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1

Detection of sclerotic bone metastases in the spine using watershed algorithm and graph cut  

Science.gov (United States)

The early detection of bone metastases is important for determining the prognosis and treatment of a patient. We developed a CAD system which detects sclerotic bone metastases in the spine on CT images. After the spine is segmented from the image, a watershed algorithm detects lesion candidates. The over-segmentation problem of the watershed algorithm is addressed by the novel incorporation of a graph-cuts driven merger. 30 quantitative features for each detection are computed to train a support vector machine (SVM) classifier. The classifier was trained on 12 clinical cases and tested on 10 independent clinical cases. Ground truth lesions were manually segmented by an expert. The system prior to classification detected 87% (72/83) of the manually segmented lesions with volume greater than 300 mm3. On the independent test set, the sensitivity was 71.2% (95% confidence interval (63.1%, 77.3%)) with 8.8 false positives per case.

Wiese, Tatjana; Yao, Jianhua; Burns, Joseph E.; Summers, Ronald M.

2012-02-01

2

Solitary sclerotic fibroma of the skin: a sclerotic dermatofibroma?  

Science.gov (United States)

Two cases of solitary tumors showing well-demarcated hypocellular, dermal fibrocollagenous proliferations are reported. The lesions were composed of hyalinized eosinophilic collagen bundles arranged in the characteristic interwoven pattern with prominent clefts, as described in sclerotic fibroma of the skin. This pattern, although predominant, was not uniform. Some areas showed a more cellular pattern with histopathologic features suggestive of dermatofibroma. In those areas, multiple spindle-shaped cells and occasional multinucleated cells were observed. The collagen bundles did not adopt a whorled pattern, and the overlying epidermis showed mild acanthosis and elongation of the rete ridges. The sclerotic changes were present mainly at the periphery and in the deep areas of the tumor. Our observations confirm the possibility that solitary sclerotic fibroma of the skin may represent, at least in some instances, the later and sclerotic stage of other more cellular neoplasms (specifically dermatofibromas) rather than an individualized neoplasm, as has been recently proposed. PMID:8989937

Pujol, R M; de Castro, F; Schroeter, A L; Su, W P

1996-12-01

3

A study on the healing process of bone defect-examination of healing stages of bone defect in the irradiated mandibular rim by microradiography and autoradiography  

International Nuclear Information System (INIS)

The mandibular rim of 150 female Donryu strain rats was exposed to 2000 rads (B group) or to 3000 rads (C group), and a bone defect of 1 x 1 x 2 mm in size was formed in the madibular rim. Cure process of this bone defect was observed periodically by microradiography and autoradiography using "4"5Ca as a tracer, compared with that in the control group (A group, non-irradiated). Irradiated rats having bone defects recovered smoothly. Microradiographic findings of the A group showed that new bone was formed on the surface of the perosteum of the mandible on the 7th days after the irradiation. Bone defects in all rats were repaired completely by the 49th days after the irradiation. Microradiographic findings of the B and C groups showed that new bone was formed on the tongue side surface of the periosteum of the mandible in the early stage after the irradiation. However, after that, osteogenesis became slower, and the edge of bone defects or a part of the mandible became smaller. Bone defects were not repaired and became larger. These findings were more marked in the C group than in the B group. Autoradiographic findings showed marked uptake of "4"5Ca into new bone in the A group. Rats of which bone defects were repaired showed the uptake of "4"5Ca in accordance with the shape of the mandibular rim. The edge of bone defect of the B and C groups where new bone was not formed was destroyed since the 14th day after the irradiation. There were some cases in which the uptake of "4"5Ca into the surface of the periosteum of the mandible near bone defect was observed even when bone defect was enlarged. (Tsunoda, M.)

1980-01-01

4

Innumerable Small Bony Nodular Sclerotic Lesions with Negative Findings on Both Bone Scintigraphy and F-18 FDG PET: Osteopoikilosis a Patient of Breast Cancer  

International Nuclear Information System (INIS)

Osteopoikilosis is a rare, benign hereditary disease, which presents multiple osteosclerotic, and small round nodules in the bone. It is usually detected incidentally by radiological examination. A radionuclide bone scintigraphy is essential in distinguishing osteopoikilosis from osteoblastic metastases, because scintigraphic findings are usually normal in patients with osteopoikilosis. However, there have been no reports about F-18 fluorodeoxyglucose (FDG) PET findings in osteopoikilosis. Herein, we wish to report a case of osteopoikilosis with breast cancer, which could not be seen in either bone scintigraphy or F-18 FDG PET/CT

2008-06-01

5

Innumerable Small Bony Nodular Sclerotic Lesions with Negative Findings on Both Bone Scintigraphy and F-18 FDG PET: Osteopoikilosis a Patient of Breast Cancer  

Energy Technology Data Exchange (ETDEWEB)

Osteopoikilosis is a rare, benign hereditary disease, which presents multiple osteosclerotic, and small round nodules in the bone. It is usually detected incidentally by radiological examination. A radionuclide bone scintigraphy is essential in distinguishing osteopoikilosis from osteoblastic metastases, because scintigraphic findings are usually normal in patients with osteopoikilosis. However, there have been no reports about F-18 fluorodeoxyglucose (FDG) PET findings in osteopoikilosis. Herein, we wish to report a case of osteopoikilosis with breast cancer, which could not be seen in either bone scintigraphy or F-18 FDG PET/CT.

Jun, Sung Min; Kim, Yong Ki; Kim, In Ju; Nam, Hyun Yeol; Kim, Bum Soo [Pusan National University Hospital, Pusan (Korea, Republic of)

2008-06-15

6

Bone disease of primary hyperoxaluria in infancy  

International Nuclear Information System (INIS)

A patient with primary hyperoxaluria type I in infancy is reported. He had renal insufficiency, but urolithiasis was absent. Demonstration of diffuse nephrocalcinosis by renal ultrasound contributed to early diagnosis. Prolonged survival leads to extensive extrarenal oxalate deposition. Repeated skeletal surveys showed the development and the progression of severe hyperoxaluria-related bone disease. Translucent metaphyseal bands with sclerotic margins, wide areas of rarefaction at the ends of the long bones, and translucent rims around the epiphyses and the tarsal bones were signs of disordered bone growth. Bone density generally increased with time indicating progressive sclerosis due to oxalate deposition in the previously normal bone structure. (orig.)

1989-01-01

7

Morphology of autogenous bone graft and castor oil polyurethane in the infraorbital rim of rabbits: a comparative study  

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Full Text Available PURPOSE: Morphological study comparing castor oil polyurethane and autogenous bone graft to repair bone defect in zygomatic bone of rabbits. METHODS: Twenty-four adult, male New Zealand rabbits were randomly distributed between two groups of twelve. Bone defects of 5mm in diameter were cut through the zygomatic bone and filled with polyurethane discs in the experimental group or autogenous bone harvested from the tibia in the control group. Animals were sacrificed after 30, 60 or 90 days, and the zygomatic bones were macro- and microscopically analyzed. Student's, Fisher's, chi-squared and McNemar's tests were used for statistical analysis. RESULTS: Both the castor oil polyurethane and the autograft adapted well to the defect, with no need for fixation. Fibrous connective tissue encapsulated the polyurethane, but no inflammation or giant cell reaction was observed. Acidophilic and basophilic areas were observed inside the micropores of the polyurethane, suggesting cell nuclei. After 90 days, bone repair with a lamellar pattern of organization was observed in the control group. CONCLUSION: The castor oil polyurethane was biocompatible and did not cause inflammation. It may be considered an alternative to fill bone defects.

Mendonça José Carlos Garcia de

2006-01-01

8

Imaging diagnosis of the juxta-articular bone cyst  

International Nuclear Information System (INIS)

Objective: To investigate the imaging features of the juxta-articular bone cyst(intra- osseous ganglia). Methods: The imaging findings of 54 cases histopathologically confirmed were studied retrospectively. X-ray, CT, and MRI were performed in 46 eases, 30 cases, and 14 cases, respectively. Results: Of the 54 cases, 27 arised from the ankle (including multiple lesions), 16 from the knee joint, 7 from the hip joint, 1 from the proximate end of the humerus, ulna, trapezium bone, the first phalange in each, and 1 from the talus and the distal end of the tibia. There were 43 cases (44 lesions) in the ankle and knee joints, with 29 (65.9%) lesions located in the medial articular surface. Fifty-four cases had thinning sclerotic rim, showing a unilocular round osteolytic appearance in 44 cases and a multiloculated-cystic appearance with septa in 10 cases. Discontinuous articular surface were seen in 15 cases, reticular surface collapse in 1, gas density in 3 and fluid-fluid plane in 1. (1) On x-ray films, 46 cases (47 lesions) with well-defined sclerotic rim revealed round, arch or irregular lyric areas at the adjacent articular surface. The fissures were found at the adjacent articular surface in 6 lesions. No joint spaces were abnormal. (2)On CT, 30 cases with sclerotic rim showed round in 19 lesions, arch in 3, and irregular in 8. The fissures were seen at the adjacent articular surface in 14 lesions. The density showed homogeneous in 27 lesions, and gas existed in 3. (3) Fourteen cases (15 lesions)showed hypointense to isointense signal on MR T1WI and hyperintense signal on T2WI. Fluid-fluid plane was found in 1 case. The fissures were observed at the adjacent articular surface in 8 lesions. 7 cases showed swelling soft tissue. Conclusion: The characteristic locations combined with the typical imaging features may suggest the diagnosis of jaxta-articular bone cyst. (authors)

2008-11-01

9

A solitary lesion of talus with mixed sclerotic and lytic changes: Rosai-Dorfman disease of 25 years' duration  

International Nuclear Information System (INIS)

Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is an unusual form of histiocytic disorder predominantly affecting children and young adults. Bone lesions are infrequent. We describe a 63-year-old woman with a solitary lesion of the talus which was misdiagnosed for 25 years. The patient never had adenopathy or other organ involvement. The radiographic findings were a mixture of sclerotic and lytic changes, an extremely rare and unusual presentation of the disease. (orig.)

2004-04-01

10

T-tube insertion for sclerotic subglottic stenosis.  

Science.gov (United States)

T-tube insertion is effective treatment for subglottic stenosis, but it is generally difficult due to bending of the T-tube. In a 52-year-old woman with relapsing polychondritis, a T-tube was inserted after predilatation using Hegar dilators. We describe the details of our T-tube insertion methods for sclerotic subglottic stenosis. PMID:24585799

Goto, Taichiro; Kato, Ryoichi

2014-02-01

11

The sclerotic pedicle - how many causes are there?  

International Nuclear Information System (INIS)

The sclerotic pedicle is a commonly encountered roentgen sign that may be associated with numerous conditions, both benign and malignant. The following paper discusses the common as well as the unusual causes of this interesting phenomenon and demonstrates the radiographic presentations of the various etiologies. (orig.)

1990-01-01

12

Fiber composite flywheel rim  

Science.gov (United States)

A flywheel 2 comprising a hub 4 having at least one radially projecting disc 6, an annular rim 14 secured to said disc and providing a surface circumferential to said hub, a first plurality of resin-impregnated fibers 22 wound about said rim congruent to said surface, and a shell 26 enclosing said first plurality of fibers and formed by a second plurality of resin-impregnated fibers wound about said rim tangentially to said surface.

Davis, Donald E. (Thousand Oaks, CA); Ingham, Kenneth T. (Woodland Hills, CA)

1987-01-01

13

Dopamine-Mediated Sclerotization of Regenerated Chitin in Ionic Liquid  

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Full Text Available Chitin is a promising structural material for biomedical applications, due to its many advantageous properties and abundance in nature. However, its usage and development in the biomedical field have been stagnant, because of chitin’s poor mechanical properties in wet conditions and the difficulties in transforming it into an applicable form. To overcome these challenges, we created a novel biomimetic chitin composite. This regenerated chitin, prepared with ionic liquid, showed improved mechanical properties in wet conditions by mimicking insect cuticle and squid beak sclerotization, i.e., catechol-meditated cross-linking. By ionic liquid-based heat treatment, dopamine oxidation produced melanin-like compounds and dopamine-meditated cross-links without any solvent evaporation and oxidant utilization. The dopamine-meditated sclerotization increased the ultimate tensile strength (UTS of the regenerated chitin by 2.52-fold, measured after six weeks of phosphate-buffered saline (PBS submersion. In addition, the linear swelling ratio (LSR of the chitin film was reduced by about 22%. This strategy raises a possibility of using regenerated chitin as an artificial hard tissue in wet conditions.

Dongyeop X. Oh

2013-09-01

14

Peritumoral bone marrow edema accompanying benign giant cell tumor  

International Nuclear Information System (INIS)

To evaluate the frequency of peritumoral bone marrow(BM) edema accompanying benign giant cell tumor(GCT) of the appendicular bone by magnetic resonance(MR) imaging and to correlate MRI findings with those of plain radiography and bone scintigraphy. Eighteen cases of pathologically proven benign GCT of the appendicular bone were retrospectively analyzed using MR images, plain radiographs and bone scintigrams. A plain radiography was available in 15 cases, and a scintigram in six. Marrow edema was defined as peritumoral signal changes which were of homogeneous intermediate or low signal intensity(SI) onT1WI and high SI on T2WI, relative to the SI of normal BM, and homogeneous enhancement on Gd-DTPA -enhanced T1WI. The transition zone, sclerotic margin and aggressiveness of the lesion were assessed on the basis of plain radiographs. BM edema seen on MR images was correlated with plain radiographic and scintigraphic findings. 1. Peritumoral BM edema was seen on MR images in 10 of 18 cases (55.5%). 2. In 8 of 15 cases for which plain radiographs were available, MR imaging revealed BM edema. In six of these eight, transition zone was wide, while in two it was narrow. Six of seven patients without marrow edema showed a wide transition zone, and in one this was narrow. There was significant correlation between BM edema shown by MR imaging and the transition zone seen on plain radiographs (x2, p<0.05). But the aggressiveness shown by plain radiographs correlated only marginally while the presence of sclerotic rim did not correlate. 3. All six cases for which a bone scintigram was available showed an extended uptake pattern. In five of the six, MR imaging revealed edema. Peritumoral BM edema was frequently seen (55.5%) in the GCTs of appendicular bone; it was more often shown in association with a wide transition zone by plain radiographs.=20

1998-10-01

15

Image and pathology of the bone infarct  

International Nuclear Information System (INIS)

Objective: To investigate the progressing of pathology and the characteristic findings on plain radiography, CT and MR imaging of the bone infarct. Methods: Five out of 6 patients were examined by plain radiography, four by CT, and three by MRI. Results: Ten sites of the bone infarct in 6 patients were found, including 4 in the distal femur, 4 in the proximal tibia, 1 in the distal tibia, and 1 in the femoral neck and tuberosity. The lesion sites in 2 patients were confirmed by operation and pathology. Plain radiography manifestation was inhomogeneous ossification in the intramedullary cavity. CT manifestation was 'map-shaped' lesions with the surrounding sclerotic rim in the intramedullary cavity. MRI showed that the lesions consisted of three zones, the center was the necrotic tissues of the bone and bone marrow, the surrounding part was the partially necrotic tissues of the bone and bone marrow, and the outer most part was the reactive bone tissue and the granulation tissue. The bone infarct occurred in the metaphysis of the right distal tibia associated with the premature epiphyseal closure in one patient. According to the animal fracture-healing experiments preceding, authors speculated that the bone infarct resulted from the venous sinus obstruction. Conclusion: MRI is the most effective way to examine and find the bone infarct in the early stags. Plain radiography was helpful to diagnose the bone infarct in the middle and later stages. CT examination is more sensitive than plain radiography. Plain radiography, CT and MR imaging should be combined in diagnosing the bone infarct

2004-03-01

16

A solitary lesion of talus with mixed sclerotic and lytic changes: Rosai-Dorfman disease of 25 years' duration  

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Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is an unusual form of histiocytic disorder predominantly affecting children and young adults. Bone lesions are infrequent. We describe a 63-year-old woman with a solitary lesion of the talus which was misdiagnosed for 25 years. The patient never had adenopathy or other organ involvement. The radiographic findings were a mixture of sclerotic and lytic changes, an extremely rare and unusual presentation of the disease. (orig.)

Abdelwahab, Ibrahim Fikry [Department of Radiology, New York Methodist Hospital Affiliated with Weill Medical College of Cornell University, 506 Sixth Street, NY 11215, Brooklyn (United States); Klein, Michael J. [Department of Pathology, Mount Sinai Medical Center, 1 Gustave Levy Place, NY 10029, New York (United States); Springfield, Dempsey S. [Department of Orthopedics, Mount Sinai Medical Center, 1 Gustave Levy Place, NY 10029, New York (United States); Hermann, George [Department of Radiology, Mount Sinai Medical Center, 1 Gustave Levy Place, NY 10029, New York (United States)

2004-04-01

17

Wide Rim Microchannel Plates.  

Science.gov (United States)

Wide rim 18 mm microchannel plates were successfully manufactured during this contract. The necessary modifications to fixturing and equipment to accomplish the program objectives are detailed in this report. Adjustments to hydrogen firing and vacuum baki...

R. Layman C. Sicora

1977-01-01

18

Multifocal sclerotic BCG spondylitis in a 13-year-old girl  

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A case is reported of multifocal BCG osteomyelitis in a 13-year-old girl. The lesions in the skull, ribs and in several vertebrae were mainly sclerotic and healed with antituberculotic therapy. The case is unusual because of the late onset, sclerotic changes, and involvement of the spine.

Sandstroem, S.

1983-06-01

19

Imaging features and diagnostic value of bone lipoma  

International Nuclear Information System (INIS)

Objective: To study the imaging manifestations of bone lipoma and their diagnostic value. Methods: Ten cases with pathologically proved lipoma of bone were analyzed, and the literature was reviewed. Results: Eight of 10 cases were intraosseous lipomas which were located in the femoral neck (1 case), the femoral neck-intertrochanter area (1 case), the acetabulum (4 cases) and the calcaneus (2 cases), respectively. All foci showed oval or irregular radiolucent area on X-ray film and adipose tissue area with thin or thick sclerotic rim on CT images. The fat attenuation values within the lesion were in the range of -22 to - 120 Hounsfield units. Focal intralesional calcifications in the center or margin within the intraosseous lipoma were present in 6 foci. The other 2 cases were juxtacortical lipomas, which showed the irregular adipose tissue area beside bone with reactive bony proliferation. Conclusion: The lipoma of bone has common imaging features, that is, mainly composed of fatty tissue. However, the imaging manifestations of bone lipoma in different locations are somewhat different, and they could be diagnosed correctly before operation by using CT. (authors)

2006-06-01

20

Citric acid etching of cervical sclerotic dentin lesions: an AFM study.  

Science.gov (United States)

Atomic force microscopy (AFM) has been used to determine microstructural changes, etching rates of peritubular dentin, and intertubular dentin recession during demineralization in dilute acidic solutions. These studies have not included many forms of altered dentin, including noncarious sclerotic root dentin associated with Cl V (abfraction) lesions. We sought to determine microstructural changes and recession rates during demineralization in citric acid (pH 2.5, 0.018M) for the transparent/sclerotic zone. Highly polished dentin disks were prepared from teeth with noncarious C1 V lesions (n = 3) and compared with normal root dentin (n = 3). Samples were etched at 5-s intervals for 1 min and at longer intervals up to 30 min. The depth changes in various portions of the dentin with respect to the reference layer were measured and changes in microstructure observed in solution in the wet cell of the AFM. In sclerotic dentin, most tubule lumens were occluded with crystalline deposits that etched more slowly than the other dentin components, but etching rates could not be determined due to their irregular geometry. The intertubular dentin recession quickly reached a plateau after a depth change of etching of sclerotic intertubular dentin and that of non-sclerotic root dentin that became apparent after 600 s (p = 0.037). The sclerotic intertubular dentin underwent less depth change at the plateau (558 nm) compared to normal root dentin (744 nm). In addition, normal root dentin underwent significantly greater recession than coronal dentin (p = 0.002). The results of this study indicate that intertubular sclerotic dentin from Cl V lesions etches differently than normal root dentin, and this may help explain the difficulties in restoring such lesions with current bonding procedures. PMID:10602066

Marshall, G W; Chang, Y J; Saeki, K; Gansky, S A; Marshall, S J

2000-03-01

 
 
 
 
21

Microorbitalism: a technique for orbital rim expansion.  

Science.gov (United States)

A simple technique for orbital aperture expansion to facilitate placement of ocular prostheses is described. Both superolateral and inferolateral orbital margins are released by means of a single burr hole craniectomy of the frontosphenoid bone behind the orbital process of the frontal bone. Vertical and horizontal marginal lengthenings are performed by a rotatory displacement of one bone segment alongside the other. The expanded osseous aperture is secured with wire and plate-and-screw fixation following a supraorbital rim craniectomy to allow an adequate fit. The result provides for easier access of ocular prostheses and tissue expanders. The method has been applied to a series of patients with microorbitalism due to unilateral or bilateral congenital anophthalmia over the past 3 years without complication and with excellent results. Three-dimensional re-formatted CT reconstructions of the craniofacial skeleton are shown preoperatively and postoperatively. PMID:1896532

Elisevich, K; Bite, U; Colcleugh, R

1991-10-01

22

Contraction gap versus shear bond strength of dentin adhesive in sound and sclerotic dentins.  

Science.gov (United States)

To evaluate the effect of a dentin adhesive on sclerotic dentin, contraction gap width and shear bond strength were measured. Dentin cavity wall was pretreated with an experimental dentin bonding system with and without a dentin primer, or with a commercial dentin bonding system. In the experimental dentin bonding groups, contraction gap width of sclerotic dentin was significantly smaller than that of sound dentin when the cavity was not primed with glyceryl monomethacrylate. For each individual tooth, the correlation between contraction gap width and shear bond strength was insignificant. In conclusion, the bonding efficacy of dentin bonding systems to sclerotic dentin was superior to that of sound dentin. Further, it was determined that it was impossible to detect the interaction between the polymerization contraction stress of resin composites and the efficacy of dentin adhesives by measuring bond strength. PMID:17076330

Kusunoki, Mizuho; Itoh, Kazuo; Takahashi, Yoichi; Hisamitsu, Hisashi

2006-09-01

23

The lucent rim: a radiographic and computed tomography sign of Paget's disease of the skull  

International Nuclear Information System (INIS)

In seven of eight patients with osteoporosis circumscripta of the cranial vault, the pagetic bone lacunae were separated from the normal bone by a lucent rim visible on conventional radiographs and computed tomography scans. The contour of the rim was sharp on the side of the healthy surrounding bone and hazy on the side of the defect. To our knowledge, this sign has been reported in one single previous article dealing with two pagetic patients with the bisphosphonate escape phenomenon. (orig.)

2006-06-01

24

Quantification of sclerotic renal glomeruli during the aging process in humans  

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Full Text Available Introduction. The aim of our research was to quantify the presence of totally sclerotized glomeruli during the aging process. Material and Methods. The study material were kidney tissue samples taken from fiftysix cadavers, their age ranging from 20 to over 70 years. They were classified in six age groups: I (20-29, II (30-39, III (40-49; IV (50-59; V (60-69 and VI (older than 70. The tissue samples were routinely histologically processed and then cut into the slices 5 mm thick, which were then stained and stereologically analyzed under the microscope with a projection screen (Reichert Visopan with 10 x lens magnification and multipurpose test system M42 application. The analysis was carried out on 20 fields of vision per one sample. The numerical density of completely sclerotic and other glomeruli was measured, and the resulting percentages were obtained from this parameter. Results. Completely sclerotic glomeruli were not found in the first group. They were observed in the II aging group (5% for the first time. Their numerical density and percentage increased during the aging process and was 18% in the IV, 25% in the V and maximally 37.5% in the VI aging group. Conclusion. Finally, the above cited results pointed to the increase of completely sclerotized and the decreased presence of normal glomeruli during the aging process

Pavlovi? Snežana

2010-01-01

25

Vertebral sarcoidosis: demonstration of bone involvement by computerized axial tomography  

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A report is given of a rare case of vertebral sarcoidosis with negative conventional spinal x-ray films, yet with typical cystic lesions of the spine found incidentally during abdominal computerized axial tomography (CAT). The patient was a 28-year-old black man, who was admitted for evaluation of a 1 1/2-year history of diffuse myalgias, intermittent fever to 102 F orally, bilateral hilar adenopathy, and leukopenia. A technetium polyphosphate bone scan revealed diffuse areas of increased uptake over the sternum, entire vertebral column, and pelvis. Conventional x-ray films of the cervical, thoracic, and lumbar spine, and an AP view of the pelvis were all normal. Chest x-ray film revealed only bilateral hilar adenopathy. During the course of an extensive negative evaluation for infection, an abdominal CAT scan was done, showing multiple, small, sclerotic-rimmed cysts at multiple levels of the lower thoracic and lumbar spine. Bone marrow biopsy revealed only changes consistent with anemia of chronic disease. Mediastinal lymph node biopsy revealed noncaseating granulomas. A tentative diagnosis of sarcoidosis was made, and treatment with prednisone, isoniazid and rifampin was begun. Within two weeks of initiation of prednisone therapy, the patient was symptom-free. A repeat technetium polyphosphate bone scan revealed only a small residual area of mildly increased uptake over the upper thoracic vertebrae.

Dinerstein, S.L.; Kovarsky, J.

1984-08-01

26

Vertebral sarcoidosis: demonstration of bone involvement by computerized axial tomography  

International Nuclear Information System (INIS)

A report is given of a rare case of vertebral sarcoidosis with negative conventional spinal x-ray films, yet with typical cystic lesions of the spine found incidentally during abdominal computerized axial tomography (CAT). The patient was a 28-year-old black man, who was admitted for evaluation of a 1 1/2-year history of diffuse myalgias, intermittent fever to 102 F orally, bilateral hilar adenopathy, and leukopenia. A technetium polyphosphate bone scan revealed diffuse areas of increased uptake over the sternum, entire vertebral column, and pelvis. Conventional x-ray films of the cervical, thoracic, and lumbar spine, and an AP view of the pelvis were all normal. Chest x-ray film revealed only bilateral hilar adenopathy. During the course of an extensive negative evaluation for infection, an abdominal CAT scan was done, showing multiple, small, sclerotic-rimmed cysts at multiple levels of the lower thoracic and lumbar spine. Bone marrow biopsy revealed only changes consistent with anemia of chronic disease. Mediastinal lymph node biopsy revealed noncaseating granulomas. A tentative diagnosis of sarcoidosis was made, and treatment with prednisone, isoniazid and rifampin was begun. Within two weeks of initiation of prednisone therapy, the patient was symptom-free. A repeat technetium polyphosphate bone scan revealed only a small residual area of mildly increased uptake over the upper thoracic vertebrae

1984-01-01

27

Rim seal for turbine wheel  

Energy Technology Data Exchange (ETDEWEB)

A turbine wheel assembly includes a disk having a plurality of blades therearound. A ceramic ring is mounted to the housing of the turbine wheel assembly. A labyrinth rim seal mounted on the disk cooperates with the ceramic ring to seal the hot gases acting on the blades from the disk. The ceramic ring permits a tighter clearance between the labyrinth rim seal and the ceramic ring.

Glezer, Boris (Del Mar, CA); Boyd, Gary L. (Alpine, CA); Norton, Paul F. (San Diego, CA)

1996-01-01

28

Morphology of autogenous bone graft and castor oil polyurethane in the infraorbital rim of rabbits: a comparative study Estudo morfológico comparativo do enxerto ósseo autógeno e polímero de mamona em rebordo infra-orbitário de coelhos  

Digital Repository Infrastructure Vision for European Research (DRIVER)

PURPOSE: Morphological study comparing castor oil polyurethane and autogenous bone graft to repair bone defect in zygomatic bone of rabbits. METHODS: Twenty-four adult, male New Zealand rabbits were randomly distributed between two groups of twelve. Bone defects of 5mm in diameter were cut through the zygomatic bone and filled with polyurethane discs in the experimental group or autogenous bone harvested from the tibia in the control group. Animals were sacrificed after 30, 60 or 90 days, and...

2006-01-01

29

Benign fibrous histiocytoma of bone in a paediatric population: a report of 6 cases.  

Science.gov (United States)

Case records and radiological investigations of six children with benign fibrous histiocytoma were studied retrospectively. BFH occurred in the femur (n = 2), tibia (n = 2) and fibula (n = 2). Clinically, patients reported pain from the lesion lasting several months (mean 6 months). The pain was not associated with pathological fracture in any patient. On X-rays, the lesions appeared as lytic and sharply demarcated with a sclerotic rim and fine trabeculations. The reported cases were located in the metaphysis and the diaphysis of the long bones. The tumour was restricted to bone, without periosteal or soft tissue reaction. Treatment consisted of careful intralesional curettage of the lesion; the defect was thereafter filled with bone bank graft or injectable phosphocalcic cement. The length of follow-up ranged from 24 months to 4.75 years (mean 35.2 months). One case presented with recurrence of the disease and required successful repeat intralesional curettage. Benign fibrous histiocytoma is probably underestimated among patients less than 20 years of age. This diagnosis should be considered in any child or teenager who presents with a non-ossifying fibroma accompanied by unexplainable pain or a rapid growing. Surgery restricted to the osteolytic lesion seems sufficient to achieve bone healing. PMID:21409501

Ceroni, D; Dayer, R; De Coulon, G; Kaelin, A

2011-08-01

30

Surgical Management of Myxoma Like Sclerotic Calcified Mass in Left Ventricle Outflow Tract  

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Full Text Available In this short report, we present the succesfull surgical traetment of a patient who had an echocardiographic diagnosis of left ventricular mass during her routine controls. This patient was treated by surgical excision of the ventricular mass and after the pathological examination the diagnosis was “myxoma like sclerotic calcified mass”. The postoperative course was uneventful, and the patient was discharged on day 7 of surgery. The follow-up period lasted for 2 years without any event and the echocardiograms revelaed no residual or reccurrent lesions. Surgical resection of intracardiac masses are necessary and safe treatment options but there is not a standardization about the type of surgical options. The localization of the mass has the key role in determining the type of the surgical approach. In this case, aortotomy provided a good access and facilitated the exposure of this rare myxoma like sclerotic calcified mass.

Banu Bilezikçi

2011-04-01

31

Micromorphological and hardness analyses of human and bovine sclerotic dentin: a comparative study  

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The purpose of this study was to test the hypothesis that both human and bovine sclerotic dentin have similar hardness properties, in addition to similar micromorphological characteristics. Sixteen teeth (8 human and 8 bovine) exhibiting exposed dentin in the incisal edge and showing characteristics typical of sclerosis were used. Vickers surface microhardness testing was conducted. Three areas of the dentin surface of each specimen were selected. All teeth were processed for scanning electro...

Gisela Muassab Castanho; Márcia Martins Marques; Juliana Barbosa Marques; Maitê André Camargo; Antonio Alberto de Cara

2011-01-01

32

Negative bone scintigraphy and diffuse osteoblastic breast carcinoma metastases  

International Nuclear Information System (INIS)

The authors report a case of metastatic breast carcinoma with a negative bone scan in spite of densely sclerotic metastases on radiography. The literature is reviewed with regard to the subject of such negative bone scan in this clinical situation and the alternative possibilities to document the diagnostic of breast bone metastases are discussed. The 'normal' scintigraphic pattern is not clearly explained. (authors)

2001-03-01

33

Portable basketball rim testing device  

Energy Technology Data Exchange (ETDEWEB)

A portable basketball rim rebound testing device 10 is illustrated in two preferred embodiments for testing the rebound or energy absorption characteristics of a basketball rim 12 and its accompanying support to determine likely rebound or energy absorption charcteristics of the system. The apparatus 10 includes a depending frame 28 having a C-clamp 36 for releasably rigidly connecting the frame to the basketball rim 12. A glide weight 60 is mounted on a guide rod 52 permitting the weight 60 to be dropped against a calibrated spring 56 held on an abutment surface on the rod to generate for deflecting the basketball rim and then rebounding the weight upwardly. A photosensor 66 is mounted on the depending frame 28 to sense passage of reflective surfaces 75 on the weight to thereby obtain sufficient data to enable a processing means 26 to calculate the rebound velocity and relate it to an energy absorption percentage rate of the rim system 12. A readout is provided to display the energy absorption percentage.

Abbott, W. Bruce (610 Clover St., Cheney, WA 99004); Davis, Karl C. (Box 722, Richland, WA 99352)

1993-01-01

34

Effects of Altered Catecholamine Metabolism on Pigmentation and Physical Properties of Sclerotized Regions in the Silkworm Melanism Mutant  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Catecholamine metabolism plays an important role in the determination of insect body color and cuticle sclerotization. To date, limited research has focused on these processes in silkworm. In the current study, we analyzed the interactions between catecholamines and melanin genes and their effects on the pigmentation patterns and physical properties of sclerotized regions in silkworm, using the melanic mutant melanism (mln) silkworm strain as a model. Injection of ?-alanine into mln mutant s...

Qiao, Liang; Li, Yuanhao; Xiong, Gao; Liu, Xiaofan; He, Songzhen; Tong, Xiaoling; Wu, Songyuan; Hu, Hai; Wang, Rixin; Hu, Hongwei; Chen, Lushi; Zhang, Li; Wu, Jie; Dai, Fangyin; Lu, Cheng

2012-01-01

35

The lucent rim: a radiographic and computed tomography sign of Paget's disease of the skull  

Energy Technology Data Exchange (ETDEWEB)

In seven of eight patients with osteoporosis circumscripta of the cranial vault, the pagetic bone lacunae were separated from the normal bone by a lucent rim visible on conventional radiographs and computed tomography scans. The contour of the rim was sharp on the side of the healthy surrounding bone and hazy on the side of the defect. To our knowledge, this sign has been reported in one single previous article dealing with two pagetic patients with the bisphosphonate escape phenomenon. (orig.)

Brouard, R.; Wybier, M.; Laredo, J.-D. [Hopital universitaire Lariboisiere, Service de Radiologie osteo-articulaire, Paris (France); Miquel, A. [Hopital universitaire de bicetre, Service de Radiologie, Le kremlin bicetre (France)

2006-06-15

36

Singular structures on liquid rims  

Science.gov (United States)

This experimental note is concerned with a new effect we discovered in the course of studying water hammering phenomena. Namely, the ejecta originating from the solid plate impact on a water surface brings about a liquid rim at its edge with the fluid flowing towards the rim center and forming a singular structure resembling a "pancake." Here, we present the experimental observations and a qualitative physical explanation for the effect, which proves to be fundamental to the situation when the size and speed of the impacting body are such that the capillary effects become important.

Mayer, Hans C.; Krechetnikov, Rouslan

2014-03-01

37

Sub-super bone scan caused by bone marrow involvement of prostate cancer.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A 67-year-old man presented with malaise and marked anemia. A diagnostic workup revealed severe pancytopenia on a complete blood count and diffuse sclerotic change in the axial skeleton on a plain abdominal radiograph. Bone metastases being suspected from these findings, bone scintigraphy was performed. The bone scan demonstrated uniformly increased skeletal activity with faint soft-tissue activity. The findings of the bone scan, however, appeared atypical of the super scan caused by diffuse ...

1999-01-01

38

Linhas escleróticas metafisárias em crianças e adolescentes em uso de alendronato Sclerotic metaphyseal lines in children and adolescents treated with alendronate  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUÇÃO: Os bisfosfonatos inibem a reabsorção óssea pela interferência na ação dos osteoclastos. Dentre os efeitos adversos, as linhas escleróticas em metáfise de ossos longos são descritas como principal alteração radiográfica na faixa etária pediátrica. OBJETIVO: Avaliar a frequência de alterações radiográficas causadas pelo alendronato utilizado em crianças e adolescentes com baixa densidade óssea ou calcinose. PACIENTES E MÉTODOS: Foi realizado um estudo do tipo coorte retrospectiva analisando-se prontuários de 21 pacientes que fizeram uso de alendronato semanal por no mínimo 10 meses. Os pacientes realizaram radiografias de ossos longos antes do início do alendronato e aproximadamente um ano após o seu uso. RESULTADOS: Onze pacientes (52,3% apresentaram linhas escleróticas em metáfise dos ossos longos. A localização mais frequente foi em tíbia (8/11 pacientes, seguida de fêmur (7/11, úmero (6/11, rádio (4/11, ulna (3/11 e fíbula (2/11. Nenhum paciente apresentou regress??o das alterações radiográficas durante o tempo de evolução (até 1,1 ano após a suspensão do alendronato. CONCLUSÃO: Se usado com critério, o alendronato é seguro e as alterações radiográficas não mostraram ter um significado mais importante.INTRODUCTION: Bisphosphonates inhibit bone resorption by interfering with the action of osteoclasts. Among the adverse effects, sclerotic lines observed in the metaphysis of long bones have been described as the main imaging finding in pediatric patients. OBJECTIVE: To evaluate the frequency of radiographic changes caused by alendronate in children and adolescents with low bone density or calcinosis. PATIENTS AND METHODS: We conducted a cross-sectional study with 21 patients who were treated with once-weekly alendronate for at least 10 months. Patients underwent x-rays of long bones before the start of alendronate and approximately one year after its use. RESULTS: Eleven patients (52.3% had sclerotic lines in the metaphysis of long bones. The most frequent site was the tibia (8/11 patients, followed by the femur (7/11, humerus (6/11, radius (4/11, ulna (3/11, and fibula (2/11. Regression of radiographic changes during the study period (up to 1.1 years after discontinuation of alendronate was not observed. CONCLUSION: If used carefully, alendronate is safe and radiographic changes have not been shown to be clinically relevant.

Érika C.C. Silva

2010-06-01

39

Anterior glenoid rim fracture: the value of helical CT with threedimensional reconstruction and electronic humeral disarticulation  

Directory of Open Access Journals (Sweden)

Full Text Available Objectives: To show a new three-dimensional reconstructiontechnique based on helical computed tomography images withelectronic humeral disarticulation in anterior glenoid rim fractures,correlating the anatomic specimen with simulation of an anteriorglenoid rim fracture, as well as evaluating the extension of thefracture, the bone fragment position and distance in relation to theglenoid cavity in six patients. Methods: One scapula and onehumerus with no signs of fracture or congenital malformationswere placed in anatomical position using an adhesive tape aftersimulating an anterior glenoid rim fracture made by an osteotome.Helical CT imaging was acquired and three-dimensionalreconstructions were made based on these images, with andwithout electronic humeral disarticulation. The bone fragment waslocated, measured and its position in relation to the glenoid cavitywas assessed. Six patients with anterior glenoid rim fracture weresubmitted to CT of the shoulder using the same parameters asthose applied to the anatomic specimen. Results: In the anatomicspecimen and in all six patients the bone fragment was clearlydemonstrated; bone fragment measurements in the anatomicspecimen and in three-dimensional reconstructions wereequivalent. The fragment was better demonstrated in the imagestaken with electronic humeral disarticulation, particularly in thefrontal view of the glenoid cavity as observed in all six patients.Conclusion: We concluded that our experiment with the anatomicspecimen and the study of six patients allow us to state that thistechnique is safe and accurate to demonstrate the extension, sizeand location of the bone fragment in anterior glenoid rim fractures,and it provides essential elements for therapeutic planning.

Heverton César de Oliveira

2003-06-01

40

RIM  

REPORT OF THE MEETING On Monday morning, 19 November 2012, Ambassador Lazare Makayat Safousse, Republic ...SUSTAINABLE DEVELOPMENT AND PRIORITY AREAS FOR THE 2014/2015 WORK PROGRAMMEOn Tuesday morning, in a parallel plenary meeting chaired ...CLIMATE CHANGE AND DEVELOPMENT IN AFRICA: On Wednesday morning delegates were invited to consider a Report on Climate

 
 
 
 
41

Osteoblastic metastases from breast carcinoma with false-negative bone scan  

International Nuclear Information System (INIS)

The authors report a case of metastatic breast carcinoma that on investigation was shown to have a negative bone scan in spite of multiple densely sclerotic metastases on radiography and CT and a positive bone biopsy. The literature is reviewed with regard to the subject of negative bone scans in this situation. (orig.). With 3 figs

1997-07-07

42

Morphology of autogenous bone graft and castor oil polyurethane in the infraorbital rim of rabbits: a comparative study Estudo morfológico comparativo do enxerto ósseo autógeno e polímero de mamona em rebordo infra-orbitário de coelhos  

Directory of Open Access Journals (Sweden)

Full Text Available PURPOSE: Morphological study comparing castor oil polyurethane and autogenous bone graft to repair bone defect in zygomatic bone of rabbits. METHODS: Twenty-four adult, male New Zealand rabbits were randomly distributed between two groups of twelve. Bone defects of 5mm in diameter were cut through the zygomatic bone and filled with polyurethane discs in the experimental group or autogenous bone harvested from the tibia in the control group. Animals were sacrificed after 30, 60 or 90 days, and the zygomatic bones were macro- and microscopically analyzed. Student's, Fisher's, chi-squared and McNemar's tests were used for statistical analysis. RESULTS: Both the castor oil polyurethane and the autograft adapted well to the defect, with no need for fixation. Fibrous connective tissue encapsulated the polyurethane, but no inflammation or giant cell reaction was observed. Acidophilic and basophilic areas were observed inside the micropores of the polyurethane, suggesting cell nuclei. After 90 days, bone repair with a lamellar pattern of organization was observed in the control group. CONCLUSION: The castor oil polyurethane was biocompatible and did not cause inflammation. It may be considered an alternative to fill bone defects.OBJETIVO: Estudo morfológico comparativo do implante de poliuretana de mamona e enxerto ósseo autógeno em defeito ósseo padrão em osso zigomático de coelhos. MÉTODOS: Vinte e quatro coelhos Nova Zelândia, machos, adultos, foram distribuídos aleatoriamente em dois grupos de 12. Defeitos de 5mm de diâmetro, perenes, foram confeccionados em osso zigomático e preenchidos com discos pré-fabricados de poliuretana no grupo experimento ou osso autógeno extraído da tíbia no grupo controle. Os animais foram sacrificados após 30, 60 e 90 dias e as peças anatômicas foram avaliadas macro e microscopicamente. Foram utilizados os testes de Student, Fisher,qui-quadrado e McNemar para a análise estatística dos resultados. RESULTADOS: A poliuretana e o osso autógeno se adaptaram ao defeito sem necessidade de fixação. Houve formação de tecido conjuntivo fibroso envolvendo a poliuretana, sem reação inflamatória ou presença de células gigantes. Verificaram-se áreas acidófilas e basófilas nos poros do material implantado, sugestivas de núcleos celulares. No grupo controle, observou-se aos 90 dias o reparo ósseo de padrão lamelar clássico. CONCLUSÃO: A poliuretana de mamona foi biocompatível e não causou reação inflamatória deletéria. Pode ser uma alternativa para o preenchimento de defeitos ósseos.

José Carlos Garcia de Mendonça

2006-10-01

43

Morphology of autogenous bone graft and castor oil polyurethane in the infraorbital rim of rabbits: a comparative study / Estudo morfológico comparativo do enxerto ósseo autógeno e polímero de mamona em rebordo infra-orbitário de coelhos  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: Estudo morfológico comparativo do implante de poliuretana de mamona e enxerto ósseo autógeno em defeito ósseo padrão em osso zigomático de coelhos. MÉTODOS: Vinte e quatro coelhos Nova Zelândia, machos, adultos, foram distribuídos aleatoriamente em dois grupos de 12. Defeitos de 5mm de diâ [...] metro, perenes, foram confeccionados em osso zigomático e preenchidos com discos pré-fabricados de poliuretana no grupo experimento ou osso autógeno extraído da tíbia no grupo controle. Os animais foram sacrificados após 30, 60 e 90 dias e as peças anatômicas foram avaliadas macro e microscopicamente. Foram utilizados os testes de Student, Fisher,qui-quadrado e McNemar para a análise estatística dos resultados. RESULTADOS: A poliuretana e o osso autógeno se adaptaram ao defeito sem necessidade de fixação. Houve formação de tecido conjuntivo fibroso envolvendo a poliuretana, sem reação inflamatória ou presença de células gigantes. Verificaram-se áreas acidófilas e basófilas nos poros do material implantado, sugestivas de núcleos celulares. No grupo controle, observou-se aos 90 dias o reparo ósseo de padrão lamelar clássico. CONCLUSÃO: A poliuretana de mamona foi biocompatível e não causou reação inflamatória deletéria. Pode ser uma alternativa para o preenchimento de defeitos ósseos. Abstract in english PURPOSE: Morphological study comparing castor oil polyurethane and autogenous bone graft to repair bone defect in zygomatic bone of rabbits. METHODS: Twenty-four adult, male New Zealand rabbits were randomly distributed between two groups of twelve. Bone defects of 5mm in diameter were cut through t [...] he zygomatic bone and filled with polyurethane discs in the experimental group or autogenous bone harvested from the tibia in the control group. Animals were sacrificed after 30, 60 or 90 days, and the zygomatic bones were macro- and microscopically analyzed. Student's, Fisher's, chi-squared and McNemar's tests were used for statistical analysis. RESULTS: Both the castor oil polyurethane and the autograft adapted well to the defect, with no need for fixation. Fibrous connective tissue encapsulated the polyurethane, but no inflammation or giant cell reaction was observed. Acidophilic and basophilic areas were observed inside the micropores of the polyurethane, suggesting cell nuclei. After 90 days, bone repair with a lamellar pattern of organization was observed in the control group. CONCLUSION: The castor oil polyurethane was biocompatible and did not cause inflammation. It may be considered an alternative to fill bone defects.

José Carlos Garcia de, Mendonça; Rafael, De Rossi; Celso Massaschi, Inouye; Diego Rodrigo Paulillo, Bazan; João Carlos Castro, Monteiro; Juliana Pedroso de, Mendonça.

44

Partnerships in the Pacific Rim  

Energy Technology Data Exchange (ETDEWEB)

Due to the ever-increasing need to use global marketing as a means of gaining new business, Sargent and Lundy, like many of its competitors, has looked to stronger partnering relationships (e.g. alliances, teaming agreements, etc.) to enhance its ability to compete. New power generation plants, often developed, owned and operated by independent power companies in pacific Rim countries is one of the greatest sources of new business for engineering firms prepared to compete in this arena. In general, Sargent and Lundy focuses on three types of partnering relationships developed for international power markets in pacific Rim countries. These three relationships can be summarized as follows: partnering with other US-based organizations; partnering with non-US based organizations located in a country different than that of the intended market; and partnering with organizations located in the same country as the intended market. The features of each of the three partnering relationships discussed here involve considerable business development and logistics considerations and many other details that generally do not affect US-based partnering arrangements focusing on US business. The situation-specific details necessary to develop a successful partnering relationship depend greatly upon the client`s needs as well as the final goals of all companies involved.

Wendorf, A.W. [Sargent and Lundy, Chicago, IL (United States). Power Generation Services

1997-09-01

45

CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts: preliminary results  

International Nuclear Information System (INIS)

Objective: To evaluate CT-guided once-through bilateral percutaneous needle puncturing, aspiration and injection of sclerotic agents (ethanol) in treating bilateral multiple renal cysts. Methods: CT-guided once-through bilateral percutaneous needle puncturing sclerotic therapy was performed in 19 patients with bilateral multiple renal cysts. First, under CT guidance the puncture points and puncture routs were decided, then, puncturing, aspiration, rinsing and ethanol injection of the cysts were taken place by turn. The clinical results were analyzed. Results: bilateral percutaneous needle puncturing sclerotic therapy was successfully completed in all 19 cases. The whole procedure was well tolerated by all patients. The mean operative time was 23 minutes with a range of 20-35 minutes. No severe complications occurred. Conclusion: With proficient manipulation, CT-guided bilateral percutaneous needle puncturing sclerotic therapy for bilateral multiple renal cysts can be smoothly carried out. The technique can reduced the number of sclerotherapy times, cut down the medical expenses and, therefore, get twofold results with half the effort. (authors)

2011-06-01

46

Ewing's sarcoma of the tarsal bone  

Energy Technology Data Exchange (ETDEWEB)

The Ewing's sarcoma comprises approximately less than 10 percent of malignant bone tumors and 5 percent of all bone tumors, occurs in almost all bones of the body, and presents a widely divergent roentgenographic manifestations. The tarsal bones are involved only 2 percent in the Ewing's sarcoma. Two cases experienced by authors and ten cases published in literatures of Ewing's sarcoma of the tarsal bone were analyzed retrospectively. The result were as follows: 1. Of the tarsal bones, the calcaneus was 7 cases, the talus 4 cases, cuneiform 1 case. 2. Female was affected more commonly than male, the ratio being 4 to 1 in the tarsal bones. 3. About sixty percent of total cases in the tarsal bones had evidence of diffuse sclerotic pattern. All the cases of the talus had evidence of diffuse sclerotic pattern. 4. The diseases to be considered in differential diagnosis are as follows: avascular necrosis, tuberculous osteomyelitis, osteosarcoma, and pyogenic osteomyelitis. 5. The diffuse sclerosis radiographically showed a close relation with dead bone resulting from avascular necrosis due to tumor infiltration histologically. Periosteal reactive new bone and osteoid deposition on the dead bone were also correlated with diffuse sclerosis. 6. Because it is difficult to differentiate sclerotic lesions in the tarsal bones by radiographic methods alone, all such lesions should be subject to biopsy as early as possible.

Kwon, Jung Hyeok; Kim, Yong Sun; Kim, Tae Hun; Park, In Kyu; Kim, Yong Joo; Kang, Duk Sik; Sohn, Kyung Rak [College of Medicine, Kyungpook National University, Daegu (Korea, Republic of)

1985-06-15

47

High ionization efficiency techniques for CW RIMS  

Energy Technology Data Exchange (ETDEWEB)

The demand to measure high dynamic range isotope ratios on small samples with RIMS continues to increase. This paper discusses high ionization efficiency methods which can be applied to CW RIMS to potentially achieve several tens of percent ionization efficiencies for certain elements. The primary technique under development to achieve this is an external laser cavity which can generate very high circulating laser powers.

Fearey, B.L.; Johnson, S.G.; Miller, C.M.

1990-01-01

48

The detection of sclerotic changes of the coronaries and heart valves by scanning beams (ultrafast computed tomography using EVOLUTION)  

International Nuclear Information System (INIS)

With the advent of ultrafast computed tomography the range of diagnostic procedures for the quantitative determination of pathological changes in the coronary arteries has been broadened. The calcified coronary plaques found in this study, which in some of the patients were markedly pronounced, gave no immediate clue as to what extent sclerotic changes had already occurred in the coronaries examined. Nor was it possible on the basis of this method to pinpoint the vascular sections showing calcified plaques in patients undergoing maintenance dialysis. It may, however, permit careful predictions to be made for patients at a high risk of developing coronary artery disease. Sclerotic changes of the heart values occur with above-average frequency in dialysis patients and may be assessed quantitatively by the method described. The results described show that findings revealed by scanning electron beams may provide indirect information on metabolic processes in patients suffering from chronic ailments. (orig./MG)

1994-02-01

49

High-precision thorium RIMS for geochemistry  

Energy Technology Data Exchange (ETDEWEB)

We present our latest results in the development of resonance ionization mass spectrometry (RIMS) using cw lasers to measure isotope ratios of importance in geochemistry and geochronology. The RIMS method provides a higher ionization efficiency than thermal ionization allowing analysis of smaller sample sizes, while maintaining equivalent internal precision. The bias introduced in {sup 230/232}Th ratio measurements by the RIMS method when using narrow-band and broad-band lasers is discussed. Spectra of {sup 239}Th, which can be used as an internal standard, are also presented.

Fearey, B.L.; Tissue, B.M.; Olivares, J.A.; Loge, G.W.; Murrell, M.T.; Miller, C.M.

1992-01-01

50

High-precision thorium RIMS for geochemistry  

Energy Technology Data Exchange (ETDEWEB)

We present our latest results in the development of resonance ionization mass spectrometry (RIMS) using cw lasers to measure isotope ratios of importance in geochemistry and geochronology. The RIMS method provides a higher ionization efficiency than thermal ionization allowing analysis of smaller sample sizes, while maintaining equivalent internal precision. The bias introduced in {sup 230/232}Th ratio measurements by the RIMS method when using narrow-band and broad-band lasers is discussed. Spectra of {sup 239}Th, which can be used as an internal standard, are also presented.

Fearey, B.L.; Tissue, B.M.; Olivares, J.A.; Loge, G.W.; Murrell, M.T.; Miller, C.M.

1992-08-01

51

The effects of hydroxyapatite coating and bone allograft on fixation of loaded experimental primary and revision implants  

DEFF Research Database (Denmark)

We used our established experimental model of revision joint replacement to examine the roles of hydroxyapatite coating and bone graft in improving the fixation of revision implants. The revision protocol uses the Søballe micromotion device in a preliminary 8-week period of implant instability for the presence of particulate polyethylene. During this procedure, a sclerotic endosteal bone rim forms, and a dense fibrous membrane is engendered, having macrophages with ingested polyethylene and high levels of inflammatory cytokines. At the time of revision after 8 weeks, the cavity is revised with either a titanium alloy (Ti) or a hydroxyapatite (HA) 6.0 mm plasma-sprayed implant, in the presence or absence of allograft packed into the initial 0.75 mm peri-implant gap. The contralateral limb is subjected to primary surgery with the same implant configuration, and serves as control. 8 implants were included in each of the 8 treatment groups (total 64 implants in 32 dogs). The observation period was 4 weeks after revision. Outcome measures are based on histomorphometry and mechanical pushout properties. The revision setting was always inferior to its primary counterpart. Bone graft improved the revision fixation in all treatment groups, as also did the HA coating. The sole exception was revision-grafted HA implants, which reached the same fixation as primary Ti and HA grafted implants. The revision, which was less active in general, seems to need the dual stimulation of bone graft and HA implant surface, to obtain the same level of fixation associated with primary implants. Our findings suggest that the combination of HA implant and bone graft may be of benefit in the clinical revision implant setting.

Søballe, Kjeld; Mouzin, Olivier R G

2003-01-01

52

The Pacific Rim Library: A Surprising Pearl  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Pacific Rim Library (PRL) is an initiative of the Pacific Rim Digital Library Association (PRDLA). The project began in 2006 using the OAI-PMH paradigm and now holds over 300,000 records harvested from OAI data provider libraries around the Pacific. PRL's goal is to enable the sharing of digital collections amongst PRDLA members and the world, but greater unexpected benefits have been discovered. Through mirroring their metadata, PRL increases the chance that their data will be discovered...

Palmer, Dt

2009-01-01

53

Association between the proportion of globally sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy patients  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Immunoglobulin A nephropathy is the most common form of glomerular nephropathy among children and young adults.Objectives: To evaluate the possible correlation between the extent of sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy (IgAN patients, we conducted an observational study, on 136 IgAN patients’ biopsies.Patients and Methods: Of the 136 patients, 94 (69.1% were male. The mean age of the patients was 37.6 ± 13.4 years. The mean of serum creatinine was 1.94±3.7 mg/dl (median=1.2mg/dl, also mean of proteinuria was 1726±1247 mg/day (median=1500 mg/day. In this study of 14.9±3.7 glomeruli in biopsies, 2.5±3.2 (median=2 were globally sclerotic.Results: In this study we found, significant positive correlation between proportion of globally sclerotic glomeruli and serum creatinine, amount of proteinuria, and also quantity of tubulointerstitial fibrosis. Also, in this study, the association of proportion of globally sclerotic glomeruli with M, E, S and T variables of Oxford classification was significantly positive.Conclusion: We propose firstly that, sclerotic glomeruli reported routinely in the pathology reports of IgA nephropathy patients and secondly we suggest further investigations to possible inclusion of other morphologic variables like proportion of sclerotic glomeruli to Oxford classification of IgAN to widen the scope of this classification.

Nasri Hamid

2012-12-01

54

Rimmed and edge thickened Stodola shaped flywheel  

Science.gov (United States)

A flywheel (10) is described that is useful for energy storage in a hybrid vehicle automotive power system or in some stationary applications. The flywheel (10) has a body (15) composed of essentially planar isotropic high strength material. The flywheel (10) body (15) is enclosed by a rim (50) of circumferentially wound fiber (2) embedded in resin (3). The rim (50) promotes flywheel (10) safety and survivability. The flywheel (10) has a truncated and edge thickened Stodola shape designed to optimize system mass and energy storage capability.

Kulkarni, Satish V. (San Ramon, CA); Stone, Richard G. (Oakland, CA)

1983-01-01

55

Imaging appearance of bone tumors of the maxillofacial region  

Directory of Open Access Journals (Sweden)

Full Text Available This paper reviews the imaging appearance of benign and malignant bone tumors of the maxillofacial region. A benign bone tumor commonly appears as a well circumscribed lesion. The matrix of the tumor may be calcified or sclerotic. Malignancies often display aggressive characteristics such as cortical breakthrough, bone destruction, a permeative pattern and associated soft-tissue masses. Computed tomography scan is an excellent imaging modality for accurate localization of the lesion, characterization of the tumor matrix and detection of associated osseous changes such as bone remodeling, destruction or periosteal reaction. Magnetic resonance imaging is of limited value in the evaluation of maxillofacial bone tumors.

Ahmed Abdel Khalek Abdel Razek

2011-01-01

56

Ossicular bone modeling in acute otitis media  

DEFF Research Database (Denmark)

A number of middle ear diseases are associated with pathologic bone modeling, either formative or resorptive. As such, the pathogenesis of a sclerotic mastoid has been controversial for decades. Experimental studies on acute middle ear infection have shown progressive osteoneogenesis in the bone structures surrounding the middle ear cavity, and a few studies have reported acute changes of the ossicular chain. However, detailed qualitative and quantitative information on ossicular bone modeling dynamics has not been accounted for and is thus the purpose of this study.

Salomonsen, Rasmus Lysholdt; Hermansson, Ann

2010-01-01

57

Echogenic rim of hepatic hemangioma on abdominal ultrasound  

Energy Technology Data Exchange (ETDEWEB)

To investigate the association between the size of the hepatic hemangioma and the shape and thickness of the echogenic rim of hepatic hemangioma on abdominal ultrasound. We examined 47 cases (M:F=24:23, mean age 47.1) of hepatic hemangiomas with echogenic rim on abdominal ultrasound during the past 2 years. Radiologic findings were retrospectively reviewed in terms of completeness and thickness of echogenic rim. If echogenic rim showed even thickness, it was measured. But if not, the maximum and minimum thickness of the rim was measured. The association between the size of hemangioma and the completeness and thickness of the echogenic rim were analyzed statistically. Of the 47 cases, complete echogenic rim and incomplete echogenic rim were obtained in 29 (62%) and 18 (38%) cases, respectively. Twenty-two cases of hemangioma were less than 2 cm in diameter, and their distribution according to echogenic rim were as follows: complete echogenic rim (17/20, 91% mean thickness 2.2 cm) and uneven thickness with complete echogenic rim (3/20, 15%, range:2.0-6.1 mm). Twenty-five hemangiomas were larger than 2 cm in diameter and their distribution according to echogenic rim were as follows: complete echogenic rim (n=9, 34%), incomplete echogenic rim (n=16, 64%0,even thickness with complete echogenic rim (3/9, 33%, mean thickness 2.2 mm) and uneven thickness with complete echogenic rim (6/9,67%, range: 2.0-7.6 mm). In statistical analysis, hemangiomas more than 2 cm in diameter were more likely to have incomplete echogenic rim (p<0.05) than those of less than 2 cm; hemangiomas more than with more than 2 cm in diameter and complete echogenic rim showed uneven thickness of echogenic rim (p<0.05), more often than those of less than 2 cm diameter. Hemangiomas with more than 2 cm in diameter showed more frequent incomplete echogenic rim than those of less than 2 cm in diameter, which had more frequent complete echogenic rim. Hemangiomas with complete echogenic rim and even rim thickness were more prevalent in those with less than 2 cm in diameter. Uneven rim thickness was present more often in those with more than 2 cm in diameter.

Park, Sang Woo; Kang, Chang Ho; Kim, Jin Hyoung; Kim, Chul Joong; Cheong, In Joo; Kim, Baek Hyun; Cha, Sang Hoon; Park, Cheol Min; Chung, Kyu Byung [Korea University College of Medicine, Seoul (Korea, Republic of)

2000-03-15

58

Reaction kinetics of dolomite rim growth  

Science.gov (United States)

Reaction rims of dolomite (CaMg[CO3]2) were produced by solid-state reactions at the contacts of oriented calcite (CaCO3) and magnesite (MgCO3) single crystals at 400 MPa pressure, 750-850 °C temperature, and 3-146 h annealing time to determine the reaction kinetics. The dolomite reaction rims show two different microstructural domains. Elongated palisades of dolomite grew perpendicular into the MgCO3 interface with length ranging from about 6 to 41 µm. At the same time, a 5-71 µm wide rim of equiaxed granular dolomite grew at the contact with CaCO3. Platinum markers showed that the original interface is located at the boundary between the granular and palisade-forming dolomite. In addition to dolomite, a 12-80 µm thick magnesio-calcite layer formed between the dolomite reaction rims and the calcite single crystals. All reaction products show at least an axiotactic crystallographic relationship with respect to calcite reactant, while full topotaxy to calcite prevails within the granular dolomite and magnesio-calcite. Dolomite grains frequently exhibit growth twins characterized by a rotation of 180° around one of the equivalent axis. From mass balance considerations, it is inferred that the reaction rim of dolomite grew by counter diffusion of MgO and CaO. Assuming an Arrhenius-type temperature dependence, activation energies for diffusion of CaO and MgO are E a (CaO) = 192 ± 54 kJ/mol and E a (MgO) = 198 ± 44 kJ/mol, respectively.

Helpa, V.; Rybacki, E.; Abart, R.; Morales, L. F. G.; Rhede, D.; Je?ábek, P.; Dresen, G.

2014-04-01

59

Treatment of scaphoid nonunion with vascularised and nonvascularised dorsal bone grafting from the distal radius  

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We conducted a prospective randomised study comparing the clinical, functional and radiographic results of 46 patients treated for scaphoid nonunion using a vascularised bone graft from the dorsal and distal aspect of the radius (group I), relative to 40 patients treated by means of a conventional non-vascularised bone graft from the distal radius (group II). Surgical findings included 30 sclerotic, poorly-vascularised scaphoids in group I versus 20 in group II. Bone fusion was achieved in 89...

Ribak, Samuel; Medina, Carlos Eduardo Gonzalez; Mattar, Rames; Ulson, Heitor Jose Rizzardo; Resende, Marcelo Rosa; Etchebehere, Mauricio

2010-01-01

60

CT diagnosis of sacral bone tumors  

International Nuclear Information System (INIS)

Objective: To evaluate the CT characteristics of sacral bone tumors. Methods: The CT characteristics of 28 cases with sacral bone tumors were retrospectively analyzed, including 13 cases metastasizes, 4 cases chordomas, 1 case chondrosarcoma, 1 case primitive neurotodemal tumors (PNET), 3 cases osteoblastomas, 1 case osteosarcoma, 2 cases neurilemmomas, 3 cases cysts (1 case of simple bone cyst and 2 cases of intracranial arachnoid cysts). Results: The CT characteristics of sacral bone tumors were as followings: different ranges and location of tumor, sacral bone destruction (lytic destruction for most malignant tumors and expansive for benign tumors), the remains of bone, soft tissue mass, calcification in tumor, sacral canal and sacral foramen obstruction. Benign tumors were often with sharp margin and sclerotic borders (except osteoblastomas), and the malignant tumors were often without clear verge and sclerotic borders. Except the cystic diseases, all the others were enhanced variously after contrast enhanced scanning. Conclusion: CT imaging can clearly display the location, ranges of tumor and the relation between tumor and surrounding tissues. Most sacral bone tumors can be correctly diagnosed in pre-operation according to their different CT characteristics. (authors)

2008-08-01

 
 
 
 
61

West Rim of Endeavour and a Farther Crater's Rim on Horizon  

Science.gov (United States)

[figure removed for brevity, see original site] In the left half of this view from the panoramic camera (Pancam) of NASA's Mars Exploration Rover Opportunity, a western portion of the rim of Endeavour Crater is visible on the horizon. In the right half, the rim of a smaller crater, farther away, appears faintly on the horizon. Opportunity's Pancam took this image on March 8, 2009, during the 1,821st Martian day, or sol, of the rover's mission on Mars. The width of the image covers approximately one degree of the horizon. The part of Endeavour's rim visible here is about 16 kilometers (10 miles) from where Opportunity was when the image was taken. The rover was at the same location as when its Pancam took images after a drive on Sol 1820. Opportunity remained at that location until a drive on Sol 1823. The more-distant rim to the right, part of Iazu Crater, is about 38 kilometers (24 miles) away. Iazu is south of Endeavour and about 7 kilometers (4 miles) in diameter.

2009-01-01

62

Rim intratorácico ectópico / Thoracic ectopic kidney  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O rim ectópico intratorácico é uma anomalia rara. De todas as ectopias renais é a mais rara (p = 0,005%). Relata-se um caso de ectopia renal intratorácica em um homem negro de 83 anos, que procurou atendimento médico com quadro clínico compatível com enfisema pulmonar. Foi solicitado radiograma de t [...] órax, que evidenciou uma massa, diagnosticada por tomografia computadorizada como ectopia renal. A maioria dos casos de rim torácico aparece como uma tumoração intratorácica encontrada em radiogramas de tórax solicitados por qualquer outra razão alheia à suspeita dessa anomalia, e não necessita de tratamento específico. Abstract in english Thoracic ectopic kidney is a rare anomaly, the rarest of all renal ectopia types (p = 0.005%). Herein, we describe a case of thoracic ectopic kidney in an 83-year-old black man who, upon seeking medical attention, presented a clinical profile consistent with pulmonary emphysema. A chest X-ray was or [...] dered, and the results showed evidence of a mass, which was then diagnosed (through computed tomography) as renal ectopia. The majority of thoracic ectopic kidney cases present as an intrathoracic tumor seen on chest X-rays ordered for reasons other than suspicion of this anomaly and do not require special treatment.

Claudinei Leôncio, Beraldo; Eugênio Fernandes de, Magalhães; Demétrius Tierno, Martins; Douglas Silva, Coutinho; Lívia Silva, Tiburzio; Mário, Ribeiro Neto.

63

Multiple fluid-filled bone metastases.  

Science.gov (United States)

Bone metastases are usually seen on imaging studies as lytic lesions and less often as sclerotic or mixed lesions. We report an exceedingly unusual case of breast cancer identified after magnetic resonance imaging showed bone metastases with fluid-fluid levels in the spine and sacrum. Bone images containing fluid-fluid levels are usually solitary abnormalities produced by aneurismal bone cysts. The fluid-fluid level is due to bleeding within the tumor followed by layering of the blood components based on density differences. Only two other cases of bone metastases with multiple fluid-fluid levels have been reported. Although fluid-fluid levels are exceedingly rare, clinicians should be aware that they might indicate a malignancy, particularly when they are multiple. PMID:20194045

Frenzel, Laurent; Javier, Rose-Marie; Eichler, Francoise; Zollner, Goerg; Sibilia, Jean

2010-03-01

64

Aquaporin-4 expression in distal myopathy with rimmed vacuoles  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles. To date, the role of aquaporin-4 water channel in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy has not been studied. Case presentation Here, we studied the expression of aquaporin-...

2012-01-01

65

Measurement of wheel rim wear on railway wheels using radioisotopes  

International Nuclear Information System (INIS)

A radioisotopic measuring method developed for studying the wear process of wheel rims of railway vehicles is described. The wear process may be monitored by the measurement of activity of a thin galvanic layer deposited onto the rim and labelled by iron 59. The high sensitivity of the method allows the determination of the wear rate distribution even within a few days. The results of measurements on three different rim profiles are analysed. (R.J.)

1979-01-01

66

Aquaporin-4 expression in distal myopathy with rimmed vacuoles  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles. To date, the role of aquaporin-4 water channel in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy has not been studied. Case presentation Here, we studied the expression of aquaporin-4 in muscle fibers of a patient with distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy. Immunohistochemical and immunofluorescence analyses showed that sarcolemmal aquaporin-4 immunoreactivity was reduced in many muscle fibers of the patient. However, the intensity of aquaporin-4 staining was markedly increased at rimmed vacuoles or its surrounding areas and in some muscle fibers. The fast-twitch type 2 fibers were predominantly involved with the strong aquaporin-4-positive rimmed vacuoles and TAR-DNA-binding protein-43 aggregations. Rimmed vacuoles with strong aquaporin-4 expression seen in the distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy patient were not found in control muscles without evidence of neuromuscular disorders and the other disease-controls. Conclusions Aquaporin-4 might be crucial in determining the survival or degeneration of fast-twitch type 2 fibers in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy.

Hoshi Akihiko

2012-04-01

67

Alteration and Formation of Rims on the CM Parent Body.  

Science.gov (United States)

All types of coarse-grained components in CM chondrites are surrounded by fine-grained dust coatings, but the origin of these rims is not yet clear. Although a strictly nebular origin seems likely for rims in the relatively unaltered type 3 chondrites, th...

L. B. Browning H. Y. Mcsween M. Zolensky

1994-01-01

68

The multiple faces of valosin-containing protein-associated diseases: inclusion body myopathy with Paget's disease of bone, frontotemporal dementia, and amyotrophic lateral sclerosis.  

Science.gov (United States)

Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD) is a progressive, fatal genetic disorder with variable penetrance, predominantly affecting three main tissue types: muscle (IBM), bone (PDB), and brain (FTD). IBMPFD is caused by mutations in the ubiquitously expressed valosin-containing protein (VCP) gene, a member of the AAA-ATPase superfamily. The majority of individuals who develop IBM have progressive proximal muscle weakness. Muscle biopsies reveal rimmed vacuoles and inclusions that are ubiquitin- and TAR DNA binding protein-43 (TDP-43)-positive using immunohistochemistry. PDB, seen in half the individuals, is caused by overactive osteoclasts and is associated clinically with pain, elevated serum alkaline phosphatase, and X-ray findings of coarse trabeculation and sclerotic lesions. FTD diagnosed at a mean age of 55 years in a third of individuals is characterized clinically by comprehension deficits, dysnomia, dyscalculia, and social unawareness. Ubiquitin- and TDP-43-positive neuronal inclusions are also found in the brain. Genotype-phenotype correlations are difficult with marked intra-familial and inter-familial variations being seen. Varied phenotypes within families include frontotemporal dementia, amyotrophic lateral sclerosis, Parkinsonism, myotonia, cataracts, and anal incompetence, among others. Cellular and animal models indicate pathogenetic disturbances in IBMPFD tissues including altered protein degradation, autophagy pathway alterations, apoptosis, and mitochondrial dysfunction. Currently, mouse and drosophila models carrying VCP mutations provide insights into the human IBMPFD pathology and are useful as tools for preclinical studies and testing of therapeutic strategies. In this review, we will explore the pathogenesis and clinical phenotype of IBMPFD caused by VCP mutations. PMID:21892620

Nalbandian, Angèle; Donkervoort, Sandra; Dec, Eric; Badadani, Mallikarjun; Katheria, Veeral; Rana, Prachi; Nguyen, Christopher; Mukherjee, Jogeshwar; Caiozzo, Vincent; Martin, Barbara; Watts, Giles D; Vesa, Jouni; Smith, Charles; Kimonis, Virginia E

2011-11-01

69

Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS) and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etc [...] h GO (SDI), the 2-step self-etch Adper SE Bond (3MESPE) and the 35% phosphoric acid (3MESPE) from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE) were applied on the bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm 2 ) and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material) was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment), according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05). Results: The duplication of the conditioning time favored only the GO adhesive (p

Alexandra Patricia, Mena-Serrano; Eugenio Jose, Garcia; Miguel Muñoz, Perez; Gislaine Cristine, Martins; Rosa Helena Miranda, Grande; Alessandro Dourado, Loguercio; Alessandra, Reis.

70

Effect of the application time of phosphoric acid and self-etch adhesive systems to sclerotic dentin  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To evaluate the effect of application time on the resin-dentin bond strength (µTBS and etching pattern of adhesive systems applied on sclerotic dentine. Material and Methods: A total of forty-two bovine incisors had their roots removed. The 1-step self-etch GO (SDI, the 2-step self-etch Adper SE Bond (3MESPE and the 35% phosphoric acid (3MESPE from the 2-step etch-and-rinse Adper Single Bond 2 (3MESPE were applied on the bovine incisal surfaces according to the manufacturer's instructions or duplicating the recommended conditioning time. After adhesive application, thirty teeth were restored with composite resin, stored for 24 h in distilled water at 37°C, and sectioned into resin-dentin bonded sticks (0.8 mm 2 and tested according to the µTBS at 0.5 mm/min. The etching pattern of the remaining twelve teeth (n=4 for each material was examined under scanning electron microscopy. Each tooth was divided into a buccal-to-lingual direction into three thirds, and each third randomly assigned to the groups: control (no treatment, according to the manufacturers' instructions and duplicating the recommended application time. The µTBS and the relative percentage of the tubule area opening were evaluated by two-way repeated measures ANOVA and Tukey's tests (?=0.05. Results: The duplication of the conditioning time favored only the GO adhesive (p<0.05. Both application methods significantly increased the tubule area opening (p<0.05 compared to the controls. Conclusions: The efficacy of duplicating the conditioning time was only effective for the 1-step self-etch adhesive system tested.

Alexandra Patricia Mena-Serrano

2013-04-01

71

Cholescintigraphic findings of acute cholecystitis emphasized on the rim sign  

Energy Technology Data Exchange (ETDEWEB)

Nonvisualization of gallbladder in cholescintigraphy has been established to be a major and reliable finding for acute cholecystitis. A rim of increased pericholecystic hepatic activity (PCHA or Rim sign) in conjunction with gallbladder nonvisualization was reported to be secondary sign of acute cholecystitis. To determine the frequency and significance of the pericholecystic hepatic activity, we evaluated 217 cholescintigram in patients clinically suspected of acute cholecystitis. After brief review of cholescintigraphic findings of acute cholecystitis, the significance of the Rim sign is described. 1) The frequency of the Rim sign in surgically proved acute cholecystitis was 14.9%. 2) The frequency of Rim sign in complicated acute cholecystitis including gallbladder empyema and/or pericholecystic abscess (7/22) and in noncomplicated acute cholecystitis (3/45) was 31.8%, 6.6% respectively. The present study suggests that the Rim sign appear to indicate relatively high incidence of complicated acute cholecystitis and effort should be made observing the presence of the Rim sign in cholescintigraphy.

Lim, Se Hwan; Kim, Chahng Guhn; Kim, Byung Chan; Won, Jong Jin; Chae, Kwon Mook [Wonkwang University School of Medicine, Iksan (Korea, Republic of)

1988-12-15

72

Learning from California and the Pacific Rim  

International Nuclear Information System (INIS)

Heavy oils are found in 10 of the 14 largest oilfields in Alaska and California. In the US west coast region, petroleum demand is dominated by light transport fuels, and there is a lack of a discrete and conspicuous heavy oil market. The structure and behavior of west coast petroleum markets, and their interactions with crude-oil and petroleum product markets elsewhere on the Pacific Rim are discussed with regard to how the market for growing volumes of western Canadian heavy oils might evolve. An analysis of crude oil prices versus API gravity demonstrates the price penalties on oil of low gravity, high sulfur, and high transport cost. Prices at the high gravity end tend to correlate closely with Asian light crude and unfinished gasoline prices. The heaviest crudes are priced in competition with other chemically similar residual oils for direct fuel use, blending, or refinery feedstock. The biggest component of the west coast heavy oil market is bunker fuel. The market value of heavy crudes in the west coast is thus determined by regional supply and demand for heavy hydrocarbon molecules, whatever the source. The west coast is not a promising market for Canadian heavy crudes, and exports to Asia would have to compete both with residual oils from Asia and the US west coast and with California heavy crudes. US west coast production peaked in 1989 and regional production can be expected to decline further in average gravity. New production from known but undeveloped heavy oil pools near Prudhoe Bay or in the California offshore could be expected to postpone the need for imports to the west coast and to depress prices. A removal of the Alaska crude oil export ban could improve the west coast heavy oil market. 5 refs., 2 figs., 1 tab

1993-12-02

73

Rimmed and edge thickened stodola shaped flywheel. [Patent application  

Science.gov (United States)

A flywheel is described that is useful for energy storage in a hybrid vehicle automotive power system or in some stationary applications. The flywheel has a body composed of essentially planar isotropic high strength material. The flywheel body is enclosed by a rim of circumferentially wound fiber embedded in resin. The rim promotes flywheel safety and survivability. The flywheel has a truncated and edge thickened Stodola shape designed to optimize system mass and energy storage capability.

Kulkarni, S.V.; Stone, R.G.

1980-09-24

74

Rim region growth and its composition in reaction bonded boron carbide composites with core-rim structure  

International Nuclear Information System (INIS)

Aluminum was detected in reaction-bonded boron carbide that had been prepared by pressureless infiltration of boron carbide preforms with molten silicon in a graphite furnace under vacuum. The presence of Al2O3 in the heated zone, even though not in contact with the boron carbide preform, stands behind the presence of aluminium in the rim region that interconnects the initial boron carbide particles. The composition of the rim corresponds to the Bx(C,Si,Al)y quaternary carbide phase. The reaction of alumina with graphite and the formation of a gaseous aluminum suboxide (Al2O) accounts for the transfer of aluminum in the melt and, subsequently in the rim regions. The presence of Al increases the solubility of boron in liquid silicon, but with increasing aluminum content the activity of boron decreases. These features dominate the structural evolution of the rim-core in the presence of aluminum in the melt.

2009-06-01

75

Heterotopic bone formation following hip arthroplasty in Paget's disease.  

Science.gov (United States)

Heterotopic bone formation in soft tissues occurs commonly in Paget's disease patients following a primary total hip arthroplasty (THA). The nature of this heterotopic bone has not been documented. In this report, we show that the heterotopic bone removed 14 years after primary THA in a case of Paget's disease was sclerotic, contained prominent mosaic cement lines and showed increased remodelling activity on the bone surface. In addition to these typically Pagetic histological features, it was noted ultrastructurally that the osteoclasts contained characteristic intranuclear viral-like inclusions. In contrast, the foreign body macrophages found in the joint pseudocapsule and pseudomembrane, which are a population of mononuclear precursor cells from which osteoclasts can be formed, did not contain viral-like inclusions. These findings are of interest regarding the pathogenesis of heterotopic bone formation following hip arthroplasty and the ontogeny of Pagetic osteoclasts. PMID:15260016

Ferguson, D J P; Itonaga, I; Maki, M; McNally, E; Gundle, R; Athanasou, N A

2004-06-01

76

Why do complex impact craters have elevated crater rims?  

Science.gov (United States)

Most of the complex impact craters on the Moon and on Mars have elevated crater rims like their simple counterparts. The raised rim of simple craters is the result of (i) the deposition of a coherent proximal ejecta blanket at the edge of the transient cavity (overturned flap) and (ii) a structural uplift of the pre-impact surface near the transient cavity rim during the excavation stage of cratering [1]. The latter occurs either by plastic thickening or localized buckling of target rocks, as well as by the emplacement of interthrust wedges [2] or by the injection of dike material. Ejecta and the structural uplift contribute equally to the total elevation of simple crater rims. The cause of elevated crater rims of large complex craters [3] is less obvious, but still, the rim height scales with the final crater diameter. Depending on crater size, gravity, and target rheology, the final crater rim of complex craters can be situated up to 1.5-2.0 transient crater radii distance from the crater center. Here the thickness of the ejecta blanket is only a fraction of that occurring at the rim of simple craters, e.g. [4], and thus cannot account for a strong elevation. Likewise, plastic thickening including dike injection of the underlying target may not play a significant role at this distance any more. We started to systematically investigate the structural uplift and ejecta thickness along the rim of complex impact craters to understand the cause of their elevation. Our studies of two lunar craters (Bessel, 16 km diameter and Euler, 28 km diameter) [5] and one unnamed complex martian crater (16 km diameter) [6] showed that the structural uplift at the final crater rim makes 56-67% of the total rim elevation while the ejecta thickness contributes 33-44%. Thus with increasing distance from the transient cavity rim, the structural uplift seems to dominate. As dike injection and plastic thickening are unlikely at such a distance from the transient cavity, we propose that reverse faulting induced by radially outward directed maximum stresses during the excavation flow may be responsible for the elevation of complex crater rims. This hypothesis is tested at terrestrial craters whose apparent crater rims are often confined by circumferential faults [7]. References:[1] Shoemaker, E. M. (1963) The Solar System, 4, 301-336. [2] Poelchau M.H. et al. (2009), JGR, 114, E01006. [3] Settle, M., and Head, J.W., (1977), Icarus, 31, 123. [4] McGetchin, T. R., et al., (1973), EPSL, 20, 226.[5] Krüger T. et al. (2014), LPSC 45, #1834. [6] Sturm, S. et al. (2014), LPSC 45, 1801. [7] Turtle, E. et al. (2005), GSA-SP. 384, 1.

Kenkmann, Thomas; Sturm, Sebastian; Krueger, Tim

2014-05-01

77

Influence of RIM effect on fuel centre temperature  

International Nuclear Information System (INIS)

In recent years the RIM effect in the high burnup region has been discussed in many papers. The RIM effect is characterized by higher burnup, subdivision of grains, and formation of fine pores (porosity increase) at the pellet periphery. In this paper we report the analysis results of the increase of pellet centre temperature by the RIM effect. The pellet centre temperature was calculated using a radial power distribution and the pellet thermal conductivity as a function of the pellet porosity and burnup. The radial porosity distribution was evaluated from SEM images of BWR fuel pellets irradiated up to about 60 GW·d/t. The influence of porosity of pellet thermal conductivity was evaluated by FEM analysis. The thermal conductivity was derived from the measured thermal diffusivity data in a previous report. In the peripheral region of a pellet irradiated to 60 GW·d/t, the maximum porosity was about 15-20%. The correction function for the influence of porosity on pellet thermal conductivity was derived from the results of FEM analysis. The analysis conditions were that the pellet burnup was 60 GW·d/t, the pellet surface temperature was 400 deg. C, and the linear heat generation rate was 300 W/cm. The analysis revealed that the influence of the RIM effect on fuel centre temperature is small, that is to say, about 20 deg. C for the above conditions. In addition, the results of pellet centre temperature analysis showed that the RIM effect influence on pellet temperature was not significant up to 75 GW·d/t. However, the influence of the RIM effect cannot be ignored in the ultra high burnup region close to 100 GW·d/t. Thus, it is necessary that more data for RIM growth in the ultra high burnup region will be collected to evaluate fuel performance more accurately. (author)

2000-10-01

78

Regeneration of Mastoid Air Cells in Vivo Using Autologous Cortical Bone  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Purpose: This was a preliminary study to assess surgical construction and regeneration of mastoid air cells in the treatment of cholesteatoma. Methods: Two-stage tympanoplasty with mastoidectomy was performed in four cases of unilateral cholesteatoma with sclerotic mastoid. During the first-stage operation, small fragments of autologous cortical bone were inserted into the cavity after mastoidectomy to form a honeycomb-like structure. Reconstruction of the lateral wall of the mastoid cavity w...

Ken-ichi Kaneko; Shin-ichi Kanemaru; Rie Kanai; Yamada Atsushi

2012-01-01

79

Bone scintigraphy, radiography and MRI in the diagnosis and evaluation of treatment response of calcaneal tuberculosis  

International Nuclear Information System (INIS)

Aim: We describe the role of various imaging modalities in the diagnosis and follow up of calcaneal tuberculosis. Materials and methods: Six patients (5 males, 1 female; age range 16-49 years) presented with heel pain. All patients underwent routine laboratory and radiological investigations e.g. radiographs, MRI and skeletal scintigraphy as part of initial diagnostic work-up. In all patients the diagnosis of tuberculosis was confirmed based on histopathology or culture. Standard multi-drug anti-tubercular therapy (ATT) was administered for 15 months. All patients were subsequently followed up with clinical evaluation, laboratory investigations and imaging. Skeletal scintigraphy, MRI and radiographs were repeated at 12 to 15 months from the initiation of anti-tubercular treatment in all patients. Results: Five out of six patients had lytic lesions at presentation on radiographs. Four of these 5 patients also had surrounding sclerosis. Follow-up radiographs obtained 12-15 months after starting ATT, showed an increase in surrounding sclerosis with progressive reduction in area of osteopenia in four and mild sclerotic changes in one. In the remaining one patient radiograph were normal both at presentation and follow up. Three phase bone scintigraphy revealed increased blood flow and blood pool activity and 'hot spots' in 5 and a central photopenic area in the calcaneum in one patient at the time of diagnosis. After starting ATT, significant reduction in vascularity and reactive bone changes in 5 patients and mild improvement in one patient. MRI was done in three patients, which revealed hyperintense lesion with erosion of the superior articular surface in 2 and 'Bull's eye' lesion with a hypointense centre and a surrounding hyperintense rim on post contrast T1W images in one patient. Follow-up MRI showed intermediate signal intensity on T2 weighted images that corresponded to caseous necrosis and high signal intensity related to granulomas or effusion. Conclusion: Radiography alone may not always reveal the presence of disease or its activity in calcaneal tuberculosis. Skeletal scintigraphy has a promising role in the early detection of calcaneal tuberculosis, and in the subsequent follow-up. It also offers the added advantage of whole body screening to detect multiple foci. MRI seems to offer similar sensitivity and better specificity in the diagnosis and follow-up compared to skeletal scintigraphy. MRI also offers better characterization of tubercular lesions

2002-09-01

80

The natural history of disappearing bone tumours and tumour-like conditions  

Energy Technology Data Exchange (ETDEWEB)

We describe 27 cases of bone tumours or tumour-like lesions where there was spontaneous regression. The follow-up period was 2.8-16.7 years (average, 7.0 years). Fourteen of these cases were no longer visible on plain radiographs. Histological diagnosis included exostosis, eosinophilic granuloma, fibrous dysplasia, fibrous cortical defect, non-ossifying fibroma, osteoid osteoma and bone island. Most cases began to reduce in adolescence or earlier, although sclerotic type lesions showed their regression in older patients. All lesions thought to be eosinophilic granuloma began to regress after periods of less than 3 months, while the duration of the other lesions showed wide variation (1-74 months). As resolution of the lesions took between 2 and 79 months (mean, 25.0 {+-} 20.3 months) we consider that the most likely mechanism was recovery of normal skeletal growth control. In exostosis with fracture, alteration of vascular supply may contribute to growth arrest, but not to subsequent remodelling stage. In inflammatory-related lesions such as eosinophilic granuloma, cessation of inflammation may be the mechanism of growth arrest, whilst temporary inflammation may stimulate osteogenic cells engaged in remodeling. In the sclerotic type, growth arrest is a less probable mechanism. Necrosis within the tumour and/or local changes in hormonal control, plus remodelling of the sclerotic area takes longer. Knowledge of the potential for spontaneous resolution may help in management of these tumour and tumour-like lesions of bone. Yanagawa, T. et al. (2001)

Yanagawa, Takashi; Watanabe, Hideomi; Shinozaki, Tetsuya; Ahmed, Adel Refaat; Shirakura, Kenji; Takagishi, Kenji

2001-11-01

 
 
 
 
81

The natural history of disappearing bone tumours and tumour-like conditions  

International Nuclear Information System (INIS)

We describe 27 cases of bone tumours or tumour-like lesions where there was spontaneous regression. The follow-up period was 2.8-16.7 years (average, 7.0 years). Fourteen of these cases were no longer visible on plain radiographs. Histological diagnosis included exostosis, eosinophilic granuloma, fibrous dysplasia, fibrous cortical defect, non-ossifying fibroma, osteoid osteoma and bone island. Most cases began to reduce in adolescence or earlier, although sclerotic type lesions showed their regression in older patients. All lesions thought to be eosinophilic granuloma began to regress after periods of less than 3 months, while the duration of the other lesions showed wide variation (1-74 months). As resolution of the lesions took between 2 and 79 months (mean, 25.0 ± 20.3 months) we consider that the most likely mechanism was recovery of normal skeletal growth control. In exostosis with fracture, alteration of vascular supply may contribute to growth arrest, but not to subsequent remodelling stage. In inflammatory-related lesions such as eosinophilic granuloma, cessation of inflammation may be the mechanism of growth arrest, whilst temporary inflammation may stimulate osteogenic cells engaged in remodeling. In the sclerotic type, growth arrest is a less probable mechanism. Necrosis within the tumour and/or local changes in hormonal control, plus remodelling of the sclerotic area takes longer. Knowledge of the potential for spontaneous resolution may help in management of these tumour and tumour-like lesions of bone. Yanagawa, T. et al. (2001)

2001-11-01

82

Histologia e ultraestrutura do rim e rim cefálico do pacu Histology and ultrastructure of kidney and cephalic kidney in Pacu  

Directory of Open Access Journals (Sweden)

Full Text Available O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de cada órgão com o uso de microscopia de luz e microscopia eletrônica de transmissão. O resultado da análise macroscópica mostrou que a localização do rim e rim cefálico são as mesmas encontradas na maioria dos teleósteos. O rim apresentou uma forma em "H", onde a região média se expandia sobre a bexiga natatória. O rim cefálico se apresentou como uma dilatação na região cranial do rim, mostrando-se bem visível. Na microscopia eletrônica de transmissão também foram observadas similaridades ultraestruturais com outros teleósteos. Observando nossos resultados concluímos que histologicamente e ultraestruturalmente, os órgãos linfóides rim e rim cefálico de Piaractus mesopotamicus são similares aos de outros teleósteos.The Pacu, Piaractus mesopotamicus, is a teleostei of the Characidae family, intensively cultivated in Brazil due to its rusticity, fast growth and easy adaptation. Morphological knowledge of the body systems including the lymphoid organs is necessary to improve fish production and supply subsidies for the maintenance of stocks. This study aimed to describe morphologically kidney and head kidney of Piaractus mesopotamicus, analyzing the cellular profile of each organ with the use of light microscopy and electronic transmission microscopy. The result of the macroscopic analysis showed that the localization of the kidney and head kidney is the same as found in the majority of the teleostei. The kidney presented a form in "H", where the medium region is expanded on the natatorium bladder. The head kidney presented a dilatation in the cranial region of the kidney. In the transmission electronic microscopy we found ultrastructural similarities with other teleostei fish. It can be concluded that the lymphoid organs (kidney and head kidney of Piaractus mesopotamicus are histologically and ultra-structurally similar to the other teleostei.

Gerlane M. Costa

2012-05-01

83

Histologia e ultraestrutura do rim e rim cefálico do pacu / Histology and ultrastructure of kidney and cephalic kidney in Pacu  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O pacu, Piaractus mesopotamicus, é um teleósteo da Família Characidae, intensivamente cultivado no Brasil devido sua rusticidade, crescimento rápido e fácil adaptação. O conhecimento morfológico dos sistemas corpóreos, incluído órgãos linfóide, se faz necessário, para uma melhor produção no cultivo [...] de peixes, fornecendo subsídios na manutenção dos estoques. O objetivo deste estudo foi descrever morfologicamente o rim e rim cefálico de Piaractus mesopotamicus, analisando os perfis celulares de cada órgão com o uso de microscopia de luz e microscopia eletrônica de transmissão. O resultado da análise macroscópica mostrou que a localização do rim e rim cefálico são as mesmas encontradas na maioria dos teleósteos. O rim apresentou uma forma em "H", onde a região média se expandia sobre a bexiga natatória. O rim cefálico se apresentou como uma dilatação na região cranial do rim, mostrando-se bem visível. Na microscopia eletrônica de transmissão também foram observadas similaridades ultraestruturais com outros teleósteos. Observando nossos resultados concluímos que histologicamente e ultraestruturalmente, os órgãos linfóides rim e rim cefálico de Piaractus mesopotamicus são similares aos de outros teleósteos. Abstract in english The Pacu, Piaractus mesopotamicus, is a teleostei of the Characidae family, intensively cultivated in Brazil due to its rusticity, fast growth and easy adaptation. Morphological knowledge of the body systems including the lymphoid organs is necessary to improve fish production and supply subsidies f [...] or the maintenance of stocks. This study aimed to describe morphologically kidney and head kidney of Piaractus mesopotamicus, analyzing the cellular profile of each organ with the use of light microscopy and electronic transmission microscopy. The result of the macroscopic analysis showed that the localization of the kidney and head kidney is the same as found in the majority of the teleostei. The kidney presented a form in "H", where the medium region is expanded on the natatorium bladder. The head kidney presented a dilatation in the cranial region of the kidney. In the transmission electronic microscopy we found ultrastructural similarities with other teleostei fish. It can be concluded that the lymphoid organs (kidney and head kidney) of Piaractus mesopotamicus are histologically and ultra-structurally similar to the other teleostei.

Gerlane M., Costa; Ana R., Lima; Mendelson G. de, Lima; José R, Kfoury Jr.

84

Design analysis of Hub, Rim and Drum in Brake Assembly  

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Full Text Available Stress analysis connected with the brake assembly of heavy vehicles is a complicated problem in view of the machine elements involved. The hub (on the rear axle, the rim (holding the wheel and the drum (holding the brake shoe experience severity of loads. While the vehicle is being driven the power is transmitted from the hub to the rim. When the brake is applied, the brake drum receives the braking torque and communicates it to the rim. Analysis associated with braking is actually transient since the braking torque varies with time in a short period of time whereas the one associated with driving is predominantly steady while the vehicle moves with uniform speed. None of them can be considered rotationally symmetric. Even though 3D brick element can be used for modelling all the three members, the computational effort needed to handle the problem of braking becomes extremely cumbersome. Hence a compromise solution is presented in this paper.

Ramamurti V.

2013-01-01

85

Molecular Kinematics Tracers in Bright-Rimmed Cloud SFO14  

Science.gov (United States)

The star cluster AFGL4029 and associated nebulosity IC1848 (herein referred to as bright-rimmed cloud SFO14) has been forwarded by numerous studies as an example of small-scale sequential star formation (S4F), in which star formation proceeds across a region as the result of triggering mechanisms such as Collect-and-Collapse and Radiative Driven Implosion (RDI). We would like to develop a detailed picture of the molecular dynamical interactions within SFO14 (and other regions where RDI may be responsible for star formation) in order to see if the dynamics within the cloud can be linked to the conditions in the HII region beyond the rim. We present multi-wavelength observations of the bright-rimmed cloud SFO14 in NH3(1,1) and (2,2) inversion transitions and 12CO, 13CO, and C18O (J=3->2) transitions. These observations allow determination of kinematics within the cloud (thermal and turbulent motions and outflows), cloud opacities, and kinetic temperatures. We identify two cores within SFO14: a larger primary core nearer the rim (associated with the known UCHII reigion AFGL4029-IRS1) and a weaker core approximately 2' east of the primary. These cores are apparent in both NH3 and CO maps, although positions of peak molecular emission vary by about 20". The primary core shows morphological evidence of interaction with the rim in both NH3 and CO species. These CO and NH3 observations combine with earlier observations (including 8 µm and radio emission maps) to make SFO14 one of the more convincing examples of RDI-triggered star formation. Extending these studies to a larger sample of bright-rimmed clouds is expected to verify the role of RDI as a significant contributor to the galactic IMF.

Figura, Charles C.; Morgan, L.; Moore, T.; Urquhart, J.

2011-01-01

86

Lower-Rim Substituted Calixarenes and Their Applications  

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Full Text Available This review discusses in detail “calixarenes” since their discovery as by-products of the phenol formaldehyde bakelites till the present scenario wherein calixarene has assumed a new dimension in the field of supramolecular chemistry. Extensive literature exists for calixarenes; but herein we have tried to concentrate on the different lower-rim modified calixarenes with their potential applications. An attempt has also been made to critically evaluate the synthesis procedures for different lower-rim substituted calixarenes.

Princy Jose

2007-03-01

87

Experimental study of THGEM detector with mini-rim  

CERN Multimedia

The gas gain and energy resolution of single and double THGEM detectors (5{\\times}5cm2 effective area) with mini-rims (rim is less than 10{\\mu}m) were studied. The maximum gain can reach 5{\\times}103 and 2{\\times}105 for single and double THGEM respectively, while the energy resolution of 5.9 keV X-ray varied from 18% to 28% for both single and double THGEM detectors of different hole sizes and thicknesses.All the experiments were investigated in mixture of noble gases(argon,neon) and small content of other gases(iso-butane,methane) at atmospheric pressure.

Zhang, Ai-Wu; Xie, Yu-Guang; Liu, Hong-Bang; An, Zheng-Hua; Wang, Zhi-Gang; Cai, Xiao; Sun, Xi-Lei; Shi, Feng; Fang, Jian; Xue, Zhen; Lu, Qi-Wen; Sun, Li-Jun; Ge, Yong-Shuai; Liu, Ying-Biao; Hu, Tao; Zhou, Li; Lu, Jun-Guang

2011-01-01

88

The Plasma Structure of the Cygnus Loop from the Northeastern Rim to the Southwestern Rim  

CERN Document Server

The Cygnus Loop was observed from the northeast to the southwest with XMM-Newton. We divided the observed region into two parts, the north path and the south path, and studied the X-ray spectra along two paths. The spectra can be well fitted either by a one-component non-equilibrium ionization (NEI) model or by a two-component NEI model. The rim regions can be well fitted by a one-component model with relatively low \\kTe whose metal abundances are sub-solar (0.1--0.2). The major part of the paths requires a two-component model. Due to projection effects, we concluded that the low kTe (about 0.2 keV) component surrounds the high kTe (about 0.6 keV) component, with the latter having relatively high metal abundances (about 5 times solar). Since the Cygnus Loop is thought to originate in a cavity explosion, the low-kTe component originates from the cavity wall while the high-kTe component originates from the ejecta. The flux of the cavity wall component shows a large variation along our path. We found it to be ve...

Tsunemi, Hiroshi; Nemes, Norbert; Miller, Eric D

2007-01-01

89

Parosteal osteoma of the iliac bone  

International Nuclear Information System (INIS)

A 33-year-old patient with a 2-year history of intermittent pain in the right gluteal region and thigh presented with a large sclerotic lesion of the iliac bone. From the findings on radiography, scintigraphy, CT and MRI, a giant parosteal osteoma was suspected. The histological examination confirmed the diagnosis. Since the lesion was extensive it was observed with periodic follow-up examinations. At present, 5 years after the diagnosis, the patient is asymptomatic and imaging studies show that the lesion persists with reduction of sclerosis and size. The tumor was on the surface as well as intramedullary -only one other case with such a distribution is known to us - and it was also in the iliac bone. (orig.)

1998-03-01

90

Structural Modeling of a Thick-Rim Rotor.  

Science.gov (United States)

A NASTRAN structural model has been constructed of the Sandia designed, thick-rim rotor having six discrete overwrapped bands forming twelve pairs of spokes--the wagon-wheel rotor. The results of an experimental modal analysis of an actual rotor, using Fa...

A. K. Miller

1978-01-01

91

Imaging signs and diagnosis of bone echinococcosis  

International Nuclear Information System (INIS)

Objective: To evaluate the value of imaging investigations in the diagnosis of bone echinococcosis by analysing the X-ray, CT and MBI signs. Methods: Imaging data of 7 patients aged from 23 to 56 years ( mean age 39.5 years) with bone echinococcosis were analysed retrospectively. All cases underwent X-ray plain film examination (frontal view and lateral view); 4 cases were examined with CT; 3 cases received MRI scan. Results: The echinococcosis located in skull (1 case), vertebrae (3 cases), sacrum (1 case), ilium(1 case )and ribs (1 case) respectively. X-ray signs: 5 cases appeared as expanding destructive lesion, two of them were solitary cystic lesions, the others were multiple cystic lesions. Lyric destruction was showed in 2 cases. Sclerotic margin, calcification, soft tissue mass was visible in 5, 1 and 4 cases respectively. CT signs: 3 of 4 cases were expanding destructive lesions, including 2 multiple cystic lesions and 1 solitary cystic destruction. The other one showed lytic destruction. 3 had sclerotic margin; calcification was identified in 2 cases, 4 cases accompanied with soft tissue mass. MRI signs: All of 3 cases occurred at vertebrae, solitary cystic lesion in one and multiple cystic lesions in two. Lesions showed low signal on T1WI image, high signal on T2WI image and appeared as grape shapes. Involved vertebrae showed wedge-shaped. Conclusion: Imaging modalities were significantly valuable in the diagnosis of bone echinococcosis. Combination of X-ray radiography, CT, MRI and epidemiological information is helpful in the diagnosis and differential diagnosis of the bone echinococcosis. (authors)

2007-03-01

92

Bone Grafts  

Science.gov (United States)

A bone graft transplants bone tissue. Surgeons use bone grafts to repair and rebuild diseased bones in your hips, knees, spine, and sometimes other bones and joints. Grafts can also repair bone loss caused by some ...

93

49 CFR 571.110 - Tire selection and rims and motor home/recreation vehicle trailer load carrying capacity...  

Science.gov (United States)

...Rim Engineering Data Committee of South Africa (Tredco). (6) âSâ indicates Scandinavian Tire and Rim Organization (STRO). (7) âAâ indicates The Tyre and Rim Association of Australia. (8) âIâ indicates Indian Tyre Technical...

2010-10-01

94

Lower-Rim Substituted Calixarenes and Their Applications  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This review discusses in detail “calixarenes” since their discovery as by-products of the phenol formaldehyde bakelites till the present scenario wherein calixarene has assumed a new dimension in the field of supramolecular chemistry. Extensive literature exists for calixarenes; but herein we have tried to concentrate on the different lower-rim modified calixarenes with their potential applications. An attempt has also been made to critically evaluate the synthesis...

2007-01-01

95

Hemangioendotelioma Hepático Infantil e Rim Displásico Multiquístico: uma nova associação?  

Scientific Electronic Library Online (English)

Full Text Available SciELO Portugal | Language: Portuguese Abstract in portuguese O hemangioendotelioma hepático infantil tem uma incidência que é a terceira entre os tumores hepáticos da criança e é o tumor benigno hepático vascular mais frequente na infância. Apresentamos o caso clínico de uma criança com o diagnóstico de hemangioendotelioma hepático associado a rim displásico [...] multiquístico transitório. O diagnóstico de rim multiquístico foi confirmado por ecografia no período pré e pós natal. Numa ecografia realizada aos 5 meses detectaram-se lesões hepáticas sugestivas de hemangioendotelioma. Realizou ressonância magnética aos 8 meses que não mostrou o rim direito. A biópsia hepática confirmou o diagnóstico de hemangioendotelioma infantil tipo1. Em ecografias seriadas verificou-se redução das lesões hepáticas que desapareceram aos 19 meses. Esta associação de hemangioendotelioma hepático e rim multiquístico não se encontra descrita, embora sejam conhecidas associações com agenesia renal. Abstract in english Infantile hemangioendothelioma has an incidence that is the third most common between hepatic tumours in children and the most common benign vascular tumour of the liver in infancy. In this paper we report a clinical case of a child with hepatic hemangioendothelioma associated with a transitory mult [...] icystic dysplastic kidney. The multicystic disorder was evident pre and post natally. At 5 months an ultrasonography imaging showed multiple hepatic lesions suggestive of hemangioendothelioma. At 8 months a magnetic resonance imaging did not show the right kidney. Hepatic biopsy confirmed the diagnosis of infantile hemangioendothelioma. On ultrasonographies performed during follow up focal hepatic lesions reduced and disappeared by 19 months. This association has not been reported although cases associated with unilateral renal agenesis are known.

Moura, M. Carneiro de; Nunes, P. Sampaio; Flores, H.; Lemos, P. Sande.

96

Hemangioendotelioma Hepático Infantil e Rim Displásico Multiquístico: uma nova associação?  

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Full Text Available O hemangioendotelioma hepático infantil tem uma incidência que é a terceira entre os tumores hepáticos da criança e é o tumor benigno hepático vascular mais frequente na infância. Apresentamos o caso clínico de uma criança com o diagnóstico de hemangioendotelioma hepático associado a rim displásico multiquístico transitório. O diagnóstico de rim multiquístico foi confirmado por ecografia no período pré e pós natal. Numa ecografia realizada aos 5 meses detectaram-se lesões hepáticas sugestivas de hemangioendotelioma. Realizou ressonância magnética aos 8 meses que não mostrou o rim direito. A biópsia hepática confirmou o diagnóstico de hemangioendotelioma infantil tipo1. Em ecografias seriadas verificou-se redução das lesões hepáticas que desapareceram aos 19 meses. Esta associação de hemangioendotelioma hepático e rim multiquístico não se encontra descrita, embora sejam conhecidas associações com agenesia renal.Infantile hemangioendothelioma has an incidence that is the third most common between hepatic tumours in children and the most common benign vascular tumour of the liver in infancy. In this paper we report a clinical case of a child with hepatic hemangioendothelioma associated with a transitory multicystic dysplastic kidney. The multicystic disorder was evident pre and post natally. At 5 months an ultrasonography imaging showed multiple hepatic lesions suggestive of hemangioendothelioma. At 8 months a magnetic resonance imaging did not show the right kidney. Hepatic biopsy confirmed the diagnosis of infantile hemangioendothelioma. On ultrasonographies performed during follow up focal hepatic lesions reduced and disappeared by 19 months. This association has not been reported although cases associated with unilateral renal agenesis are known.

M. Carneiro de Moura

2009-03-01

97

Compactly supported solutions for a rimming flow model  

Science.gov (United States)

We study a generally ill-posed Cauchy problem with 2?-periodic initial data for a nonlinear forward–backward heat equation. The problem is originated from a lubrication approximation of viscous rimming flow dynamics on the inner surface of a rotating horizontal cylinder in the presence of gravitational field. For a certain class of compactly supported initial data we prove local in time existence of generalized weak solutions.

Chugunova, Marina; Pyatkov, Sergey

2014-04-01

98

View of 'Bottomless Bay' on Rim of 'Victoria'  

Science.gov (United States)

As part of its investigation of 'Victoria Crater,' NASA's Mars Exploration Rover Opportunity examined a section of the scalloped rim called 'Bottomless Bay' (or 'Bahia sin Fondo'). This view shows the northeastern side of Bottomless Bay as seen from the southwest. The exposures combined into this mosaic were taken by the rover's panoramic camera through a 750-nanometer filter during the 1,019th Martian day, or sol, of Opportunity's Mars-surface mission (Dec. 5, 2006).

2006-01-01

99

Ultrasonic Resonance Spectroscopy of Composite Rims for Flywheel Rotors  

Science.gov (United States)

Flywheel energy storage devices comprising multilayered composite rotor systems are being studied extensively for utilization in the International Space Station. These composite material systems were investigated with a recently developed ultrasonic resonance spectroscopy technique. The ultrasonic system employs a continuous swept-sine waveform and performs a fast Fourier transform (FFT) on the frequency response spectrum. In addition, the system is capable of equalizing the amount of energy at each frequency. Equalization of the frequency spectrum, along with interpretation of the second FFT, aids in the evaluation of the fundamental frequency. The frequency responses from multilayered material samples, with and without known defects, were analyzed to assess the capabilities and limitations of this nondestructive evaluation technique for material characterization and defect detection. Amplitude and frequency changes were studied from ultrasonic responses of thick composite rings and a multiring composite rim. A composite ring varying in thickness was evaluated to investigate the full thickness resonance. The frequency response characteristics from naturally occurring voids in a composite ring were investigated. Ultrasonic responses were compared from regions with and without machined voids in a composite ring and a multiring composite rim. Finally, ultrasonic responses from the multiring composite rim were compared before and after proof spin testing to 63,000 rpm.

Harmon, Laura M.; Baaklini, George Y.

2002-01-01

100

Analysis of rim effect in high burnup LWR fuel  

International Nuclear Information System (INIS)

238U epithermal absorption cross section is larger near the surface than around the center in LWR fuel. More Pu is produced and burns up near the surface. Therefore burnup and power density is enhanced near the surface, which is called rim effect. A detailed burnup code VIMBRN which can analyze rim effect has been developed and verified by experimental data. Development of the fule available for high burnup is carried out in HALDEN reactor (HBWR). In a result of VIMBURN code calculation, rim effect is found smaller in HBWR than in commercial BWR. The difference is attributed to neutron spectra in these reactors. To evaluate the thermal conductivity in the fuel, Pu quantity model was constructed which provides Pu atom ratio and Pu burnup ratio in various enrichment. O/M(M=U+Pu) was calculated in a sequence of burnup by the model and FP yields, so O/M on the surface was over 2 in high burnup. It is shown that thermal conductivity decreases to a lower level at high burnup. (author)

1990-01-01

 
 
 
 
101

Bone Diseases  

Science.gov (United States)

... brittle Paget's disease of bone makes them weak Bone disease can make bones easy to break Bones can also develop cancer and infections Other bone diseases are caused by poor nutrition, genetic factors or ...

102

Bone tumors  

International Nuclear Information System (INIS)

This book contains the proceedings on bone tumors. Topics covered include: Bone tumor imaging: Contribution of CT and MRI, staging of bone tumors, perind cell tumors of bone, and metastatic bone disease

1988-01-01

103

Bone tumors  

Energy Technology Data Exchange (ETDEWEB)

This book contains the proceedings on bone tumors. Topics covered include: Bone tumor imaging: Contribution of CT and MRI, staging of bone tumors, perind cell tumors of bone, and metastatic bone disease.

Unni, K.K. (Dept. of Pathology, Mayo Medical School, Rochester, MN (US))

1988-01-01

104

A SCUBA survey of bright-rimmed clouds  

Science.gov (United States)

Context: Bright-rimmed clouds (BRCs) are potential examples of triggered star formation regions, in which photoionisation driven shocks caused by the expansion of HII regions induce protostellar collapse within the clouds. Aims: The main purpose of the paper is to establish the level of star formation occuring within a known set of BRCs. A secondary aim is to determine the extent, if any, to which this star formation has been promulgated by the process of photoionisation triggering. Methods: A primary set of observations is presented obtained with submillimeter SCUBA observations and archival data from near-IR and mid- to far-IR have been explored for relevant observations and incorporated where appropriate. Results: SCUBA observations show a total of 42 dense cores within the heads of 44 observed BRCs drawn from a catalogue of IRAS sources embedded within HII regions, supportive of the scenario proposed by RDI models. The physical properties of these cores indicate star formation across the majority of our sample. This star formation appears to be predominately in the regime of intermediate to high mass and may indicate the formation of clusters. IR observations indicate the association of early star forming sources with our sample. A fundamental difference appears to exist between different morphological types of BRC, which may indicate a different evolutionary pathway toward star formation in the different types of BRC. Conclusions: Bright-rimmed clouds are found to harbour star formation in its early stages. Different evolutionary scenarios are found to exist for different morphological types of BRC. The morphology of a BRC is described as type “A”, moderately curved rims, type “B”, tightly curved rims, and “C”, cometary rims. “B” and “C” morphological types show a clear link between their associated star formation and the strength of the ionisation field within which they are embedded. An analysis of the mass function of potentially induced star-forming regions indicate that radiatively-driven implosion of molecular clouds may contribute significantly toward the intermediate to high-mass stellar mass function. Appendix is only available in electronic form at http://www.aanda.org

Morgan, L. K.; Thompson, M. A.; Urquhart, J. S.; White, G. J.

2008-01-01

105

Electric pulse treatment of rim wheel metal after operation  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction. Load increase on the wheel pair ax requires the use of railway wheels with the advanced complex of properties. Except strength properties, the properties of metal resistance to defect nucleation on the wheel thread are of high importance. The above mentioned properties increase is possible by using different technological decisions: alloying and heat strengthening. Purpose. The purpose is an attempt to estimate the softening degree of the wheel thread metal using the electric pulse treatment. Methodology. Electric pulse treatment (ET was carried out on the special plant in the conditions of JSC DS (Nikolayev city. As the property of metal strength the Vickers hardness number is used. The microstructure research was carried out using the light microscope. The material for research is the carbon steel of the rim fragment of railway wheel ?181732, withdrawn after operation, containing 0,55%?, 0,74%Mn, 0,33%Si, 0,009%P, 0,01%S, 0,06% Ni, 0,1%Cr, 0,08%Cu. Findings. Exposing the rim fragment to electric pulse treatment (ET, the qualitative changes of internal structure of the wheel rim metal corresponded to the experimentally observed geometrical dimensions change of the specimen, depending on the cycles number. As a result of the treatment the reduction of cold strained metal hardness is observed. It was found out 20 % softening on the wheel thread for the ? rim area the, for the ?? rim area the 8% softening and for the ??? 11% softening in relation to the initial state. Originality. As a result of electric pulse treatment, the change of the specimen geometrical dimensions is observed. Depending on the number of cycles it causes softening effect. It is proved that the observed softening value during ET is qualitatively connected with the cold strain level on the rail wheel thread. Practical value. As a result of metal cold work on the wheel thread its resistance to the defect nucleation is being reduced. The resulted data can be used during elaboration of measures to increase the operational safety of railway transport The technology development of the strain hardening embrittling influence reduce is an important scientific direction in further researches.

L.I.Vakulenko

2013-02-01

106

Hydrogeology associated to faulting of the Chicxulub Impact Crater rim  

Science.gov (United States)

The only surface expression of the Chicxulub Impact Crater is a Ring of Cenotes (sinkholes) whose density varies from several cenotes per kilometer, to several kilometers between each cenote. This ring has a radius of approximately 90 km and it is centered at Chicxulub Puerto. It is not known today whether the Ring of Cenotes is the surface expression of the transient cavity as some authors have suggested, or whether it is the outer rim of the impact structure. The center of the ring is approximately coincident with the center of the Chicxulub Impact Crater. Reactivation of K/T rim faults had been associated to the formation of the ring of cenotes. However, none of these models project such faults to the Tertiary sedimentary sequence; therefore we can only infer that the cenotes are associated to these faults. Other hypotheses include "post impact subsidence induced by slumping and viscous relaxation in the rim" and "slumping in the rim of the buried crater, differential thickness in the rocks overlying the crater, or solution collapse within porous impact deposits", others suggest duration of subaerial exposure and weathering as a principal reason both for difference in permeability and cenote density inside and outside the Ring. This is consistent with the evolution of surface features reported. While sedimentation occurred in the basin outlined by the Ring, erosion and karst weathering were taking place outside the Ring. The karst features are associated with gravity gradients, which have been interpreted as corresponding to peripheral faults of the buried crater. We conducted geoelectric tomography perpendicular to the ring of cenotes, where we mapped the karstic features in the area and we interpret the high permeability in this area, to be associated to the faults generated by the differential compaction of the sedimentary sequence within the crater. This fault system generates a secondary porosity with high permeability that allows the circulation of water, which, in turn, will dissolve the carbonates of the roof and hanging walls of the faults. Another group of cenotes, that is not related to the ring of cenotes, is the alignment of >100 km long chains of elongated solution depressions locally known as sabanas along the Holbox fracture zone-Xel-Ha zone; these alignments support the hypothesis of generation of karst features associated to weakness zones in major fractures zones, such as Holbox fracture zone-Xel-Ha zone and the Chicxulub crater rim.

Rebolledo-Vieyra, M.; Hernandez-Terrones, L.; Almazan-Becerril, A.; Valadez-Cruz, F.

2011-12-01

107

Bone metastases in stomach cancer patients: comparison of Tc-99m HDP scintigraphy and FDG PET/CT scan  

International Nuclear Information System (INIS)

To evaluate the values of FDG PET/CT and Tc-99m HDP bone scan in the detection of bone metastases in stomach cancer patients. PET/CT and bone scan images obtained within a month of each other from patients with confirmed stomach cancer, from November 2003 to November 2006, were evaluated. The number and location of the bone lesions were noted. On PET ICT, discrete focal FDG uptake distinguishable from the background cortex or marrow activity was considered a positive finding. The CT portion of the PET/CT was also reviewed for osteoblastic or osteolytic lesions. Confirmation was made by further follow up images with PET/CT, bone scan, CT, and/or MRI. Images of 203 patients were included (69 female, 134 male, average age 60.5 yrs), of which 187 cases were concluded as free from bone metastasis and 16 cases positive for bone metastases. On patient basis, the overall sensitivity, specificity, and accuracy of PET/CT were 99.5%, 87.5%, and 98.5%, and of bone scan were 96.8%, 75.0%, and 95.1 %, respectively. On lesion basis, PET/CT detected more lesions in the cervical vertebrae, while bone scan detected more lesions in the rib cage and skull. There were 5 cases where PET/CT missed lesions seen on bone scan, and the CT portion of the PET/CT demonstrated sclerotic lesions in 3 cases, mixed osteolytic and sclerotic lesion in 1 case, and equivocal finding in 1 other case. In the diagnosis of bone metastasis in stomach cancer patients, PET/CT showed higher accuracy than bone scan. However, bone scan detected more lesions in the ribs and skull. The CT portion of the PET/CT should be carefully examined for osteoblastic metastases

2007-10-26

108

18F-FDG PET/CT bone/bone marrow findings in Hodgkin's lymphoma may circumvent the use of bone marrow trephine biopsy at diagnosis staging  

International Nuclear Information System (INIS)

Accurate staging of Hodgkin's lymphoma (HL) is necessary in selecting appropriate treatment. Bone marrow trephine biopsy (BMB) is the standard procedure for depicting bone marrow involvement. BMB is invasive and explores a limited part of the bone marrow. 18F-FDG PET/CT is now widely used for assessing response to therapy in HL and a baseline study is obtained to improve accuracy. The aim of this retrospective analysis was to assess whether routine BMB remains necessary with concomitant 18F-FDG PET/CT. Data from 83 patients (newly diagnosed HL) were reviewed. All patients had received contrast-enhanced CT, BMB and 18F-FDG PET/CT. Results of BMB were not available at the time of 18F-FDG PET/CT imaging. Seven patients had lymphomatous involvement on BMB. Four patients had bone involvement on conventional CT (two with negative BMB). All patients with bone marrow and/or bone lesions at conventional staging were also diagnosed on 18F-FDG PET/CT scan. PET/CT depicted FDG-avid bone/bone marrow foci in nine additional patients. Four of them had only one or two foci, while the other had multiple foci. However, the iliac crest, site of the BMB, was not involved on 18F-FDG PET/CT. Osteolytic/sclerotic lesions matching FDG-avid foci were visible on the CT part of PET/CT in three patients. MRI ordered in three other patients suggested bone marrow involvement. Interim and/or end-therapy 18F-FDG PET/CT documented response of FDG-avid bone/bone marrow foci to chemotherapy in every patient. 18F-FDG PET/CT highly improves sensitivity for diagnosis of bone/bone marrow lesions in HL compared to conventional staging. (orig.)

2010-06-01

109

The detection of sclerotic changes of the coronaries and heart valves by scanning beams (ultrafast computed tomography using EVOLUTION). Diagnostik von Coronar- und Herzklappenverkalkungen mit dem Elektronenstrahl-CT (Ultrafast-CT, Evolution)  

Energy Technology Data Exchange (ETDEWEB)

With the advent of ultrafast computed tomography the range of diagnostic procedures for the quantitative determination of pathological changes in the coronary arteries has been broadened. The calcified coronary plaques found in this study, which in some of the patients were markedly pronounced, gave no immediate clue as to what extent sclerotic changes had already occurred in the coronaries examined. Nor was it possible on the basis of this method to pinpoint the vascular sections showing calcified plaques in patients undergoing maintenance dialysis. It may, however, permit careful predictions to be made for patients at a high risk of developing coronary artery disease. Sclerotic changes of the heart values occur with above-average frequency in dialysis patients and may be assessed quantitatively by the method described. The results described show that findings revealed by scanning electron beams may provide indirect information on metabolic processes in patients suffering from chronic ailments. (orig./MG)

Oldendorf, M. (Abt. fuer Roentgendiagnostik, Klinikum Nord der Stadt Nuernberg (Germany)); Zeitler, E. (Abt. fuer Roentgendiagnostik, Klinikum Nord der Stadt Nuernberg (Germany)); Braun, J. (Abt. fuer Roentgendiagnostik, Klinikum Nord der Stadt Nuernberg (Germany)); Weber, P. (Abt. fuer Roentgendiagnostik, Klinikum Nord der Stadt Nuernberg (Germany))

1994-02-01

110

RIMS diagnostics for laser desorption/laser ablation  

Energy Technology Data Exchange (ETDEWEB)

Laser desorption mass spectrometry is a useful method for interrogating materials and events at or near surfaces. Laser desorption/ablation combined with Resonance Ionization Mass Spectrometry (RIMS) provides a powerful tool to obtain information on chemical composition and speciation and, in some cases, internal and translational energy distributions. The application of this technique to the interrogation of materials and interfaces is discussed for several systems, including the analysis of conventional analytical samples, and the study of optical damage events. 8 refs., 2 figs., 1 tab.

Apel, E.C.; Nogar, N.S.; Miller, C.M.; Estler, R.C.

1986-01-01

111

RIMS diagnostics for laser desorption/laser ablation  

International Nuclear Information System (INIS)

Laser desorption mass spectrometry is a useful method for interrogating materials and events at or near surfaces. Laser desorption/ablation combined with Resonance Ionization Mass Spectrometry (RIMS) provides a powerful tool to obtain information on chemical composition and speciation and, in some cases, internal and translational energy distributions. The application of this technique to the interrogation of materials and interfaces is discussed for several systems, including the analysis of conventional analytical samples, and the study of optical damage events. 8 refs., 2 figs., 1 tab

1986-09-07

112

Frequency analysis of a thick-rim flywheel. [NONSAP  

Energy Technology Data Exchange (ETDEWEB)

The calculation of natural frequencies of a thick-rim flywheel is presented using two analysis methods: the finite-element method and the transfer matrix method. A listing of the computer program developed using the transfer matrix method is included. The results of the finite-element analyses indicate that the computer programs NONSAP and ADINA are incapable of determining out-of-plane natural frequencies of the flywheel. The results of the analysis using the transfer matrix method are satisfactory for out-of-plane as well as in-plane frequencies.

Fanning, D. N.

1978-09-01

113

49 CFR 571.120 - Tire selection and rims and motor home/recreation vehicle trailer load carrying capacity...  

Science.gov (United States)

...Tire and Rim Association. (2) âEâ indicates The European Tyre and Rim Technical Organisation (3) âJâ indicates Japan...Scandinavian Tire and Rim Organization. (7) âAâ indicates The Tyre and Rim Association of Australia. (8) âNâ indicates...

2009-10-01

114

Three-dimensional simulation of threshold porosity for fission gas release in the rim region of LWR UO2 fuel  

International Nuclear Information System (INIS)

The threshold porosity above which fission gas release channels would be formed extensively in the rim region of high burnup UO2 fuel was estimated by the Monte Carlo method and Hoshen-Kopelman algorithm. With the assumption that both rim pore and rim grain can be represented by cubes, the pore distribution in the rim was simulated three-dimensionally by the Monte Carlo method according to rim porosity and pore size distribution. Using the Hoshen-Kopelman algorithm, the fraction of open rim pores interlinked to the outer surface of a fuel pellet was derived as a function of the rim porosity. The simulation revealed that it is the rim porosity rather than the pore size distribution or rim thickness that determines the fraction of open pores connected to the pellet surface. The analysis also indicated that the threshold porosity is around 24%, above which the number of rim pores forming release channels increases very rapidly

2003-09-15

115

Computed tomographic scanning and radioisotope bone scanning  

International Nuclear Information System (INIS)

We report here a comparative study of bone scans, radiographs, and computed tomographic (CT) scanning in 30 patients with cancer of the breast. All the bone scans had focally increased uptake in the axial skeleton and were assessed with the corresponding radiographs. CT scans were made of the regions of focally increased uptake. In three patients with solitary bone scan abnormalities, two were shown on CT scans to have lytic and sclerotic lesions when the conventional radiographs showed only osteophytes and degenerative joint disease, and in one patient CT scans demonstrated degenerative disease of a costovertebral joint not shown on the radiographs. In two patients with multifocal abnormalities in the lumbar spine that could be accounted for by benign disease shown on the CT scans, radiography could explain only one lesion. In the remaining patients, there was agreement between the three methods. The results confirm the importance of excluding benign causes for bone scan abnormalities. (orig./MG) 891 MG/orig.- 892 MB

1979-01-01

116

Optimization of Hydride Rim Formation in Unirradiated Zr 4 Cladding  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this work is to build on the results reported in the M2 milestone M2FT 13PN0805051, document number FCRD-USED-2013-000151 (Hanson, 2013). In that work, it was demonstrated that unirradiated samples of zircaloy-4 cladding could be pre-hydrided at temperatures below 400°C in pure hydrogen gas and that the growth of hydrides on the surface could be controlled by changing the surface condition of the samples and form a desired hydride rim on the outside diameter of the cladding. The work performed at Pacific Northwest National Laboratory since the issuing of the M2 milestone has focused its efforts to optimize the formation of a hydride rim on available zircaloy-4 cladding samples by controlling temperature variation and gas flow control during pre-hydriding treatments. Surface conditioning of the outside surface was also examined as a variable. The results of test indicate that much of the variability in the hydride thickness is due to temperature variation occurring in the furnaces as well as how hydrogen gas flows across the sample surface. Efforts to examine other alloys, gas concentrations, and different surface conditioning plan to be pursed in the next FY as more cladding samples become available

Shimskey, Rick W.; Hanson, Brady D.; MacFarlan, Paul J.

2013-09-30

117

Externally Influenced Evolution in Bright-Rimmed Cloud SFO 14  

Science.gov (United States)

Bright-Rimmed Clouds (BRCs) are situated on the periphery of HII regions and are suspected sites of triggered star formation via the the mechanism of Radiative Driven Implosion (RDI). The focus of this study is to investigate the conditions within one BRC and determine the effects of the ionizing radiation on star formation and cloud evolution. We present multi-wavelength observations of the BRC SFO14 (IC 1848A) in NH3(1,1) and (2,2), CCS(J=2-1), and CO(J=3-2). These observations are complemented with archival Spitzer data. The NH3(1,1) emission maps two cores within SFO14, the larger of which is coincident with star forming region AFGL 4029 and a SCUBA submillimetre core previously reported by Morgan et al. (accepted). This extended emission around the core shows strong evidence of erosion by ionizing radiation (including elongation radially away from ionizing source BD +59 578). The velocity distribution of the elongation suggests that this core is located to the foreground of BD +59 578. NH3 inversion line measurements indicate rotation temperatures between 15K and 30K for the cloud, with higher rotation temperatures at the windward edge of the primary core nearest the cloud rim.

Figura, Charles C.; Morgan, L.; Urquhart, J.

2007-12-01

118

Chandra Observations of the Northeastern Rim of the Cygnus Loop  

CERN Document Server

We present results from spatially resolved spectral analyses of the northeastern (NE) rim of the Cygnus Loop supernova remnant (SNR) based on two Chandra observations. One pointing includes northern outermost abundance-enhanced regions discovered by recent Suzaku observations, while the other pointing is located on regions with "normal" abundances in the NE rim of the Cygnus Loop. The superior spatial resolving power of Chandra allows us to reveal that the abundance-enhanced region is concentrated in an about 200"-thickness region behind the shock front. We confirm absolute metal abundances (i.e., relative to H) as well as abundance ratios between metals are consistent with those of the solar values within a factor of about 2. Also, we find that the emission measure in the region gradually decreases toward the shock front. These features are in contrast with those of the ejecta fragments around the Vela SNR, which leads us to believe that the abundance enhancements are not likely due to metal-rich ejecta. We ...

Katsuda, Satoru; Kimura, Masashi; Mori, Koji

2008-01-01

119

Analysis of the energy capacity of rim-spoke composite flywheels  

International Nuclear Information System (INIS)

The rim-spoke flywheel consisting of a rim, connected to the hub by spokes encompassing the rim periphery, is one of the most promising types of energy accumulators. For the rational design of rim-spoke flywheels, the authors investigate the dependence of their mass energy capacity and their volume energy capacity; the limit speed on the geometric parameters of the flywheel and the properties of the composites used in making the rim and the spokes are also examined. It is shown through various programs, worked out for analyzing the energy capacity of rim-spoke flywheels, that they can substantially facilitate the designing of such flywheels according to specified requirements that their operational characteristics have to meet

1986-01-01

120

Simple bone cyst: MR findings  

International Nuclear Information System (INIS)

To describe the MR findings of simple bone cyst. We analyzed the signal intensity of the cystic contents, their margins, and internal septae, and the presence of bony fragment and pathologic fracture, and enhancement patterns in MRI of 10 pathologically confirmed simple bone cysts. On MR imaging, the cystic contents were of homogeneously low signal intensity on T1WI and high signal intensity on T2WI in nine cases and fluid-fluid level was seen in one case. The cystic margins were dark in all sequences. There were not any fragment in the cysts. Among the four cases with pathologic fracture, one case had fluid-fluid level and two had some areas of enhancement in the cyst or adjacent soft tissue. All nine cases with gadolinium enhancement showed thin rim enhancement along the inner margin of the cysts and internal septae. Homogeneous fluid-like signal intensity of cystic content and thin rim enhancement of margin and internal septae in MR imaging are believed to be helpful in the diagnosis of simple bone cyst

1994-12-01

 
 
 
 
121

Laboratory and field experience with rim ditch dewatering of MFT  

Energy Technology Data Exchange (ETDEWEB)

This PowerPoint presentation described a rim ditch method of dewatering mature fine tailings (MFT). Polymer additions were used to strengthen the MFT and to decrease the capillary suction time (CST). Laboratory and field-scale studies were conducted to demonstrate the dewatering method. The flocculants were added in a Komax inline mixer. Polymers were then injected into the tailings. The mixing processes were optimized in a series of laboratory studies and then demonstrated in the field tests. The tests showed that CST and high dewatering rates were consistently maintained using the method. MFT feeds were also consistent. Release water quality was improved using the method. The large-scale test site is now being monitored for compliance with Directive 74. tabs., figs.

Demoz, A.; Mikula, R. [Natural Resources Canada, Devon, AB (Canada). CANMET Western Research Centre; Lahaie, R. [Syncrude Canada Ltd., Edmonton, AB (Canada)

2010-07-01

122

Quantifying tire, rim, and vehicle effects on ride quality  

Energy Technology Data Exchange (ETDEWEB)

This paper discusses factors influencing vehicle ride discomfort are analyzed to separate those related to tires, rims, vehicles and other sources. Raw data is presented as vertical first harmonic accelerations, and is transformed into quantitative Ride Discomfort numbers using an empirical model developed by NASA. The results indicate each factor's quantitative contribution to ride discomfort. Ride discomfort numbers are compared against subjective data. Results are indicated as both a ride quality number and as a test set rejection parameter. The relation of a combination of known factors into subjective feelings of ride quality is discussed. An explanation is proposed that defines previously ambiguous results in terms of quantifiable sources of vehicle ride discomfort.

Kenny, T.M.

1989-01-01

123

Unusual Radar Backscatter along the Northern Rim of Imbrium Basin  

Science.gov (United States)

A viewgraph presentation of the unusual radar backscatter properties along the Northern Rim of Imbrium Basin is shown. The contents include: 1) Visual and Infrared Observations of Moon; 2) Radar Observations of Moon; 3) Lunar Orbiter Photographs Geologic Setting; 4) 70-cm Radar Data; 5) .70-cm Radar Dark Halo Craters; 6) 3.8-cm Radar Data; 7) 7.5-m Radar Data; 8) 70cm, 3.8 cm and 7.5-m Radar Data; 9) Optical and Infrared Data; 10) Plato Rilles; 11) Isopachs of Crater Ejecta; 12) Plato-like Craters; 13) Observation Summary; 14) Interpretation Matrix; 15) Dark Halo Diameters vs. Crater Size; and 16) Radar Geologic Column.

Thompson, Thomas W.; Campbell, Bruce A.; Ghent, Rebecca R.; Hawke, B. Ray; Leverington, David W.

2006-01-01

124

Coevolution of the Pacific salmon and Pacific Rim topography  

Science.gov (United States)

The late Cenozoic radiation of the Pacific salmon and trout (Oncorhynchus spp.) resulted in five species that are widely distributed in western North America and occupy distinct parts of river networks. The dramatic radiation of the Pacific salmon contrasts with the history of the Atlantic salmon, which have evolved little since the divergence of Oncorhynchus. Conventional hypotheses for the radiation of the Pacific salmon stress geographic isolation due to Pleistocene glaciations, but paleontological evidence dates their speciation to the middle Miocene to early Pliocene. Tertiary marine cooling may have spurred the development of anadromy in salmon and other fish, but does not readily explain the different evolutionary trajectories for the Pacific and Atlantic salmon. The timing of Pacific salmon speciation corresponds to significant physiographic changes around the Pacific Rim, suggesting that increased topographic diversity due to an active tectonic regime contributed to the evolution of the Pacific salmon.

Montgomery, David R.

2000-12-01

125

Donor corneoscleral rim contamination by gentamicin-resistant organisms  

Directory of Open Access Journals (Sweden)

Full Text Available Gentamicin is the most widely used antibiotic in the decontamination of donor cornea for penetrating keratoplasty. However, the incidence of resistance to gentamicin is on the rise. Bacterial isolates from 178 donor corneal rims were studied for gentamicin sensitivity. The overall rate of gentamicin resistance was 63.4%. At 86.2% the Pseudomonas. species had the highest rate of resistance, followed by Streptococci at 84.6%. The high rate of gentamicin resistance encountered by us and others suggest that either addition of a second antibiotic to corneal storage media or replacement of gentamicin by an antibiotic with a broader spectrum of activity may help reduce the risk of endophthalmitis following penetrating keratoplasty

Gopinathan Usha

1994-01-01

126

Infecção gonocócica em rim carcinomatoso Gonococcal infection in carcinomatous kidney  

Directory of Open Access Journals (Sweden)

Full Text Available Os A.A. observaram um caso de infecção renal gonocócica, que relatam com as necessarias minucias, tanto sob o ponto de vista clinico-cirurgico como bacteriologico. 2 - Revendo a bibliografia sobre o assunto, verificaram que as infecções renais gonocócias são raras, e rarissimas as que apresentam provas de identificação bacteriologica completa do gonocóco, como se fez no presente caso que deve figurar em 15º lugar, desde a descoberta do germen por Neisser, ha 59 anos. 3 - As provas bacteriologicas consistiram no exame bacterioscopico do sedimento urinario e pús renal, caracteres das colonias e culturas, seguidas de exames de esfregaços, provas de fermentação de glicose e maltose; sôro aglutinação e gono fixação. Todas as provas foram positivas para o gonocóco. 4- O rim não deve ser favoravel á proliferação do gonocóco, ou pela natureza do seu epitelio ou pela secreção de substancias que impeçam o seu desenvolvimento ou outra causa qualquer. Dada a frequencia das infecções gonocócicas no parelho urinario inferior, seria de esperar que, em grande numero de casos, fosse atingido o superior.5 - Como causas predisponentes a esse ataque secundario que se processa por vias sanguinea, linfatica ou contiguidade, cita Uhle as seguintes: 1º - perturbações congenitas, lesões obstrutoras, principalmente do ureter. 2º - calculos, tumores, etc. 3º - traumatismos seguidos de rutura e hemorragia e 4º - antecedentes patologícos não demonstrados. O nosso caso cabe no 2º paragrafo. O rim apresentava um tumor maligno e tinha inumeros calculos. 6 - Depois que o rim foi retirado pela intervenção cirurgica, que correu sem acidentes, o doente entrou logo a melhorar, tendo alta curado, do Hospital. Nada tem havido, até a presente data, que faça suspeitar, no desenvolvimento de qualquer metastase do tumor. Aliás, a operação foi indicada em virtude do estado infeccioso, sendo posterior á mesma a descoberta do carcinoma. 7 - Interessante referir tambem que, muito embora o rim estivesse atacado pelo gonocóco, o aparelho urinario inferior nada acusou nesse sentido, nem antes da operação, nem depois do doente ter tido alta. 8 - Casos como o presente, se bem que raros, pois que assim se têm mostrado nos centros onde a pesquiza é sistematica, devem aparecer outras vezes, sendo, portanto, sempre aconselhavel o exame bacteriologico dos casos de infecções renais supuradas.1 - The AA. observed a case of gonococcal infection of kidney which they report with the necessary details, both from the clinico-surgical and bacteriological standpoints. 2 - In perusing the bibliography on the matter, they verified that gonococcal infections of kidney are rare, and very rare those which present proofs of thorough bacteriological identification of the gonococcus, such as was furnished in the present case, which should occupy the 15th place since the discovery of the germ by Neisser, 59 years ago. 3 - In the bacterioscopical examination of the urinary sediment and of the pus from the kidney the bacteriological proofs are constituted by the characteristic features of the colonies and cultures, followed by examinations of the smears, by fermentation tests for glucose and maltose, by sero-agglutination and gono-fixation. All tests were positive for gonococcus. 4 - The kidney does not favour the proliferation of the gonococcus, either thanks to the nature of its epithelium, or thanks to the secretion of substances which prevent the development of the gonococcus, or thanks to any other cause. Taking into consideration the frequency of gonococcal infections of the lower urinary apparatus, it was to be expected that also the upper one should be attained in a great deal of cases. 5 - As to the causes which predispose to such a secondary attack proceeding by the way of blood, of lymphatic current or by contiguity, uhle quotes the following: 1º - Congenital disorders, obstruction changes, mainly of the ureter; 2º - Calculi, tumors, etc.; 3º - Traumatisms followed by rupture and hemorrhage; and 4º - Previ

Jorge de Gouvêa

1939-01-01

127

Infecção gonocócica em rim carcinomatoso / Gonococcal infection in carcinomatous kidney  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Os A.A. observaram um caso de infecção renal gonocócica, que relatam com as necessarias minucias, tanto sob o ponto de vista clinico-cirurgico como bacteriologico. 2 - Revendo a bibliografia sobre o assunto, verificaram que as infecções renais gonocócias são raras, e rarissimas as que apresentam pro [...] vas de identificação bacteriologica completa do gonocóco, como se fez no presente caso que deve figurar em 15º lugar, desde a descoberta do germen por Neisser, ha 59 anos. 3 - As provas bacteriologicas consistiram no exame bacterioscopico do sedimento urinario e pús renal, caracteres das colonias e culturas, seguidas de exames de esfregaços, provas de fermentação de glicose e maltose; sôro aglutinação e gono fixação. Todas as provas foram positivas para o gonocóco. 4- O rim não deve ser favoravel á proliferação do gonocóco, ou pela natureza do seu epitelio ou pela secreção de substancias que impeçam o seu desenvolvimento ou outra causa qualquer. Dada a frequencia das infecções gonocócicas no parelho urinario inferior, seria de esperar que, em grande numero de casos, fosse atingido o superior.5 - Como causas predisponentes a esse ataque secundario que se processa por vias sanguinea, linfatica ou contiguidade, cita Uhle as seguintes: 1º - perturbações congenitas, lesões obstrutoras, principalmente do ureter. 2º - calculos, tumores, etc. 3º - traumatismos seguidos de rutura e hemorragia e 4º - antecedentes patologícos não demonstrados. O nosso caso cabe no 2º paragrafo. O rim apresentava um tumor maligno e tinha inumeros calculos. 6 - Depois que o rim foi retirado pela intervenção cirurgica, que correu sem acidentes, o doente entrou logo a melhorar, tendo alta curado, do Hospital. Nada tem havido, até a presente data, que faça suspeitar, no desenvolvimento de qualquer metastase do tumor. Aliás, a operação foi indicada em virtude do estado infeccioso, sendo posterior á mesma a descoberta do carcinoma. 7 - Interessante referir tambem que, muito embora o rim estivesse atacado pelo gonocóco, o aparelho urinario inferior nada acusou nesse sentido, nem antes da operação, nem depois do doente ter tido alta. 8 - Casos como o presente, se bem que raros, pois que assim se têm mostrado nos centros onde a pesquiza é sistematica, devem aparecer outras vezes, sendo, portanto, sempre aconselhavel o exame bacteriologico dos casos de infecções renais supuradas. Abstract in english 1 - The AA. observed a case of gonococcal infection of kidney which they report with the necessary details, both from the clinico-surgical and bacteriological standpoints. 2 - In perusing the bibliography on the matter, they verified that gonococcal infections of kidney are rare, and very rare those [...] which present proofs of thorough bacteriological identification of the gonococcus, such as was furnished in the present case, which should occupy the 15th place since the discovery of the germ by Neisser, 59 years ago. 3 - In the bacterioscopical examination of the urinary sediment and of the pus from the kidney the bacteriological proofs are constituted by the characteristic features of the colonies and cultures, followed by examinations of the smears, by fermentation tests for glucose and maltose, by sero-agglutination and gono-fixation. All tests were positive for gonococcus. 4 - The kidney does not favour the proliferation of the gonococcus, either thanks to the nature of its epithelium, or thanks to the secretion of substances which prevent the development of the gonococcus, or thanks to any other cause. Taking into consideration the frequency of gonococcal infections of the lower urinary apparatus, it was to be expected that also the upper one should be attained in a great deal of cases. 5 - As to the causes which predispose to such a secondary attack proceeding by the way of blood, of lymphatic current or by contiguity, uhle quotes the following: 1º - Congenital disorders, obstruction changes, mainly of the ureter; 2º

Gouvêa, Jorge de; Lacorte, J. Guilherme.

128

New Science from New Technology: NanoSIMS and RIMS  

Science.gov (United States)

Introduction: Primitive meteorites and interplanetary dust particles (IDPs) contain small amounts (ppb-ppm) of nm- to ?m-sized presolar dust grains that formed in the winds of evolved stars or in the ejecta of stellar explosions. The first presolar minerals, diamond and silicon carbide (SiC), were found in 1987, followed by graphite, silicon nitride, and refractory oxides in the 1990s. Isotopic measurements on individual presolar grains, most of which were made by secondary ion mass spectrometry (SIMS), allowed to obtain a wealth of astrophysical information. Until the end of the last century, the isotope studies of individual grains were restricted to the light to intermediate-mass elements in grains > 1 ?m. The presolar grain research received a new push in recent years with the application of laser ablation and resonant ionization mass spectrometry (RIMS) and with the invention of the NanoSIMS ion microprobe. RIMS: This analysis technique has been successfully applied to measure the isotopic compositions of the heavy elements Sr, Zr, Mo, and Ba in individual, ?m-sized presolar SiC and graphite grains. These measurements have substantiated the view that the majority of presolar SiC originates from low-mass AGB stars and have provided detailed insights into neutron-capture reactions in AGB stars (s-process) and supernova explosions (neutron burst). NanoSIMS: The merit of the NanoSIMS is that it allows to extend isotopic studies to much smaller scales than was previously possible (< 100 nm compared to 1 ?m with conventional SIMS). This led to the identification of presolar silicate grains, first in IDPs and later also in primitive meteorites. Because also the majority of other presolar minerals are submicrometer in size, use of the NanoSIMS allows to access this important reservoir of presolar matter on a single grain basis. And, finally, isotopic heterogeneities within ?m-sized presolar SiC and graphite could be detected.

Hoppe, P.

2006-08-01

129

Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule.  

Science.gov (United States)

Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within various tissues in order to establish a human infection. We have identified the C. neoformans Rim101 transcription factor, a highly conserved pH-response regulator in many fungal species. The rim101 multiply sign in circle mutant strain displays growth defects similar to other fungal species in the presence of alkaline pH, increased salt concentrations, and iron limitation. However, the rim101 multiply sign in circle strain is also characterized by a striking defect in capsule, an important virulence-associated phenotype. This capsular defect is likely due to alterations in polysaccharide attachment to the cell surface, not in polysaccharide biosynthesis. In contrast to many other C. neoformans capsule-defective strains, the rim101 multiply sign in circle mutant is hypervirulent in animal models of cryptococcosis. Whereas Rim101 activation in other fungal species occurs through the conserved Rim pathway, we demonstrate that C. neoformans Rim101 is also activated by the cAMP/PKA pathway. We report here that C. neoformans uses PKA and the Rim pathway to regulate the localization, activation, and processing of the Rim101 transcription factor. We also demonstrate specific host-relevant activating conditions for Rim101 cleavage, showing that C. neoformans has co-opted conserved signaling pathways to respond to the specific niche within the infected host. These results establish a novel mechanism for Rim101 activation and the integration of two conserved signaling cascades in response to host environmental conditions. PMID:20174553

O'Meara, Teresa R; Norton, Diana; Price, Michael S; Hay, Christie; Clements, Meredith F; Nichols, Connie B; Alspaugh, J Andrew

2010-02-01

130

Anomalous linewidths and peak height ratios in continuous-wave RIMS  

International Nuclear Information System (INIS)

This paper describes effects of optical pumping in certain RIMS experiments. We show that anomalous peak height ratios and broadening effects can result from optically-induced redistribution of magnetic substate populations. We also show how lineshapes and peak heights in RIMS can be altered by branching to metastable electronic states. 6 refs., 5 figs., 1 tab

1986-09-07

131

Design and analytic evaluation of a rim effect reduction type LWR fuel for extending burnup  

International Nuclear Information System (INIS)

We have designed a new concept fuel design 'Rim effect reduction type fuel' which has thin natural UO2 layer on surface of a UO2 pellet. Our neutronic analyses with ANRB code show this fuel design can reduce rim effect (burnup at plelet rim) by about 30 GWd/t comparing a normal fuel. It is known that a high burnup fuel has different microstructure from as-fabricated one at fuel rim (which is called as rim region) due to rim effect. Therefore this fuel design can expect smaller rim region than a normal fuel. Our fuel performance analyses with EIMUS code show this fuel design can reduce fuel center temperature at high burnup if thermal conductivity of fuel pellet decreases with burnup in inverse proportion. However, this fuel design increases fuel center temperature at low and middle burnup than a normal fuel due to increase of thermal power density at pellet center. Additionally Irradiation experiment of this fuel design can be considered to offer important data which make clear the relation between rim effect and fuel performance. (author)

1991-01-01

132

The effect of vitamin A supplementation on retinoic acid-related orphan receptor ?t (ROR?t) and interleukin-17 (IL-17) gene expression in Avonex-treated multiple sclerotic patients.  

Science.gov (United States)

The aim of this study was to investigate the role of vitamin A on ROR?t and IL-17 gene expression in multiple sclerotic patients. Patients in the vitamin A group received 25,000 IU retinyl palmitate per day, while patients in the placebo group took one capsule of placebo per day for 6 months. Gene expression was measured by real-time PCR at the first and end of the study. The results of this study show that vitamin A downregulates IL-17 and ROR?t gene expression. No changes in gene expression occurred in the placebo group. PMID:23868508

Mohammadzadeh Honarvar, Niyaz; Harirchian, Mohammad Hossein; Koohdani, Fariba; Siassi, Feridoun; Abdolahi, Mina; Bitarafan, Sama; Salehi, Eisa; Sahraian, Mohammad Ali; Eshraghian, Mohammad Reza; Saboor-Yarghi, Ali Akbar

2013-11-01

133

49 CFR 571.110 - Tire selection and rims and motor home/recreation vehicle trailer load carrying capacity...  

Science.gov (United States)

... (2) âEâ indicates The European Tyre and Rim Technical Organization. (3...STRO). (7) âAâ indicates The Tyre and Rim Association of Australia. (8) âIâ indicates Indian Tyre Technical Advisory Committee...

2010-10-01

134

A SCUBA survey of bright-rimmed clouds  

CERN Multimedia

Context: Bright-rimmed clouds (BRCs) are potential examples of triggered star formation regions, in which photoionisation driven shocks caused by the expansion of HII regions induce protostellar collapse within the clouds. Aims: The main purpose of the paper is to establish the level of star formation occuring within a known set of BRCs. A secondary aim is to determine the extent, if any, to which this star formation has been promulgated by the process of photoionisation triggering. Methods:A primary set of observations is presented obtained with submillimeter SCUBA observations and archival data from near-IR and mid- to far-IR have been explored for relevant observations and incorporated where appropriate. Results:SCUBA observations show a total of 47 dense cores within the heads of 44 observed BRCs drawn from a catalogue of IRAS sources embedded within HII regions, supportive of the scenario proposed by RDI models. The physical properties of these cores indicate star formation across the majority of our sam...

Morgan, L K; Urquhart, J S; White, G J

2007-01-01

135

Human Rights in the Countries of the Southern Rim  

Directory of Open Access Journals (Sweden)

Full Text Available After practically all of the southern-rim countries of the Mediterranean gained their independence, the process of national construction has been predicated on authoritarian regimes. These regimes justified both the use of force against political opposition and the limits on rights and liberties on the need for maintaining the unanimity of the people which had manifested itself during the struggles for liberation from the colonial yoke. Towards the end of the 1980s, the regional and international context seemed to presage a very much longed for opening-up of the political scene after some of these countries (Tunisia, Algeria and Jordan initiated a series of movements that pointed to their democratisation. The posterior evolution of events has crushed those hopes in every case, and only Morocco and Jordan (each with their respective limitations appear to have evolved towards a softening of repression. The excuse put forth from the collection of states in the region to justify the step backwards is the existence of two threats they must act with forcefulness before: the threat of Islamic “fundamentalism” and the desire of certain groups to boycott the on-going Israeli-Palestinian Peace Process.

Laura Feliu i Martínez

1997-09-01

136

Soft tissue aneurysmal bone cyst  

Energy Technology Data Exchange (ETDEWEB)

A soft tissue aneurysmal bone cyst located in the right gluteus medius of a 21-year-old man is reported. On conventional radiography, the lesion demonstrated a spherically trabeculated mass with a calcific rim. On CT scan, it showed a well-organized peripheral calcification resembling a myositis ossificans. On MRI, it presented as a multilocular, cystic lesion with fluid-fluid levels. The lesion had no solid components except for intralesional septa. Although findings on imaging and histology were identical to those described in classical aneurysmal bone cyst, diagnosis was delayed because of lack of knowledge of this entity and its resemblance to the more familiar post-traumatic heterotopic ossification (myositis ossificans). (orig.)

Wang, X.L.; Gielen, J.L.; Delrue, F.; De Schepper, A.M.A. [Department of Radiology, Universitair Ziekenhuis Antwerpen (University of Antwerp), Wilrijkstraat 10, 2650, Edegem (Belgium); Salgado, R. [Department of Pathology, Universitair Ziekenhuis Antwerpen (University of Antwerp), Wilrijkstraat 10, 2650, Edegem (Belgium)

2004-08-01

137

The significance of echogenic rim of atypical hepatic hemangioma on ultrasonogram  

Energy Technology Data Exchange (ETDEWEB)

To evaluate whether the presence of a peripheral echogenic rim surrounding internal low echogenicity is helpful in the diagnosis of atypical hepatic hemangioma. Within a two-year period, a retrospective review of the sonographic appearances of 24 atypical hemangiomas in 21 patients was performed. Diagnosis was made by dynamic and delayed enhanced CT, MR imaging or clinical follow up for one year, including follow-up sonogram. The sonographic appearances of these hemangiomas were analyzed for pattern and thickness of the echogenic rim, internal echo pattern, shape, and size. Additionally, forty six lesions of hepatoma, metastasis, abscess and intrahepatic cholangiocarcinoma confirmed by pathology within the same period were also evaluated for the presence of echogenic rim. Twenty-three of 24 lesions showed an echogenic rim;these were thick in nine cases, and thin in 14 cases. The thickness of the rim was either uniform(n=10) or eccentric(n=13). The average maximum diameter of atypical hemangioma was 4.4cm(range of diameters, 1.5-12cm). The internal echo pattern was partially or entirely hypoechoic in 15 lesions, homogeneously isoechoic in three, and mixed in six cases. Twenty-one lesions were round, and the shape of three was irregular. The other forty six masses including hepatocellular carcinoma, metastases, cholangiocarcinoma and hepatic abscesses did not show an echogenic rim. The presence of a sonographic echogenic rim in a hepatic mass may help in the diagnosis of hepatic hemangioma.

Lee, Choon Hyeong; Ko, Young Tae; Lee, Dong Ho; Lim, Joo Won; Yoon, Yup [Kyunghee Univ. Hospital, Seoul (Korea, Republic of)

1996-11-01

138

The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host.  

Science.gov (United States)

The Rim101 protein is a conserved pH-responsive transcription factor that mediates important interactions between several fungal pathogens and the infected host. In the human fungal pathogen Cryptococcus neoformans, the Rim101 protein retains conserved functions to allow the microorganism to respond to changes in pH and other host stresses. This coordinated cellular response enables this fungus to effectively evade the host immune response. Preliminary studies suggest that this conserved transcription factor is uniquely regulated in C. neoformans both by the canonical pH-sensing pathway and by the cyclic AMP (cAMP)/protein kinase A (PKA) pathway. Here we present comparative transcriptional data that demonstrate a strong concordance between the downstream effectors of PKA and Rim101. To define Rim101-dependent gene expression during a murine lung infection, we used nanoString profiling of lung tissue infected with a wild-type or rim101? mutant strain. In this setting, we demonstrated that Rim101 controls the expression of multiple cell wall-biosynthetic genes, likely explaining the enhanced immunogenicity of the rim101? mutant. Despite its divergent upstream regulation, the C. neoformans Rim101 protein recognizes a conserved DNA binding motif. Using these data, we identified direct targets of this transcription factor, including genes involved in cell wall regulation. Therefore, the Rim101 protein directly controls cell wall changes required for the adaptation of C. neoformans to its host environment. Moreover, we propose that integration of the cAMP/PKA and pH-sensing pathways allows C. neoformans to respond to a broad range of host-specific signals. PMID:24324006

O'Meara, Teresa R; Xu, Wenjie; Selvig, Kyla M; O'Meara, Matthew J; Mitchell, Aaron P; Alspaugh, J Andrew

2014-02-01

139

{sup 18}F-FDG PET/CT bone/bone marrow findings in Hodgkin's lymphoma may circumvent the use of bone marrow trephine biopsy at diagnosis staging  

Energy Technology Data Exchange (ETDEWEB)

Accurate staging of Hodgkin's lymphoma (HL) is necessary in selecting appropriate treatment. Bone marrow trephine biopsy (BMB) is the standard procedure for depicting bone marrow involvement. BMB is invasive and explores a limited part of the bone marrow. {sup 18}F-FDG PET/CT is now widely used for assessing response to therapy in HL and a baseline study is obtained to improve accuracy. The aim of this retrospective analysis was to assess whether routine BMB remains necessary with concomitant {sup 18}F-FDG PET/CT. Data from 83 patients (newly diagnosed HL) were reviewed. All patients had received contrast-enhanced CT, BMB and {sup 18}F-FDG PET/CT. Results of BMB were not available at the time of {sup 18}F-FDG PET/CT imaging. Seven patients had lymphomatous involvement on BMB. Four patients had bone involvement on conventional CT (two with negative BMB). All patients with bone marrow and/or bone lesions at conventional staging were also diagnosed on {sup 18}F-FDG PET/CT scan. PET/CT depicted FDG-avid bone/bone marrow foci in nine additional patients. Four of them had only one or two foci, while the other had multiple foci. However, the iliac crest, site of the BMB, was not involved on {sup 18}F-FDG PET/CT. Osteolytic/sclerotic lesions matching FDG-avid foci were visible on the CT part of PET/CT in three patients. MRI ordered in three other patients suggested bone marrow involvement. Interim and/or end-therapy {sup 18}F-FDG PET/CT documented response of FDG-avid bone/bone marrow foci to chemotherapy in every patient. {sup 18}F-FDG PET/CT highly improves sensitivity for diagnosis of bone/bone marrow lesions in HL compared to conventional staging. (orig.)

Moulin-Romsee, Gerard [Universite Paris 7, Service de Medicine Nucleaire, Hopital Saint-Louis, Assistance Publique-Hopitaux de Paris (France); Institut Curie, Nuclear Medicine, Paris (France); Hindie, Elif; Filmont, Jean-Emmanuel; Moretti, Jean-Luc [Universite Paris 7, Service de Medicine Nucleaire, Hopital Saint-Louis, Assistance Publique-Hopitaux de Paris (France); Cuenca, Xavier; Brice, Pauline; Sibon, David [Hopital Saint-Louis, Haemato-Oncology, Paris (France); Decaudin, Didier; Anitei, Marcela [Institut Curie, Haematology, Paris (France); Benamor, Myriam [Institut Curie, Nuclear Medicine, Paris (France); Briere, Josette [Hopital Saint-Louis, Pathology, Paris (France); Kerviler, Eric de [Hopital Saint-Louis, Radiology, Paris (France)

2010-06-15

140

Crystal Structure of the RIM1? C2B Domain at 1.7 Å Resolution†,¶  

Digital Repository Infrastructure Vision for European Research (DRIVER)

RIM proteins play critical roles in synaptic vesicle priming and diverse forms of presynaptic plasticity. The C-terminal C2B domain is the only module that is common to all RIMs, but is only distantly related to well-studied C2 domains, and its three-dimensional structure and interactions have not been characterized in detail. Using NMR spectroscopy, we now show that N- and C-terminal extensions beyond the predicted C2B domain core sequence are necessary to form a folded, stable RIM1? C2B do...

Guan, Rong; Dai, Han; Tomchick, Diana R.; Dulubova, Irina; Machius, Mischa; Su?dhof, Thomas C.; Rizo, Josep

2007-01-01

 
 
 
 
141

Measurement of the wear of railway wheel-rims by radioisotopes  

International Nuclear Information System (INIS)

A relative measuring method based on the ratio of the activities of prepared railway wheel-rim surfaces before and after the wear test was developed and tested. In a 5 ?m thick plated layer "5"9Fe isotope was electrolitically deposited onto the rim surface. The relative decrease of the recorded intensities and the application of the Wickers-track technique provide a rapid and reliable method to measure the wear of railway wheel-rim under operation conditions. (Sz.J.)

1980-01-01

142

Oxygen isotopes in chondrules and coarse-grained chondrule rims from the Allende meteorite  

Science.gov (United States)

The relationship between the porphyritic chondrules and coase-grained chondrule rims of the Allende CV chondrite are examined. The oxygen isotopic compositions of seven chondrule-rim pairs and a large rimless refractory chondrule from Allende are determined. The results suggest that, to account for the O-isotopic compositions of the CV chondrules and rims, three solid precursor components are required: a high-temperature, refractory-, alkali, and (O-16)-rich component; a low-temperature, FeO-rich, refractory, and (O-16)-poor component, and an additional component to explain the composition of BO chondrules.

Rubin, Alan E.; Wasson, John T.; Clayton, Robert N.; Mayeda, Toshiko K.

1990-01-01

143

RIM, Munc13, and Rab3A interplay in acrosomal exocytosis  

Energy Technology Data Exchange (ETDEWEB)

Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM/Munc13/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM/Munc13/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking. -- Highlights: Black-Right-Pointing-Pointer RIM and Munc13 are present in human sperm and localize to the acrosomal region. Black-Right-Pointing-Pointer RIM and Munc13 are necessary for acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Munc13 participate before the acrosomal calcium efflux. Black-Right-Pointing-Pointer RIM, Munc13 and Rab3A interplay in human sperm acrosomal exocytosis. Black-Right-Pointing-Pointer RIM and Rab3A have critical roles in membrane docking.

Bello, Oscar D.; Zanetti, M. Natalia [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Mayorga, Luis S. [Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Michaut, Marcela A., E-mail: mmichaut@fcm.uncu.edu.ar [Laboratorio de Biologia Reproductiva, Instituto de Histologia y Embriologia, IHEM (CONICET-UNCuyo), Facultad de Ciencias Medicas (Argentina); Instituto de Ciencias Basicas, Universidad Nacional de Cuyo, Mendoza (5500) (Argentina)

2012-03-10

144

Secondary aneurysmal bone cystic change of the chondroblastoma, mistaken for a primary aneurysmal bone cyst in the patella.  

Science.gov (United States)

A 29-year-old woman complained of a 3-month history of left knee pain without trauma history. X-ray showed a well-defined osteolytic lesion with a sclerotic margin in the patella and magnetic resonance imaging showed T1-low and T2-high signal intensity with different fluid level. Our impression was an aneurysmal bone cyst. At surgery, the lesion was a blood-filled cystic cavity, surrounded by a gray or brownish tissue. Hemorrhagic soft tissues with recognizable bone fragments were observed. Curettage and autogenous bone graft was done. Microscopically, sheets of tumor cells were intermingled with some areas of eosinophilic chondroid matrix. The tumor cells showed oval-shaped nuclei with moderate eosinophilic cytoplasm. Several multinucleated giant cells and blood filled cystic cavities were observed. The final diagnosis was a chondroblastoma with a secondary aneurysmal bone cyst. At the post-operative 1.5-year follow-up, grafted bones were well incorporated radiographically and there were no recurrent evidence or any other abnormal symptoms. PMID:24639947

Chung, Jin Wha; Lee, Hwa Sung

2014-03-01

145

Secondary Aneurysmal Bone Cystic Change of the Chondroblastoma, Mistaken for a Primary Aneurysmal Bone Cyst in the Patella  

Science.gov (United States)

A 29-year-old woman complained of a 3-month history of left knee pain without trauma history. X-ray showed a well-defined osteolytic lesion with a sclerotic margin in the patella and magnetic resonance imaging showed T1-low and T2-high signal intensity with different fluid level. Our impression was an aneurysmal bone cyst. At surgery, the lesion was a blood-filled cystic cavity, surrounded by a gray or brownish tissue. Hemorrhagic soft tissues with recognizable bone fragments were observed. Curettage and autogenous bone graft was done. Microscopically, sheets of tumor cells were intermingled with some areas of eosinophilic chondroid matrix. The tumor cells showed oval-shaped nuclei with moderate eosinophilic cytoplasm. Several multinucleated giant cells and blood filled cystic cavities were observed. The final diagnosis was a chondroblastoma with a secondary aneurysmal bone cyst. At the post-operative 1.5-year follow-up, grafted bones were well incorporated radiographically and there were no recurrent evidence or any other abnormal symptoms.

Chung, Jin Wha

2014-01-01

146

Varied Mechanisms for Star Formation in Bright-Rimmed Clouds  

Science.gov (United States)

Bright-rimmed clouds (BRCs) are potential examples of triggered star-formation regions, in which photoionisation driven shocks caused by the expansion of HII regions induce protostellar collapse within the clouds. A sample of optically bright BRCs at the edge of HII regions has been observed at multiple wavelengths in order to investigate the possibility that star-formation is present. Such activity may be related to photoionisation induced shocks caused by the massive stars powering the HII regions. The sample has been observed at radio, infrared and submillimetre wavelengths, these observations reveal dense cores present within the heads of 44 observed BRCs drawn from a catalogue of IRAS sources embedded within HII regions, supportive of the scenario proposed by radiatively driven implosion (RDI) models. The physical properties of these cores indicate the presence of star formation across the majority of our sample. This star-formation appears to be predominately in the regime of intermediate to high mass and may indicate the formation of clusters. IR observations indicate the association of early star forming sources with the sample. A fundamental difference appears to exist between different morphological types of BRC. Morphological variations in BRCs have previously been attributed to an evolutionary scenario of RDI. However, the physical properties of cores found within different types of BRC indicate that the strength of the ambient ionisation field is highly correlated with the attributes of certain cores, and not with others. The suggestion is that different morphological types of BRC have followed different evolutionary pathways, this is supported by the mass distributions of cores associated with the different morphologies.

Morgan, Larry; Urquhart, J.; Thompson, M.; White, G.; Figura, C.

2007-12-01

147

ENGINEERING APPROACH TO CALCULATION OF HEAT-SHIELDING CHARACTERISTICS FOR CONSTRUCTIONS WITH RIM ZONES / ?????????? ?????? ? ??????? ????????????? ????????????? ???????????? ??????????? ? ???????? ??????  

Directory of Open Access Journals (Sweden)

Full Text Available It is shown that the developed by the authors method of calculation of three-dimensional temperature fields gives great opportunities for the engineering assessment of heat-shielding characteristics for constructions with rim zones / ????????, ??? ????????????? ??????? ????????? ?????? ????? ??????? ?????????? ????????????? ????? ????????? ??????? ??????????? ??? ?????????? ?????? ????????????? ????????????? ???????????? ??????????? ? ???????? ??????

Kornienko Sergey Valerevich / ????????? ?????? ??????????

2014-03-01

148

Reaction rim growth on olivine in silicic melts: Implications for magma mixing  

Science.gov (United States)

Finely crystalline amphibole or pyroxene rims that form during reaction between silicic host melt and cognate olivine xenocrysts, newly introduced during magma mixing events, can provide information about the timing between mixing and volcanic eruptions. We investigated rim growth experimentally by placing forsteritic olivine in rhyolitic and rhyodacitic melts for times between 25 and 622 h at 50 and 150 MPa, H2O-saturated, at the Ni-NiO buffer. Rims of orthopyroxene microlites formed from high-silica rhyolite and rhyodacite melts at 885??C and 50 MPa, and in the rhyolite at 150 MPa and 885??C. Rims of amphibole with lesser orthopyroxene formed in the rhyolite at 150 MPa and 800??C and in the rhyodacite at 150 MPa and 885??C. Irregular, convolute olivine edges and mass balance between olivine, melt, and rim phases show that olivine partly dissolved at all conditions. Iron-rich zones at the exteriors of olivines, which increased in width parabolically with time, show that Fe-Mg interdiffusion occurring in olivines was not outpaced by olivine dissolution. Linear increases of the square of rim widths with time suggest that diffusion within the melt is the rate-controlling process for olivine dissolution and rim growth. Rims grew one-half to one order-of-magnitude faster when melt water contents were doubled, unless conditions were far above the liquidus. Rim growth rate in rhyolite increases from 0.055 ?? 0.01 ??m2/h at 885 ??C and 50 MPa to 0.64 ?? 0.13 ??m2/h at 800 ??C and 150 MPa. Melt composition has a lesser effect on rim growth rates, with growth rate increasing as melt SiO2 content decreases. Pyroxene rims on olivines in andesite erupted from Arenal volcano (Costa Rica) grew at a rate of 3.0 ?? 0.2 ??m2/h over an eleven-year period. This rate is faster than those of the experiments due to lower melt viscosity and higher temperatures, and suggests that a magma mixing event preceded the start of the eruption by days.

Coombs, M. L.; Gardner, J. E.

2004-01-01

149

Resurfacing monoblock of steel R7T wheel rims (MBW for the train wagons  

Directory of Open Access Journals (Sweden)

Full Text Available The steel R7T monoblock wheel material properties are defined by the International Declaration UIC 812-3. Taking into consideration the resurfacing of the rim, the analyzed conditions for the resurfacing, as well as the analysis of the chemical compounds, mechanical characteristics (material hardness, pulling strength, and tenacity, ultrasound and metallographic testing, which proved that the resurfaced rim area has the required characteristics, according to the Declaration UIC 812-3.

V. Vukovi?

2011-04-01

150

Metallurgical analysis of rim cracking in an lp steam turbine disc  

International Nuclear Information System (INIS)

An investigation of the nature of in-service cracking in LP turbine rotors encountered in a PWR nuclear power plant was performed. The investigation was based on a metallurgical evaluation of disc rim samples from one of the two rotors involved. The program included a detailed magnetic particle inspection of the rim samples, in-depth metallographic and fractographic examinations of cracked blade attachment steeples and chemical analyses of the disc material

1980-01-01

151

Application of RIMS to the study of noble gases in meteorites  

International Nuclear Information System (INIS)

The paper examines the possibility of using Resonance Ionization Multiphoton Spectroscopy (RIMS) for individual atom counting of noble gases in meteorites. A description is given of the techniques to extract the gases from the meteorites, as well as the noble gas components. Application of RIMS to meteoritic noble gases is discussed with respect to: sample weights required for analysis, problems of adsorbed atomospheric gases on the samples, and the sensitivity of the spectrometer. (U.K.)

1986-01-01

152

RIM Promotes Calcium Channel Accumulation at Active Zones of the Drosophila Neuromuscular Junction  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Synaptic communication requires the controlled release of synaptic vesicles from presynaptic axon terminals. Release efficacy is regulated by the many proteins that comprise the presynaptic release apparatus, including Ca2+ channels and proteins that influence Ca2+ channel accumulation at release sites. Here we identify Drosophila RIM and demonstrate that it localizes to active zones at the larval neuromuscular junction. In Drosophila RIM mutants, there is a large decrease in evoked synaptic ...

Graf, Ethan R.; Valakh, Vera; Wright, Christina M.; Wu, Chunlai; Liu, Zhihua; Zhang, Yong Q.; Diantonio, Aaron

2012-01-01

153

Magnetic-Field Amplification in the Thin X-ray Rims of SN1006  

CERN Document Server

Several young supernova remnants (SNRs), including SN1006, emit synchrotron X-rays in narrow filaments, hereafter thin rims, along their periphery. The widths of these rims imply 50 to $100 \\mu$G fields in the region immediately behind the shock, far larger than expected for the interstellar medium compressed by unmodified shocks, assuming electron radiative losses limit rim widths. However, magnetic-field damping could also produce thin rims. Here we review the literature on rim width calculations, summarizing the case for magnetic-field amplification. We extend these calculations to include an arbitrary power-law dependence of the diffusion coefficient on energy, $D \\propto E^{\\mu}$. Loss-limited rim widths should shrink with increasing photon energy, while magnetic-damping models predict widths almost independent of photon energy. We use these results to analyze Chandra observations of SN 1006, in particular the southwest limb. We parameterize the full widths at half maximum (FWHM) in terms of energy as FW...

Ressler, Sean M; Reynolds, Stephen P; Long, Knox S; Petre, Robert; Williams, Brian J; Winkler, P Frank

2014-01-01

154

Experimental investigation of the nebular formation of chondrule rims and the formation of chondrite parent bodies  

CERN Document Server

We developed an experimental setup to test the hypothesis that accretionary dust rims around chondrules formed in the solar nebula at elevated temperatures. Our experimental method allows us to form dust rims around chondrule-analogs while being levitated in an inert-gas flow. We used micrometer-sized powdered San Carlos olivine to accrete individual dust particles onto the chondrule-analog at a temperature of 1100{\\deg}C. The resulting dust-rims were analyzed by means of two different techniques: one sample was investigated with non-destructive micro computer tomography, the other with a scanning electron microscope. Both methods give very similar results for the dust-rim structure and a mean dust-rim porosity of 60 percent, demonstrating that both methods are equally well suited for sample analysis. The chondrule-analog's bulk composition has no measurable effect on the accretion efficiency of the dust. We measured the chemical composition of chondrule-analog and dust-rim to check whether elemental exchange...

Beitz, Eike; Mathieu, Romain; Pack, Andreas; Hezel, Dominik C

2011-01-01

155

Analysis of rim effect in high burnup (U, Gd)O2 fuel  

International Nuclear Information System (INIS)

Extending burnup of LWR fuel is efficient to reduce the fuel cycle cost and the number of spent fuels. Gadolinia will be mixed in LWR fuels to control the initial reactivity of the high burnup assembly because gadolinia is one of the good burnable poisons of neutron. Rim effect in (U,Gd)O2 fuel was analyzed by the detailed burnup analysis code VIMBURN. The rim effect in (U,Gd)O2 is more significant than that in UO2 fuel below 20 MWd/kgU and the difference of the rim effects in both fuels decreases as burnup proceeds above 20 MWd/kgU. The rim effects in (U,Gd)O2 and UO2 fuels are in the same level at high burnup of 80 MWd/kgU when the rim structure forms. The burnup rate of (U,Gd)O2 rod is less than that of UO2 rods surrounding the (U,Gd)O2 rod in the assembly due to neutron absorption of gadolinium. Accordingly local burnup at the peripheral region in (U,Gd)O2 fuel reaches the high burnup of 80 MWd/kgU a little after the local burnup in UO2 fuel does. Therefore, it can be predicted that the impact of rim structure on the fuel behaviour in (U,Gd)O2 fuel is as much as in UO2 fuel at high burnup of the assembly. (author)

1992-11-01

156

CT Guided Bone Biopsy Using a Battery Powered Intraosseous Device  

Energy Technology Data Exchange (ETDEWEB)

Purpose: To evaluate the feasibility of a battery powered intraosseous device to perform CT-fluoroscopy guided bone biopsy. Methods: Retrospective analysis of 12 patients in whom bone specimen were acquired from different locations under CT-fluoroscopy guidance using the OnControl bone marrow biopsy system (OBM, Vidacare, Shavano Park, TX, USA). Data of the 12 were compared to a historic cohort in whom the specimen were acquired using the classic Jamshidi Needle, as reference needle using manual force for biopsy. Results: Technical success was reached in 11 of 12 cases, indicated by central localisation of the needle within the target lesion. All specimen sampled were sufficient for histopathological workup. Compared to the historical cohort the time needed for biopsy decreased significantly from 13 {+-} 6 to 6 {+-} 4 min (P = 0.0001). Due to the shortened intervention time the radiation dose (CTDI) during CT-fluoroscopy was lowered significantly from 169 {+-} 87 to 111 {+-} 54 mGy Multiplication-Sign cm (P = 0.0001). Interventional radiologists were confident with the performance of the needle especially when using in sclerotic or osteoblastic lesions. Conclusion: The OBM is an attractive support for CT-fluoroscopy guided bone biopsy which is safe tool and compared to the classical approach using the Jamshidi needle leading to significantly reduced intervention time and radiation exposure.

Schnapauff, Dirk, E-mail: dirk.schnapauff@charite.de; Marnitz, Tim, E-mail: tim.marnitz@charite.de; Freyhardt, Patrick, E-mail: Patrick.freyhardt@charite.de; Collettini, Federico, E-mail: Federico.collettini@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany); Hartwig, Kerstin, E-mail: kerstin.hartwig@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Haematology and Oncology (Germany); Joehrens, Korinna, E-mail: korinna.joehrens@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Pathology (Germany); Hamm, Bernd, E-mail: bernd.hamm@charite.de; Kroencke, Thomas, E-mail: thomas.kroencke@charite.de; Gebauer, Bernhard, E-mail: Bernhard.gebauer@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany)

2013-10-15

157

CT Guided Bone Biopsy Using a Battery Powered Intraosseous Device  

International Nuclear Information System (INIS)

Purpose: To evaluate the feasibility of a battery powered intraosseous device to perform CT-fluoroscopy guided bone biopsy. Methods: Retrospective analysis of 12 patients in whom bone specimen were acquired from different locations under CT-fluoroscopy guidance using the OnControl bone marrow biopsy system (OBM, Vidacare, Shavano Park, TX, USA). Data of the 12 were compared to a historic cohort in whom the specimen were acquired using the classic Jamshidi Needle, as reference needle using manual force for biopsy. Results: Technical success was reached in 11 of 12 cases, indicated by central localisation of the needle within the target lesion. All specimen sampled were sufficient for histopathological workup. Compared to the historical cohort the time needed for biopsy decreased significantly from 13 ± 6 to 6 ± 4 min (P = 0.0001). Due to the shortened intervention time the radiation dose (CTDI) during CT-fluoroscopy was lowered significantly from 169 ± 87 to 111 ± 54 mGy × cm (P = 0.0001). Interventional radiologists were confident with the performance of the needle especially when using in sclerotic or osteoblastic lesions. Conclusion: The OBM is an attractive support for CT-fluoroscopy guided bone biopsy which is safe tool and compared to the classical approach using the Jamshidi needle leading to significantly reduced intervention time and radiation exposure

2013-10-01

158

Bone metastases as the presenting manifestation of rhabdomyosarcoma in childhood  

International Nuclear Information System (INIS)

Rarely, rhabdomyosarcoma can present with bone pain and bone lesions on radiographs without evidence of a primary tumor. Of 428 children with biopsy-proven rhabdomyosarcoma, four presented with radiographic evidence of bone metastases, but no primary tumor was found on subsequent evaluation. On radiographs, these metastases, located most commonly in the metaphyses of the extremities and in the spine, displayed a destructive or diffusely permeative pattern without sclerotic margins and mimicked the more common neuroblastoma. One patient also had diaphyseal cortical lytic metastases of the tibia. Radiographs defined metastases of the extremities better than the correlative bone scans. In the spine, on T2-weighted magnetic resonance (MR) images, metastases displayed high signal intensity which contrasted with the low-signal-intensity marrow in these pediatric patients. On histopathologic examination, metastatic rhabdomyosarcoma was composed of small cells of variable size, shape, and growth pattern similar to other round cell tumors. A positive desmin immunohistochemical test helped to establish the diagnosis. The radiologist, pathologist, and clinician should be aware of this unusual presentation of rhabdomyosarcoma so that suitable immunohistochemical tests are performed and appropriate chemotherapy given. (orig.)

1993-08-01

159

Bone Markers  

Science.gov (United States)

... Remodeling Related tests: Calcium , Phosphorus , Vitamin D , PTH , ALP At a Glance Test Sample The Test Common ... acid phosphatase (TRAP) 5b Bone-specific alkaline phosphatase (ALP) Osteocalcin (bone gla protein) For further discussion of ...

160

Bone Densitometry  

Medline Plus

Full Text Available ... well as bed rest, weakens the bones. A diet low in dairy products and calcium can make ... with oral medication, staying active and a healthy diet. Bone density tests are available and very helpful ...

 
 
 
 
161

Bone Densitometry  

Medline Plus

Full Text Available X-Plain Bone Densitometry Reference Summary Introduction Bone densitometry is a helpful radiological test for detecting the early stages of osteoporosis, before any symptoms occur. ...

162

99mTc MDP bone scan in evaluation of painful scoliosis  

International Nuclear Information System (INIS)

A 18-year-old male presented with low back ache. The patient was investigated and was diagnosed to have painful scoliosis. X-ray and other examinations could not reveal any diagnosis. The patient was referred to undergo bone scan on clinical suspicion of osteoid osteoma and to rule out stress fracture if any. Planar bone scan was performed, which showed a lesion in L3 vertebra and was further evaluated with SPECT (Single photon emission computed tomography) study to characterize the lesion. On SPECT examination, the classical features of osteoid osteoma, the double density sign (11), was noted in the pars interarticularis region. These findings were confirmed by a CT scan, which showed a sclerotic lesion in pars interarticularis of L3 vertebra. The patient was posted for operation and was relieved of symptoms in the postoperative follow-up. (author)

2010-01-01

163

Computed tomography of temporal bone pneumatization. 1. Normal pattern and morphology  

Energy Technology Data Exchange (ETDEWEB)

The pneumatization of 141 normal temporal bones on computed tomography (CT) was evaluated in 100 patients. Because of the controversy surrounding the sclerotic squamomastoid (mastoid), temporal bones with this finding were discarded. A CT index of pneumatization was based on the pneumatized area and the number of cells seen within a representative scanning section. Results suggest that squamomastoid pneumatization follows the classic normal distribution and does not correlate with age, gender, or laterality. A high degree of symmetry was found in 41 patients who had both ears examined. Air-cell configuration was variable. Air-cell size tended to increase progressively from the mastoid antrum. The scutum pseudotumor appearance caused by incomplete pneumatization was seen frequently, and should not be mistaken for mastoiditis or an osteoma. Thick sections producing partial-volume effect may also produce this spurious finding. Therefore, when searching for mucosal thickening due to mastoiditis, large air cells should preferably be analyzed.

Virapongse, C.; Sarwar, M.; Bhimani, S.; Sasaki, C.; Shapiro, R.

1985-09-01

164

Characterizing Pyroxene Reaction Space in Calcium-Aluminum Rich Inclusions: Oxidation During CAI Rim Formation  

Science.gov (United States)

We define the reaction space that controls changes in pyroxene composition in CAIs and Wark-Lovering (WL) rims in an oxidizing solar nebula. Ti-rich pyroxenes in CAIs record a sub-solar oxygen fugacity (Ti3+/Ti4+~1.5). WL rim pyroxenes in the CAI Leoville 144A have a distinctly lower oxidation state.This difference supports WL rim condensation in an environment of increasing O2(g) and Mg(g) (Simon et al. 2005). We used the following phase components to identify four linearly independent reactions (Thompson 1982): diopside, CaTs (Al2Mg-1Si-1), T3 (Ti3+AlMg-1Si-1), T4 (Ti4+Al2Mg-1Si-2), En (MgCa-1), perovskite, O(g), Mg(g), SiO(g), and Ca(g). Compositional variation in this system is dominated by two reactions. The first is oxidation of Ti3+ via reaction with O and Mg in the gas phase: 1.5 O(g) + Mg(g) ? ¼ Di + [Ti4+Mg3/4Ti3+-1Ca-1/4Si-1/2] (1). Pyroxene is produced and En is introduced. The second reaction (2) is perovskite formation. It is observed in the WL rim of Leoville 144A, and experiments confirm that an elevated Ti component converts pyroxene to perovskite(Gupta et al. 1973). MgCa-1 is the third linearly independent reaction (3). They combine to give: ½ Di + x Ca(g)? x Mg(g)+ Pv + [Mg1/2-xSiTi4+-1Ca-1/2+x](2,3). Unlike (1), pyroxene is consumed in this reaction. The parameter x defines the extent of Mg-Ca exchange. When x > 0.5, WL rim formation occurs in an environment where Mg is volatile and Ca condenses. The reaction space defined by reactions (1) and (2,3) describes the transition from CAI interior to WL rims. WL rim pyroxene Ti contents, [CaTs], and Ca reduction forms Ti4+, releasing SiO(g). (4) does not describe the oxidation of Ti3+ in WL rim pyroxene, but (1) - (4) results in En formation directly from the gas phase. This may explain WL rim analyses that have Si contents in excess of those predicted from reactions (1) and (2,3). Simon et al. (2005) EPSL 41, 272-283; Thompson (1982)Rev. Min. 10, 33-52; Gupta et al. (1973) Contr. Mineral. Petrol. 41, 333-344 Reaction space for CAI pyroxene. Pyroxenes plotted using titanium contents.

Dyl, K. A.; Young, E. D.

2009-12-01

165

Acetabular rim and surface segmentation for hip surgery planning and dysplasia evaluation  

Science.gov (United States)

Knowledge of the acetabular rim and surface can be invaluable for hip surgery planning and dysplasia evaluation. The acetabular rim can also be used as a landmark for registration purposes. At the present time acetabular features are mostly extracted manually at great cost of time and human labor. Using a recent level set algorithm that can evolve on the surface of a 3D object represented by a triangular mesh we automatically extracted rims and surfaces of acetabulae. The level set is guided by curvature features on the mesh. It can segment portions of a surface that are bounded by a line of extremal curvature (ridgeline or crestline). The rim of the acetabulum is such an extremal curvature line. Our material consists of eight hemi-pelvis surfaces. The algorithm is initiated by putting a small circle (level set seed) at the center of the acetabular surface. Because this surface distinctively has the form of a cup we were able to use the Shape Index feature to automatically extract an approximate center. The circle then expands and deforms so as to take the shape of the acetabular rim. The results were visually inspected. Only minor errors were detected. The algorithm also proved to be robust. Seed placement was satisfactory for the eight hemi-pelvis surfaces without changing any parameters. For the level set evolution we were able to use a single set of parameters for seven out of eight surfaces.

Tan, Sovira; Yao, Jianhua; Yao, Lawrence; Summers, Ronald M.; Ward, Michael M.

2008-04-01

166

Impact of slippage on the morphology and stability of a dewetting rim  

Energy Technology Data Exchange (ETDEWEB)

In this study lubrication theory is used to describe the stability and morphology of the rim that forms as a thin polymer film dewets from a hydrophobized silicon wafer. Thin film equations are derived from the governing hydrodynamic equations for the polymer to enable the systematic mathematical and numerical analysis of the properties of the solutions for different regimes of slippage and for a range of timescales. Dewetting rates and the cross sectional profiles of the evolving rims are derived for these models and compared to experimental results. Experiments also show that the rim is typically unstable in the spanwise direction and develops thicker and thinner parts that may grow into 'fingers'. Linear stability analysis as well as nonlinear numerical solutions are presented to investigate shape and growth rate of the rim instability. It is demonstrated that the difference in morphology and the rate at which the instability develops can be directly attributed to the magnitude of slippage. Finally, a derivation is given for the dominant wavelength of the bulges along the unstable rim.

Muench, Andreas [Mathematical Institute, University of Oxford, Oxford (United Kingdom); Wagner, Barbara, E-mail: wagnerb@wias-berlin.de [Weierstass Institute, Mohrenstrasse 39, 10117 Berlin (Germany)

2011-05-11

167

Impact of slippage on the morphology and stability of a dewetting rim  

International Nuclear Information System (INIS)

In this study lubrication theory is used to describe the stability and morphology of the rim that forms as a thin polymer film dewets from a hydrophobized silicon wafer. Thin film equations are derived from the governing hydrodynamic equations for the polymer to enable the systematic mathematical and numerical analysis of the properties of the solutions for different regimes of slippage and for a range of timescales. Dewetting rates and the cross sectional profiles of the evolving rims are derived for these models and compared to experimental results. Experiments also show that the rim is typically unstable in the spanwise direction and develops thicker and thinner parts that may grow into 'fingers'. Linear stability analysis as well as nonlinear numerical solutions are presented to investigate shape and growth rate of the rim instability. It is demonstrated that the difference in morphology and the rate at which the instability develops can be directly attributed to the magnitude of slippage. Finally, a derivation is given for the dominant wavelength of the bulges along the unstable rim.

2011-05-11

168

Cratering motions and structural deformation in the rim of the Prairie Flat multiring explosion crater  

Science.gov (United States)

Cratering motions and structural deformation are described for the rim of the Prairie Flat multiring crater, 85.5 m across and 5.3 m deep, which was formed by the detonation of a 500-ton TNT surface-tangent sphere. The terminal displacement and motion data are derived from marker cans and velocity gages emplaced in drill holes in a three-dimensional matrix radial to the crater. The integration of this data with a detailed geologic cross section, mapped from deep trench excavations through the rim, provides a composite view of the general sequence of motions that formed a transiently uplifted rim, overturned flap, inverted stratigraphy, downfolded rim, and deformed strata in the crater walls. Preliminary comparisons with laboratory experimental cratering and with numerical simulations indicate that explosion craters of the Prairie Flat-type generated by surface and near-surface energy sources tend to follow predictable motion sequences and produce comparable structural deformation. More specifically, central uplift and multiring impact craters with morphologies and structures comparable to Prairie Flat are inferred to have experienced similar deformational histories of the rim, such as uplift, overturning, terracing, and downfolding.

Roddy, D. J.; Ullrich, G. W.; Sauer, F. M.; Jones, G. H. S.

1977-01-01

169

Modelling of Rim-layer features in frames of START-3 code development  

International Nuclear Information System (INIS)

'Rim-effect' is a conventional term implying a number of microstructure and thermal physical phenomena, oriented from the periphery of a highly irradiated LWR fuel pellet, also called 'rim layer', 'rim', 'high burnup structure' (HBS) etc. One of the rim-effect consequences, important for fuel reliability, is evident intensification of fission gas release (FGR) and increase of rod internal pressure after certain threshold of fuel burnup. Results from post irradiation examinations (PIE) of WWER fuel demonstrate this tendency in a range of rod average burnup from 42-45 MWd/kgU to 60-65 Mwd/kgU. A recently developed dynamic model of FGR behavior based on analysis of a number of interrelated microstructure processes, differing by their rates and magnitudes and depending on external operational conditions, is briefly described in this paper. A verification of the model is performed using experimental data on matrix xenon EPMA and on fuel porosity. The verified model is integrated in the START-3 code and full-scale calculations of FGR are performed with the code. The developed model has demonstrated a good prediction for some important parameter of rim microstructure and for values of integral fission gas release in highly irradiated WWER fuel rods

2001-10-01

170

Hypoechoic rim of chronically inflamed prostate, as seen at TRUS: histopathologic findings  

International Nuclear Information System (INIS)

The purpose of this study is to correlate the findings of peripheral hypoechoic rim, seen at transrectal ultrasonography (TRUS) in chronic prostatitis patients, with the histopthologic findings. Seven patients with pathologically proven chronic prostatitis were involved in this study. The conspicuity of the peripheral hypoechoic prostatic rim, seen at TRUS, was prominent and subtle, and to determine its histopathologic nature, the microscopic findings were reviewed. In five of seven cases (71%), TRUS demonstrated a prominent peripheral hypoechoic rim. Microscopic examination revealed that inflammatory cell infiltration of prostatic glandular tissue was severe in three cases (42.9%), moderate in two (28.6%), and minimal in two (28.6%). In all seven cases, the common histopathologic findings of peripheral hypoechoic rim on TRUS were loose stromal tissues, few prostatic glands, and sparse infiltration by inflammatory cells. The peripheral hypoechoic rim accompanying prostatic inflammation and revealed by TRUS reflects a sparsity of prostate glandular tissue and is thought to be an area in which inflammatory cell infiltration is minimal

2001-09-01

171

Hypoechoic rim of chronically inflamed prostate, as seen at TRUS: histopathologic findings  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study is to correlate the findings of peripheral hypoechoic rim, seen at transrectal ultrasonography (TRUS) in chronic prostatitis patients, with the histopthologic findings. Seven patients with pathologically proven chronic prostatitis were involved in this study. The conspicuity of the peripheral hypoechoic prostatic rim, seen at TRUS, was prominent and subtle, and to determine its histopathologic nature, the microscopic findings were reviewed. In five of seven cases (71%), TRUS demonstrated a prominent peripheral hypoechoic rim. Microscopic examination revealed that inflammatory cell infiltration of prostatic glandular tissue was severe in three cases (42.9%), moderate in two (28.6%), and minimal in two (28.6%). In all seven cases, the common histopathologic findings of peripheral hypoechoic rim on TRUS were loose stromal tissues, few prostatic glands, and sparse infiltration by inflammatory cells. The peripheral hypoechoic rim accompanying prostatic inflammation and revealed by TRUS reflects a sparsity of prostate glandular tissue and is thought to be an area in which inflammatory cell infiltration is minimal.

Lee, Hak Jong [Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Choe, Ghee Young; Kim, Seung Hyup [Seoul National University College of Medicine, Seoul (Korea, Republic of); Seong, Chang Gyu [Kyungpook National University College of Medicine, Taegu (Korea, Republic of)

2001-09-01

172

Rim current and coastal eddy mechanisms in an eddy-resolving Black Sea general circulation model  

Science.gov (United States)

The DieCAST ocean model is applied to a study of the circulation in the Black Sea, using 1/12° horizontal resolution and with 20 vertical layers. Boundary forcings are monthly wind stress, evaporation minus precipitation, air-sea heat flux, freshwater influx from 11 rivers and exchange with the Mediterranean Sea through the Bosphorus Strait. The model reproduces fundamental physical features of the Black Sea: seasonal fluctuations in the quasi-permanent cyclonic Rim Current, numerous anticyclonic meanders and eddies lying between the Rim Current and the coast, Rossby waves propagating westward across the basin, coastally trapped waves, and the annual cycle of vertical mixing. Model results shed light on the mechanisms affecting such features. These include interactions of the Rim Current with coastal bathymetry abutments, leading to recirculations that pinch off vortices as in island wakes, and possible baroclinic instability of the Rim Current; these are modulated by the large annual stratification cycle above a relatively shallow and strong pycnocline, as is the Rim Current itself. The resulting wake eddies often merge into major coastal circulation features such as the seasonal Batumi and Sevastopol eddies. These anticyclonic eddies play a fundamental role in coastal and open-sea exchange processes. Hydrographic data from sampling cruises and recent Topex-Poseiden (T/P) altimeter data strongly supports our analysis.

Staneva, Joanna V.; Dietrich, David E.; Stanev, Emil V.; Bowman, Malcolm J.

2001-11-01

173

Mechanical fracture study of nuclear fuel high burn-up structure (HBS or RIM) during annealing test; Etude de la fracturation mecanique de la structure a haut taux de combustion des combustibles irradies (RIM) en traitement thermique  

Energy Technology Data Exchange (ETDEWEB)

The ceramics used in Power Water Reactors ar made of uranium dioxide. Irradiated at high Burn-up, they present a characteristic zone in periphery called High Burn-Up Structure or RIM zone with micrometer pores containing over-pressurized gas bubbles. Annealing texts simulating incidental or accidental reactor situations, a strong release of the RIM zone is observed. We have considered that the fission gas release mechanism is the mechanical fracture of the RIM grain boundaries. The we have compared the different types of mechanical stress applied to a grain boundary with the fracture stress of the oxide. The first stress is due to RIM over-pressurized gas bubbles, these bubbles apply a stress field determined at a microscopic level i.e. at the gas bubbles scale and its local environment. The second stress is generated by the Pellet-Cladding Mechanical Interaction (PCMI). This stress applies a stress field on a microscopic scale i.e. at the RIM zone and its overall environment. The last stress is occurred by a strain due to the RIM structural evolution during annealing test. The experimental results show that microscopic and macroscopic stress fields to do not explain the RIM grain boundary fracture during annealing test. The stresses induced by the RIM structural evolution as a function of the temperature is a possible mechanism to explain the overall mechanical behavior of the RIM zone during annealing test. (author)

Marcet, M.

2010-12-07

174

Development of phased array UT technique for inspection of turbine wheel rim  

International Nuclear Information System (INIS)

A phased array UT technique has been developed for the improvement of defect detection under the keyway region of shrunk-on type turbine wheel. The sector scanning mode operation with plexiglas wedge of phased array capability was applied to construct the B-scope image of turbine wheel rim region. Preceding to the inspection test of the model specimen having real shape of rim region, the distribution of sound field intensity along the steering angle of the scanning line was measured on the test block. Then, the minimum depth of detectable defect by the B-scope imaging was evaluated on the dovetail shape specimens which had different depth EDM notches at the each hook fillet. As the results, it has been realized that the B-scope imaging of the sector scanning mode phased array technique has a capability for distinguishing the defect echoes from the many reflection echoes caused by the complexed shape of wheel rim region

1986-11-17

175

Development of a New Resilience Scale: The Resilience in Midlife Scale (RIM Scale  

Directory of Open Access Journals (Sweden)

Full Text Available Resilience, the ability to maintain or regain positive levels of functioning despite adversity, is one of several strengths that can assist people in positive life adaptation. Midlife (35 - 60 years is a period when individuals need to adapt to several major changes and challenges. However, no scale exists to measure resilience specifically in the midlife population. Therefore, this study develops a new scale to measure resilience in midlife. The RIM scale consists of 25 items, each self-rated on a 5-point scale (0-4, with higher scores reflecting greater resilience. The scale was administered to a sample of 130 men and women, aged 35 - 60 years, from the normal population. The reliability, validity and factor analytic structure of the scale were evaluated, and reference scores established. The RIM scale demonstrated sound psychometric properties and factor analysis yielded five factors. The RIM scale has potential utility in clinical and research settings.

Linda Ryan

2009-10-01

176

Cracking of an Aircraft Wheel Rim Made From Al-Alloy 2014-T6  

Directory of Open Access Journals (Sweden)

Full Text Available Generally failures of different aircraft components and parts are revealed and examined by the use of non-destructive examination methods. In further detailed explanation and interpretation of failures optical and scanning electron microscopy are used. This paper deals with a problem of a crack on aircraft wheel rim made from aluminium alloy 2014-T6.The crack was observed during regular control by the maintenance unit for non-destructive examination of the Slovenian air carrier Adria Airways. The crack on the rim of an aircraft wheel investigated was a typical fatigue crack. At same time a numerous pits were found which served as stress concentrations on the rim surface.

G. Kosec

2010-10-01

177

Pacific Rim markets for export coal and Australia's market share  

Energy Technology Data Exchange (ETDEWEB)

Pacific Rim markets for export coal already represent a larger market than the total tonnage imported into the European Community countries and they will continue to expand. The largest importers will continue to be in the sector comprising Japan, Korea, Hong Kong and Taiwan. It is likely that the total Pacific Rim markets will reach 206 m.t.p.a. by 1990 and 290 m.t.p.a. by 2000, with the major growth in steam coal demand. Australia has an efficient coal industry, represents a stable long term source of supply and is favourably situated geographically to continue to be the largest single supply source.

Edwards, G.E.

1982-09-01

178

Search for triggered star formation in the type A bright rimmed cloud 34  

Science.gov (United States)

Bright rimmed clouds (BRCs) near OB stars are excellent laboratories for the study of triggered star formation (TSF) due to the radiation driven implosion (RDI) mechanism. Type A BRCs are clouds at their earliest evolutionary stages and, according to the current theoretical modeling, are not expected to exhibit RDI TSF yet. Employing the Chandra's ability to effectively discern young stellar populations from unrelated old field objects we propose to observe the nearby Type A bright rimmed cloud BRC 34 and test predictions of RDI modelling. BRC 34 will also complement our large GO project on BRCs with the aim to study the RDI star formation efficiency in the Galaxy.

Garmire, Gordon

2008-09-01

179

Organization of lower rim O-alkylated p-phosphonic acid calix[4]arenes  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Lower rim O-methyl, -n-butyl, and n-octadecyl calix[4]arenes bearing p-phosphonic acid groups on the upper rim have been prepared in high yield, compounds 12-14. Where possible the compounds have been characterized in the solid state using X-ray diffraction, or as the precursor phosphate esters or a cesium salt. The cone conformation ethyl phosphate ester for the octadecyl compound crystallizes in a bi-layer 39.1 Å thick which approaches the 40 Å of biological membranes. The 1,3-alternate c...

2009-01-01

180

Nonimaging secondary concentrators for large rim angle parabolic troughs with tubular absorbers  

Science.gov (United States)

For parabolic trough solar collectors with tubular absorbers, we design new tailored secondary concentrators. The design is applicable for any rim angle of a parabolic reflector. With the secondary, the concentration can be increased by a factor of more than 2 with a compact secondary reflector consisting of a single piece, even for the important case of a rim angle of 90 deg. The parabolic reflector can be used without changes; the reduced absorber is still tubular but smaller than the original absorber and slightly displaced toward the primary. concentrators, solar trough collectors, tailored reflectors.

Ries, Harald; Spirkl, Wolfgang

1996-05-01

 
 
 
 
181

Search Efficient Representation of Healthcare Data based on the HL7 RIM  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Reference Information Model (RIM) of Health Level Seven (HL7) standard is a conceptual information model for health care. Data of HL7 RIM Observation class are sparse, high dimensional, and require frequent schema change. En...

Razan Paul; Abu Sayed Md. Latiful Hoque

2010-01-01

182

A case of cervical juxtafacet cyst with extensive rim enhancement on Gd-DTPA MRI.  

Science.gov (United States)

The authors reported a case of cervical juxtafacet cyst with extensive rim enhancement on gadolinium-diethylenetriamine pentaacid magnetic resonance imaging. Operative finding revealed the epidural space around the mass filled with abundant venous plexus. Histological examination demonstrated that cyst wall was composed of the well-vascularized fibrous connective tissue with some inflammatory changes. We speculate that extensive rim enhancement of juxtafacet cyst may be attributed not only to the chronic inflammatory changes of cyst wall, but to engorged venous plexus within the widened epidural space. PMID:24332973

Sasamori, Toru; Hida, Kazutoshi; Anzai, Kimio; Yano, Shunsuke; Kato, Yasutaka; Tanaka, Shinya; Saito, Hisatoshi; Houkin, Kiyohiro

2014-01-01

183

IISD RS @ CSD-20 Arab RIM, 29-30 May 2013, Dubai, UAE  

...IISD RS @ CSD-20 Arab RIM, 29-30 May 2013, Dubai, UAE Session of the Commission for Sustainable Development (CSD-20), 29-30 May 2013, ... Dubai, United Arab Emirates (UAE) Sustainable Development (CSD), Arab RIM for the 20th Session of the Commission for ...Sustainable Development (CSD-20), 29-30 May 2013, Dubai, United Arab Emirates (UAE) Summary Report Reporting Services (IISD RS) has produced a summary ...for the Twentieth Session of the Commission for Sustainable Development (CSD-20) 29-30 May 2013 | Dubai, United Arab Emirates (UAE) The Arab Regional Implementation ...

184

Olivine-rich rims surrounding chondrules in the Mokoia CV3 carbonaceous chondrite: Further evidence for parent-body processes  

Science.gov (United States)

Fine-grained rims surrounding chondrules and inclusions in the Mokoia CV3 carbonaceous chondrite can be divided into phyllosilicate-rich and olivine-rich types. We present a petrographic and electron microscopic study of the olivine-rich rims and their host objects (referred to as chondrules/olivine-rich rims). The olivine-rich rims consist mainly of Fe-rich olivine and very minor phyllosilicate (saponite). Their host chondrules contain minor saponite and phlogopite, which resulted from aqueous alteration of anhydrous silicates. Mineralogical and compositional characteristics of the chondrules/olivine-rich rims suggest that they experienced mild thermal metamorphic effects. The rims commonly contain veins of coarse-grained Fe-rich olivine, magnetite, and Fe-(Ni) sulfides. The chondrules show abundant evidence of alteration along their peripheries, and the alteration textures suggest a mechanism for rim formation by replacement of the chondrules. Initially, enstatite and opaque nodules preferentially reacted to form coarse, platy, Fe-rich olivine crystals, which were subsequently divided into finer grains. Forsterite was also replaced by Fe-rich olivine. As the alteration advanced, these Fe-rich olivines were disaggregated, mixed with simultaneously produced saponite, and formed rims. In contrast, the surrounding matrix shows no evidence of such alteration and metamorphism. These observations indicate that the chondrules/olivine-rich rims did not experience these secondary processes in their present setting. The results suggest that the chondrules/olivine-rich rims experienced extensive replacement reactions in an environment in which aqueous fluids existed but only in minor amounts. They have probably also undergone simultaneous and/or subsequent mild thermal metamorphism. We suggest that the chondrules/olivine-rich rims are actually clasts transported from a relatively dry region in the parent body that was different from the region where Mokoia was finally lithified.

Tomeoka, Kazushige; Ohnishi, Ichiro

2014-07-01

185

Physical and functional interaction between yeast Pif1 helicase and Rim1 single-stranded DNA binding protein.  

Science.gov (United States)

Pif1 helicase plays various roles in the maintenance of nuclear and mitochondrial genome integrity in most eukaryotes. Here, we used a proteomics approach called isotopic differentiation of interactions as random or targeted to identify specific protein complexes of Saccharomyces cerevisiae Pif1. We identified a stable association between Pif1 and a mitochondrial SSB, Rim1. In vitro co-precipitation experiments using recombinant proteins indicated a direct interaction between Pif1 and Rim1. Fluorescently labeled Rim1 was titrated with Pif1 resulting in an increase in anisotropy and a K(d) value of 0.69 µM. Deletion mutagenesis revealed that the OB-fold domain and the C-terminal tail of Rim1 are both involved in interaction with Pif1. However, a Rim1 C-terminal truncation (Rim1?C18) exhibited a nearly 4-fold higher K(d) value. Rim1 stimulated Pif1 DNA helicase activity by 4- to 5-fold, whereas Rim1?C18 stimulated Pif1 by 2-fold. Hence, two regions of Rim1, the OB-fold domain and the C-terminal domain, interact with Pif1. One of these interactions occurs through the N-terminal domain of Pif1 because a deletion mutant of Pif1 (Pif1?N) retained interaction with Rim1 but did not exhibit stimulation of helicase activity. In light of our in vivo and in vitro data, and previous work, it is likely that the Rim1-Pif1 interaction plays a role in coordination of their functions in mtDNA metabolism. PMID:23175612

Ramanagoudr-Bhojappa, Ramanagouda; Blair, Lauren P; Tackett, Alan J; Raney, Kevin D

2013-01-01

186

Detection of solar wind-produced water in irradiated rims on silicate minerals.  

Science.gov (United States)

The solar wind (SW), composed of predominantly ?1-keV H(+) ions, produces amorphous rims up to ?150 nm thick on the surfaces of minerals exposed in space. Silicates with amorphous rims are observed on interplanetary dust particles and on lunar and asteroid soil regolith grains. Implanted H(+) may react with oxygen in the minerals to form trace amounts of hydroxyl (-OH) and/or water (H2O). Previous studies have detected hydroxyl in lunar soils, but its chemical state, physical location in the soils, and source(s) are debated. If -OH or H2O is generated in rims on silicate grains, there are important implications for the origins of water in the solar system and other astrophysical environments. By exploiting the high spatial resolution of transmission electron microscopy and valence electron energy-loss spectroscopy, we detect water sealed in vesicles within amorphous rims produced by SW irradiation of silicate mineral grains on the exterior surfaces of interplanetary dust particles. Our findings establish that water is a byproduct of SW space weathering. We conclude, on the basis of the pervasiveness of the SW and silicate materials, that the production of radiolytic SW water on airless bodies is a ubiquitous process throughout the solar system. PMID:24449869

Bradley, John P; Ishii, Hope A; Gillis-Davis, Jeffrey J; Ciston, James; Nielsen, Michael H; Bechtel, Hans A; Martin, Michael C

2014-02-01

187

Constraints on the height of the inner disk rim in pre-main-sequence stars  

CERN Document Server

The structure of inner region of protoplanetary disks around young pre-main-sequence stars is still poorly understood. This part of the disk is shaped by various forces influencing dust and gas dynamics and by dust sublimation, which creates abrupt drops in the dust density. This region also emits a strong near-infrared excess that cannot be explained by classical accretion disk models, which suggests the existence of some unusual dust distribution or disk shape. The most prevalent explanation to date is the puffed-up inner disk rim model, where the disk exhibits an optically thin cavity around the star up to the distance of dust sublimation. The critical parameter in this model is the inner disk rim height $z_{\\rm max}$ relative to the rim's distance from the star $R_{\\rm in}$. Observations often require $z_{\\rm max}/R_{\\rm in}\\gtrsim0.2$ to reproduce the near-infrared excess in the spectra. In this paper we put together a comprehensive list of processes that can shape the inner disk rim and combined them to...

Vinkovi?, Dejan

2014-01-01

188

77 FR 18997 - Rim Lakes Forest Restoration Project; Apache-Sitgreavese National Forest, Black Mesa Ranger...  

Science.gov (United States)

...Rim Lakes Project Area to make--over time--the forest...purpose of the project is to restore...old growth management allocation...Eastern Time, Monday through...INFORMATION: This project is being authorized...and Resource Management Plan...

2012-03-29

189

Single stage reconstruction of alar rim defect using auricular composite graft: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available A case report of reconstruction of a post infective alar rim defect, in a girl of 13 years of age, occurring as a result of septic piercing of the nose, using a composite graft taken from the ear in a single stage is described.

Soni A

2005-01-01

190

Experimental liver cancers: Mn-DPDP-enhanced rims in MR-microangiographic-histologic correlation study.  

Science.gov (United States)

During both animal and clinical studies with manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP), enhanced rims around liver tumors on magnetic resonance (MR) images have been observed. To elucidate the origins of these rims and to assess their potential value in the differential diagnosis of liver masses, the authors studied 15 rats with induced hepatocellular carcinoma (HCC), 10 rats with implanted Novikoff hepatomas, and 11 rabbits with implanted VX2 carcinomas. A total of 69 primary and secondary liver cancers from these three animal models were studied. Mn-DPDP- and gadolinium tetraazacyclododecantetra acetic acid (DOTA)-enhanced MR images were compared. On the Mn-DPDP-enhanced images, 34 peritumoral rims of various patterns were displayed, all of which were exclusively related to the presence of highly malignant primary and secondary liver tumors. Peritumoral zones of malignant infiltration, surrounding parenchymal compression, and bile duct proliferation were seen to be the origin of these rims after comparison of MR images with the corresponding microangiograms and histologic specimens. PMID:8390071

Ni, Y; Marchal, G; Yu, J; Rummeny, E; Zhang, X; Lodemann, K P; Baert, A L

1993-07-01

191

A rare complication during percutaneous transcatheter closure of atrial septal defect: Atrial rim erosion  

Directory of Open Access Journals (Sweden)

Full Text Available In this report we persent a rare complication of Amplatzer septal occluder; associated with ‘atrial rim’ erosion during atrial septal defect closure. In our case report, we also present a brief review of literature of complications associated with transcatheter closure of atrial septal defects

Mehmet Erdem Memeto?lu

2011-06-01

192

Summary of the CSD-20 Arab RIM, 29-30 May 2013, Dubai, UAE  

...Session of the Commission for Sustainable Development (CSD-20), 29-30 May 2013, Dubai, United Arab Emirates (UAE) Sustainable Development (CSD), Summary ...for the 20th Session of the Commission for Sustainable Development (CSD-20), 29-30 May 2013, Dubai, United Arab Emirates (UAE) Summary of the CSD-20 ...Arab RIM, 29-30 May 2013, Dubai, UAE ...

193

Search Efficient Representation of Healthcare Data based on the HL7 RIM  

Directory of Open Access Journals (Sweden)

Full Text Available The Reference Information Model (RIM of Health Level Seven (HL7 standard is a conceptual information model for health care. Data of HL7 RIM Observation class are sparse, high dimensional, and require frequent schema change. Entity Attribute Value (EAV is the widely used solution to handle these above challenges of medical data, but EAV is not search efficient for knowledge extraction. In this paper, we have proposed a search efficient data model:  Optimized Entity Attribute Value (OEAV for physical representation of medical data as alternative of widely used EAV model. We have implemented EAV or OEAV individually to model RIM Observation class and used relational model for the remaining RIM classes. We have shown that OEAV is dramatically search efficient   and occupy less storage space compared to EAV.

Abu Sayed Md. Latiful Hoque

2010-12-01

194

Rim15p-mediated regulation of sucrose utilization during molasses fermentation using Saccharomyces cerevisiae strain PE-2.  

Science.gov (United States)

Inherited loss-of-function mutations in the Rim15p-mediated stress-response pathway contribute to the high fermentation rate of sake yeast strains. In the present study, we found that disruption of the RIM15 gene in ethanol-producing Saccharomyces cerevisiae strain PE-2 accelerated molasses fermentation through enhanced sucrose utilization following glucose starvation. PMID:23757382

Inai, Tomomi; Watanabe, Daisuke; Zhou, Yan; Fukada, Rie; Akao, Takeshi; Shima, Jun; Takagi, Hiroshi; Shimoi, Hitoshi

2013-11-01

195

Summary of the Asia and Pacific Regional RIM on Rio+20 Outcomes, 22-24 April 2013, Bangkok, Thailand  

...Outcomes, 22-24 April 2013, UN Conference Centre (UNCC), Bangkok, Thailand Report of the Asia and Pacific RIM on Rio+20 Outcomes, UN ...Conference Centre (UNCC), 22-24 April 2013, UNCC, Bangkok, Thailand Summary of the Asia and Pacific Regional RIM on Rio+...

196

The kinetics of dolomite reaction rim growth under isostatic and non-isostatic pressure conditions  

Science.gov (United States)

During burial and exhumation, rocks are simultaneously exposed to metamorphic reactions and tectonic stresses. Therefore, the reaction rate of newly formed minerals may depend on chemical and mechanical driving forces. Here, we investigate the reaction kinetics of dolomite (CaMg[CO3]2) rim growth by solid-state reactions experiments on oriented calcite (CaCO3) and magnesite (MgCO3) single crystals under isostatic and non-isostatic pressure conditions. Cylindrical samples of 3-5 mm length and 7 mm diameter were drilled and polished perpendicular to the rhombohedral cleavage planes of natural clear crystals. The tests were performed using a Paterson-type deformation apparatus at P = 400 MPa confining pressure, temperatures, T, between 750 and 850°C, and reaction durations, t, of 2 - 146 h to calculate the kinetic parameters of dolomite rim growth under isostatic stress conditions. For non-isostatic reaction experiments we applied in addition differential stresses, ?, up to 40 MPa perpendicular to the contact interface at T = 750°C for 4 - 171 h duration, initiating minor inelastic deformation of calcite. The thickness of the resulting dolomite reaction rims increases linearly with the square root of time, indicating a diffusion-controlled reaction. The rims consist of two different textural domains. Granular dolomite grains (? 2 -5 ?m grain size) form next to calcite and elongated palisade-shaped grains (1-6 ?m diameter) grow perpendicular to the magnesite interface. Texture measurements with the electron backscatter diffraction technique indicate that the orientations of dolomite grains are mainly influenced by the orientation of the calcite educt crystal, in particular in the granular rim. To some extent, the texture of dolomite palisades is also influenced by the orientation of magnesite. The thickness of the two individual layers increases with temperature. At 400 MPa isostatic pressure, T = 750°C and t = 29 hours, a 5 ?m thick granular dolomite layer and a 7 ?m thick palisade-shaped layer evolve. At similar conditions and a differential stress of 30 MPa, the rim thickness remains similar; consequently the effect of non-isostatic stress on dolomite rim growth is negligible. Platinum markers show that the initial calcite-magnesite interface is located between granular and palisade-forming dolomite, indicating that rim growth occurs by counter diffusion of MgO and CaO. Diffusion of MgO across the dolomite reaction rim into calcite forms additionally magnesio-calcite grains with diameters of ? 13 - 46 ?m, depending on the experimental conditions and increasing with increasing distance to the dolomite boundary. At T = 750°C, t = 29 hours, the thickness of the magnesio-calcite layer is 32 ?m (isostatic) - 35 ?m (? = 30 MPa). The experiments indicate that solid-state reaction rim growth of dolomite between calcite and magnesite is primarily controlled by diffusion of MgO and CaO, forming layers with different microstructures during growth into the educt phases. The kinetics of the reaction in the carbonate system are not significantly changed by differential stresses up to 40 MPa. We suggest that volume diffusion is the dominant transport mechanism, which is presumably less affected by non-isostatic stresses than grain boundary diffusion.

Helpa, V.; Rybacki, E.; Morales, L. G.; Abart, R.; Dresen, G. H.

2013-12-01

197

Calculation of ejecta thickness and structural uplift for Lunar and Martian complex crater rims.  

Science.gov (United States)

Crater rims of simple and complex craters have an elevation that is formed during the excavation stage of crater formation. For simple crater rims it is believed that the elevation is due to the sum of two equal parts, the thickness of the most proximal impact ejecta blanket (overturned flap) plus the thickness that results from plastic deformation including injection [1, 2, 3]. We intend to measure and quantify the kinematics of mass movements, especially concerning the question why complex impact craters have elevated crater rims like simple craters and precisely constrain the ejecta thickness and structural uplift of Lunar and Martian crater rims to understand what the main contributor to the elevated rim is [4]. We investigated a pristine 16 km-diameter unnamed Martian complex crater (21.52°N, 184.35°) and the lunar complex craters Bessel (21.8°N, 17.9°E) 16 km in diameter and Euler (23.3°N, 29.2°W) 28 km in diameter [5, 6]. In the crater walls of these craters we found columnar lavas on Mars and basaltic layering on the Moon. We used the uppermost layers of these exposed outcrops along the crater wall to determine the dip of the target rocks (Mars) and to distinguish between the bedrock and the overlying ejecta. We precisely measured the structural uplift and ejecta thickness of these complex craters. The unnamed crater on Mars has a mean rim height of 375.75 m, with a structural uplift of 233.88 m (57.44%), exposed as columnar lavas and the superposing ejecta has a height of 141.87 m (43.56%). For the Lunar complex crater Euler the mean total rim height is 790 ± 100 m, with a minimal structural uplift of 475 ± 100 m (60 ± 10 %), exposed as basaltic layers [e.g., 7, 8] and a maximum ejecta thickness of 315 ± 100 m (40 ± 10%). The Lunar complex crater Bessel has a total rim height of 430 ± 15 m , with a minimal structural uplift of 290 ± 15 m (67 ± 3 %), exposed as basaltic layers and a maximum ejecta thickness of 140 ± 115 m (33 ± 3%). For the Martian crater, the calculated structural uplift has a value of 215.83 m [9]. For Euler and Bessel crater calculated values for the structural uplift are 310.76 m and 262.8 m, respectively [10]. The structural uplift of the crater rim only by dike injection and plastic deformation in the underlying target material seems unlikely at distances ~1 km beyond the transient crater cavity. Other mechanisms, like reverse faulting, beginning in the excavation stage of crater formation, could be responsible for additional structural uplift of the crater rim. Nevertheless, our results show that structural uplift is a more dominant effect than ejecta emplacement for complex impact craters. References: [1] Melosh H.J. (1989) Oxford monographs on geology and geophysics, 11, Impact cratering: a geologic process. [2] Poelchau M.H. et al. (2009) JGR, 114, E01006. [3] Shoemaker E. M. (1963) The Solar System, 4, 301-336. [4] Settle M., and Head J.W. (1977) Icarus, v. 31, p. 123. [5] Sturm, S. et al. (2014) LPSC 45, #1801. [6] Krüger T. et al. (2014) LPSC 45, #1834. [7] Hiesinger H. et al. (2002) GRL, 29. [8] Enns A.C. (2013) LPSC XLIV, #2751. [9] Steward S. T. and Valiant G. J. (2006) Meteoritics & Planet. Sci., 41, 1509-1537. [10] Pike R. J. (1974) EPSL, 23, 265-274. [11]Turtle, E. et al. (2005) GSA-SP. 384, 1.

Krüger, Tim; Sturm, Sebastian; Kenkmann, Thomas

2014-05-01

198

Constraints on the height of the inner disk rim in pre-main-sequence stars  

Science.gov (United States)

The structure of inner region of protoplanetary disks around young pre-main-sequence stars is still poorly understood. This part of the disk is shaped by various forces that influence dust and gas dynamics, and by dust sublimation, which creates abrupt drops in the dust density. This region also emits strong near-infrared excess that cannot be explained by classical accretion disk models, which suggests the existence of some unusual dust distribution or disk shape. The most prevalent explanation to date is the puffed-up inner disk rim model, where the disk exhibits an optically thin cavity around the star up to the distance of dust sublimation. The critical parameter in this model is the inner disk rim height zmax relative to the rim distance from the star Rin. Observations often require zmax/Rin ? 0.2 to reproduce the near-infrared excess in the spectra. We compile a comprehensive list of processes that can shape the inner disk rim and combine them into a self-consistent model. Two of them, radiation pressure force and the gas velocity profile, have never been applied in this context before. The aim was to find the most plausible theoretical values of zmax/Rin. The results show that this value is ?0.13 for Herbig Ae stars, ?0.11 for T Tau stars, and ?0.10 for young brown dwarfs. This is lower than the observational requirements for Herbig Ae stars. We argue that the same problem exists in T Tau stars as well. We conclude that the puffed-up inner rim model cannot be the sole explanation for the near-infrared excess in young pre-main-sequence stars. Appendix is available in electronic form at http://www.aanda.org

Vinkovi?, D.

2014-06-01

199

Strontium isotope analysis using resonance ionization mass spectrometry for determination of bone origin  

International Nuclear Information System (INIS)

We have considered the applicability of strontium isotope analysis, using Laser Ablation-assisted Resonance Ionization Mass Spectrometry (LA-RIMS), to the determination of bone origin. We separated the uncertainty into two categories: ion counting statistics, and short-term or uncontrollable shifts of experimental conditions; only the former decreases with increasing signal intensity. Additionally, we confirmed that long-term shifts of isotope ratio in LA-RIMS can be cancelled by an internal correction method. We preliminarily estimated the precision of our technique to be 0.7% (1?) for 105 laser shots; the accuracy is also confirmed within the present uncertainty through the comparison with a reference value. (author)

2008-09-01

200

Development of an Upper Cambrian rimmed shelf along the Mississippi Valley Graben, Reelfoot Rift, and the southeastern Ozarks, southern Missouri  

Energy Technology Data Exchange (ETDEWEB)

The paleogeographic distribution of intrashelf basin shales and limestones in the Bonneterre (Dresbachian) and Davis (Franconian) Formations, and associated data, suggests that rimmed shelf conditions separated the central Missouri part of the shelf from the Mississippi Valley Graben (MVG) of the Reelfoot Rift to the southeast. Middle Dresbachian rocks of the intrashelf basin area, predominantly limestones, indicate a discontinuous carbonate shelf rim. The succeeding widespread shales of the Franconian intrashelf basin indicate that a continuous rim had developed. The margin of the shelf rim is preserved in part of the 4,700-ft-thick Upper Cambrian succession along the northwest margin of the Mississippi Valley Graben (MVG) of the Reelfoot Rift. Equivalent rocks within the MVG are dominantly dark shales (1,600+ ft thick). The Amoco Spence test well penetrated the rim succession on the northwest margin of the MVG. At least 11 large-scale transgressive-regressive (T-R) carbonate cycles (120--600 ft thick) have been defined in this well; 7 cycles are equivalent to the Bonneterre and Davis Formations. These latter cycles have shaly limestone, or limestone at the base, and grade upward to dolostone or coarsely crystalline dolostone, which are interpreted to be shallowing-upward, bank margin-peritidal carbonates. Northwest of the rim margin and on the southeast side of the St. Francois Mountains, rocks equivalent to the rim succession consist of a series of ramp to platform cycles made up of dolostones and local limestones. Many carbonate shelves on passive margins are rimmed. The development of this Upper Cambrian rimmed shelf along the northwest margin of the MVG suggests that failed rifts can also localized such rims.

Palmer, J.R. (Missouri Geological Survey Program, Rolla, MO (United States). Dept. of Natural Resources)

1993-03-01

 
 
 
 
201

68Ga-DOTA-NOC PET/CT in comparison with CT for the detection of bone metastasis in patients with neuroendocrine tumours  

International Nuclear Information System (INIS)

To retrospectively evaluate the sensitivity, specificity and accuracy of 68Ga-DOTA-NOC PET/CT and CT alone for the evaluation of bone metastasis in patients with neuroendocrine tumour (NET). From among patients with NET who underwent 68Ga-DOTA-NOC PET/CT between April 2006 and November 2008 in our centre, 223 were included in the study. Criteria for inclusion were pathological confirmation of NET and a follow-up period of at least 10 months. PET and CT images were retrospectively reviewed by two nuclear medicine specialists and two radiologists, respectively, without knowledge of the patient history or the findings of other imaging modalities. PET data were compared with the CT findings. Interobserver agreement was evaluated in terms of the kappa score. Clinical and imaging follow-up were used as the standard of reference to evaluate the PET findings. PET was performed for staging (49/223), unknown primary tumour detection (24/223), restaging (32/223), restaging before radioimmunotherapy (1/223), evaluation during therapy (12/223), equivocal findings on conventional imaging (4/223 at the bone level; 61/223 at sites other than bone), and follow-up (40/223). A very high interobserver agreement was observed. CT detected at least one bone lesion in only 35 of 44 patients with a positive PET scan. In particular, PET showed more lesions in 20/35 patients, a lower number of lesions in 8/35, and the same number in 7/35. The characteristics of the lesions (sclerotic, lytic, mixed) on the basis of the CT report did not influence PET reading. PET revealed the presence of at least one bone metastasis in nine patients with a negative CT scan. Considering patients with a negative PET scan (179), CT showed equivocal findings at the bone level in three (single small sclerotic abnormality in two at the spine level, and bilateral small sclerotic abnormalities in the humeri, femurs and scapula). Clinical follow-up confirmed the PET findings in all patients; thus there were no false-positive or false-negative findings. Considering all patients, PET detected more lesions than CT (246 vs. 194). As compared to CT, on a patient basis PET showed a higher sensitivity (100% vs. 80%), specificity (100% vs. 98%), positive predictive value (100% vs. 92%), and negative predictive value (100% vs. 95%). In conclusion, 68Ga DOTA-NOC PET was more accurate than CT for the identification of bone lesions and led to a change in clinical management in nine patients with a negative CT scan. (orig.)

2010-04-01

202

Three-dimensional microstructural analysis of human lumber vertebrae using microcomputed tomography in bone metastasis from prostate cancer  

Energy Technology Data Exchange (ETDEWEB)

Prostate cancer frequently metastasizes to bone, inducing osteosclerotic lesions. However, the morphological details of bone metastasis of prostate cancer have not been clarified. The trabecular bone structure of bone metastasis from prostate cancer was investigated in three dimensions using microcomputed tomography (micro-CT). A total of 17 cubes of the lumber spine of a 77-year-old man with prostate cancer were excised post mortem: four of them from non-metastatic and the rest from metastatic sites. The samples were measured using micro-CT with a resolution of 23.2 {mu}m and the standard structural indices and degree of anisotropy were computed. After micro-CT measurement, the samples were tested in a destructive manner for the assessment of mechanical properties. Samples from the metastatic sites showed significantly higher values than those from non-metastatic sites for bone volume (BV), bone surface (BS), bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N) (p<0.005). Bone surface density (BS/BV) and trabecular separation (Tb.Sp) were significantly higher in the samples from non-metastatic sites (p<0.001). Samples from metastatic sites showed a more isotropic arrangement of trabecular bone than those from non-metastatic sites. Three-dimensionally reconstructed images depicted several different patterns of sclerotic bone metastasis, and osteolytic appearance was observed in all of them. Structural parameters such as BV/TV were well correlated with the mechanical properties (r=0.899). The present study clarified the trabecular microstructure of bone metastasis from prostate cancer and suggests that both osteolysis and osteogenesis progress while interacting with each other in all phases of bone metastasis. (author)

Tamada, Tsutomu [Kawasaki Medical School, Kurashiki, Okayama (Japan)

2000-11-01

203

Functional Coupling of Rab3-interacting Molecule 1 (RIM1) and L-type Ca2+ Channels in Insulin Release*  

Science.gov (United States)

Insulin release by pancreatic ?-cells is regulated by diverse intracellular signals, including changes in Ca2+ concentration resulting from Ca2+ entry through voltage-gated (CaV) channels. It has been reported that the Rab3 effector RIM1 acts as a functional link between neuronal CaV channels and the machinery for exocytosis. Here, we investigated whether RIM1 regulates recombinant and native L-type CaV channels (that play a key role in hormone secretion) and whether this regulation affects insulin release. Whole-cell patch clamp currents were recorded from HEK-293 and insulinoma RIN-m5F cells. RIM1 and CaV channel expression was identified by RT-PCR and Western blot. RIM1-CaV channel interaction was determined by co-immunoprecipitation. Knockdown of RIM1 and CaV channel subunit expression were performed using small interference RNAs. Insulin release was assessed by ELISA. Co-expression of CaV1.2 and CaV1.3 L-type channels with RIM1 in HEK-293 cells revealed that RIM1 may not determine the availability of L-type CaV channels but decreases the rate of inactivation of the whole cell currents. Co-immunoprecipitation experiments showed association of the CaV? auxiliary subunit with RIM1. The lack of CaV? expression suppressed channel regulation by RIM1. Similar to the heterologous system, an increase of current inactivation was observed upon knockdown of endogenous RIM1. Co-immunoprecipitation showed association of CaV? and RIM1 in insulin-secreting RIN-m5F cells. Knockdown of RIM1 notably impaired high K+-stimulated insulin secretion in the RIN-m5F cells. These data unveil a novel functional coupling between RIM1 and the L-type CaV channels via the CaV? auxiliary subunit that contribute to determine insulin secretion.

Gandini, Maria A.; Sandoval, Alejandro; Gonzalez-Ramirez, Ricardo; Mori, Yasuo; de Waard, Michel; Felix, Ricardo

2011-01-01

204

The RIM101 Pathway Contributes to Yeast Cell Wall Assembly and Its Function Becomes Essential in the Absence of Mitogen-Activated Protein Kinase Slt2p  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The Saccharomyces cerevisiae ynl294c? (rim21?) mutant was identified in our lab owing to its moderate resistance to calcofluor, although it also displayed all of the phenotypic traits associated with its function as the putative sensor (Rim21p) of the RIM101 pathway. rim21? also showed moderate hypersensitivity to sodium dodecyl sulfate, caffeine, and zymolyase, and the cell wall compensatory response in this mutant was very poor, as indicated by the almost complete absence of Slt2 phospho...

Castrejon, F.; Gomez, A.; Sanz, M.; Duran, A.; Roncero, C.

2006-01-01

205

To divide or not to divide: a key role of Rim15 in calorie-restricted yeast cultures.  

Science.gov (United States)

The PAS kinase Rim15 is proposed to integrate signals from different nutrient-sensing pathways and to control transcriptional reprogramming of Saccharomyces cerevisiae upon nutrient depletion. Despite this proposed role, previous transcriptome analyses of rim15 mutants solely focused on growing cultures. In the present work, retentostat cultivation enabled analysis of the role of Rim15 under severely calorie-restricted, virtually non-growing conditions. Under these conditions, deletion of RIM15 affected transcription of over 10-fold more genes than in growing cultures. Transcriptional responses, metabolic rates and cellular morphology indicated a key role of Rim15 in controlled cell-cycle arrest upon nutrient depletion. Moreover, deletion of rim15 reduced heat-shock tolerance in non-growing, but not in growing cultures. The failure of rim15 cells to adapt to calorie restriction by entering a robust post-mitotic state resembles cancer cell physiology and shows that retentostat cultivation of yeast strains can provide relevant models for healthy post-mitotic and transformed human cells. PMID:24487068

Bisschops, Markus M M; Zwartjens, Priscilla; Keuter, Sebastiaan G F; Pronk, Jack T; Daran-Lapujade, Pascale

2014-05-01

206

Bone loss: Epidemiology of bone loss  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Bone loss occurs when the cellular events of bone formation are quantitatively larger than bone formation. This manuscript discusses the measurement of bone loss, occurrence in the population, risk factors and consequences of bone loss. Recent developments in bone mass measurement and biomarkers have improved our ability to assess bone loss. This process is a normal concomitant of ageing. There are a number of other risk factors, including sex hormone deficiency, physical inactivity, calcium/...

Hunter, David J.; Sambrook, Philip N.

2000-01-01

207

Asia/Pacific Rim renewable energy market assessments by the State of Hawaii  

International Nuclear Information System (INIS)

The State of Hawaii has begun to encourage its economic growth and diversification by increasing the export of U.S. energy, environment, ocean, and information technologies. Hawaii's Strategic Technology Market Assessment and Development (STMAD) program promotes the transfer of U.S. technology into Asia and the Pacific Rim, locations having phenomenal growth potential and vast technological infrastructure demands. The STMAD program is managed by the State's Department of Business, Economic Development and Tourism (DBEDT). Under the auspices of STMAD, the Hawaii Natural Energy Institute (HNEI) of the University of Hawaii is assessing biomass energy resources of Asian and Pacific Rim countries to identify and investigate sustainable energy markets. This paper reviews the STMAD program and reports findings of renewable energy assessment performed by HNEI and DBEDT. (author)

1999-09-02

208

Direct measurement of the separation factor with 235U-enriched UF5 particles in RIMLIS  

International Nuclear Information System (INIS)

The collection system for 235U-enriched UF5 particles was designed for a newly-built reactor with much higher pumping capacity in molecular laser isotope separation at RIKEN (RIMLIS). A multi-jet low pressure impactor was used as a collector for ultrafine UF5 particles. ?-Spectra of the collected product particles were measured with a Si detector to determine the separation factor directly from the isotopic ratio of the product particles. The separation factor was also obtained from the measurements of the isotopic ratio of the residual UF6 gas and fractional conversion of UF6 gas. The separation factor obtained from the isotopic ratio of collected product particles agreed well with the separation factor obtained from residual gas phase isotopic ratio. We confirmed that we collected the UF5 particles which were enriched 235U by RIMLIS. (author)

1990-11-01

209

Ultrasonic inspection method and system for detection of steeple cracking in turbine disk rims  

International Nuclear Information System (INIS)

Steam turbine disks which operate under high cyclic stress in a moist environment can develop cracks in the disk-rim steeples. Detection of these cracks using nondestructive testing methods is necessary to assure safe operation and avoid unnecessary disk replacement. Both magnetic particle (MT) and ultrasonic testing (UT) can be used to inspect the steeples; however, UT can be used without removing the blades. A system for inspecting bladed steeples has been developed that can be applied on a range of disks including those in Westinghouse, General Electric, and Allis Chalmers turbines. The system performs an inspection as the turbine is rotated at slow speeds over turning rolls. This procedure greatly reduces inspection time because the inspection can be done without deblading the disk or resetting the inspection equipment for different rim segments

1990-11-01

210

The hot rim sign on hepatobiliary scintigraphy (HIDA) with CT correlation.  

Science.gov (United States)

An older male with multiple medical comorbidities presented to the emergency room after 3 days of worsening right upper quadrant pain. The patient had an elevated white blood cell count and mildly elevated liver functions. Initial ultrasound was equivocal and further imaging with CT scan was obtained. The CT scan was read as suggestive of cholecystitis, however a hepatobiliary scintigraphy (HIDA) scan was ordered for confirmation, as the patient was a poor operative candidate. The HIDA demonstrated no bile duct or small bowel activity on initial images or delays, however a classic 'hot rim' sign was present, confirming acute cholecystitis. The patient ultimately underwent percutaneous cholecystostomy with drainage for treatment where acute cholecystitis was confirmed. Upon retrospective review, the CT demonstrated hyperaemia surrounding the gallbladder fossa, which is the CT scan equivalent of a scintigraphic 'hot rim' sign. This is an uncommon example of a radiologic sign correlation between multiple imaging modalities. PMID:22665866

Amber, Ian Blake; Leighton, Joshua; Li, Su-Yu; Greene, Gary Stuart

2012-01-01

211

Theoretical and experimental research of hammer forging process of RIM from AZ31 magnesium alloy  

Directory of Open Access Journals (Sweden)

Full Text Available The results of theoretical analysis and experimental tests of hammer forging process of rim part from AZ31 magnesium alloy are presented in this paper. On the basis of numerical simulation results, the analysis of limiting phenomena was made. These phenomena include: possibility of overlapping presence, not filling of die impression, overheating of material and cracks. The results of theoretical analysis provided the support for planning of experimental tests in industrial conditions. Forging tests were conducted in one of Polish forming plants, applying steam-air hammer of blow energy 63 kJ. On the basis of experimental verification, it was stated that it is possible to obtain rim forging from AZ31 alloy of assumed quality in the hammer forging process.

A. Gontarz

2014-10-01

212

Distribution of skeletal muscle involvement in distal myopathy with rimmed vacuoles  

International Nuclear Information System (INIS)

Distribution of skeletal muscle involvement was studied clinically and by computed tomography (CT) in 6 cases (including 5 sporadic cases) with rimmed vacuolar distal myopathy. Although a predilection for the extensors in the lower leg was noted as stressed so far, there were certain cases without this selectivity. The thigh disclosed a selectivity that the flexors and adductors were severely affected while the m. quadriceps femoris was well preserved. The selectivity in the thigh was still found in the cases without selectivity in the lower leg. The neck flexors were also liable to be involved. In addition, CT revealed no compensatory hypertrophy of the specific muscles which was clearly shown in the thigh of distal muscular dystrophy (Miyoshi). The pattern of skeletal muscle involvement was thought to be a characteristic feature of distal myopathy with rimmed vacuoles. It was visualized very clearly and easily by CT of skeletal muscles although it could be noted to a certain degree by physical examination. (author)

1986-01-01

213

A sign-reversing involution for rooted special rim-hook tableaux  

CERN Multimedia

Egecioglu and Remmel gave an interpretation for the entries of the inverse Kostka matrix K^{-1} in terms of special rim-hook tableaux. They were able to use this interpretation to give a combinatorial proof that KK^{-1}=I but were unable to do the same for the equation K^{-1}K=I. We define a sign-reversing involution on rooted special rim-hook tableaux which can be used to prove that the last column of this second product is correct. In addition, following a suggestion of Chow we combine our involution with a result of Gasharov to give a combinatorial proof of a special case of the (3+1)-free Conjecture of Stanley and Stembridge.

Sagan, B E; Sagan, Bruce E.; Lee, Jaejin

2003-01-01

214

Asia/Pacific Rim renewable energy market assessments by the State of Hawaii  

Energy Technology Data Exchange (ETDEWEB)

The State of Hawaii has begun to encourage its economic growth and diversification by increasing the export of U.S. energy, environment, ocean, and information technologies. Hawaii's Strategic Technology Market Assessment and Development (STMAD) program promotes the transfer of U.S. technology into Asia and the Pacific Rim, locations having phenomenal growth potential and vast technological infrastructure demands. The STMAD program is managed by the State's Department of Business, Economic Development and Tourism (DBEDT). Under the auspices of STMAD, the Hawaii Natural Energy Institute (HNEI) of the University of Hawaii is assessing biomass energy resources of Asian and Pacific Rim countries to identify and investigate sustainable energy markets. This paper reviews the STMAD program and reports findings of renewable energy assessment performed by HNEI and DBEDT. (author)

Ishimura, D.M.; Kinoshita, C.M.; Turn, S.Q. [University of Hawaii at Manoa, Honolulu (US)] [and others

1999-07-01

215

Disorders of Bone Remodeling  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The skeleton provides mechanical support for stature and locomotion, protects vital organs, and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone modeling to carry out these crucial functions throughout life. Bone remodeling involves the removal of old or damaged bone by osteoclasts (bone resorption) and the subsequent replacement of new bone formed by osteoblasts (bone formation). Normal bone remodeling requires a tight coupling of bone resorption to bone f...

Feng, Xu; Mcdonald, Jay M.

2011-01-01

216

Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background The autophagic vacuolar myopathies (AVM) are a group of inherited myopathies defined by the presence of autophagic vacuoles in pathological muscle specimens. AVM can be categorized into three groups: acid maltase deficiency, myopathies characterized by autophagic vacuoles with unique sarcolemmal features, and rimmed vacuolar myopathies (RVM). While the pathogeneses of these conditions are still being elucidated, some drugs (e.g., chloroquine, its analog, h...

2012-01-01

217

Aeolian activity during the last 9200 calendar years BP along the southwestern coastal rim of Norway  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Aeolian sand deposits intercalated with organic layers have been reported from Holocene sediment sequences below the marine limit (ML) at twelve sites along the coastal rim of southwestern Norway for over a century. This study, based on field investigations, stratigraphical analysis, radiocarbon dates and archaeological information, has revealed several phases of aeolian activity. The premises and factors permitting sand drift, as well as the timing of this activity, have been compiled and sy...

Prøsch-danielsen, Lisbeth; Selsing, Lotte

2009-01-01

218

Mineral resources of the Massacre Rim Wilderness Study Area, Washoe County, Nevada  

International Nuclear Information System (INIS)

The Massacre Rim Wilderness Study Area encompasses 23,260 acres in Northwest Nevada. There is moderate mineral resource potential for gold, silve, and mercury in hydrothermal deposits in the eastern part of the study area. There is moderate mineral resource potential for uranium throughout the study area. There is no potential for oil and gas in the study area. The potential for geothermal resources is unknown

1988-01-01

219

Mineral resources of the Massacre Rim Wilderness Study Area, Washoe County, Nevada  

Energy Technology Data Exchange (ETDEWEB)

The Massacre Rim Wilderness Study Area encompasses 23,260 acres in Northwest Nevada. There is moderate mineral resource potential for gold, silve, and mercury in hydrothermal deposits in the eastern part of the study area. There is moderate mineral resource potential for uranium throughout the study area. There is no potential for oil and gas in the study area. The potential for geothermal resources is unknown.

Bergquist, J.R.; Plouff, D.; Turner, R.L.; Causey, J.D.

1988-01-01

220

Determinants and structural development of FDI in Pacific-Rim developing countries  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The movements of foreign direct investment (FDI) in the recent past are marked by a relatively very high growth in the Pacific Rim (PR) countries (Australia, Brunei, China, Hongkong, Japan, Indonesia, Malaysia, Papua New Guinea, New Zealand, Philippines, Singapore, Taiwan, Thailand). The developing countries of this area were able to raise considerably their share of the total world outflows in the first half of this decade (Table Al) . In the following analysis an attempt is made to work out...

1989-01-01

 
 
 
 
221

The productive efficiency of ports: Lessons from the Pacific Rim Seaport's  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This research is to evaluate whether and how global port reform efforts since the early 1990s strongly pursued in many Pacific Rim countries such as Australia, New Zealand, Singapore, China and many other ports in Latin America contribute to higher productivity. The research, as the basis of Mr. SangHyun Cheon's Ph.D. dissertation (the graduate student researcher conducting this research), theoretically aims to understand the ways port institutions, such as port ownership and corporate struct...

Cheon, Sanghyun

2007-01-01

222

A Compact Array imaging survey of southern bright-rimmed clouds  

CERN Document Server

We have carried out a radio-wavelength imaging survey of 45 bright-rimmed clouds (BRCs), using the Australia Telescope Compact Array to characterise the physical properties in their ionised boundary layers. We detected radio emission from a total of 25 clouds and using a combination of Digitised Sky Survey and mid-infrared MSX micron images classified the emission into that associated with the ionised cloud rims, that associated with embedded possible massive YSOs and that unlikely to be associated with the clouds at all. A total of 18 clouds display radio emission clearly associated with the cloud rim and we determine the ionising photon flux illuminating these clouds and the electron density and pressure of their ionised boundary layers. Using a global estimate for the interior molecular pressure of these clouds we show that the majority are likely to be in pressure equilibrium and hence are currently being shocked by photoionisation-induced shocks. We identify those clouds where the predicted ionising phot...

Thompson, M A; White, G J

2004-01-01

223

Conserved arginines on the rim of Hfq catalyze base pair formation and exchange  

Science.gov (United States)

The Sm-like protein Hfq is required for gene regulation by small RNAs (sRNAs) in bacteria and facilitates base pairing between sRNAs and their mRNA targets. The proximal and distal faces of the Hfq hexamer specifically bind sRNA and mRNA targets, but they do not explain how Hfq accelerates the formation and exchange of RNA base pairs. Here, we show that conserved arginines on the outer rim of the hexamer that are known to interact with sRNA bodies are required for Hfq’s chaperone activity. Mutations in the arginine patch lower the ability of Hfq to act in sRNA regulation of rpoS translation and eliminate annealing of natural sRNAs or unstructured oligonucleotides, without preventing binding to either the proximal or distal face. Stopped-flow FRET and fluorescence anisotropy show that complementary RNAs transiently form a ternary complex with Hfq, but the RNAs are not released as a double helix in the absence of rim arginines. RNAs bound to either face of Hfq quench the fluorescence of a tryptophan adjacent to the arginine patch, demonstrating that the rim can simultaneously engage two RNA strands. We propose that the arginine patch overcomes entropic and electrostatic barriers to helix nucleation and constitutes the active site for Hfq’s chaperone function.

Panja, Subrata; Schu, Daniel J.; Woodson, Sarah A.

2013-01-01

224

Young Stellar Population of the Bright-Rimmed Clouds BRC 5, BRC 7 and BRC 39  

CERN Document Server

Bright-rimmed clouds (BRCs), illuminated and shaped by nearby OB stars, are potential sites of recent/ongoing star formation. Here we present an optical and infrared photometric study of three BRCs: BRC 5, BRC 7 and BRC 39 to obtain a census of the young stellar population, thereby inferring the star formation scenario, in these regions. In each BRC, the Class I sources are found to be located mostly near the bright rim or inside the cloud, whereas the Class II sources are preferentially outside, with younger sources closer to the rim. This provides strong support to sequential star formation triggered by radiation driven implosion due to the UV radiation. Moreover, each BRC contains a small group of young stars being revealed at its head, as the next-generation stars. In particular, the young stars at the heads of BRC 5 and BRC 7 are found to be intermediate/high mass stars, which, under proper conditions, may themselves trigger further star birth, thereby propagating star formation out to long distances.

Panwar, Neelam; Pandey, A K; Samal, M R; Ogura, K; Ojha, D K; Jose, J; Bhatt, B C

2014-01-01

225

Conserved arginines on the rim of Hfq catalyze base pair formation and exchange.  

Science.gov (United States)

The Sm-like protein Hfq is required for gene regulation by small RNAs (sRNAs) in bacteria and facilitates base pairing between sRNAs and their mRNA targets. The proximal and distal faces of the Hfq hexamer specifically bind sRNA and mRNA targets, but they do not explain how Hfq accelerates the formation and exchange of RNA base pairs. Here, we show that conserved arginines on the outer rim of the hexamer that are known to interact with sRNA bodies are required for Hfq's chaperone activity. Mutations in the arginine patch lower the ability of Hfq to act in sRNA regulation of rpoS translation and eliminate annealing of natural sRNAs or unstructured oligonucleotides, without preventing binding to either the proximal or distal face. Stopped-flow FRET and fluorescence anisotropy show that complementary RNAs transiently form a ternary complex with Hfq, but the RNAs are not released as a double helix in the absence of rim arginines. RNAs bound to either face of Hfq quench the fluorescence of a tryptophan adjacent to the arginine patch, demonstrating that the rim can simultaneously engage two RNA strands. We propose that the arginine patch overcomes entropic and electrostatic barriers to helix nucleation and constitutes the active site for Hfq's chaperone function. PMID:23771143

Panja, Subrata; Schu, Daniel J; Woodson, Sarah A

2013-08-01

226

An attempt to simulate the porosity buildup in the rim at high burnup  

International Nuclear Information System (INIS)

The 'rim effect' was identified fifteen years ago with the examination of the first rods irradiated over 45 GWd/tU (pellet average burnup) in test reactors as well as in power plants. Detailed PIE have shown a progressive disappearance of the grain structure in the fuel periphery, in relation with a strong increase of the porosity. A scenario for the rim buildup at high burnup is proposed. Regarding the role of the porosity on the evolution of the physical properties, the first step has been an attempt to simulate the fission gas behaviour in the rim. In the proposed model, bubble growing is related to the volume fraction of the fuel restructured. An assumption is made on the creation of short cuts, increasing the average Xenon diffusion rate at very short distances. This model allows to evaluate the pore volume fraction in the fuel, the mean size of these pores and the fission gas volume repartition within the bubbles and the fuel matrix. The model presented herein was issued in the framework of a PhD, held on May 31st. 1996 in the Marseille II University by Dr. Bruna HERMITTE. (author)

1998-08-01

227

Automated geometry measurement of wheel rims based on optical 3D metrology  

Science.gov (United States)

One of the economically most important branches is the automotive industry with their component suppliers. The high degree of automation in manufacturing processes, requires automated control and quality assurance equally. In this scope, we present a complex 3D measuring device, consisting of multiple optical 3D sensors, which is designed to capture the geometry of wheel rims. The principal challenge for automated measurements is the variety of rims with respect to design, dimensions and the production flow. Together with connected conveyers, the system automatically sorts good rims without interrupting the manufacturing process. In this work we consider three major steps. At first we discuss the application of the used 3D sensors and the underlying measuring principles for the 3D geometry acquisition. Therefore, we examine the hardware architecture, which is needed to fulfill the requirements concerning to the variety of shapes and to the measuring conditions in industrial environments. In the second part we focus on the automated calibration procedure to integrate and combine the data from the set of sensors. Finally, we introduce the algorithms for the 3D geometry extraction and the mathematical methods which are used for the data preprocessing and interpretation.

Teutsch, Christian; Berndt, Dirk; Schmidt, Nico; Trostmann, Erik

2006-11-01

228

Bone lesions  

International Nuclear Information System (INIS)

The purpose of this study is to evaluate the ability of opposed-phase T2*-weighted gradient-field-echo (T2*FE) MR imaging to image bone lesions. The series included 27 bone tumors and 12 benign compression fractures. Images were acquired on a 0.5 T magnet with T2*FE imaging (300/22[repetition time msec/echo time msec], 20deg). Results were compared with those of T1-weighted spin-echo (T1 SE) images (500/20-40) and T2-weighted spin-echo(T2 SE) images (2000/80). Shorter (about one-third or two-third) scanning time was required to obtain T2*FE images than to obtain T2 SE images. T2*FE images were superior to T2 SE images in describing bone tumors as high-intensity areas or in delineating the tumors and adjacent soft-tissue. In most cases, T2*FE images were equal to T1 SE images in depicting bone lesions. T2*FE images could demonstrate some lesions which were not clearly detected on T1 SE images. On T2*FE images, a contrast-noise ratio (C/N) was calculated for each lesion. The value of C/N was helpful to distinguish vertebral tumors from benign compression fractures. In conclusion, T2*FE images together with T1 SE images are advantageous to evaluate bone lesions. (author)

1990-01-01

229

Eosinophilic granuloma of the temporal bone in children.  

Science.gov (United States)

Eosinophilic granuloma (EG) is a bony destructive disease that frequently occurs in children; it is a subtype of Langerhans cell histiocytosis. The aims of this study were to detect the presenting features of temporal bone lesions in children and to evaluate the efficacy of surgery combined with radiotherapy in treatment of the disease. A retrospective study on 12 children with EG of the temporal bone was done. Computed tomography and hearing assessment were performed for all patients. All patients were treated with cortical mastoidectomy followed by postoperative radiotherapy. Follow-up was carried out for at least 2 years. The patients' presenting symptoms were external ear canal mass in 10 patients (83.3%), postauricular swelling in 8 patients (66.7%), and persistent otorrhea in 4 patients (33.3%). Ten patients (83.3%) showed conductive hearing loss, whereas 2 patients (16.7%) showed mixed hearing loss on the affected side. Computed tomography showed osteolytic defects without sclerotic margins filled with soft tissue masses involving the mastoid bone. Histopathologic examination showed eosinophils and Langerhans cells that were immune reactive for CD1 antigen and S-100 protein. Postoperative follow-up showed complete cure of the disease in 10 children (83.3%), with recurrence detected in 2 patients (16.7%) who needed second surgical intervention. We concluded that temporal bone EG in children may present with features that mimic the features of chronic suppurative otitis media. However, computed tomography and histopathologic examination are diagnostic. Cortical mastoidectomy together with postoperative radiotherapy is an achievable treatment in most cases. PMID:24717312

Abdel-Aziz, Mosaad; Rashed, Mohammed; Khalifa, Badawi; Talaat, Ahmed; Nassar, Ahmed

2014-05-01

230

Spinal metastatic lesion in cancer patients. Investigation based on statistical analysis by bone scintigrams  

Energy Technology Data Exchange (ETDEWEB)

In a series of 2,216 cancer patients undergoing bone scintigraphy after diagnosis of the primary malignant tumor, 558 (25.2%) were found to have abnormal vertebral accumulation of radioactivity during the clinical course. Abnormal radioactivity in the vertebrae was frequently noted in patients with prostatic and renal cancer. The lumbar vertebrae were the most frequent sites but the cervical vertebrae were also affected with prostatic cancer, the thoracic vertebrae with lung and prostatic cancer, the lumbar vertebrae with breast and prostatic cancer and the sacral vertebrae with uterine cervical and prostatic cancer. Of the 558 patients with abnormal spinal radioactivity, 221 were examined by CT scan; the accumulated radioactivity was identified as a metastatic lesion in 170 patients (76.9%). Abnormal radioactivity was identified as a metastatic lesion most often in lung cancer patients. The CT-diagnosed metastases were classified into 3 types: sclerotic (51 patients, 30.0%), osteolytic (112, 65.9%), and mixed (46, 27.1%). The sclerotic type was relatively frequent in uterine cervical cancer, less frequent in lung cancer, and not seen in head and neck or renal cancer patients. The osteolytic type was relatively frequent in lung and renal cancer and less frequent in uterine cervical and prostatic cancer patients. Of the patients with CT-diagnosed vertebral metastasis, 87.3% survived for 3 months and 66.2% for 6 months after the detection of abnormal bone scintigraphy. Survival was shorter in patients with lung or gastrointestinal cancer than in those with other types of tumors. Since the pathology of vertebral metastasis of malignant tumors differs according to the primary lesion, the metastatic nature must be considered in the choice of treatment. (author).

Inoue, Takashi [Osaka Medical Coll., Takatsuki (Japan)

1995-12-01

231

Kinematics and thermodynamics of a growing rim of high-pressure phase  

Science.gov (United States)

We have reanalysed the problem of growth of a dense product rim on a sphere of parent phase. To decouple the problem of calculating deformation from rheology, we assume spherical symmetry, and incompressible phases. Within the product, the radial deviatoric strain and its time-derivative prove to be of opposite sign: strain is compressive, but the strain rate is tensile. Further, the radial deviatoric strain in the new product adjacent to the interface is invariant in time. Propagation of the phase interface is determined by a competition between two mechanisms: as an element of material is transformed, its shear strain energy is increased; and the core pressure performs work compressing it. For elastic phases, this competition results in metastability. Within a certain pressure range, either phase can occur alone, but the two phases can not coexist. Because this result is inconsistent with experiments by Kawazoe et al. (2010) in which a rim of high-pressure phase (wadsleyite) coexists with a central core of low-pressure phase (olivine), we then incorporate plastic flow. Assuming perfect plasticity, we show that for a given applied pressure exceeding the coexistence pressure, a rim of product can now nucleate if the excess pressure ?p exceeds a critical value depending on yield stress. Increasing ?p above this value allows product to grow into the parent phase. There are now two possibilities, depending on the value of ?p. Growth may eventually cease to produce a state in which the product rim is in equilibrium with a parent core; or growth may follow a more complicated path: within a range of excess pressures, the growth rate can decrease strongly from its initial value to produce a quasi-equilibrium state, before increasing again to a rate similar to that at which transformation began. We interpret these results to mean that if ?p is increased slowly in a series of experiments with constant yield stress, the sample passes through a series of equilibria until ?p is large enough for the second type of growth to be possible; transformation is then completed rapidly on the timescale set by interface kinetics. This result may be relevant to the problem of deep earthquakes. Lastly, using existing experiments in which a wadsleyite rim grows on an olivine sphere, we apply the theory to estimate the yield strength of wadsleyite: our estimates are consistent with measurements by independent methods.

Morris, S. J. S.

2014-03-01

232

The tectonic nature of the rim exposure of the Caspian valley lowlands. O tektonicheskoy prirode bortovogo ustupa Prikaspiyskoy vpadiny  

Energy Technology Data Exchange (ETDEWEB)

Based on an analysis of the geological and geophysical data and paleostructural structures, the tectonic nature of the rim escarpments surrounding the Caspian lowlands on the west, northwest and north is confirmed.

Slepakova, G.I.

1984-01-01

233

Clinical and biologic behavior of bone metastases from differentiated thyroid carcinoma  

Energy Technology Data Exchange (ETDEWEB)

Thirty (3.8%) of 780 patients with differentiated thyroid cancer seen between 1970 and 1987 had bone metastases. The primary tumor was follicular in 26 patients and papillary in four. Mean age at diagnosis was 61 years. The manifestation of bone metastases was the presenting symptom in 18 patients (60%). Treatment included total thyroidectomy, levothyroxine sodium therapy, and radioactive iodine treatments. Twenty-seven patients had bone metastases from the initial observation, with 44 sites involved. Of the sites, 27 (61%) were shown both on iodine 131 whole-body scan (WBS) and on x-ray film, 11 (25%) only on WBS, and six (14%) only on x-ray film. Multiple involvement was observed in 11 patients. The radiologic appearance was invariably osteolytic. Serum thyroglobulin was elevated in all patients. After radioactive iodine, no WBS+/X-ray+ metastases showed a complete response, although a sclerotic border was noted in several cases, whereas six WBS+/X-ray- lesions were no longer detectable by WBS. Treatment with radioactive iodine and bone surgery resulted in a complete cure in three patients and in a reduction of tumor mass in three. Twenty-one (70%) of the patients died of thyroid cancer after a mean survival of 86 months. Of the nine patients still alive, two are free of disease, three have a good quality of life, and four have severe disability.

Marcocci, C.; Pacini, F.; Elisei, R.; Schipani, E.; Ceccarelli, C.; Miccoli, P.; Arganini, M.; Pinchera, A. (Univ. of Pisa (Italy))

1989-12-01

234

Clinical and biologic behavior of bone metastases from differentiated thyroid carcinoma  

International Nuclear Information System (INIS)

Thirty (3.8%) of 780 patients with differentiated thyroid cancer seen between 1970 and 1987 had bone metastases. The primary tumor was follicular in 26 patients and papillary in four. Mean age at diagnosis was 61 years. The manifestation of bone metastases was the presenting symptom in 18 patients (60%). Treatment included total thyroidectomy, levothyroxine sodium therapy, and radioactive iodine treatments. Twenty-seven patients had bone metastases from the initial observation, with 44 sites involved. Of the sites, 27 (61%) were shown both on iodine 131 whole-body scan (WBS) and on x-ray film, 11 (25%) only on WBS, and six (14%) only on x-ray film. Multiple involvement was observed in 11 patients. The radiologic appearance was invariably osteolytic. Serum thyroglobulin was elevated in all patients. After radioactive iodine, no WBS+/X-ray+ metastases showed a complete response, although a sclerotic border was noted in several cases, whereas six WBS+/X-ray- lesions were no longer detectable by WBS. Treatment with radioactive iodine and bone surgery resulted in a complete cure in three patients and in a reduction of tumor mass in three. Twenty-one (70%) of the patients died of thyroid cancer after a mean survival of 86 months. Of the nine patients still alive, two are free of disease, three have a good quality of life, and four have severe disability

235

Pinhole bone scan mapping of metabolic profiles in osteoarthritis of the knee: a radiographic correlation  

International Nuclear Information System (INIS)

Osteoarthritis (OA) is mixture of damage to a joint and reaction induced therefrom. Heterogeneity, slow change and no proper means of assessing pathology make it a difficult disease to study. Diagnosis can be made by radiography when OA is established. But subtle metabolic change without radiographic alteration can only be detected by bone scan. Present study was performed to assess metabolic profiles of OA of the knee with various radiographic and preradiographic changes using pinhole bone scan (PBS). PBS and radiography were taken at the same time or a few days apart. We used single-head gamma camera and a 4-mm pinhole collimator. Patients were 9 men and 19 women (30-74 yr with mean being 55). PBS was correlated with radiography in each case. Increased tracer uptake was seen in 111 lesions in 28 knees. Intensity was arbitrarily graded into Grade 0-2. The results were divided into group with radiographic change (n=85; Table) and group without (n=26). Generally, tracer uptake was much intense in the sclerotic and cystic form. In radiographically normal group pathological uptake occurred mostly in subchondral bone (n=17) and some in the femoral condyle (n=9) denoting that subchondral bone is the most vulnerable. PBS is sensitive indicator of metabolic alternations in various disease processes of OA in both radiographically normal and abnormal cases

1999-11-19

236

Case report 391: Postradiation necrosis of bone (femur) with no evidence of tumour  

Energy Technology Data Exchange (ETDEWEB)

The case has been presented of a 21-year-old man who had been treated for Ewing tumor of the femur with local radiation and chemotherapy ten years previously. Significant increased uptake on the angiogram, blood pool studies and delayed imaging phases of the radionuclide scan was observed. This activity had increased dramatically from the bone scan obtained four years previously. Plain roentgenograms showed a mixed sclerotic and lytic lesion in the femur compatible with radionecrosis, recurrent Ewing tumor or radiation-induced osteosarcoma. Based on the findings of the bone scan a tumor was diagnosed and the patient underwent open biopsy. However, radiation osteonecrosis only was present; recurrent Ewing tumor or osteosarcoma was not observed. It may thus be stated that radiation can cause significant increase in uptake on serial bone scans even many years following radiation therapy. These features may simulate recurrent tumor or osteosarcoma. Thus, radionuclide bone scans, even many years after irradiation therapy, will not reliably differentiate between radiation-induced osteosarcoma, recurrent tumor or radiation osteonecrosis in patients who have been treated previously with radiation.

Datz, F.L.; Manaster, B.J.

1986-10-01

237

Bone Stress  

Science.gov (United States)

In this optics activity, learners examine how polarized light can reveal stress patterns in clear plastic. Learners place a fork between two pieces of polarizing material and induce stress by squeezing the tines together. Learners will observe the colored stress pattern in the image of the plastic that is projected onto a screen using an overhead projector. Learners rotate one of the polarizing filters to explore which orientations give the most dramatic color effects. This activity can be related to bones, as bones develop stress patterns from the loads imposed upon them every day.

Exploratorium, The

2011-12-07

238

Bone scans  

International Nuclear Information System (INIS)

This Atlas comes from a collection of 200 slides distributed by the ACOMEN. After covering the essentials of normal and pathological bone histology and physiology, the principles and technique of bone scans and normal aspects are presented. Comprehensive chapters of images illustrating the contribution of Nuclear medicine to osteoarticular pathology follow. At the end, a large section is devoted to pitfalls and artifacts. Even though this volume may be incomplete, it merits its existence; it constitutes a reference that everyone of us will be able to ase to improve his experience

1987-01-01

239

Feasibility and Safety of Transthoracic Echocardiography-Guided Transcatheter Closure of Atrial Septal Defects with Deficient Superior-Anterior Rims  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Although previous studies showed that transthoracic echocardiography (TTE) can be used to guide transcatheter closure of atrial septal defect (ASD), whether TTE can be used to guide transcatheter closure of secundum ASD with a deficient superior-anterior rim is unknown and this critical issue was addressed in the present study. A total of 280 patients with secundum ASD who underwent transcatheter ASD closure were recruited and divided into groups A and B depending on ASD superior-anterior rim...

Li, Gui-shuang; Li, Hai-de; Yang, Jie; Zhang, Wen-quan; Hou, Zong-shen; Li, Qing-chen; Zhang, Yun

2012-01-01

240

Physical and functional interaction between yeast Pif1 helicase and Rim1 single-stranded DNA binding protein  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Pif1 helicase plays various roles in the maintenance of nuclear and mitochondrial genome integrity in most eukaryotes. Here, we used a proteomics approach called isotopic differentiation of interactions as random or targeted to identify specific protein complexes of Saccharomyces cerevisiae Pif1. We identified a stable association between Pif1 and a mitochondrial SSB, Rim1. In vitro co-precipitation experiments using recombinant proteins indicated a direct interaction between Pif1 and Rim1. F...

Ramanagoudr-bhojappa, Ramanagouda; Blair, Lauren P.; Tackett, Alan J.; Raney, Kevin D.

2013-01-01

 
 
 
 
241

Development of high sensitive and reliable FFD and sodium leak detection technique for fast reactor using RIMS  

International Nuclear Information System (INIS)

The high sensitive fuel failure and sodium leak detection technique for fast reactors has been developed using laser resonance ionization mass spectrometry (RIMS) method. The RIMS is suitable for the isotope analysis of the element of ultra trace level, since there is no increase of the background by interfering ion and isobaric interference except for measuring element, because the measuring element is selectively ionized. The RIMS was applied to measure the artificially blended xenon and krypton gas (tag gas) which is used for the pressurized steel capsule of in-pile creep rupture experiment in the experimental fast reactor Joyo. This system can measure the tag gas isotopic ratios of about 100 ? 102 ppb level and the measured results could identify tag gas. The RIMS system can detect stable xenon nuclides and 133Xe in the sample of cover gas which was stored in the stainless steel container during the fuel failure simulation test in Joyo. The result shows the applicability of the RIMS system for assuming the burn-up of the failed fuel subassembly by the ratio of stable and radioactive xenon isotopes. The RIMS is then applied to detect a small amount of sodium leaks from the fast reactor cooling system. In case of detecting sodium isotopes using RIMS, the aerodynamic lens was newly introduced, which can transfer aerosols at atmospheric pressure into a vacuum chamber while increasing the aerosol density at the same time. We performed the experiments using stable isotope 23Na to evaluate the detection sensitivity of the prototype system. The preliminary test results showed that prototype system could easily detect sodium aerosol of 2.7 ppt, of which sensitivity is 400 times higher than the conventional sodium leak detectors currently used. The RIMS system is expected to be a promising innovative instrumentation system not only for Monju, but also for the future sodium cooled fast reactors. (author)

2012-03-01

242

Metastatic Bone Disease  

Science.gov (United States)

... American Academy of Orthopaedic Surgeons. MBD vs. Primary Bone Cancer The diagnosis of metastatic bone disease should not ... from an unknown primary carcinoma or a primary bone cancer (sarcoma). For example, if an area of bone ...

243

Bone loss. Epidemiology of bone loss.  

Science.gov (United States)

Bone loss occurs when the cellular events of bone formation are quantitatively larger than bone formation. This manuscript discusses the measurement of bone loss, occurrence in the population, risk factors and consequences of bone loss. Recent developments in bone mass measurement and biomarkers have improved our ability to assess bone loss. This process is a normal concomitant of ageing. There are a number of other risk factors, including sex hormone deficiency, physical inactivity, calcium/vitamin D deficiency, inflammatory arthritis, corticosteroids, smoking and alcohol. The major consequence of bone loss in our ageing society is fracture. PMID:11094456

Hunter, D J; Sambrook, P N

2000-01-01

244

Bone loss: Epidemiology of bone loss  

Science.gov (United States)

Bone loss occurs when the cellular events of bone formation are quantitatively larger than bone formation. This manuscript discusses the measurement of bone loss, occurrence in the population, risk factors and consequences of bone loss. Recent developments in bone mass measurement and biomarkers have improved our ability to assess bone loss. This process is a normal concomitant of ageing. There are a number of other risk factors, including sex hormone deficiency, physical inactivity, calcium/vitamin D deficiency, inflammatory arthritis, corticosteroids, smoking and alcohol. The major consequence of bone loss in our ageing society is fracture.

Hunter, David J; Sambrook, Philip N

2000-01-01

245

Broken bone  

Science.gov (United States)

... DO NOT move the person if a head, neck, or back injury is suspected. CHECK BLOOD CIRCULATION Check the person's ... is a suspected broken bone in the head, neck, or back. There is a ... immobilize the injury at the scene by yourself. There is severe ...

246

Bone Densitometry  

Medline Plus

Full Text Available ... as bed rest, weakens the bones. A diet low in dairy products and calcium can make osteoporosis worse. Smoking and excessive use of alcohol tend to also make osteoporosis worse. Sustained exercise, such as running marathons, decreases the levels of estrogen in the blood and may predispose ...

247

Bone scintiscanning  

International Nuclear Information System (INIS)

The authors present in detail the foundations and techniques of bone scintigraphy. Scintigraphic semiology in joint diseases is considered in full. Finally the limits and indications of this technique, which concerns many branches: rheumatology, cancerology, hematology, nephrology, traumatology, orthopedics, are outlined

1980-05-17

248

Detection of bone metastases in patients with prostate cancer by {sup 18}F fluorocholine and {sup 18}F fluoride PET-CT: a comparative study  

Energy Technology Data Exchange (ETDEWEB)

The aim of this prospective study was to compare the potential value of {sup 18}F fluorocholine (FCH) and {sup 18}F fluoride positron emission tomography (PET)-CT scanning for the detection of bony metastases from prostate cancer. Thirty-eight men (mean age, 69{+-}8 years) with biopsy-proven prostate cancer underwent both imaging modalities within a maximum interval of 2 weeks. Seventeen patients were evaluated preoperatively, and 21 patients were referred for post-operative evaluation of suspected recurrence or progression based on clinical algorithms. The number, sites and morphological patterns of bone lesions on {sup 18}F FCH and {sup 18}F fluoride PET-CT were correlated: Concordant lesions between the two modalities with corresponding changes on CT were considered to be positive for malignancy; discordant lesions were verified by follow-up examinations. The mean follow-up interval was 9.1 months. Overall, 321 lesions were evaluated in this study. In a lesion-based analysis, a relatively close agreement was found between these two imaging modalities for detection of malignant bone lesions (kappa=0.57), as well as in a patient-based analysis (kappa=0.76). Sixteen malignant sclerotic lesions with a high density were negative in both {sup 18}F FCH and {sup 18}F fluoride PET-CT [ mean Hounsfield unit (HU), 1,148{+-}364]. There was also a significant correlation between tracer intensity by SUV and density of sclerotic lesions by HU both in {sup 18}F FCH PET-CT (r=-0.28, p<0.006) and {sup 18}F fluoride PET-CT (r=-0.20, p<0.05). The sensitivity, specificity and accuracy of PET-CT in the detection of bone metastases in prostate cancer was 81%, 93% and 86% for {sup 18}F fluoride, and 74% (p=0.12), 99% (p=0.01) and 85% for FCH, respectively. {sup 18}F FCH PET-CT led to a change in the management in two out of 38 patients due to the early detection of bone marrow metastases. {sup 18}F fluoride PET-CT identified more lesions in some patients when compared with {sup 18}F FCH PET-CT but did not change patient management. FCH PET-CT may be superior for the early detection (i.e. bone marrow involvement) of metastatic bone disease. In patients with FCH-negative suspicious sclerotic lesions, a second bone-seeking agent (e.g. {sup 18}F fluoride) is recommended. {sup 18}F fluoride PET-CT demonstrated a higher sensitivity than {sup 18}F FCH PET-CT, but the difference was not statistically significant. Furthermore, {sup 18}F fluoride PET could be also negative in highly dense sclerotic lesions, which presumably reflects the effect of treatment. It will be important to clarify in future studies whether these lesions are clinically relevant when compared with metabolically active bone metastases. (orig.)

Beheshti, Mohsen; Vali, Reza; Fitz, Friedrich; Nader, Michael; Langsteger, Werner [St. Vincent' s Hospital, Nuclear Medicine and Endocrinology, PET-CT Center LINZ, Linz, Uperaustria (Austria); Waldenberger, Peter [St. Vincent' s Hospital, Radiology, Linz (Austria); Loidl, Wolfgang; Stoiber, Franz [St. Vincent' s Hospital, Urology, Linz (Austria); Broinger, Gabriele [St. Vincent' s Hospital, Pathology, Linz (Austria); Foglman, Ignac [Guy' s and St. Thomas' NHS Foundation Trust, Nuclear Medicine, London (United Kingdom)

2008-10-15

249

The Enigmatic Bench Unit of Endeavour Crater Rim in Meridiani Planum, Mars  

Science.gov (United States)

For the first 2680 sols of its mission, the Mars Exploration Rover Opportunity traversed across essentially the same rocks: sulfur-rich sandstones known as the Burns formation. On August 8, 2011 Opportunity completed a ~21 km traverse from Victoria crater to the rim of the ~22 km diameter Endeavour crater where it crossed a slightly raised smooth bench unit that surrounds an interior core of higher standing and more rugged terrain on a rim segment named Cape York. As recognized by its distinctive morphologic character evident in orbital images, the inward sloping bench feature is found associated with portions of other segments of the discontinuous raised rim of Endeavour crater. Viewed by Opportunity, it appears as platy, fractured, relatively light-toned outcrop that is fine-grained, lacks hematite concretions and in places hosts veins of Ca- and S-rich composition, likely due to precipitation of gypsum in fractures that cut the bench unit (1). The bench outcrop target named Grasberg included a grind using the Rock Abrasion Tool (RAT) to obtain a cleaner surface for the Alpha Particle X-ray Spectrometer chemistry measurement compared with the initially investigated target named Deadwood. In addition to its greater strength than Burns formation as determined by the RAT grind operation, Grasberg and other examples of the bench unit have lower S, higher Cl and other elemental characteristics that depart from typical Burns formation. Thus the 'Grasberg unit' clearly represents a distinct rock type compared to the Meridiani plains. A second unit makes up the exposed core of the Cape York rim segment. Known as Shoemaker formation, it is composed of breccias that are recognized as a suevite deposit produced from the Endeavour impact event (1). The Shoemaker formation appears to be onlapped by the Grasberg unit with Burns formation onlapping it (1). However, a well-exposed section observed in a wedge-shaped fracture known as Whim Creek on the northeast portion of the Cape York bench clearly presents Grasberg rocks above Burns rocks. Erosion of a plunging synclinal form could explain this apparent inverted relationship, or it reveals that the Grasberg unit is younger than Burns formation. But this latter interpretation implies that Grasberg rocks, which have been observed only at the Endeavour rim, have been stripped off of Burns formation everywhere else. The Grasberg bench unit has recently been encountered in an isthmus setting between two low knobs of presumed Shoemaker formation called Nobbys Head and Sutherland Point just south of Cape York. The isthmus also presents Grasberg as topographically elevated above the Burns formation rocks. Despite its broad, smooth exposure, no remnants of Burns formation have been found on top of Grasberg at this location or anywhere on the Cape York bench. So the stratigraphic relationship between Grasberg and Burns rocks remains enigmatic. At the time of writing, Opportunity is at the edge of Solander Point, another bench feature on the northern tip of a rim segment known as Cape Tribulation. The erosional expression of this example appears different from those examined previously and perhaps offers the best chance to understand stratigraphic relationships. 1. S. W. Squyres et al., Ancient impact and aqueous processes at Endeavour Crater, Mars. Science 336, 570 (2012).

Ruff, S. W.

2013-12-01

250

Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The autophagic vacuolar myopathies (AVM are a group of inherited myopathies defined by the presence of autophagic vacuoles in pathological muscle specimens. AVM can be categorized into three groups: acid maltase deficiency, myopathies characterized by autophagic vacuoles with unique sarcolemmal features, and rimmed vacuolar myopathies (RVM. While the pathogeneses of these conditions are still being elucidated, some drugs (e.g., chloroquine, its analog, hydroxychloroquine, and colchicine can also cause AVM. Minocycline is a disease-modifying anti-rheumatic drug that may be used in the treatment of rheumatoid arthritis (RA. Here, we describe the first case of minocycline-associated AVM with rimmed vacuole formation. Case presentation A 75-year-old woman suffering from RA has been continuously treated with minocycline (200 mg/day for the past 7 years. During this time, she developed a myopathy that predominantly affected her lower limbs. Histological studies of biopsied muscle revealed scattered atrophic myofibers with rimmed vacuoles that contained pigment granules. Histochemical staining revealed that the pigment comprised both iron and melanin, which is consistent with type II minocycline-induced cutaneous pigmentation. Under electron microscopy, autophagic vacuoles were consistently observed in association with numerous collections of pigment granules. Conclusions This is the first report of minocycline-induced pigmentation in skeletal muscle. The strong association between autophagic vacuoles and the accumulation of minocycline-induced pigments suggest that long-term minocycline treatment induced pigment accumulation, leading to elevation of autophagic activity and RVM. It might also be possible that minocycline directly activated autophagy, as the observed pigments are known to form complexes containing minocycline and/or its metabolites. As long-term minocycline treatment is expected to be used more widely in the future, we must draw attention to this adverse effect.

Bokuda Kota

2012-11-01

251

RIMS: An Integrated Mapping and Analysis System with Applications to Earth Sciences and Hydrology  

Science.gov (United States)

A web-based information and computational system for analysis of spatially distributed Earth system, climate, and hydrologic data have been developed. The System allows visualization, data exploration, querying, manipulation and arbitrary calculations with any loaded gridded or vector polygon dataset. The system's acronym, RIMS, stands for its core functionality as a Rapid Integrated Mapping System. The system can be deployed for a Global scale projects as well as for regional hydrology and climatology studies. In particular, the Water Systems Analysis Group of the University of New Hampshire developed the global and regional (Northern Eurasia, pan-Arctic) versions of the system with different map projections and specific data. The system has demonstrated its potential for applications in other fields of Earth sciences and education. The key Web server/client components of the framework include (a) a visualization engine built on Open Source libraries (GDAL, PROJ.4, etc.) that are utilized in a MapServer; (b) multi-level data querying tools built on XML server-client communication protocols that allow downloading map data on-the-fly to a client web browser; and (c) data manipulation and grid cell level calculation tools that mimic desktop GIS software functionality via a web interface. Server side data management of the system is designed around a simple database of dataset metadata facilitating mounting of new data to the system and maintaining existing data in an easy manner. RIMS contains "built-in" river network data that allows for query of upstream areas on-demand which can be used for spatial data aggregation and analysis of sub-basin areas. RIMS is an ongoing effort and currently being used to serve a number of websites hosting a suite of hydrologic, environmental and other GIS data.

Proussevitch, A. A.; Glidden, S.; Shiklomanov, A. I.; Lammers, R. B.

2011-12-01

252

Search for triggered star formation in the unique bright rimmed cloud 4  

Science.gov (United States)

In order to further our understanding of the radiation driven implosion (RDI) processes and provide an observational feedback to the theoretical modelling of these processes for a wide range of parameters, we propose to search for and study triggered star formation in the highly under-pressured with respect to its ionized boundary layer and one of the smallest among the known cataloged bright rimmed clouds (BRCs), BRC 4. The data and science analyses similar to those applied in our study of the BRC 38 (= IC 1396N) will be employed.

Garmire, Gordon

2007-09-01

253

Tumor misto do rim com estrutura de Miosarcoma Mipernefroma e blastema renal em individuo adulto  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O A. descreve um caso de turmor misto do rim, em indivíduo do sexo masculino, com 58 anos de idade. A doença teve evolução lenta, somente sendo suspeitada, quando atingiu a fase final. O exame necroscópico revelou a existência de volumoso tumor do rim direito, apresentando forma bosselada, medindo 1 [...] 9 x 10 x 10 cm e pesando 940 g. A massa tumoral destrói quase completamente a estrutura renal, desta pouca restando reconhecivel. Fora do rim, encontra-se tambem tecido blastomatoso no figado, nos gânglios linfáticos mesentéricos, no peritônio e no epiploon. A estrutura do tumor, observada nos cortes histológicos, é variavel conforme o tecido examinado: no rim hipernefroma; fígado, gãnglios linfáticos, nos nódulos do peritônio e do epiploon, sarcoma mioblástico; em alguns gânglios do mesentério, alem da estrutura de sarcoma mioblástico, existe tecido nefrógeno, representado por formações pouco numerosas, constituidas por túbulos epiteliais, reproduzindo a estrutura de túbulo urinífero. casos desta natureza teem sido referidos com particular raridade, muito se aproximando o caso estudado do descrito por CHEVREL-BODIN e MARUELLE. Abstract in english The A. describes a case of mixed tumor of the kidney in a 58-year-old male individual. The disease underwent a slow evolution, only being suspected when it attained its final stage. The post mortem examination revealed the presence of a bulky tumor of the right kidney, of a bosselated surface, measu [...] ring 19 x 10 x 10 cms. and 940 grs. in weigtht. The tumoral mass destroys the whole kidney structure, of which but very little of recognizable tissue is left. Outside the kidney, blastomatous tissue is also met with in the liver, mesenteric lymphatic glands, peritoneum and apiploon. The tumor structura observed on histological section, varies in conformity with the tissue examined: hipernephroma in the kidney; myoblastic sarcoma in the liver, lymphatic glands, nodules of the peritoneum and epiploon; in some mesenteric glands, apart from the myoblasto-sarcomatous structure, there is nephrogenic tissue, represented by infrequent formations made up epithelial tubules reproducing the structure of uriniferous tubules. Cases of such a feature have been reported as being of particular rarity, and the case here studied approaches very much that described by CHEVREL-BODIN and MARUELLE.

A. Penna de, Azevedo.

254

A bright-rimmed cloud sculpted by the H ii region Sh2-48  

Science.gov (United States)

Aims: We characterize a bright-rimmed cloud embedded in the H ii region Sh2-48 while searching for evidence of triggered star formation. Methods: We carried out observations towards a region of 2' × 2' centered at RA = 18h22m11.39s, Dec = -14°35'24.81''(J2000) using the Atacama Submillimeter Telescope Experiment (ASTE; Chile) in the 12CO J = 3-2, 13CO J = 3-2, HCO+J = 4-3, and CS J = 7-6 lines with an angular resolution of about 22''. We also present radio continuum observations at 5 GHz carried out with the Jansky Very Large Array (JVLA; EEUU) interferometer with a synthetized beam of 7'' × 5''. The molecular transitions were used to study the distribution and kinematics of the molecular gas of the bright-rimmed cloud. The radio continuum data was used to characterize the ionized gas located on the illuminated border of this molecular condensation. Combining these observations with infrared public data allowed us to build up a comprehensive picture of the current state of star formation within this cloud. Results: The analysis of our molecular observations reveals a relatively dense clump with n(H2) ~ 3 × 103cm-3, located in projection onto the interior of the H ii region Sh2-48. The emission distribution of the four observed molecular transitions has, at VLSR ~ 38 km s-1, morphological anticorrelation with the bright-rimmed cloud as seen in the optical emission. From the new radio continuum observations, we identify a thin layer of ionized gas located on the border of the clump that is facing the ionizing star. The ionized gas has an electron density of about 73 cm-3, which is a factor three higher than the typical critical density (nc ~ 25 cm-3), above which an ionized boundary layer can be formed and maintained. This supports the hypothesis that the clump is being photoionized by the nearby O9.5V star, BD-14 5014. From the evaluation of the pressure balance between the ionized and molecular gas, we conclude that the clump would be in a prepressure balance state with the shocks being driven into the surface layer. Among the five YSO candidates found in the region, two of them (class I) are placed slightly beyond the bright rim, suggesting that their formation could have been triggered by the radiation-driven implosion process.

Ortega, M. E.; Paron, S.; Giacani, E.; Rubio, M.; Dubner, G.

2013-08-01

255

Notes on the uwainat oil rim development, Maydan Mahzam and Bul Hanine Fields, offshore Qatar  

Energy Technology Data Exchange (ETDEWEB)

As a result of reservoir simulation studies of the Uwainat reservoirs (Maydan Mahzam and Bul Hanine Fields), drilling to the Uwainat oil rim target became very ''tight'' with a very limited vertical tolerance. To achieve drilling to the tight target requires a precise position of the well at the top of the Lower Arab IV reservoir (a reliable marker) and an accurate isochore of the Lower Arab IV - Uwainat. The discussion shows that the level of accuracy needed in determining both the actual subsea well position and in constructing the depth contours of the reservoirs is extremely high.

Hamam, K.A.

1985-03-01

256

Positron emission tracking of individual particles in particle-laden rimming flow  

Science.gov (United States)

The motion of a single tracer particle in particle-laden rimming flows is investigated experimentally by means of Positron Emission Particle Tracking (PEPT). Semi-dilute suspensions, with a volume fraction of 8% of heavy particles are considered. The trajectory of the tracer particle is monitored for several thousand cylinder revolutions and related to the optically recorded drift of the large-scale granular segregation bands developing in the cylinder. Results of the data analysis provide first insights into the relation between behaviour of individual particles and the spatiotemporal dynamics displayed by the macroscopic particle-segregation patterns.

Denissenko, P.; Guyez, E.; Thomas, P. J.; Parker, D. J.; Seville, J. P. K.

2014-05-01

257

Ultratrace determination of the long-lived isotope [sup 41]Ca by narrowband CW-RIMS  

Energy Technology Data Exchange (ETDEWEB)

Determination of odd isotopes with multi-step RIMS is usually hampered by the hyperfine structure arising from a non zero nuclear spin. The splitting of the transition strength leads to a reduced ionization efficiency and large uncertainties in the determination of isotope ratios. We present a technique to overcome these drawbacks by appropriate use of optical pumping. Applying this technique, first isotopic ratio measurements on synthetic [sup 41]Ca-samples could be accomplished using double-resonance three photon ionization in a collimated atomic beam combined with a quadrupole mass spectrometer. [copyright] [ital 1998 American Institute of Physics.

Muller, P.; Blaum, K.; Nortershauser, W.; Wendt, K. (Institut fuer Physik, Johannes Gutenberg-Universitaet, D-55099 Mainz (Germany)) Trautmann, N. (Institut fuer Kernchemie, Johannes Gutenberg-Universitaet, D-55099 Mainz (Germany)) Bushaw, B.A. (Pacific Northwest National Laboratory, Richland, Washington 99352 (United States))

1998-12-01

258

Ultratrace determination of the long-lived isotope {sup 41}Ca by narrowband CW-RIMS  

Energy Technology Data Exchange (ETDEWEB)

Determination of odd isotopes with multi-step RIMS is usually hampered by the hyperfine structure arising from a non zero nuclear spin. The splitting of the transition strength leads to a reduced ionization efficiency and large uncertainties in the determination of isotope ratios. We present a technique to overcome these drawbacks by appropriate use of optical pumping. Applying this technique, first isotopic ratio measurements on synthetic {sup 41}Ca-samples could be accomplished using double-resonance three photon ionization in a collimated atomic beam combined with a quadrupole mass spectrometer. {copyright} {ital 1998 American Institute of Physics.}

Muller, P.; Blaum, K.; Nortershauser, W.; Wendt, K. [Institut fuer Physik, Johannes Gutenberg-Universitaet, D-55099 Mainz (Germany)] Trautmann, N. [Institut fuer Kernchemie, Johannes Gutenberg-Universitaet, D-55099 Mainz (Germany)] Bushaw, B.A. [Pacific Northwest National Laboratory, Richland, Washington 99352 (United States)

1998-12-01

259

Ultratrace determination of the long-lived isotope 41Ca by narrowband CW-RIMS  

International Nuclear Information System (INIS)

Determination of odd isotopes with multi-step RIMS is usually hampered by the hyperfine structure arising from a non zero nuclear spin. The splitting of the transition strength leads to a reduced ionization efficiency and large uncertainties in the determination of isotope ratios. We present a technique to overcome these drawbacks by appropriate use of optical pumping. Applying this technique, first isotopic ratio measurements on synthetic 41Ca-samples could be accomplished using double-resonance three photon ionization in a collimated atomic beam combined with a quadrupole mass spectrometer

1998-12-16

260

Radioisotopic measurement methods for determining the wear railway brake shoe and its rim wearing effect  

International Nuclear Information System (INIS)

Under operating conditions the wear of brake shoe was tested by a measuring method based on the principle of radioisotopic thickness measurement. It is characteristic to the sensitivity of the method that the wear caused by the fast braking of a train (speed: 100 km/h) as well as the uneven wear distribution were determinable. Surface activating methods assuring the periodic and continuous evaluation were also developed. A test was performed with galvanic surface activation under operating conditions to determine the rim wearing effect of the brake shoe. Apart from the operational tests a new method based on activated wear measurement was also developed. (author)

1979-01-01

 
 
 
 
261

Improvements in RIMS isotope precision : applications to in situ atom-limited isotopic analysis.  

Energy Technology Data Exchange (ETDEWEB)

Resonance ionization mass spectrometry offers high sensitivity and elemental selectivity in microanalysis, but the isotopic precision attainable by this technique has been limited. Here we report instrumental modifications to improve the precision of RIMS isotope ratio measurements. Special attention must be paid to eliminating pulse-to-pulse variations in the time-of-flight mass spectrometer through which the photoions travel, and resonant excitation schemes must be chosen such that the resonance transitions can be substantially power-broadened to cover the isotope shifts. We report resonance ionization measurements of chromium isotope ratios with statistics-limited precision better than 1%.

Levine, J.; Savina, M.; Stephan, T.; Pellin, M. (Materials Science Division); (Univ.of Chicago); (Chicago Center for Cosmochemistry)

2009-03-01

262

Improvements in RIMS Isotopic Precision: Application to in situ atom-limited analyses  

International Nuclear Information System (INIS)

Resonance ionization mass spectrometry offers high sensitivity and elemental selectivity in microanalysis, but the isotopic precision attainable by this technique has been limited. Here we report instrumental modifications to improve the precision of RIMS isotope ratio measurements. Special attention must be paid to eliminating pulse-to-pulse variations in the time-of-flight mass spectrometer through which the photoions travel, and resonant excitation schemes must be chosen such that the resonance transitions can substantially power-broadened to cover the isotope shifts. We report resonance ionization measurements of chromium isotope ratios with statistics-limited precision better than 1%.

2009-03-17

263

First synthesis of upper rim mono and dinitrone calix[4]arene derivatives  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract A new class of calix[4]arene derivatives bearing one or two nitrone groups on the upper rim has been synthesized using the oxidation of chiral imines with hydrogen peroxide. The imine intermediates were obtained via amination of the diformyl derivative. The 1H NMR spectra and X-ray data indicated a 1,3-disubstituted cone conformation for the imine derivatives and the existence of a single (E,E) isomer. The structural identity of the nitrone derivatives was confirmed from N...

2007-01-01

264

Bone scanning  

International Nuclear Information System (INIS)

A survey of nine Atlanta area hospitals, each with over 200 beds revealed that in the years 1970 through 1972 most hospitals were performing 10 to 30 bone scans annually. There was a dramatic increase to 100 to 200 bone scans in 1973 and a continued increase to 200 to 500 in 1974. Although the 1975 figures are not yet complete it appears four hospitals will be over 500 and Emory University Hospital will be over 1000 bone scans. The sudden increase in utilization of bone scans in 1973 can be attributed to the introduction of /sup 99m/Tc-polyphosphate in July 1972. Two previous radiopharmaceuticals had been used, Strontium-85 and Fluorine-18. The beta particle radiation dosage from 85Sr was so high that the Atomic Energy Commission would allow its use only in cancer patients or in patients with a strong likelihood of cancer. Another detriment to 85Sr was its slow, colonic excretion necessitating cleansing enemas and a four to five day delay in scanning. Although 18F was excreted quickly via the urinary tract which obviated the enemas and the delay in scanning, it had a high cost and a mere two hour half-life. Since the only source of intravenous 18F was in California, only cities with direct air routes to San Francisco could hope to obtain it. Several times we had to cancel our patients anyway due to ''shipping difficulties.'' We then attempted to obtain non-pyrogen free material from the Georgia Tech Reactor and give the radionuclide orally but this often resulted in a large accumulation of the tracer in the stomach which obscured uptake in the lower thoracic-upper lumbar spine

1975-01-01

265

Proteomics in bone research  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Osteoporosis is prevalent among the elderly and is a major cause of bone fracture in this population. Bone integrity is maintained by the dynamic processes of bone resorption and bone formation (bone remodeling). Osteoporosis results when there is an imbalance of the two counteracting processes. Bone mineral density, measured by dual-energy x-ray absorptiometry has been the primary method to assess fracture risk for decades. Recent studies demonstrated that measurement of bone turnover marker...

Zhang, Hengwei; Recker, Robert; Lee, Wai-nang Paul; Xiao, Gary Guishan

2010-01-01

266

Review of psychiatric services to mentally disordered offenders around the Pacific Rim.  

Science.gov (United States)

This article was commissioned to collate and review forensic psychiatric services provided in a number of key Pacific Rim locations in the hope that it will assist in future dialogue about service development. The Board of the Pacific Rim College of Psychiatrists identified experts in forensic psychiatry from Australia, Canada, China, Hong Kong, Japan, Russia, Singapore, Taiwan, and the US. Each contributor provided an account of issues in their jurisdiction, including mental health services to mentally disordered offenders in prison, competence or fitness to stand trial, legal insanity as a defense at trial, diminished responsibility, and special forensic services available, including forensic hospitals and community forensic mental health services. Responses have been collated and are presented topic by topic and country by country within the body of this review. The availability of mental health screening and psychiatric in-reach or forensic liaison services within prisons differed considerably between countries, as did provisioning of community forensic mental health and rehabilitation services. Diversion of mentally disordered offenders to forensic, state, or hybrid hospitals was common. Legal constructs of criminal responsibility (insanity defense) and fitness to stand trial ("disability") are almost universally recognized, although variably used. Disparities between unmet needs and resourcing available were common themes. The legislative differences between contributing countries with respect to the mental health law and criminal law relating to mentally disordered offenders are relatively subtle. The major differences lie in operationalizing and resourcing forensic services. PMID:24249353

Every-Palmer, Susanna; Brink, Johann; Chern, Tor P; Choi, Wing-Kit; Hern-Yee, Jerome Goh; Green, Bob; Heffernan, Ed; Johnson, Sarah B; Kachaeva, Margarita; Shiina, Akihiro; Walker, David; Wu, Kevin; Wang, Xiaoping; Mellsop, Graham

2014-03-01

267

A Radio and Mid-Infrared Survey of Northern Bright-Rimmed Clouds  

CERN Document Server

We have carried out an archival radio, optical and infrared wavelength imaging survey of 44 Bright-Rimmed Clouds (BRCs) using the NRAO/VLA Sky Survey (NVSS) archive, images from the Digitised Sky Survey (DSS) and the Midcourse Space eXperiment (MSX). The data characterise the physical properties of the Ionised Boundary Layer (IBL) of the BRCs. A total of 25 clouds display 20 cm radio continuum emission that is associated with their bright optical rims. The ionising photon flux illuminating these clouds, the ionised gas pressure and the electron density of the IBL are determined. We derive internal molecular pressures for 9 clouds using molecular line data from the literature and compare these pressures to the IBL pressures to determine the pressure balance of the clouds. We find three clouds in which the pressure exerted by their IBLs is much greater than that measured in the internal molecular material. A comparison of external pressures around the remaining clouds to a global mean internal pressure shows th...

Morgan, L K; Urquhart, J S; Miao, G J; Miao, Glenn.J.White & J.

2001-01-01

268

X-ray Proper Motions and Shock Speeds along the Northwest Rim of SN 1006  

CERN Multimedia

We report the results of an X-ray proper motion measurement for the NW rim of SN1006, carried out by comparing Chandra observations from 2001 and 2012. The NW limb has predominantly thermal X-ray emission, and it is the only location in SN1006 with significant optical emission: a thin, Balmer-dominated filament. For most of the NW rim, the proper motion is about 0.30 arcsec/yr, essentially the same as has been measured from the H-alpha filament. Isolated regions of the NW limb are dominated by nonthermal emission, and here the proper motion is much higher, 0.49 arcsec/yr, close to the value measured in X-rays along the much brighter NE limb, where the X-rays are overwhelmingly nonthermal. At the 2.2 kpc distance to SN1006, the proper motions imply shock velocities of about 3000 km/s and 5000 km/s in the thermal and nonthermal regions, respectively. A lower velocity behind the H-alpha filament is consistent with the picture that SN1006 is encountering denser gas in the NW, as is also suggested by its overall m...

Katsuda, Satoru; Petre, Robert; Reynolds, Stephen P; Williams, Brian J; Winkler, P Frank

2012-01-01

269

Ultratrace analysis of plutonium in environmental samples by resonance ionization mass spectrometry (RIMS)  

Science.gov (United States)

Plutonium is present in the environment mainly as a result of global fallout from nuclear weapons tests, satellite and reactor accidents as well as releases from nuclear facilities. Sensitive and fast detection methods are required for risk assessment, low-level surveillance of the environment, personnel dose monitoring, studies of biological effects and investigations of the migration behavior of plutonium. Furthermore, the isotopic composition is of interest to get information from what source the plutonium contamination originated. Alpha-spectroscopy is most frequently used for the determination of trace amounts of plutonium in the environment with the disadvantage that the detection sensitivity depends on the half-life of the isotope to be measured and that there are limitations in the isotopic resolution. Conventional mass spectrometry may suffer from isobaric interferences. Therefore, in the last years resonant laser ionization mass spectrometry (RIMS) has been explored as an alternative for ultratrace analysis of plutonium. This method provides a high element and isotope selectivity and a good overall efficiency, resulting in a detection limit of ~106 atoms (~0.4 fg). RIMS meets also the requirements of a low background and a short measuring time (1-2 h). .

Trautmann, N.; Erdmann, N.; Grüning, C.; Kratz, J. V.; Waldek, A.; Huber, G.; Nunnemann, M.; Passler, G.

2000-07-01

270

Analysis of physical processes affecting restructuring of UO_2 fuel in Rim-zone  

International Nuclear Information System (INIS)

The purpose of the presented paper is the analysis of the processes affecting so-called 'rim-zone' formation in UO_2 and the development of the model describing isotope content profiles at extended burnup. The influence of rim-zone and extended burnup on fuel temperatures is also considered. A brief review of the worldwide models for fission rate and isotope content profiles at extended burnup is given. In this frame, a new model for for prediction of radial profiles of burnup, fission rate and plutonium isotopes have been developed in the TRINITY (Russia). The results from the comparison of the model predictions with experimental data show that the model has good predictability. A new model describing the conditions of dislocation loop nucleation from interstitial atom clusters on fission spikes is also proposed in this paper. The results of the model show that the fuel grain diameter significantly affects the concentration of point defects and dislocation loops. The paper presents the results from the RTOP code calculations of fuel temperature, taking into account non-uniform fission rate and thermal conductivity degradation as result of burnup increasing

2001-10-01

271

Definition imaging of an orebody with the radio imaging method (RIM)  

Energy Technology Data Exchange (ETDEWEB)

Waste rock dilution is an economic concern in the planning and design of mining methods for mineralized ore zones. Diamond core drilling and mineralogical examination of core are routinely used to determine the general shape of the ore body. Drilling on closer centers enhances the definition of the mineralization and oregrade across the orebody. In a practical sense, drilling time and cost limit definition. Crosshole scanning between drillholes with the radio imaging method (RIM) has been used to map changes in mineralization in the rock mass. The magnitude and phase of the RIM radio wave depend on the electrical conductivity of the rock mass. The conductivity strongly depends on the percent mineralization. Since the attenuation rate and phase constants of the radio wave are proportional to the one half power of conductivity, the measured crosshole radio wave data can be processed in a tomography algorithm to reconstruct images (map the change in conductivity (mineralization)). The tomography image enhances definition in the orebody while reducing the number of drillholes. This paper compares reconstructed images of the radio wave propagation constants to percent mineralization in the ore body.

Stolarczyk, L.G. (Stolar, Inc., Raton, NM (United States))

1992-10-01

272

Definition imaging of an orebody with the radio imaging method (RIM)  

International Nuclear Information System (INIS)

Waste rock dilution is an economic concern in the planning and design of mining methods for mineralized ore zones. Diamond core drilling and mineralogical examination of core are routinely used to determine the general shape of the ore body. Drilling on closer centers enhances the definition of the mineralization and oregrade across the orebody. In a practical sense, drilling time and cost limit definition. Crosshole scanning between drillholes with the radio imaging method (RIM) has been used to map changes in mineralization in the rock mass. The magnitude and phase of the RIM radio wave depend on the electrical conductivity of the rock mass. The conductivity strongly depends on the percent mineralization. Since the attenuation rate and phase constants of the radio wave are proportional to the one half power of conductivity, the measured crosshole radio wave data can be processed in a tomography algorithm to reconstruct images (map the change in conductivity (mineralization)). The tomography image enhances definition in the orebody while reducing the number of drillholes. This paper compares reconstructed images of the radio wave propagation constants to percent mineralization in the ore body

1992-10-01

273

The GT-MHR - clear, economic, and safe power for the Pacific Rim  

International Nuclear Information System (INIS)

In recent decades the nations of the Pacific Rim have outpaced the rest of the world in economic growth. Beyond an abundant labor market and the region's natural resources, energy has played a pivotal role in fuelling this boom. The diverse sources of this energy largely reflect the naturally occurring fuel assets in the Rim countries. Only in the countries where these resources are less plentiful has nuclear energy become a significant sources of electric power generation. Persuasive as the argument for non-polluting power may be by itself it does not sell the nuclear energy option. In addition to being clean it must also be economically competitive and very safe. The authors claim that the Gas-Turbine Modular Helium Reactor (GT-MHR) is an advances nuclear power system that addresses the issues, and should be viewed as an attractive candidate to meet future energy needs. The GT-MHR derives from the coupling of a small, passively safe, modular reactor directly with a compact power conversion module. It uses the Brayton cycle to produce electricity directly with the primary helium coolant driving the turbine-generator. Thus, it shows promise for a quantum reduction in power generation costs by increasing plant efficiency to a remarkable 48% This paper highlights the advantages of the fact that the design is based on proven technology, and offers a clean, economic and safe energy for electricity and high temperature process heat. 2 refs., 4 figs

1994-04-01

274

Candida glabrata endophthalmitis following penetrating keratoplasty in a patient with negative donor rim culture  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Candida glabrata endophthalmitis following keratoplasty is rare and almost always associated with positive donor rim culture. Case presentation A 63-year-old patient, diagnosed Fuch's endothelial dystrophy in both eyes underwent a penetrating keratoplasty in his right eye. He had multiple underlying medical problems, which included diabetes mellitus, hypertension, hypoadrenalism on oral dexamethasone and fatty liver secondary to hypertrigliseridemia. He developed multiple suture abscesses, corneal haziness, retrocorneal white plaques and a level of hypopyon two weeks after an uneventful penetrating keratoplasty in his right eye. Cultures of the donor button and the transport media culture were negative. Candida glabrata was isolated successfully from the aqueous and vitreous taps. He was treated with a combination of topical, intracameral, intravitreal and intravenous Amphotericin B. His final visual acuity remained poor due to the haziness of the corneal button. Conclusion Candida glabrata endophthalmitis following penetrating keratoplasty can occur in negative donor rim and transport media cultures. The growth of the organism is facilitated by the patient's immunocompromised status. Awareness by the ophthalmologists and appropriate choice of antibiotics are mandatory in this challenging condition.

Ibrahim Mohtar

2010-06-01

275

Modeling Eclipses in the Classical Nova V Persei: The Role of the Accretion Disk Rim  

CERN Document Server

Multicolor (BVRI) light curves of the eclipsing classical nova V Per are presented, and a total of twelve new eclipse timings have been measured for the system. When combined with previous eclipse timings from the literature, these timings yield a revised ephemeris for the times of mid-eclipse given by HJD = 2,447,442.8620(1) + 0.107123474(3) E. The eclipse profiles have been analyzed with a parameter-fitting model that assumes four sources of luminosity: a white dwarf primary star, a main-sequence secondary star, a flared accretion disk with a rim, and a bright spot at the intersection of the mass transfer stream and the disk periphery. A matrix of model solutions have been computed, covering an extensive range of plausible parameter values. The solution matrix was then explored to determine the optimum values for the fitting parameters and their associated errors. For models that treat the accretion disk as a flat structure without a rim, optimum fits require that the disk have a flat temperature profile. A...

Shafter, A W

2006-01-01

276

Pyogenic osteomyelitis of long bone: MR findings  

International Nuclear Information System (INIS)

To evaluate the usefulness of MR in the osteomyelitis, we reviewed MR examinations of 14 patients with pyogenic osteomyelitis of the long bone. All 14 patients were confirmed to have osteomyelitis either surgically (13/14) or by aspiration (1/14). MRI was performed with 0.5 T (n=8) or 2.0 T (n=6) SE technique, and Gd-DTPA enhanced T1WI was obtained in 10 examinations. Anatomic location of lesions were femur (8/14), tibia (5/14) , and fibula (1/14). The marrow cavity and soft tissue were involved in 13/14, 12/14 respectively. The signals of both intraosseous and extraosseous infected area were iso to low signal intensity to muscles on T1WI and high signal intensity on PDWI and T2WI. Rim or diffuse enhancement of the marrow cavity and soft tissue were seen in all (10/10) case. Sequestra, periosteal reaction, and cortical defect were found in 12/14, 10/14, 9/14. MR provided more accurate and detailed anatomic information including extent of disease and possible activity than bone scintigraphy, CT, or conventional radiography. We conclude that MR might be the choice of modality in the diagnosis of osteomyelitis of the long bone

1994-10-01

277

Subperiosteal ganglion associated with Paget's disease of bone  

International Nuclear Information System (INIS)

Tumoral lesions related to Paget's disease may be classified as malignant, benign or pseudotumoral. While sarcomatous degeneration is the most feared complication, awareness of benign and pseudotumoral lesions is essential for assisting in accurate histological interpretation of the biopsy sample, which may avoid unnecessary repeat biopsies. We present the first case of a juxta-articular subperiosteal ganglion associated with Paget's disease, with classic imaging characteristics, especially on CT examination. The well-defined soft tissue mass at the medial aspect of the obturator rim, adjacent to a small fracture in pagetic quadrilateral plate, showed an ossified rim and internal gas lucencies, these being the hallmarks of a juxta-articular subperiosteal ganglion. On MRI, the lesion was of intermediate signal intensity on T1-weighted sequences, increased signal intensity on T2-weighted sequences, with rim enhancement after gadolinium contrast injection and preservation of fatty marrow signal of the underlying pagetic bone. Identification of the entity avoided an unnecessary biopsy or surgical intervention. (orig.)

2005-07-01

278

A ceramic/slag interface as an analog for accretion of hot refractory objects and rim formation  

Science.gov (United States)

Refractory inclusions or Ca-Al-rich inclusions (CAI's) from carbonaceous chondrites span a wide range of bulk compositions that cannot be explained either by segregation from a gas of solar composition at different points in the condensation sequence or by fractional crystallization from a parent liquid. CAI's are commonly rimmed by Wark-Lovering (W-L) rims, a series of nearly monomineralic layers that have been a source of controversy since the variety of rim sequences occurring on different types of CAI's from Allende were described. The origin of these distinctive features has not yet been resolved, with proponents of accretion, condensation, flash heating, ablation, evaporation, etc. Rims have generated considerable interest because they potentially contain clues to conditions experienced by CAI's after the formation of the inclusion and prior to incorporation into the parent body. Ceramic bricks in contact with hot steel slag may produce reaction products in rimlike fashion similar to those found in CAI's. The similarity between the mineralogy of blast furnace slags and CAI's has long been recognized, with both containing unusual phases not found in terrestrial materials. We provide here a comparison between a ceramic brick/slag multiple-layered interface and a multiple-layered interface between a melilite-perovskite object and a melilite-spinel object in the Allende inclusion USNM 4691-1. These results have implications in interpreting the origin of rims and the textures and compositions of CAI's.

Paque, J. M.; Bunch, T. E.

1994-01-01

279

Atypical sino-orbital inflammatory myofibroblastic tumor with bone and cerebral invasion extending to the orbit.  

Science.gov (United States)

Purpose: To report the case of an atypical sino-orbital inflammatory myofibroblastic tumor.Methods: Case report.Results: A 71-year-old man presented slowly progressive painless diplopia followed by unilateral proptosis of the left eye with slight edema of the upper eyelid. Visual acuity was 0.4 with a relative afferent pupillary defect (RAPD). Abduction and depression of the left eye were limited. Imaging showed a left sino-orbital tumor with mass effect on the medial rectus muscle resulting in proptosis. The lesion showed intracranial extension through the superior orbital fissure with bone erosion and sclerotic bone reaction. Endoscopic ethmoidal, maxillary, and orbital biopsies revealed an inflammatory myofibroblastic tumor. Full blood count showed an eosinophilia while antineutrophil cytoplasmic antibodies and C-reactive protein were negative. To date, 7 cases of orbital myofibroblastic tumor have been described, though none of the prior studies have described bone invasion.Conclusions: This erosive sino-orbital inflammatory myofibroblastic tumor is a novel finding mimicking a malignant tumor. PMID:24338574

Lauwers, Noémie; De Groot, Veva; Kenis, Christoph; Dhubhghaill, Sorcha Ní; Claes, Jos; De Keizer, Robert J W

2014-06-23

280

Rim em ferradura com cistos e ureter único: relato de caso Horseshoe kidney with cysts and a single ureter: a case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

O rim em ferradura é a mais comum de todas as anomalias de fusão, ocorrendo em aproximadamente 0,25% da população geral. O rim em ferradura com ureter único é uma rara anomalia. Um paciente do sexo masculino de 60 anos foi admitido para investigação rotineira de triagem. Sua história familiar era negativa para doenças renais e o exame físico foi considerado normal. A tomografia computadorizada revelou um rim em ferradura atípico com cistos e a reconstrução tridimensional na tomo...

2010-01-01

 
 
 
 
281

Highly cross-linked vs conventional polyethylene: no differences in rim notching from micromotion on retrieved acetabular liners.  

Science.gov (United States)

Previous literature suggested highly cross-linked acetabular liners demonstrated notching patterns that may be a point of crack origin and rim failure. We examined (1) whether notching patterns and rim cracks existed and demonstrated similar morphological properties in retrieved highly cross-linked and non-cross-linked liners and (2) whether the dimensions of these notches correlated with their duration of implantation. We retrieved a series of 14 identical liners out to an average of 2.03 years. Liners were microscopically examined and then scanned using microcomputed tomography. All liners demonstrated identical notching patterns. Microcomputed tomographic scans demonstrated no signs of crack initiation or rim failure but were able to accurately quantify the notch dimensions. The notching patterns were likely caused by liner-cup micromotion and are better characterized as creep deformation because they did not progress markedly over longer durations of implantation. PMID:22608684

Paterson, Nicholas R; Teeter, Matthew G; Macdonald, Steven J; McCalden, Richard W; Howard, James L; Naudie, Douglas D R

2012-10-01

282

Crack propagation studies to determine benign or catastrophic failure modes for aerospace thin-rim gears. Ph.D. Thesis  

Energy Technology Data Exchange (ETDEWEB)

Analytical and experimental studies were performed to investigate the effect of rim thickness on gear tooth crack propagation. The goal was to determine whether cracks grew through gear teeth (benign failure mode) or through gear rims (catastrophic failure mode) for various rim thicknesses. Gear tooth crack propagation was simulated using a finite element based computer program. Principles of linear elastic fracture mechanics were used. Quarter-point, triangular elements were used at the crack tip to represent the stress singularity. Crack tip stress intensity factors were estimated and used to determine crack propagation direction and fatigue crack growth rate. The computer program used had an automated crack propagation option in which cracks were grown numerically using an automated re-meshing scheme. In addition, experimental studies were performed in the NASA Lewis Spur Gear Fatigue Rig. Gears with various backup ratios were tested to validate crack path predictions. Also, specialized crack propagation gages were installed on the test gears to measure gear tooth crack growth rate. From both predictions and tests, gears with backup ratios (film thickness divided by tooth height) of 3.3 and 1.0 produced tooth fractures while a backup ratio of 0.3 produced rim fractures. For a backup ratio of 0.5, the experiments produced rim fractures and the predictions produced both rim and tooth fractures, depending on the initial crack conditions. Good correlation between the predicted number of crack propagation cycles and measured number of cycles was achieved using both the Paris fatigue crack growth method and the Collipfiest crack growth equation when fatigue crack closure was considered.

Lewicki, D.G.

1996-05-01

283

Modelo de tumor experimental em rim de ratos Experimental tumor model in rats kidney  

Directory of Open Access Journals (Sweden)

Full Text Available O carcinossarcoma 256 de Walker tem despertado o interesse de muitos pesquisadores como modelo experimental para estudo da biologia tumoral. OBJETIVO: estabelecer um modelo de tumor renal que possa ser usado para estudar in vivo e in vitro, as alterações impostas pelas neoplasias. MÉTODOS: utilizados vinte ratos Wistar, machos, adultos, pesando entre 250-300 g, oriundos do Laboratório de Cirurgia Experimental da Universidade Federal do Ceará. Sob anestesia inalatória procedia-se uma pequena incisão supraumbilical, e com manobra delicada fazia-se a exposição do rim direito. Neste órgão eram inoculadas 3x10(5 células tumorais viáveis. Os animais então eram mantidos em gaiolas individuais com as mesmas condições ambientais e com água e dieta ad libitum. RESULTADOS: o Carcinossarcoma 256 de Walker, implantado no parênquima do rim direito de ratos Wistar apresentou índice de pega de 100%, e crescimento rápido, invadiu por contiguidade as estruturas vizinhas, porém sem apresentar metástases, no entanto, levando os animais a óbito no curso médio de 14 dias. CONCLUSÃO: o modelo de implante de tumor de Walker no parênquima do rim direito de ratos Wistar é eficiente, tem reprodutibilidade, apresentando um índice de pega de 100%, e permitindo seu uso em linhas de pesquisa.Walker carcinossarcoma 256 has a great interest as experimental model for studies on tumoral biology. OBJECTIVE: develop a kidney tumor model to be used in the evaluation of the biological behavior of neoplasms in vitro and in vivo environments. METHODS: twenty adult male Wistar rats weighting between 250-300 g were obtained from the Federal University of the Ceará Experimental Surgery Laboratory. Upon ether anesthesia, the right kidney of each animal was accessed through a supraumbelical incision and inoculated with a solution containing 3 x 10(5 tumor cells (Walker 256 carcinossarcoma tumor cells. Following anesthetic recovery the rats were returned to their cages, housed individually and allowed to eat and drink ad libitum. RESULTS: the post-operative average survival was 14 days. Tumor growth was encountered in all animals. The rats exhibited destruction of the kidney, invasion of the adjacent structures, but absence of metastasis. CONCLUSION: the kidney Walker tumor model proved to be an excellent tool for experimental studies on tumor behavior, due to its rapid growth and its easy reproduction.

Lúcio Flávio Gonzaga Silva

2002-02-01

284

Modelo de tumor experimental em rim de ratos / Experimental tumor model in rats kidney  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O carcinossarcoma 256 de Walker tem despertado o interesse de muitos pesquisadores como modelo experimental para estudo da biologia tumoral. OBJETIVO: estabelecer um modelo de tumor renal que possa ser usado para estudar in vivo e in vitro, as alterações impostas pelas neoplasias. MÉTODOS: utilizado [...] s vinte ratos Wistar, machos, adultos, pesando entre 250-300 g, oriundos do Laboratório de Cirurgia Experimental da Universidade Federal do Ceará. Sob anestesia inalatória procedia-se uma pequena incisão supraumbilical, e com manobra delicada fazia-se a exposição do rim direito. Neste órgão eram inoculadas 3x10(5) células tumorais viáveis. Os animais então eram mantidos em gaiolas individuais com as mesmas condições ambientais e com água e dieta ad libitum. RESULTADOS: o Carcinossarcoma 256 de Walker, implantado no parênquima do rim direito de ratos Wistar apresentou índice de pega de 100%, e crescimento rápido, invadiu por contiguidade as estruturas vizinhas, porém sem apresentar metástases, no entanto, levando os animais a óbito no curso médio de 14 dias. CONCLUSÃO: o modelo de implante de tumor de Walker no parênquima do rim direito de ratos Wistar é eficiente, tem reprodutibilidade, apresentando um índice de pega de 100%, e permitindo seu uso em linhas de pesquisa. Abstract in english Walker carcinossarcoma 256 has a great interest as experimental model for studies on tumoral biology. OBJECTIVE: develop a kidney tumor model to be used in the evaluation of the biological behavior of neoplasms in vitro and in vivo environments. METHODS: twenty adult male Wistar rats weighting betwe [...] en 250-300 g were obtained from the Federal University of the Ceará Experimental Surgery Laboratory. Upon ether anesthesia, the right kidney of each animal was accessed through a supraumbelical incision and inoculated with a solution containing 3 x 10(5) tumor cells (Walker 256 carcinossarcoma tumor cells). Following anesthetic recovery the rats were returned to their cages, housed individually and allowed to eat and drink ad libitum. RESULTS: the post-operative average survival was 14 days. Tumor growth was encountered in all animals. The rats exhibited destruction of the kidney, invasion of the adjacent structures, but absence of metastasis. CONCLUSION: the kidney Walker tumor model proved to be an excellent tool for experimental studies on tumor behavior, due to its rapid growth and its easy reproduction.

Lúcio Flávio Gonzaga, Silva; Felipe dos Santos Dias, Soares; José Nilson Nunes, Anselmo; Daniel Mota Moura, Fé; João Luiz Barbosa Gurgel, Cavalcante; Manoel Odorico de, Moraes; Paulo Roberto Leitão de, Vasconcelos.

285

Triggered Star Formation and Young Stellar Population in Bright-rimmed Cloud SFO 38  

Science.gov (United States)

We have investigated the young stellar population in and around SFO 38, one of the massive globules located in the northern part of the Galactic H II region IC 1396, using the Spitzer IRAC and MIPS observations (3.6-24 ?m), and followed up with ground-based optical photometric and spectroscopic observations. Based on the IRAC and MIPS colors and H? emission, we identify ~45 young stellar objects (Classes 0/I/II) and 13 probable pre-main-sequence candidates. We derive the spectral types (mostly K- and M-type stars), effective temperatures, and individual extinction of the relatively bright and optically visible Class II objects. Most of the Class II objects show variable H? emission as well as optical and near-infrared photometric variability, which confirm their "youth." Based on optical photometry and theoretical isochrones, we estimate the spread in stellar ages to be between 1 and 8 Myr with a median age of 3 Myr and a mass distribution of 0.3-2.2 M sun with a median value around 0.5 M sun. Using the width of the H? emission line measured at 10% peak intensity, we derive the mass accretion rates of individual objects to be between 10-10 and 10-8 M sun yr-1. From the continuum-subtracted H? line image, we find that the H? emission of the globule is not spatially symmetric with respect to the O-type ionizing star HD 206267, and the interstellar extinction toward the globule is also anomalous. We clearly detect an enhanced concentration of YSOs closer to the southern rim of SFO 38 and identify an evolutionary sequence of YSOs from the rim to the dense core of the cloud, with most of the Class II objects located at the bright rim. The YSOs appear to be aligned along two different directions toward the O6.5V type star HD 206267 and the B0V type star HD 206773. This is consistent with the Radiation Driven Implosion (RDI) model for triggered star formation. Further, the apparent speed of sequential star formation is consistent with the speed of propagation of shocks in dense globules as derived from numerical simulations of RDI.

Choudhury, Rumpa; Mookerjea, Bhaswati; Bhatt, H. C.

2010-07-01

286

TRIGGERED STAR FORMATION AND YOUNG STELLAR POPULATION IN BRIGHT-RIMMED CLOUD SFO 38  

International Nuclear Information System (INIS)

We have investigated the young stellar population in and around SFO 38, one of the massive globules located in the northern part of the Galactic H II region IC 1396, using the Spitzer IRAC and MIPS observations (3.6-24 ?m), and followed up with ground-based optical photometric and spectroscopic observations. Based on the IRAC and MIPS colors and H? emission, we identify ?45 young stellar objects (Classes 0/I/II) and 13 probable pre-main-sequence candidates. We derive the spectral types (mostly K- and M-type stars), effective temperatures, and individual extinction of the relatively bright and optically visible Class II objects. Most of the Class II objects show variable H? emission as well as optical and near-infrared photometric variability, which confirm their 'youth'. Based on optical photometry and theoretical isochrones, we estimate the spread in stellar ages to be between 1 and 8 Myr with a median age of 3 Myr and a mass distribution of 0.3-2.2 Msun with a median value around 0.5 Msun. Using the width of the H? emission line measured at 10% peak intensity, we derive the mass accretion rates of individual objects to be between 10-10 and 10-8 Msun yr-1. From the continuum-subtracted H? line image, we find that the H? emission of the globule is not spatially symmetric with respect to the O-type ionizing star HD 206267, and the interstellar extinction toward the globule is also anomalous. We clearly detect an enhanced concentration of YSOs closer to the southern rim of SFO 38 and identify an evolutionary sequence of YSOs from the rim to the dense core of the cloud, with most of the Class II objects located at the bright rim. The YSOs appear to be aligned along two different directions toward the O6.5V type star HD 206267 and the B0V type star HD 206773. This is consistent with the Radiation Driven Implosion (RDI) model for triggered star formation. Further, the apparent speed of sequential star formation is consistent with the speed of propagation of shocks in dense globules as derived from numerical simulations of RDI.

2010-07-10

287

New prospects for plutonium speciation - CE-RIMS and CE-DAD-ICP-MS  

Energy Technology Data Exchange (ETDEWEB)

Full text of publication follows: In the last years, capillary electrophoresis (CE)-ICP-MS has been applied successfully for the speciation of plutonium and neptunium [1] in aqueous solutions, especially in groundwater samples. To achieve lower detection limits and to determine complexing agents, two detection methods, namely RIMS and DAD, coupled with the separation technique CE are under investigation. A detection limit of 20 ppb was found for plutonium with an ICP-QMS, whereas with the coupling with a sector field ICP-HRMS 100 ppt could be detected. The off-line coupling of CE to the very sensitive resonance ionisation mass spectrometry (RIMS) with an absolute detection limit of 106 atoms gives new options. For this, a sample is injected into the CE-capillary and the separated oxidation states of Pu(III), Pu(VI/V) and Pu(IV) are collected in different fractions from which filaments are prepared for the RIMS measurements [2]. The migration times of the different Pu species have been previously calibrated by means of the CE-ICP-MS. The second innovation is the combination of a diode array detector (DAD) with the CE-ICP-MS. In addition to the information on the metal ions detected by the ICP-MS, the DAD can detect complexing agents like humic acid and also the electro-osmotic flow (EOF) by a suitable marker like acetone. This is necessary for internal standardisation of the migration times of the species in the capillary. By applying both detection methods, it is possible to determine in an anionic run free humic acid, humate complexed metal ions, and other (humate free) anionic metal species. In a cationic run, the free metal ions can be detected. This will enable the determination of complex formation constants. Related results will be presented at the conference. [1] B. Kuczewski et al.: Analytical Chemistry, 2003, 75, 6769-6774. [2] N. Trautmann et al.: Analytical and Bioanalytical Chemistry, 2004, 378, 348-355. (authors)

Kuczewski, B.; Banik, N.L.; Buerger, S.; Buda, R.; Kratz, J.V.; Trautmann, N. [Universitaet Mainz, Institut fuer Kernchemie, D-55099 Mainz (Germany)

2005-07-01

288

The bone scintigraphy  

International Nuclear Information System (INIS)

In this article, the author presents the principles of a bone scintigraphy, the radiopharmaceuticals that are used, and explains its advantages in diagnosis of bone diseases as bone metastases, Paget's diseases, osteoporosis, osteomyelitis, osteoma, etc

1993-01-01

289

Calcium and bones  

Science.gov (United States)

... grow properly. Bone density refers to how much calcium and other types of minerals are present in a section of your bone. Bone density is highest between ages 25 - 35. It goes down as you get older. This ...

290

Functional Coupling of Rab3-interacting Molecule 1 (RIM1) and L-type Ca2+ Channels in Insulin Release*  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Insulin release by pancreatic ?-cells is regulated by diverse intracellular signals, including changes in Ca2+ concentration resulting from Ca2+ entry through voltage-gated (CaV) channels. It has been reported that the Rab3 effector RIM1 acts as a functional link between neuronal CaV channels and the machinery for exocytosis. Here, we investigated whether RIM1 regulates recombinant and native L-type CaV channels (that play a key role in hormone secretion) and whether this regulation affects ...

2011-01-01

291

The CT flare response of metastatic bone disease in prostate cancer  

International Nuclear Information System (INIS)

Background New or worsening bone lesions in patients responding to treatment, known as the flare phenomenon is well described on 99mTc-MDP bone scintigraphy, but to our knowledge has not previously been described on CT. The appearance of new or worsening bone sclerosis on CT in patients with prostate cancer may therefore be erroneously classified as disease progression. Purpose To assess the incidence of osteoblastic healing flare response at 3-month CT assessment in patients with castrate-resistant prostate cancer and to identify associated features that enable differentiation from progressive metastatic bone disease at 3 months. Material and Methods CT scans of 67 patients with castrate-resistant prostate cancer undergoing treatment were reviewed by a radiologist blinded to clinical outcome. Changes in number, size, and density of metastatic bone lesions were documented and Response Evaluation Criteria in Solid Tumours (RECIST) in soft tissue lesions, alkaline phosphatase, prostate specific antigen, and 99mTc-MDP bone scans were used for correlation. Results Of the 39 patients who had 3- and 6-month follow-up, eight patients (21%) demonstrated an increase in number, size, or density of sclerotic lesions on the 3-month CT scan despite improvement in PSA and soft tissue lesions. Three out of eight patients (8%) maintained partial response/remained stable at follow-up and were defined as showing a flare response: in this group bone metastases evident on CT showed a qualitative and quantitative increase in density and no lesions faded at 3 months. In contrast, in all patients who progressed at 3 months by PSA/RECIST criteria (n = 8) bone lesions showed a mixed pattern with some lesions increasing and others decreasing in density. Conclusion The incidence of flare response of metastatic bone disease evident at 3-month post-treatment CT in patients with prostate cancer undergoing systemic treatment is 8%. In patients with falling PSA and stable/responding soft tissue disease at 3 months an increase in bone sclerosis in the absence of fading bone metastases can be interpreted as flare and is likely to represent a response

2011-06-01

292

The CT flare response of metastatic bone disease in prostate cancer  

Energy Technology Data Exchange (ETDEWEB)

Background New or worsening bone lesions in patients responding to treatment, known as the flare phenomenon is well described on 99mTc-MDP bone scintigraphy, but to our knowledge has not previously been described on CT. The appearance of new or worsening bone sclerosis on CT in patients with prostate cancer may therefore be erroneously classified as disease progression. Purpose To assess the incidence of osteoblastic healing flare response at 3-month CT assessment in patients with castrate-resistant prostate cancer and to identify associated features that enable differentiation from progressive metastatic bone disease at 3 months. Material and Methods CT scans of 67 patients with castrate-resistant prostate cancer undergoing treatment were reviewed by a radiologist blinded to clinical outcome. Changes in number, size, and density of metastatic bone lesions were documented and Response Evaluation Criteria in Solid Tumours (RECIST) in soft tissue lesions, alkaline phosphatase, prostate specific antigen, and 99mTc-MDP bone scans were used for correlation. Results Of the 39 patients who had 3- and 6-month follow-up, eight patients (21%) demonstrated an increase in number, size, or density of sclerotic lesions on the 3-month CT scan despite improvement in PSA and soft tissue lesions. Three out of eight patients (8%) maintained partial response/remained stable at follow-up and were defined as showing a flare response: in this group bone metastases evident on CT showed a qualitative and quantitative increase in density and no lesions faded at 3 months. In contrast, in all patients who progressed at 3 months by PSA/RECIST criteria (n = 8) bone lesions showed a mixed pattern with some lesions increasing and others decreasing in density. Conclusion The incidence of flare response of metastatic bone disease evident at 3-month post-treatment CT in patients with prostate cancer undergoing systemic treatment is 8%. In patients with falling PSA and stable/responding soft tissue disease at 3 months an increase in bone sclerosis in the absence of fading bone metastases can be interpreted as flare and is likely to represent a response

Messiou, Christina; deSouza, Nandita M. (Cancer Research UK Clinical Magnetic Resonance Research Group, Inst. of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey (United Kingdom)), email: Christina.Messiou@icr.ac.uk; Cook, Gary (Dept. of Nuclear Medicine, Royal Marsden NHS Foundation Trust, Surrey (United Kingdom)); Reid, Alison H.M.; Attard, Gerhardt; Dearnaley, David; deBono, Johann S. (Inst. of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey (United Kingdom))

2011-06-15

293

Controlled mode tuning in 1-D 'RIM' plasmonic crystal trench cavities probed with coupled optical emitters.  

Science.gov (United States)

We present a design of plasmonic cavities that consists of two sets of 1-D plasmonic crystal reflectors on a plasmonic trench waveguide. A 'reverse image mold' (RIM) technique was developed to pattern high-resolution silver trenches and to embed emitters at the cavity field maximum, and FDTD simulations were performed to analyze the frequency response of the fabricated devices. Distinct cavity modes were observed from the photoluminescence spectra of the organic dye embedded within these cavities. The cavity geometry facilitates tuning of the modes through a change in cavity dimensions. Both the design and the fabrication technique presented could be extended to making trench waveguide-based plasmonic devices and circuits. PMID:24514557

Liu, Tsung-li; Russell, Kasey J; Cui, Shanying; Hu, Evelyn L

2013-12-01

294

An Investigation on the Morphological Evolution of Bright-Rimmed Clouds  

CERN Document Server

A new Radiative Driven Implosion (RDI) model based on Smoothed Particle Hydrodynamics (SPH) technique is developed and applied to investigate the morphological evolutions of molecular clouds under the effect of ionising radiation. This model self-consistently includes the self-gravity of the cloud in the hydrodynamical evolution, the UV radiation component in the radiation transfer equations, the relevant heating and cooling mechanisms in the energy evolution and a comprehensive chemical network. The simulation results reveal that under the effect of ionising radiation, a molecular cloud may evolve through different evolutionary sequences. Dependent on its initial gravitational state, the evolution of a molecular cloud does not necessarily follow a complete morphological evolution sequence from type A to B to C, as described by previous RDI models. When confronted with observations, the simulation results provide satisfactory physical explanations for a series of puzzles derived from Bright-Rimmed Clouds (BRC...

Miao, J; Thompson, M A; Nelson, R P

2008-01-01

295

Physical model development for prediction of rim-layer formation in UO2 fuel  

International Nuclear Information System (INIS)

Results of point defects and gas atom behaviour modelling in UO2 fuel are presented for the temperature conditions for rim-layer formation. The spatial profiles for vacancy and interstitial atom concentrations in the vicinity of the grain boundaries and near edge dislocations are different. In the initial stage of irradiation, the peak of vacancy concentration is near the grain boundary. During long irradiation the vacancy peak vanishes and a peak of interstitial atoms arises. Vacancy concentration can have a maximum close to the dislocation core. Analysis of gas atom mobility at low temperature irradiation indicates a reducing dependence of Xe effective diffusion coefficient on vacancy concentration. The developed physical models enable the proposal of explanations for experimental facts: grain diameter effect on the threshold for the beginning of fuel restructuring and priority formation of large bubbles on dislocation intersections. (author)

2005-07-01

296

Late Cainozoic drainage evolution in the Zambezi basin: Geomorphological evidence from the Kalahari rim  

Science.gov (United States)

The development of the Zambezi drainage system is discussed within the framework of the post-Gondwana tectonic evolution of southern Africa. An internal drainage system, including teh proto-Upper Zambezi, has been progressively captured during the late Cainozoic by a more agressive coastwise system. Supporting geomorphic evidence is presented from the eastern Kalahari rim. Drainage alignments and gradients, and terrace sequences are discussed. Lacustrine features found on the present watershed between the Middle Zambezi and internal systems are described and explained as remnants of the former proto-Upper Zambezi tributary system. Their interaction with linear dune activity is also examined. Despite the problems of dating the drainage changes described, it is concluded that their elucidation is important in understanding sedimentation and landform development in the eastern part of the Kalahari basin.

Thomas, David S. G.; Shaw, Paul A.

297

Growth and instability of the liquid rim in the crown splash regime  

CERN Document Server

We study the formation, growth, and disintegration of jets following impact of a drop on a thin film of the same liquid for We < 1000 and Re < 2000 using a combination of numerical simulations and linear stability theory (Agbaglah et al. 2013). Our simulations faithfully capture this phenomena and are in good agreement with experimental profiles obtained from high-speed X-ray imaging.We obtain scaling relations from our simulations and use these as inputs to our stability analysis. The resulting prediction for the most unstable wavelength are in excellent agreement with experimental data. Our calculations show that the dominant destabilizing mechanism is a competition between capillarity and inertia but that deceleration of the rim provides an additional boost to growth. We also predict over the entire parameter range of our study the number and timescale for formation of secondary droplets formed during a splash, based on the assumption that the most unstable mode sets the droplet number.

Agbaglah, G

2014-01-01

298

Outpatient treatment of microscopic and rim hyphemas in children with tranexamic acid.  

Science.gov (United States)

Twenty-one patients aged 4 to 15 years with microscopic or rim hyphemas were treated as out-patients with systemic tranexamic acid therapy. The protocol included limited activity at home, topical steroid therapy, no dilating drops, patching for comfort or surface abrasions only, and follow-up every 24 to 48 hours. With this regimen no patient had a secondary hemorrhage. The incidence of associated injuries was surprisingly high, including four patients with angle recession, two with choroidal ruptures and four with commotio retinae, two of whom manifested retinal holes, requiring cryotherapy. We conclude that tranexamic acid therapy decreases the risk of secondary hemorrhage in ambulatory patients with hyphema, but careful assessment and follow-up are necessary to rule out associated ocular injury. PMID:8313219

Clarke, W N; Noël, L P

1993-12-01

299

The Difference in Translaminar Pressure Gradient and Neuroretinal Rim Area in Glaucoma and Healthy Subjects  

Science.gov (United States)

Purpose. To assess differences in translaminar pressure gradient (TPG) and neuroretinal rim area (NRA) in patients with normal tension glaucoma (NTG), high tension glaucoma (HTG), and healthy controls. Methods. 27 patients with NTG, HTG, and healthy controls were included in the prospective pilot study (each group consisted of 9 patients). Intraocular pressure (IOP), intracranial pressure (ICP), and confocal laser scanning tomography were assessed. TPG was calculated as the difference of IOP minus ICP. ICP was measured using noninvasive two-depth transcranial Doppler device. The level of significance P 0.05). The difference between TPG for healthy (5.4(7.7)?mmHg) and glaucomatous eyes (NTG 6.3(3.1)?mmHg, HTG 15.7(7.7)?mmHg) was statistically significant (P glaucoma patients. Reduction of NRA was related to higher TPG in NTG patients. Further prospective studies are warranted to investigate the involvement of TPG in glaucoma management.

Siaudvytyte, Lina; Ragauskas, Arminas; Meiliuniene, Indre; Harris, Alon

2014-01-01

300

X-RAY PROPER MOTIONS AND SHOCK SPEEDS ALONG THE NORTHWEST RIM OF SN 1006  

International Nuclear Information System (INIS)

We report the results of an X-ray proper-motion measurement for the NW rim of SN 1006, carried out by comparing Chandra observations from 2001 to 2012. The NW limb has predominantly thermal X-ray emission, and it is the only location in SN 1006 with significant optical emission: a thin, Balmer-dominated filament. For most of the NW rim, the proper motion is ?0.''30 yr–1, essentially the same as has been measured from the H? filament. Isolated regions of the NW limb are dominated by nonthermal emission, and here the proper motion is much higher, 0.''49 yr–1, close to the value measured in X-rays along the much brighter NE limb, where the X-rays are overwhelmingly nonthermal. At the 2.2 kpc distance to SN 1006, the proper motions imply shock velocities of ?3000 km s–1 and ?5000 km s–1 in the thermal and nonthermal regions, respectively. A lower velocity behind the H? filament is consistent with the picture that SN 1006 is encountering denser gas in the NW, as is also suggested by its overall morphology. In the thermally dominated portion of the X-ray shell, we also see an offset in the radial profiles at different energies; the 0.5-0.6 keV peak dominated by O VII is closer to the shock front than that of the 0.8-3 keV emission—due to the longer times for heavier elements to reach ionization states where they produce strong X-ray emission.

2013-02-01

 
 
 
 
301

Degree of coordination between breathing and rhythmic arm movements during hand rim wheelchair propulsion.  

Science.gov (United States)

This study aimed (i) to quantify the spontaneous coordination between breathing and hand rim wheelchair propulsion, (ii) to manipulate arm movement frequency and assess its effects on spontaneous coordination, and (iii) to investigate the hypothesis that entrainment of breathing improves economy of locomotion and leads to a lower rate of perceived exertion (RPE) compared with spontaneous breathing. Nine male, able-bodied participants completed four bouts of 6 min submaximal steady state exercise at 60 % of maximal propulsion velocity on a wheelchair ergometer, with spontaneous breathing and arm frequencies (Fspont), with 20 % higher and lower arm frequencies (F +20 and F -20, respectively) compared to Fspont accompanied with spontaneous breathing frequency, and by synchronising expiration phase with pushing time and inspiration phase with upper limb recovery time (C). Oxygen uptake and propulsion frequency were continuously recorded. The degree of coordination was expressed as a percentage of inspiration starting in the same phase of the wheelchair propulsion cycle (i.e. pushing and recovery times). No difference in degree of coordination was observed between Fspont, F -20 and F +20 conditions (49.2 +/- 12.1 %, 49.1 +/- 29.0 % and 48.2 +/- 29.4 %, respectively). Oxygen uptake increased significantly during C condition while RPE was significantly lower for C and F -20 (p < 0.05) compared to F +20 conditions. Contrary to what we expected, entrainment of breathing using a monofrequency ratio (C) induced a higher energy cost probably due to the mechanical properties of the wheelchair propulsion activity itself. In conclusion, this study showed that the same locomotor-respiratory coupling occurred during hand rim wheelchair propulsion regardless of the arm movement frequency, and that entrainment of breathing did not improve economy of locomotion. PMID:16388445

Fabre, N; Perrey, S; Arbez, L; Ruiz, J; Tordi, N; Rouillon, J D

2006-01-01

302

Distal myopathy with rimmed vacuoles: Report on clinical characteristics in 23 cases  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Distal myopathy with rimmed vacuoles (DMRV is an autosomal recessive (AR myopathy characterized clinically by the preferential involvement of the tibialis anterior and has been reported predominantly in the Japanese population. Materials and Methods: A case series of DMRV patients seen over a period of 3 years at a tertiary national referral center for neurological disorders in south India. Results: We describe the clinical characteristics, muscle magnetic resonance imaging (MRI findings and classical histopathological feature in 23 patients. There were 12 men and 11 women. Mean age of onset was 27.04 ± 6.35 years (10-39 years. Onset was in the second or third decade in a majority. Mean age at presentation was 33.95 ± 6.35 years (25-48 years. Mean duration of illness was 6.74 ± 4.8 years (1-18 years. Consanguinity was reported in eight (34.8% patients. The predominant and initial manifestation was bilateral foot drop in all patients. Muscle MRI demonstrated classical involvement of the anterior compartment muscles of the lower legs and the posterior compartment muscles of the thighs and the quadriceps was normal in all. Muscle histopathology showed numerous fibers containing rimmed vacuoles. Necrotic fibers or phagocytosis or regenerating fibers were rarely noted or were absent. Conclusions: DMRV is a rare AR myopathy. The disorder presents as progressive foot drop and hence has many differential diagnoses. It is easily mistaken as neuropathy of hereditary nature and hence it is extremely important to recognize the preferential muscle involvement and characterize the phenotype. This is the first report from India with patients having characteristic phenotype of Nonaka?s/AR hereditary inclusion body myopathy with quadriceps sparing, and all were confirmed by histopathology.

Nalini A

2010-01-01

303

X-RAY PROPER MOTIONS AND SHOCK SPEEDS ALONG THE NORTHWEST RIM OF SN 1006  

Energy Technology Data Exchange (ETDEWEB)

We report the results of an X-ray proper-motion measurement for the NW rim of SN 1006, carried out by comparing Chandra observations from 2001 to 2012. The NW limb has predominantly thermal X-ray emission, and it is the only location in SN 1006 with significant optical emission: a thin, Balmer-dominated filament. For most of the NW rim, the proper motion is Almost-Equal-To 0.''30 yr{sup -1}, essentially the same as has been measured from the H{alpha} filament. Isolated regions of the NW limb are dominated by nonthermal emission, and here the proper motion is much higher, 0.''49 yr{sup -1}, close to the value measured in X-rays along the much brighter NE limb, where the X-rays are overwhelmingly nonthermal. At the 2.2 kpc distance to SN 1006, the proper motions imply shock velocities of {approx}3000 km s{sup -1} and {approx}5000 km s{sup -1} in the thermal and nonthermal regions, respectively. A lower velocity behind the H{alpha} filament is consistent with the picture that SN 1006 is encountering denser gas in the NW, as is also suggested by its overall morphology. In the thermally dominated portion of the X-ray shell, we also see an offset in the radial profiles at different energies; the 0.5-0.6 keV peak dominated by O VII is closer to the shock front than that of the 0.8-3 keV emission-due to the longer times for heavier elements to reach ionization states where they produce strong X-ray emission.

Katsuda, Satoru [RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Long, Knox S.; Williams, Brian J. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Petre, Robert [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Reynolds, Stephen P. [Physics Department, North Carolina State University, Raleigh, NC 27695 (United States); Winkler, P. Frank, E-mail: katsuda@crab.riken.jp, E-mail: long@stsci.edu, E-mail: brian.j.williams@nasa.gov, E-mail: reynolds@ncsu.edu, E-mail: winkler@middlebury.edu [Department of Physics, Middlebury College, Middlebury, VT 05753 (United States)

2013-02-15

304

X-ray Proper Motions and Shock Speeds along the Northwest Rim of SN1006  

Science.gov (United States)

We report the results of an X-ray proper motion measurement for the NW rim of SN 1006, carried out by comparing Chandra observations from 2001 and 2012. The NW limb has predominantly thermal X-ray emission, and it is the only location in SN 1006 with signi cant optical emission: a thin, Balmer-dominated lament. For most of the NW rim, the proper motion is approximately equal to 0.30"yr(exp -1), essentially the same as has been measured from the H alpha lament. Isolated regions of the NW limb are dominated by nonthermal emission, and here the proper motion is much higher, 0:49"yr(exp -1), close to the value measured in X-rays along the much brighter NE limb, where the X-rays are overwhelmingly nonthermal. At the 2.2 kpc distance to SN 1006, the proper motions imply shock velocities of approximately 3000 kms(exp -1) and approximately 5000 kms(exp -1) in the thermal and nonthermal regions, respectively. A lower velocity behind the H alpha filament is consistent with the picture that SN 1006 is encountering denser gas in the NW, as is also suggested by its overall morphology. In the thermally-dominated portion of the X-ray shell, we also see an o set in the radial profiles at different energies; the 0.5-0.6 keV peak dominated by O VII is closer to the shock front than that of the 0.8-3 keV emission|due to the longer times for heavier elements to reach ionization states where they produce strong X-ray emission.

Katsuda, Satoru; Long, Knox S.; Petre, Robert; Reynolds, Stephen P.; Williams, Brian J.; Winkler, P. Frank

2012-01-01

305

In-plane and through-thickness shear characterization in S-RIM composites  

Energy Technology Data Exchange (ETDEWEB)

Variations of woven and stitched preform architectures to be used in Structural Reaction Injection Molding (S-RIM) are experimentally evaluated to determine shear properties and damage mechanisms. The selected systems represent commercially available mats where fiber tows are woven or stitched. Fiber tows are sources of stress concentrations and damage initiation sites both within the fiber-rich bundle and between bundles in the resin-rich regions. Crimp angles in woven preforms and cross-over regions in stitched preforms provide additional initiation sites. Microscopy observations are applied to evaluate the shear damage characteristics unique to each type of architecture. The Iosipescu G{sub xy} shear test is conducted on sets of S-RIM composite, to distinct stages of ultimate failure: 70%, 80%, 90% and 100%. In the post-test analysis, material sections are removed from the shear damaged zone in the specimen and polished. Optical and Scanning Electron Microscopy techniques are then implemented to capture the initiation and propagation of shear damage within the resin and resin/fiber interface. This technique provides a time trace of shear damage that culminates in ultimate shear failure of composite materials. In addition, a procedure for determination of G{sub xz} and G{sub yz} properties is developed. In the approach, identical laminates are bonded through the thickness to achieve a 19 mm total height. Then Iosipescu specimens are sliced through the thickness of the bonded laminates. Because of woven fiber bundles in the composite, several post-test computations are required for accurate interpretation of the shear test data. These include strain transformations and normalization techniques for specimens with different two architecture.

Walsh, T.J. [Hydril Co., Houston, TX (United States); Ochoa, O.O. [Texas A and M Univ., College Station, TX (United States). Center for Mechanics of Composites

1995-10-01

306

MRI of degenerative bone marrow lesions in experimental osteoarthritis of canine knee joints  

International Nuclear Information System (INIS)

Objective. The objective of this study was to determine the value of MRI in the detection of degenerative bone marrow abnormalities in an animal osteoarthritis model. Design. In 10 dogs with experimentally induced unilateral osteoarthritis of the knee, MRI was performed using two-dimensional spin-echo (2D-SE) and three-dimensional gradient-echo (3D-GE) imaging. Contrast enhanced T1-weighted 2D-SE sequences were also obtained after injection of gadolinium-DTPA. The results were compared with the gross and histopathologic findings and with radiography. Results. Histopathologic specimens revealed 21 osteosclerotic lesions and 5 intraosseous cysts. On 2D-SE images, 24 of 26 lesions were detected, while 21 of 26 lesions were identified on 2D-GE sequences. Radiography, including conventional tomography, demonstrated 9 of 26 lesions. Regardless of the sequence weighting, all osteosclerotic lesions appeared hypointense on MRI. Signal loss in bone sclerosis resulted primarily from the reduction of intact fat marrow, the increased bone density being of secondary importance. Quantitative signal analysis allowed approximate estimation of the grade of sclerosis. On postcontrast images, sclerotic bone remained hypointense, although significant but non-specific enhancement relative to the normal fat marrow was observed. The extent of contrast enhancement did not correlate with the grade of osteosclerosis. All five cysts were readily diagnosed by MRI. Cysts displayed either central or marginal contrast enhancement within their cavities. Conclusions. MRI provides a sensitive method for the diagnosis of osteoarthritic bone abnormalities, allowing their differentiation from most non-degenerative subarticular lesions. (orig.). With 1 tab

1996-07-01

307

Bisphosphonate-Related Osteonecrosis of the Jaw Bone: Radiological Pattern and the Potential Role of CBCT in Early Diagnosis  

Science.gov (United States)

ABSTRACT Objectives To systematize the clinico-radiological symptoms and course of bisphosphonate-related osteonecrosis of jaw bone and toevaluate the diagnostic potential of various radiological techniques to detect mild osteonecrosis in each stage of the disease. Material and Methods The sample consisted of 22 patients previously diagnosed with extraoral malignant disease. Diagnosis was based on a clinical examination in conjunction to digital panoramic radiography and cone beam computed tomography (CBCT). Two dentomaxillofacial radiologists reviewed all images. Results Twenty patients showed mandibular involvement clinically, while two others had a maxillary involvement. Four stages of the disease were proposed based on the clinico-radiological findings. Subclinical cortical and lamina dura thickening was detected with only three-dimensional CBCT and periapical images, while ulceration and cortical bone thickening was detected only by three-dimensional CBCT. Mixed sclerotic, lytic bone destruction involving alveolar and basal bone with or without encroachment on the mandibular canal, pathological mandibular fractures were detected by two-dimensional panoramic and three-dimensional CBCT images. Other findings are non healing extraction sockets, periapical radiolucencies, osteolysis, sequestra, oroantral fistula, and periosteal new bone formation. Conclusions The present study showed that bisphosphonate-related osteonecrosis of jaw bone occurs in four distinct clinico-radiological stages. For mild cases, panoramic image diagnosis was much less obvious, whereas cone beam computed tomography was able to fully characterise the bony lesions and describe their extent and involvement of neighbouring structures in all cases. Thus cone beam computed tomography might better contribute to the prevention of bisphosphonate-related osteonecrosis of jaw bone as well to the disease management.

Agbaje, Jimoh Olubanwo; Jacobs, Reinhilde; Verhaeghe, Vicky; Velde, Filip Vande; Vinckier, Frans

2010-01-01

308

Bisphosphonate-Related Osteonecrosis of the Jaw Bone: Radiological Pattern and the Potential Role of CBCT in Early Diagnosis  

Directory of Open Access Journals (Sweden)

Full Text Available Objectives: To systematize the clinico-radiological symptoms and course of bisphosphonate-related osteonecrosis of jaw bone and to evaluate the diagnostic potential of various radiological techniques to detect mild osteonecrosis in each stage of the disease.Material and Methods: The sample consisted of 22 patients previously diagnosed with extraoral malignant disease. Diagnosis was based on a clinical examination in conjunction to digital panoramic radiography and cone beam computed tomography (CBCT. Two dentomaxillofacial radiologists reviewed all images.Results: Twenty patients showed mandibular involvement clinically, while two others had a maxillary involvement. Four stages of the disease were proposed based on the clinico-radiological findings. Subclinical cortical and lamina dura thickening was detected with only three-dimensional CBCT and periapical images, while ulceration and cortical bone thickening was detected only by three-dimensional CBCT. Mixed sclerotic, lytic bone destruction involving alveolar and basal bone with or without encroachment on the mandibular canal, pathological mandibular fractures were detected by two-dimensional panoramic and three-dimensional CBCT images. Other findings are non healing extraction sockets, periapical radiolucencies, osteolysis, sequestra, oroantral fistula, and periosteal new bone formation.Conclusions: The present study showed that bisphosphonate-related osteonecrosis of jaw bone occurs in four distinct clinico-radiological stages. For mild cases, panoramic image diagnosis was much less obvious, whereas cone beam computed tomography was able to fully characterise the bony lesions and describe their extent and involvement of neighbouring structures in all cases. Thus cone beam computed tomography might better contribute to the prevention of bisphosphonate-related osteonecrosis of jaw bone as well to the disease management.

James Olutayo

2010-04-01

309

Apparatus for efficient sidewall containment of molten metal with horizontal alternating magnetic fields utilizing low reluctance rims  

Energy Technology Data Exchange (ETDEWEB)

A method and apparatus for casting sheets of metal from molten metal. The apparatus includes a containment structure having an open side, a horizontal alternating magnetic field generating structure and rollers including low reluctance rim structures. The magnetic field and the rollers help contain the molten metal from leaking out of the containment structure.

Praeg, Walter F. (Palos Park, IL)

1999-01-01

310

RIMS (real-time imprint monitoring by scattering of light) study of pressure, temperature and resist effects on nanoimprint lithography  

Energy Technology Data Exchange (ETDEWEB)

To optimize nanoimprint lithography (NIL), it is essential to be able to characterize and control the NIL process in situ and in real time. Recently we have developed a real-time imprint monitoring by the scattering-of-light (RIMS) approach, which allows us to detect the degree of resist deformation and the duration of resist penetration by a mould during the imprint process in real time. In this paper we report the performances of RIMS under a broad range of working conditions. RIMS data shows that the resist penetration is facilitated by increasing processing temperature, pressure and the resist film thickness; a prolonged pre-NIL resist baking step, on the other hand, has the effect of slowing it down. Our results provide further demonstration of the effectiveness of this method under different working conditions. RIMS measurements show not only how long an imprint takes to complete, but also how an imprint progresses with time and how it is affected by differences in processing parameters. These measurements provide information crucial for a better understanding and process optimization in NIL.

Yu Zhaoning; Gao He; Chou, Stephen Y [NanoStructure Laboratory, Department of Electrical Engineering, Princeton University, Princeton, NJ 08544 (United States)

2007-02-14

311

RIMS (real-time imprint monitoring by scattering of light) study of pressure, temperature and resist effects on nanoimprint lithography  

International Nuclear Information System (INIS)

To optimize nanoimprint lithography (NIL), it is essential to be able to characterize and control the NIL process in situ and in real time. Recently we have developed a real-time imprint monitoring by the scattering-of-light (RIMS) approach, which allows us to detect the degree of resist deformation and the duration of resist penetration by a mould during the imprint process in real time. In this paper we report the performances of RIMS under a broad range of working conditions. RIMS data shows that the resist penetration is facilitated by increasing processing temperature, pressure and the resist film thickness; a prolonged pre-NIL resist baking step, on the other hand, has the effect of slowing it down. Our results provide further demonstration of the effectiveness of this method under different working conditions. RIMS measurements show not only how long an imprint takes to complete, but also how an imprint progresses with time and how it is affected by differences in processing parameters. These measurements provide information crucial for a better understanding and process optimization in NIL

2007-02-14

312

Silica-rich Igneous Rims Around Magnesian Chondrules in CR Carbonaceous Chondrites: Evidence for Fractional Condensation During Chondrule Formation  

Science.gov (United States)

Type I chondrules in CRs are surrounded by silica-rich igneous rims which may have formed by gas-solid condensation of SiO2-rich materials onto chondrule surfaces and subsequent incomplete melting, or by direct SiO condensation into chondrule melts.

Krot, A. N.; Libourel, G.; Goodrich, C. A.; Petaev, M. I.; Killgore, M.

2003-03-01

313

Thermal and fluid processes of a thin melt zone during femtosecond laser ablation of glass: the formation of rims by single laser pulses  

International Nuclear Information System (INIS)

We study the formation mechanism of rims created around femtosecond laser ablated craters on glass. Experimental studies of the surface morphology reveal that a thin rim is formed around the smooth craters and is raised above the undamaged surface by about 50-100 nm. To investigate the mechanism of rim formation following a single ultrafast laser pulse, we perform a one-dimensional theoretical analysis of the thermal and fluid processes involved in the ablation process. The results indicate the existence of a very thin melted zone below the surface and suggest that the rim is formed by the high pressure plasma producing a pressure-driven fluid motion of the molten material outwards from the centre of the crater. The numerical solutions of pressure-driven fluid motion of the thin melt demonstrate that the melt can flow to the crater edge and form a rim within the first nanoseconds of the ablation process. The possibility that a tall rim can be formed during the initial stages of the plasma is suggestive that the rim may tilt outwards towards the low pressure region creating a resolidified melt splash as observed in the experiments. The possibility of controlling or suppressing the rim formation is discussed also

2007-03-07

314

Modification of the upper rim of homooxacalix[3]arenes and complexation between a nitrohomooxacalix[3]arene derivative and n-hexylamine.  

Science.gov (United States)

Several functional groups were introduced on the upper rim of (lower rim free) homooxacalix[3]arene for the first time. The swinging nitrohomooxacalix[3]arene host 1 was fixed in the cone conformation by complexation with n-hexylamine. PMID:12423145

Tsubaki, Kazunori; Otsubo, Tadamune; Morimoto, Tatsuya; Maruoka, Hiromi; Furukawa, Mika; Momose, Yashima; Shang, Muhong; Fuji, Kaoru

2002-11-15

315

Nd and Sr isotope compositions in modern and fossil bones - Proxies for vertebrate provenance and taphonomy  

Science.gov (United States)

Rare earth elements (REE), while not essential for the physiologic functions of animals, are ingested and incorporated in ppb concentrations in bones and teeth. Nd isotope compositions of modern bones of animals from isotopically distinct habitats demonstrate that the 143Nd/ 144Nd of the apatite can be used as a fingerprint for bedrock geology or ambient water mass. This potentially allows the provenance and migration of extant vertebrates to be traced, similar to the use of Sr isotopes. Although REE may be enriched by up to 5 orders of magnitude during diagenesis and recrystallization of bone apatite, in vivo143Nd/ 144Nd may be preserved in the inner cortex of fossil bones or enamel. However, tracking the provenance of ancient or extinct vertebrates is possible only for well-preserved archeological and paleontological skeletal remains with in vivo-like Nd contents at the ppb-level. Intra-bone and -tooth REE analysis can be used to screen for appropriate areas. Large intra-bone Nd concentration gradients of 10 1-10 3 are often measured. Nd concentrations in the inner bone cortex increase over timescales of millions of years, while bone rims may be enriched over millenial timescales. Nevertheless, ? Nd values are often similar within one ? Nd unit within a single bone. Larger intra-bone differences in specimens may either reflect a partial preservation of in vivo values or changing ? Nd values of the diagenetic fluid during fossilization. However, most fossil specimens and the outer rims of bones will record taphonomic 143Nd/ 144Nd incorporated post mortem during diagenesis. Unlike REE patterns, 143Nd/ 144Nd are not biased by fractionation processes during REE-uptake into the apatite crystal lattice, hence the ? Nd value is an important tracer for taphonomy and reworking. Bones and teeth from autochthonous fossil assemblages have small variations of ±1 ? Nd unit only. In contrast, fossil bones and teeth from over 20 different marine and terrestrial fossil sites have a total range of ? Nd values from -13.0 to 4.9 ( n = 80), often matching the composition of the embedding sediment. This implies that the surrounding sediment is the source of Nd in the fossil bones and that the specimens of this study seem not to have been reworked. Differences in ? Nd values between skeletal remains and embedding sediment may either indicate reworking of fossils and/or a REE-uptake from a diagenetic fluid with non-sediment derived ? Nd values. The latter often applies to fossil shark teeth, which may preserve paleo-seawater values. Complementary to ? Nd values, 87Sr/ 86Sr can help to further constrain the fossil provenance and reworking.

Tütken, Thomas; Vennemann, Torsten W.; Pfretzschner, Hans-U.

2011-10-01

316

Experimental study on the rim-enhancing lesion of rabbit brain abscess : MR imaging and histopathologic correlation  

Energy Technology Data Exchange (ETDEWEB)

To evaluate on the basis of histopathologic carrelation the MR findings of mature brain abscess in the rabbit, with particular attention to rim-enhancing lesions. The evolution of abscess formation was obtained by the direct inoculation of Staphylococcus aureus into the gray-white matter junctions of the brains of 16 rabbits. The stages of brain abscesses were divided into four : early cerebritis (days 1 to 5 after inoculation of the organism);late cerebritis (days 6 to 14);early capsular (days 16 to 21);and late capsular (days 22 to 28). The available MR images showed 14 cases at the stage of early cerebritis, seven at the late cerebritis stage, three at the early capsular, and one at the late capsular stage. According to the known pathology of brain abscesses and on the basis of both MR imaging and histopathologic findings, the lesions were grouped according to whether they were found in the central necrotic, border, or peripheral zone. We analyzed the patterns of rim-enhancement (completeness of the rim, thickness, and margin) and the signal intensities of the abscess walls on MR images at each stage. Histopathologic correlation was performed in one case of each stage. We evaluated the presence or absence and degree of infiltration by inflammatory granulation tissue, microhemorrhage, reticulin, collagen, and hemosiderin of the abscess walls. Rim-enhancing lesions were present in three of 14 cases at the late cerebritis stage, in all three cases at the early capsular, in one at the late capsular, but in none at the early cerebritis stage. The enhancing pattern of the late cerebritis stage was irregular-margined incomplete rim-enhancement, with irregular thickness of the abscess walls (3/3). The enhancing pattern of the capsular stages was well-defined, complete rim-enhancement with uniform thickness of the abscess walls (3/4). The signal intensities of the abscess walls at the late cerebritis and early capsular stages were variable. The late capsular stage ws characterized by hypointensity of the abscess wall on both T1- and T2-weighted images. Histopathologically, the capsular stages were distinguished from the late cerebritis stage by the marked infiltration of reticulin and the presence of collagen in the abscess walls. The most conspicuous pathologic finding distinguishing the late from the early capsular stage was abundant infiltration of the abscess wall by collagen and hemosiderin. The enhancing pattern of a brain abscess with mature capsule formation was characterized by a well-defined, complete rim-enhancing abscess wall of uniform thickness. The mature abscess wall was hypointense on both T1- and T2-weighted images, may be explained by marked infiltration by mature collagen and hemosiderin.

Lee, Hee Jung; Suh, Soo Jhi; Kim, Sang Pyo; Joo, Yang Goo; Zeon, Seok Kil; Woo, Seong Ku [Keimyung Univ. School of Medicine, Taegu (Korea, Republic of)

1996-11-01

317

Experimental study on the rim-enhancing lesion of rabbit brain abscess : MR imaging and histopathologic correlation  

International Nuclear Information System (INIS)

To evaluate on the basis of histopathologic carrelation the MR findings of mature brain abscess in the rabbit, with particular attention to rim-enhancing lesions. The evolution of abscess formation was obtained by the direct inoculation of Staphylococcus aureus into the gray-white matter junctions of the brains of 16 rabbits. The stages of brain abscesses were divided into four : early cerebritis (days 1 to 5 after inoculation of the organism);late cerebritis (days 6 to 14);early capsular (days 16 to 21);and late capsular (days 22 to 28). The available MR images showed 14 cases at the stage of early cerebritis, seven at the late cerebritis stage, three at the early capsular, and one at the late capsular stage. According to the known pathology of brain abscesses and on the basis of both MR imaging and histopathologic findings, the lesions were grouped according to whether they were found in the central necrotic, border, or peripheral zone. We analyzed the patterns of rim-enhancement (completeness of the rim, thickness, and margin) and the signal intensities of the abscess walls on MR images at each stage. Histopathologic correlation was performed in one case of each stage. We evaluated the presence or absence and degree of infiltration by inflammatory granulation tissue, microhemorrhage, reticulin, collagen, and hemosiderin of the abscess walls. Rim-enhancing lesions were present in three of 14 cases at the late cerebritis stage, in all three cases at the early capsular, in one at the late capsular, but in none at the early cerebritis stage. The enhancing pattern of the late cerebritis stage was irregular-margined incomplete rim-enhancement, with irregular thickness of the abscess walls (3/3). The enhancing pattern of the capsular stages was well-defined, complete rim-enhancement with uniform thickness of the abscess walls (3/4). The signal intensities of the abscess walls at the late cerebritis and early capsular stages were variable. The late capsular stage ws characterized by hypointensity of the abscess wall on both T1- and T2-weighted images. Histopathologically, the capsular stages were distinguished from the late cerebritis stage by the marked infiltration of reticulin and the presence of collagen in the abscess walls. The most conspicuous pathologic finding distinguishing the late from the early capsular stage was abundant infiltration of the abscess wall by collagen and hemosiderin. The enhancing pattern of a brain abscess with mature capsule formation was characterized by a well-defined, complete rim-enhancing abscess wall of uniform thickness. The mature abscess wall was hypointense on both T1- and T2-weighted images, may be explained by marked infiltration by mature collagen and hemosiderin

1996-11-01

318

Are archaeological bones similar to modern bones  

International Nuclear Information System (INIS)

An assessment is made of the analytical reliability of the INAA determination of major and trace elements, using their short-lives radioisotopes in both regular and defatted modern cancellous bone, and in modern cortical bone. This modern bone information is then compared with analytical data for bones from Egyptian mummies ranging in age from approx. 2000 to approx. 3700 BP, and with normally-buried 11th century French bones. Diagenetic effects may readily be detected by the measurement of elevated quantities of V, Mn and Al in soil-contaminated bones. The Ca to P concentration ratios and the organic content may also be used to separate bone from diagenetically altered archeological specimens. (author)

1987-03-01

319

Bone scan in rheumatology  

International Nuclear Information System (INIS)

In this chapter a revision is made concerning different uses of bone scan in rheumatic diseases. These include reflex sympathetic dystrophy, osteomyelitis, spondyloarthropaties, metabolic bone diseases, avascular bone necrosis and bone injuries due to sports. There is as well some comments concerning pediatric pathology and orthopedics. (authors). 19 refs., 9 figs

1993-01-01

320

Bone marrow aspiration  

Digital Repository Infrastructure Vision for European Research (DRIVER)

PHOTOS 1-2: The bone marrow biopsy needle is used to perform biopsies of bone marrow but not the bone. It has a large handle facilitating introduction of the needle into bone and a stylet to prevent tissue coring. PHOTOS 3-4: Bone marrow aspiration biopsy provides information on the condition and activity of the haemopoietic cells in bone marrow. Bone marrow aspiration biopsy is indicated in cases where there is obvious or suggested dysfunctioning of the haemopoietic system but there is ins...

2007-01-01

 
 
 
 
321

[Imaging of bone metastases].  

Science.gov (United States)

Bone metastases are detected at initial diagnosis of cancer in 25% of cases and bone metastases are common in the course of a majority of cancer types. The spine and proximal long bones are the most affected sites. Knowledge of the basic radiological semiology is important to make the proper diagnosis of metastasis(s) bone(s), especially in situations in which the clinical context is not suggestive of metastases (such as cases where bone metastases are inaugural or cases of peripheral solitary metastasis). Tumor aggressiveness can be assessed at the level of the cortical bone and periosteum. Lodwick criteria are useful for the diagnosis of malignancy and tumor aggressiveness at initial diagnosis on plain radiographs, which are very important in the context of bone metastases. A CT scanner is required to confirm the malignancy of a bone lesion. MRI is complementary to the scanner including for the assessment of bone marrow involvement and tumor extensions. PMID:24184968

Amoretti, Nicolas; Thariat, Juliette; Nouri, Yasir; Foti, Pauline; Hericord, Olivier; Stolear, Sandy; Coco, Lucia; Hauger, Olivier; Huwart, Laurent; Boileau, Pascal

2013-11-01

322

Metastatic bone disease  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Metastatic bone disease is the most common malignancy of bone, it is estimated that 70% of all malignant bone tumors are metastatic in origin. At autopsy it has been reported between 30 to 85% of patients who die from cancer show occult skeletal metastases. Bone is the third most common site of metastatic process after lung and liver. 80% of metastatic bone disease arise from Ca of breast, prostate, lung, kidney and thyroid. Typical location are thoracolumbal spine, pelvis, ribs, skull and...

Hutagalung, Errol U.

2004-01-01

323

Basic bone radiology  

International Nuclear Information System (INIS)

This clinical book surveys the skeletal system as seen through radiological imaging. It emphasizing abnormalities, disease, and trauma, and includes vital information on bones, bone growth, and the cells involved in bone pathology. It covers many bone diseases and injuries which are rarely covered in medical texts, as well as descriptions of radiologic procedures that specifically relate to the skeleton. This edition includes many illustrations, information on MR imaging and CT scanning, and discussions of osteoporosis, dysplasias, and metabolic bone disease

1987-01-01

324

[Menopause and bone metabolism].  

Science.gov (United States)

Hypoestrogenemia in climacterium causes high turnover bone metabolism, relative dominance of bone resorption, and osteopenia. Women have severe bone loss in climacterium. The objective for the prevention of osteoporosis in this period is to detect the high risk women of osteoporosis with bone mineral densitometry or bone metabolic markers and to start the preventive therapy, i. e. food, exercise and drug, as soon as possible. Therefore, menopause is very important period to prevent osteoporosis in future. PMID:15775424

Kurabayashi, Takumi; Kato, Nozomi; Nagata, Hiroshi; Matsushita, Hiroshi; Tanaka, Kenichi

2002-09-01

325

Bone seeking radiopharmaceuticals  

International Nuclear Information System (INIS)

This review deals mainly with technetium bone scanning agents but it also pays some attention to the optimization of rhenium bone seeking agents. Aspects covered include characterization methods used for bone seeking radiopharmaceuticals, the characterization of technetium bone seeking radiopharmaceuticals, the interaction of technetium radiopharmaceuticals with blood proteins, adsorption of technetium radiopharmaceuticals on hydroxyapatite, interaction of technetium radiopharmaceuticals with Calvaria, in vivo process occurring after i.v. infection of technetium radiopharmaceuticals and the optimization of bone scanning agents. (U.K.)

1990-01-01

326

Anorexia nervosa and bone.  

Science.gov (United States)

Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone mass, impaired bone structure, and reduced bone strength, all of which contribute to increased fracture risk. Adolescents with AN have decreased rates of bone accrual compared with normal-weight controls, raising additional concerns of suboptimal peak bone mass and future bone health in this age group. Changes in lean mass and compartmental fat depots, and hormonal alterations secondary to nutritional factors contribute to impaired bone metabolism in AN. The best strategy to improve bone density is to regain weight and menstrual function. Oral estrogen-progesterone combinations are not effective in increasing bone density in adults or adolescents with AN, and transdermal testosterone replacement is not effective in increasing bone density in adult women with AN. However, physiological estrogen replacement as transdermal estradiol with cyclic progesterone does increase bone accrual rates in adolescents with AN to approximate that in normal-weight controls, leading to a maintenance of bone density Z-scores. A recent study has shown that risedronate increases bone density at the spine and hip in adult women with AN. However, bisphosphonates should be used with great caution in women of reproductive age, given their long half-life and potential for teratogenicity, and should be considered only in patients with low bone density and clinically significant fractures when non-pharmacological therapies for weight gain are ineffective. Further studies are necessary to determine the best therapeutic strategies for low bone density in AN. PMID:24898127

Misra, Madhusmita; Klibanski, Anne

2014-06-01

327

Interactive Mapping on Virtual Terrain Models Using RIMS (Real-time, Interactive Mapping System)  

Science.gov (United States)

Recent and ongoing space missions are yielding new multispectral data for the surfaces of Earth and other planets at unprecedented rates and spatial resolution. With their high spatial resolution and widespread coverage, these data have opened new frontiers in observational Earth and planetary science. But they have also precipitated an acute need for new analytical techniques. To address this problem, we have developed RIMS, a Real-time, Interactive Mapping System that allows scientists to visualize, interact with, and map directly on, three-dimensional (3D) displays of georeferenced texture data, such as multispectral satellite imagery, that is draped over a surface representation derived from digital elevation data. The system uses a quadtree-based multiresolution method to render in real time high-resolution (3 to 10 m/pixel) data over large (800 km by 800 km) spatial areas. It allows users to map inside this interactive environment by generating georeferenced and attributed vector-based elements that are draped over the topography. We explain the technique using 15 m ASTER stereo-data from Iraq, P.R. China, and other remote locations because our particular motivation is to develop a technique that permits the detailed (10 m to 1000 m) neotectonic mapping over large (100 km to 1000 km long) active fault systems that is needed to better understand active continental deformation on Earth. RIMS also includes a virtual geologic compass that allows users to fit a plane to geologic surfaces and thereby measure their orientations. It also includes tools that allow 3D surface reconstruction of deformed and partially eroded surfaces such as folded bedding planes. These georeferenced map and measurement data can be exported to, or imported from, a standard GIS (geographic information systems) file format. Our interactive, 3D visualization and analysis system is designed for those who study planetary surfaces, including neotectonic geologists, geomorphologists, marine geophysicists, and planetary scientists. The strength of our system is that it combines interactive rendering with interactive mapping and measurement of features observed in topographic and texture data. Comparison with commercially available software indicates that our system improves mapping accuracy and efficiency. More importantly, it enables Earth scientists to rapidly achieve a deeper level of understanding of remotely sensed data, as observations can be made that are not possible with existing systems.

Bernardin, T.; Cowgill, E.; Gold, R. D.; Hamann, B.; Kreylos, O.; Schmitt, A.

2006-12-01

328

Saccular function in otosclerosis patients: bone conducted-vestibular evoked myogenic potential analysis.  

Science.gov (United States)

Vestibular involvements have long been observed in otosclerotic patients. Among vestibular structures saccule has the closest anatomical proximity to the sclerotic foci, so it is the most prone vestibular structure to be affected during the otosclerosis process. The aim of this study was to investigate the saccular function in patients suffering from otosclerosis, by means of Vestibular Evoked Myogenic Potential (VEMP). The material consisted of 30 otosclerosis patients and 20 control subjects. All participants underwent audiometric and VEMP testing. Analysis of tests results revealed that the mean values of Air-Conducted Pure Tone Average (AC-PTA) and Bone-Conducted Pure Tone Average (BC-PTA) in patients were 45.28 ± 15.57 and 19.68 ± 10.91, respectively and calculated 4 frequencies Air Bone Gap (ABG) was 25.64 ± 9.95. The VEMP response was absent in 14 (28.57%) otosclerotic ears. A statistically significant increase in latency of the p13 was found in the affected ears (P=0.004), differences in n23 latency did not reach a statistically significant level (P=0.112). Disparities in amplitude of p13-n23 in between two study groups was statistically meaningful (P=0.009), indicating that the patients with otosclerosis had lower amplitudes. This study tends to suggest that due to the direct biotoxic effect of the materials released from the otosclerosis foci on saccular receptors, there might be a possibility of vestibular dysfunction in otosclerotic patients. PMID:24659067

Amali, Amin; Mahdi, Parvane; Karimi Yazdi, Alireza; Khorsandi Ashtiyani, Mohammad Taghi; Yazdani, Nasrin; Vakili, Varasteh; Pourbakht, Akram

2014-01-01

329

Studies on the abnormal accumulations in vertebrae found on the bone scintigram in cancer patients  

International Nuclear Information System (INIS)

From Jan. 1975 to Dec. 1977, 700 patients with various types of cancer were examined by bone scanning with sup(99m)Tc-phosphate compounds for metastatic bone lesions at the National Cancer Center Hospital. Among these selected 156 patients, significant accumulations were found in 120, and equivocal in 21. The remaining 15 showed both significant and equivocal accumulations. In 116 out of 135 (120 + 15) patients, the significant accumulations were due to metastases; and in 19 out of 36 (21 + 15) patients, the equivocal accumulations were due to metastases. Our careful investigation disclosed that some of the benign conditions could present somewhat different scintigraphic patterns from the metastases. These are as follows; (1) a cushion-like accumulation in the intervertebral space in the cases with disc degeneration, which is occasionally noted also in the cases with collapse of the vertebral body, (2) an irregular marginal accumulation of the vertebral body with an occasional cushion-like accumulation in the intervertebral space in the cases spondylosis deformans, (3) a vague and equivocal accumulation covering an entire vertebral body with an occasional extension to the next vertebral body in the cases with spondylosis deformans, (4) symmetrical accumulations in the intervertebral joints due to sclerotic changes. The 4th pattern mentioned above may be noted in the cases with metastases also. (author)

1980-01-01

330

Regeneration of Mastoid Air Cells in Vivo Using Autologous Cortical Bone  

Directory of Open Access Journals (Sweden)

Full Text Available Purpose: This was a preliminary study to assess surgical construction and regeneration of mastoid air cells in the treatment of cholesteatoma. Methods: Two-stage tympanoplasty with mastoidectomy was performed in four cases of unilateral cholesteatoma with sclerotic mastoid. During the first-stage operation, small fragments of autologous cortical bone were inserted into the cavity after mastoidectomy to form a honeycomb-like structure. Reconstruction of the lateral wall of the mastoid cavity was performed using the mastoid cortical bony plate. Pre- and postoperative mastoid volume was evaluated by three-dimensional reconstruction based on high-resolution computed tomography (HR-CT images. Results: HR-CT images after the first-stage operation showed that mastoid volume had increased in all subjects. Macroscopic inspection during the second-stage operation revealed that the honeycomb-like structure made of bony fragments and covered by thin mucosa in the mastoid cavity was stable, with no evidence of effusion or granulation tissue. No retraction of the eardrum, middle ear effusion or recurrence of cholesteatoma was observed, and the hearing level on a pure-tone audiogram was improved in any subject 60 - 94 months after the second-stage operation. Conclusion: Surgical construction and regeneration of mastoid air cells using autologous cortical bone can be useful in treatment of cholesteatoma with arrested mastoid pneumatization.

Ken-ichi Kaneko

2012-11-01

331

Ascaridíase das vias urinárias: um caso de penetração de Ascaris lumbricoides através do rim  

Directory of Open Access Journals (Sweden)

Full Text Available Uma criança de 2 anos com desnutrição grave e infestação intestinal maciça por Ascaris lumbricoides, apresentou como complicação, documentada em necrópsia, a migração de vermes adultos para a cavidade peritonial e penetração aberrante de dois parasitos através do rim esquerdo. Os Ascaris ficaram alojados no sistema pielo-ureteral, determinando grave infecção purulenta e obstrução ureteral. Esta complicação demonstra a capacidade agressiva de vermes erráticos na cavidade peritonial, com possibilidade de perfurar mesmo uma víscera sólida. São comentados os fatores que facilitaram a migração dos vermes por aqueles órgãos.The author reports an autopsy case of a two year old child with massive intestinal ascariasis and malnutrition, presenting the migration of two adult Ascaris lumbricoides through the left kidney into the pyelo-ureteral system. As a result she developed acute pyelonephritis and ureteral obstruction. Previously the worms left the intestine into the peritoneal cavity (lesser sac through a duodenal cleft. Factors contributing to the migration of the roundworms by those pathways are discussed.

Mario Caymmi Gomes

1977-10-01

332

Building for the Pacific Rim Countries. Energy-efficient building strategies for hot, humid climates  

Energy Technology Data Exchange (ETDEWEB)

This book has been published by the Solar Energy Industries Association (SEIA), the US trade association of the solar thermal, photovoltaic, and passive solar manufacturers, distributors, and component suppliers. Its purpose is to help architects, builders, and developers construct energy-efficient homes in hot humid climates like the Pacific Rim Countries, and to allow occupants of these homes to enjoy enhanced comfort without reliance on mechanical air-conditioning systems. Two important factors are addressed in this book. First, the past few years have seen a tremendous increase in practical applications of new research. The current popularity of ceiling paddle fans, attic radiant barriers and natural daylighting attest to the importance of keeping up with the latest concepts in energy-reduction and comfort-awareness. Professionals who have been in the field for the past few years may be unaware of the latest research findings--some of which dramatically alter prior thinking on such subjects as natural ventilation or mechanical air conditioning. The second factor is the importance of site-specific characteristics, which greatly affect building strategies and designs. A thorough understanding of the climate is a prerequisite to good building design. Such factors as temperature, humidity, wind speed and direction, and solar radiation must be understood and properly integrated into the design for the home to be truly energy-efficient.

Sheinkopf, K. [ed.

1991-09-01

333

An Investigation on the Morphological Evolution of Bright-Rimmed Clouds  

Science.gov (United States)

A new radiative driven implosion (RDI) model based on smoothed particle hydrodynamics technique is developed and applied to investigate the morphological evolutions of molecular clouds under the effect of ionizing radiation. This model self-consistently includes the self-gravity of the cloud in the hydrodynamical evolution, the UV radiation component in the radiation transferring equations, the relevant heating and cooling mechanisms in the energy evolution, and a comprehensive chemical network. The simulation results reveal that under the effect of ionizing radiation, a molecular cloud may evolve through different evolutionary sequences. Depending on its initial gravitational state, the evolution of a molecular cloud does not necessarily follow a complete morphological evolution sequence from type A?B?C, as described by previous RDI models. When confronted with observations, the simulation results provide satisfactory physical explanations for a series of puzzles derived from bright-rimmed clouds observations. The consistency of the modeling results with observations shows that the self-gravity of a molecular cloud should not be neglected in any investigation on the dynamical evolution of molecular clouds when they are exposed to ionizing radiation.

Miao, Jingqi; White, Glenn J.; Thompson, M. A.; Nelson, Richard P.

2009-02-01

334

The Chandra View of the Triggered Star Formation in Bright Rimmed Clouds  

Science.gov (United States)

The formation of mamy stars in the Galaxy appears to be triggered by some external compression processes such as OB ionization, winds or supernovae shocks. However, quantitative understanding of triggering processes is still primitive. The radiation driven implosion (RDI) is currently considered as the most observationally testable model using bright rimmed clouds (BRCs) on the edges of large HII regions. We have made several short observations with the Chandra X-ray Observatory to elucidate the mechanism, efficiency and stellar populations produced by small-scale triggered star formation around HII regions. X-ray selection is effective in tracing triggered low mass stars from protostellar through disk-free stages, both embedded in the cloud and in the unobscured cloud vicinity. The results of these studies are presented and generally support the RDI model. Triggering by HII region shocks is not restricted to a single episode, but can continue for millions of years. We discuss plans for the collection of BRC young star samples at different morphological stages of the triggering and cloud ablation process to test RDI predictions and to quantify the role of RDI in Galactic star formation.

Feigelson, Eric; Getman, K.

2009-01-01

335

The difference in translaminar pressure gradient and neuroretinal rim area in glaucoma and healthy subjects.  

Science.gov (United States)

Purpose. To assess differences in translaminar pressure gradient (TPG) and neuroretinal rim area (NRA) in patients with normal tension glaucoma (NTG), high tension glaucoma (HTG), and healthy controls. Methods. 27 patients with NTG, HTG, and healthy controls were included in the prospective pilot study (each group consisted of 9 patients). Intraocular pressure (IOP), intracranial pressure (ICP), and confocal laser scanning tomography were assessed. TPG was calculated as the difference of IOP minus ICP. ICP was measured using noninvasive two-depth transcranial Doppler device. The level of significance P 0.05). The difference between TPG for healthy (5.4(7.7)?mmHg) and glaucomatous eyes (NTG 6.3(3.1)?mmHg, HTG 15.7(7.7)?mmHg) was statistically significant (P < 0.001). Higher TPG was correlated with decreased NRA (r = -0.83; P = 0.01) in the NTG group. Conclusion. Translaminar pressure gradient was higher in glaucoma patients. Reduction of NRA was related to higher TPG in NTG patients. Further prospective studies are warranted to investigate the involvement of TPG in glaucoma management. PMID:24876948

Siaudvytyte, Lina; Januleviciene, Ingrida; Ragauskas, Arminas; Bartusis, Laimonas; Meiliuniene, Indre; Siesky, Brent; Harris, Alon

2014-01-01

336

Investigations into the effectiveness of water infusion using the radio imaging method (RIM)  

Energy Technology Data Exchange (ETDEWEB)

Three different methods of water infusion (for dust control), were studied to ascertain the most appropriate for the prevailing conditions at BHP Steels Appin, Colliery, i.e. 'non-bagged', 'semi-bagged', and 'fully-bagged' methods. The 'non-bagged' method basically consists of pumping water into a bore and sealing the extremities of the holes. The 'fully-bagged' method of water infusion involves the sealing of boreholes at spacings of approximately 16 to 20m down the borehole. This grouting procedure effectively installs obstacles in the path of the water. The 'semi-bagged' method involves the sealing of the borehole at approximately 15 to 20 metres from both ends of the hole. This leaves the rest of the bore open. RIM (Radio Imaging Method) was used to: quantify the extent of water infusion; determine the effectiveness of the different infusion methods; and to improve the overall understanding of water infusion technology. The semi-bagged method was the most successful with no leakage into the gate roads. 2 refs., 10 figs., 2 tabs.

Doyle, R.; Thomson, S.; Neil, M.; Price, W.; Young, J. (BHP Steel (Australia). Collieries Division)

1992-01-01

337

Bioclimate-Vegetation Interrelations along the Pacific Rim of North America  

Directory of Open Access Journals (Sweden)

Full Text Available This study was designed to examine relationships between climate and vegetation of the Pacific rim of North America, from the Mediterranean deserts of California to Alaska’s boreal taiga. Relations were inferred from temperature and rainfall data recorded at 457 weather stations and by sampling the vegetation around these stations. Climate data were used to construct climatograms, calculate forty one variables and detect main latitudinal and longitudinal gradients. In order to identify the best functions able to relate our variables, polynomial and non-polynomial regressions were performed. The k-means algorithm was the clustering method used to validate the variables that could best support our bioclimatic classification. The variable that best fitted our classification was finally used to prepare a discriminatory key for bioclimates. Across this extensive area three macrobioclimates were identified, Mediterranean, Temperate and Bo- real, within which we were able to distinguish nine bioclimates. Finally, we relate the different types of potential natural vegetation to each of these bioclimates and describe their floristic composition and physiognomy.

Manuel Peinado

2012-10-01

338

AN INVESTIGATION ON THE MORPHOLOGICAL EVOLUTION OF BRIGHT-RIMMED CLOUDS  

International Nuclear Information System (INIS)

A new radiative driven implosion (RDI) model based on smoothed particle hydrodynamics technique is developed and applied to investigate the morphological evolutions of molecular clouds under the effect of ionizing radiation. This model self-consistently includes the self-gravity of the cloud in the hydrodynamical evolution, the UV radiation component in the radiation transferring equations, the relevant heating and cooling mechanisms in the energy evolution, and a comprehensive chemical network. The simulation results reveal that under the effect of ionizing radiation, a molecular cloud may evolve through different evolutionary sequences. Depending on its initial gravitational state, the evolution of a molecular cloud does not necessarily follow a complete morphological evolution sequence from type A?B?C, as described by previous RDI models. When confronted with observations, the simulation results provide satisfactory physical explanations for a series of puzzles derived from bright-rimmed clouds observations. The consistency of the modeling results with observations shows that the self-gravity of a molecular cloud should not be neglected in any investigation on the dynamical evolution of molecular clouds when they are exposed to ionizing radiation.

2009-02-10

339

Aerial image-based design of rim phase-shift masks with annular illumination  

Science.gov (United States)

A wide variety of lithography enhancement techniques have been introduced in recent years. Each method has certain virtues, such as improving the resolution of tightly packed features or increasing the depth of focus for isolated ones. Normally, these schemes are analyzed for areas in which they work best. However, it is desirable to have a phase-shift method and illumination system which improves the depth of focus for a large variety of patterns. To satisfy both requirements, promising techniques must be biased to obtain the best process improvement. These issues are particularly relevant for masks with random logic. To address the two problems, we have developed an E-D tree based computer aided design system which analyzes phase-shift masks and illumination methods for one-dimensional features and calculates the proper bias for them. Our simulations concentrate on analyzing constant width lines and spaces of varying duty cycle. The results from analyzing the features illustrate that both phase-shifting masks and off-axis illumination have regions of reduced performance, or dead zones, in which the depth of focus is degraded. Examples of dead zones are evident with many types of phase-shift masks, such as attenuating, alternate aperture, and rim, and with illumination systems, such as annular illumination. Combinations of enhancement techniques, however, can reduce the effect.

Newmark, David M.; Garofalo, Joseph G.; Vaidya, Sheila

1993-08-01

340

Bassoon specifically controls presynaptic P/Q-type Ca(2+) channels via RIM-binding protein.  

Science.gov (United States)

Voltage-dependent Ca(2+) channels (CaVs) represent the principal source of Ca(2+) ions that trigger evoked neurotransmitter release from presynaptic boutons. Ca(2+) influx is mediated mainly via CaV2.1 (P/Q-type) and CaV2.2 (N-type) channels, which differ in their properties. Their relative contribution to synaptic transmission changes during development and tunes neurotransmission during synaptic plasticity. The mechanism of differential recruitment of CaV2.1 and CaV2.2 to release sites is largely unknown. Here, we show that the presynaptic scaffolding protein Bassoon localizes specifically CaV2.1 to active zones via molecular interaction with the RIM-binding proteins (RBPs). A genetic deletion of Bassoon or an acute interference with Bassoon-RBP interaction reduces synaptic abundance of CaV2.1, weakens P/Q-type Ca(2+) current-driven synaptic transmission, and results in higher relative contribution of neurotransmission dependent on CaV2.2. These data establish Bassoon as a major regulator of the molecular composition of the presynaptic neurotransmitter release sites. PMID:24698275

Davydova, Daria; Marini, Claudia; King, Claire; Klueva, Julia; Bischof, Ferdinand; Romorini, Stefano; Montenegro-Venegas, Carolina; Heine, Martin; Schneider, Romy; Schröder, Markus S; Altrock, Wilko D; Henneberger, Christian; Rusakov, Dmitri A; Gundelfinger, Eckart D; Fejtova, Anna

2014-04-01

 
 
 
 
341

Early radiologic detection of local recurrence after curettage and acrylic cementation of giant cell tumours  

Energy Technology Data Exchange (ETDEWEB)

Five patients with giant cell tumour of bone, treated with curettage and acrylic cementation, were suspected of having recurrence of tumour 6 months - 6 years after surgery. At repeat surgery, recurrence was histologically verified in three patients, and excluded in two. A review of the radiologic examinations of these patients showed that the only reliable sign of early recurrence showed that the only reliable sign of early recurrence was lysis or non-development of the sclerotic rim adjacent to the radiolucent zone between the cement and the cancellous bone, detectable on conventional radiographs and tomographs. Angiography and scintimetry were not reliable during the first year after the primary surgery.

Petersson, H.; Rydholm, A.; Persson, B.

1986-02-01

342

Early radiologic detection of local recurrence after curettage and acrylic cementation of giant cell tumours  

International Nuclear Information System (INIS)

Five patients with giant cell tumour of bone, treated with curettage and acrylic cementation, were suspected of having recurrence of tumour 6 months - 6 years after surgery. At repeat surgery, recurrence was histologically verified in three patients, and excluded in two. A review of the radiologic examinations of these patients showed that the only reliable sign of early recurrence showed that the only reliable sign of early recurrence was lysis or non-development of the sclerotic rim adjacent to the radiolucent zone between the cement and the cancellous bone, detectable on conventional radiographs and tomographs. Angiography and scintimetry were not reliable during the first year after the primary surgery. (orig.)

1986-01-01

343

Clinical data integration of distributed data sources using Health Level Seven (HL7 v3-RIM mapping  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Health information exchange and health information integration has become one of the top priorities for healthcare systems across institutions and hospitals. Most organizations and establishments implement health information exchange and integration in order to support meaningful information retrieval among their disparate healthcare systems. The challenges that prevent efficient health information integration for heterogeneous data sources are the lack of a common standard to support mapping across distributed data sources and the numerous and diverse healthcare domains. Health Level Seven (HL7 is a standards development organization which creates standards, but is itself not the standard. They create the Reference Information Model. RIM is developed by HL7's technical committees. It is a standardized abstract representation of HL7 data across all the domains of health care. In this article, we aim to present a design and a prototype implementation of HL7 v3-RIM mapping for information integration of distributed clinical data sources. The implementation enables the user to retrieve and search information that has been integrated using HL7 v3-RIM technology from disparate health care systems. Method and results We designed and developed a prototype implementation of HL7 v3-RIM mapping function to integrate distributed clinical data sources using R-MIM classes from HL7 v3-RIM as a global view along with a collaborative centralized web-based mapping tool to tackle the evolution of both global and local schemas. Our prototype was implemented and integrated with a Clinical Database management Systems CDMS as a plug-in module. We tested the prototype system with some use case scenarios for distributed clinical data sources across several legacy CDMS. The results have been effective in improving information delivery, completing tasks that would have been otherwise difficult to accomplish, and reducing the time required to finish tasks which are used in collaborative information retrieval and sharing with other systems. Conclusions We created a prototype implementation of HL7 v3-RIM mapping for information integration between distributed clinical data sources to promote collaborative healthcare and translational research. The prototype has effectively and efficiently ensured the accuracy of the information and knowledge extractions for systems that have been integrated

Viangteeravat Teeradache

2011-11-01

344

Enfermedad de Paget en Chile: una serie de 15 pacientes / Paget disease of bone: Report of 15 cases  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish [...] Abstract in english Background: Paget disease of bone (PD) is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and m [...] ethods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained data from 15 patients with PD (ten males, eight Chilean, six European and one Asian), eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit). Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Méd Chile 2003; 131: 491-7).

Gilberto, González V; Francisca, Brusco G; Eugenio, Arteaga U; José, Rodríguez P; Sergio, Jacobelli G; Loreto, Massardo V; Cristián, Ortiz M; Oscar, Contreras O.

345

NMR spectroscopy of bone and bone substitutes  

Energy Technology Data Exchange (ETDEWEB)

High resolution solid state NMR spectroscopy appears as a powerful method for a better understanding of bone structure and bone implant. In particular it is efficient to estimate osteoformation via bioceramics bone colonization. In this work {sup 31}P, {sup 1}H NMR are used to the analysis of different type of bioceramics, to follow the transformation of calcium phosphate ceramics versus implantation time, to examine the influence of a protein. (orig.)

Legrand, A.P.; Bresson, B. [ESA, Paris (France). Lab. de Physique Quantique; Bouler, J.M. [INSERM, Nantes (France). Lab. de Recherche sur les Materiaux d' Interet Biologique

2001-07-01

346

Roentgenological semiotics of bone and bone joints pathology  

International Nuclear Information System (INIS)

Physiologic and pathologic processes in bones followed by alternations of bone structure and reflected on roentgenograms are considered and described. Most frequent reasons for roentgenodiagnosis errors in diseases of bone and bone joint apparatus are presented

1984-01-01

347

Comparative imaging study for soft tissue changes in osteomyelitis and malignant bone tumor  

International Nuclear Information System (INIS)

Objective: To investigate the value of the imaging findings of soft tissue abnormality in the differential diagnosis between osteomyelitis and malignant bone tumor. Methods: The CT and MRI findings of soft tissue changes in 57 cases of osteomyelitis and 70 cases of malignant bone tumor were retrospectively defined,observed, recorded and statistically analyzed. Results: In 57 cases of osteomyelitis, 54 cases were examined with CT, and soft tissue swelling was presented in 52 cases (degree I in 19 cases, degree II in 16 cases, degree III in 17 cases). Abscess-like cysts in soft tissue occurred in 6 cases, masses in 5, air in 1, fat-fluid level in 1 and sinus tract in 1. Among 14 cases examined with MR imaging, soft tissue swelling was presented in all cases (degree I in 2 cases, degree II in 6 cases and degree III in 6 cases). Abscess-like cysts appeared in 3 cases and showed high signal in diffusion weighted imaging, mass in 1 and fat-fluid level in 1. Among 54 cases examined with CT in 70 cases of malignant bone tumor, soft tissue swelling was presented in 44 cases (degree I in 29 cases, degree II in 12 cases, degree III in 3 cases). Soft tissue masses appeared in 49 cases, bone shell and shell-like calcification in 16 cases, and neoplastic bone and neoplastic calcified cartilage within soft tissue mass in 25 cases. Among 49 cases examined with MR imaging, soft tissue swelling was presented in 46 cases (degree I in 21 cases, degree II in 17 cases and degree III in 8 cases), and soft tissue masses appeared in 43 cases. The degree of soft tissue swelling and the occurrence of abscess-like cyst, mass, bone shell or shell-liked calcification in the rim of mass, neoplastic bone or neoplastic calcified cartilage in masses showed significant difference (P<0.05) between osteomyelitis group and malignant bone tumor group on CT examination. The degree of Soft tissue swelling and the occurrence frequency of abscess-like cysts and mass were significantly different (P<0.05) between osteomyelitis group and malignant bone tumor group on MR examination. Conclusion: The degree of soft tissue swelling and the presence of mass were valuable for the differential diagnosis. Bone shell or shell-liked calcification in the rim of mass and neoplastic bone or neoplastic calcified cartilage were specific imaging signs of malignant bone tumor. Abscess-like cysts, soft tissue air, fat-fluid level and sinus tract were specific signs of osteomyelitis. (authors)

2007-04-01

348

An Investigation of the Type M Morphological Structure of IC59: A New Model for Bright Rim Clouds?  

Science.gov (United States)

We report the results from a smoothed particle hydrodynamics simulation designed to model recent observational data on the nebula and Bright Rim Cloud IC59. We further examine, in the context of radiative-driven implosion (RDI) models, the possible formation mechanisms of the morphological structure of IC59. The results of the simulation reveal the existence of a new, fourth morphological state for Bright Rim Clouds (BRCs)—which we propose to call a Type M BRC morphology. We discuss the necessary conditions for the appearance of Type M BRCs, based on analytical and numerical simulations. The simulated physical properties from our model are consistent with the available observations of IC59. We further show that the prospect of RDI triggered star formation in all Type M BRCs is not supported by the simulations.

Miao, Jingqi; Sugitani, Koji; White, Glenn J.; Nelson, Richard P.

2010-07-01

349

Trace element analysis of precious metals in minerals by time-of-flight resonance ionization mass spectrometry (TOF-RIMS)  

International Nuclear Information System (INIS)

The TOF-RIMS Mass Spectrometer, developed at AMTEL, has been successfully applied for quantitative trace element analysis of Au, Pd and Rh in sulphides, iron oxides and silicates. A series of experiments were conducted in order to test the applicability and determine the detection sensitivity of several one and two step resonant ionization schemes related to Au, Pd and Rh. The experimental data are compared with the corresponding theoretical estimates. Attained minimum detection limits are in the 8-17 ppb range with precision of ±15%. A comparative study of minerals by Dynamic SIMS and TOF-RIMS in the overlapping range of detection sensitivities for Au, Pd and Rh shows good correlation of the quantified data

2001-08-22

350

A new technique for deconvolution of data from instruments that make integral measurements, e.g. RIMS on DE-1  

Science.gov (United States)

A general method for deconvolving an unknown function from integral measurements is described and applied to data from the instrument Retarding Ion Mass Spectrometer (RIMS) aboard the spacecraft Dynamics Explorer 1 (DE-1). The principal features of the method are: (1) it uses objective criteria based upon fundamental statistical principles, i.e. Bayesian statistics; (2) it provides for insertion of prior knowledge in a non-prejudicial, explicit manner through the choice of breakpoints that determine the bicubic spline expansion functions; (3) it prevents random fluctuations from controlling the fit to the data through the use of singular value decomposition and the elimination of small singular values; and (4) it guards agianst the introduction of spurious features into the result by including a penalty function and using the principle of generalized cross validation. Illustrative examples from RIMS data for H(+) and O(+) show that the method provides enhanced accuracy and detail in deconvolving the ion phase space density.

Perez, J. D.; Liu, Chao; Lawson, Lynne; Moore, T. E.; Chappell, C. R.

1993-01-01

351

AN INVESTIGATION OF THE TYPE M MORPHOLOGICAL STRUCTURE OF IC59: A NEW MODEL FOR BRIGHT RIM CLOUDS?  

International Nuclear Information System (INIS)

We report the results from a smoothed particle hydrodynamics simulation designed to model recent observational data on the nebula and Bright Rim Cloud IC59. We further examine, in the context of radiative-driven implosion (RDI) models, the possible formation mechanisms of the morphological structure of IC59. The results of the simulation reveal the existence of a new, fourth morphological state for Bright Rim Clouds (BRCs)-which we propose to call a Type M BRC morphology. We discuss the necessary conditions for the appearance of Type M BRCs, based on analytical and numerical simulations. The simulated physical properties from our model are consistent with the available observations of IC59. We further show that the prospect of RDI triggered star formation in all Type M BRCs is not supported by the simulations.

2010-07-10

352

A novel sclerosing skeletal dysplasia with mixed sclerosing bone dysplasia, characteristic syndromic features, and clinical and radiographic evidence of male-male transmission.  

Science.gov (United States)

We report on a father and his 4-year-old son sharing a characteristic dysmorphic facial phenotype (including hyperteleroism, prominent forehead, and wide nasal bridge), macrocephaly, hearing loss, palatal clefting, developmental delay, hypotonia and bony abnormalities including marked cranial sclerosis and sclerosis of the ribs and long bones, which evolved in severity in the son between the ages of 2 and 4 years. The father's radiographs also showed prominent coarse striations, patchy metaphyseal sclerotic plaques, markedly increased bone density and cortical thickening of long bones, and significant degenerative changes in the thoracic spine. The son has an additional history of sleep apnea resulting from multi-level airway obstruction that includes adenoid hypertrophy, lingual tonsil hypertrophy, subglottic stenosis, and supra-arytenoid tissue consistent with laryngomalacia and tracheomalacia. The clinical, radiographic, and genetic findings in father and son are consistent with a sclerosing skeletal dysplasia syndrome with similarities to mixed sclerosing bone dysplasia (MSBD) including metaphyseal plaques, osteopathia striata, and cranial sclerosis (OS-CS). This family may represent one of the first descriptions of familial inheritance and evolving phenotype in MSBD. The evidence for male-male transmission would support the existence of an autosomal mechanism of inheritance for a novel form of MSBD with characteristic syndromic features. PMID:22821701

Murphy-Ryan, Maureen; Kirmani, Salman; Thompson, Dana Mara; Binkovitz, Larry A; Thomas, Kristen B; Babovic-Vuksanovic, Dusica

2012-09-01

353

On computing the instability index of a non-selfadjoint differential operator associated with coating and rimming flows  

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We study the problem of finding the instability index of certain non-selfadjoint fourth order differential operators that appear as linearizations of coating and rimming flows, where a thin layer of fluid coats a horizontal rotating cylinder. The main result reduces the computation of the instability index to a finite-dimensional space of trigonometric polynomials. The proof uses Lyapunov's method to associate the differential operator with a quadratic form, whose maximal po...

Burchard, Almut; Chugunova, Marina

2009-01-01

354

Regional fragmentation of the European Rim means that the EU must pursue policies to promote greater regional integration and cooperation.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

How can the European Union encourage trade with its immediate neighbours? Peter Havlik explores the EU’s relationship with the ‘European Rim’, an area with a population nearly as great as that of the EU. He writes that in order to increase growth by taking advantage of EU markets, Europe’s neighbours must expand their export capacities and increase their competitiveness. The EU must, in turn, adapt the current approach to its periphery by promoting intra-regional cooperation and redu...

Havlik, Peter

2013-01-01

355

Usefulness of 18F fluoride PET/CT in breast cancer patients with osteosclerotic bone metastases  

International Nuclear Information System (INIS)

Bone metastasis is an important factor for the treatment and prognosis of breast cancer patients. Whole body bone scintigraphy (WBBS) can evaluate skeletal metastases, and 18F FDG PET/CT seems to exhibit high specificity and accuracy in detecting bone metastases. However, there is a limitation of 18F FDG PET in assessing sclerotic bone metastases because some lesions may be undetectable. Recent studies showed that 18F fluoride PET/CT is more sensitive than WBBS in detecting bone metastases. This study aims to evaluate the usefulness of 18F fluoride PET/CT by comparing it with WBBS and 18F FDG PET/CT in breast cancer patients with osteosclerotic skeletal metastases. Nine breast cancer patients with suspected bone metastases (9 females; mean age ± SD, 55.6±10.0 years) underwent 99mTc MDP WBBS, 18F FDG PET/CT and 18F fluoride PET/CT. Lesion based analysis of five regions of the skeletons(skull, vertebral column, thoracic cage, pelvic bones and long bones of extremities) and patient based analysis were performed. 18F fluoride PET/CT, 18F FDG PET/CT and WBBS detected 49, 20 and 25 true metastases, respectively. Sensitivity, specificity, positive predictive value and negative predictive value of 18F fluoride PET/CT were 94.2%, 46.3%, 57.7% and 91.2%, respectively. Most true metastatic lesions of 18F fluoride PET/CT had osteosclerotic change (45/49, 91.8%), and only four lesions showed osteolytic change. Most lesions on 18F FDG PET/CT also demonstrated osteosclerotic change (17/20, 85.0%) with three osteolytic lesions. All true metastatic lesions detected on WBBS and 18F FDG PET/CT were identified on 18F fluoride PET/CT. 18F FDG PET/CT in detecting osteosclerotic metastatic lesions. 18F fluoride PET/CT might be useful in evaluating osteosclerotic metastases in breast cancer patients

2012-03-01

356

How Is Bone Cancer Diagnosed?  

Science.gov (United States)

... Topic How is bone cancer staged? How is bone cancer diagnosed? A patient’s symptoms, physical exam, and results ... and other imaging tests. Imaging tests to detect bone cancer X-rays Most bone cancers show up on ...

357

Bone resorption, metastasis, and diphosphonates  

Energy Technology Data Exchange (ETDEWEB)

This book contains 17 selections. Some of the titles are: Radiotherapy of Bone Lesions; Methodological Problems; Treatment of Bone Metastasis with Antiresorptive Drugs; Control of Bone Cancer Pain; and Chemotherapy of Bone Metastases.

Garattini, S.

1985-01-01

358

Graphite Reinforced Bone Cement.  

Science.gov (United States)

A surgical bone cement that has mechanical properties more nearly matched to those of animal bone and thermal curing characteristics which result in less traumatization of body tissues is reported. A dispersion of short high modulus graphite fibers within...

A. C. Knoell

1976-01-01

359

Fat and bone interactions.  

Science.gov (United States)

Fat and bone have a complicated relationship. Although obesity has been associated with low fracture risk, there is increasing evidence that some of the factors that are released by peripheral fat into the circulation may also have a deleterious effect on bone mass, thus, predisposing to fractures. More importantly, the local interaction between fat and bone within the bone marrow seems to play a significant role in the pathogenesis of age-related bone loss and osteoporosis. This "local interaction" occurs inside the bone marrow and is associated with the autocrine and paracrine release of fatty acids and adipokines, which affect the cells in their vicinity including the osteoblasts, reducing their function and survival. In this review, we explore the particularities of the fat and bone cell interactions within the bone marrow, their significance in the pathogenesis of osteoporosis, and the potential therapeutic applications that regulating marrow fat may have in the near future as a novel pharmacologic treatment for osteoporosis. PMID:24599601

Bermeo, Sandra; Gunaratnam, Krishanthi; Duque, Gustavo

2014-06-01

360

Smoking and Bone Health  

Science.gov (United States)

... supported by your browser. Home Bone Basics Lifestyle Smoking and Bone Health Publication available in: PDF (217 ... Overtraining Risks for Women Oral Health Partner Resources Smoking: It’s Never Too Late to Stop (NIA)

 
 
 
 
361

Unicameral (Simple) Bone Cyst  

Science.gov (United States)

... filling the cyst with materials to prevent recurrence. Curettage and bone graft. In this procedure, the cyst ... and then scraped out of the bone. After curettage, your doctor may fill the hole with a ...

362

Bone mineral density test  

Science.gov (United States)

BMD test; Bone density test; Bone densitometry; DEXA scan; DXA; Dual-energy x-ray absorptiometry; p-DEXA; Osteoporosis-BMD ... need to undress. This scan is the best test to predict your risk of fractures. Peripheral DEXA ( ...

363

Star formation in bright-rimmed clouds and cluster associated with W5 E H{\\sc ii} region  

CERN Document Server

The aim of this paper is to present the results of photometric investigations of the central cluster of the W5 E region as well as a follow-up study of the triggered star formation in and around bright-rimmed clouds (BRCs). We have carried out wide field $UBVI_c$ and deep $VI_c$ photometry of the W5 E H{\\sc ii} region. A distance of $\\sim$2.1 kpc and a mean age of $\\sim$1.3 Myr have been obtained for the central cluster. The young stellar objects (YSOs) associated with the region are identified on the basis of near-infrared and mid-infrared observations. We confirmed our earlier results that the average age of the YSOs lying on/inside the rim are younger than those lying outside the rim. The global distribution of the YSOs shows an aligned distribution from the ionising source to the BRCs. These facts indicate that a series of radiation driven implosion processes proceeded from near the central ionising source towards the periphery of the W5 E H{\\sc ii} region. We found that, in general, the age distributions...

Chauhan, Neelam; Ogura, K; Jose, J; Ojha, D K; Samal, M R; Mito, H

2011-01-01

364

A tale of two cores: Triggered massive star formation in the bright-rimmed cloud SFO 75  

CERN Document Server

Abridged: We present a detailed multi-wavelength study of the bright-rimmed cloud SFO 75, including 1.3cm and 1.2mm continuum, and 13CO and ammonia spectral line observations. The 13CO and 1.2 mm emission reveals the presence of a dense core located behind the bright rim of the cloud which is approximately coincident with that of the IRAS point source. From an analysis of the IRAS and 1.2mm fluxes we derive a dust temperature of ~30 K, a luminosity of 1.6x10^4 L\\odot and estimate the core mass to be ~570 M\\odot. The higher resolution ammonia observations resolve the 1.2mm core into two distinct cores, one directly behind the cloud's rim (Core A) and the second located slightly farther back (Core B). Comparing the morphology of Core A with that of the photon-dominated region and ionised boundary layer leaves little doubt that it is being strongly affected by the ionisation front. 2MASS and GLIMPSE archive data which reveal a small cluster of three deeply embedded high- and intermediate-mass young stellar objec...

Urquhart, J S; Morgan, L K; Pestalozzi, M R; White, G J; Muna, D N; White, Glenn J.

2007-01-01

365

The spatial-temporal evolution of aerosol optical depth and the analysis of influence factors in Bohai Rim  

Science.gov (United States)

Aerosol Optical Depth (AOD) is an important parameter of aerosol optical properties and it is an important physical parameter quantity to understanding the atmospheric environment. Bohai Rim is one of the three major urban agglomeration regions with rapidly developing economy in China. The study of AOD over this region is important to understand the environment and climate in Bohai Rim. Firstly, aerosol product data from 2000 to 2010, published by NASA, were used to analyze the temporal-spatial evolution of AOD in Bohai Rim with precision evaluation. The results showed that the spatial distribution of AOD had an obvious regional characteristic. The spatial distribution characterized that a much high value existed at urban areas and plain areas. On the contrary, the low value data existed in some mountainous regions which had higher percentages of forest coverage. The AOD values fluctuated somewhat each year in the region, from the minimum annual mean in 2003 to the maximum in 2009. Generally, the highest AOD value was in summer, followed by spring, autumn and winter. In terms of monthly variation, the value of AOD reached its peak in June and the lowest value was in December. This study analyzed the relation between AOD and some influence factors such as land use types, elevation, and distribution of urban agglomeration and so on. These results provide an important basic dataset for climate and environmental research.

Hou, Chunliang; Jiang, Hong; Wang, Xiaoyan; Pei, Huan

2014-03-01

366

Bone disease in thyrotoxicosis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Thyrotoxicosis, a clinical syndrome characterized by manifestations of excess thyroid hormone, is one of the commonly-recognised conditions of the thyroid gland. Thyrotoxicosis causes acceleration of bone remodelling and though it is one of the known risk factors for osteoporosis, the metabolic effects of thyroxine on bone are not well discussed. Studies show that thyroid hormones have effects on bone, both in vitro and in vivo. Treatment of thyrotoxicosis leads to reversal of bone loss and m...

Reddy, P. Amaresh; Harinarayan, C. V.; Sachan, Alok; Suresh, V.; Rajagopal, G.

2012-01-01

367

Calcium and bone disease  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Calcium transport and calcium signaling are of basic importance in bone cells. Bone is the major store of calcium and a key regulatory organ for calcium homeostasis. Bone, in major part, responds to calcium-dependent signals from the parathyroids and via vitamin D metabolites, although bone retains direct response to extracellular calcium if parathyroid regulation is lost. Improved understanding of calcium transporters and calcium-regulated cellular processes has resulted from analysis of gen...

Blair, Harry C.; Robinson, Lisa J.; Huang, Christopher L. -h; Sun, Li; Friedman, Peter A.; Schlesinger, Paul H.; Zaidi, Mone

2011-01-01

368

Small Animal Bone Biomechanics  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Animal models, in particular mice, offer the possibility of naturally achieving or genetically engineering a skeletal phenotype associated with disease and conducting destructive fracture tests on bone to determine the resulting change in bone’s mechanical properties. Several recent developments, including nano- and micro- indentation testing, microtensile and microcompressive testing, and bending tests on notched whole bone specimens, offer the possibility to mechanically probe small anima...

2008-01-01

369

Gracile bone dysplasias  

International Nuclear Information System (INIS)

Gracile bone dysplasias constitute a group of disorders characterised by extremely slender bones with or without fractures. We report four newborns, two of whom showed multiple fractures. Two babies had osteocraniostenosis and one had features of oligohydramnios sequence. The diagnosis in the fourth newborn, which showed thin long bones and clavicles and extremely thin, poorly ossified ribs, is uncertain. Exact diagnosis of a gracile bone dysplasia is important for genetic counselling and medico-legal reasons. (orig.)

2002-09-01

370

Eating disorders and bone.  

Science.gov (United States)

Low bone mineral density (BMD) is a frequent and often-overlooked consequence of eating disorders, in particular anorexia nervosa and eating disorders associated with the female athlete triad. The causes of low BMD are multifactorial and include low peak bone mass accrual, accelerated bone resorption, and changes in bone microarchitecture. Early diagnosis and interventions focused on nutritional rehabilitation and weight gain reduce the risk of further BMD deficits and fractures. PMID:24094471

Tomlinson, Dale; Morgan, Sarah L

2013-01-01

371

Temporal Bone Meningiomas  

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Meningiomas involving the temporal bone may originate from arachnoid cell nests present within the temporal bone (intratemporal), but more frequently originate from arachnoid cell nests of the posterior or middle cranial fossa with secondary invasion of the TB (extratemporal). In this study, we retrospectively reviewed the charts of 13 patients with meningiomas involving the temporal bone who underwent surgery. Tumors of the posterior fossa with only temporal bone hyperostosis, but without in...

Vrionis, Fotios D.; Robertson, Jon H.; Gardner, Gale; Heilman, Carl B.

1999-01-01

372

Diffusion in Bone Tissue  

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In order to prevent or modify the processes of bone degeneration the modeling and remodeling of bone tissue must be better understood. In this thesis it is assumed that the primary condition leading to bone growth is a change of the chemical environment caused by transport of matter resulting from stress driven diffusion. The change in the chemical environment may consist of changes in the concentration of different substances stimulating, for example, bone ...

Lindberg, Gustav

2013-01-01

373

Magnesium status and bone  

Energy Technology Data Exchange (ETDEWEB)

Bone abnormalities have repeatedly been reported in animals experimentally depleted of Mg and, less frequently, in conditions associated with hypermagnesemia. Effects of Mg depletion include reduced bone growth and maturation, brittleness and reduced breaking strength, increased bone density, and morphologic changes suggesting resistance to bone resorption. Which abnormalities occur or predominate apparently depends on the length and severity of Mg depletion, the age and species being depleted and other dietary constituents such as the level of Ca. A number of processes that control the formation and maintenance of bone are known to depend on Mg. As an activator of adenylate cyclase, Mg is required for secretion of parathyroid hormone (PTH) as well as end organ response to PTH. In Mg depleted individuals with hypocalcemia and reduced plasma PTH levels, Mg repletion rapidly increases plasma PTH and, more gradually, restores plasma Ca. Two additional functions of Mg probably influence bone development and structure: the role of Mg in cellular growth and development, and modulation of bone mineralization. Increasing Mg concentrations retard hydroxyapatite (HAP) formation and crystallinity. Magnesium deficient bone is more resistant to dissolution than normal bone. Bone in individuals with hypermagnesemia has been reported to show less than normal crystallinity. At present there is little well founded evidence linking bone disease in human subjects to low Mg status or chronic hypermagnesemia. Either condition could influence bone metabolism on theoretical grounds and should provide fruitful avenues for research.

Schwartz, R.

1988-01-01

374

SEPARATION OF NEWLY FORMED BONE FROM OLDER COMPACT BONE REVEALS CLEAR COMPOSITIONAL DIFFERENCES IN BONE MATRIX  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In long bone diaphyses, woven bone forms first and then transitions into a more mineralized compact bone tissue. Prior evidence suggests that the non-collagenous protein composition of woven bone may be distinct from that of more mature bone tissue, particularly with respect to a diverse group of phosphorylated, extracellular matrix proteins. To critically test this hypothesis, we developed an in situ approach to isolate newly formed bone from more mature bone within the same long bone, and c...

Midura, Ronald J.; Midura, Sharon B.; Su, Xiaowei; Gorski, Jeffrey P.

2011-01-01

375

The “Rügener Inklusionsmodell” (RIM – Effects of a school concept based on the Response to Intervention approach on the mathematics and reading achievement of German elementary school students  

Directory of Open Access Journals (Sweden)

Full Text Available Since the school year 2010/2011 on the Isle of Rügen every child starting school gets enrolled at the regular elementary school whether it has special needs or not. Framework for the structure and organization of these preventive and inclusive schools is the concept “Rügener Inklusionsmodell” (RIM which is an adaption of the US-american Response to Intervention approach (RTI. The RIM is the first large-scale implementation of a school concept in Germany which is based on RTI. This study analyses the effects of the RIM after two school years in comparison to the conventional school concept. The positive effects of RTI reported in US literature could not be replicated however findings do indicate that the RIM provides an appropriate inclusive school setting. Results for children with learning disabilities are not reliable at this point but will be presented later at the end of grade three.

Stefan Voß

2014-05-01

376

Tin in Human Bones  

Digital Repository Infrastructure Vision for European Research (DRIVER)

TIN IN HUMAN BONES. The tin content in the bones of 149 skeletons from the 1st - 5th centuries A.D., and of 11 individuals of the recent population was determined. The bone samples were carbonized and analyzed through emission spectroscopy with a.c. excitation. The tin content in bones of recent populations not exposed to extra tin supply is about one order of magnitude higher than is the case with the bones od some populations that lived at the beginning of our era. The distribut...

Jambor, Jaroslav; Smreka, Va?clav

1993-01-01

377

Method for fusing bone  

Energy Technology Data Exchange (ETDEWEB)

Method for fusing bone. The present invention is a method for joining hard tissue which includes chemically removing the mineral matrix from a thin layer of the surfaces to be joined, placing the two bones together, and heating the joint using electromagnetic radiation. The goal of the method is not to produce a full-strength weld of, for example, a cortical bone of the tibia, but rather to produce a weld of sufficient strength to hold the bone halves in registration while either external fixative devices are applied to stabilize the bone segments, or normal healing processes restore full strength to the tibia.

Mourant, Judith R. (Los Alamos, NM); Anderson, Gerhard D. (Velarde, NM); Bigio, Irving J. (Los Alamos, NM); Johnson, Tamara M. (Los Alamos, NM)

1996-01-01

378

Bone regeneration with cultured human bone grafts  

Energy Technology Data Exchange (ETDEWEB)

From 73 year old female patient, 3 ml of bone marrow was collected from the ilium. The marrow was cultured to concentrate and expand the marrow mesenchymal cells on a culture dish. The cultured cells were then subculturedeither on another culture dish or in porous areas of hydroxyapatite ceramics in the presence of dexamethasone and beta-glycerophosphate (osteo genic medium). The subculturedtissues on the dishes were analyzed by scanning electron microscopy (SEM), and subculturedtissues in the ceramics were implanted intraperitoneally into athymic nude mice. Vigorous growth of spindle-shaped cells and a marked formation of bone matrix beneath the cell layers was observed on the subculture dishes by SEM. The intraperitoneally implanted ceramics with cultured tissues revealed thick layer of lamellar bone together with active osteoblasts lining in many pore areas of the ceramics after 8 weeks. The in vitro bone formations on the culture dishes and in vivo bone formation in porous ceramics were detected. These results indicate that we can assemble an in vitro bone/ceramic construct, and due to the porous framework of the ceramic, the construct has osteogenic potential similar to that of autologous cancellous bone. A significant benefit of this method is that the construct can be made with only a small amount of aspirated marrow cells from aged patients with little host morbidity. (orig.)

Yoshikawa, T.; Nakajima, H. [Nara Medical Univ., Kashihara City (Japan). Dept. of Pathology; Nara Medical Univ., Kashihara City (Japan). Dept. of Orthopedic Surgery; Ohgushi, H.; Ueda, Y.; Takakura, Y. [Nara Medical Univ., Kashihara City (Japan). Dept. of Orthopedic Surgery; Uemura, T.; Tateishi, T. [National Inst. for Advanced Interdisciplinary Research (NAIR), Ibaraki (Japan). Tsukuba Research Center; Enomoto, Y.; Ichijima, K. [Nara Medical Univ., Kashihara City (Japan). Dept. of Pathology

2001-07-01

379

Involvement of Snf7p and Rim101p in the transcriptional regulation of TIR1 and other anaerobically upregulated genes in Saccharomyces cerevisiae.  

Science.gov (United States)

Despite the scientific and applied interest in the anaerobic metabolism of Saccharomyces cerevisiae, not all genes whose transcription is upregulated under anaerobic conditions have yet been linked to known transcription factors. Experiments with a reporter construct in which the promoter of the anaerobically upregulated TIR1 gene was fused to lacZ revealed a loss of anaerobic upregulation in an snf7Delta mutant. Anaerobic upregulation was restored by expression of a truncated allele of RIM101 that encodes for a constitutively active Rim101p. Analysis of lacZ expression in several deletion mutants confirmed that the effect of Snf7p on anaerobic upregulation of TIR1 involved Rim101p. Further studies with deletion mutants in NRG1, NRG2 and SMP1, which were previously shown to be regulated by Rim101p, could not totally elucidate the TIR1 regulation, suggesting the involvement of a more complex regulation network. However, the aerobic repression mechanism of TIR1 involved the general repressor Ssn6p-Tup1p. Transcriptome analysis in anaerobic chemostat cultures revealed that 26 additional genes exhibited an Snf7p/Rim101p-dependent anaerobic upregulation, among which, besides TIR1, are four other anaerobic genes SML1, MUC1, AAC3 and YBR300C. These results provide new evidence on the implication of the Rim101p cascade in the transcriptional regulation of anaerobic metabolism in S. cerevisiae. PMID:20402793

Snoek, Ishtar S I; Tai, Siew L; Pronk, Jack T; Yde Steensma, H; Daran, Jean-Marc

2010-06-01

380

Diabetes, Biochemical Markers of Bone Turnover, Diabetes Control, and Bone  

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Diabetes mellitus is known to have late complications including micro vascular and macro vascular disease. This review focuses on another possible area of complication regarding diabetes; bone. Diabetes may affect bone via bone structure, bone density, and biochemical markers of bone turnover. The aim of the present review is to examine in vivo from humans on biochemical markers of bone turnover in diabetics compared to non-diabetics. Furthermore, the effect of glycemic control on bone marker...

Starup-linde, Jakob

2013-01-01

 
 
 
 
381

TRIGGERED STAR FORMATION IN A BRIGHT-RIMMED CLOUD (BRC 5) OF IC 1805  

International Nuclear Information System (INIS)

We report recent optical, near-infrared (NIR), and millimeter observations which have revealed some new features of the bright-rimmed cloud BRC 5 associated with W4. With slitless spectroscopy, we detected 17 H? emission stars around the cloud; 4 are near the surface of the cloud, and 1 is toward IRAS 02252+6120. NIR photometry shows that the central H? emission star, together with one bright infrared source, has large NIR excesses and Class I spectral energy distributions. These two Class I objects are associated with the 2.9 mm continuum peaks and with a bipolar outflow, and are in between two separate, elongated C18O(J = 1-0) cores. The C18O cores and the two Class I sources are aligned along a line at position angle ?240°, somewhat less than perpendicular to the direction of UV radiation from the OB stars. Most of the detected H? emission stars, all T Tauri candidates, are located within ?3' of the cloud on the exciting star side. An estimate of the age of the stars based on a color-magnitude diagram suggests that these T Tauri candidates have ages of ?1 Myr or less, but are more evolved objects than the central young stellar objects. This age sequence suggests sequential star formation within the BRC 5 cloud. The 13CO(J = 1-0) emission shows three elongated structures, which indicates the asymmetric structure toward the UV incident axis. We present our exploratory simulation results by using a smoothed particle hydrodynamic code that suggests that the asymmetrical BRC 5 structure could possibly result from the evolution of a preexisting prolate molecular cloud subject to radiation-driven implosion (RDI). Our best-fit prolate cloud has an initial mass of ?400 M?, an axial ratio of ?1.7, and a semi-major axis of ?1.6 pc, pointing away from the ionization flux by an angle of 15°. The simulated cloud structure not only closely matches the observed asymmetric morphological structure of BRC 5, but also reveals the possibility of the development of two major cores at the head of BRC 5. For the first time, the possibility of forming two stars by an RDI mechanism in a BRC is investigated

2013-08-20

382

Computed tomographical findings of skeletal muscles in rimmed vacuole type distal myopathy  

International Nuclear Information System (INIS)

Skeletal muscle CT scans of three patients with biopsy-proven rimmed vacuole type distal myopathy(RVDM) from two unrelated families showed unique involvement pattern of the lower extremities. Parents of the patients in both families are first cousins. T.Y. is a 36-year-old woman who noticed mild difficulty in walking at 34 years of age. Now she shows waddling but still indpendent gait. Manual muscle test (MMT) revealed the following results: fair (3+/5) for hip flexion, 3 for hip extension, 3 for knee flexion, normal (5/5) for knee extension, poor (2/5) for ankle dorsi-flexion, good (4/5) for ankle plantar flexion. T.M., a 34-year-old younger sister of T.Y., started dragging her feet on gait at age 27. She could walk neither on toes nor heels. At present, she can walk only with support. MMT showed the following: 3- and trace (1/5) for hip flexion and extension, 3- and 4 for knee flexion and extension, 1 for ankle plantar- and dorsiflexion. K.W., a 33-year-old woman, began to drag her foot tips in walk and became unable to walk on toes at age 21. The leg weakness progressed into the wheelchair-ridden state at age 30. MMT gave the following results: 1 for hip flexion and extension, 2 and 4 for knee flexion and extension, zero for plantar- and dorsi-flexion. The most impressive CT findings common to these three patients are prominent contrast between the quadriceps muscles and the adductor- and hamstring-group: the former is markedly well preserved even in the most advanced patient (K.W.) while the latter are diffusely and severely affected even in the least affected patient (T.Y.). This finding well coincides with the results of MMT: the knee extensor (quadriceps muscles) fairly well keeps its strength even in the most advanced patient but the knee flexors (adductors and hamstrings) are definitely affected in the early stage of the condition. (J.P.N.)

1987-01-01

383

TRIGGERED STAR FORMATION IN A BRIGHT-RIMMED CLOUD (BRC 5) OF IC 1805  

Energy Technology Data Exchange (ETDEWEB)

We report recent optical, near-infrared (NIR), and millimeter observations which have revealed some new features of the bright-rimmed cloud BRC 5 associated with W4. With slitless spectroscopy, we detected 17 H{alpha} emission stars around the cloud; 4 are near the surface of the cloud, and 1 is toward IRAS 02252+6120. NIR photometry shows that the central H{alpha} emission star, together with one bright infrared source, has large NIR excesses and Class I spectral energy distributions. These two Class I objects are associated with the 2.9 mm continuum peaks and with a bipolar outflow, and are in between two separate, elongated C{sup 18}O(J = 1-0) cores. The C{sup 18}O cores and the two Class I sources are aligned along a line at position angle {approx}240 Degree-Sign , somewhat less than perpendicular to the direction of UV radiation from the OB stars. Most of the detected H{alpha} emission stars, all T Tauri candidates, are located within {approx}3' of the cloud on the exciting star side. An estimate of the age of the stars based on a color-magnitude diagram suggests that these T Tauri candidates have ages of {approx}1 Myr or less, but are more evolved objects than the central young stellar objects. This age sequence suggests sequential star formation within the BRC 5 cloud. The {sup 13}CO(J = 1-0) emission shows three elongated structures, which indicates the asymmetric structure toward the UV incident axis. We present our exploratory simulation results by using a smoothed particle hydrodynamic code that suggests that the asymmetrical BRC 5 structure could possibly result from the evolution of a preexisting prolate molecular cloud subject to radiation-driven implosion (RDI). Our best-fit prolate cloud has an initial mass of {approx}400 M{sub Sun }, an axial ratio of {approx}1.7, and a semi-major axis of {approx}1.6 pc, pointing away from the ionization flux by an angle of 15 Degree-Sign . The simulated cloud structure not only closely matches the observed asymmetric morphological structure of BRC 5, but also reveals the possibility of the development of two major cores at the head of BRC 5. For the first time, the possibility of forming two stars by an RDI mechanism in a BRC is investigated.

Fukuda, Naoya [Faculty of Biosphere-Geosphere Science, Okayama University of Science, 1-1 Ridai-chou, Okayama 700-0005 (Japan); Miao, Jingqi [Centre for Astrophysics and Planetary Science, School of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NR (United Kingdom); Sugitani, Koji [Graduate School of Natural Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-8501 (Japan); Kawahara, Kentaro [Faculty of Informatics, Okayama University of Science, 1-1 Ridai-chou, Okayama 700-0005 (Japan); Watanabe, Makoto [Department of Cosmosciences, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0810 (Japan); Nakano, Makoto [Faculty of Education and Welfare Science, Oita University, Oita 870-1192 (Japan); Pickles, Andrew J., E-mail: fukudany@big.ous.ac.jp [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Goleta, CA 93117 (United States)

2013-08-20

384

Triggered Star Formation in a Bright-rimmed Cloud (BRC 5) of IC 1805  

Science.gov (United States)

We report recent optical, near-infrared (NIR), and millimeter observations which have revealed some new features of the bright-rimmed cloud BRC 5 associated with W4. With slitless spectroscopy, we detected 17 H? emission stars around the cloud; 4 are near the surface of the cloud, and 1 is toward IRAS 02252+6120. NIR photometry shows that the central H? emission star, together with one bright infrared source, has large NIR excesses and Class I spectral energy distributions. These two Class I objects are associated with the 2.9 mm continuum peaks and with a bipolar outflow, and are in between two separate, elongated C18O(J = 1-0) cores. The C18O cores and the two Class I sources are aligned along a line at position angle ~240°, somewhat less than perpendicular to the direction of UV radiation from the OB stars. Most of the detected H? emission stars, all T Tauri candidates, are located within ~3' of the cloud on the exciting star side. An estimate of the age of the stars based on a color-magnitude diagram suggests that these T Tauri candidates have ages of ~1 Myr or less, but are more evolved objects than the central young stellar objects. This age sequence suggests sequential star formation within the BRC 5 cloud. The 13CO(J = 1-0) emission shows three elongated structures, which indicates the asymmetric structure toward the UV incident axis. We present our exploratory simulation results by using a smoothed particle hydrodynamic code that suggests that the asymmetrical BRC 5 structure could possibly result from the evolution of a preexisting prolate molecular cloud subject to radiation-driven implosion (RDI). Our best-fit prolate cloud has an initial mass of ~400 M ?, an axial ratio of ~1.7, and a semi-major axis of ~1.6 pc, pointing away from the ionization flux by an angle of 15°. The simulated cloud structure not only closely matches the observed asymmetric morphological structure of BRC 5, but also reveals the possibility of the development of two major cores at the head of BRC 5. For the first time, the possibility of forming two stars by an RDI mechanism in a BRC is investigated.

Fukuda, Naoya; Miao, Jingqi; Sugitani, Koji; Kawahara, Kentaro; Watanabe, Makoto; Nakano, Makoto; Pickles, Andrew J.

2013-08-01

385

Computed tomographical findings of skeletal muscles in rimmed vacuole type distal myopathy  

Energy Technology Data Exchange (ETDEWEB)

Skeletal muscle CT scans of three patients with biopsy-proven rimmed vacuole type distal myopathy(RVDM) from two unrelated families showed unique involvement pattern of the lower extremities. Parents of the patients in both families are first cousins. T.Y. is a 36-year-old woman who noticed mild difficulty in walking at 34 years of age. Now she shows waddling but still indpendent gait. Manual muscle test (MMT) revealed the following results: fair (3+/5) for hip flexion, 3 for hip extension, 3 for knee flexion, normal (5/5) for knee extension, poor (2/5) for ankle dorsi-flexion, good (4/5) for ankle plantar flexion. T.M., a 34-year-old younger sister of T.Y., started dragging her feet on gait at age 27. She could walk neither on toes nor heels. At present, she can walk only with support. MMT showed the following: 3- and trace (1/5) for hip flexion and extension, 3- and 4 for knee flexion and extension, 1 for ankle plantar- and dorsiflexion. K.W., a 33-year-old woman, began to drag her foot tips in walk and became unable to walk on toes at age 21. The leg weakness progressed into the wheelchair-ridden state at age 30. MMT gave the following results: 1 for hip flexion and extension, 2 and 4 for knee flexion and extension, zero for plantar- and dorsi-flexion. The most impressive CT findings common to these three patients are prominent contrast between the quadriceps muscles and the adductor- and hamstring-group: the former is markedly well preserved even in the most advanced patient (K.W.) while the latter are diffusely and severely affected even in the least affected patient (T.Y.). This finding well coincides with the results of MMT: the knee extensor (quadriceps muscles) fairly well keeps its strength even in the most advanced patient but the knee flexors (adductors and hamstrings) are definitely affected in the early stage of the condition. (J.P.N.).

Kunimoto, Masanari; Kawai, Mitsuru; Goto, Jun; Nakano, Imaharu

1987-03-01

386

Human prostatic acid phosphatase directly stimulates collagen synthesis and alkaline phosphatase content of isolated bone cells  

International Nuclear Information System (INIS)

Human prostatic acid phosphatase (hPAP) directly enhances the differentiated characteristics of isolated bone cells in vitro. This enzyme, when added to cell cultures for 24 h in vitro stimulates collagen synthesis and the production of alkaline phosphatase. The effects are dose dependent, with statistically significant effects occurring from 0.1-100 nM hPAP. Concentrations higher than 100 nM do not evoke greater effects. The maximal effect of hPAP occurs between 12 and 24 h of exposure. The cells stimulated to the greatest degree are osteoprogenitor cells and osteoblasts. Fibroblasts isolated from the same tissue show a lesser sensitivity to hPAP. hPAP has no detectable effect on cell proliferation, as measured by radiolabeled thymidine incorporation or total DNA synthesis. None of the observations reported in this work can be attributed to contaminating proteins in the hPAP preparation. hPAP was radiolabeled with 125I and was used for affinity binding and cross-linking studies. Scatchard analysis of specific binding indicated the presence of 1.0 X 10(5) high affinity binding sites/cell, with a Kd of 6.5 nM. Cross-linking studies demonstrated the presence of one 320-kDa binding complex. The pH profile and kinetic determinations of Km and maximum velocity for hPAP were similar to those previously reported, except for the finding of positive cooperativity of the substrate with the enzyme under the conditions of our assay. We believe that the direct stimulation of bone-forming cells by hPAP may contribute to the sclerotic nature of skeletal bone around sites of neoplastic prostatic metastases and that the effect of the enzyme is probably mediated by a plasma membrane receptor

1991-01-01

387

Bone Conduction Head Sensitivity Mapping: Bone Vibrator.  

Science.gov (United States)

The military is interested in ways to incorporate radio communication in a multi-tasking environment. Bone conduction (BC) radio communication is an attractive means to communicate because it offers the ability to transmit and receive radio communication ...

M. McBride T. R. Letowski P. K. Tran

2005-01-01

388

Mandibular Bone Crafts with Surface Decalcified Bone.  

Science.gov (United States)

Experimental studies on dogs are reported, comparing autologous marrow grafts with surface decalcified allogenic grafts and surface decalcified allogenic grafts with autologous marrow fragments. Findings indicate that mandibular bone grafts composed of a ...

D. B. Osbon G. E. Lilly J. C. Jones P. B. Hackett

1972-01-01

389

Bone health in adolescence  

Directory of Open Access Journals (Sweden)

Full Text Available The skeleton undergoes rapid change with respect to growth, modeling and remodeling processes in adolescence. Consequently, the effects of factors that affect bone health positively or negatively can be greater. Between 40% and 60% of, peak bone mass which serves as the bone bank for life, is accrued during adolescence. Lifetime risk of osteoporosis and fracture may be increased if optimal peak bone mass cannot be reached.Accrual of peak bone mass is affected by unmodifiable intrinsic factors and less important extrinsic factors. Higher body mass index and body fat and lower dietary calcium intake increase fracture risk in healthy adolescents. Bone mass was found to be 5% to 10% lower in adolescents with fracture than their peers. Adequate nutrition in amount and composition and life style factors are important for skeletal health. While diets rich in saturated fats and refined sugars and lower in protein may be detrimental to bone health, optimal quantities of polyunsaturated fatty acids and complex carbohydrates may be beneficial to bone health. Dietary calcium and vitamin D are key factors in promoting bone health and preventing bone loss. Phosphorus and magnesium as well as other elements and especially vitamin C and K have been shown to play important roles in bone health. While weight bearing regular exercise and a healthy bodyweight are beneficial to bone health, alcohol consumption and smoking contribute to poor bone health. Adolescence may serve as a period of opportunity for reduction of the incidence of osteoporosis in adulthood through implication of effective intervention strategies. (Turk Arch Ped 2011; 46 Suppl: 54-8

Oya

2011-03-01

390

Distinct focal lesions of the femoral head: imaging features suggesting an atypical and minimal form of bone necrosis  

Energy Technology Data Exchange (ETDEWEB)

Heading AbstractObjective. To document the imaging findings observed in patients with an unusual pattern of abnormality of the femoral head, most likely representing osteonecrosis.Design and patients. The imaging findings in 11 patients (10 men, 1 woman; age range 32-55 years) with a distinct lesion of the femoral head were reviewed with particular attention to the morphologic appearance, location, and extent of the lesion(s) in the proximal femur.Results. The 16 lesions identified in these patients extended to the subchondral area. Articular collapse was not evident in any hip. Radiography and CT showed areas of mixed bone sclerosis and osteolysis surrounded by sclerotic margins. On MR imaging, the signal intensity characteristics of the osseous lesion(s) were most commonly similar to those of fluid. Histopathologic findings, available in two hips, were typical of osteonecrosis. There was evidence of correlation of the site of the lesion with the known general distribution and anastomoses of arteries supplying the femoral head.Conclusion. A distinct, focal lesion of the femoral head is believed to represent an atypical form of bone necrosis. Its restriction to a small portion of the femoral head may relate to localized vascular anatomy. Recognition of the quite characteristic imaging findings can prevent misdiagnosis and may have implications for the prediction of the natural course of the disease. (orig.)

Theodorou, Daphne J. [Department of Radiology, School of Medicine, University of California, San Diego Medical Center, San Diego, California (United States); Department of Radiology, Veterans Administration Medical Center, San Diego, California (United States); Department of Radiology, Veterans Administration Medical Center, 3350 La Jolla Village Drive, San Diego, California 92161 (United States); Theodorou, Stavroula J.; Resnick, Donald [Department of Radiology, School of Medicine, University of California, San Diego Medical Center, San Diego, California (United States); Department of Radiology, Veterans Administration Medical Center, San Diego, California (United States); Haghighi, Parviz [Department of Pathology, Veterans Administration Medical Center, San Diego, California (United States)