F-127-PEI co-delivering docetaxel and TFPI-2 plasmid for nasopharyngeal cancer therapy

International Nuclear Information System (INIS)

Liu, Tao; Zhang, Xinyu; Ke, Bo; Wang, Yigang; Wu, Xidong; Jiang, Gang; Wu, Ting; Nie, Guohui

2016-01-01

The co-delivery of drug and gene has become the primary strategy in cancer therapy. However, to construct one safe co-delivering system with higher drug loading and gene transfection efficiency for cancer therapy is still challenging. Herein, a novel degradable nanocarriers were synthesized and characterized in this study, which was composed of polyethylenimine (PEI)-linked PEO–PPO–PEO (Pluronic F127), called F127-PEI. Then the nanocarrier was used for hydrophobic docetaxel (DOC) and functional gene (TFPI-2 plasmid) co-delivery to treat nasopharyngeal cancer (NPC). The results indicated that F127-PEI nanocarriers had higher DOC loading amount and possessed good gene delivery effect in vitro. For co-delivery analysis, the obtained F127-PEI/DOC/TFPI-2 complexes could induce a more significant apoptosis than DOC or TFPI-2 alone, and decreased invasive capacity of NPC HNE-1 cells more obviously. Moreover, the F127-PEI copolymer exhibited better blood compatibility and lower cytotoxicity compared to PEI-25k by the hemolysis and MTT assays, which suggests a promising potential for NPC therapy. - Highlights: • F127-PEI was synthesized and used for drug and gene co-delivery. • F127-PEI showed good delivery ability to docetaxel and TFPI-2 plasmid. • The co-loaded complexes showed synergistic effect to nasopharyngeal carcinoma. • F127-PEI showed better blood safety and lower cytotoxicity compared to PEI-25k

Optimization of conditions for gene delivery system based on PEI

Directory of Open Access Journals (Sweden)

Roya Cheraghi

2017-01-01

Full Text Available Objective(s: PEI based nanoparticle (NP due to dual capabilities of proton sponge and DNA binding is known as powerful tool for nucleic acid delivery to cells. However, serious cytotoxicity and complicated conditions, which govern NPs properties and its interactions with cells practically, hindered achievement to high transfection efficiency. Here, we have tried to optimize the properties of PEI/ firefly luciferase plasmid complexes and cellular condition to improve transfection efficiency. Materials and Methods: For this purpose, firefly luciferase, as a robust gene reporter, was complexed with PEI to prepare NPs with different size and charge. The physicochemical properties of nanoparticles were evaluated using agarose gel retardation and dynamic light scattering.  MCF7 and BT474 cells at different confluency were also transfected with prepared nanoparticles at various concentrations for short and long times. Results: The branched PEI can instantaneously bind to DNA and form cationic NPs. The results demonstrated the production of nanoparticles with size about 100-500 nm dependent on N/P ratio. Moreover, increase of nanoparticles concentration on the cell surface drastically improved the transfection rate, so at a concentration of 30 ng/ìl, the highest transfection efficiency was achieved. On the other side, at confluency between 40-60%, the maximum efficiency was obtained. The result demonstrated that N/P ratio of 12 could establish an optimized ratio between transfection efficiency and cytotoxicity of PEI/plasmid nanoparticles. The increase of NPs N/P ratio led to significant cytotoxicity. Conclusion: Obtained results verified the optimum conditions for PEI based gene delivery in different cell lines.

Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent

Directory of Open Access Journals (Sweden)

Yancong Zhang

2015-01-01

Full Text Available Novel method for synthesis of superparamagnetic iron oxide nanoparticles (SPIONs coated with polyethylenimine (PEI and modified with poly(ethylene glycol methyl ether (MPEG, MPEG-PEI-SPIONs, was developed. PEI-SPIONs were successfully prepared in aqueous system via photochemistry, and their surface was modified with poly(ethylene glycol methyl ether (MPEG. The so-obtained MPEG-PEI-SPIONs had a uniform hydrodynamic particle size of 34 nm. The successful coating of MPEG-PEI on the SPIONs was ascertained from FT-IR analysis, and the PEI and MPEG fractions in MPEG-PEI-SPIONs were calculated to account for 31% and 12%, respectively. Magnetic measurement revealed that the saturated magnetization of MPEG-PEI-SPIONs reached 46 emu/g and the nanoparticles showed the characteristic of being superparamagnetic. The stability experiment revealed that the MPEG-PEI modification improved the nanoparticles stability greatly. T2 relaxation measurements showed that MPEG-PEI-SPIONs show similar R2 value to the PEI-SPIONs. The T2-weighted magnetic resonance imaging (MRI of MPEG-PEI-SPIONs showed that the magnetic resonance signal was enhanced significantly with increasing nanoparticle concentration in water. These results indicated that the MPEG-PEI-SPIONs had great potential for application in MRI.

The synthesis of desired functional groups on PEI microgel particles for biomedical and environmental applications

Science.gov (United States)

Sahiner, Nurettin; Demirci, Sahin; Sahiner, Mehtap; Al-Lohedan, Hamad

2015-11-01

Polyethyleneimine (PEI) microgels were synthesized by micro emulsion polymerization technique and converted to positively charged forms by chemical treatments with various modifying agents with different functional groups, such as 2-bromoethanol (-OH), 4-bromobutyronitrile (-CN), 2-bromoethylamine hydrobromide (-NH2), and glycidol (-OH). The functionalization of PEI microgels was confirmed by FT-IR, TGA and zeta potential measurements. Furthermore, a second modification of the modified PEI microgels was induced on 4-bromo butyronitrile-modified PEI microgels (PEI-CN) by amidoximation, to generate new functional groups on the modified PEI microgels. The PEI and modified PEI microgels were also tested for their antimicrobial effects against various bacteria such as Bacillus subtilis ATCC 6633, Escherichia coli ATCC 8739 and Staphylococcus aureus ATCC 25323. Moreover, the PEI-based particles were used for removal of organic dyes such as methyl orange (MO) and congo red (CR). The absorption capacity of PEI-based microgels increased with modification from 101.8 mg/g to 218.8 mg/g with 2-bromoethylamine, 216.2 m/g with 1-bromoethanol, and 224.5 mg/g with 4-bromobutyronitrile for MO. The increase in absorption for CR dyes was from 347.3 mg/g to 390.4 mg/g with 1-bromoethanol, 399.6 mg/g with glycidol, and 349.9 mg/g with 4-bromobutyronitrile.

Fang Dongmeijeva filozofija ustvarjalnega kozmosa

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Jana S. ROŠKER

2014-12-01

Full Text Available Fang Dongmei (1899–1977 is one of the main representatives of the second generation of Modern Confucianism, though he never explicitly claimed to be only a Confucian, but stressed being––in his soul––also a Daoist and Buddhist. The theoretical contribution of this philosopher (who is still rather neglected in the West to the development of modern Chinese philosophy is doubtlessly worth detailed research. The present article mainly deals with the analysis and interpretation of the ontological and epistemological aspects of his philosophy. It focuses upon the introduction of the following concepts, central to his philosophy: comprehensive harmony, Confucian moral self, creative creativity, unity of facts and values, as well as reason and intuition.

Minxin Pei, China's Crony Capitalism: The Dynamics of Regime Decay

DEFF Research Database (Denmark)

Brødsgaard, Kjeld Erik

2017-01-01

Book review of: Minxin Pei, China's Crony Capitalism: The Dynamics of Regime Decay. Cambridge, Mass.: Harvard University Press, 2016. 365 pp., including references and index. ISBN 9780674737297.......Book review of: Minxin Pei, China's Crony Capitalism: The Dynamics of Regime Decay. Cambridge, Mass.: Harvard University Press, 2016. 365 pp., including references and index. ISBN 9780674737297....

Effect of Songyu Anshen Fang on expression of hypothalamic GABA ...

African Journals Online (AJOL)

Purpose: To investigate the effects of the Chinese compound, Songyu Anshen Fang (SYF) on levels of GABA and GABA(B) receptor proteins in insomniac rats induced by para-chlorophenylalanine (PCPA). Methods: All rats were randomly separated into either a control group, insomnia group, or a SYF group (at a dose of ...

Calibration of Linked Hydrodynamic and Water Quality Model for Santa Margarita Lagoon

Science.gov (United States)

2016-07-01

was used to drive the transport and water quality kinetics for the simulation of 2007–2009. The sand berm, which controlled the opening/closure of...TECHNICAL REPORT 3015 July 2016 Calibration of Linked Hydrodynamic and Water Quality Model for Santa Margarita Lagoon Final Report Pei...Linked Hydrodynamic and Water Quality Model for Santa Margarita Lagoon Final Report Pei-Fang Wang Chuck Katz Ripan Barua SSC Pacific James

PEI detoxification of pretreated spruce for high solids ethanol fermentation

International Nuclear Information System (INIS)

Cannella, David; Sveding, Per Viktor; Jørgensen, Henning

2014-01-01

Highlights: • High solids (30% dry matter) pretreatment, enzymatic hydrolysis and fermentation. • Horizontal rotary reactor for hydrolysis and fermentation. • In situ hydrolysates detoxification using inhibitors adsorbing PEI polymer. • 50% of inhibitors recovered as by-product, recyclability of PEI polymer up to 5 times. • 76% of maximum theoretical ethanol was fermented at final concentration of 51 g/kg. - Abstract: Performing the bioethanol production process at high solids loading is a requirement for economic feasibility at industrial scale. So far this has successfully been achieved using wheat straw and other agricultural residues at 30% of water insoluble solids (WIS), but for softwood species (i.e. spruce) this has been difficult to reach. The main reason behind this difference is the higher recalcitrance of woody substrates which require harsher pretreatment conditions, thus generating higher amounts of inhibitory compounds, ultimately lowering fermentation performances. In this work we studied ethanol production from spruce performing the whole process, from pretreatment to hydrolysis and fermentation, at 30% dry matter (equivalent to ∼20% WIS). Hydrolysis and fermentation was performed in a horizontal free fall mixing reactor enabling efficient mixing at high solids loadings. In batch simultaneous saccharification and fermentation (SSF), up to 76% cellulose to ethanol conversion was achieved resulting in a concentration of 51 g/kg of ethanol. Key to obtaining this high ethanol yield at these conditions was the use of a detoxification technology based on applying a soluble polyelectrolyte polymer (polyethylenimine, PEI) to absorb inhibitory compounds in the material. On average 50% removal and recovery of the main inhibitors (HMF, furfural, acetic acid and formic acid) was achieved dosing 1.5% w/w of soluble PEI. The use of PEI was compatible with operating the process at high solids loadings and enabled fermentation of hydrolysates, which

Synthesis of polyetherimide / halloysite nanotubes (PEI/HNTs) based nanocomposite membrane towards hydrogen storage

Science.gov (United States)

Muthu, R. Naresh; Rajashabala, S.; Kannan, R.

2018-04-01

Even though hydrogen is considered as green and clean energy sources of future, the blooming of hydrogen economy mainly relies on the development of safe and efficient hydrogen storage medium. The present work is aimed at the synthesis and characterization of polyetherimide/acid treated halloysite nanotubes (PEI/A-HNTs) nanocomposite membranes for solid state hydrogen storage medium, where phase inversion technique was adopted for the synthesis of nanocomposite membrane. The synthesized PEI/A-HNTs nanocomposite membranes were characterized by XRD, FTIR, SEM, EDX, CHNS elemental analysis and TGA. Hydrogenation studies were performed using a Sievert's-like hydrogenation setup. The important conclusions arrived from the present work are the PEI/A-HNTs nanocomposite membranes have better performance with a maximum hydrogen storage capacity of 3.6 wt% at 100 °C than pristine PEI. The adsorbed hydrogen possesses the average binding energy of 0.31 eV which lies in the recommended range of US- DOE 2020 targets. Hence it is expected that the PEI/A-HNTs nanocomposite membranes may have bright extent in the scenario of hydrogen fuel cell applications.

miRNA oligonucleotide and sponge for miRNA-21 inhibition mediated by PEI-PLL in breast cancer therapy.

Science.gov (United States)

Gao, Shiqian; Tian, Huayu; Guo, Ye; Li, Yuce; Guo, Zhaopei; Zhu, Xiaojuan; Chen, Xuesi

2015-10-01

MicroRNA-21 (miR-21) inhibition is a promising biological strategy for breast cancer therapy. However its application is limited by the lack of efficient miRNA inhibitor delivery systems. As a cationic polymer transfection material for nucleic acids, the poly (l-lysine)-modified polyethylenimine (PEI-PLL) copolymer combines the high transfection efficiency of polyethylenimine (PEI) and the good biodegradability of polyllysine (PLL). In this work, PEI-PLL was successfully synthesized and confirmed to transfect plasmid and oligonucleotide more effectively than PEI in MCF-7 cells (human breast cancer cells). In this regard, two kinds of miR-21 inhibitors, miR-21 sponge plasmid DNA (Sponge) and anti-miR-21 oligonucleotide (AMO), were transported into MCF-7 cells by PEI-PLL respectively. The miR-21 expression and the cellular physiology were determined post transfection. Compared with the negative control, PEI-PLL/Sponge or PEI-PLL/AMO groups exhibited lower miR-21 expression and cell viability. The anti-tumor mechanism of PEI-PLL/miR-21 inhibitors was further studied by cell cycle and western blot analyses. The results indicated that the miR-21 inhibition could induce the cell cycle arrest in G1 phase, upregulate the expression of Programmed Cell Death Protein 4 (PDCD4) and thus active the caspase-3 apoptosis pathway. Interestingly, the PEI-PLL/Sponge and PEI-PLL/AMO also sensitized the MCF-7 cells to anti-tumor drugs, doxorubicin (DOX) and cisplatin (CDDP). These results demonstrated that PEI-PLL/Sponge and PEI-PLL/AMO complexes would be two novel and promising gene delivery systems for breast cancer gene therapy based on miR-21 inhibition. This work was a combination of the high transfection efficiency of polyethylenimine (PEI), the good biodegradability of polyllysine (PLL) and the breast cancer-killing effect of miR-21 inhibitors. The poly (l-lysine)-modified polyethylenimine (PEI-PLL) copolymer was employed as the vector of miR-21 sponge plasmid DNA (Sponge) or

Efficient production of retroviruses using PLGA/bPEI-DNA nanoparticles and application for reprogramming somatic cells.

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Eun Jin Seo

Full Text Available Reprogramming of somatic cells to pluripotent cells requires the introduction of factors driving fate switches. Viral delivery has been the most efficient method for generation of induced pluripotent stem cells. Transfection, which precedes virus production, is a commonly-used process for delivery of nucleic acids into cells. The aim of this study is to evaluate the efficiency of PLGA/ bPEI nanoparticles in transfection and virus production. Using a modified method of producing PLGA nanoparticles, PLGA/bPEI-DNA nanoparticles were examined for transfection efficiency and virus production yield in comparison with PLGA-DNA, bPEI-DNA nanoparticles or liposome-DNA complexes. After testing various ratios of PLGA, bPEI, and DNA, the ratio of 6:3:1 (PLGA:bPEI:DNA, w/w/w was determined to be optimal, with acceptable cellular toxicity. PLGA/bPEI-DNA (6:3:1 nanoparticles showed superior transfection efficiency, especially in multiple gene transfection, and viral yield when compared with liposome-DNA complexes. The culture supernatants of HEK293FT cells transfected with PLGA/bPEI-DNA of viral constructs containing reprogramming factors (Oct4, Sox2, Klf4, or c-Myc successfully and more efficiently generated induced pluripotent stem cell colonies from mouse embryonic fibroblasts. These results strongly suggest that PLGA/bPEI-DNA nanoparticles can provide significant advantages in studying the effect of multiple factor delivery such as in reprogramming or direct conversion of cell fate.

[Textual research on Chen Ye and his Jia cang jing yan fang (Family-preserved Empirical Recipes) of the Song Dynasty].

Science.gov (United States)

Zhang, Xuedan; Zhang, Ruqing; Chen, Dexing

2014-01-01

Chen Ye, an official of the Southern Song Dynasty, also known as Chen Rihua as his styled name, was born in Changle, Fuzhou in the reign of Shaoxing, and died during the reign of Duanping. He had been consecutively in the positions of Jiang shi lang (Court Gentleman for Ceremonial Service), Zhi zhou (Prefect) of Lingding, the Ti xing (Judicial Commissioner) of Guangdong, the Zong ling (Overseer-general) of Sichuan, Shan ding (Reviser), Shu lin and other positions in Tongzhou, Yuanzhou. His works included 1 volume of Gu ling xian sheng nian pu (Mr. Guling's Chronological Biography), 1 volume of Tan xie (On Humor), 1 volume of Shi hua (Poetry), 8 volumes of Jin yuan li shu (Jin Yuan's Smart Technique), 3 volumes of Yi jian zhi lei bian (Classified Compilation of Yijian's Annals), (Zeng guang) Suo sui lu (Augmented Records of Trivial Matters), 5 volumes of Jia cang jing yan fang (Family-preserved Empirical Recipes). He also compiled the 8-volume Yin jiang zhi (Yinjiang's Annals), published the 2-volume Jia cang ji yao fang (Collected Essential Recipes from Family Preservation), and other proses and poetry. Jia cang jing yan fang was a formulary compiled by Chen Ye, which was lost. Altogether 74 of its recipes were cited in Fu ren da quan liang fang (Complete Effective Prescriptions for Women's Diseases), Shou qin yang lao shu (A Book for Pursuing Seniors' Longevity and Healthcare), Pu ji fang (Prescriptions for Universal Relief) and Yong le da dian (Yongle Encyclopedia).

Temperature, salinity, sigma_t, pressure measurement collected using CTD from an unknown platform in the Min Fang Bay from 1984 to 1985 (NODC Accession 0048830)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Southern Ocean data - Min Fang Bay , temperature and salinity measurements collected using CTD from unknown platform in the Min Fang Bay from 1984 to 1985

Reinforced PEI/PVdF Multicore-Shell Structure Composite Membranes by Phase Prediction on a Ternary Solution

Directory of Open Access Journals (Sweden)

Jihye Chae

2018-04-01

Full Text Available To construct a polyetherimide (PEI-reinforced polyvinylidene fluoride (PVdF composite membrane with multicore-shell structure, a ternary solution was prepared and electrospun by single-nozzle electrospinning. A theoretical prediction was made for the feasibility of complete distinction of two phases. The diameters of the membrane fibers and the PEI multi-core fibrils varied with the PEI ratio and the spinning time, respectively. The tensile strength and modulus were improved to 48 MPa and 1.5 GPa, respectively. The shrinkage of the membrane was only 6.6% at 180 °C, at which temperature the commercial PE separator melted down. The reinforcement in mechanical and thermal properties is associated with multiple PEI nanofibrils oriented along the fiber axis. Indeed, the unique morphology of self-assembled multicore-shell fibers plays an important role in their properties. All in all, PEI/PVdF membranes are appropriate for a lithium-ion battery application due to their high mechanical strength, excellent thermal stability, and controllable textural properties.

A novel adsorbent TEMPO-mediated oxidized cellulose nanofibrils modified with PEI: Preparation, characterization, and application for Cu(II) removal

Energy Technology Data Exchange (ETDEWEB)

Zhang, Nan; Zang, Guo-Long; Shi, Chen; Yu, Han-Qing; Sheng, Guo-Ping, E-mail: gpsheng@ustc.edu.cn

2016-10-05

Highlights: • A cellulose nanofibril based adsorbent with abundant carboxyl/amino was prepared. • After modification by PEI, the Cu adsorption capacity of nanofibril increased. • TOCN-PEI has good Cu(II) removal ability and its maximum capacity was 52.32 mg g{sup −1}. • Results show Cu adsorption on TOCN-PEI is an exothermic and enthalpy-driven process. • Sorption-desorption tests reveal that TOCN-PEI has good stability for Cu removal. - Abstract: This study describes the preparation of a novel adsorbent based on cellulose nanofibrils by first TEMPO mediated oxidation and then PEI grafting (TOCN-PEI) for heavy metal removal. FTIR results demonstrated the successful introduction of the adsorption functional groups (carboxyl and amino groups), and the elemental analysis and acid base titration were used to quantify the contents of these introduced groups. The kinetics curve suited the pseudo-second-order model better and the equilibrium data well fitted the Langmuir model, with the maximum Cu(II) uptake of 52.32 mg g{sup −1}. Kinetic study showed that the PEI grafting increased the initial adsorption rate of the TOCN-PEI compared with the adsorbents without PEI. Thermodynamic study was carried out through isothermal titration calorimetry (ITC) measurement and the binding reaction was found to be exothermic and driven by enthalpy change. The adsorption process by TOCN-PEI was pH dependent, and decreasing pH would lead to desorption of Cu(II) ions, thus make the reuse of the absorbent more convenient through adsorption-desorption cycles.

Studies on preparing and adsorption property of grafting terpolymer microbeads of PEI-GMA/AM/MBA for bilirubin.

Science.gov (United States)

Gao, Baojiao; Lei, Haibo; Jiang, Liding; Zhu, Yong

2007-06-15

Crosslinking copolymer microbeads with a diameter range of 100-150 microm were synthesized by suspension copolymerization of glycidyl methacrylate (GMA), acrylamide (AM) and N,N'-methylene bisacrylamide (MBA). Subsequently, polyethyleneimine (PEI) was grafted on the surfaces of the terpolymer microbeads GMA/AM/MBA via the ring-opening reaction of the epoxy groups, and the grafting microbeads PEI-GMA/AM/MBA were prepared. In this paper, the adsorption property of the grafting microbeads for bilirubin was mainly investigated, and the effects of various factors, such as pH value, ionic strength and grafting degree of PEI on the surface of grafting microbeads and the adsorption capacity of the grafting microbeads for bilirubin were examined. The batch adsorption experiment results show that by right of the action of grafted polyamine macromolecules PEI, the grafting microbeads PEI-GMA/AM/MBA have quite strong adsorption ability for bilirubin; the isotherm adsorption conforms to Freundlich equation. The pH value of the medium affects the adsorption capacity greatly, As in the nearly neutral solutions with pH 6, the grafting microbeads have the strongest adsorption ability for bilirubin, whereas in acidic and basic solutions their adsorption ability is weak. The ionic strength hardly affects the adsorption ability of the grafting microbeads. The grafting degree of PEI on the surfaces of the grafting microbeads also has a great effect on the adsorption capacity, and higher the grafting degree of PEI on the surface of the microbead PEI-GMA/AM/MBA, the stronger is the adsorption ability of the microbeads.

FANS-3D Users Guide (ESTEP Project ER 201031)

Science.gov (United States)

2016-08-01

TECHNICAL DOCUMENT 3293 August 2016 FANS -3D User’s Guide (ESTEP Project ER-201031) Pei-Fang Wang SSC Pacific Hamn-Ching...1.1 THEORY AND NUMERICAL ALGORITHM OF FANS CODE ............................................. 1 2. FANS -3D SOFTWARE DOCUMENTATION AND EXECUTION...5 3. FANS -3D CODE PARALLELIZATION

Amiloidose renal em cão Shar-Pei: Relato de Caso Renal amyloidosis in a Shar-Pei dog: A case report

Directory of Open Access Journals (Sweden)

J.L. Reis Jr.

2001-08-01

Full Text Available O presente relato descreve os achados clínicos e anatomopatológicos de um caso de amiloidose renal em um cão macho de nove anos da raça Shar-Pei. O animal apresentava quadro clínico de esporotricose e de insuficiência renal e exames positivos para erlichiose e leishmaniose. No dia anterior ao óbito, o cão apresentou apatia, desidratação e anúria. À necropsia foram observados inúmeros pontos milimétricos esbranquiçados localizados no córtex renal e hepatização do lobo diafragmático esquerdo. O achado histológico mais importante foi deposição de material eosinofílico, amorfo e acelular localizado nos tufos glomerulares que se corou positivamente pelo vermelho congo (amilóide. Observaram-se nefrite supurada multifocal, espessamento da cápsula de Bowman e broncopneumonia supurada crônica, com fibrose intensa. A origem da amiloidose, no presente caso, poderia ser hereditária, assemelhando-se à amiloidose familiar descrita em cães da raça Shar-Pei, ou ser devida à inflamação supurada crônica e/ou leishmaniose.The clinical and pathological findings of a case of renal amyloidosis in a nine-year-old male Shar-Pei dog were described. Clinically, there were signs of sporotrichosis and renal insufficiency, besides being positive to leishmaniasis and ehrlichiosis. On the day before death, the animal became apathetic, dehydrated and anuric. On gross examination, there were several whitish millimetric spots seen widespread in both renal cortices and consolidation of the left diaphragmatic pulmonary lobe. The most important microscopic finding was a deposition of amorphous acellular material on the glomerular tufts which stained positively by congo red stain. Other changes were multifocal suppurative nephritis, thickening of the Bowman capsule and chronic suppurative bronchopneumonia. The origin of the amyloidosis in this case could be hereditary, being similar to familiar amyloidosis described in Shar-Pei breed, or due to

Development of swellable local implants of a polyethyleneimine-poly(vinyl pyrrolidone) (PEI-PVP) hydrogel as a socket filler.

Science.gov (United States)

Chang, Ching-Wen; Ho, Hsiu-O; Lo, Yi-June; Lee, Sheng-Yang; Yang, You-Ren; Sheu, Ming-Thau

2012-01-01

In this study, hydrogels composed of polyethyleneimine (PEI) and poly(vinyl pyrrolidone) K90 (PVP) cross-linked with various concentrations (0, 0.125, 0.25 and 0.5%) of glutaraldehyde were evaluated as a hydrogel filler for the local delivery of lidocaine after tooth extraction. The drug-release kinetics, swellability, cytotoxicity and wound healing after tooth extraction of these non-cross-linked and cross-linked PEI-PVP hydrogels were examined in male beagles and compared to values using Spongostan(®). Results demonstrated that the extent of cross-linking influenced the swelling of the resulting hydrogel, but the drug-release rates were similar. No significant changes were observed in gingival fibroblasts in contact with the PEI- PVP hydrogels or Spongostan(®). In the in vivo study, PEI-PVP hydrogels showed good retention in the socket for 2 days and showed comparable wound-healing rates within 2 weeks with those of Spongostan(®). In conclusion, PEI-PVP hydrogels are suitable for use as socket-dressing materials, and the release of local anaesthesia from PEI-PVP hydrogels can be sustained for a desirable period of time to prevent pain after a tooth extraction.

Ergonomic Analysis of Garment Industry using Posture Evaluation Index (PEI) in Virtual Environment

OpenAIRE

Erlinda Muslim; Boy Nurtjahyo; Romadhani Ardi

2011-01-01

This research tried to study, in a virtual environment, the ergonomics of four divisions in garment industry: cutting division, sewing division, button division, and finishing division. Variables that influence the working conditions in each division are different; depend on the real situations that happened. The purpose is to assess the real working conditions based on ergonomics  study  using Posture Evaluation Index (PEI). PEI integrates  the scores of  low back analysi...

The Possible "Proton Sponge " Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH

DEFF Research Database (Denmark)

Søndergaard, Rikke Vicki; Mattebjerg, Maria Ahlm; Henriksen, Jonas Rosager

2013-01-01

is still elusive. The "proton sponge " hypothesis remains the most generally accepted mechanism, although it is heavily debated. This hypothesis is associated with the large buffering capacity of PEI and other polycations, which has been interpreted to cause an increase in lysosomal pH even though...... no conclusive proof has been provided. In the present study, we have used a nanoparticle pH sensor that was developed for pH measurements in the endosomal/lysosomal pathway. We have carried out quantitative measurements of lysosomal pH as a function of PEI content and correlate the results to the "proton sponge...... " hypothesis. Our measurements show that PEI does not induce change in lysosomal pH as previously suggested and quantification of PEI concentrations in lysosomes makes it uncertain that the "proton sponge " effect is the dominant mechanism of polyplex escape.Molecular Therapy (2012); doi:10.1038/mt.2012.185....

Effective mRNA Inhibition in PANC-1 Cells in Vitro Mediated via an mPEG-SeSe-PEI Delivery System.

Science.gov (United States)

Zhang, Yuefeng; Yang, Bin; Liu, Yajie; Qin, Wenjie; Li, Chao; Wang, Lantian; Zheng, Wen; Wu, Yulian

2016-05-01

RNA interference (RNAi)-mediated gene therapy is a promising approach to cure various diseases. However, developing an effective, safe, specific RNAi delivery system remains a major challenge. In this study, a novel redox-responsive polyetherimide (PEI)-based nanovector, mPEG-SeSe-PEI, was developed and its efficacy evaluated. We prepared three mPEG-SeSe-PEI vector candidates for small interfering glyceraldehyde-3-phosphate dehydrogenase (siGADPH) and determined their physiochemical properties and transfection efficiency using flow cytometry and PEG11.6-SeSe-PEI polymer. We investigated the silencing efficacy of GADPH mRNA expression in PANC-1 cells and observed that PEG11.6-SeSe-PEI/siGADPH (N/P ratio=10) polyplexes possessed the appropriate size and zeta-potential and exhibited excellent in vitro gene silencing effects with the least cytotoxicity in PANC-1 cells. In conclusion, we present PEG11.6-SeSe-PEI as a potential therapeutic gene delivery system for small interfering RNA (siRNA).

75 FR 80798 - Notice of Intent To Prepare a Programmatic Environmental Impact Statement (PEIS) for Land...

Science.gov (United States)

2010-12-23

... DEPARTMENT OF DEFENSE Department of the Army Notice of Intent To Prepare a Programmatic Environmental Impact Statement (PEIS) for Land Acquisition, South Texas Training Center (STTC), in McMullen... media sources. To ensure scoping comments are fully considered in the preparation of the PEIS, comments...

Enhanced corrosion protective PANI-PAA/PEI multilayer composite coatings for 316SS by spin coating technique

Energy Technology Data Exchange (ETDEWEB)

Syed, Junaid Ali; Lu, Hongbin; Tang, Shaochun; Meng, Xiangkang, E-mail: mengxk@nju.edu.cn

2015-01-15

Highlights: • PANI-PAA/PEI multilayers with controllable thickness were fabricated by spin assembly. • PAA matrix results in the homogeneous dispersion of PANI in the composite coatings. • Spin coating combined with heating assures the linear increase in thickness with n. • The corrosion protection property of PANI-PAA/PEI coatings were optimized at n = 20. • Enhanced protection owing to multilayer structure that lengthens the diffusion pathway of ions. - Abstract: In the present study, polyaniline-polyacrylic acid/polyethyleneimine (PANI-PAA/PEI) composite coatings with a multilayer structure for corrosion protection of 316 stainless steels (316SS) were prepared by an alternate deposition. Spin coating combined with heating assists removal of residual water that result in a linear increase in thickness with layer number (n). The combination of PANI-PAA composite with PEI and their multilayer structure provides a synergistic enhancement of corrosion resistance properties as determined by electrochemical measurements in 3.5% NaCl solution. Importantly, the PANI-PAA/PEI coating with an optimized layer number of n = 20 shows improved corrosion protection. The superior performance was attributed to the formation of an interfacial oxide layer as well as the multilayer structure that extend the diffusion pathway of corrosive ions.

‘Cultural encounters: Western scholarship and Fang statuary from Equatorial Africa’ [Inaugural address, delivered on the acceptance of an extraordinary professorship at Tilburg University, Netherlands, in 2011

Directory of Open Access Journals (Sweden)

Wilfried van Damme

2014-12-01

Full Text Available In this inaugural address, delivered on the acceptance of an extraordinary professorship at Tilburg University, Netherlands, in 2011, Wilfried van Damme examines three approaches that have been characteristically applied within the Western anthropology of art during the last half century. Illustrating these approaches with reference to the study of Fang statuary from equatorial Africa, he discusses a stylistic approach, focusing on anatomical details and proportions of Fang anthropomorphic sculptures; a culturalist approach, highlighting the local meaning and values these sculptures express; and a postcolonial approach, dealing with the Western appropriation and commodification of Fang statues.

Hyperbranched–dendrimer architectural copolymer gene delivery using hyperbranched PEI conjugated to poly(propyleneimine) dendrimers: synthesis, characterization, and evaluation of transfection efficiency

Energy Technology Data Exchange (ETDEWEB)

Alavi, Seyyed Jamal [Ferdowsi University of Mashhad, Department of Chemistry, Faculty of Science (Iran, Islamic Republic of); Gholami, Leila [Mashhad University of Medical Sciences, Department of Modern Sciences and Technologies, School of Medicine (Iran, Islamic Republic of); Askarian, Saeedeh [Mashhad University of Medical Sciences, Department of Medical Biotechnology, School of Medicine (Iran, Islamic Republic of); Darroudi, Majid [Mashhad University of Medical Sciences, Nuclear Medicine Research Center (Iran, Islamic Republic of); Massoudi, Abdolhossein [University of Payam noor, Department of Chemistry (Iran, Islamic Republic of); Rezaee, Mehdi; Kazemi Oskuee, Reza, E-mail: Oskueekr@mums.ac.ir [Mashhad University of Medical Sciences, Department of Medical Biotechnology, School of Medicine (Iran, Islamic Republic of)

2017-02-15

The applications of dendrimer-based vectors seem to be promising in non-viral gene delivery because of their potential for addressing the problems with viral vectors. In this study, generation 3 poly(propyleneimine) (G3-PPI) dendrimers with 1, 4-diaminobutane as a core initiator was synthesized using a divergent growth approach. To increase the hydrophobicity and reduce toxicity, 10% of primary amines of G3-PPI dendrimers were replaced with bromoalkylcarboxylates with different chain lengths (6-bromohexanoic and 10-bromodecanoic). Then, to retain the overall buffering capacity and enhance transfection, the alkylcarboxylate–PPIs were conjugated to 10 kDa branched polyethylenimine (PEI). The results showed that the modified PPI was able to form complexes with the diameter of less than 60 nm with net-positive surface charge around 20 mV. No significant toxicity was observed in modified PPIs; however, the hexanoate conjugated PPI–PEI (PPI-HEX-10% PEI) and the decanoate conjugated PPI–PEI (PPI-DEC-10%-PEI) showed the best transfection efficiency in murine neuroblastoma (Neuro-2a) cell line, even PPI-HEX-10%-PEI showed transfection efficiency equal to standard PEI 25 kDa with reduced toxicity. This study suggested a new series of hyperbranched (PEI)–dendrimer (PPI) architectural copolymers as non-viral gene delivery vectors with high transfection efficiency and low toxicity.

Hyperbranched-dendrimer architectural copolymer gene delivery using hyperbranched PEI conjugated to poly(propyleneimine) dendrimers: synthesis, characterization, and evaluation of transfection efficiency

Science.gov (United States)

Alavi, Seyyed Jamal; Gholami, Leila; Askarian, Saeedeh; Darroudi, Majid; Massoudi, Abdolhossein; Rezaee, Mehdi; Kazemi Oskuee, Reza

2017-02-01

The applications of dendrimer-based vectors seem to be promising in non-viral gene delivery because of their potential for addressing the problems with viral vectors. In this study, generation 3 poly(propyleneimine) (G3-PPI) dendrimers with 1, 4-diaminobutane as a core initiator was synthesized using a divergent growth approach. To increase the hydrophobicity and reduce toxicity, 10% of primary amines of G3-PPI dendrimers were replaced with bromoalkylcarboxylates with different chain lengths (6-bromohexanoic and 10-bromodecanoic). Then, to retain the overall buffering capacity and enhance transfection, the alkylcarboxylate-PPIs were conjugated to 10 kDa branched polyethylenimine (PEI). The results showed that the modified PPI was able to form complexes with the diameter of less than 60 nm with net-positive surface charge around 20 mV. No significant toxicity was observed in modified PPIs; however, the hexanoate conjugated PPI-PEI (PPI-HEX-10% PEI) and the decanoate conjugated PPI-PEI (PPI-DEC-10%-PEI) showed the best transfection efficiency in murine neuroblastoma (Neuro-2a) cell line, even PPI-HEX-10%-PEI showed transfection efficiency equal to standard PEI 25 kDa with reduced toxicity. This study suggested a new series of hyperbranched (PEI)-dendrimer (PPI) architectural copolymers as non-viral gene delivery vectors with high transfection efficiency and low toxicity.

[PHEMA/PEI]–Cu(II) based immobilized metal affinity chromatography cryogels: Application on the separation of IgG from human plasma

Energy Technology Data Exchange (ETDEWEB)

Bakhshpour, Monireh; Derazshamshir, Ali; Bereli, Nilay [Department of Chemistry, Biochemistry Division, Hacettepe University, Ankara (Turkey); Elkak, Assem [Laboratory of “Valorisation des Ressources Naturelles et Produits de Santé (VRNPS)”, Doctoral School of Sciences and Technology, Lebanese University, Rafic Hariri University Campus, Hadath (Lebanon); Denizli, Adil, E-mail: denizli@hacettepe.edu [Department of Chemistry, Biochemistry Division, Hacettepe University, Ankara (Turkey)

2016-04-01

The immobilized metal-affinity chromatography (IMAC) has gained significant interest as a widespread separation and purification tool for therapeutic proteins, nucleic acids and other biological molecules. The enormous potential of IMAC for proteins with natural surface exposed-histidine residues and for recombinant proteins with histidine clusters. Cryogels as monolithic materials have recently been proposed as promising chromatographic adsorbents for the separation of biomolecules in downstream processing. In the present study, IMAC cryogels have been synthesized and utilized for the adsorption and separation of immunoglobulin G (IgG) from IgG solution and whole human plasma. For this purpose, Cu(II)-ions were coupled to poly(hydroxyethyl methacrylate) PHEMA using poly(ethylene imine) (PEI) as the chelating ligand. In this study the cryogels formation optimized by the varied proportion of PEI from 1% to 15% along with different amounts of Cu (II) as chelating metal. The prepared cryogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The [PHEMA/PEI]–Cu(II) cryogels were assayed for their capability to bind the human IgG from aqueous solutions. The IMAC cryogels were found to have high affinity toward human IgG. The adsorption of human IgG was investigated onto the PHEMA/PEI cryogels with (10% PEI) and the concentration of Cu (II) varied as 10, 50, 100 and 150 mg/L. The separation of human IgG was achieved in one purification step at pH 7.4. The maximum adsorption capacity was observed at the [PHEMA/PEI]–Cu(II) (10% PEI) with 72.28 mg/g of human IgG. The purification efficiency and human IgG purity were investigated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). - Highlights: • Cu(II)-ions were coupled to PHEMA using PEI as the chelating ligand. • Cu(II) chelated [PHEMA/PEI] cryogels for IgG separation were produced. • Maximum IgG adsorption capacity

[PHEMA/PEI]–Cu(II) based immobilized metal affinity chromatography cryogels: Application on the separation of IgG from human plasma

International Nuclear Information System (INIS)

Bakhshpour, Monireh; Derazshamshir, Ali; Bereli, Nilay; Elkak, Assem; Denizli, Adil

2016-01-01

The immobilized metal-affinity chromatography (IMAC) has gained significant interest as a widespread separation and purification tool for therapeutic proteins, nucleic acids and other biological molecules. The enormous potential of IMAC for proteins with natural surface exposed-histidine residues and for recombinant proteins with histidine clusters. Cryogels as monolithic materials have recently been proposed as promising chromatographic adsorbents for the separation of biomolecules in downstream processing. In the present study, IMAC cryogels have been synthesized and utilized for the adsorption and separation of immunoglobulin G (IgG) from IgG solution and whole human plasma. For this purpose, Cu(II)-ions were coupled to poly(hydroxyethyl methacrylate) PHEMA using poly(ethylene imine) (PEI) as the chelating ligand. In this study the cryogels formation optimized by the varied proportion of PEI from 1% to 15% along with different amounts of Cu (II) as chelating metal. The prepared cryogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The [PHEMA/PEI]–Cu(II) cryogels were assayed for their capability to bind the human IgG from aqueous solutions. The IMAC cryogels were found to have high affinity toward human IgG. The adsorption of human IgG was investigated onto the PHEMA/PEI cryogels with (10% PEI) and the concentration of Cu (II) varied as 10, 50, 100 and 150 mg/L. The separation of human IgG was achieved in one purification step at pH 7.4. The maximum adsorption capacity was observed at the [PHEMA/PEI]–Cu(II) (10% PEI) with 72.28 mg/g of human IgG. The purification efficiency and human IgG purity were investigated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). - Highlights: • Cu(II)-ions were coupled to PHEMA using PEI as the chelating ligand. • Cu(II) chelated [PHEMA/PEI] cryogels for IgG separation were produced. • Maximum IgG adsorption capacity

Simple synthesis of nitrogen-rich polymer network and its further amination with PEI for CO2 adsorption

Science.gov (United States)

Yin, Fengqin; Zhuang, Linzhou; Luo, Xianyong; Chen, Shuixia

2018-03-01

The nitrogen-rich polymer network (MF/PAM) was synthesized through interpenetration between the molecular chains of melamine-formaldehyde resin(MF) and polyacrylamide (PAM), to which the polyethylene imine (PEI) was grafted to obtain solid amine adsorbent (MF/PAM-g-PEI). Compared with MF, the swelling capacity of MF/PAM was greatly enhanced, it could swell rapidly and directly in water. Although the interpenetration of PAM into MF may reduce the porosity of MF/PAM, the CO2 capture capacity of the solid amine adsorbents (MF/PAM-g-PEI) could still reach 2.8 mmol/g at 273 K. The adsorbents also exhibited promising adsorption kinetics and regeneration performances. The kinetics observation showed that the Avrami model could better descript the CO2 adsorption process compared with the pseudo-first-order model and pseudo-second-order model. Meanwhile, the Avrami kinetic orders (na) range from 1.21 to 1.56, displaying that the both physisorption and chemisorption exist in the adsorption process and the PEI have successfully grafted onto the polymer network, which also can be confirmed by the adsorption activation energy value. After 18 adsorption-desorption recycles, the MF/PAM-g-PEI could preserve its initial capacity without any decrease. Our work provides a new method to achieve promising solid amine adsorbents with higher adsorption capacity and better regeneration performance.

Probing the effect of polymer molecular weight on penetration into the wood cell wall using polyethylenimine (PEI) as a model compound.

Science.gov (United States)

Dorvel, Brian; Boopalachandran, Praveenkumar; Chen, Ida; Bowling, Andrew; Williams, Kerry; King, Steve

2018-05-01

Decking is one of the largest applications for the treated wood market. The most challenging property to obtain for treated wood is dimensional stability, which can be achieved, in part, by cell wall bulking, cell wall polymer crosslinking and removal of hygroscopic components in the cell wall. A commonly accepted key requirement is for the actives to infuse through the cell wall, which has a microporosity of ∼5-13 nm. Equally as challenging is being able to measure and quantify the cell wall penetration. Branched polyethylenimine (PEI) was studied as a model polymer for penetration due to its water solubility, polarity, variable molecular weight ranges, and ability to form a chelation complex with preservative metals to treat lumbers. Two different molecular weight polyethylenimines (PEI), one with a weight average molecular weight (Mw) equal to 800 Da and the other 750 000 Da, were investigated for penetration by microscopy and spectroscopy techniques. Analytical methods were developed to both create smooth interfaces and for relative quantitation and visualisation of PEI penetration into the wood. The results showed both PEI with Mw of 800 Da and PEI with Mw of 750 000 Da coated the lumens in high density. However, only the PEI with Mw of 800 appeared to penetrate the cell walls in sufficient levels. Literature has shown the hydrodynamic radii of PEI 750 000 is near 29 nm, whereas a smaller PEI at 25 K showed 4.5 nm. Most importantly the results, based on methods developed, show how molecular weight and tertiary structure of the polymer can affect its penetration, with the microporosity of the wood being the main barrier. © 2017 The Authors Journal of Microscopy © 2017 Royal Microscopical Society.

Characteristics of the anti-dementia drug system of Zisu Fang preparations based on pharmacokinetic and pharmacodynamic analysis

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Jianye Quan

2017-04-01

Conclusions: Based on the PK and PD correlation analysis, baicalin, rosmarinic acid, salvianolic acid B, matrine, and tanshinone IIA are the main active ingredients of Zisu Fang preparations with regard to its anti-dementia effects, and represent the basic characteristics of drug system: natures, synergy, and affinity.

Synthesis, and Characterization, and Evaluation of Cellular Effects of the FOL-PEG-g-PEI-GAL Nanoparticles as a Potential Non-Viral Vector for Gene Delivery

International Nuclear Information System (INIS)

Ghiamkazemi, S.; Amanzadeh, A.; Dinarvand, R.; Rafiee-Tehrani, M.; Amini, M.; Ghiamkazemi, S.; Dinarvand, R.; Rafiee-Tehrani, M.; Ghiamkazemi, S.; Rafiee-Tehrani, M.; Amanzadeh, A.; Rafiee-Tehrani, M.

2010-01-01

In this manuscript, we synthesized the potential non viral vector for gene delivery with proper transfection efficiency and low cytotoxicity. Polyethylenimine (PEI) is a well-known cationic polymer which has high positive surface charge for condensing plasmid DNA. However; it is highly cytotoxic in many cell lines because of the high surface charge, non-biodegradability and non-biocompatibility. To enhance PEI biodegradability, the graft copolymer PEG-g-PEI was synthesized. To target cancer liver cells, two targeting ligands folic acid and galactose (lactobionic acid) which are over expressed on human hepatocyte carcinoma were attached to graft copolymer and FOL-PEG-g-PEI-GAL copolymer was synthesized. Composition of this grafted copolymer was characterized using 1H-NMR and FTIR spectra. The molecular weight and zeta potential of this copolymer was compared to PEI. The particle size and zeta potential of FOL-PEG-g-PEI-GAL/DNA complexes at various N/P ratio were measured using dynamic light scattering (DLS). Cytotoxicity of the copolymer was also studied in cultured HepG2 human hepatoblastoma cell line. The FOL-PEG-g-PEI-GAL/DNA complexes at various N/P ratios exhibited no cytotoxicity in HepG2 cell line compared to PEI 25K as a control. The novel copolymer showed enhanced biodegradability in physiological conditions in compared with PEI and targeted cultured HepG2 cells. More importantly, significant transfection efficiency was exhibited in cancer liver cells. Together, our results showed that FOL-PEG-g-PEI-GAL nanoparticles could be considered as a useful non-viral vector for targeted gene delivery.

Le corpus lexicographique dans les langues à tradition orale: le cas du dialecte fang-mekè*

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Nzang-Bié Yolande

2011-10-01

Full Text Available

Résumé: Les corpus sont à la base de la plupart des recherches en linguistique et particulièrementlexicographique. La compilation d'un corpus est une activité spécialisée dont dépend lerésultat de la recherche en question. Le sujet de cet article est la compilation du corpus lexicographiquedans les langues à tradition orale, et exige une démarche différente de celle ayant unelongue tradition écrite. De ce fait, ces dernières disposent d'une importante documentationpouvant servir comme base pour de nombreux sujets de recherche. L'auteur propose commeapproche une analyse qui permettrait de mieux rendre compte des spécificités lexicales etsémantiques des langues à tradition orale.Par le truchement de la production orale libre, l'auteur base ses hypothèses de recherche surune expérience en dialecte fang-mekè, une variante linguistique localisée au Gabon. Les résultatspermettent de mettre l'accent sur deux données essentielles du processus de compilation dans leslangues à tradition orale: les informateurs et la représentativité du corpus. Cette dernière, qui doits'exprimer à travers des champs lexicaux diversifiés mais également équilibrés, permettrait d'élaborerdes dictionnaires dans lesquels les locuteurs, qui en sont les premiers utilisateurs, doivent sereconnaître.

Mots-clés: CORPUS, LEXICOGRAPHIE, LANGUES À TRADITION ORALE, LANGUES ÀTRADITION ÉCRITE, INFORMATEURS, EXHAUSTIVITÉ, REPRÉSENTATIVITÉ, CHAMPSLEXICAUX, ORALITÉ, ÉCRITURE, MÉTHODE, DIALECTE FANG-MEKÈ, CORPUS ÉQUILIBRÉ.

Abstract: The Lexicographic Corpus in Languages with an Oral Tradition: The Case of the Dialect Fang-Mek?. Corpora form the basis of most linguistic and especially lexicographic research. The compilation of a corpus is a specialised activity on which depends the result of the research to be undertaken. The subject of this article is the compilation of a lexicographic corpus in languages with an oral tradition

Stabilization of Candida antarctica Lipase B (CALB Immobilized on Octyl Agarose by Treatment with Polyethyleneimine (PEI

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Sara Peirce

2016-06-01

Full Text Available Lipase B from Candida antarctica (CALB was immobilized on octyl agarose (OC and physically modified with polyethyleneimine (PEI in order to confer a strong ion exchange character to the enzyme and thus enable the immobilization of other enzymes on its surface. The enzyme activity was fully maintained during the coating and the thermal stability was marginally improved. The enzyme release from the support by incubation in the non-ionic detergent Triton X-100 was more difficult after the PEI-coating, suggesting that some intermolecular physical crosslinking had occurred, making this desorption more difficult. Thermal stability was marginally improved, but the stability of the OCCALB-PEI was significantly better than that of OCCALB during inactivation in mixtures of aqueous buffer and organic cosolvents. SDS-PAGE analysis of the inactivated biocatalyst showed the OCCALB released some enzyme to the medium during inactivation, and this was partially prevented by coating with PEI. This effect was obtained without preventing the possibility of reuse of the support by incubation in 2% ionic detergents. That way, this modified CALB not only has a strong anion exchange nature, while maintaining the activity, but it also shows improved stability under diverse reaction conditions without affecting the reversibility of the immobilization.

Effect of expanded graphite and PEI-co-Silicon Rubber on the thermo mechanical, morphological as well as rheological properties of in situ composites based on poly (ether imide) and liquid crystalline polymer

Energy Technology Data Exchange (ETDEWEB)

Hatui, Goutam, E-mail: hatui.goutam@gmail.com; Malas, Asish, E-mail: malasasish@gmail.com; Bhattacharya, Pallab; Dhibar, Saptarshi, E-mail: saptaaus2007@gmail.com; Kundu, Mrinal Kanti, E-mail: kanti.mrinal19@gmail.com; Kumar Das, Chapal, E-mail: chapal12@yahoo.co.in

2015-01-15

Highlights: • PEI/LCP/ PEI-co-Silicon Rubber/EG and PEI/LCP/MWCNT nano composites are prepared by melt blending method. • The dispersions of acid modified expanded graphite were improved in presence of PEI-co-Silicon Rubber. • Thermal stability was found to be highest for PLGC composite. • Storage modulus and Young’s modulus showed an upward trend with incorporation of only EG and EG in presence of PEI-co-Silicon Rubber. • Among the nano composites PLGC has highest viscosity. - Abstract: Nanocomposites of polyether imide (PEI) and liquid crystalline polymer (LCP) with either MWCNT, Expanded Graphite (EG) or in combination of both EG and PEI-co-Silicon Rubber were prepared by melt blending process. The compatibility between the polymeric phases (PEI and LCP) was observed to be increased by the addition of PEI-co-Silicon Rubber while the only MWCNT added system (PLC) resulted in smaller LCP droplets. A continuous morphology was produced in presence of both PEI-co-Silicon Rubber and EG both added system (PLGR). This was due to the compatibilizing effect of PEI-co-Silicon Rubber. FTIR analysis revealed interaction between PEI and LCP in presence of PEI-co-Silicon Rubber. Remarkable increment of storage modulus was observed with the addition of EG and PEI-co-Silicon Rubber. Transmission Electron Microscope (TEM) analysis showed better dispersion of multiple graphene layers of EG in presence of PEI-co-Silicon Rubber compatibilized system. Tensile and Young’s modulus both were highest for EG/ PEI-co-Silicon Rubber added system. This is due to flexible compatibilizing effect of PEI-co-Silicon Rubber which delayed the detachment of LCP domain from the PEI matrix and thus detains the fracture.

Effect of expanded graphite and PEI-co-Silicon Rubber on the thermo mechanical, morphological as well as rheological properties of in situ composites based on poly (ether imide) and liquid crystalline polymer

International Nuclear Information System (INIS)

Hatui, Goutam; Malas, Asish; Bhattacharya, Pallab; Dhibar, Saptarshi; Kundu, Mrinal Kanti; Kumar Das, Chapal

2015-01-01

Highlights: • PEI/LCP/ PEI-co-Silicon Rubber/EG and PEI/LCP/MWCNT nano composites are prepared by melt blending method. • The dispersions of acid modified expanded graphite were improved in presence of PEI-co-Silicon Rubber. • Thermal stability was found to be highest for PLGC composite. • Storage modulus and Young’s modulus showed an upward trend with incorporation of only EG and EG in presence of PEI-co-Silicon Rubber. • Among the nano composites PLGC has highest viscosity. - Abstract: Nanocomposites of polyether imide (PEI) and liquid crystalline polymer (LCP) with either MWCNT, Expanded Graphite (EG) or in combination of both EG and PEI-co-Silicon Rubber were prepared by melt blending process. The compatibility between the polymeric phases (PEI and LCP) was observed to be increased by the addition of PEI-co-Silicon Rubber while the only MWCNT added system (PLC) resulted in smaller LCP droplets. A continuous morphology was produced in presence of both PEI-co-Silicon Rubber and EG both added system (PLGR). This was due to the compatibilizing effect of PEI-co-Silicon Rubber. FTIR analysis revealed interaction between PEI and LCP in presence of PEI-co-Silicon Rubber. Remarkable increment of storage modulus was observed with the addition of EG and PEI-co-Silicon Rubber. Transmission Electron Microscope (TEM) analysis showed better dispersion of multiple graphene layers of EG in presence of PEI-co-Silicon Rubber compatibilized system. Tensile and Young’s modulus both were highest for EG/ PEI-co-Silicon Rubber added system. This is due to flexible compatibilizing effect of PEI-co-Silicon Rubber which delayed the detachment of LCP domain from the PEI matrix and thus detains the fracture

[On academic thought and clinical application of LI Yan-Fang's middle-warmer energy method].

Science.gov (United States)

Li, Li-Jun

2010-10-01

The present paper introduces LI Yan-Fang's middle-warmer energy method from acupoint selection, needling methods, treatment principle and his clinical experiences in treatment of stroke and insomnia etc. The acupuncture prescription of this method consist of Shangwan (CV 13), Zhongwan (CV 12), Jianli (CV 11), Xiawan (CV 10), Shuifen (CV 9), Huangshu (KI 16) and Qihai (CV 6) etc as the main acupoints combined with strict manipulation and depth of needling to treat clinical diseases.

Linear and Branched PEIs (Polyethylenimines and Their Property Space

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Claudiu N. Lungu

2016-04-01

Full Text Available A chemical property space defines the adaptability of a molecule to changing conditions and its interaction with other molecular systems determining a pharmacological response. Within a congeneric molecular series (compounds with the same derivatization algorithm and thus the same brute formula the chemical properties vary in a monotonic manner, i.e., congeneric compounds share the same chemical property space. The chemical property space is a key component in molecular design, where some building blocks are functionalized, i.e., derivatized, and eventually self-assembled in more complex systems, such as enzyme-ligand systems, of which (physico-chemical properties/bioactivity may be predicted by QSPR/QSAR (quantitative structure-property/activity relationship studies. The system structure is determined by the binding type (temporal/permanent; electrostatic/covalent and is reflected in its local electronic (and/or magnetic properties. Such nano-systems play the role of molecular devices, important in nano-medicine. In the present article, the behavior of polyethylenimine (PEI macromolecules (linear LPEI and branched BPEI, respectively with respect to the glucose oxidase enzyme GOx is described in terms of their (interacting energy, geometry and topology, in an attempt to find the best shape and size of PEIs to be useful for a chosen (nanochemistry purpose.

Design of PEI-conjugated bio-reducible polymer for efficient gene delivery.

Science.gov (United States)

Nam, Joung-Pyo; Kim, Soyoung; Kim, Sung Wan

2018-07-10

The poly(cystaminebis(acrylamide)-diaminohexane) (poly(CBA-DAH)) was designed previously as a bio-reducible efficient gene delivery carrier. However, the high weight ratio required to form the polyplexes between poly(CBA-DAH) with pDNA is still a problem that needs to be addressed. To solve this problem and increase the transfection efficiency, poly(ethylenimine) (PEI, 1.8 kDa) was conjugated to poly(CBA-DAH) via disulfide bond. The PEI conjugated poly(CBA-DAH) (PCDP) can bind with pDNA at a very low weight ratio of 0.5 and above, like PEI 25 kDa, and form the polyplexes with nano-size (102-128 nm) and positive surface charge (27-34 mV). PCDP and PCDP polyplexes had negligible cytotoxicity and indicated similar or better cellular uptake than the comparison groups such as PEI 25 kDa and Lipofectamine® polyplexes. To confirm the transfection efficiency, the plasmid DNA (pDNA) encoded with the luciferase reporter gene (gWiz-Luc) and green fluorescent protein reporter gene (GFP) were used and treated with PCDP into the A549, Huh-7, and Mia PaCa-2 cells. PCDP/pDNA polyplexes showed highest transfection efficiency in all tested cell lines. In the luciferase assay, PCDP polyplexes showed 10.2 times higher gene transfection efficiency than Lipofectamine® polyplexes in mimic in vivo conditions (30% FBS, A549 cells). The VEGF siRNA expressing plasmid (pshVEGF), which is constructed as a therapeutic gene by our previous work, was delivered by PCDP into the cancer cells. The VEGF gene expression of PCDP/pshVEGF polyplexes was dramatically lower than control and the VEGF gene silencing efficiencies of PCDP/pshVEGF (w/w; 10/1) polyplexes were 54% (A549 cells), 77% (Huh-7 cells), and 66% (Mia PaCa-2 cells). In addition, PCDP/pshVEGF had reduced cell viability rates of about 31% (A549 cells), 39% (Huh-7 cells), and 42% (Mia PaCa-2 cells) and showed better results than all comparison groups. In the transfection efficiency and VEGF silencing assay, PCDP polyplexes showed

Haemocytic leukemia in Prince Edward Island (PEI) soft shell clam (Mya arenaria): Spatial distribution in agriculturally impacted estuaries

International Nuclear Information System (INIS)

Muttray, Annette; Reinisch, Carol; Miller, Jason; Ernst, William; Gillis, Patricia; Losier, Melanie; Sherry, James

2012-01-01

Intensive farming of potatoes in Prince Edward Island (PEI) relies on the repeated and widespread application of fertilizers and pesticides. In PEI the main potato farming areas are in close proximity and drain directly to estuaries. Runoff from high agricultural activity watersheds could impact benthic organism health in the depositional zone of downstream estuaries. The estuarine filter feeder Mya arenaria (soft-shell clam) could be particularly vulnerable to both particle-adsorbed and water soluble contaminants. M. arenaria is susceptible to haemocytic leukemia. In May 2009, we established that heavily proliferated leukemia (HPL) prevalence was generally higher in PEI estuaries located downstream of high intensity potato farming (Dunk and Wilmot estuaries) watersheds than in estuaries downstream of lower intensity areas. Using Mab-1E10 based immunocytochemistry we observed that leukemic haemocytes from the Dunk and Wilmot estuaries were 1E10 negative whereas those from the Ox/Sheep estuary (low potato farming intensity) were 1E10 positive. The expression of genes in the p53 tumour suppressor pathway enabled us to differentiate groups of leukemic and normal M. arenaria, validating our diagnoses. In October 2009, we confirmed that HPL prevalence was elevated in the Dunk and Wilmot estuaries compared to reference (Souris River). Moreover, leukemia prevalence declined with distance from the river mouths along transects through the Dunk and Wilmot estuaries. The pesticides ß-endosulfan and α-endosulfan were detected in surface sediments from the Dunk and Wilmot estuaries, but not in sediments from either the Souris River or several other lower intensity potato farming watersheds. Our study provides evidence of an association between intensity of potato farming and prevalence of clam leukemia at downstream estuaries in PEI. - Highlights: ► We examined leukemia prevalence in PEI clams Mya arenaria. ► Prevalence was generally higher downstream of high intensity

Polio Eradication Initiative (PEI) contribution in strengthening public health laboratories systems in the African region.

Science.gov (United States)

Gumede, Nicksy; Coulibaly, Sheick Oumar; Yahaya, Ali Ahmed; Ndihokubwayo, Jean-Bosco; Nsubuga, Peter; Okeibunor, Joseph; Dosseh, Annick; Salla, Mbaye; Mihigo, Richard; Mkanda, Pascal; Byabamazima, Charles

2016-10-10

The laboratory has always played a very critical role in diagnosis of the diseases. The success of any disease programme is based on a functional laboratory network. Health laboratory services are an integral component of the health system. Efficiency and effectiveness of both clinical and public health functions including surveillance, diagnosis, prevention, treatment, research and health promotion are influenced by reliable laboratory services. The establishment of the African Regional polio laboratory for the Polio Eradication Initiative (PEI) has contributed in supporting countries in their efforts to strengthen laboratory capacity. On the eve of the closing of the program, we have shown through this article, examples of this contribution in two countries of the African region: Côte d'Ivoire and the Democratic Republic of Congo. Descriptive studies were carried out in Côte d'Ivoire (RCI) and Democratic Republic of Congo (DRC) from October to December 2014. Questionnaires and self-administered and in-depth interviews and group discussions as well as records and observation were used to collect information during laboratory visits and assessments. The PEI financial support allows to maintain the majority of the 14 (DRC) and 12 (RCI) staff involved in the polio laboratory as full or in part time members. Through laboratory technical staff training supported by the PEI, skills and knowledge were gained to reinforce laboratories capacity and performance in quality laboratory functioning, processes and techniques such as cell culture. In the same way, infrastructure was improved and equipment provided. General laboratory quality standards, including the entire laboratory key elements was improved through the PEI accreditation process. The Polio Eradication Initiative (PEI) is a good example of contribution in strengthening public health laboratories systems in the African region. It has established strong Polio Laboratory network that contributed to the

"Glimpses of the Duanwu Festival" by Fang Xun (1736-1799) : commemorative painting or private souvenir ?

OpenAIRE

Kerlan-Stephens , Anne

2001-01-01

International audience; Fang Xun (1736 or 1737-1799) was a painter from the Hangzhou area who is now known essentially as the author of a treatise on painting, although he enjoyed during his lifetime local artistic fame. This paper details his relationship with a network of friends and clients belonging to the local gentry through the analysis of a painting he realized around 1780, describing a gathering at the estate of his main patron, Jin Deyu (1750-1800).

Haemocytic leukemia in Prince Edward Island (PEI) soft shell clam (Mya arenaria): Spatial distribution in agriculturally impacted estuaries

Energy Technology Data Exchange (ETDEWEB)

Muttray, Annette, E-mail: amuttray@rescan.com [Environment Canada, Water Science and Technology Directorate, 867 Lakeshore Road, Burlington, ON, Canada L7R 4A6 (Canada); Reinisch, Carol, E-mail: creinisch@mbl.edu [Visiting Scientist Environment Canada, Water Science and Technology Directorate, 867 Lakeshore Road, Burlington, ON, Canada L7R 4A6 (Canada); Miller, Jason, E-mail: j.miller@ec.gc.ca [Environment Canada, Water Science and Technology Directorate, 867 Lakeshore Road, Burlington, ON, Canada L7R 4A6 (Canada); Ernst, William, E-mail: bill.ernst@ec.gc.ca [Environment Canada, Water Science and Technology Directorate, 45 Alderney Drive, Dartmouth, NS, Canada B2Y 2N6 (Canada); Gillis, Patricia, E-mail: patty.gillis@ec.gc.ca [Environment Canada, Water Science and Technology Directorate, 867 Lakeshore Road, Burlington, ON, Canada L7R 4A6 (Canada); Losier, Melanie, E-mail: melanie.losier@ec.gc.ca [Environment Canada, Atlantic Laboratory for Environmental Testing, Environmental Science Centre, P.O. Box 23005 Moncton, NB, Canada E1A 6S8 (Canada); Sherry, James, E-mail: jim.sherry@ec.gc.ca [Environment Canada, Water Science and Technology Directorate, 867 Lakeshore Road, Burlington, ON, Canada L7R 4A6 (Canada)

2012-05-01

Intensive farming of potatoes in Prince Edward Island (PEI) relies on the repeated and widespread application of fertilizers and pesticides. In PEI the main potato farming areas are in close proximity and drain directly to estuaries. Runoff from high agricultural activity watersheds could impact benthic organism health in the depositional zone of downstream estuaries. The estuarine filter feeder Mya arenaria (soft-shell clam) could be particularly vulnerable to both particle-adsorbed and water soluble contaminants. M. arenaria is susceptible to haemocytic leukemia. In May 2009, we established that heavily proliferated leukemia (HPL) prevalence was generally higher in PEI estuaries located downstream of high intensity potato farming (Dunk and Wilmot estuaries) watersheds than in estuaries downstream of lower intensity areas. Using Mab-1E10 based immunocytochemistry we observed that leukemic haemocytes from the Dunk and Wilmot estuaries were 1E10 negative whereas those from the Ox/Sheep estuary (low potato farming intensity) were 1E10 positive. The expression of genes in the p53 tumour suppressor pathway enabled us to differentiate groups of leukemic and normal M. arenaria, validating our diagnoses. In October 2009, we confirmed that HPL prevalence was elevated in the Dunk and Wilmot estuaries compared to reference (Souris River). Moreover, leukemia prevalence declined with distance from the river mouths along transects through the Dunk and Wilmot estuaries. The pesticides ss-endosulfan and {alpha}-endosulfan were detected in surface sediments from the Dunk and Wilmot estuaries, but not in sediments from either the Souris River or several other lower intensity potato farming watersheds. Our study provides evidence of an association between intensity of potato farming and prevalence of clam leukemia at downstream estuaries in PEI. - Highlights: Black-Right-Pointing-Pointer We examined leukemia prevalence in PEI clams Mya arenaria. Black

Department of Energy Programmatic Environmental Impact Statement (PEIS) scoping session

International Nuclear Information System (INIS)

1992-01-01

The purpose of this programmatic environmental impact statement (PEIS) scoping meeting was: to present the ground water program so as to build some familiarity and understanding about the issue involved; and to get the Durango community's input. This report contains the presentations made by the project manager for the uranium mill tailings program, site manager for the Durango UMTRA site, manager of ground water hydrology, and includes comments made by local residents

IEOH MING PEI: UNA IDEA, TRES VARIACIONES / Ieoh Ming Pei: one idea, three variations

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Alberto Donaire Rodríguez

2010-05-01

Full Text Available RESUMENEl texto siguiente es un resumen de mi lección de despedida, el 18 de noviembre de 2006, al jubilarme en la Escuela de Arquitectura de Sevilla. Como no se grabó y nunca llevo escritas mis clases, ésta es una reconstrucción basada en mi guión y en las notas tomadas por algunos asistentes, a los que agradezco su interés. Por vez primera se celebraba en la Escuela un acto de esta naturaleza, por iniciativa del entonces Director, Jaime Navarro Casas. A él agradezco su presencia y sus palabras, e igualmente a Juan Luis Trillo de Leyva, que hizo una especie de recorrido sentimental de mi paso por la Escuela, que escuché con emoción. En el mismo curso dieron luego su lección de despedida dos profesores que han dejado en nosotros honda huella, Rafael Manzano y José Luis Manzanares. Estos actos son un bello colofón de una carrera académica. La clase fue una reflexión sobre la arquitectura, al hilo del comentario de tres obras del arquitecto Ieoh Ming Pei en tres ciudades diferentes: las ampliaciones de la National Gallery de Washington, del Museo del Louvre de París y del Deutsches Historisches Museum de Berlín. SUMMARYThe following text is a summary of my valedictory lecture, on 18 November 2006, on my retirement from the School of Architecture of Seville. As it was not recorded, and my never having written up my classes, this is a reconstruction based on my outline and the notes taken by some of those present, whom I thank for their interest. This was the first time an act of this nature was held in the School, on the initiative of the then Director, Jaime Navarro Casas. I thank him for his presence and his words, and also Juan Luis Trillo de Leyva, who made a sort of sentimental journey of my time at the School, to which I listened with emotion. Later, valedictory lectures were given by two teachers who have left a profound imprint on us, Rafael Manzano and José Luis Manzanares. These acts are a beautiful conclusion to an

Free volume study on the miscibility of PEEK/PEI blend using positron annihilation and dynamic mechanical thermal analysis

International Nuclear Information System (INIS)

Ramani, R; Alam, S

2015-01-01

High performance polymer blend of poly(ether ether ketone) (PEEK) and poly(ether imide) (PEI) was examined for their free volume behaviour using positron annihilation lifetime spectroscopy and dynamic mechanical thermal analysis methods. The fractional free volume obtained from PALS shows a negative deviation from linear additivity rule implying good miscibility between PEEK and PEI. The dynamic modulus and loss tangent were obtained for the blends at three different frequencies 1, 10 and 100 Hz at temperatures close to and above their glass transition temperature. Applying Time-Temperature-Superposition (TTS) principle to the DMTA results, master curves were obtained at a reference temperature T o and the WLF coefficients c 0 1 and c 0 2 were evaluated. Both the methods give similar results for the dependence of fractional free volume on PEI content in this blend. The results reveal that free volume plays an important role in determining the visco-elastic properties in miscible polymer blends. (paper)

An Evaluation on Transfection Efficiency of pHRE-Egr1-EGFP in Hepatocellular Carcinoma Cells Bel-7402 Mediated by PEI-MZF-NPs

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Mei Lin

2011-01-01

Full Text Available To improve transfection and expression efficiency of target gene, especially under cancer anoxic microenvironment, we have developed pHRE-Egr1-EGFP/PEI-MZF-NPs nanosystem, in which pHRE-Egr1-EGFP, eukaryotic gene expression plasmid, is constructed by combining radiation promoter Egr1 with anoxia induction components (HRE, forming anoxic radiation double sensitive HRE/Egr1 promoter to activate reporter gene EGFP expression. MZF-NPs (Mn0.5 Zn0.5 Fe2O4 magnetic nanoparticles, obtained by coprecipitation method, are coated with cation poly(ethylenimine (PEI. We transferred pHRE-Egr1-EGFP into hepatocellular carcinoma Bel-7402 cells, using PEI-MZF-NPs as the carrier and tested some relevant efficacy. The results show that PEI-MZF-NPs have good DNA-binding ability, protection ability, release ability, little toxicity, and high transfection efficiency, obviously superior to those of the liposome method and electricity perforation method. Moreover, the expression level of EGFP gene induced by anoxia and radiation was significantly higher than that of single radiation activation. It is therefore concluded that HRE/Egr1 can induce and improve target gene expression efficiency in cancer anoxic microenvironment, and that PEI-MZF-NPs can be used as a novel nonviral gene vector which offers a viable approach to the mediated radiation gene therapy of cancer.

The interface modification for GNWs/Si Schottky junction with PEI/PEIE interlayers

Science.gov (United States)

Zhou, Quan; Liu, Xiangzhi; Luo, Wei; Shen, Jun; Wang, Yuefeng; Wei, Dapeng

2018-03-01

Polyethylenimine ethoxylated (PEIE) and polyethyl-enimine (PEI), the two kinds of interface buffer layer, are widely used in the organic light-emitting diodes and solar cells for band alignment adjustment. In this report, we carefully studied the influence of the inserting organic layer on the graphene nanowalls(GNWS)/Si junction quality and the photoresponse of the Schottky devices. We found that thinner layers of PEI could decrease the dark current and improve the photo-to-dark ratio to 105 for n-Si devices. The s-kink effect and degradation of open circuit voltage could be observed for thicker thickness and excessive doping. Relatively, PEIE with stable thin layer not only improve the rectifying characteristics of p-Si devices but also the incident photon conversion efficiency. The maximus IPCE could reach 44% and be adjusted to zero by the reverse bias. The tunneling inhibition for electrons can be alleviated by increasing the barrier height. Our results provide an attractive method to improve the efficiency of pristine GNWs/Si junction with interface doping and passivation.

Cationic lipid-coated PEI/DNA polyplexes with improved efficiency and reduced cytotoxicity for gene delivery into mesenchymal stem cells

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Song HM

2012-08-01

Full Text Available Hongmei Song, Gang Wang, Bin He, Li Li, Caixia Li, Yusi Lai, Xianghui Xu, Zhongwei GuNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan, People's Republic of ChinaBackground: Effective gene transfection without serum deprivation is a prerequisite for successful stem cell-based gene therapy. Polyethylenimine (PEI is an efficient nonviral gene vector, but its application has been hindered by serum sensitivity and severe cytotoxicity.Methods: To solve this problem, a new family of lipopolyplexes was developed by coating PEI/DNA polyplexes with three serum-resistant cationic lipids, namely, lysinylated, histidylated, and arginylated cholesterol. The physical properties, transfection efficiency, cellular uptake, subcellular distribution, and cytotoxicity of the lipopolyplexes was investigated.Results: The outer coat composed of lysinylated or histidylated cholesterol remarkably improved the transfection efficiency of the polyplex with a low PEI/DNA ratio of 2 in the presence of serum. The resulting lysinylated and histidylated cholesterol lipopolyplexes were even more efficient than the best performing polyplex with a high PEI/DNA ratio of 10. Results from cellular uptake and subcellular distribution studies suggest that their higher transfection efficiency may result from accelerated DNA nuclear localization. The superiority of the lipopolyplexes over the best performing polyplex was also confirmed by delivering the therapeutic gene, hVEGF165. Equally importantly, the lipid coating removed the necessity of introducing excess free PEI chains into the transfection solution for higher efficiency, generating lipopolyplexes with no signs of cytotoxicity.Conclusion: Noncovalent modification of polyplexes with lysinylated and histidylated cholesterol lipids can simultaneously improve efficiency and reduce the toxicity of gene delivery under serum conditions, showing great promise for genetic modification of bone

Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma.

Science.gov (United States)

Xie, Yuran; Kim, Na Hyung; Nadithe, Venkatareddy; Schalk, Dana; Thakur, Archana; Kılıç, Ayşe; Lum, Lawrence G; Bassett, David J P; Merkel, Olivia M

2016-05-10

Asthma is a worldwide health problem. Activated T cells (ATCs) in the lung, particularly T helper 2 cells (Th2), are strongly associated with inducing airway inflammatory responses and chemoattraction of inflammatory cells in asthma. Small interfering RNA (siRNA) as a promising anti-sense molecule can specifically silence inflammation related genes in ATCs, however, lack of safe and efficient siRNA delivery systems limits the application of siRNA as a therapeutic molecule in asthma. Here, we designed a novel pulmonary delivery system of siRNA, transferrin-polyethylenimine (Tf-PEI), to selectively deliver siRNA to ATCs in the lung. Tf-PEI polyplexes demonstrated optimal physicochemical properties such as size, distribution, zeta-potential, and siRNA condensation efficiency. Moreover, in vitro studies showed significantly enhanced cellular uptake and gene knockdown mediated by Tf-PEI polyplexes in human primary ATCs. Biodistribution of polyplexes in a murine asthmatic model confirmed that Tf-PEI polyplexes can efficiently and selectively deliver siRNA to ATCs. In conclusion, the present work proves the feasibility to target ATCs in asthma via Tf receptor. This strategy could potentially be used to design an efficient siRNA delivery system for asthma therapy. Copyright © 2016 Elsevier B.V. All rights reserved.

[Maria Goeppert-Mayer Award to Taiwan-born and raised American physicist Michele Ma Chung-pei

CERN Multimedia

2003-01-01

"The American Physical Society conferred the prestigious Maria Goeppert-Mayer Award to Taiwan-born and raised American physicist Michele Ma Chung-pei recently in recognition of her important contributions to theoretical astrophysics" (1 page).

Preparation and characterization of polymer blend based on sulfonated poly (ether ether ketone) and polyetherimide (SPEEK/PEI) as proton exchange membranes for fuel cells

Energy Technology Data Exchange (ETDEWEB)

Hashim, Nordiana; Ali, Ab Malik Marwan [Ionic Material and Devices Research Laboratory, Institute of Science, Universiti Teknologi MARA, 40450 Shah Alam (Malaysia); Lepit, Ajis; Rasmidi, Rosfayanti [Faculty of Applied Sciences, Universiti Teknologi MARA Sabah, Beg Berkunci 71, 88997 Kota Kinabalu (Malaysia); Subban, Ri Hanum Yahaya [Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam (Malaysia); Institute of Science, Universiti Teknologi MARA, 40450 Shah Alam (Malaysia); Yahya, Muhd Zu Azhan [Faculty of Defence Science & Technology, Universiti Pertahanan Nasional Malaysia, 57000 Kuala Lumpur (Malaysia)

2015-08-28

Blends of sulfonated poly (ether ether ketone) (SPEEK) and polyetherimide (PEI) were prepared in five different weight ratios using N-methyl-2-pyrrolidone (NMP) as solvent by the solution cast technique. The degree of sulfonation (DS) of the sulfonated PEEK was determined from deuterated dimethyl sulfoxide (DMSO-d{sub 6}) solution of the purified polymer using {sup 1}H NMR method. The properties studied in the present investigation includes conductivity, water uptake, thermal stability and structure analysis of pure SPEEK as well as SPEEK-PEI polymer blend membranes. The experimental results show that the conductivity of the membranes increased with increase in temperature from 30 to 80°C, except for that of pure SPEEK membrane which increased with temperature from 30 to 60°C while its conductivity decreased with increasing temperature from 60 to 80°C. The conductivity of 70wt.%SPEEK-30wt.%PEI blend membrane at 80% relative humidity (RH) is found to be 1.361 × 10{sup −3} Scm{sup −1} at 30°C and 3.383 × 10{sup −3} Scm{sup −1} at 80°C respectively. It was also found that water uptake and thermal stability of the membranes slightly improved upon blending with PEI. Structure analysis was carried out using Fourier Transform Infrared (FTIR) spectroscopy which revealed considerable interactions between sulfonic acid group of SPEEK and imide groups of PEI. Modification of SPEEK by blending with PEI shows good potential for improving the electrical and physical properties of proton exchange membranes.

N-AC-l-Leu-PEI-mediated miR-34a delivery improves osteogenic differentiation under orthodontic force.

Science.gov (United States)

Yu, Wenwen; Zheng, Yi; Yang, Zhujun; Fei, Hongbo; Wang, Yang; Hou, Xu; Sun, Xinhua; Shen, Yuqin

2017-12-15

Rare therapeutic genes or agents are reported to control orthodontic bone remodeling. MicroRNAs have recently been associated with bone metabolism. Here, we report the in vitro and in vivo effects of miR-34a on osteogenic differentiation under orthodontic force using an N -acetyl-L-leucine-modified polyethylenimine ( N -Ac-l-Leu-PEI) carrier. N -Ac-l-Leu-PEI exhibited low cytotoxicity and high miR-34a transfection efficiency in rat bone mineral stem cells and local alveolar bone tissue. After transfection, miR-34a enhanced the osteogenic differentiation of Runx2 and ColI , Runx2 and ColI protein levels, and early osteogenesis function under orthodontic strain in vitro . MiR-34a also enhanced alveolar bone remodeling under orthodontic force in vivo , as evidenced by elevated gene and protein expression, upregulated indices of alveolar bone anabolism, and diminished tooth movement. We determined that the mechanism miR-34a in osteogenesis under orthodontic force may be associated with GSK-3β. These results suggested that miR-34a delivered by N -Ac-l-Leu-PEI could be a potential therapeutic target for orthodontic treatment.

Effect of miR-146a/bFGF/PEG-PEI Nanoparticles on Inflammation Response and Tissue Regeneration of Human Dental Pulp Cells

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Lu Liu

2016-01-01

Full Text Available Introduction. Inflammation in dental pulp cells (DPCs initiated by Lipopolysaccharide (LPS results in dental pulp necrosis. So far, whether there is a common system regulating inflammation response and tissue regeneration remains unknown. miR-146a is closely related to inflammation. Basic fibroblast growth factor (bFGF is an important regulator for differentiation. Methods. To explore the effect of miR-146a/bFGF on inflammation and tissue regeneration, polyethylene glycol-polyethyleneimine (PEG-PEI was synthesized, and physical characteristics were analyzed by dynamic light scattering and gel retardation analysis. Cell absorption, transfection efficiency, and cytotoxicity were assessed. Alginate gel was combined with miR-146a/PEG-PEI nanoparticles and bFGF. Drug release ratio was measured by ultraviolet spectrophotography. Proliferation and odontogenic differentiation of DPCs with 1 μg/mL LPS treatment were determined. Results. PEG-PEI prepared at N/P 2 showed complete gel retardation and smallest particle size and zeta potential. Transfection efficiency of PEG-PEI was higher than lipo2000. Cell viability decreased as N/P ratio increased. Drug release rate amounted to 70% at the first 12 h and then maintained slow release afterwards. Proliferation and differentiation decreased in DPCs with LPS treatment, whereas they increased in miR-146a/bFGF gel group. Conclusions. PEG-PEI is a promising vector for gene therapy. miR-146a and bFGF play critical roles in inflammation response and tissue regeneration of DPCs.

Characterization of PEI-coated superparamagnetic iron oxide nanoparticles for transfection: Size distribution, colloidal properties and DNA interaction

Energy Technology Data Exchange (ETDEWEB)

Steitz, Benedikt [Laboratory of Powder Technology, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne (Switzerland); Hofmann, Heinrich [Laboratory of Powder Technology, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne (Switzerland); Kamau, Sarah W. [Institute of Veterinary Biochemistry and Molecular Biology, University of Zuerich, Zurich (Switzerland); Hassa, Paul O. [Institute of Veterinary Biochemistry and Molecular Biology, University of Zuerich, Zurich (Switzerland); Hottiger, Michael O. [Institute of Veterinary Biochemistry and Molecular Biology, University of Zuerich, Zurich (Switzerland); Rechenberg, Brigitte von [Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty Zurich, University of Zurich, Winterthurerstr. 260, 8057 Zurich (Switzerland); Hofmann-Amtenbrink, Magarethe [MatSearch, Chemin Jean Pavillard 14, 1009 Pully (Switzerland); Petri-Fink, Alke [Laboratory of Powder Technology, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne (Switzerland)]. E-mail: alke.fink@epfl.ch

2007-04-15

Superparamagnetic iron oxide nanoparticles (SPIONs) were coated with polyethylenimine. Here, we briefly describe the synthesis as well as DNA:PEI:SPION complexes and the characterization of the compounds according to their particle size, {zeta}-potential, morphology, DNA complexing ability, magnetic sedimentation, and colloidal stability. PEI coating of SPIONs led to colloidally stable beads even in high salt concentrations over a wide pH range. DNA plasmids and PCR products encoding for green fluorescent protein were associated with the described beads. The complexes were added to cells and exposed to permanent and pulsating magnetic fields. Presence of these magnetic fields significantly increased the transfection efficiency.

Characterization of PEI-coated superparamagnetic iron oxide nanoparticles for transfection: Size distribution, colloidal properties and DNA interaction

International Nuclear Information System (INIS)

Steitz, Benedikt; Hofmann, Heinrich; Kamau, Sarah W.; Hassa, Paul O.; Hottiger, Michael O.; Rechenberg, Brigitte von; Hofmann-Amtenbrink, Magarethe; Petri-Fink, Alke

2007-01-01

Superparamagnetic iron oxide nanoparticles (SPIONs) were coated with polyethylenimine. Here, we briefly describe the synthesis as well as DNA:PEI:SPION complexes and the characterization of the compounds according to their particle size, ζ-potential, morphology, DNA complexing ability, magnetic sedimentation, and colloidal stability. PEI coating of SPIONs led to colloidally stable beads even in high salt concentrations over a wide pH range. DNA plasmids and PCR products encoding for green fluorescent protein were associated with the described beads. The complexes were added to cells and exposed to permanent and pulsating magnetic fields. Presence of these magnetic fields significantly increased the transfection efficiency

[Decipherment and annotation of some terms in the remnant scrolls of Hui hui yao fang (Huihui Formularies)].

Science.gov (United States)

Huang, Y; Wang, J

2017-05-28

The etymology of the terms in Hui hui yao fang ( Huihui Formularies ) is complicated. Their origin might be Arabian, Persian, or Sanskrit, or even the northern dialects of Han language during the Yuan and Ming Dynasties. There are obvious mistakes or indefinite decipherments and interpretations of the terms in Song Xian's Investigated Annotations of Huihui Formularies . There are also missing annotations for those transliterated terms. To tackle such defects, 12 such terms are deciphered and annotated here.

Henry Moore’s Public Sculpture in the US: The Collaborations with I. M. Pei

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Alex Potts

2016-07-01

Full Text Available The many commissions Henry Moore received for public sculpture in the United States provided the occasion for several quite distinctive works. While not site specific, these were unique, and their final form, scale, and disposition was elaborated with a particular setting in mind. This aspect of Moore’s work in the US, which began with the monumental piece he designed for the Lincoln Center in New York in 1963–65, is examined here by focusing on the productive relationship he forged with the architect I. M. Pei in the 1970s. The sculptures Moore produced in collaboration with Pei respond in suggestive ways to the spatial environments created in American cities by late modern architectural developments. They also realize an oddly effective combination of the biomorphic and abstract that differs both from the bodily conception of Moore’s earlier work and the non-figurative character of much public sculpture of the time.

Hypoxia-inducible bidirectional shRNA expression vector delivery using PEI/chitosan-TBA copolymers for colorectal Cancer gene therapy.

Science.gov (United States)

Javan, Bita; Atyabi, Fatemeh; Shahbazi, Majid

2018-04-12

This investigation was conducted to construct a hypoxia/colorectal dual-specific bidirectional short hairpin RNA (shRNA) expression vector and to transfect it into the colon cancer cell line HT-29 with PEI/chitosan-TBA nanoparticles for the simultaneous knock down of β-catenin and Bcl-2 under hypoxia. To construct a pRNA-bipHRE-CEA vector, the carcinoma embryonic antigen (CEA) promoter designed in two directions and the vascular endothelial growth factor (VEGF) enhancer were inserted between two promoters for hypoxic cancer specific gene expression. To confirm the therapeutic effect of the dual-specific vector, β-catenin and Bcl-2 shRNAs were inserted downstream of each promoter. The physicochemical properties, the cytotoxicity, and the transfection efficiency of these PEI/chitosan-TBA nanoparticles were investigated. In addition, the antitumor effects of the designed vector on the expression of β-catenin and Bcl-2, cell cycle distribution, and apoptosis were investigated in vitro. The silencing effect of the hypoxia-response shRNA expression vector was relatively low (18%-25%) under normoxia, whereas it was significantly increased to approximately 50%-60% in the HT-29 cell line. Moreover, the cancer cells showed significant G0/G1 arrest and increased apoptosis due to gene silencing under hypoxia. Furthermore, MTS assay, fluorescence microscopy images, and flow cytometry analyses confirmed that the PEI/chitosan-TBA blend system provided effective transfection with low cytotoxicity. This novel hypoxia-responsive shRNA expression vector may be useful for RNA interference (RNAi)-based cancer gene therapy in hypoxic colorectal tumors. Moreover, the PEI/chitosan-TBA copolymer might be a promising gene carrier for use in gene transfer in vivo. Copyright © 2017. Published by Elsevier Inc.

Amperometric Immunosensor for Carbofuran Detection Based on MWCNTs/GS-PEI-Au and AuNPs-Antibody Conjugate

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Xiangyou Wang

2013-04-01

Full Text Available In this paper, an amperometric immunosensor for the detection of carbofuran was developed. Firstly, multiwall carbon nanotubes (MWCNTs and graphene sheets-ethyleneimine polymer-Au (GS-PEI-Au nanocomposites were modified onto the surface of a glass carbon electrode (GCE via self-assembly. The nanocomposites can increase the surface area of the GCE to capture a large amount of antibody, as well as produce a synergistic effect in the electrochemical performance. Then the modified electrode was coated with gold nanoparticles-antibody conjugate (AuNPs-Ab and blocked with BSA. The monoclonal antibody against carbofuran was covalently immobilized on the AuNPs with glutathione as a spacer arm. The morphologies of the GS-PEI-Au nanocomposites and the fabrication process of the immunosensor were characterized by X-ray diffraction (XRD, ultraviolet and visible absorption spectroscopy (UV-vis and scanning electron microscopy (SEM, respectively. Under optimal conditions, the immunosensor showed a wide linear range, from 0.5 to 500 ng/mL, with a detection limit of 0.03 ng/mL (S/N = 3. The as-constructed immunosensor exhibited notable performance features such as high specificity, good reproducibility, acceptable stability and regeneration performance. The results are mainly due to the excellent properties of MWCNTs, GS-PEI-Au nanocomposites and the covalent immobilization of Ab with free hapten binding sites for further immunoreaction. It provides a new avenue for amperometric immunosensor fabrication.

76 FR 22724 - Draft Program Environmental Impact Statement/Environmental Impact Report (PEIS/R) and Public...

Science.gov (United States)

2011-04-22

...). The Draft PEIS/R document evaluates the direct, indirect, and cumulative effects of implementing the... fax at 916-978-5469, or e-mail at [email protected] . Additional information is available online at... Department of Fish and Game (DFG), will work to implement the Settlement. Reclamation, on behalf of the...

Polylysine-modified polyethylenimine (PEI-PLL) mediated VEGF gene delivery protects dopaminergic neurons in cell culture and in rat models of Parkinson's Disease (PD).

Science.gov (United States)

Sheikh, Muhammad Abid; Malik, Yousra Saeed; Xing, Zhenkai; Guo, Zhaopei; Tian, Huayu; Zhu, Xiaojuan; Chen, Xuesi

2017-05-01

Parkinson's Disease (PD) is a chronic neurodegenerative disorder characterized by motor deficits which result from the progressive loss of dopaminergic neurons. Gene therapy using growth factors such as VEGF seems to be a viable approach for potential therapeutic treatment of PD. In this study, we utilized a novel non-viral gene carrier designated as PEI-PLL synthesized by our laboratory to deliver VEGF gene to study its effect by using both cell culture as well as animal models of PD. For cell culture experiments, we utilized 6-hydroxydopamine (6-OHDA) mediated cell death model of MN9D cells following transfection with either a control plasmid or VEGF expressing plasmid. As compared to control transfected cells, PEI-PLL mediated VEGF gene delivery to MN9D cells resulted in increased cell viability, increase in the number of Tyrosine hydroxylase (TH) positive cells and decreased apoptosis following 6-OHDA insult. Next, we studied the therapeutic potential of PEI-PLL mediated VEGF gene delivery in SNPc by using unilateral 6-OHDA Medial forebrain bundle (MFB) lesion model of PD in rats. VEGF administration prevented the loss of motor functions induced by 6-OHDA as determined by behavior analysis. Similarly, VEGF inhibited the 6-OHDA mediated loss of DA neurons in Substantia Nigra Pars Compacta (SNPc) as well as DA nerve fibers in striatum as determined by TH immunostaining. In addition, PEI-PLL mediated VEGF gene delivery also prevented apoptosis and microglial activation in PD rat models. Together, these results clearly demonstrated the beneficial effects of PEI-PLL mediated VEGF gene delivery on dopaminergic system in both cell culture and animal models of PD. In this report, we exploited the potential of PEI-PLL to deliver VEGF gene for the potential therapeutic treatment of PD by using both cell culture and animal models of PD. To the best of our knowledge, this is the first report describing the use of novel polymeric gene carriers for the delivery of VEGF gene

Ergonomic Analysis of Garment Industry using Posture Evaluation Index (PEI in Virtual Environment

Directory of Open Access Journals (Sweden)

Erlinda Muslim

2011-09-01

Full Text Available This research tried to study, in a virtual environment, the ergonomics of four divisions in garment industry: cutting division, sewing division, button division, and finishing division. Variables that influence the working conditions in each division are different; depend on the real situations that happened. The purpose is to assess the real working conditions based on ergonomics  study  using Posture Evaluation Index (PEI. PEI integrates  the scores of  low back analysis (LBA, ovako working  posture  (OWAS,  and  rapid  upper  limb assessment  (RULA.  Analysis  phase  was  done  using  digital  human model  in  virtual  environment  that  available  on  Jack  6.0.  The  results show  that  the  working  conditions  in  garment industry had enough amount of risk that can injured the musculoskeletal system of the workers. This research enriches the  body  of  ergonomics  knowledge  in Indonesia  because  it  is  the  first  research  in  Indonesia that  applied  virtual environment approach to ergonomics analysis in industry.

Fluorescence turn-on detection of alkaline phosphatase activity based on controlled release of PEI-capped Cu nanoclusters from MnO2 nanosheets.

Science.gov (United States)

Zhang, Yunyi; Li, Yongxin; Zhang, Cuiyun; Zhang, Qingfeng; Huang, Xinan; Yang, Meiding; Shahzad, Sohail Anjum; Lo, Kenneth Kam-Wing; Yu, Cong; Jiang, Shichun

2017-08-01

A fluorescence turn-on assay for alkaline phosphatase (ALP) activity is developed through the controlled release of polyethyleneimine-capped copper nanoclusters (PEI-capped CuNCs) from the MnO 2 nanosheets. In an aqueous solution, the positively charged PEI-capped CuNCs could be adsorbed onto the surface of the negatively charged MnO 2 nanosheets. Such adsorption through favorable electrostatic interactions could efficiently quench the nanocluster fluorescence emission via resonance energy transfer from the PEI-capped CuNCs to the MnO 2 nanosheets. 2-Phospho-L-ascorbic acid (AAP) could be hydrolyzed to L-ascorbic acid (AA) in the presence of ALP. AA could reduce MnO 2 into Mn 2+ and trigger the disintegration of the MnO 2 nanosheets. As a result, the CuNCs were released and the quenched fluorescence was recovered efficiently. The detection strategy is simple, inexpensive, sensitive, selective, with low toxicity, and has better biocompatibility. The newly fabricated biosensor for ALP activity will potentially make it a robust candidate for numerous biological and biomedical applications.

Hanford Site environmental setting data developed for the unit risk factor methodology in support of the Programmatic Environmental Impact Statement (PEIS)

International Nuclear Information System (INIS)

Schramke, J.A.; Glantz, C.S.; Holdren, G.R.

1994-05-01

This report describes the environmental settings identified for the Hanford Site in support of the US Department of Energy's (DOE's) Programmatic Environmental Impact Study (PEIS). The objective of the PEIS is to provide the public with information about the types of waste and contamination problems associated with major DOE facilities across the country and to assess the relative risks that these wastes pose to the public, onsite workers, and the environment. The environmental setting information consists of the site-specific data required to model (using the Multimedia Environmental Pollutant Assessment System) the atmospheric, groundwater, and surface-water transport of contaminants within the boundaries of the Hanford Site. The environmental setting data describes the climate, atmospheric dispersion, hydrogeology, and surface-water characteristics of the Site. The number of environmental settings developed for the Hanford Site was the fewest that could provide accurate results when used in the risk assessment modeling. Environmental settings for Hanford were developed in conjunction with local experts in the fields of meteorology, geology, hydrology, and geochemistry. Site experts participated in the initial development, fine-tuning, and final review of Hanford's PEIS environmental settings

The Effect of PEI and PVP-Stabilized Gold Nanoparticles on Equine Platelets Activation: Potential Application in Equine Regenerative Medicine

Directory of Open Access Journals (Sweden)

Mateusz Hecold

2017-01-01

Full Text Available The aim of this work was to assess the effect of different stabilizing agents, for example, polyethylenimine (PEI and polyvinylpyrrolidone (PVP, on gold nanoparticles (AuNPs and their influence on equine platelet activation and release of particular growth factors. The gold nanoparticles were produced by chemical reduction of chloroauric acid. UV-Vis spectroscopy confirmed the presence of gold nanoparticles in investigated solutions. The AuNPs were incubated with whole blood at various concentrations. The morphology of platelets in PRP prepared from the blood incubated with AuNPs was characterized by scanning transmission electron microscopy, whereas the concentrations of growth factors and cytokines were evaluated by ELISA assays. The most promising results were obtained with equine platelets incubated with 5% AuNPs stabilized by PEI, which lead to secretion of bone morphogenetic protein 2 (BMP-2, vascular endothelial growth factor (VEGF, and fibroblast growth factor 1 (FGF-1 and simultaneously cause decrease in concentration of interleukin-1 alpha (IL-1α. The qRT-PCR confirmed ELISA test results. The incubation with 5% AuNPs stabilized by PEI leads to upregulation of BMP-2 and VEGF transcripts of mRNA level and to downregulating expression of interleukin-6 (IL-6. Obtained data shed a promising light on gold nanoparticle application for future regenerative medicine application.

STRUCTURAL CHARACTERIZATION AND GAS PERMEATION PROPERTIES OF POLYETHERIMIDE (PEI/ZEOLITIC IMIDAZOLATE (ZIF-11 MIXED MATRIX MEMBRANES

Directory of Open Access Journals (Sweden)

Mehtap Şafak Boroğlu

2016-06-01

Full Text Available In this study, the preparation of polyetherimide (PEI-Ultem1000/ZIF-11 mixed matrix membranes was studied in various ZIF-11 nanoparticles loadings (0, 10, 15, 20, and 30 wt.%. The newly synthesized ZIF-11 nanoparticles with an average particle size of ~280 nm were integrated in PEI membranes as novel mixed matrix membranes (MMMs. The effect of ZIF-11 loading was scrutinised for H2, CO2, and CH4 gas separation performance at 35 °C and 4 bar. The incorporation of ZIF-11 nanoparticles improved the gas permeation properties of the MMMs with an increase in ZIF-11 loading. As the ZIF-11 loading increased up to 20 wt.%, the permeability of H2 and CO2 increased to four times higher than that of the pure polymer. Moderate increase of CH4 permeability was also recorded. At higher loadings above 20 wt.%, the permeability decreased for all gases and the CO2/CH4, and H2/CH4 selectivities increased consistent with the ZIF-11 loading.

Combination of adenovirus and cross-linked low molecular weight PEI improves efficiency of gene transduction

International Nuclear Information System (INIS)

Han Jianfeng; Zhao Dong; Zhong Zhirong; Zhang Zhirong; Gong Tao; Sun Xun

2010-01-01

Recombinant adenovirus (Ad)-mediated gene therapy is an exciting novel strategy in cancer treatment. However, poor infection efficiency with coxsackievirus and adenovirus receptor (CAR) down-regulated cancer cell lines is one of the major challenges for its practical and extensive application. As an alternative method of viral gene delivery, a non-viral carrier using cationic materials could compensate for the limitation of adenovirus. In our study, adenovectors were complexed with a new synthetic polymer PEI-DEG-bis-NPC (PDN) based on polyethylenimine (PEI), and then the properties of the vehicle were characterized by measurement of size distribution, zeta potential and transmission electron microscopy (TEM). Enhancement of gene transduction by Ad/PDN complexes was observed in both CAR-overexpressing cell lines (A549) and CAR-lacking cell lines (MDCK, CHO, LLC), as a result of facilitating binding and cell uptake of adenoviral particles by the cationic component. Ad/PDN complexes also promoted the inhibition of tumor growth in vivo and prolonged the survival time of tumor-bearing mice. These data suggest that a combination of viral and non-viral gene delivery methods may offer a new approach to successful cancer gene therapy.

A novel unstable duplication upstream of HAS2 predisposes to a breed-defining skin phenotype and a periodic fever syndrome in Chinese Shar-Pei dogs.

Directory of Open Access Journals (Sweden)

Mia Olsson

2011-03-01

Full Text Available Hereditary periodic fever syndromes are characterized by recurrent episodes of fever and inflammation with no known pathogenic or autoimmune cause. In humans, several genes have been implicated in this group of diseases, but the majority of cases remain unexplained. A similar periodic fever syndrome is relatively frequent in the Chinese Shar-Pei breed of dogs. In the western world, Shar-Pei have been strongly selected for a distinctive thick and heavily folded skin. In this study, a mutation affecting both these traits was identified. Using genome-wide SNP analysis of Shar-Pei and other breeds, the strongest signal of a breed-specific selective sweep was located on chromosome 13. The same region also harbored the strongest genome-wide association (GWA signal for susceptibility to the periodic fever syndrome (p(raw = 2.3 × 10⁻⁶, p(genome = 0.01. Dense targeted resequencing revealed two partially overlapping duplications, 14.3 Kb and 16.1 Kb in size, unique to Shar-Pei and upstream of the Hyaluronic Acid Synthase 2 (HAS2 gene. HAS2 encodes the rate-limiting enzyme synthesizing hyaluronan (HA, a major component of the skin. HA is up-regulated and accumulates in the thickened skin of Shar-Pei. A high copy number of the 16.1 Kb duplication was associated with an increased expression of HAS2 as well as the periodic fever syndrome (p < 0.0001. When fragmented, HA can act as a trigger of the innate immune system and stimulate sterile fever and inflammation. The strong selection for the skin phenotype therefore appears to enrich for a pleiotropic mutation predisposing these dogs to a periodic fever syndrome. The identification of HA as a major risk factor for this canine disease raises the potential of this glycosaminoglycan as a risk factor for human periodic fevers and as an important driver of chronic inflammation.

[Needling technique of Professor Li Yan-Fang].

Science.gov (United States)

Li, Li-Jun

2014-01-01

Experiences of needling techniques of Professor LI Ya- fang is introduced in this article. Gentle and superficial insertion is adopted by Professor LI in clinic. Emphases are put on the qi regulation function, needling sensation to the affected region and insertion with both hands, especially the function of the left hand as pressing hand. The gentle and superficial insertion should be done as the follows: hold the needle with the right hand, press gently along the running course of meridians with the left hand to promote qi circulation, hard pressing should be applied at acupoints to disperse the local qi and blood, insert the needle gently and quickly into the subcutaneous region with the right hand, and stop the insertion when patient has the needling sensation. While the fast needling is characterized with shallow insertion and swift manipulation: the left hand of the manipulator should press first along the running course of the meridian, and fix the local skin, hold the needle with the right hand and insert the needle quickly into the acupoint. Withdrawal of the needle should be done immediately after the reinforcing and reducing manipulations. Professor LI is accomplished in qi regulation. It is held by him that regulating qi circulation is essence of acupuncture, letting the patient get the needling sensation is the most important task of needling. Lifting, thrusting and rotation manipulations should be applied to do reinforcing or reducing. The tissue around the tip of the needle should not be too contracted or too relaxed, and the resistance should not be too strong or too weak. The feeling of the insertion hand of the practitioner should not be too smooth or too hesitant. Needle should be inserted into the skin quickly at the moment of hard pressing by the left hand. And then, slow rotation and gentle lifting and thrusting can be applied to promote the needling sensation like electric current pass through and to reach the affected region along the

San Francisco folio, California, Tamalpais, San Francisco, Concord, San Mateo, and Haywards quadrangles

Science.gov (United States)

Lawson, Andrew Cowper

1914-01-01

The five sheets of the San Francisco folio the Tamalpais, Ban Francisco, Concord, Ban Mateo, and Haywards sheets map a territory lying between latitude 37° 30' and 38° and longitude 122° and 122° 45'. Large parts of four of these sheets cover the waters of the Bay of San Francisco or of the adjacent Pacific Ocean. (See fig. 1.) Within the area mapped are the cities of San Francisco, Oakland, Berkeley, Alameda, Ban Rafael, and San Mateo, and many smaller towns and villages. These cities, which have a population aggregating about 750,000, together form the largest and most important center of commercial and industrial activity on the west coast of the United States. The natural advantages afforded by a great harbor, where the railways from the east meet the ships from all ports of the world, have determined the site of a flourishing cosmopolitan, commercial city on the shores of San Francisco Bay. The bay is encircled by hilly and mountainous country diversified by fertile valley lands and divides the territory mapped into two rather contrasted parts, the western part being again divided by the Golden Gate. It will therefore be convenient to sketch the geographic features under four headings (1) the area east of San Francisco Bay; (2) the San Francisco Peninsula; (3) the Marin Peninsula; (4) San Francisco Bay. (See fig. 2.)

Hiatal hernia in the dog: a clinical report of four Chinese shar peis.

Science.gov (United States)

Guiot, Laurent P; Lansdowne, Jennifer L; Rouppert, Pierre; Stanley, Bryden J

2008-01-01

Four Chinese shar pei littermate puppies were presented for vomiting, regurgitation, hypersalivation, and poor growth. Diagnosis of hiatal hernia was made for each of the four dogs based on survey radiographs and barium esophagram studies. All dogs initially underwent medical therapy, to which only one dog responded. All dogs underwent surgical treatment, which included manual hernia reduction followed by phrenoplasty, esophagopexy, and left incisional gastropexy, 5 to 40 days following initiation of medical therapy. The three surgical techniques described eliminated the need to enter the pleural cavity and offered excellent long-term results with no recurrence of clinical signs following surgery.

A política externa independente (PEI): antecedentes, apogeu e declínio

OpenAIRE

Manzur,Tânia Maria P. G.

2014-01-01

Este artigo analisa o período de 1961 a 1964, quando a sociedade brasileira vivenciou o processo de gestação, desenvolvimento, apogeu e declínio da Política Externa Independente (PEI). Na vigência das presidências de Jânio Quadros e, posteriormente, João Goulart, observa-se expressivo envolvimento da opinião pública com assuntos de política exterior, envolvimento esse que é fruto de um amálgama entre o populismo e o desenvolvimento e a disseminação dos meios de comunicação de massa, bem como ...

Eficácia do Programa de Enriquecimento Instrumental-PEI, versão básica, em crianças com transtornos do neurodesenvolvimento (TDAH e Dislexia)

OpenAIRE

Ricci, Karen Alves

2016-01-01

O Programa de Enriquecimento Instrumental (PEI), de Reuven Feuerstein, tem por objetivo aumentar o nível de modificabilidade cognitiva e a capacidade de aprendizagem, porém raras são as pesquisas sobre a eficácia do PEI, versão básica, em transtornos do neurodesenvolvimento. Na presente pesquisa foram abordados dois transtornos do neurodesenvolvimento, o Transtorno do déficit de atenção e hiperatividade (TDAH), caracterizado por níveis prejudiciais de desatenção, desorganização e/ou hiperativ...

Folic acid conjugated mPEG-PEI600 as an efficient non-viral vector for targeted nucleic acid delivery.

Science.gov (United States)

Xu, Zhenhua; Jin, Jiefu; Siu, Leo K S; Yao, Hong; Sze, Johnny; Sun, Hongzhe; Kung, Hsiang-Fu; Poon, Wai Sang; Ng, Samuel S M; Lin, Marie C

2012-04-15

In this study we describe a novel polymer, mPPS-FA, synthesized as a potential gene transfer vector. To complete mPPS-FA, folic acid was conjugated to a backbone (named mPPS) consisting of a copolymer of methyl PEG-2000, PEI-600, and sebacoyl chloride. (1)H NMR, FT-IR, and UV spectroscopy were used to characterize the structure of mPPS-FA. It was revealed that mPPS-FA holds the ability to bind plasmid DNA yielding positively charged particles (polyplexes). Dynamic light scattering (DLS) and TEM techniques were used to study the size and morphology of the formed mPPS-FA/DNA nanocomplexes. The mPPS-FA/DNA nanoparticles exhibited low cytotoxicity as transfection of B16-F0, U87MG, CHO-1, and Ho-8910 cells produced >80% viability indicating low cytotoxicity of the polymer. The ability of mPPS-FA to deliver EGFP plasmid to melanoma B16-F0, U87, CHO-1, Ho-8910, and A549 cells was investigated in vitro as compared to the lipid-based transfection agent Lipofectamine2000 and Linear PEI 22 kDa (L-PEI 22 kDa). We found that mPPS-FA/DNA complexes yielded the highest GFP transfection efficiency in B16-F0, U87, CHO-1, and Ho-8910 cells, which all highly express folate receptors (FR), at an mPPS-FA/DNA ratio (w/w) of 15. Furthermore, the transfection of mPPS-FA/DNA complexes in CHO-1 cells could be competitively blocked by free folic acid molecules. In contrast, in low FR expressing A549 cells, mPPS-FA showed similar low transfection efficiency as mPPS. Taken together, mPPS-FA showed the highest efficiency in vitro and the potential to be developed as a nonviral gene carrier. Copyright © 2012 Elsevier B.V. All rights reserved.

75 FR 38412 - Safety Zone; San Diego POPS Fireworks, San Diego, CA

Science.gov (United States)

2010-07-02

...-AA00 Safety Zone; San Diego POPS Fireworks, San Diego, CA AGENCY: Coast Guard, DHS. ACTION: Temporary... waters of San Diego Bay in support of the San Diego POPS Fireworks. This safety zone is necessary to... San Diego POPS Fireworks, which will include fireworks presentations conducted from a barge in San...

Long-term results of interventional treatment of large unresectable hepatocellular carcinoma (HCC): significant survival benefit from combined transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) compared to TACE monotherapy; Langzeitergebnisse der interventionellen Therapie von grossen, inoperablen hepatozellulaeren Karzinomen (HCC): signifikanter Ueberlebensvorteil von transarterieller Chemoembolisation (TACE) und perkutaner Ethanolinjektion (PEI) gegenueber der TACE-Monotherapie

Energy Technology Data Exchange (ETDEWEB)

Lubienski, A.; Bitsch, R.G.; Grenacher, L.; Kauffmann, G.W. [Radiologische Universitaetsklinik Heidelberg, Abt. Radiodiagnostik, Heidelberg (Germany); Schemmer, P. [Chirurgische Universitaetsklinik Heidelberg (Germany); Duex, M. [Radiologisches Zentralinstitut Krankenhaus Nordwest Frankfurt (Germany)

2004-12-01

Purpose: A retrospective analysis of long-term efficacy of combined transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) and TACE monotherapy was conducted in patients with large, non-resectable hepatocellular carcinoma (HCC). Methods and Materials: Fifty patients with large, unresectable HCC lesions underwent selective TACE. Liver cirrhosis was present in 42 patients, due to alcohol abuse (n = 22) and viral infection (n = 17). In three patients, the underlying cause for liver cirrhosis remained unclear. Child A cirrhosis was found in 22 and Child B cirrhosis in 20 patients. Repeated and combined TACE and PEI were performed in 22 patients and repeated TACE monotherapy was performed in 28 patients. Survival and complication rates were determined and compared. Results: The 6-, 12-, 24- and 36-month survival rates were 61%, 21%, 4%, and 4% for TACE monotherapy and 77%, 55%, 39% and 22% for combined TACE and PEI (Kaplan-Meier method). The kind of treatment significantly affected the survival rate (p=0.002 log-rank test). Severe side effects were present in two patients of the monotherapy group and in three patients of the combination therapy group. (orig.)

Fissile Material Disposition Program: Deep Borehole Disposal Facility PEIS data input report for direct disposal. Direct disposal of plutonium metal/plutonium dioxide in compound metal canisters. Version 3.0

Energy Technology Data Exchange (ETDEWEB)

Wijesinghe, A.M.; Shaffer, R.J.

1996-01-15

The US Department of Energy (DOE) is examining options for disposing of excess weapons-usable nuclear materials [principally plutonium (Pu) and highly enriched uranium (HEU)] in a form or condition that is substantially and inherently more difficult to recover and reuse in weapons production. This report is the data input report for the Programmatic Environmental Impact Statement (PEIS). The PEIS examines the environmental, safety, and health impacts of implementing each disposition alternative on land use, facility operations, and site infrastructure; air quality and noise; water, geology, and soils; biotic, cultural, and paleontological resources; socioeconomics; human health; normal operations and facility accidents; waste management; and transportation. This data report is prepared to assist in estimating the environmental effects associated with the construction and operation of a Deep Borehole Disposal Facility, an alternative currently included in the PEIS. The facility projects under consideration are, not site specific. This report therefore concentrates on environmental, safety, and health impacts at a generic site appropriate for siting a Deep Borehole Disposal Facility.

Fissile Material Disposition Program: Deep Borehole Disposal Facility PEIS data input report for direct disposal. Direct disposal of plutonium metal/plutonium dioxide in compound metal canisters. Version 3.0

International Nuclear Information System (INIS)

Wijesinghe, A.M.; Shaffer, R.J.

1996-01-01

The US Department of Energy (DOE) is examining options for disposing of excess weapons-usable nuclear materials [principally plutonium (Pu) and highly enriched uranium (HEU)] in a form or condition that is substantially and inherently more difficult to recover and reuse in weapons production. This report is the data input report for the Programmatic Environmental Impact Statement (PEIS). The PEIS examines the environmental, safety, and health impacts of implementing each disposition alternative on land use, facility operations, and site infrastructure; air quality and noise; water, geology, and soils; biotic, cultural, and paleontological resources; socioeconomics; human health; normal operations and facility accidents; waste management; and transportation. This data report is prepared to assist in estimating the environmental effects associated with the construction and operation of a Deep Borehole Disposal Facility, an alternative currently included in the PEIS. The facility projects under consideration are, not site specific. This report therefore concentrates on environmental, safety, and health impacts at a generic site appropriate for siting a Deep Borehole Disposal Facility

Construction of non-viral vector (mPEG5k-PCL1.2k)1.4-g-PEI10k and its gene delivery efficacy in vitro

OpenAIRE

Wei HUANG; Ming LV; Zhong-gao GAO; Ming-ji JIN; Fei-fei YANG; Yu-li WANG

2011-01-01

Objective To construct(mPEG5k-PCL1.2k)1.4-g-PEI10k,a copolymer designed as delivery vector for non-viral gene therapy,and explore its cytotoxicity and efficacy in delivery of plasmid DNA(pDNA).Methods The copolymer,mPEG5k-PCL1.2k-OH,was prepared by ring-opening polymerization and then followed by a conversion of hydroxyl terminal(-OH) into N-hydroxysuccinimide(NHS) to prepare mPEG5k-PCL1.2k-NHS.One of the branches,PEI10k,was then reacted with mPEG5k-PCL1.2k-NHS to synthesize a ternary copolym...

Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam.

Science.gov (United States)

Pla, Davinia; Petras, Daniel; Saviola, Anthony J; Modahl, Cassandra M; Sanz, Libia; Pérez, Alicia; Juárez, Elena; Frietze, Seth; Dorrestein, Pieter C; Mackessy, Stephen P; Calvete, Juan J

2018-03-01

The Brown Treesnake (Boiga irregularis) is an arboreal, nocturnal, rear-fanged venomous snake native to northern and eastern regions of Australia, Papua New Guinea and the Solomon Islands. It was inadvertently introduced onto the island of Guam during the late 1940's to early 1950's, and it has caused massive declines and extirpations of the native bird, lizard, and mammal populations. In the current study, we report the characterization of the venom proteome of an adult and a neonate B. irregularis specimens from Guam by a combination of venom gland transcriptomic and venomic analyses. Venom gland transcriptomic analysis of an adult individual identified toxins belonging to 18 protein families, with three-finger toxin isoforms being the most abundantly expressed transcripts, comprising 94% of all venom protein transcript reads. Transcripts for PIII-metalloproteinases, C-type lectins, cysteine-rich secretory proteins, acetylcholinesterases, natriuretic peptides, ficolins, phospholipase A 2 (PLA 2 ) inhibitors, PLA 2 s, vascular endothelial growth factors, Kunitz-type protease inhibitors, cystatins, phospholipase Bs, cobra venom factors, waprins, SVMP inhibitors, matrix metalloproteinases, and hyaluronidases were also identified, albeit, at very low abundances ranging from 0.05% to 1.7% of the transcriptome. The venom proteomes of neonate and adult B. irregularis were also both overwhelmingly (78 and 84%, respectively) dominated by monomeric and dimeric 3FTxs, followed by moderately abundant (21% (N) and 13% (A)) CRISPs, low abundance (1% (N), 3% (A)) PIII-SVMPs, and very low abundance (blot analysis showed that all venom proteins were recognized by anti-BTS IgGs, and cross-reactivity with other rear-fanged snake venoms was also observed. Incubation of anti-BTS venom IgGs with crude B. irregularis venom resulted in a significant decrease in proteolytic (SVMP) activity against azocasein. These results provide the first comparative venomic and anti-venomic analysis of

78 FR 19103 - Safety Zone; Spanish Navy School Ship San Sebastian El Cano Escort; Bahia de San Juan; San Juan, PR

Science.gov (United States)

2013-03-29

...-AA00 Safety Zone; Spanish Navy School Ship San Sebastian El Cano Escort; Bahia de San Juan; San Juan... temporary moving safety zone on the waters of Bahia de San Juan during the transit of the Spanish Navy... Channel entrance, and to protect the high ranking officials on board the Spanish Navy School Ship San...

Compact High Resolution SANS using very cold neutrons (VCN-SANS)

International Nuclear Information System (INIS)

Kennedy, S.; Yamada, M.; Iwashita, Y.; Geltenbort, P.; Bleuel, M.; Shimizu, H.

2011-01-01

SANS (Small Angle Neutron Scattering) is a popular method for elucidation of nano-scale structures. However science continually challenges SANS for higher performance, prompting exploration of ever-more exotic and expensive technologies. We propose a compact high resolution SANS, using very cold neutrons, magnetic focusing lens and a wide-angle spherical detector. This system will compete with modern 40 m pinhole SANS in one tenth of the length, matching minimum Q, Q-resolution and dynamic range. It will also probe dynamics using the MIEZE method. Our prototype lens (a rotating permanent-magnet sextupole), focuses a pulsed neutron beam over 3-5 nm wavelength and has measured SANS from micelles and polymer blends. (authors)

Elucidating the interplay between DNA-condensing and free polycations in gene transfection through a mechanistic study of linear and branched PEI

DEFF Research Database (Denmark)

Dai, Zhuojun; Gjetting, Torben; Mattebjerg, Maria Ahlm

2011-01-01

In the present study we compare LPEI and BPEI characteristics related to DNA condensation and their role as free polycation chains in gene transfection. Using radioactive 32P labeled DNA, we investigated the effect of free PEI chains on the cellular uptake of polyplexes. Our investigations show d...

76 FR 45693 - Safety Zone; San Diego POPS Fireworks, San Diego, CA

Science.gov (United States)

2011-08-01

...-AA00 Safety Zone; San Diego POPS Fireworks, San Diego, CA AGENCY: Coast Guard, DHS. ACTION: Temporary... San Diego Bay in support of the San Diego POPS Fireworks. This safety zone is necessary to provide for... of the waterway during scheduled fireworks events. Persons and vessels will be prohibited from...

33 CFR 165.754 - Safety Zone: San Juan Harbor, San Juan, PR.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone: San Juan Harbor, San Juan, PR. 165.754 Section 165.754 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Zone: San Juan Harbor, San Juan, PR. (a) Regulated area. A moving safety zone is established in the...

The prevalence of small intestinal bacterial overgrowth in non-surgical patients with chronic pancreatitis and pancreatic exocrine insufficiency (PEI).

Science.gov (United States)

Ní Chonchubhair, Hazel M; Bashir, Yasir; Dobson, Mark; Ryan, Barbara M; Duggan, Sinead N; Conlon, Kevin C

2018-02-24

Small intestinal bacterial overgrowth (SIBO) is a condition characterised by symptoms similar to pancreatic exocrine insufficiency (PEI) in chronic pancreatitis patients. SIBO is thought to complicate chronic pancreatitis in up to 92% of cases; however, studies are heterogeneous and protocols non-standardised. SIBO may be determined by measuring lung air-expiration of either hydrogen or methane which are by-products of small bowel bacterial fermentation of intraluminal substrates such as carbohydrates. We evaluated the prevalence of SIBO among a defined cohort of non-surgical chronic pancreatitics with mild to severe PEI compared with matched healthy controls. Thirty-five patients and 31 age-, gender- and smoking status-matched healthy controls were evaluated for SIBO by means of a fasting glucose hydrogen breath test (GHBT). The relationship between SIBO and clinical symptoms in chronic pancreatitis was evaluated. SIBO was present in 15% of chronic pancreatitis patients, while no healthy controls tested positive (P = 0.029). SIBO was more prevalent in those taking pancreatic enzyme replacement therapy (PERT) (P = 0.016), with proton pump inhibitor use (PPI) (P = 0.022) and in those with alcohol aetiology (P = 0.023). Patients with concurrent diabetes were more often SIBO-positive and this was statistically significant (P = 0.009). There were no statistically significant differences in reported symptoms between patients with and without SIBO, with the exception of 'weight loss', with patients reporting weight loss more likely to have SIBO (P = 0.047). The prevalence of SIBO in this study was almost 15% and consistent with other studies of SIBO in non-surgical chronic pancreatitis patients. These data support the testing of patients with clinically-relevant PEI unresolved by adequate doses of PERT, particularly in those patients with concurrent diabetes. SIBO can be easily diagnosed therefore allowing more specific and more targeted symptom

[Textual research on circulation of the Ming edition of Li Heng's Xiu zhen fang (Pocket Formulary)].

Science.gov (United States)

Yang, Jinping; Liu, Peng; Lu, Mingjing; Lu, Xing; Li, Shaolin; Jin, Xiumei

2015-03-01

Xiu zhen fang (Pocket Formulary) is a recipe book of the Ming Dynasty, inspired and managed by Zhu Su, compiled by Li Heng of liangyisuo (good physician house) in Zhou wangfu (Zhou's royal palace). The book was compiled and published twice during the reigns of the Hongwu and Yongle Emperors of the Ming Dynasty. Because of its high practicability, there were some editions in circulation, and the book was published several times only in the Ming Dynasty. At present, the earliest extanteditionwas the little character version of Yongle, and the version in the 4(th) year of Zhengde Emperor of the Ming Dynasty was a reprinting edition based on the Yongle edition, sharingthe same edition system. Most of the editions appeared after the reign of Zhengtong Emperor of the Ming Dynasty, titled by "kui ben (head version)" and "da quan (complete edition)" were the editionspublished in the local bookshops, which had rather distinct differences from the Yongle edition system not only in the its format but also in its contents.

Minería, conflicto y mediadores locales: Minera San Xavier en Cerro de San Pedro, México Mineira, conflito e mediadores locais: Minera San Xavier em Cerro de San Pedro Mining, conflict and local brokers: Minera San Xavier in Cerro de San Pedro

Directory of Open Access Journals (Sweden)

Hernán Horacio Schiaffini

2011-12-01

Full Text Available Este trabajo indaga en las instancias de mediación que intervienen en la articulación de procesos económicos de gran escala y su puesta en práctica local. Basándonos en el conflicto que se produjo en el Municipio de Cerro de San Pedro (San Luis Potosí, México entre la empresa Minera San Xavier y el Frente Amplio Opositor (FAO a la misma, aplicamos el método etnográfico con el objetivo de describir las estructuras locales de mediación política y analizar sus prácticas y racionalidad. Intentamos demostrar así la importancia de los factores políticos locales en las vinculaciones entre estado, empresa y población.Este trabalho indaga nas instâncias de mediação que intervêm em processos econômicos de grande escala e sua posta em prática local. Baseando-nos no conflito no Cerro de San Pedro (San Luis Potosí, México entre a empresa Minera San Xavier e a Frente Amplio Opositor (FAO aplicamos o método etnográfico pra descrever as estruturas de mediação política locais e analisar suas práticas e racionalidade. Tenta-se demonstrar assim a importância dos fatores políticos locais nas vinculações entre estado, empresa e população.This paper investigates in instances of mediation involved in large-scale economic processes and local implementation. Analyzing the conflict in Cerro de San Pedro (San Luis Potosí, México among San Xavier mining company and the Frente Amplio Opositor (FAO, it applies an ethnographic approach to describe the local structures of political mediation and its practices and rationality. The work shows the relevance of local factors in the relationships between State, company and people.

Long-term results of interventional treatment of large unresectable hepatocellular carcinoma (HCC): significant survival benefit from combined transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) compared to TACE monotherapy

International Nuclear Information System (INIS)

Lubienski, A.; Bitsch, R.G.; Grenacher, L.; Kauffmann, G.W.; Schemmer, P.; Duex, M.

2004-01-01

Purpose: A retrospective analysis of long-term efficacy of combined transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) and TACE monotherapy was conducted in patients with large, non-resectable hepatocellular carcinoma (HCC). Methods and Materials: Fifty patients with large, unresectable HCC lesions underwent selective TACE. Liver cirrhosis was present in 42 patients, due to alcohol abuse (n = 22) and viral infection (n = 17). In three patients, the underlying cause for liver cirrhosis remained unclear. Child A cirrhosis was found in 22 and Child B cirrhosis in 20 patients. Repeated and combined TACE and PEI were performed in 22 patients and repeated TACE monotherapy was performed in 28 patients. Survival and complication rates were determined and compared. Results: The 6-, 12-, 24- and 36-month survival rates were 61%, 21%, 4%, and 4% for TACE monotherapy and 77%, 55%, 39% and 22% for combined TACE and PEI (Kaplan-Meier method). The kind of treatment significantly affected the survival rate (p=0.002 log-rank test). Severe side effects were present in two patients of the monotherapy group and in three patients of the combination therapy group. (orig.)

Ergonomic Analysis of UI’s BicyclesUsing Posture Evaluation Index (PEI Method in Virtual Environment

Directory of Open Access Journals (Sweden)

Erlinda Muslim

2010-10-01

Full Text Available This research was conducted to study ergonomic aspect from University of Indonesia bicycle in virtual environment. Software Jack 6.0 was used to analyze it. PEI was used as approach that integrated the results of three methods: Lower Back Analysis, Ovako Working Posture Analysis, and Rapid Upper Limb Assessment. The research objective is to evaluate existing design of University of Indonesia bicycle and to determine the most ergonomic redesign which concern with handlebar height and saddle height modification. The result showed that the most ergonomic design of University of Indonesia bicycle is the one with the highest handlebar height (22 cm and the lowest saddle height (11 cm.

76 FR 1386 - Safety Zone; Centennial of Naval Aviation Kickoff, San Diego Bay, San Diego, CA

Science.gov (United States)

2011-01-10

...-AA00 Safety Zone; Centennial of Naval Aviation Kickoff, San Diego Bay, San Diego, CA AGENCY: Coast... zone on the navigable waters of San Diego Bay in San Diego, CA in support of the Centennial of Naval... February 12, 2010, the Centennial of Naval Aviation Kickoff will take place in San Diego Bay. In support of...

San Marino.

Science.gov (United States)

1985-02-01

San Marino, an independent republic located in north central Italy, in 1983 had a population of 22,206 growing at an annual rate of .9%. The literacy rate is 97% and the infant mortality rate is 9.6/1000. The terrain is mountainous and the climate is moderate. According to local tradition, San Marino was founded by a Christian stonecutter in the 4th century A.D. as a refuge against religious persecution. Its recorded history began in the 9th century, and it has survived assaults on its independence by the papacy, the Malatesta lords of Rimini, Cesare Borgia, Napoleon, and Mussolini. An 1862 treaty with the newly formed Kingdom of Italy has been periodically renewed and amended. The present government is an alliance between the socialists and communists. San Marino has had its own statutes and governmental institutions since the 11th century. Legislative authority at present is vested in a 60-member unicameral parliament. Executive authority is exercised by the 11-member Congress of State, the members of which head the various administrative departments of the goverment. The posts are divided among the parties which form the coalition government. Judicial authority is partly exercised by Italian magistrates in civil and criminal cases. San Marino's policies are tied to Italy's and political organizations and labor unions active in Italy are also active in San Marino. Since World War II, there has been intense rivalry between 2 political coalitions, the Popular Alliance composed of the Christian Democratic Party and the Independent Social Democratic Party, and the Liberty Committee, coalition of the Communist Party and the Socialist Party. San Marino's gross domestic product was $137 million and its per capita income was $6290 in 1980. The principal economic activities are farming and livestock raising, along with some light manufacturing. Foreign transactions are dominated by tourism. The government derives most of its revenue from the sale of postage stamps to

San Francisco District Laboratory (SAN)

Data.gov (United States)

Federal Laboratory Consortium — Program CapabilitiesFood Analysis SAN-DO Laboratory has an expert in elemental analysis who frequently performs field inspections of materials. A recently acquired...

76 FR 9709 - Water Quality Challenges in the San Francisco Bay/Sacramento-San Joaquin Delta Estuary

Science.gov (United States)

2011-02-22

... Water Quality Challenges in the San Francisco Bay/Sacramento-San Joaquin Delta Estuary AGENCY... the San Francisco Bay/ Sacramento-San Joaquin Delta Estuary (Bay Delta Estuary) in California. EPA is... programs to address recent significant declines in multiple aquatic species in the Bay Delta Estuary. EPA...

33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico 165.776 Section 165.776 Navigation and Navigable Waters COAST... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico (a...

Highly efficient inverted organic light emitting diodes by inserting a zinc oxide/polyethyleneimine (ZnO:PEI) nano-composite interfacial layer

Science.gov (United States)

Kaçar, Rifat; Pıravadılı Mucur, Selin; Yıldız, Fikret; Dabak, Salih; Tekin, Emine

2017-06-01

The electrode/organic interface is one of the key factors in attaining superior device performance in organic electronics, and inserting a tailor-made layer can dramatically modify its properties. The use of nano-composite (NC) materials leads to many advantages by combining materials with the objective of obtaining a desirable combination of properties. In this context, zinc oxide/polyethyleneimine (ZnO:PEI) NC film was incorporated as an interfacial layer into inverted bottom-emission organic light emitting diodes (IBOLEDs) and fully optimized. For orange-red emissive MEH-PPV based IBOLEDs, a high power efficiency of 6.1 lm W-1 at a luminance of 1000 cd m-2 has been achieved. Notably, the external quantum efficiency (EQE) increased from 0.1 to 4.8% and the current efficiency (CE) increased from 0.2 to 8.7 cd A-1 with rise in luminance (L) from 1000 to above 10 000 cd m-2 levels when compared to that of pristine ZnO-based devices. An identical device architecture containing a ZnO:PEI NC layer has also been used to successfully fabricate green and blue emissive IBOLEDs. The significant enhancement in the inverted device performance, in terms of luminance and efficiency, is attributed to a good energy-level alignment between the cathode/organic interface which leads to effective carrier balance, resulting in efficient radiative-recombination.

Enhanced Preliminary Assessment Report: Presidio of San Francisco Military Reservation, San Francisco, California

Science.gov (United States)

1989-11-01

CAD981415656 Filmore Steiner Bay San Francisco 24 PG&E Gas Plant SanFran 502-IG CAD981415714 Bay North Point Buchanan Laguna 25 PG&E Gas Plant SanFran 502-1H...76-ioV /5,JO /0.7 /,230 PSF Water PSF, Main U.N. Lagunda Honda Analvte Plant Clearwell Reservoir Plaza Reservoi- Chlordane inetab. ə.2 ə.2 (1.2 ə.2

A case for historic joint rupture of the San Andreas and San Jacinto faults.

Science.gov (United States)

Lozos, Julian C

2016-03-01

The San Andreas fault is considered to be the primary plate boundary fault in southern California and the most likely fault to produce a major earthquake. I use dynamic rupture modeling to show that the San Jacinto fault is capable of rupturing along with the San Andreas in a single earthquake, and interpret these results along with existing paleoseismic data and historic damage reports to suggest that this has likely occurred in the historic past. In particular, I find that paleoseismic data and historic observations for the ~M7.5 earthquake of 8 December 1812 are best explained by a rupture that begins on the San Jacinto fault and propagates onto the San Andreas fault. This precedent carries the implications that similar joint ruptures are possible in the future and that the San Jacinto fault plays a more significant role in seismic hazard in southern California than previously considered. My work also shows how physics-based modeling can be used for interpreting paleoseismic data sets and understanding prehistoric fault behavior.

A case for historic joint rupture of the San Andreas and San Jacinto faults

Science.gov (United States)

Lozos, Julian C.

2016-01-01

The San Andreas fault is considered to be the primary plate boundary fault in southern California and the most likely fault to produce a major earthquake. I use dynamic rupture modeling to show that the San Jacinto fault is capable of rupturing along with the San Andreas in a single earthquake, and interpret these results along with existing paleoseismic data and historic damage reports to suggest that this has likely occurred in the historic past. In particular, I find that paleoseismic data and historic observations for the ~M7.5 earthquake of 8 December 1812 are best explained by a rupture that begins on the San Jacinto fault and propagates onto the San Andreas fault. This precedent carries the implications that similar joint ruptures are possible in the future and that the San Jacinto fault plays a more significant role in seismic hazard in southern California than previously considered. My work also shows how physics-based modeling can be used for interpreting paleoseismic data sets and understanding prehistoric fault behavior. PMID:27034977

76 FR 10945 - San Luis Trust Bank, FSB, San Luis Obispo, CA; Notice of Appointment of Receiver

Science.gov (United States)

2011-02-28

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision San Luis Trust Bank, FSB, San Luis Obispo, CA; Notice of Appointment of Receiver Notice is hereby given that, pursuant to the authority... appointed the Federal Deposit Insurance Corporation as sole Receiver for San Luis Trust Bank, FSB, San Luis...

76 FR 22809 - Safety Zone; Bay Ferry II Maritime Security Exercise; San Francisco Bay, San Francisco, CA

Science.gov (United States)

2011-04-25

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2011-0196] RIN 1625-AA00 Safety Zone; Bay Ferry II Maritime Security Exercise; San Francisco Bay, San Francisco, CA AGENCY... Security Exercise; San Francisco Bay, San Francisco, CA. (a) Location. The limits of this safety zone...

The San Bernabe power substation; La subestacion San Bernabe

Energy Technology Data Exchange (ETDEWEB)

Chavez Sanudo, Andres D. [Luz y Fuerza del Centro, Mexico, D. F. (Mexico)

1997-12-31

The first planning studies that gave rise to the San Bernabe substation go back to year 1985. The main circumstance that supports this decision is the gradual restriction for electric power generation that has been suffering the Miguel Aleman Hydro System, until its complete disappearance, to give priority to the potable water supply through the Cutzamala pumping system, that feeds in an important way Mexico City and the State of Mexico. In this document the author describes the construction project of the San Bernabe Substation; mention is made of the technological experiences obtained during the construction and its geographical location is shown, as well as the one line diagram of the same [Espanol] Los primeros estudios de planeacion que dieron origen a la subestacion San Bernabe se remontan al ano de 1985. La circunstancia principal que soporta esta decision es la restriccion paulatina para generar energia que ha venido experimentando el Sistema Hidroelectrico Miguel Aleman, hasta su desaparicion total, para dar prioridad al suministro de agua potable por medio del sistema de bombeo Cutzamala, que alimenta en forma importante a la Ciudad de Mexico y al Estado de Mexico. En este documento el autor describe el proyecto de construccion de la subestacion San Bernabe; se mencionan las experiencias tecnologicas obtenidas durante su construccion y se ilustra su ubicacion geografica, asi como un diagrama unifilar de la misma

Description of gravity cores from San Pablo Bay and Carquinez Strait, San Francisco Bay, California

Science.gov (United States)

Woodrow, Donald L.; John L. Chin,; Wong, Florence L.; Fregoso, Theresa A.; Jaffe, Bruce E.

2017-06-27

Seventy-two gravity cores were collected by the U.S. Geological Survey in 1990, 1991, and 2000 from San Pablo Bay and Carquinez Strait, California. The gravity cores collected within San Pablo Bay contain bioturbated laminated silts and sandy clays, whole and broken bivalve shells (mostly mussels), fossil tube structures, and fine-grained plant or wood fragments. Gravity cores from the channel wall of Carquinez Strait east of San Pablo Bay consist of sand and clay layers, whole and broken bivalve shells (less than in San Pablo Bay), trace fossil tubes, and minute fragments of plant material.

78 FR 34123 - Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA

Science.gov (United States)

2013-06-06

... completion of an inventory of human remains and associated funerary objects under the control of the San....R50000] Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA... NAGPRA Program has completed an inventory of human remains and associated funerary objects, in...

78 FR 21403 - Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA

Science.gov (United States)

2013-04-10

... completion of an inventory of human remains and associated funerary objects under the control of the San....R50000] Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA... NAGPRA Program has completed an inventory of human remains and associated funerary objects, in...

75 FR 15611 - Safety Zone; United Portuguese SES Centennial Festa, San Diego Bay, San Diego, CA

Science.gov (United States)

2010-03-30

...-AA00 Safety Zone; United Portuguese SES Centennial Festa, San Diego Bay, San Diego, CA AGENCY: Coast... navigable waters of the San Diego Bay in support of the United Portuguese SES Centennial Festa. This... Centennial Festa, which will include a fireworks presentation originating from a tug and barge combination in...

Performance of BATAN-SANS instrument

Energy Technology Data Exchange (ETDEWEB)

Ikram, Abarrul; Insani, Andon [National Nuclear Energy Agency, P and D Centre for Materials Science and Technology, Serpong (Indonesia)

2003-03-01

SANS data from some standard samples have been obtained using BATAN-SANS instrument in Serpong. The experiments were performed for various experimental set-ups that involve different detector positions and collimator lengths. This paper describes the BATAN-SANS instrument briefly as well as the data taken from those experiments and followed with discussion of the results concerning the performance and calibration of the instrument. The standard samples utilized in these experiments include porous silica, polystyrene-poly isoprene, silver behenate, poly ball and polystyrene-poly (ethylene-alt-propylene). Even though the results show that BATAN-SANS instrument is in good shape, but rooms for improvements are still widely open especially for the velocity selector and its control system. (author)

A case for historic joint rupture of the San Andreas and San Jacinto faults

OpenAIRE

Lozos, Julian C.

2016-01-01

The San Andreas fault is considered to be the primary plate boundary fault in southern California and the most likely fault to produce a major earthquake. I use dynamic rupture modeling to show that the San Jacinto fault is capable of rupturing along with the San Andreas in a single earthquake, and interpret these results along with existing paleoseismic data and historic damage reports to suggest that this has likely occurred in the historic past. In particular, I find that paleoseismic data...

TWO NEW RECORDS OF Isomyia paurogonita FANG AND FAN, 1986 AND Sumatria latifrons Malloch, 1926 (DIPTERA: CALLIPHORIDAE FROM NORTHERN THAILAND, WITH REVISED KEY TO THE SPECIES OF Isomyia

Directory of Open Access Journals (Sweden)

Nophawan Bunchu

2014-04-01

Full Text Available During the annual fly survey at Doi Nang Kaew in Doi Saket District, Chiang Mai Province of Thailand in 2011, Isomyia paurogonita Fang & Fan, 1986 (Diptera: Calliphoridae and Sumatria latifrons Malloch, 1926 (Diptera: Calliphoridae were collected for the first time in Thailand. They are the rare species of the subfamily Rhiniinae (tribe Cosminini. Prior to this finding, fifteen species of Isomyia and two species of Sumatria were recorded from Thailand. Therefore, 96 blow fly species have been found in this country. These new locality records of both flies are very important for further research on their biology and ecology in Thailand.

San Marco C-2 (San Marco-4) Post Launch Report No. 1

Science.gov (United States)

1974-01-01

The San Marco C-2 spacecraft, now designated San Marco-4, was successfully launched by a Scout vehicle from the San Marco Platform on 18 February 1974 at 6:05 a.m. EDT. The launch occurred 2 hours 50 minutes into the 3-hour window due co low cloud cover at the launch site. All spacecraft subsystems have been checked and are functioning normally. The protective caps for the two U.S. experiments were ejected and the Omegatron experiment activated on 19 February. The neutral mass spectrometer was activated as scheduled on 22 February after sufficient time to allow for spacecraft outgassing and to avoid the possibility of corona occurring. Both instruments are performing properly and worthwhile scientific data is being acquired.

77 FR 34988 - Notice of Inventory Completion: San Diego State University, San Diego, CA

Science.gov (United States)

2012-06-12

.... ACTION: Notice. SUMMARY: San Diego State University Archeology Collections Management Program has... that believes itself to be culturally affiliated with the human remains and associated funerary objects may contact San Diego State University Archeology Collections Management Program. Repatriation of the...

78 FR 53243 - Safety Zone; TriRock San Diego, San Diego Bay, San Diego, CA

Science.gov (United States)

2013-08-29

... this rule because the logistical details of the San Diego Bay triathlon swim were not finalized nor... September 22, 2013. (c) Definitions. The following definition applies to this section: Designated...

77 FR 59969 - Notice of Inventory Completion: San Francisco State University, Department of Anthropology, San...

Science.gov (United States)

2012-10-01

... Inventory Completion: San Francisco State University, Department of Anthropology, San Francisco, CA... Francisco State University, NAGPRA Program (formerly in the Department of Anthropology). The human remains... State University Department of Anthropology records. In the Federal Register (73 FR 30156-30158, May 23...

33 CFR 165.1182 - Safety/Security Zone: San Francisco Bay, San Pablo Bay, Carquinez Strait, and Suisun Bay, CA.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety/Security Zone: San... Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY... Areas Eleventh Coast Guard District § 165.1182 Safety/Security Zone: San Francisco Bay, San Pablo Bay...

SAN MICHELE. ENTRE CIELO Y MAR / San Michele, between sky and sea

Directory of Open Access Journals (Sweden)

Pablo Blázquez Jesús

2012-11-01

Full Text Available RESUMEN El cementerio es uno de los tipos arquitectónicos más profundos y metafóricos. El concurso para la ampliación del cementerio de San Michele, convocado en 1998 por la administración Municipal de Venecia, se convierte en un excelente campo de pruebas sobre el que poder analizar el contexto histórico en torno a esta tipología, y su relación con la ciudad y el territorio. El estudio de este caso concreto nos permite descubrir personajes, relaciones casuales y hallazgos que se despliegan a lo largo del texto. La historia del cementerio de San Michele es también la crónica de la transformación de la ciudad de Venecia y su Laguna. Interpretando este concurso como un instrumento de investigación, el objetivo del artículo es el de comprender la realidad contemporánea de la arquitectura funeraria a través de la isla de San Michele, Venecia, y las propuestas finalistas de Carlos Ferrater, Enric Miralles y David Chipperfield. Una historia bajo la cual se vislumbran claves que nos sirven para reflexionar acerca del cementerio contemporáneo, la ciudad y el territorio. SUMMARY The cemetery is one of the most profound and metaphorical kinds of architecture. The competition for the extension of the San Michele Cemetery, called in 1998 by the Venice municipal administration, is an excellent testing ground on which to analyse the historical context surrounding this type of architecture, and its relationship with the city and the region. The study of this particular case allows us to uncover characters, casual relationships and findings that unfold throughout the text. The history of the San Michele cemetery is also the chronicle of the transformation of the city of Venice and its Lagoon. Interpreting this competition as a research tool, the aim of the paper is to understand the contemporary reality of funerary architecture through the island of San Michele, Venice, and the finalist proposals of Carlos Ferrater, Enric Miralles and David

Pleistocene Brawley and Ocotillo Formations: Evidence for initial strike-slip deformation along the San Felipe and San Jacinto fault zonez, Southern California

Science.gov (United States)

Kirby, S.M.; Janecke, S.U.; Dorsey, R.J.; Housen, B.A.; Langenheim, V.E.; McDougall, K.A.; Steeley, A.N.

2007-01-01

We examine the Pleistocene tectonic reorganization of the Pacific-North American plate boundary in the Salton Trough of southern California with an integrated approach that includes basin analysis, magnetostratigraphy, and geologic mapping of upper Pliocene to Pleistocene sedimentary rocks in the San Felipe Hills. These deposits preserve the earliest sedimentary record of movement on the San Felipe and San Jacinto fault zones that replaced and deactivated the late Cenozoic West Salton detachment fault. Sandstone and mudstone of the Brawley Formation accumulated between ???1.1 and ???0.6-0.5 Ma in a delta on the margin of an arid Pleistocene lake, which received sediment from alluvial fans of the Ocotillo Formation to the west-southwest. Our analysis indicates that the Ocotillo and Brawley formations prograded abruptly to the east-northeast across a former mud-dominated perennial lake (Borrego Formation) at ???1.1 Ma in response to initiation of the dextral-oblique San Felipe fault zone. The ???25-km-long San Felipe anticline initiated at about the same time and produced an intrabasinal basement-cored high within the San Felipe-Borrego basin that is recorded by progressive unconformities on its north and south limbs. A disconformity at the base of the Brawley Formation in the eastern San Felipe Hills probably records initiation and early blind slip at the southeast tip of the Clark strand of the San Jacinto fault zone. Our data are consistent with abrupt and nearly synchronous inception of the San Jacinto and San Felipe fault zones southwest of the southern San Andreas fault in the early Pleistocene during a pronounced southwestward broadening of the San Andreas fault zone. The current contractional geometry of the San Jacinto fault zone developed after ???0.5-0.6 Ma during a second, less significant change in structural style. ?? 2007 by The University of Chicago. All rights reserved.

Vegetation - San Felipe Valley [ds172

Data.gov (United States)

California Natural Resource Agency — This Vegetation Map of the San Felipe Valley Wildlife Area in San Diego County, California is based on vegetation samples collected in the field in 2002 and 2005 and...

Two-Sided Surface Oxidized Cellulose Membranes Modified with PEI: Preparation, Characterization and Application for Dyes Removal

Directory of Open Access Journals (Sweden)

Wei Wang

2017-09-01

Full Text Available Porous regenerated cellulose (RC membranes were prepared with cotton linter pulp as a raw material. These membranes were first oxidized on both sides by a modified (2,2,6,6-tetramethylpiperidin-1-yloxyl (TEMPO oxidation system using a controlled oxidation reaction technique. Then, the oxidized RC membranes were functionalized with polyethylenimine (PEI via the glutaraldehyde crosslinking method to obtain bifunctional (carboxyl and amino porous RC membranes, as revealed by Fourier transform infrared spectroscopy (FT-IR, elemental analysis and zeta potential measurement. The scanning electron microscopy (SEM and the tests of the mechanical properties and permeability characteristics of modified RC membranes demonstrated that the porous structure and certain mechanical properties could be retained. The adsorption performance of the modified membranes towards dyes was subsequently investigated. The modified membranes displayed good adsorption capacities, rapid adsorption equilibrium and removal efficiencies towards both anionic (xylenol orange (XO and cationic (methylene blue (MB dyes, making them suitable bioadsorbents for wastewater treatment.

El urbanismo de Santiago de Compostela : un plano con las plazuelas de San Martín y de San Miguel de 1709

Directory of Open Access Journals (Sweden)

Miguel Taín Guzmán

1998-01-01

Full Text Available El presente artículo está dedicado al estudio de un plano inédito de 1709 donde se representan las plazuelas de San Martín y de San Miguel, en el barrio intramuros de la Puerta de la Peña de Santiago de Compostela. Gracias al referido dibujo, analizo al detalle el entramado urbano de ambos espacios públicos y los edificios que los delimitan, particularmente la iglesia de San Martín Pinario, el desaparecido Palacio del Tribunal de la Santa Inquisición y la iglesia parroquial de San Miguel dos Agros.The article focuses on the study of a 1709 inpublished street plan of two squares —San Martín and San Miguel— in the Puerta de la Peña quarter (Santiago de Compostela. This oíd drawing shows the urban framework of both public spaces and also the buildings around: San Martín Pinario, the lost Palacio del Tribunal de la Santa Inquisición and the paroquial church of San Miguel de los Agros.

78 FR 57482 - Safety Zone; America's Cup Aerobatic Box, San Francisco Bay, San Francisco, CA

Science.gov (United States)

2013-09-19

...-AA00 Safety Zone; America's Cup Aerobatic Box, San Francisco Bay, San Francisco, CA AGENCY: Coast Guard... America's Cup air shows. These safety zones are established to provide a clear area on the water for... announced by America's Cup Race Management. ADDRESSES: Documents mentioned in this preamble are part of...

77 FR 42649 - Safety Zone: Sea World San Diego Fireworks, Mission Bay; San Diego, CA

Science.gov (United States)

2012-07-20

... 1625-AA00 Safety Zone: Sea World San Diego Fireworks, Mission Bay; San Diego, CA AGENCY: Coast Guard... authorized by the Captain of the Port, or his designated representative. DATES: This rule is effective from 8... to ensure the public's safety. B. Basis and Purpose The Ports and Waterways Safety Act gives the...

Cataclastic rocks of the San Gabriel fault—an expression of deformation at deeper crustal levels in the San Andreas fault zone

Science.gov (United States)

Anderson, J. Lawford; Osborne, Robert H.; Palmer, Donald F.

1983-10-01

The San Gabriel fault, a deeply eroded late Oligocene to middle Pliocene precursor to the San Andreas, was chosen for petrologic study to provide information regarding intrafault material representative of deeper crustal levels. Cataclastic rocks exposed along the present trace of the San Andreas in this area are exclusively a variety of fault gouge that is essentially a rock flour with a quartz, feldspar, biotite, chlorite, amphibole, epidote, and Fe-Ti oxide mineralogy representing the milled-down equivalent of the original rock (Anderson and Osborne, 1979; Anderson et al., 1980). Likewise, fault gouge and associated breccia are common along the San Gabriel fault, but only where the zone of cataclasis is several tens of meters wide. At several localities, the zone is extremely narrow (several centimeters), and the cataclastic rock type is cataclasite, a dark, aphanitic, and highly comminuted and indurated rock. The cataclastic rocks along the San Gabriel fault exhibit more comminution than that observed for gouge along the San Andreas. The average grain diameter for the San Andreas gouge ranges from 0.01 to 0.06 mm. For the San Gabriel cataclastic rocks, it ranges from 0.0001 to 0.007 mm. Whereas the San Andreas gouge remains particulate to the smallest grain-size, the ultra-fine grain matrix of the San Gabriel cataclasite is composed of a mosaic of equidimensional, interlocking grains. The cataclastic rocks along the San Gabriel fault also show more mineralogiec changes compared to gouge from the San Andreas fault. At the expense of biotite, amphibole, and feldspar, there is some growth of new albite, chlorite, sericite, laumontite, analcime, mordenite (?), and calcite. The highest grade of metamorphism is laumontite-chlorite zone (zeolite facies). Mineral assemblages and constrained uplift rates allow temperature and depth estimates of 200 ± 30° C and 2-5 km, thus suggesting an approximate geothermal gradient of ~50°C/km. Such elevated temperatures imply a

The disappearing San of southeastern Africa and their genetic affinities.

Science.gov (United States)

Schlebusch, Carina M; Prins, Frans; Lombard, Marlize; Jakobsson, Mattias; Soodyall, Himla

2016-12-01

Southern Africa was likely exclusively inhabited by San hunter-gatherers before ~2000 years ago. Around that time, East African groups assimilated with local San groups and gave rise to the Khoekhoe herders. Subsequently, Bantu-speaking farmers, arriving from the north (~1800 years ago), assimilated and displaced San and Khoekhoe groups, a process that intensified with the arrival of European colonists ~350 years ago. In contrast to the western parts of southern Africa, where several Khoe-San groups still live today, the eastern parts are largely populated by Bantu speakers and individuals of non-African descent. Only a few scattered groups with oral traditions of Khoe-San ancestry remain. Advances in genetic research open up new ways to understand the population history of southeastern Africa. We investigate the genomic variation of the remaining individuals from two South African groups with oral histories connecting them to eastern San groups, i.e., the San from Lake Chrissie and the Duma San of the uKhahlamba-Drakensberg. Using ~2.2 million genetic markers, combined with comparative published data sets, we show that the Lake Chrissie San have genetic ancestry from both Khoe-San (likely the ||Xegwi San) and Bantu speakers. Specifically, we found that the Lake Chrissie San are closely related to the current southern San groups (i.e., the Karretjie people). Duma San individuals, on the other hand, were genetically similar to southeastern Bantu speakers from South Africa. This study illustrates how genetic tools can be used to assess hypotheses about the ancestry of people who seemingly lost their historic roots, only recalling a vague oral tradition of their origin.

75 FR 27432 - Security Zone; Golden Guardian 2010 Regional Exercise; San Francisco Bay, San Francisco, CA

Science.gov (United States)

2010-05-17

... can better evaluate its effects on them and participate in the rulemaking process. Small businesses... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2010-0221] RIN 1625-AA87 Security Zone; Golden Guardian 2010 Regional Exercise; San Francisco Bay, San Francisco, CA AGENCY...

Toxic phytoplankton in San Francisco Bay

Science.gov (United States)

Rodgers, Kristine M.; Garrison, David L.; Cloern, James E.

1996-01-01

The Regional Monitoring Program (RMP) was conceived and designed to document the changing distribution and effects of trace substances in San Francisco Bay, with focus on toxic contaminants that have become enriched by human inputs. However, coastal ecosystems like San Francisco Bay also have potential sources of naturally-produced toxic substances that can disrupt food webs and, under extreme circumstances, become threats to public health. The most prevalent source of natural toxins is from blooms of algal species that can synthesize metabolites that are toxic to invertebrates or vertebrates. Although San Francisco Bay is nutrient-rich, it has so far apparently been immune from the epidemic of harmful algal blooms in the world’s nutrient-enriched coastal waters. This absence of acute harmful blooms does not imply that San Francisco Bay has unique features that preclude toxic blooms. No sampling program has been implemented to document the occurrence of toxin-producing algae in San Francisco Bay, so it is difficult to judge the likelihood of such events in the future. This issue is directly relevant to the goals of RMP because harmful species of phytoplankton have the potential to disrupt ecosystem processes that support animal populations, cause severe illness or death in humans, and confound the outcomes of toxicity bioassays such as those included in the RMP. Our purpose here is to utilize existing data on the phytoplankton community of San Francisco Bay to provide a provisional statement about the occurrence, distribution, and potential threats of harmful algae in this Estuary.

ASTER Flyby of San Francisco

Science.gov (United States)

2002-01-01

The Advanced Spaceborne Thermal Emission and Reflection radiometer, ASTER, is an international project: the instrument was supplied by Japan's Ministry of International Trade and Industry. A joint US/Japan science team developed algorithms for science data products, and is validating instrument performance. With its 14 spectral bands, extremely high spatial resolution, and 15 meter along-track stereo capability, ASTER is the zoom lens of the Terra satellite. The primary mission goals are to characterize the Earth's surface; and to monitor dynamic events and processes that influence habitability at human scales. ASTER's monitoring and mapping capabilities are illustrated by this series of images of the San Francisco area. The visible and near infrared image reveals suspended sediment in the bays, vegetation health, and details of the urban environment. Flying over San Francisco (3.2MB) (high-res (18.3MB)), we see the downtown, and shadows of the large buildings. Past the Golden Gate Bridge and Alcatraz Island, we cross San Pablo Bay and enter Suisun Bay. Turning south, we fly over the Berkeley and Oakland Hills. Large salt evaporation ponds come into view at the south end of San Francisco Bay. We turn northward, and approach San Francisco Airport. Rather than landing and ending our flight, we see this is as only the beginning of a 6 year mission to better understand the habitability of the world on which we live. For more information: ASTER images through Visible Earth ASTER Web Site Image courtesy of MITI, ERSDAC, JAROS, and the U.S./Japan ASTER Science Team

The Effect of Bangpungtongsung-san Extracts on Adipocyte Metabolism

Directory of Open Access Journals (Sweden)

Sang Min, Lee

2008-03-01

Full Text Available Objective : The purpose of this study is to investigate the effects of Bangpungtongsung-san extracts on the preadipocytes proliferation, of 3T3-L1 cell line. lipolysis of adipocytes in rat's epididymis and localized fat accumulation of porcine by extraction methods(alcohol and water. Methods : Diminish 3T3-L1 proliferation and lipogenesis do primary role to reduce obesity. So, 3T3-L1 preadipocyte and adipocytes were performed on cell cultures, and using Sprague-Dawley rats for the lipogenesis, and treated with 0.01-1 ㎎/㎖ Bangpungtongsung-san Extracts depend on concentrations. Porcine skin including fat tissue after treated Bangpungtongsung-san Extracts by means of the dosage dependent variation are investigated the histologic changes after injection of these extracts. Results : Following results were obtained from the 3T3-L1 preadipocyte proliferation and lipolysis of adipocyte in rats and histologic investigation of fat tissue. 1. Bangpungtongsung-san extracts were showed the effect of decreased preadipocyte proliferation on the high dosage(1.0㎎/㎖. 2. Bangpungtongsung-san extracts were showed the effect of decreased the activity of glycerol-3-phosphate dehydrogenase(GPDH on the high dosage(1.0㎎/㎖ and Specially, alcohol extract of Bangpungtongsung -san was clear as time goes by high concentration. 3. Bangpungtongsung-san extracts were showed tries to compare the effect of lipolysis, alcohol extract of Bangpungtongsung-san on the high dosage(1.0㎎/㎖ was observed the effect is higher than water extract. 4. Investigated the histological changes in porcine fat tissue after treated Bangpungtongsung-san extracts, we knew that water extract of Bangpungtongsung-san was showed the effect of lipolysis on the high dosage(10.0㎎/㎖ and alcohol extract of Bangpungtongsung-san was showed significant activity to the lysis of cell membranes in all concentration. Conclusion : These results suggest that Bangpungtongsung-san extracts efficiently

SANS studies of polymers

International Nuclear Information System (INIS)

Wignall, G.D.

1984-10-01

Before small-angle neutron scattering (SANS), chain conformation studies were limited to light and small angle x-ray scattering techniques, usually in dilute solution. SANS from blends of normal and labeled molecules could give direct information on chain conformation in bulk polymers. Water-soluble polymers may be examined in H 2 O/D 2 O mixtures using contrast variation methods to provide further information on polymer structure. This paper reviews some of the information provided by this technique using examples of experiments performed at the National Center for Small-Angle Scattering Research (NCSASR)

Modeling pesticide loadings from the San Joaquin watershed into the Sacramento-San Joaquin Delta using SWAT

Science.gov (United States)

Chen, H.; Zhang, M.

2016-12-01

The Sacramento-San Joaquin Delta is an ecologically rich, hydrologically complex area that serves as the hub of California's water supply. However, pesticides have been routinely detected in the Delta waterways, with concentrations exceeding the benchmark for the protection of aquatic life. Pesticide loadings into the Delta are partially attributed to the San Joaquin watershed, a highly productive agricultural watershed located upstream. Therefore, this study aims to simulate pesticide loadings to the Delta by applying the Soil and Water Assessment Tool (SWAT) model to the San Joaquin watershed, under the support of the USDA-ARS Delta Area-Wide Pest Management Program. Pesticide use patterns in the San Joaquin watershed were characterized by combining the California Pesticide Use Reporting (PUR) database and GIS analysis. Sensitivity/uncertainty analyses and multi-site calibration were performed in the simulation of stream flow, sediment, and pesticide loads along the San Joaquin River. Model performance was evaluated using a combination of graphic and quantitative measures. Preliminary results indicated that stream flow was satisfactorily simulated along the San Joaquin River and the major eastern tributaries, whereas stream flow was less accurately simulated in the western tributaries, which are ephemeral small streams that peak during winter storm events and are mainly fed by irrigation return flow during the growing season. The most sensitive parameters to stream flow were CN2, SOL_AWC, HRU_SLP, SLSUBBSN, SLSOIL, GWQMN and GW_REVAP. Regionalization of parameters is important as the sensitivity of parameters vary significantly spatially. In terms of evaluation metric, NSE tended to overrate model performance when compared to PBIAS. Anticipated results will include (1) pesticide use pattern analysis, (2) calibration and validation of stream flow, sediment, and pesticide loads, and (3) characterization of spatial patterns and temporal trends of pesticide yield.

The Potential Effect of Chinese Herbal Formula Hongqijiangzhi Fang in Improving NAFLD: Focusing on NLRP3 Inflammasome and Gut Microbiota

Directory of Open Access Journals (Sweden)

Shu Liang

2018-01-01

Full Text Available The present study investigates the potential therapeutic mechanism underlying the effects of the Chinese herbal formula Hongqijiangzhi Fang (HJF on nonalcoholic fatty liver disease (NAFLD in rats. Male Sprague Dawley (SD rats were randomly divided into 4 groups (n=8: control group was fed a normal diet, three other groups were fed high-fat diets (HFD, and the two treatment groups were intragastrically given a compound probiotic or HJF during the molding time. After 16 w, related indices were detected. The results showed that HJF significantly reduced abdominal aorta serum cholesterol (TC, triglyceride (TG, low-density lipoprotein (LDL, IL-1β, and IL-18, portal venous serum lipopolysaccharide (LPS, and liver TC and TG levels in HFD-fed rats. HJF ameliorated hepatic steatosis in the liver and improved the intestinal barrier in HFD-fed rats. Activation of the NLRP3 inflammasome was reduced by HJF in HFD-fed rats. Additionally, the abundances of A. muciniphila (Verrucomicrobiaceae, F. rappini (Helicobacteraceae, and Enterobacteriaceae bacteria significantly decreased in HJF-treated HFD-fed rats. In conclusion, these result suggested that the Chinese herbal formula HJF reduced hepatic steatosis maybe through decreasing certain gut bacteria (such as Enterobacteriaceae bacteria and F. rappini, alleviating intestinal endotoxemia and reducing NLRP3 inflammasome activation.

Butterfly fauna in Mount Gariwang-san, Korea

Directory of Open Access Journals (Sweden)

Cheol Min Lee

2016-06-01

Full Text Available The aim of this study is to elucidate butterfly fauna in Mt. Gariwang-san, Korea. A field survey was conducted from 2010 to 2015 using the line transect method. A literature survey was also conducted. A total of 2,037 butterflies belonging to 105 species were recorded. In the estimation of species richness of butterfly, 116 species were estimated to live in Mt. Gariwang-san. In butterfly fauna in Mt. Gariwang-san, the percentage of northern species was very high and the percentage of grassland species was relatively higher than that of forest edge species and forest interior species. Sixteen red list species were found. In particular, Mimathyma nycteis was only recorded in Mt. Gariwang-san. When comparing the percentage of northern species and southern species including those recorded in previous studies, the percentage of northern species was found to have decreased significantly whereas that of southern species increased. We suggest that the butterfly community, which is distributed at relatively high altitudes on Mt. Gariwang-san, will gradually change in response to climate change.

Distribution and demography of San Francisco gartersnakes (Thamnophis sirtalis tetrataenia) at Mindego Ranch, Russian Ridge Open Space Preserve, San Mateo County, California

Science.gov (United States)

Kim, Richard; Halstead, Brian J.; Wylie, Glenn D.; Casazza, Michael L.

2018-04-26

San Francisco gartersnakes (Thamnophis sirtalis tetrataenia) are a subspecies of common gartersnakes endemic to the San Francisco Peninsula of northern California. Because of habitat loss and collection for the pet trade, San Francisco gartersnakes were listed as endangered under the precursor to the Federal Endangered Species Act. A population of San Francisco gartersnakes resides at Mindego Ranch, San Mateo County, which is part of the Russian Ridge Open Space Preserve owned and managed by the Midpeninsula Regional Open Space District (MROSD). Because the site contained non-native fishes and American bullfrogs (Lithobates catesbeianus), MROSD implemented management to eliminate or reduce the abundance of these non-native species in 2014. We monitored the population using capture-mark-recapture techniques to document changes in the population during and following management actions. Although drought confounded some aspects of inference about the effects of management, prey and San Francisco gartersnake populations generally increased following draining of Aquatic Feature 3. Continued management of the site to keep invasive aquatic predators from recolonizing or increasing in abundance, as well as vegetation management that promotes heterogeneous grassland/shrubland near wetlands, likely would benefit this population of San Francisco gartersnakes.

San Francisco Bay Long Term Management Strategy for Dredging

Science.gov (United States)

The San Francisco Bay Long Term Management Strategy (LTMS) is a cooperative effort to develop a new approach to dredging and dredged material disposal in the San Francisco Bay area. The LTMS serves as the Regional Dredging Team for the San Francisco area.

San Juan Uchucuanicu: évolution historique

Directory of Open Access Journals (Sweden)

1975-01-01

Full Text Available La communauté de San Juan est reconnue depuis 1939. Une première partie concerne l’organisation de la reducción de San Juan vers le milieu du XVIe siècle. Le poids fiscal s’exerce durement sur le village et la crise est générale dans toute la vallée du Chancay au XVIIe. siècle. La christianisation des habitants est définitive au milieu de ce même siècle. C’est vers la fin du XVIIe siècle et durant tout le XVIIIe que se multiplient les conflits entre San Juan et les villages voisins liés aux terrains de pâture et à la possession de l’eau. La deuxième partie du travail concerne les rapports de la communauté de San Juan avec le Pérou contemporain : contrainte fiscale toujours très lourde durant la fin de l’époque coloniale, exactions des militaires juste avant l’indépendance. La période républicaine voit toujours les conflits avec les villages voisins mais aussi la naissance de familles qui cherchent à retirer le maximum de la communauté. Les terres sont divisées et attribuées : la détérioration de l’organisation communale traditionnelle est manifeste. L4es conflits se multiplient entre petits propriétaires, mais aussi avec les haciendas voisines : c’est l’apparition d’une véritable lutte de classes. La situation actuelle est incertaine, le poids de l’économie marchande se développe avec l’exode des jeunes. Que sera la communauté San Juan à la fin de ce siècle? La comunidad de San Juan está reconocida desde 1939. La primera parte concierne a la organización de la 'reducción' de San Juan hacia mediados del siglo XVI. El peso fiscal se ejerce duramente sobre el pueblo y en el siglo XVII la crisis es general en todo el valle de Chancay. Hacia mediados del mismo siglo la cristianización de los habitantes es definitiva. Es hacia fines del siglo XVII y durante todo el siglo XVIII que se multiplican los conflictos entre San Juan y los pueblos vecinos, los que están relacionados con los terrenos de

Quaternary geology of Alameda County, and parts of Contra Costa, Santa Clara, San Mateo, San Francisco, Stanislaus, and San Joaquin counties, California: a digital database

Science.gov (United States)

Helley, E.J.; Graymer, R.W.

1997-01-01

Alameda County is located at the northern end of the Diablo Range of Central California. It is bounded on the north by the south flank of Mount Diablo, one of the highest peaks in the Bay Area, reaching an elevation of 1173 meters (3,849 ft). San Francisco Bay forms the western boundary, the San Joaquin Valley borders it on the east and an arbitrary line from the Bay into the Diablo Range forms the southern boundary. Alameda is one of the nine Bay Area counties tributary to San Francisco Bay. Most of the country is mountainous with steep rugged topography. Alameda County is covered by twenty-eight 7.5' topographic Quadrangles which are shown on the index map. The Quaternary deposits in Alameda County comprise three distinct depositional environments. One, forming a transgressive sequence of alluvial fan and fan-delta facies, is mapped in the western one-third of the county. The second, forming only alluvial fan facies, is mapped in the Livermore Valley and San Joaquin Valley in the eastern part of the county. The third, forming a combination of Eolian dune and estuarine facies, is restricted to the Alameda Island area in the northwestern corner of the county.

San Francisco Bay Water Quality Improvement Fund

Science.gov (United States)

EPAs grant program to protect and restore San Francisco Bay. The San Francisco Bay Water Quality Improvement Fund (SFBWQIF) has invested in 58 projects along with 70 partners contributing to restore wetlands, water quality, and reduce polluted runoff.,

Una aportación al estudio del cuento fang de Guinea Ecuatorial en lengua española / A CONTRIBUTION TO THE STUDY ABOUT THE FANG TALES FROM EQUATORIAL GUINEA IN SPANISH LANGUAGE

Directory of Open Access Journals (Sweden)

María Teresa Abaga Envó

2009-06-01

Full Text Available Resumen: Una lectura sobre los estudios narratológicos revela que el acto narrativo es un hecho consustancial al ser humano. “Somos el homo sapiens, porque somos el homo narrans”, diría el académico José María Merino (2002: 57. De las estructuras narrativas, el cuento oral tradicional se alza como la forma más antigua. Tan antigua y presente en todos los pueblos que componentes semánticos y formales se repiten en relatos de distintas culturas. Tales aspectos constituyen el objeto de análisis de este repertorio de cuentos fantásticos de Guinea Ecuatorial transmitidos en lengua española. En dicho entorno, el cuento oral fang se manifiesta como un arte viviente. No es un evento pensado sólo para niños; toda la comunidad participa de esta “fiesta” que se verá enaltecida por la presencia del canto. Dada la escasa proliferación de estudios del relato oral africano y en particular del guineano, se hace imperativo partir de estudios occidentales, lo cual nos desliza hacia el terreno del comparativismo. Sin embargo, no siempre dichos estudios son confirmados en esta investigación que concluye con las siguientes tesis: el criterio verdad y ficción al que se recurre para delimitar ciertas narraciones tradicionales europeas queda difuminado; uso irregular de las fórmulas de abertura y cierre; la asignación del fin lúdico de los cuentos fantásticos se acompaña del didáctico y la pretendida universalización del método estructuralista formal de Vladimir Propp, expuesta en Morfología del cuento (1987, se vislumbra inoperante, pues quedan reducidas las treinta y una funciones y la sucesión lineal de las mismas. Los temas y los motivos, arropados por el espíritu de la cultura donde emergen, son similares a los identificados en compilaciones españolas o internacionales. Finalmente, la naturaleza oral tradicional del repertorio queda patente a través de las nueve “Leyes Épicas” establecidas por Axel Orlik (1965: la Ley de

Development of 40m SANS and Its Utilization Techniques

International Nuclear Information System (INIS)

Choi, Sung Min; Kim, Tae Hwan

2010-06-01

Small angle neutron scattering (SANS) has been a very powerful tool to study nanoscale (1-100 nm) bulk structures in various materials such as polymer, self assembled materials, nano-porous materials, nano-magnetic materials, metal and ceramics. Understanding the importance of the SANS instrument, the 8m SANS instrument was installed at the CN beam port of HANARO in 2001. However, without having a cold neutron source, the beam intensity is fairly low and the Q-range is rather limited due to short instrument length. In July 1, 2003, therefore, the HANARO cold neutron research facility project was launched and a state of the art 40m SANS instrument was selected as top-priority instrument. The development of the 40m SANS instrument was completed as a joint project between Korea Advanced Institute of Science and Technology and the HANARO in 2010. Here, we report the specification of a state of art 40m SANS instrument at HANARO

San Diego's High School Dropout Crisis

Science.gov (United States)

Wilson, James C.

2012-01-01

This article highlights San Diego's dropout problem and how much it's costing the city and the state. Most San Diegans do not realize the enormous impact high school dropouts on their city. The California Dropout Research Project, located at the University of California at Santa Barbara, has estimated the lifetime cost of one class or cohort of…

Coal exploration in the Alto San Jorge area, Cordoba Department. Exploracion de carbones en el Ato San Jorge, Departamento de Cordoba

Energy Technology Data Exchange (ETDEWEB)

Ospina, L H; Oquendo, G G [Geominas Ltda, Medellin (Colombia)

1989-01-01

A Mining Feasibility Study in the Area of Alto San Jorge, Department of Cordoba, Colombia, was commissioned by CARBOCOL S.A. to the Consortium Geominas-NACI. An area of 800 Ka2 was explored to define surface mining possibilities within two subareas referred to as Alto San Jorge and San Pedro Ure. Rocks of Cretaceous, Tertiary and Quaternary age crop out in the zone. In the subarea Alto San Jorge the principal structure is a syncline with a south-north direction. The San Pedro Ure subarea is formed by undulations with flanks of low dip, the most important being the San Antonio Syncline because it contains the mining block. The geological study of the surface demonstrated the existence of coal in the Oligocene Cienaga de Oro Formation and the Niocene Cerrito Formation, with potential resources of 6.3 billion tons. The subsequent exploration of the subsoil, with 20.618 m of drilling, permitted determination of demonstrated reserves in the order of 2.9 billion tons within two areas. In the sector selected for the mine plan, in the area of San Pedro-Puerto Libertador, 7.791 m of drilling was accomplished to define a demonstrated reserve of 515 million tons of coal down to a depth of 200. The combustible type coal has 5.000 cal/g. Complete mining schedules were developed at the prefeasibility level for two surface mines with productions of 1.5 MMTY and 4 MMTY. 9 figs., 3 tabs., 28 refs.

Cenobios leoneses altomedievales ante la europeización: San Pedro y San Pablo de Montes, Santiago y San Martín de Peñalba y San Miguel de Escalada

Directory of Open Access Journals (Sweden)

Martínez Tejera, Artemio Manuel

2002-06-01

Full Text Available The following paper analyses the behaviour of three of the most important monastic communities in the reing of Asturias-Leon for the ninth and then centuries. During this period we witness the implementation of a new ordo, or liturgical ritual that replaces the Hispanic one, strongly established in the Territorium. The liturgical adaptation produces tension and conflicts among the members of different monastic communities, and even between the Episcopate and the monarchy - being King Alfonso VI. In some of the monasteries, the arrival of the new ordo causes the adaptation of the liturgical space, with subsequent changes in liturgical furniture.

El presente estudio pretende analizar el comportamiento de tres de las más importantes comunidades monásticas astur-leonesas de los siglos IX y X (San Pedro y San Pablo de Montes, Santiago y San Martín de Peñalba y San Miguel de Escalada ante la recepción e implantación de aquel nuevo ordo o ritual litúrgico que vino a sustituir al Hispánico, fuertemente asentado en el territorium. Readaptación litúrgica que, con distinta intensidad, producirá tensiones y enfrentamientos entre los miembros de las distintas comunidades monásticas, incluso entre el episcopado y la monarquía (personificada en la figura de Alfonso VI, pero no únicamente. En alguno de estos monasterios la llegada del nuevo ordo supondrá, además, la readaptación de su espacio litúrgico, lo que trajo consigo significativas modificaciones constructivas.

O ENVELHECIMENTO, A DOENÇA DE ALZHEIMER E AS CONTRIBUIÇÕES DO PROGRAMA DE ENRIQUECIMENTO INSTRUMENTAL (PEI

Directory of Open Access Journals (Sweden)

Antonia Rozeli Roberto de Oliveira

2010-06-01

Full Text Available This article suggests that the aging process has unique and distinct features. A distinction is made between normal and pathological aging. Actually we are concerned that a successful aging is in close relationship with the pre-vention of diseases, and maintenance of physical and cognitive activities. Epidemiological studies show that elderly people with mild cognitive deficts are at greater risk of developing Alzheimer's disease. This disease affects brain function, primarily memory, and also speech, executive functions, praxias and gnosias. Besides the current pharmacological approach, alterna-tive therapies, like neuropsychological rehabilitation, are in current use and contributes in a great amount to the improvement of cognitive and behav-ioral functions. In this article we gave special attention using PEI and EAM, in neuropsychological rehabilitation programs directed to Alzheimer`s dis-ease, focusing the improvement of residual functions and aiming the reduc-tion of the impact that this disease brings to the quality of life.

77 FR 46115 - Notice of Inventory Completion: San Diego Museum of Man, San Diego, CA

Science.gov (United States)

2012-08-02

...The San Diego Museum of Man has completed an inventory of human remains in consultation with the appropriate Indian tribe, and has determined that there is a cultural affiliation between the human remains and a present-day Indian tribe. Representatives of any Indian tribe that believes itself to be culturally affiliated with the human remains may contact the San Diego Museum of Man. Repatriation of the human remains to the Indian tribe stated below may occur if no additional claimants come forward.

Effects of Choto-san and Chotoko on thiopental-induced sleeping time

OpenAIRE

JEENAPONGSA, Rattima; Tohda, Michihisa; Watanabe, Hiroshi

2003-01-01

Choto-san has been used for treatment of centrally regulated disorders such as dementia, hypertension, headache and vertigo. Our laboratory showed that Choto-san improved learning memory in ischemic mice. It is noticeable that Choto-san treated animals and animals that underwent conducting occlusion of common carotid arteries (2VO) operation slept longer than the normal animals. Therefore, this study aimed to clarify the effects of Choto-san and its related component; Chotoko and Choto-san wi...

33 CFR 110.120 - San Luis Obispo Bay, Calif.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false San Luis Obispo Bay, Calif. 110... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.120 San Luis Obispo Bay, Calif. (a) Area A-1. Area A-1 is the water area bounded by the San Luis Obispo County wharf, the shoreline, a line drawn...

Species Observations (poly) - San Diego County [ds648

Data.gov (United States)

California Natural Resource Agency — Created in 2009, the SanBIOS database serves as a single repository of species observations collected by various departments within the County of San Diego's Land...

Mammal Track Counts - San Diego County [ds442

Data.gov (United States)

California Natural Resource Agency — The San Diego Tracking Team (SDTT) is a non-profit organization dedicated to promoting the preservation of wildlife habitat in San Diego County through citizen-based...

Species Observations (poly) - San Diego County [ds648

Data.gov (United States)

California Department of Resources — Created in 2009, the SanBIOS database serves as a single repository of species observations collected by various departments within the County of San Diego's Land...

Biological and associated water-quality data for lower Olmos Creek and upper San Antonio River, San Antonio, Texas, March-October 1990

Science.gov (United States)

Taylor, R. Lynn

1995-01-01

Biological and associated water-quality data were collected from lower Olmos Creek and upper San Antonio River in San Antonio, Texas, during March-October 1990, the second year of a multiyear data-collection program. The data will be used to document water-quality conditions prior to implementation of a proposal to reuse treated wastewater to irrigate city properties in Olmos Basin and Brackenridge Parks and to augment flows in the Olmos Creek/San Antonio River system.

Remembering San Diego

International Nuclear Information System (INIS)

Chuyanov, V.

1999-01-01

After 6 years of existence the ITER EDA project in San Diego, USA, was terminated by desition of the US Congress. This article describes how nice it was for everybody as long as it lasted and how sad it is now

Multifunctional triblock co-polymer mP3/4HB-b-PEG-b-lPEI for efficient intracellular siRNA delivery and gene silencing.

Science.gov (United States)

Zhou, Li; Chen, Zhifei; Wang, Feifei; Yang, Xiuqun; Zhang, Biliang

2013-04-01

A non-viral siRNA carrier composed of mono-methoxy-poly (3-hydroxybutyrate-co-4-hydroxybutyrate)-block-polyethylene glycol-block-linear polyethyleneimine (mP3/4HB-b-PEG-b-lPEI) was synthesized using 1800 Da linear polyethyleneimine and evaluated for siRNA delivery. Our study demonstrated that siRNA could be efficiently combined with mP3/4HB-b-PEG-b-lPEI (mAG) co-polymer and was protected from nuclease degradation. The combined siRNA were released from the complexes easily under heparin competition. The particle size of the mAG/siRNA complexes was 158 nm, with a ζ-potential of around 28 mV. Atomic force microscopy images displayed spherical and homogeneously distributed complexes. The mAG block co-polymer displayed low cytotoxicity and efficient cellular uptake of Cy3-siRNA in A549 cells by flow cytometry and confocal microscopy. In vitro transfection efficiency of the block co-polymer was assessed using siRNA against luciferase in cultured A549-Luc, HeLa-Luc, HLF-Luc, A375-Luc and MCF-7-Luc cells. A higher transfection efficiency and lower cytotoxicity was obtained by mAG block co-polymer in five cell lines. Furthermore, a remarkable improvement in luciferase gene silencing efficiency of the mAG complex (up to 90-95%) over that of Lipofectamine™ 2000 (70-82%) was observed in HLF-Luc and A375-Luc cells. Additionally, a mAG/p65-siRNA complex also showed a better capability than Lipofectamine™ 2000/p65-siRNA complex to drastically reduce the p65 mRNA level down to 10-16% in HeLa, U251 and HUVEC cells at an N/P ratio of 70. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

Update: San Andreas Fault experiment

Science.gov (United States)

Christodoulidis, D. C.; Smith, D. E.

1984-01-01

Satellite laser ranging techniques are used to monitor the broad motion of the tectonic plates comprising the San Andreas Fault System. The San Andreas Fault Experiment, (SAFE), has progressed through the upgrades made to laser system hardware and an improvement in the modeling capabilities of the spaceborne laser targets. Of special note is the launch of the Laser Geodynamic Satellite, LAGEOS spacecraft, NASA's only completely dedicated laser satellite in 1976. The results of plate motion projected into this 896 km measured line over the past eleven years are summarized and intercompared.

Vabariigi aastapäev San Franciscos / Heino Valvur ; foto: Heino Valvur

Index Scriptorium Estoniae

Valvur, Heino

2006-01-01

veebruarikuu möödus San Franciscos Eesti Vabariigi 88. aastapäeva pühitsedes: traditsiooniliselt tähistas aastapäeva San Francisco Seenioride Klubi koosviibimisega, E.E.L.K. San Francisco koguduses peeti jumalateenistus ja koosviibimine, kus noored esitasid rahvalaule, San Francisco Eesti Selts tähistas aastapäeva 25. veebruaril aktuse ja koosviibimisega

76 FR 70480 - Otay River Estuary Restoration Project, South San Diego Bay Unit of the San Diego Bay National...

Science.gov (United States)

2011-11-14

... River Estuary Restoration Project, South San Diego Bay Unit of the San Diego Bay National Wildlife...), intend to prepare an environmental impact statement (EIS) for the proposed Otay River Estuary Restoration... any one of the following methods. Email: [email protected] . Please include ``Otay Estuary NOI'' in the...

Backwater Flooding in San Marcos, TX from the Blanco River

Science.gov (United States)

Earl, Richard; Gaenzle, Kyle G.; Hollier, Andi B.

2016-01-01

Large sections of San Marcos, TX were flooded in Oct. 1998, May 2015, and Oct. 2015. Much of the flooding in Oct. 1998 and Oct. 2015 was produced by overbank flooding of San Marcos River and its tributaries by spills from upstream dams. The May 2015 flooding was almost entirely produced by backwater flooding from the Blanco River whose confluence is approximately 2.2 miles southeast of downtown. We use the stage height of the Blanco River to generate maps of the areas of San Marcos that are lower than the flood peaks and compare those results with data for the observed extent of flooding in San Marcos. Our preliminary results suggest that the flooding occurred at locations more than 20 feet lower than the maximum stage height of the Blanco River at San Marcos gage (08171350). This suggest that the datum for either gage 08171350 or 08170500 (San Marcos River at San Marcos) or both are incorrect. There are plans for the U.S. Army Corps of Engineers to construct a Blanco River bypass that will divert Blanco River floodwaters approximately 2 miles farther downstream, but the $60 million price makes its implementation problematic.

Shen-Qi-Jie-Yu-Fang exerts effects on a rat model of postpartum depression by regulating inflammatory cytokines and CD4+CD25+ regulatory T cells

Directory of Open Access Journals (Sweden)

Li JY

2016-04-01

Full Text Available Jingya Li,1,* Ruizhen Zhao,1,* Xiaoli Li,1 Wenjun Sun,1 Miao Qu,1 Qisheng Tang,1 Xinke Yang,1 Shujing Zhang2 1Third Affiliated Hospital, 2School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, People’s Republic of China *These authors contributed equally to this work Background: Shen-Qi-Jie-Yu-Fang (SJF is composed of eight Chinese medicinal herbs. It is widely used in traditional Chinese medicine for treating postpartum depression (PPD. Previous studies have shown that SJF treats PPD through the neuroendocrine mechanism. Aim: To further investigate the effect of SJF on the immune system, including the inflammatory response system and CD4+CD25+ regulatory T (Treg cells. Materials and methods: Sprague Dawley rats were used to create an animal model of PPD by inducing hormone-simulated pregnancy followed by hormone withdrawal. After hormone withdrawal, the PPD rats were treated with SJF or fluoxetine for 1, 2, and 4 weeks. Levels of Treg cells in peripheral blood were measured by flow cytometry analysis. Serum interleukin (IL-1β and IL-6 were evaluated by enzyme-linked immunosorbent assay, and gene and protein expressions of IL-1RI, IL-6Rα, and gp130 in the hippocampus were observed by reverse-transcription polymerase chain reaction and Western blot. Results: Serum IL-1β in PPD rats increased at 2 weeks and declined from then on, while serum IL-6 increased at 1, 2, and 4 weeks. Both IL-1β and IL-6 were downregulated by SJF and fluoxetine. Changes in gene and protein expressions of IL-1RI and gp130 in PPD rats were consistent with changes in serum IL-1β, and were able to be regulated by SJF and fluoxetine. The levels of Treg cells were negatively correlated with serum IL-1β and IL-6, and were decreased in PPD rats. The levels of Treg cells were increased by SJF and fluoxetine. Conclusion: Dysfunction of proinflammatory cytokines and Tregs in different stages of PPD was attenuated by SJF and fluoxetine through

33 CFR 165.1187 - Security Zones; Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay...

Science.gov (United States)

2010-07-01

... Limited Access Areas Eleventh Coast Guard District § 165.1187 Security Zones; Golden Gate Bridge and the... Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, in San Francisco Bay, California. (b... siren, radio, flashing light, or other means, the operator of a vessel shall proceed as directed. [COTP...

Leguay Jean-Pierre, 1999, La pollution au Moyen-Âge, Edition Jean-Paul Gisserot, Paris

Directory of Open Access Journals (Sweden)

Sandrine Rousseau

2004-10-01

Full Text Available Si vous aviez du Moyen-Âge la vision qu’en donnent certaines gravures : une belle princesse au bras d’un preux chevalier, Jean-Pierre Leguay, professeur d’histoire médiévale à l’université de Haute-Normandie, risque de vous surprendre. En effet, son ouvrage, La pollution au Moyen-Âge modifiera sans doute cette vision idyllique. Pour commencer, sachez que la princesse et son preux chevalier ont les pieds dans la boue, une boue composée de la fange, d’excréments humains, de déchets des bouchers...

Leguay Jean-Pierre, 1999, La pollution au Moyen-Âge, Edition Jean-Paul Gisserot, Paris

OpenAIRE

Rousseau, Sandrine

2004-01-01

Si vous aviez du Moyen-Âge la vision qu’en donnent certaines gravures : une belle princesse au bras d’un preux chevalier, Jean-Pierre Leguay, professeur d’histoire médiévale à l’université de Haute-Normandie, risque de vous surprendre. En effet, son ouvrage, La pollution au Moyen-Âge modifiera sans doute cette vision idyllique. Pour commencer, sachez que la princesse et son preux chevalier ont les pieds dans la boue, une boue composée de la fange, d’excréments humains, de déchets des bouchers...

Fitting the datum of SANS with Pxy program

International Nuclear Information System (INIS)

Sun, Liangwei; Peng, Mei; Chen, Liang

2009-04-01

The thesis introduces the basic theory of Small-Angle neutron scattering, enumerates several approximate law. It simply describes the components of Small-Angle neutron spectrometer (SANS) and the parameters of SANS of Budapest Neutron Center (BNC) in Hungary. During the period of studying at Budapest Neutron Center in Hungary, the experiments of wavelength calibration was carried out with SIBE and the SANS experiments of sample Micelles. The experiments are briefly introduced. Pxy program is used to fit these datum, and the results of wavelength and sizes of sample Micelles are presented. (authors)

Holocene slip rates along the San Andreas Fault System in the San Gorgonio Pass and implications for large earthquakes in southern California

Science.gov (United States)

Heermance, Richard V.; Yule, Doug

2017-06-01

The San Gorgonio Pass (SGP) in southern California contains a 40 km long region of structural complexity where the San Andreas Fault (SAF) bifurcates into a series of oblique-slip faults with unknown slip history. We combine new 10Be exposure ages (Qt4: 8600 (+2100, -2200) and Qt3: 5700 (+1400, -1900) years B.P.) and a radiocarbon age (1260 ± 60 years B.P.) from late Holocene terraces with scarp displacement of these surfaces to document a Holocene slip rate of 5.7 (+2.7, -1.5) mm/yr combined across two faults. Our preferred slip rate is 37-49% of the average slip rates along the SAF outside the SGP (i.e., Coachella Valley and San Bernardino sections) and implies that strain is transferred off the SAF in this area. Earthquakes here most likely occur in very large, throughgoing SAF events at a lower recurrence than elsewhere on the SAF, so that only approximately one third of SAF ruptures penetrate or originate in the pass.Plain Language SummaryHow large are earthquakes on the southern San Andreas Fault? The answer to this question depends on whether or not the earthquake is contained only along individual fault sections, such as the Coachella Valley section north of Palm Springs, or the rupture crosses multiple sections including the area through the San Gorgonio Pass. We have determined the age and offset of faulted stream deposits within the San Gorgonio Pass to document slip rates of these faults over the last 10,000 years. Our results indicate a long-term slip rate of 6 mm/yr, which is almost 1/2 of the rates east and west of this area. These new rates, combined with faulted geomorphic surfaces, imply that large magnitude earthquakes must occasionally rupture a 300 km length of the San Andreas Fault from the Salton Sea to the Mojave Desert. Although many ( 65%) earthquakes along the southern San Andreas Fault likely do not rupture through the pass, our new results suggest that large >Mw 7.5 earthquakes are possible on the southern San Andreas Fault and likely

City of San Francisco, California street tree resource analysis

Science.gov (United States)

E.G. McPherson; J.R. Simpson; P.J. Peper; Q. Xiao

2004-01-01

Street trees in San Francisco are comprised of two distinct populations, those managed by the city’s Department of Public Works (DPW) and those managed by private property owners with or without the help of San Francisco’s urban forestry nonprofit, Friends of the Urban Forest (FUF). These two entities believe that the public’s investment in stewardship of San Francisco...

Trouble Brewing in San Francisco. Policy Brief

Science.gov (United States)

Buck, Stuart

2010-01-01

The city of San Francisco will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that San Francisco faces an aggregate $22.4 billion liability for pensions and retiree health benefits that are underfunded--including $14.1 billion for the city…

77 FR 66499 - Environmental Impact Statement: San Bernardino and Los Angeles Counties, CA

Science.gov (United States)

2012-11-05

... San Bernardino, 285 East Hospitality Lane, San Bernardino, California 92408 (2) Sheraton Ontario..., November 13, 2012 from 5-7 p.m. at the Hilton San Bernardino, 285 East Hospitality Lane, San Bernardino...

33 CFR 110.74c - Bahia de San Juan, PR.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bahia de San Juan, PR. 110.74c Section 110.74c Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio...

San Francisco Accelerator Conference

International Nuclear Information System (INIS)

Southworth, Brian

1991-01-01

'Where are today's challenges in accelerator physics?' was the theme of the open session at the San Francisco meeting, the largest ever gathering of accelerator physicists and engineers

Effects of Qi-Fang-Xi-Bi-Granules on Cartilage Morphology and C/ebpα Promoter Methylation in Rats with Knee Osteoarthritis

Directory of Open Access Journals (Sweden)

Xinxin Wang

2018-01-01

Full Text Available Objective. To investigate the effects of Qi-Fang-Xi-Bi-Granules (QFXBGs on cartilage morphology and methylation of C/ebpα (CCAAT/enhancer binding proteinα at the promoter region. Methods. Knee osteoarthritis (KOA modeling was performed in rats in accordance with Hulth’s method, and control group received sham operation. Eight weeks after KOA modeling, the rats in the KOA modeling group were further divided into 6 groups. Each group was given the appropriate drug. After 8 weeks, half of the rats were used for Micro-CT scan, HE staining, ABH/OG staining, immunohistochemistry, and TUNNEL staining of the knee joint tissue, and the other half were used to examine C/ebpα promoter methylation. Results. The three dose groups of QFXBGs all showed lower degrees of surface fissures and flaking, thicker cartilage layer, and restored chondrocyte and subchondral bone morphology, compared with the KOA model group. C/ebpα-22 promoter methylation levels in the high- and low-dose groups were significantly higher than that in the KOA modeling group (p<0.05, while C/ebpα-2 promoter methylation level in the medium-dose group was significantly higher than that in the KOA modeling group (p<0.05. Conclusions. QFXBGs may alleviate articular cartilage degeneration through promoting C/ebpα-2 or C/ebpα-22 methylation at specific promoter sites.

Trouble Brewing in San Diego. Policy Brief

Science.gov (United States)

Buck, Stuart

2010-01-01

The city of San Diego will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that San Diego faces total of $45.4 billion, including $7.95 billion for the county pension system, $5.4 billion for the city pension system, and an estimated $30.7…

Corps sans organes et anamnèse

DEFF Research Database (Denmark)

Wilson, Alexander

2011-01-01

Je trace certains liens entre le corps sans organes de Deleuze et Guattari et les principes de l’organologie générale que décrit Bernard Stiegler.......Je trace certains liens entre le corps sans organes de Deleuze et Guattari et les principes de l’organologie générale que décrit Bernard Stiegler....

Coastal Cactus Wren, San Diego Co. - 2009 [ds702

Data.gov (United States)

California Natural Resource Agency — The San Diego Multiple Species Conservation program (MSCP) was developed for the conservation of plants and animals in the southeast portion of San Diego County....

Coastal Cactus Wren, San Diego Co. - 2011 [ds708

Data.gov (United States)

California Natural Resource Agency — The San Diego Multiple Species Conservation program (MSCP) was developed for the conservation of plants and animals in the southeast portion of San Diego County....

Cacao use and the San Lorenzo Olmec

Science.gov (United States)

Powis, Terry G.; Cyphers, Ann; Gaikwad, Nilesh W.; Grivetti, Louis; Cheong, Kong

2011-01-01

Mesoamerican peoples had a long history of cacao use—spanning more than 34 centuries—as confirmed by previous identification of cacao residues on archaeological pottery from Paso de la Amada on the Pacific Coast and the Olmec site of El Manatí on the Gulf Coast. Until now, comparable evidence from San Lorenzo, the premier Olmec capital, was lacking. The present study of theobromine residues confirms the continuous presence and use of cacao products at San Lorenzo between 1800 and 1000 BCE, and documents assorted vessels forms used in its preparation and consumption. One elite context reveals cacao use as part of a mortuary ritual for sacrificial victims, an event that occurred during the height of San Lorenzo's power. PMID:21555564

[Bushen Huoxue Fang promotes the apoptosis of epithelial cells in the prostatic ductal system of rats with benign prostatic hyperplasia].

Science.gov (United States)

Sun, Jie; Li, Qiu-Fen; Tian, Dai-Zhi; Jiang, Shao-Bo; Wu, Xian-De; Qiu, Shun-An; Ren, Xiao-Gang; Li, Yu-Bing

2014-09-01

To investigate the effects of Bushen Huoxue Fang (BSHX) on the apoptosis of epithelial cells in the prostatic ductal system of rats with benign prostatic hyperplasia (BPH) and its possible action mechanism. One hundred 3- month-old male Wistar rats were randomly divided into four groups of equal number (control, castrated, BPH model, and BSHX). BPH models were made by subcutaneous injection of testosterone following castration; the rats in the BSHX group were treated intragastrically with BSHX at 2.34 g/ml after modeling, while those in the other two groups with equal volume of saline, all for 37 days. On the 38th day, all the rats were sacrificed and their prostates harvested for detection of the distribution of TGF-beta1 and alpha-actin and the count of positive cells in the prostatic ductal system by immunohistochemical staining. The apoptosis rate of epithelial cells in the prostatic ductal system was determined by TUNEL assay. The expression of TGF-beta1 was significantly increased in the rats of the BSHX group as compared with the BPH models in both the proximal prostatic duct ([15.28 +/- 4.30]% vs [36.42 +/- 8.10]%, P epithelial cells in the proximal prostatic duct ([39.42 +/- 9.20]% vs [3.86 +/- 1.34]%, P epithelial cells in the prostatic ductal system was significantly higher in the BSHX-treated rats than in the BPH models (P epithelial cells, and thus effectively inhibit benign prostatic hyperplasia.

On-line monitoring the extract process of Fu-fang Shuanghua oral solution using near infrared spectroscopy and different PLS algorithms

Science.gov (United States)

Kang, Qian; Ru, Qingguo; Liu, Yan; Xu, Lingyan; Liu, Jia; Wang, Yifei; Zhang, Yewen; Li, Hui; Zhang, Qing; Wu, Qing

2016-01-01

An on-line near infrared (NIR) spectroscopy monitoring method with an appropriate multivariate calibration method was developed for the extraction process of Fu-fang Shuanghua oral solution (FSOS). On-line NIR spectra were collected through two fiber optic probes, which were designed to transmit NIR radiation by a 2 mm flange. Partial least squares (PLS), interval PLS (iPLS) and synergy interval PLS (siPLS) algorithms were used comparatively for building the calibration regression models. During the extraction process, the feasibility of NIR spectroscopy was employed to determine the concentrations of chlorogenic acid (CA) content, total phenolic acids contents (TPC), total flavonoids contents (TFC) and soluble solid contents (SSC). High performance liquid chromatography (HPLC), ultraviolet spectrophotometric method (UV) and loss on drying methods were employed as reference methods. Experiment results showed that the performance of siPLS model is the best compared with PLS and iPLS. The calibration models for AC, TPC, TFC and SSC had high values of determination coefficients of (R2) (0.9948, 0.9992, 0.9950 and 0.9832) and low root mean square error of cross validation (RMSECV) (0.0113, 0.0341, 0.1787 and 1.2158), which indicate a good correlation between reference values and NIR predicted values. The overall results show that the on line detection method could be feasible in real application and would be of great value for monitoring the mixed decoction process of FSOS and other Chinese patent medicines.

Mammal Track Counts - San Diego County, 2010 [ds709

Data.gov (United States)

California Natural Resource Agency — The San Diego Tracking Team (SDTT) is a non-profit organization dedicated to promoting the preservation of wildlife habitat in San Diego County through citizen-based...

SANS observations on weakly flocculated dispersions

DEFF Research Database (Denmark)

Mischenko, N.; Ourieva, G.; Mortensen, K.

1997-01-01

Structural changes occurring in colloidal dispersions of poly-(methyl metacrylate) (PMMA) particles, sterically stabilized with poly-(12-hydroxystearic acid) (PHSA), while varying the solvent quality, temperature and shear rate, are investigated by small-angle neutron scattering (SANS......). For a moderately concentrated dispersion in a marginal solvent the transition on cooling from the effective stability to a weak attraction is monitored, The degree of attraction is determined in the framework of the sticky spheres model (SSM), SANS and rheological results are correlated....

SANS-II at SINQ: Installation of the former Risø-SANS facility

DEFF Research Database (Denmark)

Strunz, P.; Mortensen, K.; Janssen, S.

2004-01-01

SANS-II facility at SINQ (Paul Scherrer Institute)-the reinstalled former Riso small-angle neutron scattering instrument-is presented. Its operational characteristics are listed. Approaches for precise determination of wavelength, detector dead time and attenuation factors are described as well. (C...

Influence of Jiang Tang Bu Shen Fang on expression of IKKβ mRNA in diabetic rats%降糖补肾方对糖尿病大鼠IKKβ mRNA表达的影响

Institute of Scientific and Technical Information of China (English)

范冠杰; 孙晓泽; 唐咸玉; 孙璐; 曾星; 罗广波; 卢绮韵; 温建炫

2011-01-01

目的 观察降糖补肾方对小剂量链脲佐菌素(STZ)加高脂饲料诱导的糖尿病模型大鼠肌肉组织IKK激酶β(IKKβ)信使核糖核酸(mRNA)表达的影响.方法 雄性SD大鼠高脂饲料喂养4周后注射小剂量STZ,1周后测大鼠空腹血糖,血糖值>11.1 mmoL/L者为造模成功的大鼠,将造模成功的大鼠随机分为模型组和降糖补肾方干预组,另设阿司匹林对照组和空白对照组,药物干预4周,取大腿肌肉组织,采用聚合酶链反应逆转录RT-PCR技术检测IKKβ mRNA表达水平.结果 模型组IKKβ mRNA表达明显高于空白对照组,是空白对照组的5.098倍(P0.05.结论 降糖补肾方在一定程度上能抑制糖尿病大鼠IKKβ mRNA基因,这可能是降糖补肾方抑制炎症信号通路的传导而发挥其改善胰岛素抵抗治疗糖尿病的机制之一.%Objective To observe the influence of Jiang Tang Bu Shen Fang on the expression of I kappa P kinase (IKKp) mRNA in muscular tissue in diabetic rats induced by low-dose streptozotocin ( STZ) and high-fat diet (HFD). Methods Male SD rats were fed HFD for 4 weeks, and then injected low-dose STZ. After one week the level of fasting plasma glucose was detected in rats and those with higher than 11. 1 mmol/L of level of fasting plasma glucose were successfully modeled. The rats were randomly divided into the model group, low-dose, mid-dose and high-dose Jiang Tang Bu Shen Fang groups (low-dose, mid-dose and high-dose groups), aspirin group and blank group. All groups were intervened by relevant medicinal for 4 weeks. The expression of IKKp mRNA in muscular tissue was detected by using reverse transcription polymerase chain reaction (RT-PCR). Results The expression of IKKp mRNA in the model group was significantly higher than that in the blank group (5.098 times, P 0. 05 compared with that in the model group. Conclusion Jiang Tang Bu Shen Fang can inhibit IKK(3 mRNA to some extent in diabetic rats, which may be one of mechanisms of the

Marketing San Juan Basin gas

International Nuclear Information System (INIS)

Posner, D.M.

1988-01-01

Marketing natural gas produced in the San Juan Basin of New Mexico and Colorado principally involves four gas pipeline companies with significant facilities in the basin. The system capacity, transportation rates, regulatory status, and market access of each of these companies is evaluated. Because of excess gas supplies available to these pipeline companies, producers can expect improved take levels and prices by selling gas directly to end users and utilities as opposed to selling gas to the pipelines for system supply. The complexities of transporting gas today suggest that the services of an independent gas marketing company may be beneficial to smaller producers with gas supplies in the San Juan Basin

Transformation and reconstitution of Khoe-San identities : AAS le Fleur I, Griqua identities and post-apartheid Khoe-San revivalism (1894-2004)

NARCIS (Netherlands)

Besten, M.P.

2006-01-01

Focussing on AAS le fleur I (1867-1941), the Griqua, and post-apartheid Khoe-San revivalism, the dissertation examines changes in the articulation of Khoe-San identities in South-Africa. It shows the significance of shifting political, cultural and ideological power relations on the articulation of

San luo xuan mo xing ji qi liang hua fen zhi fang fa yan tao

NARCIS (Netherlands)

Ye, Y.; Leydesdorff, L.; Wu, Y.

2014-01-01

A discussed study on the Triple Helix with its quantitative analysis method. With brief introduction to background and progress of Triple-Helix(TH) researches, it is clarified that TH quantitative methodology focuses on the indicator of synergy (T) as reduction of uncertainty that can be shaped

Geological literature on the San Joaquin Valley of California

Science.gov (United States)

Maher, J.C.; Trollman, W.M.; Denman, J.M.

1973-01-01

The following list of references includes most of the geological literature on the San Joaquin Valley and vicinity in central California (see figure 1) published prior to January 1, 1973. The San Joaquin Valley comprises all or parts of 11 counties -- Alameda, Calaveras, Contra Costa, Fresno, Kern, Kings, Madera, Merced, San Joaquin, Stanislaus, and Tulare (figure 2). As a matter of convenient geographical classification the boundaries of the report area have been drawn along county lines, and to include San Benito and Santa Clara Counties on the west and Mariposa and Tuolumne Counties on the east. Therefore, this list of geological literature includes some publications on the Diablo and Temblor Ranges on the west, the Tehachapi Mountains and Mojave Desert on the south, and the Sierra Nevada Foothills and Mountains on the east.

75 FR 61611 - Modification of Class E Airspace; San Clemente, CA

Science.gov (United States)

2010-10-06

... INFORMATION CONTACT: Eldon Taylor, Federal Aviation Administration, Operations Support Group, Western Service... extension to a Class D surface area, at San Clemente Island NALF (Fredrick Sherman Field), San Clemente, CA... within the scope of that authority as it amends controlled airspace at San Clemente Island NALF (Fredrick...

77 FR 34984 - Notice of Intent To Repatriate a Cultural Item: San Diego Museum of Man, San Diego, CA

Science.gov (United States)

2012-06-12

...The San Diego Museum of Man, in consultation with the appropriate Indian tribes, has determined that a cultural item meets the definition of unassociated funerary object and repatriation to the Indian tribes stated below may occur if no additional claimants come forward. Representatives of any Indian tribe that believes itself to be culturally affiliated with the cultural item may contact the San Diego Museum of Man.

40 CFR 81.176 - San Luis Intrastate Air Quality Control Region.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 17 2010-07-01 2010-07-01 false San Luis Intrastate Air Quality Control Region. 81.176 Section 81.176 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.176 San Luis Intrastate Air Quality Control Region. The San Luis Intrastate...

L’Europe et les sans-papiers

OpenAIRE

Simonnot, Nathalie; Intrand, Caroline

2013-01-01

En Europe, les sans-papiers vivent des conditions socio-économiques particulièrement défavorables. Les systèmes de santé des pays européens sont peu performants pour le suivi des personnes sans papiers. Ils sont en outre souvent victimes de refus de soins. Pire, l’accès aux soins est dans certains pays progressivement instrumentalisé au profit du contrôle de l’immigration. Ces politiques grossissent les rangs des populations qui n’accèdent pas aux soins et doivent avoir recours à Médecins du ...

Are PEI-coated SWCNTs conjugated with hepatitis A virus? A chemical study with SEM, Z-potential, EDXD and RT-PCR

International Nuclear Information System (INIS)

Carbone, M; Valentini, F; Palleschi, G; Caminiti, R; Petrinca, A R; Donia, D; Divizia, M

2010-01-01

The conjugation between nanotubes, coated with different doses of polyethylene imine (PEI) and hepatitis A virus (HAV) was investigated by scanning electron microscopy, Z-potential, thermogravimetric and differential thermal analysis, transmission electron microscopy, energy dispersive x-ray diffraction (EDXD) and reverse transcript polymerase chain reaction (RT-PCR). For the first time, to our knowledge, evidence is obtained that conjugation between the nanotubes and the HAV occurs and that it has an (at least a partial) electrostatic character. Since all components of the conjugated systems, nanotubes, coating material and virus are characterized by different peak shapes in the selected q range, it was possible to infer that conjugation occurred. RT-PCR measurements confirmed that the conjugation of the coated nanotubes and HAV occurred and the result was stable. This opens up the prospect of probing the coated nanotubes as intra-cellular carriers in transfection processes of the virus. Further biological applications will concern a possible vaccine especially for non-replicative viruses.

Voice and Valency in San Luis Potosi Huasteco

Science.gov (United States)

Munoz Ledo Yanez, Veronica

2014-01-01

This thesis presents an analysis of the system of transitivity, voice and valency alternations in Huasteco of San Luis Potosi (Mayan) within a functional-typological framework. The study is based on spoken discourse and elicited data collected in the municipalities of Aquismon and Tancanhuitz de Santos in the state of San Luis Potosi, Mexico. The…

Timber resource statistics for the San Joaquin and southern resource areas of California.

Science.gov (United States)

Karen L. Waddell; Patricia M. Bassett

1997-01-01

This report is a summary of timber resource statistics for the San Joaquin and Southern Resource Areas of California, which include Alpine, Amador, Calaveras, Fresno, Imperial, Inyo, Kern, Kings, Los Angeles, Madera, Mariposa, Merced, Mono, Orange, Riverside, San Bernardino, San Diego, San Joaquin, Stanislaus, Tulare, and Tuolumne Counties. Data were collected as part...

The green areas of San Juan, Puerto Rico

Directory of Open Access Journals (Sweden)

Olga M. Ramos-González

2014-09-01

Full Text Available Green areas, also known as green infrastructure or urban vegetation, are vital to urbanites for their critical roles in mitigating urban heat island effects and climate change and for their provision of multiple ecosystem services and aesthetics. Here, I provide a high spatial resolution snapshot of the green cover distribution of the city of San Juan, Puerto Rico, by incorporating the use of morphological spatial pattern analysis (MSPA as a tool to describe the spatial pattern and connectivity of the city's urban green areas. Analysis of a previously developed IKONOS 4-m spatial resolution classification of the city of San Juan from 2002 revealed a larger area of vegetation (green areas or green infrastructure than previously estimated by moderate spatial resolution imagery. The city as a whole had approximately 42% green cover and 55% impervious surfaces. Although the city appeared greener in its southern upland sector compared to the northern coastal section, where most built-up urban areas occurred (66% impervious surfaces, northern San Juan had 677 ha more green area cover dispersed across the city than the southern component. MSPA revealed that most forest cover occurred as edges and cores, and green areas were most commonly forest cores, with larger predominance in the southern sector of the municipality. In dense, built-up, urban land, most of the green areas occurred in private yards as islets. When compared to other cities across the United States, San Juan was most similar in green cover features to Boston, Massachusetts, and Miami, Florida. Per capita green space for San Juan (122.2 m²/inhabitant was also comparable to these two U.S. cities. This study explores the intra-urban vegetation variation in the city of San Juan, which is generally overlooked by moderate spatial resolution classifications in Puerto Rico. It serves as a starting point for green infrastructure mapping and landscape pattern analysis of the urban green spaces

Biological contaminants and house characteristics : an interim analysis of data from the PEI study

Energy Technology Data Exchange (ETDEWEB)

Onysko, D.M. [DMO Associates (Canada); Ruest, K. [Canada Mortgage and Housing Corp., Ottawa, ON (Canada); Lawton, M. [Morrison Hershfield Ltd., Ottawa, ON (Canada); Miller, D. [Carleton Univ., Ottawa, ON (Canada); Fraser, B. [Jacques Whitford and Associates Limited, Ottawa, ON (Canada); Dale, R. [Health Canada, Ottawa, ON (Canada); Kazimierz, K.F.

2005-07-01

This paper discussed the results of a joint study on housing conditions, biological exposure and the health of infants in Prince Edward Island (PEI). The study was a longitudinal cohort investigation of the exposure of infants to biological materials in their home environments. Possible associations between housing data, biological data, operational circumstances and relevant family life style information were presented. A methodology of the study was presented, in which a total of 366 dwellings with newborn infants were monitored over a period of 6 years. All tests and inspections were presented, as well as the nature of variables in the study. House investigations included the following: housing and operational characteristics; variables related to the measure of molds in the air; mold areas as determined by visual inspection; the presence/absence of visible molds; past wetting events; and concentrations of endotoxins, ergosterol and allergens in various air and settled dust samples. It was concluded that there was support for the presumption that some housing characteristics were related to factors that may influence the health of occupants and their children. Moisture related concerns dominated the experimental design. Details of the following housing characteristics were summarized: ground moisture source coupling; operation of the residence by the occupant; analysis of dust samples; visible molds; and wetting events. It was concluded that further work is needed to review the final database in order to further correlate studies with the health of newborns who lived in the houses studied. 3 refs., 8 tabs., 4 figs.

Herbal medicine Guan Chang Fu Fang enhances 5-fluorouracil cytotoxicity and affects drug-associated genes in human colorectal carcinoma cells.

Science.gov (United States)

Yu, Chen; Liu, Shen-Lin; Qi, Ming-Hao; Zou, Xi; Wu, Jian; Zhang, Jing

2015-02-01

Guan Chang Fu Fang (GCFF) is a natural compound, which is extracted from three medicinal plants, Agrimonia pilosa Ledeb ., Patrinia scabiosaefolia and Solanum nigrum L . GCFF has demonstrated clinical efficacy in the treatment of colon cancer. At present, 5-fluorouracil (5-FU) is the primary active chemotherapeutic agent used for treating colon cancer. Using median-effect and apoptosis analyses, fluorescence microscopy and western blotting, the present study analyzed the association between GCFF and 5-FU in the human colon adenocarcinoma LoVo cell line. The effect of GCFF on the expression of chemotherapeutic agent-associated genes was also investigated. The results of the synergistic analysis revealed that GCFF exhibited a significant effect upon 5-FU-associated cytotoxicity within the LoVo cell line. This effect was observed over a broad dose-inhibition range (5-95%), but was particularly significant in the lower concentrations. The flow cytometry results revealed that low doses of GCFF or 5-FU induced S-phase arrest, as did a low-dose combination of the two drugs. After 48 h, GCFF significantly suppressed the expression levels of the chemotherapeutic agent resistance-associated genes within the colon cancer cells. The western blot analysis revealed that the combined effects of 5-FU and GCFF were due to a regulation of the B-cell lymphoma-2 family of proteins. The findings of the present study suggested that GCFF, when combined with 5-FU, has the potential to be a novel, chemotherapeutic compound for the treatment of colon cancer.

Sediment transport of streams tributary to San Francisco, San Pablo, and Suisun Bays, California, 1909-66

Science.gov (United States)

Porterfield, George

1980-01-01

A review of historical sedimentation data is presented, results of sediment-data collection for water years 1957-59 are summarized, and long-term sediment-discharge estimates from a preliminary report are updated. Comparison of results based on 3 years of data to those for the 10 water years, 1957-66, provides an indication of the adequacy of the data obtained during the short period to define the long-term relation between sediment transport and streamflow. During 1909-66, sediment was transported to the entire San Francisco Bay system at an average rate of 8.6 million cubic yards per year. The Sacramento and San Joaquin River basins provided about 83% of the sediment inflow to the system annually during 1957-66 and 86% during 1909-66. About 98% of this inflow was measured or estimated at sediment measuring sites. Measured sediment inflow directly to the bays comprised only about 40% of the total discharged by basins directly tributary to the bays. About 90% of the total sediment discharge to the delta and the bays in the San Francisco Bay system thus was determined on the basis of systematic measurements. (USGS)

San Andreas tremor cascades define deep fault zone complexity

Science.gov (United States)

Shelly, David R.

2015-01-01

Weak seismic vibrations - tectonic tremor - can be used to delineate some plate boundary faults. Tremor on the deep San Andreas Fault, located at the boundary between the Pacific and North American plates, is thought to be a passive indicator of slow fault slip. San Andreas Fault tremor migrates at up to 30 m s-1, but the processes regulating tremor migration are unclear. Here I use a 12-year catalogue of more than 850,000 low-frequency earthquakes to systematically analyse the high-speed migration of tremor along the San Andreas Fault. I find that tremor migrates most effectively through regions of greatest tremor production and does not propagate through regions with gaps in tremor production. I interpret the rapid tremor migration as a self-regulating cascade of seismic ruptures along the fault, which implies that tremor may be an active, rather than passive participant in the slip propagation. I also identify an isolated group of tremor sources that are offset eastwards beneath the San Andreas Fault, possibly indicative of the interface between the Monterey Microplate, a hypothesized remnant of the subducted Farallon Plate, and the North American Plate. These observations illustrate a possible link between the central San Andreas Fault and tremor-producing subduction zones.

Hydrologic assessment and numerical simulation of groundwater flow, San Juan Mine, San Juan County, New Mexico, 2010–13

Science.gov (United States)

Stewart, Anne M.

2018-04-03

Coal combustion byproducts (CCBs), which are composed of fly ash, bottom ash, and flue gas desulfurization material, produced at the coal-fired San Juan Generating Station (SJGS), located in San Juan County, New Mexico, have been buried in former surface-mine pits at the San Juan Mine, also referred to as the San Juan Coal Mine, since operations began in the early 1970s. This report, prepared by the U.S. Geological Survey in cooperation with the Mining and Minerals Division of the New Mexico Energy, Minerals and Natural Resources Department, describes results of a hydrogeologic assessment, including numerical groundwater modeling, to identify the timing of groundwater recovery and potential pathways for groundwater transport of metals that may be leached from stored CCBs and reach hydrologic receptors after operations cease. Data collected for the hydrologic assessment indicate that groundwater in at least one centrally located reclaimed surface-mining pit has already begun to recover.The U.S. Geological Survey numerical modeling package MODFLOW–NWT was used with MODPATH particle-tracking software to identify advective flow paths from CCB storage areas toward potential hydrologic receptors. Results indicate that groundwater at CCB storage areas will recover to the former steady state, or in some locations, groundwater may recover to a new steady state in 6,600 to 10,600 years at variable rates depending on the proximity to a residual cone-of-groundwater depression caused by mine dewatering and regional oil and gas pumping as well as on actual, rather than estimated, groundwater recharge and evapotranspirational losses. Advective particle-track modeling indicates that the number of particles and rates of advective transport will vary depending on hydraulic properties of the mine spoil, particularly hydraulic conductivity and porosity. Modeling results from the most conservative scenario indicate that particles can migrate from CCB repositories to either the

Effectiveness of Kampo medicine Gorei-san for chronic subdural hematoma

International Nuclear Information System (INIS)

Miyagami, Mitsusuke; Kagawa, Yukihide

2009-01-01

Chronic subdural hematomas (CSDHs) are basically treated by surgery. In some cases with no or minimum symptoms, however, they may be treated conservatively. In the present study, we evaluated the therapeutic effect of a Kampo medicine (Japanese traditional herbal medicine), Gorei-san, in the treatment of those CSDHs. Gorei-san 7.5 g t.i.d. was orally administered for 4 weeks in 22 patients with 27 CSDHs. Maximum thickness of the hematoma was followed up on CT scan for 4 to 29 weeks after administration of Gorei-san. In 7 of 22 patients, tranexamic acid and/or carbazochrome sodium sulfonate were also administrated. Gorei-san was effective in 23 of 27 CSDHs. In 12 of them, the hematoma was completely disappeared within 14 weeks after administration. In the other 11 CSDHs, the thickness was decreased. In those effective cases, thickness began to decrease 3 to 4 weeks after administration of Gorei-san. It was more effective in CSDHs with iso-/high or mixed density than with low density on CT. It was not effective in 4 out of 27 CSDHs. No apparent adverse effect was noted in the present series of patients. The present study suggests that a Kampo medicine, Gorei-san, is a useful option in the conservative treatment of CSDHs with no or minimum symptoms. (author)

75 FR 65985 - Safety Zone: Epic Roasthouse Private Party Firework Display, San Francisco, CA

Science.gov (United States)

2010-10-27

... the navigable waters of San Francisco Bay 1,000 yards off Epic Roasthouse Restaurant, San Francisco.... Wright, Program Manager, Docket Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: Regulatory... waters of San Francisco Bay, 1,000 yards off Epic Roasthouse Restaurant, San Francisco, CA. The fireworks...

75 FR 42014 - Proposed Amendment of Class E Airspace; San Clemente, CA

Science.gov (United States)

2010-07-20

...: Eldon Taylor, Federal Aviation Administration, Operations Support Group, Western Service Center, 1601... an extension to a Class D surface area, at San Clemente Island NALF (Fredrick Sherman Field), San... Clemente Island NALF (Fredrick Sherman Field), CA (Lat. 33[deg]01'22'' N., long. 118[deg]35'19'' W.) San...

78 FR 42027 - Safety Zone; San Diego Bayfair; Mission Bay, San Diego, CA

Science.gov (United States)

2013-07-15

... safety zones. Thunderboats Unlimited Inc. is sponsoring San Diego Bayfair, which is held on the navigable... distribution of power and responsibilities between the Federal Government and Indian tribes. 12. Energy Effects This proposed rule is not a ``significant energy action'' under Executive Order 13211, Actions...

Water absorption in PEEK and PEI matrices. Contribution to the understanding of water-polar group interactions

Science.gov (United States)

Courvoisier, E.; Bicaba, Y.; Colin, X.

2016-05-01

The water absorption in two aromatic linear polymers (PEEK and PEI) was studied between 10% and 90% RH at 30, 50 and 70°C. It was found that these polymers display classical Henry and Fick's behaviors. Moreover, they have very close values of equilibrium water concentration C∞ and water diffusivity D presumably because their respective polar groups establish molecular interactions of the same nature with water. This assumption was checked from a literature compilation of values of C∞ and D for a large variety of linear and tridimensional polymers containing a single type of polar group. It was then evidenced that almost all types of carbonyl group (in particular, those belonging to imides, amides and ketones) have the same molar contribution to water absorption, except those belonging to esters which are much less hydrophilic. Furthermore, hydroxyl and sulfone groups are much more hydrophilic than carbonyl groups so that their molar contribution is located on another master curve. On this basis, semi-empirical structure/water transport property relationships were proposed. It was found that C∞ increases exponentially with the concentration of polar groups (presumably because water is doubly bonded), but also with the intensity of their molecular interactions with water. In contrast, D is inversely proportional to C∞, which means that polar group-water interactions slow down the rate of water diffusion.

Chemical and Physical Characteristics of Pulverized Granitic Rock Adjacent to the San Andreas, Garlock and San Jacinto Faults: Implications for Earthquake Physics

Science.gov (United States)

Rockwell, T. K.; Sisk, M.; Stillings, M.; Girty, G.; Dor, O.; Wechsler, N.; Ben-Zion, Y.

2008-12-01

We present new detailed analyses of pulverized granitic rocks from sections adjacent to the San Andreas, Garlock and San Jacinto faults in southern California. Along the San Andreas and Garlock faults, the Tejon Lookout Granite is pulverized in all exposures within about 100 m of both faults. Along the Clark strand of the San Jacinto fault in Horse Canyon, the pulverization of granitic rocks is highly asymmetric, with a much broader zone of pulverization along the southwest side of the Clark fault. In areas where the granite is injected as dyke rock into schist, only the granitic rock shows pulverization, demonstrating the control of rock type on the pulverization process. Chemical analyses indicate little or no weathering in the bulk of the rock, although XRD analysis shows the presence of smectite, illite, and minor kaolinite in the clay-sized fraction. Weathering products may dominate in the less than 1 micron fraction. The average grain size in all samples of pulverized granitic rock range between about 20 and 200 microns (silt to fine sand), with the size distribution in part a function of proximity to the primary slip zone. The San Andreas fault samples are generally finer than those collected from along the Garlock or San Jacinto faults. The particle size distribution for all samples is non-fractal, with a distinct slope break in the 60-100 micron range, which suggests that pulverization is not a consequence of direct shear. This average particle size is quite coarser than previous reports, which we attribute to possible measurement errors in the prior work. Our data and observations suggest that dynamic fracturing in the wall rock of these three major faults only accounts for 1% or less of the earthquake energy budget.

77 FR 60897 - Safety Zone: America's Cup World Series Finish-Line, San Francisco, CA

Science.gov (United States)

2012-10-05

... navigable waters of the San Francisco Bay in vicinity of San Francisco West Yacht Harbor Light 2... vicinity of San Francisco West Yacht Harbor Light 2. Unauthorized persons or vessels are prohibited from... San Francisco West Yacht Harbor Light 2. This safety zone establishes a temporary restricted area on...

San Juanico Hybrid System Technical and Institutional Assessment: Preprint

Energy Technology Data Exchange (ETDEWEB)

Corbus, D.; Newcomb, C.; Yewdall, Z.

2004-07-01

San Juanico is a fishing village of approximately 120 homes in the Municipality of Comondu, Baja California. In April, 1999, a hybrid power system was installed in San Juanico to provide 24-hour power, which was not previously available. Before the installation of the hybrid power system, a field study was conducted to characterize the electrical usage and institutional and social framework of San Juanico. One year after the installation of the hybrid power system a''post-electrification'' study was performed to document the changes that had occurred after the installation. In December of 2003, NREL visited the site to conduct a technical assessment of the system.

Steam, solarization, and tons of prevention: the San Francisco Public Utilities Commission's fight to contain Phytophthoras in San Francisco Bay area restoration sites

Science.gov (United States)

Greg Lyman; Jessica Appel; Mia Ingolia; Ellen Natesan; Joe Ortiz

2017-01-01

To compensate for unavoidable impacts associated with critical water infrastructure capital improvement projects, the San Francisco Public Utilities Commission (SFPUC) restored over 2,050 acres of riparian, wetland, and upland habitat on watershed lands in Alameda, Santa Clara, and San Mateo Counties. Despite strict bio-sanitation protocols, plant pathogens (...

Effects of Choto-san (Diao-Teng-San) on microcirculation of bulbar conjunctiva and hemorheological factors in patients with asymptomatic cerebral infarction

OpenAIRE

YANG, Qiao; Kita, Toshiaki; Hikiami, Hiroaki; Shimada, Yutaka; Itoh, Takashi; Terasawa, Katsutoshi

1999-01-01

In this study, the effects of Choto-san ( 釣藤散 ) on the microcirculation of bulbar conjunctiva in 16 patients with asymptornatic cerebral infarction were investigated with a video-microscopic system. After the administration of Choto-san for four weeks, variables of microcirculatory flow of the bulbar conjunctiva, that is, the internal diameter of vessels, flow velocity and flow volume rate were increased (p

Riparian Habitat - San Joaquin River

Data.gov (United States)

California Natural Resource Agency — The immediate focus of this study is to identify, describe and map the extent and diversity of riparian habitats found along the main stem of the San Joaquin River,...

O fazer metodológico na educação de jovens e adultos: a prática no projeto educativo de integração social – PEIS/The methodological doing in the young and adults education...

Directory of Open Access Journals (Sweden)

Maria Fernanda P. Turina

2008-01-01

Full Text Available TURINA, M. F. P. O fazer metodológico na educação de jovens e adultos: a prática no projeto educativo de integração social – PEIS. 108fl. 2008. Dissertação (Mestrado em Educação – Faculdade de Educação, Universidade Estadual de Campinas, Campinas. 2008.

Neutron beam applications - Polymer study and sample environment development for HANARO SANS instrument

Energy Technology Data Exchange (ETDEWEB)

Kim, Hong Doo [Kyunghee University, Seoul (Korea); Char, Kook Heon [Seoul National University, Seoul (Korea)

2000-04-01

A new SANS instrument will be installed in HANARO reactor near future and in parallel it is necessary to develop the sample environment facilities. One of the basic items is the equipment to control the sample temperature of cell block with auto-sample changer. It is required to develop a control software for this purpose. In addition, softwares of the aquisition and analysis for SANS instrument must be developed and supplied in order to function properly. PS/PI block copolymer research in NIST will provide the general understanding of SANS instrument and instrument-related valuable informations such as standard sample for SANS and know-hows of the instrument building. The following are the results of this research. a. Construction of sample cell block. b. Software to control the temperature and auto-sample changer. c. Acquisition of the SANS data analysis routine and its modification for HANARO SANS. d. PS/PI block copolymer research in NIST. e. Calibration data of NIST and HANARO SANS for comparison. 39 figs., 2 tabs. (Author)

33 CFR 80.1130 - San Luis Obispo Bay, CA.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false San Luis Obispo Bay, CA. 80.1130 Section 80.1130 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1130 San Luis Obispo Bay, CA. A line drawn from...

San Antonio Bay 1986-1989

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The effect of salinity on utilization of shallow-water nursery habitats by aquatic fauna was assessed in San Antonio Bay, Texas. Overall, 272 samples were collected...

San Gregorio mining: general presentation of the enterprise

International Nuclear Information System (INIS)

1997-01-01

This work is a project presented by San Gregorio Mine.This company is responsible for the extraction and gold ore deposits benefits in San Gregorio and East extension in Minas de Corrales. For this project was carried out an environmental impact study as well as and agreement with the LATU for the laboratory analyzes and the surface and groundwater monitoring within the Environmental program established by the Company

Estimating natural recharge in San Gorgonio Pass watersheds, California, 1913–2012

Science.gov (United States)

Hevesi, Joseph A.; Christensen, Allen H.

2015-12-21

A daily precipitation-runoff model was developed to estimate spatially and temporally distributed recharge for groundwater basins in the San Gorgonio Pass area, southern California. The recharge estimates are needed to define transient boundary conditions for a groundwater-flow model being developed to evaluate the effects of pumping and climate on the long-term availability of groundwater. The area defined for estimating recharge is referred to as the San Gorgonio Pass watershed model (SGPWM) and includes three watersheds: San Timoteo Creek, Potrero Creek, and San Gorgonio River. The SGPWM was developed by using the U.S. Geological Survey INFILtration version 3.0 (INFILv3) model code used in previous studies of recharge in the southern California region, including the San Gorgonio Pass area. The SGPWM uses a 150-meter gridded discretization of the area of interest in order to account for spatial variability in climate and watershed characteristics. The high degree of spatial variability in climate and watershed characteristics in the San Gorgonio Pass area is caused, in part, by the high relief and rugged topography of the area.

Timber resource statistics for the San Joaquin and southern California resource areas.

Science.gov (United States)

Bruce Hiserote; Joel Moen; Charles L. Bolsinger

1986-01-01

This report is one of five that provide timber resource statistics for 57 of the 58 counties in California (San Francisco is excluded). This report presents statistics from a 1982-84 inventory of the timber resources of Alpine, Amador, Calaveras, Fresno, Imperial, Inyo, Kern, Kings, Los Angeles, Madera, Mariposa, Merced, Mono, Orange, Riverside, San Bernardino, San...

A simulation of the San Andreas fault experiment

Science.gov (United States)

Agreen, R. W.; Smith, D. E.

1974-01-01

The San Andreas fault experiment (Safe), which employs two laser tracking systems for measuring the relative motion of two points on opposite sides of the fault, has been simulated for an 8-yr observation period. The two tracking stations are located near San Diego on the western side of the fault and near Quincy on the eastern side; they are roughly 900 km apart. Both will simultaneously track laser reflector equipped satellites as they pass near the stations. Tracking of the Beacon Explorer C spacecraft has been simulated for these two stations during August and September for 8 consecutive years. An error analysis of the recovery of the relative location of Quincy from the data has been made, allowing for model errors in the mass of the earth, the gravity field, solar radiation pressure, atmospheric drag, errors in the position of the San Diego site, and biases and noise in the laser systems. The results of this simulation indicate that the distance of Quincy from San Diego will be determined each year with a precision of about 10 cm. Projected improvements in these model parameters and in the laser systems over the next few years will bring the precision to about 1-2 cm by 1980.

75 FR 39166 - Safety Zone; San Francisco Giants Baseball Game Promotion, San Francisco, CA

Science.gov (United States)

2010-07-08

... San Francisco, CA. The fireworks display is meant for entertainment purposes. This safety zone is... National Technology Transfer and Advancement Act (NTTAA) (15 U.S.C. 272 note) directs agencies to use...), of the Instruction. This rule involves establishing, disestablishing, or changing Regulated...

SANS-1 Experimental reports of 2000

International Nuclear Information System (INIS)

Willumeit, R.; Haramus, V.

2001-01-01

The instrument SANS-1 at the Geesthacht neutron facility GeNF was used for scattering experiments in 2000 at 196 of 200 days of reactor and cold source operation. The utilisation was shared between the in-house R and D program and user groups from different universities and research centers. These measurements were performed and analysed either by guest scientists or GKSS staff. The focus of the work in 2000 at the experiment SANS-1 was the structural investigation of hydrogen containing substances such as biological macromolecules (ribosomes, protein-RNA-complexes, protein solutions, glycolipids and membranes), molecules which are important in the fields of environmental research (refractoric organic substances) and technical chemistry (surfactants, micelles). (orig.) [de

SANS studies of solutions and molecular composites prepared from cellulose tricarbanilate

CERN Document Server

Alava, C; Cameron, J D; Cowie, J M G; Vaqueiro, P; Möller, A; Triolo, A

2002-01-01

We report on SANS measurements carried out on the instrument SANS1 (V4) at the BENSC facility on solutions and composites of cellulose tricarbanilate (CTC). This cellulose derivative exhibits lyotropic behaviour in methylacrylate (MA). The SANS data indicate that in the isotropic liquid state (up to 25% wt CTC in MA) the CTC chains behave like rods of mass per unit length (M/L). In the liquid crystalline (LC) phase (at and above 35% wt CTC in MA), the Q dependence varies from Q sup - sup 1 to Q sup - sup 4 , probably as a result of self-assembling of the CTC chains. The general aim of our work is to prepare molecular composites, i.e. miscible blends of rigid-rod and flexible-coil polymers, from CTC solutions in polymerizable media. To establish the degree of homogeneity of the composites, we performed SANS measurements on UV-cured CTC/MA solutions. Here, we compare the SANS data of CTC/monomer solutions with those of the corresponding composites. (orig.)

78 FR 35593 - Special Local Regulation; Christmas Boat Parade, San Juan Harbor; San Juan, PR

Science.gov (United States)

2013-06-13

... individually or cumulatively have a significant effect on the human environment. This proposed rule involves.... Pearson, Captain, U.S. Coast Guard, Captain of the Port San Juan. [FR Doc. 2013-13994 Filed 6-12-13; 8:45...

76 FR 6517 - San Luis & Rio Grande Railroad-Petition for a Declaratory Order

Science.gov (United States)

2011-02-04

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35380] San Luis & Rio... petition filed by San Luis & Rio Grande Railroad (SLRG), the Board instituted a declaratory order... proposed operation of a truck-to-rail transload facility in Antonito, Colorado. See San Luis & Rio Grande R...

New evidence on the state of stress of the san andreas fault system.

Science.gov (United States)

Zoback, M D; Zoback, M L; Mount, V S; Suppe, J; Eaton, J P; Healy, J H; Oppenheimer, D; Reasenberg, P; Jones, L; Raleigh, C B; Wong, I G; Scotti, O; Wentworth, C

1987-11-20

Contemporary in situ tectonic stress indicators along the San Andreas fault system in central California show northeast-directed horizontal compression that is nearly perpendicular to the strike of the fault. Such compression explains recent uplift of the Coast Ranges and the numerous active reverse faults and folds that trend nearly parallel to the San Andreas and that are otherwise unexplainable in terms of strike-slip deformation. Fault-normal crustal compression in central California is proposed to result from the extremely low shear strength of the San Andreas and the slightly convergent relative motion between the Pacific and North American plates. Preliminary in situ stress data from the Cajon Pass scientific drill hole (located 3.6 kilometers northeast of the San Andreas in southern California near San Bernardino, California) are also consistent with a weak fault, as they show no right-lateral shear stress at approximately 2-kilometer depth on planes parallel to the San Andreas fault.

Screening and characterization of ethanol-tolerant and thermotolerant acetic acid bacteria from Chinese vinegar Pei.

Science.gov (United States)

Chen, Yang; Bai, Ye; Li, Dongsheng; Wang, Chao; Xu, Ning; Hu, Yong

2016-01-01

Acetic acid bacteria (AAB) are important microorganisms in the vinegar industry. However, AAB have to tolerate the presence of ethanol and high temperatures, especially in submerged fermentation (SF), which inhibits AAB growth and acid yield. In this study, seven AAB that are tolerant to temperatures above 40 °C and ethanol concentrations above 10% (v/v) were isolated from Chinese vinegar Pei. All the isolated AAB belong to Acetobacter pasteurianus according to 16S rDNA analysis. Among all AAB, AAB4 produced the highest acid yield under high temperature and ethanol test conditions. At 4% ethanol and 30-40 °C temperatures, AAB4 maintained an alcohol-acid transform ratio of more than 90.5 %. High alcohol-acid transform ratio was still maintained even at higher temperatures, namely, 87.2, 77.1, 14.5 and 2.9% at 41, 42, 43 and 44 °C, respectively. At 30 °C and different initial ethanol concentrations (4-10%), the acid yield by AAB4 increased gradually, although the alcohol-acid transform ratio decreased to some extent. However, 46.5, 8.7 and 0.9% ratios were retained at ethanol concentrations of 11, 12 and 13%, respectively. When compared with AS1.41 (an AAB widely used in China) using a 10 L fermentor, AAB4 produced 42.0 g/L acetic acid at 37 °C with 10% ethanol, whereas AS1.41 almost stopped producing acetic acid. In conclusion, these traits suggest that AAB4 is a valuable strain for vinegar production in SF.

Dal "San Marco" al "Vega". (English Title: From "San Marco" to Vega)

Science.gov (United States)

Savi, E.

2017-10-01

Apart from the two superpowers, among the other countries Italy has had an important role in astronautics. The roots of Italian astronautics' history runs deep in the hottest years of the Cold War, and it had its first remarkable achievement in the San Marco project..after years of advanced technologies testing, they achieved European cooperation and built VEGA, the current Arianespace light launcher.

Relocating San Miguel Volcanic Seismic Events for Receiver Functions and Tomographic Models

Science.gov (United States)

Patlan, E.; Velasco, A. A.; Konter, J.

2009-12-01

The San Miguel volcano lies near the city of San Miguel, El Salvador (13.43N and -88.26W). San Miguel volcano, an active stratovolcano, presents a significant natural hazard for the city of San Miguel. Furthermore, the internal state and activity of volcanoes remains an important component to understanding volcanic hazard. The main technology for addressing volcanic hazards and processes is through the analysis of data collected from the deployment of seismic sensors that record ground motion. Six UTEP seismic stations were deployed around San Miguel volcano from 2007-2008 to define the magma chamber and assess the seismic and volcanic hazard. We utilize these data to develop images of the earth structure beneath the volcano, studying the volcanic processes by identifying different sources, and investigating the role of earthquakes and faults in controlling the volcanic processes. We will calculate receiver functions to determine the thickness of San Miguel volcano internal structure, within the Caribbean plate. Crustal thicknesses will be modeled using calculated receiver functions from both theoretical and hand-picked P-wave arrivals. We will use this information derived from receiver functions, along with P-wave delay times, to map the location of the magma chamber.

El círculo meridiano automático de San Fernando - San Juan. Sus primeros pasos en el hemisferio sur

Science.gov (United States)

Mallamaci, C. C.; Muiños, J. L.; Gallego, M.; Pérez, J. A.; Marmolejo, L.; Navarro, J. L.; Sedeño, J.; Vallejos, M.; Belizón, F.

Se informa sobre el estado actual del Círculo Meridiano Automático de San Fernando-San Juan. El instrumento (Grubb-Parson, de 178mm de abertura y 2665 mm de distancia focal) es gemelo del que se encuentra en las Islas Canarias, y fue instalado durante los meses de julio y agosto de 1996 en la estación astronómica ``Dr. C.U.Cesco" (El Leoncito, Barreal), a unos 200 km de distancia de la ciudad de San Juan, merced a un Convenio de Cooperación Científica, firmado en 1994 entre el ROA (España) y el OAFA (Argentina). En la actualidad se está llevando a cabo un programa de prueba cuyos resultados preliminares muestran que el telescopio está en buenas condiciones para observar estrellas de hasta magnitud aproximada 14.5, con buenos errores de observación (<0.12" en ascensión recta y declinación).

California State Waters Map Series: offshore of San Gregorio, California

Science.gov (United States)

Cochrane, Guy R.; Dartnell, Peter; Greene, H. Gary; Watt, Janet T.; Golden, Nadine E.; Endris, Charles A.; Phillips, Eleyne L.; Hartwell, Stephen R.; Johnson, Samuel Y.; Kvitek, Rikk G.; Erdey, Mercedes D.; Bretz, Carrie K.; Manson, Michael W.; Sliter, Ray W.; Ross, Stephanie L.; Dieter, Bryan E.; Chin, John L.; Cochran, Susan A.; Cochrane, Guy R.; Cochran, Susan A.

2014-01-01

In 2007, the California Ocean Protection Council initiated the California Seafloor Mapping Program (CSMP), designed to create a comprehensive seafloor map of high-resolution bathymetry, marine benthic habitats, and geology within the 3-nautical-mile limit of California's State Waters. The CSMP approach is to create highly detailed seafloor maps through collection, integration, interpretation, and visualization of swath sonar data, acoustic backscatter, seafloor video, seafloor photography, high-resolution seismic-reflection profiles, and bottom-sediment sampling data. The map products display seafloor morphology and character, identify potential marine benthic habitats, and illustrate both the surficial seafloor geology and shallow (to about 100 m) subsurface geology. The Offshore of San Gregorio map area is located in northern California, on the Pacific coast of the San Francisco Peninsula about 50 kilometers south of the Golden Gate. The map area lies offshore of the Santa Cruz Mountains, part of the northwest-trending Coast Ranges that run roughly parallel to the San Andreas Fault Zone. The Santa Cruz Mountains lie between the San Andreas Fault Zone and the San Gregorio Fault system. The nearest significant onshore cultural centers in the map area are San Gregorio and Pescadero, both unincorporated communities with populations well under 1,000. Both communities are situated inland of state beaches that share their names. No harbor facilities are within the Offshore of San Gregorio map area. The hilly coastal area is virtually undeveloped grazing land for sheep and cattle. The coastal geomorphology is controlled by late Pleistocene and Holocene slip in the San Gregorio Fault system. A westward bend in the San Andreas Fault Zone, southeast of the map area, coupled with right-lateral movement along the San Gregorio Fault system have caused regional folding and uplift. The coastal area consists of high coastal bluffs and vertical sea cliffs. Coastal promontories in

Characterization of alumina using small angle neutron scattering (SANS)

International Nuclear Information System (INIS)

Megat Harun Al Rashidn Megat Ahmad; Abdul Aziz Mohamed; Azmi Ibrahim; Che Seman Mahmood; Edy Giri Rachman Putra; Muhammad Rawi Muhammad Zin; Razali Kassim; Rafhayudi Jamro

2007-01-01

Alumina powder was synthesized from an aluminium precursor and studied using small angle neutron scattering (SANS) technique and complemented with transmission electron microscope (TEM). XRD measurement confirmed that the alumina produced was high purity and highly crystalline αphase. SANS examination indicates the formation of mass fractals microstructures with fractal dimension of about 2.8 on the alumina powder. (Author)

Species - San Diego Co. [ds121

Data.gov (United States)

California Natural Resource Agency — This is the Biological Observation Database point layer representing baseline observations of sensitive species (as defined by the MSCP) throughout San Diego County....

Lipid based drug delivery systems: Kinetics by SANS

Science.gov (United States)

Uhríková, D.; Teixeira, J.; Hubčík, L.; Búcsi, A.; Kondela, T.; Murugova, T.; Ivankov, O. I.

2017-05-01

N,N-dimethyldodecylamine-N-oxide (C12NO) is a surfactant that may exist either in a neutral or protonated form depending on the pH of aqueous solutions. Using small angle X-ray diffraction (SAXD) we demonstrate structural responsivity of C12NO/dioleoylphospha-tidylethanolamine (DOPE)/DNA complexes designed as pH sensitive gene delivery vectors. Small angle neutron scattering (SANS) was employed to follow kinetics of C12NO protonization and DNA binding into C12NO/DOPE/DNA complexes in solution of 150 mM NaCl at acidic condition. SANS data analyzed using paracrystal lamellar model show the formation of complexes with stacking up to ∼32 bilayers, spacing ∼ 62 Å, and lipid bilayer thickness ∼37 Å in 3 minutes after changing pH from 7 to 4. Subsequent structural reorganization of the complexes was observed along 90 minutes of SANS mesurements.

Lipid based drug delivery systems: Kinetics by SANS

International Nuclear Information System (INIS)

Uhríková, D; Hubčík, L; Búcsi, A; Kondela, T; Teixeira, J; Murugova, T; Ivankov, O I

2017-01-01

N,N-dimethyldodecylamine-N-oxide (C 12 NO) is a surfactant that may exist either in a neutral or protonated form depending on the pH of aqueous solutions. Using small angle X-ray diffraction (SAXD) we demonstrate structural responsivity of C 12 NO/dioleoylphospha-tidylethanolamine (DOPE)/DNA complexes designed as pH sensitive gene delivery vectors. Small angle neutron scattering (SANS) was employed to follow kinetics of C 12 NO protonization and DNA binding into C 12 NO/DOPE/DNA complexes in solution of 150 mM NaCl at acidic condition. SANS data analyzed using paracrystal lamellar model show the formation of complexes with stacking up to ∼32 bilayers, spacing ∼ 62 Å, and lipid bilayer thickness ∼37 Å in 3 minutes after changing pH from 7 to 4. Subsequent structural reorganization of the complexes was observed along 90 minutes of SANS mesurements. (paper)

Geologic Map of the San Luis Quadrangle, Costilla County, Colorado

Science.gov (United States)

Machette, Michael N.; Thompson, Ren A.; Drenth, Benjamin J.

2008-01-01

The map area includes San Luis and the primarily rural surrounding area. San Luis, the county seat of Costilla County, is the oldest surviving settlement in Colorado (1851). West of the town are San Pedro and San Luis mesas (basalt-covered tablelands), which are horsts with the San Luis fault zone to the east and the southern Sangre de Cristo fault zone to the west. The map also includes the Sanchez graben (part of the larger Culebra graben), a deep structural basin that lies between the San Luis fault zone (on the west) and the central Sangre de Cristo fault zone (on the east). The oldest rocks exposed in the map area are the Pliocene to upper Oligocene basin-fill sediments of the Santa Fe Group, and Pliocene Servilleta Basalt, a regional series of 3.7?4.8 Ma old flood basalts. Landslide deposits and colluvium that rest on sediments of the Santa Fe Group cover the steep margins of the mesas. Rare exposures of the sediment are comprised of siltstones, sandstones, and minor fluvial conglomerates. Most of the low ground surrounding the mesas and in the graben is covered by surficial deposits of Quaternary age. The alluvial deposits are subdivided into three Pleistocene-age units and three Holocene-age units. The oldest Pleistocene gravel (unit Qao) forms extensive coalesced alluvial fan and piedmont surfaces, the largest of which is known as the Costilla Plain. This surface extends west from San Pedro Mesa to the Rio Grande. The primary geologic hazards in the map area are from earthquakes, landslides, and localized flooding. There are three major fault zones in the area (as discussed above), and they all show evidence for late Pleistocene to possible Holocene movement. The landslides may have seismogenic origins; that is, they may be stimulated by strong ground shaking during large earthquakes. Machette and Thompson based this geologic map entirely on new mapping, whereas Drenth supplied geophysical data and interpretations.

33 CFR 165.758 - Security Zone; San Juan, Puerto Rico.

Science.gov (United States)

2010-07-01

... Security Zone; San Juan, Puerto Rico. (a) Location. Moving and fixed security zones are established 50... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; San Juan, Puerto Rico. 165.758 Section 165.758 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

Resistance Management for San Jose Scale (Hemiptera: Diaspididae).

Science.gov (United States)

Buzzetti, K; Chorbadjian, R A; Nauen, R

2015-12-01

The San Jose scale Diaspidiotus perniciosus Comstock is one of the most important pests of deciduous fruit trees. The major cause of recent outbreaks in apple orchards is thought to be the development of insecticide resistance, specifically organophosphates. The first report was given in North America, and now, in Chile. In the present study, San Jose scale populations collected from two central regions of Chile were checked for their susceptibility to different mode of action insecticides in order to establish alternatives to manage this pest. No evidence of cross resistance between organophosphates insecticides and acetamiprid, buprofezin, pyriproxyfen, spirotetramat, sulfoxaflor, or thiacloprid was found. Baselines of LC50-LC95 for different life stages of San Jose scale are given, as reference to future studies of resistance monitoring. The systemic activity of acetamiprid, spirotetramat, and thiacloprid was higher than the contact residue effect of these compounds. For sulfoxaflor, both values were similar. Program treatments including one or more of these compounds are compared in efficacy and impact on resistance ratio values. In order to preserve new insecticides as an important tool to control San Jose scale, resistance management programs should be implemented, considering insecticide mode of action classes alternated or mixed. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

A new record for American Bullfrog (Lithobates catesbeianus in San Juan, Argentina Nuevo registro de rana toro americana (Lithobates catesbeianus en San Juan, Argentina

Directory of Open Access Journals (Sweden)

Eduardo Sanabria

2011-03-01

Full Text Available We report a new record of Lithobates catesbeianus (American bullfrog from Argentina. L. catesbeianus was first introduced to San Juan Province 11 years ago in Calingasta Department, where the habitat is pre-cordilleran. The new record is for Zonda Department, San Juan Province, in the Monte desert region. Here, L. catesbeianus uses artificial ponds for reproduction and tadpole development. These ponds receive water from an irrigation system that connects the whole agriculture land in the region. The tadpoles use the irrigation canals to move among ponds. We suggest that legislation should be established to prevent future invasions and to achieve sustainable management of the wild American bullfrog populations in San Juan. Prevention of future invasion and management of established populations of this species requires the cooperation of numerous stake holders.Se presenta un nuevo registro de Lithobates catesbeianus (rana toro americana en Argentina. L. catesbeianus fue introducida por primera vez a la provincia de San Juan hace 11 años en el Departamento Calingasta, donde el hábitat es pre-cordillerano. El nuevo registro es para el Departamento Zonda en la provincia de San Juan, en el desierto del Monte. En este sitio, L. catesbeianus usa estanques artificiales para la reproducción y desarrollo del renacuajo. Los estanques reciben agua de un sistema de riego que conecta todas las tierras de la agricultura en la región. Los renacuajos utilizan los canales de riego para moverse entre los estanques. Sugerimos que se establezcan leyes para prevenir invasiones futuras y para lograr un manejo integrado de las poblaciones silvestres de rana toro que se encuentran en San Juan. La prevención de futuras invasiones y el manejo de las poblaciones establecidas de esta especie requieren la cooperación de numerosas entidades tanto gubernamentales como privadas.

Structure of the 1906 near-surface rupture zone of the San Andreas Fault, San Francisco Peninsula segment, near Woodside, California

Science.gov (United States)

Rosa, C.M.; Catchings, R.D.; Rymer, M.J.; Grove, Karen; Goldman, M.R.

2016-07-08

High-resolution seismic-reflection and refraction images of the 1906 surface rupture zone of the San Andreas Fault near Woodside, California reveal evidence for one or more additional near-surface (within about 3 meters [m] depth) fault strands within about 25 m of the 1906 surface rupture. The 1906 surface rupture above the groundwater table (vadose zone) has been observed in paleoseismic trenches that coincide with our seismic profile and is seismically characterized by a discrete zone of low P-wave velocities (Vp), low S-wave velocities (Vs), high Vp/Vs ratios, and high Poisson’s ratios. A second near-surface fault strand, located about 17 m to the southwest of the 1906 surface rupture, is inferred by similar seismic anomalies. Between these two near-surface fault strands and below 5 m depth, we observed a near-vertical fault strand characterized by a zone of high Vp, low Vs, high Vp/Vs ratios, and high Poisson’s ratios on refraction tomography images and near-vertical diffractions on seismic-reflection images. This prominent subsurface zone of seismic anomalies is laterally offset from the 1906 surface rupture by about 8 m and likely represents the active main (long-term) strand of the San Andreas Fault at 5 to 10 m depth. Geometries of the near-surface and subsurface (about 5 to 10 m depth) fault zone suggest that the 1906 surface rupture dips southwestward to join the main strand of the San Andreas Fault at about 5 to 10 m below the surface. The 1906 surface rupture forms a prominent groundwater barrier in the upper 3 to 5 m, but our interpreted secondary near-surface fault strand to the southwest forms a weaker barrier, suggesting that there has been less or less-recent near-surface slip on that strand. At about 6 m depth, the main strand of the San Andreas Fault consists of water-saturated blue clay (collected from a hand-augered borehole), which is similar to deeply weathered serpentinite observed within the main strand of the San Andreas Fault at

New fault picture points toward San Francisco Bay area earthquakes

Science.gov (United States)

Kerr, R. A.

1989-01-01

Recent earthquakes and a new way of looking at faults suggest that damaging earthquakes are closing in on the San Francisco area. Earthquakes Awareness Week 1989 in northern California started off with a bang on Monday, 3 April, when a magnitude 4.8 earthquake struck 15 kilometers northeast of San Jose. The relatively small shock-its primary damage was the shattering of an air-control tower window-got the immediate attention of three U.S Geological Survey seismologists in Menlo Park near San Francisco. David Oppenheimer, William Bakun, and Allan Lindh had forecast a nearby earthquake in a just completed report, and this, they thought, might be it. 

The San values of conflict prevention and avoidance in Platfontein

Directory of Open Access Journals (Sweden)

Nina Mollema

2017-09-01

Full Text Available The aim of this article is to identify measures that can prevent violent conflict through the maintenance of traditional cultural values that guide conflict avoidance. Moreover, the article focuses on the concepts of conflict prevention and conflict avoidance as applied by the San community of Platfontein. The causes of the inter-communal tensions between the San community members are also examined. A selected conflict situation, that of superstition and witchcraft, is assessed as factors increasing interpersonal conflict in the Platfontein community. This investigation is made to determine if the San preventive measures have an impact in the community, so as to prevent ongoing conflicts from escalating further.

El castillo de San Romualdo (San Fernando, Cádiz. Aproximación estratigráfica y evolución constructiva

Directory of Open Access Journals (Sweden)

Utrera Burgal, Raquel M.

2009-12-01

Full Text Available This article shows the results of the archaeological research carried out in the castle of San Romualdo, the most emblematic building of the city of San Fernando and a defensive fortress tied to the control access of Cádiz. The standing building recording has enabled to know the building evolution from its origins until the present. Studies have hitherto confirmed the chronological conclusions already proposed in 2003. That is, the current castle is a medieval Christian building erected in the second half of the 13th century thanks to Mudejar workers and materials reused from a previous building.Presentamos en este artículo los resultados de nuestra investigación arqueológica en el castillo de San Romualdo, el edificio más emblemático de la ciudad de San Fernando y fortaleza defensiva ligada al control del acceso a Cádiz. El análisis estratigráfico de alzados ha permitido conocer la evolución constructiva del edificio, desde sus orígenes hasta la actualidad. Hasta ahora los estudios confirman las conclusiones en cuanto a su datación presentadas en el año 2003, es decir, el castillo, tal y como hoy lo conocemos, es una construcción medieval cristiana, realizada durante la segunda mitad del siglo XIII, con mano de obra mudéjar y con materiales reutilizados de una edificación anterior.

The San Diego Panasonic Partnership: A Case Study in Restructuring.

Science.gov (United States)

Holzman, Michael; Tewel, Kenneth J.

1992-01-01

The Panasonic Foundation provides resources for restructuring school districts. The article examines its partnership with the San Diego City School District, highlighting four schools that demonstrate promising practices and guiding principles. It describes recent partnership work on systemic issues, noting the next steps to be taken in San Diego.…

Characterizing the Organic Matter in Surface Sediments from the San Juan Bay Estuary,

Science.gov (United States)

The San Juan Bay Estuary (SJBE) is located on the north coast of Puerto Rico and includes the San Juan Bay, San José Lagoon, La Torrecilla Lagoon and Piñones Lagoon, as well as the Martín Peña and the Suárez Canals. The SJBE watershed has the highest...

Cuartel San Carlos. Yacimiento veterano

Directory of Open Access Journals (Sweden)

Mariana Flores

2007-01-01

Full Text Available El Cuartel San Carlos es un monumento histórico nacional (1986 de finales del siglo XVIII (1785-1790, caracterizado por sufrir diversas adversidades en su construcción y soportar los terremotos de 1812 y 1900. En el año 2006, el organismo encargado de su custodia, el Instituto de Patrimonio Cultural del Ministerio de Cultura, ejecutó tres etapas de exploración arqueológica, que abarcaron las áreas Traspatio, Patio Central y las Naves Este y Oeste de la edificación. Este trabajo reseña el análisis de la documentación arqueológica obtenida en el sitio, a partir de la realización de dicho proyecto, denominado EACUSAC (Estudio Arqueológico del Cuartel San Carlos, que representa además, la tercera campaña realizada en el sitio. La importancia de este yacimiento histórico, radica en su participación en los acontecimientos que propiciaron conflictos de poder durante el surgimiento de la República y en los sucesos políticos del siglo XX. De igual manera, se encontró en el sitio una amplia muestra de materiales arqueológicos que reseñan un estilo de vida cotidiana militar, así como las dinámicas sociales internas ocurridas en el San Carlos, como lugar estratégico para la defensa de los diferentes regímenes que atravesó el país, desde la época del imperialismo español hasta nuestros días.

San Francisco urban partnership agreement, national evaluation : exogenous factors test plan.

Science.gov (United States)

2011-06-01

This report presents the test plan for collecting and analyzing exogenous factors data for the San Francisco Urban : Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. : The San Francisco UPA proj...

Data Files for Ground-Motion Simulations of the 1906 San Francisco Earthquake and Scenario Earthquakes on the Northern San Andreas Fault

Science.gov (United States)

Aagaard, Brad T.; Barall, Michael; Brocher, Thomas M.; Dolenc, David; Dreger, Douglas; Graves, Robert W.; Harmsen, Stephen; Hartzell, Stephen; Larsen, Shawn; McCandless, Kathleen; Nilsson, Stefan; Petersson, N. Anders; Rodgers, Arthur; Sjogreen, Bjorn; Zoback, Mary Lou

2009-01-01

This data set contains results from ground-motion simulations of the 1906 San Francisco earthquake, seven hypothetical earthquakes on the northern San Andreas Fault, and the 1989 Loma Prieta earthquake. The bulk of the data consists of synthetic velocity time-histories. Peak ground velocity on a 1/60th degree grid and geodetic displacements from the simulations are also included. Details of the ground-motion simulations and analysis of the results are discussed in Aagaard and others (2008a,b).

Determination of the phytochemical composition of Jingning fang and the in vivo pharmacokinetics of its metabolites in rat plasma by UPLC-MS/MS.

Science.gov (United States)

Yang, Chunjing; Yin, XingBin; Dong, Xiaoxv; Zhang, Xin; You, Longtai; Wang, Wenping; Wang, Junhong; Chen, Qinghe; Ni, Jian

2017-11-01

Jingning fang (JNF) is an effective Traditional Chinese Medicine (TCM) which is used for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). To clarify the bioactive constituents of JNF, a Thermo Q Exactive™ Plus Orbitrap™ mass spectrometer was used in this study. More than 127 chemical compounds were isolated and identified tentatively in the JNF extract, while 42 prototype constituents with 4 potential metabolites were identified tentatively in rat plasma. A method for simultaneous determination of polygalaxanthone III (PAIII), sibiricose A 5 (A 5 ), sibiricose A 6 (A 6 ), 3, 6'-disinapoyl sucrose (3,6'-DISS), tenuifoliside C (TEC), tenuifolin B (TNB), verbascoside (VCE), heterophyllin B (HEB) and schisandrin (SCH) in rat was developed and validated using polydatin (PLN) and psoralen (PSN) as internal standards. All calibration curves proved favorable linearity (R 2 ≥0.9923) in linear ranges. The lower limit of quantification (LLOQ) was 2.5ng/mL for PAIII, A 5 , 3, 6'-DISS, TNB, VCE, HEB and SCH, 1.0ng/mL for A 6 and TEC, respectively. Intra-day and inter-day precisions didn't exceed 14.0% for all the analytes. Extraction recoveries and matrix effects of analytes and IS were acceptable. The validated method has been successfully applied to the pharmacokinetics (PK) studies of the nine compounds in JNF. These findings are useful for predicting the bioactive components of JNF, and will aid in optimizing dose regimens of the drug. Copyright © 2017. Published by Elsevier B.V.

San Francisco Bay Water Quality Improvement Fund Map Service, San Francisco CA, 2012, US EPA Region 9

Data.gov (United States)

U.S. Environmental Protection Agency — The San Francisco Bay Water Quality Improvement Fund is a competitive grant program that is helping implement TMDLs to improve water quality, protect wetlands, and...

San Francisco Bay Water Quality Improvement Fund Project Locations, San Francisco CA, 2017, US EPA Region 9

Data.gov (United States)

U.S. Environmental Protection Agency — The San Francisco Bay Water Quality Improvement Fund is a competitive grant program that is helping implement TMDLs to improve water quality, protect wetlands, and...

An overview of San Francisco Bay PORTS

Science.gov (United States)

Cheng, Ralph T.; McKinnie, David; English, Chad; Smith, Richard E.

1998-01-01

The Physical Oceanographic Real-Time System (PORTS) provides observations of tides, tidal currents, and meteorological conditions in real-time. The San Francisco Bay PORTS (SFPORTS) is a decision support system to facilitate safe and efficient maritime commerce. In addition to real-time observations, SFPORTS includes a nowcast numerical model forming a San Francisco Bay marine nowcast system. SFPORTS data and nowcast numerical model results are made available to users through the World Wide Web (WWW). A brief overview of SFPORTS is presented, from the data flow originated at instrument sensors to final results delivered to end users on the WWW. A user-friendly interface for SFPORTS has been designed and implemented. Appropriate field data analysis, nowcast procedures, design and generation of graphics for WWW display of field data and nowcast results are presented and discussed. Furthermore, SFPORTS is designed to support hazardous materials spill prevention and response, and to serve as resources to scientists studying the health of San Francisco Bay ecosystem. The success (or failure) of the SFPORTS to serve the intended user community is determined by the effectiveness of the user interface.

Evaluating the quality of life of people with profound and multiple disabilities: Use of the San Martín Scale at the Obra San Martín Foundation

Directory of Open Access Journals (Sweden)

Irene Hierro Zorrilla

2015-06-01

Full Text Available The San Martín Scale is an instrument used to measure the quality of life of people with significant disabilities with adequate levels reliability and validity. In 2012, the San Martín Scale was administered to 85 adults with intellectual disabilities who were provided supports at Obra San Martin Foundation (Santander. In this article, we describe the results obtained at the mesosystem level, an example at the microsystem level, and future areas of work identified from the results.

AMS San Diego Testbed - Calibration Data

Data.gov (United States)

Department of Transportation — The data in this repository were collected from the San Diego, California testbed, namely, I-15 from the interchange with SR-78 in the north to the interchange with...

Chemical profiles and pharmacological activities of Chang-Kang-Fang, a multi-herb Chinese medicinal formula, for treating irritable bowel syndrome.

Science.gov (United States)

Mao, Qian; Shi, Lei; Wang, Zhi-Gang; Luo, Yu-Hui; Wang, Yin-Yu; Li, Xue; Lu, Min; Ju, Jian-Min; Xu, Jin-Di; Kong, Ming; Zhou, Shan-Shan; Shen, Min-Qin; Li, Song-Lin

2017-04-06

Chang-Kang-Fang formula (CKF), a multi-herb traditional Chinese medicinal formula, has been clinically used for treatment of irritable bowel syndrome (IBS). The mechanisms of CKF for treating IBS and the components that are responsible for the activities were still unknown. To investigate the chemical profiles and effects of CKF on IBS model. The chemical profiles of CKF were investigated by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q/TOF-MS/MS). On colon irritation induced rat neonates IBS model, the influence of CKF on neuropeptides, including substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP) and 5-hydroxytryptamine (5-HT), were measured by ELISA, and the effect on intestinal sensitivity was assessed based on the abdominal withdrawal reflex (AWR) scores. In addition, the activities of CKF against acetic acid-induced nociceptive responses and prostigmin methylsulfate triggered intestinal propulsion in mice were also evaluated. 80 components were identified or tentatively assigned from CKF, including 11 alkaloids, 20 flavanoids, 4 monoterpenoids, 9 iridoid glycoside, 9 phenylethanoid glycosides, 10 chromones, 7 organic acid, 3 coumarins, 2 triterpene and 5 other compounds. On IBS rat model, CKF was observed to reduce AWR scores and levels of SP, CGRP, VIP and 5-HT. Moreover, CKF reduced the acetic acid-induced writhing scores at all dosages and reduced the intestinal propulsion ration at dosage of 7.5 and 15.0g/kg/d. CKF could alleviate the symptoms of IBS by modulating the brain-gut axis through increasing the production of neuropeptides such as CGRP, VIP, 5-HT and SP, releasing pain and reversing disorders of intestinal propulsion. Berberine, paeoniflorin, acteoside, flavonoids and chromones may be responsible for the multi-bioactivities of CKF. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Hydrologic data from wells at or in the vicinity of the San Juan coal mine, San Juan County, New Mexico

Science.gov (United States)

Stewart, Anne M.; Thomas, Nicole

2015-01-01

In 2010, in cooperation with the Mining and Minerals Division (MMD) of the State of New Mexico Energy, Minerals and Natural Resources Department, the U.S. Geological Survey (USGS) initiated a 4-year assessment of hydrologic conditions at the San Juan coal mine (SJCM), located about 14 miles west-northwest of the city of Farmington, San Juan County, New Mexico. The mine produces coal for power generation at the adjacent San Juan Generating Station (SJGS) and stores coal-combustion byproducts from the SJGS in mined-out surface-mining pits. The purpose of the hydrologic assessment is to identify groundwater flow paths away from SJCM coal-combustion-byproduct storage sites that might allow metals that may be leached from coal-combustion byproducts to eventually reach wells or streams after regional dewatering ceases and groundwater recovers to predevelopment levels. The hydrologic assessment, undertaken between 2010 and 2013, included compilation of existing data. The purpose of this report is to present data that were acquired and compiled by the USGS for the SJCM hydrologic assessment.

San Telmo, backpackers y otras globalizaciones

Directory of Open Access Journals (Sweden)

Fernando Firmo

2015-12-01

Full Text Available Este artículo pretende contribuir al debate sobre otras formas de globalización  presentando una etnografía realizada en el barrio de San Telmo sobre mochileros que combinan en sus experiencias viaje y trabajo. Su objetivo es viajar al mismo tiempo que sacan provecho de esto para conseguir el capital necesario que les permita continuar en movimiento alrededor del globo. En este texto quiero hablar sobre estos auténticos actores de la globalización popular que ponen el foco en procesos y agentes alternativos no hegemónicos y que en este caso desarrollan su actividad en el contexto de la experiencia mochilera en San Telmo, siendo mi intención enriquecer las reflexiones sobre la globalización desde abajo.

Low strength of deep San Andreas fault gouge from SAFOD core.

Science.gov (United States)

Lockner, David A; Morrow, Carolyn; Moore, Diane; Hickman, Stephen

2011-04-07

The San Andreas fault accommodates 28-34 mm yr(-1) of right lateral motion of the Pacific crustal plate northwestward past the North American plate. In California, the fault is composed of two distinct locked segments that have produced great earthquakes in historical times, separated by a 150-km-long creeping zone. The San Andreas Fault Observatory at Depth (SAFOD) is a scientific borehole located northwest of Parkfield, California, near the southern end of the creeping zone. Core was recovered from across the actively deforming San Andreas fault at a vertical depth of 2.7 km (ref. 1). Here we report laboratory strength measurements of these fault core materials at in situ conditions, demonstrating that at this locality and this depth the San Andreas fault is profoundly weak (coefficient of friction, 0.15) owing to the presence of the smectite clay mineral saponite, which is one of the weakest phyllosilicates known. This Mg-rich clay is the low-temperature product of metasomatic reactions between the quartzofeldspathic wall rocks and serpentinite blocks in the fault. These findings provide strong evidence that deformation of the mechanically unusual creeping portions of the San Andreas fault system is controlled by the presence of weak minerals rather than by high fluid pressure or other proposed mechanisms. The combination of these measurements of fault core strength with borehole observations yields a self-consistent picture of the stress state of the San Andreas fault at the SAFOD site, in which the fault is intrinsically weak in an otherwise strong crust. ©2011 Macmillan Publishers Limited. All rights reserved

Small angle neutron scattering (SANS) under non-equilibrium conditions

International Nuclear Information System (INIS)

Oberthur, R.C.

1984-01-01

The use of small angle neutron scattering (SANS) for the study of systems under non-equilibrium conditions is illustrated by three types of experiments in the field of polymer research: - the relaxation of a system from an initial non-equilibrium state towards equilibrium, - the cyclic or repetitive installation of a series of non-equilibrium states in a system, - the steady non-equilibrium state maintained by a constant dissipation of energy within the system. Characteristic times obtained in these experiments with SANS are compared with the times obtained from quasi-elastic neutron and light scattering, which yield information about the equilibrium dynamics of the system. The limits of SANS applied to non-equilibrium systems for the measurement of relaxation times at different length scales are shown and compared to the limits of quasielastic neutron and light scattering

San Jacinto Tries Management by Objectives

Science.gov (United States)

Deegan, William

1974-01-01

San Jacinto, California, has adopted a measurable institutional objectives approach to management by objectives. Results reflect, not only improved cost effectiveness of community college education, but also more effective educational programs for students. (Author/WM)

Solar-energy-system performance evaluation. San Anselmo School, San Jose, California, April 1981-March 1982

Energy Technology Data Exchange (ETDEWEB)

Pakkala, P.A.

1982-01-01

The San Anselmo School is a one-story brick elementary school building in San Jose, California. The active solar energy system is designed to supply 70% of the space heating and 72% of the cooling load. It is equipped with 3740 square feet of evacuated tube collectors, a 2175-gallon tank for heat storage, a solar-supplied absorption chiller, and four auxiliary gas-fired absorption chillers/heaters. The measured solar fraction of 19% is far below the expected values and is attributed to severe system control and HVAC problems. Other performance data given for the year include the solar savings ratio, conventional fuel savings, system performance factor, and solar system coefficient of performance. Also tabulated are monthly performance data for the overall solar energy system, collector subsystem, space heating and cooling subsystems. Typical hourly operation data for a day are tabulated, including hourly isolation, collector array temperatures (inlet and outlet), and storage fluid temperatures. The solar energy use and percentage of losses are also graphed. (LEW)

Solar-energy system performance evaluation. San Anselmo School, San Jose, California, July 1980-March 1981

Energy Technology Data Exchange (ETDEWEB)

Pakkala, P.A.

1981-01-01

The San Anselmo School is a one-story, brick elementary school building located in San Jose, California. The active solar energy system is designed to supply 70% of the heating load and 72% of the cooling load. It is equipped with 3.740 square feet of evacuated tube collectors, 2175-gallon tank for storage, four auxiliary gas-fired absorption chiller/heaters, and a solar-supplied absorption chiller. The measured heating and cooling solar fractions were 9% and 19%, respectively, for an overall solar fraction of 16%, the lowered performance being attributed to severe system control problems. Performance data include the solar savings ratio, conventional fuel savings, system performance factor, and solar system coefficient of performance. Performance data are presented for the overall system and for each subsystem. System operation and solar energy utilization data are included. Also included are a description of the system, performance evaluation techniques, sensor technology, and typical performance data for a month. Weather data are also tabulated. (LEW)

Como güelfos y gibelinos: los colegios de San Bernardo y San Antonio Abad en el Cuzco durante el siglo XVII

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Guibovich Pérez, Pedro M

2006-04-01

Full Text Available This article deals with the conflicts that involved the San Bernardo and San Antonio schools all along the seventeenth century. The author proposes a new approach to explain the social history of colonial Cuzco. He mantains that the root of the confrontation has to do with the privileges that enjoy the jesuits in the provision of academical degrees, a basic requirement to obtain appointments in the civil and eclesiastical administration. To understand this social dinamic, he reconstructs the institutional history of both schools, and reveals the interests that defend the main actors of this secular conflict.

Los conflictos que enfrentaron a los colegios de San Bernardo y San Antonio Abad a lo largo del siglo XVII es el tema central de estudio de este ensayo. El autor propone una nueva lectura a este episodio de la historia social del Cuzco colonial. Sostiene que en la raíz de los enfrentamientos estuvo el privilegio que gozaban los jesuitas para la concesión de grados académicos, requisitos fundamentales para obtener cargos en la administración civil y eclesiástica. Para entender la dinámica social, el autor reconstruye la historia institucional de los colegios y los intereses en juego de los principales protagonistas del secular conflicto.

"A different kind of beauty": scientific and architectural style in I.M. Pei's Mesa Laboratory and Louis Kahn's Salk Institute.

Science.gov (United States)

Leslie, Stuart W

2008-01-01

I.M. Pei's Mesa Laboratory for the National Center for Atmospheric Research in Boulder, Colorado, and Louis Kahn's Salk Institute in La Jolla, California, are rare examples of laboratories as celebrated for their architecture as for their scientific contributions. Completed in the mid-1960s, these signature buildings still express the scientific style of their founding directors, Walter Roberts and Jonas Salk. yet in commissioning their laboratories, Roberts and Salk had to work with architects as strong-willed as themselves. A close reading of the two laboratories reveals the ongoing negotiations and tensions in collaborations between visionary scientist and visionary architect. Moreover, Roberts and Salk also had to become architects of atmospheric and biomedical sciences. For laboratory architecture, however flexible in theory, necessarily stabilizes scientific practice, since a philosophy of research is embedded in the very structure of the building and persists far longer than the initial vision and mission that gave it life. Roberts and Salk's experiences suggest that even the most carefully designed laboratories must successfully adapt to new disciplinary configurations, funding opportunities, and research priorities, or risk becoming mere architectural icons.

April 1906 San Francisco, USA Images

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The 1906 San Francisco earthquake was the largest event (magnitude 8.3) to occur in the conterminous United States in the 20th Century. Recent estimates indicate...

SANS from interpenetrating polymer networks

International Nuclear Information System (INIS)

Markotsis, M.G.; Burford, R.P.; Knott, R.B.; Australian Nuclear Science and Technology Organisation, Menai, NSW; Hanley, T.L.; CRC for Polymers,; Australian Nuclear Science and Technology Organisation, Menai, NSW; Papamanuel, N.

2003-01-01

Full text: Interpenetrating polymer networks (IPNs) have been formed by combining two polymeric systems in order to gain enhanced material properties. IPNs are a combination of two or more polymers in network form with one network polymerised and/or crosslinked in the immediate presence of the other(s).1 IPNs allow better blending of two or more crosslinked networks. In this study two sets of IPNs were produced and their microstructure studied using a variety of techniques including small angle neutron scattering (SANS). The first system combined a glassy polymer (polystyrene) with an elastomeric polymer (SBS) with the glassy polymer predominating, to give a high impact plastic. The second set of IPNs contained epichlorohydrin (CO) and nitrile rubber (NBR), and was formed in order to produce novel materials with enhanced chemical and gas barrier properties. In both cases if the phase mixing is optimised the probability of controlled morphologies and synergistic behaviour is increased. The PS/SBS IPNs were prepared using sequential polymerisation. The primary SBS network was thermally crosslinked, then the polystyrene network was polymerised and crosslinked using gamma irradiation to avoid possible thermal degradation of the butadiene segment of the SBS. Tough transparent systems were produced with no apparent thermal degradation of the polybutadiene segments. The epichlorohydrin/nitrile rubber IPNs were formed by simultaneous thermal crosslinking reactions. The epichlorohydrin network was formed using lead based crosslinker, while the nitrile rubber was crosslinked by peroxide methods. The use of two different crosslinking systems was employed in order to achieve independent crosslinking thus resulting in an IPN with minimal grafting between the component networks. SANS, Transmission electron microscopy (TEM), and atomic force microscopy (AFM) were used to examine the size and shape of the phase domains and investigate any variation with crosslinking level and

The Basic Design Report of the 40M SANS Instrument

Energy Technology Data Exchange (ETDEWEB)

Han, Young Soo; Lee, Chang Hee; Hwang, Dong Gil; Kim, Hak Rho [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Tae Hwan; Choi, Sung Min [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

2006-04-15

The HANARO cold neutron research facility project was launched on July 1, 2003. A state of the art SANS instrument was selected as a top-priority instrument by an instrument selection committee, which consisted of domestic users and HANARO personnel. An instrument development team and an international and domestic instrument advisory team were formulated. The guide and the instrument simulation were performed using Vitess software and the optimum basic design was completed based on the simulation results and the international advisory team reviews. The optimum design of the guide for the 40M SANS instrument was completed and the optimum basic design of the 40M the SANS instrument was also completed based on the Vitess simulation results. The Q range of the instrument will cover from 0.0008 to 1.0 A-1 and the maximum flux at a sample position can reach about 5.5x10 7 n/cm2sec. The simulation results and the basic design product will be used for the detailed design and the construction of the SANS instrument. The simulation results could be applied to the development of the other instrument.

Radon emanation on San Andreas Fault

International Nuclear Information System (INIS)

King, C.-Y.

1978-01-01

It is stated that subsurface radon emanation monitored in shallow dry holes along an active segment of the San Andreas fault in central California shows spatially coherent large temporal variations that seem to be correlated with local seismicity. (author)

Crustal structure of the coastal and marine San Francisco Bay region, California

Science.gov (United States)

Parsons, Tom

2002-01-01

As of the time of this writing, the San Francisco Bay region is home to about 6.8 million people, ranking fifth among population centers in the United States. Most of these people live on the coastal lands along San Francisco Bay, the Sacramento River delta, and the Pacific coast. The region straddles the tectonic boundary between the Pacific and North American Plates and is crossed by several strands of the San Andreas Fault system. These faults, which are stressed by about 4 cm of relative plate motion each year, pose an obvious seismic hazard.

Poly-Cross-Linked PEI Through Aromatically Conjugated Imine Linkages as a New Class of pH-Responsive Nucleic Acids Packing Cationic Polymers

Science.gov (United States)

Chen, Shun; Jin, Tuo

2016-01-01

Cationic polyimines polymerized through aromatically conjugated bis-imine linkages and intra-molecular cross-linking were found to be a new class of effective transfection materials for their flexibility in structural optimization, responsiveness to intracellular environment, the ability to facilitate endosome escape and cytosol release of the nucleic acids, as well as self-metabolism. When three phthalaldehydes of different substitution positions were used to polymerize highly branched low-molecular weight polyethylenimine (PEI 1.8K), the product through ortho-phthalimines (named PPOP) showed significantly higher transfection activity than its two tere- and iso-analogs (named PPTP and PPIP). Physicochemical characterization confirmed the similarity of three polyimines in pH-responded degradability, buffer capacity, as well as the size and Zeta potential of the polyplexes formed from the polymers. A mechanistic speculation may be that the ortho-positioned bis-imine linkage of PPOP may only lead to the straight trans-configuration due to steric hindrance, resulting in larger loops of intra-polymer cross-linking and more flexible backbone. PMID:26869931

DNA array analysis of gene expression changes by Choto-san in the ischemic rat brain

OpenAIRE

Tohda, Michihisa; Matsumoto, Kinzo; Hayashi, Hisae; Murakami, Yukihisa; Watanabe, Hiroshi

2004-01-01

The effects of Choto-san on gene expression in the dementia model rat brain were studied using a DNA microarray system. Choto-san inhibited the expression of 181 genes that has been enhanced by permanent occlusion of the bilateral common carotid arteries (2VO). Choto-san also reversed the expression inhibition of 32 genes induced by 2VO. These results may suggest that Choto-san, which has been therapeutically used as an antidementive drug, shows therapeutic effects through gene expression cha...

Public Involvement and Response Plan (Community Relations Plan), Presidio of San Francisco, San Francisco, California

Science.gov (United States)

1992-03-01

passenger ship destination, and tourist attraction. San Francisco’s location and cultural and recreational opportunities make it a prime tourism center...equestrians, she said. C-52 m% smm : - TUESDAY, JUNE 19,1990 * . COPYKIGHT 1*90/THE TIMES MlRkOX COMPANY /CC/1 JO PAGES P. A-l, 22, 23 Complex

Comparison of SANS instruments at reactors and pulsed sources

International Nuclear Information System (INIS)

Thiyagarajan, P.; Epperson, J.E.; Crawford, R.K.; Carpenter, J.M.; Hjelm, R.P. Jr.

1992-01-01

Small angle neutron scattering is a general purpose technique to study long range fluctuations and hence has been applied in almost every field of science for material characterization. SANS instruments can be built at steady state reactors and at the pulsed neutron sources where time-of-flight (TOF) techniques are used. The steady state instruments usually give data over small q ranges and in order to cover a large q range these instruments have to be reconfigured several times and SANS measurements have to be made. These instruments have provided better resolution and higher data rates within their restricted q ranges until now, but the TOF instruments are now developing to comparable performance. The TOF-SANS instruments, by using a wide band of wavelengths, can cover a wide dynamic q range in a single measurement. This is a big advantage for studying systems that are changing and those which cannot be exactly reproduced. This paper compares the design concepts and performances of these two types of instruments

Volcano hazards in the San Salvador region, El Salvador

Science.gov (United States)

Major, J.J.; Schilling, S.P.; Sofield, D.J.; Escobar, C.D.; Pullinger, C.R.

2001-01-01

San Salvador volcano is one of many volcanoes along the volcanic arc in El Salvador (figure 1). This volcano, having a volume of about 110 cubic kilometers, towers above San Salvador, the country’s capital and largest city. The city has a population of approximately 2 million, and a population density of about 2100 people per square kilometer. The city of San Salvador and other communities have gradually encroached onto the lower flanks of the volcano, increasing the risk that even small events may have serious societal consequences. San Salvador volcano has not erupted for more than 80 years, but it has a long history of repeated, and sometimes violent, eruptions. The volcano is composed of remnants of multiple eruptive centers, and these remnants are commonly referred to by several names. The central part of the volcano, which contains a large circular crater, is known as El Boquerón, and it rises to an altitude of about 1890 meters. El Picacho, the prominent peak of highest elevation (1960 meters altitude) to the northeast of the crater, and El Jabali, the peak to the northwest of the crater, represent remnants of an older, larger edifice. The volcano has erupted several times during the past 70,000 years from vents central to the volcano as well as from smaller vents and fissures on its flanks [1] (numerals in brackets refer to end notes in the report). In addition, several small cinder cones and explosion craters are located within 10 kilometers of the volcano. Since about 1200 A.D., eruptions have occurred almost exclusively along, or a few kilometers beyond, the northwest flank of the volcano, and have consisted primarily of small explosions and emplacement of lava flows. However, San Salvador volcano has erupted violently and explosively in the past, even as recently as 800 years ago. When such eruptions occur again, substantial population and infrastructure will be at risk. Volcanic eruptions are not the only events that present a risk to local

Implementation of an Online Climate Science Course at San Antonio College

Science.gov (United States)

Reyes, R.; Strybos, J.

2016-12-01

San Antonio College (SAC) plans to incorporate an online climate science class into the curriculum with a focus on local weather conditions and data. SAC is part of a network of five community colleges based around San Antonio, Texas, has over 20,000 students enrolled, and its student population reflects the diversity in ethnicity, age and gender of the San Antonio community. The college understands the importance of educating San Antonio residents on climate science and its complexities. San Antonio residents are familiar with weather changes and extreme conditions. The region has experienced an extreme drought, including water rationing in the city. Then, this year's El Niño intensified expected annual rainfalls and flash floods. The proposed climate science course will uniquely prepare students to understand weather data and the evidence of climate change impacting San Antonio at a local level. This paper will discuss the importance and challenges of introducing the new climate science course into the curriculum, and the desired class format that will increase the course's success. Two of the most significant challenges are informing students about the value of this class and identifying the best teaching format. Additionally, measuring and monitoring enrollment will be essential to determine the course performance and success. At the same time, Alamo Colleges is modifying the process of teaching online classes and is officially working to establish an online college. Around 23% of students enrolled in SAC offered courses are currently enrolled in online courses only, representing an opportunity to incorporate the climate science class as an online course. Since the proposed course will be using electronic textbooks and online applications to access hyperlocal weather data, the class is uniquely suited for online students.

SANS study of three-layer micellar particles

CERN Document Server

Plestil, J; Kuklin, A I; Cubitt, R

2002-01-01

Three-layer nanoparticles were prepared by polymerization of methyl methacrylate (MMA) in aqueous micellar solutions of poly(methyl methacrylate)-block-poly(methacrylic acid) (PMMA-b-PMA) and polystyrene-block-poly(methacrylic acid) (PS-b-PMA). The resulting polymer forms a layer on the core surface of the original micelles. SANS curves were fitted using an ellipsoidal (PMMA/PMMA/PMA) or spherical (PS/PMMA/PMA) model for the particle core. The particle size (for the presented series of the PMMA/PMMA/PMA particles, the core semiaxes ranged from 87 to 187 A and the axis ratio was about 6) can be finely tuned by variation of monomer concentration. Time-resolved SANS experiments were carried out to describe the growth of the PS/PMMA/PMA particles during polymerization. (orig.)

Identifying clinically meaningful symptom response cut-off values on the SANS in predominant negative symptoms.

Science.gov (United States)

Levine, Stephen Z; Leucht, Stefan

2013-04-01

The treatment and measurement of negative symptoms are currently at issue in schizophrenia, but the clinical meaning of symptom severity and change is unclear. To offer a clinically meaningful interpretation of severity and change scores on the Scale for the Assessment of Negative Symptoms (SANS). Patients were intention-to-treat participants (n=383) in two double-blind randomized placebo-controlled clinical trials that compared amisulpride with placebo for the treatment of predominant negative symptoms. Equipercentile linking was used to examine extrapolation from (a) CGI-S to SANS severity ratings, and (b) CGI-I to SANS percentage change (n=383). Linking was conducted at baseline, 8-14 days, 28-30 days, and 56-60 days of the trials. Across visits, CGI-S ratings of 'not ill' linked to SANS scores of 0-13, and ranged to 'extreme' ratings that linked to SANS scores of 102-105. The relationship between the CGI-S and the SANS severity scores assumed a linear trend (1=0-13, 2=15-56, 3=37-61, 4=49-66, 5=63-75, 6=79-89, 7=102-105). Similarly the relationship between CGI-I ratings and SANS percentage change followed a linear trend. For instance, CGI-I ratings of 'very much improved' were linked to SANS percent changes of -90 to -67, 'much improved' to -50 to -42, and 'minimally improved' to -21 to -13. The current results uniquely contribute to the debate surrounding negative symptoms by providing clinical meaning to SANS severity and change scores and so offer direction regarding clinically meaningful response cut-off scores to guide treatment targets of predominant negative symptoms. Copyright © 2013 Elsevier B.V. All rights reserved.

Characterization of the Drosophila ortholog of the human Usher Syndrome type 1G protein sans.

Directory of Open Access Journals (Sweden)

Fabio Demontis

Full Text Available BACKGROUND: The Usher syndrome (USH is the most frequent deaf-blindness hereditary disease in humans. Deafness is attributed to the disorganization of stereocilia in the inner ear. USH1, the most severe subtype, is associated with mutations in genes encoding myosin VIIa, harmonin, cadherin 23, protocadherin 15, and sans. Myosin VIIa, harmonin, cadherin 23, and protocadherin 15 physically interact in vitro and localize to stereocilia tips in vivo, indicating that they form functional complexes. Sans, in contrast, localizes to vesicle-like structures beneath the apical membrane of stereocilia-displaying hair cells. How mutations in sans result in deafness and blindness is not well understood. Orthologs of myosin VIIa and protocadherin 15 have been identified in Drosophila melanogaster and their genetic analysis has identified essential roles in auditory perception and microvilli morphogenesis, respectively. PRINCIPAL FINDINGS: Here, we have identified and characterized the Drosophila ortholog of human sans. Drosophila Sans is expressed in tubular organs of the embryo, in lens-secreting cone cells of the adult eye, and in microvilli-displaying follicle cells during oogenesis. Sans mutants are viable, fertile, and mutant follicle cells appear to form microvilli, indicating that Sans is dispensable for fly development and microvilli morphogenesis in the follicle epithelium. In follicle cells, Sans protein localizes, similar to its vertebrate ortholog, to intracellular punctate structures, which we have identified as early endosomes associated with the syntaxin Avalanche. CONCLUSIONS: Our work is consistent with an evolutionary conserved function of Sans in vesicle trafficking. Furthermore it provides a significant basis for further understanding of the role of this Usher syndrome ortholog in development and disease.

The aquatic annelid fauna of the San Marcos River headsprings, Hays County, Texas

Directory of Open Access Journals (Sweden)

McLean L.D. Worsham

2016-09-01

Full Text Available The San Marcos River in Central Texas has been well studied and has been demonstrated to be remarkably specious. Prior to the present study, research on free-living invertebrates in the San Marcos River only dealt with hard bodied taxa with the exception of the report of one gastrotrich, and one subterranean platyhelminth that only incidentally occurs in the head spring outflows. The remainder of the soft-bodied metazoan fauna that inhabit the San Marcos River had never been studied. Our study surveyed the annelid fauna and some other soft-bodied invertebrates of the San Marcos River headsprings. At least four species of Hirudinida, two species of Aphanoneura, one species of Branchiobdellida, and 11 (possibly 13 species of oligochaetous clitellates were collected. Other vermiform taxa collected included at least three species of Turbellaria and one species of Nemertea. We provide the results of the first survey of the aquatic annelid fauna of the San Marcos Springs, along with a dichotomous key to these annelids that includes photos of some representative specimens, and line drawings to elucidate potentially confusing diagnostic structures.

The aquatic annelid fauna of the San Marcos River headsprings, Hays County, Texas

Science.gov (United States)

Worsham, McLean L. D.; Gibson, Randy; Huffman, David G.

2016-01-01

Abstract The San Marcos River in Central Texas has been well studied and has been demonstrated to be remarkably specious. Prior to the present study, research on free-living invertebrates in the San Marcos River only dealt with hard bodied taxa with the exception of the report of one gastrotrich, and one subterranean platyhelminth that only incidentally occurs in the head spring outflows. The remainder of the soft-bodied metazoan fauna that inhabit the San Marcos River had never been studied. Our study surveyed the annelid fauna and some other soft-bodied invertebrates of the San Marcos River headsprings. At least four species of Hirudinida, two species of Aphanoneura, one species of Branchiobdellida, and 11 (possibly 13) species of oligochaetous clitellates were collected. Other vermiform taxa collected included at least three species of Turbellaria and one species of Nemertea. We provide the results of the first survey of the aquatic annelid fauna of the San Marcos Springs, along with a dichotomous key to these annelids that includes photos of some representative specimens, and line drawings to elucidate potentially confusing diagnostic structures. PMID:27853397

SAFOD Penetrates the San Andreas Fault

Directory of Open Access Journals (Sweden)

Mark D. Zoback

2006-03-01

Full Text Available SAFOD, the San Andreas Fault Observatory at Depth (Fig. 1, completed an important milestone in July 2005 by drilling through the San Andreas Fault at seismogenic depth. SAFOD is one of three major components of EarthScope, a U.S. National Science Foundation (NSF initiative being conducted in collaboration with the U.S. Geological Survey (USGS. The International Continental Scientific DrillingProgram (ICDP provides engineering and technical support for the project as well as online access to project data and information (http://www.icdp-online.de/sites/sanandreas/news/news1.html. In 2002, the ICDP, the NSF, and the USGS provided funding for a pilot hole project at the SAFOD site. Twenty scientifi c papers summarizing the results of the pilot hole project as well as pre-SAFOD site characterization studies were published in Geophysical Research Letters (Vol.31, Nos. 12 and 15, 2004.

High intensity multi beam design of SANS instrument for Dhruva reactor

Energy Technology Data Exchange (ETDEWEB)

Abbas, Sohrab, E-mail: abbas@barc.gov.in; Aswal, V. K. [Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Désert, S. [Laboratoire Leon Brillouin, CEA, Saclay, 91191 (France)

2016-05-23

A new and versatile design of Small Angle Neutron Scattering (SANS) instrument based on utilization of multi-beam is presented. The multi-pinholes and multi-slits as SANS collimator for medium flux Dhruva rearctor have been proposed and their designs have been validated using McStas simulations. Various instrument configurations to achieve different minimum wave vector transfers in scattering experiments are envisioned. These options enable smooth access to minimum wave vector transfers as low as ~ 6×10{sup −4} Å{sup −1} with a significant improvement in neutron intensity, allowing faster measurements. Such angularly well defined and intense neutron beam will allow faster SANS studies of agglomerates larger than few tens of nm.

San Francisco-Pacifica Coast Landslide Susceptibility 2011

Data.gov (United States)

California Natural Resource Agency — The San Francisco-Pacifica Coast grid map was extracted from the California Geological Survey Map Sheet 58 that covers the entire state of California and originally...

75 FR 59285 - Endangered and Threatened Wildlife and Plants; Permit, San Luis Obispo County, CA

Science.gov (United States)

2010-09-27

...] Endangered and Threatened Wildlife and Plants; Permit, San Luis Obispo County, CA AGENCY: U.S. Fish and... project in the community of Los Osos, San Luis Obispo County, California. We invite comments from the... community of Los Osos, San Luis Obispo County, California. The parcel is legally described as Assessor...

San Francisco Bay Area Baseline Trash Loading Summary Results, San Francisco Bay Area CA, 2012, US EPA Region 9

Data.gov (United States)

U.S. Environmental Protection Agency — The San Francisco Bay Area stormwater permit sets trash control guidelines for discharges through the storm drain system. The permit covers Alameda, Contra Costa,...

Zemětřesná aktivita na zlomu San Andreas

OpenAIRE

Voroňáková, Jana

2011-01-01

SUMMARY: This work deals with the San Andreas fault as a tectonically active area. It includes basic information about the fracture, its origins and history. The work shows, as scientists are now trying to combat the risk of impending earthquakes. Project of San Andreas Fault Observatory at Depth and individual predictions of the next earthquake rupture are described.

Chlorinated hydrocarbon pesticides and polychlorinated biphenyls in sediment cores from San Francisco Bay

Science.gov (United States)

Venkatesan, M.I.; De Leon, R. P.; VanGeen, A.; Luoma, S.N.

1999-01-01

Sediment cores of known chronology from Richardson and San Pablo Bays in San Francisco Bay, CA, were analyzed for a suite of chlorinated hydrocarbon pesticides and polychlorinated biphenyls to reconstruct a historic record of inputs. Total DDTs (DDT = 2,4'- and 4,4'-dichlorodiphenyltrichloroethane and the metabolites, 2,4'- and 4,4'-DDE, -DDD) range in concentration from 4-21 ng/g and constitute a major fraction (> 84%) of the total pesticides in the top 70 cm of Richardson Bay sediment. A subsurface maximum corresponds to a peak deposition date of 1969-1974. The first measurable DDT levels are found in sediment deposited in the late 1930's. The higher DDT inventory in the San Pablo relative to the Richardson Bay core probably reflects the greater proximity of San Pablo Bay to agricultural activities in the watershed of the Sacramento and San Joaquin rivers. Total polychlorinated biphenyls (PCBs) occur at comparable levels in the two Bays (inventories in San Pablo Bay are about a factor of four higher in the last four decades than in Richardson Bay, suggesting a distribution of inputs not as strongly weighed towards the upper reaches of the estuary as DDTs. The shallower subsurface maximum in PCBs compared to DDT in the San Pablo Bay core is consistent with the imposition of drastic source control measures four these constituents in 1970 and 1977 respectively. The observed decline in DDT and PCB levels towards the surface of both cores is consistent with a dramatic drop in the input of these pollutants once the effect of sediment resuspension and mixing is taken into account.

Characterization of aerosols in the Metropolitan Area of San Jose

International Nuclear Information System (INIS)

Mejias Perez, J.A.

1997-07-01

The objective of the present study, was to elaborate a profile of the contamination by private matter and to characterize the aerosols collected in the Metropolitan Area of San Jose (Costa Rica). For that, a campaign of sampling was carried out in three points of the city of San Jose, differentiated by there degree of activity: Center of San Jose (Central Station of Firemen), San Isidro of Coronado -Canton of Vasquez of Coronado- (Municipality) and Escazu (Municipality). Such campaign was carried out from April 4 to July 4, 1996 (transition summer-winter), and in two periods of time of 8 hours: 8 a.m. to 4 p.m. and of 8 p.m. to 4 a.m. The aerosols were collected utilizing Gent Pm-10 samplers, in filters of polycarbonate of 0,4 μm and 8 μm in cascade, with a flow average of 15 L/min., and it determined the composition average of the present aerosols. The concentration of the majority of the anions were obtained by means of ionic chromatography of high resolution, and the main cations by spectrophotometry of atomic absorption with electro thermic atomization. The space-temporary variations of the concentrations were evaluated and their correlation with the meteorologic variable. (S. Grainger) [es

New record of Boa constrictor occidentalis Philippi, 1873 (Serpentes: Boidae) in San Juan province, Argentina

OpenAIRE

Martínez, Tomás; Rodriguez Muñoz, Melina; Galdeano, Ana; Acosta, Juan

2015-01-01

We document the first record of Boa constrictor in Valle Fértil department, San Juan province, Argentina. The specimen was collected and deposited in the herpetological collection of the Department of Biology, Universidad Nacional San Juan. This record extends the known distribution for this species in San Juan province by 105 km.

Choto-san in the treatment of vascular dementia: a double-blind, placebo-controlled study.

Science.gov (United States)

Terasawa, K; Shimada, Y; Kita, T; Yamamoto, T; Tosa, H; Tanaka, N; Saito, Y; Kanaki, E; Goto, S; Mizushima, N; Fujioka, M; Takase, S; Seki, H; Kimura, I; Ogawa, T; Nakamura, S; Araki, G; Maruyama, I; Maruyama, Y; Takaori, S

1997-03-01

In an earlier placebo-controlled study, we demonstrated that a kampo (Japanese herbal) medicine called Choto-san (Diao-Teng-San in Chinese) was effective in treating vascular dementia. To evaluate its efficacy using more objective criteria, we carried out a multi-center, double-blind study of Choto-san extract (7.5 g/day) and a placebo, each given three times a day for 12 weeks to patients suffering from this condition. The study enrolled and analyzed 139 patients, 50 males and 89 females, with a mean age of 76.6 years. Choto-san was statistically superior to the placebo in global improvement rating, utility rating, global improvement rating of subjective symptoms, global improvement rating of psychiatric symptoms and global improvement rating of disturbance in daily living activities. Such items as spontaneity of conversation, lack of facial expression, decline in simple mathematical ability, global intellectual ability, nocturnal delirium, sleep disturbance, hallucination or delusion, and putting on and taking off clothes were significantly improved at one or more evaluation points in those taking Choto-san compared to those taking the placebo. Furthermore, the change in revised version of Hasegawa's dementia scale from the beginning point in Choto-san group was tended to be higher than that in placebo group with no statistical significance. These results suggest that Choto-san is effective in the treatment of vascular dementia. Copyright © 1997 Gustav Fischer Verlag. Published by Elsevier GmbH.. All rights reserved.

Phosphorylation of the Usher syndrome 1G protein SANS controls Magi2-mediated endocytosis.

Science.gov (United States)

Bauß, Katharina; Knapp, Barbara; Jores, Pia; Roepman, Ronald; Kremer, Hannie; Wijk, Erwin V; Märker, Tina; Wolfrum, Uwe

2014-08-01

The human Usher syndrome (USH) is a complex ciliopathy with at least 12 chromosomal loci assigned to three clinical subtypes, USH1-3. The heterogeneous USH proteins are organized into protein networks. Here, we identified Magi2 (membrane-associated guanylate kinase inverted-2) as a new component of the USH protein interactome, binding to the multifunctional scaffold protein SANS (USH1G). We showed that the SANS-Magi2 complex assembly is regulated by the phosphorylation of an internal PDZ-binding motif in the sterile alpha motif domain of SANS by the protein kinase CK2. We affirmed Magi2's role in receptor-mediated, clathrin-dependent endocytosis and showed that phosphorylated SANS tightly regulates Magi2-mediated endocytosis. Specific depletions by RNAi revealed that SANS and Magi2-mediated endocytosis regulates aspects of ciliogenesis. Furthermore, we demonstrated the localization of the SANS-Magi2 complex in the periciliary membrane complex facing the ciliary pocket of retinal photoreceptor cells in situ. Our data suggest that endocytotic processes may not only contribute to photoreceptor cell homeostasis but also counterbalance the periciliary membrane delivery accompanying the exocytosis processes for the cargo vesicle delivery. In USH1G patients, mutations in SANS eliminate Magi2 binding and thereby deregulate endocytosis, lead to defective ciliary transport modules and ultimately disrupt photoreceptor cell function inducing retinal degeneration. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

76 FR 45212 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2011-07-28

... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... proposing to approve San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) Rule 3170... the environment. San Joaquin Valley Unified Air Pollution Control District SJVUAPCD is an extreme...

First experiences with large SAN storage and Linux

International Nuclear Information System (INIS)

Wezel, Jos van; Marten, Holger; Verstege, Bernhard; Jaeger, Axel

2004-01-01

The use of a storage area network (SAN) with Linux opens possibilities for scalable and affordable large data storage and poses a new challenge for cluster computing. The GridKa center uses a commercial parallel file system to create a highly available high-speed data storage using a combination of Fibre Channel (SAN) and Ethernet (LAN) to optimize between data throughput and costs. This article describes the design, implementation and optimizations of the GridKa storage solution which will offer over 400 TB online storage for 600 nodes. Presented are some throughput measurements of one of the largest Linux-based parallel storage systems in the world

Medicinal use of plants by the peasant community of San Jacinto, northern Colombia Medicinal use of plants by the peasant community of San Jacinto, northern Colombia

Directory of Open Access Journals (Sweden)

Bonzani Renée M.

1999-11-01

Full Text Available I studied the medicinal use of plants by the peasant community of the town of San Jacinto, located in the savanna of Bolívar, northern Colombia. Fifty-five families, 138 genera, and 118 species were scientifically identified from 249 specimens collected of the modern-day vegetation of San Jacinto. From these, 198 uses were recorded for 190 (76% of the specimens. The 54 uses recorded for human medicine (27% and the five uses recorded for animal medicine (2% are discussed. Vernacular names, parts used, method of preparation, and medicinal uses are listed.Se presenta un estudio etnobotánico de la comunidad campesina del pueblo de San Jacinto, localizado en las sabanas de Bolívar, norte de Colombia. Se identificaron científicamente 55 familias, 138 géneros, y 118 especies con base en 249 especímenes recolectados de la vegetación de San Jacinto. De esos, se establecieron 198 usos para 190 (76% especímenes. Se presentan 54 usos para medicina humana (27% y cinco usos para medicina animal (2%. Se listan nombres vernáculos, partes usadas, método de preparación, y usos medicinales.

Irregular recurrence of large earthquakes along the san andreas fault: evidence from trees.

Science.gov (United States)

Jacoby, G C; Sheppard, P R; Sieh, K E

1988-07-08

Old trees growing along the San Andreas fault near Wrightwood, California, record in their annual ring-width patterns the effects of a major earthquake in the fall or winter of 1812 to 1813. Paleoseismic data and historical information indicate that this event was the "San Juan Capistrano" earthquake of 8 December 1812, with a magnitude of 7.5. The discovery that at least 12 kilometers of the Mojave segment of the San Andreas fault ruptured in 1812, only 44 years before the great January 1857 rupture, demonstrates that intervals between large earthquakes on this part of the fault are highly variable. This variability increases the uncertainty of forecasting destructive earthquakes on the basis of past behavior and accentuates the need for a more fundamental knowledge of San Andreas fault dynamics.

Postseismic relaxation along the San Andreas fault at Parkfield from continuous seismological observations.

Science.gov (United States)

Brenguier, F; Campillo, M; Hadziioannou, C; Shapiro, N M; Nadeau, R M; Larose, E

2008-09-12

Seismic velocity changes and nonvolcanic tremor activity in the Parkfield area in California reveal that large earthquakes induce long-term perturbations of crustal properties in the San Andreas fault zone. The 2003 San Simeon and 2004 Parkfield earthquakes both reduced seismic velocities that were measured from correlations of the ambient seismic noise and induced an increased nonvolcanic tremor activity along the San Andreas fault. After the Parkfield earthquake, velocity reduction and nonvolcanic tremor activity remained elevated for more than 3 years and decayed over time, similarly to afterslip derived from GPS (Global Positioning System) measurements. These observations suggest that the seismic velocity changes are related to co-seismic damage in the shallow layers and to deep co-seismic stress change and postseismic stress relaxation within the San Andreas fault zone.

San Francisco Bay Interferometric Bathymetry: Area B

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — High resolution sonar data were collected over ultra-shallow areas of the San Francisco Bay estuary system. Bathymetric and acoustic backscatter data were collected...

78 FR 48046 - Safety Zone; Kuoni Destination Management Fireworks; San Diego, CA

Science.gov (United States)

2013-08-07

...-AA00 Safety Zone; Kuoni Destination Management Fireworks; San Diego, CA AGENCY: Coast Guard, DHS... waters of the San Diego Bay in support of the Kuoni Destination Management Fireworks Display on August 6... Guard's ability to protect the public from the potential hazards associated with fireworks displays...

Cuisine Preference of Local Tourists in San Juan, Batangas, Philippines

OpenAIRE

RYENE SELLINE B. KALALO; ANGELICA LYNTTE A. CABLAO; MARICRISS P. CABATAY; CHARISSA P. MANTAL; RHONALYN T. MANALO; SEVILLA S. FELICEN

2014-01-01

This study aimed to determine the cuisine preference of the local tourist in San Juan, Batangas. More specifically, it aimed to describe the demographic profile of local tourist; to identify the preferred cuisine by different restaurants; to determine the significant difference when group according to demographic profile; and to determine the cuisine preference of local tourists in San Juan, Batangas. The research design used the descriptive method because it is the most appropria...

A SANS study of capillary condensation in porous media

International Nuclear Information System (INIS)

Lin, M.; Glinka, C.; Sinna, S.; Huang, J.; Abeles, B.; Johnson, J.; Drake, J.

1990-01-01

The authors use small angle neutron scattering (SANS) to study the microstructure of porous Vycor glass and the capillary condensation of fluids in the medium. Using a chord distribution model, they can predict the structure factor measured by SANS. Excellent agreement with the data is obtained. The fitted parameters characterize quantitatively the porous structure before and during the process of condensation, and are in good agreement with isotherm measurements. However, at the latest stages of the process, when all the pores are nearly filled, the model can no longer describe the system

77 FR 48532 - Notice of Intent To Repatriate Cultural Items: San Diego State University, San Diego, CA

Science.gov (United States)

2012-08-14

... Management Program, in consultation with the appropriate Indian tribe, has determined that the cultural items... itself to be culturally affiliated with the cultural items may contact San Diego State University Archaeology Collections Management Program. DATES: Representatives of any Indian tribe that believes it has a...

Caracterización de las principales pesquerías del golfo San Jorge Patagonia, Argentina Characterization of the main fisheries in San Jorge Gulf, Patagonia, Argentina

Directory of Open Access Journals (Sweden)

María Eva Góngora

2012-03-01

Full Text Available En el golfo San Jorge se desarrollan varias actividades económicas de relevancia, entre ellas dos pesquerías industriales: la pesquería de merluza común (Merluccius hubbsi Marini, 1933 y la pesquería de langostino patagónico (Pleoticus muelleri Bate, 1888, ambas se solapan espacial y temporalmente. En la pesquería de merluza del golfo San Jorge opera una flota fresquera de altura, compuesta por unas 20 embarcaciones, y una flota costera, compuesta por unas 30 embarcaciones. En esta pesquería se pesca alrededor del 10% de lo capturado en el stock sur de merluza. En la pesquería de langostino del golfo San Jorge opera una flota congeladora tangonera compuesta por 80 embarcaciones, responsable de más del 75% de los desembarques de langostino realizados en la República Argentina. Ambas pesquerías tienen como principal problema la captura incidental de merluza, en una de sus principales áreas de cría. En el presente trabajo se describe el manejo actual en las pesquerías del golfo San Jorge, el cual consiste principalmente en cierres espaciales y temporales para la pesca de langostino, y zonificaciones por estrato de flota para la merluza. En ninguna de las dos pesquerías descriptas se han tomado medidas que reduzcan eficazmente la captura incidental.In San Jorge Gulf, several important economic activities are developed, including two industrial fisheries: hake (Merluccius hubbsi Marini, 1933 and Argentine red shrimp (Pleoticus muelleri Bate, 1888. Both overlap spatially and temporally. The San Jorge Gulf hake fishery consists of a high-seas ice trawler fleet (n = 20 fishing vessels and a coastal fleet (n = 30 fishing vessels. These fisheries capture about 10% of the catch of the southern hake stock. The Argentine red shrimp fishery consists of a double-beam trawler fleet with 80 freezer vessels, responsible for more than 75% of shrimp landings in Argentina. The main problem of both fisheries is the bycatch of hake in one of its

Estudio constructivo y análisis de la Sacristía de la iglesia de San Miguel y San Sebastián

OpenAIRE

RUBIO MUÑOZ, RUBÉN

2017-01-01

La iglesia de San Miguel y San Sebastián, de Cardona y Pertusa, es un edificio erigido en el siglo XVIII, con anterioridad a la creación de la Academia de Bellas Artes, en que se produce la transición de la arquitectura y los oficios relacionados con la construcción. La Sacristía de la citada iglesia, de planta de cruz griega y con cúpula centra, es uno de los mejores ejemplos de la arquitectura del periodo y que, por desgracia, poco conocida. En el TFG se pretende realizar un exhaustivo l...

San Rafael mining and fabrication complex today

International Nuclear Information System (INIS)

Navarra, Pablo; Aldebert, Sergio R.

2005-01-01

In Mendoza province, 35 km West San Rafael city, is located a CNEA installation for uranium ore extraction and concentration: the San Rafael Mining and Fabrication Complex. By the middle of the nineties, as a consequence of the very low prices of uranium concentrate in the international market and of the high internal production costs, uranium extraction was stopped. To day, the international price of the concentrate had a very important increase and the Government has decided the completion of the Atucha II Nuclear Power Station construction. Moreover, studies have been started for new nuclear power plants. In such circumstances the reactivation of the Complex will make sure the uranium supply for our nuclear power stations, contributing to the improvement of the energy generation mix in our country. (author) [es

Interseismic strain accumulation and the earthquake potential on the southern San Andreas fault system.

Science.gov (United States)

Fialko, Yuri

2006-06-22

The San Andreas fault in California is a mature continental transform fault that accommodates a significant fraction of motion between the North American and Pacific plates. The two most recent great earthquakes on this fault ruptured its northern and central sections in 1906 and 1857, respectively. The southern section of the fault, however, has not produced a great earthquake in historic times (for at least 250 years). Assuming the average slip rate of a few centimetres per year, typical of the rest of the San Andreas fault, the minimum amount of slip deficit accrued on the southern section is of the order of 7-10 metres, comparable to the maximum co-seismic offset ever documented on the fault. Here I present high-resolution measurements of interseismic deformation across the southern San Andreas fault system using a well-populated catalogue of space-borne synthetic aperture radar data. The data reveal a nearly equal partitioning of deformation between the southern San Andreas and San Jacinto faults, with a pronounced asymmetry in strain accumulation with respect to the geologically mapped fault traces. The observed strain rates confirm that the southern section of the San Andreas fault may be approaching the end of the interseismic phase of the earthquake cycle.

Talc-bearing serpentinite and the creeping section of the San Andreas fault.

Science.gov (United States)

Moore, Diane E; Rymer, Michael J

2007-08-16

The section of the San Andreas fault located between Cholame Valley and San Juan Bautista in central California creeps at a rate as high as 28 mm yr(-1) (ref. 1), and it is also the segment that yields the best evidence for being a weak fault embedded in a strong crust. Serpentinized ultramafic rocks have been associated with creeping faults in central and northern California, and serpentinite is commonly invoked as the cause of the creep and the low strength of this section of the San Andreas fault. However, the frictional strengths of serpentine minerals are too high to satisfy the limitations on fault strength, and these minerals also have the potential for unstable slip under some conditions. Here we report the discovery of talc in cuttings of serpentinite collected from the probable active trace of the San Andreas fault that was intersected during drilling of the San Andreas Fault Observatory at Depth (SAFOD) main hole in 2005. We infer that the talc is forming as a result of the reaction of serpentine minerals with silica-saturated hydrothermal fluids that migrate up the fault zone, and the talc commonly occurs in sheared serpentinite. This discovery is significant, as the frictional strength of talc at elevated temperatures is sufficiently low to meet the constraints on the shear strength of the fault, and its inherently stable sliding behaviour is consistent with fault creep. Talc may therefore provide the connection between serpentinite and creep in the San Andreas fault, if shear at depth can become localized along a talc-rich principal-slip surface within serpentinite entrained in the fault zone.

SANS and TEM studies of carbide precipitation and creep damage in type 304 stainless steel

International Nuclear Information System (INIS)

Yoo, M.H.; Ogle, J.C.; Schneibel, J.H.; Swindeman, R.W.

1984-01-01

Small-angle neutron scattering (SANS) and transmission electron microscopy (TEM) studies were performed to characterize the carbide (M 23 C 6 ) precipitation and creep damage induced in type 304 stainless steel in the primary creep stage. The size distribution of matrix carbides evaluated from SANS analyses was consistent with TEM data, and the expected accelerated kinetics of precipitation under applied stress was confirmed. Additional SANS measurements after the postcreep solution annealing were made in order to differentiate cavities from the carbides. Potential advantages and difficulties associated with characterization of creep-induced cavitation by the SANS techniques are discussed

33 CFR 165.1120 - Security Zone; Naval Amphibious Base, San Diego, CA.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; Naval Amphibious Base, San Diego, CA. 165.1120 Section 165.1120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT... § 165.1120 Security Zone; Naval Amphibious Base, San Diego, CA. (a) Location. The following area is a...

Aggregate Settling Velocities in San Francisco Estuary Margins

Science.gov (United States)

Allen, R. M.; Stacey, M. T.; Variano, E. A.

2015-12-01

One way that humans impact aquatic ecosystems is by adding nutrients and contaminants, which can propagate up the food web and cause blooms and die-offs, respectively. Often, these chemicals are attached to fine sediments, and thus where sediments go, so do these anthropogenic influences. Vertical motion of sediments is important for sinking and burial, and also for indirect effects on horizontal transport. The dynamics of sinking sediment (often in aggregates) are complex, thus we need field data to test and validate existing models. San Francisco Bay is well studied and is often used as a test case for new measurement and model techniques (Barnard et al. 2013). Settling velocities for aggregates vary between 4*10-5 to 1.6*10-2 m/s along the estuary backbone (Manning and Schoellhamer 2013). Model results from South San Francisco Bay shoals suggest two populations of settling particles, one fast (ws of 9 to 5.8*10-4 m/s) and one slow (ws of Brand et al. 2015). While the open waters of San Francisco Bay and other estuaries are well studied and modeled, sediment and contaminants often originate from the margin regions, and the margins remain poorly characterized. We conducted a 24 hour field experiment in a channel slough of South San Francisco Bay, and measured settling velocity, turbulence and flow, and suspended sediment concentration. At this margin location, we found average settling velocities of 4-5*10-5 m/s, and saw settling velocities decrease with decreasing suspended sediment concentration. These results are consistent with, though at the low end of, those seen along the estuary center, and they suggest that the two population model that has been successful along the shoals may also apply in the margins.

Cianobacterias del embalse San Roque (Córdoba, Argentina Cyanobacteria of the San Roque reservoir (Córdoba, Argentina

Directory of Open Access Journals (Sweden)

Inés Claudia Daga

2011-12-01

Full Text Available Este trabajo es una contribución al conocimiento de las cianobacterias presentes en el embalse San Roque y forma parte de un estudio integral de la flora algal del mencionado embalse. Se citan 24 taxa correspondientes a los Ordenes Chroococcales (11, Nostocales (8 y Oscillatoriales (5. Synechocystis aquatilis, Gloeocapsa rupestris, Gomphosphaeria aponina, Chamaesiphon incrustans f. incrustans, Scytonema crispum, Tolypothrix distorta, Gloeotrichia pisum, Calothrix fusca, Trichodesmium lacustre, Geitlerinema splendidum, Lyngbya aestuarii y Borzia trilocularis son nuevas citas para la zona de estudio.This work is a contribution to the knowledge of the Cyanobacteria present in the San Roque reservoir and forms a part of an integral study of its algal flora. Twenty-four taxa are described and ilustrated: 11 Chroococcales, 8 Nostocales, and 5 Oscillatoriales. Synechocystis aquatilis, Gloeocapsa rupestris, Gomphosphaeria aponina, Chamaesiphon incrustans f. incrustans, Scytonema crispum, Tolypothrix distorta, Gloeotrichia pisum, Calothrix fusca, Trichodesmium lacustre, Geitlerinema splendidum, Lyngbya aestuarii and Borzia trilocularis.

Change in failure stress on the southern san andreas fault system caused by the 1992 magnitude = 7.4 landers earthquake.

Science.gov (United States)

Stein, R S; King, G C; Lin, J

1992-11-20

The 28 June Landers earthquake brought the San Andreas fault significantly closer to failure near San Bernardino, a site that has not sustained a large shock since 1812. Stress also increased on the San Jacinto fault near San Bernardino and on the San Andreas fault southeast of Palm Springs. Unless creep or moderate earthquakes relieve these stress changes, the next great earthquake on the southern San Andreas fault is likely to be advanced by one to two decades. In contrast, stress on the San Andreas north of Los Angeles dropped, potentially delaying the next great earthquake there by 2 to 10 years.

SOCIEDAD, PAZ Y GUERRA EN SAN AGUSTÍN

Directory of Open Access Journals (Sweden)

MIGUEL VERGARA VILLALOBOS

2017-12-01

Full Text Available Este trabajo analiza las nociones de sociedad, paz y guerra, en La ciudad de Dios, de San Agustín, a la que nos referimos principalmente según la edición bilingüe preparada por José Morán (1965. En una primera parte, a modo de introducción, se expone el argumento general del libro y se explica la teoría de las dos ciudades, la terrena y la de Dios. Enseguida se analiza la noción de sociedad, que se fundamenta en la justicia y en el interés común como camino para alcanzar la paz. Esto nos lleva a examinar la justicia, que para San Agustín es un concepto fundamental tanto en la ciudad terrena como en la ciudad de Dios. Teniendo este marco conceptual en cuanto la sociedad y la autoridad, se entra a discutir la paz, que representa uno de los aspectos centrales de la obra que comentamos. En contraste y como oposición a la paz se analiza la guerra; para nalizar con un tema cuyo origen clásicamente se atribuye a San Agustín, cual es la guerra justa.

The san san game as didatic resource of support in the discussions about regulatory nutrients in elementary education

Directory of Open Access Journals (Sweden)

Bárbara Della Antonia

2017-11-01

Full Text Available Leisure activities are used in the learning teaching process of the different areas of knowledge, to promote learning spontaneously and fun. For the area of Agrarian Sciences, which is a multidisciplinary area of study that can be approached from basic education to higher education, it is necessary to study the elaboration of didactic resources. Thus, this study aimed at the development of a didactic game in the field of agricultural sciences aimed at elementary education, whose strategy is to help in the understanding of contents related to the chemical composition of foods, focusing on regulatory nutrients. The game SAN SAN was applied and evaluated with elementary school students of a public school, bringing to the end of the process, positive results in the sense of motivation to study the subject, involvement of students in classes and contribution with an effective didactic resource.

77 FR 25128 - Amended Land Management Plans for the Angeles, Cleveland, Los Padres, and San Bernardino National...

Science.gov (United States)

2012-04-27

..., Los Padres, and San Bernardino National Forests, California AGENCY: Forest Service, USDA. ACTION... amendment of the Land Management Plans for the Angeles, Cleveland, Los Padres, and San Bernardino National... Angeles, Cleveland, Los Padres, and San Bernardino National Forests, collectively, ``four forests...

October 1986 San Salvador, El Salvador Images

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — At least 1,000 people killed, 10,000 injured, 200,000 homeless and severe damage in the San Salvador area. About 50 fatalities were the result of landslides in the...

The Eastern California Shear Zone as the northward extension of the southern San Andreas Fault

Science.gov (United States)

Thatcher, Wayne R.; Savage, James C.; Simpson, Robert W.

2016-01-01

Cluster analysis offers an agnostic way to organize and explore features of the current GPS velocity field without reference to geologic information or physical models using information only contained in the velocity field itself. We have used cluster analysis of the Southern California Global Positioning System (GPS) velocity field to determine the partitioning of Pacific-North America relative motion onto major regional faults. Our results indicate the large-scale kinematics of the region is best described with two boundaries of high velocity gradient, one centered on the Coachella section of the San Andreas Fault and the Eastern California Shear Zone and the other defined by the San Jacinto Fault south of Cajon Pass and the San Andreas Fault farther north. The ~120 km long strand of the San Andreas between Cajon Pass and Coachella Valley (often termed the San Bernardino and San Gorgonio sections) is thus currently of secondary importance and carries lesser amounts of slip over most or all of its length. We show these first order results are present in maps of the smoothed GPS velocity field itself. They are also generally consistent with currently available, loosely bounded geologic and geodetic fault slip rate estimates that alone do not provide useful constraints on the large-scale partitioning we show here. Our analysis does not preclude the existence of smaller blocks and more block boundaries in Southern California. However, attempts to identify smaller blocks along and adjacent to the San Gorgonio section were not successful.

San Diego Littoral Cell CRSMP Receiver Sites 2009

Data.gov (United States)

California Natural Resource Agency — A total of 27 possible placement sites (some with multiple placement footprints) are incorporated into this San Diego Coastal Regional Sediment Management Plan to...

San Diego Littoral Cell CRSMP Receiver Sites 2009

Data.gov (United States)

California Department of Resources — A total of 27 possible placement sites (some with multiple placement footprints) are incorporated into this San Diego Coastal Regional Sediment Management Plan to...

Magnetotelluric data collected to characterize aquifers in the San Luis Basin, New Mexico

Science.gov (United States)

Ailes, Chad E.; Rodriguez, Brian D.

2015-01-01

The U.S. Geological Survey is conducting a series of multidisciplinary studies of the San Luis Basin as part of the Geologic Framework of Rio Grande Basins project. Detailed geologic mapping, high-resolution airborne magnetic surveys, gravity surveys, magnetotelluric surveys, and hydrologic and lithologic data are being used to better understand the aquifers in the San Luis Basin. This report describes one north-south and two east-west regional magnetotelluric sounding profiles, acquired in June of 2010 and July and August of 2011, across the San Luis Basin in northern New Mexico. No interpretation of the data is included.

Waterbird nest monitoring program in San Francisco Bay (2005-10)

Science.gov (United States)

Ackerman, Joshua T.; Herzog, Mark P.

2012-01-01

Historically, Forster’s Terns (Sterna forsteri), American Avocets (Recurvirostra americana), and Black-necked Stilts (Himantopus mexicanus) were uncommon residents of San Francisco Bay, California (Grinnell and others, 1918; Grinnell and Wythe, 1927; Sibley, 1952). Presently, however, avocets and stilts are the two most abundant breeding shorebirds in San Francisco Bay (Stenzel and others, 2002; Rintoul and others, 2003). More than 4,000 avocets and 1,000 stilts, roughly 20 percent of their San Francisco Bay wintering populations, breed within the estuary, making San Francisco Bay the largest breeding area for these species on the Pacific Coast (Stenzel and others, 2002; Rintoul and others, 2003). Forster’s Terns were first observed breeding in the San Francisco Bay in 1948 (110 nests); they had increased to over 4000 individuals by the 1980s (Sibley, 1952; Gill, 1977; Harvey and others, 1992; Carter and others, 1990) and were estimated at 2000–3000 for 1998–2002; (Strong and others, 2004).It is hypothesized that the relatively large size of the current waterbird breeding populations is a result of the creation of artificial salt evaporation ponds from the 1930s through the 1950s (Gill, 1977; Goals Project, 1999). Until recently, these salt ponds and associated islands used by waterbirds for nesting have been managed relatively similarly and have supported large breeding waterbird populations. Recently, the South Bay Salt Pond Restoration Project has implemented plans to convert 50–90 percent of the 15,000 acres of salt ponds in the South San Francisco Bay back to tidal marsh habitat. Therefore, there is concern that the Restoration Project, while benefiting other native species, could negatively influence local breeding populations of waterbirds that are reliant on salt pond habitats for both breeding and foraging. A primary goal of the South Bay Salt Pond Restoration Project is to maintain current breeding waterbird populations (South Bay Salt Pond Long

Distribución del ocelote (Leopardus pardalis en San Luis Potosí, México Distribution of the ocelot (Leopardus pardalis in San Luis Potosí, Mexico

Directory of Open Access Journals (Sweden)

Jesús Manuel Martínez-Calderas

2011-09-01

Full Text Available Para definir la distribución geográfica del ocelote en el estado de San Luis Potosí, México, se obtuvieron nuevos registros de la especie. El estudio se realizó de enero de 2007 a abril de 2009. Se obtuvieron 41 registros de ocelotes por medio de entrevistas y trampeo-fotográfico. Los registros se localizaron en comunidades vegetales de selva baja caducifolia (37%, matorral submontano (22%, bosque de encino (15%, selva mediana (10%, selva alta perennifolia, bosque mesófilo de montaña, bosque de pino-encino y matorral desértico micrófilo (10%. La presencia de ocelotes se ubicó en los municipios de Ciudad del Maíz, El Naranjo, Cerritos, Guadalcázar, San Nicolás Tolentino y Ciudad Valles en de elevaciones de 38 a 2 400 m snm. Los resultados de esta investigación sugieren una distribución del ocelote más hacia el oeste del estado respecto a su distribución original. El presente estudio definió nuevas regiones con presencia de ocelotes que pueden ser consideradas en el desarrollo de estrategias de conservación de la especie en el estado de San Luis Potosí.To determine the geographic distribution of ocelot in the state of San Luis Potosí, Mexico, we obtained new records. The study was conducted from January 2007 to April 2009. We recorded 41 ocelot records by interviews and camera-trapping. Ocelots records were located in tropical deciduous forest (37%, semitropical thornscrub (22%, oak forest (15%, tropical forest (10%, tall tropical deciduous forest, desert scrub, pine-oak forest and clouded forest (10%. Ocelot records were located in the municipalities of Ciudad del Maíz, El Naranjo, Cerritos, Guadalcazar, San Nicolás Tolentino and Ciudad Valles where the elevation ranged from 38 to 2 400 m. The evidence of this research suggests that ocelot range is more extended to the west than its original geographical range. This study defined new regions with presence of ocelots that may be considered to develop conservation strategies

76 FR 6491 - San Diego County Water Authority Subregional Natural Community Conservation Program/Habitat...

Science.gov (United States)

2011-02-04

...] San Diego County Water Authority Subregional Natural Community Conservation Program/Habitat Conservation Plan, San Diego and Riverside Counties, CA; Final Environmental Impact Statement and Habitat... also announce the availability of the Water Authority's Subregional Natural Community Conservation...

[Psychiatric Hospital San Juan de Dios. One hundred years later].

Science.gov (United States)

Cocula-León, Horacio

2014-01-01

Mental health and psychiatric diseases have always attracted people's and health authorities' attention due to its magical approach, the lack of knowledge that surrounds them, and, at the same time, the religious fear they provoke. Both have played an important role in the history of humanity, of public health politics, and of physicians. The places where psychiatric patients were treated are of historical interest, because through the historical knowledge we can identify an approach from the science and the health policies that prevailed in each age. At the beginning of the 20th century, it was developed in México a new model of hospital care attention to psychiatric patients. La Casa de Salud San Juan de Dios para Pacientes Alienados is an example; the concept "alienated patients" suggests a social and cultural perspective. This paper presents a chronological type description of one of the major institutions involved in mental health care in México. Similarly, it shows a review of the events that affected the religious order San Juan de Dios from 1901 to 2012, when the hospitaller order was reinstated in México and established the Casa de Salud San Juan de Dios para Pacientes Alienados in the town of Zapopan, Jalisco, institution that exists up to the present day and keeps participating in the mental health care in the state of Jalisco, with the current name of Servicios de Salud San Juan de Dios.

Microbial diversity in restored wetlands of San Francisco Bay

Energy Technology Data Exchange (ETDEWEB)

Theroux, Susanna [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Hartman, Wyatt [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; He, Shaomei [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Univ. of Wisconsin, Madison, WI (United States); Tringe, Susannah [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.

2013-12-09

Wetland ecosystems may serve as either a source or a sink for atmospheric carbon and greenhouse gases. This delicate carbon balance is influenced by the activity of belowground microbial communities that return carbon dioxide and methane to the atmosphere. Wetland restoration efforts in the San Francisco Bay-Delta region may help to reverse land subsidence and possibly increase carbon storage in soils. However, the effects of wetland restoration on microbial communities, which mediate soil metabolic activity and carbon cycling, are poorly studied. In an effort to better understand the underlying factors which shape the balance of carbon flux in wetland soils, we targeted the microbial communities in a suite of restored and historic wetlands in the San Francisco Bay-Delta region. Using DNA and RNA sequencing, coupled with greenhouse gas monitoring, we profiled the diversity and metabolic potential of the wetland soil microbial communities along biogeochemical and wetland age gradients. Our results show relationships among geochemical gradients, availability of electron acceptors, and microbial community composition. Our study provides the first genomic glimpse into microbial populations in natural and restored wetlands of the San Francisco Bay-Delta region and provides a valuable benchmark for future studies.

San andreas fault zone head waves near parkfield, california.

Science.gov (United States)

Ben-Zion, Y; Malin, P

1991-03-29

Microearthquake seismograms from the borehole seismic network on the San Andreas fault near Parkfield, California, provide three lines of evidence that first P arrivals are "head" waves refracted along the cross-fault material contrast. First, the travel time difference between these arrivals and secondary phases identified as direct P waves scales linearly with the source-receiver distance. Second, these arrivals have the emergent wave character associated in theory and practice with refracted head waves instead of the sharp first breaks associated with direct P arrivals. Third, the first motion polarities of the emergent arrivals are reversed from those of the direct P waves as predicted by the theory of fault zone head waves for slip on the San Andreas fault. The presence of fault zone head waves in local seismic network data may help account for scatter in earthquake locations and source mechanisms. The fault zone head waves indicate that the velocity contrast across the San Andreas fault near Parkfield is approximately 4 percent. Further studies of these waves may provide a way of assessing changes in the physical state of the fault system.

Solar Feasibility Study May 2013 - San Carlos Apache Tribe

Energy Technology Data Exchange (ETDEWEB)

Rapp, Jim [Parametrix; Duncan, Ken [San Carlos Apache Tribe; Albert, Steve [Parametrix

2013-05-01

The San Carlos Apache Tribe (Tribe) in the interests of strengthening tribal sovereignty, becoming more energy self-sufficient, and providing improved services and economic opportunities to tribal members and San Carlos Apache Reservation (Reservation) residents and businesses, has explored a variety of options for renewable energy development. The development of renewable energy technologies and generation is consistent with the Tribe’s 2011 Strategic Plan. This Study assessed the possibilities for both commercial-scale and community-scale solar development within the southwestern portions of the Reservation around the communities of San Carlos, Peridot, and Cutter, and in the southeastern Reservation around the community of Bylas. Based on the lack of any commercial-scale electric power transmission between the Reservation and the regional transmission grid, Phase 2 of this Study greatly expanded consideration of community-scale options. Three smaller sites (Point of Pines, Dudleyville/Winkleman, and Seneca Lake) were also evaluated for community-scale solar potential. Three building complexes were identified within the Reservation where the development of site-specific facility-scale solar power would be the most beneficial and cost-effective: Apache Gold Casino/Resort, Tribal College/Skill Center, and the Dudleyville (Winkleman) Casino.

2010 Northern San Francisco Bay Area Lidar: Portions of Alameda, Contra Costa, Marin, Napa, San Francisco, Solano, and Sonoma Counties

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This Light Detection and Ranging (LiDAR) dataset is a survey of northern San Francisco Bay, California. The project area consists of approximately 437 square miles...

Inteligencia emocional y vínculo laboral en trabajadores del Centro San Camilo Emotional intelligence and engagement in San Camilo Centre workers

Directory of Open Access Journals (Sweden)

Cristina Liébana Presa

2012-06-01

Full Text Available Las organizaciones están comprometidas desde hace tiempo con la promoción de la salud y del bienestar de los trabajadores. Con este referente se realizó el presente estudio; el objetivo fue describir y analizar las asociaciones que existen entre las variables inteligencia emocional y engagement. La población fueron 150 trabajadores del Centro San Camilo. Los instrumentos de evaluación utilizados son la escala de Inteligencia Emocional (EIE-33, la escala de Inteligencia Emocional (EIE-25, el Trait Meta-Mood Scale (TMMS-24 y cuestionario de Utrecht Work Engagement Scale (UWES. Es un estudio descriptivo correlacional. En los trabajadores del Centro San Camilo existe asociación entre la inteligencia emocional y el engagement. Así la inteligencia emocional, entendida como la capacidad para adquirir habilidades o competencias para la adaptación de las demandas profesionales, potencia un estado mental positivo relacionado con el trabajo y ello repercute en la calidad asistencial y en la salud de la población atendida.For some time organizations are committed with health promotion and workers welfare. Under this concern this study has been conducted; the aim was to describe and analyse the existing associations between emotional intelligence and engagement variables. The population were 150 workers from San Camilo Centre. The assessment instruments used were the scale of Emotional Intelligence (EIE-33, the scale of Emotional Intelligence (EIE-25, the Trait Meta-Mood Scale (TMMS-25 and the questionnaire of Utrecht Work Engagement Scale (UWES. It is a descriptive correlational study. In San Camilo Centre workers there is association between emotional intelligence and engagement. Emotional intelligence, understood as the capacity to acquire skills or competencies for the adaptation to professional demands thus enhances a positive mental state work-related and this affects the quality of care and the assisted population health.

Miocene and Pleistocene mollusks from San Andres Island (Caribbean Sea, Colombia) and Paleogeographic considerations

International Nuclear Information System (INIS)

Diaz M, Juan Manuel; Garcia Llano, Cesar Fernando

2010-01-01

San Andres Island is the largest emerged portion of the oceanic archipelago of San Andres and Providencia, southwestern Caribbean Sea; it originated as a coralline atoll during Miocene times. The central and highest part of the island consists of a calcareous crest, the San Andres Formation, formed by Neogene lagoonal and reefal deposits. This crest is surrounded by a calcareous platform of Pleistocene age (San Luis Formation) which emerges only along the island coast, whereas its most part is submerged and covered by a Recent reef complex. Fossil material of molluscs from these two formations was collected in various sites throughout the island and taxonomically identified. In the four sites sampled in the San Andres Formation, material belonging to 19 gastropod and 37 bivalve species was obtained, most of them relatively well represented in other geologic formations of the Caribbean region that are stratigraphically situated between the upper Miocene and the middle Pliocene. Some elements occurring in this formation, such as Ostrea haitiensis, Meretrix dariena and Siphocypraea henekeni, were widely distributed in the Caribbean Miocene Province. In the San Luis Formation, material belonging to 18 gastropod and 11 bivalve species was obtained, most of them also represented in the Recent molluscan fauna of the region. The estimated age of this formation is Sangamonian, hence corresponding to similar formations occurring in Grand Cayman, Jamaica, Hispaniola, the Netherlands Antilles and other Caribbean islands, with which it also shows a great similarity in the composition of the molluscan fauna.

Clinical Evaluation of Perspiration Reducing Effects of a Kampo Formula, Shigyaku-san, on Palmoplantar Hidrosis

Directory of Open Access Journals (Sweden)

Fumino Ninomiya

2008-01-01

Full Text Available Palmoplantar hidrosis is common in patients who are susceptible to strains on the autonomic nervous system, and stress and mental strain have been proven to produce sweating in this population. Shigyaku-san (Sini san, TJ-35: Tsumura & Co. is effective for relieving stagnation of ‘liver Qi and vital energy’ in traditional Chinese medicine theory; this brings about improvement of palmoplantar hidrosis. The effect of Shigyaku-san on 40 patients was evaluated based on changes in palmoplantar sweat volume and skin temperature before and after stress loading. We also measured changes in the palmoplantar sweat volume and skin temperature due to stress load in 35 healthy controls who did not receive Shigyaku-san. Before treatment, the pre-stress sweat volume in patients was larger than that in healthy controls, however, after Shigyaku-san treatment, their pre-stress sweat volume decreased. With stress, the sweat volume increased in both patients and controls, but the net increase in the patients was larger than that in healthy controls. After Shigyaku-san treatment, the net increase of sweat volume due to stress was smaller than that of pretreatment, however, it did not show a significant difference with that of healthy controls. The palmoplantar skin temperature of the patients before treatment was lower than that of healthy controls. Palmoplantar skin temperature rose with stress loading in healthy controls, but decreased in pretreatment patients. Shigyaku-san treatment reduced the palmoplantar perspiration in palmoplantar hidrosis patients at rest and under stress. Furthermore, it also improved other serious complications, especially coldness of the extremities.

Potential field studies of the central San Luis Basin and San Juan Mountains, Colorado and New Mexico, and southern and western Afghanistan

Science.gov (United States)

Drenth, Benjamin John

This dissertation includes three separate chapters, each demonstrating the interpretive utility of potential field (gravity and magnetic) geophysical datasets at various scales and in various geologic environments. The locations of these studies are the central San Luis Basin of Colorado and New Mexico, the San Juan Mountains of southwestern Colorado, and southern and western Afghanistan. The San Luis Basin is the northernmost of the major basins that make up the Rio Grande rift, and interpretation of gravity and aeromagnetic data reveals patterns of rifting, rift-sediment thicknesses, distribution of pre-rift volcanic and sedimentary rocks, and distribution of syn-rift volcanic rocks. Syn-rift Santa Fe Group sediments have a maximum thickness of ˜2 km in the Sanchez graben near the eastern margin of the basin along the central Sangre de Cristo fault zone. Under the Costilla Plains, thickness of these sediments is estimated to reach ˜1.3 km. The Santa Fe Group sediments also reach a thickness of nearly 1 km within the Monte Vista graben near the western basin margin along the San Juan Mountains. A narrow, north-south-trending structural high beneath San Pedro Mesa separates the graben from the structural depression beneath the Costilla Plains. Aeromagnetic anomalies are interpreted to mainly reflect variations of remanent magnetic polarity and burial depth of the 5.3-3.7 Ma Servilleta basalt of the Taos Plateau volcanic field. Magnetic-source depth estimates indicate patterns of subsidence following eruption of the basalt and show that the Sanchez graben has been the site of maximum subsidence. One of the largest and most pronounced gravity lows in North America lies over the rugged San Juan Mountains in southwestern Colorado. A buried, low-density silicic batholith related to an Oligocene volcanic field coincident with the San Juan Mountains has been the accepted interpretation of the source of the gravity low since the 1970s. However, this interpretation was

SANS study of the structural evolution in NIPA/SA gel on dehydration

CERN Document Server

Sugiyama, M; Maeda, Y; Hara, K

2002-01-01

Mesoscopic structures of N-isopropylacryl-amide/sodium acrylate (NIPA/SA) gels with several water contents were investigated with a small-angle neutron scattering (SANS) method in order to make clear their structural evolution on dehydration. The evolution of the SANS profile with a decrease in the water content in the gel could be classified into three stages. In the beginning, there was no peak in the SANS profile except for the central part, which steadily intensified. With the further water dissipation, a side peak appeared at around 0.02 A sup - sup 1 , the intensity of which increased up to a certain water content and then decreased. These results indicate that the water dissipation in the NIPA/SA gel occurs inhomogeneously. (orig.)

76 FR 41811 - Kellaway Proposed Low-Effect Habitat Conservation Plan for the Morro Shoulderband Snail, San Luis...

Science.gov (United States)

2011-07-15

...] Kellaway Proposed Low-Effect Habitat Conservation Plan for the Morro Shoulderband Snail, San Luis Obispo... species in the community of Los Osos, San Luis Obispo County, California. The applicants would implement a... Los Osos, San Luis Obispo County, California. The applicants are requesting a permit for take of Morro...

Rare Plants - City of San Diego [ds455

Data.gov (United States)

California Natural Resource Agency — The Biological Monitoring Plan (BMP; Ogden 1996) for the Multiple Species Conservation Program (MSCP) was developed in 1996 and is a component of the City of San...

Deep permeability of the San Andreas Fault from San Andreas Fault Observatory at Depth (SAFOD) core samples

Science.gov (United States)

Morrow, Carolyn A.; Lockner, David A.; Moore, Diane E.; Hickman, Stephen H.

2014-01-01

The San Andreas Fault Observatory at Depth (SAFOD) scientific borehole near Parkfield, California crosses two actively creeping shear zones at a depth of 2.7 km. Core samples retrieved from these active strands consist of a foliated, Mg-clay-rich gouge containing porphyroclasts of serpentinite and sedimentary rock. The adjacent damage zone and country rocks are comprised of variably deformed, fine-grained sandstones, siltstones, and mudstones. We conducted laboratory tests to measure the permeability of representative samples from each structural unit at effective confining pressures, Pe up to the maximum estimated in situ Pe of 120 MPa. Permeability values of intact samples adjacent to the creeping strands ranged from 10−18 to 10−21 m2 at Pe = 10 MPa and decreased with applied confining pressure to 10−20–10−22 m2 at 120 MPa. Values for intact foliated gouge samples (10−21–6 × 10−23 m2 over the same pressure range) were distinctly lower than those for the surrounding rocks due to their fine-grained, clay-rich character. Permeability of both intact and crushed-and-sieved foliated gouge measured during shearing at Pe ≥ 70 MPa ranged from 2 to 4 × 10−22 m2 in the direction perpendicular to shearing and was largely insensitive to shear displacement out to a maximum displacement of 10 mm. The weak, actively-deforming foliated gouge zones have ultra-low permeability, making the active strands of the San Andreas Fault effective barriers to cross-fault fluid flow. The low matrix permeability of the San Andreas Fault creeping zones and adjacent rock combined with observations of abundant fractures in the core over a range of scales suggests that fluid flow outside of the actively-deforming gouge zones is probably fracture dominated.

75 FR 9921 - San Diego County Water Authority Natural Communities Conservation Program/Habitat Conservation...

Science.gov (United States)

2010-03-04

... Diego County Water Authority Natural Communities Conservation Program/Habitat Conservation Plan, San... the NCCP/HCP's conservation strategy. Covered Activities would include developing new water... permit application, and notice of public meetings. SUMMARY: The San Diego County Water Authority (Water...

A look inside the San Andreas Fault at Parkfield through vertical seismic profiling.

Science.gov (United States)

Chavarria, J Andres; Malin, Peter; Catchings, Rufus D; Shalev, Eylon

2003-12-05

The San Andreas Fault Observatory at Depth pilot hole is located on the southwestern side of the Parkfield San Andreas fault. This observatory includes a vertical seismic profiling (VSP) array. VSP seismograms from nearby microearthquakes contain signals between the P and S waves. These signals may be P and S waves scattered by the local geologic structure. The collected scattering points form planar surfaces that we interpret as the San Andreas fault and four other secondary faults. The scattering process includes conversions between P and S waves, the strengths of which suggest large contrasts in material properties, possibly indicating the presence of cracks or fluids.

Damage Detection Response Characteristics of Open Circuit Resonant (SansEC) Sensors

Science.gov (United States)

Dudley, Kenneth L.; Szatkowski, George N.; Smith, Laura J.; Koppen, Sandra V.; Ely, Jay J.; Nguyen, Truong X.; Wang, Chuantong; Ticatch, Larry A.; Mielnik, John J.

2013-01-01

The capability to assess the current or future state of the health of an aircraft to improve safety, availability, and reliability while reducing maintenance costs has been a continuous goal for decades. Many companies, commercial entities, and academic institutions have become interested in Integrated Vehicle Health Management (IVHM) and a growing effort of research into "smart" vehicle sensing systems has emerged. Methods to detect damage to aircraft materials and structures have historically relied on visual inspection during pre-flight or post-flight operations by flight and ground crews. More quantitative non-destructive investigations with various instruments and sensors have traditionally been performed when the aircraft is out of operational service during major scheduled maintenance. Through the use of reliable sensors coupled with data monitoring, data mining, and data analysis techniques, the health state of a vehicle can be detected in-situ. NASA Langley Research Center (LaRC) is developing a composite aircraft skin damage detection method and system based on open circuit SansEC (Sans Electric Connection) sensor technology. Composite materials are increasingly used in modern aircraft for reducing weight, improving fuel efficiency, and enhancing the overall design, performance, and manufacturability of airborne vehicles. Materials such as fiberglass reinforced composites (FRC) and carbon-fiber-reinforced polymers (CFRP) are being used to great advantage in airframes, wings, engine nacelles, turbine blades, fairings, fuselage structures, empennage structures, control surfaces and aircraft skins. SansEC sensor technology is a new technical framework for designing, powering, and interrogating sensors to detect various types of damage in composite materials. The source cause of the in-service damage (lightning strike, impact damage, material fatigue, etc.) to the aircraft composite is not relevant. The sensor will detect damage independent of the cause

San Francisco Bay, California 1 arc-second DEM

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The 1-second San Francisco Bay, California Elevation Grid provides bathymetric data in ASCII raster format of 1-second resolution in geographic coordinates. This...

San Francisco Bay Multi-beam Bathymetry: Area A

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — These multi-beam bathymetric data were collected over shallow subtidal areas in the San Francisco Bay estuary system. Bathymetric and acoustic backscatter data were...

75 FR 17430 - Hopper Mountain, Bitter Creek, and Blue Ridge National Wildlife Refuges, Kern, San Luis Obispo...

Science.gov (United States)

2010-04-06

...] Hopper Mountain, Bitter Creek, and Blue Ridge National Wildlife Refuges, Kern, San Luis Obispo, Tulare... Wildlife Refuges (NWRs) located in Kern, San Luis Obispo, Tulare, and Ventura counties of California. We... developing a CCP for Hopper Mountain, Bitter Creek, and Blue Ridge NWRs in Kern, San Luis Obispo, Tulare, and...

Width and dip of the southern San Andreas Fault at Salt Creek from modeling of geophysical data

Science.gov (United States)

Langenheim, Victoria; Athens, Noah D.; Scheirer, Daniel S.; Fuis, Gary S.; Rymer, Michael J.; Goldman, Mark R.; Reynolds, Robert E.

2014-01-01

We investigate the geometry and width of the southernmost stretch of the San Andreas Fault zone using new gravity and magnetic data along line 7 of the Salton Seismic Imaging Project. In the Salt Creek area of Durmid Hill, the San Andreas Fault coincides with a complex magnetic signature, with high-amplitude, short-wavelength magnetic anomalies superposed on a broader magnetic anomaly that is at least 5 km wide centered 2–3 km northeast of the fault. Marine magnetic data show that high-frequency magnetic anomalies extend more than 1 km west of the mapped trace of the San Andreas Fault. Modeling of magnetic data is consistent with a moderate to steep (> 50 degrees) northeast dip of the San Andreas Fault, but also suggests that the sedimentary sequence is folded west of the fault, causing the short wavelength of the anomalies west of the fault. Gravity anomalies are consistent with the previously modeled seismic velocity structure across the San Andreas Fault. Modeling of gravity data indicates a steep dip for the San Andreas Fault, but does not resolve unequivocally the direction of dip. Gravity data define a deeper basin, bounded by the Powerline and Hot Springs Faults, than imaged by the seismic experiment. This basin extends southeast of Line 7 for nearly 20 km, with linear margins parallel to the San Andreas Fault. These data suggest that the San Andreas Fault zone is wider than indicated by its mapped surface trace.

Earthquake geology and paleoseismology of major strands of the San Andreas fault system: Chapter 38

Science.gov (United States)

Rockwell, Thomas; Scharer, Katherine M.; Dawson, Timothy E.

2016-01-01

The San Andreas fault system in California is one of the best-studied faults in the world, both in terms of the long-term geologic history and paleoseismic study of past surface ruptures. In this paper, we focus on the Quaternary to historic data that have been collected from the major strands of the San Andreas fault system, both on the San Andreas Fault itself, and the major subparallel strands that comprise the plate boundary, including the Calaveras-Hayward- Rogers Creek-Maacama fault zone and the Concord-Green Valley-Bartlett Springs fault zone in northern California, and the San Jacinto and Elsinore faults in southern California. The majority of the relative motion between the Pacific and North American lithospheric plates is accommodated by these faults, with the San Andreas slipping at about 34 mm/yr in central California, decreasing to about 20 mm/yr in northern California north of its juncture with the Calaveras and Concord faults. The Calaveras-Hayward-Rogers Creek-Maacama fault zone exhibits a slip rate of 10-15 mm/yr, whereas the rate along the Concord-Green Valley-Bartlett Springs fault zone is lower at about 5 mm/yr. In southern California, the San Andreas exhibits a slip rate of about 35 mm/yr along the Mojave section, decreasing to as low as 10-15 mm/yr along its juncture with the San Jacinto fault, and about 20 mm/yr in the Coachella Valley. The San Jacinto and Elsinore fault zones exhibit rates of about 15 and 5 mm/yr, respectively. The average recurrence interval for surface-rupturing earthquakes along individual elements of the San Andreas fault system range from 100-500 years and is consistent with slip rate at those sites: higher slip rates produce more frequent or larger earthquakes. There is also evidence of short-term variations in strain release (slip rate) along various fault sections, as expressed as “flurries” or clusters of earthquakes as well as periods of relatively fewer surface ruptures in these relatively short records. This

SANS analysis of aqueous ionic perfluoropolyether micelles

CERN Document Server

Gambi, C M C; Chittofrati, A; Pieri, R; Baglioni, P; Teixeira, J

2002-01-01

Preliminary SANS results of ionic chlorine terminated perfluoropolyether micelles in water are given. The experimental spectra have been analyzed by a two-shell ellipsoidal model for the micellar form factor and a screened Coulombic plus hard-sphere repulsion potential for the structure factor. (orig.)

Stability of embossed PEI-(PSS-PDADMAC) 20 multilayer films versus storage time and versus a change in ionic strength

Science.gov (United States)

Ladhari, Nadia; Hemmerlé, Joseph; Haikel, Youssef; Voegel, Jean-Claude; Schaaf, Pierre; Ball, Vincent

2008-12-01

The use of microstructured films increased markedly in many areas of science and technology, notably in the design of microfluidic channels and in the design of parallel biosensing arrays. The concept of imprinting polyelectrolyte multilayer films (PEMs) has been introduced recently [C. Gao, B. Wang, J. Feng, J. Shen, Macromolecules 37 (2004) 8836]. These irreversibly imprinted films, obtained by plastic deformation, have to keep their size and shape after contact with fluids having physicochemical properties comparable to those of biological fluids in order to be used as microfluidic channels. We demonstrate herein that PEI-(PSS-PDADMAC) 20 PEMs built-up by the spray deposition from NaCl 1 M solutions and subsequently imprinted with polydimethylsiloxane stamps keep their morphology over time (up to 9 months) when stored in the dry state. In addition the depth of the imprinted channels does not change over this time duration. When the embossed films are immersed in NaCl 0.15 M solutions, mimicking biological fluids, the depth of the imprinted channels also does not significantly change. But, when the imprinted films prepared in the presence of 1 M NaCl are subsequently dipped in a 4 M NaCl solution, partial film loss and subsequent disappearance of the imprinted channels are observed. An explanation for these findings is furnished by means of FTIR spectroscopy in the attenuated total reflection mode (ATR-FTIR). These observations should offer large opportunities for the use of the imprinted multilayer films as microfluidic channels.

Poziv: Duhovnost i san. San o oružju Franje Asiškoga

OpenAIRE

Balajić, Siniša

2009-01-01

San o oružju Franje Asiškoga doima se važnim elemenatom u proučavanju, ne toliko poziva Franje Asiškoga, koliko poziva uopće. Budući da se analizom i interpretacijom snova bave antropologija, psihologija, filozofija, teologija, itd., koncept razumijevanja ovoga sna uokviruje različita znanstvena (antropologija, psihologija) i teorijska načela (filozofija, teologija-duhovnost). Svjesni smo da proučavanje nečijega života, a pogotovo proučavanje nečijih snova, nije nimalo la...

77 FR 36041 - San Antonio Central Railroad, L.L.C.-Lease Exemption-Port Authority of San Antonio

Science.gov (United States)

2012-06-15

... control of SAC upon SAC becoming a Class III rail carrier. As a result of this transaction, SAC will provide common carrier rail service over the rail lines owned by the Port in the East Kelly Railport (the... and operate approximately four miles of rail line owned by the Port Authority of San Antonio (the Port...

Anthropogenic influences on shoreline and nearshore evolution in the San Francisco Bay coastal system

Science.gov (United States)

Dallas, K.L.; Barnard, P.L.

2011-01-01

Analysis of four historical bathymetric surveys over a 132-year period has revealed significant changes to the morphology of the San Francisco Bar, an ebb-tidal delta at the mouth of San Francisco Bay estuary. From 1873 to 2005 the San Francisco Bar vertically-eroded an average of 80 cm over a 125 km2 area, which equates to a total volume loss of 100 ± 52 million m3 of fine- to coarse-grained sand. Comparison of the surveys indicates the entire ebb-tidal delta contracted radially, with the crest moving landward an average of 1 km. Long-term erosion of the ebb-tidal delta is hypothesized to be due to a reduction in the tidal prism of San Francisco Bay and a decrease in coastal sediment supply, both as a result of anthropogenic activities. Prior research indicates that the tidal prism of the estuary was reduced by 9% from filling, diking, and sedimentation. Compilation of historical records dating back to 1900 reveals that a minimum of 200 million m3 of sediment has been permanently removed from the San Francisco Bay coastal system through dredging, aggregate mining, and borrow pit mining. Of this total, ~54 million m3 of sand-sized or coarser sediment was removed from central San Francisco Bay. With grain sizes comparable to the ebb-tidal delta, and its direct connection to the bay mouth, removal of sediments from central San Francisco Bay may limit the sand supply to the delta and open coast beaches. SWAN wave modeling illustrates that changes to the morphology of the San Francisco Bar have altered the alongshore wave energy distribution at adjacent Ocean Beach, and thus may be a significant factor in a persistent beach erosion ‘hot spot’ occurring in the area. Shoreline change analyses show that the sandy shoreline in the shadow of the ebb-tidal delta experienced long-term (1850s/1890s to 2002) and short-term (1960s/1980s to 2002) accretion while the adjacent sandy shoreline exposed to open-ocean waves experienced long-term and short-term erosion. Therefore

75 FR 11194 - San Diego County Water Authority Natural Communities Conservation Program/Habitat Conservation...

Science.gov (United States)

2010-03-10

... Diego County Water Authority Natural Communities Conservation Program/Habitat Conservation Plan, San... meetings for the San Diego County Water Authority's (Water Authority/Applicant) draft Natural Communities Conservation Plan (NCCP)/Habitat Conservation Plan (HCP) prepared in application to us for an incidental take...

Isotopic Evidence of Nitrate Sources and its Relationship to Algae in the San Joaquin River, California

Science.gov (United States)

Silva, S. R.; Kendall, C.; Young, M. B.; Stringfellow, W. T.; Borglin, S. E.; Kratzer, C. R.; Dahlgren, R. A.; Schmidt, C.; Rollog, M. E.

2007-12-01

Many competing demands have been placed on the San Joaquin River including deep water shipping, use as agricultural and drinking water, transport of agricultural and urban runoff, and recreation. These long-established demands limit the management options and increase the importance of understanding the river dynamics. The relationships among sources of water, nitrate, and algae in the San Joaquin River must be understood before management decisions can be made to optimize aquatic health. Isotopic analyses of water samples collected along the San Joaquin River in 2005-2007 have proven useful in assessing these relationships: sources of nitrate, the productivity of the San Joaquin River, and the relationship between nitrate and algae in the river. The San Joaquin River receives water locally from wetlands and agricultural return flow, and from three relatively large tributaries whose headwaters are in the Sierra Nevada. The lowest nitrate concentrations occur during periods of high flow when the proportion of water from the Sierra Nevada is relatively large, reflecting the effect of dilution from the big tributaries and indicating that a large fraction of the nitrate is of local origin. Nitrogen isotopes of nitrate in the San Joaquin River are relatively high (averaging about 12 per mil), suggesting a significant source from animal waste or sewage and/or the effects of denitrification. The d15N of nitrate varies inversely with concentration, indicating that these high isotopic values are also a local product. The d15N values of nitrate from most of the local tributaries is lower than that in the San Joaquin suggesting that nitrate from these tributaries does not account for a significant fraction of nitrate in the river. The source of the non-tributary nitrate must be either small unmeasured surface inputs or groundwater. To investigate whether groundwater might be a significant source of nitrate to the San Joaquin River, groundwater samples are being collected

Proceedings of the Fourth Social Aspects and Recreation Research Symposium: February 4-6, 2004, San Francisco, California

Science.gov (United States)

Patrick T. Tierney; Deborah J. (Tech. coords.) Chavez

2004-01-01

The Fourth Social Aspects and Recreation Research (SARR) Symposium was held February 4-6, 2004 in San Francisco, California at the Presidio of San Francisco, a component of Golden Gate National Recreation Area and at San Francisco State University. The theme was: Linking People to the Outdoors: Connections for Healthy Lands, People and Communities.

Structure analyses of swollen rubber-carbon black systems by contrast variation SANS

International Nuclear Information System (INIS)

Takenaka, Mikihito; Nishitsuji, Shotaro; Fujii, Sumiaki; Amino, Naoya; Ishikawa, Yasuhiro; Yamaguchi, Daisuke; Koizumi, Satoshi

2010-01-01

The polymer layers adsorbed on carbon black (CB) aggregates in rubber/CB systems have been investigated with contrast variation small-angle neutron scattering (SANS) method. Specimens were swollen by toluene/deuterated toluene solvents having various scattering length densities and their scattering intensities were measured with SANS. The contrast variation SANS for the specimens yielded partial scattering functions: the scattering function for polymer-polymer correlation S pp (q), the scattering function for CB- CB correlation S cc (q), and the scattering function for polymer- CB correlation S pc (q). The analyses of the partial scattering functions explored the existence of dense polymer layers around CB aggregates. Several characteristic parameters are estimated from the analyses, such as the size of aggregates, the thickness of layers, and the volume fractions of polymer of layers and matrix. (author)

Radionuclide concentrations in fish collected from Jemez, Nambe, and San Ildefonso Tribal Lakes

International Nuclear Information System (INIS)

Fresquez, P.R.; Armstrong, D.R.; Salazar, J.G.

1995-02-01

Radionuclide concentrations ( 90 Sr, 137 Cs, 238 Pu, 239 Pu,and total uranium) were determined in fish collected from Jemez, Nambe, and San Ildefonso tribal lakes. With the exception of 137 Cs, all other radionuclides were not significantly different in (stocked) rainbow trout collected from Jemez and Nambe as compared with game fish collected from Abiquiu, Heron, and El Vado Reservoirs. Although 137 Cs levels in trout from Jemez (3.2 x 10 -2 pCi per dry gram) and Nambe (7.5 x 10 -2 pCi per dry gram) were significantly higher than 137 Cs concentrations in fish from Abiquiu, Heron, and El Vado, they were still well below the regional statistical (worldwide fallout) reference level (i.e., -2 pCi per dry gram). Game and nongame fish collected from San Ildefonso contained higher and significantly higher concentrations of uranium, respectively, as compared with fish collected from Abiquiu, Heron, and El Vado. The higher uranium concentrations in fish from San Ildefonso as compared with fish from Abiquiu, Heron, and El Vado were attributed to the higher natural soil uranium contents in the area as compared with the geology of the area upstream of San Ildefonso. The effective (radiation) dose equivalent (EDE) from consuming 46 lb of game fish from Jemez, Nambe, and San Ildefonso lakes, after natural background has been subtracted, was 0.013 (±0.002), 0.019 (±0.012), and 0.017 (±0.028) mrem/yr, respectively. Similarly, the EDE from consuming nongame fish from San Ildefonso was 0.0092 (±0.0084) mrem/yr. The highest calculated dose, based on the mean + 2 standard deviation (95% confidence level), was 0.073 mrem/yr; this was <0.08% of the International Commission on Radiological Protection permissible dose limit for protecting members of the public

SANS-polymer and functional materials with neutron in Indonesia. Progress report on the collaboration activities?

International Nuclear Information System (INIS)

Ikram, A.; Gunawan; Sukirman, E.; Ridwan; Jahja, A.K.

2000-01-01

Activities on SANS-polymer collaboration program are reported. This paper presents SANS-data from Sodium Dodecyl Sulphate that have been obtained using BATAN's SANS machine in Serpong. Reports are also presented about activities in the groups for functional materials structural determination which includes magnetic, HTc superconducting and superionic conducting materials. Discussions are also given towards the way the collaboration activities were carried out in the last three years as well as impact of neutron scattering facility conditions in Indonesia. (author)

Hydrology of the middle San Pedro area, southeastern Arizona

Science.gov (United States)

Cordova, Jeffrey T.; Dickinson, Jesse; Beisner, Kimberly R.; Hopkins, Candice B.; Kennedy, Jeffrey R.; Pool, Donald R.; Glenn, Edward P.; Nagler, Pamela L.; Thomas, Blakemore E.

2015-05-05

In the middle San Pedro Watershed in southeastern Arizona, groundwater is the primary source of water supply for municipal, domestic, industrial, and agricultural use. The watershed comprises two smaller subareas, the Benson subarea and the Narrows-Redington subarea. Early 21st century projections for heavy population growth in the watershed have not yet become a reality, but increased groundwater withdrawals could have undesired consequences - such as decreased base flow to the San Pedro River, and groundwater-level declines - that would lead to the need to deepen existing wells. This report describes the hydrology, hydrochemistry, water quality, and development of a groundwater budget for the middle San Pedro Watershed, focusing primarily on the elements of groundwater movement that could be most useful for the development of a groundwater modelPrecipitation data from Tombstone, Arizona, and base flow at the stream-gaging station on the San Pedro River at Charleston both show relatively dry periods during the 1960s through the mid-1980s and in the mid-1990s to 2009, and wetter periods from the mid-1980s through the mid-1990s. Water levels in four out of five wells near the mountain fronts show cyclical patterns of recharge, with rates of recharge greatest in the early 1980s through the mid-1990s. Three wells near the San Pedro River recorded their lowest levels during the 1950s to the mid-1960s. The water-level record from one well, completed in the confined part of the coarse-grained lower basin fill, showed a decline of approximately 21 meters.Annual flow of the San Pedro River, measured at the Charleston and Redington gages, has decreased since the 1940s. The median annual streamflow and base flow at the gaging station on the river near Tombstone has decreased by 50 percent between the periods 1968–1986 and 1997–2009. Estimates of streamflow infiltration along the San Pedro River during 1914–2009 have decreased 44 percent, with the largest decreases in

San Juanico, BCS, Mexico, hybrid electric plant renewable energies in the rural communities development; Planta electrica hibrida San Juanico, B.C.S., Mexico, las energias renovables en el desarrollo de las comunidades rurales

Energy Technology Data Exchange (ETDEWEB)

Lopez Rios, Serafin [Gerencia de Proyectos Geotermoelectricos, Comision Federal de Electricidad (Mexico)

1999-08-01

The hybrid electric plant of San Juanico, B.C.S., Mexico, is described in terms of its environmental goals, operating process and contribution to the development of that rural community of the Baja California Peninsula. San Juanico hybrid electric plant is organized in three electrical generation systems that work in parallel: one uses solar energy, another wind energy and a third one uses diesel fuel. [Spanish] Se describe la planta hibrida de San Juanico, BCS, Mexico, en terminos de los objetivos ambientales que condujeron a su realizacion, asi como de su proceso operativo y de la participacion que tiene en el desarrollo de esa comunidad rural de la peninsula de Baja California, Mexico. La planta hibrida de San Juanico esta constituida por tres sistemas de generacion de electrcicidad que operan en paralelo: uno utiliza energia radiante del sol, otro energia del viento y un tercero utiliza diesel.

78 FR 53113 - Approval and Promulgation of Implementation Plans; California; San Joaquin Valley; Contingency...

Science.gov (United States)

2013-08-28

...] Approval and Promulgation of Implementation Plans; California; San Joaquin Valley; Contingency Measures for... California to address Clean Air Act nonattainment area contingency measure requirements for the 1997 annual... Air Act Requirements for Contingency Measures III. Review of the Submitted San Joaquin Valley PM 2.5...

Response of the Cottonwood Leaf Beetle (Coleoptera: Chrysomelidae) to Bacillus thuringiensis var. san diego

Science.gov (United States)

Leah S. Bauer

1990-01-01

A standardized laboratory bioassay was used to quantify the lethal and sub-lethal responses of larval and adult cottonwood leaf beetles, Chrysomela scripta F., to Bacillus thuringiensis var. san diego, formulated as M-One standard powder (Mycogen Corporation, San Diego). The median lethal concentration (LC

San Diego, California 1/3 arc-second DEM

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The 1/3-second San Diego, California Elevation Grid provides bathymetric data in ASCII raster format of 1/3-second resolution in geographic coordinates. This grid is...

LOD First Estimates In 7406 SLR San Juan Argentina Station

Science.gov (United States)

Pacheco, A.; Podestá, R.; Yin, Z.; Adarvez, S.; Liu, W.; Zhao, L.; Alvis Rojas, H.; Actis, E.; Quinteros, J.; Alacoria, J.

2015-10-01

In this paper we show results derived from satellite observations at the San Juan SLR station of Felix Aguilar Astronomical Observatory (OAFA). The Satellite Laser Ranging (SLR) telescope was installed in early 2006, in accordance with an international cooperation agreement between the San Juan National University (UNSJ) and the Chinese Academy of Sciences (CAS). The SLR has been in successful operation since 2011 using NAOC SLR software for the data processing. This program was designed to calculate satellite orbits and station coordinates, however it was used in this work for the determination of LOD (Length Of Day) time series and Earth Rotation speed.

Merchandising of cigarettes in San Francisco pharmacies: 27 years later.

Science.gov (United States)

Eule, B; Sullivan, M K; Schroeder, S A; Hudmon, K S

2004-12-01

To estimate changes since 1976 in the proportion of San Francisco pharmacies that sell cigarettes and to characterise the advertising of cigarettes and the merchandising of non-prescription nicotine replacement therapy (NRT) products in these retail establishments. 100 randomly selected San Francisco pharmacies were visited in 2003. Pharmacies were characterised based on the sale of cigarettes, advertising for cigarettes, and the merchandising of non-prescription NRT products. In 2003, 61% of pharmacies sold cigarettes, a significant decrease compared to 89% of pharmacies selling cigarettes in 1976 (p merchandise the primary known risk factor for death in the USA.

Stress diffusion along the san andreas fault at parkfield, california.

Science.gov (United States)

Malin, P E; Alvarez, M G

1992-05-15

Beginning in January 1990, the epicenters of microearthquakes associated with a 12-month increase in seismicity near Parkfield, California, moved northwest to southeast along the San Andreas fault. During this sequence of events, the locally variable rate of cumulative seismic moment increased. This increase implies a local increase in fault slip. These data suggest that a southeastwardly diffusing stress front propagated along the San Andreas fault at a speed of 30 to 50 kilometers per year. Evidently, this front did not load the Parkfield asperities fast enough to produce a moderate earthquake; however, a future front might do so.

Approches plurielles du nom sans déterminant distributions, interprétations, fonctions

CERN Document Server

Prescod, Paula

2017-01-01

Réunies sous des perspectives plurielles, les contributions de cet ouvrage fournissent des appréciations diverses des distributions, interprétations et fonctions du nom sans déterminant. La pluralité des outils d'analyse adoptés permet de faire émerger le caractère composite des noms sans déterminant dans diverses langues.

Educational intervention on pregnancy in adolescence. “San Francisco” Consejo Popular. Venezuela

OpenAIRE

Niurka Fleites Santana; Yosmel Álvarez González; Iván Arlé González Duque; Jayce Díaz Díaz

2015-01-01

Background:The studies accomplished in the worldwide space on pregnancy in adolescence demonstrate the need of an integral attention that would help the family in young people's education.Objective: to implement a program of educational intervention that contribute to modify young people's knowledges on pregnancy in adolescence.Methods: Study of educational intervention in teens of San Francisco community, belonging to the Municipality of Agua Blanca, San Francisco clinic, Portuguesa State, d...

Interaction of the san jacinto and san andreas fault zones, southern california: triggered earthquake migration and coupled recurrence intervals.

Science.gov (United States)

Sanders, C O

1993-05-14

Two lines of evidence suggest that large earthquakes that occur on either the San Jacinto fault zone (SJFZ) or the San Andreas fault zone (SAFZ) may be triggered by large earthquakes that occur on the other. First, the great 1857 Fort Tejon earthquake in the SAFZ seems to have triggered a progressive sequence of earthquakes in the SJFZ. These earthquakes occurred at times and locations that are consistent with triggering by a strain pulse that propagated southeastward at a rate of 1.7 kilometers per year along the SJFZ after the 1857 earthquake. Second, the similarity in average recurrence intervals in the SJFZ (about 150 years) and in the Mojave segment of the SAFZ (132 years) suggests that large earthquakes in the northern SJFZ may stimulate the relatively frequent major earthquakes on the Mojave segment. Analysis of historic earthquake occurrence in the SJFZ suggests little likelihood of extended quiescence between earthquake sequences.

Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion.

Science.gov (United States)

Lee, Hyun Ju; Lee, Se Guen; Oh, Eun Jung; Chung, Ho Yun; Han, Sang Ik; Kim, Eun Jung; Seo, Song Yi; Ghim, Han Do; Yeum, Jeong Hyun; Choi, Jin Hyun

2011-11-01

Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH(4)) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49 mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH(4). PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion. Copyright © 2011 Elsevier B.V. All rights reserved.

San Joaquin Valley Aerosol Health Effects Research Center (SAHERC)

Data.gov (United States)

Federal Laboratory Consortium — At the San Joaquin Valley Aerosol Health Effects Center, located at the University of California-Davis, researchers will investigate the properties of particles that...

Off-fault seismicity suggests creep below 10 km on the northern San Jacinto Fault

Science.gov (United States)

Cooke, M. L.; Beyer, J. L.

2017-12-01

Within the San Bernardino basin, CA, south of the juncture of the San Jacinto (SJF) and San Andreas faults (SAF), focal mechanisms show normal slip events that are inconsistent with the interseismic strike-slip loading of the region. High-quality (nodal plane uncertainty faults [Anderson et al., 2004]. However, the loading of these normal slip events remains enigmatic because the region is expected to have dextral loading between large earthquake events. These enigmatic normal slip events may be loaded by deep (> 10 km depth) spatially creep along the northern SJF. Steady state models show that over many earthquake cycles, the dextral slip rate on the northern SJF increases southward, placing the San Bernardino basin in extension. In the absence of recent large seismic events that could produce off-fault normal focal mechanisms in the San Bernardino basin, non-uniform deep aseismic slip on the SJF could account for this seismicity. We develop interseismic models that incorporate spatially non-uniform creep below 10 km on the SJF based on steady-state slip distribution. These model results match the pattern of deep normal slip events within the San Bernardino basin. Such deep creep on the SJF may not be detectable from the geodetic signal due to the close proximity of the SAF, whose lack of seismicity suggests that it is locked to 20 km. Interseismic models with 15 km locking depth on both faults are indistinguishable from models with 10 km locking depth on the SJF and 20 km locking depth on the SAF. This analysis suggests that the microseismicity in our multi-decadal catalog may record both the interseismic dextral loading of the region as well as off-fault deformation associated with deep aseismic creep on the northern SJF. If the enigmatic normal slip events of the San Bernardino basin are included in stress inversions from the seismic catalog used to assess seismic hazard, the results may provide inaccurate information about fault loading in this region.

Yi-gan san restores behavioral alterations and a decrease of brain glutathione level in a mouse model of schizophrenia.

Science.gov (United States)

Makinodan, Manabu; Yamauchi, Takahira; Tatsumi, Kouko; Okuda, Hiroaki; Noriyama, Yoshinobu; Sadamatsu, Miyuki; Kishimoto, Toshifumi; Wanaka, Akio

2009-01-01

The traditional Chinese herbal medicine yi-gan san has been used to cure neuropsychological disorders. Schizophrenia can be one of the target diseases of yi-gan san. We aimed at evaluating the possible use of yi-gan san in improving the schizophrenic symptoms of an animal model. Yi-gan san or distilled water was administered to mice born from pregnant mice injected with polyinosinic-polycytidilic acid or phosphate buffered saline. The former is a model of schizophrenia based on the epidemiological data that maternal infection leads to psychotic disorders including schizophrenia in the offspring. Prepulse inhibition and sensitivity to methamphetamine in open field tests were analyzed and the total glutathione content of whole brains was measured. Yi-gan san reversed the decrease in prepulse inhibition, hypersensitivity to methamphetamine and cognitive deficits found in the model mice to the level of control mice. Total glutathione content in whole brains was reduced in the model mice but was restored to normal levels by yi-gan san treatment. These results suggest that yi-gan san may have ameliorating effects on the pathological symptoms of schizophrenia.

33 CFR 165.1141 - Safety Zone; San Clemente 3 NM Safety Zone, San Clemente Island, CA.

Science.gov (United States)

2010-07-01

...) Location. The following area is a safety zone: All waters of the Pacific Ocean surrounding San Clemente Island, from surface to bottom, extending from the high tide line on the island seaward 3 NM. The zone... 3 NM from the high tide line to 33°02.82′ N, 118°30.65′ W; thence 33°01.29′ N, 118°33.88′ W; thence...

Local geomagnetic events associated with displacements on the san andreas fault.

Science.gov (United States)

Breiner, S; Kovach, R L

1967-10-06

The piezomagnetic properties of rock suggest that a change in subsurface stress will manifest itself as a change in the magnetic susceptibility and remanent magnetization and hence the local geomagnetic field. A differential array of magnetometers has been operating since late 1965 on the San Andreas fault in the search for piezomagnetic signals under conditions involving active fault stress. Local changes in the geomagnetic field have been observed near Hollister, California, some tens of hours preceding the onset of abrupt creep displacement on the San Andreas fault.

People's Front in Defence of Land, San Salvador Atenco: A testimony

OpenAIRE

Martha Pérez Pineda

2011-01-01

Martha Pérez Pineda gives her statement of the Peoples Front in Defence of the Land (The Peoples Front in Defence of Land (Frente del Pueblo en Defensa de la Tierra, FPDT) was formed in 2002, by residents of San Salvador Atenco, to resist their forced displacement by the federal government of Mexico and Estado de Mexico. The government planned to displace them to make way for the new Mexico City Airport. The people of San Salvador Atenco refused and battled, the most common fights were disput...

San Lorenzo and the Poggendorff Illusion in Ravenna

Directory of Open Access Journals (Sweden)

Olga Daneyko

2011-06-01

Full Text Available In the Mausoleum of Galla Placidia (Ravenna, Italy, the San Lorenzo lunette shows two peculiar visual effects: a transparency effect of gold seen through gold and perceptual collinearity between two parts of a cross which are physically misaligned. Both effects are found within the area of the halo surrounding the saint's head. In this work we addressed the problem posed by the physical misalignment of the cross. Our hypothesis is that the physical misalignment went unnoticed throughout history because the artist produced a perceptual alignment to correct for the Poggendorff illusion. Hence, we asked observers to align two ends of a cross in a reproduction showing the silhouette of San Lorenzo's torso holding the cross. Results support our hypothesis: both direction and magnitude of adjustments comply with the alignment in the original mosaic.

Direct interaction of the Usher syndrome 1G protein SANS and myomegalin in the retina.

Science.gov (United States)

Overlack, Nora; Kilic, Dilek; Bauss, Katharina; Märker, Tina; Kremer, Hannie; van Wijk, Erwin; Wolfrum, Uwe

2011-10-01

The human Usher syndrome (USH) is the most frequent cause of combined hereditary deaf-blindness. USH is genetically heterogeneous with at least 11 chromosomal loci assigned to 3 clinical types, USH1-3. We have previously demonstrated that all USH1 and 2 proteins in the eye and the inner ear are organized into protein networks by scaffold proteins. This has contributed essentially to our current understanding of the function of USH proteins and explains why defects in proteins of different families cause very similar phenotypes. We have previously shown that the USH1G protein SANS (scaffold protein containing ankyrin repeats and SAM domain) contributes to the periciliary protein network in retinal photoreceptor cells. This study aimed to further elucidate the role of SANS by identifying novel interaction partners. In yeast two-hybrid screens of retinal cDNA libraries we identified 30 novel putative interacting proteins binding to the central domain of SANS (CENT). We confirmed the direct binding of the phosphodiesterase 4D interacting protein (PDE4DIP), a Golgi associated protein synonymously named myomegalin, to the CENT domain of SANS by independent assays. Correlative immunohistochemical and electron microscopic analyses showed a co-localization of SANS and myomegalin in mammalian photoreceptor cells in close association with microtubules. Based on the present results we propose a role of the SANS-myomegalin complex in microtubule-dependent inner segment cargo transport towards the ciliary base of photoreceptor cells. Copyright © 2011 Elsevier B.V. All rights reserved.

33 CFR 165.1121 - Security Zone: Fleet Supply Center Industrial Pier, San Diego, CA.

Science.gov (United States)

2010-07-01

... Guard District § 165.1121 Security Zone: Fleet Supply Center Industrial Pier, San Diego, CA. (a... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone: Fleet Supply Center Industrial Pier, San Diego, CA. 165.1121 Section 165.1121 Navigation and Navigable Waters COAST...

76 FR 4371 - Notice of Intent to Prepare an Environmental Impact Statement for the Proposed San Juan Basin...

Science.gov (United States)

2011-01-25

...; NMNM122352] Notice of Intent to Prepare an Environmental Impact Statement for the Proposed San Juan Basin Energy Connect Project, San Juan County, New Mexico, and La Plata County, Colorado AGENCY: Bureau of Land... prepare an Environmental Impact Statement (EIS) on the proposed San Juan Energy Connect Project, and by...

78 FR 73557 - Guadalupe-Nipomo Dunes National Wildlife Refuge, San Luis Obispo County, CA: Intent To Prepare a...

Science.gov (United States)

2013-12-06

...-FF08R00000] Guadalupe-Nipomo Dunes National Wildlife Refuge, San Luis Obispo County, CA: Intent To Prepare a...) for the Guadalupe-Nipomo Dunes National Wildlife Refuge located in San Luis Obispo County of... (Refuge) in San Luis Obispo County, California. This notice complies with our CCP policy to (1) advise...

San Sebastiani festivali varjutasid hiljutised terroriaktid / Aare Ermel

Index Scriptorium Estoniae

Ermel, Aare, 1957-2013

2001-01-01

San Sebastiani rahvusvahelisel filmifestivalil sai Suure Kuldse merikarbi tšiillase Orlando Lubberti film "Takso kolmele". Parima režissööri auhinna pälvis Jean-Pierre Ameris realistliku draamaga "C'est la vie". Ka teistest auhinnatutest

Cultural conflicts, dilemmas and disillusionment among the San communities at Platfontein

Directory of Open Access Journals (Sweden)

G.T. Batha

2014-12-01

Full Text Available This article examines the cultural conflicts, dilemmas and disillusionment among the San communities at Platfontein in the Northern Cape province of South Africa. A critical review of written texts, interviews, observations and focus group discussions with the community knowledge-holders shows that the community’s new Westernised lifestyle in the midst of the capitalist society at Platfontein turns the collective spirit, human relations, mutual reverence, sincerity and self-confidence that existed before their contact with Westernised societies into unusual selfishness, individualism, impiety, dishonesty, greed and disregard for others. The conflict between the communal hunter-gatherer culture and the alien individualist mode of existence has created serious dilemmas and moral conflicts in the community. The Westernised mode of existence has alienated the community from their human nature, their natural environment, their productive chores and their communal life. The community has an undefined, unclear and controversial understanding of their own racial identity. The San refer to the black and white races that have historical relationships with them as Others, which in turn has an Othering effect on the San themselves. The causes of moral and psychological conflicts, identity crises, dilemmas and disillusionment are power relations related to ethnic and racial politics, colonial discourse and identity politics. The researcher recommends that to achieve harmonious relationships with other communities and among themselves, the San need to redefine themselves and other societies that have historical ties with them.

Geología y aspectos geográficos de la isla de san andrés, colombia

OpenAIRE

Vargas Cuervo, German

2012-01-01

La Isla de San Andrés ha sido definida geológicamente por varios autores en dos unidades calcáreas de características bien marcadas: Una unidad de calizas heterogéneas,denominada como Formación San Andrés de edad Mioceno y una unidad de calizas coralinas de edad Pleistoceno, conocida como Formación San Luis. La primera unidad aflora en la parte central de la isla y representa la zona de colinas suaves con alturas máximas de 87 m.s.n.m y la Formación San Luis constituye la región plana a suave...

Conformation and activity alteration of horseradish peroxidase induced by the interaction with gene carrier polyethyleneimines

Science.gov (United States)

Huang, Aimin; Wei, Bangzhi; Mo, Junyong; Wang, Yajing; Ma, Lin

2018-01-01

Polyethyleneimine (PEI) has long been considered as "golden standard" for polymeric gene delivery carriers. However the molecular basis of the cytotoxicity of PEI is poorly understood. Little is known about the effects of PEI on the structure and functions of biomacromolecules. In this work, fluorescence, UV-vis absorption, circular dichroism spectroscopy were conducted to investigate the influence of PEI of average molecular weight 25, 10 and 1.8 kDa (denoted as PEI25k, PEI10k and PEI1.8k) on the conformation of horseradish peroxidase (HRP) and its catalytic efficiency. Zeta-potential measurement and isothermal titration calorimetry were used to reveal the mechanism of the interaction between PEIs and HRP. PEIs were found to bind onto the surface of HRP predominantly via hydrophobic interaction and hydrogen bond or van der Waals interaction. The complex formation between HRP and PEI induced a more compact conformation of the enzyme and an increased hydrophobicity of the microenvironment surrounding heme pocket. The conformational change of HRP had little impact on the affinity towards H2O2 and phenol. However, the increase in the non-planarity of porphyrin ring in the heme group led to an increase in the exposure degree of the active center and thus an enhancement of catalytic efficiency of HRP in the presence of high molecular weight PEIs (PEI25k and PEI10k). The polymer size played an important role in PEI-HRP interaction. PEI of low molecular weight (PEI1.8k) was less efficient to alter the conformation and catalytic activity of HRP in aqueous solutions.

User-friendly software for SANS data reduction and analysis

International Nuclear Information System (INIS)

Biemann, P.; Haese-Seiller, M.; Staron, P.

1999-01-01

At the Geesthacht Neutron Facility (GeNF) a new software is being developed for the reduction of two-dimensional small-angle neutron scattering (SANS) data. The main motivation for this work was to created software for users of our SANS facilities that is easy to use. Another motivation was to provide users with software they can also use at their home institute. Therefore, the software is implemented on a personal computer running WINDOWS. The program reads raw data from an area detector in binary or ascii format and produces ascii files containing the scattering curve. The cross section can be averaged over the whole area of the detector or over users defined sectors only. Scripts can be created for processing large numbers of files. (author)

Descenso de las propiedades mecánicas del pei reforzado con fibra de vidrio y carbono en ambientes químicos

Directory of Open Access Journals (Sweden)

Viña, J.

2000-08-01

Full Text Available This work shows how the mechanical properties, tensile and shear strength, are modified in different way if two different types of composite materials are immersed in toluen and sulfuric acid. The composites have a thermoplastic as matrix and one of them is reinforced with glass fiber and the other with carbon fiber. Also the important influence of the temperature has been tested in the case of the acid and specimens with holes have been tested to know their influence.

El presente trabajo muestra la diferente influencia que sobre las propiedades mecánicas, resistencias a tracción y cortadura, tiene la inmersión en dos agentes químicos, tales como, tolueno y ácido sulfúrico de dos tipos diferentes de materiales compuestos, uno reforzado con fibra de vidrio y otro con fibra de carbono. En ambos casos la matriz empleada es un termoplástico de altas prestaciones denominado PEI. En el caso del ataque con el ácido se ha podido, asimismo, contrastar la importante influencia de la temperatura en la disminución de las resistencias y por último, también se han ensayado, a tracción, probetas que contenían agujeros pasantes para, en este caso, descartar que el aumento de la superficie de ataque aumentaba éste.

Distribution and abundance of Least Bell’s Vireos (Vireo bellii pusillus) and Southwestern Willow Flycatchers (Empidonax traillii extimus) on the Middle San Luis Rey River, San Diego County, southern California—2017 data summary

Science.gov (United States)

Allen, Lisa D.; Howell, Scarlett L.; Kus, Barbara E.

2018-04-20

We surveyed for Least Bell’s Vireos (LBVI) (Vireo bellii pusillus) and Southwestern Willow Flycatchers (SWFL) (Empidonax traillii extimus) along the San Luis Rey River, between College Boulevard in Oceanside and Interstate 15 in Fallbrook, California (middle San Luis Rey River), in 2017. Surveys were conducted from April 13 to July 11 (LBVI) and from May 16 to July 28 (SWFL). We found 146 LBVI territories, at least 107 of which were occupied by pairs. Five additional transient LBVIs were detected. LBVIs used five different habitat types in the survey area: mixed willow, willow-cottonwood, willow-sycamore, riparian scrub, and upland scrub. Forty-four percent of the LBVIs occurred in habitat characterized as mixed willow and 89 percent of the LBVI territories occurred in areas with greater than 50 percent native plant cover. Of 16 banded LBVIs detected in the survey area, 8 had been given full color-band combinations prior to 2017. Four other LBVIs with single (natal) federal bands were recaptured and banded in 2017. Three LBVIs with single dark blue federal bands indicating that they were banded as nestlings on the lower San Luis Rey River and one LBVI with a single gold federal band indicating that it was banded as a nestling on Marine Corps Base Camp Pendleton (MCBCP) could not be recaptured for identification. One banded LBVI emigrated from the middle San Luis Rey River to the lower San Luis Rey River in 2017.One resident SWFL territory and one transient Willow Flycatcher of unknown subspecies (WIFL) were observed in the survey area in 2017. The resident SWFL territory, which was comprised of mixed willow habitat (5–50 percent native plant cover), was occupied by a single male from May 22 to June 21, 2017. No evidence of pairing or nesting activity was observed. The SWFL male was banded with a full color-combination indicating that he was originally banded as a nestling on the middle San Luis Rey River in 2014 and successfully bred in the survey area in 2016

El patrimonio identitario de la comunidad de San Andrés

Directory of Open Access Journals (Sweden)

Carlos Córdova Martínez

2006-01-01

Full Text Available La identidad y el patrimonio son elementos recurrentes si se quiere defender la cultura frente a un mundo globalizado. Dicha labor debe realizarse de lo local a lo nacional y viceversa. El trabajo aborda el patrimonio de una pequeña comunidad holguinera, el Consejo Popular de San Andrés, cuyo centro es el poblado homónimo. Con un largo devenir histórico, que se remonta a fines del siglo XVI. San Andrés atesora un rico patrimonio, que puede incluirse fundamentalmente dentro de la cultura campesina.

Virgen de la Misericordia, San Jerónimo y San Miguel: el origen del corporativismo sedero en la Valencia bajomedieval (1465-1518.

Directory of Open Access Journals (Sweden)

Juan Martínez Vinat

2017-06-01

Full Text Available El presente estudio indaga sobre el origen del asociacionismo sedero valenciano a través de las tres principales corporaciones fundadas en Valencia a finales de la Edad Media: la cofradía de la Misericordia de veleros de seda, la cofradía de San Jerónimo del Art de Velluters y la cofradía de tintoreros de seda de San Miguel. El análisis de sus ordenanzas confraternales y gremiales, contrastado con otras fuentes documentales de tipo contable (Llibres de Dates e Rebudes, nos permiten conocer la realidad, funcionamiento y desarrollo de tres entidades que protagonizaron el arranque de la sedería valenciana, tanto desde la perspectiva laboral como desde la óptica benéfico-asistencial, ambas inseparables en el periodo que nos ocupa.

Vegetation Mapping - Tecolote Canyon, San Diego Co. [ds656

Data.gov (United States)

California Natural Resource Agency — Vegetation mapping has been conducted at various City of San Diego Park and Recreation Open Space lands in support of natural resource management objectives and the...

Baseline Surveys - Tecolote Canyon, San Diego Co. [ds655

Data.gov (United States)

California Natural Resource Agency — Various resource projects have been conducted in the City of San Diego's Open Space Parks as part of the implementation of the City's Multiple Species Conservation...

San Francisco, California Tsunami Forecast Grids for MOST Model

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The San Francisco, California Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

Loading of the San Andreas fault by flood-induced rupture of faults beneath the Salton Sea

Science.gov (United States)

Brothers, Daniel; Kilb, Debi; Luttrell, Karen; Driscoll, Neal W.; Kent, Graham

2011-01-01

The southern San Andreas fault has not experienced a large earthquake for approximately 300 years, yet the previous five earthquakes occurred at ~180-year intervals. Large strike-slip faults are often segmented by lateral stepover zones. Movement on smaller faults within a stepover zone could perturb the main fault segments and potentially trigger a large earthquake. The southern San Andreas fault terminates in an extensional stepover zone beneath the Salton Sea—a lake that has experienced periodic flooding and desiccation since the late Holocene. Here we reconstruct the magnitude and timing of fault activity beneath the Salton Sea over several earthquake cycles. We observe coincident timing between flooding events, stepover fault displacement and ruptures on the San Andreas fault. Using Coulomb stress models, we show that the combined effect of lake loading, stepover fault movement and increased pore pressure could increase stress on the southern San Andreas fault to levels sufficient to induce failure. We conclude that rupture of the stepover faults, caused by periodic flooding of the palaeo-Salton Sea and by tectonic forcing, had the potential to trigger earthquake rupture on the southern San Andreas fault. Extensional stepover zones are highly susceptible to rapid stress loading and thus the Salton Sea may be a nucleation point for large ruptures on the southern San Andreas fault.

A basin-scale approach for assessing water resources in a semiarid environment: San Diego region, California and Mexico

Directory of Open Access Journals (Sweden)

L. E. Flint

2012-10-01

Full Text Available Many basins throughout the world have sparse hydrologic and geologic data, but have increasing demands for water and a commensurate need for integrated understanding of surface and groundwater resources. This paper demonstrates a methodology for using a distributed parameter water-balance model, gaged surface-water flow, and a reconnaissance-level groundwater flow model to develop a first-order water balance. Flow amounts are rounded to the nearest 5 million cubic meters per year.

The San Diego River basin is 1 of 5 major drainage basins that drain to the San Diego coastal plain, the source of public water supply for the San Diego area. The distributed parameter water-balance model (Basin Characterization Model was run at a monthly timestep for 1940–2009 to determine a median annual total water inflow of 120 million cubic meters per year for the San Diego region. The model was also run specifically for the San Diego River basin for 1982–2009 to provide constraints to model calibration and to evaluate the proportion of inflow that becomes groundwater discharge, resulting in a median annual total water inflow of 50 million cubic meters per year. On the basis of flow records for the San Diego River at Fashion Valley (US Geological Survey gaging station 11023000, when corrected for upper basin reservoir storage and imported water, the total is 30 million cubic meters per year. The difference between these two flow quantities defines the annual groundwater outflow from the San Diego River basin at 20 million cubic meters per year. These three flow components constitute a first-order water budget estimate for the San Diego River basin. The ratio of surface-water outflow and groundwater outflow to total water inflow are 0.6 and 0.4, respectively. Using total water inflow determined using the Basin Characterization Model for the entire San Diego region and the 0.4 partitioning factor, groundwater outflow from the San Diego region, through

Recent research on the hydrodynamics of the Sacramento - San Joaquin River Delta and north San Francisco Bay

Science.gov (United States)

Burau, J.R.; Monismith, S.G.; Stacey, M.T.; Oltmann, R.N.; Lacy, J.R.; Schoellhamer, D.H.

1999-01-01

This article presents an overview of recent findings from hydrodynamic research on circulation and mixing in the Sacramento-San Joaquin Delta (Delta) (Figure 1) and North San Francisco Bay (North Bay) (Figure 2). For the purposes of this article, North Bay includes San Pablo Bay, Carquinez Strait, and Suisun Bay. The findings presented are those gained from field studies carried out by the U.S. Geological Survey (USGS), as part of the Interagency Ecological Program (IEP), and Stanford University beginning about 1993. The premise behind these studies was that a basic understanding of circulation and mixing patterns in the Bay and Delta is an essential part of understanding how biota and water quality are affected by natural hydrologic variability, water appropriation, and development activities. Data collected for the field studies described in this article have significantly improved our understanding of Bay and Delta hydrodynamics. Measured flows ,in the Delta have provided valuable information on how water moves through the Delta's network of channels and how export pumping affects flows. Studies of the shallows and shallow-channel exchange processes conducted in Honker Bay have shown that the water residence time in Honker Bay is much shorter than previously reported (on the order of hours to several tidal cycles instead ofweeks). Suisun Bay studies have provided data on hydrodynamic transport and accumulation mechanisms that operate primarily in the channels. The Suisun Bay studies have caused us to revise our understanding of residual circulation in the channels of North Bay and of "entrapment" mechanisms in the low salinity zone. Finally, detailed tidal and residual (tidally averaged) time-scale studies of the mechanisms that control gravitational circulation in the estuary show that density-driven transport in the channels is governed by turbulence time-scale (seconds) interactions between the mean flow and stratification. The hydrodynamic research

Aerial radiological survey of the San Onofre Nuclear Generating Station and surrounding area, San Clemente, California

International Nuclear Information System (INIS)

Hilton, L.K.

1980-12-01

An airborne radiological survey of an 11 km 2 area surrounding the San Onofre Nuclear Generating Station was made 9 to 17 January 1980. Count rates observed at 60 m altitude were converted to exposure rates at 1 m above the ground and are presented in the form of an isopleth map. Detected radioisotopes and their associated gamma ray exposure rates were consistent with that expected from normal background emitters, except directly over the plant

Yi-Gan San Restores Behavioral Alterations and a Decrease of Brain Glutathione Level in a Mouse Model of Schizophrenia

Directory of Open Access Journals (Sweden)

Manabu Makinodan M.D.

2009-01-01

Full Text Available The traditional Chinese herbal medicine yi-gan san has been used to cure neuropsychological disorders. Schizophrenia can be one of the target diseases of yi-gan san. We aimed at evaluating the possible use of yi-gan san in improving the schizophrenic symptoms of an animal model. Yi-gan san or distilled water was administered to mice born from pregnant mice injected with polyinosinic-polycytidilic acid or phosphate buffered saline. The former is a model of schizophrenia based on the epidemiological data that maternal infection leads to psychotic disorders including schizophrenia in the offspring. Prepulse inhibition and sensitivity to methamphetamine in open field tests were analyzed and the total glutathione content of whole brains was measured. Yi-gan san reversed the decrease in prepulse inhibition, hypersensitivity to methamphetamine and cognitive deficits found in the model mice to the level of control mice. Total glutathione content in whole brains was reduced in the model mice but was restored to normal levels by yi-gan san treatment. These results suggest that yi-gan san may have ameliorating effects on the pathological symptoms of schizophrenia.

The comparative study of CT guided and ultrasound guided percutaneous ethanol injection in the treatment of intra-abdominal cyst

International Nuclear Information System (INIS)

Li Heping; Yang Jianyong; Chen Wei; Zhuang Wenquan; Huang Yulian; Chen Jianye

2005-01-01

Objective: An comparative study of the interventional approach of CT guided and ultiasound guided percutaneous ethanol injection(PEI) in the treatment of intra-abdominal cyst. Methods: CT guided PEI was performed in the treatment of intra-abdominal cyst in 38 patients while ultrasound guided PEI was performed in 45 cases. Results: The puncture procedure of CT guided PEI was totally performed 83 times in treating 56 intra-abdominal cysts in 38 patients and CT guided PEI was unsuccessful in 6 patients. The puncture procedure of ultrasound guided PEI were performed 87 times in treating 71 intra-abdominal cysts in 55 patients and ultrasound guided PEI only failed only in 1 patient. Conclusion: Ultrasound guided PEI is superior to CT guided PEI in the treatment of intra-abdominal cyst. (authors)

San Francisco Bay Interferometric Side Scan Imagery: Area A

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Backscatter imagery data were collected over shallow subtidal areas in the San Francisco Bay estuary system. Bathymetric and acoustic backscatter data were collected...

Protección contra inundaciones en zonas urbanas: Caso de la urbanización San Diego distrito de San Martín de Porres-Lima

OpenAIRE

Orosco Benites, Juan Carlos Felipe; Orosco Benites, Juan Carlos Felipe

2004-01-01

El presente trabajo de investigación, trate de explicar en forma didáctica los conocimientos necesarios para poder hacer un análisis y diseño de una protección contra inundaciones en zonas urbanas. En este caso se tomará como ejemplo la urbanización San Diego, en el distrito de San Martín de Porres, el cual periódicamente sufre graves peligros en los meses de enero a marzo por las crecidas del río Chillón. Por tal motivo, se buscó darle una solución técnica a este problema, por...

United States Air Force Personalized Medicine and Advanced Diagnostics Program Panel: Representative Research at the San Antonio Military Medical Center

Science.gov (United States)

2016-05-20

health system. dedicated to excellence in global care PROCESSING OF PROFESSIONAL MEDICAL RESEARCH PUBLICATIONS/PRESENTATIONS INSTRUCTIONS 1. The...present this research at the University of Texas at San Antonio/SAMHS & Universities Research Forum, SURF 2016 in San Antonio, TX, on 20 May 2016. The...at San Antonio/SAMHS & Universities Research Forum, SURF 2016 in San Antonio, TX, on 20 May 2016. 3. LAWS AND REGULATIONS: DoD 5500.07-R, Joint

San Jacinto River oil spill: wetland bioremediation project

International Nuclear Information System (INIS)

Mills, M.A.; Bonner, J.S.

1996-01-01

Gasoline, diesel and unrefined Arabian light crude oil were accidentally released into the San Jacinto River after a series of pipelines ruptured. Natural removal processes (volatilization, dissolution, weathering), fire, and the spill clean-up effort, removed approximately 95% of the petroleum. The area where residual oil was found was an estuarine wetland on the lower San Jacinto River. Samples were collected from 21 study areas and an evaluation of the varying levels of bioremediation was conducted. Phase one has been completed and involved the evaluation of the natural recovery of oil from the spill. Phase two was still in progress and involved the addition of inorganic nutrients and the alternate electron acceptor to enhance the biodegradation of the petroleum. Results showed that biodegradation was responsible for much of the reduction of certain components in petroleum within the first 150 days. 12 refs., 8 figs

San José - El Barrial (Valle Calchaquí, Salta: enfoque biodemográfico

Directory of Open Access Journals (Sweden)

Albeza, María V.

2003-01-01

Full Text Available San José y El Barrial (Departamento de Cachi, Salta pertenecen a la extensa área de los Valles Calchaquíes de la región NOA. Pese a estar separadas por una distancia de 500 metros, sus pobladores se identifican taxativamente en una de ellas. Se realizó una aproximación demográfico-genética a fin de evaluar el accionar de factores evolutivos direccionales (selección natural y flujo génico y estocásticos (deriva génica además de una descripción de la estructura poblacional de dichas localidades. Se entrevistó a la totalidad de los individuos que se encontraban presentes en el momento de la recolección de los datos. San José (N = 154 es una población joven, en tanto que en El Barrial (N = 66 la población mayor de 65 años (14.52 % supera ampliamente el valor estándar de las Naciones Unidas. Estos valores coinciden con la baja Relación Niños-Mujeres y escaso número de individuos entre 0-4 años registrados en El Barrial en contraposición con San José. Ambas poblaciones presentan una alta probabilidad de fijación por deriva medida a través del Coeficiento de Aislamiento Reproductivo y el de Endogamia. La tasa de migración efectiva es menor en San José (0.12 que en El Barrial (0.34. El mayor Indice de Oportunidad para la Selección fue registrado en El Barrial (I = 0.58. If / ps es 0.081 para San José y 0.389 para El Barrial, representando el 32.4 % y el 67.07 % respectivamente por lo que en San José la mayor oportunidad para la selección se estaría ejerciendo a través de la componente de mortalidad y en El Barrial de la de fecundidad.

Geomorphic and geologic evidence for slip along the San Bernardino strand of the San Andreas Fault System through the San Gorgonio Pass structural knot, southern California

Science.gov (United States)

Kendrick, K. J.; Matti, J. C.

2017-12-01

The San Gorgonio Pass (SGP) region of southern California represents an extraordinarily complex section of the San Andreas Fault (SAF) zone, often referred to as a structural knot. Complexity is expressed both structurally and geomorphically, and arises because multiple strands of the SAF have evolved here in Quaternary time. Our integration of geologic and geomorphic analyses led to recognition of multiple fault-bounded blocks characterized by crystalline rocks that have similar physical properties. Hence, any morphometric differences in hypsometric analysis, slope, slope distribution, texture, and stream-power measurements and discontinuities reflect landscape response to tectonic processes rather than differences in lithology. We propose that the differing morphometry of the two blocks on either side of the San Bernardino strand (SBS) of the SAF, the high-standing Kitching Peak block to the east and the lower, more subdued Pisgah Peak block to the west, strongly suggests that the blocks experienced different uplift histories. This difference in uplift histories, in turn suggests that dextral slip occurred over a long time interval on the SBS—despite long-lived controversy raised by the fact that, at the surface, a throughgoing trace of the SBS is not present at this location. A different tectonic history between the two blocks is consistent with the gravity data which indicate that low-density rocks underthrusting the Kitching Peak block are absent below the Pisgah Peak block (Langenheim et al., 2015). Throughgoing slip on the SBS implied by geomorphic differences between the two blocks is also consistent with displaced geologic and geomorphic features. We find compelling evidence for discrete offsets of between 0.6 and 6 km of dextral slip on the SBS, including offset of fluvial and landslide deposits, and beheaded drainages. Although we lack numerical age control for the offset features, the degree of soil development associated with displaced landforms

Coulomb Stress Accumulation along the San Andreas Fault System

Science.gov (United States)

Smith, Bridget; Sandwell, David

2003-01-01

Stress accumulation rates along the primary segments of the San Andreas Fault system are computed using a three-dimensional (3-D) elastic half-space model with realistic fault geometry. The model is developed in the Fourier domain by solving for the response of an elastic half-space due to a point vector body force and analytically integrating the force from a locking depth to infinite depth. This approach is then applied to the San Andreas Fault system using published slip rates along 18 major fault strands of the fault zone. GPS-derived horizontal velocity measurements spanning the entire 1700 x 200 km region are then used to solve for apparent locking depth along each primary fault segment. This simple model fits remarkably well (2.43 mm/yr RMS misfit), although some discrepancies occur in the Eastern California Shear Zone. The model also predicts vertical uplift and subsidence rates that are in agreement with independent geologic and geodetic estimates. In addition, shear and normal stresses along the major fault strands are used to compute Coulomb stress accumulation rate. As a result, we find earthquake recurrence intervals along the San Andreas Fault system to be inversely proportional to Coulomb stress accumulation rate, in agreement with typical coseismic stress drops of 1 - 10 MPa. This 3-D deformation model can ultimately be extended to include both time-dependent forcing and viscoelastic response.

San Fernando: ¿utopía o proyecto inconcluso?

Directory of Open Access Journals (Sweden)

Juan Pablo Murillo

2008-06-01

Full Text Available El estudio analiza los distintos proyectos de modernización ocurridos en la Facultad de Medicina de San Fernando, en el contexto de una seria crisis institucional a finales del siglo XX. Para ello, a partir de las categorías de colectivo de pensamiento y estilo de pensamiento propuestos por Ludwick Fleck, se hace un estudio de los procesos socio-históricos relacionados con los distintas iniciativas desplegadas en la más antigua escuela de medicina del Perú. Un análisis de las diferentes iniciativas identificadas nos llevan a la hipótesis de que la crisis de San Fernando, como colectivo académico, se basa en las contradicciones propias de un proyecto institucional inconcluso, que además cíclicamente se manifiesta asincrónico y disfuncional, al complejo y cambiante entorno institucional y cultural de la sociedad peruana. El estudio sistematiza las principales características de los diferentes proyectos de modernización institucional. Luego de un análisis del actual contexto del sector salud peruano, a partir de los procesos identificados, se propone una agenda de desarrollo, orientada a generar un ciclo de acumulación y crecimiento académico, que constituya una etapa de transición de cara a los retos que el siglo XXI plantea a los miembros del colectivo San Fernandino.

Examining Dimethyl Sulfide Emissions in California's San Joaquin Valley

Science.gov (United States)

Huber, D.; Hughes, S.; Blake, D. R.

2017-12-01

Dimethyl Sulfide (DMS) is a sulfur-containing compound that leads to the formation of aerosols which can lead to the formation of haze and fog. Whole air samples were collected on board the NASA C-23 Sherpa aircraft during the 2017 Student Airborne Research Program (SARP) over dairies and agricultural fields in the San Joaquin Valley. Analysis of the samples indicate average DMS concentrations of 23 ± 9 pptv, with a maximum concentration of 49 pptv. When compared with DMS concentrations from previous SARP missions (2009-2016), 2017 by far had the highest frequency of elevated DMS in this region. For this study, agricultural productivity of this region was analyzed to determine whether land use could be contributing to the elevated DMS. Top down and bottom up analysis of agriculture and dairies were used to determine emission rates of DMS in the San Joaquin Valley. Correlations to methane and ethanol were used to determine that DMS emissions were strongly linked to dairies, and resulted in R2 values of 0.61 and 0.43, respectively. These values indicate a strong correlation between dairies and DMS emissions. Combined with NOAA HySPLIT back trajectory data and analysis of ground air samples, results suggest that the contribution of dairies to annual DMS emissions in the San Joaquin Valley exceeds those from corn and alfalfa production.

Una lucha a "cielo abierto" : el caso del Frente Amplio Opositor a Minera San Xavier

OpenAIRE

Lamberti, María Julieta

2010-01-01

Se presenta un estudio de caso de un conflicto ecológico distributivo por la instalación de una empresa minera de tajo a cielo abierto desde la perspectiva de uno de los actores involucrados, el Frente Amplio Opositor a Minera San Xavier en Cerro de San Pedro, San Luis Potosí. Para dar cuenta del sentido que le otorgan los miembros del FAO a la instalación de la empresa en la comunidad se utilizan los procesos de enmarcado como herramienta de interpretación. I. La interpretación de los con...

Illegal drug use and its correlates in San Juan, Puerto Rico.

Science.gov (United States)

Caetano, Raul; Vaeth, Patrice A C; Canino, Glorisa

2018-04-01

Data on the prevalence and correlates of illegal drug use in Puerto Rico are now almost 20 years old. This study sought to estimate the 12-month prevalence of illegal and non-prescribed medical drug use in San Juan, Puerto Rico and identify sociodemographic correlates of use. Data are from a random household sample of 1510 individuals, 18-64 years of age in San Juan, Puerto Rico. The 12-month prevalence of any illegal or non-prescribed drug use was 16.5%. Prevalence among men (20.7%) was higher than among women (12.9%; chi 2  = 16.308; df = 1; p  .05) were negatively associated with drug use compared to annual income up to $10,000. As in many other places in the U.S., drug use in San Juan, Puerto Rico is high, affecting about 1 in 6 adults in the population. The highest prevalence is for marijuana use, which cannot be medically prescribed and of which recreational use is illegal on the island. Copyright © 2018 Elsevier B.V. All rights reserved.

for presence of hookworms (Uncinaria spp. on San Miguel Island, California

Directory of Open Access Journals (Sweden)

Lyons E. T.

2016-06-01

Full Text Available Necropsy and extensive parasitological examination of dead northern elephant seal (NES pups was done on San Miguel Island, California, in February, 2015. The main interest in the current study was to determine if hookworms were present in NESs on San Miguel Island where two hookworm species of the genus Uncinaria are known to be present - Uncinaria lyonsi in California sea lions and Uncinaria lucasi in northern fur seals. Hookworms were not detected in any of the NESs examined: stomachs or intestines of 16 pups, blubber of 13 pups and blubber of one bull. The results obtained in the present study of NESs on San Miguel Island plus similar finding on Año Nuevo State Reserve and The Marine Mammal Center provide strong indication that NES are not appropriate hosts for Uncinaria spp. Hookworm free-living third stage larvae, developed from eggs of California sea lions and northern fur seals, were recovered from sand. It seems that at this time, further search for hookworms in NESs would be nonproductive.

Turbulent Flame Stabilization Methods Using Confinement, Diluents, and High-Potential Electric Fields

Science.gov (United States)

2014-08-03

Kevin Lyons Alexei Saveliev Committee Chair ________________________________ ________________________________ Tiegang Fang...Lyons, for his guidance and support -Dr. Alexei Saveliev , Dr. Tiegang Fang, and Dr. Stephen Terry for serving on my committee -Dr. Glenn Walker

Auckland--New Zealand's Los Angeles or San Francisco?

Science.gov (United States)

Bogunovich, Dushko

1995-01-01

Compares Auckland (New Zealand) with San Francisco (California) in terms of topographical structure, geographic location, and urban development. Both cities contain striking similarities. Maintains that Auckland can become a world-class city renowned for its beauty if developers and government work in tandem. (MJP)

Waste reduction algorithm used as the case study of simulated bitumen production process

Directory of Open Access Journals (Sweden)

Savić Marina A.

2011-01-01

Full Text Available Waste reduction algorithm - WAR is a tool helping process engineers for environmental impact assessment. WAR algorithm is a methodology for determining the potential environmental impact (PEI of a chemical process. In particular, the bitumen production process was analyzed following three stages: a atmospheric distillation unit, b vacuum distillation unit, and c bitumen production unit. Study was developed for the middle sized oil refinery with capacity of 5000000 tones of crude oil per year. Results highlight the most vulnerable aspects of the environmental pollution that arise during the manufacturing process of bitumen. The overall rates of PEI leaving the system (PEI/h - Iout PEI/h are: a 2.14105, b 7.17104 and c 2.36103, respectively. The overall rates of PEI generated within the system - Igen PEI/h are: a 7.75104, b -4.31104 and c -4.32102, respectively. Atmospheric distillation unit have the highest overall rate of PEI while the bitumen production unit have the lowest overall rate of PEI. Comparison of Iout PEI/h and Igen PEI/h values for the atmospheric distillation unit, shows that the overall rate of PEI generated in the system is 36.21% of the overall rate of PEI leaving the system. In the cases of vacuum distillation and bitumen production units, the overall rate of PEI generated in system have negative values, i.e. the overall rate of PEI leaving the system is reduced at 60.11% (in the vacuum distillation unit and at 18.30% (in the bitumen production unit. Analysis of the obtained results for the overall rate of PEI, expressed by weight of the product, confirms conclusions.

Mining geologic study in black san stones in Aguas Dulces, Rocha Province

International Nuclear Information System (INIS)

2002-01-01

On September of the 2002 black san stones deposit were considered Uruguay mining reservation which it last 6 months. They were selected the best deposits areas which were carried out 37 drillings in 727.046 hectare as. The mineralogical composition and uses of Black san stones sampling were analyzed.. Field and laboratory studies were given as methodology. As conclusion they were found 933.000 tons of mineral like ilmenite, zircon, rut ilo, monazite and titanite equivalent to 65% all heavy metals.

“Y SAN LUIS OBEDIENTE RESPONDÍA” LOS TERRATENIENTES DE LA CIUDAD DE SAN LUIS Y EL PLAN SANMARTINIANO (1814 - 1829

Directory of Open Access Journals (Sweden)

Melody Celeste Vera

2015-12-01

Full Text Available La base fundamental de la identidad de los habitantes de la provincia de San Luis (Argentina y de su historiografía, es el axioma que el pueblo puntano se inmoló por el proyecto sanmartiniano. El Gobernador Intendente Vicente Dupuy (1814-1820 fue el principal colaborador de José de San Martin en la provincia, y el coordinador de las donaciones de bienes y vidas para la causa. Contaba con el apoyo del “cabildo sanmartiniano”, un grupo de vecinos que secundaban sus ideales, apoyaban sus iniciativas y colaboraban materialmente. Pero luego de la caída del gobierno central en 1820 no se ofrece una interpretación sobre el cambio de proyecto político que representó el nuevo Gobernador, José Santos Ortiz (1820-1829. Si se consideran conjuntamente las oposiciones de un grupo de vecinos levantadas durante el gobierno de Dupuy y el accionar de Santos Ortiz durante su mandato, cabe preguntarse: ¿los cabildantes terratenientes apoyaron la gesta sanmartiniana por convicción, o se vieron forzados a hacerlo por la imposición de un grupo en el poder? ¿Representó Santos Ortiz el proyecto de lo que el grupo terrateniente buscaba y no pudo obtener mientras se llevaba delante el plan sanmartiniano? En este trabajo se busca comparar los objetivos primarios de ambos gobernadores durante sus mandatos, con el fin de vislumbrar cuál de los planes de gobierno representaba los ideales y necesidades de los grandes terratenientes de la ciudad de San Luis.

Biological and associated water-quality data for lower Olmos Creek and upper San Antonio River, San Antonio, Texas, April - September 1989

Science.gov (United States)

Taylor, R. Lynn; Ferreira, Rodger F.

1995-01-01

Biological and associated water-quality data were collected from lower Olmos Creek and upper San Antonio River in San Antonio, Texas, during April-September 1989. Benthic macroinvertebrate, periphyton, and phytoplankton communities were sampled at three sites along the Olmos Creek/San Antonio River system. Total mean densities of benthic macroinvertebrates for the three sites ranged from 670 to 10,000 organisms per square meter. The most abundant macroinvertebrates were the class Insecta (insects). Total densities of periphyton ranged from 2,900 to 110,000 cells per square millimeter. Cyanophyta (blue-green algae) and Bacillariophyta (diatoms) were the predominant periphyton organisms. Total densities of phyto- plankton ranged from 5,000 to 47,000 cells per square milliliter. Blue-green algae accounted for more than one- half of the phytoplankton in each sample. Hardness ranged from 160 to 250 milligrams per liter as calcium carbonate, and alkalinity ranged from 130 to 220 milligrams per liter as calcium carbonate. The largest dissolved nitrite concentration was 0.038 milligram per liter. The largest total phosphorus concentration was 0.150 milligram per liter, over one-half of which was dissolved orthophosphate. Total aluminum and total iron were the only trace elements in water to exceed the reporting threshold by large concen- trations. Total aluminum concentrations ranged from 70 to 280 micrograms per liter, and total iron concentrations ranged from 70 to 340 micrograms per liter. Lead was the most prominent trace element in bottom-material samples, with concentrations ranging from 30 to 230 micrograms per gram.

Coastal processes study at Ocean Beach, San Francisco, CA: summary of data collection 2004-2006

Science.gov (United States)

Barnard, Patrick L.; Eshleman, Jodi; Erikson, Li H.; Hanes, Daniel M.

2007-01-01

Ocean Beach in San Francisco, California, contains a persistent erosional section in the shadow of the San Francisco ebb tidal delta and south of Sloat Boulevard that threatens valuable public infrastructure as well as the safe recreational use of the beach. Coastal managers have been discussing potential mediation measures for over a decade, with little scientific research available to aid in decision making. The United States Geological Survey (USGS) initiated the Ocean Beach Coastal Processes Study in April 2004 to provide the scientific knowledge necessary for coastal managers to make informed management decisions. This study integrates a wide range of field data collection and numerical modeling techniques to document nearshore sediment transport processes at the mouth of San Francisco Bay, with emphasis on how these processes relate to erosion at Ocean Beach. The Ocean Beach Coastal Processes Study is the first comprehensive study of coastal processes at the mouth of San Francisco Bay.

LaRC Modeling of Ozone Formation in San Antonio, Texas

Science.gov (United States)

Guo, F.; Griffin, R. J.; Bui, A.; Schulze, B.; Wallace, H. W., IV; Flynn, J. H., III; Erickson, M.; Kotsakis, A.; Alvarez, S. L.; Usenko, S.; Sheesley, R. J.; Yoon, S.

2017-12-01

Ozone (O3) is one of the most important trace species within the troposphere and results from photochemistry involving emissions from a complex array of sources. Ground-level O3 is detrimental to ecosystems and causes a variety of human health problems including respiratory irritation, asthma and reduction in lung capacity. However, the O3 Design Value in San Antonio, Texas, was in violation of the federal threshold set by the EPA (70 ppb, 8-hr max) based on the average for the most recent three-year period (2014-2016). To understand the sources of high O3 concentrations in this nonattainment area, we assembled and deployed a mobile air quality laboratory and operated it in two locations in the southeast (Traveler's World RV Park) and northwest (University of Texas at San Antonio) of downtown San Antonio during summer 2017 to measure O3 and its precursors, including total nitrogen oxides (NOx) and volatile organic compounds (VOCs). Additional measurements included temperature, relative humidity, pressure, solar radiation, wind speed, wind direction, total reactive nitrogen (NOy), carbon monoxide (CO), and aerosol composition and concentration. We will use the campaign data and the NASA Langley Research Center (LaRC) Zero-Dimensional Box Model (Crawford et al., 1999; Olson et al., 2006) to calculate O3 production rate, NOx and hydroxyl radical chain length, and NOx versus VOCs sensitivity at different times of a day with different photochemical and meteorological conditions. A key to our understanding is to combine model results with measurements of precursor gases, particle chemistry and particle size to support the identification of O3 sources, its major formation pathways, and how the ozone production efficiency (OPE) depends on various factors. The resulting understanding of the causes of high O3 concentrations in the San Antonio area will provide insight into future air quality protection.

Simulation of SANS signal due to radiation damage in Fe

International Nuclear Information System (INIS)

Yu, G.; Schaublin, R.; Spatig, P.; Fikar, J.; Baluc, N.

2007-01-01

Full text of publication follows: A wide number of irradiation-induced defects in Fe-base materials (e.g. RAFM steels) have sizes in the range about 0.5 to 1 nm, which are expected to contribute to the irradiation-induced hardening and/or embrittlement phenomena. These defects are at the limit in spatial resolution of transmission electron microscopy (TEM), but they can be investigated using the small angle neutron scattering (SANS) technique, at least in terms of number density and size distribution. Determination of the type of defects (small dislocation loops, interstitials or vacancy clusters, precipitates and cavities, like voids or helium bubbles) is not straightforward. In order to analyze the type of nanometer-sized irradiation-induced defects in Fe-base materials Molecular Dynamics (MD) simulations of various distributions of different types irradiation-induced defects have been performed. The defects investigated consisted in dislocation loops with sizes of 0.5, 1.0 and 2.0 nm and 1/2 a 0 , 1/2 a 0 and a 0 Burgers vectors, cavities, like voids and helium bubbles, with sizes of 0.5, 1.0 and 2.0 nm, MD simulations of atomic displacement cascades were performed using MD samples with a size of 18 x 18 x 18 nm 3 at 10, 300 and 523 K, for PKA energies of 1, 3, 7 and 10 keV. Simulation of the corresponding nuclear SANS signal was performed using the Electron Microscopy Software (EMS) code that was originally designed to simulate TEM images and diffraction patterns and that was modified to simulate the SANS signal. Results of such simulations in pure Fe have been compared to experimental SANS measurements and TEM observations of irradiation-induced defects in Fe-base materials. (authors)

Late Quaternary evolution of the San Antonio Submarine Canyon in the central Chile forearc (∼33°S)

Science.gov (United States)

Laursen, Jane; Normark, William R.

2002-01-01

Hydrosweep swath-bathymetry and seismic-reflection data reveal the morphology, sedimentary processes, and structural controls on the submarine San Antonio Canyon. The canyon crosses the forearc slope of the central Chile margin for more than 150 km before it empties into the Chile Trench near 33°S latitude. In its upper reaches, the nearly orthogonal segments of the San Antonio Canyon incise ∼1 km into thick sediment following underlying margin-perpendicular basement faults and along the landward side of a prominent margin-parallel thrust ridge on the outer mid-slope. At a breach in the outer ridge, the canyon makes a sharp turn into the San Antonio Reentrant. Resistance to erosion of outcropping basement at the head of the reentrant has prevented the development of a uniformly sloping thalweg, leaving gentle gradients (6°) across the lower slope. Emergence of an obstruction across the head of the San Antonio Reentrant has trapped sediment in the mid-slope segments of the canyon. Presently, little sediment appears to reach the Chile Trench through the San Antonio Canyon. The development of the San Antonio Canyon was controlled by the impact of a subducted seamount, which formed the San Antonio Reentrant and warped the middle slope along its landward advancing path. Incision of the canyon landward of the outer mid-slope ridge may be ascribed to a combination of headward erosion and entrenchment by captured unconfined turbidity currents. Flushing of the canyon was likely enhanced during the lowered sea level of the last glaciation. Where the canyon occupies the triangular embayment of the reentrant at the base of the slope, sediment has ponded behind a small accretionary ridge. On the trench floor opposite the San Antonio Canyon mouth, a 200-m-thick levee–overbank complex formed on the left side of a distributary channel emanating from a breach in the accretionary ridge. Axial transfer of sediment was inhibited to the north of the San Antonio Canyon mouth

Does centennial morphodynamic evolution lead to higher channel efficiency in San Pablo Bay, California?

Science.gov (United States)

van der Wegen, M.; Jaffe, B.E.; Barnard, P.L.; Jaffee, B.E.; Schoellhamer, D.H.

2013-01-01

Measured bathymetries on 30 year interval over the past 150 years show that San Pablo Bay experienced periods of considerable deposition followed by periods of net erosion. However, the main channel in San Pablo Bay has continuously narrowed. The underlying mechanisms and consequences of this tidal channel evolution are not well understood. The central question of this study is whether tidal channels evolve towards a geometry that leads to more efficient hydraulic conveyance and sediment throughput. We applied a hydrodynamic process-based, numerical model (Delft3D), which was run on 5 San Pablo Bay bathymetries measured between 1856 and 1983. Model results shows increasing energy dissipation levels for lower water flows leading to an approximately 15% lower efficiency in 1983 compared to 1856. During the same period the relative seaward sediment throughput through the San Pablo Bay main channel increased by 10%. A probable explanation is that San Pablo Bay is still affected by the excessive historic sediment supply. Sea level rise and Delta surface water area variations over 150 years have limited effect on the model results. With expected lower sediment concentrations in the watershed and less impact of wind waves due to erosion of the shallow flats, it is possible that energy dissipations levels will decrease again in future decades. Our study suggests that the morphodynamic adaptation time scale to excessive variations in sediment supply to estuaries may be on the order of centuries.

Preparation and in vitro characterization of gallic acid-loaded human serum albumin nanoparticles

Science.gov (United States)

Mohammad-Beigi, Hossein; Shojaosadati, Seyed Abbas; Morshedi, Dina; Arpanaei, Ayyoob; Marvian, Amir Tayaranian

2015-04-01

Gallic acid (GA), as an antioxidant and antiparkinson agent, was loaded onto cationic human serum albumin nanoparticles (HSA NPs). Polyethylenimine (PEI)-coated HSA (PEI-HSA) NPs were prepared using three different methods: (I) coating negatively charged HSA NPs with positively charged PEI through attractive electrostatic interactions, (II) coating HSA NPs with PEI via covalent amide bond formation using N-(3-dimethylaminopropyl)- N-ethylcarbodiimide hydrochloride, and (III) coating HSA NPs with PEI via covalent bonding using glutaraldehyde for linking amine groups of PEI and amine groups of albumin NPs. Method II was selected since it resulted in a higher shift in the zeta potential value (mV) and less zeta potential value deviation, and also less size polydispersity. GA was loaded by adsorption onto the surface of PEI-HSA NPs of two different sizes: 117 ± 2.9 nm (PEI-P1) and 180 ± 3.1 nm (PEI-P2) NPs. Both GA-entrapment and GA-loading efficiencies increased slightly with the increasing size of NPs, and were affected intensely by the mass ratio of GA to PEI-HSA NPs. Free radical scavenging of GA was quantified based on the 2,2-diphenyl-1-picrylhydrazyl method. The obtained results showed that GA remains active during the preparation of GA-loaded PEI-HSA NPs. The cytotoxicities of HSA, PEI-HSA, and GA-loaded PEI-HSA NPs on the PC-12 cells, as the neuroendocrine cell line, were measured. Our results indicate that positively charged PEI-HSA NPs are good candidates for efficient and safe delivery of GA to the brain.

The implicit effect of texturizing field on the elastic properties of magnetic elastomers revealed by SANS

Energy Technology Data Exchange (ETDEWEB)

Balasoiu, M., E-mail: balas@jinr.ru [Joint Institute of Nuclear Research, Dubna (Russian Federation); Horia Hulubei National Institute for Physics and Nuclear Engineering, Bucharest (Romania); Lebedev, V.T. [St.Petersburg Nuclear Physics Institute NRC KI, Gatchina (Russian Federation); Raikher, Yu.L. [Institute of Continuous Media Mechanics, Russian Academy of Sciences, Ural Branch, Perm (Russian Federation); Bica, I.; Bunoiu, M. [West University of Timisoara, Department of Physics (Romania)

2017-06-01

Small angle neutron scattering method (SANS) is used to characterize the structure properties of the polymer matrix of magnetic elastomers (MEs) of the same material content but with different magnetic textures. For that, series of silicone-rubber elastomers mixed with a ferrofluid and polymerized with/without external magnetic field were studied. In the species of pure rubber and the ME samples synthesized without field, SANS reveals a substantial number of large polymer coils (blobs) which are vertically prolate. The case of MEs polymerized under the magnetic field that is also vertically directed, is different. SANS data indicates that there the blobs are preferably elongated in the direction normal to the field. - Highlights: • SANS method is used to determine the structure of SR elastomers polymerized with ferrofluid in/no external magnetic field. • In the rubber and ME samples synthesized without field, SANS reveals a substantial number of vertically prolate blobs. • For MEs polymerized in vertical magnetic field, results that the blobs are elongated in the direction normal to the field. • Isotropic and texturized MEs differ by the filler structure and by intrinsic elastic properties of the matrix as well.

Auditoría Ambiental para productos lácteos San Pablito

OpenAIRE

Catucuago Toapanta, Luis Alberto

2013-01-01

Productos Lácteos San Pablito, se encuentra ubicada en la comunidad San Pablito de Agualongo, parroquia Tupigachi, cantón Pedro Moncayo en la parte norte de la provincia de Pichincha. Esta Auditoría Ambiental se centró en verificar el cumplimiento de la Legislación Ambiental y el Plan de Manejo Ambiental (PMA) propuesto en el Estudio de Impacto Ambiental (EsIA) del año 2011. La metodología del trabajo comprendió la planificación de la auditoría, visitas técnicas a la planta, evaluación del ma...

San Onofre/Zion auxiliary feedwater system seismic fault tree modeling

International Nuclear Information System (INIS)

Najafi, B.; Eide, S.

1982-02-01

As part of the study for the seismic evaluation of the San Onofre Unit 1 Auxiliary Feedwater System (AFWS), a fault tree model was developed capable of handling the effect of structural failure of the plant (in the event of an earthquake) on the availability of the AFWS. A compatible fault tree model was developed for the Zion Unit 1 AFWS in order to compare the results of the two systems. It was concluded that if a single failure of the San Onofre Unit 1 AFWS is to be prevented, some weight existing, locally operated locked open manual valves have to be used for isolation of a rupture in specific parts of the AFWS pipings

SANS structural characterization of fullerenol-derived star polymers in solutions

CERN Document Server

Jeng, U S; Wang, L Y; Chiang, L Y; Ho, D L; Han, C C

2002-01-01

We have studied the chain conformations of fullerenol-derived star polymers in two organic solvents using small-angle neutron scattering (SANS). The SANS results indicate that the six poly(urethane-ether) arms, chemically bonded on the fullerenol of the C sub 6 sub 0 -based star polymer, have a Gaussian chain conformation in toluene. However, these arms exhibit a pronounced excluded-volume effect in dimethylformamide solutions. We use a scattering model, with the polydispersity of the polymer taken into account, and a fractal model to extract the radius of gyration R sub g values and the persistence lengths of the C sub 6 sub 0 -star polymers in these two organic solutions. (orig.)

L’alimentation des sans-abri

OpenAIRE

Amistani, Carole; Terrolle, Daniel

2012-01-01

L’alimentation des sans-logis est analysable, à partir du terrain, selon deux versants, parfois utilisés conjointement, qui sont celui de leur autonomie et/ou celui de leur dépendance envers le don alimentaire. Dans ce dernier cas, les contenus comme les formes témoignent trop souvent d’une impossibilité d’assurer l’équilibre nutritionnel de ces mangeurs et le respect des multiples aspects socialisants compris dans l’acte alimentaire. Le choix d’un traitement social dans l’ « urgence » et par...

A Tidally Averaged Sediment-Transport Model for San Francisco Bay, California

Science.gov (United States)

Lionberger, Megan A.; Schoellhamer, David H.

2009-01-01

A tidally averaged sediment-transport model of San Francisco Bay was incorporated into a tidally averaged salinity box model previously developed and calibrated using salinity, a conservative tracer (Uncles and Peterson, 1995; Knowles, 1996). The Bay is represented in the model by 50 segments composed of two layers: one representing the channel (>5-meter depth) and the other the shallows (0- to 5-meter depth). Calculations are made using a daily time step and simulations can be made on the decadal time scale. The sediment-transport model includes an erosion-deposition algorithm, a bed-sediment algorithm, and sediment boundary conditions. Erosion and deposition of bed sediments are calculated explicitly, and suspended sediment is transported by implicitly solving the advection-dispersion equation. The bed-sediment model simulates the increase in bed strength with depth, owing to consolidation of fine sediments that make up San Francisco Bay mud. The model is calibrated to either net sedimentation calculated from bathymetric-change data or measured suspended-sediment concentration. Specified boundary conditions are the tributary fluxes of suspended sediment and suspended-sediment concentration in the Pacific Ocean. Results of model calibration and validation show that the model simulates the trends in suspended-sediment concentration associated with tidal fluctuations, residual velocity, and wind stress well, although the spring neap tidal suspended-sediment concentration variability was consistently underestimated. Model validation also showed poor simulation of seasonal sediment pulses from the Sacramento-San Joaquin River Delta at Point San Pablo because the pulses enter the Bay over only a few days and the fate of the pulses is determined by intra-tidal deposition and resuspension that are not included in this tidally averaged model. The model was calibrated to net-basin sedimentation to calculate budgets of sediment and sediment-associated contaminants. While

Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial.

Science.gov (United States)

Li, Edmund K; Tam, Lai-Shan; Wong, Chun Kwok; Li, Wai Ching; Lam, Christopher W K; Wachtel-Galor, Sissi; Benzie, Iris F F; Bao, Yi Xi; Leung, Ping Chung; Tomlinson, Brian

2007-10-15

To examine the efficacy of popular Chinese herbs used in a traditional Chinese medicine (TCM) combination of Ganoderma lucidum and San Miao San (SMS), with purported diverse health benefits including antioxidant properties in rheumatoid arthritis (RA). We randomly assigned 32 patients with active RA, despite disease-modifying antirheumatic drugs, to TCM and 33 to placebo in addition to their current medications for 24 weeks. The TCM group received G lucidum (4 gm) and SMS (2.4 gm) daily. The primary outcome was the number of patients achieving American College of Rheumatology (ACR) 20% response and secondary outcomes included changes in the ACR components, plasma levels, and ex vivo-induced cytokines and chemokines and oxidative stress markers. Eighty-nine percent completed the 24-week study. Fifteen percent in the TCM group compared with 9.1% in the placebo group achieved ACR20 (P > 0.05). Pain score and patient's global score improved significantly only in the TCM group. The percentage, absolute counts, and CD4+/CD8+/natural killer/B lymphocytes ratio were unchanged between groups. CD3, CD4, and CD8 lymphocyte counts and markers of inflammation including plasma interleukin-18 (IL-18), interferon-gamma (IFNgamma)-inducible protein 10, monocyte chemoattractant protein 1, monokine induced by IFNgamma, and RANTES were unchanged. However, in an ex vivo experiment, the percentage change of IL-18 was significantly lower in the TCM group. Thirteen patients reported 22 episodes (14 in placebo group and 8 in TCM group) of mild adverse effects. G lucidum and San Miao San may have analgesic effects for patients with active RA, and were generally safe and well tolerated. However, no significant antioxidant, antiinflammatory, or immunomodulating effects could be demonstrated.

California: Environmental Health Coalition Clean Ports, Healthy Communities in San Diego (A Former EPA CARE Project)

Science.gov (United States)

The Environmental Health Coalition (EHC) is a recipient of a CARE Level II cooperative agreement grant. The Clean Ports, Healthy Communities in San Diego targets the Barrio Logan and Old Town National City areas located along San Diego Bay.

76 FR 5276 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2011-01-31

... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of the... protection, Air pollution control, Incorporation by reference, Intergovernmental relations, Nitrogen dioxide...

40 CFR 180.1108 - Delta endotoxin of Bacillus thuringiensis variety San Diego encapsulated into killed Pseudomonas...

Science.gov (United States)

2010-07-01

... thuringiensis variety San Diego encapsulated into killed Pseudomonas fluorescens; exemption from the requirement... into killed Pseudomonas fluorescens; exemption from the requirement of a tolerance. The delta endotoxin of Bacillus thuringiensis variety San Diego encapsulated into killed Pseudomonas fluorescens is...

76 FR 37044 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2011-06-24

... premature mortality, aggravation of respiratory and cardiovascular disease, decreased lung function... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approve revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of...

Hispanics of a San Diego Barrio.

Science.gov (United States)

1983-04-01

electronic music of Black American discoteques, played loudly on automobile stereo systems or on the oversized "sound boxes" which have more...rider" automobiles , and intense partying are parts of an essentially anti-social image held by the larger San Diego community. Parallels might be drawn...Research Naval Academy, U.S. Annapolis, MD 21402 - .I . . . . I I II I I l i List 7 HRM Officer in Charge Commanding Officer Human Resource Management

Correlation of clayey gouge in a surface exposure of serpentinite in the San Andreas Fault with gouge from the San Andreas Fault Observatory at Depth (SAFOD)

Science.gov (United States)

Moore, Diane E.; Rymer, Michael J.

2012-05-01

Magnesium-rich clayey gouge similar to that comprising the two actively creeping strands of the San Andreas Fault in drill core from the San Andreas Fault Observatory at Depth (SAFOD) has been identified in a nearby outcrop of serpentinite within the fault zone at Nelson Creek. Each occurrence of the gouge consists of porphyroclasts of serpentinite and sedimentary rocks dispersed in a fine-grained, foliated matrix of Mg-rich smectitic clays. The clay minerals in all three gouges are interpreted to be the product of fluid-assisted, shear-enhanced reactions between quartzofeldspathic wall rocks and serpentinite that was tectonically entrained in the fault from a source in the Coast Range Ophiolite. We infer that the gouge at Nelson Creek connects to one or both of the gouge zones in the SAFOD core, and that similar gouge may occur at depths in between. The special significance of the outcrop is that it preserves the early stages of mineral reactions that are greatly advanced at depth, and it confirms the involvement of serpentinite and the Mg-rich phyllosilicate minerals that replace it in promoting creep along the central San Andreas Fault.

The Demise and Rise of the Coy San

Directory of Open Access Journals (Sweden)

Robert J. Gordon

2014-01-01

Full Text Available Review Article:De Jongh, Michael (2012, Roots and Routes: Karretjie People of the Great Karoo: The Marginalisation of a South African First People, Pretoria: UNISA Press, ISBN 978-1-86888-665-4, 220 pp.Glyn, Patricia (2013, What Dawid Knew: A Journey with the Kruipers, Johannesburg: Picador, ISBN 978-1-77010-304-7, 256 pp.Myburgh, Paul John (2013, The Bushman Winter Has Come: The True Story of the Last Band of /Gwikwe Bushmen on the Great Sand Face, Johannesburg: Penguin, ISBN 978-0-14-353066-4, 234 pp.Taylor, Julie J. (2012, Naming the Land: San Identity and Community Conservation in Namibia’s West Caprivi, Basel: Basler Afrika Bibliographien, ISBN 978-3-905758-25-2, 280 pp.Zips-Mairitsch, Manuela (2013, Lost Lands? (Land Rights of the San in Botswana and the Legal Concept of Indigeneity in Africa, Berlin: Lit Verlag, ISBN 978-3-643-90244-3, 430 pp.

76 FR 47076 - Revision to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2011-08-04

... California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District AGENCY... the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of the California...)(2)). List of Subjects in 40 CFR Part 52 Environmental protection, Air pollution control...

76 FR 52623 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2011-08-23

... respiratory and cardiovascular disease, decreased lung function, visibility impairment, and damage to... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approve revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of...

75 FR 28509 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2010-05-21

..., aggravation of respiratory and cardiovascular disease, decreased lung function, visibility impairment, and... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approve revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of...

76 FR 56706 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2011-09-14

... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approve revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of... of Subjects in 40 CFR Part 52 Environmental protection, Air pollution control, Intergovernmental...

Temporal and spatial trends in streamwater nitrate concentrations in the San Bernardino mountains, southern California

Science.gov (United States)

Mark E. Fenn; Mark A. Poth

1999-01-01

We report streamwater nitrate (NO,) concentrations for December 1995 to September 1998 from 19 sampling sites across a N deposition gradient in the San Bernardino Mountains. Streamwater NO3- concentrations in Devil Canyon (DC), a high-pollution area, and in previously reported data from the San Gabriel Mountains 40 km...

Geologic mapping around Mahoma mining. San Jose mining company;Carta geologica de los alrededores de Mina Mahoma, Compania Minera San Jose

Energy Technology Data Exchange (ETDEWEB)

Techera, J; Arrighetii, R

1993-07-01

This study has as main objective carry out a geological mapping as well as the structural analysis , in 1.5.000 scale in the zone where the gold benefit plant of San Jose mining company is settled (Mahoma Mining). From this study has been marked many drillings.

Heavy mineral analysis for assessing the provenance of sandy sediment in the San Francisco Bay Coastal System

Science.gov (United States)

Wong, Florence L.; Woodrow, Donald L.; McGann, Mary

2013-01-01

Heavy or high-specific gravity minerals make up a small but diagnostic component of sediment that is well suited for determining the provenance and distribution of sediment transported through estuarine and coastal systems worldwide. By this means, we see that surficial sand-sized sediment in the San Francisco Bay Coastal System comes primarily from the Sierra Nevada and associated terranes by way of the Sacramento and San Joaquin Rivers and is transported with little dilution through the San Francisco Bay and out the Golden Gate. Heavy minerals document a slight change from the strictly Sierran-Sacramento mineralogy at the confluence of the two rivers to a composition that includes minor amounts of chert and other Franciscan Complex components west of Carquinez Strait. Between Carquinez Strait and the San Francisco Bar, Sierran sediment is intermingled with Franciscan-modified Sierran sediment. The latter continues out the Gate and turns southward towards beaches of the San Francisco Peninsula. The Sierran sediment also fans out from the San Francisco Bar to merge with a Sierran province on the shelf in the Gulf of the Farallones. Beach-sand sized sediment from the Russian River is transported southward to Point Reyes where it spreads out to define a Franciscan sediment province on the shelf, but does not continue southward to contribute to the sediment in the Golden Gate area.

Discovery of amorphous carbon veins in the 2008 Wenchuan earthquake fault zone: implications for the fault weakening mechanism

Science.gov (United States)

Liu, J.; Zhang, J.; Zhang, B.; Li, H.

2013-12-01

The 2008 Wenchuan earthquake generated 270- and 80-km-long surface ruptures along Yingxiu-Beichuan fault and Guanxian-Anxian fault, respectively. At the outcrop near Hongkou village, southwest segment of Yingxiu-Beichuan rupture, network black amorphous carbon veins were discovered near fault planes in the 190-m-wide earthquake fault zone. These veins are mainly composed of ultrafine- and fine-grained amorphous carbon, usually narrower than 5mm and injected into faults and cracks as far as several meter. Flowage structures like asymmetrical structures around few stiff rock fragments indicate materials flew when the veins formed. Fluidization of cataclastic amorphous carbon and the powerful driving force in the veins imply high pore pressure built up during earthquakes. High pore pressure solution and graphite reported in the fault gouge (Togo et al., 2011) can lead very low dynamic friction during the Wenchuan earthquake. This deduction hypothesis is in accordance with the very low thermal abnormal measured on the principle fault zone following the Wenchuan earthquake (Mori et al., 2010). Furthermore, network amorphous carbon veins of different generations suggest similar weakening mechanism also worked on historical earthquakes in Longmenshan fault zone. Reference: Brodsky, E. E., Li, H., Mori, J. J., Kano, Y., and Xue, L., 2012, Frictional Stress Measured Through Temperature Profiles in the Wenchuan Scientific Fault Zone Drilling Project. American Geophysical Union, Fall Meeting. San Francisco, T44B-07 Li, H., Xu, Z., Si, J., Pei, J., Song, S., Sun, Z., and Chevalier, M., 2012, Wenchuan Earthquake Fault Scientific Drilling program (WFSD): Overview and Results. American Geophysical Union, Fall Meeting. San Francisco, T44B-01 Mori, J. J., Li, H., Wang, H., Kano, Y., Pei, J., Xu, Z., and Brodsky, E. E., 2010, Temperature measurements in the WFSD-1 borehole following the 2008 Wenchuan earthquake (MW7.9). American Geophysical Union, Fall Meeting. San Francisco, T53E

Preliminary Geologic Map of the San Fernando 7.5' Quadrangle, Southern California: A Digital Database

Science.gov (United States)

Yerkes, R.F.

1997-01-01

The city of San Fernando sits atop a structurally complex, sedimentologically diverse, and tectonically evolving late Tertiary-Quaternary basin situated within the Transverse Ranges of southern California. The surrounding San Fernando Valley (SFV) contains the headwaters of the Los Angeles River and its tributaries. Prior to the advent of flood control, the valley floor was composed of active alluvial fans and floodplains. Seasonal streams emanating from Pacoima and Big Tujunga Canyons drain the complex western San Gabriel Mountains and deposit coarse, highly permeable alluvium that contains generally high-quality ground water. The more shallow western part derives mainly from Tertiary and pre-Tertiary sedimentary rocks, and is underlain by less permeable, fine-grained deposits containing persistent shallow ground water and poorer water quality. Home of the 1971 San Fernando and the 1994 Northridge earthquakes, the SFV experienced near-record levels of strong ground motion in 1994 that caused widespread damage from strong shaking and ground failure. A new map of late Quaternary deposits of the San Fernando area shows that the SFV is a structural trough that has been filled from the sides, with the major source of sediment being large drainages in the San Gabriel Mountains. Deposition on the major alluvial fan of Tujunga Wash and Pacoima Wash, which issues from the San Gabriel Mountains, and on smaller fans, has been influenced by ongoing compressional tectonics in the valley. Late Pleistocene deposits have been cut by active faults and warped over growing folds. Holocene alluvial fans are locally ponded behind active uplifts. The resulting complex pattern of deposits has a major effect on liquefaction hazards. Young sandy sediments generally are highly susceptible to liquefaction where they are saturated, but the distribution of young deposits, their grain size characteristics, and the level of ground water all are complexly dependent on the tectonics of the valley

Polyethyleneimine grafted short halloysite nanotubes for gene delivery.

Science.gov (United States)

Long, Zheru; Zhang, Jun; Shen, Yan; Zhou, Changren; Liu, Mingxian

2017-12-01

Inorganic nanoparticles have attracted much attentions in gene delivery because of their desirable characteristics including low toxicity, well-controlled characteristics, high gene delivery efficiency, and multi-functionalities. Here, natural occurred halloysite nanotubes (HNTs) were developed as a novel non-viral gene vector. To increase the efficiency of endocytosis, HNTs were firstly shortened into an appropriate size (~200nm). Then polyethyleneimine (PEI) was grafted onto HNTs to bind green fluorescence protein (GFP) labeled pDNA. The structure and physical-chemical properties of PEI grafted HNTs (PEI-g-HNTs) were characterized by various methods. PEI-g-HNTs show lower cytotoxicity than PEI. PEI-g-HNTs are positively charged and can bind DNA tightly at designed N/P ratio from 5:1 to 40:1. PEI-g-HNTs/pDNA complexes show much higher transfection efficiency towards both 293T and HeLa cells compared with PEI/pDNA complexes at the equivalent N/P ratio. The transfection efficiencies of PEI-g-HNTs/pDNA complex towards HeLa cell can reach to 44.4% at N/P ratio of 20. PEI-g-HNTs/pDNA complexes possess a higher GFP protein expression than PEI/pDNA from simple western immunoblots. So, PEI-g-HNTs are potential gene vectors with good biocompatibility and high transfection efficiency, which have promising applications in cancer gene therapy. Copyright © 2017 Elsevier B.V. All rights reserved.

Geothermal resource assessment of western San Luis Valley, Colorado

Energy Technology Data Exchange (ETDEWEB)

Zacharakis, Ted G.; Pearl, Richard Howard; Ringrose, Charles D.

1983-01-01

The Colorado Geological Survey initiated and carried out a fully integrated assessment program of the geothermal resource potential of the western San Luis Valley during 1979 and 1980. The San Luis Valley is a large intermontane basin located in southcentral Colorado. While thermal springs and wells are found throughout the Valley, the only thermal waters found along the western part of the Valley are found at Shaw Warm Springs which is a relatively unused spring located approximately 6 miles (9.66 km) north of Del Norte, Colorado. The waters at Shaws Warm Spring have a temperature of 86 F (30 C), a discharge of 40 gallons per minute and contain approximately 408 mg/l of total dissolved solids. The assessment program carried out din the western San Luis Valley consisted of: soil mercury geochemical surveys; geothermal gradient drilling; and dipole-dipole electrical resistivity traverses, Schlumberger soundings, Audio-magnetotelluric surveys, telluric surveys, and time-domain electro-magnetic soundings and seismic surveys. Shaw Warm Springs appears to be the only source of thermal waters along the western side of the Valley. From the various investigations conducted the springs appear to be fault controlled and is very limited in extent. Based on best evidence presently available estimates are presented on the size and extent of Shaw Warm Springs thermal system. It is estimated that this could have an areal extent of 0.63 sq. miles (1.62 sq. km) and contain 0.0148 Q's of heat energy.

75 FR 1715 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2010-01-13

... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVAPCD) portion of the...)(2)). List of Subjects in 40 CFR Part 52 Environmental protection, Air pollution control...

76 FR 69135 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2011-11-08

... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of the... of Subjects in 40 CFR Part 52 Environmental protection, Air pollution control, Incorporation by...

Cholangitis and multiple liver abscesses after percutaneous ethanol injection (PEI for recurrent hepatocellular carcinoma (HCC Colangitis y abscesos hepáticos múltiples tras la inyección percutánea de etanol (IPE en el tratamiento del carcinoma hepatocelular recurrente

Directory of Open Access Journals (Sweden)

Fernando Macias-García

2013-02-01

Full Text Available Percutaneous ablation procedures are minimally invasive treatments for unresectable early stage hepatocellular carcinoma (HCC. These techniques are usually safe, but rare and even fatal complications have been described. We present a fatal result after percutaneous ethanol injection (PEI for the treatment of a recurrent HCC in a non-cirrhotic liver, with subsequent development of diffuse cholangitis and multiple liver abscesses. Although percutaneous drainage and intensive antibiotic treatment were employed, the patient finally died. We discuss about the etiology and the physiopathology of this rare complication in which the therapeutic options are limited and usually unsuccessful.

Preparation and in vitro characterization of gallic acid-loaded human serum albumin nanoparticles

International Nuclear Information System (INIS)

Mohammad-Beigi, Hossein; Shojaosadati, Seyed Abbas; Morshedi, Dina; Arpanaei, Ayyoob; Marvian, Amir Tayaranian

2015-01-01

Gallic acid (GA), as an antioxidant and antiparkinson agent, was loaded onto cationic human serum albumin nanoparticles (HSA NPs). Polyethylenimine (PEI)-coated HSA (PEI-HSA) NPs were prepared using three different methods: (I) coating negatively charged HSA NPs with positively charged PEI through attractive electrostatic interactions, (II) coating HSA NPs with PEI via covalent amide bond formation using N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, and (III) coating HSA NPs with PEI via covalent bonding using glutaraldehyde for linking amine groups of PEI and amine groups of albumin NPs. Method II was selected since it resulted in a higher shift in the zeta potential value (mV) and less zeta potential value deviation, and also less size polydispersity. GA was loaded by adsorption onto the surface of PEI-HSA NPs of two different sizes: 117 ± 2.9 nm (PEI-P1) and 180 ± 3.1 nm (PEI-P2) NPs. Both GA-entrapment and GA-loading efficiencies increased slightly with the increasing size of NPs, and were affected intensely by the mass ratio of GA to PEI-HSA NPs. Free radical scavenging of GA was quantified based on the 2,2-diphenyl-1-picrylhydrazyl method. The obtained results showed that GA remains active during the preparation of GA-loaded PEI-HSA NPs. The cytotoxicities of HSA, PEI-HSA, and GA-loaded PEI-HSA NPs on the PC-12 cells, as the neuroendocrine cell line, were measured. Our results indicate that positively charged PEI-HSA NPs are good candidates for efficient and safe delivery of GA to the brain

Preparation and in vitro characterization of gallic acid-loaded human serum albumin nanoparticles

Energy Technology Data Exchange (ETDEWEB)

Mohammad-Beigi, Hossein; Shojaosadati, Seyed Abbas, E-mail: shoja-sa@modares.ac.ir [Tarbiat Modares University, Biotechnology Group, Faculty of Chemical Engineering (Iran, Islamic Republic of); Morshedi, Dina; Arpanaei, Ayyoob [National Institute of Genetic Engineering and Biotechnology, Department of Industrial and Environmental Biotechnology (Iran, Islamic Republic of); Marvian, Amir Tayaranian [Aarhus University, Department of Biomedicine (Denmark)

2015-04-15

Gallic acid (GA), as an antioxidant and antiparkinson agent, was loaded onto cationic human serum albumin nanoparticles (HSA NPs). Polyethylenimine (PEI)-coated HSA (PEI-HSA) NPs were prepared using three different methods: (I) coating negatively charged HSA NPs with positively charged PEI through attractive electrostatic interactions, (II) coating HSA NPs with PEI via covalent amide bond formation using N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, and (III) coating HSA NPs with PEI via covalent bonding using glutaraldehyde for linking amine groups of PEI and amine groups of albumin NPs. Method II was selected since it resulted in a higher shift in the zeta potential value (mV) and less zeta potential value deviation, and also less size polydispersity. GA was loaded by adsorption onto the surface of PEI-HSA NPs of two different sizes: 117 ± 2.9 nm (PEI-P1) and 180 ± 3.1 nm (PEI-P2) NPs. Both GA-entrapment and GA-loading efficiencies increased slightly with the increasing size of NPs, and were affected intensely by the mass ratio of GA to PEI-HSA NPs. Free radical scavenging of GA was quantified based on the 2,2-diphenyl-1-picrylhydrazyl method. The obtained results showed that GA remains active during the preparation of GA-loaded PEI-HSA NPs. The cytotoxicities of HSA, PEI-HSA, and GA-loaded PEI-HSA NPs on the PC-12 cells, as the neuroendocrine cell line, were measured. Our results indicate that positively charged PEI-HSA NPs are good candidates for efficient and safe delivery of GA to the brain.

Archiving and retrieval of experimental data using SAN based centralized storage system for SST-1

Energy Technology Data Exchange (ETDEWEB)

Bhandarkar, Manisha, E-mail: manisha@ipr.res.in; Masand, Harish; Kumar, Aveg; Patel, Kirit; Dhongde, Jasraj; Gulati, Hitesh; Mahajan, Kirti; Chudasama, Hitesh; Pradhan, Subrata

2016-11-15

Highlights: • SAN (Storage Area Network) based centralized data storage system of SST-1 has envisaged to address the need of centrally availability of SST-1 storage system to archive/retrieve experimental data for the authenticated users for 24 × 7. • The SAN based data storage system has been designed/configured with 3-tiered architecture and GFS cluster file system with multipath support. • The adopted SAN based data storage for SST-1 is a modular, robust, and allows future expandability. • Important considerations has been taken like, Handling of varied Data writing speed from different subsystems to central storage, Simultaneous read access of the bulk experimental and as well as essential diagnostic data, The life expectancy of data, How often data will be retrieved and how fast it will be needed, How much historical data should be maintained at storage. - Abstract: SAN (Storage Area Network, a high-speed, block level storage device) based centralized data storage system of SST-1 (Steady State superconducting Tokamak) has envisaged to address the need of availability of SST-1 operation & experimental data centrally for archival as well as retrieval [2]. Considering the initial data volume requirement, ∼10 TB (Terabytes) capacity of SAN based data storage system has configured/installed with optical fiber backbone with compatibility considerations of existing Ethernet network of SST-1. The SAN based data storage system has been designed/configured with 3-tiered architecture and GFS (Global File System) cluster file system with multipath support. Tier-1 is of ∼3 TB (frequent access and low data storage capacity) comprises of Fiber channel (FC) based hard disks for optimum throughput. Tier-2 is of ∼6 TB (less frequent access and high data storage capacity) comprises of SATA based hard disks. Tier-3 will be planned later to store offline historical data. In the SAN configuration two tightly coupled storage servers (with cluster configuration) are

Archiving and retrieval of experimental data using SAN based centralized storage system for SST-1

International Nuclear Information System (INIS)

Bhandarkar, Manisha; Masand, Harish; Kumar, Aveg; Patel, Kirit; Dhongde, Jasraj; Gulati, Hitesh; Mahajan, Kirti; Chudasama, Hitesh; Pradhan, Subrata

2016-01-01

Highlights: • SAN (Storage Area Network) based centralized data storage system of SST-1 has envisaged to address the need of centrally availability of SST-1 storage system to archive/retrieve experimental data for the authenticated users for 24 × 7. • The SAN based data storage system has been designed/configured with 3-tiered architecture and GFS cluster file system with multipath support. • The adopted SAN based data storage for SST-1 is a modular, robust, and allows future expandability. • Important considerations has been taken like, Handling of varied Data writing speed from different subsystems to central storage, Simultaneous read access of the bulk experimental and as well as essential diagnostic data, The life expectancy of data, How often data will be retrieved and how fast it will be needed, How much historical data should be maintained at storage. - Abstract: SAN (Storage Area Network, a high-speed, block level storage device) based centralized data storage system of SST-1 (Steady State superconducting Tokamak) has envisaged to address the need of availability of SST-1 operation & experimental data centrally for archival as well as retrieval [2]. Considering the initial data volume requirement, ∼10 TB (Terabytes) capacity of SAN based data storage system has configured/installed with optical fiber backbone with compatibility considerations of existing Ethernet network of SST-1. The SAN based data storage system has been designed/configured with 3-tiered architecture and GFS (Global File System) cluster file system with multipath support. Tier-1 is of ∼3 TB (frequent access and low data storage capacity) comprises of Fiber channel (FC) based hard disks for optimum throughput. Tier-2 is of ∼6 TB (less frequent access and high data storage capacity) comprises of SATA based hard disks. Tier-3 will be planned later to store offline historical data. In the SAN configuration two tightly coupled storage servers (with cluster configuration) are

[Project for the Creation of a Medical or Hospital Ethical Committee at a Local Level in the San Miguel Arcangel Hospital, District of San Miguelito, Province of Panama. Year 2013].

Science.gov (United States)

Díaz Rivera, Yashiro A

2015-01-01

The next project was based on the design on the creation of a medical ethical Committee at a hospital. It was developed at the San Miguel Arcangel Hospital, District of San Miguelito, Province of Panama, in 2013. Insomuch as the creation of social projects requires unified international parameters, format is taken from the Unesco's guides for the establishing and working of bioethics committees; adapted to the socio-economic, political and cultural context of the San Miguelito District, Panama Province. Furthermore to adapting to socio-ecological aspect where the research project is carried out, the theoretical aspect includes from the ontological personalistic bioethics, where the cornerstone is the dignity of the human person. A study of perceptions of medical staff and nursing was developed on the management of the most common ethical dilemmas in the Hospital San Miguel Arcángel. The instrument used was a previously validated perception survey through a pilot test. Reliability was measured using Cronbach's alpha coefficient, and validity was obtained from the content. Satisfactory statistical results, that verify the working hypotheses on the recognition of the importance of autonomy, confidentiality, protection of vulnerable population, occupational health staff welfare and integration of bioethics at the institutional agenda, were obtained. However, there were particular aspects that indicate some doubt as to the management of some realities that are presented in the context of health care.

La Biblioteca Latino Americana: User Survey (San Jose Public Library). Studies in Librarianship No. 2.

Science.gov (United States)

Johnstone, James C.; And Others

To assist a neighborhood committee in applying for federal funding of a bilingual/bicultural library with a distinct Latin American emphasis, a student research group from San Jose State University designed and administered a bilingual questionnaire to a stratified sample of 400 households in the Gardner District of San Jose, California. The…

Sanãtana dharma / René Guénon ; tõlkinud ja kommenteerinud Haljand Udam

Index Scriptorium Estoniae

Guénon, René

2004-01-01

René Guénoni essee "Sanãtana dharma" ilmus 1949. a. ja uuesti 1989. a. raamatus "Études sur ľhindouisme" lk. 105-116 ja käsitleb mõiste "sanãtana dharma" ja "philosophia perennis" tõlgendusi ja tähendust. Esseele on lisatud põhjalik tõlkijapoolne kommentaar

San Jose Accord: energy aid or petroleum-marketing strategy

Energy Technology Data Exchange (ETDEWEB)

1982-09-30

The San Jose Accord was signed in San Jose, Costa Rica on August 3, 1980 by the Presidents of Venezuela and Mexico, whereby the two countries mutually committed to supply the net imported domestic oil consumption of several Central American and Caribbean countries. Countries initially participating in the program are: Barbados, Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Jamaica, Nicaragua, and Panama. Seven eastern Caribbean countries were to meet on October 7 to petition for inclusion in the Accord, namely: Antigua, St. Kitt/Nevis, Montserrat, Dominica, St. Lucia, St. Vincent, and Grenada. The official language of the Accord is presented, and the operative status of the Accord two years after signing is discussed. Specific briefs about some of the individual countries in the Accord are included. The fuel price/tax series for the Western Hemisphere countries is updated.

In vitro efficacy of a gene-activated nerve guidance conduit incorporating non-viral PEI-pDNA nanoparticles carrying genes encoding for NGF, GDNF and c-Jun.

Science.gov (United States)

Lackington, William A; Raftery, Rosanne M; O'Brien, Fergal J

2018-06-07

Despite the success of tissue engineered nerve guidance conduits (NGCs) for the treatment of small peripheral nerve injuries, autografts remain the clinical gold standard for larger injuries. The delivery of neurotrophic factors from conduits might enhance repair for more effective treatment of larger injuries but the efficacy of such systems is dependent on a safe, effective platform for controlled and localised therapeutic delivery. Gene therapy might offer an innovative approach to control the timing, release and level of neurotrophic factor production by directing cells to transiently sustain therapeutic protein production in situ. In this study, a gene-activated NGC was developed by incorporating non-viral polyethyleneimine-plasmid DNA (PEI-pDNA) nanoparticles (N/P 7 ratio, 2μg dose) with the pDNA encoding for nerve growth factor (NGF), glial derived neurotrophic factor (GDNF) or the transcription factor c-Jun. The physicochemical properties of PEI-pDNA nanoparticles, morphology, size and charge, were shown to be suitable for gene delivery and demonstrated high Schwann cell transfection efficiency (60±13%) in vitro. While all three genes showed therapeutic potential in terms of enhancing neurotrophic cytokine production while promoting neurite outgrowth, delivery of the gene encoding for c-Jun showed the greatest capacity to enhance regenerative cellular processes in vitro. Ultimately, this gene-activated NGC construct was shown to be capable of transfecting both Schwann cells (S42 cells) and neuronal cells (PC12 and dorsal root ganglia) in vitro, demonstrating potential for future therapeutic applications in vivo. The basic requirements of biomaterial-based nerve guidance conduits have now been well established and include being able to bridge a nerve injury to support macroscopic guidance between nerve stumps, while being strong enough to withstand longitudinal tension and circumferential compression, in addition to being mechanically sound to facilitate

Migrating tremors illuminate complex deformation beneath the seismogenic San Andreas fault.

Science.gov (United States)

Shelly, David R

2010-02-04

The San Andreas fault is one of the most extensively studied faults in the world, yet its physical character and deformation mode beneath the relatively shallow earthquake-generating portion remain largely unconstrained. Tectonic 'non-volcanic' tremor, a recently discovered seismic signal probably generated by shear slip on the deep extension of some major faults, can provide new insight into the deep fate of such faults, including that of the San Andreas fault near Parkfield, California. Here I examine continuous seismic data from mid-2001 to 2008, identifying tremor and decomposing the signal into different families of activity based on the shape and timing of the waveforms at multiple stations. This approach allows differentiation between activities from nearby patches of the deep fault and begins to unveil rich and complex patterns of tremor occurrence. I find that tremor exhibits nearly continuous migration, with the most extensive episodes propagating more than 20 kilometres along fault strike at rates of 15-80 kilometres per hour. This suggests that the San Andreas fault remains a localized through-going structure, at least to the base of the crust, in this area. Tremor rates and recurrence behaviour changed markedly in the wake of the 2004 magnitude-6.0 Parkfield earthquake, but these changes were far from uniform within the tremor zone, probably reflecting heterogeneous fault properties and static and dynamic stresses decaying away from the rupture. The systematic recurrence of tremor demonstrated here suggests the potential to monitor detailed time-varying deformation on this portion of the deep San Andreas fault, deformation which unsteadily loads the shallower zone that last ruptured in the 1857 magnitude-7.9 Fort Tejon earthquake.

The Church of San Miniato al Monte, Florence: Astronomical and Astrological Connections

Science.gov (United States)

Shrimplin, V.

2011-06-01

The church of San Miniato al Monte is examined in the context of interest in astrology and astronomy in early Renaissance Florence. Vitruvius emphasised the need for architects to "be acquainted with astronomy and the theory of the heavens" in his famous Ten Books of Architecture and, at San Miniato, astronomical and astrological features are combined in order to link humanity with the celestial or spiritual realm. The particular significance of Pisces and Taurus is explored in relation to Christian symbolism, raising questions about the role of astronomy and astrology in art and architecture.

75 FR 76726 - San Luis Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Science.gov (United States)

2010-12-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2196-000] San Luis Solar, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... proceeding of San Luis [[Page 76727

Stenocercus doellojuradoi (Iguanidae, Tropidurinae): una nueva especie para la provincia de San Juan, Argentina

OpenAIRE

Laspiur, Alejandro; Acosta, Juan Carlos

2006-01-01

República Argentina, Provincia de San Juan, Depto. Valle Fértil, 3 km al norte de la localidad de Las Tumanas sobre la Ruta Provincial 510 (30°52’ S, 67°20’ W). COLECTOR: Alejandro Laspiur. FECHA: 25 /02/ 2006. MATERIAL DE REFERENCIA: Instituto y Museo de Ciencias Naturales, Universidad Nacional de San Juan: IMCNUNSJ 3000. Un ejemplar macho (LHC: 54 mm.).

77 FR 214 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2012-01-04

... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approval of revisions to the San Joaquin Valley Air Pollution Control District (SJVUAPCD) portion of the... used by the California Air Resources Board and air districts for evaluating air pollution control...

76 FR 56134 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2011-09-12

... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approve revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of... preempt Tribal law. List of Subjects in 40 CFR Part 52 Environmental protection, Air pollution control...

75 FR 60623 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2010-10-01

... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approval and limited disapproval of revisions to the San Joaquin Valley Unified Air Pollution Control... 30, 2008) \\2\\; and Ventura County Air Pollution Control District (VCAPCD) Rule 74.15 (as amended...

75 FR 57862 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2010-09-23

... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of the... section 307(b)(2)). List of Subjects in 40 CFR Part 52 Environmental protection, Air pollution control...

Impact of a Large San Andreas Fault Earthquake on Tall Buildings in Southern California

Science.gov (United States)

Krishnan, S.; Ji, C.; Komatitsch, D.; Tromp, J.

2004-12-01

In 1857, an earthquake of magnitude 7.9 occurred on the San Andreas fault, starting at Parkfield and rupturing in a southeasterly direction for more than 300~km. Such a unilateral rupture produces significant directivity toward the San Fernando and Los Angeles basins. The strong shaking in the basins due to this earthquake would have had a significant long-period content (2--8~s). If such motions were to happen today, they could have a serious impact on tall buildings in Southern California. In order to study the effects of large San Andreas fault earthquakes on tall buildings in Southern California, we use the finite source of the magnitude 7.9 2001 Denali fault earthquake in Alaska and map it onto the San Andreas fault with the rupture originating at Parkfield and proceeding southward over a distance of 290~km. Using the SPECFEM3D spectral element seismic wave propagation code, we simulate a Denali-like earthquake on the San Andreas fault and compute ground motions at sites located on a grid with a 2.5--5.0~km spacing in the greater Southern California region. We subsequently analyze 3D structural models of an existing tall steel building designed in 1984 as well as one designed according to the current building code (Uniform Building Code, 1997) subjected to the computed ground motion. We use a sophisticated nonlinear building analysis program, FRAME3D, that has the ability to simulate damage in buildings due to three-component ground motion. We summarize the performance of these structural models on contour maps of carefully selected structural performance indices. This study could benefit the city in laying out emergency response strategies in the event of an earthquake on the San Andreas fault, in undertaking appropriate retrofit measures for tall buildings, and in formulating zoning regulations for new construction. In addition, the study would provide risk data associated with existing and new construction to insurance companies, real estate developers, and

Synthetic seismicity for the San Andreas fault

Directory of Open Access Journals (Sweden)

S. N. Ward

1994-06-01

Full Text Available Because historical catalogs generally span only a few repetition intervals of major earthquakes, they do not provide much constraint on how regularly earthquakes recur. In order to obtain better recurrence statistics and long-term probability estimates for events M ? 6 on the San Andreas fault, we apply a seismicity model to this fault. The model is based on the concept of fault segmentation and the physics of static dislocations which allow for stress transfer between segments. Constraints are provided by geological and seismological observations of segment lengths, characteristic magnitudes and long-term slip rates. Segment parameters slightly modified from the Working Group on California Earthquake Probabilities allow us to reproduce observed seismicity over four orders of magnitude. The model yields quite irregular earthquake recurrence patterns. Only the largest events (M ? 7.5 are quasi-periodic; small events cluster. Both the average recurrence time and the aperiodicity are also a function of position along the fault. The model results are consistent with paleoseismic data for the San Andreas fault as well as a global set of historical and paleoseismic recurrence data. Thus irregular earthquake recurrence resulting from segment interaction is consistent with a large range of observations.

Psychiatric Disorders and Substance Use in Homeless Youth: A Preliminary Comparison of San Francisco and Chicago

Directory of Open Access Journals (Sweden)

Ernika G. Quimby

2012-08-01

Full Text Available Youth homelessness is a growing problem in the United States. The experience of homelessness appears to have numerous adverse consequences, including psychiatric and substance use disorders. This study compared the frequencies of psychiatric disorders, including substance use, between homeless youth (18–24 years-old in San Francisco (N = 31 and Chicago (N = 56. Subjects were administered the Mini International Neuropsychiatric Interview (M.I.N.I. to assess DSM-IV-TR diagnoses and substance use disorders. Eighty-seven percent of the San Francisco youth, and 81% of the Chicago youth met criteria for at least one M.I.N.I. psychiatric diagnosis. Nearly two-thirds of the youth in both samples met criteria for a mood disorder. Approximately one-third met criteria for an anxiety disorder. Thirty-two percent of the San Francisco sample and 18% of the Chicago met criteria for Antisocial Personality Disorder. Approximately 84% of the San Francisco youth and 48% of the Chicago youth met criteria for a substance-related disorder, and more substances were used by San Francisco youth. In conclusion, the high rate of psychiatric disorders in homeless youth provides clear evidence that the mental health needs of this population are significant. Implications are discussed.

A jewel in the desert: BHP Billiton's San Juan underground mine

Energy Technology Data Exchange (ETDEWEB)

Buchsbaum, L.

2007-12-15

The Navajo Nation is America's largest native American tribe by population and acreage, and is blessed with large tracks of good coal deposits. BHP Billiton's New Mexico Coal Co. is the largest in the Navajo regeneration area. The holdings comprise the San Juan underground mine, the La Plata surface mine, now in reclamation, and the expanding Navajo surface mine. The article recounts the recent history of the mines. It stresses the emphasis on sensitivity to and helping to sustain tribal culture, and also on safety. San Juan's longwall system is unique to the nation. It started up as an automated system from the outset. Problems caused by hydrogen sulfide are being tackled. San Juan has a bleederless ventilation system to minimise the risk of spontaneous combustion of methane and the atmospheric conditions in the mine are heavily monitored, especially within the gob areas. 3 photos.

SANS contrast variation on a dendrimer host-guest complex

NARCIS (Netherlands)

Kleppinger, R.; Mortensen, K.; Meijer, E.W.

2002-01-01

Small-angle neutron scattering (SANS) technique was used to study the configurational changes in an oligoethyleneoxy-functionalized poly(propyleneimine) dendrimer (host) when forming complexes with rose bengal (guest). Guinier fits to the scattering data recorded at max. contrast indicated a

San Diego Littoral Cell CRSMP Potential Offshore Borrow Areas 2009

Data.gov (United States)

California Natural Resource Agency — Offshore sediment sources along the entire reach of the San Diego Coastal RSM Plan region were previously identified by SANDAG and used for Regional Beach Sand...

76 FR 56132 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Science.gov (United States)

2011-09-12

... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approve revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of... did the State submit? B. Are there other versions of this rule? C. What is the purpose of the...

Primary structure and subcellular localization of two fimbrial subunit-like proteins involved in the biosynthesis of K99 fibrillae.

Science.gov (United States)

Roosendaal, E; Jacobs, A A; Rathman, P; Sondermeyer, C; Stegehuis, F; Oudega, B; de Graaf, F K

1987-09-01

Analysis of the nucleotide sequence of the distal part of the fan gene cluster encoding the proteins involved in the biosynthesis of the fibrillar adhesin, K99, revealed the presence of two structural genes, fanG and fanH. The amino acid sequence of the gene products (FanG and FanH) showed significant homology to the amino acid sequence of the fibrillar subunit protein (FanC). Introduction of a site-specific frameshift mutation in fanG or fanH resulted in a simultaneous decrease in fibrillae production and adhesive capacity. Analysis of subcellular fractions showed that, in contrast to the K99 fibrillar subunit (FanC), both the FanH and the FanG protein were loosely associated with the outer membrane, possibly on the periplasmic side, but were not components of the fimbriae themselves.

The new 'BerSANS-PC' software for reduction and treatment of small angle neutron scattering data

International Nuclear Information System (INIS)

Keiderling, U.

2002-01-01

Measurements on small angle neutron scattering (SANS) instruments are typically characterized by a large number of samples, short measurement times for the individual samples, and a frequent change of visiting scientist groups. Besides this, recent advances in instrumentation have led to more frequent measurements of kinetic sequences and a growing interest in analyzing two-dimensional scattering data, these requiring special software tools that enable the users to extract physically relevant information from the scattering data with a minimum of effort. The new 'BerSANS-PC' data-processing software has been developed at the Hahn-Meitner-Institut (HMI) in Berlin, Germany, to meet these requirements and to support an efficiently working guest-user service. Comprising some basic functions of the 'BerSANS' program available at the HMI and other institutes in the past, BerSANS-PC is a completely new development for network-independent use on local PCs with a full-feature graphical interface. (orig.)

San Bernardino National Wildlife Refuge Well 10

Energy Technology Data Exchange (ETDEWEB)

Ensminger, J.T.; Easterly, C.E.; Ketelle, R.H.; Quarles, H.; Wade, M.C.

1999-12-01

The U.S. Geological Survey (USGS), at the request of the U.S. Fish and Wildlife Service, evaluated the water production capacity of an artesian well in the San Bernardino National Wildlife Refuge, Arizona. Water from the well initially flows into a pond containing three federally threatened or endangered fish species, and water from this pond feeds an adjacent pond/wetland containing an endangered plant species.

Origen, protagonistas y alianzas. El Banco de San Luis Potosí, 1897-1916

Directory of Open Access Journals (Sweden)

Moisés Gámez Rodriguez

2017-04-01

Full Text Available En este trabajo se expone el origen de la banca en San Luis Potosí, cuyo estudio se centra a partir de la legislación bancaria de 1897, que representa históricamente la institucionalización y modernización de la empresa bancaria mexicana. Como punto de partida se plantea que los perfiles financieros y empresariales de los involucrados en el nacimiento del Banco de San Luis Potosí, y representados en los miembros de su Consejo de Administración, son importantes para entender la configuración del sistema, y también que las redes extendidas en torno a dicha empresa muestran prácticas financieras de la economía de México en el último cuarto del siglo XIX. _________________________ This article explains the origin of banking in San Luis Potosi from the legislation in 1897, which historically represents the institutionalization and modernization of Mexican banking companies. As a starting point, it argues that financial and business profiles of those involved in the birth of Bank of San Luis Potosi and represented in the Board of Directors are important to understand the system configuration. Furthermore, the networks extended around the banking company show financial practices of Mexican economy in the last quarter of the 19th century.

Low-Molecular Weight Polyethylenimine Modified with Pluronic 123 and RGD- or Chimeric RGD-NLS Peptide: Characteristics and Transfection Efficacy of Their Complexes with Plasmid DNA

Directory of Open Access Journals (Sweden)

Jing Hu

2016-05-01

Full Text Available To solve the problem of transfection efficiency vs. cytotoxicity and tumor-targeting ability when polyethylenimine (PEI was used as a nonviral gene delivery vector, new degradable PEI polymers were synthesized via cross-linking low-molecular-weight PEI with Pluronic P123 and then further coupled with a targeting peptide R4 (RGD and a bifunctional R11 (RGD-NLS, which were termed as P123-PEI-R4 and P123-PEI-R11, respectively. Agarose gel electrophoresis showed that both P123-PEI-R4 and P123-PEI-R11 efficaciously condense plasmid DNA at a polymer-to-pDNA w/w ratio of 3.0 and 0.4, respectively. The polyplexes were stable in the presence of serum and could protect plasmid DNA against DNaseI. They had uniform spherical nanoparticles with appropriate sizes around 100–280 nm and zeta-potentials about +40 mV. Furthermore, in vitro experiments showed that these polyplexes had lower cytotoxicity at any concentration compared with PEI 25 kDa, thus giving promise to high transfection efficiency as compared with another P123-PEI derivate conjugated with trifunctional peptide RGD-TAT-NLS (P123-PEI-R18. More importantly, compared with the other polymers, P123-PEI-R11 showed the highest transfection efficiency with relatively lower cytotoxicity at any concentration, indicating that the new synthetic polymer P123-PEI-R11 could be used as a safe and efficient gene deliver vector.

Port San Luis, California Tsunami Forecast Grids for MOST Model

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Port San Luis, California Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

SANS facility at the Pitesti 14 MW Triga reactor

International Nuclear Information System (INIS)

Ionita, I.; Anghel, E.; Mincu, M.; Datcu, A.; Grabcev, B.; Todireanu, S.; Constantin, F.; Shvetsov, V.; Popescu, G.

2006-01-01

Full text of publication follows: At the present time, an important not yet fully exploited potentiality is represented by the SANS instruments existent at lower power reactors and reactors in developing countries even if they are, generally, endowed with a simpler equipment and are characterized by the lack of infrastructure to maintain and repair high technology accessories. The application of SANS at lower power reactors and in developing countries nevertheless is possible in well selected topics where only a restricted Q range is required, when scattering power is expected to be sufficiently high or when the sample size can be increased at the expense of resolution. Examples of this type of applications are: 1) Phase separation and precipitates in material science, 2) Ultrafine grained materials (nano-crystals, ceramics), 3) Porous materials such as concretes and filter materials, 4) Conformation and entanglements of polymer-chains, 5) Aggregates of micelles in microemulsions, gels and colloids, 6) Radiation damage in steels and alloys. The need for the installation of a new SANS facility at the Triga Reactor of the Institute of Nuclear Researches in Pitesti, Romania become actual especially after the shutting down of the VVRS Reactor from Bucharest. A monochromatic neutron beam with 1.5 Angstrom ≤ λ ≤ 5 Angstrom is produced by a mechanical velocity selector with helical slots.The distance between sample and detectors plane is (5.2 m ). The sample width may be fixed between 10 mm and 20 mm. The minimum value of the scattering vector is Q min = 0.005 Angstrom -1 while the maximal value is Q max = 0.5 Angstrom -1 . The relative error is ΔQ/Q min = 0.5. The cooperation partnership between advanced research centers and the smaller ones from developing countries could be fruitful. The formers act as mentors in solving specific problems. Such a partnership was established between INR Pitesti, Romania and JINR Dubna, Russia. The first step in this cooperation

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Author Affiliations. Fang Dong1 Jiang Chenning1 Zhu Ting1 Yang Jinming1. Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Yancheng Teachers University, 50 Kai Fang Da Dao, Yancheng 224002, Jiangsu, P. R. China ...

MASSIVE QUANTITIES OF PELAGIC Sargassum ON THE SHORES OF SAN ANDRES ISLAND, SOUTHWESTERN CARIBBEAN

Directory of Open Access Journals (Sweden)

Brigitte GAVIO

2015-01-01

Cantidades masivas de Sargassum pelágicos en las costas de San Andrés Isla, Caribe suroccidental Se reporta la llegada de una biomasa inusual de Sargassum flotante, compuesta por las especies S. fluitans y S. natans, a la costa nororiental de la isla de San Andrés. La época y el tamaño del evento nunca habían sido reportados anteriormente para la isla.

Stenocercus doellojuradoi (Iguanidae, Tropidurinae: una nueva especie para la provincia de San Juan, Argentina

Directory of Open Access Journals (Sweden)

Laspiur, Alejandro

2006-05-01

Full Text Available República Argentina, Provincia de San Juan, Depto. Valle Fértil, 3 km al norte de la localidad de Las Tumanas sobre la Ruta Provincial 510 (30°52’ S, 67°20’ W. COLECTOR: Alejandro Laspiur. FECHA: 25 /02/ 2006. MATERIAL DE REFERENCIA: Instituto y Museo de Ciencias Naturales, Universidad Nacional de San Juan: IMCNUNSJ 3000. Un ejemplar macho (LHC: 54 mm..

Amphibians and reptiles of the state of San Luis Potosí, Mexico, with comparisons with adjoining states.

Science.gov (United States)

Lemos-Espinal, Julio A; Smith, Geoffrey R; Woolrich-Piña, Guillermo A

2018-01-01

A summary of the species of amphibians and reptiles of the state has been compiled, including their geographic distributions, habitats, and conservation statuses. The herpetofauna of San Luis Potosí consists of 41 species of amphibians and 141 species of reptiles. San Luis Potosí shares the highest number of species with Hidalgo and Tamaulipas, and the least number of species with Nuevo León. In San Luis Potosí, there are several taxa of particular conservation concern including salamanders, emydid and trionychid turtles, anguid and xenosaurid lizards, and natricid and colubrid snakes.

JPRS Report, East Asia, Vietnam: TAP CHI CONG SAN, No. 10, October 1987

Science.gov (United States)

1988-02-09

Followers in the Countries of Latin America [ Tran Anh] 48 JPRS-ATC-88-002 9 February 1988 VIETNAM: TAP CHI CONG SAN No 10, October 1987 [Except...character is not simply an ideological-political category applied in literature. Our party, as Truong Chinh said at the Third National Literature and Art...Hanoi TAP CHI CONG SAN in Vietnamese No 10, Oct 87pp 39-42 [Article by Nguyen Dang Quang, assistant editor-in-chief of GIAO DUC LY LUAN Journal