactions. We posit that Fe2+ from acidic solutions associated with formation of the Burns sulfate-rich sandstones acted as an electron donor to reduce more oxidized Mn to Mn2+. The Fe contents of Grasberg rocks are slightly higher than in other rocks suggesting precipitation of Fe phases in Grasberg materials. Pancam spectra show that Grasberg rocks have a higher fraction of ferric oxide minerals than other Endeavour rim rocks. Solutions transported Mn2+ into the Endeavour rim materials and oxidized and/or precipitated it in them. Grasberg has higher contents of the mobile elements K, Zn, Cl, and Br compared to the rim materials. Similar enrichments of mobile elements were measured by the Spirit APXS on West Spur and around Home Plate in Gusev crater. Enhancements in these elements are attributed to interactions of hydrothermal acidic fluids with the host rocks. Interactions of fluids with the Grasberg fm postdate the genesis of the Endeavour rim phyllosilicates. The aqueous alteration history of Endeavour rim rocks is complicated by different styles of alteration that have spanned the Noachian and Hesperian. Late stage acidic aqueous alteration of Grasberg fm materials is likely penecontemporaneous with the diagenesis of the sulfate-rich sediments of Meridiani Planum.

Mittlefehldt, David W.; Ming, Douglas W.; Gellert, Ralf; Clark, Benton C.; Morris, Richard V.; Yen, Albert S.; Arvidson, Raymond E.; Crumpler, Larry S.; Farrand, William H.; Grant, John A.; Jolliff, Bradley L.; Parker, Timothy J.; Peretyazhko, Tanya

2014-01-01

77

Histologia e ultraestrutura do rim e rim cefálico do pacu / Histology and ultrastructure of kidney and cephalic kidney in Pacu  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo [...] de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de cada órgão com o uso de microscopia de luz e microscopia eletrônica de transmissão. O resultado da análise macroscópica mostrou que a localização do rim e rim cefálico são as mesmas encontradas na maioria dos teleósteos. O rim apresentou uma forma em "H", onde a região média se expandia sobre a bexiga natatória. O rim cefálico se apresentou como uma dilatação na região cranial do rim, mostrando-se bem visível. Na microscopia eletrônica de transmissão também foram observadas similaridades ultraestruturais com outros teleósteos. Observando nossos resultados concluímos que histologicamente e ultraestruturalmente, os órgãos linfóides rim e rim cefálico de Piaractus mesopotamicus são similares aos de outros teleósteos. Abstract in english The Pacu, Piaractus mesopotamicus, is a teleostei of the Characidae family, intensively cultivated in Brazil due to its rusticity, fast growth and easy adaptation. Morphological knowledge of the body systems including the lymphoid organs is necessary to improve fish production and supply subsidies f [...] or the maintenance of stocks. This study aimed to describe morphologically kidney and head kidney of Piaractus mesopotamicus, analyzing the cellular profile of each organ with the use of light microscopy and electronic transmission microscopy. The result of the macroscopic analysis showed that the localization of the kidney and head kidney is the same as found in the majority of the teleostei. The kidney presented a form in "H", where the medium region is expanded on the natatorium bladder. The head kidney presented a dilatation in the cranial region of the kidney. In the transmission electronic microscopy we found ultrastructural similarities with other teleostei fish. It can be concluded that the lymphoid organs (kidney and head kidney) of Piaractus mesopotamicus are histologically and ultra-structurally similar to the other teleostei.

Gerlane M., Costa; Ana R., Lima; Mendelson G. de, Lima; José R, Kfoury Jr.

2012-05-01

78

Deep and Bottom Water of the Weddell Sea's Western Rim  

Science.gov (United States)

Oceanographic observations from the Ice Station Weddell 1 show that the western rim of the Weddell Gyre contributes to Weddell Sea Bottom Water. A thin (<300 meters), highly oxygenated benthic layer is composed of a low-salinity type of bottom water overlying a high-salinity component. This complex layering disappears near 66^circS because of vertical mixing and further inflow from the continental margin. The bottom water flowing out of the western rim is a blend of the two types. Additionally, the data show that a narrow band of warmer Weddell Deep Water hugged the continental margin as it flowed into the western rim, providing the continental margin with the salt required for bottom-water production.

Gordon, Arnold L.; Huber, Bruce A.; Hellmer, Hartmut H.; Ffield, Amy

1993-10-01

79

Design analysis of Hub, Rim and Drum in Brake Assembly  

Directory of Open Access Journals (Sweden)

Full Text Available Stress analysis connected with the brake assembly of heavy vehicles is a complicated problem in view of the machine elements involved. The hub (on the rear axle, the rim (holding the wheel and the drum (holding the brake shoe experience severity of loads. While the vehicle is being driven the power is transmitted from the hub to the rim. When the brake is applied, the brake drum receives the braking torque and communicates it to the rim. Analysis associated with braking is actually transient since the braking torque varies with time in a short period of time whereas the one associated with driving is predominantly steady while the vehicle moves with uniform speed. None of them can be considered rotationally symmetric. Even though 3D brick element can be used for modelling all the three members, the computational effort needed to handle the problem of braking becomes extremely cumbersome. Hence a compromise solution is presented in this paper.

Ramamurti V.

2013-01-01

80

Bone metastases in stomach cancer patients: comparison of Tc-99m HDP scintigraphy and FDG PET/CT scan  

International Nuclear Information System (INIS)

To evaluate the values of FDG PET/CT and Tc-99m HDP bone scan in the detection of bone metastases in stomach cancer patients. PET/CT and bone scan images obtained within a month of each other from patients with confirmed stomach cancer, from November 2003 to November 2006, were evaluated. The number and location of the bone lesions were noted. On PET ICT, discrete focal FDG uptake distinguishable from the background cortex or marrow activity was considered a positive finding. The CT portion of the PET/CT was also reviewed for osteoblastic or osteolytic lesions. Confirmation was made by further follow up images with PET/CT, bone scan, CT, and/or MRI. Images of 203 patients were included (69 female, 134 male, average age 60.5 yrs), of which 187 cases were concluded as free from bone metastasis and 16 cases positive for bone metastases. On patient basis, the overall sensitivity, specificity, and accuracy of PET/CT were 99.5%, 87.5%, and 98.5%, and of bone scan were 96.8%, 75.0%, and 95.1 %, respectively. On lesion basis, PET/CT detected more lesions in the cervical vertebrae, while bone scan detected more lesions in the rib cage and skull. There were 5 cases where PET/CT missed lesions seen on bone scan, and the CT portion of the PET/CT demonstrated sclerotic lesions in 3 cases, mixed osteolytic and sclerotic lesion in 1 case, and equivocal finding in 1 other case. In the diagnosis of bone metastasis in stomach cancer patients, PET/CT showed higher accuracy than bone scaET/CT showed higher accuracy than bone scan. However, bone scan detected more lesions in the ribs and skull. The CT portion of the PET/CT should be carefully examined for osteoblastic metastases

81

RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse.  

Science.gov (United States)

The localization and density of voltage-gated Ca(2+) channels at active zones are essential for the amount and kinetics of transmitter release at synapses. RIM proteins are scaffolding proteins at the active zone that bind to several other presynaptic proteins, including voltage-gated Ca(2+) channel ?-subunits. The long isoforms of RIM proteins, which contain NH2-terminal Rab3- and Munc13-interacting domains, as well as a central PDZ domain and two COOH-terminal C2 domains, are encoded by two genes, Rim1 and Rim2. Here, we used the ideal accessibility of the large calyx of Held synapse for direct presynaptic electrophysiology to investigate whether the two Rim genes have redundant, or separate, functions in determining the presynaptic Ca(2+) channel density, and the size of a readily releasable vesicle pool (RRP). Quantitative PCR showed that cochlear nucleus neurons, which include calyx of Held generating neurons, express both RIM1 and RIM2. Conditional genetic inactivation of RIM2 at the calyx of Held led to a subtle reduction in presynaptic Ca(2+) current density, whereas deletion of RIM1 was ineffective. The release efficiency of brief presynaptic Ca(2+) "tail" currents and the RRP were unaffected in conditional single RIM1 and RIM2 knockout (KO) mice, whereas both parameters were strongly reduced in RIM1/2 double KO mice. Thus, despite a somewhat more decisive role for RIM2 in determining presynaptic Ca(2+) channel density, RIM1 and RIM2 can overall replace each other's presynaptic functions at a large relay synapse in the hindbrain, the calyx of Held. PMID:25343783

Han, Yunyun; Babai, Norbert; Kaeser, Pascal; Südhof, Thomas C; Schneggenburger, Ralf

2015-01-01

82

Molecular Kinematics Tracers in Bright-Rimmed Cloud SFO14  

Science.gov (United States)

The star cluster AFGL4029 and associated nebulosity IC1848 (herein referred to as bright-rimmed cloud SFO14) has been forwarded by numerous studies as an example of small-scale sequential star formation (S4F), in which star formation proceeds across a region as the result of triggering mechanisms such as Collect-and-Collapse and Radiative Driven Implosion (RDI). We would like to develop a detailed picture of the molecular dynamical interactions within SFO14 (and other regions where RDI may be responsible for star formation) in order to see if the dynamics within the cloud can be linked to the conditions in the HII region beyond the rim. We present multi-wavelength observations of the bright-rimmed cloud SFO14 in NH3(1,1) and (2,2) inversion transitions and 12CO, 13CO, and C18O (J=3->2) transitions. These observations allow determination of kinematics within the cloud (thermal and turbulent motions and outflows), cloud opacities, and kinetic temperatures. We identify two cores within SFO14: a larger primary core nearer the rim (associated with the known UCHII reigion AFGL4029-IRS1) and a weaker core approximately 2' east of the primary. These cores are apparent in both NH3 and CO maps, although positions of peak molecular emission vary by about 20". The primary core shows morphological evidence of interaction with the rim in both NH3 and CO species. These CO and NH3 observations combine with earlier observations (including 8 µm and radio emission maps) to make SFO14 one of the more convincing examples of RDI-triggered star formation. Extending these studies to a larger sample of bright-rimmed clouds is expected to verify the role of RDI as a significant contributor to the galactic IMF.

Figura, Charles C.; Morgan, L.; Moore, T.; Urquhart, J.

2011-01-01

83

Lower-Rim Substituted Calixarenes and Their Applications  

Directory of Open Access Journals (Sweden)

Full Text Available This review discusses in detail “calixarenes” since their discovery as by-products of the phenol formaldehyde bakelites till the present scenario wherein calixarene has assumed a new dimension in the field of supramolecular chemistry. Extensive literature exists for calixarenes; but herein we have tried to concentrate on the different lower-rim modified calixarenes with their potential applications. An attempt has also been made to critically evaluate the synthesis procedures for different lower-rim substituted calixarenes.

Princy Jose

2007-03-01

84

The effect of water on bimineralic reaction rims  

Science.gov (United States)

At 900°C and 1.2 GPa monticellite (CaMgSiO4) and wollastonite (CaSiO3) react to form a bimineralic reaction rim of diopside (CaMgSi2O6) and merwinite (Ca3MgSi2O8) according to the reaction: 1 monticellite + 1 wollastonite = 0.5 merwinite + 0.5 diopside Experiments were performed in a piston cylinder apparatus. Dry Al2O3, and natural, water-containing CaF2 were used as pressure media. After runs using CaF2 as pressure medium, IR-spectra of a periclase crystal, which was also loaded into the Pt-capsule, show peaks that may safely be related to OH-defects in the MgO-structure. This indicates that water, stemming from the natural CaF2 diffused into the capsule during the course of the experiment. The amount of water in the capsule increased with increasing run duration. Absence of reaction products in completely dry charges implies that presence of small amounts of water is required to promote nucleation and growth. In wet charges, time series revealed that overall rim growth is parabolic, indicating diffusion control. Textural arguments indicate that the original interface is always located in the center of the rim. This and mass balance considerations let us conclude that overall rim growth is solely controlled by MgO-diffusion. The effective bulk diffusion DMgO is calculated to 10-16.3 +/- 0.2 m2s-1. Further water uptake during the course of the experiment does not affect MgO-diffusivity. During the first stage of rim growth, the reaction products form a lamellar microstructure with alternating, pallisade shaped merwinite and diopside crystals, whereby the long axes of the grains are oriented normal to the original monticellite-wollastonite interface (lamellar type). At longer run durations, diopside and merwinite start to segregate into monomineralic layers with diopside accumulating in the center and merwinite at both sides of the reaction rim (multilayer type). After a run duration of 65 h segregation is almost complete and a triple layer rim forms showing the sequence mtc | mer | di | mer | wo. Increasing water availability significantly increases the mobility of either CaO or SiO2 or both relative to the mobility of MgO. As a consequence, the availability of water affects the structure and organization of the reaction rim. If only very small amounts are present, CaO- and SiO2-mobilities are small compared to the MgO-mobility (LCaO/LMgO CaO or SiO2 or both become more mobile relative to MgO (LCaO/LMgO > 1), and the product phases segregate into distinct monomineralic layers. Consequently, the availability of water does not only affect overall rim growth kinetics (e.g. Yund 1997), but also relative component mobilities and as a consequence the microstructure of reaction rims. Yund RA (1997), Rates of grain boundary diffusion through enstatite and forsterite reaction rims: Contrib Min and Petrol 126: 224-236.

Joachim, B.; Gardés, E.; Abart, R.; Heinrich, W.

2011-12-01

85

A radiographic investigation of third carpal bone injury in 42 racing thoroughbreds  

International Nuclear Information System (INIS)

A retrospective study of carpal radiographs from 42 racing thoroughbreds with carpal lameness was performed. Radiographs from 50 carpal examinations were available for review. The radiographic findings pertaining to the third carpal bone were described. Fractures and/or sclerosis occurred almost exclusively within the radial fossa. The occurrence of sclerosis without fracture in 20 of the 50 carpal examinations was higher than anticipated, occurring in both the right and left third carpal bone with equal frequency. The right third carpal bone was more frequently fractured and more severely affected than the left. The sclerotic changes seen in the radial fossa of the third carpal bone may be stress-induced, possibly preceding more serious changes in the joint such as cartilage damage or gross fracture. Earlier recognition of sclerosis of the third carpal bone may help prevent more serious changes from occurring

86

Factors influencing diagnostic yield of CT-guided percutaneous core needle biopsy for bone lesions  

International Nuclear Information System (INIS)

Aim: To evaluate the factors influencing diagnostic yield of computed tomography (CT)-guided percutaneous core needle biopsy (CNB) for bone lesions. Materials and methods: Between September 2005 and July 2011, 162 consecutive CT-guided CNB procedures were performed in 155 patients. The variables analysed were age, sex, lesion location, lesion type, lesion size, specimen size, biopsy needle gauge, and individual radiologist. The factors influencing diagnostic yield of CT-guided percutaneous CNB for bone lesions were determined by multivariate analysis of variables. Results: The diagnostic yield was 81.5%. Diagnostic yield was 89.9% for lytic bone lesions and 48.5% for sclerotic bone lesions (p < 0.001), and 89.2% for lesions ?3 cm and 73.4% for lesions <3 cm (p = 0.010). The significant factors influencing diagnostic yield of CT-guided percutaneous CNB for bone lesions were lesion type [p < 0.001; odds ratio (OR) for a lytic lesion was approximately 12 times higher than that for a sclerotic lesion; 95% confidence interval (CI): 4.22–34.01], and lesion size (p = 0.012; OR for a lesion size ?3 cm was about five-times higher than that for a lesion size <3 cm; 95% CI: 1.42–16.71). Conclusion: Lesion type and lesion size are determining factors in diagnostic yield. The higher diagnostic yield is correlated with lytic lesion and lesion size ?3 cm

87

Role of Rim101p in the pH response in Candida albicans  

OpenAIRE

Rim101p is a conserved fungal transcription factor that becomes activated through C-terminal cleavage under neutral to alkaline conditions. The identification and analysis of Rim101p targets in Candida albicans was the main subject of the PhD thesis. A constitutively active truncated version of Rim101p (Rim101SLp) was introduced under the control of the MET3-promotor into a rim101 null mutant to monitor Rim101-dependent transcriptional changes independently of other pH-dependent regulat...

Weyler, Michael

2007-01-01

88

Bone metastases in stomach cancer patients: comparison of Tc-99m HDP scintigraphy and FDG PET/CT scan  

Energy Technology Data Exchange (ETDEWEB)

To evaluate the values of FDG PET/CT and Tc-99m HDP bone scan in the detection of bone metastases in stomach cancer patients. PET/CT and bone scan images obtained within a month of each other from patients with confirmed stomach cancer, from November 2003 to November 2006, were evaluated. The number and location of the bone lesions were noted. On PET ICT, discrete focal FDG uptake distinguishable from the background cortex or marrow activity was considered a positive finding. The CT portion of the PET/CT was also reviewed for osteoblastic or osteolytic lesions. Confirmation was made by further follow up images with PET/CT, bone scan, CT, and/or MRI. Images of 203 patients were included (69 female, 134 male, average age 60.5 yrs), of which 187 cases were concluded as free from bone metastasis and 16 cases positive for bone metastases. On patient basis, the overall sensitivity, specificity, and accuracy of PET/CT were 99.5%, 87.5%, and 98.5%, and of bone scan were 96.8%, 75.0%, and 95.1 %, respectively. On lesion basis, PET/CT detected more lesions in the cervical vertebrae, while bone scan detected more lesions in the rib cage and skull. There were 5 cases where PET/CT missed lesions seen on bone scan, and the CT portion of the PET/CT demonstrated sclerotic lesions in 3 cases, mixed osteolytic and sclerotic lesion in 1 case, and equivocal finding in 1 other case. In the diagnosis of bone metastasis in stomach cancer patients, PET/CT showed higher accuracy than bone scan. However, bone scan detected more lesions in the ribs and skull. The CT portion of the PET/CT should be carefully examined for osteoblastic metastases.

Na, Sae Jung; Yoo, I. R.; O, J. H.; Choi, W. H.; Kim, S. H.; Chung, S. K. [The Catholic University of Korea, Seoul (Korea, Republic of)

2007-07-01

89

Evidence for the formation of a quinone methide during the oxidation of the insect cuticular sclerotizing precursor 1,2-dehydro-N-acetyldopamine.  

Science.gov (United States)

1,2-Dehydro-N-acetyldopamine (dehydro-NADA) is an important catecholamine derivative involved in the cross-linking of insect cuticular components during sclerotization. Since sclerotization is a vital process for the survival of insects, and is closely related to melanogenesis, it is of interest to unravel the chemical mechanisms participating in this process. The present paper reports on the mechanism by which dehydro-NADA is oxidatively activated to form reactive intermediate(s) as revealed by pulse radiolysis, electron spin resonance spectroscopy, high performance liquid chromatography, and ultraviolet-visible spectroscopic analysis. Pulse radiolytic one-electron oxidation of dehydro-NADA by N3. (k = 5.3 x 10(9) M-1 s-1) or Br2.- (k = 7.5 x 10(8) M-1 s-1) at pH6 resulted in the rapid generation of the corresponding semiquinone radical, lambda max 400 nm, epsilon = 20,700 M-1 cm-1. This semiquinone decayed to form a second transient intermediate, lambda max 485 nm, epsilon = 8000 M-1 cm-1, via a second order disproportionation process, k = 6.2 x 10(8) M-1 s-1. At pH 6 in the presence of azide, the first order decay of this second intermediate occurred over milliseconds; the rate decreases at higher pH. At pH 6 in the presence of bromide, the intermediate decayed much more slowly over seconds, k = 0.15 s-1. Under such conditions, the dependence of the first order decay constant upon parent dehydro-NADA concentration led to a second order rate constant of 8.5 x 10(2) M-1 s-1 for reaction of the intermediate with the parent, probably to form benzodioxan "dimers." (The term dimer is used for convenience; the products are strictly bisdehydrodimers of dehydro-NADA (see "Discussion" and Fig. 11)) Rate constants of 5.9 x 10(5), 4.5 x 10(5), 2.8 x 10(4) and 3.5 x 10(4) M-1 s-1 were also obtained for decay of the second intermediate in the presence of cysteine, cysteamine, o-phenylenediamine, and p-aminophenol, respectively. By comparison with the UV-visible spectroscopic properties of the two-electron oxidized species derived from dehydro-NADA and from 1,2-dehydro-N-acetyldopa methyl ester, it is concluded that the transient intermediate exhibiting absorbance at 485 nm is the quinone methide tautomer of the o-quinone of dehydro-NADA. Sclerotization of insect cuticle is discussed in the light of these findings. PMID:1316899

Sugumaran, M; Semensi, V; Kalyanaraman, B; Bruce, J M; Land, E J

1992-05-25

90

49 CFR 238.119 - Rim-stamped straight-plate wheels.  

Science.gov (United States)

...2010-10-01 false Rim-stamped straight-plate wheels. 238.119 Section...Requirements § 238.119 Rim-stamped straight-plate wheels. (a)(1) Except...that is equipped with a rim-stamped straight-plate wheel if a brake shoe acts...

2010-10-01

91

Pre-transplantation risk factors to develop sclerotic chronic GvHD after allogeneic HSCT: A multicenter retrospective study from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC).  

Science.gov (United States)

Sclerotic chronic GvHD (cGvHD) is one of the most severe complications after allo-hematopoietic stem cell transplantation (HSCT). Risk factors associated with this complication remain not very well defined. With the aim to define a pre-transplantation risk profile, we have conducted a French retrospective analysis in 705 consecutive patients between 2005 and 2010. Analyses to determine pre-transplantation risk factors included as variables: patient and donor age, kind of donor, HLA matching, ABO matching, sex-matching, diagnosis, stem cell source, gender, GvHD prophylaxis and antithymocyte globulin (ATG) in the conditioning regimen. The cumulative incidence of sclerotic cGvHD was 18% (95% CI, 16.6-19.6) 3 years after onset of cGvHD. In univariate analysis, we found a significantly lower number of sclerotic cGvHD form in patients transplanted from cord blood cells (P=0.0021), in patients with a one mismatched donor (P=0.041) and in patients who had received ATG in the conditioning regimen (P=0.002). In multivariate analysis, factors associated with an increased risk of sclerotic cGvHD were young patient age, multiple myeloma and PBSC as the stem cell source. ATG in conditioning regimen and cord blood unit as the stem cell source were associated with a lower risk. PMID:25365068

Detrait, M Y; Morisset, S; Peffault de Latour, R; Yakoub-Agha, I; Crocchiolo, R; Tabrizi, R; Bay, J-O; Chevalier, P; Barraco, F; Raus, N; Vigouroux, S; Magro, L; Mohty, M; Milpied, N; Blaise, D; Socié, G; Michallet, M

2015-02-01

92

Effects of tricyclazole (5-methyl-1,2,4-triazol[3,4] benzothiazole), a specific DHN-melanin inhibitor, on the morphology of Fonsecaea pedrosoi conidia and sclerotic cells.  

Science.gov (United States)

The influence of tricyclazole (5-methyl-1,2,4-triazol[3,4]benzothiazole), a specific DHN-melanin inhibitor, on the cell walls and intracellular structures of Fonsecaea pedrosoi conidia and sclerotic cells was analyzed by transmission electron microscopy (TEM), deep-etching, and field emission scanning electron microscopy. The treatment of the fungus with 16 microg mL(-1) of tricyclazole (TC) did not significantly affect fungal viability, but electron microscopy observations showed several important morphological differences between TC-treated and non-TC treated cells. Control sclerotic cells presented patched granules, with an average diameter of 47 nm, on the cell surface, which were absent in TC-treated cells. Also, TC-treated sclerotic cells showed an undulated relief. TC treatment leads to an accumulation of electron lucent vacuoles in the fungal cytoplasm of both conidia and sclerotic cells, and treated conidia observed by deep etching showed a relevant thickening of the fungal cell wall. Together, these observations support the previous data of our group that F. pedrosoi synthesizes melanin in intracellular organelles. In addition, we suggest that melanin is not only an extracellular constituent but could also be dispersing all over the cell walls and could have an effective role in cross-linking different cell wall compounds that help maintain the regular shape of the cell wall. PMID:16850396

Franzen, Anderson J; Cunha, Marcel M L; Batista, Evander J O; Seabra, Sergio H; De Souza, Wanderley; Rozental, Sonia

2006-09-01

93

View of 'Bottomless Bay' on Rim of 'Victoria'  

Science.gov (United States)

As part of its investigation of 'Victoria Crater,' NASA's Mars Exploration Rover Opportunity examined a section of the scalloped rim called 'Bottomless Bay' (or 'Bahia sin Fondo'). This view shows the northeastern side of Bottomless Bay as seen from the southwest. The exposures combined into this mosaic were taken by the rover's panoramic camera through a 750-nanometer filter during the 1,019th Martian day, or sol, of Opportunity's Mars-surface mission (Dec. 5, 2006).

2006-01-01

94

Donor corneoscleral rim contamination by gentamicin-resistant organisms  

OpenAIRE

Gentamicin is the most widely used antibiotic in the decontamination of donor cornea for penetrating keratoplasty. However, the incidence of resistance to gentamicin is on the rise. Bacterial isolates from 178 donor corneal rims were studied for gentamicin sensitivity. The overall rate of gentamicin resistance was 63.4%. At 86.2% the Pseudomonas. species had the highest rate of resistance, followed by Streptococci at 84.6%. The high rate of gentamicin resistance encounter...

Gopinathan Usha; Agrawal Vinay; Sharma Savitri; Rao Gullapalli

1994-01-01

95

Lower-Rim Substituted Calixarenes and Their Applications  

OpenAIRE

This review discusses in detail “calixarenes” since their discovery as by-products of the phenol formaldehyde bakelites till the present scenario wherein calixarene has assumed a new dimension in the field of supramolecular chemistry. Extensive literature exists for calixarenes; but herein we have tried to concentrate on the different lower-rim modified calixarenes with their potential applications. An attempt has also been made to critically evaluate the synthesis pro...

Princy Jose; Shobana Menon

2007-01-01

96

Ultrasonic Resonance Spectroscopy of Composite Rims for Flywheel Rotors  

Science.gov (United States)

Flywheel energy storage devices comprising multilayered composite rotor systems are being studied extensively for utilization in the International Space Station. These composite material systems were investigated with a recently developed ultrasonic resonance spectroscopy technique. The ultrasonic system employs a continuous swept-sine waveform and performs a fast Fourier transform (FFT) on the frequency response spectrum. In addition, the system is capable of equalizing the amount of energy at each frequency. Equalization of the frequency spectrum, along with interpretation of the second FFT, aids in the evaluation of the fundamental frequency. The frequency responses from multilayered material samples, with and without known defects, were analyzed to assess the capabilities and limitations of this nondestructive evaluation technique for material characterization and defect detection. Amplitude and frequency changes were studied from ultrasonic responses of thick composite rings and a multiring composite rim. A composite ring varying in thickness was evaluated to investigate the full thickness resonance. The frequency response characteristics from naturally occurring voids in a composite ring were investigated. Ultrasonic responses were compared from regions with and without machined voids in a composite ring and a multiring composite rim. Finally, ultrasonic responses from the multiring composite rim were compared before and after proof spin testing to 63,000 rpm.

Harmon, Laura M.; Baaklini, George Y.

2002-01-01

97

A SCUBA survey of bright-rimmed clouds  

Science.gov (United States)

Context: Bright-rimmed clouds (BRCs) are potential examples of triggered star formation regions, in which photoionisation driven shocks caused by the expansion of HII regions induce protostellar collapse within the clouds. Aims: The main purpose of the paper is to establish the level of star formation occuring within a known set of BRCs. A secondary aim is to determine the extent, if any, to which this star formation has been promulgated by the process of photoionisation triggering. Methods: A primary set of observations is presented obtained with submillimeter SCUBA observations and archival data from near-IR and mid- to far-IR have been explored for relevant observations and incorporated where appropriate. Results: SCUBA observations show a total of 42 dense cores within the heads of 44 observed BRCs drawn from a catalogue of IRAS sources embedded within HII regions, supportive of the scenario proposed by RDI models. The physical properties of these cores indicate star formation across the majority of our sample. This star formation appears to be predominately in the regime of intermediate to high mass and may indicate the formation of clusters. IR observations indicate the association of early star forming sources with our sample. A fundamental difference appears to exist between different morphological types of BRC, which may indicate a different evolutionary pathway toward star formation in the different types of BRC. Conclusions: Bright-rimmed clouds are found to harbour star formation in its early stages. Different evolutionary scenarios are found to exist for different morphological types of BRC. The morphology of a BRC is described as type “A”, moderately curved rims, type “B”, tightly curved rims, and “C”, cometary rims. “B” and “C” morphological types show a clear link between their associated star formation and the strength of the ionisation field within which they are embedded. An analysis of the mass function of potentially induced star-forming regions indicate that radiatively-driven implosion of molecular clouds may contribute significantly toward the intermediate to high-mass stellar mass function. Appendix is only available in electronic form at http://www.aanda.org

Morgan, L. K.; Thompson, M. A.; Urquhart, J. S.; White, G. J.

2008-01-01

98

Electric pulse treatment of rim wheel metal after operation  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction. Load increase on the wheel pair ax requires the use of railway wheels with the advanced complex of properties. Except strength properties, the properties of metal resistance to defect nucleation on the wheel thread are of high importance. The above mentioned properties increase is possible by using different technological decisions: alloying and heat strengthening. Purpose. The purpose is an attempt to estimate the softening degree of the wheel thread metal using the electric pulse treatment. Methodology. Electric pulse treatment (ET was carried out on the special plant in the conditions of JSC DS (Nikolayev city. As the property of metal strength the Vickers hardness number is used. The microstructure research was carried out using the light microscope. The material for research is the carbon steel of the rim fragment of railway wheel ?181732, withdrawn after operation, containing 0,55%?, 0,74%Mn, 0,33%Si, 0,009%P, 0,01%S, 0,06% Ni, 0,1%Cr, 0,08%Cu. Findings. Exposing the rim fragment to electric pulse treatment (ET, the qualitative changes of internal structure of the wheel rim metal corresponded to the experimentally observed geometrical dimensions change of the specimen, depending on the cycles number. As a result of the treatment the reduction of cold strained metal hardness is observed. It was found out 20 % softening on the wheel thread for the ? rim area the, for the ?? rim area the 8% softening and for the ??? 11% softening in relation to the initial state. Originality. As a result of electric pulse treatment, the change of the specimen geometrical dimensions is observed. Depending on the number of cycles it causes softening effect. It is proved that the observed softening value during ET is qualitatively connected with the cold strain level on the rail wheel thread. Practical value. As a result of metal cold work on the wheel thread its resistance to the defect nucleation is being reduced. The resulted data can be used during elaboration of measures to increase the operational safety of railway transport The technology development of the strain hardening embrittling influence reduce is an important scientific direction in further researches.

L.I.Vakulenko

2013-02-01

99

Hydrogeology associated to faulting of the Chicxulub Impact Crater rim  

Science.gov (United States)

The only surface expression of the Chicxulub Impact Crater is a Ring of Cenotes (sinkholes) whose density varies from several cenotes per kilometer, to several kilometers between each cenote. This ring has a radius of approximately 90 km and it is centered at Chicxulub Puerto. It is not known today whether the Ring of Cenotes is the surface expression of the transient cavity as some authors have suggested, or whether it is the outer rim of the impact structure. The center of the ring is approximately coincident with the center of the Chicxulub Impact Crater. Reactivation of K/T rim faults had been associated to the formation of the ring of cenotes. However, none of these models project such faults to the Tertiary sedimentary sequence; therefore we can only infer that the cenotes are associated to these faults. Other hypotheses include "post impact subsidence induced by slumping and viscous relaxation in the rim" and "slumping in the rim of the buried crater, differential thickness in the rocks overlying the crater, or solution collapse within porous impact deposits", others suggest duration of subaerial exposure and weathering as a principal reason both for difference in permeability and cenote density inside and outside the Ring. This is consistent with the evolution of surface features reported. While sedimentation occurred in the basin outlined by the Ring, erosion and karst weathering were taking place outside the Ring. The karst features are associated with gravity gradients, which have been interpreted as corresponding to peripheral faults of the buried crater. We conducted geoelectric tomography perpendicular to the ring of cenotes, where we mapped the karstic features in the area and we interpret the high permeability in this area, to be associated to the faults generated by the differential compaction of the sedimentary sequence within the crater. This fault system generates a secondary porosity with high permeability that allows the circulation of water, which, in turn, will dissolve the carbonates of the roof and hanging walls of the faults. Another group of cenotes, that is not related to the ring of cenotes, is the alignment of >100 km long chains of elongated solution depressions locally known as sabanas along the Holbox fracture zone-Xel-Ha zone; these alignments support the hypothesis of generation of karst features associated to weakness zones in major fractures zones, such as Holbox fracture zone-Xel-Ha zone and the Chicxulub crater rim.

Rebolledo-Vieyra, M.; Hernandez-Terrones, L.; Almazan-Becerril, A.; Valadez-Cruz, F.

2011-12-01

100

Chemical and mechanical feedback during reaction rim growth  

Science.gov (United States)

The system MgO-SiO2, including the mineral reaction quadruple periclase-forsterite-enstatite-quartz, has for several years become a favored target for laboratory and thought experiments on reaction rim growth, on the possible grain-scale pressure variability evolving during metamorphic reactions, and on the role of the local reaction volume in guiding kinetic pathways. Both isotope tracer and microstructure analyses indicate that the relative opposite fluxes of MgO and SiO2 components obey the limitations in space dictated by the stoichiometry of the local partial reactions. However, if the component's mobility is high, this implies local competition between mineral growth and the yield strength of the surrounding matrix, thus local pressure variation. Experimentally this is validated by the significant differences in Opx rim thickness, either forming around Ol in Qtz matrix, or around Qtz in Ol matrix, in one and the same experiment. Tantamount observations have been experimentally made in the CaO-SiO2 and CaO-MgO-SiO2 systems. In all these laboratory experiments, the presence of traces of water has been identified as a leading variable controlling the mobility of chemical species. Trace amounts of water follow local pressure gradients and speed up reaction rates where local volume change is negative. New results indicate that at least in coarse grained rocks, total water contents in the 10 ppm range might increase chemical fluxes along grain boundaries by orders of magnitude. The majority of metamorphic rocks in the Earth's crust is dominated by aluminuous silicates and quartz. Reaction rims in aluminosilicate lithologies have been studied in samples of high-pressure felsic granulites from the Bohemian Massif (Variscan belt of Central Europe). They show well developed plagioclase reaction rims around kyanite grains in two microstructural settings. Plagioclase rims around kyanite inclusions within large perthites have a radial thickness of up to 50 ?m, whereas the radial thickness of plagioclase rims around kyanites in the polycrystalline matrix is significantly larger, up to 200 ?m. The difference in the rim thickness for the two microstructural settings is ascribed to the complex interplay of the efficiency of chemical mass transfer and the mechanical response of the surrounding matrix next to the reaction site. Our data based on numerical modelling show that the microstructure may be generated and maintained on the geological time scale as a result of the mechanical feedback induced by the local reactions taking place in restricted space. In general, the observations from experimental and natural systems indicate that assumed equilibria in metamorphic rocks must be generally considered as local equilibria. This includes not only the chemical composition of metamorphic minerals, but also the strength of the surrounding matrix in which they form.

Milke, R.; Tajcmanova, L.

2012-12-01

101

Thermally-induced amphibole reaction rim development: EBSD insights into microlite orientation  

Science.gov (United States)

Amphibole is an important mineral present in many calc-alkaline volcanic deposits. A hydrous phase, volcanic amphibole is only stable at pressures greater than 100 MPa (approx. 4 km), temperature less than ~860-870 oC, and in melts containing at least 4 wt % H2O. When removed from their thermal and barometric stability field, amphiboles decompose to form aggregate rims of anhydrous minerals. The thickness, texture, and mineralogy of these rims are thought to be reflective of the process driving amphibole disequilibrium (e.g. heating, decompression, etc). However, significant overlap in rim thicknesses and microlite textures means that distinguishing between processes it not simple. This study employed backscatter diffraction (EBSD) to examine both experimental heating-indced amphibole reaction rims and natural amphibole reaction rim from Augustine Volcano. We collected crystal orientation maps of amphibole reaction rims to investigate if different types of disequilibrium produce different patterns of microlite orientation. We identified two types of reaction rim: Type 1- reaction rim microlites are generally oriented at random and share little or no systematic relationship with the crystallographic orientation of the host amphibole, and; Type 2- reaction rim microlites exhibit a topotactic relationship with the host amphibole (they share the same crystallographic orientation). Experimentally produced heating reaction rims are without exception Type 2. However the natural reaction rims are evenly distributed between Types 1 and 2. Further experimental data on decompression induced reaction rim formation is needed to investigate if Type 1 reaction rims resemble the breakdown of amphibole due to decompression. If so, reaction rim microlite orientation could provide a clear method for distinguishing between heating and decompression processes in amphibole bearing magmas.

De Angelis, Sarah; Lavallée, Yan; Larsen, Jessica; Mariani, Elisabetta

2014-05-01

102

The natural history of disappearing bone tumours and tumour-like conditions  

International Nuclear Information System (INIS)

We describe 27 cases of bone tumours or tumour-like lesions where there was spontaneous regression. The follow-up period was 2.8-16.7 years (average, 7.0 years). Fourteen of these cases were no longer visible on plain radiographs. Histological diagnosis included exostosis, eosinophilic granuloma, fibrous dysplasia, fibrous cortical defect, non-ossifying fibroma, osteoid osteoma and bone island. Most cases began to reduce in adolescence or earlier, although sclerotic type lesions showed their regression in older patients. All lesions thought to be eosinophilic granuloma began to regress after periods of less than 3 months, while the duration of the other lesions showed wide variation (1-74 months). As resolution of the lesions took between 2 and 79 months (mean, 25.0 ± 20.3 months) we consider that the most likely mechanism was recovery of normal skeletal growth control. In exostosis with fracture, alteration of vascular supply may contribute to growth arrest, but not to subsequent remodelling stage. In inflammatory-related lesions such as eosinophilic granuloma, cessation of inflammation may be the mechanism of growth arrest, whilst temporary inflammation may stimulate osteogenic cells engaged in remodeling. In the sclerotic type, growth arrest is a less probable mechanism. Necrosis within the tumour and/or local changes in hormonal control, plus remodelling of the sclerotic area takes longer. Knowledge of the potential for spontaneous resolution may help in managemeontaneous resolution may help in management of these tumour and tumour-like lesions of bone. Yanagawa, T. et al. (2001)

103

Bone Diseases  

Science.gov (United States)

Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly ... childhood and your teens, your body adds new bone faster than it removes old bone. After about ...

104

Bone Cancer  

Science.gov (United States)

Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another ... more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and ...

105

A prospective analysis of CT density measurements of bone metastases after treatment with zoledronic acid  

International Nuclear Information System (INIS)

The objective was to prospectively determine CT density changes in bone metastases, before and after intravenous zoledronic acid for a maximum period of 12 months. Twenty-three consecutive patients presented with bone metastases and underwent therapy with zoledronic acid from December 2004. All patients underwent CT of the chest, abdomen, and pelvis. Bone density, measured in Hounsfield units (HU), was determined by segmenting lesions in the same anatomical area of the metastasis sites on the axial images of the sequential series of CT examinations. The effects of zoledronic acid were evaluated by calculating absolute and relative increases in bone density. The patients presented with multiple metastases in 65% of the cases. When compared with the baseline, all groups demonstrated a significant increase in bone density, which significantly (p < 0.01) correlated with the number of zoledronic acid administrations. There was increased bone density of at least 100% in 57%, and an increase of at least 50% in 87% of the patients. This increase was significant in both lytic and sclerotic metastases after 3 months of therapy. No significant bone density difference was found in normal-appearing bone. Bone density measured by CT increases at metastatic sites after zoledronic acid treatment, regardless of the type of metastasis, in contrast to apparently normal bone. (orig.)

106

A prospective analysis of CT density measurements of bone metastases after treatment with zoledronic acid  

Energy Technology Data Exchange (ETDEWEB)

The objective was to prospectively determine CT density changes in bone metastases, before and after intravenous zoledronic acid for a maximum period of 12 months. Twenty-three consecutive patients presented with bone metastases and underwent therapy with zoledronic acid from December 2004. All patients underwent CT of the chest, abdomen, and pelvis. Bone density, measured in Hounsfield units (HU), was determined by segmenting lesions in the same anatomical area of the metastasis sites on the axial images of the sequential series of CT examinations. The effects of zoledronic acid were evaluated by calculating absolute and relative increases in bone density. The patients presented with multiple metastases in 65% of the cases. When compared with the baseline, all groups demonstrated a significant increase in bone density, which significantly (p < 0.01) correlated with the number of zoledronic acid administrations. There was increased bone density of at least 100% in 57%, and an increase of at least 50% in 87% of the patients. This increase was significant in both lytic and sclerotic metastases after 3 months of therapy. No significant bone density difference was found in normal-appearing bone. Bone density measured by CT increases at metastatic sites after zoledronic acid treatment, regardless of the type of metastasis, in contrast to apparently normal bone. (orig.)

Quattrocchi, Carlo C.; Dell' Aia, Paola; Piciucchi, Sara; Grasso, Rosario F.; Zobel, Bruno B. [Centro Interdisciplinare per la Ricerca Bio-Medica, Department of Radiology, Rome (Italy); Santini, Daniele; Vincenzi, Bruno; Tonini, Giuseppe [University Campus Bio-Medico di Roma, Department of Oncology, Rome (Italy); Leoncini, Emanuele [Statistica Sanitaria, University La Sapienza, Rome (Italy)

2007-12-15

107

[Computed tomography of the temporal bone in diagnosis of chronic exudative otitis media].  

Science.gov (United States)

Computed tomography (CT) of the temporal bone was made in 37 patients aged 2 to 55 years with chronic exudative otitis media (CEOM). In 21 of them the pathology was bilateral. The analysis of 58 CT images has identified CT signs of chronic exudative otitis media. They include partial (17 temporary bones) or complete (38 temporal bones) block of the bone opening of the auditory tube, pneumatic defects of the tympanic cavity (58 temporal bones), pneumatic defects of the mastoid process and antrum (47 temporal bones), pathologic retraction of the tympanic membrane. The examination of the temporal bone detected both CT-signs of CEOM and other causes of hearing disorders in 14 patients (26 temporal bones) with CEOM symptoms and inadequately high hypoacusis. Among these causes were malformation of the auditory ossicula (n=5), malformation of the labynthine window (n=2), malformation of the middle and internal ear (n=4), a wide aqueduct of the vestibule, labyrinthine anomaly of Mondini's type (n=1), cochlear hypoplasia (n=4), stenosis of the internal acoustic meatuses (n=2). Sclerotic fibrous dysplasia was suggested in 2 temporal bones (by CT data). CT was repeated after surgical treatment of 10 patients (14 temporal bones) and visual assessment of tympanostomy results was made. PMID:15700004

Zelikovich, E I

2005-01-01

108

Radiography, Bone Scan, and F-18 FDG PET/CT Imaging Findings in a Patient with Paget's Disease  

Energy Technology Data Exchange (ETDEWEB)

Background A 52-year-old female patient sought evaluation at our hospital for an incidental abnormal finding on an abdominal radiograph. The initial radiograph showed irregular sclerotic changes involving the right pelvic bone. At the same time, bone scintigraphy showed intense hot uptake in the right iliac and pubic bones. CT images showed characteristic thickening of the pelvic brim, suggesting the mixed phase of Paget's disease. The level of alkaline phosphatase (ALP) was 266 IU/I. {sup 18}F-FDG PET/CT images also showed diffusely increased {sup 18}F-FDG uptake in the right pelvic bone. However, the findings of {sup 18}F-FDG PET/CT were less notable than those of bone scintigraphy. We report the imaging findings of a patient with Paget's disease evaluated by radiography, bone scintigraphy, and {sup 18}F-FDG PET/CT.

Park, Eun Tae; Kim, Sung Eun [Korea University Guro Hospital, Seoul (Korea, Republic of)

2010-04-15

109

Amphibole reaction rim textures and mineralogy from the 2006 eruption of Augustine Volcano, Alaska: Nature vs. experiment  

Science.gov (United States)

Augustine Volcano forms a small island located in Alaska's Cook Inlet, approximately 180 miles southwest of Anchorage. The 2006 eruption began January 11, 2006, and evolved from an initial phase of explosive activity, through continuous and effusive phases, ending approximately mid-March 2006. We present data on the textural and mineralogical make-up of amphibole reaction rims from 2006 andesites from Augustine. Naturally formed reaction rims are compared to rims formed through decompression and heating experiments. Amphiboles make up less than 1 modal % of most samples. However, variations in composition and texture help to explain pre-and syn-eruptive magma histories. The Augustine 2006 amphiboles contain a mixture of rimmed and unrimmed grains. In order of decreasing abundance (by tally), the dominant phases in reaction rims are orthopyroxene, oxides, plagioclase, and clinopyroxene. Most amphibole reaction rims are between 1- 40 microns in thickness. Thicker rims (> 40 microns) were primarily erupted in the later effusive phase of the eruption. In general, the thickest reactions rims (> 60 microns average thickness) contain coarser individual reaction rim grains (with feret diameters of 15-50 microns). Reaction rims with average thickness of less than 60 microns tend to contain finer reaction rim grains (with feret diameters of 10 microns or less). Some reactions rims show a coarsening of rim grains across the rim, from the amphibole boundary to the glass boundary. Preliminary results show no systematic changes in the aspect ratios of reaction rim grains, either across the rim, or between the different rims. Some rims show a decrease in the An content of plagioclase across the rim, from the amphibole boundary to the glass boundary. Reaction rim textures and mineralogy are complex and suggest that multiple forcing factors (including heating and decompression) were responsible for their formation. This study will compare these natural reaction rims to those formed in experiments.

Henton, S.; Larsen, J. F.; Coombs, M. L.

2011-12-01

110

49 CFR 571.120 - Tire selection and rims and motor home/recreation vehicle trailer load carrying capacity...  

Science.gov (United States)

...2010-10-01 2010-10-01 false Tire selection and rims and motor home...Vehicle Safety Standards § 571.120 Tire selection and rims and motor home... S1. Scope. This standard specifies tire and rim selection requirements, rim...

2010-10-01

111

View of 'Bottomless Bay' on Rim of 'Victoria' (Altered Contrast)  

Science.gov (United States)

As part of its investigation of 'Victoria Crater,' NASA's Mars Exploration Rover Opportunity examined a section of the scalloped rim called 'Bottomless Bay' (or 'Bahia sin Fondo'). This view shows the northeastern side of Bottomless Bay as seen from the southwest. The exposures combined into this mosaic were taken by the rover's panoramic camera through a 750-nanometer filter during the 1,019th Martian day, or sol, of Opportunity's Mars-surface mission (Dec. 5, 2006). Contrast has been altered to improve the visibility of details in shadowed areas.

2006-01-01

112

Prostate cancer with lytic bone metastases: 18F-fluorodeoxyglucose positron emission tomography-computed tomography for diagnosis and monitoring response to medical castration therapy  

International Nuclear Information System (INIS)

Lytic bone metastases are rare in prostate cancer. We here present 18 fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography computed tomography (PET-CT) images of a 67-year-old male patient with lytic metastases from prostate cancer. Repeat 18F-FDG PET-CT done 6 months later showed response to medical castration therapy. While the role of 18F-FDG PET-CT for sclerotic bone metastases in prostate cancer remains controversial, it appears to be useful for detection and response assessment of lytic prostate cancer metastases. (author)

113

The importance of rim removal in deep lateral orbital wall decompression  

Directory of Open Access Journals (Sweden)

Full Text Available Hirohiko Kakizaki1, Yasuhiro Takahashi1, Akihiro Ichinose2, Masayoshi Iwaki1, Dinesh Selva3, Igal Leibovitch41Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi, Japan; 2Department of Plastic Surgery, Kobe University, Kobe, Hyogo, Japan; 3South Australian Institute of Ophthalmology and Discipline of Ophthalmology and Visual Sciences, University of Adelaide, South Australia, Australia; 4Division of Oculoplastic and Orbital Surgery, Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, IsraelPurpose: To evaluate the surgical outcome of deep lateral orbital decompression with or without rim removal.Design: Retrospective case series.Methods: Thirty-two patients (47 orbits with Graves’ orbitopathy who underwent simple deep lateral decompression or balanced lateral plus medial decompression. Of the 14 patients (24 orbits who underwent simple deep lateral decompression, 8 (13 orbits had temporary rim removal and in 6 (11 orbits the rim was left intact. Of the 18 patients (23 orbits who underwent a balanced decompression, 7 (9 orbits had temporary rim removal and in 11 (14 orbits the rim was left intact. The amount of postoperative reduction in proptosis was compared among these four groups.Results: The average reduction in proptosis in the simple deep lateral decompression group was 5.73 mm (range: 4.0–8.0 mm in the rim removal group and 4.09 mm (range: 2.5–6.0 mm in the intact rim group (P = 0.005. The average reduction in proptosis in the balanced decompression group was 6.39 mm (range: 5.0–8.5 mm in the rim removal group and 5.07 mm (range: 3.0–8.0 mm in the intact rim group (P = 0.039. There was no statistically significant difference in proptosis reduction between the simple deep lateral decompression with rim removal group and the balanced decompression with an intact rim group (P = 0.220.Conclusion: The rim removal approach allows a more effective decompression than the intact rim approach. Simple deep lateral decompression with rim removal approach has a similar effect to balanced decompression through an intact rim.Keywords: deep lateral decompression, balanced decompression, rim removal, intact rim, Graves’ orbitopathy, proptosis

Kakizaki H

2011-06-01

114

Bone Markers  

Science.gov (United States)

... imaging) and/or when a person has a history of unexpected bone fracture. One or more bone marker tests may ... two that evaluate bone formation. The choice of bone markers will depend on many factors, including your medical history, signs and symptoms , and physical examination, and these ...

115

Whale bones  

Science.gov (United States)

Vertebrates, or animals that have a skeletal structure for body support, leave bones behind after their death. These bones can be placed together to recreate the skeletal frame of that animal. Bones can be examined to determine what animal the bones came from.

N/A N/A (Go Card USA; )

2007-12-21

116

Analysis of the energy capacity of rim-spoke composite flywheels  

International Nuclear Information System (INIS)

The rim-spoke flywheel consisting of a rim, connected to the hub by spokes encompassing the rim periphery, is one of the most promising types of energy accumulators. For the rational design of rim-spoke flywheels, the authors investigate the dependence of their mass energy capacity and their volume energy capacity; the limit speed on the geometric parameters of the flywheel and the properties of the composites used in making the rim and the spokes are also examined. It is shown through various programs, worked out for analyzing the energy capacity of rim-spoke flywheels, that they can substantially facilitate the designing of such flywheels according to specified requirements that their operational characteristics have to meet

117

Externally Influenced Evolution in Bright-Rimmed Cloud SFO 14  

Science.gov (United States)

Bright-Rimmed Clouds (BRCs) are situated on the periphery of HII regions and are suspected sites of triggered star formation via the the mechanism of Radiative Driven Implosion (RDI). The focus of this study is to investigate the conditions within one BRC and determine the effects of the ionizing radiation on star formation and cloud evolution. We present multi-wavelength observations of the BRC SFO14 (IC 1848A) in NH3(1,1) and (2,2), CCS(J=2-1), and CO(J=3-2). These observations are complemented with archival Spitzer data. The NH3(1,1) emission maps two cores within SFO14, the larger of which is coincident with star forming region AFGL 4029 and a SCUBA submillimetre core previously reported by Morgan et al. (accepted). This extended emission around the core shows strong evidence of erosion by ionizing radiation (including elongation radially away from ionizing source BD +59 578). The velocity distribution of the elongation suggests that this core is located to the foreground of BD +59 578. NH3 inversion line measurements indicate rotation temperatures between 15K and 30K for the cloud, with higher rotation temperatures at the windward edge of the primary core nearest the cloud rim.

Figura, Charles C.; Morgan, L.; Urquhart, J.

2007-12-01

118

On the Rim of 'Victoria Crater' (Vertical Projection)  

Science.gov (United States)

NASA's Mars rover Opportunity reached the rim of 'Victoria Crater' in Mars' Meridiani Planum region with a 26-meter (85-foot) drive during the rover's 951st Martian day, or sol (Sept. 26, 2006). After the drive, the rover's navigation camera took the three exposures combined into this view of the crater's interior. This crater has been the mission's long-term destination for the past 21 Earth months. A half mile in the distance one can see about 20 percent of the far side of the crater framed by the rocky cliffs in the foreground to the left and right of the image. The rim of the crater is composed of alternating promontories, rocky points towering approximately 70 meters (230 feet) above the crater floor, and recessed alcoves. The bottom of the crater is covered by sand that has been shaped into ripples by the Martian wind. The position at the end of the sol 951 drive is about six meters from the lip of an alcove called 'Duck Bay.' The rover team planned a drive for sol 952 that would move a few more meters forward, plus more imaging of the near and far walls of the crater. Victoria Crater is about five times wider than 'Endurance Crater,' which Opportunity spent six months examining in 2004, and about 40 times wider than 'Eagle Crater,' where Opportunity first landed. This view is presented as a vertical projection with geometric seam correction.

2006-01-01

119

On the Rim of 'Victoria Crater' (Polar Projection)  

Science.gov (United States)

NASA's Mars rover Opportunity reached the rim of 'Victoria Crater' in Mars' Meridiani Planum region with a 26-meter (85-foot) drive during the rover's 951st Martian day, or sol (Sept. 26, 2006). After the drive, the rover's navigation camera took the three exposures combined into this view of the crater's interior. This crater has been the mission's long-term destination for the past 21 Earth months. A half mile in the distance one can see about 20 percent of the far side of the crater framed by the rocky cliffs in the foreground to the left and right of the image. The rim of the crater is composed of alternating promontories, rocky points towering approximately 70 meters (230 feet) above the crater floor, and recessed alcoves. The bottom of the crater is covered by sand that has been shaped into ripples by the Martian wind. The position at the end of the sol 951 drive is about six meters from the lip of an alcove called 'Duck Bay.' The rover team planned a drive for sol 952 that would move a few more meters forward, plus more imaging of the near and far walls of the crater. Victoria Crater is about five times wider than 'Endurance Crater,' which Opportunity spent six months examining in 2004, and about 40 times wider than 'Eagle Crater,' where Opportunity first landed. This view is presented as a polar projection with geometric seam correction.

2006-01-01

120

Optimization of Hydride Rim Formation in Unirradiated Zr 4 Cladding  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this work is to build on the results reported in the M2 milestone M2FT 13PN0805051, document number FCRD-USED-2013-000151 (Hanson, 2013). In that work, it was demonstrated that unirradiated samples of zircaloy-4 cladding could be pre-hydrided at temperatures below 400°C in pure hydrogen gas and that the growth of hydrides on the surface could be controlled by changing the surface condition of the samples and form a desired hydride rim on the outside diameter of the cladding. The work performed at Pacific Northwest National Laboratory since the issuing of the M2 milestone has focused its efforts to optimize the formation of a hydride rim on available zircaloy-4 cladding samples by controlling temperature variation and gas flow control during pre-hydriding treatments. Surface conditioning of the outside surface was also examined as a variable. The results of test indicate that much of the variability in the hydride thickness is due to temperature variation occurring in the furnaces as well as how hydrogen gas flows across the sample surface. Efforts to examine other alloys, gas concentrations, and different surface conditioning plan to be pursed in the next FY as more cladding samples become available

Shimskey, Rick W.; Hanson, Brady D.; MacFarlan, Paul J.

2013-09-30

121

{sup 18}F-FDG PET/CT bone/bone marrow findings in Hodgkin's lymphoma may circumvent the use of bone marrow trephine biopsy at diagnosis staging  

Energy Technology Data Exchange (ETDEWEB)

Accurate staging of Hodgkin's lymphoma (HL) is necessary in selecting appropriate treatment. Bone marrow trephine biopsy (BMB) is the standard procedure for depicting bone marrow involvement. BMB is invasive and explores a limited part of the bone marrow. {sup 18}F-FDG PET/CT is now widely used for assessing response to therapy in HL and a baseline study is obtained to improve accuracy. The aim of this retrospective analysis was to assess whether routine BMB remains necessary with concomitant {sup 18}F-FDG PET/CT. Data from 83 patients (newly diagnosed HL) were reviewed. All patients had received contrast-enhanced CT, BMB and {sup 18}F-FDG PET/CT. Results of BMB were not available at the time of {sup 18}F-FDG PET/CT imaging. Seven patients had lymphomatous involvement on BMB. Four patients had bone involvement on conventional CT (two with negative BMB). All patients with bone marrow and/or bone lesions at conventional staging were also diagnosed on {sup 18}F-FDG PET/CT scan. PET/CT depicted FDG-avid bone/bone marrow foci in nine additional patients. Four of them had only one or two foci, while the other had multiple foci. However, the iliac crest, site of the BMB, was not involved on {sup 18}F-FDG PET/CT. Osteolytic/sclerotic lesions matching FDG-avid foci were visible on the CT part of PET/CT in three patients. MRI ordered in three other patients suggested bone marrow involvement. Interim and/or end-therapy {sup 18}F-FDG PET/CT documented response of FDG-avid bone/bone marrow foci to chemotherapy in every patient. {sup 18}F-FDG PET/CT highly improves sensitivity for diagnosis of bone/bone marrow lesions in HL compared to conventional staging. (orig.)

Moulin-Romsee, Gerard [Universite Paris 7, Service de Medicine Nucleaire, Hopital Saint-Louis, Assistance Publique-Hopitaux de Paris (France); Institut Curie, Nuclear Medicine, Paris (France); Hindie, Elif; Filmont, Jean-Emmanuel; Moretti, Jean-Luc [Universite Paris 7, Service de Medicine Nucleaire, Hopital Saint-Louis, Assistance Publique-Hopitaux de Paris (France); Cuenca, Xavier; Brice, Pauline; Sibon, David [Hopital Saint-Louis, Haemato-Oncology, Paris (France); Decaudin, Didier; Anitei, Marcela [Institut Curie, Haematology, Paris (France); Benamor, Myriam [Institut Curie, Nuclear Medicine, Paris (France); Briere, Josette [Hopital Saint-Louis, Pathology, Paris (France); Kerviler, Eric de [Hopital Saint-Louis, Radiology, Paris (France)

2010-06-15

122

Measurement of the wear of railway wheel-rims by radioisotopes  

International Nuclear Information System (INIS)

A relative measuring method based on the ratio of the activities of prepared railway wheel-rim surfaces before and after the wear test was developed and tested. In a 5 ?m thick plated layer 59Fe isotope was electrolitically deposited onto the rim surface. The relative decrease of the recorded intensities and the application of the Wickers-track technique provide a rapid and reliable method to measure the wear of railway wheel-rim under operation conditions. (Sz.J.)

123

Experimental investigation of the nebular formation of chondrule rims and the formation of chondrite parent bodies  

OpenAIRE

We developed an experimental setup to test the hypothesis that accretionary dust rims around chondrules formed in the solar nebula at elevated temperatures. Our experimental method allows us to form dust rims around chondrule-analogs while being levitated in an inert-gas flow. We used micrometer-sized powdered San Carlos olivine to accrete individual dust particles onto the chondrule-analog at a temperature of 1100{\\deg}C. The resulting dust-rims were analyzed by means of tw...

Beitz, Eike; Blum, Ju?rgen; Mathieu, Romain; Pack, Andreas; Hezel, Dominik C.

2011-01-01

124

RIM, Munc13, and Rab3A interplay in acrosomal exocytosis  

International Nuclear Information System (INIS)

Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: ? RIM and Munc13 are present in human sperm and localize to the acrosomal region. ? RIM and Munc13 are necessary for acrosomal exocytosis. ? RIM and Munc13 participate before the acrosomal calcium efflux. ? RIM, Munc13 and Rab3A interplay in human sperm acrosomal exocytosis. ? RIM and Rab3A have critical roles in membrane docking.

125

Enchondroma on bone scan in a patient with breast cancer  

International Nuclear Information System (INIS)

A 45-year-old postmenopausal woman with breast cancer was treated with modified radical mastectomy and radiotherapy. She remained clinically well for two years but then complained of pain in the left upper arm during a routine follow-up visit with her physician. A roentgenogram of the left proximal humerus showed a densely sclerotic, nonhomogeneous, 2 x 6 cm lesion with stippled calcification, the appearance of which was most consistent with a mature enchondroma or bone infarct. Because metastatic breast cancer was also a possibility, a technetium Tc 99m methyldiphosphonate (MDP) bone scan was done, revealing diffuse uptake in the left proximal humeral lesion, without any other area of involvement. Although radiologically the lesion appeared benign and stable, the history of breast cancer, abnormal bone scan, and pain could not be ignored, and open surgical bone biopsy was done. From deep within the lesion at the core of the metaphysis of the proximal left humerus, the surgeon removed an enchondroma, but found no evidence of metastatic disease. Follow-up MDP bone scans after six months and four years were unchanged

126

The Shape of the Inner Rim in Proto-Planetary Disks  

CERN Document Server

This paper discusses the properties of the inner puffed-up rim which forms in circumstellar disks when dust evaporates. We argue that the rim shape is controlled by a fundamental property of circumstellar disks, namely their very large vertical density gradient, through the dependence of grain evaporation temperature on gas density. As a result, the bright side of the rim is "curved", rather than "vertical", as expected when a constant evaporation temperature is assumed. We have computed a number of rim models, which take into account this effect in a self-consistent way. The results show that the curved rim (as the vertical rim) emits most of its radiation in the near and mid-IR, and provides a simple explanation to the observed values of the near-IR excess (the "3 micron bump" of Herbig Ae stars). Contrary to the vertical rim, for curved rims the near-IR excess does not depend much on the inclination, being maximum for face-on objects. We have then computed synthetic images of the curved rim seen under diff...

Isella, A; Isella, Andrea; Natta, Antonella

2005-01-01

127

Bone Crusher  

Science.gov (United States)

Students use a tension-compression machine (or an alternative bone-breaking setup) to see how different bones fracture differently and with different amounts of force, depending on their body locations. Teams determine bone mass and volume, calculate bone density, and predict fracture force. Then they each test a small animal bone (chicken, turkey, cat) to failure, examining the break to analyze the fracture type. Groups conduct research about biomedical challenges, materials and repair methods, and design repair treatment plans specific to their bones and fracture types, presenting their design recommendations to the class.

National Science Foundation GK-12 and Research Experience for Teachers (RET) Programs,

128

"Repair of cranial bone defects using endochondral bone matrix gelatin in rat "  

Directory of Open Access Journals (Sweden)

Full Text Available Bone matrix gelatin (BMG has been used for bone induction intramuscularly and subcutaneously by many investigators since 1965. More recently, some of the researchers have used BMG particles for bone repair and reported various results. In present study for evaluation of bone induction and new bone formation in parital defects, BMG particles were used in five groups of rats. The BMG was prepared as previously described using urist method. The defects wee produced with 5 –mm diameter in pariteal bones and filled by BMG particles. No BMG was used in control group.For evaluation of new bone formation and repair, the specimens were harvested on days 7 , 14 , 21 and 28 after operation. The samples were processed histologically, stained by H& E, alizarin red S staining, and Alcian blue, and studied by a light microscope.The results are as follows:In control group: Twenty-eight days after operation a narrow rim of new bone was detectable attached to the edge of defect.In BMG groups: At day 7 after operation young chondroblast cells appeared in whole area of defect. At 14th day after operation hypertrophic chondrocytes showed by Alcian blue staining and calcified cartilage were detectable by Alizarin red S staining. The numerous trabeculae spicules, early adult osteocytes and highly proliferated red bone marrow well developed on dayd 21 . finally typic bone trabeculae with regulated osteoblast cells and some osteoclast cells were detectable at day 28 after operation. In conclusion,BMG could stimulate bone induction and new bone formation in bony defects. So, it seems that BMG could be a godd biomaterial substance for new bone inducation in bone defects

"Sobhani A

2001-05-01

129

Communities of constructional lips and cup reef rims in Bermuda  

Science.gov (United States)

Constructional lips and cup reef rims are little studied reef features typical of very turbulent conditions. The relatively low diversity community of these structures consists of three components, and algal mat dominated by Herposiphonia secunda, an encrusting calcareous biota characterised by crustose coralline algae and the vermetid gastropod Dendropoma corrodens, which together are the main hermatypic components, and an endolithic component with very abundant boring sponges, polychaetes, crustaceans and sipunculids. In northerly areas of Bermuda, the hydrozoan Millepora alcicornis is a prominent member of the community while to the south the urchin Echinometra lucunter is abundant. On the south side of Bermuda the community traps sediment which is deposited in the void spaces. The environment shows reduced grazing and this may account for the presence of several relict and rare species.

Thomas, Martin L. H.; Stevens, Jo-Anne

1991-01-01

130

DATA MINING: A ‘RIM’ ALGORITHM FOR SPYWARE DETECTION WITH PRUNING  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this paper is to employ the principles of data mining and classify a new algorithm. In this method, we have proposed a new anti-spyware system (Spyware Detection, which is capable for classifying spyware files from legitimate files. Also we have evaluated the performance of our anti-spyware system with the existing anti- spywares in terms of overall accuracy (ACC and false positive rate (FPR... This paper describes the use of classification trees and shows the methods of pruning them using the new Algorithm.The RIM algorithm which can be classified and compared with other algorithms like Naïve Bayes, HNB (Hidden Naïve Bayes , Random Tree Algorithm The experimental results suggest that our method is better than the existing methods and shows the best result.

Mrs. Indulakshmi

2014-05-01

131

Infecção gonocócica em rim carcinomatoso / Gonococcal infection in carcinomatous kidney  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Os A.A. observaram um caso de infecção renal gonocócica, que relatam com as necessarias minucias, tanto sob o ponto de vista clinico-cirurgico como bacteriologico. 2 - Revendo a bibliografia sobre o assunto, verificaram que as infecções renais gonocócias são raras, e rarissimas as que apresentam pro [...] vas de identificação bacteriologica completa do gonocóco, como se fez no presente caso que deve figurar em 15º lugar, desde a descoberta do germen por Neisser, ha 59 anos. 3 - As provas bacteriologicas consistiram no exame bacterioscopico do sedimento urinario e pús renal, caracteres das colonias e culturas, seguidas de exames de esfregaços, provas de fermentação de glicose e maltose; sôro aglutinação e gono fixação. Todas as provas foram positivas para o gonocóco. 4- O rim não deve ser favoravel á proliferação do gonocóco, ou pela natureza do seu epitelio ou pela secreção de substancias que impeçam o seu desenvolvimento ou outra causa qualquer. Dada a frequencia das infecções gonocócicas no parelho urinario inferior, seria de esperar que, em grande numero de casos, fosse atingido o superior.5 - Como causas predisponentes a esse ataque secundario que se processa por vias sanguinea, linfatica ou contiguidade, cita Uhle as seguintes: 1º - perturbações congenitas, lesões obstrutoras, principalmente do ureter. 2º - calculos, tumores, etc. 3º - traumatismos seguidos de rutura e hemorragia e 4º - antecedentes patologícos não demonstrados. O nosso caso cabe no 2º paragrafo. O rim apresentava um tumor maligno e tinha inumeros calculos. 6 - Depois que o rim foi retirado pela intervenção cirurgica, que correu sem acidentes, o doente entrou logo a melhorar, tendo alta curado, do Hospital. Nada tem havido, até a presente data, que faça suspeitar, no desenvolvimento de qualquer metastase do tumor. Aliás, a operação foi indicada em virtude do estado infeccioso, sendo posterior á mesma a descoberta do carcinoma. 7 - Interessante referir tambem que, muito embora o rim estivesse atacado pelo gonocóco, o aparelho urinario inferior nada acusou nesse sentido, nem antes da operação, nem depois do doente ter tido alta. 8 - Casos como o presente, se bem que raros, pois que assim se têm mostrado nos centros onde a pesquiza é sistematica, devem aparecer outras vezes, sendo, portanto, sempre aconselhavel o exame bacteriologico dos casos de infecções renais supuradas. Abstract in english 1 - The AA. observed a case of gonococcal infection of kidney which they report with the necessary details, both from the clinico-surgical and bacteriological standpoints. 2 - In perusing the bibliography on the matter, they verified that gonococcal infections of kidney are rare, and very rare those [...] which present proofs of thorough bacteriological identification of the gonococcus, such as was furnished in the present case, which should occupy the 15th place since the discovery of the germ by Neisser, 59 years ago. 3 - In the bacterioscopical examination of the urinary sediment and of the pus from the kidney the bacteriological proofs are constituted by the characteristic features of the colonies and cultures, followed by examinations of the smears, by fermentation tests for glucose and maltose, by sero-agglutination and gono-fixation. All tests were positive for gonococcus. 4 - The kidney does not favour the proliferation of the gonococcus, either thanks to the nature of its epithelium, or thanks to the secretion of substances which prevent the development of the gonococcus, or thanks to any other cause. Taking into consideration the frequency of gonococcal infections of the lower urinary apparatus, it was to be expected that also the upper one should be attained in a great deal of cases. 5 - As to the causes which predispose to such a secondary attack proceeding by the way of blood, of lymphatic current or by contiguity, uhle quotes the following: 1º - Congenital disorders, obstruction changes, mainly of the ureter; 2º

Jorge de, Gouvêa; J. Guilherme, Lacorte.

132

Donor corneoscleral rim contamination by gentamicin-resistant organisms  

Directory of Open Access Journals (Sweden)

Full Text Available Gentamicin is the most widely used antibiotic in the decontamination of donor cornea for penetrating keratoplasty. However, the incidence of resistance to gentamicin is on the rise. Bacterial isolates from 178 donor corneal rims were studied for gentamicin sensitivity. The overall rate of gentamicin resistance was 63.4%. At 86.2% the Pseudomonas. species had the highest rate of resistance, followed by Streptococci at 84.6%. The high rate of gentamicin resistance encountered by us and others suggest that either addition of a second antibiotic to corneal storage media or replacement of gentamicin by an antibiotic with a broader spectrum of activity may help reduce the risk of endophthalmitis following penetrating keratoplasty

Gopinathan Usha

1994-01-01

133

Windage rise and flowpath gas ingestion in turbine rim cavities  

Science.gov (United States)

A method for modeling the windage rise and flowpath gas ingestion in turbine rim cavities on a macroscopic scale is presented, with application to the minimization of the necessary required cooling air in order to provide optimum turbine cycle performance and hardware durability. Comparison is made between measured and predicted results for: (1) the prediction of critical flow in a turbine aeroperformance rig; (2) a boltless blade retainer design; (3) the impact of instrumentation wire; and (4) a modulated throughflow test. It is noted that the effects of inner and outer flow extraction, rotor and stator drag, rotor and stator bolt drag, leakages, and injection momentum must be accounted for to accurately model the wheel space.

Haaser, Fred; Jack, James; McGreehan, William

1987-05-01

134

The Thin X-ray Rims of SN1006  

Science.gov (United States)

The historical supernova remnant SN 1006 AD and several other young supernova remnants (SNRs) display sharp X-ray synchrotron rims along their edges. These rims are very narrow, requiring the abrupt disappearance of either relativistic electrons or magnetic field downstream. If synchrotron losses on electrons are responsible, magnetic fields must be amplified by orders of magnitude in the shock. We present new Chandra observations of SN 1006, including the first long exposure of the southwest limb, and measure the filament widths in the ranges 0.5 to 1, 1 to 2, and 2 to 7 keV. We interpret them with three theoretical models: synchrotron losses on diffusing or on convecting electrons, or damping of temporary magnetic turbulence. Differentiating among these models is important, as post-shock magnetic field amplification has direct implications for the possibility of SNRs accelerating cosmic rays up to the “knee” in the integrated cosmic-ray spectrum around 3000 TeV. To do this, we primarily consider the energy dependence of filament widths in the 0.5-7 keV band. For all three models, we also derive estimates of the post-shock magnetic field through both simple approximations and full numerical calculations. We find that profiles at a specific energy can be well fit by any of the three models, but the approximate scaling of the widths with energy ( E-.2 to E-.5) requires a hybrid model. We also confirm that significant magnetic-field amplification is required for all models, with average post-shock estimates ranging from ~ 70 ?G -120 ?G in the northeast and ~ 60 ?G-110 ?G in the southwest. This work is supported by NASA through grant GO2-13066A.

Ressler, Sean; Reynolds, S. P.; Winkler, P. F.; Hwang, U.; Katsuda, S.; Long, K. S.; Petre, R.; Williams, B. J.

2013-01-01

135

Out of the Blue: The Pacific Rim as a Region  

Directory of Open Access Journals (Sweden)

Full Text Available In 1993, in advance of what was to be the first Asia Pacific Economic Cooperation (APEC leader’s summit, US president Bill Clinton gave a lecture at Waseda University in Japan. In his speech, Clinton called for the creation of a “community of the Pacific.” The idea of a Pacific community is neither Clinton’s nor the Democratic Party’s invention, however. In the previous decade Ronald Reagan had already used it, going even beyond later conceptualizations, by referring to the 21st century as the Pacific’s century. But Reagan's prophecy concerning the Great Ocean was not new back in the 1980s either. In 1900 then US Secretary of State John Hay wrote: “the Mediterranean is the ocean of the past, the Atlantic the ocean of the present and the Pacific is the ocean of the future.” In a more general manner, as Christopher Coker has observed, the notion of the “Century of the Pacific” is plausible because it is consistent with the idea, popularized by Hegel, that the spirit of civilization is moving toward that part of the globe. Thus, the century of the Pacific has become a kind of zeitgeist. In this paper I undertake a conceptual, historical, and theoretical journey through the “Pacific Rim” or “Asia-Pacific,” as it has been called more recently. Although I will question the utility of the term, I want to make clear that my purpose is only to undertake a critical survey of “the Pacific.” As in any trip, however, one needs a starting point. But, What is the starting point of the Pacific Rim, that geographic zone that has been compared to Pascal’s sphere: “with periphery indeterminable and a center that may be anywhere”?

Arturo Santa-Cruz

2005-08-01

136

Radial Internal Material Handling System (RIMS) for Circular Habitat Volumes  

Science.gov (United States)

On planetary surfaces, pressurized human habitable volumes will require a means to carry equipment around within the volume of the habitat, regardless of the partial gravity (Earth, Moon, Mars, etc.). On the NASA Habitat Demonstration Unit (HDU), a vertical cylindrical volume, it was determined that a variety of heavy items would need to be carried back and forth from deployed locations to the General Maintenance Work Station (GMWS) when in need of repair, and other equipment may need to be carried inside for repairs, such as rover parts and other external equipment. The vertical cylindrical volume of the HDU lent itself to a circular overhead track and hoist system that allows lifting of heavy objects from anywhere in the habitat to any other point in the habitat interior. In addition, the system is able to hand-off lifted items to other material handling systems through the side hatches, such as through an airlock. The overhead system consists of two concentric circle tracks that have a movable beam between them. The beam has a hoist carriage that can move back and forth on the beam. Therefore, the entire system acts like a bridge crane curved around to meet itself in a circle. The novelty of the system is in its configuration, and how it interfaces with the volume of the HDU habitat. Similar to how a bridge crane allows coverage for an entire rectangular volume, the RIMS system covers a circular volume. The RIMS system is the first generation of what may be applied to future planetary surface vertical cylinder habitats on the Moon or on Mars.

Howe, Alan S.; Haselschwardt, Sally; Bogatko, Alex; Humphrey, Brian; Patel, Amit

2013-01-01

137

Imaging features of low-grade central osteosarcoma of the long bones and pelvis  

Energy Technology Data Exchange (ETDEWEB)

To determine the age and gender distribution and imaging features of low-grade central osteosarcoma (LGCOS) of the long bones and pelvis and to discuss our findings in the context of lesions for which LGCOS has been mistaken. We reviewed 99 cases of LGCOS collected between 1919 and 2002 from our institution and pathology consultation files. Adequate imaging was available in 70 cases (36 radiographs only, 17 radiographs/CT, 12 radiographs/MRI, 2 radiographs/CT/MRI, 2 CT only, 1 MRI only, 5 bone scans). Patient average age was 30.1{+-}14.2 years, with a slight female predominance. The femur and tibia were the most common long bones involved (29 and 20 each) with the majority of these tumors arising around the knee, followed by the fibula, radius, humerus and ulna (four, three, two and one case each). Flat bones were involved in six cases (three pelvis, one rib, two scapulae). Short tubular bones were involved in five cases (two metatarsal, two phalanges, one clavicle). The lesion extended to the end of the affected long bone in 22 of 59 cases. Lesions were large at presentation (mean 7.9{+-}4.6 cm, range 2-24). Four radiographic patterns were identified: lytic with varying amounts of thick and coarse trabeculation (n=22), predominantly lytic with few thin, incomplete trabecula (n=21), densely sclerotic (n=17) and mixed lytic and sclerotic (n=10). Lesions were benign-appearing overall with focally aggressive features. CT or MRI demonstrated cortical breech or extension into the soft tissues in all cases. LGCOS has a variable appearance on radiographs. A frequent pattern is a slow-growing large intracompartmental fibro-osseous lesion with varying amounts of septal ossification associated with focal areas of aggression. A homogeneously sclerotic pattern was also noted. Imaging with CT or MRI was helpful in every instance in our series in identifying areas of soft tissue extension or cortical disruption suggestive of a low-grade malignancy. (orig.)

Andresen, Kelli J.; Sundaram, Murali [Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN (United States); Unni, K. Krishnan [Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN (United States); Sim, Franklin H. [Department of Orthopedic Surgery, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN (United States)

2004-07-01

138

Imaging features of low-grade central osteosarcoma of the long bones and pelvis  

International Nuclear Information System (INIS)

To determine the age and gender distribution and imaging features of low-grade central osteosarcoma (LGCOS) of the long bones and pelvis and to discuss our findings in the context of lesions for which LGCOS has been mistaken. We reviewed 99 cases of LGCOS collected between 1919 and 2002 from our institution and pathology consultation files. Adequate imaging was available in 70 cases (36 radiographs only, 17 radiographs/CT, 12 radiographs/MRI, 2 radiographs/CT/MRI, 2 CT only, 1 MRI only, 5 bone scans). Patient average age was 30.1±14.2 years, with a slight female predominance. The femur and tibia were the most common long bones involved (29 and 20 each) with the majority of these tumors arising around the knee, followed by the fibula, radius, humerus and ulna (four, three, two and one case each). Flat bones were involved in six cases (three pelvis, one rib, two scapulae). Short tubular bones were involved in five cases (two metatarsal, two phalanges, one clavicle). The lesion extended to the end of the affected long bone in 22 of 59 cases. Lesions were large at presentation (mean 7.9±4.6 cm, range 2-24). Four radiographic patterns were identified: lytic with varying amounts of thick and coarse trabeculation (n=22), predominantly lytic with few thin, incomplete trabecula (n=21), densely sclerotic (n=17) and mixed lytic and sclerotic (n=10). Lesions were benign-appearing overall with focally aggressive features. CT or MRI demonstrated cortical breech or extension into rated cortical breech or extension into the soft tissues in all cases. LGCOS has a variable appearance on radiographs. A frequent pattern is a slow-growing large intracompartmental fibro-osseous lesion with varying amounts of septal ossification associated with focal areas of aggression. A homogeneously sclerotic pattern was also noted. Imaging with CT or MRI was helpful in every instance in our series in identifying areas of soft tissue extension or cortical disruption suggestive of a low-grade malignancy. (orig.)

139

Bone Densitometry  

Medline Plus

Full Text Available ... less frequently. Osteoporosis is a major cause of hip and vertebral fractures in older people. Our bones ... weaker, it breaks easier. New bone in the hips and vertebrae has the highest possibility of becoming ...

140

Bone tumor  

Science.gov (United States)

... physical exam. Tests that may be done include: Alkaline phosphatase blood level Bone biopsy Bone scan Chest x- ... also affect the results of the following tests: Alkaline phosphatase isoenzyme Blood calcium level Parathyroid hormone Blood phosphorus ...

141

Bone Densitometry  

Medline Plus

Full Text Available ... well as bed rest, weakens the bones. A diet low in dairy products and calcium can make ... with oral medication, staying active and a healthy diet. Bone density tests are available and very helpful ...

142

Imaging of the intramedullary bone infarcts and their complications  

International Nuclear Information System (INIS)

Radiographic, CT, bone scan and MR patterns of the infarcts of the metaphyses and diaphyses of tubular bones and their main complications are presented. Bone marrow infarcts are located in the medullary cavity of long bones. They most often involve the lower limbs. They are commonly associated with necrosis of the epiphyses and have common origin. In contrast to necrosis of the epiphyses, bone infarcts may present specific complications. They are most often detected incidentally, because of their clinical latency. Radiographic and CT changes appear late, showing localized areas of increased density with irregular rims, or sharply demarcated shells of calcification. Earlier changes are demonstrated by bone scan and MRI. MR pattern is characteristic, showing an area of hyposignal on T1- and T2-weighted sequences, with irregular rims, and sometimes small areas of fat signal. Their complications include cystic formation and malignant degeneration (sarcoma and particularly malignant fibrous histiocytoma). An unusual complication, infection involving bone infarcts is also presented. (authors). 12 refs., 8 figs

143

Synchrotron X-Ray Rims in Tycho's Supernova Remnant are Energy Dependent  

Science.gov (United States)

Several young supernova remnants exhibit thin X-ray bright rims of synchrotron radiation at their forward shocks. Thin rims have been taken to indicate that shock-accelerated electrons rapidly cool downstream of the shock, requiring strong magnetic field amplification. But, magnetic field damping immediately behind the shock could produce similarly thin rims. Synchrotron loss-limited rim widths should decrease with energy whereas damping limited rims should be relatively energy-independent. To discriminate between models, we measured rim widths around Tycho's supernova remnant in 5 energy bands using an archival 750 ks Chandra observation. Rims narrow with increasing energy, favoring loss-limited radiation over magnetic damping and corroborating similar observations in the remnant of SN 1006. Observed widths are best fit by electron transport models requiring amplified magnetic fields of ~200-1000 µG and particle diffusion coefficients ~1-100x Bohm values, consistent with prior work on Tycho's SNR. Non-negligible diffusion results in some degeneracy between magnetic field strength and diffusion coefficient in setting observed rim widths, but strong magnetic fields are required for all measurements. A different approach may be needed to better constrain diffusion at supernova remnant shocks.

Tran, Aaron; Williams, Brian J.; Petre, Robert; Ressler, Sean; Reynolds, Stephen P.

2015-01-01

144

Bestimmung der Ionisationsenergie von Actinium und Ultraspurenanalyse von Plutonium mit resonanter Ionisationsmassenspektrometrie (RIMS)  

OpenAIRE

ZusammenfassungDie Resonanzionisationsmassenspektrometrie (RIMS) verbindet hohe Elementselektivität mit guter Nachweiseffizienz. Aufgrund dieser Eigenschaften ist die Methode für Ultraspurenanalyse und Untersuchungen an seltenen oder schwer handhabbaren Elementen gut geeignet. Für RIMS werden neutrale Atome mit monochromatischem Laserlicht ein- oder mehrfach resonant auf energetisch hoch liegende Niveaus angeregt und anschließend durch einen weiteren Laserstrahl oder durch ein elektrische...

Waldek, Achim Marcus

2001-01-01

145

Tumor primitivo neuroectodérmico de rim em criança Primitive neuroectodermal tumor of the kidney in children  

OpenAIRE

Objetivos: Caracterizar o tumor primitivo neuroectodérmico de rim como diagnóstico diferencial de tumor de Wilms e enfatizar a gravidade da doença. Métodos: Apresentamos um paciente com diagnóstico de tumor primitivo neuroectodérmico de rim, submetido a nefrectomia e ressecção completa do tumor, associadas a quimioterapia. Resultado: Inicialmente o paciente apresentou evolução favorável ao tratamento realizado, com poucas intercorrências, as quais eram relacionadas principalmente ...

Kuczynski, Ana P.; Gugelmin, Elizabeth S.; Netto, Rodrigo A. S.

2001-01-01

146

Bone Basics  

Science.gov (United States)

This is an activity (on page 2 of the PDF) about the two main components of bone - collagen and minerals (like calcium) - and how they each contribute to its flexibility and strength. Learners will submerge 3 chicken bones in water, bleach, and vinegar, wait 24 hours, then observe and test each bone. This resource includes information about how nanoscientists are trying to produce artificial analogs to these components and relates to linked video, DragonflyTV Nano: Bone Regrowth.

Twin Cities Public Television, Inc.

2008-01-01

147

Bone scan  

Science.gov (United States)

A bone scan is an imaging test that shows areas of increased or decreased bone turnover ( metabolism ). ... have taken up less of the radioactive material. Bone scan findings must be compared with other imaging studies, in addition to clinical information. Your health ...

148

Anion recognition properties of new upper-rim bis[rhenium(I) bipyridyl, ruthenium(II) bis(bipyridyl), cobaltocenium]calix[4]arene receptors dictated by lower-rim substituents  

OpenAIRE

New upper-rim bis[rhenium(I) bipyridyl, ruthenium(II) bis(bipyridyl), cobaltocenium]calix[4]arene receptors exhibit remarkable dihydrogen phosphate selective anion recognition properties dictated by the relative positions of lower-rim tosyl substituents.

Beer, Pd; Drew, Mgb; Hesek, D.; Shade, M.; Szemes, F.

1996-01-01

149

Bone metastases as the presenting manifestation of rhabdomyosarcoma in childhood  

International Nuclear Information System (INIS)

Rarely, rhabdomyosarcoma can present with bone pain and bone lesions on radiographs without evidence of a primary tumor. Of 428 children with biopsy-proven rhabdomyosarcoma, four presented with radiographic evidence of bone metastases, but no primary tumor was found on subsequent evaluation. On radiographs, these metastases, located most commonly in the metaphyses of the extremities and in the spine, displayed a destructive or diffusely permeative pattern without sclerotic margins and mimicked the more common neuroblastoma. One patient also had diaphyseal cortical lytic metastases of the tibia. Radiographs defined metastases of the extremities better than the correlative bone scans. In the spine, on T2-weighted magnetic resonance (MR) images, metastases displayed high signal intensity which contrasted with the low-signal-intensity marrow in these pediatric patients. On histopathologic examination, metastatic rhabdomyosarcoma was composed of small cells of variable size, shape, and growth pattern similar to other round cell tumors. A positive desmin immunohistochemical test helped to establish the diagnosis. The radiologist, pathologist, and clinician should be aware of this unusual presentation of rhabdomyosarcoma so that suitable immunohistochemical tests are performed and appropriate chemotherapy given. (orig.)

150

CT Guided Bone Biopsy Using a Battery Powered Intraosseous Device  

International Nuclear Information System (INIS)

Purpose: To evaluate the feasibility of a battery powered intraosseous device to perform CT-fluoroscopy guided bone biopsy. Methods: Retrospective analysis of 12 patients in whom bone specimen were acquired from different locations under CT-fluoroscopy guidance using the OnControl bone marrow biopsy system (OBM, Vidacare, Shavano Park, TX, USA). Data of the 12 were compared to a historic cohort in whom the specimen were acquired using the classic Jamshidi Needle, as reference needle using manual force for biopsy. Results: Technical success was reached in 11 of 12 cases, indicated by central localisation of the needle within the target lesion. All specimen sampled were sufficient for histopathological workup. Compared to the historical cohort the time needed for biopsy decreased significantly from 13 ± 6 to 6 ± 4 min (P = 0.0001). Due to the shortened intervention time the radiation dose (CTDI) during CT-fluoroscopy was lowered significantly from 169 ± 87 to 111 ± 54 mGy × cm (P = 0.0001). Interventional radiologists were confident with the performance of the needle especially when using in sclerotic or osteoblastic lesions. Conclusion: The OBM is an attractive support for CT-fluoroscopy guided bone biopsy which is safe tool and compared to the classical approach using the Jamshidi needle leading to significantly reduced intervention time and radiation exposure

151

CT Guided Bone Biopsy Using a Battery Powered Intraosseous Device  

Energy Technology Data Exchange (ETDEWEB)

Purpose: To evaluate the feasibility of a battery powered intraosseous device to perform CT-fluoroscopy guided bone biopsy. Methods: Retrospective analysis of 12 patients in whom bone specimen were acquired from different locations under CT-fluoroscopy guidance using the OnControl bone marrow biopsy system (OBM, Vidacare, Shavano Park, TX, USA). Data of the 12 were compared to a historic cohort in whom the specimen were acquired using the classic Jamshidi Needle, as reference needle using manual force for biopsy. Results: Technical success was reached in 11 of 12 cases, indicated by central localisation of the needle within the target lesion. All specimen sampled were sufficient for histopathological workup. Compared to the historical cohort the time needed for biopsy decreased significantly from 13 {+-} 6 to 6 {+-} 4 min (P = 0.0001). Due to the shortened intervention time the radiation dose (CTDI) during CT-fluoroscopy was lowered significantly from 169 {+-} 87 to 111 {+-} 54 mGy Multiplication-Sign cm (P = 0.0001). Interventional radiologists were confident with the performance of the needle especially when using in sclerotic or osteoblastic lesions. Conclusion: The OBM is an attractive support for CT-fluoroscopy guided bone biopsy which is safe tool and compared to the classical approach using the Jamshidi needle leading to significantly reduced intervention time and radiation exposure.

Schnapauff, Dirk, E-mail: dirk.schnapauff@charite.de; Marnitz, Tim, E-mail: tim.marnitz@charite.de; Freyhardt, Patrick, E-mail: Patrick.freyhardt@charite.de; Collettini, Federico, E-mail: Federico.collettini@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany); Hartwig, Kerstin, E-mail: kerstin.hartwig@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Haematology and Oncology (Germany); Joehrens, Korinna, E-mail: korinna.joehrens@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Pathology (Germany); Hamm, Bernd, E-mail: bernd.hamm@charite.de; Kroencke, Thomas, E-mail: thomas.kroencke@charite.de; Gebauer, Bernhard, E-mail: Bernhard.gebauer@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany)

2013-10-15

152

A NEUTRAL UPPER TO LOWER RIM LINKED BIS-CALIX[4]ARENE RECEPTOR THAT RECOGNIZES ANIONIC GUEST SPECIES  

OpenAIRE

The synthesis of a novel neutral fluoride anion selective bis-calix[4]arene receptor is described in which the upper rim of one calix[4]arene moiety is linked via amide bonds to the lower rim of another.

Beer, P.; Gale, P.; Hesek, D.

1995-01-01

153

Comperative study on four different radiographic technics to image the navicular bone  

International Nuclear Information System (INIS)

In this paper the conventional x-ray technique according to Oxspring is compared with tomography and digitalized picture techniques (digital luminescent radiography, computed tomography, nuclear magnetic resonance tomography) to establish whether an improved picture of the equine navicular bone is possible. Because of a lack of detail, nuclear magnetic resonance tomography and digital luminescent radiography show no advantage. With tomography good picture of the navicular bone as well as the sesamoidian canals is gained, but the bone structure is not sharply visible. In spite of small losses in picture resolution, the computed tomography gives a picture with good contour and bone structure as well as an excellent differentiation between the density of spongiotic and sclerotic bone. When considering the picture quality (contour and structure of the navicular bone as well as number, shape, depth and surroundings of the sesamoidian canals), costs and technical possibilities of the examination procedures, the x-ray technique according to Oxspring still remains the method of choice in examining the equine navicular bone

154

A SCUBA survey of bright-rimmed clouds  

CERN Document Server

Context: Bright-rimmed clouds (BRCs) are potential examples of triggered star formation regions, in which photoionisation driven shocks caused by the expansion of HII regions induce protostellar collapse within the clouds. Aims: The main purpose of the paper is to establish the level of star formation occuring within a known set of BRCs. A secondary aim is to determine the extent, if any, to which this star formation has been promulgated by the process of photoionisation triggering. Methods:A primary set of observations is presented obtained with submillimeter SCUBA observations and archival data from near-IR and mid- to far-IR have been explored for relevant observations and incorporated where appropriate. Results:SCUBA observations show a total of 47 dense cores within the heads of 44 observed BRCs drawn from a catalogue of IRAS sources embedded within HII regions, supportive of the scenario proposed by RDI models. The physical properties of these cores indicate star formation across the majority of our sam...

Morgan, L K; Urquhart, J S; White, G J

2007-01-01

155

Rim enhancement of meningiomas on fast FLAIR imaging  

International Nuclear Information System (INIS)

We investigated the enhancement patterns of meningiomas on fast fluid-attenuated inversion-recovery (FLAIR) images and related them to the size and histology of the tumour and the associated oedema. We studied 30 meningiomas with T2-weighted fast spin-echo (SE) images plus T1-weighted SE images with magnetisation-transfer saturation and fast FLAIR before and after contrast enhancement at 0.5 tesla. There were 21 meningiomas (70%) which showed peripheral (rim) enhancement on fast FLAIR, while only one, which showed heavy central calcification, enhanced peripherally on the SE images. Of the meningiomas with capsular enhancement on fast FLAIR 20 (95%) were more than 2 cm in diameter. The nine 9 smaller meningiomas enhanced homogeneously. This difference was statistically significant pattern (P <0.01). All meningiomas which had associated oedema showed the capsular pattern although their number (6; 20%) was to small to analyse statistically. Only 11 (36%) tumours were examined histologically; peripheral enhancement was observed in all types of meningioma. This pattern may help to differentiate meningiomas from other extra-axial masses. (orig.)

156

The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host.  

Science.gov (United States)

The Rim101 protein is a conserved pH-responsive transcription factor that mediates important interactions between several fungal pathogens and the infected host. In the human fungal pathogen Cryptococcus neoformans, the Rim101 protein retains conserved functions to allow the microorganism to respond to changes in pH and other host stresses. This coordinated cellular response enables this fungus to effectively evade the host immune response. Preliminary studies suggest that this conserved transcription factor is uniquely regulated in C. neoformans both by the canonical pH-sensing pathway and by the cyclic AMP (cAMP)/protein kinase A (PKA) pathway. Here we present comparative transcriptional data that demonstrate a strong concordance between the downstream effectors of PKA and Rim101. To define Rim101-dependent gene expression during a murine lung infection, we used nanoString profiling of lung tissue infected with a wild-type or rim101? mutant strain. In this setting, we demonstrated that Rim101 controls the expression of multiple cell wall-biosynthetic genes, likely explaining the enhanced immunogenicity of the rim101? mutant. Despite its divergent upstream regulation, the C. neoformans Rim101 protein recognizes a conserved DNA binding motif. Using these data, we identified direct targets of this transcription factor, including genes involved in cell wall regulation. Therefore, the Rim101 protein directly controls cell wall changes required for the adaptation of C. neoformans to its host environment. Moreover, we propose that integration of the cAMP/PKA and pH-sensing pathways allows C. neoformans to respond to a broad range of host-specific signals. PMID:24324006

O'Meara, Teresa R; Xu, Wenjie; Selvig, Kyla M; O'Meara, Matthew J; Mitchell, Aaron P; Alspaugh, J Andrew

2014-02-01

157

99mTc MDP bone scan in evaluation of painful scoliosis  

International Nuclear Information System (INIS)

A 18-year-old male presented with low back ache. The patient was investigated and was diagnosed to have painful scoliosis. X-ray and other examinations could not reveal any diagnosis. The patient was referred to undergo bone scan on clinical suspicion of osteoid osteoma and to rule out stress fracture if any. Planar bone scan was performed, which showed a lesion in L3 vertebra and was further evaluated with SPECT (Single photon emission computed tomography) study to characterize the lesion. On SPECT examination, the classical features of osteoid osteoma, the double density sign (11), was noted in the pars interarticularis region. These findings were confirmed by a CT scan, which showed a sclerotic lesion in pars interarticularis of L3 vertebra. The patient was posted for operation and was relieved of symptoms in the postoperative follow-up. (author)

158

PET/MR imaging of bone lesions - implications for PET quantification from imperfect attenuation correction  

Energy Technology Data Exchange (ETDEWEB)

Accurate attenuation correction (AC) is essential for quantitative analysis of PET tracer distribution. In MR, the lack of cortical bone signal makes bone segmentation difficult and may require implementation of special sequences. The purpose of this study was to evaluate the need for accurate bone segmentation in MR-based AC for whole-body PET/MR imaging. In 22 patients undergoing sequential PET/CT and 3-T MR imaging, modified CT AC maps were produced by replacing pixels with values of >100 HU, representing mostly bone structures, by pixels with a constant value of 36 HU corresponding to soft tissue, thereby simulating current MR-derived AC maps. A total of 141 FDG-positive osseous lesions and 50 soft-tissue lesions adjacent to bones were evaluated. The mean standardized uptake value (SUVmean) was measured in each lesion in PET images reconstructed once using the standard AC maps and once using the modified AC maps. Subsequently, the errors in lesion tracer uptake for the modified PET images were calculated using the standard PET image as a reference. Substitution of bone by soft tissue values in AC maps resulted in an underestimation of tracer uptake in osseous and soft tissue lesions adjacent to bones of 11.2 {+-} 5.4 % (range 1.5-30.8 %) and 3.2 {+-} 1.7 % (range 0.2-4 %), respectively. Analysis of the spine and pelvic osseous lesions revealed a substantial dependence of the error on lesion composition. For predominantly sclerotic spine lesions, the mean underestimation was 15.9 {+-} 3.4 % (range 9.9-23.5 %) and for osteolytic spine lesions, 7.2 {+-} 1.7 % (range 4.9-9.3 %), respectively. CT data simulating treating bone as soft tissue as is currently done in MR maps for PET AC leads to a substantial underestimation of tracer uptake in bone lesions and depends on lesion composition, the largest error being seen in sclerotic lesions. Therefore, depiction of cortical bone and other calcified areas in MR AC maps is necessary for accurate quantification of tracer uptake values in PET/MR imaging. (orig.)

Samarin, Andrei [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); University Hospital Zurich, Nuclear Medicine, Zurich (Switzerland); Burger, Cyrill; Crook, David W.; Burger, Irene A.; Schmid, Daniel T.; Schulthess, Gustav K. von; Kuhn, Felix P. [University Hospital of Zurich, Department of Medical Radiology, Zurich (Switzerland); Wollenweber, Scott D. [GE Healthcare, Waukesha, WI (United States)

2012-07-15

159

RIM, Munc13, and Rab3A interplay in acrosomal exocytosis  

Energy Technology Data Exchange (ETDEWEB)

Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: Black-Right-Pointing-Pointer RIM and Munc13 are present in human sperm and localize to the acrosomal region. Black-Right-Pointing-Pointer RIM and Munc13 are necessary for acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Munc13 participate before the acrosomal calcium efflux. Black-Right-Pointing-Pointer RIM, Munc13 and Rab3A interplay in human sperm acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Rab3A have critical roles in membrane docking.

Bello, Oscar D.; Zanetti, M. Natalia [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Mayorga, Luis S. [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Michaut, Marcela A., E-mail: mmichaut@fcm.uncu.edu.ar [Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Instituto de Ciencias Basicas, Universidad Nacional de Cuyo, Mendoza (5500) (Argentina)

2012-03-10

160

LE RÔLE DE RIM101p DANS LA RÉPONSE AU pH CHEZ CANDIDA ALBICANS  

OpenAIRE

Rim101p est un facteur de transcription qui est activé par cleavage N-terminale à pH alcalin. Il régule ainsi la réponse au pH et joue aussi un rôle majeur dans la pathogenèse de la levure Candida albicans. Mon projet est d'identifier et d'étudier des gènes de surface régulés par Rim101p qui ont une fonction dans l'interaction hôte-levure.Une analyse du transcriptome suite à l'induction d'une forme tronquée et constitutivement active de Rim101p nous avait permis d'identifie...

Weyler, Michael

2007-01-01

161

A Diphenol Oxidase Gene Is Part of a Cluster of Genes Involved in Catecholamine Metabolism and Sclerotization in Drosophila. II. Molecular Localization of the Dox-A2 Coding Region  

OpenAIRE

Mutations at the Dox-A2 (2-53.9) locus alter the A2 component of diphenol oxidase, an enzyme having an important role in cuticle formation. This locus is in the dopa decarboxylase, Df( 2L)TW130 region, which contains a cluster of at least 14 genes involved in catecholamine metabolism and the formation, sclerotization and melanization of cuticle in Drosophila. The region is subdivided by deficiencies, and localization of breakpoints in cloned DNA reveals a dense subcluster of six genes in the ...

Pentz, Ellen Steward; Wright, Theodore R. F.

1986-01-01

162

The effect of vitamin A supplementation on retinoic acid-related orphan receptor ?t (ROR?t) and interleukin-17 (IL-17) gene expression in Avonex-treated multiple sclerotic patients.  

Science.gov (United States)

The aim of this study was to investigate the role of vitamin A on ROR?t and IL-17 gene expression in multiple sclerotic patients. Patients in the vitamin A group received 25,000 IU retinyl palmitate per day, while patients in the placebo group took one capsule of placebo per day for 6 months. Gene expression was measured by real-time PCR at the first and end of the study. The results of this study show that vitamin A downregulates IL-17 and ROR?t gene expression. No changes in gene expression occurred in the placebo group. PMID:23868508

Mohammadzadeh Honarvar, Niyaz; Harirchian, Mohammad Hossein; Koohdani, Fariba; Siassi, Feridoun; Abdolahi, Mina; Bitarafan, Sama; Salehi, Eisa; Sahraian, Mohammad Ali; Eshraghian, Mohammad Reza; Saboor-Yarghi, Ali Akbar

2013-11-01

163

Bone imaging  

International Nuclear Information System (INIS)

The ease of preparation of such radiopharmaceuticals which deliver a low total body radiation dose has revolutionized bone scanning and has relegated 85Sr and comparable agents to the past history of bone imaging. The search for elements which were metabolically similar to calcium in their uptake in the bone hydroxyapatite crystal has been abandoned in favor of a more empirical approach which exploits the nearly ideal physical and chemical properties of /sup 99m/Technetium. This radionuclide forms complexes with multiple compounds. It is labeled to phosphorus containing molecules to form a bone-seeking radiopharmaceutical which may give superior images of bony anatomy

164

cis- and trans-Acting Localization Determinants of pH Response Regulator Rim13 in Saccharomyces cerevisiae  

OpenAIRE

The Rim101/PacC pathway governs adaptation to alkaline pH in many fungi. Output of the pathway is mediated by transcription factors of the Rim101/PacC family, which are activated by proteolytic cleavage. The proteolytic complex includes scaffold protein Rim20 and endosome-associated subunits of the endosomal sorting complex required for transport (ESCRT). We provide here evidence that Saccharomyces cerevisiae Rim13, the protease that is implicated in Rim101 cleavage, is associated with the Ri...

Subramanian, Shoba; Woolford, Carol A.; Desai, Jigar V.; Lanni, Frederick; Mitchell, Aaron P.

2012-01-01

165

Varied Mechanisms for Star Formation in Bright-Rimmed Clouds  

Science.gov (United States)

Bright-rimmed clouds (BRCs) are potential examples of triggered star-formation regions, in which photoionisation driven shocks caused by the expansion of HII regions induce protostellar collapse within the clouds. A sample of optically bright BRCs at the edge of HII regions has been observed at multiple wavelengths in order to investigate the possibility that star-formation is present. Such activity may be related to photoionisation induced shocks caused by the massive stars powering the HII regions. The sample has been observed at radio, infrared and submillimetre wavelengths, these observations reveal dense cores present within the heads of 44 observed BRCs drawn from a catalogue of IRAS sources embedded within HII regions, supportive of the scenario proposed by radiatively driven implosion (RDI) models. The physical properties of these cores indicate the presence of star formation across the majority of our sample. This star-formation appears to be predominately in the regime of intermediate to high mass and may indicate the formation of clusters. IR observations indicate the association of early star forming sources with the sample. A fundamental difference appears to exist between different morphological types of BRC. Morphological variations in BRCs have previously been attributed to an evolutionary scenario of RDI. However, the physical properties of cores found within different types of BRC indicate that the strength of the ambient ionisation field is highly correlated with the attributes of certain cores, and not with others. The suggestion is that different morphological types of BRC have followed different evolutionary pathways, this is supported by the mass distributions of cores associated with the different morphologies.

Morgan, Larry; Urquhart, J.; Thompson, M.; White, G.; Figura, C.

2007-12-01

166

29 CFR 1910.177 - Servicing multi-piece and single piece rim wheels.  

Science.gov (United States)

...OCCUPATIONAL SAFETY AND HEALTH STANDARDS Materials Handling and Storage § 1910.177 Servicing multi-piece and single piece rim... Restraining device means an apparatus such as a cage, rack, assemblage of bars and other components that will...

2010-07-01

167

Search Efficient Representation of Healthcare Data based on the HL7 RIM  

Directory of Open Access Journals (Sweden)

Full Text Available The Reference Information Model (RIM of Health Level Seven (HL7 standard is a conceptual information model for health care. Data of HL7 RIM Observation class are sparse, high dimensional, and require frequent schema change. Entity Attribute Value (EAV is the widely used solution to handle these above challenges of medical data, but EAV is not search efficient for knowledge extraction. In this paper, we have proposed a search efficient data model:  Optimized Entity Attribute Value (OEAV for physical representation of medical data as alternative of widely used EAV model. We have implemented EAV or OEAV individually to model RIM Observation class and used relational model for the remaining RIM classes. We have shown that OEAV is dramatically search efficient   and occupy less storage space compared to EAV.

Razan Paul

2010-12-01

168

Signaling events of the Rim101 pathway occur at the plasma membrane in a ubiquitination-dependent manner.  

Science.gov (United States)

In yeast, external alkalization and alteration in plasma membrane lipid asymmetry are sensed by the Rim101 pathway. It is currently under debate whether the signal elicited by external alkalization is transduced to downstream molecules at the plasma membrane or via endocytosis of the Rim21 sensor protein at the late endosome. We found that the downstream molecules, including arrestin-related protein Rim8, calpain-like protein Rim13, and scaffold protein Rim20, accumulated at the plasma membrane upon external alkalization and that the accumulation was dependent on Rim21. Snf7, an endosomal sorting complex required for transport (ESCRT) III subunit also essential for the Rim101 pathway, localized to the plasma membrane, in addition to the late endosome, under alkaline conditions. Snf7 at the plasma membrane but not at the late endosome was shown to be involved in Rim101 signaling. In addition, the Rim101 pathway was normally activated, even when endocytosis was severely impaired. Considering this information as a whole, we propose that Rim101 signaling proceeds at the plasma membrane. We also found that activity of the Rsp5 ubiquitin ligase was required for recruiting the downstream molecules to the plasma membrane, suggesting that ubiquitination mediates Rim101 signaling at the plasma membrane. PMID:25002535

Obara, Keisuke; Kihara, Akio

2014-09-15

169

Comparison of long-bone radiographs between U.S. Navy divers and matched controls.  

Science.gov (United States)

The long-bone radiographs of a group of nondivers consisting of 177 U.S. Navy enlisted men were compared to the long-bone radiographs of 93 U.S. Navy enlisted divers who were 35 years of age and older. The nondiver control group was matched to the diver group for age, rank, and occupational specialty. Divers were found to have significantly more films classified as positive for aseptic bone necrosis (ABN) and bone cysts than nondivers, while the nondiver group had more films classified as doubtful for ABN than the diver group. The two groups were similar in the number of members classified as having bone islands and sclerotic areas. X-ray classifications by highly experienced radiologists were found to be only moderately reliable. These data indicate that diving as practiced by the U.S. Navy contributes independently to the development of ABN and bone cysts evidenced among divers in this age group. Some caution must be exercised in interpreting these findings, however, because of the larger number of doubtful films found for the nondiver group than for the diver group, the small number of positive and doubtful cases found in either group, the age of the samples used (35 years of age and older), and the substantial degree of unreliability demonstrated in classification of the films. PMID:7123698

Hunter, W L; Biersner, R J

1982-06-01

170

Rim1 modulates direct G-protein regulation of Ca(v)2.2 channels.  

OpenAIRE

Regulation of presynaptic voltage-gated calcium channels is critical for depolarization-evoked neurotransmitter release. Various studies attempted to determine the functional implication of Rim1, a component of the vesicle release machinery. Besides to couple voltage-gated Ca(2+) channels to the presynaptic vesicle release machinery, it was evidenced that Rim1 also prevents voltage-dependent inactivation of the channels through a direct interaction with the ancillary ?-subunits, thus facilit...

Weiss, Norbert; Sandoval, Alejandro; Kyonaka, Shigeki; Felix, Ricardo; Mori, Yasuo; Waard, Michel

2011-01-01

171

Detection of solar wind-produced water in irradiated rims on silicate minerals  

OpenAIRE

Whether water is produced by solar wind (SW) radiolysis has been debated for more than four decades. In this paper, we exploit the high spatial resolution of electron microscopy and sensitivity of valence electron energy-loss spectroscopy to detect water (liquid or vapor) in vesicles within (SW-produced) space-weathered rims on interplanetary dust particle (IDP) surfaces. Water in the rims has implications for the origin of water on airless bodies like the Moon and asteroids, the delivery of ...

Bradley, John P.; Ishii, Hope A.; Gillis-davis, Jeffrey J.; Ciston, James; Nielsen, Michael H.; Bechtel, Hans A.; Martin, Michael C.

2014-01-01

172

Effective sealing of a disk cavity using a double-toothed rim seal  

Science.gov (United States)

The sealing characteristics of an advanced air-cooled turbo-expander disk cavity are examined employing laser sheet flow visualization and static pressure measurements. Tests are conducted on a simplified half-scale model of an actual low pressure turbo-expander first-stage disk cavity. The superior performance of the seal studied is confirmed by comparison with a single-toothed rim seal and a simple axial rim seal.

Bhavnani, S. H.; Khilnani, V. I.; Tsai, L.-C.; Khodadadi, J. M.; Goodling, J. S.; Waggott, J.

1992-06-01

173

Magnetic-Field Amplification in the Thin X-ray Rims of SN1006  

CERN Document Server

Several young supernova remnants (SNRs), including SN1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50 to $100 \\mu$G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic-field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic-field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, $D \\propto E^{\\mu}$. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the full widths at half maximum (FWHM) in terms of energy as FW...

Ressler, Sean M; Reynolds, Stephen P; Long, Knox S; Petre, Robert; Williams, Brian J; Winkler, P Frank

2014-01-01

174

Experimental investigation of the nebular formation of chondrule rims and the formation of chondrite parent bodies  

CERN Document Server

We developed an experimental setup to test the hypothesis that accretionary dust rims around chondrules formed in the solar nebula at elevated temperatures. Our experimental method allows us to form dust rims around chondrule-analogs while being levitated in an inert-gas flow. We used micrometer-sized powdered San Carlos olivine to accrete individual dust particles onto the chondrule-analog at a temperature of 1100{\\deg}C. The resulting dust-rims were analyzed by means of two different techniques: one sample was investigated with non-destructive micro computer tomography, the other with a scanning electron microscope. Both methods give very similar results for the dust-rim structure and a mean dust-rim porosity of 60 percent, demonstrating that both methods are equally well suited for sample analysis. The chondrule-analog's bulk composition has no measurable effect on the accretion efficiency of the dust. We measured the chemical composition of chondrule-analog and dust-rim to check whether elemental exchange...

Beitz, Eike; Mathieu, Romain; Pack, Andreas; Hezel, Dominik C

2011-01-01

175

Rim1 modulates direct G-protein regulation of Ca(v)2.2 channels.  

Science.gov (United States)

Regulation of presynaptic voltage-gated calcium channels is critical for depolarization-evoked neurotransmitter release. Various studies attempted to determine the functional implication of Rim1, a component of the vesicle release machinery. Besides to couple voltage-gated Ca(2+) channels to the presynaptic vesicle release machinery, it was evidenced that Rim1 also prevents voltage-dependent inactivation of the channels through a direct interaction with the ancillary ?-subunits, thus facilitating neurotransmitter release. However, facilitation of synaptic activity may also be caused by a reduction of the inhibitory pathway carried by G-protein-coupled receptors. Here, we explored the functional implication of Rim1 in G-protein regulation of Ca(v)2.2 channels. Activation of ?-opioid receptors expressed in HEK-293 cells along with Ca(v)2.2 channels produced a drastic current inhibition both in control and Rim1-expressing cells. In contrast, Rim1 considerably promoted the extent of current deinhibition following channel activation, favoring sustained Ca(2+) influx under prolonged activity. Our data suggest that Rim1-induced facilitation of neurotransmitter release may come as a consequence of a decrease in the inhibitory pathway carried by G-proteins that contributes, together with the slowing of channel inactivation, to maintain Ca(2+) influx under prolonged activity. The present study also furthers functional insights in the importance of proteins from the presynaptic vesicle complex in the regulation of voltage-gated Ca(2+) channels by G-proteins. PMID:21331761

Weiss, Norbert; Sandoval, Alejandro; Kyonaka, Shigeki; Felix, Ricardo; Mori, Yasuo; De Waard, Michel

2011-04-01

176

Study on thd relationship between serum fibrosis markers levels, bone marrow scintigraphy patterns and clinical staging in patients with chronic ldiopathic myelofibrosis (CIMF)  

International Nuclear Information System (INIS)

Objective: To study the changes of serum fibrosis markers levels and the pattern of bone marrow scintigraphy and their relationship with clinical stages in patients with chronic idiopathic myelofibrosis (CIMF). Methods: Transforming growth factor-?1 (TGF-?1) and platelet derived growth factor (PDGF) (with ELISA), serum typeIII procollagen (PCIII), type IV collagen (C-IV), and laminin (LN) (with RIA) were detected in 46 with patients with chronic idiopathic myelofibrosis and 34 controls. Bone marrow scintigraphy 99m Tc-sulfur colloid was performed in the 46 CIMF patients. Results: Five fibrosis markers in patients with CIMF were significantly higher than those in controls. There were significantly differences among the levels in different stages, especially with sclerotic stage in CIMF patients. The imaging patterns were classified into three types according to the radio-distribution and activity of bone marrow: 13 cases of increased imaging in 14 patients of cellular stage, 17 cases with creased expansion imaging in 19 patients of collagen fiber stage and 13 cases (100%) with totally depressed imaging in patients of sclerotic stage. Conclusion: As the disease progressed, the serum fibrosis markers levels gradually incroased and the scintigraphy patterns corresponded well to the clinical staging. (authors)

177

Determination of component mobilities in bimineralic reaction rims using isotopically doped starting materials  

Science.gov (United States)

Rim growth experiments were performed between monticellite (CaMgSiO4) single crystals and wollastonite (CaSiO3) powder at 900° C and 1.2 GPa to produce bimineralic diopside (CaMgSi2O6) + merwinite (Ca3MgSi2O8) reaction rims. Symmetrical makeup of the internal rim microstructure implies that rims grow from the original interface towards both reactants at identical rates, indicating that solely MgO-diffusion controls overall rim growth with logD (MgO) = -16.3 ± 0.2 m2s-1 (Joachim et al. 2012). Presence of ppm-amounts of water significantly affects the internal rim microstructure. At "very dry" condition, a lamellar microstructure of alternating palisade-shaped diopside and merwinite grains elongated normal to the reaction front is generated, indicating that CaO and SiO2-mobilities are significantly smaller compared to the MgO-mobility. In presence of minute amounts of water a segregated multilayer microstructure with almost perfectly monomineralic merwinite - diopside - merwinite layers oriented parallel to the reaction front develops, indicating a sufficient additional mobility of either CaO or SiO2 compared to MgO. We used isotopically doped wollastonite (44Ca29SiO3) to identify, which component mobility, CaO or SiO2, is enhanced in presence of ppm amounts of water. Both, 44Ca stemming from the wollastonite as well as 40Ca stemming from the monticellite are distributed across the entire rim. In addition to that, small amounts of 40Ca are found within the wollastonite and substantial amounts of 44Ca are found in the monticellite starting material. In contrast to that, 28Si and 29Si remain in the regions that were originally occupied by their respective source materials monticellite and wollastonite, indicating that the SiO2-mobility is comparatively low. This suggests that the presence of small amounts of water significantly enhances the relative mobility of CaO. Consequently minute amounts of water may not only affect overall rim growth kinetics but also the relative component mobilities and accordingly the internal rim organization. B. Joachim, E. Gardés, B. Velickov, R. Abart, W. Heinrich (2012) Experimental growth of diopside + merwinite reaction rims: the effect of water on microstructure development. Am Min 97, pp. 220-230.

Joachim, Bastian; Abart, Rainer; Höschen, Carmen; Heinrich, Wilhelm

2013-04-01

178

Bone cancer.  

Science.gov (United States)

Primary bone cancers are extremely rare neoplasms, accounting for fewer than 0.2% of all cancers. The evaluation and treatment of patients with bone cancers requires a multidisciplinary team of physicians, including musculoskeletal, medical, and radiation oncologists, and surgeons and radiologists with demonstrated expertise in the management of these tumors. Long-term surveillance and follow-up are necessary for the management of treatment late effects related to surgery, radiation therapy, and chemotherapy. These guidelines discuss the management of chordoma, giant cell tumor of the bone, and osteosarcoma. PMID:23744868

Biermann, J Sybil; Adkins, Douglas R; Agulnik, Mark; Benjamin, Robert S; Brigman, Brian; Butrynski, James E; Cheong, David; Chow, Warren; Curry, William T; Frassica, Deborah A; Frassica, Frank J; Hande, Kenneth R; Hornicek, Francis J; Jones, Robin L; Mayerson, Joel; McGarry, Sean V; McGrath, Brian; Morris, Carol D; O'Donnell, Richard J; Randall, R Lor; Santana, Victor M; Satcher, Robert L; Siegel, Herrick J; von Mehren, Margaret; Bergman, Mary Anne; Sundar, Hema

2013-06-01

179

Bone Identification  

Science.gov (United States)

This activity (page 3 of the PDF) is a full inquiry investigation into fossil hunting and identification. Groups of learners will sift through a commercially prepared owl pellet, looking for bone pieces that they will attempt to match to an identification chart and subsequently arrange into a rough skeleton. Learners use this exercise to consider how animal skeletons help researchers determine what kinds of animals live together in an ecosystem as well compare the bones they find to the bones in their own body. Relates to linked video, DragonflyTV GPS: Dinosaurs.

Twin Cities Public Television, Inc.

2006-01-01

180

Spinal metastatic lesion in cancer patients. Investigation based on statistical analysis by bone scintigrams  

International Nuclear Information System (INIS)

In a series of 2,216 cancer patients undergoing bone scintigraphy after diagnosis of the primary malignant tumor, 558 (25.2%) were found to have abnormal vertebral accumulation of radioactivity during the clinical course. Abnormal radioactivity in the vertebrae was frequently noted in patients with prostatic and renal cancer. The lumbar vertebrae were the most frequent sites but the cervical vertebrae were also affected with prostatic cancer, the thoracic vertebrae with lung and prostatic cancer, the lumbar vertebrae with breast and prostatic cancer and the sacral vertebrae with uterine cervical and prostatic cancer. Of the 558 patients with abnormal spinal radioactivity, 221 were examined by CT scan; the accumulated radioactivity was identified as a metastatic lesion in 170 patients (76.9%). Abnormal radioactivity was identified as a metastatic lesion most often in lung cancer patients. The CT-diagnosed metastases were classified into 3 types: sclerotic (51 patients, 30.0%), osteolytic (112, 65.9%), and mixed (46, 27.1%). The sclerotic type was relatively frequent in uterine cervical cancer, less frequent in lung cancer, and not seen in head and neck or renal cancer patients. The osteolytic type was relatively frequent in lung and renal cancer and less frequent in uterine cervical and prostatic cancer patients. Of the patients with CT-diagnosed vertebral metastasis, 87.3% survived for 3 months and 66.2% for 6 months after the detection of abnormal bone scintigraphy. detection of abnormal bone scintigraphy. Survival was shorter in patients with lung or gastrointestinal cancer than in those with other types of tumors. Since the pathology of vertebral metastasis of malignant tumors differs according to the primary lesion, the metastatic nature must be considered in the choice of treatment. (author)

181

Bone Density  

Science.gov (United States)

... there are things you can do to help slow down bone loss. These include eating foods rich in calcium and vitamin D and doing weight-bearing exercise such as walking, bowling or dancing. In some cases, your doctor ...

182

Bone Tumor  

Science.gov (United States)

... Non-ossifying ? bromaunicameral (simple) bone cyst • Osteochondroma • Giant cell tumor .org Page ( 2 ) AAOS does not endorse any ... taken for other reasons, such as a sprained ankle or rotator cu? problem. Doctor Examination If you ...

183

Three-dimensional microstructural analysis of human lumber vertebrae using microcomputed tomography in bone metastasis from prostate cancer  

International Nuclear Information System (INIS)

Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. However, the morphological details of bone metastasis of prostate cancer have not been clarified. The trabecular bone structure of bone metastasis from prostate cancer was investigated in three dimensions using microcomputed tomography (micro-CT). A total of 17 cubes of the lumber spine of a 77-year-old man with prostate cancer were excised post mortem: four of them from non-metastatic and the rest from metastatic sites. The samples were measured using micro-CT with a resolution of 23.2 ?m and the standard structural indices and degree of anisotropy were computed. After micro-CT measurement, the samples were tested in a destructive manner for the assessment of mechanical properties. Samples from the metastatic sites showed significantly higher values than those from non-metastatic sites for bone volume (BV), bone surface (BS), bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N) (p<0.005). Bone surface density (BS/BV) and trabecular separation (Tb.Sp) were significantly higher in the samples from non-metastatic sites (p<0.001). Samples from metastatic sites showed a more isotropic arrangement of trabecular bone than those from non-metastatic sites. Three-dimensionally reconstructed images depicted several different patterns of sclerotic bone metastasis, and osteolytic appearance was observed in all of them. Structural parameters such as BV/TV were weluctural parameters such as BV/TV were well correlated with the mechanical properties (r=0.899). The present study clarified the trabecular microstructure of bone metastasis from prostate cancer and suggests that both osteolysis and osteogenesis progress while interacting with each other in all phases of bone metastasis. (author)

184

Three-dimensional microstructural analysis of human lumber vertebrae using microcomputed tomography in bone metastasis from prostate cancer  

Energy Technology Data Exchange (ETDEWEB)

Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. However, the morphological details of bone metastasis of prostate cancer have not been clarified. The trabecular bone structure of bone metastasis from prostate cancer was investigated in three dimensions using microcomputed tomography (micro-CT). A total of 17 cubes of the lumber spine of a 77-year-old man with prostate cancer were excised post mortem: four of them from non-metastatic and the rest from metastatic sites. The samples were measured using micro-CT with a resolution of 23.2 {mu}m and the standard structural indices and degree of anisotropy were computed. After micro-CT measurement, the samples were tested in a destructive manner for the assessment of mechanical properties. Samples from the metastatic sites showed significantly higher values than those from non-metastatic sites for bone volume (BV), bone surface (BS), bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N) (p<0.005). Bone surface density (BS/BV) and trabecular separation (Tb.Sp) were significantly higher in the samples from non-metastatic sites (p<0.001). Samples from metastatic sites showed a more isotropic arrangement of trabecular bone than those from non-metastatic sites. Three-dimensionally reconstructed images depicted several different patterns of sclerotic bone metastasis, and osteolytic appearance was observed in all of them. Structural parameters such as BV/TV were well correlated with the mechanical properties (r=0.899). The present study clarified the trabecular microstructure of bone metastasis from prostate cancer and suggests that both osteolysis and osteogenesis progress while interacting with each other in all phases of bone metastasis. (author)

Tamada, Tsutomu [Kawasaki Medical School, Kurashiki, Okayama (Japan)

2000-11-01

185

Disorders of Bone Remodeling  

OpenAIRE

The skeleton provides mechanical support for stature and locomotion, protects vital organs, and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone modeling to carry out these crucial functions throughout life. Bone remodeling involves the removal of old or damaged bone by osteoclasts (bone resorption) and the subsequent replacement of new bone formed by osteoblasts (bone formation). Normal bone remodeling requires a tight coupling of bone resorption to bone f...

Feng, Xu; Mcdonald, Jay M.

2011-01-01

186

Mechanical fracture study of nuclear fuel high burn-up structure (HBS or RIM) during annealing test; Etude de la fracturation mecanique de la structure a haut taux de combustion des combustibles irradies (RIM) en traitement thermique  

Energy Technology Data Exchange (ETDEWEB)

The ceramics used in Power Water Reactors ar made of uranium dioxide. Irradiated at high Burn-up, they present a characteristic zone in periphery called High Burn-Up Structure or RIM zone with micrometer pores containing over-pressurized gas bubbles. Annealing texts simulating incidental or accidental reactor situations, a strong release of the RIM zone is observed. We have considered that the fission gas release mechanism is the mechanical fracture of the RIM grain boundaries. The we have compared the different types of mechanical stress applied to a grain boundary with the fracture stress of the oxide. The first stress is due to RIM over-pressurized gas bubbles, these bubbles apply a stress field determined at a microscopic level i.e. at the gas bubbles scale and its local environment. The second stress is generated by the Pellet-Cladding Mechanical Interaction (PCMI). This stress applies a stress field on a microscopic scale i.e. at the RIM zone and its overall environment. The last stress is occurred by a strain due to the RIM structural evolution during annealing test. The experimental results show that microscopic and macroscopic stress fields to do not explain the RIM grain boundary fracture during annealing test. The stresses induced by the RIM structural evolution as a function of the temperature is a possible mechanism to explain the overall mechanical behavior of the RIM zone during annealing test. (author)

Marcet, M.

2010-12-07

187

Hypoechoic rim of chronically inflamed prostate, as seen at TRUS: histopathologic findings  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study is to correlate the findings of peripheral hypoechoic rim, seen at transrectal ultrasonography (TRUS) in chronic prostatitis patients, with the histopthologic findings. Seven patients with pathologically proven chronic prostatitis were involved in this study. The conspicuity of the peripheral hypoechoic prostatic rim, seen at TRUS, was prominent and subtle, and to determine its histopathologic nature, the microscopic findings were reviewed. In five of seven cases (71%), TRUS demonstrated a prominent peripheral hypoechoic rim. Microscopic examination revealed that inflammatory cell infiltration of prostatic glandular tissue was severe in three cases (42.9%), moderate in two (28.6%), and minimal in two (28.6%). In all seven cases, the common histopathologic findings of peripheral hypoechoic rim on TRUS were loose stromal tissues, few prostatic glands, and sparse infiltration by inflammatory cells. The peripheral hypoechoic rim accompanying prostatic inflammation and revealed by TRUS reflects a sparsity of prostate glandular tissue and is thought to be an area in which inflammatory cell infiltration is minimal.

Lee, Hak Jong [Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Choe, Ghee Young; Kim, Seung Hyup [Seoul National University College of Medicine, Seoul (Korea, Republic of); Seong, Chang Gyu [Kyungpook National University College of Medicine, Taegu (Korea, Republic of)

2001-09-01

188

Hypoechoic rim of chronically inflamed prostate, as seen at TRUS: histopathologic findings  

International Nuclear Information System (INIS)

The purpose of this study is to correlate the findings of peripheral hypoechoic rim, seen at transrectal ultrasonography (TRUS) in chronic prostatitis patients, with the histopthologic findings. Seven patients with pathologically proven chronic prostatitis were involved in this study. The conspicuity of the peripheral hypoechoic prostatic rim, seen at TRUS, was prominent and subtle, and to determine its histopathologic nature, the microscopic findings were reviewed. In five of seven cases (71%), TRUS demonstrated a prominent peripheral hypoechoic rim. Microscopic examination revealed that inflammatory cell infiltration of prostatic glandular tissue was severe in three cases (42.9%), moderate in two (28.6%), and minimal in two (28.6%). In all seven cases, the common histopathologic findings of peripheral hypoechoic rim on TRUS were loose stromal tissues, few prostatic glands, and sparse infiltration by inflammatory cells. The peripheral hypoechoic rim accompanying prostatic inflammation and revealed by TRUS reflects a sparsity of prostate glandular tissue and is thought to be an area in which inflammatory cell infiltration is minimal

189

Mechanical fracture study of nuclear fuel high burn-up structure (HBS or RIM) during annealing test  

International Nuclear Information System (INIS)

The ceramics used in Power Water Reactors ar made of uranium dioxide. Irradiated at high Burn-up, they present a characteristic zone in periphery called High Burn-Up Structure or RIM zone with micrometer pores containing over-pressurized gas bubbles. Annealing texts simulating incidental or accidental reactor situations, a strong release of the RIM zone is observed. We have considered that the fission gas release mechanism is the mechanical fracture of the RIM grain boundaries. The we have compared the different types of mechanical stress applied to a grain boundary with the fracture stress of the oxide. The first stress is due to RIM over-pressurized gas bubbles, these bubbles apply a stress field determined at a microscopic level i.e. at the gas bubbles scale and its local environment. The second stress is generated by the Pellet-Cladding Mechanical Interaction (PCMI). This stress applies a stress field on a microscopic scale i.e. at the RIM zone and its overall environment. The last stress is occurred by a strain due to the RIM structural evolution during annealing test. The experimental results show that microscopic and macroscopic stress fields to do not explain the RIM grain boundary fracture during annealing test. The stresses induced by the RIM structural evolution as a function of the temperature is a possible mechanism to explain the overall mechanical behavior of the RIM zone during annealing test. (author)

190

Development of phased array UT technique for inspection of turbine wheel rim  

International Nuclear Information System (INIS)

A phased array UT technique has been developed for the improvement of defect detection under the keyway region of shrunk-on type turbine wheel. The sector scanning mode operation with plexiglas wedge of phased array capability was applied to construct the B-scope image of turbine wheel rim region. Preceding to the inspection test of the model specimen having real shape of rim region, the distribution of sound field intensity along the steering angle of the scanning line was measured on the test block. Then, the minimum depth of detectable defect by the B-scope imaging was evaluated on the dovetail shape specimens which had different depth EDM notches at the each hook fillet. As the results, it has been realized that the B-scope imaging of the sector scanning mode phased array technique has a capability for distinguishing the defect echoes from the many reflection echoes caused by the complexed shape of wheel rim region

191

A FIB/TEM Study of a Complex Wark-Lovering Rim on a Vigarano CAI  

Science.gov (United States)

Wark-Lovering (WL) rims are thin multilayered mineral sequences that surround most Ca, Al-rich inclusions (CAIs). Several processes have been proposed for WL rim formation, including condensation, flash-heating or reaction with a nebular reservoir, or combinations of these [e.g. 1-7], but no consensus exists. Our previous coordinated transmission electron microscope (TEM) and NanoSIMS O isotopic measurements showed that a WL rim experienced flash heating events in a nebular environment with planetary O isotopic composition, distinct from the (16)O-rich formation environment [6]. Our efforts have focused on CAIs from the CV(sub red) chondrites, especially Vigarano, because these have escaped much of the parent body alteration effects that are common in CAIs from CV(sub ox) group.

Keller, L. P.; Needham, A. W.; Messenger, S.

2013-01-01

192

Cracking of an Aircraft Wheel Rim Made From Al-Alloy 2014-T6  

Directory of Open Access Journals (Sweden)

Full Text Available Generally failures of different aircraft components and parts are revealed and examined by the use of non-destructive examination methods. In further detailed explanation and interpretation of failures optical and scanning electron microscopy are used. This paper deals with a problem of a crack on aircraft wheel rim made from aluminium alloy 2014-T6.The crack was observed during regular control by the maintenance unit for non-destructive examination of the Slovenian air carrier Adria Airways. The crack on the rim of an aircraft wheel investigated was a typical fatigue crack. At same time a numerous pits were found which served as stress concentrations on the rim surface.

G. Kosec

2010-10-01

193

A sign-reversing involution for rooted special rim-hook tableaux  

OpenAIRE

Egecioglu and Remmel gave an interpretation for the entries of the inverse Kostka matrix K^{-1} in terms of special rim-hook tableaux. They were able to use this interpretation to give a combinatorial proof that KK^{-1}=I but were unable to do the same for the equation K^{-1}K=I. We define a sign-reversing involution on rooted special rim-hook tableaux which can be used to prove that the last column of this second product is correct. In addition, following a suggestion of Ch...

Sagan, Bruce E.; Lee, Jaejin

2003-01-01

194

Search for triggered star formation in the type A bright rimmed cloud 34  

Science.gov (United States)

Bright rimmed clouds (BRCs) near OB stars are excellent laboratories for the study of triggered star formation (TSF) due to the radiation driven implosion (RDI) mechanism. Type A BRCs are clouds at their earliest evolutionary stages and, according to the current theoretical modeling, are not expected to exhibit RDI TSF yet. Employing the Chandra's ability to effectively discern young stellar populations from unrelated old field objects we propose to observe the nearby Type A bright rimmed cloud BRC 34 and test predictions of RDI modelling. BRC 34 will also complement our large GO project on BRCs with the aim to study the RDI star formation efficiency in the Galaxy.

Garmire, Gordon

2008-09-01

195

Nonimaging secondary concentrators for large rim angle parabolic troughs with tubular absorbers.  

Science.gov (United States)

For parabolic trough solar collectors with tubular absorbers, we design new tailored secondary concentrators. The design is applicable for any rim angle of a parabolic reflector. With the secondary, the concentration can be increased by a factor of more than 2 with a compact secondary reflector consisting of a single piece, even for the important case of a rim angle of 90 deg. The parabolic reflector can be used without changes; the reduced absorber is still tubular but smaller than the original absorber and slightly displaced toward the primary. PMID:21085359

Ries, H; Spirkl, W

1996-05-01

196

Organization of lower rim O-alkylated p-phosphonic acid calix[4]arenes  

OpenAIRE

Lower rim O-methyl, -n-butyl, and n-octadecyl calix[4]arenes bearing p-phosphonic acid groups on the upper rim have been prepared in high yield, compounds 12-14. Where possible the compounds have been characterized in the solid state using X-ray diffraction, or as the precursor phosphate esters or a cesium salt. The cone conformation ethyl phosphate ester for the octadecyl compound crystallizes in a bi-layer 39.1 Å thick which approaches the 40 Å of biological membranes. The 1,3-alternate c...

Clark, Thomas E.; Makha, Mohamed; Sobolev, Alexandre N.; Su, Dian; Rohrs, Henry; Gross, Michael L.; Raston, Colin L.

2009-01-01

197

Bone Marrow Diseases  

Science.gov (United States)

Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. ... help with blood clotting. If you have a bone marrow disease, there are problems with the stem cells ...

198

Bone Marrow Transplantation  

Science.gov (United States)

Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. ... platelets, which help the blood to clot. A bone marrow transplant is a procedure that replaces a person's ...

199

Bone Graft Alternatives  

Science.gov (United States)

... deformity or during a surgical procedure such as spinal fusion. What Types of Bone Grafts are There? Bone ... of bone grafts in spine surgery is during spinal fusion. The use of autogenous bone grafts for spinal ...

200

Proximal Tibial Bone Graft  

Science.gov (United States)

... Treatments of the Smaller Toes AOFAS / FootCareMD / Treatments Proximal Tibial Bone Graft Page Content What is a ... bone from the proximal tibia. What is a proximal tibial bone graft? Proximal tibial bone graft (PTBG) ...

201

[Bone transplant].  

Science.gov (United States)

We describe the methodology of the Bone and Soft Tissue Bank, from extraction and storage until use. Since the year 1986, with the creation of the Bone Bank in the University Clinic of Navarra, more than 3,000 grafts have been used for very different types of surgery. Bone grafts can be classified into cortical and spongy; the former are principally used in surgery to save tumour patients, in large post-traumatic reconstructions and in replacement surgery where there are massive bone defects and a structural support is required. The spongy grafts are the most used due to their numerous indications; they are especially useful in filling cavities that require a significant quantity of graft when the autograft is insufficient, or as a complement. They are also of special help in treating fractures when there is bone loss and in the treatment of delays in consolidation and pseudoarthrosis in little vascularized and atrophic zones. They are also used in prosthetic surgery against the presence of cavity type defects. Allografts of soft tissues are specially recognised in multiple ligament injuries that require reconstructions. Nowadays, the most utilised are those employed in surgery of the anterior cruciate ligament although they can be used for filling any ligament or tendon defect. The principal difficulties of the cortical allografts are in the consolidation of the ends with the bone itself and in tumour surgery, given that these are patients immunodepressed by the treatment, the incidence of infection is increased with respect to spongy grafts and soft tissues, which is irrelevant. In short, the increasingly widespread use of allografts is an essential therapeutic weapon in orthopaedic surgery and traumatology. It must be used by expert hands. PMID:16998521

San Julián, M; Valentí, A

2006-01-01

202

Bone Stress  

Science.gov (United States)

In this optics activity, learners examine how polarized light can reveal stress patterns in clear plastic. Learners place a fork between two pieces of polarizing material and induce stress by squeezing the tines together. Learners will observe the colored stress pattern in the image of the plastic that is projected onto a screen using an overhead projector. Learners rotate one of the polarizing filters to explore which orientations give the most dramatic color effects. This activity can be related to bones, as bones develop stress patterns from the loads imposed upon them every day.

Exploratorium, The

2011-12-07

203

Pigmented villonodular synovitis of the joints: Radiological features of bone involvement  

Energy Technology Data Exchange (ETDEWEB)

Pigmented villonodular synovitis (PVNS) of the joints is rare, benign and generally monoarticular tumour-like soft tissue lesion of the synovium. The secondary bone changes, seen in plain films of 25 patients with PVNS are described. The main radiological features were paraarticular erosions, often with a thin sclerotic border. As a late manifestation these erosions tended to coalesce and to form large multicystic areas. These defects were observed particularly in the more tightly encapsulated joints such as the hip, wrist, finger and toe. In 3 cases with involvement of the knee the lesions were monostotic. PVNS may be mistaken radiologically for other lesions such as malignant tumours or inflammatory disorders. The differential diagnosis is discussed.

Bohndorf, K.; Stoker, D.J.

1987-07-01

204

Pigmented villonodular synovitis of the joints: Radiological features of bone involvement  

International Nuclear Information System (INIS)

Pigmented villonodular synovitis (PVNS) of the joints is rare, benign and generally monoarticular tumour-like soft tissue lesion of the synovium. The secondary bone changes, seen in plain films of 25 patients with PVNS are described. The main radiological features were paraarticular erosions, often with a thin sclerotic border. As a late manifestation these erosions tended to coalesce and to form large multicystic areas. These defects were observed particularly in the more tightly encapsulated joints such as the hip, wrist, finger and toe. In 3 cases with involvement of the knee the lesions were monostotic. PVNS may be mistaken radiologically for other lesions such as malignant tumours or inflammatory disorders. The differential diagnosis is discussed. (orig.)

205

Bone: From planar imaging to SPECT & PET/CT  

Directory of Open Access Journals (Sweden)

Full Text Available Since its introduction into clinical medicine 50 years ago, the radionuclide bone scan has played a key role in diagnosing a variety of osseous disorders; particularly metastatic disease. Using small diagnostic doses of Strontium-85 in the 1960’s, it was rapidly established that the study was much more sensitive than skeletal radiographs. The introduction of Technetium-99m phosphate agents in the early 1970’s, offered greatly improved resolution. Whole body imaging became the standard procedure. Interestingly, the positron-emitter, Fluorine 18-sodium fluoride was used by some investigators with the rectilinear scanner. Very recently, this radiotracer has been re-introduced and is witnessing considerable growth using modern PET/CT instrumentation. The cortical bone tracers, 99mTc-MDP and 18F-Fluoride assess osteoblastic response to the invading lesion. In the study of metastatic disease, it is superb for sclerotic blastic lesions. Although it detects most lytic lesions, many can be missed. This is due to a lack of osteoblastic response. The tumor may be slow growing, such as myeloma or conversely very rapidly growing and destructive, such as lung or kidney metastases. In these lesions, 18F-FDG is superior because it is concentrating in the tumor cells and does not depend on osteoblastic response to the tumor. In their early cause, many lytic lesions may be confined to the medullary portion of bone and not yet involve the cortex. Comparative studies of PET and CT have clearly shown the superior sensitivity of FDG in detecting metastatic bone lesions.

Mihailovi? Jasna

2012-01-01

206

Eosinophilic granuloma of the temporal bone in children.  

Science.gov (United States)

Eosinophilic granuloma (EG) is a bony destructive disease that frequently occurs in children; it is a subtype of Langerhans cell histiocytosis. The aims of this study were to detect the presenting features of temporal bone lesions in children and to evaluate the efficacy of surgery combined with radiotherapy in treatment of the disease. A retrospective study on 12 children with EG of the temporal bone was done. Computed tomography and hearing assessment were performed for all patients. All patients were treated with cortical mastoidectomy followed by postoperative radiotherapy. Follow-up was carried out for at least 2 years. The patients' presenting symptoms were external ear canal mass in 10 patients (83.3%), postauricular swelling in 8 patients (66.7%), and persistent otorrhea in 4 patients (33.3%). Ten patients (83.3%) showed conductive hearing loss, whereas 2 patients (16.7%) showed mixed hearing loss on the affected side. Computed tomography showed osteolytic defects without sclerotic margins filled with soft tissue masses involving the mastoid bone. Histopathologic examination showed eosinophils and Langerhans cells that were immune reactive for CD1 antigen and S-100 protein. Postoperative follow-up showed complete cure of the disease in 10 children (83.3%), with recurrence detected in 2 patients (16.7%) who needed second surgical intervention. We concluded that temporal bone EG in children may present with features that mimic the features of chronic suppurative otitis media. However, computed tomography and histopathologic examination are diagnostic. Cortical mastoidectomy together with postoperative radiotherapy is an achievable treatment in most cases. PMID:24717312

Abdel-Aziz, Mosaad; Rashed, Mohammed; Khalifa, Badawi; Talaat, Ahmed; Nassar, Ahmed

2014-05-01

207

Bone lesion biopsy  

Science.gov (United States)

A bone lesion biopsy is the removal of a piece of bone or bone marrow for examination. ... The most common reasons for bone lesion biopsy are to tell the difference between cancerous and noncancerous bone tumors and to identify other bone problems. It may be ...

208

Broken bone  

Science.gov (United States)

... DO NOT move the person if a head, neck, or back injury is suspected. CHECK BLOOD CIRCULATION Check the person's ... is a suspected broken bone in the head, neck, or back. There is a ... immobilize the injury at the scene by yourself. There is severe ...

209

Bone scintiscanning  

International Nuclear Information System (INIS)

The authors present in detail the foundations and techniques of bone scintigraphy. Scintigraphic semiology in joint diseases is considered in full. Finally the limits and indications of this technique, which concerns many branches: rheumatology, cancerology, hematology, nephrology, traumatology, orthopedics, are outlined

210

Bone scans  

International Nuclear Information System (INIS)

Oftentimes, in managing podiatric complaints, clinical and conventional radiographic techniques are insufficient in determining a patient's problem. This is especially true in the early stages of bone infection. Bone scanning or imaging can provide additional information in the diagnosis of the disorder. However, bone scans are not specific and must be correlated with clinical, radiographic, and laboratory evaluation. In other words, bone scanning does not provide the diagnosis but is an important bit of information aiding in the process of diagnosis. The more useful radionuclides in skeletal imaging are technetium phosphate complexes and gallium citrate. These compounds are administered intravenously and are detected at specific time intervals postinjection by a rectilinear scanner with minification is used and the entire skeleton can be imaged from head to toe. Minification allows visualization of the entire skeleton in a single image. A gamma camera can concentrate on an isolated area. However, it requires multiple views to complete the whole skeletal image. Recent advances have allowed computer augmentation of the data received from radionucleotide imaging. The purpose of this chapter is to present the current radionuclides clinically useful in podiatric patients

211

Bone Densitometry  

Medline Plus

Full Text Available ... special device. Bone Densitometry Machine Most machines use x-rays but some use ultrasound. A densitometry machine can ... is very safe. However, the machines that use x-rays should not be used on pregnant women. This ...

212

Dem Bones  

Science.gov (United States)

In this case, students enter the world of a forensic anthropologist who must determine the sex and age of an individual from a collection of bones. Students, in turn, simulate some of the actual procedures conducted in a forensic anthropologist's lab, exa

Alease Bruce

2001-09-01

213

Stereological evolution of the rim structure in PWR-fuels at prolonged irradiation: Dependencies with burn-up and temperature  

International Nuclear Information System (INIS)

The stereology of the rim-structure was studied for PWR-fuels up to the ninth irradiation cycle, achieving maximum local burn-ups of 240 GWd/tM and beyond. At intermediate radial positions (0.55 0 c = 0.29. Rim-cavities are expected to remain closed at least up to this limit

214

76 FR 69720 - NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...  

Science.gov (United States)

...Commission [ Docket No. ER12-295-000] NaturEner Rim Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based...the above-referenced proceeding of NaturEner Rim Rock Wind Energy, LLC's application for market-based rate...

2011-11-09

215

49 CFR 571.110 - Tire selection and rims and motor home/recreation vehicle trailer load carrying capacity...  

Science.gov (United States)

...2010-10-01 2010-10-01 false Tire selection and rims and motor home...Vehicle Safety Standards § 571.110 Tire selection and rims and motor home...This standard specifies requirements for tire selection to prevent tire...

2010-10-01

216

Rim15p-mediated regulation of sucrose utilization during molasses fermentation using Saccharomyces cerevisiae strain PE-2.  

Science.gov (United States)

Inherited loss-of-function mutations in the Rim15p-mediated stress-response pathway contribute to the high fermentation rate of sake yeast strains. In the present study, we found that disruption of the RIM15 gene in ethanol-producing Saccharomyces cerevisiae strain PE-2 accelerated molasses fermentation through enhanced sucrose utilization following glucose starvation. PMID:23757382

Inai, Tomomi; Watanabe, Daisuke; Zhou, Yan; Fukada, Rie; Akao, Takeshi; Shima, Jun; Takagi, Hiroshi; Shimoi, Hitoshi

2013-11-01

217

Pinhole bone scan mapping of metabolic profiles in osteoarthritis of the knee: a radiographic correlation  

International Nuclear Information System (INIS)

Osteoarthritis (OA) is mixture of damage to a joint and reaction induced therefrom. Heterogeneity, slow change and no proper means of assessing pathology make it a difficult disease to study. Diagnosis can be made by radiography when OA is established. But subtle metabolic change without radiographic alteration can only be detected by bone scan. Present study was performed to assess metabolic profiles of OA of the knee with various radiographic and preradiographic changes using pinhole bone scan (PBS). PBS and radiography were taken at the same time or a few days apart. We used single-head gamma camera and a 4-mm pinhole collimator. Patients were 9 men and 19 women (30-74 yr with mean being 55). PBS was correlated with radiography in each case. Increased tracer uptake was seen in 111 lesions in 28 knees. Intensity was arbitrarily graded into Grade 0-2. The results were divided into group with radiographic change (n=85; Table) and group without (n=26). Generally, tracer uptake was much intense in the sclerotic and cystic form. In radiographically normal group pathological uptake occurred mostly in subchondral bone (n=17) and some in the femoral condyle (n=9) denoting that subchondral bone is the most vulnerable. PBS is sensitive indicator of metabolic alternations in various disease processes of OA in both radiographically normal and abnormal cases

218

Single stage reconstruction of alar rim defect using auricular composite graft: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available A case report of reconstruction of a post infective alar rim defect, in a girl of 13 years of age, occurring as a result of septic piercing of the nose, using a composite graft taken from the ear in a single stage is described.

Soni A

2005-01-01

219

A rare complication during percutaneous transcatheter closure of atrial septal defect: Atrial rim erosion  

Directory of Open Access Journals (Sweden)

Full Text Available In this report we persent a rare complication of Amplatzer septal occluder; associated with ‘atrial rim’ erosion during atrial septal defect closure. In our case report, we also present a brief review of literature of complications associated with transcatheter closure of atrial septal defects

Mehmet Erdem Memeto?lu

2011-06-01

220

Incident laser modulation of a repaired damage site with a rim in fused silica rear subsurface  

International Nuclear Information System (INIS)

Local CO2 laser treatment has proved to be an effective method to prevent the 351-nm laser-induced damage sites in a fused silica surface from exponentially growing, which is responsible for limiting the lifetime of optics in high fluence laser systems. However, the CO2 laser induced ablation crater is often surrounded by a raised rim at the edge, which can also result in the intensification of transmitted ultraviolet light that may damage the downstream optics. In this work, the three-dimensional finite-difference time-domain method is developed to simulate the distribution of electrical field intensity in the vicinity of the CO2 laser mitigated damage site located in the exit subsurface of fused silica. The simulated results show that the repaired damage sites with raised rims cause more notable modulation to the incident laser than those without rims. Specifically, we present a theoretical model of using dimpled patterning to control the rim structure around the edge of repaired damage sites to avoid damage to downstream optics. The calculated results accord well with previous experimental results and the underlying physical mechanism is analysed in detail. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

221

Study on High Sensitive FFDL Technique for Monju and next generation SFR Using RIMS  

International Nuclear Information System (INIS)

The high sensitive Failed Fuel Detection and Location technique for fast reactors has been developed using RIMS. Major achievements: - Tag gas (krypton and Xenon) was successfully identified with no concentration process in Joyo. - Burn-up of the failed fuel subassembly can be assumed. - Prototype FFDL system for Monju was proposed. ? Further enhancement of fast reactor safety

222

The kinetics of dolomite reaction rim growth under isostatic and non-isostatic pressure conditions  

Science.gov (United States)

During burial and exhumation, rocks are simultaneously exposed to metamorphic reactions and tectonic stresses. Therefore, the reaction rate of newly formed minerals may depend on chemical and mechanical driving forces. Here, we investigate the reaction kinetics of dolomite (CaMg[CO3]2) rim growth by solid-state reactions experiments on oriented calcite (CaCO3) and magnesite (MgCO3) single crystals under isostatic and non-isostatic pressure conditions. Cylindrical samples of 3-5 mm length and 7 mm diameter were drilled and polished perpendicular to the rhombohedral cleavage planes of natural clear crystals. The tests were performed using a Paterson-type deformation apparatus at P = 400 MPa confining pressure, temperatures, T, between 750 and 850°C, and reaction durations, t, of 2 - 146 h to calculate the kinetic parameters of dolomite rim growth under isostatic stress conditions. For non-isostatic reaction experiments we applied in addition differential stresses, ?, up to 40 MPa perpendicular to the contact interface at T = 750°C for 4 - 171 h duration, initiating minor inelastic deformation of calcite. The thickness of the resulting dolomite reaction rims increases linearly with the square root of time, indicating a diffusion-controlled reaction. The rims consist of two different textural domains. Granular dolomite grains (? 2 -5 ?m grain size) form next to calcite and elongated palisade-shaped grains (1-6 ?m diameter) grow perpendicular to the magnesite interface. Texture measurements with the electron backscatter diffraction technique indicate that the orientations of dolomite grains are mainly influenced by the orientation of the calcite educt crystal, in particular in the granular rim. To some extent, the texture of dolomite palisades is also influenced by the orientation of magnesite. The thickness of the two individual layers increases with temperature. At 400 MPa isostatic pressure, T = 750°C and t = 29 hours, a 5 ?m thick granular dolomite layer and a 7 ?m thick palisade-shaped layer evolve. At similar conditions and a differential stress of 30 MPa, the rim thickness remains similar; consequently the effect of non-isostatic stress on dolomite rim growth is negligible. Platinum markers show that the initial calcite-magnesite interface is located between granular and palisade-forming dolomite, indicating that rim growth occurs by counter diffusion of MgO and CaO. Diffusion of MgO across the dolomite reaction rim into calcite forms additionally magnesio-calcite grains with diameters of ? 13 - 46 ?m, depending on the experimental conditions and increasing with increasing distance to the dolomite boundary. At T = 750°C, t = 29 hours, the thickness of the magnesio-calcite layer is 32 ?m (isostatic) - 35 ?m (? = 30 MPa). The experiments indicate that solid-state reaction rim growth of dolomite between calcite and magnesite is primarily controlled by diffusion of MgO and CaO, forming layers with different microstructures during growth into the educt phases. The kinetics of the reaction in the carbonate system are not significantly changed by differential stresses up to 40 MPa. We suggest that volume diffusion is the dominant transport mechanism, which is presumably less affected by non-isostatic stresses than grain boundary diffusion.

Helpa, V.; Rybacki, E.; Morales, L. G.; Abart, R.; Dresen, G. H.

2013-12-01

223

Diffusion-controlled growth of bimineralic merwinite - diopside reaction rims between wollastonite - monticellite interfaces  

Science.gov (United States)

At temperatures of 800 °C to 900 °C and 1.2 GPa, monticellite and wollastonite react to form merwinite and diopside after the reaction: 2 monticellite (CaMgSiO4) + 2 wollastonite (CaSiO3) â?? merwinite (Ca3MgSi2O8) + diopside (CaMgSi2O6) We synthesized bimineralic merwinite - diopside reaction rims along the interfaces of cylindric crystals of monticellite and wollastonite. The samples were loaded in a platinum capsule and annealed at 800 °C to 900 °C and 1.2 GPa in a piston cylinder apparatus for 5 to 65 hours. Natural CaF2 was used as pressure medium and the charges were nominally dry. In all experiments, a single layer consisting of bimineralic aggregates of merwinite and diopside was produced in about equal molar amounts. Time series revealed that rim growth is parabolic, indicating that the reaction kinetics is controlled by component diffusion. SEM analysis of the microstructure showed that the original monticellite-wollastonite interface is located in the centre of the reaction rim. This implies that rim growth primarily occurred by transfer of the mobile component MgO from the rim-monticellite interface to the rim-wollastonite interface. The bulk reaction is thus divided into two half reactions occurring at the two reaction fronts. At the rim-monticellite interface the reaction is: 2 monticellite â?? 0.5 merwinite + 0.5 diopside + MgO, and at the rim-wollastonite interface, it is: 2 wollastonite + MgO â?? 0.5 merwinite + 0.5 diopside Using the model of Abart et al. (2009), the effective diffusion coefficients DMgO at 800 °C are estimated at 1.55×10-16± 2.18×10-17 m2/s, and at 900 °C at 2.46×10-16± 3.45×10-17 m2/s. This yields an activation energy of Ea= 45.6 ± 16.4 kJ/mol and a pre-exponential factor log D0 = -13.59 ± 1.26 for the Arrhenius relations to describe the temperature-dependent effective diffusivity of the MgO component in the bimineralic aggregate. IR-spectra revealed distinctive OH-contents in the nominally dry phases monticellite and wollastonite after the experiments, which had not been present in the reactants. Obviously, some hydrogen released by the natural, water-containing CaF2 pressure medium diffused into the capsule, thus producing traces of water inside. The presence of minute amounts of water may strongly enhance the kinetics of the reaction. In fact, if completely waterfree Al2O3-powder is used as pressure medium, no significant reaction occurred, and accordingly, reactants remain OH-free. An Al2O3-layer of 3 mm thickness between the capsule and the CaF2 surrounding delays the onset of rim growth for about one hour. However, once initiated, the reaction progress is the same in instantaneous and delayed reactions. References: Abart R., Petrishcheva E., Fischer F.D., Svoboda J. (2009), Thermodynamic model for diffusion controlled reaction rim growth in a binary system: application to the forsterite-enstatite-quartz system, American Journal of Science, Vol. 309, pp. 114-131

Joachim, B.; Gardes, E.; Heinrich, W.; Abart, R.

2009-04-01

224

Bone Densitometry (Bone Density Scan)  

Science.gov (United States)

... en/safety/) for more information about pregnancy and x-rays. top of page • Equipment There are two types of DXA equipment: a ... one-tenth the dose of a standard chest x-ray, and less than a day's exposure to natural ... equipment is widely available making DXA bone densitometry testing ...

225

Anatomic vs. Acquired Image Frame Discordance in Spectral Domain Optical Coherence Tomography Minimum Rim Measurements  

Science.gov (United States)

Purpose To quantify the effects of using the fovea to Bruch's membrane opening (FoBMO) axis as the nasal-temporal midline for 30° sectoral (clock-hour) spectral domain optical coherence tomography (SDOCT) optic nerve head (ONH) minimum rim width (MRW) and area (MRA) calculations. Methods The internal limiting membrane and BMO were delineated within 24 radial ONH B-scans in 222 eyes of 222 participants with ocular hypertension and glaucoma. For each eye the fovea was marked within the infrared reflectance image, the FoBMO angle (?) relative to the acquired image frame (AIF) horizontal was calculated, the ONH was divided into 30°sectors using a FoBMO or AIF nasal/temporal axis, and SDOCT MRW and MRA were quantified within each FoBMO vs. AIF sector. For each sector, focal rim loss was calculated as the MRW and MRA gradients (i.e. the difference between the value for that sector and the one clockwise to it divided by 30°). Sectoral FoBMO vs. AIF discordance was calculated as the difference between the FoBMO and AIF values for each sector. Generalized estimating equations were used to predict the eyes and sectors of maximum FoBMO vs. AIF discordance. Results The mean FoBMO angle was ?6.6±4.2° (range: ?17° to +7°). FoBMO vs. AIF discordance in sectoral mean MRW and MRA was significant for 7 of 12 and 6 of 12 sectors, respectively (psectoral discordance was predicted by sectoral rim gradient (pregionalize the ONH rather than a line parallel to the AIF horizontal axis significantly influences clock-hour SDOCT rim values. This effect is greatest in eyes with large FoBMO angles and sectors with focal rim loss. PMID:24643069

Yang, Hongli; Hardin, Christy; Reyes, Luke; Reynaud, Juan; Gardiner, Stuart K.; Fortune, Brad; Demirel, Shaban; Burgoyne, Claude F.

2014-01-01

226

Recent studies on the formation of the rim structure and on polygonization in LWR fuel  

International Nuclear Information System (INIS)

At cross sectional burnups in excess of - 40 MWd/kgUO2, a grain subdivision process occurs at the outer rim of LWR UO2 fuel. A similar phenomenon can be observed in the Pu-rich inclusions in MOX fuel. Three phenomena are usually observed in the resulting 'Rim zone': formation of small grains of sub?m size, formation of pores of about ?m size, and reduction of the signal of fission Xe in EPMA measurements. The mechanisms for rim-structure formation are still not fully understood, and it is not completely obvious, whether the above three processes occur simultaneously or one after the other in sequential steps. Also, two different types of small grains have recently been found at CEA in France.The present state of knowledge on rim structure formation in LWR fuel is reviewed, as well as recent progress in observing and understanding the formation of nanocrystals and of polygonization in other ceramics. Controlled ion irradiation techniques, including fission product ions at fission energy (e.g. 72 MeV iodine ions) have been applied to UO2 and to simulated high burnup UO2, so-called SIMFUEL. The process of polygonization, i.e. the rearrangement of dislocations into dislocation walls forming low energy 'sub-boundaries' and rather perfect, but slightly misoriented subgrains, was studied in these experiments. The same experiments confirmed the extreme radiation stability of UO2 and demonstrated effects of fission spikes: fission-induced bubble formation, re-solution of fission gases from bubbles and fission-enhanced gas diffusion and release. No temperature dependence was found between room temperature and 500 deg. C. The combined results are used to discuss possible mechanisms for polygonization and rim structure formation in UO2. (author)

227

Functional coupling of Rab3-interacting molecule 1 (RIM1) and L-type Ca2+ channels in insulin release.  

Science.gov (United States)

Insulin release by pancreatic ?-cells is regulated by diverse intracellular signals, including changes in Ca(2+) concentration resulting from Ca(2+) entry through voltage-gated (Ca(V)) channels. It has been reported that the Rab3 effector RIM1 acts as a functional link between neuronal Ca(V) channels and the machinery for exocytosis. Here, we investigated whether RIM1 regulates recombinant and native L-type Ca(V) channels (that play a key role in hormone secretion) and whether this regulation affects insulin release. Whole-cell patch clamp currents were recorded from HEK-293 and insulinoma RIN-m5F cells. RIM1 and Ca(V) channel expression was identified by RT-PCR and Western blot. RIM1-Ca(V) channel interaction was determined by co-immunoprecipitation. Knockdown of RIM1 and Ca(V) channel subunit expression were performed using small interference RNAs. Insulin release was assessed by ELISA. Co-expression of Ca(V)1.2 and Ca(V)1.3 L-type channels with RIM1 in HEK-293 cells revealed that RIM1 may not determine the availability of L-type Ca(V) channels but decreases the rate of inactivation of the whole cell currents. Co-immunoprecipitation experiments showed association of the Ca(V)? auxiliary subunit with RIM1. The lack of Ca(V)? expression suppressed channel regulation by RIM1. Similar to the heterologous system, an increase of current inactivation was observed upon knockdown of endogenous RIM1. Co-immunoprecipitation showed association of Ca(V)? and RIM1 in insulin-secreting RIN-m5F cells. Knockdown of RIM1 notably impaired high K(+)-stimulated insulin secretion in the RIN-m5F cells. These data unveil a novel functional coupling between RIM1 and the L-type Ca(V) channels via the Ca(V)? auxiliary subunit that contribute to determine insulin secretion. PMID:21402706

Gandini, María A; Sandoval, Alejandro; González-Ramírez, Ricardo; Mori, Yasuo; de Waard, Michel; Felix, Ricardo

2011-05-01

228

Gaucher disease: MR evaluation of bone marrow features during treatment with enzyme replacement  

International Nuclear Information System (INIS)

Purpose: Enzyme replacement therapy (ERT) arrests and reverses the hematological and visceral symptoms of adult Gaucher disease, the most frequent lysosomal storage disorder. There are only a few studies available evaluating bone disease during ERT. The aim of this study was to investigate the features of bone marrow (bm) by magnetic resonance imaging (MRI) in these patients during ERT. Materials and Methods: MRI was performed prospectively in thirty adult type I Gaucher patients before and during ERT with a mean follow-up of 3 years. Spin-echo sequences (T1/T2) of the lower extremities were obtained and the reconversion (response) or lack of reconversion (non-response) to fatty marrow during treatment was analyzed. The morphological features of bm involvement, a homogeneous or non-homogeneous distribution of bm changes and focal bone lesions surrounded by a rim of reduced signal intensity (SI), were analyzed. Results: Infiltration of bm by Gaucher cells is characterized by a reduction of Sl on both T1- and T2-weighted sequences. Bone marrow responses were seen in 19 patients (63%) during treatment. Focal bone lesions, surrounded by a rim of reduced Sl, did not respond to ERT and correlated with a non-homogenous distribution of bone involvement and splenectomy. (orig.)

229

Detection of bone metastases in patients with prostate cancer by {sup 18}F fluorocholine and {sup 18}F fluoride PET-CT: a comparative study  

Energy Technology Data Exchange (ETDEWEB)

The aim of this prospective study was to compare the potential value of {sup 18}F fluorocholine (FCH) and {sup 18}F fluoride positron emission tomography (PET)-CT scanning for the detection of bony metastases from prostate cancer. Thirty-eight men (mean age, 69{+-}8 years) with biopsy-proven prostate cancer underwent both imaging modalities within a maximum interval of 2 weeks. Seventeen patients were evaluated preoperatively, and 21 patients were referred for post-operative evaluation of suspected recurrence or progression based on clinical algorithms. The number, sites and morphological patterns of bone lesions on {sup 18}F FCH and {sup 18}F fluoride PET-CT were correlated: Concordant lesions between the two modalities with corresponding changes on CT were considered to be positive for malignancy; discordant lesions were verified by follow-up examinations. The mean follow-up interval was 9.1 months. Overall, 321 lesions were evaluated in this study. In a lesion-based analysis, a relatively close agreement was found between these two imaging modalities for detection of malignant bone lesions (kappa=0.57), as well as in a patient-based analysis (kappa=0.76). Sixteen malignant sclerotic lesions with a high density were negative in both {sup 18}F FCH and {sup 18}F fluoride PET-CT [ mean Hounsfield unit (HU), 1,148{+-}364]. There was also a significant correlation between tracer intensity by SUV and density of sclerotic lesions by HU both in {sup 18}F FCH PET-CT (r=-0.28, p<0.006) and {sup 18}F fluoride PET-CT (r=-0.20, p<0.05). The sensitivity, specificity and accuracy of PET-CT in the detection of bone metastases in prostate cancer was 81%, 93% and 86% for {sup 18}F fluoride, and 74% (p=0.12), 99% (p=0.01) and 85% for FCH, respectively. {sup 18}F FCH PET-CT led to a change in the management in two out of 38 patients due to the early detection of bone marrow metastases. {sup 18}F fluoride PET-CT identified more lesions in some patients when compared with {sup 18}F FCH PET-CT but did not change patient management. FCH PET-CT may be superior for the early detection (i.e. bone marrow involvement) of metastatic bone disease. In patients with FCH-negative suspicious sclerotic lesions, a second bone-seeking agent (e.g. {sup 18}F fluoride) is recommended. {sup 18}F fluoride PET-CT demonstrated a higher sensitivity than {sup 18}F FCH PET-CT, but the difference was not statistically significant. Furthermore, {sup 18}F fluoride PET could be also negative in highly dense sclerotic lesions, which presumably reflects the effect of treatment. It will be important to clarify in future studies whether these lesions are clinically relevant when compared with metabolically active bone metastases. (orig.)

Beheshti, Mohsen; Vali, Reza; Fitz, Friedrich; Nader, Michael; Langsteger, Werner [St. Vincent' s Hospital, Nuclear Medicine and Endocrinology, PET-CT Center LINZ, Linz, Uperaustria (Austria); Waldenberger, Peter [St. Vincent' s Hospital, Radiology, Linz (Austria); Loidl, Wolfgang; Stoiber, Franz [St. Vincent' s Hospital, Urology, Linz (Austria); Broinger, Gabriele [St. Vincent' s Hospital, Pathology, Linz (Austria); Foglman, Ignac [Guy' s and St. Thomas' NHS Foundation Trust, Nuclear Medicine, London (United Kingdom)

2008-10-15

230

Constitutive Activation of the pH-Responsive Rim101 Pathway in Yeast Mutants Defective in Late Steps of the MVB/ESCRT Pathway  

OpenAIRE

In many fungi, transcriptional responses to alkaline pH are mediated by conserved signal transduction machinery. In the homologous system in Saccharomyces cerevisiae, the zinc-finger transcription factor Rim101 is activated under alkaline conditions to regulate transcription of target genes. The activation of Rim101 is exerted through proteolytic processing of its C-terminal inhibitory domain. Regulated processing of Rim101 requires several proteins, including the calpain-like protease Rim13/...

Hayashi, Michio; Fukuzawa, Takaaki; Sorimachi, Hiroyuki; Maeda, Tatsuya

2005-01-01

231

Bone Lesions and Damage  

Science.gov (United States)

... NOW Home » About Multiple Myeloma » Symptoms » Bone Damage Bone Lesions and Damage Bone lesions from multiple myeloma are the primary cause ... x-ray and are referred to as osteolytic lesions. These bone lesions weaken the bone, causing pain and increasing ...

232

FIB-NanoSIMS-TEM Coordinated Study of a Wark-Lovering Rim in a Vigarano Type A CAI  

Science.gov (United States)

Wark-Lovering (WL) rims are thin multi layered mineral sequences that surround most Ca, Al-rich inclusions (CAIs). Unaltered WL rims are composed of the same primary high temperature minerals as CAIs, such as melilite, spinel, pyroxene, hibonite, perovskite, anorthite and olivine. It is still unclear whether the rim minerals represent a different generation formed by a separate event from their associated CAIs or are a byproduct of CAI formation. Several models have been proposed for the origins of WL rims including condensation, flashheating, reaction of a CAI with a Mg-Si-rich reservoir (nebular gas or solid); on the basis of mineralogy, abundances of trace elements, O and Mg isotopic studies. Detailed mineralogical characterizations of WL rims at micrometer to nanometer scales have been obtained by TEM observations, but so far no coordinated isotopic - mineralogical studies have been performed. Thus, we have applied an O isotopic imaging technique by NanoSIMS 50L to investigate heterogeneous distributions of O isotopic ratios in minerals within a cross section of a WL rim prepared using a focused ion beam (FIB) instrument. After the isotopic measurements, we determine the detailed mineralogy and microstructure of the same WL FIB section to gain insight into its petrogenesis. Here we present preliminary results from O isotopic and elemental maps by NanoSIMS and mineralogical analysis by FE-SEM of a FIB section of a WL rim in the Vigarano reduced CV3 chondrite.

Cai, A.; Ito, M.; Keller, L. P.; Ross, D. K.; Nakamura-Messenger, K.

2010-01-01

233

Juvenile Ossifying Fibroma with Aneurysamal Bone Cyst: A Case Report  

Science.gov (United States)

The fibro osseous lesions of the jaws represent a diverse group of entities that are characterized by replacement of normal bone by a fibrous connective tissue matrix, with in which varying amounts of osteoid, immature and mature bone and in some instances, cementum like material are deposited. Fibro osseous lesions of the jaws include developmental (hamartomatous) lesions, reactive or dysplastic processes and neoplasms. Juvenile ossifying fibroma (JOF) is a unique fibro osseous neoplasm. It has 2 histopathological variants (1) Trabecular juvenile ossifying fibroma (TrJOF) and (2) Psammomatoid juvenile ossifying fibroma (PsJOF) with TrJOF affecting the jaws of children. Only 20% of the patients are over 15 years of age. JOF is more common in maxilla than mandible. Origin in extragnathic locations is extremely rare. It presents as an asymptomatic progressive, rapid expansion of jaws. Radiographically, tumour is well circumscribed, along with lack of continuity with adjacent bone, cortical expansion & perforation. Histopathologically it consists of a cell rich fibrous stroma with bundles of cellular osteoid and bone trabeculae without osteoblastic rimming, and aggregates of giant cells. It has a recurrence rate of 30-58%. Long standing lesions shows cystic changes. Aneurysmal bone cyst is the most common complication. Here we present a case report of 16 yr old female patient with clinical, radiographic & histopathological features of Trabecular JOF with Aneurysmal bone cyst. PMID:25478458

Reddy, K Rajeev Kumar; Prakash, A Ravi; Rajinikanth; Vidhyadhari, Pavani

2014-01-01

234

Juvenile ossifying fibroma with aneurysamal bone cyst: a case report.  

Science.gov (United States)

The fibro osseous lesions of the jaws represent a diverse group of entities that are characterized by replacement of normal bone by a fibrous connective tissue matrix, with in which varying amounts of osteoid, immature and mature bone and in some instances, cementum like material are deposited. Fibro osseous lesions of the jaws include developmental (hamartomatous) lesions, reactive or dysplastic processes and neoplasms. Juvenile ossifying fibroma (JOF) is a unique fibro osseous neoplasm. It has 2 histopathological variants (1) Trabecular juvenile ossifying fibroma (TrJOF) and (2) Psammomatoid juvenile ossifying fibroma (PsJOF) with TrJOF affecting the jaws of children. Only 20% of the patients are over 15 years of age. JOF is more common in maxilla than mandible. Origin in extragnathic locations is extremely rare. It presents as an asymptomatic progressive, rapid expansion of jaws. Radiographically, tumour is well circumscribed, along with lack of continuity with adjacent bone, cortical expansion & perforation. Histopathologically it consists of a cell rich fibrous stroma with bundles of cellular osteoid and bone trabeculae without osteoblastic rimming, and aggregates of giant cells. It has a recurrence rate of 30-58%. Long standing lesions shows cystic changes. Aneurysmal bone cyst is the most common complication. Here we present a case report of 16 yr old female patient with clinical, radiographic & histopathological features of Trabecular JOF with Aneurysmal bone cyst. PMID:25478458

Reddy, A Vikram Simha; Reddy, K Rajeev Kumar; Prakash, A Ravi; Rajinikanth; Vidhyadhari, Pavani

2014-10-01

235

[Unusual radiologic signs of bone echinococcosis in children].  

Science.gov (United States)

The authors report 2 cases of 2 children aging 11 and 12-years-old presenting hydatitosis in the upper extremity of 2 long bones femur and tibia. In 2 cases, radiological appearances were atypical. In the femur, plain radiographs revealed multiple lucencies, irregular, located in the superior extremity with a periostal reaction. The CT scan confirmed these data and showed a cortical rupture, extension to soft tissue with contrast enhancement. In the tibia, plain radiographys showed delimitated lucencies, confluent with a rim condensation in the proximal epiphyseal-metaphyseal area. Echography and CT are helpful when radiological appearances are unusual. PMID:11416800

Smida, M; Jalel, C; Mrad, K; Sayed, M; Ben Abdallah, O; Ben Chehida, F; Ben Ghachem, M

2001-05-01

236

The CT flare response of metastatic bone disease in prostate cancer  

International Nuclear Information System (INIS)

Background New or worsening bone lesions in patients responding to treatment, known as the flare phenomenon is well described on 99mTc-MDP bone scintigraphy, but to our knowledge has not previously been described on CT. The appearance of new or worsening bone sclerosis on CT in patients with prostate cancer may therefore be erroneously classified as disease progression. Purpose To assess the incidence of osteoblastic healing flare response at 3-month CT assessment in patients with castrate-resistant prostate cancer and to identify associated features that enable differentiation from progressive metastatic bone disease at 3 months. Material and Methods CT scans of 67 patients with castrate-resistant prostate cancer undergoing treatment were reviewed by a radiologist blinded to clinical outcome. Changes in number, size, and density of metastatic bone lesions were documented and Response Evaluation Criteria in Solid Tumours (RECIST) in soft tissue lesions, alkaline phosphatase, prostate specific antigen, and 99mTc-MDP bone scans were used for correlation. Results Of the 39 patients who had 3- and 6-month follow-up, eight patients (21%) demonstrated an increase in number, size, or density of sclerotic lesions on the 3-month CT scan despite improvement in PSA and soft tissue lesions. Three out of eight patients (8%) maintained partial response/remained stable at follow-up and were defined as showing a flare response: in this group bone metastases evidsponse: in this group bone metastases evident on CT showed a qualitative and quantitative increase in density and no lesions faded at 3 months. In contrast, in all patients who progressed at 3 months by PSA/RECIST criteria (n = 8) bone lesions showed a mixed pattern with some lesions increasing and others decreasing in density. Conclusion The incidence of flare response of metastatic bone disease evident at 3-month post-treatment CT in patients with prostate cancer undergoing systemic treatment is 8%. In patients with falling PSA and stable/responding soft tissue disease at 3 months an increase in bone sclerosis in the absence of fading bone metastases can be interpreted as flare and is likely to represent a response

237

A sign-reversing involution for rooted special rim-hook tableaux  

CERN Document Server

Egecioglu and Remmel gave an interpretation for the entries of the inverse Kostka matrix K^{-1} in terms of special rim-hook tableaux. They were able to use this interpretation to give a combinatorial proof that KK^{-1}=I but were unable to do the same for the equation K^{-1}K=I. We define a sign-reversing involution on rooted special rim-hook tableaux which can be used to prove that the last column of this second product is correct. In addition, following a suggestion of Chow we combine our involution with a result of Gasharov to give a combinatorial proof of a special case of the (3+1)-free Conjecture of Stanley and Stembridge.

Sagan, B E; Sagan, Bruce E.; Lee, Jaejin

2003-01-01

238

Upper lid transconjunctival versus transcutaneous approach for fracture repair of the lateral orbital rim.  

Science.gov (United States)

The use of the lower eyelid transconjunctival approach in the setting of orbital trauma has becoming increasingly popular in recent years. However, experience has found that access to the lateral orbital rim can be somewhat limited with this type of incision. Many authors supplement the approach with a lateral canthotomy in order to gain adequate access laterally. Although usually well tolerated, there can be side effects associated with this incision. We examine the upper lid transconjunctival approach to the lateral orbital rim. Furthermore, we compare this technique to the more traditional transcutaneous approaches used for orbital trauma. We have found this technique to be safe, effective, and to cause no more complications than the more traditional approaches. PMID:20548223

Langsdon, Phillip R; Rohman, Grant T; Hixson, Rob; Stumpe, Matthew R; Metzinger, Stephen E

2010-07-01

239

Dorsal acetabular rim radiographic view for evaluation of the canine hip  

International Nuclear Information System (INIS)

A dorsal acetabular rim (DAR) radiographic view and positioning was devised to visualize the weight-bearing of the acetabulum of dogs for hip evaluation. The DAR view was performed on 250 dogs including 38 breeds. Both males and females were evaluated; ages ranged from six weeks to 11 years. The value of this technique is to evaluate the dorsal rim of the acetabulum for damage and secondary osteoarthritic changes, to correlate palpation of joint capsule laxity and crepitation with the radiographic appearance, to show acetabular filling, and to have an objective reproducible tool for determining whether a hip is normal, dysplastic or injured. This view is recommended as part of the routine procedure for hip examination

240

Asia/Pacific Rim renewable energy market assessments by the State of Hawaii  

International Nuclear Information System (INIS)

The State of Hawaii has begun to encourage its economic growth and diversification by increasing the export of U.S. energy, environment, ocean, and information technologies. Hawaii's Strategic Technology Market Assessment and Development (STMAD) program promotes the transfer of U.S. technology into Asia and the Pacific Rim, locations having phenomenal growth potential and vast technological infrastructure demands. The STMAD program is managed by the State's Department of Business, Economic Development and Tourism (DBEDT). Under the auspices of STMAD, the Hawaii Natural Energy Institute (HNEI) of the University of Hawaii is assessing biomass energy resources of Asian and Pacific Rim countries to identify and investigate sustainable energy markets. This paper reviews the STMAD program and reports findings of renewable energy assessment performed by HNEI and DBEDT. (author)

241

Ultrasonic inspection method and system for detection of steeple cracking in turbine disk rims  

International Nuclear Information System (INIS)

Steam turbine disks which operate under high cyclic stress in a moist environment can develop cracks in the disk-rim steeples. Detection of these cracks using nondestructive testing methods is necessary to assure safe operation and avoid unnecessary disk replacement. Both magnetic particle (MT) and ultrasonic testing (UT) can be used to inspect the steeples; however, UT can be used without removing the blades. A system for inspecting bladed steeples has been developed that can be applied on a range of disks including those in Westinghouse, General Electric, and Allis Chalmers turbines. The system performs an inspection as the turbine is rotated at slow speeds over turning rolls. This procedure greatly reduces inspection time because the inspection can be done without deblading the disk or resetting the inspection equipment for different rim segments

242

Metastatic Bone Disease  

Science.gov (United States)

... 2013 by the American Academy of Orthopaedic Surgeons. Metastatic Bone Disease Cancer that begins in an organ, ... prostate, and then spreads to bone is called metastatic bone disease (MBD). More than 1.2 million ...

243

Osteoporosis: The Bone Thief  

Science.gov (United States)

... of this makes your bones weaker. Who Has Osteoporosis? Ten million Americans have osteoporosis. They are mostly ... a bone. What Can I Do For My Osteoporosis? Treating osteoporosis means stopping the bone loss and ...

244

Sources of Tropospheric Ozone along the Asian Pacific Rim: An Analysis of Ozonesonde Observations  

Science.gov (United States)

The sources contributing to tropospheric ozone over the Asian Pacific Rim in different seasons are quantified by analysis of Hong Kong and Japanese ozonesonde observations with a global three-dimensional (3-D) chemical transport model (GEOS-CHEM) driven by assimilated meteorological observations. Particular focus is placed on the extensive observations available from Hong Kong in 1996. In the middle-upper troposphere (MT- UT), maximum Asian pollution influence along the Pacific Rim occurs in summer, reflecting rapid convective transport of surface pollution. In the lower troposphere (LT) the season of maximum Asian pollution influence shifts to summer at midlatitudes from fall at low latitudes due to monsoonal influence. The UT ozone minimum and high variability observed over Hong Kong in winter reflects frequent tropical intrusions alternating with stratospheric intrusions. Asian biomass burning makes a major contribution to ozone at less than 32 deg.N in spring. Maximum European pollution influence (less than 5 ppbv) occurs in spring in the LT. North American pollution influence exceeds European influence in the UT-MT, reflecting the uplift from convection and the warm conveyor belts over the eastern seaboard of North America. African outflow makes a major contribution to ozone in the low-latitude MT-UT over the Pacific Rim during November- April. Lightning influence over the Pacific Rim is minimum in summer due to westward UT transport at low latitudes associated with the Tibetan anticyclone. The Asian outflow flux of ozone to the Pacific is maximum in spring and fall and includes a major contribution from Asian anthropogenic sources year-round.

Liu, Hong-Yu; Jacob, Daniel J.; Chan, Lo Yin; Oltmans, Samuel J.; Bey, Isabelle; Yantosca, Robert M.; Harris, Joyce M.; Duncan, Bryan N.; Martin, Randall V.

2002-01-01

245

Oxygen Isotope Measurements of a Rare Murchison Type A CAI and Its Rim  

Science.gov (United States)

Ca-, Al-rich inclusions (CAIs) from CV chondrites commonly show oxygen isotope heterogeneity among different mineral phases within individual inclusions reflecting the complex history of CAIs in both the solar nebula and/or parent bodies. The degree of isotopic exchange is typically mineral-specific, yielding O-16-rich spinel, hibonite and pyroxene and O-16-depleted melilite and anorthite. Recent work demonstrated large and systematic variations in oxygen isotope composition within the margin and Wark-Lovering rim of an Allende Type A CAI. These variations suggest that some CV CAIs formed from several oxygen reservoirs and may reflect transport between distinct regions of the solar nebula or varying gas composition near the proto-Sun. Oxygen isotope compositions of CAIs from other, less-altered chondrites show less intra-CAI variability and 16O-rich compositions. The record of intra-CAI oxygen isotope variability in CM chondrites, which commonly show evidence for low-temperature aqueous alteration, is less clear, in part because the most common CAIs found in CM chondrites are mineralogically simple (hibonite +/- spinel or spinel +/- pyroxene) and are composed of minerals less susceptible to O-isotopic exchange. No measurements of the oxygen isotope compositions of rims on CAIs in CM chondrites have been reported. Here, we present oxygen isotope data from a rare, Type A CAI from the Murchison meteorite, MUM-1. The data were collected from melilite, hibonite, perovskite and spinel in a traverse into the interior of the CAI and from pyroxene, melilite, anorthite, and spinel in the Wark-Lovering rim. Our objectives were to (1) document any evidence for intra-CAI oxygen isotope variability; (2) determine the isotopic composition of the rim minerals and compare their composition(s) to the CAI interior; and (3) compare the MUM-1 data to oxygen isotope zoning profiles measured from CAIs in other chondrites.

Matzel, J. E. P.; Simon, J. I.; Hutcheon, I. D.; Jacobsen, B.; Simon, S. B.; Grossman, L.

2013-01-01

246

Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis  

OpenAIRE

Abstract Background The autophagic vacuolar myopathies (AVM) are a group of inherited myopathies defined by the presence of autophagic vacuoles in pathological muscle specimens. AVM can be categorized into three groups: acid maltase deficiency, myopathies characterized by autophagic vacuoles with unique sarcolemmal features, and rimmed vacuolar myopathies (RVM). While the pathogeneses of these conditions are still being elucidated, some drugs (e.g., chloroquine, its analog, h...

Bokuda Kota; Sugaya Keizo; Tamura Shunichiro; Miyamoto Kazuhito; Matsubara Shiro; Komori Takashi

2012-01-01

247

Subperiosteal ganglion associated with Paget's disease of bone  

International Nuclear Information System (INIS)

Tumoral lesions related to Paget's disease may be classified as malignant, benign or pseudotumoral. While sarcomatous degeneration is the most feared complication, awareness of benign and pseudotumoral lesions is essential for assisting in accurate histological interpretation of the biopsy sample, which may avoid unnecessary repeat biopsies. We present the first case of a juxta-articular subperiosteal ganglion associated with Paget's disease, with classic imaging characteristics, especially on CT examination. The well-defined soft tissue mass at the medial aspect of the obturator rim, adjacent to a small fracture in pagetic quadrilateral plate, showed an ossified rim and internal gas lucencies, these being the hallmarks of a juxta-articular subperiosteal ganglion. On MRI, the lesion was of intermediate signal intensity on T1-weighted sequences, increased signal intensity on T2-weighted sequences, with rim enhancement after gadolinium contrast injection and preservation of fatty marrow signal of the underlying pagetic bone. Identification of the entity avoided an unnecessary biopsy or surgical intervention. (orig.)

248

The significance of evaluating the craniolateral acetabular rim for hip dysplasia  

International Nuclear Information System (INIS)

The weight-bearing part of the canine hip is its dorsocraniolateral portion. On the radiograph the configuration of the craniolateral acetabular rim is important for evaluation of hip dysplasia. Changes in formation of this area should be differentiated from artefacts due to malpositioning. When the pelvis is tilted dorsally, the cranial acetabular rim is superimposed on the cranioventral acetabular contour and the acetabular roof. The craniolateral contour then seems to be missing. The contours of a ventrally tilted pelvis do not overlap, but it is difficult to discern the craniolateral rim. The reference points for Norberg-Olsson's measurements are difficult to choose in both cases and the angles may vary up to 10 degrees. A symmetrically positioned pelvis shows one point of reference for Norberg-Olsson's measurement where the cranial acetabular contour, the cranioventral margin and the acetabular roof intersect. Therefore poor positioning of the pelvis for radiographic evaluation of hip dysplasia should be avoided when using Norberg-Olsson's measurements

249

Suzaku Observations across the Cygnus Loop from the Northeastern to the Southwestern Rim  

CERN Document Server

We have observed the Cygnus Loop from the northeast (NE) rim to the southwest (SW) rim using Suzaku in 10 pointings that is just north of previous XMM-Newton observations. The observation data obtained were divided into 45 rectangular regions where the width were configured so that each region holds 8000$-$12000 photons. The spectrum acquired from each region was fitted either with one-kTe-component non-equilibrium ionization (NEI) model or with two-kTe-component NEI model. The two-kTe-component model yields significantly better fit in almost all the non-rim regions. Judging from abundances and flux, the high-kTe-component (0.4$-$0.8keV) must be the ejecta origin, while the low-\\kTe-component ($\\sim$0.3keV) comes from the swept-up matter. We found that swept-up matter shell is very thin in just southwest of center of the Loop. Together with previous observations, we estimate the diameter of this thin shell region to be $1^{\\circ}$. We also found that the ejecta distributions were asymmteric to the geometric c...

Kimura, Masashi; Katsuda, Satoru; Uchida, Hiroyuki

2008-01-01

250

Energy indicators series: analyzing the energy-related evidence of economic transition in the Pacific Rim  

International Nuclear Information System (INIS)

In recent years, much attention has been focused upon the Asian Pacific countries as constituting an economic 'miracle' over the last two decades. Economic growth in the Pacific Rim has been higher than in any other area of the world. The rapid industrialization process and its impact on the economies of these countries, at both macro and micro levels, are discussed widely in the economic literature. Of particular interest are the fundamental structural changes these countries have experienced in their transition to industrialized economies. This instalment of the annual 'Energy indicators' series concentrates on Pacific Rim countries, namely Hong Kong, the Philippines, Singapore, South Korea, Taiwan and Thailand. Similar to other experiences, rapid economic growth in these countries has been accompanied by 'spectacular' growth in demand for energy. Therefore, this year's paper not only underlines certain trends in these six energy markets but also attempts to test the phenomenon 'threshold country', i.e., shifting from the developing to the industrialized world by using common indicators and methodologies. The analysis starts with a comparison of energy intensities. Section 2 provides an overview of the socio-economic and energy indicators of the Pacific Rim countries. Section 3 introduces a standard econometric model on the most dynamic consuming sector, namely transport. Section 4 presents the projections of consumption in this sector and discusses policy issues. Sthis sector and discusses policy issues. Some concluding remarks in Section 6 complete the paper. (author)

251

Does Oxygen Isotopic Heterogeneity in Refractory Inclusions and Their Wark-Lovering Rims Record Nebular Repressing?  

Science.gov (United States)

Large systematic variations in O-isotopic compositions found within individual mineral layers of rims surrounding Ca-, Al-rich inclusions (CAIs) and at the margins of some CAIs imply formation from distinct environments [e.g., 1-3]. The O-isotope compositions of many CAIs preserve a record of the Solar nebula gas believed to initially be O-16-rich (delta O-17 less than or equal to -25%0) [4-5]. Data from a recent study of the compact Type A Allende CAI, A37, preserve a diffusion profile in the outermost 70 micrometers of the inclusion and show greater than 25%0 variations in delta O-17 within its 100 micrometer-thick Wark-Lovering rim (WL-rim) [3]. This and comparable heterogeneity measured in several other CAIs have been explained by isotopic mixing between the O-16-rich Solar reservoir and a second O-16-poor reservoir (probably nebular gas) with a planetary-like isotopic composition, e.g., [1,2,3,6]. However, there is mineralogical and isotopic evidence from the interiors of CAIs, in particular those from Allende, for parent body alteration. At issue is how to distinguish the record of secondary reprocessing in the nebula from that which occurred on the parent body. We have undertaken the task to study a range of CAI types with varying mineralogies, in part, to address this problem.

Simon, J. I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.

2013-01-01

252

A Compact Array imaging survey of southern bright-rimmed clouds  

CERN Document Server

We have carried out a radio-wavelength imaging survey of 45 bright-rimmed clouds (BRCs), using the Australia Telescope Compact Array to characterise the physical properties in their ionised boundary layers. We detected radio emission from a total of 25 clouds and using a combination of Digitised Sky Survey and mid-infrared MSX micron images classified the emission into that associated with the ionised cloud rims, that associated with embedded possible massive YSOs and that unlikely to be associated with the clouds at all. A total of 18 clouds display radio emission clearly associated with the cloud rim and we determine the ionising photon flux illuminating these clouds and the electron density and pressure of their ionised boundary layers. Using a global estimate for the interior molecular pressure of these clouds we show that the majority are likely to be in pressure equilibrium and hence are currently being shocked by photoionisation-induced shocks. We identify those clouds where the predicted ionising phot...

Thompson, M A; White, G J

2004-01-01

253

Young Stellar Population of the Bright-Rimmed Clouds BRC 5, BRC 7 and BRC 39  

CERN Document Server

Bright-rimmed clouds (BRCs), illuminated and shaped by nearby OB stars, are potential sites of recent/ongoing star formation. Here we present an optical and infrared photometric study of three BRCs: BRC 5, BRC 7 and BRC 39 to obtain a census of the young stellar population, thereby inferring the star formation scenario, in these regions. In each BRC, the Class I sources are found to be located mostly near the bright rim or inside the cloud, whereas the Class II sources are preferentially outside, with younger sources closer to the rim. This provides strong support to sequential star formation triggered by radiation driven implosion due to the UV radiation. Moreover, each BRC contains a small group of young stars being revealed at its head, as the next-generation stars. In particular, the young stars at the heads of BRC 5 and BRC 7 are found to be intermediate/high mass stars, which, under proper conditions, may themselves trigger further star birth, thereby propagating star formation out to long distances.

Panwar, Neelam; Pandey, A K; Samal, M R; Ogura, K; Ojha, D K; Jose, J; Bhatt, B C

2014-01-01

254

The CT flare response of metastatic bone disease in prostate cancer  

Energy Technology Data Exchange (ETDEWEB)

Background New or worsening bone lesions in patients responding to treatment, known as the flare phenomenon is well described on 99mTc-MDP bone scintigraphy, but to our knowledge has not previously been described on CT. The appearance of new or worsening bone sclerosis on CT in patients with prostate cancer may therefore be erroneously classified as disease progression. Purpose To assess the incidence of osteoblastic healing flare response at 3-month CT assessment in patients with castrate-resistant prostate cancer and to identify associated features that enable differentiation from progressive metastatic bone disease at 3 months. Material and Methods CT scans of 67 patients with castrate-resistant prostate cancer undergoing treatment were reviewed by a radiologist blinded to clinical outcome. Changes in number, size, and density of metastatic bone lesions were documented and Response Evaluation Criteria in Solid Tumours (RECIST) in soft tissue lesions, alkaline phosphatase, prostate specific antigen, and 99mTc-MDP bone scans were used for correlation. Results Of the 39 patients who had 3- and 6-month follow-up, eight patients (21%) demonstrated an increase in number, size, or density of sclerotic lesions on the 3-month CT scan despite improvement in PSA and soft tissue lesions. Three out of eight patients (8%) maintained partial response/remained stable at follow-up and were defined as showing a flare response: in this group bone metastases evident on CT showed a qualitative and quantitative increase in density and no lesions faded at 3 months. In contrast, in all patients who progressed at 3 months by PSA/RECIST criteria (n = 8) bone lesions showed a mixed pattern with some lesions increasing and others decreasing in density. Conclusion The incidence of flare response of metastatic bone disease evident at 3-month post-treatment CT in patients with prostate cancer undergoing systemic treatment is 8%. In patients with falling PSA and stable/responding soft tissue disease at 3 months an increase in bone sclerosis in the absence of fading bone metastases can be interpreted as flare and is likely to represent a response

Messiou, Christina; deSouza, Nandita M. (Cancer Research UK Clinical Magnetic Resonance Research Group, Inst. of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey (United Kingdom)), email: Christina.Messiou@icr.ac.uk; Cook, Gary (Dept. of Nuclear Medicine, Royal Marsden NHS Foundation Trust, Surrey (United Kingdom)); Reid, Alison H.M.; Attard, Gerhardt; Dearnaley, David; deBono, Johann S. (Inst. of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey (United Kingdom))

2011-06-15

255

Factors affecting bone growth.  

Science.gov (United States)

Bone growth and development are products of the complex interactions of genetic and environmental factors. Longitudinal bone growth depends on the growth plate. The growth plate has 5 different zones-each with a different functional role-and is the final target organ for longitudinal growth. Bone length is affected by several systemic, local, and mechanical factors. All these regulation systems control the final length of bones in a complicated way. Despite its significance to bone stability, bone growth in width has not been studied as extensively as longitudinal bone growth. Bone growth in width is also controlled by genetic factors, but mechanical loading regulates periosteal apposition. In this article, we review the most recent data regarding bone growth from the embryonic age and analyze the factors that control bone growth. An understanding of this complex system is important in identifying metabolic and developmental bone diseases and fracture risk. PMID:25658073

Gkiatas, Ioannis; Lykissas, Marios; Kostas-Agnantis, Ioannis; Korompilias, Anastasios; Batistatou, Anna; Beris, Alexandros

2015-02-01

256

Development of high sensitive and reliable FFD and sodium leak detection technique for fast reactor using RIMS  

International Nuclear Information System (INIS)

The high sensitive fuel failure and sodium leak detection technique for fast reactors has been developed using laser resonance ionization mass spectrometry (RIMS) method. The RIMS is suitable for the isotope analysis of the element of ultra trace level, since there is no increase of the background by interfering ion and isobaric interference except for measuring element, because the measuring element is selectively ionized. The RIMS was applied to measure the artificially blended xenon and krypton gas (tag gas) which is used for the pressurized steel capsule of in-pile creep rupture experiment in the experimental fast reactor Joyo. This system can measure the tag gas isotopic ratios of about 100 ? 102 ppb level and the measured results could identify tag gas. The RIMS system can detect stable xenon nuclides and 133Xe in the sample of cover gas which was stored in the stainless steel container during the fuel failure simulation test in Joyo. The result shows the applicability of the RIMS system for assuming the burn-up of the failed fuel subassembly by the ratio of stable and radioactive xenon isotopes. The RIMS is then applied to detect a small amount of sodium leaks from the fast reactor cooling system. In case of detecting sodium isotopes using RIMS, the aerodynamic lens was newly introduced, which can transfer aerosols at atmospheric pressure into a vacuum chamber while increasing the aerosol density at the same time. We performedl density at the same time. We performed the experiments using stable isotope 23Na to evaluate the detection sensitivity of the prototype system. The preliminary test results showed that prototype system could easily detect sodium aerosol of 2.7 ppt, of which sensitivity is 400 times higher than the conventional sodium leak detectors currently used. The RIMS system is expected to be a promising innovative instrumentation system not only for Monju, but also for the future sodium cooled fast reactors. (author)

257

Cryptococcus neoformans Rim101 Is Associated with Cell Wall Remodeling and Evasion of the Host Immune Responses  

OpenAIRE

Infectious microorganisms often play a role in modulating the immune responses of their infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 transcription factor to regulate cell wall composition and the host-pathogen interface. In the absence of Rim101, C. neoformans exhibits an altered cell surface in response to host signals, generating an excessive and ineffective immune response that results in accelerated host death. This host immune response to the ri...

O Meara, Teresa R.; Holmer, Stephanie M.; Selvig, Kyla; Dietrich, Fred; Alspaugh, J. Andrew

2013-01-01

258

Paget's sarcoma of bone  

International Nuclear Information System (INIS)

The most sinister complication of Paget's disease is malignant degeneration. The true etiology of Paget's disease remains unproven and unknown. The relative incidence of sarcoma ranges from 0.9% to 20% depending upon the population source. The anatomical distribution of lesions is similar to that of uncomplicated Paget's disease except for the high incidence in the humerus and rare occurrence in the spine. Approximately 50% of the lesions histologically represent osteosarcomas, with fibrosarcoma, fibrous histiocytoma, chondrosarcoma and giant cell tumor rarely occurring. The radiographic presentation is most commonly lytic, but sclerotic and mixed patterns occur. Cortical destruction and soft tissue mass are the cardinal radiographic signs. Malignant periosteal response is seldom found associated with Paget's sarcoma. The most common sites are femur, humerus, pelvis, skull and tibia. The prognosis is fatal at a very rapid rate. There are but a few isolated cases of long-term survival reported. (orig.)

259

Bone grafting: An overview  

Directory of Open Access Journals (Sweden)

Full Text Available Bone grafting is the process by which bone is transferred from a source (donor to site (recipient. Due to trauma from accidents by speedy vehicles, falling down from height or gunshot injury particularly in human being, acquired or developmental diseases like rickets, congenital defects like abnormal bone development, wearing out because of age and overuse; lead to bone loss and to replace the loss we need the bone grafting. Osteogenesis, osteoinduction, osteoconduction, mechanical supports are the four basic mechanisms of bone graft. Bone graft can be harvested from the iliac crest, proximal tibia, proximal humerus, proximal femur, ribs and sternum. An ideal bone graft material is biologically inert, source of osteogenic, act as a mechanical support, readily available, easily adaptable in terms of size, shape, length and replaced by the host bone. Except blood, bone is grafted with greater frequency. Bone graft indicated for variety of orthopedic abnormalities, comminuted fractures, delayed unions, non-unions, arthrodesis and osteomyelitis. Bone graft can be harvested from the iliac crest, proximal tibia, proximal humerus, proximal femur, ribs and sternum. By adopting different procedure of graft preservation its antigenicity can be minimized. The concept of bone banking for obtaining bone grafts and implants is very useful for clinical application. Absolute stability require for successful incorporation. Ideal bone graft must possess osteogenic, osteoinductive and osteocon-ductive properties. Cancellous bone graft is superior to cortical bone graft. Usually autologous cancellous bone graft are used as fresh grafts where as allografts are employed as an alloimplant. None of the available type of bone grafts possesses all these properties therefore, a single type of graft cannot be recomm-ended for all types of orthopedic abnormalities. Bone grafts and implants can be selected as per clinical problems, the equipments available and preference of the surgeon. A search for ideal bone graft is on and may continue till time to time. [Vet World 2010; 3(4.000: 198-200

D. O. Joshi

2010-08-01

260

Are archaeological bones similar to modern bones  

International Nuclear Information System (INIS)

An assessment is made of the analytical reliability of the INAA determination of major and trace elements, using their short-lives radioisotopes in both regular and defatted modern cancellous bone, and in modern cortical bone. This modern bone information is then compared with analytical data for bones from Egyptian mummies ranging in age from approx. 2000 to approx. 3700 BP, and with normally-buried 11th century French bones. Diagenetic effects may readily be detected by the measurement of elevated quantities of V, Mn and Al in soil-contaminated bones. The Ca to P concentration ratios and the organic content may also be used to separate bone from diagenetically altered archeological specimens. (author)

261

Application of bone scintigraphy  

International Nuclear Information System (INIS)

Bone scanning has varied applications, particularly in the file of oncology. It is used in the diagnosis and follow-up of patients with cancers that metastatize to the bones (breast, prostate CA), also in primary bone cancers, infections of the bones and joints. In early stages of primary breast CA (stage I and II), the incidence of unsuspected bone metastasis is only 1-5%. On the other hand, bone scans serve as a baseline study if bone mets occur at some later stage. In patients with stage II and III breast CA, the conversion from normal to abnormal bone scans is 15% and 17%, respectively, clearly in favor of a baseline bone scan. For prostate CA, bone scanning should be used in conjunction with PSA level determination. In advanced disease, a bone scan will define the extent of the metastases, show problematic lesions in weight-bearing bones, and even allow us to evaluate response to therapy in follow-up bone scans. In patients with lung CA, a positive bone scan will make surgery of the primary lesion inappropriate. For other cancers, a bone scan maybe used if there are other signs, whether clinical or chemical, indicating bone involvement. In patients with GIT, liver, skin, brain or bladder CA, routine bone scanning may be considered superfluous. For patients with suspected infection, a 3-phase bone scan is more desirable. In patients with septic arthritis, the bones of each side of the joint take up the radiopharmaceutical while in patients with cellulitis without while in patients with cellulitis without bony involvement, only the first two phases (dynamic and bloodpool images) will be abnormal. Bone scanning is also used in avascular lesions such as Legg-calve-Perthes disease where one will see reduced uptake of Tc99m MDP. The advent of SPECT imaging has greatly increased the sensitivity in diagnosing AVN. (author)

262

MRI of degenerative bone marrow lesions in experimental osteoarthritis of canine knee joints  

International Nuclear Information System (INIS)

Objective. The objective of this study was to determine the value of MRI in the detection of degenerative bone marrow abnormalities in an animal osteoarthritis model. Design. In 10 dogs with experimentally induced unilateral osteoarthritis of the knee, MRI was performed using two-dimensional spin-echo (2D-SE) and three-dimensional gradient-echo (3D-GE) imaging. Contrast enhanced T1-weighted 2D-SE sequences were also obtained after injection of gadolinium-DTPA. The results were compared with the gross and histopathologic findings and with radiography. Results. Histopathologic specimens revealed 21 osteosclerotic lesions and 5 intraosseous cysts. On 2D-SE images, 24 of 26 lesions were detected, while 21 of 26 lesions were identified on 2D-GE sequences. Radiography, including conventional tomography, demonstrated 9 of 26 lesions. Regardless of the sequence weighting, all osteosclerotic lesions appeared hypointense on MRI. Signal loss in bone sclerosis resulted primarily from the reduction of intact fat marrow, the increased bone density being of secondary importance. Quantitative signal analysis allowed approximate estimation of the grade of sclerosis. On postcontrast images, sclerotic bone remained hypointense, although significant but non-specific enhancement relative to the normal fat marrow was observed. The extent of contrast enhancement did not correlate with the grade of osteosclerosis. All five cysts were readily diagnosed by MRI. Cysts displayed either central od by MRI. Cysts displayed either central or marginal contrast enhancement within their cavities. Conclusions. MRI provides a sensitive method for the diagnosis of osteoarthritic bone abnormalities, allowing their differentiation from most non-degenerative subarticular lesions. (orig.). With 1 tab

263

Oxytocin and bone.  

Science.gov (United States)

One of the most meaningful results recently achieved in bone research has been to reveal that the pituitary hormones have profound effect on bone, so that the pituitary-bone axis has become one of the major topics in skeletal physiology. Here, we discuss the relevant evidence about the posterior pituitary hormone oxytocin (OT), previously thought to exclusively regulate parturition and breastfeeding, which has recently been established to directly regulate bone mass. Both osteoblasts and osteoclasts express OT receptors (OTR), whose stimulation enhances bone mass. Consistent with this, mice deficient in OT or OTR display profoundly impaired bone formation. In contrast, bone resorption remains unaffected in OT deficiency because, even while OT stimulates the genesis of osteoclasts, it inhibits their resorptive function. Furthermore, in addition to its origin from the pituitary, OT is also produced by bone marrow osteoblasts acting as paracrine-autocrine regulator of bone formation modulated by estrogens. In turn, the power of estrogen to increase bone mass is OTR-dependent. Therefore, OTR(-/-) mice injected with 17?-estradiol do not show any effects on bone formation parameters, while the same treatment increases bone mass in wild-type mice. These findings together provide evidence for an anabolic action of OT in regulating bone mass and suggest that bone marrow OT may enhance the bone-forming action of estrogen through an autocrine circuit. This established new physiological role for OT in the maintenance of skeletal integrity further suggests the potential use of this hormone for the treatment of osteoporosis. PMID:25209411

Colaianni, Graziana; Sun, Li; Zaidi, Mone; Zallone, Alberta

2014-10-15

264

RIMS: An Integrated Mapping and Analysis System with Applications to Earth Sciences and Hydrology  

Science.gov (United States)

A web-based information and computational system for analysis of spatially distributed Earth system, climate, and hydrologic data have been developed. The System allows visualization, data exploration, querying, manipulation and arbitrary calculations with any loaded gridded or vector polygon dataset. The system's acronym, RIMS, stands for its core functionality as a Rapid Integrated Mapping System. The system can be deployed for a Global scale projects as well as for regional hydrology and climatology studies. In particular, the Water Systems Analysis Group of the University of New Hampshire developed the global and regional (Northern Eurasia, pan-Arctic) versions of the system with different map projections and specific data. The system has demonstrated its potential for applications in other fields of Earth sciences and education. The key Web server/client components of the framework include (a) a visualization engine built on Open Source libraries (GDAL, PROJ.4, etc.) that are utilized in a MapServer; (b) multi-level data querying tools built on XML server-client communication protocols that allow downloading map data on-the-fly to a client web browser; and (c) data manipulation and grid cell level calculation tools that mimic desktop GIS software functionality via a web interface. Server side data management of the system is designed around a simple database of dataset metadata facilitating mounting of new data to the system and maintaining existing data in an easy manner. RIMS contains "built-in" river network data that allows for query of upstream areas on-demand which can be used for spatial data aggregation and analysis of sub-basin areas. RIMS is an ongoing effort and currently being used to serve a number of websites hosting a suite of hydrologic, environmental and other GIS data.

Proussevitch, A. A.; Glidden, S.; Shiklomanov, A. I.; Lammers, R. B.

2011-12-01

265

Carpal bone analysis in bone age assessment  

Science.gov (United States)

A computer-aided-diagnosis (CAD) method has been previously developed in our Laboratory based on features extracted from regions of interest (ROI) in phalanges in a digital hand atlas. Due to various factors, including, the diversity of size, shape and orientation of carpal bones, non-uniformity of soft tissue, low contrast between the bony structure and soft tissue, the automatic identification and segmentation of bone boundaries is an extremely challenging task. Past research work on carpal bone segmentation has been done utilizing dynamic thresholding. However, due to the discrepancy of carpal bones developments and the limitations of segmentation algorithms, carpal bone ROI has not been taken into consideration in the bone age assessment procedure. In this paper, we present a method for fully automatic carpal bone segmentation and feature analysis in hand X-ray radiograph. The purpose of this paper is to automatically segment the carpal bones by anisotropic diffusion and Canny edge detection techniques. By adding their respective features extracted from carpal bones ROI to the phalangeal ROI feature space, the accuracy of bone age assessment can be improved especially when the image processing in the phalangeal ROI fails in younger children.

Zhang, Aifeng; Gertych, Arkadiusz; Kurkowska-Pospiech, Sylwia; Liu, Brent J.; Huang, H. K.

2006-03-01

266

Thickness of the rim of an expanding lamella near the splash threshold  

OpenAIRE

The evolution of the ejected liquid sheet, or lamella, created after impact of a liquid drop onto a solid surface is studied using high-speed video in order to observe the detailed time evolution of the thickness of the rim of the lamella. Since it has been suggested that splashing behavior is set at very early times after impact, we study early times up to D-0/U-0, where D-0 and U-0 are the diameter and speed of the impacting drop, respectively, for different liquid viscosities and impact sp...

Ruiter, J.; Pepper, R. E.; Stone, H. A.

2010-01-01

267

Search for triggered star formation in the unique bright rimmed cloud 4  

Science.gov (United States)

In order to further our understanding of the radiation driven implosion (RDI) processes and provide an observational feedback to the theoretical modelling of these processes for a wide range of parameters, we propose to search for and study triggered star formation in the highly under-pressured with respect to its ionized boundary layer and one of the smallest among the known cataloged bright rimmed clouds (BRCs), BRC 4. The data and science analyses similar to those applied in our study of the BRC 38 (= IC 1396N) will be employed.

Garmire, Gordon

2007-09-01

268

Wake Flow Simulations for a Mid-Sized Rim Driven Wind Turbine  

Energy Technology Data Exchange (ETDEWEB)

The onshore land where wind farms with conventional wind turbines can be places is limited by various factors including a requirement for relatively high wind speed for turbines' efficient operations. Where such a requirement cannot be met, mid-and small-sized turbines can be a solution. In the current paper simulations for near and for wakes behind a mid-sized Rim Driven Wind Turbine developed by Keuka Energy LLC is analyzed. The purposes of this study is to better understand the wake structure for more efficient wind farm planning. Simulations are conducted with the commercial CFD software STARCCM+

Rob O. Hovsapian; Various

2014-06-01

269

Tumor misto do rim com estrutura de Miosarcoma Mipernefroma e blastema renal em individuo adulto  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O A. descreve um caso de turmor misto do rim, em indivíduo do sexo masculino, com 58 anos de idade. A doença teve evolução lenta, somente sendo suspeitada, quando atingiu a fase final. O exame necroscópico revelou a existência de volumoso tumor do rim direito, apresentando forma bosselada, medindo 1 [...] 9 x 10 x 10 cm e pesando 940 g. A massa tumoral destrói quase completamente a estrutura renal, desta pouca restando reconhecivel. Fora do rim, encontra-se tambem tecido blastomatoso no figado, nos gânglios linfáticos mesentéricos, no peritônio e no epiploon. A estrutura do tumor, observada nos cortes histológicos, é variavel conforme o tecido examinado: no rim hipernefroma; fígado, gãnglios linfáticos, nos nódulos do peritônio e do epiploon, sarcoma mioblástico; em alguns gânglios do mesentério, alem da estrutura de sarcoma mioblástico, existe tecido nefrógeno, representado por formações pouco numerosas, constituidas por túbulos epiteliais, reproduzindo a estrutura de túbulo urinífero. casos desta natureza teem sido referidos com particular raridade, muito se aproximando o caso estudado do descrito por CHEVREL-BODIN e MARUELLE. Abstract in english The A. describes a case of mixed tumor of the kidney in a 58-year-old male individual. The disease underwent a slow evolution, only being suspected when it attained its final stage. The post mortem examination revealed the presence of a bulky tumor of the right kidney, of a bosselated surface, measu [...] ring 19 x 10 x 10 cms. and 940 grs. in weigtht. The tumoral mass destroys the whole kidney structure, of which but very little of recognizable tissue is left. Outside the kidney, blastomatous tissue is also met with in the liver, mesenteric lymphatic glands, peritoneum and apiploon. The tumor structura observed on histological section, varies in conformity with the tissue examined: hipernephroma in the kidney; myoblastic sarcoma in the liver, lymphatic glands, nodules of the peritoneum and epiploon; in some mesenteric glands, apart from the myoblasto-sarcomatous structure, there is nephrogenic tissue, represented by infrequent formations made up epithelial tubules reproducing the structure of uriniferous tubules. Cases of such a feature have been reported as being of particular rarity, and the case here studied approaches very much that described by CHEVREL-BODIN and MARUELLE.

A. Penna de, Azevedo.

270

Technical Efficiency and Port Competition: Revisiting the Bohai Economic Rim, China  

Directory of Open Access Journals (Sweden)

Full Text Available The Bohai Economic Rim plays an important role in supporting China’s economic growth. For this research, we selected nine main ports in the region to study whether intra-port competition or corporatization would improve efficiency. Using a panel fixed effect model and stochastic frontier model, we found that the technical efficiency of selected ports is significantly influenced by the time of the initial public offering than by regional competition. The results are supportive and encouraging for policy makers to move toward the decentralized port governance in China.

Grace Wang

2012-12-01

271

Lower-rim ferrocenyl substituted calixarenes: new electrochemical sensors for anions  

OpenAIRE

New ferrocene substituted calix[4 and 5]arenes have been prepared and the crystal structure of a lower-rim substituted bis ferrocene calix[4]arene (7) has been elucidated. The respective ferrocene/ferrocenium redox-couples of compounds 6 (a calix[4]arene tetra ferrocene amide) and 8 (a calix[5]arene pentaferrocene amide) are shown to be significantly cathodically perturbed in the presence of anions by up to 160 mV in the presence of dihydrogen phosphate. © 1998 Elsevier Science Ltd. All righ...

Gale, Pa; Chen, Z.; Drew, Mgb; Heath, Ja; Beer, Pd

1998-01-01

272

Synthesis and characterization of partially substituted at lower rim phosphorus containing calix(4)arenes  

OpenAIRE

Abstract Abstract: We report the synthesis and characterization of several new phosphorus-containing partially lower rim substituted derivatives of 5,11,17,23-tetra(t-butyl) calix(4)arene (I) and 5,11,17,23-tetra(t-octyl)calix(4)arene (II), namely 5,11,17,23-tetra(t-butyl)-25,27-dihydroxy-26,28-bis(diphenyl phosphinoyl-oxy) calix(4)arene (IV); 5,11,17,23-tetra(t-butyl)-25-hydroxy-26,27,28-tris(tetramethyldiamido-phosphinoyl-oxy) calix(4)arene (Vb); 5,11,17,23-tetra(t-butyl)-...

2007-01-01

273

Indonesia plans to capture larger share of Pacific Rim coal market  

Energy Technology Data Exchange (ETDEWEB)

The World Bank is funding what could become a major new coal producer in the Pacific Rim area. The Omblin II coal field, located in tropical West Sumatra, Indonesia, has estimated reserves of about 70 million tons of bituminous coal with fairly uniform quality. The feasibility study is being conducted by Norwest Resource Consultants for the government of Indonesia. The Ombilin II project will be the development of a new underground mine and coal preparation facilities. The site is near Sawahlunto in west central Sumatra, only 35 miles south of the equator.

Placha, M.F.; Symonds, D.F.

1986-07-01

274

Blade rim of the centripetal stage of a turbine, preferably for a high-performance steam turbine  

Energy Technology Data Exchange (ETDEWEB)

The blade rim consists of a series of radial blades and one (on one side) or two (on two sides) rows of axial blades, which each form a unit along with the side covers and the rotor wheel. Such a blade rim changes the radial steam stream-in direction under small energy losses, and transfers the axial steam current with a well-balanced speed field to an axial stage connected in series. The basically better efficiency of a centripetal turbine benefits the efficiency of the axial stage and so the whole turbine. The well-balanced speed field in the current to the first axial stage produces hardly any power which might cause vibrations at the blade rim. This becomes even more efficient through the suppression power on the side cover during blade rim rotation. The efficiency of the first axial stage is increased by at least 5% and the length of the rotors and the housings is shortened by the possible reduction of the number of blade rims.

Gundlach, W.; Porochnicki, J.; Prywer, J.; Karewicz, B.; Potapczyk, A.; Zielenow, K.

1975-10-23

275

Spatial-temporal variability of coastline in Bohai Rim based on fractal dimension  

Science.gov (United States)

This paper extracted the spatial distribution of the continental coastline of Bohai Rim utilizing Remote Sensing and GIS spatial analysis techniques, and calculated the fractal dimension of the coastline by boxcounting method, with a time from 1990 to 2010. Moreover, we analyzed the characteristics of spatialtemporal variability of the coastline's length and fractal dimension, the relationship between the large scales length change and fractal dimension change. During the research period, the coastline length of the study area increased progressively and the most significant change in coastline length was found in Tianjin Municipality. Especially after 2000, the coastline length entered a period of rapid growth. In addition, the fractal dimension of the overall coastline of the study area was between the fractal dimensions of the regional coastlines and was close to the maximum fractal dimensions of these regional coastlines. The fractal dimension of the coastline in Bohai Rim was increasing during the research period, large scale project such as ports construction, reduced tortuous degree of the coastline.

Xu, Ning; Gao, Zhiqiang; Ning, Jicai; Liu, Xiangyang

2014-10-01

276

Particle Acceleration and Magnetic Fields: Looking at the Northwestern Rim of RCW 86 with Chandra  

Science.gov (United States)

Non-thermal X-ray emission has been detected from several young shell-type supernova remnants (SNRs), including RX J1713.7-3946, and Vela Jr. These X-rays are believed to be synchrotron radiation from electrons accelerated to TeV energies at the shocks, interacting with the compressed, and possibly amplified, local magnetic field. Observations of gamma-ray emission from several SNRs in the TeV range confirm that particles are being accelerated to energies approaching the knee of the cosmic ray spectrum in these remnants. However, while it is broadly believed that diffusive shock acceleration (DSA) in SNRs produces the bulk of cosmic rays below 1 PeV, we still lack a detailed understanding of the acceleration process and its effects on the the system, such as magnetic field amplification and modifications to hydrodynamic evolution. I will report on our recent observations of the NW rim of SNR RCW 86 with the Chandra X-ray Observatory. This deep look into this SNR allowed us to constrain the magnitude of the post-shock magnetic field in several different regions of the NW rim, where it is significantly amplified relative to the usual ambient fields expected. I will discuss our analysis in detail and comment on how MFA appears to be related to certain characteristics of the SNR shock.

Castro, Daniel

2014-08-01

277

Chandra Observations of the South Rim of G266.2-1.2  

Science.gov (United States)

We present results of a Chandra observation of the south rim of the galactic supernova remnant (SNR) G266.2-1.2. G266.2-1.2 (also known as ``Vela Junior'' and RX J0852-4622) is an apparently young SNR along the line of sight to the Vela SNR. The X-ray spectrum of G266.2-1.2 is dominated by non-thermal emission from the shell of the SNR. This Chandra observation resolves the structure of the nonthermal filament and also explores the morphology of a diffuse feature which is apparently over-abundant in O, Ne, and Mg. We will compare this high-resolution image to the nonthermal filament in the NW rim also observed by Chandra. We will determine the upstream and downstream scale widths of the filament from the image and determine the cut-off frequency of the synchrotron emission from the spectra. The image of the thermal emission will be compared to other known fragments of ejecta in the Vela SNR and we discuss the possibility that this thermal feature is associated with the Vela SNR and not associated with G266.2-1.2.

Plucinsky, Paul P.; Gaetz, T. J.; Slane, P.; Edgar, R. J.

2010-01-01

278

Ultratrace analysis of plutonium in environmental samples by resonance ionization mass spectrometry (RIMS)  

Science.gov (United States)

Plutonium is present in the environment mainly as a result of global fallout from nuclear weapons tests, satellite and reactor accidents as well as releases from nuclear facilities. Sensitive and fast detection methods are required for risk assessment, low-level surveillance of the environment, personnel dose monitoring, studies of biological effects and investigations of the migration behavior of plutonium. Furthermore, the isotopic composition is of interest to get information from what source the plutonium contamination originated. Alpha-spectroscopy is most frequently used for the determination of trace amounts of plutonium in the environment with the disadvantage that the detection sensitivity depends on the half-life of the isotope to be measured and that there are limitations in the isotopic resolution. Conventional mass spectrometry may suffer from isobaric interferences. Therefore, in the last years resonant laser ionization mass spectrometry (RIMS) has been explored as an alternative for ultratrace analysis of plutonium. This method provides a high element and isotope selectivity and a good overall efficiency, resulting in a detection limit of ˜106 atoms (˜0.4 fg). RIMS meets also the requirements of a low background and a short measuring time (1-2 h).

Trautmann, N.; Erdmann, N.; Grüning, C.; Kratz, J. V.; Waldek, A.; Huber, G.; Nunnemann, M.; Passler, G.

2000-07-01

279

Analysis of physical processes affecting restructuring of UO2 fuel in Rim-zone  

International Nuclear Information System (INIS)

The purpose of the presented paper is the analysis of the processes affecting so-called 'rim-zone' formation in UO2 and the development of the model describing isotope content profiles at extended burnup. The influence of rim-zone and extended burnup on fuel temperatures is also considered. A brief review of the worldwide models for fission rate and isotope content profiles at extended burnup is given. In this frame, a new model for for prediction of radial profiles of burnup, fission rate and plutonium isotopes have been developed in the TRINITY (Russia). The results from the comparison of the model predictions with experimental data show that the model has good predictability. A new model describing the conditions of dislocation loop nucleation from interstitial atom clusters on fission spikes is also proposed in this paper. The results of the model show that the fuel grain diameter significantly affects the concentration of point defects and dislocation loops. The paper presents the results from the RTOP code calculations of fuel temperature, taking into account non-uniform fission rate and thermal conductivity degradation as result of burnup increasing

280

Sensitivity of LES results from turbine rim seals to changes in grid resolution and sector size  

Science.gov (United States)

Large-Eddy Simulations (LES) were carried out for a turbine rim seal and the sensitivity of the results to changes in grid resolution and the size of the computational domain are investigated. Ingestion of hot annulus gas into the rotor-stator cavity is compared between LES results and against experiments and Unsteady Reynolds-Averaged Navier-Stokes (URANS) calculations. The LES calculations show greater ingestion than the URANS calculation and show better agreement with experiments. Increased grid resolution shows a small improvement in ingestion predictions whereas increasing the sector model size has little effect on the results. The contrast between the different CFD models is most stark in the inner cavity, where the URANS shows almost no ingestion. Particular attention is also paid to the presence of low frequency oscillations in the disc cavity. URANS calculations show such low frequency oscillations at different frequencies than the LES. The oscillations also take a very long time to develop in the LES. The results show that the difficult problem of estimating ingestion through rim seals could be overcome by using LES but that the computational requirements were still restrictive.

O'Mahoney, T.; Hills, N.; Chew, J.

2012-07-01

281

Candida glabrata endophthalmitis following penetrating keratoplasty in a patient with negative donor rim culture  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Candida glabrata endophthalmitis following keratoplasty is rare and almost always associated with positive donor rim culture. Case presentation A 63-year-old patient, diagnosed Fuch's endothelial dystrophy in both eyes underwent a penetrating keratoplasty in his right eye. He had multiple underlying medical problems, which included diabetes mellitus, hypertension, hypoadrenalism on oral dexamethasone and fatty liver secondary to hypertrigliseridemia. He developed multiple suture abscesses, corneal haziness, retrocorneal white plaques and a level of hypopyon two weeks after an uneventful penetrating keratoplasty in his right eye. Cultures of the donor button and the transport media culture were negative. Candida glabrata was isolated successfully from the aqueous and vitreous taps. He was treated with a combination of topical, intracameral, intravitreal and intravenous Amphotericin B. His final visual acuity remained poor due to the haziness of the corneal button. Conclusion Candida glabrata endophthalmitis following penetrating keratoplasty can occur in negative donor rim and transport media cultures. The growth of the organism is facilitated by the patient's immunocompromised status. Awareness by the ophthalmologists and appropriate choice of antibiotics are mandatory in this challenging condition.

Ibrahim Mohtar

2010-06-01

282

A Radio and Mid-Infrared Survey of Northern Bright-Rimmed Clouds  

CERN Document Server

We have carried out an archival radio, optical and infrared wavelength imaging survey of 44 Bright-Rimmed Clouds (BRCs) using the NRAO/VLA Sky Survey (NVSS) archive, images from the Digitised Sky Survey (DSS) and the Midcourse Space eXperiment (MSX). The data characterise the physical properties of the Ionised Boundary Layer (IBL) of the BRCs. A total of 25 clouds display 20 cm radio continuum emission that is associated with their bright optical rims. The ionising photon flux illuminating these clouds, the ionised gas pressure and the electron density of the IBL are determined. We derive internal molecular pressures for 9 clouds using molecular line data from the literature and compare these pressures to the IBL pressures to determine the pressure balance of the clouds. We find three clouds in which the pressure exerted by their IBLs is much greater than that measured in the internal molecular material. A comparison of external pressures around the remaining clouds to a global mean internal pressure shows th...

Morgan, L K; Urquhart, J S; Miao, G J; Miao, Glenn.J.White & J.

2001-01-01

283

Detection of submicron rim growth on zircon using ion microprobe U-Pb age depth profiling  

Science.gov (United States)

The rims of zircon commonly preserve crucial U-Pb age information for deciphering thermotectonic events in orogenic crust. In many cases, the rims recording the last phase of zircon growth are < 1 micron and are hence difficult or impossible to analyze using conventional methods, including ion probe spot analyses. In the migmatitic core of the Valhalla gneiss dome complex of British Columbia, rocks were variably affected by a partial melting and deformation event at 60-50 Ma. Some leucosomes in migmatites with variable melt fraction (5-30 percent) yield 60-50 Ma zircon and monazite U-Pb and Th-Pb ages that constrain when partial melting, extension, and exhumation of the dome occurred. In contrast, zircons from a granodiorite gneiss in the core of the dome contain no easily accessed record of the Eocene event and instead record its 100 Ma emplacement age. To enhance our ability to resolve the Eocene event, we performed "ion drilling" into zircon crystal faces to measure U-Pb age depth profiles with <100 nm spatial resolution with a CAMECA 1270 ion microprobe. Zircon was analyzed from 3 samples: leucosome from a stromatic migmatite, leucosome crystallized in a boudin neck, and the granodiorite gneiss. The stromatic leucosome yielded a consistent age of ca. 51 Ma over 4 microns. Previous conventional spot analyses of the same grains (analyzed in polished grain mounts) showed ages from ca. 450 Ma to ca. 52.5 Ma. In the case of the boudin neck, previous spot analyses of zircon had yielded concordant ages of 62 and 59 Ma; however, with the depth profiling technique, most grain rims yielded age gradients from ca. 42 Ma to ca. 60 Ma over the outermost 1-2 microns of the crystals. Zircons from the ca. 100 Ma granodiorite gneiss revealed very high U (to 99805 ppm) rims developed over the outer 100-250 nm. Below the high U rim, the grains record ages that increased from ca. 50 to 90 Ma within the first 0.5 microns of the crystal face. The outermost high-U regions yielded very young and geologically unrealistic U-Pb ages (ca. 26 Ma) that directly correlate with U content and appear to reflect Pb loss. Even though the 3 samples are petrologically and structurally distinct, and represent different structural locations in the dome, all reveal some evidence for an Eocene thermotectonic event. Our results demonstrate the utility of the high- resolution, depth profiling capability of the ion microprobe, and its complementary role to conventional SIMS, LAICPMS, and TIMS U-Pb analyses. In some instances it may represent the only method capable of resolving crucial U-Pb age information preserved at the submicron scale at the outermost surfaces of zircon.

Gordon, S. M.; Grove, M.; Whitney, D. L.; Teyssier, C.

2006-12-01

284

The RIM101/pacC Homologue from the Basidiomycete Ustilago maydis Is Functional in Multiple pH-Sensitive Phenomena  

OpenAIRE

A homologue of the gene encoding the transcription factor Rim101 (PacC), involved in pH signal transduction in fungi, was identified in the pathogenic basidiomycete Ustilago maydis. The gene (RIM101) encodes a protein of 827 amino acid residues, which shows highest similarity to PacC proteins from Fusarium oxysporum and Aspergillus niger. The gene had the capacity to restore protease activity to rim101 mutants from Yarrowia lipolytica, confirming its homologous function, and was expressed at ...

Are?chiga-carvajal, Elva T.; Ruiz-herrera, Jose?

2005-01-01

285

Primary Rosai-Dorfman disease of bone: a clinicopathologic study of 15 cases.  

Science.gov (United States)

Sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disorder of unknown etiology. Most patients present with lymph node involvement manifesting as adenopathy; however, RDD may arise primarily in a variety of extranodal sites, including bone. We report herein our experience with 15 cases of primary intraosseous RDD. The patients include 8 females and 7 males, who ranged in age from 3 to 56 (mean 27) years. The lesions arose in a variety of anatomical locations, including the tibia, femur, clavicle, skull, maxilla, calcaneus, phalanx, metacarpal, and sacrum. Radiographically, the lesions were lytic with well defined and usually sclerotic margins. Histologically, the lesions demonstrated the classic features of RDD and consisted of a mixed inflammatory infiltrate with numerous large histiocytes with abundant eosinophilic cytoplasm which exhibited emperipolesis. Some cases also contained numerous neutrophils. Immunohistochemical stains showed that the large histiocytes were S-100 positive. Follow-up information was available for 12 patients. Five patients eventually developed additional extraosseous manifestations, including testicular, lymph node, and subcutaneous lesions. One of these 5 also developed a new bony lesion within the sternum. One patient developed additional lesions within multiple bones of the hand and wrist, without extraosseous disease. One patient had stable bony lesions, whereas 5 remained disease free after treatment. PMID:20679880

Demicco, Elizabeth G; Rosenberg, Andrew E; Björnsson, Johannes; Rybak, Leon D; Unni, K Krishnan; Nielsen, G Petur

2010-09-01

286

Regeneration of Mastoid Air Cells in Vivo Using Autologous Cortical Bone  

Directory of Open Access Journals (Sweden)

Full Text Available Purpose: This was a preliminary study to assess surgical construction and regeneration of mastoid air cells in the treatment of cholesteatoma. Methods: Two-stage tympanoplasty with mastoidectomy was performed in four cases of unilateral cholesteatoma with sclerotic mastoid. During the first-stage operation, small fragments of autologous cortical bone were inserted into the cavity after mastoidectomy to form a honeycomb-like structure. Reconstruction of the lateral wall of the mastoid cavity was performed using the mastoid cortical bony plate. Pre- and postoperative mastoid volume was evaluated by three-dimensional reconstruction based on high-resolution computed tomography (HR-CT images. Results: HR-CT images after the first-stage operation showed that mastoid volume had increased in all subjects. Macroscopic inspection during the second-stage operation revealed that the honeycomb-like structure made of bony fragments and covered by thin mucosa in the mastoid cavity was stable, with no evidence of effusion or granulation tissue. No retraction of the eardrum, middle ear effusion or recurrence of cholesteatoma was observed, and the hearing level on a pure-tone audiogram was improved in any subject 60 - 94 months after the second-stage operation. Conclusion: Surgical construction and regeneration of mastoid air cells using autologous cortical bone can be useful in treatment of cholesteatoma with arrested mastoid pneumatization.

Ken-ichi Kaneko

2012-11-01

287

Bone Builders: The Science of Grafts, Biomaterials and Bone Engineering  

Science.gov (United States)

FASEB Breakthroughs in Bioscience article. Every year, more than 800,000 people in the United States receive bone biomaterials, including bone grafts and bone graft substitutes. Bone is the most commonly transplanted tissue after blood transfusions. Unlike most tissues, bone is able to regenerate and reform without scarring, given the proper conditions and materials. Researchers and scientists have learned to exploit this property over many centuries to create modern day bone grafts and bone biomaterials used as substitutes for bone grafts.

Steven Stocker (x)

2009-07-22

288

JAMA Patient Page: Bone Fractures  

Science.gov (United States)

... the American Medical Association JAMA PATIENT PAGE Bone Fractures A bone fracture is a break in a ... below) to treat bone fractures. CAUSES OF BONE FRACTURES FOR MORE INFORMATION • American Academy of Orthopaedic Surgeons ...

289

Bone fragility and imaging techniques  

OpenAIRE

Bone fragility is a silent condition that increases bone fracture risk, enhanced by low bone mass and microarchitecture deterioration of bone tissue that lead to osteoporosis. Fragility fractures are the major clinical manifestation of osteoporosis.

D’elia, Giovanni; Caracchini, Giuseppe; Cavalli, Loredana; Innocenti, Paolo

2009-01-01

290

Enfermedad de Paget en Chile: una serie de 15 pacientes / Paget disease of bone: Report of 15 cases  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish [...] Abstract in english Background: Paget disease of bone (PD) is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and m [...] ethods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained data from 15 patients with PD (ten males, eight Chilean, six European and one Asian), eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit). Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Méd Chile 2003; 131: 491-7).

Gilberto, González V; Francisca, Brusco G; Eugenio, Arteaga U; José, Rodríguez P; Sergio, Jacobelli G; Loreto, Massardo V; Cristián, Ortiz M; Oscar, Contreras O.

2003-05-01

291

Enfermedad de Paget en Chile: una serie de 15 pacientes Paget disease of bone: Report of 15 cases  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Paget disease of bone (PD is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and methods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained data from 15 patients with PD (ten males, eight Chilean, six European and one Asian, eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit. Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Méd Chile 2003; 131: 491-7.

Gilberto González V

2003-05-01

292

Bone marrow imaging  

International Nuclear Information System (INIS)

Bone marrow imaging is of limited value in most patients with hematologic disorders. Frequently marrow aspirate or biopsy can reveal detailed information for accurate diagnosis. However in patients with nonuniform marrow distribution bone marrow imaging may be of considerable help in localizing the diseased sites for marrow sampling. Marrow scintigraphy in conjunction with bone imaging has been used in the evaluation of bone and joint complaints in patients with sickle cell disorders. Marrow scanning with Fe-52 has been utilized in the investigation of mass lesions that may represent extramedullary hematopoiesis. Bone marrow imaging is of limited value in the metastatic workup of patients with malignancy. This paper discusses how bone marrow scanning is useful in evaluating the distribution of active marrow in various hematologic disorders. It is also useful in evaluation of the complications of these disorders. It may be used, in conjunction with bone imaging, to aid in the differential diagnosis of bone pain in patients with predisposition to marrow infarction

293

Bone mineral density test  

Science.gov (United States)

BMD test; Bone density test; Bone densitometry; DEXA scan; DXA; Dual-energy x-ray absorptiometry; p-DEXA; Osteoporosis-BMD ... need to undress. This scan is the best test to predict your risk of fractures. Peripheral DEXA ( ...

294

Smoking and Bone Health  

Science.gov (United States)

... supported by your browser. Home Bone Basics Lifestyle Smoking and Bone Health Publication available in: PDF (217 ... Overtraining Risks for Women Oral Health Partner Resources Smoking: It’s Never Too Late to Stop (NIA)

295

Magnetic resonance imaging of bone marrow changes in Gaucher disease during enzyme replacement therapy: first German long-term results  

International Nuclear Information System (INIS)

Objective:. Since 1991, enzyme replacement therapy (ERT) has been available for patients with Gaucher disease in Germany. The aim of this study was to analyse the MR pattern of bone marrow involvement and response to ERT in Gaucher disease type I. Patients and design:. Thirty patients with Gaucher disease type I had MRI examinations prior to initiation of ERT with alglucerase/imiglucerase and during follow-up. Median MR follow-up and duration of ERT were 36 months. Coronal T1- and T2-weighted spin-echo images of the lower extremities were obtained to evaluate changes in the appearance of yellow marrow. MR images were categorized as having either a homogeneous (type A) or non-homogeneous patchy (type B) appearance of bone involvement and response to ERT was assessed by two radiologists. Results:. Overall, 19 of 30 patients (63%) showed an increased signal intensity on T1- and T2-weighted images after 36 months of ERT, consistent with partial reconversion of fatty marrow during treatment. Focal bone lesions surrounded by a low signal intensity (SI) rim did not respond to ERT, suggesting bone infarcts. Of the 11 patients with bone infarcts (low SI rim lesion), 82% had the non-homogeneous type B pattern (P=0.0021). In 86% of patients with splenectomy, bone infarcts were seen (P<0.05). Conclusions:. MRI using T1- and T2-weighted spin-echo sequences is a valuable, non-invasive method for monitoring bone marrow response in patients receiving ERT. A non- homogeneous patchy sieceiving ERT. A non- homogeneous patchy signal intensity of bone marrow involvement correlates with the presence of bone infarcts (P=0.0021). (orig.)

296

Magnetic resonance imaging of bone marrow changes in Gaucher disease during enzyme replacement therapy: first German long-term results  

Energy Technology Data Exchange (ETDEWEB)

Objective:. Since 1991, enzyme replacement therapy (ERT) has been available for patients with Gaucher disease in Germany. The aim of this study was to analyse the MR pattern of bone marrow involvement and response to ERT in Gaucher disease type I. Patients and design:. Thirty patients with Gaucher disease type I had MRI examinations prior to initiation of ERT with alglucerase/imiglucerase and during follow-up. Median MR follow-up and duration of ERT were 36 months. Coronal T1- and T2-weighted spin-echo images of the lower extremities were obtained to evaluate changes in the appearance of yellow marrow. MR images were categorized as having either a homogeneous (type A) or non-homogeneous patchy (type B) appearance of bone involvement and response to ERT was assessed by two radiologists. Results:. Overall, 19 of 30 patients (63%) showed an increased signal intensity on T1- and T2-weighted images after 36 months of ERT, consistent with partial reconversion of fatty marrow during treatment. Focal bone lesions surrounded by a low signal intensity (SI) rim did not respond to ERT, suggesting bone infarcts. Of the 11 patients with bone infarcts (low SI rim lesion), 82% had the non-homogeneous type B pattern (P=0.0021). In 86% of patients with splenectomy, bone infarcts were seen (P<0.05). Conclusions:. MRI using T1- and T2-weighted spin-echo sequences is a valuable, non-invasive method for monitoring bone marrow response in patients receiving ERT. A non- homogeneous patchy signal intensity of bone marrow involvement correlates with the presence of bone infarcts (P=0.0021). (orig.)

Poll, L.W.; Koch, J.A.; Scherer, A.; Boerner, D.; Moedder, U. [Duesseldorf Univ. (Germany). Inst. fuer Diagnostische Radiologie; Dahl, S. vom; Niederau, C.; Haeussinger, D. [Duesseldorf Univ. (Germany). Medizinische Fakultaet; Willers, R. [Duesseldorf Univ. (Germany). Rechenzentrum

2001-09-01

297

Comparative imaging study for soft tissue changes in osteomyelitis and malignant bone tumor  

International Nuclear Information System (INIS)

Objective: To investigate the value of the imaging findings of soft tissue abnormality in the differential diagnosis between osteomyelitis and malignant bone tumor. Methods: The CT and MRI findings of soft tissue changes in 57 cases of osteomyelitis and 70 cases of malignant bone tumor were retrospectively defined,observed, recorded and statistically analyzed. Results: In 57 cases of osteomyelitis, 54 cases were examined with CT, and soft tissue swelling was presented in 52 cases (degree I in 19 cases, degree II in 16 cases, degree III in 17 cases). Abscess-like cysts in soft tissue occurred in 6 cases, masses in 5, air in 1, fat-fluid level in 1 and sinus tract in 1. Among 14 cases examined with MR imaging, soft tissue swelling was presented in all cases (degree I in 2 cases, degree II in 6 cases and degree III in 6 cases). Abscess-like cysts appeared in 3 cases and showed high signal in diffusion weighted imaging, mass in 1 and fat-fluid level in 1. Among 54 cases examined with CT in 70 cases of malignant bone tumor, soft tissue swelling was presented in 44 cases (degree I in 29 cases, degree II in 12 cases, degree III in 3 cases). Soft tissue masses appeared in 49 cases, bone shell and shell-like calcification in 16 cases, and neoplastic bone and neoplastic calcified cartilage within soft tissue mass in 25 cases. Among 49 cases examined with MR imaging, soft tissue swelling was presented in 46 cases (degree I in 21 cases, degree II in 17 cases and degree III in 8 cegree II in 17 cases and degree III in 8 cases), and soft tissue masses appeared in 43 cases. The degree of soft tissue swelling and the occurrence of abscess-like cyst, mass, bone shell or shell-liked calcification in the rim of mass, neoplastic bone or neoplastic calcified cartilage in masses showed significant difference (P<0.05) between osteomyelitis group and malignant bone tumor group on CT examination. The degree of Soft tissue swelling and the occurrence frequency of abscess-like cysts and mass were significantly different (P<0.05) between osteomyelitis group and malignant bone tumor group on MR examination. Conclusion: The degree of soft tissue swelling and the presence of mass were valuable for the differential diagnosis. Bone shell or shell-liked calcification in the rim of mass and neoplastic bone or neoplastic calcified cartilage were specific imaging signs of malignant bone tumor. Abscess-like cysts, soft tissue air, fat-fluid level and sinus tract were specific signs of osteomyelitis. (authors)

298

Small Animal Bone Biomechanics  

OpenAIRE

Animal models, in particular mice, offer the possibility of naturally achieving or genetically engineering a skeletal phenotype associated with disease and conducting destructive fracture tests on bone to determine the resulting change in bone’s mechanical properties. Several recent developments, including nano- and micro- indentation testing, microtensile and microcompressive testing, and bending tests on notched whole bone specimens, offer the possibility to mechanically probe small anima...

Vashishth, Deepak

2008-01-01

299

Radionuclide bone imaging  

Energy Technology Data Exchange (ETDEWEB)

Radionuclide bone imaging of the skeleton, now well established as the most important diagnostic procedure in detecting bone metastases, is also a reliable method for the evaluation of the progression or regression of metastatic bone disease. The article concentrates on the technetium-99m agents and the value of these agents in the widespread application of low-dose radioisotope scanning in such bone diseases as metastasis, osteomyelitis, trauma, osteonecrosis, and other abnormal skeletal conditions.

Bassett, L.W.; Gold, R.H.; Webber, M.M.

1981-12-01

300

Radionuclide bone imaging  

International Nuclear Information System (INIS)

Radionuclide bone imaging of the skeleton, now well established as the most important diagnostic procedure in detecting bone metastases, is also a reliable method for the evaluation of the progression or regression of metastatic bone disease. The article concentrates on the technetium-99m agents and the value of these agents in the widespread application of low-dose radioisotope scanning in such bone diseases as metastasis, osteomyelitis, trauma, osteonecrosis, and other abnormal skeletal conditions

301

Temporal Bone Meningiomas  

OpenAIRE

Meningiomas involving the temporal bone may originate from arachnoid cell nests present within the temporal bone (intratemporal), but more frequently originate from arachnoid cell nests of the posterior or middle cranial fossa with secondary invasion of the TB (extratemporal). In this study, we retrospectively reviewed the charts of 13 patients with meningiomas involving the temporal bone who underwent surgery. Tumors of the posterior fossa with only temporal bone hyperostosis, but without in...

Vrionis, Fotios D.; Robertson, Jon H.; Gardner, Gale; Heilman, Carl B.

1999-01-01

302

Gracile bone dysplasias  

International Nuclear Information System (INIS)

Gracile bone dysplasias constitute a group of disorders characterised by extremely slender bones with or without fractures. We report four newborns, two of whom showed multiple fractures. Two babies had osteocraniostenosis and one had features of oligohydramnios sequence. The diagnosis in the fourth newborn, which showed thin long bones and clavicles and extremely thin, poorly ossified ribs, is uncertain. Exact diagnosis of a gracile bone dysplasia is important for genetic counselling and medico-legal reasons. (orig.)

303

Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions  

International Nuclear Information System (INIS)

Aim: The aim of this study is to evaluate the value of the apparent diffusion coefficient (ADC) obtained in diffusion-weighted (DW) MR sequences for the differentiation between malignant and benign bone marrow lesions. Method: Forty-five patients with altered signal intensity vertebral bodies on conventional MR sequences were included. The cause of altered signal intensity was benign osteoporotic collapse in 16, acute neoplastic infiltration in 15, and infectious processes in 14; based on plain-film, CT, bone scintigraphy, conventional MR studies, biopsy or follow-up. All patients underwent isotropic DW MR images (multi-shot EPI, b values of 0 and 500 s/mm2). Signal intensity at DW MR images was evaluated and ADC values were calculated and compared between malignancy, benign edema and infectious spondylitis. Results: Acute malignant fractures were hyperintense compared to normal vertebral bodies on the diffusion-weighted sequence, except in one patient with sclerotic metastases. Mean ADC value from benign edema (1.9 ± 0.39 x 10-3 mm2/s) was significantly (p -3 mm2/s). Mean ADC value of infectious spondilytis (0.96 ± 0.49 x 10-3 mm2/s) was not statistically (p > 0.05) different from untreated metastasic lesions. ADC value was low (0.75 x 10-3 mm2/s) in one case of subacute benign fracture. Conclusions: Aubacute benign fracture. Conclusions: ADC values are a useful complementary tool to characterize bone marrow lesions, in order to distinguish acute benign fractures from malignant or infectious bone lesions. However, ADC values are not valuable in order to differentiate malignancy from infection.

304

Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions  

Energy Technology Data Exchange (ETDEWEB)

Aim: The aim of this study is to evaluate the value of the apparent diffusion coefficient (ADC) obtained in diffusion-weighted (DW) MR sequences for the differentiation between malignant and benign bone marrow lesions. Method: Forty-five patients with altered signal intensity vertebral bodies on conventional MR sequences were included. The cause of altered signal intensity was benign osteoporotic collapse in 16, acute neoplastic infiltration in 15, and infectious processes in 14; based on plain-film, CT, bone scintigraphy, conventional MR studies, biopsy or follow-up. All patients underwent isotropic DW MR images (multi-shot EPI, b values of 0 and 500 s/mm{sup 2}). Signal intensity at DW MR images was evaluated and ADC values were calculated and compared between malignancy, benign edema and infectious spondylitis. Results: Acute malignant fractures were hyperintense compared to normal vertebral bodies on the diffusion-weighted sequence, except in one patient with sclerotic metastases. Mean ADC value from benign edema (1.9 {+-} 0.39 x 10{sup -3} mm{sup 2}/s) was significantly (p < 0.0001) higher than untreated metastasic lesions (0.9 {+-} 1.3 x 10{sup -3} mm{sup 2}/s). Mean ADC value of infectious spondilytis (0.96 {+-} 0.49 x 10{sup -3} mm{sup 2}/s) was not statistically (p > 0.05) different from untreated metastasic lesions. ADC value was low (0.75 x 10{sup -3} mm{sup 2}/s) in one case of subacute benign fracture. Conclusions: ADC values are a useful complementary tool to characterize bone marrow lesions, in order to distinguish acute benign fractures from malignant or infectious bone lesions. However, ADC values are not valuable in order to differentiate malignancy from infection.

Balliu, E. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: eballiu@gmail.com; Vilanova, J.C. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: Kvilanova@comg.es; Pelaez, I. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: isapelaezrx@yahoo.es; Puig, J. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: jpuigalcantara@yahoo.es; Remollo, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sremollo@gmail.com; Barcelo, C. [Department of Computer Science and Applied Mathematics, University of Girona (Spain)], E-mail: carles.barcelo@udg.es; Barcelo, J. [Department of Magnetic Resonance, Clinica Girona, Girona (Spain)], E-mail: rmgirona@comg.es; Pedraza, S. [Department of Magnetic Resonance, IDI Girona, Hospital Universitari de Girona Dr Josep Trueta, Girona (Spain)], E-mail: sapedraza@gmail.com

2009-03-15

305

Rough Design of a Double-Stator Axial Flux Permanent Magnet Generator for a Rim-Driven Marine Current Turbine  

OpenAIRE

This paper deals with the rough design of a Double-Stator Axial Flux Permanent Magnet Machine (DSAFPM) for a rim-driven Marine Current Turbine (MCT). The DSAFPM machine will be compared to a previously developed and realized Radial Flux Permanent Magnet Machine (RFPM); given the same rim-driven MCT specifications. For that purpose, a first-order electromagnetic design model and a thermal one are developed and used to compare active part mass, cost, and thermal behavior of the two machines. Th...

Djebarri, Sofiane; Fre?de?ric Charpentier, Jean; Scuiller, Franck; Benbouzid, Mohamed; Guemard, Sylvain

2012-01-01

306

Functional Coupling of Rab3-interacting Molecule 1 (RIM1) and L-type Ca2+ Channels in Insulin Release*  

OpenAIRE

Insulin release by pancreatic ?-cells is regulated by diverse intracellular signals, including changes in Ca2+ concentration resulting from Ca2+ entry through voltage-gated (CaV) channels. It has been reported that the Rab3 effector RIM1 acts as a functional link between neuronal CaV channels and the machinery for exocytosis. Here, we investigated whether RIM1 regulates recombinant and native L-type CaV channels (that play a key role in hormone secretion) and whether this regulation affects ...

Gandini, Mari?a A.; Sandoval, Alejandro; Gonza?lez-rami?rez, Ricardo; Mori, Yasuo; Waard, Michel; Felix, Ricardo

2011-01-01

307

Menopause and Bone Loss  

Science.gov (United States)

... aT risk for bone loss? Your risk of bone loss is higher if you have a family history of osteoporosis, or if you are • White or asian • thin or have a small frame • taking steroid medications (such as prednisone or cortisone) • eating a diet low in ... bone osteoporosis www.hormone.org Menopause ...

308

Bone marrow biopsy  

Science.gov (United States)

Biopsy - bone marrow ... A bone marrow biopsy may be done in the health care provider's office or in a hospital. The sample may ... This captures a tiny sample, or core, of bone marrow within the needle. The sample and needle are ...

309

What's a Funny Bone?  

Science.gov (United States)

... Main Page The Pink Locker Society What's a Funny Bone? KidsHealth > Kids > Q&A > Q & A > What's a Funny Bone? Print A A A Text Size Have ... or prickly kind of dull pain? That's your funny bone! It doesn't really hurt as much ...

310

Triggered Star Formation and Young Stellar Population in Bright-rimmed Cloud SFO 38  

Science.gov (United States)

We have investigated the young stellar population in and around SFO 38, one of the massive globules located in the northern part of the Galactic H II region IC 1396, using the Spitzer IRAC and MIPS observations (3.6-24 ?m), and followed up with ground-based optical photometric and spectroscopic observations. Based on the IRAC and MIPS colors and H? emission, we identify ~45 young stellar objects (Classes 0/I/II) and 13 probable pre-main-sequence candidates. We derive the spectral types (mostly K- and M-type stars), effective temperatures, and individual extinction of the relatively bright and optically visible Class II objects. Most of the Class II objects show variable H? emission as well as optical and near-infrared photometric variability, which confirm their "youth." Based on optical photometry and theoretical isochrones, we estimate the spread in stellar ages to be between 1 and 8 Myr with a median age of 3 Myr and a mass distribution of 0.3-2.2 M sun with a median value around 0.5 M sun. Using the width of the H? emission line measured at 10% peak intensity, we derive the mass accretion rates of individual objects to be between 10-10 and 10-8 M sun yr-1. From the continuum-subtracted H? line image, we find that the H? emission of the globule is not spatially symmetric with respect to the O-type ionizing star HD 206267, and the interstellar extinction toward the globule is also anomalous. We clearly detect an enhanced concentration of YSOs closer to the southern rim of SFO 38 and identify an evolutionary sequence of YSOs from the rim to the dense core of the cloud, with most of the Class II objects located at the bright rim. The YSOs appear to be aligned along two different directions toward the O6.5V type star HD 206267 and the B0V type star HD 206773. This is consistent with the Radiation Driven Implosion (RDI) model for triggered star formation. Further, the apparent speed of sequential star formation is consistent with the speed of propagation of shocks in dense globules as derived from numerical simulations of RDI.

Choudhury, Rumpa; Mookerjea, Bhaswati; Bhatt, H. C.

2010-07-01

311

SEPARATION OF NEWLY FORMED BONE FROM OLDER COMPACT BONE REVEALS CLEAR COMPOSITIONAL DIFFERENCES IN BONE MATRIX  

OpenAIRE

In long bone diaphyses, woven bone forms first and then transitions into a more mineralized compact bone tissue. Prior evidence suggests that the non-collagenous protein composition of woven bone may be distinct from that of more mature bone tissue, particularly with respect to a diverse group of phosphorylated, extracellular matrix proteins. To critically test this hypothesis, we developed an in situ approach to isolate newly formed bone from more mature bone within the same long bone, and c...

Midura, Ronald J.; Midura, Sharon B.; Su, Xiaowei; Gorski, Jeffrey P.

2011-01-01

312

Usefulness of 18F fluoride PET/CT in breast cancer patients with osteosclerotic bone metastases  

International Nuclear Information System (INIS)

Bone metastasis is an important factor for the treatment and prognosis of breast cancer patients. Whole body bone scintigraphy (WBBS) can evaluate skeletal metastases, and 18F FDG PET/CT seems to exhibit high specificity and accuracy in detecting bone metastases. However, there is a limitation of 18F FDG PET in assessing sclerotic bone metastases because some lesions may be undetectable. Recent studies showed that 18F fluoride PET/CT is more sensitive than WBBS in detecting bone metastases. This study aims to evaluate the usefulness of 18F fluoride PET/CT by comparing it with WBBS and 18F FDG PET/CT in breast cancer patients with osteosclerotic skeletal metastases. Nine breast cancer patients with suspected bone metastases (9 females; mean age ± SD, 55.6±10.0 years) underwent 99mTc MDP WBBS, 18F FDG PET/CT and 18F fluoride PET/CT. Lesion based analysis of five regions of the skeletons(skull, vertebral column, thoracic cage, pelvic bones and long bones of extremities) and patient based analysis were performed. 18F fluoride PET/CT, 18F FDG PET/CT and WBBS detected 49, 20 and 25 true metastases, respectively. Sensitivity, specificity, positive predictive value and negative predictive value of 18F fluoride PET/CT were 94.2%, 46.3%, 57.7% and 91.2%, respectively. Most true metastatic lesions of 18F fluoride PET/CT had osteosclerotic change (oride PET/CT had osteosclerotic change (45/49, 91.8%), and only four lesions showed osteolytic change. Most lesions on 18F FDG PET/CT also demonstrated osteosclerotic change (17/20, 85.0%) with three osteolytic lesions. All true metastatic lesions detected on WBBS and 18F FDG PET/CT were identified on 18F fluoride PET/CT. 18F FDG PET/CT in detecting osteosclerotic metastatic lesions. 18F fluoride PET/CT might be useful in evaluating osteosclerotic metastases in breast cancer patients

313

A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease.  

OpenAIRE

Abstract Background Multiple myeloma is a hematologic malignancy associated with the development of a destructive osteolytic bone disease. Results Mathematical models are developed for normal bone remodeling and for the dysregulated bone remodeling that occurs in myeloma bone disease. The models examine the critical signaling between osteoclasts (bone resorption) and osteoblasts (bone formation). The interactions of osteoclasts and osteoblasts are modeled as a s...

Webb Glenn F; Edwards Claire M; Ayati Bruce P; Wikswo John P

2010-01-01

314

The run-off condition for rimming flow of a power-law fluid  

Energy Technology Data Exchange (ETDEWEB)

The rimming flow of a power-law fluid in the inner surface of a horizontal rotating cylinder is investigated. Exploiting the fact that the liquid layer is thin, the simplest lubrication theory is applied. The generalized run-off condition for the steady-state flow of the power-law liquid is derived. In the bounds implied by this condition, film thickness admits a continuous solution. In the supercritical case when the mass of non-Newtonian liquid exceeds a certain value or the speed of rotation is less than an indicated limit, a discontinuous solution is possible and a hydraulic jump may occur in the steady-state regime. The location and height of the hydraulic jump for the power-law liquid is determined. (orig.)

Fomin, S.; Watterson, J.; Raghunathan, S. [School of Aeronautical Engineering, Queen' s University of Belfast, Belfast (United Kingdom); Harkin-Jones, E. [School of Mechanical and Manufacturing Engineering, Queen' s University of Belfast, Belfast (United Kingdom)

2001-11-01

315

Growth and instability of the liquid rim in the crown splash regime  

CERN Document Server

We study the formation, growth, and disintegration of jets following impact of a drop on a thin film of the same liquid for We < 1000 and Re < 2000 using a combination of numerical simulations and linear stability theory (Agbaglah et al. 2013). Our simulations faithfully capture this phenomena and are in good agreement with experimental profiles obtained from high-speed X-ray imaging.We obtain scaling relations from our simulations and use these as inputs to our stability analysis. The resulting prediction for the most unstable wavelength are in excellent agreement with experimental data. Our calculations show that the dominant destabilizing mechanism is a competition between capillarity and inertia but that deceleration of the rim provides an additional boost to growth. We also predict over the entire parameter range of our study the number and timescale for formation of secondary droplets formed during a splash, based on the assumption that the most unstable mode sets the droplet number.

Agbaglah, G

2014-01-01

316

An Investigation on the Morphological Evolution of Bright-Rimmed Clouds  

CERN Document Server

A new Radiative Driven Implosion (RDI) model based on Smoothed Particle Hydrodynamics (SPH) technique is developed and applied to investigate the morphological evolutions of molecular clouds under the effect of ionising radiation. This model self-consistently includes the self-gravity of the cloud in the hydrodynamical evolution, the UV radiation component in the radiation transfer equations, the relevant heating and cooling mechanisms in the energy evolution and a comprehensive chemical network. The simulation results reveal that under the effect of ionising radiation, a molecular cloud may evolve through different evolutionary sequences. Dependent on its initial gravitational state, the evolution of a molecular cloud does not necessarily follow a complete morphological evolution sequence from type A to B to C, as described by previous RDI models. When confronted with observations, the simulation results provide satisfactory physical explanations for a series of puzzles derived from Bright-Rimmed Clouds (BRC...

Miao, J; Thompson, M A; Nelson, R P

2008-01-01

317

Study of triggered star formation in a bright-rimmed cloud  

Science.gov (United States)

Bright-rimmed clouds (BRCs) are small and dense molecular clouds located in the periphery of the evolved HII regions. The illumination of these dark clumps by nearby OB stars might be responsible for triggered collapse and subsequent star formation through the mechanism known as radiation-driven implosion (RDI). We carried out a multi-wavelength study of a BRC located in the periphery of the evolved HII region G52.85-0.55. From the evaluation of the pressure balance between the ionized gas located at the illuminated border of the clump and the molecular gas, we show that shocks are being driven in the external layers of the BRC. On the other hand the pressure balance suggests that the birth of young stellar objects embedded in the BRC could have been initiated by the RDI mechanism.

Ortega, M. E.; Paron, S.; Giacani, E.; Petriella, A.

2014-10-01

318

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.  

Science.gov (United States)

The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic active zone (AZ) membranes has been studied in detail, and several essential components have been identified. AZ-associated protein scaffolds are viewed as only modulatory for transmission. We discovered that Drosophila Rab3-interacting molecule (RIM)-binding protein (DRBP) is essential not only for the integrity of the AZ scaffold but also for exocytotic neurotransmitter release. Two-color stimulated emission depletion microscopy showed that DRBP surrounds the central Ca(2+) channel field. In drbp mutants, Ca(2+) channel clustering and Ca(2+) influx were impaired, and synaptic release probability was drastically reduced. Our data identify RBP family proteins as prime effectors of the AZ scaffold that are essential for the coupling of SVs, Ca(2+) channels, and the SV fusion machinery. PMID:22174254

Liu, Karen S Y; Siebert, Matthias; Mertel, Sara; Knoche, Elena; Wegener, Stephanie; Wichmann, Carolin; Matkovic, Tanja; Muhammad, Karzan; Depner, Harald; Mettke, Christoph; Bückers, Johanna; Hell, Stefan W; Müller, Martin; Davis, Graeme W; Schmitz, Dietmar; Sigrist, Stephan J

2011-12-16

319

Molecular recognition of upper rim functionalized cavitand and its unique dimeric capsule in the solid state.  

Science.gov (United States)

Cavitand possesses four 2,2'-bipyridyl pillars on its upper rim that encapsulates small guests, such as nitromethane, acetonitrile, methyl acetate, ethyl acetate, and N-methylacetamide, into a deep cavity to form host-guest complexes in a 1?:?1 ratio. Nitroethane, N,N-dimethylformamide, and N,N-dimethylacetamide were not bound in this manner. A guest-binding study and molecular mechanics calculations revealed that the four 2,2'-bipyridyl pillars of cavitand created a steric boundary that is responsible for selective guest recognition. In the solid state, cavitand formed a unique chiral capsule 2 by ?-? stacking interactions between the 2,2'-bipyridyl pillars. A nitromethane molecule was unusually placed deep inside the cavity, as directed by the multiple hydrogen bonding interactions between the nitromethane oxygen atoms, the C-H bonds of the bridge methylenes and the pillar phenyl groups. PMID:25470030

Kobayashi, Mutsumi; Takatsuka, Mei; Sekiya, Ryo; Haino, Takeharu

2014-12-01

320

Method for fusing bone  

Science.gov (United States)

Method for fusing bone. The present invention is a method for joining hard tissue which includes chemically removing the mineral matrix from a thin layer of the surfaces to be joined, placing the two bones together, and heating the joint using electromagnetic radiation. The goal of the method is not to produce a full-strength weld of, for example, a cortical bone of the tibia, but rather to produce a weld of sufficient strength to hold the bone halves in registration while either external fixative devices are applied to stabilize the bone segments, or normal healing processes restore full strength to the tibia.

Mourant, Judith R. (Los Alamos, NM); Anderson, Gerhard D. (Velarde, NM); Bigio, Irving J. (Los Alamos, NM); Johnson, Tamara M. (Los Alamos, NM)

1996-01-01

321

Cortical bone metastases  

International Nuclear Information System (INIS)

Twenty-five cases of bone metastases involving the cortex alone are reviewed. Seven patients had primary lung carcinoma, while 18 had primary tumors not previously reported to produce cortical bone metastases (tumors of the breast, kidney, pancreas, adenocarcinoma of unknown origin, multiple myeloma). Radiographically, these cortical lesions were well circumscribed, osteolytic, and produced soft-tissue swelling and occasional periosteal reaction. A recurrent pattern of metadiaphyseal involvement of the long bones of the lower extremity (particularly the femur) was noted, and is discussed. Findings reported in the literature, review, pathophysiology, and the role of skeletal radiographs, bone scans, and CT scans in evaluating cortical bone metastases are addressed

322

An upper mantle model for a western rim of the East European Craton  

Science.gov (United States)

The upper mantle structure is a subject of many seismological analysis but existent global models are often too general to depict regional variations. Our seismic model is a trial to construct a new reference model for the regional upper mantle structure in the western rim of the East European Craton. It is based on the P-wave traveltime analysis from seismograms recorded on Suwalki (SUW) seismic station belonging to the Polish Seismological Network. SUW station is situated in NE part of Poland on the East European Craton. The data from 249 natural seismic events were divided into four groups referring to the epicenters in the Western Mediterranean Sea region, Greece and Turkey region, Caucasus region and Mid-Atlantic Ridge region. Our analysis is based on the P-wave traveltimes observed up to 3000 km distance, which is sufficient to investigate upper mantle structure down to about 500 km. For each region, we established a single model which was fitted to all sections. 1D model was calculated for all regions except Jan Mayen region, for which we had to estimate 2D model because waves propagate through both oceanic and continental structure. However, the continental part of the Jan Mayen region model is similar to 1D model established for other regions. We also include data from TOR and SVEKALAPKO experiments to check the presence of the 300-km discontinuity. Our model of the upper mantle in the western rim of the East European Craton documents low velocity zone (LVZ), 300-km discontinuity and zone with the reduction of P-wave velocity above 410-km discontinuity. We attribute the existence of the 300-km discontinuity to the paleotectonic interaction between Laurentia, Baltica and Avalonia during the closure of the Tornquist Sea.

Dec, M.; Malinowski, M.; Nita, B.; Perchuc, E.

2012-04-01

323

RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Reverse Phase Protein Arrays (RPPA are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technologies, substantial amounts of analytical data are generated. Over 1000 samples may be printed on a single nitrocellulose slide. Up to 100 different proteins may be assessed using immunoperoxidase or immunoflorescence techniques in order to determine relative amounts of protein expression in the samples of interest. Results In this report an RPPA Information Management System (RIMS is described and made available with open source software. In order to implement the proposed system, we propose a metadata format known as reverse phase protein array markup language (RPPAML. RPPAML would enable researchers to describe, document and disseminate RPPA data. The complexity of the data structure needed to describe the results and the graphic tools necessary to visualize them require a software deployment distributed between a client and a server application. This was achieved without sacrificing interoperability between individual deployments through the use of an open source semantic database, S3DB. This data service backbone is available to multiple client side applications that can also access other server side deployments. The RIMS platform was designed to interoperate with other data analysis and data visualization tools such as Cytoscape. Conclusion The proposed RPPAML data format hopes to standardize RPPA data. Standardization of data would result in diverse client applications being able to operate on the same set of data. Additionally, having data in a standard format would enable data dissemination and data analysis.

Hennessy Bryan T

2008-12-01

324

Production optimization of thin-oil rims: Evaluation of a stochastic steepest-ascent approach  

Energy Technology Data Exchange (ETDEWEB)

This paper is concerned with water flood optimization of oil recovery from thin oil rims of gas-condensate fields. Such fields are notorious for gas and water coning problems, i.e. early gas or water breakthrough in producing wells, causing low recovery efficiency. The optimization method employed in this paper is of a steepest ascent type and may be seen as belonging to the class of stochastic optimization methods, as it involves estimation of the gradient search direction using ensembles of perturbed control strategies. The method is easy to implement and, moreover, it offers a great flexibility, as it is adjoint-free and is not restricted to the use of a specific reservoir simulator. The core of the method, named EnOpt, was recently proposed as an optimizer for the closed-loop reservoir production optimization, that is, the joint data assimilation and hydrocarbon production exercise. In this paper, the usefulness and performance of the optimization scheme are tested on a synthetic model of a homogeneous oil rim reservoir equipped with a horizontal producer and a horizontal injector placed on the opposite sides of the field. The reservoir geology is assumed known. The objective to optimize is a net present value (NPV) as a function, over a fixed production time-horizon, of the injected and produced fluid flow-rates weighted by corresponding economical factors and discount rates. Two different types of the control variables and corresponding constraints on their allowable values are considered. In both cases, the injection bottom-hole pressure is kept constant, and the freedom in controlling the fluid flow consisted in controlling the producer's bottom-hole pressure and the total liquid rate, respectively, at pre-specified time-instances. Simulation results confirm the potential of the optimization scheme. (author). 4 refs., 5 figs

Ibragimov, I. I.; Markovinovic, R.; Ermolaev, A. I.; Naevdal, G.

2008-11-15

325

Tumor primitivo neuroectodérmico de rim em criança Primitive neuroectodermal tumor of the kidney in children  

Directory of Open Access Journals (Sweden)

Full Text Available Objetivos: Caracterizar o tumor primitivo neuroectodérmico de rim como diagnóstico diferencial de tumor de Wilms e enfatizar a gravidade da doença. Métodos: Apresentamos um paciente com diagnóstico de tumor primitivo neuroectodérmico de rim, submetido a nefrectomia e ressecção completa do tumor, associadas a quimioterapia. Resultado: Inicialmente o paciente apresentou evolução favorável ao tratamento realizado, com poucas intercorrências, as quais eram relacionadas principalmente à agranulocitose decorrente da quimioterapia. Após dez meses do término da terapia o paciente apresentou recidiva tumoral em região cervical paramedular e abandonou o tratamento. Conclusão: O tumor primitivo neuroectodérmico de localização renal é muito raro e também muito grave. O papel do médico patologista é fundamental na caracterização da doença, pois utilizando de métodos histológicos e imunohistoquímicos, proporciona o diagnóstico definitivo.Objectives: To characterize primitive neuroectodermal tumor of the kidney as a differential diagnosis for Wilms tumor, and to emphasize the severity of the disease. Methods: We report the case of a patient with a diagnosis of primitive neuroectodermal tumor of the kidney who underwent nephrectomy and complete tumor resection combined with chemotherapy. Results: At the beginning, the patient had a favorable outcome, with few problems, especially related to the agranulocytosis. After ten months of the end of treatment the patient had a relapse at the paraspinal cervical region and abandoned the treatment. Conclusions: The primitive neuroectodermal tumor located in the kidney is very rare and also very aggressive. The role of the pathologist is fundamental for the characterization of the disease: using histological and immunohistochemical methods, he provides the final diagnosis.

Ana P. Kuczynski

2001-02-01

326

Tumor primitivo neuroectodérmico de rim em criança / Primitive neuroectodermal tumor of the kidney in children  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Objetivos: Caracterizar o tumor primitivo neuroectodérmico de rim como diagnóstico diferencial de tumor de Wilms e enfatizar a gravidade da doença. Métodos: Apresentamos um paciente com diagnóstico de tumor primitivo neuroectodérmico de rim, submetido a nefrectomia e ressecção completa do tumor, ass [...] ociadas a quimioterapia. Resultado: Inicialmente o paciente apresentou evolução favorável ao tratamento realizado, com poucas intercorrências, as quais eram relacionadas principalmente à agranulocitose decorrente da quimioterapia. Após dez meses do término da terapia o paciente apresentou recidiva tumoral em região cervical paramedular e abandonou o tratamento. Conclusão: O tumor primitivo neuroectodérmico de localização renal é muito raro e também muito grave. O papel do médico patologista é fundamental na caracterização da doença, pois utilizando de métodos histológicos e imunohistoquímicos, proporciona o diagnóstico definitivo. Abstract in english Objectives: To characterize primitive neuroectodermal tumor of the kidney as a differential diagnosis for Wilms tumor, and to emphasize the severity of the disease. Methods: We report the case of a patient with a diagnosis of primitive neuroectodermal tumor of the kidney who underwent nephrectomy an [...] d complete tumor resection combined with chemotherapy. Results: At the beginning, the patient had a favorable outcome, with few problems, especially related to the agranulocytosis. After ten months of the end of treatment the patient had a relapse at the paraspinal cervical region and abandoned the treatment. Conclusions: The primitive neuroectodermal tumor located in the kidney is very rare and also very aggressive. The role of the pathologist is fundamental for the characterization of the disease: using histological and immunohistochemical methods, he provides the final diagnosis.

Ana P., Kuczynski; Elizabeth S., Gugelmin; Rodrigo A.S., Netto.

2001-02-01

327

High bone density and bone health.  

Science.gov (United States)

The aim of this paper is to review the main aspects related to high bone density (HBD) as well as to discuss the physiologic mechanisms involved in bone health. There are still no well-defined criteria for identification of individuals with HBD and there are few studies on the topic. Most studies demonstrate that overweight, male gender, black ethnic background, physical activity, calcium and fluoride intake and use of medications such as statins and thiazide diuretics play a relevant and positive role on bone mineral density. Moreover, it is known that individuals with certain diseases such as obesity, diabetes, estrogen receptor-positive breast or endometrial cancer have greater bone density than healthy individuals, as well as athletes having higher bone density than non-athletes does not necessarily mean that they have healthy bones. A better understanding of risk and protective factors may help in the management of patients with bone frailty and have applicability in the treatment and in the prevention of osteoporosis, especially intervening on non-modifiable risk factors. PMID:22325788

Sarkis, Karin Sedó; Pinheiro, Marcelo de Medeiros; Szejnfeld, Vera Lúcia; Martini, Lígia Araújo

2012-03-01

328

Electromechanical effect in bone  

Energy Technology Data Exchange (ETDEWEB)

Although bone is piezoelectric, the signal from bent bone cannot be described by the piezoelectric effect if the samples are assumed to be homogeneous. To account for the symmetry properties and z-dependence of the signal from dry bone in cantilever bending, a theory postulating a polarization proportional to the gradient of the stress was proposed. The present work is concerned with a further examination of the applicability of the stress gradient theory to both dry and wet bone. Our measurements on dry bone samples cut from a bovine tibia indicate that the signal is not inversely proportional to the thickness squared, contrary to the prediction of the stress gradient theory for a homogeneous sample. Our measurements show that the moduli responsible for the signal in bent bone vary with position, a finding consistent with some earlier reports that the piezoelectric moduli determined in uniform stress measurements vary with position. These results imply that bone cannot be considered homogeneous. We then show that variations in the piezoelectric moduli can also account for the z-dependence and symmetry properties of the signal observed in bent bone. Since bone is not homogeneous, it is not necessary to introduce the phenomenological stress gradient theory to account for the otherwise anomalous electromechanical effect in bent bone, and we conclude that it is the variations in the piezoelectric moduli that produce the electromechanical effect in bent bone.

Johnson, Marvin Warren

1977-01-01

329

Thermal and fluid processes of a thin melt zone during femtosecond laser ablation of glass: the formation of rims by single laser pulses  

Energy Technology Data Exchange (ETDEWEB)

We study the formation mechanism of rims created around femtosecond laser ablated craters on glass. Experimental studies of the surface morphology reveal that a thin rim is formed around the smooth craters and is raised above the undamaged surface by about 50-100 nm. To investigate the mechanism of rim formation following a single ultrafast laser pulse, we perform a one-dimensional theoretical analysis of the thermal and fluid processes involved in the ablation process. The results indicate the existence of a very thin melted zone below the surface and suggest that the rim is formed by the high pressure plasma producing a pressure-driven fluid motion of the molten material outwards from the centre of the crater. The numerical solutions of pressure-driven fluid motion of the thin melt demonstrate that the melt can flow to the crater edge and form a rim within the first nanoseconds of the ablation process. The possibility that a tall rim can be formed during the initial stages of the plasma is suggestive that the rim may tilt outwards towards the low pressure region creating a resolidified melt splash as observed in the experiments. The possibility of controlling or suppressing the rim formation is discussed also.

Ben-Yakar, Adela [Mechanical Engineering Department, University of Texas at Austin, Austin, TX 78712 (United States); Harkin, Anthony [School of Mathematical Sciences, Rochester Institute of Technology, Rochester, NY 14623 (United States); Ashmore, Jacqueline [Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138 (United States); Byer, Robert L [Applied Physics Department, Ginzton Lab, Stanford University, CA 94305 (United States); Stone, Howard A [Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138 (United States)

2007-03-07

330

Thermal and fluid processes of a thin melt zone during femtosecond laser ablation of glass: the formation of rims by single laser pulses  

International Nuclear Information System (INIS)

We study the formation mechanism of rims created around femtosecond laser ablated craters on glass. Experimental studies of the surface morphology reveal that a thin rim is formed around the smooth craters and is raised above the undamaged surface by about 50-100 nm. To investigate the mechanism of rim formation following a single ultrafast laser pulse, we perform a one-dimensional theoretical analysis of the thermal and fluid processes involved in the ablation process. The results indicate the existence of a very thin melted zone below the surface and suggest that the rim is formed by the high pressure plasma producing a pressure-driven fluid motion of the molten material outwards from the centre of the crater. The numerical solutions of pressure-driven fluid motion of the thin melt demonstrate that the melt can flow to the crater edge and form a rim within the first nanoseconds of the ablation process. The possibility that a tall rim can be formed during the initial stages of the plasma is suggestive that the rim may tilt outwards towards the low pressure region creating a resolidified melt splash as observed in the experiments. The possibility of controlling or suppressing the rim formation is discussed also

331

16 CFR Table 3 to Part 1512 - Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test...  

Science.gov (United States)

...Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test Procedure 3 Table 3 to Part 1512 Commercial...Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test Procedure Observation angle (degrees)...

2010-01-01

332

Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225  

Science.gov (United States)

A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage. PMID:20651937

Chen, Xiaoyuan; Ji, Min; Fisher, Darrell R.

2010-01-01

333

An oxygen isotope study of Wark-Lovering rims on type A CAIs in primitive carbonaceous chondrites  

Science.gov (United States)

Calcium-aluminium-rich Inclusions (CAIs) and the thin Wark-Lovering (WL) rims of minerals surrounding them offer a record of the nature of changing conditions during the earliest stages of Solar System formation. Considerable heterogeneity in the gas composition in the immediate vicinity of the proto-Sun had previously been inferred from oxygen isotopic variations in the WL rim of a CAI from Allende (Simon et al., 2011). However, high precision and high spatial resolution oxygen isotope measurements presented in this study show that WL rim and pristine core minerals of individual CAIs from meteorites that had experienced only low degrees of alteration or low grade metamorphism (one from Léoville (reduced CV3), two in QUE 99177 (CR3.0) and two in ALHA 77307 (CO3.0)) are uniformly 16O-rich. This indicates that the previously observed variations are the result of secondary processes, most likely on the asteroid parent body, and that there were no temporal or spatial variations in oxygen isotopic composition during CAI and WL rim formation. Such homogeneity across three groups of carbonaceous chondrites lends further support for a common origin for the CAIs in all chondrites. 16O-poor oxygen reservoirs such as those associated with chondrule formation, were probably generated by UV photo-dissociation involving self-shielding mechanisms and must have occurred elsewhere in outer regions of the solar accretion disk.

Bodénan, Jean-David; Starkey, Natalie A.; Russell, Sara S.; Wright, Ian P.; Franchi, Ian A.

2014-09-01

334

75 FR 52969 - Rim of the Valley Corridor Special Resource Study, Los Angeles and Ventura Counties, CA; Notice...  

Science.gov (United States)

...Corridor Special Resource Study. At this time, it has...participate throughout the study process. Additionally...following its release. For initial scoping and alternatives...information germane to this study. All responses to this...The public scoping period for the Rim of the...

2010-08-30

335

Heterogenous Oxygen Isotopic Composition of a Complex Wark-Lovering Rim and the Margin of a Refractory Inclusion from Leoville  

Science.gov (United States)

Wark-Lovering (WL) rims [1] surrounding many refractory inclusions represent marker events in the early evolution of the Solar System in which many inclusions were exposed to changes in pressure [2], temperature [3], and isotopic reservoirs [4-7]. The effects of these events can be complex, not only producing mineralogical variability of WL rims [2], but also leading to mineralogical [8-10] and isotopic [7, 11, 12] changes within inclusion interiors. Extreme oxygen isotopic heterogeneity measured in CAIs has been explained by mixing between distinct oxygen gas reservoirs in the nebula [13]. Some WL rims contain relatively simple mineral layering and/or are isotopically homogeneous [14, 15]. As part of a larger effort to document and understand the modifications observed in some CAIs, an inclusion (L6) with a complex WL rim from Leoville, a member of the reduced CV3 subgroup was studied. Initial study of the textures and mineral chemistry was presented by [16]. Here we present NanoSIMS oxygen isotopic measurements to complement these petrologic observations.

Simon, J. I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.

2014-01-01

336

Garnet reaction rims from the breakdown of Staurolite in polymetamorphic micashists from the Rappold complex, Austroalpine basement, Eastern Alps  

Science.gov (United States)

In polymetamorphic pelites of the Rappold complex in the Wölz crystalline basement (Eastern Alps) reaction rim garnets at staurolite-quartz interfaces (type I) and single grain garnets along previous staurolite-white mica interfaces (type II) were formed. The garnet reaction rims were formed during the Cretaceous amphibolite facies metamorphic overprint of the pre-existing mineral assemblages comprising garnet, staurolite, and kyanite from an amphibolite facies metamorphic event probably of Variscian age. The newly formed garnet may take the form of reaction rims along the margins of large pre-existing staurolite blasts. The initial growth increments of garnet have low grossular content, and reaction rim growth was controlled by the transfer of Fe, Mg and Mn components from the staurolite-garnet interface to the quartz-garnet interface. Later garnet growth increments have relatively high grossular content due to consumption of matrix plagioclase, which was destabilized by successive pressure increase. The grossular content of newly formed garnet shows systematic increase towards sites where plagioclase breaks down indicating that transport of calcium through the matrix was sluggish. On the basis of reaction microstructures it is demonstrated that the mineral assemblage garnet + kyanite + biotite + paragonite was formed at the conditions of eo-alpine amphibolite facies overprint while staurolite and plagioclase broke down successively with increasing pressure.

Prenzel, Jannis Dominik; Abart, Rainer

2009-12-01

337

Monostotic Paget Disease of Bone or Bone Metastasis?  

Directory of Open Access Journals (Sweden)

Full Text Available Paget’s disease of bone is a metabolic bone disorder with male predominance and characterized by increased bone turnover. Recent literature indicates a reduction in incidence and severity. We report a 55 years old female patient who was admitted with knee pain, and whose pelvis x-ray demonstrated pathological features. She was investigated with preliminary diagnoses of Paget’s disease of bone, osteosclerotic bone metastasis and primary bone tumor. Histopathological examination of bone biopsy confirmed Paget’s disease of bone and Paget’s disease of bone is reviewed. Turk J Phys Med Rehab 2008;54:73-6

Özlem Erdem Süer

2008-06-01

338

Spinal fusions: bone and bone substitutes  

OpenAIRE

Vertebral arthrodesis is one of the most commonly performed, yet incompletely understood, procedures in spinal surgery. Despite major progress in internal fixation techniques, the high rate of non-unions indicates that physiologic, biologic and molecular events that are crucial to this process are not well known. This article will analyze the general biology of bone regeneration, and particularly discuss the properties and use of various bone graft materials and graft substitutes.

Marchesi, D. G.

2000-01-01

339

Correlation between 3D microstructural and 2D histomorphometric properties of subchondral bone with healthy and degenerative cartilage of the knee joint.  

Science.gov (United States)

Cartilage degeneration of the knee joint is considered to be a largely mechanically driven process. We conducted a microstructural and histomorphometric analysis of subchondral bone samples of intact cartilage and in samples with early and higher- grade arthritic degeneration to compare the different states and correlate the findings with the condition of hyaline cartilage. These findings will enable us to evaluate changes in biomechanical properties of subchondral bone during the evolution of arthritic degeneration, for which bone density alone is an insufficient parameter. From a continuous series of 80 patients undergoing implantation of total knee endoprosthesis 30 osteochondral samples with lesions macroscopically classified as ICRS grade 1b (group A) and 30 samples with ICRS grade 3a or 3b lesions (group B) were taken. The bone samples were assessed by 2D histomorphometry (semiautomatic image analysis system) and 3D microstructural analysis (high-resolution micro-CT system). The cartilage was examined using the semiquantitative real-time PCR gene expression of collagen type I and II and aggrecan. Both histomorphometry and microstructural and biomechanical analysis of subchondral bone in groups A and B consistently revealed progressive changes of both bone and cartilage compared with healthy controls. The severity of cartilage degeneration as assessed by RT PCR was significantly correlated with BV/TV (Bone Volume Fraction), Tb.Th (Trabecular Thickness) showed a slight increase. Tb.N (Trabecular Number), Tb.Sp (Trabecular separation) SMI (Structure Model Index), Conn.D (Connectivity Density) and DA (Degree of Anisotropy) were inversely correlated. We saw sclerotic transformation and phagocytic reticulum cells. Bone volume fraction decreased with an increasing distance from the cartilage with the differences compared with healthy controls becoming greater in more advanced cartilage damage. The density of subchondral bone alone is considered an unreliable parameter for classifying changes evolving over time. The progressive damage of subchondral bone seen in the present study correlates well with cartilage changes. Trabecular orientation is also impaired, which explains the changes in biomechanical parameters and the inadequate load transfer and excessive loading of cartilage. Besides subchondral bone density, which in turn correlates with cartilage thickness, other parameters such as structure model index and grade of anisotropy best reflect mechanical properties such as Young modulus, compressive strength, tensile stress, and failure energy. However, it remains unclear whether the mechanical interaction of the mineralized subchondral tissues with articular cartilage works vice versa. The possibility of a biochemical signalling from the degenerating cartilage via the synovial fluid and bone- cartilage crosstalks via subchondral pores may indeed explain a certain depth-dependency of subchondral bone changes. PMID:24828695

Lahm, Andreas; Kasch, Richard; Spank, Heiko; Erggelet, Christoph; Esser, Jan; Merk, Harry; Mrosek, Eike

2014-11-01

340

Biomaterials and bone mechanotransduction  

Science.gov (United States)

Bone is an extremely complex tissue that provides many essential functions in the body. Bone tissue engineering holds great promise in providing strategies that will result in complete regeneration of bone and restoration of its function. Currently, such strategies include the transplantation of highly porous scaffolds seeded with cells. Prior to transplantation the seeded cells are cultured in vitro in order for the cells to proliferate, differentiate and generate extracellular matrix. Factors that can affect cellular function include the cell-biomaterial interaction, as well as the biochemical and the mechanical environment. To optimize culture conditions, good understanding of these parameters is necessary. The new developments in bone biology, bone cell mechanotransduction, and cell-surface interactions are reviewed here to demonstrate that bone mechanotransduction is strongly influenced by the biomaterial properties.

Sikavitsas, V. I.; Temenoff, J. S.; Mikos, A. G.; McIntire, L. V. (Principal Investigator)

2001-01-01

341

Bone tumors: Nursing care  

International Nuclear Information System (INIS)

Bone tumors represent approximately 5% of childhood malignancies. osteosarcoma is the primary malignant bone tumor, accounting for 60% of cancer with peak incidence in the 2nd decade of life. Ewing's sarcoma is the second most common bone cancer with peak at a slightly younger age. This presentation discusses similarities and differences in the diagnosis and treatment of these two malignancies. Diagnostic procedures include plain radiographs, CT and MRI of the primary site, plain x-ray and CT of the chest, bone scan, and biopsy of the primary tumor. For patients diagnosed with Ewing's sarcoma, a bone marrow aspirate and biopsy will also be required. Our current approach to the treatment of bone tumors includes preoperative combination chemotherapy and en bloc surgical removal of the tumor followed by postoperative chemotherapy. In the case of Ewing's sarcoma, radiation therapy may be employed in addition to surgery, if margins are questionable of instead of surgery, if the tumor is not resectable

342

Bone Biology for Kids  

Science.gov (United States)

Bone Biology for Kids was created by University of Washington professor Dr. Susan Ott as an educational website for 4th - 8th grade students and as a resource for science and biology teachers. The main sections of the site include All About Bones, Bone Diseases, and How to Build Your Bone Strength. The site also offers an interactive Index & Definitions section, a Bone-quiz Yahtzee game, and a question / answer page. The TeacherâÂÂs Corner section currently contains two supplementary worksheets, and may offer more educational resources in the future. Some of the siteâÂÂs sections are still in progress, but overall the website contains great images and a good amount of information to explore. The site also links to high school and college curriculum from the American Society for Bone and Mineral Research.

343

Bone X-Ray (Radiography)  

Medline Plus

Full Text Available X-ray (Radiography) - Bone Play Video Clip (00:04:40) Your Radiologist Explains Bone X-ray What is Bone X-ray ( ... of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive ...

344

Bone X-Ray (Radiography)  

Medline Plus

Full Text Available X-ray (Radiography) - Bone Play Video Clip (00:04:40) Your Radiologist Explains Bone X-ray What is Bone X-ray (Radiography)? What ... limitations of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is ...

345

Nanocomposites and bone regeneration  

Science.gov (United States)

This manuscript focuses on bone repair/regeneration using tissue engineering strategies, and highlights nanobiotechnology developments leading to novel nanocomposite systems. About 6.5 million fractures occur annually in USA, and about 550,000 of these individual cases required the application of a bone graft. Autogenous and allogenous bone have been most widely used for bone graft based therapies; however, there are significant problems such as donor shortage and risk of infection. Alternatives using synthetic and natural biomaterials have been developed, and some are commercially available for clinical applications requiring bone grafts. However, it remains a great challenge to design an ideal synthetic graft that very closely mimics the bone tissue structurally, and can modulate the desired function in osteoblast and progenitor cell populations. Nanobiomaterials, specifically nanocomposites composed of hydroxyapatite (HA) and/or collagen are extremely promising graft substitutes. The biocomposites can be fabricated to mimic the material composition of native bone tissue, and additionally, when using nano-HA (reduced grain size), one mimics the structural arrangement of native bone. A good understanding of bone biology and structure is critical to development of bone mimicking graft substitutes. HA and collagen exhibit excellent osteoconductive properties which can further modulate the regenerative/healing process following fracture injury. Combining with other polymeric biomaterials will reinforce the mechanical properties thus making the novel nano-HA based composites comparable to human bone. We report on recent studies using nanocomposites that have been fabricated as particles and nanofibers for regeneration of segmental bone defects. The research in nanocomposites, highlight a pivotal role in the future development of an ideal orthopaedic implant device, however further significant advancements are necessary to achieve clinical use.

James, Roshan; Deng, Meng; Laurencin, Cato T.; Kumbar, Sangamesh G.

2011-12-01

346

Bone Healing: Little Secrets  

OpenAIRE

The ability to stimulate bone repair, heal non-unions, or restore lost segments of bone is a common goal among orthopaedic surgeons, trauma surgeons, and scientists who investigate wound healing responses. The stimulation of bone repair has been reported using biophysical means such as electromagnetic fields, low-intensity pulsed ultrasound and extracorporeal shockwave therapy. Reported studies on the use of these modalities suggest beneficial effects but the quality of the evidence and high ...

Einhorn, T. A.

2010-01-01

347

Hypercalciuric Bone Disease  

Science.gov (United States)

Hypercalciuria plays an important causal role in many patients with calcium oxalate (CaOx) stones. The source of the hypercalciuria includes increased intestinal Ca absorption and decreased renal tubule Ca reabsorption. In CaOx stone formers with idiopathic hypercalciuria (IH), Ca metabolic balance studies have revealed negative Ca balance and persistent hypercalciuria in the fasting state and during low dietary Ca intake. Bone resorption may also contribute to the high urine Ca excretion and increase the risk of bone loss. Indeed, low bone mass by DEXA scanning has been discovered in many IH patients. Thiazide diuretic agents reduce urine Ca excretion and may increase bone mineral density (BMD), thereby reducing fracture risk. Dietary Ca restriction that has been used unsuccessfully in the treatment of CaOx nephrolithiasis in the past may enhance negative Ca balance and accelerate bone loss. DEXA scans may demonstrate low BMD at the spine, hip, or forearm, with no predictable pattern. The unique pattern of bone histologic changes in IH differs from other causes of low DEXA bone density including postmenopausal osteoporosis, male hypogonadal osteoporosis, and glucocorticoid-induced osteoporosis. Hypercalciuria appears to play an important pathologic role in the development of low bone mass, and therefore correction of urine Ca losses should be a primary target for treatment of the bone disease accompanying IH.

Favus, Murray J.

2008-09-01

348

Metastatic bone disease  

Directory of Open Access Journals (Sweden)

Full Text Available Metastatic bone disease is the most common malignancy of bone, it is estimated that 70% of all malignant bone tumors are metastatic in origin. At autopsy it has been reported between 30 to 85% of patients who die from cancer show occult skeletal metastases. Bone is the third most common site of metastatic process after lung and liver. 80% of metastatic bone disease arise from Ca of breast, prostate, lung, kidney and thyroid. Typical location are thoracolumbal spine, pelvis, ribs, skull and proximal of femur and humerus. Pathogenesis of metastatic bone disease had been explained by Paget’s “Seed and Soil” theory and Ewing’s circulatory theory. Diagnostic procedures include complete laboratory examination, diagnostic bone imaging, chest x-ray, total body scan, CT-scan of chest, abdomen and pelvis and confirmed by histopathological examination. Management of metastatic bone disease is palliative that includes : chemotherapy, radiotherapy, bisphosphonates and surgical treatment for impending / established pathologic fracture to alleviate pain, ease nursing and restore functional activity. (Med J Indones 2004; 13: 127-31 Keywords: bone cancer, metastases

Errol U. Hutagalung

2004-05-01

349

Bone marrow fat.  

Science.gov (United States)

Bone marrow fat (BMF) results from an accumulation of fat cells within the bone marrow. Fat is not a simple filling tissue but is now considered as an actor within bone microenvironment. BMF is not comparable to other fat depots, as in subcutaneous or visceral tissues. Recent studies on bone marrow adipocytes have shown that they do not appear only as storage cells, but also as cells secreting adipokines, like leptin and adiponectin. Moreover bone marrow adipocytes share the same precursor with osteoblasts, the mesenchymal stem cell. It is now well established that high BMF is associated with weak bone mass in osteoporosis, especially during aging and anorexia nervosa. But numerous questions remain discussed: what is the precise phenotype of bone marrow adipocytes? What is the real function of BMF, and how does bone marrow adipocyte act on its environment? Is the increase of BMF during osteoporosis responsible for bone loss? Is BMF involved in other diseases? How to measure BMF in humans? A better understanding of BMF could allow to obtain new diagnostic tools for osteoporosis management, and could open major therapeutic perspectives. PMID:24703396

Hardouin, Pierre; Pansini, Vittorio; Cortet, Bernard

2014-07-01

350

Toxicokinetics of bone lead.  

OpenAIRE

This article discusses bone as a source of lead to the rest of the body and as a record of past lead exposure. Bone lead levels generally increase with age at rates dependent on the skeletal site and lead exposure. After occupational exposure, the slow decline in blood lead, a 5- to 19-year half-life, reflects the long skeletal half-life. Repeated measurements of bone lead demonstrate the slow elimination of lead from bone. Stable isotope ratios have revealed many details of skeletal uptake a...

Rabinowitz, M. B.

1991-01-01

351

Bone marrow transplant - discharge  

Science.gov (United States)

Transplant - bone marrow - discharge; Stem cell transplant - discharge; Hematopoietic stem cell transplant - discharge; Reduced intensity, non-myeloablative transplant - discharge; Mini transplant - discharge; Allogenic ...

352

Multiple soft tissue aneurysmal cysts: An occurrence after resection of primary aneurysmal bone cyst of fibula  

Directory of Open Access Journals (Sweden)

Full Text Available We report a case of multiple extraosseous aneurysmal cysts occurring in the muscle and subcutaneous plane of postero-lateral aspects of the upper right leg. They appeared about 15 months after resection of aneurysmal bone cyst of the upper end of the fibula. They varied in size from 2 cm to 5 cm. Radiologically they were well-defined lesions with central septate areas surrounded by a rim of calcification. Histologically they showed central cystic spaces separated by septa consisting of fibroblasts, osteoclast type of giant cells and reactive woven bone. Thus they showed histological similarity with aneurysmal bone cysts, but did not show any connection with the bone. Only very few examples of aneurysmal cysts of soft tissue had been described in the past one decade and they were reported in various locations including rare sites such as arterial wall and larynx. Recent cytogenetic analyses have shown abnormalities involving 17p11-13 and/or 16q22 in both osseous and extraosseous aneurysmal cysts indicating its probable neoplastic nature. Our case had unique features like multiplicity and occurrence after resection of primary aneurysmal bone cyst of the underlying bone.

Karkuzhali P

2007-01-01

353

Binaural cochlear implantation after bilateral temporal bone fractures.  

Science.gov (United States)

In this clinical note we discuss the indications, feasibility, and outcomes of binaural simultaneous cochlear implantation (CI) following bilateral transverse temporal bone (TB) fractures. A 41-year-old male, totally deaf after a bilateral TB fracture, underwent an audiological, electrophysiological, and imaging investigation in order to assess the integrity of the VIIIth cranial nerves. Five months later he received a simultaneous bilateral CI. Speech perception tests were conducted at different time points. A significant advantage by dichotic listening was observed since the beginning of the habilitation program. The patient achieved a 100% word and sentences recognition in quiet at 12 months. His listening skills in noisy conditions were improved by the use of two implants. A CI in TB fractures is feasible if the VIII nerve is intact and the cochlea is spared by the fracture rim. The early timing of the procedure probably contributed to its success by preventing cochlear fibrosis and ossification. PMID:20608881

Zanetti, Diego; Campovecchi, Chiara Barbara; Pasini, Sara

2010-10-01

354

Clinical data integration of distributed data sources using Health Level Seven (HL7 v3-RIM mapping  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Health information exchange and health information integration has become one of the top priorities for healthcare systems across institutions and hospitals. Most organizations and establishments implement health information exchange and integration in order to support meaningful information retrieval among their disparate healthcare systems. The challenges that prevent efficient health information integration for heterogeneous data sources are the lack of a common standard to support mapping across distributed data sources and the numerous and diverse healthcare domains. Health Level Seven (HL7 is a standards development organization which creates standards, but is itself not the standard. They create the Reference Information Model. RIM is developed by HL7's technical committees. It is a standardized abstract representation of HL7 data across all the domains of health care. In this article, we aim to present a design and a prototype implementation of HL7 v3-RIM mapping for information integration of distributed clinical data sources. The implementation enables the user to retrieve and search information that has been integrated using HL7 v3-RIM technology from disparate health care systems. Method and results We designed and developed a prototype implementation of HL7 v3-RIM mapping function to integrate distributed clinical data sources using R-MIM classes from HL7 v3-RIM as a global view along with a collaborative centralized web-based mapping tool to tackle the evolution of both global and local schemas. Our prototype was implemented and integrated with a Clinical Database management Systems CDMS as a plug-in module. We tested the prototype system with some use case scenarios for distributed clinical data sources across several legacy CDMS. The results have been effective in improving information delivery, completing tasks that would have been otherwise difficult to accomplish, and reducing the time required to finish tasks which are used in collaborative information retrieval and sharing with other systems. Conclusions We created a prototype implementation of HL7 v3-RIM mapping for information integration between distributed clinical data sources to promote collaborative healthcare and translational research. The prototype has effectively and efficiently ensured the accuracy of the information and knowledge extractions for systems that have been integrated

Viangteeravat Teeradache

2011-11-01

355

Distinct focal lesions of the femoral head: imaging features suggesting an atypical and minimal form of bone necrosis  

Energy Technology Data Exchange (ETDEWEB)

Heading AbstractObjective. To document the imaging findings observed in patients with an unusual pattern of abnormality of the femoral head, most likely representing osteonecrosis.Design and patients. The imaging findings in 11 patients (10 men, 1 woman; age range 32-55 years) with a distinct lesion of the femoral head were reviewed with particular attention to the morphologic appearance, location, and extent of the lesion(s) in the proximal femur.Results. The 16 lesions identified in these patients extended to the subchondral area. Articular collapse was not evident in any hip. Radiography and CT showed areas of mixed bone sclerosis and osteolysis surrounded by sclerotic margins. On MR imaging, the signal intensity characteristics of the osseous lesion(s) were most commonly similar to those of fluid. Histopathologic findings, available in two hips, were typical of osteonecrosis. There was evidence of correlation of the site of the lesion with the known general distribution and anastomoses of arteries supplying the femoral head.Conclusion. A distinct, focal lesion of the femoral head is believed to represent an atypical form of bone necrosis. Its restriction to a small portion of the femoral head may relate to localized vascular anatomy. Recognition of the quite characteristic imaging findings can prevent misdiagnosis and may have implications for the prediction of the natural course of the disease. (orig.)

Theodorou, Daphne J. [Department of Radiology, School of Medicine, University of California, San Diego Medical Center, San Diego, California (United States); Department of Radiology, Veterans Administration Medical Center, San Diego, California (United States); Department of Radiology, Veterans Administration Medical Center, 3350 La Jolla Village Drive, San Diego, California 92161 (United States); Theodorou, Stavroula J.; Resnick, Donald [Department of Radiology, School of Medicine, University of California, San Diego Medical Center, San Diego, California (United States); Department of Radiology, Veterans Administration Medical Center, San Diego, California (United States); Haghighi, Parviz [Department of Pathology, Veterans Administration Medical Center, San Diego, California (United States)

2002-08-01

356

Distinct focal lesions of the femoral head: imaging features suggesting an atypical and minimal form of bone necrosis  

International Nuclear Information System (INIS)

Heading AbstractObjective. To document the imaging findings observed in patients with an unusual pattern of abnormality of the femoral head, most likely representing osteonecrosis.Design and patients. The imaging findings in 11 patients (10 men, 1 woman; age range 32-55 years) with a distinct lesion of the femoral head were reviewed with particular attention to the morphologic appearance, location, and extent of the lesion(s) in the proximal femur.Results. The 16 lesions identified in these patients extended to the subchondral area. Articular collapse was not evident in any hip. Radiography and CT showed areas of mixed bone sclerosis and osteolysis surrounded by sclerotic margins. On MR imaging, the signal intensity characteristics of the osseous lesion(s) were most commonly similar to those of fluid. Histopathologic findings, available in two hips, were typical of osteonecrosis. There was evidence of correlation of the site of the lesion with the known general distribution and anastomoses of arteries supplying the femoral head.Conclusion. A distinct, focal lesion of the femoral head is believed to represent an atypical form of bone necrosis. Its restriction to a small portion of the femoral head may relate to localized vascular anatomy. Recognition of the quite characteristic imaging findings can prevent misdiagnosis and may have implications for the prediction of the natural course of the disease. (orig.)

357

Bone X-Ray (Radiography)  

Medline Plus

Full Text Available ... diagnosis of bone cancer . locate foreign objects in soft tissues around or in bones. top of page ... Dense bone absorbs much of the radiation while soft tissue, such as muscle, fat and organs, allow ...

358

Bone X-Ray (Radiography)  

Medline Plus

Full Text Available ... or in bones. top of page How should I prepare? Most bone x-rays require no special ... to 10 minutes. top of page What will I experience during and after the procedure? A bone ...

359

Aspiration and Biopsy: Bone Marrow  

Science.gov (United States)

... Doctors & Hospitals > Medical Tests & Exams > Aspiration and Biopsy: Bone Marrow Print A A A Text Size What's in ... Child If You Have Questions What It Is Bone marrow aspirations and biopsies are performed to examine bone ...

360

Breast Cancer and Bone Loss  

Science.gov (United States)

... Breast Cancer and Bone Loss Share: Fact Sheet Breast Cancer and Bone Loss July, 2010 Download PDFs English ... JoAnn Pinkerton, MD What is the link between breast cancer and bone loss? Certain treatments for breast cancer ...

361

Low Bone Mass in Thalassemia  

Science.gov (United States)

Why is low bone mass an issue in thalassemia? Having bones that grow and develop into strong, ... the individual engages in regularly. However, people with thalassemia are also more prone to develop bone mass ...

362

Ascaridíase das vias urinárias: um caso de penetração de Ascaris lumbricoides através do rim  

Directory of Open Access Journals (Sweden)

Full Text Available Uma criança de 2 anos com desnutrição grave e infestação intestinal maciça por Ascaris lumbricoides, apresentou como complicação, documentada em necrópsia, a migração de vermes adultos para a cavidade peritonial e penetração aberrante de dois parasitos através do rim esquerdo. Os Ascaris ficaram alojados no sistema pielo-ureteral, determinando grave infecção purulenta e obstrução ureteral. Esta complicação demonstra a capacidade agressiva de vermes erráticos na cavidade peritonial, com possibilidade de perfurar mesmo uma víscera sólida. São comentados os fatores que facilitaram a migração dos vermes por aqueles órgãos.The author reports an autopsy case of a two year old child with massive intestinal ascariasis and malnutrition, presenting the migration of two adult Ascaris lumbricoides through the left kidney into the pyelo-ureteral system. As a result she developed acute pyelonephritis and ureteral obstruction. Previously the worms left the intestine into the peritoneal cavity (lesser sac through a duodenal cleft. Factors contributing to the migration of the roundworms by those pathways are discussed.

Mario Caymmi Gomes

1977-10-01

363

Ascaridíase das vias urinárias: um caso de penetração de Ascaris lumbricoides através do rim  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Uma criança de 2 anos com desnutrição grave e infestação intestinal maciça por Ascaris lumbricoides, apresentou como complicação, documentada em necrópsia, a migração de vermes adultos para a cavidade peritonial e penetração aberrante de dois parasitos através do rim esquerdo. Os Ascaris ficaram alo [...] jados no sistema pielo-ureteral, determinando grave infecção purulenta e obstrução ureteral. Esta complicação demonstra a capacidade agressiva de vermes erráticos na cavidade peritonial, com possibilidade de perfurar mesmo uma víscera sólida. São comentados os fatores que facilitaram a migração dos vermes por aqueles órgãos. Abstract in english The author reports an autopsy case of a two year old child with massive intestinal ascariasis and malnutrition, presenting the migration of two adult Ascaris lumbricoides through the left kidney into the pyelo-ureteral system. As a result she developed acute pyelonephritis and ureteral obstruction. [...] Previously the worms left the intestine into the peritoneal cavity (lesser sac) through a duodenal cleft. Factors contributing to the migration of the roundworms by those pathways are discussed.

Mario Caymmi, Gomes.

1977-10-01

364

AN INVESTIGATION ON THE MORPHOLOGICAL EVOLUTION OF BRIGHT-RIMMED CLOUDS  

International Nuclear Information System (INIS)

A new radiative driven implosion (RDI) model based on smoothed particle hydrodynamics technique is developed and applied to investigate the morphological evolutions of molecular clouds under the effect of ionizing radiation. This model self-consistently includes the self-gravity of the cloud in the hydrodynamical evolution, the UV radiation component in the radiation transferring equations, the relevant heating and cooling mechanisms in the energy evolution, and a comprehensive chemical network. The simulation results reveal that under the effect of ionizing radiation, a molecular cloud may evolve through different evolutionary sequences. Depending on its initial gravitational state, the evolution of a molecular cloud does not necessarily follow a complete morphological evolution sequence from type A?B?C, as described by previous RDI models. When confronted with observations, the simulation results provide satisfactory physical explanations for a series of puzzles derived from bright-rimmed clouds observations. The consistency of the modeling results with observations shows that the self-gravity of a molecular cloud should not be neglected in any investigation on the dynamical evolution of molecular clouds when they are exposed to ionizing radiation.

365

The Chandra View of the Triggered Star Formation in Bright Rimmed Clouds  

Science.gov (United States)

The formation of mamy stars in the Galaxy appears to be triggered by some external compression processes such as OB ionization, winds or supernovae shocks. However, quantitative understanding of triggering processes is still primitive. The radiation driven implosion (RDI) is currently considered as the most observationally testable model using bright rimmed clouds (BRCs) on the edges of large HII regions. We have made several short observations with the Chandra X-ray Observatory to elucidate the mechanism, efficiency and stellar populations produced by small-scale triggered star formation around HII regions. X-ray selection is effective in tracing triggered low mass stars from protostellar through disk-free stages, both embedded in the cloud and in the unobscured cloud vicinity. The results of these studies are presented and generally support the RDI model. Triggering by HII region shocks is not restricted to a single episode, but can continue for millions of years. We discuss plans for the collection of BRC young star samples at different morphological stages of the triggering and cloud ablation process to test RDI predictions and to quantify the role of RDI in Galactic star formation.

Feigelson, Eric; Getman, K.

2009-01-01

366

An Investigation on the Morphological Evolution of Bright-Rimmed Clouds  

Science.gov (United States)

A new radiative driven implosion (RDI) model based on smoothed particle hydrodynamics technique is developed and applied to investigate the morphological evolutions of molecular clouds under the effect of ionizing radiation. This model self-consistently includes the self-gravity of the cloud in the hydrodynamical evolution, the UV radiation component in the radiation transferring equations, the relevant heating and cooling mechanisms in the energy evolution, and a comprehensive chemical network. The simulation results reveal that under the effect of ionizing radiation, a molecular cloud may evolve through different evolutionary sequences. Depending on its initial gravitational state, the evolution of a molecular cloud does not necessarily follow a complete morphological evolution sequence from type A?B?C, as described by previous RDI models. When confronted with observations, the simulation results provide satisfactory physical explanations for a series of puzzles derived from bright-rimmed clouds observations. The consistency of the modeling results with observations shows that the self-gravity of a molecular cloud should not be neglected in any investigation on the dynamical evolution of molecular clouds when they are exposed to ionizing radiation.

Miao, Jingqi; White, Glenn J.; Thompson, M. A.; Nelson, Richard P.

2009-02-01

367

Building for the Pacific Rim Countries. Energy-efficient building strategies for hot, humid climates  

Energy Technology Data Exchange (ETDEWEB)

This book has been published by the Solar Energy Industries Association (SEIA), the US trade association of the solar thermal, photovoltaic, and passive solar manufacturers, distributors, and component suppliers. Its purpose is to help architects, builders, and developers construct energy-efficient homes in hot humid climates like the Pacific Rim Countries, and to allow occupants of these homes to enjoy enhanced comfort without reliance on mechanical air-conditioning systems. Two important factors are addressed in this book. First, the past few years have seen a tremendous increase in practical applications of new research. The current popularity of ceiling paddle fans, attic radiant barriers and natural daylighting attest to the importance of keeping up with the latest concepts in energy-reduction and comfort-awareness. Professionals who have been in the field for the past few years may be unaware of the latest research findings--some of which dramatically alter prior thinking on such subjects as natural ventilation or mechanical air conditioning. The second factor is the importance of site-specific characteristics, which greatly affect building strategies and designs. A thorough understanding of the climate is a prerequisite to good building design. Such factors as temperature, humidity, wind speed and direction, and solar radiation must be understood and properly integrated into the design for the home to be truly energy-efficient.

Sheinkopf, K. [ed.

1991-09-01

368

Electromagnetic evidence for an ancient avelanche caldera rim onthe south flank of mount merapi, indonesia  

Energy Technology Data Exchange (ETDEWEB)

Long-Offset Transient Electromagnetic (LOTEM) data andVIBROTEM data from the south flank of Mount Merapi on Java island,Indonesia, are interpreted with one-dimensional (1D) inversions as wellas two-dimensional (2D) forward modelling. One-dimensional jointinversions of several components of the electromagnetic field withOccam's method reduce the number of equivalent models, which were derivedfrom inversions of single components and fit the data to a similarmisfit. The 1D results, together with results from other geophysicalmeasurements, serve as the basic model for further 2D forward modelling.The final model depicts a layering that follows the topography of thestrato-volcano. In the depth range of 500 m to 1000 m, the resistivity ofthe layers decreases rapidly downwards into a good conductor withresistivities below 10 OMEGAm. The deepest layer has a resistivity of 0.4OMEGAm which is quantitatively explained with a combination of salinefluids and hydrothermally altered minerals. Furthermore, the final modelsupports a hypothesis from the interpretation of central-loop TEM(Transient Electromagnetic) data that there is a fault structure belowthe southern flank, approximately 7.3 km south of the summit. To thenorth of the fault, the top of the good conductor is lowered from a depthof 500 m to 1000 m. We propose that the fault structure coincides with anancient avalanche caldera rim.

Kalscheuer, T.; Commer, M.; Helwig, S.L.; Hoerdt, A.; Tezkan, B.

2006-02-28

369

Irradiation behavior of bonded structures: radiation induced mixing (RIM) along interfaces  

International Nuclear Information System (INIS)

Radiation damage along interfaces of bonded structures remains an open question for near-, intermediate-, and long-term fusion reactors. One possible mechanism for failure is the intermixing of atomic constituents along interfaces and its consequences. The objective of this work is to quantify the radiation induced mixing (RIM) along interfaces using the Monte Carlo simulation. Mixing layers of hundreds of angstroms thick were calculated between beryllium coating on a semi-infinite iron substrate. In an ITER environment, alterations in the thermal conductivity along the interface reached 20% of its initial value. Also, appreciable modification of the Young's modulus resulted. Thick coatings suffered more mixing. The phenomena resembled the radiation induced segregation (RIS) with its implications on issues like swelling and crack-growth rate. It is expected that thermal, as well as radiation, induced diffusion will broaden the mixing layer. A lack of diffusion data on most candidate fusion materials seriously affects the ability to predict bonded structures behavior at the relevant temperatures. (orig.)

370

The stellar population and complex structure of the bright-rimmed cloud IC 1396N  

CERN Document Server

Context. IC 1396N is a bright-rimmed cloud associated with an intermediate-mass star-forming region, where a number of Herbig-Haro objects, H2 jet-like features, CO molecular outflows, and millimeter compact sources have been observed. Aims. To study in detail the complex structure of the IC 1396N core and the molecular outflows detected in the region and to reveal the presence of additional YSOs inside this globule. Methods. We carried out a deep survey of the IC 1396N region in the J, H, K' broadband filters and deep high-angular resolution observations in the H2 narrowband filter with NICS at the TNG telescope. The completeness limits in the 2MASS standard are Ks~17.5, H~18.5 and J~19.5. Results. A total of 736 sources have been detected in all three bands within the area where the JHK' images overlap. There are 128 sources detected only in HK', 67 detected only in K', and 79 detected only in H. We found only few objects exhibiting a Near-Infrared excess and no clear signs of clustering of sources towards ...

Beltran, M T; López, R; Girart, J M; Estalella, R

2009-01-01

371

THE IMMUNE SYSTEM AND BONE  

OpenAIRE

T cells and B cells produce large amounts of cytokines which regulate bone resorption and bone formation. These factors play a critical role in the regulation of bone turnover in health and disease. In addition, immune cells of the bone marrow regulate bone homeostasis by cross-talking with bone marrow stromal cells and osteoblastic cells via cell surface molecules. These regulatory mechanisms are particularly relevant for postmenopausal osteoporosis and hyperparathyroidism, two common forms ...

Pacifici, Roberto

2010-01-01

372

Normal Bone Anatomy and Physiology  

OpenAIRE

This review describes normal bone anatomy and physiology as an introduction to the subsequent articles in this section that discuss clinical applications of iliac crest bone biopsy. The normal anatomy and functions of the skeleton are reviewed first, followed by a general description of the processes of bone modeling and remodeling. The bone remodeling process regulates the gain and loss of bone mineral density in the adult skeleton and directly influences bone strength. Thorough understandin...

Clarke, Bart

2008-01-01

373

Wnt Signaling in Bone  

Science.gov (United States)

Wnt signaling is involved not only in embryonic development but also in maintenance of homeostasis in postnatal tissues. Multiple lines of evidence have increased understanding of the roles of Wnt signaling in bone since mutations in the LRP5 gene were identified in human bone diseases. Canonical Wnt signaling promotes mesenchymal progenitor cells to differentiate into osteoblasts. The canonical Wnt/?-catenin pathway possibly through Lrp6, a co-receptor for Wnts as well as Lrp5, in osteoblasts regulates bone resorption by increasing the OPG/RANKL ratio. However, endogenous inhibitors of Wnt signaling including sclerostin block bone formation. Regulation of sclerostin appears to be one of the mechanisms of PTH anabolic actions on bone. Since sclerostin is almost exclusively expressed in osteocytes, inhibition of sclerostin is the most promising design. Surprisingly, Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum, but not by directly promoting bone formation. Pharmacological intervention may be considered in many components of the canonical Wnt signaling pathway, although adverse effects and tumorigenicity to other tissues are important. More studies will be needed to fully understand how the Wnt signaling pathway actually influences bone metabolism and to assure the safety of new interventions. PMID:23926379

Kubota, Takuo; Michigami, Toshimi; Ozono, Keiichi

2010-01-01

374

Biodegradable synthetic bone composites  

Science.gov (United States)

The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

Liu, Gao; Zhao, Dacheng; Saiz, Eduardo; Tomsia, Antoni P.

2013-01-01

375

Bone Fractures and Engineering  

Science.gov (United States)

Students learn about the role engineers and engineering play in repairing severe bone fractures. They acquire knowledge about the design and development of implant rods, pins, plates, screws and bone grafts. They learn about materials science, biocompatibility and minimally-invasive surgery.

Integrated Teaching and Learning Program, College of Engineering,

376

Ear and temporal bone  

International Nuclear Information System (INIS)

Radioanatomy of ear and temporal bone is described. Problems of X-ray examination of the diseases of ear and mastoid process (disturbance of ear development, inflammatory diseases, otosclerosis, tumors) are considered. Roentgenoframs of temporal bone of healthy people and that in some diseases are presented and aanalyzed

377

Broken Bones (For Parents)  

Science.gov (United States)

The harder kids play, the harder they fall. The fact is, broken bones , or fractures, are common in childhood and often happen when kids are playing or ... break are out of line), it may be harder to tell. Some telltale signs that a bone ...

378

Pseudoanaplastic tumors of bone  

Energy Technology Data Exchange (ETDEWEB)

To discuss the concept of pseudoanaplastic tumors of bone, which pathologically show hyperchromatism and marked pleomorphism with quite enlarged, pleomorphic nuclei, but with no to extremely rare, typical mitoses, and to propose guidelines for their diagnosis. From a database of 4,262 bone tumors covering from 1971 to 2001, 15 cases of pseudoanaplastic bone tumors (0.35% of total) were retrieved for clinical, radiographic and pathologic review. Postoperative follow-up after surgical treatment was at least 3 years and a maximum of 7 years. There were eight male and seven female patients. Their ages ranged from 10 to 64 years with average of 29.7 years. Pathologic diagnoses of pseudoanaplastic variants of benign bone tumors included: osteoblastoma (4 cases), giant cell tumor (4 cases), chondromyxoid fibroma (3 cases), fibrous dysplasia (2 cases), fibrous cortical defect (1 case) and aneurysmal bone cyst (1 case). Radiography of all cases showed features of a benign bone lesion. Six cases, one case each of osteoblastoma, fibrous dysplasia, aneurysmal bone cyst, chondromyxoid fibroma, giant cell tumor and osteoblastoma, were initially misdiagnosed as osteosarcoma. The remaining cases were referred for a second opinion to rule out sarcoma. Despite the presence of significant cytologic aberrations, none of our cases showed malignant behavior following simple curettage or removal of bony lesions. Our observation justifies the concept of pseudoanaplasia in some benign bone tumors as in benign soft tissue tumors, especially in their late evolutionary stage when bizarre cytologic alterations strongly mimic a sarcoma. (orig.)

Bahk, Won-Jong [Uijongbu St. Mary Hospital, The Catholic University of Korea, Department of Orthopaedic Surgery, Gyunggido, 480-821 (Korea); Mirra, Joseph M. [Orthopaedic Hospital, Orthopedic Oncology, Los Angeles, California (United States)

2004-11-01

379

Solid aneurysmal bone cyst with pathologic bone fracture.  

Science.gov (United States)

A patient is presented with solid aneurysmal bone cyst of the left proximal femur and a pathologic bone fracture in this region. The radiological and histological features of this lesion are described. While a conventional aneurysmal bone cyst is an expanding osteolytic lesion consisting of blood-filled spaces of variable size, separated by connective tissue containing bone trabeculae or osteoid tissue and many osteoclastic giant cells, a solid aneurysmal bone cyst is an unusual solid bone lesion with fibroblastic, osteoclastic, osteoblastic, aneurysmal, and fibromyoxid elements. The differential diagnosis includes giant cell tumor and fibroblastic osteosarcoma as well as specific bone reactions (bone fracture, reparative giant cell granuloma in hyperparathyroidism, giant cell reaction of short tubular bones). Solid aneurysmal bone cyst is a tumor-like lesion and probably a special bone reaction to damage; it has a good prognosis. Usually curettage is curative. PMID:7610415

Adler, C P

1995-04-01

380

[A case of primary intraosseous cavernous hemangioma extending from the orbital rim to the sphenoid wing: a case report].  

Science.gov (United States)

A primary intraosseous cavernous hemangioma located at the sphenoid bone with extensive involvement of the orbital roof and the lateral wall of the orbit is very rare. A 48-year-old woman presented with progressive right exophthalmos and diplopia. CT showed a bony mass lesion in the right sphenoid bone extending to the orbital bone. MRI showed an abnormal lesion in the sphenoid bone, which was heterogeneously enhanced with gadolinium. All of the abnormal bone was surgically removed, and histological examination confirmed a cavernous angioma. We also present a brief clinical and radiological review of seven previously reported cases. PMID:25351802

Inaka, Yasufumi; Otani, Naoki; Nishida, Sho; Kumagai, Kohsuke; Fujii, Kazuya; Ueno, Hideaki; Tomiyama, Arata; Tomura, Satoshi; Osada, Hideo; Wada, Kojiro; Mori, Kentaro

2014-11-01

381

Dystrophic calcinosis cutis and SLE; the bone scan pattern (Case report  

Directory of Open Access Journals (Sweden)

Full Text Available A 21 years old woman presented with a history of SLE and skin lesions on the arms, trunk, and abdomen. The left gluteal region was ulcerated and painful and occasionally extruded a chalky white material. The patient referred from rheumatology department for osteomyelitis assessment. On physical examination the patient had hard, nontender lesions on the proximal arms, lower abdomen and lower back. She had painful, hyper pigmented bullae, plaques, erosions and ulcer on her hands, arms, thighs, knees and especially left gluteal region. All laboratory results including BUN, Cr, Ca, Ph, LFT, were normal except for ESR which was increased. Left gluteal skin biopsy reveals homogenized and sclerotic collagen in the lower dermis with scattered foci of calcification, consistent with calcinosis cutis. The whole body bone scan shows diffuse extra osseous calcification mainly in the arms, lower trunk and thighs. The X-ray findings revealed multiple foci of calcification in the soft tissue compartment of the arms and lower trunk. Focal areas of increased uptake in the ribs and right humerus secondary to osteoporosis and truma were noticed. Calcinosis cutis is a rare presentation of SLE. It is usually seen in CRF and due to electrolyte impairment .In this report however, a case of SLE is presented with extensive calcinosis but normal renal function and lack of any electrolyte imbalance.

B. Fallahi

2004-08-01

382

Deep Drawing for high LDR by a new Hydro-rim Forming Process with Differential Temperature- Analysis and Experiments  

Science.gov (United States)

The purpose of this study is to analyze and test a possible increase of the Limit Drawing Ratio (LDR) in Deep Drawing by Hydro-rim process (a certain subset of the classical Hydroforming) which includes the newly differential temperature effect. The idea is to facilitate the plastic flow by local heating along the flange and to cool the area where strength is needed. The suggested analysis is based on the dual bounds approach (upper and lower bounds simultaneously) using the highly versatile Johnson-Cook constitutive material model. The advantage of combined high hydraulic pressure (about 1000 bar) with relatively high blank temperature (with magnitude of about one third the melting temperature of the considered material) in the same operation is discussed. Emphasis is given to the rule of blank temperature difference (between the flange and the wall of the product) conjugate with optimal hydro rim pressure in increasing the limit drawing ratio of the products (Aluminum, Copper and various Steels).

Simon, Y. Ben; Tirosh, J.; Rubinski, Ludmila

2005-08-01

383

Deep Drawing for high LDR by a new Hydro-rim Forming Process with Differential Temperature- Analysis and Experiments  

International Nuclear Information System (INIS)

The purpose of this study is to analyze and test a possible increase of the Limit Drawing Ratio (LDR) in Deep Drawing by Hydro-rim process (a certain subset of the classical Hydroforming) which includes the newly differential temperature effect. The idea is to facilitate the plastic flow by local heating along the flange and to cool the area where strength is needed. The suggested analysis is based on the dual bounds approach (upper and lower bounds simultaneously) using the highly versatile Johnson-Cook constitutive material model. The advantage of combined high hydraulic pressure (about 1000 bar) with relatively high blank temperature (with magnitude of about one third the melting temperature of the considered material) in the same operation is discussed. Emphasis is given to the rule of blank temperature difference (between the flange and the wall of the product) conjugate with optimal hydro rim pressure in increasing the limit drawing ratio of the products (Aluminum, Copper and various Steels)

384

Ultrasonic bone densitometer  

Science.gov (United States)

A device, for measuring the density of a bone structure so as to monitor the calcium content, is described. A pair of opposed spaced ultrasonic transducers are held within a clamping apparatus closely adjacent the bone being analyzed. These ultrasonic transducers incude piezoelectric crystals shaped to direct signals through the bone encompassed in the heel and finger of the subject being tested. A pulse generator is coupled to one of the transducers and generates an electric pulse for causing the transducers to generate an ultrasonic sound wave which is directed through the bone structure to the other transducer. An electric circuit, including an amplifier and a bandpass filter couples the signals from the receiver transducer back to the pulse generator for retriggering the pulse generator at a frequency proportional to the duration that the ultrasonic wave takes to travel through the bone structure being examined.

Hoop, J. M. (inventor)

1974-01-01

385

Juxtaphyseal aneurysmal bone cysts.  

Science.gov (United States)

Aneurysmal bone cysts are benign primary or secondary lesions that commonly arise in long bones and often before skeletal maturity. Little has been written about aneurysmal bone cysts that abut the physeal plate. The records of 15 patients with juxtaphyseal aneurysmal bone cysts were reviewed. Fourteen of the patients were referred with abnormal radiographs after evaluation for pain in the affected limb. One patient presented with abnormal radiographs after fracture about the aneurysmal bone cyst. None of the patients had evidence of growth plate disruption. The children's ages ranged from 2 to 14 years, with a mean of 9.8 years. There were 10 boys and five girls. Lesion locations included: six in the proximal tibia, three in the distal fibula, two in the distal tibia, two in the proximal femur, one in the distal femur, and one in the distal radius. All of the lesions abutted the physeal plate and fell into one of the types in Campanacci's classification of juxtaphyseal aneurysmal bone cysts. Three lesions were classified as Type 1, eight were Type 2, and four were Type 3. This study included no cases of Type 4 or 5 lesions. Treatment of all lesions consisted of excision, curettage, and bone grafting with care taken to preserve the growth plate. Adjunctive cauterization was performed in two cases. There were no incidences of postoperative physeal plate arrest. Overgrowth of the fibula occurred in one patient. Three patients experienced recurrent lesions. One of the children underwent repeat curettage and bone grafting with no additional recurrence. In the other two children with recurrence, the lesion had grown away from the physeal plate while remaining static in size and asymptomatic. Based on this study, juxtaphyseal aneurysmal bone cysts may be treated satisfactorily with intralesional surgery and bone grafting with expectation of normal physeal growth. PMID:10416410

Rizzo, M; Dellaero, D T; Harrelson, J M; Scully, S P

1999-07-01

386

A tale of two cores: Triggered massive star formation in the bright-rimmed cloud SFO 75  

OpenAIRE

Context. Bright-rimmed clouds (BRCs) are isolated molecular clouds located on the edges of evolved HII regions. Star formation within the BRCs may have been triggered through the propagation of photoionisation-induced shocks driven by the expansion of the HII region. Aims. The main focus of this paper is to investigate the current level of star formation within one of these clouds and evaluate to what extent, if any, star formation may have been triggered. Methods. We present a detailed multi...

Urquhart, J. S.; Thompson, M. A.; Morgan, L. K.; Pestalozzi, M. R.; White, Glenn J.; Muna, D. N.

2007-01-01

387

Self-assembled polymers based on bis-tetra-urea calix[4]arenes connected via the wide rim  

OpenAIRE

Abstract Six double calixarenes were synthesized in which two tetra-urea calix[4]arenes are linked by a rigid spacer between the urea functions at their wide rim. The dimerization of their tetra-urea parts leads to hydrogen bonded polymeric assemblies in apolar solvents. Addition of the stoechiometric amount of a tetra-tosylurea calix[4]arene disrupts the polymeric structures due to the preferred formation of heterodimeric capsules between tetra-aryl and tetra-tosylurea calix[4]are...

2008-01-01

388

RC-IAL: linhagem celular contínua de rim de coelho - características e substrato para replicação de vírus  

OpenAIRE

Uma linhagem celular de rim de coelho (denominada RC-IAL), que foi isolada em 1976, e que atualmente está na 150ª passagem, teve suas características analisadas. As células apresentaram morfologia semelhante aos fibroblastos desde o início de seu cultivo. A proporção de crescimento celular não se alterou desde seu isolamento, com uma eficiência de clonagem ao redor de 9%. A linhagem mostrou crescimento dependente de ancoragem, e a análise cromossômica apresentou o número modal da ...

Cruz Aurea Silveira; Figueiredo Cristina Adelaide; Barbosa Maria Luisa; Martinez Clelia Helena de O.; Salles-Gomes Luís Florêncio

1992-01-01

389

Hyperintense putaminal rim at 1.5?T: prevalence in normal subjects and distinguishing features from multiple system atrophy  

OpenAIRE

Abstract Background Hyperintense putaminal rim (HPR) is an important magnetic resonance imaging (MRI) sign for multiple system atrophy (MSA). Recent studies have suggested that it can also be observed in normal subjects at 3?T. Whether it can be observed in normal subjects at 1.5?T is not known. This study aimed to determine whether HPR could be observed in normal subjects at 1.5?T; and if so, to establish its prevalence, the MRI characteristics, and the features which ...

Tha Khin K; Terae Satoshi; Tsukahara Akiko; Soma Hiroyuki; Morita Ryo; Yabe Ichiro; Ito Yoichi M; Sasaki Hidenao; Shirato Hiroki

2012-01-01

390

Star formation in bright-rimmed clouds and cluster associated with W5 E H{\\sc ii} region  

CERN Document Server

The aim of this paper is to present the results of photometric investigations of the central cluster of the W5 E region as well as a follow-up study of the triggered star formation in and around bright-rimmed clouds (BRCs). We have carried out wide field $UBVI_c$ and deep $VI_c$ photometry of the W5 E H{\\sc ii} region. A distance of $\\sim$2.1 kpc and a mean age of $\\sim$1.3 Myr have been obtained for the central cluster. The young stellar objects (YSOs) associated with the region are identified on the basis of near-infrared and mid-infrared observations. We confirmed our earlier results that the average age of the YSOs lying on/inside the rim are younger than those lying outside the rim. The global distribution of the YSOs shows an aligned distribution from the ionising source to the BRCs. These facts indicate that a series of radiation driven implosion processes proceeded from near the central ionising source towards the periphery of the W5 E H{\\sc ii} region. We found that, in general, the age distributions...

Chauhan, Neelam; Ogura, K; Jose, J; Ojha, D K; Samal, M R; Mito, H

2011-01-01

391

The physical parameters, excitation and chemistry of the rim, jets and knots of the planetary nebula NGC 7009  

CERN Document Server

We present long-slit optical spectra along the major axis of the planetary nebula NGC 7009. These data allow us to discuss the physical, excitation and chemical properties of all the morphological components of the nebula, including its remarkable systems of knots and jets. The main results of this analysis are the following: i) the electron temperature throughout the nebula is remarkably constant, T_e[OIII] = 10200K; ii) the bright inner rim and inner pair of knots have similar densities of N_e = 6000cm^{-3}, whereas a much lower density of N_e = 1500cm^{-3} is derived for the outer knots as well as for the jets; iii) all the regions (rim, inner knots, jets and outer knots) are mainly radiatively excited; and iv) there are no clear abundance changes across the nebula for He, O, Ne, or S. There is a marginal evidence for an overabundance of nitrogen in the outer knots (ansae), but the inner ones (caps) and the rim have similar N/H values that are at variance with previous results. Our data are compared to the...

Gonçalves, D R; Mampaso, A; Perinotto, M; Goncalves, Denise R.; Corradi, Romano L.M.; Mampaso, Antonio; Perinotto, Mario

2003-01-01

392

Challenges, solutions, and best practices in telemental health service delivery across the pacific rim-a summary.  

Science.gov (United States)

The Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, in conjunction with the American Telemedicine Association's Annual Mid-Year Meeting, conducted a 1-day workshop on how maturing and emerging processes and applications in the field of telemental health (TMH) can be expanded to enhance access to behavioral health services in the Pacific Rim. The purpose of the workshop was to bring together experts in the field of TMH from the military, federal agencies, academia, and regional healthcare organizations serving populations in the Pacific Rim. The workshop reviewed current technologies and systems to better understand their current and potential applications to regional challenges, including the Department of Defense and other federal organizations. The meeting was attended by approximately 100 participants, representing military, government, academia, healthcare centers, and tribal organizations. It was organized into four sessions focusing on the following topic areas: (1) Remote Screening and Assessment; (2) Post-Deployment Adjustment Mental Health Treatment; (3) Suicide Prevention and Management; and (4) Delivery of Training, Education, and Mental Health Work Force Development. The meeting's goal was to discuss challenges, gaps, and collaborative opportunities in this area to enhance existing or create new opportunities for collaborations in the delivery of TMH services to the populations of the Pacific Rim. A set of recommendations for collaboration are presented. PMID:23061646

Doarn, Charles R; Shore, Jay; Ferguson, Stewart; Jordan, Patricia J; Saiki, Stanley; Poropatich, Ronald K

2012-10-01

393

Usefulness of {sup 18}F fluoride PET/CT in breast cancer patients with osteosclerotic bone metastases  

Energy Technology Data Exchange (ETDEWEB)

Bone metastasis is an important factor for the treatment and prognosis of breast cancer patients. Whole body bone scintigraphy (WBBS) can evaluate skeletal metastases, and {sup 18}F FDG PET/CT seems to exhibit high specificity and accuracy in detecting bone metastases. However, there is a limitation of {sup 18}F FDG PET in assessing sclerotic bone metastases because some lesions may be undetectable. Recent studies showed that {sup 18}F fluoride PET/CT is more sensitive than WBBS in detecting bone metastases. This study aims to evaluate the usefulness of {sup 18}F fluoride PET/CT by comparing it with WBBS and {sup 18}F FDG PET/CT in breast cancer patients with osteosclerotic skeletal metastases. Nine breast cancer patients with suspected bone metastases (9 females; mean age {+-} SD, 55.6{+-}10.0 years) underwent {sup 99m}Tc MDP WBBS, {sup 18}F FDG PET/CT and {sup 18}F fluoride PET/CT. Lesion based analysis of five regions of the skeletons(skull, vertebral column, thoracic cage, pelvic bones and long bones of extremities) and patient based analysis were performed. {sup 18}F fluoride PET/CT, {sup 18}F FDG PET/CT and WBBS detected 49, 20 and 25 true metastases, respectively. Sensitivity, specificity, positive predictive value and negative predictive value of {sup 18}F fluoride PET/CT were 94.2%, 46.3%, 57.7% and 91.2%, respectively. Most true metastatic lesions of {sup 18}F fluoride PET/CT had osteosclerotic change (45/49, 91.8%), and only four lesions showed osteolytic change. Most lesions on {sup 18}F FDG PET/CT also demonstrated osteosclerotic change (17/20, 85.0%) with three osteolytic lesions. All true metastatic lesions detected on WBBS and {sup 18}F FDG PET/CT were identified on {sup 18}F fluoride PET/CT. {sup 18}F FDG PET/CT in detecting osteosclerotic metastatic lesions. {sup 18}F fluoride PET/CT might be useful in evaluating osteosclerotic metastases in breast cancer patients.

Yoon, Seok Ho; Kim, Ku Sang; Kang, Seok Yun; Song, Hee Sung; Jo, Kyung Sook; Lee, Su Jin; Yoon, Joon Kee; An, Young Sil [Ajou Univ., Suwon (Korea, Republic of); Choi, Bong Hoi [Gyeongsang National Univ. Hospital, Jinju (Korea, Republic of)

2012-03-15

394

Inertial effects at moderate Reynolds number in thin-film rimming flows driven by surface shear  

Science.gov (United States)

In this paper, we study two-dimensional thin-film flow inside a stationary circular cylinder driven by an imposed surface shear stress. Modelling is motivated by a need to understand the cooling and film dynamics provided by oil films in an aero-engine bearing chamber characterised by conditions of very high surface shear and additional film mass flux from oil droplets entering the film through the surface. In typical high-speed operation, film inertial effects can provide a significant leading-order mechanism neglected in existing lubrication theory models. Inertia at leading-order is included within a depth-averaged formulation where wall friction is evaluated similar to hydraulic models. This allows key nonlinear inertial effects to be included while retaining the ability to analyse the problem in a mathematically tractable formulation and compare with other approaches. In constructing this model, a set of simplified mass and momentum equations are integrated through the depth of the film yielding a spatially one-dimensional depth-averaged formulation of the problem. An a priori assumed form of velocity profile is needed to complete the system. In a local Stokes flow analysis, a quadratic profile is the exact solution for the velocity field though it must be modified when inertial effects become important. Extension of the velocity profile to a cubic profile is selected enabling specification of a wall friction model to include the roughness of the cylinder wall. A modelling advantage of including the inertia term, relevant to the applications considered, is that a smooth progression in solution can be obtained between cases of low Reynolds number corresponding to lubrication theory, and high Reynolds number corresponding to uniform rimming-flow. Importantly, we also investigate the effect of inertia on some typical solutions from other studies and present a greater insight to existing and new film solutions which arise from including inertia effects.

Kay, E. D.; Hibberd, S.; Power, H.

2013-10-01

395

Perfluorodecalin and bone regeneration  

Directory of Open Access Journals (Sweden)

Full Text Available Perfluorodecalin (PFD is a chemically and biologically inert biomaterial and, as many perfluorocarbons, is also hydrophobic, radiopaque and has a high solute capacity for gases such as oxygen. In this article we have demonstrated, both in vitro and in vivo, that PFD may significantly enhance bone regeneration. Firstly, the potential benefit of PFD was demonstrated by prolonging the survival of bone marrow cells cultured in anaerobic conditions. These findings translated in vivo, where PFD incorporated into bone-marrow-loaded 3D-printed scaffolds substantially improved their capacity to regenerate bone. Secondly, in addition to biological applications, we have also shown that PFD improves the radiopacity of bone regeneration biomaterials, a key feature required for the visualisation of biomaterials during and after surgical implantation. Finally, we have shown how the extreme hydrophobicity of PFD enables the fabrication of highly cohesive self-setting injectable biomaterials for bone regeneration. In conclusion, perfluorocarbons would appear to be highly beneficial additives to a number of regenerative biomaterials, especially those for bone regeneration.

F Tamimi

2013-01-01

396

Pseudoanaplastic tumors of bone  

International Nuclear Information System (INIS)

To discuss the concept of pseudoanaplastic tumors of bone, which pathologically show hyperchromatism and marked pleomorphism with quite enlarged, pleomorphic nuclei, but with no to extremely rare, typical mitoses, and to propose guidelines for their diagnosis. From a database of 4,262 bone tumors covering from 1971 to 2001, 15 cases of pseudoanaplastic bone tumors (0.35% of total) were retrieved for clinical, radiographic and pathologic review. Postoperative follow-up after surgical treatment was at least 3 years and a maximum of 7 years. There were eight male and seven female patients. Their ages ranged from 10 to 64 years with average of 29.7 years. Pathologic diagnoses of pseudoanaplastic variants of benign bone tumors included: osteoblastoma (4 cases), giant cell tumor (4 cases), chondromyxoid fibroma (3 cases), fibrous dysplasia (2 cases), fibrous cortical defect (1 case) and aneurysmal bone cyst (1 case). Radiography of all cases showed features of a benign bone lesion. Six cases, one case each of osteoblastoma, fibrous dysplasia, aneurysmal bone cyst, chondromyxoid fibroma, giant cell tumor and osteoblastoma, were initially misdiagnosed as osteosarcoma. The remaining cases were referred for a second opinion to rule out sarcoma. Despite the presence of significant cytologic aberrations, none of our cases showed malignant behavior following simple curettage or removal of bony lesions. Our observation justifies the concept of pseudoanaplasia in some benign bone tu of pseudoanaplasia in some benign bone tumors as in benign soft tissue tumors, especially in their late evolutionary stage when bizarre cytologic alterations strongly mimic a sarcoma. (orig.)

397

Lymphangioma of bone  

International Nuclear Information System (INIS)

The patient is a 5-year-old boy, who suffered from frequent pathological fractures in many bones. Roentgenologic examination revealed widely distributed cystic lesions in many bones. Cysts of the same nature were also seen in the soft tissues of the right neck, retroperitoneum and colon. These lesions were composed of many dilated cysts which were lined by a single layer of flat endothelial cells. The over all lesions were considered to be the cystic lymphangiomatosis involving both bone and extraskeletal tissues. The nature of the lesion seems to be a kind of tissue malformation rather than a true neoplasm. (author)

398

Periodontal bone lesions  

International Nuclear Information System (INIS)

In the course of life the periodontum is subject to changes which may be physiological or pathological. Intraoral radiographs give insight into the hard structures of the dentomaxillar region and provides information on lesions in the bone of the periodontum in that they show radiopacities and radiolucencies caused by such lesions. In this thesis the relation is investigated between the true shape and dimensions of periodontal bone lesions and their radiographic images. A method is developed and tested of making standardized and reproducible radiographs suitable for longitudinal studies of periodontal lesions. Also the possibility is demonstrated of an objective and reproducible interpretation of radiographic characteristics of periodontal bone lesions. (Auth.)

399

Outline of bone radiodiagnosis  

International Nuclear Information System (INIS)

The book presents information on the current state of radiodiagnosis in osteology and on radiodiagnostic symptoms of bone processes. Areas are discussed in more detail where basic changes took place in the concept of pathophysiology and symptomatology (e.g., tumors, intrinsic diseases, etc.). The book is intended as a guide for deeper study. It contains over 250 references and many black and white photographs. It is broken down in detailed chapters by the types of bone remodelling, bone injury and the individual pathological alterations. (M.D.). 306 figs., 315 refs

400

Bone scintigraphy for horses  

International Nuclear Information System (INIS)

Scintigraphy (bone scan) is being used approximately since 1980 in the horse under general anaesthesia. With the construction of custom-made overhead gantries for gamma-cameras scintigraphy found widespread entry in big equine referral hospitals for bone-scanning of the standing horse. Indications for the use of a bone scan in the horse are inflammatory alterations in the locomotor apparatus. It is primarily used for diagnosis of lameness of unknown origin, suspect of stress fracture or hairline fracture and for horses with bad riding comfort with suspected painful lesions in the spine. (orig.)

401

Bone changes in endometrosis  

International Nuclear Information System (INIS)

In this study, quantitative CT is used to measure bone in the distal radius in normal women, women with endometriosis who had not been treated, and women with endometriosis who had been treated with danazol--an anabolic (androgen) steroid. Measurements of cortex and trabeculae indicate that untreated women have decreased bone mass (1125 HU and 160 HU, respectively), compared with bone mass in normal women (1269 HU and 257 HU; P < .05) and treated women (1238 HU and 255 HU). This finding is important because the most effective way to reduce the complications of osteoporosis is identification of risk factors, prevention, and early treatment

402

American Society for Bone and Mineral Research: Bone Curriculum  

Science.gov (United States)

Developed by the Education Committee of the American Society for Bone and Mineral Research (ASBMR), this Bone Curriculum website "is intended for use by students from high school to medical school." The website features sections on Bone Cells, Exercise and Nutrition, Hormones that Effect Bone, Collagen and Bone Matrix, and more. The brief text sections are interspersed with great images, diagrams, slide shows, and animations. The site also contains links for related websites, textbooks, and journals.

403

Bone X-Ray (Radiography)  

Medline Plus

Full Text Available X-ray (Radiography) - Bone Play Video Clip (00:04:40) Your Radiologist Explains Bone X-ray What is Bone X-ray ( ... X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive medical ...

404

Bone X-Ray (Radiography)  

Medline Plus

Full Text Available X-ray (Radiography) - Bone Play Video Clip (00:04:40) Your Radiologist Explains Bone X-ray What is ... of Bone X-ray (Radiography)? What is Bone X-ray (Radiography)? An x-ray (radiograph) is a noninvasive ...

405

Genetic analysis of regulatory mutants affecting synthesis of extracellular proteinases in the yeast Yarrowia lipolytica: identification of a RIM101/pacC homolog.  

Science.gov (United States)

Depending on the pH of the growth medium, the yeast Yarrowia lipolytica secretes both an acidic proteinase and an alkaline proteinase, the synthesis of which is also controlled by carbon, nitrogen, and sulfur availability, as well as by the presence of extracellular proteins. Recessive mutations at four unlinked loci, named PAL1 to PAL4, were isolated which prevent alkaline proteinase derepression under conditions of carbon and nitrogen limitation at pH 6.8. These mutations markedly affect mating and sporulation. A dominant suppressor of all four PAL mutations was isolated from a wild-type genomic library, which turned out to be a C-terminally truncated form of a 585-residue transcriptional factor of the His2Cys2 zinc finger family, which we propose to call YlRim101p. Another C-terminally truncated version of YlRim101p (419 residues) is encoded by the dominant RPH2 mutation previously isolated as expressing alkaline protease independently of the pH. YlRim101p is homologous to the transcriptional activators Rim101p of Saccharomyces cerevisiae, required for entry into meiosis, and PacC of Aspergillus nidulans and Penicillium chrysogenum, which were recently shown to mediate regulation by ambient pH. YlRim101p appears essential for mating and sporulation and for alkaline proteinase derepression. YlRIM101 expression is autoregulated, maximal at alkaline pH, and strongly impaired by PAL mutations. PMID:9199331

Lambert, M; Blanchin-Roland, S; Le Louedec, F; Lepingle, A; Gaillardin, C

1997-07-01

406

Alcohol and bone.  

Science.gov (United States)

Alcohol is widely consumed across the world in different cultural and social settings. Types of alcohol consumption differ between (a) light, only occasional consumption, (b) heavy chronic alcohol consumption, and (c) binge drinking as seen as a new pattern of alcohol consumption among teenagers and young adults. Heavy alcohol consumption is detrimental to many organs and tissues, including bones. Osteoporosis is regularly mentioned as a secondary consequence of alcoholism, and chronic alcohol abuse is established as an independent risk factor for osteoporosis. The review will present the different mechanisms and effects of alcohol intake on bone mass, bone metabolism, and bone strength, including alcoholism-related "life-style factors" such as malnutrition, lack of exercise, and hormonal changes as additional causative factors, which also contribute to the development of osteoporosis due to alcohol abuse. PMID:24477631

Mikosch, Peter

2014-01-01

407

Bone healing and osteoporosis.  

Science.gov (United States)

A correct fracture healing depends on the synergy between biomechanical, molecular and cellular factors. Focusing on different stages, fracture hematoma represents the starting point of the inflammatory process, with a critical role in triggering the process of fracture healing. The essential factors for bone repair are the activation of mesenchymal stem cells and the release of growth and regulatory factors. Moreover, the efficacy of fracture healing is determined by three ideal conditions: adequate blood supply, good contact between bone fragments and good stability. It is remarkable how the implant choice influences fracture healing after surgical treatment. In osteoporosis, bone quality adversely affects the tissue structural competence, increasing the risk of a complicated fracture healing. The qualitative and quantitative alterations established at the cellular level during osteoporosis explain the progressive deterioration of bone tissue healing ability. PMID:21970927

Tarantino, Umberto; Cerocchi, Irene; Scialdoni, Alessandro; Saturnino, Luca; Feola, Maurizio; Celi, Monica; Liuni, Federico Maria; Iolascon, Giovanni; Gasbarra, Elena

2011-04-01

408

Temporal bone fractures.  

Science.gov (United States)

This report has illustrated the variety of temporal bone fractures that involve the zygomatic, squamous, and petromastoid components of the temporal bone. Complications as they relate to each type of fracture have been emphasized. Although longitudinal and transverse fractures can be identified, temporal bone trauma usually creates unique fractures constellations that must be individually described. In each case, a careful inspection of the ossides, otic capsule (vestibule/cochlea), internal auditory, and facial nerve canal must be undertaken. When a patient presents with temporal bone fracture and facial nerve paralysis, identification of the site of facial nerve injury may now lead to surgical decompression of this area of the facial nerve canal and possible nerve grafting. PMID:2697341

Dolan, K D

1989-06-01

409

Petrous bone cholesteatoma.  

Science.gov (United States)

Petrous bone cholesteatoma is a rare pathologic entity and may be a difficult surgical challenge because of potential involvement of the facial nerve, carotid artery, dura mater, otic capsule, and risk of cerebrospinal fluid leak. The objective of this article is to present a personal classification of petrous bone cholesteatomas, a survey of recent surgical attitudes, and our present surgical strategy based on our experience with 54 operations between 1978 and 1990. Radical petromastoid exenteration with marsupialization and the middle cranial fossa approach were used only for small pure infra- or supralabyrinthine cholesteatomas, respectively. The enlarged transcochlear approach with closure of the external auditory canal was used for infralabyrinthine, infralabyrinthine-apical, and massive petrous bone cholesteatomas. Five cases with petrous bone cholesteatomas in different locations are described in detail to present the signs and symptoms together with the management. PMID:17170912

Sanna, M; Zini, C; Gamoletti, R; Frau, N; Taibah, A K; Russo, A; Pasanisi, E

1993-01-01

410

Menopause and Bone Loss  

Science.gov (United States)

... density test (DeXa scan). this test gives exact measurements of the density (or thickness) of the bone ... therapy (estrogen only, or, if you have a uterus, combined estrogen plus progestin) in some women for ...

411

Diffuse lymphangiomatosis of bone  

International Nuclear Information System (INIS)

Two cases of lymphangiomatosis of bone, a very rare systemic condition characterised by both skeletal and parenchymal lesions, are presented. The skeletal changes have an appearance similar to haemangiomas in the spine, and soap-bubbly lesions in the flat bones. One case carried the diagnosis of eosinophilic granuloma for 18 years. The findings on MRI, which have not been previously well-established, are discussed. Copyright (1999) Blackwell Science Pty Ltd

412

Antiepileptics and Bone Health  

OpenAIRE

In recent years there has been increasing evidence suggesting that epilepsy and its treatment can have adverse effects on bone mineralization and calcium metabolism. Many studies have shown a significant reduction in bone mineral density (BMD) and an increased fracture risk in patients treated with enzyme-inducing antiepileptics (phenobarbital, carbamazepine, phenytoin). It is assumed that CYP450-inducing antiepileptic drugs (AEDs) upregulate the enzymes which are responsible for vitamin D me...

Meier, Christian; Kraenzlin, Marius E.

2011-01-01

413

Wnt Signaling in Bone  

OpenAIRE

Wnt signaling is involved not only in embryonic development but also in maintenance of homeostasis in postnatal tissues. Multiple lines of evidence have increased understanding of the roles of Wnt signaling in bone since mutations in the LRP5 gene were identified in human bone diseases. Canonical Wnt signaling promotes mesenchymal progenitor cells to differentiate into osteoblasts. The canonical Wnt/?-catenin pathway possibly through Lrp6, a co-receptor for Wnts as well as Lrp...

Kubota, Takuo; Michigami, Toshimi; Ozono, Keiichi

2010-01-01

414

Bone changes in leprosy  

International Nuclear Information System (INIS)

Bone lesions is a frequent organic manifestation in leprosy. Osseal destructions caused by granulomatous process induced by M. leprae are so-called specific lesions in contrast to non specific lesions based on nerval or arterial diseases. The specific osseal alterations are characterized by cystic brightenings in roentgenograms while non specific osseal changes show absorption to bone structure as akroosterolysis and osteoporosis. Typical radiologic findings in different stages of mutilation are demonstrated. (orig.)

415

Steroid hormones and bone  

OpenAIRE

Steroid hormones have an important impact on bone. The mechanism of steroid action on bone cells is through an interaction with specific receptor proteins in the target cells. Steroid receptors are a class of molecules that function as both signal transducers and transcription factors. The receptors each have similar functional domains that are responsible for discrete functions. The mechanism of receptor action is mediated by both genomic and nongenomic pathwa...

Huang, W. H.; Zheng, M. H.

1999-01-01

416

Bone marrow suppressing agents  

International Nuclear Information System (INIS)

The invention concerns a method for suppressing bone marrow which comprises administering to a mammal at least one bone marrow suppressing complex of a radionuclide selected from Samarium-153, Gadolinium-159, Holmium-166 and Yttrium-90 and at least one macrocyclic aminophosphonic acid ligand containing the 1,4,7,10-tetraazacyclododecane moiety, or a physiologically acceptable salt thereof. Suitable compositions for use in this method are provided

417

Uranium in fossil bones  

International Nuclear Information System (INIS)

An attempt has been made to determine the uranium content and thus the age of certain fossil bones Haritalyangarh (Himachal Pradesh), India. The results indicate that bones rich in apatite are also rich in uranium, and that the radioactivity is due to radionuclides in the uranium series. The larger animals apparently have a higher concentration of uranium than the small. The dating of a fossil jaw (elephant) places it in the Pleistocene. (Auth.)

418

Bone scan in pediatrics  

International Nuclear Information System (INIS)

In 1984, a survey carried out in 21 countries in Europe showed that bone scintigraphy comprised 16% of all paediatric radioisotope scans. Although the value of bone scans in paediatrics is potentially great, their quality varies greatly, and poor-quality images are giving this valuable technique a bad reputation. The handling of children requires a sensitive staff and the provision of a few simple inexpensive items of distraction. Attempting simply to scan a child between two adult patients in a busy general department is a recipe for an unhappy, uncooperative child with the probable result of poor images. The intravenous injection of isotope should be given adjacent to the gamma camera room, unless dynamic scans are required, so that the child does not associate the camera with the injection. This injection is best carried out by someone competent in paediatric venipunture; the entire procedure should be explained to the child and parent, who should remain with child throughout. It is naive to think that silence makes for a cooperative child. The sensitivity of bone-seeking radioisotope tracers and the marked improvement in gamma camera resolution has allowed the bone scanning to become an integrated technique in the assessment of children suspected of suffering from pathological bone conditions. The tracer most commonly used for routine bone scanning is 99mTc diphosphonate (MDP); other isotopes used include 99mTc colloid for bone marrow scans a9mTc colloid for bone marrow scans and 67Ga citrate and 111In white blood cells (111In WBC) for investigation of inflammatory/infective lesions

419

Petrous Bone Cholesteatoma  

OpenAIRE

Petrous bone cholesteatoma is a rare pathologic entity and may be a difficult surgical challenge because of potential involvement of the facial nerve, carotid artery, dura mater, otic capsule, and risk of cerebrospinal fluid leak. The objective of this article is to present a personal classification of petrous bone cholesteatomas, a survey of recent surgical attitudes, and our present surgical strategy based on our experience with 54 operations between 1978 and 1990. Radical petromastoid exen...

Sanna, Mario; Zini, Carlo; Gamoletti, Roberto; Frau, Niccolo?; Taibah, Abdel Kader; Russo, Alessandra; Pasanisi, Enrico

1993-01-01

420

Bone scans in neuroblastoma.  

Science.gov (United States)

Eighty-Six patients of neuroblastoma ranging in age from four months to 15 years were studied with 99m Tc-MDP for total skeletal survey over a period of seven years (1983-1990). The diagnosis of neuroblastoma was based on bone marrow examination, FNAC, lymph node biopsy, histopathology. Bone imaging was performed three hrs. after intravenous administration of 99m Tc-MDP. Out of 86 patients, 45 patients had positive bone scan showing osseous concentration in 122 sites and extraosseous concentration in 34 sites. Seven patients had liver metastases. None of these liver metastases showed concentration of MDP. Fourteen patients underwent surgery for the primary tumour at the time of bone scanning. Ten patients were studied at the time of follow up, of which four patients showed good response as bony metastases were not demonstrated on bone scintigraphy and X-rays. In conclusion, bone scan is an useful test in neuroblastoma in delineating the bony metastases and also in assessing the efficacy of chemotherapy in these patients. PMID:8500809

Bhogate, B M; Samuel, A M; Ramanathan, P

1993-03-01

421

Bone Remodeling Monitor  

Science.gov (United States)

The impact of bone loss due to different mechanical loadings in microgravity is a major concern for astronauts upon reintroduction to gravitational forces in exploration missions to the Moon and Mars. it has been shown that astronauts not only lose bone at differing rates, with levels up to 2% per month, but each astronaut will respond to bone loss treatments differently. Pre- and post-flight imaging techniques and frozen urine samples for post-flight laboratory immunoassays To develop a novel, non-invasive, highly . sensitive, portable, intuitive, and low-powered device to measure bone resorption levels in 'real time' to provide rapid and Individualized feedback to maximize the efficacy of bone loss countermeasures 1. Collect urine specimen and analyze the level of bone resorption marker, DPD (deoxypridinoline) excreted. 2. Antibodies specific to DPD conjugated with nanoshells and mixed with specimen, the change in absorbance from agglutination is measured by an optical device. 3. The concentration of DPD is displayed and recorded on a PDA

Foucar, Charlie; Goldberg, Leslie; Hon, Bodin; Moore, Shannon; Williams, Evan

2009-01-01

422

Bone Tissue Engineering  

Directory of Open Access Journals (Sweden)

Full Text Available The requirement for new bone to replace or restore the function of damaged or lost bone is a major clinical and social need. Bone tissue engineering has been considered as the alternative strategy to produce artificial bone grafts. The strategy of the method is to combine progenitor or mature cells isolated from desired cell source with biodegradable scaff