Linguaggio e corpo delle emozioni. Dewey, Nussbaum e la lingua di Saba

Directory of Open Access Journals (Sweden)

Roberta Dreon

2012-05-01

Full Text Available The essay aims at drawing a comparison between Dewey’s theory of emotions and Nussbaum’s one, focusing the role of «corporeity» in human experience of emotions. Both the theories  are empirical verified by examinig a short story by Umberto Saba, Ernesto, wich the Roberta Dreon assumes as pertinent example of a narrative, literary way to express emotions.

Predation threats to the Red-billed Tropicbird breeding colony of Saba: focus on cats

NARCIS (Netherlands)

Debrot, A.O.; Ruijter, M.; Endarwin, W.; Hooft, van P.; Wulf, K.

2014-01-01

Feral domestic cats (Felis catus) are recognized as one of the most devastating alien predator species in the world and are a major threat to nesting colonies of the Red-billed Tropicbird (Phaethon aethereus), on Saba island, Dutch Caribbean. Cats and rats are both known to impact nesting seabirds

Use of satellite data for the monitoring of species on Saba and St. Eustatius

OpenAIRE

Smith, S.R.; Mücher, C.A.; Debrot, A.O.; Roupioz, L.F.S.; Meesters, H.W.G.; Hazeu, G.W.; Davaasuren, N.

2013-01-01

The present study examines the possibility to identify the different land cover types (natural and artificial) on very high resolution satellite images of the Caribbean islands Bonaire, Saba and St. Eustatius. Linking species habitat requirements with associated land cover types allows for the identification of their potential occurence on the islands.

The library of evaluated and experimental data on charged particles for fusion application (SaBa). Summary documentation

International Nuclear Information System (INIS)

Zvenigorodskij, A.G.; Zherebtsov, V.A.; Lazarev, L.M.; Dunaeva, S.A.; Generalov, L.N.; Taova, S.M.; Kamskaya, E.V.; Marshalkina, R.I.

1999-01-01

An electronic version of the evaluated and experimental data on charged particles for thermonuclear applications (SaBa) was prepared on the base of handbook 'Nuclear Physics Constants for Thermonuclear Fusion', INDC(CCP)-326/L+F, Vienna, 1991. Data on 100 channels for 52 reactions are presented in the Library. Program code was performed using the object-oriented programming environment Borland C ++ Builder for Microsoft Windows 95 and Windows NT operating systems. Optimal set of data processing procedures and friendly interface provide remarkable possibilities for the active use of this program for various applications in the field of thermonuclear fusion. It is available online (http:/www-nds.iaea.or.at/reports/data/saba/disk1.zip, ../disk2.zip, ../disk3.zip, on CD-ROM or on a set of PC diskettes from the IAEA Nuclear Data Section, costfree, upon request. (author)

78 FR 802 - Heart of Texas Railroad, L.P.-Acquisition and Operation Exemption-Gulf Colorado & San Saba...

Science.gov (United States)

2013-01-04

... Railroad, L.P.--Acquisition and Operation Exemption--Gulf Colorado & San Saba Railway Company Heart of Texas Railroad, L.P. (the Company), a noncarrier, has filed a verified notice of exemption under 49 CFR..., 2013. Rachel D. Campbell, Director, Office of Proceedings. Jeffrey Herzig, Clearance Clerk. [FR Doc...

Technical evaluation of a potential release of OX513A Aedes aegypti mosquitoes on the island of Saba

NARCIS (Netherlands)

Glandorf DCM; GBV; M&V

2017-01-01

The mosquito Aedes aegypti transmits viruses that cause diseases such as dengue, chikungunya and zika. Measures are taken to control the mosquito since these infectious diseases represent a significant health problem. This is the case on the island of Saba, a Dutch Caribbean island. In order to

Diffevential Diagnosis of Frimary Stuttering and Normal Nonfluency in Children Referring to Saba Clinic

Directory of Open Access Journals (Sweden)

Fariba Yadegari

2003-12-01

Full Text Available Objective: Early Diagnosis and intervention of primary stuttering is the key for prevention of chronic developmental stuttering. Normal nonfluency of children under 5 years old is an important differential diagnosis of primary stuttering. The goals of this research are finding accuracy of diagnoses on children referred to Saba speech therapy Clinic labeled as normal nonfluency and introducing move precise methods of differential diagnosis.  Materials & Methods: The research method is case series study in which through simple sampling procedure stuttering children referring to SabA Clinic during 1382 & 83 were studied. 10. Research tools and data collection consist of: questionnair, spontaneous speech sample recording and determining VOT using laryngograph processor. It should be noted that because normative date of stutteres VOT the lack of the normal subjects VOT are analysed and comared with stutterers. Results: Based on numerical criteria, our findings indicate that only one of stutterers was normal nonfluent and the others were stutteres. VOT data of stutteres also were compared to that of normal matched children. The results revealed that all of stutterers had significantly (P<0.05 longer VOT than normal subjects . Conclusion: This study provides a good numeric and clinical index for speech language pathologists for diagnosis of primary stuttering and normal nonfluency. Morover,. using VOT would help accurate diagnosis.

New energy vision at Sabae City. Toward realization of 'environmental international city'; 2001 nendo Sabae shi chiiki shin energy vision. Kankyo kokusai toshi Sabae no jitsugen ni mukete

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-03-01

With an object of accelerating introduction of and uplifting consciousness on new energies at Sabae City in Fukui Prefecture, a new energy vision was put into order based on the result of the initial stage investigation having been performed in the previous fiscal year. Solar light and solar heat energies will be introduced positively into public facilities, and at the same time works will be implemented to accelerate the proliferation thereof into general households. The target of introduction by the year 2010y is set to 2,600 kW by photovoltaic power generation, and the introduction thereof is planned to schools, nursery schools, municipality operated houses, and unattended facilities. With regard to solar heat water warmer, the present proliferation rate of about 7.3% will be raised to 15%. Regarding wastes generated from industrial areas, efficient energy extraction by thermal recycling is intended on the assumption of suppression of wastes generation, their re-use, and recycling. Systems may include the bio-gas system, cogeneration, and recovery of energies from plastics wastes. For acceleration of proliferation of new energies in general, promotion of introduction will be achieved on mini-wind power generation, small hydroelectric power generation, and fuel cell automobiles. (NEDO)

New energy vision at Sabae City. Toward realization of 'environmental international city'; 2001 nendo Sabae shi chiiki shin energy vision. Kankyo kokusai toshi Sabae no jitsugen ni mukete

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-03-01

With an object of accelerating introduction of and uplifting consciousness on new energies at Sabae City in Fukui Prefecture, a new energy vision was put into order based on the result of the initial stage investigation having been performed in the previous fiscal year. Solar light and solar heat energies will be introduced positively into public facilities, and at the same time works will be implemented to accelerate the proliferation thereof into general households. The target of introduction by the year 2010y is set to 2,600 kW by photovoltaic power generation, and the introduction thereof is planned to schools, nursery schools, municipality operated houses, and unattended facilities. With regard to solar heat water warmer, the present proliferation rate of about 7.3% will be raised to 15%. Regarding wastes generated from industrial areas, efficient energy extraction by thermal recycling is intended on the assumption of suppression of wastes generation, their re-use, and recycling. Systems may include the bio-gas system, cogeneration, and recovery of energies from plastics wastes. For acceleration of proliferation of new energies in general, promotion of introduction will be achieved on mini-wind power generation, small hydroelectric power generation, and fuel cell automobiles. (NEDO)

Monitoring the effect of cat removal on reproductive success in Red-billed Tropicbird colonies on Saba, 2013 - 2014: first season of results

NARCIS (Netherlands)

Terpstra, M.; Woude, van der E.; Wulf, K.; Rijn, van J.; Debrot, A.O.

2015-01-01

One of the most deleterious invasive introduced predators worldwide is the domestic cat which has been found responsible for many island extinctions worldwide. Cats can live off both natural prey and garbage and can be a particularly serious threat to ground-nesting bird populations. Saba is an

Genetic diversity of avenin-like b genes in Aegilops tauschii Coss.

Science.gov (United States)

Cao, Dong; Wang, Hongxia; Zhang, Bo; Liu, Baolong; Liu, Dengcai; Chen, Wenjie; Zhang, Huaigang

2018-02-01

Avenin-like storage proteins influence the rheological properties and processing quality in common wheat, and the discovery of new alleles will benefit wheat quality improvement. In this study, 13 avenin-like b alleles (TaALPb7D-A-M) were discovered in 108 Aegilops tauschii Coss. accessions. Ten alleles were reported for the first time, while the remaining three alleles were the same as alleles in other species. A total of 15 nucleotide changes were detected in the 13 alleles, resulting in only 11 amino acid changes because of synonymous mutations. Alleles TaALPb7D-E, TaALPb7D-G, and TaALPb7D-J encoded the same protein. These polymorphic sites existed in the N-terminus, Repetitive region (Left), Repetitive region (Right) and C-terminus domains, with no polymorphisms in the signal peptide sequence nor in those encoding the 18 conserved cysteine residues. Phylogenetic analysis divided the TaALPb7Ds into four clades. The Ae. tauschii alleles were distributed in all four clades, while the alleles derived from common wheat, TaALPb7D-G and TaALPb7D-C, belonged to clade III and IV, respectively. Alleles TaALPb7D-G and TaALPb7D-C were the most widely distributed, being present in nine and six countries, respectively. Iran and Turkey exhibited the highest genetic diversity with respect to TaALPb7D alleles, accessions from these countries carrying seven and six alleles, respectively, which implied that these countries were the centers of origin of the avenin-like b gene. The new alleles discovered and the phylogenetic analysis of avenin-like b genes will provide breeding materials and a theoretical basis for wheat quality improvement.

Evaluation of dynamic enhanced CT scanning in the differentiation of adrenal lipid-poor adenomas with metastases

International Nuclear Information System (INIS)

Fang Xiangming; Hu Chunhong; Hu Xiaoyun; Chen Hongwei; Wu Liyuan; Zou Xinnong; Qian Pingyan

2006-01-01

Objective: To evaluate dynamic enhanced CT in differentiating adrenal metastases from adrenal lipid-poor adenomas(ALPA). Methods: Both plain and dynamic enhanced CT scanning was performed in 9 metastases with 13 masses and 28 lipid-poor adenoma with 30 masses. The types of time-density curve according to peak time(PT) and relative washout percentage(Washr) besides shape, size, margin, internal structure, surrounding status and enhanced pattern of each lesion were measuerd and compared between the two groups of metastases and ALPA. Results: There is difference between metastases and ALPA in the aspects of shape, density, neighboring structure and the type of enhancement. The type of TDC of matastases was characterized by fast-washin and fast-washout, which was quite differed from the type of TDC of ALPA characterized by fast-washin and slow-washout. According to this, the sensitiveity and specificity for differentiating metastases from ALPA were 96.7%, 92.3%. Conclusion: The types of TDC of dynamic enhanced CT is of great value in differentiating metastases from ALPA. (authors)

INFLUENCE OF MECHANICAL ALLOYING AND LEAD CONTENT ON MICROSTRUCTURE, HARDNESS AND TRIBOLOGICAL BEHAVIOR OF 6061 ALUMINIUM ALLOYS

Directory of Open Access Journals (Sweden)

M. Paidpilli

2017-03-01

Full Text Available In the present work, one batch of prealloyed 6061Al powder was processed by mixing and another one was ball milled with varying amount of lead content (0-15 vol. %. These powders were compacted at 300MPa and sintered at 590˚C under N2. The instrumented hardness and the young’s modulus of as-sintered 6061Al-Pb alloys were examined as a function of lead content and processing route. The wear test under dry sliding condition has been performed at varying loads (10-40 N using pin-on-disc tribometer. The microstructure and worn surfaces have been investigated using SEM to evaluate the change in topographical features due to mechanical alloying and lead content. The mechanically alloyed materials showed improved wear characteristics as compared to as-mixed counterpart alloys. Delamination of 6061Al-Pb alloys decreases up to an optimum lead composition in both as-mixed and ball-milled 6061Al-Pb alloys. The results indicated minimum wear rate for as-mixed and ball-milled 6061Al alloy at 5 and 10 vol. % Pb, respectively.

The Rate of Low Vision Aids Usage after Prescription at the Saba and Khazaneh Clinics in Low Vision Clients

Directory of Open Access Journals (Sweden)

Nasser Sadegh-Pour

2008-04-01

Full Text Available Objective: This research was aimed to determine the rate of low vision aids uses by low vision clients in their daily living. Materials & Methods: In this descriptive study that was done at the Saba and Khazaneh clinics, 50 people from low vision clients were selected by convenient sampling during 2005 & 2006. One questionnaire was completed by therapist at the first time of optometric examination and useful low vision aid (LVA has been prescript and given to clients. After three months (at least they should came back to center and fill the second form. The first form was about functional vision without LVA and second too, but by using of LVA. They have been compared to fulfill the result of research. Data were analyzed by Spearman correlation coefficient, Chi – square and Wilcoxon tests. Results: Spearman correlation coefficient between use of LVAs for near with duration and frequency of study were 0/491 and 0/520 with probability values such as P=0/003 and P=0/002 that shown significant relation. There was significant difference in traffic measure and environment knowing between before and after of far LVAs using (P=0/002 and their SCC was 0/499. There was significant relation between use of low vision aid and education after prescription (P=0/011. Conclusion: However the LVAs improve vision of low vision person, but many of them don’t use by different reasons.

Liquid poison injection system (LPIS) for KAIGA 1, 2 and RAPP 3, 4, 220 MWe PHWRs

International Nuclear Information System (INIS)

Soni, K.L.; Aparna; Mohan, L.R.; Nema, M.K.; Mahajan, S.C.

1997-01-01

LPIS is the modified version of existing Bulk Addition Mode (BAM) of the Automatic Liquid Poison Addition System (ALPAS). This BAM mode of ALPAS serves as slow acting supplementary shutdown system to PSS or SS as the case may be and hence it becomes a part of reactor safety system. The system (LPIS) has been envisaged to perform similar functions of ALPAS mode BAM. Now this is a self standing system. This feature of the system eliminates need of Gravity Addition of Boron System (GRAB). As the concept evolved is to be introduced for first time for the power reactors (from KAIGA-1, 2 and RAPP-3, 4 onwards), it has become necessary to check and verify its working by carrying out the necessary experimental and developmental work

Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups.

Science.gov (United States)

Padhukasahasram, B; Yang, J J; Levin, A M; Yang, M; Burchard, E G; Kumar, R; Kwok, P-Y; Seibold, M A; Lanfear, D E; Williams, L K

2014-08-01

Inhaled short-acting beta-agonist (SABA) medication is commonly used in asthma patients to rapidly reverse airway obstruction and improve acute symptoms. We performed a genome-wide association study of SABA medication response using gene-based association tests. A linear mixed model approach was first used for single-nucleotide polymorphism associations, and the results were later combined using GATES to generate gene-based associations. Our results identified SPATA13-AS1 as being significantly associated with SABA bronchodilator response in 328 healthy African Americans. In replication, this gene was associated with SABA response among the two separate groups of African Americans with asthma (n=1073, P=0.011 and n=1968, P=0.014), 149 healthy African Americans (P=0.003) and 556 European Americans with asthma (P=0.041). SPATA13-AS1 was also associated with longitudinal SABA medication usage in the two separate groups of African Americans with asthma (n=658, P=0.047 and n=1968, P=0.025). Future studies are needed to delineate the precise mechanism by which SPATA13-AS1 may influence SABA response.

Caracterización petrográfica y geoquímica del batolito Cerro Aspero-Alpa Corral (32°34'-32°42' LS y 64°43'-64°52' LO, provincia de Córdoba, Argentina

Directory of Open Access Journals (Sweden)

Porta, G.

1992-12-01

Full Text Available The Cerro Aspero-Alpa Corral (CA-AC batholith is a 440 km2 granite body present in the Southern edge of the Eastern Pampean Ranges, Córdoba province, central Argentina. The intrusive body of probably paleozoic age shows both post-tectonic and epizonal character. Country rocks include Upper Precambrian-Lower Paleozoic metasedimentary rocks mainly represented by mica-schists, gneisses and migmatites, locally interrupted by minor amphibolite and marble outcrops.This paper deals with representative petrographic and geochemical data that characterize a 150 km2 central stripe between 32°34'-32°42'S and 64°43'-64°52'W.Three granitic facies have been distinguished based on their distinctive modal mineralogy and texture, and upon well known chemical parameters.A K-feldspar megacryst porphydic-type is the areally prevalent facies, but dykes of micro- leucogranites and biotite-phenocryst bearing granite are also well represented. They are all monzogranites of subalkaline and peraluminous chemistry. Their mineralogy shows variable proportions of QAP constituents and micas, with minor phases represented by Fe-Ti oxides, apatite (Ap, titanite (Tt, allanite (Aln.Microgranular enclaves, abundantly distributed in the porphydic facies, provide valuable information for a better understanding of parental magma evolution.The high-Ca content of the melt makes this body quite distinctive compared to its larger northern neighbour, the Achala batholith.Pegmatite and aplite bodies, as well as fluorite bearing breccias and quartz veins, barren or mineralized, are also present within the CA-AC batholith.El batolito Cerro Aspero-Alpa Corral (CA-AC es un cuerpo granítico que aflora en el extremo sur de las Sierras Pampeanas Orientales, en la provincia de Córdoba, República Argentina, cubriendo una superficie cercana a los 440 km2.Es un cuerpo intrusivo postcinemático de probable edad paleozoica. Las rocas encajantes son metamorfitas correspondientes al Prec

Fiscal 2000 basic survey report for vision formulation. Regional new energy vision for Sabae city, Fukui prefecture; Sabaeshi chiiki shin energy vision. 2000 nendo sakutei kiso chosa hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

Sabae city, Fukui Prefecture, has worked out a regional new energy vision for which the inhabitants, industrialists, and administrators combined their efforts to build a daily life related culture, friendly to environments and peculiar to the locality. The fruits of their activities are summarized in five chapters, which are (1) the basic philosophy, (2) survey of the amounts of new energy in existence, (3) survey of the amount of energy demanded, (4) various surveys conducted with the participation of the citizenry, (5) and summarization of important topics. Discussed in chapter (2) is the basic policy toward reckoning the amounts of new energy in existence, such as photovoltaic energy, solar heat energy, wind energy, hydraulic energy, temperature difference energy, and other energy resources remaining to be utilized. It states that they, when converted into electric power, 2.0 times 10{sup 8} kWh/year will be available and, when converted into heat energy, 2.92 times 10{sup 11} kcal/year will be available, accounting for approximately 30% of the city's energy consumption. When the energy resources are broken down by type, it is found that solar energy, wind energy, and refuse-derived energy are in existence aplenty. (NEDO)

Frequency of Helicobacter pylori blood-group antigen-binding adhesion 2 and sialic acid binding adhesion genes among dyspeptic patients in Tabriz, Iran

Directory of Open Access Journals (Sweden)

Leila Yousefi

2015-06-01

Full Text Available Introduction: The purpose of this research was to analyze blood-group antigen-binding adhesion (babA2 and sialic acid binding adhesion (sabA genotypes status in Helicobacter pylori (H. pylori isolates and their relationship with clinical outcomes. Methods: Gastric biopsy specimens were homogenized and placed in Brucella agar medium supplemented with 5% sheep blood and 3 antibiotics and were cultured at 37 °C under microaerophilic conditions and incubated for 4-7 days. H. pylori was identified by typical morphology, gram-staining and urease tests, and babA2 and sabA genes were detected by polymerase chain reaction (PCR. Results: From a total of 100 H. pylori isolates; babA2 and sabA genes were detected in 23.0 and 26.4%, respectively. There was a significant relationship between these genes and clinical outcomes (P < 0.050. Conclusion: We found that the babA2 status was not related to clinical outcomes in Tabriz, Iran. However, sabA was a promoting determinant for disease, and multivariate analysis disclosed sabA to be an independent marker of non-ulcer diseases in our subjects.

Involvement of Ca2+ Signaling in the Synergistic Effects between Muscarinic Receptor Antagonists and β2-Adrenoceptor Agonists in Airway Smooth Muscle

Directory of Open Access Journals (Sweden)

Kentaro Fukunaga

2016-09-01

Full Text Available Long-acting muscarinic antagonists (LAMAs and short-acting β2-adrenoceptor agonists (SABAs play important roles in remedy for COPD. To propel a translational research for development of bronchodilator therapy, synergistic effects between SABAs with LAMAs were examined focused on Ca2+ signaling using simultaneous records of isometric tension and F340/F380 in fura-2-loaded tracheal smooth muscle. Glycopyrronium (3 nM, a LAMA, modestly reduced methacholine (1 μM-induced contraction. When procaterol, salbutamol and SABAs were applied in the presence of glycopyrronium, relaxant effects of these SABAs are markedly enhanced, and percent inhibition of tension was much greater than the sum of those for each agent and those expected from the BI theory. In contrast, percent inhibition of F340/F380 was not greater than those values. Bisindolylmaleimide, an inhibitor of protein kinase C (PKC, significantly increased the relaxant effect of LAMA without reducing F340/F380. Iberiotoxin, an inhibitor of large-conductance Ca2+-activated K+ (KCa channels, significantly suppressed the effects of these combined agents with reducing F340/F380. In conclusion, combination of SABAs with LAMAs synergistically enhances inhibition of muscarinic contraction via decreasing both Ca2+ sensitization mediated by PKC and Ca2+ dynamics mediated by KCa channels. PKC and KCa channels may be molecular targets for cross talk between β2-adrenoceptors and muscarinic receptors.

Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma

DEFF Research Database (Denmark)

O'Byrne, Paul M; Bisgaard, Hans; Godard, Philippe P

2005-01-01

with as-needed bud/form would provide rapid symptom relief and simultaneous adjustment in antiinflammatory therapy, thereby reducing exacerbations. In this double-blind, randomized, parallel-group study, 2,760 patients with asthma aged 4-80 years (FEV1 60-100% predicted) received either terbutaline 0.4 mg...... as SABA with bud/form 80/4.5 microg twice a day (bud/form + SABA) or bud 320 microg twice a day (bud + SABA) or bud/form 80/4.5 microg twice a day with 80/4.5 microg as-needed (bud/form maintenance + relief). Children used a once-nocte maintenance dose. Bud/form maintenance + relief prolonged time...... to first severe exacerbation (p relief also prolonged...

Does pre-hospital telephone communication with a clinician result in more appropriate medication administration by parents during childhood asthma exacerbations?

Science.gov (United States)

Garro, A C; Fearon, D; Koinis-Mitchell, D; McQuaid, E L

2009-11-01

The National Heart, Lung and Blood Institute asthma guidelines recommend that parents communicate with a clinician during childhood asthma exacerbations when symptoms worsen or do not improve with initial therapy. This study tested the hypothesis that communication by parents with a clinician before an Emergency Department visit was associated with more appropriate medication administration for children with asthma exacerbations. This was a retrospective cohort study using data gathered from parents of children presenting with an asthma exacerbation to the emergency department. The communicating cohort included parents who communicated by telephone with a clinician during the exacerbation and the non-communicating cohort included parents who did not. Multivariate logistic regression models were used to test three hypotheses; communication with a clinician is associated with (1) administration of short-acting beta-agonists (SABAs), (2) increased dosing frequency of SABAs, and (3) administration of an oral corticosteroid. A total of 199 subjects were enrolled, with 104 (52.3%) in the communicating and 95 (47.7%) in the non-communicating cohort. There was an association between communication and provider practice type, with children who received routine care from a private practice provider more likely to communicate with the clinician than children in hospital-based clinics or community health centers (Adjusted OR 1.9, 95% CI 1.0-3.7). Impoverished children and children insured by Medicaid were less likely to communicate with a clinician (controlling for provider type). Parents who communicated with a clinician were more likely to administer a SABA (adjusted OR 3.6, 95% CI 1.3-9.4) and an oral corticosteroid (adjusted OR 3.3, 95% CI 1.3-8.4) but were not more likely to administer a SABA with increased dosing frequency (adjusted OR 0.9, 95% CI 0.5-1.6). Parents of children with asthma exacerbations who communicated with clinicians were more likely to administer SABAs

The use of electronic alerts in primary care computer systems to identify the excessive prescription of short-acting beta2-agonists for people with asthma: a systematic review.

Science.gov (United States)

McKibben, Shauna; De Simoni, Anna; Bush, Andy; Thomas, Mike; Griffiths, Chris

2018-04-16

Computers are increasingly used to improve prescribing decisions in the management of long-term conditions however the effects on asthma prescribing remain unclear. We aimed to synthesise the evidence for the use of computerised alerts that identify excessive prescribing of short-acting beta 2 -agonists (SABAs) to improve asthma management for people with asthma. MEDLINE, CINAHL, Embase, Cochrane and Scopus databases (1990-2016) were searched for randomised controlled trials using electronic alerts to identify excessive prescribing of SABAs for people with asthma in primary care. Inclusion eligibility, quality appraisal (Cochrane risk of bias tool) and data extraction were performed by two independent reviewers. Findings were synthesised narratively. A total of 2035 articles were screened and four trials were eligible. Three studies had low risk of bias: one reported a positive effect on our primary outcome of interest, excessive SABA prescribing; another reported positive effects on the ratio of inhaled corticosteroid (ICS)-SABA prescribing, and asthma control; a third reported no effect on outcomes of interest. One study at high risk of bias reported a reduction in exacerbations and primary care consultations. There is some evidence that electronic alerts reduce excessive prescribing of SABAs, when delivered as part of a multicomponent intervention in an integrated health care system. However due to the variation in health care systems, intervention design and outcomes measured, further research is required to establish optimal design of alerting and intervening systems.

Women Fellows of INAE | Women in Science | Initiatives | Indian ...

Indian Academy of Sciences (India)

Women Fellows of INAE. INAE - Indian National Academy of Engineering. Ms. Alpa Sheth Civil Engineering. Prof. Bharathi Bhat Electronics & Communication Engineering. Prof. Dipanwita Roy Chowdhury Computer Engineering and Information Technology. Prof. Kamala Krithivasan Computer Engineering and Information ...

78 FR 1101 - Hazardous Materials: Harmonization With the United Nations Recommendations on the Transport of...

Science.gov (United States)

2013-01-07

..., S.A. (Amadeus). Air Line Pilots Association International (ALPA). Airlines for America (A4A). Alaska Airlines (Alaska). American Coatings Association (ACA). American Veterinary Distributors Association (AVDA... Transportation of Hazardous Articles, Inc. (COSTHA). Dangerous Goods Advisory Council, Inc. (DGAC). Food...

Effect of a mobile health, sensor-driven asthma management platform on asthma control.

Science.gov (United States)

Barrett, Meredith A; Humblet, Olivier; Marcus, Justine E; Henderson, Kelly; Smith, Ted; Eid, Nemr; Sublett, J Wesley; Renda, Andrew; Nesbitt, LaQuandra; Van Sickle, David; Stempel, David; Sublett, James L

2017-11-01

Asthma inflicts a significant health and economic burden in the United States. Self-management approaches to monitoring and treatment can be burdensome for patients. To assess the effect of a digital health management program on asthma outcomes. Residents of Louisville, Kentucky, with asthma were enrolled in a single-arm pilot study. Participants received electronic inhaler sensors that tracked the time, frequency, and location of short-acting β-agonist (SABA) use. After a 30-day baseline period during which reference medication use was recorded by the sensors, participants received access to a digital health intervention designed to enhance self-management. Changes in outcomes, including mean daily SABA use, symptom-free days, and asthma control status, were compared among the initial 30-day baseline period and all subsequent months of the intervention using mixed-model logistic regressions and χ 2 tests. The mean number of SABA events per participant per day was 0.44 during the control period and 0.27 after the first month of the intervention, a 39% reduction. The percentage of symptom-free days was 77% during the baseline period and 86% after the first month, a 12% improvement. Improvement was observed throughout the study; each intervention month demonstrated significantly lower SABA use and higher symptom-free days than the baseline month (P asthma during the baseline period, 67% during the first month of the intervention. Each intervention month demonstrated significantly higher percentages than the baseline month (P asthma management intervention demonstrated significant reductions in SABA use, increased number of symptom-free days, and improvements in asthma control. ClinicalTrials.gov Identifier: NCT02162576. Copyright © 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

75 FR 27416 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702...

Science.gov (United States)

2010-05-17

... (ALPA) supports the proposed AD. Request To Delay Rule Until Updated Service Information Is Released... rule. SUMMARY: We are adopting a new airworthiness directive (AD) for the products listed above. This... not agree that it is necessary to wait to issue this final rule until the manufacturer updates...

Different control mechanisms regulate glucoamylase and protease gene transcription in Aspergillus oryzae in solid-state and submerged fermentation

NARCIS (Netherlands)

Biesebeke, R. te; Biezen, N. van; Vos, W.M. de; Hondel, C.A.M.J.J. van den; Punt, P.J.

2005-01-01

Solid-state fermentation (SSF) with Aspergillus oryzae results in high levels of secreted protein. However, control mechanisms of gene expression in SSF have been only poorly studied. In this study we show that both glucoamylase (glaB) and protease (alpA, nptB) genes are highly expressed during

Microcontroller based automatic liquid poison addition control system

International Nuclear Information System (INIS)

Kapatral, R.S.; Ananthakrishnan, T.S.; Pansare, M.G.

1989-01-01

Microcontrollers are finding increasing applications in instrumentation where complex digital circuits can be substituted by a compact and simple circuit, thus enhancing the reliability. In addition to this, intelligence and flexibility can be incorporated. For applications not requiring large amount of read/write memory (RAM), microcontrollers are ideally suited since they contain programmable memory (Eprom), parallel input/output lines, data memory, programmable timers and serial interface ports in one chip. This paper describes the design of automatic liquid poison addition control system (ALPAS) using intel's 8 bit microcontroller 8751, which is used to generate complex timing control sequence signals for liquid poison addition to the moderator in a nuclear reactor. ALPAS monitors digital inputs coming from protection system and regulating system of a nuclear reactor and provides control signals for liquid poison addition for long term safe shutdown of the reactor after reactor trip and helps the regulating system to reduce the power of the reactor during operation. Special hardware and software features have been incorporated to improve performance and fault detection. (author)

Summary Report on NRL Participation in the Microwave Landing System Program.

Science.gov (United States)

1980-08-19

shifters were measured and statistically analyzed. Several research contracts for promising phased array techniques were awarded to industrial contractors...program was written for compiling statistical data on the measurements, which reads out inser- sertion phase characteristics and standard deviation...GLOSSARY OF TERMS ALPA Airline Pilots’ Association ATA Air Transport Association AWA Australiasian Wireless Amalgamated AWOP All-weather Operations

Operational Problems Associated with Head-Up Displays during Instrument Flight.

Science.gov (United States)

1980-10-01

Force project engineers were Major Michael F. Rundle and Mr. William L. Welde . 41 4 TABLE OF CONTENTS Page ABBREVIATIONS...of Automotive Engineers SETP Society of Experimental Test Pilots SI Solid Instruments SNPL Syndicat National des Pilotes des Lignes (French ALPA) TACAN...Factors Relevent to Jet Upsets ," Lessons with Emphasis on Flight Mechanics from Operating Experience, Incidents, and Accidents, AGARD CP-76, 1971 153 J

Assessing the association between omalizumab and arteriothrombotic events through spontaneous adverse event reporting.

Science.gov (United States)

Ali, Ayad K; Hartzema, Abraham G

2012-01-01

Omalizumab is a monoclonal antibody, indicated for the treatment of severe allergic asthma. In Europe, there have been concerns about the cardiovascular safety of omalizumab. The objective of this study was to analyze the association between omalizumab and arterial thrombotic events in a spontaneous adverse drug reaction reporting database in the US. Reports of arterial thrombotic events submitted to the US Food and Drug Administration's Adverse Event Reporting System (AERS) between 2004 and 2011 were retrieved and analyzed by the reporting odds ratio data mining algorithm. The reporting odds ratio of arterial thrombotic events for omalizumab was compared with specific asthma medications and all drugs in the AERS. Values ≥2 were considered significant safety signals. The Medical Dictionary for Regulatory Activities Preferred Terms were used to identify arterial thrombotic events (eg, stroke, myocardial infarction). In total, 293,783 reports of arterial thrombotic events were retrieved (about 2% of all adverse drug reaction reports), corresponding to 2274 asthma drug-arterial thrombotic events pairs (omalizumab, 222; inhaled corticosteroids [ICS], 131; long-acting beta-agonists [LABA], 102; single-device combination ICS-LABA, 506; inhaled short-acting beta-agonists [SABA], 475; oral SABA, 6; inhaled antimuscarinics [AMC], 477; single-device combination AMC-SABA, 127; xanthines, 50; leukotriene modifiers, 174; and mast cell stabilizers, 4). Reporting odds ratio and 95% confidence interval values for omalizumab compared with other asthma drugs and all drugs in AERS were 2.75 (2.39-316) and 1.09 (0.95-1.24), respectively. Omalizumab ranked second after ICS in the risk of arterial thrombotic events, followed by AMC, AMC-SABA, and ICS-LABA. Omalizumab is associated with higher than expected reporting of arterial thrombotic events in asthmatic patients. This hypothesis needs further testing in robust epidemiological studies.

Superconducting tunnel-junction refrigerator

International Nuclear Information System (INIS)

Melton, R.G.; Paterson, J.L.; Kaplan, S.B.

1980-01-01

The dc current through an S 1 -S 2 tunnel junction, with Δ 2 greater than Δ 1 , when biased with eV 1 +Δ 2 , will lower the energy in S 1 . This energy reduction will be shared by the phonons and electrons. This device is shown to be analogous to a thermoelectric refrigerator with an effective Peltier coefficient π* approx. Δ 1 /e. Tunneling calculations yield the cooling power P/sub c/, the electrical power P/sub e/ supplied by the bias supply, and the cooling efficiency eta=P/sub c//P/sub e/. The maximum cooling power is obtained for eV= +- (Δ 2 -Δ 1 ) and t 1 =T 1 /T/sub c/1 approx. 0.9. Estimates are made of the temperature difference T 2 -T 1 achievable in Al-Pb and Sn-Pb junctions with an Al 2 O 3 tunneling barrier. The performance of this device is shown to yield a maximum cooling efficiency eta approx. = Δ 1 /(Δ 2 -Δ 1 ) which can be compared with that available in an ideal Carnot refrigerator of eta=T 1 /(T 2 -T 1 ). The development of a useful tunnel-junction refrigerator requires a tunneling barrier with an effective thermal conductance per unit area several orders of magnitude less than that provided by the A1 2 O 3 barrier in the Al-Pb and Sn-Pb systems

8 CFR 286.1 - Definitions.

Science.gov (United States)

2010-01-01

..., Marie-Galante, Martinique, Miquelon, Montserrat, Saba, Saint Barthélemy, Saint Christopher, Saint Eustatius, Saint Kitts-Nevis, Saint Lucia, Saint Maarten, Saint Martin, Saint Pierre, Saint Vincent and...

Assessment of spirometry and impulse oscillometry in relation to asthma control.

Science.gov (United States)

Manoharan, Arvind; Anderson, William J; Lipworth, Joseph; Lipworth, Brian J

2015-02-01

Guidelines advocate the use of spirometry to assess pulmonary function in asthmatic patients. Commonly used measures include forced expiratory volume in 1 s (FEV1), forced expiratory ratio (FEV1/FVC), and forced mid-expiratory flow between 25 and 75 % of forced vital capacity (FEF25-75). Impulse oscillometry (IOS) is an effort-independent test performed during tidal breathing. IOS may be used to assess the total and central airway resistance at 5 Hz (R5) and 20 Hz (R20), respectively, and hence derive the peripheral airway resistance from the difference (R5-R20). We compared spirometry and IOS as tests of global airway function (i.e., FEV1, FEV1/FVC, R5) and putative measures of small airways function (i.e., FEF25-75, R5-R20) and their relationship to oral steroid and short-acting beta-agonist (SABA) use as surrogates for long-term asthma control. Spirometry and IOS measurements from physician-diagnosed asthmatics were linked to a health informatics database for oral steroid and SABA use 1 year prior to the index measurements. Four hundred forty-two patients had both spirometry and IOS, mean FEV1 = 86 % predicted, 94 % on ICS, median dose 800 µg/day. IOS and spirometry measures were equally predictive of impaired asthma control for both oral steroid and SABA use. For oral steroid use, the adjusted odds ratio, OR (95 % CI) is as follows: FEV1 150 %: 1.91(1.25-2.95), p = 0.003; and R5-R20 > 0.1 kPa L(-1) s 1.73(1.12-2.66), p = 0.013. For SABA use, the adjusted OR (95 % CI) is as follows: FEV1 150 %: 1.76(1.18-2.63), p = 0.006; and R5-R20 > 0.1 kPa L(-1) s: 2.94(1.94-4.46), p Spirometry or IOS measurements were equally useful as potential markers of asthma control in persistent asthmatic patients.

Assessing the association between omalizumab and arteriothrombotic events through spontaneous adverse event reporting

Directory of Open Access Journals (Sweden)

Ali AK

2012-05-01

Full Text Available Ayad K Ali, Abraham G HartzemaDepartment of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, USABackground: Omalizumab is a monoclonal antibody, indicated for the treatment of severe allergic asthma. In Europe, there have been concerns about the cardiovascular safety of omalizumab. The objective of this study was to analyze the association between omalizumab and arterial thrombotic events in a spontaneous adverse drug reaction reporting database in the US.Methods and materials: Reports of arterial thrombotic events submitted to the US Food and Drug Administration's Adverse Event Reporting System (AERS between 2004 and 2011 were retrieved and analyzed by the reporting odds ratio data mining algorithm. The reporting odds ratio of arterial thrombotic events for omalizumab was compared with specific asthma medications and all drugs in the AERS. Values ≥2 were considered significant safety signals. The Medical Dictionary for Regulatory Activities Preferred Terms were used to identify arterial thrombotic events (eg, stroke, myocardial infarction.Results: In total, 293,783 reports of arterial thrombotic events were retrieved (about 2% of all adverse drug reaction reports, corresponding to 2274 asthma drug-arterial thrombotic events pairs (omalizumab, 222; inhaled corticosteroids [ICS], 131; long-acting beta-agonists [LABA], 102; single-device combination ICS-LABA, 506; inhaled short-acting beta-agonists [SABA], 475; oral SABA, 6; inhaled antimuscarinics [AMC], 477; single-device combination AMC-SABA, 127; xanthines, 50; leukotriene modifiers, 174; and mast cell stabilizers, 4. Reporting odds ratio and 95% confidence interval values for omalizumab compared with other asthma drugs and all drugs in AERS were 2.75 (2.39–316 and 1.09 (0.95–1.24, respectively. Omalizumab ranked second after ICS in the risk of arterial thrombotic events, followed by AMC, AMC-SABA, and ICS-LABA.Conclusion: Omalizumab is

American Public Health Association

Science.gov (United States)

... like Saba are about three to four times… https://www.nytimes.com/2017/11/13/health/colombia- ... often be overlooked as a cause of death": https://insideclimatenews.… Environmental health matters: https://www.theatlantic.com/ ...

Many-Body Potentials For Binary Immiscible liquid Metal Alloys

International Nuclear Information System (INIS)

Karaguelle, H.

2004-01-01

The modified analytic embedded atom method (MAEAM) type many- body potentials have been constructed for three binary liquid immiscible alloy systems: Al-Pb, Ag-Ni, Ag- Cu. The MAEAM potential functions are fitted to both solid and liquid state properties for only liquid pure metals which consist the immiscible alloy. In order to test the reliability of the constructed MAEAM effective potentials, partial structure factors and pair distribution functions of these binary liquid metal alloys have been calculated using the thermodynamically self-consistent variational modified hypernetted chain (VMHNC) theory of liquids. A good agreement with the available experimental data for structure has

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

PS1 mouse model of Alzheimer's disease · VIVEK TIWARI KAMAL SABA PANDICHELVAM VEERAIAH JEDY JOSE SUBHASH C LAKHOTIA ANANT B PATEL · More Details Abstract Fulltext PDF. Alzheimer's disease (AD) is the most common ...

Out of time : the limits of secular critique

Directory of Open Access Journals (Sweden)

Randell-Moon, Holly

2011-01-01

Full Text Available A review of Talal Asad, Wendy Brown, Judith Butler, Saba Mahmood, 'Is critique secular? Blasphemy, injury, and free speech' and Michael Warner, Jonathan Vanantwerpen, and Craig Calhoun (eds, 'Varieties of secularism in a secular age'.

Budesonide/formoterol maintenance and reliever therapy versus conventional best practice

DEFF Research Database (Denmark)

Demoly, Pascal; Louis, Renaud; Søes-Petersen, Ulrik

2009-01-01

Budesonide/formoterol maintenance and reliever therapy (Symbicort SMART) reduces asthma exacerbations and symptoms versus fixed-dose regimens plus short-acting beta(2)-agonists (SABA) in double-blind trials. Information is lacking regarding its effectiveness versus conventional best practice (CBP...

Effets de la microdose sur la production du niébé, du mil et du ...

African Journals Online (AJOL)

Effets de la microdose sur la production du niébé, du mil et du sorgho en fonction la toposéquence. Fatimata Saba, Sibiri Jean Baptiste Taonda, Idriss Serme, Alimata A. Bandaogo, Augustin P. Sourwema, Adama Kabre ...

Administrative claims analysis of asthma-related health care utilization for patients who received inhaled corticosteroids with either montelukast or salmeterol as combination therapy.

Science.gov (United States)

Allen-Ramey, Felicia C; Bukstein, Don; Luskin, Allan; Sajjan, Shiva G; Markson, Leona E

2006-05-01

To compare asthma-related health care resource utilization among a matched cohort of asthma patients using inhaled corticosteroids (ICSs) plus either montelukast (MON) or salmeterol (SAL) as combination therapy for asthma, during a time prior to the availability of fixed-dose combinations of ICS/SAL. A retrospective analysis using the PHARMetrics patient-centric claims database was conducted for the period preceding the market introduction of combination fluticasone-SAL in September 2000. Patients had to meet the following criteria for inclusion in the study: they had to be between the ages of 4 and 55 years; they had to have been continuously enrolled for 2 years; they had to have initiated ICS/MON or ICS/SAL therapy between July 1, 1998, and June 30, 1999; and they had to have had either (a) a diagnosis of asthma (based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes of 493.xx) for 2 outpatient visits, 1 or more emergency department (ED) visits, or 1 or more hospitalizations within 1 year or (b) pharmacy claim records that contained a National Drug Code for an antiasthma medication (betaagonist, theophylline, ICS, cromolyn, or leukotriene) 2 or more times within 1 year. ICS/MON and ICS/SAL patients were matched 1 to 1 on age and propensity score. Outcomes included asthma-related hopitalizations and ED visits with ICD-9-CM codes of 493.xx, and oral corticosteroid (OCS) fills and short-acting beta-agonist (SABA) fills. Multivariate regression analyses were performed. Subgroup analyses based on sequential or concurrent initiation of combination therapy were also conducted. A total of 1,216 patients were matched (ICS/MON = 608; ICS/SAL= 608). Decreased odds of ED visits and/or hospitalizations were observed with ICS/MON (adjusted odds ratio [OR] = 0.58; 95% confidence interval [CI], 0.35- 0.98) versus ICS/SAL. The odds of postindex OCS fills were not different for ICS/MON and ICS/SAL patients (adjusted OR = 1.04; 95

Muslim women in the western media: Foucault, agency, governmentality and ethics

NARCIS (Netherlands)

Vintges, K.

2012-01-01

This article compares the ways in which Saba Mahmood’s The Politics of Piety (2005) and Cressida Heyes’ Self-Transformations: Foucault, Ethics, and Normalization (2007), unlike current governmentality studies, employ the later Foucault’s ethical theory. By explaining the theoretical framework of the

Towards better treatment outcomes in childhood asthma

NARCIS (Netherlands)

Koster, E.S.

2011-01-01

Standard treatment for peadiatric asthmatics is based on regular use of inhaled corticosteroids (ICS) combined with short-acting beta-agonists (SABA). Despite the effectiveness of this standard treatment strategy in most patients, there is large variability in treatment response. Many factors can

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Pd immobilized on modified magnetic Fe₃O₄ nanoparticles: Magnetically recoverable and reusable Pd nanocatalyst for Suzuki-Miyaura coupling reactions and Ullmann-type N-arylation of indoles. RAMIN GHORBANI-VAGHEI SABA HEMMATI MALAK HEKMATI. Regular Article Volume 128 Issue 7 July 2016 pp 1157- ...

The potential for dive tourism led entrepreneurial marine protected areas in Curacao

NARCIS (Netherlands)

Groot, de J.; Bush, S.R.

2010-01-01

Despite the successful establishment of marine protected areas in the Netherlands Antilles, such as Saba and Bonaire, government-led protection of the reefs surrounding Curacao has repeatedly failed. In the absence of effective state regulation, dive operations have taken de facto control over dive

Indicators on the status and trends of ecosystems in the Dutch Caribbean

NARCIS (Netherlands)

Verweij, P.J.F.M.; Meesters, H.W.G.; Debrot, A.O.

2015-01-01

The Caribbean islands of Bonaire, Saba, St.Eustatius, Aruba, Curacao and St. Maarten are part of the Kingdom of the Netherlands. The islands have a rich biological diversity and a variety of globally threatened ecosystems. These ecosystems are important for their services such as the production of

Gestion des forêts domaniales en période de conflits : cas de la forêt ...

African Journals Online (AJOL)

Gestion des forêts domaniales en période de conflits : cas de la forêt classée du Haut-Sassandra, Centre-Ouest de la Côte d'Ivoire. Akoua Tamia Madeleine Kouakou, Yao Sadaiou Sabas Barima, Souleymane Konate, Issouf Bamba, Justin Yatty Kouadio, Jan Bogaert ...

The Caribbean Netherlands, five years after the transition

NARCIS (Netherlands)

Evert Pommer; Rob Bijl .

2015-01-01

Original title: Vijf jaar Caribisch Nederland On 10 October 2010 the islands of Bonaire, Sint Eustatius and Saba, under the flag of the Caribbean Netherlands, acquired the status of new Dutch public bodies, as part of the Netherlands. This transition marked the end of the Netherlands Antilles as

Climate change effects on the biodiversity of the BES islands : assessment of the possible consequences for the marine and terrestrial ecosystems of the Dutch Antilles and the options for adaptation measures

NARCIS (Netherlands)

Debrot, A.O.; Bugter, R.J.F.

2010-01-01

Due to their vulnerability and low capacity to adapt, the impact of climate change on small island nations will be far larger compared to larger countries. The Dutch BES islands (Bonaire, St. Eustatius and Saba) form part of the Caribbean global biodiversity hotspot area. The leeward Dutch islands

Mosquitoes of the Netherlands Antilles and their hygienic importance

NARCIS (Netherlands)

Kuyp, van der Edwin

1954-01-01

The Netherlands Antilles may be divided into: (1) The Curaçao Group (or Netherlands Leeward Islands): Curaçao, Aruba and Bonaire. (2) The St. Martin Group (or Netherlands Windward Islands): (Netherlands) St. Maarten, Saba and St. Eustatius. The latter islands are very small, forming together only

Observations on the whale shark (Rhincodon typus) in the Dutch Caribbean

NARCIS (Netherlands)

Debrot, A.O.; Leon, R.; Esteban, N.; Meesters, H.W.G.

2013-01-01

Records of whale sharks in the Caribbean are relatively sparse. Here we document 24 records of whale sharks (Rhincodon typus Smith 1882) for the Dutch Caribbean, four for the windward islands of Saba, St. Eustatius and St. Maarten, and twenty for the southern Caribbean leeward islands of Aruba,

The Heteroptera of the Netherlands Antilles – V Tingidae (Lace Bugs)

NARCIS (Netherlands)

Drake, Carl J.; Cobben, R.H.

1960-01-01

The present paper is based upon the lace bugs, Family Tingidae, collected by the junior author in the West Indies, on the islands of Aruba, Curaçao, Bonaire, St. Martin, Saba, and St. Eustatius. This collection of several tingids comprises 17 species, including the five new forms described below.

A repetitive DNA element regulates expression of the Helicobacter pylori sialic acid binding adhesin by a rheostat-like mechanism.

Directory of Open Access Journals (Sweden)

Anna Åberg

2014-07-01

Full Text Available During persistent infection, optimal expression of bacterial factors is required to match the ever-changing host environment. The gastric pathogen Helicobacter pylori has a large set of simple sequence repeats (SSR, which constitute contingency loci. Through a slipped strand mispairing mechanism, the SSRs generate heterogeneous populations that facilitate adaptation. Here, we present a model that explains, in molecular terms, how an intergenically located T-tract, via slipped strand mispairing, operates with a rheostat-like function, to fine-tune activity of the promoter that drives expression of the sialic acid binding adhesin, SabA. Using T-tract variants, in an isogenic strain background, we show that the length of the T-tract generates multiphasic output from the sabA promoter. Consequently, this alters the H. pylori binding to sialyl-Lewis x receptors on gastric mucosa. Fragment length analysis of post-infection isolated clones shows that the T-tract length is a highly variable feature in H. pylori. This mirrors the host-pathogen interplay, where the bacterium generates a set of clones from which the best-fit phenotypes are selected in the host. In silico and functional in vitro analyzes revealed that the length of the T-tract affects the local DNA structure and thereby binding of the RNA polymerase, through shifting of the axial alignment between the core promoter and UP-like elements. We identified additional genes in H. pylori, with T- or A-tracts positioned similar to that of sabA, and show that variations in the tract length likewise acted as rheostats to modulate cognate promoter output. Thus, we propose that this generally applicable mechanism, mediated by promoter-proximal SSRs, provides an alternative mechanism for transcriptional regulation in bacteria, such as H. pylori, which possesses a limited repertoire of classical trans-acting regulatory factors.

Human rights versus societal norms: a mixed methods study among healthcare providers on social stigma related to adolescent abortion and contraceptive use in Kisumu, Kenya.

Science.gov (United States)

Håkansson, Miranda; Oguttu, Monica; Gemzell-Danielsson, Kristina; Makenzius, Marlene

2018-01-01

Adolescent pregnancy represents a serious public health issue in sub-Saharan Africa, and stigmatising attitudes are contributing factors. This study investigates stigmatising attitudes related to adolescent pregnancy, abortion and contraceptive use among healthcare providers working with postabortion care (PAC) in a low-resource setting in Kenya. A mixed methods approach in a convergent design was utilised to capture attitudes related to abortion and contraceptive use among 86 (f=62; m=19) PAC providers in Kisumu, Kenya. Two Likert-scale questionnaires were used: the 18-item Stigmatising Attitudes, Beliefs and Actions Scale (SABAS) and the 7-item Contraceptive Use Stigma Scale (CUSS). 74 PAC providers responded to the SABAS, 44 to the CUSS and 12 participated in two focus group discussions. Descriptive statistics, psychometric tests of instruments and qualitative content analysis were conducted and reported in accordance with Consolidated Criteria for Reporting Qualitative Research. Cronbach's α coefficients for the total instrument was 0.88 (SABAS) and 0.84 (CUSS). The majority, 92% (68/74) agreed that a woman who has had an abortion should be treated equally to everyone else, 27% (20/74) considered abortion a sin and 30% (22/74) believed she will make abortion a habit. Contraceptive use among adolescent women was associated with promiscuity (39%; 17/44), hence contraceptives should only be available to married women (36%; 16/44), and 20% (9/44) believed that contraceptive use causes infertility. The providers encouraged women's autonomy and their rights to sexual and reproductive health; however, unclear regulations reinforce religious and cultural beliefs, which hampers implementation of evidence-based contraceptive counselling. Stigmatising attitudes towards young women in need of abortion and contraception is common among PAC providers. Their work is characterised by a conflict between human rights and societal norms, thus highlighting the need for

tant sorghum grain as energy source in fattening diets for beef steers

African Journals Online (AJOL)

FORD, J.E., 1977. Availability of methionine and lysine in sorghum grain in relation to the tannin content. Proc. Nutr. Soc. 36, 124A. HALE, W.H. & PROUTY, F.L., 1980.Current status of grain process- ing: Efficiency of processing systems. Proc. 8th Annual Texas Beef. Conj., Amarillo, Texas. HALE, W.H., TAYLOR, B., SABA, ...

Browse Title Index

African Journals Online (AJOL)

Items 301 - 350 of 643 ... Vol 7, No 3 (2004), glycemic control and pain threshold in alloxan diabetic rats, Abstract PDF. GF Ibironke, OJ Saba, FO Olopade ... Vol 7, No 3 (2004), Heavy metal contamination of Clarias gariepinus from a lake and fish farm in Ibadan, Nigeria, Abstract PDF. FE Olaifa, AK Olaifa, AA Adelaja, AG ...

SABA: A Testbed for a Real-Time MIMO System

Directory of Open Access Journals (Sweden)

Brühl Lars

2006-01-01

Full Text Available The growing demand for high data rates for wireless communication systems leads to the development of new technologies to increase the channel capacity thus increasing the data rate. MIMO (multiple-input multiple-output systems are best qualified for these applications. In this paper, we present a MIMO test environment for high data rate transmissions in frequency-selective environments. An overview of the testbed is given, including the analyzed algorithms, the digital signal processing with a new highly parallel processor to perform the algorithms in real time, as well as the analog front-ends. A brief overview of the influence of polarization on the channel capacity is given as well.

Internal friction in Al alloys after neutron irradiation at low temperature

International Nuclear Information System (INIS)

Takamura, S.; Kobiyama, M.

1985-01-01

Internal friction and elastic modulus of dilute Al alloys have been measured after fast neutron irradiation at about 5 K. The internal friction spectra in Al-Pb, Al-Si, Al-Zn, Al-Ag, Al-Sn and Al-In are very similar. This result suggests that the configuration of the interstitial-solute atom complex in these alloys is very similar. In Al-Mg, the main complexes have the configuration with nearly symmetry, but its internal friction spectrum is different from that of the above-mentioned alloys. The internal friction spectra and their annealing behavior in Al-Be, Al-Mn, Al-Fe and Al-Cu demonstrate that the configuration of their interstitial-solute atom complex seems to be different from each other and the main complex in these alloys is immobile until stage III. (author)

Asthma prescribing practices of government and private doctors in Malaysia--a nationwide questionnaire survey.

Science.gov (United States)

Loh, Li-Cher; Wong, Pel-Se

2005-03-01

A self-answered, anonymously completed questionnaire survey was performed between June 2002 and May 2003 where doctors from government and private sectors in Malaysia were invited to participate by post or during medical meetings. One hundred and sixteen government doctors and 110 private doctors provided satisfactorily completed questionnaires (effective respondent rate: 30.1%). The most preferred medications for 'first-line', 'second-line' and 'third-line' treatment were for government doctors: inhaled short-acting beta2-agonist (SABA) (98%), inhaled corticosteroids (CS) (75%), and leukotriene antagonist (52%); and for private doctors: oral SABA (81%), inhaled CS (68%), and oral CS (58%). The first choice inhaler device for most government and private doctors were metered dose inhalers, with cost and personal preferences (for private doctors), and technical ability (for government doctors) as the key considerations when deciding on the choice of device. This benchmark data on the asthma prescribing practices of a healthcare delivery system fully dichotomized into government and private sector, provides evidence for practice differences affected by the nature of the healthcare system, and might have implications on healthcare systems of other countries that share similarities with that of Malaysia.

The Slavonic Translation of the Life of Saint Euthymius the Great: Observations on Language and Authorship

Directory of Open Access Journals (Sweden)

Dmitriy Evgenyevich Afinogenov

2015-10-01

Full Text Available The Slavonic translation of the Life of Saint Euthymius the Great (BHG 647 by Cyril of Scythopolis, attested at the earliest manuscript of the late 14th c., was probably made by a person originating from South-East Rus in the 11th c., as it displays some grammatical, lexical, and phonetic features peculiar for this area and time, and visible, in particular, in Ipatiev Chronicle and the Tale of Igor’s Campaign. It may have formed a part of the collection comprising several writings by Cyril, including the Life of Saint Sabas and the Praise of Euthymius and Sabas (lost in the Greek original. This collection was later incorporated into the Great Lectionary Menologion of Metropolitan Makarij. The details added by the translator to the description of certain realia pertaining to the Monastery of Saint Euthymius in Palestine suggest a personal knowledge of that monastic complex (the Laura and the coenobium. The proposed author of the translation is Saint Anthony of the Cave Monastery in Kiev († 1073, who could perfectly well have visited the Holy Land during his stay on Mount Athos prior to 1051.

Medium and large mammals in the Sierra La Madera, Sonora, Mexico

Science.gov (United States)

Erick Oswaldo Bermudez-Enriquez; Rosa Elena Jimenez-Maldonado; Gertrudis Yanes-Arvayo; Maria de la Paz Montanez-Armenta; Hugo Silva-Kurumiya

2013-01-01

Sierra La Madera is a Sky Island mountain range in the Madrean Archipelago. It is in Fracción V of the Ajos-Bavispe CONANP Reserve in the Municipios (= Counties) of Cumpas, Granados, Huásabas, Moctezuma, and Villa Hidalgo. Medium and large mammals were inventoried using camera traps. Eighteen Wild View 2® camera traps were deployed during four sampling periods: August...

Molecular and Morphological Species Boundaries in the Gorgonian Octocoral Genus Pterogorgia (Octocorallia: Gorgoniidae.

Directory of Open Access Journals (Sweden)

Herman H Wirshing

Full Text Available Most gorgonian octocoral species are described using diagnostic characteristics of their sclerites (microscopic skeletal components. Species in the genus Pterogorgia, however, are separated primarily by differences in their calyx and branch morphology. Specimens of a morphologically unusual Pterogorgia collected from Saba Bank in the NE Caribbean Sea were found with calyx morphology similar to P. citrina and branch morphology similar to P. guadalupensis. In order to test morphological species boundaries, and the validity of calyx and branch morphology as systematic characters, a phylogenetic analysis was undertaken utilizing partial gene fragments of three mitochondrial (mtMutS, cytochrome b, and igr4; 726bp total and two nuclear (ITS2, 166bp; and SRP54 intron, 143bp loci. The datasets for nuclear and mitochondrial loci contained few phylogenetically informative sites, and tree topologies did not resolve any of the morphological species as monophyletic groups. Instead, the mitochondrial loci and SRP54 each recovered two clades but were slightly incongruent, with a few individuals of P. guadalupensis represented in both clades with SRP54. A concatenated dataset of these loci grouped all P. anceps and P. guadalupensis in a clade, and P. citrina and the Pterogorgia sp. from Saba Bank in a sister clade, but with minimal variation/resolution within each clade. However, in common with other octocoral taxa, the limited genetic variation may not have been able to resolve whether branch variation represents intraspecific variation or separate species. Therefore, these results suggest that there are at least two phylogenetic lineages of Pterogorgia at the species level, and the atypical Pterogorgia sp. may represent an unusual morphotype of P. citrina, possibly endemic to Saba Bank. Branch morphology does not appear to be a reliable morphological character to differentiate Pterogorgia species (e.g., branches "flat" or "3-4 edges" in P. guadalupensis and P

Efficacy and Safety of Anti-Interleukin-5 Therapy in Patients with Asthma: A Systematic Review and Meta-Analysis.

Directory of Open Access Journals (Sweden)

Fa-Ping Wang

Full Text Available Recent trials have assessed the efficacy and safety of novel monoclonal antibodies such as reslizumab and benralizumab. However, the overall efficacy and safety anti-interleukin (IL 5 treatment in asthma have not been thoroughly assessed.Randomized controlled trials (RCTs of anti-IL-5 treatment on patients with asthma published up to October 2016 in PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL that reported pulmonary function, quality of life scores, asthmatic exacerbation rate, blood and sputum eosinophil counts, short-acting β-agonist (SABA rescue use, and adverse events were included. The pooled mean difference, and relative risks (RR, and 95% confidence intervals (CIs were calculated using random-effects models.Twenty studies involving 7100 patients were identified. Pooled analysis revealed significant improvements in FEV1 (first second forced expiratory volume (MD = 0.09, 95% CI: 0.06-0.12, I2 = 10%, FEV1% (MD = 3.75, 95% CI: 1.66-5.83, I2 = 19%, Asthma Quality of Life Questionnaire (AQLQ score (MD = 0.22, 95% CI: 0.15-0.30, I2 = 0%, decreased blood, sputum eosinophils and asthmatic exacerbation (RR = 0.66, 95% CI: 0.59-0.73, I2 = 51%; peak expiratory flow (PEF (MD = 5.45, 95% CI: -2.83-13.72, I2 = 0%, histamine PC20 (MD = -0.62, 95% CI: -1.92-0.68, I2 = 0% or SABA rescue use (MD = -0.11, 95% CI: -0.3-0.07, I2 = 30% were unaffected; adverse events were not increased (RR = 0.93, 95% CI: 0.89-0.98, I2 = 46%. No publication bias was observed (Egger's P = 0.78.Anti-interleukin 5 monoclonal therapies for asthma could be safe for slightly improving FEV1 (or FEV1% of predicted value, quality of life, and reducing exacerbations risk and blood and sputum eosinophils, but have no significant effect on PEF, histamine PC20, and SABA rescue use. Further trials required to establish to clarify the optimal antibody for different patients.

Current Practices and Trends in Mechanical Failure Prevention. Proceedings of the Meeting of the Mechanical Failures Prevention Group (44th) Held in Virginia Beach, Virginia 3-5 April 1990

Science.gov (United States)

1990-01-01

Positron 141 Emission Tomography V. Mashkln and M.R. Hawkesworth iii- Impact of Microfiltration on Spectrometric Oil Analysis 151 C.S. Saba Summary of New...of dollars paid in replacement equip- ment costs paid by casualty insurers. During a loss event, efforts are usually focused on restoring the unit to...amounts to "blade roulette". Good engineering demands thorough root cause analysis, following immediate replacement to restore production. Even

Space power distribution of soft x-ray source ANGARA-5-1

Energy Technology Data Exchange (ETDEWEB)

Dyabilin, K S [High Energy Density Research Center, Moscow (Russian Federation); Fortov, V E; Grabovskij, E V; Lebedev, M E; Smirnov, V P [Troitsk Inst. of Innovative and Fusion Research, Troitsk (Russian Federation)

1997-12-31

The contribution deals with the investigation of shock waves in condensed targets generated by intense pulses of soft X radiation. Main attention is paid to the spatial distribution of the soft x-ray power, which influence strongly the shock wave front uniformity. Hot z-pinch plasma with the temperature of 60-100 eV produced by imploding double liner in the ANGARA-5-1 machine was used as a source of x rays. The maximum pinch current was as high as 3.5 MA. In order to eliminate the thermal heating of the targets, thick stepped Al/Pb, Sn/Pb, or pure Pb targets were used. The velocity of shock waves was determined by means of optical methods. Very uniform shock waves and shock pressures of up to several hundreds of GPa have been achieved. (J.U.). 3 figs., 2 refs.

Excitation of intense shock waves by soft X-radiation

Energy Technology Data Exchange (ETDEWEB)

Branitskij, A V; Fortov, V E; Danilenko, K N; Dyabilin, K S; Grabovskij, E V; Vorobev, O Yu; Lebedev, M E; Smirnov, V P; Zakharov, A E; Persyantsev, I V [Troitsk Inst. of Innovative and Fusion Research, Troitsk (Russian Federation)

1997-12-31

Investigation of the shock waves generated by soft x radiation in Al, Sn, Fe, and Pb targets is reported. The soft x radiation was induced by the dynamic compression and heating of the cylindrical z-pinch plasma generated in the ANGARA-5-1 pulsed power machine. The temperature of the z-pinch plasma was as high as 60 - 120 eV, and the duration of the x-ray pulse reached 30 ns FWHM. Thick stepped Al/Pb, Sn/Pb, and pure Pb targets were used. The results of experiments show that uniform intense shock waves can be generated by z-pinch plasma soft x-ray radiation. The uniformity of the shock is very high. At a flux power of the order of several TW/cm{sup 2}, a shock pressure of some hundreds of GPa was achieved. (J.U.). 3 figs., 11 refs.

Excitation of intense shock waves by soft X-radiation

International Nuclear Information System (INIS)

Branitskij, A.V.; Fortov, V.E.; Danilenko, K.N.; Dyabilin, K.S.; Grabovskij, E.V.; Vorobev, O. Yu.; Lebedev, M.E.; Smirnov, V.P.; Zakharov, A.E.; Persyantsev, I.V.

1996-01-01

Investigation of the shock waves generated by soft x radiation in Al, Sn, Fe, and Pb targets is reported. The soft x radiation was induced by the dynamic compression and heating of the cylindrical z-pinch plasma generated in the ANGARA-5-1 pulsed power machine. The temperature of the z-pinch plasma was as high as 60 - 120 eV, and the duration of the x-ray pulse reached 30 ns FWHM. Thick stepped Al/Pb, Sn/Pb, and pure Pb targets were used. The results of experiments show that uniform intense shock waves can be generated by z-pinch plasma soft x-ray radiation. The uniformity of the shock is very high. At a flux power of the order of several TW/cm 2 , a shock pressure of some hundreds of GPa was achieved. (J.U.). 3 figs., 11 refs

Oma saba söömine Eesti moodi / Kajar Lember

Index Scriptorium Estoniae

Lember, Kajar, 1976-

2008-01-01

Ilmunud ka: Za Narod sept. lk. 3. Rahvaliidu peasekretär, Tabivere vallavolikogu esimees vaatleb ühe- ja kahetasandilise omavalitsusmudeli eeliseid ja puudusi ning nendib, et võimu koondumine süvendab paratamatult erinevusi keskuse ja ääremaa vahel ning haldusreformi puhul kokkuhoiust rääkimine on puhas demagoogia

Venemaa saatis kaks kaugpommitajat Venezuelasse, NATO lennukid sabas / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2008-01-01

Kaks Venemaa pommilennukit lendasid Venezuelasse, novembris läheb Venezuelasse õppustele Vene sõjalaevade eskaader. Vaatlejate hinnangul on tegemist demonstratiivse vastusega USA sõjalaevade saabumisele Mustale merele. Lisa: Ristleja Peeter Suur

Switching patients from other inhaled corticosteroid devices to the Easyhaler®: historical, matched-cohort study of real-life asthma patients

Directory of Open Access Journals (Sweden)

Price D

2014-04-01

Full Text Available David Price,1,2 Vicky Thomas,2 Julie von Ziegenweidt,2 Shuna Gould,2 Catherine Hutton,2 Christine King2 1Academic Centre of Primary Care, University of Aberdeen, Aberdeen, UK; 2Research in Real Life, Oakington, Cambridge, UK Purpose: To investigate the clinical and cost effectiveness of switching real-life asthma patients from other types of inhalers to the Easyhaler® (EH for the administration of inhaled corticosteroids (ICS. Patients and methods: Historical, matched-cohort study of 1,958 asthma patients (children and adults treated in UK primary-care practices, using data obtained from the Optimum Patient Care Research Database and Clinical Practice Research Datalink. Other inhalers (OH included pressurized metered-dose inhalers, breath-actuated inhalers, and dry-powder inhalers, delivering beclomethasone, budesonide, fluticasone, or ciclesonide. Patients remaining on OH unchanged (same drug, dosage, and device; n=979 were matched 1:1 with those switched to the EH (beclomethasone or budesonide at the same or lower ICS dosage (n=979, based on age, sex, year of index patient review/switch, most recent ICS drug, dosage, and device, and the number of severe exacerbations and average daily short-acting β2 agonist (SABA dosage in the preceding year. Clinical outcomes and health care costs were compared between groups for 12 months before and after the switch. Co-primary clinical outcomes were: 1 risk domain asthma control (RDAC – no asthma-related hospitalization, acute oral steroid use, or lower respiratory tract infection (LRTI; 2 exacerbation rate (American Thoracic Society [ATS] definition – where exacerbation is asthma-related hospitalization or acute oral steroid use; 3 exacerbation rate (clinical definition – where exacerbation is ATS exacerbation or LRTI; and 4 overall asthma control (OAC – RDAC plus average salbutamol-equivalent SABA dosage ≤200 μg/day. Non-inferiority (at least equivalence of EH was tested against OH for the

Modified analytic EAM potentials for the binary immiscible alloy systems

International Nuclear Information System (INIS)

Fang, F.; Shu, X.L.; Deng, H.Q.; Hu, W.Y.; Zhu, M.

2003-01-01

Modified analytic embedded atom method (MAEAM) type potentials have been constructed for seven binary immiscible alloy systems: Al-Pb, Ag-Ni, Fe-Cu, Ag-Cu, Cu-Ta, Cu-W and Cu-Co. The potentials are fitted to the lattice constant, cohesive energy, unrelaxed monovacancy formation energy and elastic constants for only pure metals which consist the immiscible alloy systems. In order to test the reliability of the constructed MAEAM potentials, formation enthalpies of disordered alloys for those seven binary immiscible alloy systems have been calculated. The calculated results are in general agreement with the experimental data available and those theoretical results calculated by other authors. As only very limited experimental information is available for alloy properties in immiscible alloy systems, the MAEAM is demonstrated to be a reasonable method to construct the interatomic potentials for immiscible alloy systems because only the properties of pure elements are needed in calculation

Muslim women in the western media: Foucault, agency, governmentality and ethics

OpenAIRE

Vintges, K.

2012-01-01

This article compares the ways in which Saba Mahmood’s The Politics of Piety (2005) and Cressida Heyes’ Self-Transformations: Foucault, Ethics, and Normalization (2007), unlike current governmentality studies, employ the later Foucault’s ethical theory. By explaining the theoretical framework of the ‘middle’ Foucault (governmentality and agency) and the ‘later’ Foucault (ethics and agency) and then comparing Mahmood and Heyes’ use of Foucault’s work, it is argued that Mahmood and Heyes’ analy...

Relationship between macular thickness measurement and signal strength using Stratus optical coherence tomography

OpenAIRE

Segal, Ori; Shapira, Yinon; Gershoni, Assaf; Vainer, Igor; Nemet, Arie Y; Geffen, Noa; Mimouni, Michael

2016-01-01

Ori Segal,1 Yinon Shapira,2 Assaf Gershoni,1 Igor Vainer,2 Arie Y Nemet,1 Noa Geffen,1 Michael Mimouni2 1Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, 2Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel Purpose: To examine the relationship between signal strength and macular thickness as measured by Stratus optical coherence tomography (OCT)’s fast macular thickness protocol...

Kas e-saba leevendab olukorda? / Jelena Kazina, Aleksandr Bõstrov, Raiki Nelk

Index Scriptorium Estoniae

Kazina, Jelena

2010-01-01

Küsimusele elektroonilist piirijärjekorda võimaldava seaduse kohta vastavad Baltliner OÜ projektijuht Jelena Kazina, endine Cargoman OÜ juhataja Aleksandr Bõstrov ja AG Logistik OÜ ekspedeerija Raiki Nelk

The detection of the Earth rotation and revolution effect using the daily and annual variation of sporadic meteor echo by HRO

OpenAIRE

OHNISHI, Kouji; HATTORI, Shinobu; NISHIMURA, Osamu; ISHIKAWA, Toshiyuki; AOKI, Yoshie; IIJIMA, Yukiko; KOBAYASHI, Aya; MAEGAWA, Kimio; ABE, Shinsuke

2001-01-01

Ham-band Radio Observation (HRO) is one of the observational techniques for the forward scatter observation of meteors. We started the observation of the daily and annual variation of sporadic meteor echoes with paired two-element loop antennas (F/B ratio is 10 dB) at the Nagano National College of Technology (Nagano, JAPAN) using the beacon signals at 53.750MHz, 50W from Fukui National College of Technology (Sabae, Fukui, JAPAN) from Aug.2000. The direction of one of this paired antenna was ...

New and emerging treatments for symptomatic tardive dyskinesia

Directory of Open Access Journals (Sweden)

Rana AQ

2013-11-01

Full Text Available Abdul Qayyum Rana,1–4 Zishan M Chaudry,5 Pierre J Blanchet6 1Parkinson's Clinic of Eastern Toronto and Movement Disorders Centre, Toronto, ON, Canada; 2Scarborough Memory Program, Toronto, ON, Canada; 3Journal of Parkinsonism and RLS, Toronto, ON, Canada; 4Bulletin of World Parkinson's Program, Toronto, ON, Canada; 5Saba University School of Medicine, The Bottom, Saba, Dutch Caribbean; 6Department of Stomatology, University of Montreal, Montreal, QC, Canada Abstract: The aim of this review is to assess new, emerging, and experimental treatment options for tardive dyskinesia (TD. The methods to obtain relevant studies for review included a MEDLINE search and a review of studies in English, along with checking reference lists of articles. The leading explanatory models of TD development include dopamine receptor supersensitivity, GABA depletion, cholinergic deficiency, neurotoxicity, oxidative stress, changes in synaptic plasticity, and defective neuroadaptive signaling. As such, a wide range of treatment options are available. To provide a complete summary of choices we review atypical antipsychotics along with resveratrol, botulinum toxin, Ginkgo biloba, tetrabenazine, clonazepam, melatonin, essential fatty acids, zonisamide, levetiracetam, branched-chain amino acids, drug combinations, and invasive surgical treatments. There is currently no US Food and Drug Administration-approved treatment for TD; however, prudent use of atypical antipsychotics with routine monitoring remain the cornerstone of therapy, with experimental treatment options available for further management. Keywords: tardive dyskinesia, first-generation antipsychotics, motor symptoms, schizophrenia, Parkinson's, atypical antipsychotics

Permanencia de las propiedades locales de Randon-Nicodim y de Krein-Milman a través de operadores tauberianos.

OpenAIRE

Brito, Wilman Saba

2005-01-01

Edición Especial Two competing species in an T-periodic environment in N-different locations. Alvarez Gonzáles, Carlos S. Un método de cálculo numérico para integrales definidas. Arellán, Arístides Elpidio; Nieves, Adrían. A note about the maximum principle. Bárcenas Morillo, Diomedes José; Colasante Martínez, María Luisa. Permanencia de las propiedades locales de Randon-Nicodim y de Krein-Milman a través de operadores tauberianos. Brito, Wilman Saba. Some inequalit...

Un método de cálculo numérico para integrales definidas.

OpenAIRE

Arellán, Arístides Elpidio; Nieves, Adrián

2005-01-01

Edición Especial Two competing species in an T-periodic environment in N-different locations. Alvarez Gonzáles, Carlos S. Un método de cálculo numérico para integrales definidas. Arellán, Arístides Elpidio; Nieves, Adrían. A note about the maximum principle. Bárcenas Morillo, Diomedes José; Colasante Martínez, María Luisa. Permanencia de las propiedades locales de Randon-Nicodim y de Krein-Milman a través de operadores tauberianos. Brito, Wilman Saba. Some inequalit...

Feminist dilemmas and the agency of veiled Muslim women

DEFF Research Database (Denmark)

Chapman, Madeleine

2015-01-01

This article addresses dilemmas of agency for feminism through reflections on social psychological research on the role of representations in the construction of identity by Muslim women. Engaging first with Saba Mahmood’s account of religious subjectivities in Politics of Piety (2005), the author...... argues that feminist research requires a social conception of agency that addresses dialogical dynamics of representation and identity. Drawing on research concerning veiling and identity among Muslim women in the UK and Denmark, the author shows how a social conception of agency may be elaborated...

Education through the prism of computation

Science.gov (United States)

Kaurov, Vitaliy

2014-03-01

With the rapid development of technology, computation claims its irrevocable place among research components of modern science. Thus to foster a successful future scientist, engineer or educator we need to add computation to the foundations of scientific education. We will discuss what type of paradigm shifts it brings to these foundations on the example of Wolfram Science Summer School. It is one of the most advanced computational outreach programs run by Wolfram Foundation, welcoming participants of almost all ages and backgrounds. Centered on complexity science and physics, it also covers numerous adjacent and interdisciplinary fields such as finance, biology, medicine and even music. We will talk about educational and research experiences in this program during the 12 years of its existence. We will review statistics and outputs the program has produced. Among these are interactive electronic publications at the Wolfram Demonstrations Project and contributions to the computational knowledge engine Wolfram|Alpa.

A designated centre for people with disabilities operated by Nua Healthcare Services, Clare

LENUS (Irish Health Repository)

Backert, Steffen

2011-11-01

Abstract Helicobacter pylori is a highly successful pathogen uniquely adapted to colonize humans. Gastric infections with this bacterium can induce pathology ranging from chronic gastritis and peptic ulcers to gastric cancer. More virulent H. pylori isolates harbour numerous well-known adhesins (BabA\\/B, SabA, AlpA\\/B, OipA and HopZ) and the cag (cytotoxin-associated genes) pathogenicity island encoding a type IV secretion system (T4SS). The adhesins establish tight bacterial contact with host target cells and the T4SS represents a needle-like pilus device for the delivery of effector proteins into host target cells such as CagA. BabA and SabA bind to blood group antigen and sialylated proteins respectively, and a series of T4SS components including CagI, CagL, CagY and CagA have been shown to target the integrin β1 receptor followed by injection of CagA across the host cell membrane. The interaction of CagA with membrane-anchored phosphatidylserine may also play a role in the delivery process. While substantial progress has been made in our current understanding of many of the above factors, the host cell receptors for OipA, HopZ and AlpA\\/B during infection are still unknown. Here we review the recent progress in characterizing the interactions of the various adhesins and structural T4SS proteins with host cell factors. The contribution of these interactions to H. pylori colonization and pathogenesis is discussed.

ASSESSMENT OF ENVIRONMENTAL AND PUBLIC HEALTH HAZARDS IN WASTEWATER USED FOR URBAN AGRICULTURE IN NAIROBI, KENYA

Directory of Open Access Journals (Sweden)

Nancy Njarua Karanja

2009-08-01

Full Text Available Thirty percent of residents in Nairobi practise urban agriculture (UA with a majority of the farmers using untreated sewage to irrigate crop and fodder. Due to the environmental and health risks associated with wastewater irrigation, a study was carried out in partnership with farmers in Kibera and Maili Saba which are informal settlements along the Ngong River, a tributary of the Nairobi River Basin. Soil, water, crops and human faecal samples from the farming and non-farming households were analysed to elucidate sources, types and level of heavy metal pollutants in the wastewater and the pathogen loads in humans and vegetable crops.  Heavy metal accumulation in soils collected from Kibera and Maili Saba were Cd (14.3 mg kg-1, Cr (9.7 mg kg-1 and Pb (1.7 mg kg-1 and Cd (98.7 mg kg-1,  Cr (4.0 mg kg-1 and Pb (74.3 mg kg-1, respectively.  This led to high phytoaccumulation of Cd, Cr and Pb in the crops that exceeded the maximum permissible limits. No parasitic eggs were detected in the vegetables but coliform count in the wastewater was 4.8 x108±2.2 x1011/100ml. Soils irrigated with this water had parasitic eggs and non-parasitic larvae counts of 54.62 and 27.5/kg respectively. Faecal coliform and parasitic eggs of common intestinal parasites increased in leafy vegetable sampled from the informal markets along the value chain.

Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori

Directory of Open Access Journals (Sweden)

Backert Steffen

2011-11-01

Full Text Available Abstract Helicobacter pylori is a highly successful pathogen uniquely adapted to colonize humans. Gastric infections with this bacterium can induce pathology ranging from chronic gastritis and peptic ulcers to gastric cancer. More virulent H. pylori isolates harbour numerous well-known adhesins (BabA/B, SabA, AlpA/B, OipA and HopZ and the cag (cytotoxin-associated genes pathogenicity island encoding a type IV secretion system (T4SS. The adhesins establish tight bacterial contact with host target cells and the T4SS represents a needle-like pilus device for the delivery of effector proteins into host target cells such as CagA. BabA and SabA bind to blood group antigen and sialylated proteins respectively, and a series of T4SS components including CagI, CagL, CagY and CagA have been shown to target the integrin β1 receptor followed by injection of CagA across the host cell membrane. The interaction of CagA with membrane-anchored phosphatidylserine may also play a role in the delivery process. While substantial progress has been made in our current understanding of many of the above factors, the host cell receptors for OipA, HopZ and AlpA/B during infection are still unknown. Here we review the recent progress in characterizing the interactions of the various adhesins and structural T4SS proteins with host cell factors. The contribution of these interactions to H. pylori colonization and pathogenesis is discussed.

Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori

LENUS (Irish Health Repository)

Backert, Steffen

2011-11-01

Abstract Helicobacter pylori is a highly successful pathogen uniquely adapted to colonize humans. Gastric infections with this bacterium can induce pathology ranging from chronic gastritis and peptic ulcers to gastric cancer. More virulent H. pylori isolates harbour numerous well-known adhesins (BabA\\/B, SabA, AlpA\\/B, OipA and HopZ) and the cag (cytotoxin-associated genes) pathogenicity island encoding a type IV secretion system (T4SS). The adhesins establish tight bacterial contact with host target cells and the T4SS represents a needle-like pilus device for the delivery of effector proteins into host target cells such as CagA. BabA and SabA bind to blood group antigen and sialylated proteins respectively, and a series of T4SS components including CagI, CagL, CagY and CagA have been shown to target the integrin β1 receptor followed by injection of CagA across the host cell membrane. The interaction of CagA with membrane-anchored phosphatidylserine may also play a role in the delivery process. While substantial progress has been made in our current understanding of many of the above factors, the host cell receptors for OipA, HopZ and AlpA\\/B during infection are still unknown. Here we review the recent progress in characterizing the interactions of the various adhesins and structural T4SS proteins with host cell factors. The contribution of these interactions to H. pylori colonization and pathogenesis is discussed.

Solidified structure of Al-Pb-Cu alloys

International Nuclear Information System (INIS)

Ikeda, Tetsuyuki; Nishi, Seiki; Kumeuchi, Hiroyuki; Tatsuta, Yoshinori.

1986-01-01

Al-Pb-Cu alloys were cast into bars or plates in different two metal mold casting processes in order to suppress gravity segregation of Pb and to achieve homogeneous dispersion of Pb phase in the alloys. Solidified structures were analyzed by a video-pattern-analyzer. Plate castings 15 to 20 mm in thickness of Al-Pb-1 % Cu alloy containing Pb up to 5 % in which Pb phase particles up to 10 μm disperse are achieved through water cooled metal mold casting. The plates up to 5 mm in thickness containing Pb as much as 8 to 10 % cast in this process have dispersed Pb particles up to 5 μm in diameter in the surface layer. Al-8 % Pb-1 % Cu alloy bars 40 mm in diameter and 180 mm in height in which gravity segregation of Pb is prevented can be cast by movable and water sprayed metal mold casting at casting temperature 920 deg C and mold moving speed 1.0 mm/s. Pb phase particles 10 μm in mean size are dispersed in the bars. (author)

The Multiple Carbohydrate Binding Specificities of Helicobacter pylori

Science.gov (United States)

Teneberg, Susann

Persistent colonization of the human stomach by Helicobacter pylori is a risk factor for the development of peptic ulcer disease and gastric cancer. Adhesion of microbes to the target tissue is an important determinant for successful initiation, establishment and maintenance of infection, and a variety of different candidate carbohydrate receptors for H. pylori have been identified. Here the different the binding specifities, and their potential role in adhesion to human gastric epithelium are described. Finally, recent findings on the roles of sialic acid binding SabA adhesin in interactions with human neutrophils and erythrocytes are discussed.

Can the response to Omalizumab be influenced by treatment duration? A real-life study.

Science.gov (United States)

Sposato, Bruno; Scalese, Marco; Latorre, Manuela; Novelli, Federica; Scichilone, Nicola; Milanese, Manlio; Olivieri, Carmela; Perrella, Antonio; Paggiaro, Pierluigi

2017-06-01

It is unknown whether Omalizumab effectiveness changes over the course of time. Our retrospective real-life study tried to analyze whether Omalizumab response may be influenced by treatment duration. 340 severe asthmatics treated with Omalizumab for different periods of time were recruited. They were subdivided into 4 groups according to the Omalizumab treatment length: 60 months. Omalizumab treatment results (FEV 1 , exacerbations, ACT, SABA use, asthma control levels, medications used e and ICS doses) were compared. ACT, exacerbations, GINA control levels, ICS doses and SABA use were similar in all groups with different Omalizumab treatment durations. Using a linear regression model, corrected for all confounding variables, a higher significant positive increase in FEV 1 % in subjects treated for 12-24 (β = 9.49; p = 0.034) or 24-60 months (β = 8.56; p = 0.043) was found when compared with subjects treated for a shorter period. Treatment duration was positively associated with a step down of the other associated therapies (OR: 1.013; p = 0.019). This association was more relevant (OR: 4.167; p = 0.005) when we considered Omalizumab treatment duration >60 months compared to the shorter therapy. In particular, the percentage of subjects that were taking Montelukast, LABAs and oral corticosteroids was lower in the group treated with Omalizumab for a longer period of time. In real-life, the positive Omalizumab response remained stable for over 60 months. Long term Omalizumab treatment may lead to a discontinuation of some associated medications and to a slowing down of FEV 1 decline. Copyright © 2017 Elsevier Ltd. All rights reserved.

Antiadhesive Properties of Abelmoschus esculentus (Okra) Immature Fruit Extract against Helicobacter pylori Adhesion

Science.gov (United States)

Shevtsova, Anna; Glocker, Erik; Borén, Thomas; Hensel, Andreas

2014-01-01

Background Traditional Asian and African medicine use immature okra fruits (Abelmoschus esculentus) as mucilaginous food to combat gastritis. Its effectiveness is due to polysaccharides that inhibit the adhesion of Helicobacter pylori to stomach tissue. The present study investigates the antiadhesive effect in mechanistic detail. Methodology A standardized aqueous fresh extract (Okra FE) from immature okra fruits was used for a quantitative in vitro adhesion assay with FITC-labled H. pylori J99, 2 clinical isolates, AGS cells, and fluorescence-activated cell sorting. Bacterial adhesins affected by FE were pinpointed using a dot-blot overlay assay with immobilized Lewisb, sialyl-Lewisa, H-1, laminin, and fibronectin. 125I-radiolabeled Okra FE polymer served for binding studies to different H. pylori strains and interaction experiments with BabA and SabA. Iron nanoparticles with different coatings were used to investigate the influence of the charge-dependence of an interaction on the H. pylori surface. Principal findings Okra FE dose-dependently (0.2 to 2 mg/mL) inhibited H. pylori binding to AGS cells. FE inhibited the adhesive binding of membrane proteins BabA, SabA, and HpA to its specific ligands. Radiolabeled compounds from FE bound non-specifically to different strains of H. pylori, as well as to BabA/SabA deficient mutants, indicating an interaction with a still-unknown membrane structure in the vicinity of the adhesins. The binding depended on the charge of the inhibitors. Okra FE did not lead to subsequent feedback regulation or increased expression of adhesins or virulence factors. Conclusion Non-specific interactions between high molecular compounds from okra fruits and the H. pylori surface lead to strong antiadhesive effects. PMID:24416297

Accelerating Electrostatic Surface Potential Calculation with Multiscale Approximation on Graphics Processing Units

Science.gov (United States)

Anandakrishnan, Ramu; Scogland, Tom R. W.; Fenley, Andrew T.; Gordon, John C.; Feng, Wu-chun; Onufriev, Alexey V.

2010-01-01

Tools that compute and visualize biomolecular electrostatic surface potential have been used extensively for studying biomolecular function. However, determining the surface potential for large biomolecules on a typical desktop computer can take days or longer using currently available tools and methods. Two commonly used techniques to speed up these types of electrostatic computations are approximations based on multi-scale coarse-graining and parallelization across multiple processors. This paper demonstrates that for the computation of electrostatic surface potential, these two techniques can be combined to deliver significantly greater speed-up than either one separately, something that is in general not always possible. Specifically, the electrostatic potential computation, using an analytical linearized Poisson Boltzmann (ALPB) method, is approximated using the hierarchical charge partitioning (HCP) multiscale method, and parallelized on an ATI Radeon 4870 graphical processing unit (GPU). The implementation delivers a combined 934-fold speed-up for a 476,040 atom viral capsid, compared to an equivalent non-parallel implementation on an Intel E6550 CPU without the approximation. This speed-up is significantly greater than the 42-fold speed-up for the HCP approximation alone or the 182-fold speed-up for the GPU alone. PMID:20452792

Respiratory medication used in COPD patients from seven Latin American countries: the LASSYC study.

Science.gov (United States)

Casas, Alejandro; Montes de Oca, Maria; Menezes, Ana Mb; Wehrmeister, Fernando C; Lopez Varela, Maria Victorina; Mendoza, Laura; Ramírez, Larissa; Miravitlles, Marc

2018-01-01

Limited information is available regarding medication use in COPD patients from Latin America. This study evaluated the type of medication used and the adherence to different inhaled treatments in stable COPD patients from the Latin American region. This was an observational, cross-sectional, multinational, and multicenter study in COPD patients attended by specialist doctors from seven Latin American countries. Adherence to inhaled therapy was assessed using the Test of Adherence to Inhalers (TAI) questionnaire. The type of medication was assessed as: short-acting β-agonist (SABA) or short-acting muscarinic antagonist (SAMA) only, long-acting muscarinic antagonist (LAMA), long-acting β-agonist (LABA), LABA/LAMA, inhaled corticosteroid (ICS), ICS/LABA, ICS/LAMA/LABA, or other. In total, 795 patients were included (59.6% male), with a mean age of 69.5±8.7 years and post-bronchodilator FEV 1 of 50.0%±18.6%. The ICS/LAMA/LABA (32.9%) and ICS/LABA (27.7%) combinations were the most common medications used, followed by LABA/LAMA (11.3%), SABA or SAMA (7.9%), LABA (6.4%), LAMA (5.8%), and ICS (4.3%). The types of medication most commonly used in each Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2013 category were ICS/LABA (A: 32.7%; B: 19.8%; C: 25.7%; D: 28.2%) and ICS/LAMA/LABA (A: 17.3%; B: 30.2%; C: 33%; D: 41.1%). The use of long-acting bronchodilators showed the highest adherence (good or high adherence >50%) according to the TAI questionnaire. COPD management in specialist practice in Latin America does not follow the current guideline recommendations and there is an overuse of ICSs in patients with COPD from this region. Treatment regimens including the use of long-acting bronchodilators are associated with the highest adherence.

Treatment of arsenic contaminated water in a batch reactor by using Ralstonia eutropha MTCC 2487 and granular activated carbon

International Nuclear Information System (INIS)

Mondal, P.; Majumder, C.B.; Mohanty, B.

2008-01-01

This paper presents the observations on the bio-removal of arsenic from contaminated water by using Ralstonia eutropha MTCC 2487 and activated carbon in a batch reactor. The effects of agitation time, pH, type of granular activated carbon (GAC) and initial arsenic concentration (As o ) on the % removal of arsenic have been discussed. Under the experimental conditions, optimum removal was obtained at the pH of 6-7 with agitation time of 100 h. The % removal of As(T) increased initially with the increase in As o and after attaining the maximum removal (∼86%) at the As o value of around 15 ppm, it started to decrease. Simultaneous adsorption bioaccumulation (SABA) was observed, when fresh GAC was used as supporting media for bacterial immobilization. In case of SABA, the % removal of As(III) was almost similar (only ∼1% more) to the additive values of individual removal of As(III) obtained by only adsorption and only bio-adsorption. However, for As(V) the % removal was less (∼8%) than the additive value of the individual % removals obtained by only adsorption and bio-adsorption. Percentage removal of Fe, Mn, Cu and Zn were 65.17%, 72.76%, 98.6% and 99.31%, respectively. Maximum regeneration (∼99.4%) of the used bio-adsorbent was achieved by the treatment with 5NH 2 SO 4 followed by 1N NaOH and 30% H 2 O 2 in HNO 3 . The fitness of the isotherms to predict the specific uptake for bio-adsorption/accumulation process has been found to decrease in the following order: Temkin isotherm > Langmuir isotherm > Freundlich isotherm. For the adsorption process with fresh GAC the corresponding order is Freundlich isotherm > Langmuir isotherm > Temkin isotherm for As(V) and As(T). However, for As(III) it was Langmuir > Temkin > Freundlich

Pilot study on behaviour of sharks around Saba using acoustic telemetry - Progress report 2014

NARCIS (Netherlands)

Winter, H.V.; Vink, D.; Beek, van I.J.M.

2015-01-01

Worldwide many shark populations are in strong decline mainly due to fisheries. Population status of sharks in the Caribbean is still poorly known. In order to be able to take effective measures to protect sharks, insight in their spatial behaviour during different life stages is required. Do marine

KEPEMIMPINAN TRANSFORMASIONAL, TRANSAKSIONAL, MOTIVASI KERJA, DAN KINERJA PERSONEL SATUAN PROVOST DETASEMEN MARKAS MABES ANGKATAN LAUT

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Lutfi Adin Affandi

2017-09-01

Full Text Available The study aimed to investigate the effect of transformational leadership, transactional leadership and work of motivation on performance of personnel (Y provost detachment headquarter of Indonesian Navy, either simultaneously or partialy. 59 respondent from provost detachment headquarter of Indonesian Navy, completed 71 item self-reorted measures. The data collected survey and quesionares distributed to respondent. The statistic methode used was Multiple Regression. As expected, result indicated that transformational leadership, transactional leadership and work of motivation has positive effects on performance personnel. The result show that Fcount26.154 is greater than Ftable 2.77 at significant level 0.05 then H0 is rejected, which means that the transformational leadership (X1, transactional leadership (X2 and work of motivation (X3 together-equally significant effect on performance of personnel (Y. Partial test, all the independent variables have a value of significant alpa below 0.05 or tcount independent variables is greater than ttables thus proving the influence of transformational leadership, transactional leadership and work of motivation partially on performance personnel.

Spatial structure of a natural mixed topodeme of subalpine Sorbus taxa

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Dušan Gömöry

2011-01-01

Full Text Available Spatial distribution and genetic variation of a population of Sorbus chamaemespilus (L. Crantz and putative hybrids between S. chamaemespilus, S. aria and S. aucuparia growing in the nature reserve Skalnä Alpa (central Slovakia were studied. The analysis of spatial patterns using Ripley's K-function revealed a significant clustering of the adults of both S. chamaemespilus and hybrid taxa at distances up to ~15 m and a strong affinity between both taxonomical groups, indicating similar ecological requirements. Bivariate point-pattern analysis considering cardinal direction showed that juvenile individuals of S. chamaemespilus are clustered around the adults up to the distance of ~2 m, whereas in hybrid taxa with larger and more dense crowns, juveniles are clustered at distances more than ~3 m from the adults. The analysis of genetic variation in a subset of adult shrubs using 4 nuclear microsatellite loci revealed that unlike expected, there was no variation in S. chamaemespilus but several genotypes were found in the group of hybrid taxa. Implications for the reproduction system and conservation of the investigated taxa are discussed.

Effect of a price discount and consumer education strategy on food and beverage purchases in remote Indigenous Australia: a stepped-wedge randomised controlled trial.

Science.gov (United States)

Brimblecombe, Julie; Ferguson, Megan; Chatfield, Mark D; Liberato, Selma C; Gunther, Anthony; Ball, Kylie; Moodie, Marj; Miles, Edward; Magnus, Anne; Mhurchu, Cliona Ni; Leach, Amanda Jane; Bailie, Ross

2017-02-01

Evidence is mounting that price discounts can be effective in improving diet. This study examined the effectiveness of a 20% price discount on food and drink purchases with and without consumer education in remote Indigenous Australia. A 20% discount on fruit, vegetables, water, and artificially sweetened soft drinks was applied for 24 weeks in 20 communities in remote Indigenous Australia where the community store was managed by the Arnhem Land Progress Aboriginal Corporation (ALPA) or Outback Stores (OBS) in a stepped-wedge randomised trial. Communities were randomly allocated to a fixed framework of five sets of four stratified by store association; ten stores (two in each set) were randomly assigned to receive consumer education. A store from each of the ALPA and OBS store groups (contained in separate opaque envelopes) was selected, and stores in turn continued to be consecutively allocated to the fixed store set framework, starting with the first store slot in the first store set, until all stores had been allocated. The effect of the discount on the weight of fruit and vegetables purchased (the primary endpoint) was assessed using weekly store sales data and mixed models per protocol. We did sensitivity analyses by repeating the analyses with the outliers included and repeating the analyses for the primary outcome measure removing each store one at a time. This trial was registered with Australian New Zealand Clinical Trials Registry, number ACTRN12613000694718. Weekly store sales data on all food and drink products sold in 20 stores were collected from July 1, 2012, to Dec 28, 2014. Price discount alone was associated with a 12·7% (95% CI 4·1-22·1) increase in purchases in grams of fruit and vegetables combined (primary outcome), and a 19·8% (6·2-35·1) increase post discount (after vs before); an effect of 12 g and 18 g per capita per day. Sensitivity analyses did not modify the results for the primary outcome measure. A 20% discount can only increase

2nd seminar on radioscopy

International Nuclear Information System (INIS)

1991-01-01

This seminar record contains 10 articles on the following subjects: The function and properties of modern radioscopy systems (H. Heidt); systems producing pictures compared to weld seams (R. Limpert); automatic fault assessment on cast parts (D. Filbert); practical experience with computer-aided irradiation tests on car steering housings and crude cast wheels - SABA test system (M. Purschke); concepts and experience in the automatic interpretation of weld seam pictures (P. Rose); the significance of the size and shape of burnt spots in the radioscopy process (E. Kirchner); detector systems in radioscopy (R. Link); radioscopy systems with automatic testing and integrated picture processing (R. Grimm); automatic testing of light alloy wheels for cars in practice (Part 1: K. Doerrich, Part 2: G. Korthals). (HM) [de

SELEKSI DAN PEMANFAATAN ACTINOMYCETES SEBAGAI MIKROBA ANTAGONIS YANG RAMAH LINGKUNGAN TERHADAP Fusarium oxysporum f.sp. cubense SECARA IN VITRO

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I MADE SUDARMA

2015-06-01

Full Text Available A total of 119 different actinomycete isolate were recovered from banana crop habitats with and without Fusarium wilt disease symptom. These were than assessed for their antagonist ability against Fusarium oxysporum £sp. cubense (Foe in vitro. Results indicated that four of all actinomycete isolate active against Foe. The four of actinomycete isolates were Streptomyces sp. l (AAo4, Streptomyces sp.2 (AAo32 , Streptomyces sp.3 (AAo33 and Streptomyces sp. 4 (AAo35. It was can inhibit the Foe mycelium growth, 79,63%, 72,22%, 78,89% and 72,22% respectively. After tested with the 3 times replication, the four Streptomyces spp. isolate effective to control the Foe that attack Bali banana cultivars, such as Susu, Saba, Raja and Ketip.

Accelerating electrostatic surface potential calculation with multi-scale approximation on graphics processing units.

Science.gov (United States)

Anandakrishnan, Ramu; Scogland, Tom R W; Fenley, Andrew T; Gordon, John C; Feng, Wu-chun; Onufriev, Alexey V

2010-06-01

Tools that compute and visualize biomolecular electrostatic surface potential have been used extensively for studying biomolecular function. However, determining the surface potential for large biomolecules on a typical desktop computer can take days or longer using currently available tools and methods. Two commonly used techniques to speed-up these types of electrostatic computations are approximations based on multi-scale coarse-graining and parallelization across multiple processors. This paper demonstrates that for the computation of electrostatic surface potential, these two techniques can be combined to deliver significantly greater speed-up than either one separately, something that is in general not always possible. Specifically, the electrostatic potential computation, using an analytical linearized Poisson-Boltzmann (ALPB) method, is approximated using the hierarchical charge partitioning (HCP) multi-scale method, and parallelized on an ATI Radeon 4870 graphical processing unit (GPU). The implementation delivers a combined 934-fold speed-up for a 476,040 atom viral capsid, compared to an equivalent non-parallel implementation on an Intel E6550 CPU without the approximation. This speed-up is significantly greater than the 42-fold speed-up for the HCP approximation alone or the 182-fold speed-up for the GPU alone. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Phase formation in multicomponent monotectic aluminium alloys

Energy Technology Data Exchange (ETDEWEB)

Mirkovic, Djordje; Groebner, Joachim; Schmid-Fetzer, Rainer [Institute of Metallurgy, Clausthal University of Technology (Germany)

2008-07-01

Alloys with a miscibility gap in the liquid state are potential materials for advanced bearings in automotive and other applications. While binary alloys, such as Al-Pb or Al-Bi, are well known, the information available for ternary monotectic Al-alloys is scarce. However, the phase formation in multicomponent alloys is not only more challenging from a scientific aspect, it is also a prerequisite for a focused development of advanced alloys. This motivated our detailed study of monotectic Al-Bi-Cu-Sn alloys including both experimental and computational thermodynamic methods. Based on the initially established systematic classification of monotectic ternary Al-alloys, the first promising monotectic reaction was observed in the ternary Al-Bi-Zn system. Further ternary systems Al-Cu-Sn, Al-Bi-Sn, Al-Bi-Cu and Bi-Cu-Sn were investigated as basis for quaternary Al-Bi-Cu-Sn alloys. Experimental investigations of phase equilibria, enthalpies and solidification microstructures were combined with thermodynamic modeling. The results demonstrate that the developed precise thermodynamic description is vital to reveal the distinct multicomponent monotectic features of pertinent phase diagrams. The solidification paths of ternary monotectic alloy systems, Al-Bi-Zn, Al-Sn-Cu and Al-Bi-Cu, were also studied using thermodynamic calculations, revealing specific details of phase formation during solidification of selected alloys.

Association of asthma therapy and Churg-Strauss syndrome: an analysis of postmarketing surveillance data.

Science.gov (United States)

DuMouchel, William; Smith, Eric T; Beasley, Richard; Nelson, Harold; Yang, Xionghu; Fram, David; Almenoff, June S

2004-07-01

Churg-Strauss syndrome (CSS), also known as allergic granulomatous angiitis (AGA), is a rare vasculitis that occurs in patients with bronchial asthma. The nature of the association of CSS with various asthma therapies is unclear. This study investigated the associations of different multidrug asthma therapy regimens and the reporting of AGA (the preferred code for CSS in the coding dictionary for the Adverse Event Reporting System [AERS]) by applying an iterative method of disproportionally analysis to th AERS database maintained by the US Food and Drug Administration. The public-release version of the AERS database was used to identify reports of AGA in patients receiving asthma therapy. Reporting of AGA was examined using iterative disproportionality methods in patients receiving > or =1 of the following drug classes: inhaled corticosteroid (ICS), leukotriene receptor antagonist (LTRA), short-acting beta(2)-agonist (SABA), or long-acting beta(2)-agonist (LABA). The Bayesian data-mining algorithm known as the multi-item gamma poisson shrinker was used to determine the relative reporting rates by calculation of the empirical Bayes geometric mean (EBGM) and its 90% CI (EB05 = lower limit and EB95 = upper limit) for each drug. Subset analyses were performed for each drug with different medication combinations to differentiate the relative reporting of AGA for each. A strong association was found between LTRA use and AGA (EBGM = 104.0, EB05 = 95.0, EB95 = 113.8) that persisted with all combinations of therapy studied. AGA was also associated with the ICS, SABA and LABA classes (EBGM values of 27.8, 14.6 and 40.4, respectively). However, the latter associations were mostly dependent on the presence of concurrent LTRA and, to a lesser extemt, oral corticosteroid therapy and became negligible (ie, EB05 < 2) for patients who were not receiving these concurrent treatments. Differences based on relative reporting were observed in the patterns of association of AGA with LTRA

A self-lysis pathway that enhances the virulence of a pathogenic bacterium.

Science.gov (United States)

McFarland, Kirsty A; Dolben, Emily L; LeRoux, Michele; Kambara, Tracy K; Ramsey, Kathryn M; Kirkpatrick, Robin L; Mougous, Joseph D; Hogan, Deborah A; Dove, Simon L

2015-07-07

In mammalian cells, programmed cell death (PCD) plays important roles in development, in the removal of damaged cells, and in fighting bacterial infections. Although widespread among multicellular organisms, there are relatively few documented instances of PCD in bacteria. Here we describe a potential PCD pathway in Pseudomonas aeruginosa that enhances the ability of the bacterium to cause disease in a lung infection model. Activation of the system can occur in a subset of cells in response to DNA damage through cleavage of an essential transcription regulator we call AlpR. Cleavage of AlpR triggers a cell lysis program through de-repression of the alpA gene, which encodes a positive regulator that activates expression of the alpBCDE lysis cassette. Although this is lethal to the individual cell in which it occurs, we find it benefits the population as a whole during infection of a mammalian host. Thus, host and pathogen each may use PCD as a survival-promoting strategy. We suggest that activation of the Alp cell lysis pathway is a disease-enhancing response to bacterial DNA damage inflicted by the host immune system.

Control de Sustancias Agotadoras de la Capa de Ozono (SAO en vehículos importados

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Miguel Antonio Cano-Pérez

2011-01-01

Full Text Available Se aborda el estudio sobre importaciones de vehículos, realizadas en la provincia de Holguín por las entidades MOA DIESEL S.A. y UNEVOL S.A, en el año 2009, con sistemas de aire acondicionado incorporados, sin la comprobación por la Aduana, ni por los especialistas del Centro de Inspección Ambiental del Ministerio de Ciencia, Tecnología y Medio Ambiente (CITMA acreditados al efecto, del tipo de gas refrigerante de los sistemas de climatización. Señala las partidas arancelarias de los vehículos que presentan los sistemas con gases refrigerantes y sustancias agotadoras de la capa de ozono. Argumenta que al no estar oficialmente establecido el control de ellos en los aires acondicionados de los vehículos, deja una brecha abierta por la cual pueden entrar alpaís sustancias agotadoras de la capa de ozono, sin el debido control, ni la correspondiente certificación. Se presentó la propuesta de la vía y forma para el control tanto por la Aduana, como por el CITMA.

Increased risk of sudden cardiac arrest in obstructive pulmonary disease

DEFF Research Database (Denmark)

Warnier, Miriam Jacoba; Blom, Marieke Tabo; Bardai, Abdennasser

2013-01-01

BACKGROUND: We aimed to determine whether (1) patients with obstructive pulmonary disease (OPD) have an increased risk of sudden cardiac arrest (SCA) due to ventricular tachycardia or fibrillation (VT/VF), and (2) the SCA risk is mediated by cardiovascular risk-profile and/or respiratory drug use...... with electrocardiographic documentation of VT/VF were included. Conditional logistic regression analysis was used to assess the association between SCA and OPD. Pre-specified subgroup analyses were performed regarding age, sex, cardiovascular risk-profile, disease severity, and current use of respiratory drugs. RESULTS...... is associated with an increased observed risk of SCA. The most increased risk was observed in patients with a high cardiovascular risk-profile, and in those who received SABA and, possibly, those who received AC at the time of SCA....

Montelukast use-a 19-year nationwide drug utilisation study

DEFF Research Database (Denmark)

Henriksen, Daniel Pilsgaard; Davidsen, Jesper Rømhild; Laursen, Christian B

2017-01-01

PURPOSE: Montelukast is a leukotriene receptor antagonist used in asthma and rhinitis treatment. Despite being marketed nearly two decades ago, little is known about its utilisation pattern. METHODS: Using the Danish National Prescription Registry, we identified subjects filling a montelukast...... montelukast initiators, 60% filled at least one prescription of short-acting beta-2-agonists (SABA) up to a year prior to montelukast initiation, and 49% filled a prescription of inhaled corticosteroids (ICS). Only 0.8% (n = 1148) of all individuals initiated montelukast without a redeemed prescription...... of short- or long-term inhalation therapy, systemic antihistamines, or nasal topical anti-allergic treatment. CONCLUSIONS: The usage of montelukast has increased over threefold since its market entry in 1998, mainly driven by an increased number of prevalent users. The majority of individuals who initiated...

Octavio Paz: traducción y relaciones literarias

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Celene García-Ávila

2014-01-01

Full Text Available Octavio Paz no solamente destacó como poeta, sino también como traductor de poesía. El propósito de este trabajo es señalar que a Paz le intere - saba la traducción de poesía no sólo como un reto lingüístico; y practicaba esta actividad para ampliar sus horizontes culturales, literarios y filosóficos. Por ello, se discute la relación epistolar entre el poeta y Tomás Segovia, y se evidencia la intención de publicar entre un 30 y un 40 por ciento de traducciones en la revis - ta Vuelta. Por último, se comparan dos poemas en prosa escritos originalmente en francés con las respectivas traducciones de Paz.

La matanza de los inocentes. Intelectuales cubanas en defensa del niño español

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Niall Binns

2011-07-01

Full Text Available El artículo estudia el impacto que tuvo en siete intelectuales cubanas la Guerra Civil Española y, concretamente, las imágenes de niños muertos en los bombardeos aéreos de Madrid y otras ciudades republicanas. Estas imágenes, divulgadas por la prensa y los noticiarios cinematográficos, se reiteran obsesivamente en los escritos de Mariblanca Sabas Alomá, Serafina Núñez, Berta Arocena, Mirta Aguirre, Fina García Marruz, Emma Pérez y Teté Casuso. Estas intelectuales cubanas, arropadas por el prestigioso ejemplo de Gabriela Mistral, apelan a su sensibilidad “maternal” para expresar su compasión y para justificar su indignación y su activismo político en defensa del niño español.

The effect of Cu addition and milling contaminations on the microstructure evolution of ball milled Al-Pb alloy during sintering

International Nuclear Information System (INIS)

Zhu, M.; Ouyang, L.Z.; Wu, Z.F.; Zeng, M.Q.; Li, Y.Y.; Zou, J.

2006-01-01

Al-10 wt.%Pb and Al-10 wt.%Pb-x wt.%Cu (x = 0-7.0) bulk alloys were prepared by sintering the mechanically alloyed powders at various temperatures. The microstructure changes of the as consolidated powders in the course of sintering were analyzed by differential scanning calorimetry, scanning electron microscopy, X-ray diffraction analysis and transmission electron microscopy. It has been found that, with respect to the Al-10 wt.%Pb-x wt.%Cu alloy, CuAl 2 and Cu 9 Al 4 phases formed in the milling process, and the amount of CuAl 2 phase increased while the Cu 9 Al 4 phase disappeared gradually in the sintering process. In both Al-10 wt.%Pb and Al-10 wt.%Pb-x wt.%Cu alloys, the sintering process results in the coarsening of Pb phase and the growth rate of Pb phase fulfills the Lifshitz-Slyozov-Wagner equation even though the size of the Pb phase was in nanometer range. The Pb particle exhibits cuboctahedral morphology and has a cubic to cubic orientation relationship with the Al matrix. The addition of Cu strongly depressed the growth rate of Pb. Contamination induced by milling has apparent influence on the microstructure of the sintered alloys. Al 7 Cu 2 Fe and aluminium oxide phases were identified in the sintered alloys. The cuboctahedral morphology of Pb particles was broken up by the presence of the oxide phase

The Effectiveness of Stress Management Program on Quality of Life among Methadone Maintenance Treatment Members

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s Zarei

2014-11-01

Full Text Available Objective: The aim of present study was to investigate the effectiveness of stress management program on quality of life among methadone maintenance treatment members. Method: In this pre-test, post-test experimental study, 30 individual who referred to Saba MMT center in Pakdasht were randomly divided into experimental group (n=15 participants and control group (n=15 participants. The experimental group was undergone ten 90 minutes sessions of stress management program and the control group didn’t receive any treatment program. Quality of life questionnaire (SF-36 was administered. Result: The results showed that the mean sf-36 score in the experimental group had significant higher increased in comparison of control group. Conclusion: It can be concluded stress management program is effective on increasing of quality of life among methadone maintenance treatment members.

Dialogo su psicoanalisi e poesia (1946

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Benedetto Croce

2013-02-01

Full Text Available Nel 1946 “La Fiera letteraria” ospitò due importanti interventi dedicati a psicoanalisi e poesia. Il primo, per mano nientemeno che di Benedetto Croce, era una lettera di poche pagine, di sostanziale chiusura nei confronti delle pretese novità e originalità del “freudismo” soprattutto in ambito filosofico. Il secondo era la risposta, molto più dettagliata e articolata di un poeta come Umberto Saba, che invece alla psicoanalisi (e non solo come terapia credeva e teneva molto. Riproponiamo qui questi due testi, preceduti da altri due brevi interventi di Croce sulla psicoanalisi: il primo è una recensione alla traduzione francese del testo di Freud sul sogno del 1903; il secondo è una critica sprezzante nei confronti della “cosiddetta critica stilistica”, che viene messa in relazione al metodo Montessori e appunto alla psicoanalisi. 

INFLUENCE OF RAW IMAGE PREPROCESSING AND OTHER SELECTED PROCESSES ON ACCURACY OF CLOSE-RANGE PHOTOGRAMMETRIC SYSTEMS ACCORDING TO VDI 2634

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J. Reznicek

2016-06-01

Full Text Available This paper examines the influence of raw image preprocessing and other selected processes on the accuracy of close-range photogrammetric measurement. The examined processes and features includes: raw image preprocessing, sensor unflatness, distance-dependent lens distortion, extending the input observations (image measurements by incorporating all RGB colour channels, ellipse centre eccentricity and target detecting. The examination of each effect is carried out experimentally by performing the validation procedure proposed in the German VDI guideline 2634/1. The validation procedure is based on performing standard photogrammetric measurements of high-accurate calibrated measuring lines (multi-scale bars with known lengths (typical uncertainty = 5 μm at 2 sigma. The comparison of the measured lengths with the known values gives the maximum length measurement error LME, which characterize the accuracy of the validated photogrammetric system. For higher reliability the VDI test field was photographed ten times independently with the same configuration and camera settings. The images were acquired with the metric ALPA 12WA camera. The tests are performed on all ten measurements which gives the possibility to measure the repeatability of the estimated parameters as well. The influences are examined by comparing the quality characteristics of the reference and tested settings.

Microtubule plus end-tracking proteins play critical roles in directional growth of hyphae by regulating the dynamics of cytoplasmic microtubules in Aspergillus nidulans.

Science.gov (United States)

Zeng, Cui J Tracy; Kim, Hye-Ryun; Vargas Arispuro, Irasema; Kim, Jung-Mi; Huang, An-Chi; Liu, Bo

2014-11-01

Cytoplasmic microtubules (MTs) serve as a rate-limiting factor for hyphal tip growth in the filamentous fungus Aspergillus nidulans. We hypothesized that this function depended on the MT plus end-tracking proteins (+TIPs) including the EB1 family protein EBA that decorated the MT plus ends undergoing polymerization. The ebAΔ mutation reduced colony growth and the mutant hyphae appeared in an undulating pattern instead of exhibiting unidirectional growth in the control. These phenotypes were enhanced by a mutation in another +TIP gene clipA. EBA was required for plus end-tracking of CLIPA, the Kinesin-7 motor KipA, and the XMAP215 homologue AlpA. In addition, cytoplasmic dynein also depended on EBA to track on most polymerizing MT plus ends, but not for its conspicuous appearance at the MT ends near the hyphal apex. The loss of EBA reduced the number of cytoplasmic MTs and prolonged dwelling times for MTs after reaching the hyphal apex. Finally, we found that colonies were formed in the absence of EBA, CLIPA, and NUDA together, suggesting that they were dispensable for fundamental functions of MTs. This study provided a comprehensive delineation of the relationship among different +TIPs and their contributions to MT dynamics and unidirectional hyphal expansion in filamentous fungi. © 2014 John Wiley & Sons Ltd.

Disruption of ten protease genes in the filamentous fungus Aspergillus oryzae highly improves production of heterologous proteins.

Science.gov (United States)

Yoon, Jaewoo; Maruyama, Jun-ichi; Kitamoto, Katsuhiko

2011-02-01

Proteolytic degradation by secreted proteases into the culture medium is one of the significant problems to be solved in heterologous protein production by filamentous fungi including Aspergillus oryzae. Double (tppA, and pepE) and quintuple (tppA, pepE, nptB, dppIV, and dppV) disruption of protease genes enhanced human lysozyme (HLY) and bovine chymosin (CHY) production by A. oryzae. In this study, we used a quintuple protease gene disruptant and performed successive rounds of disruption for five additional protease genes (alpA, pepA, AopepAa, AopepAd, and cpI), which were previously investigated by DNA microarray analyses for their expression. Gene disruption was performed by pyrG marker recycling with a highly efficient gene-targeting background (∆ligD) as previously reported. As a result, the maximum yields of recombinant CHY and HLY produced by a decuple protease gene disruptant were approximately 30% and 35%, respectively, higher than those produced by a quintuple protease gene disruptant. Thus, we successfully constructed a decuple protease gene disruptant possessing highly improved capability of heterologous protein production. This is the first report on decuple protease gene disruption that improved the levels of heterologous protein production by the filamentous fungus A. oryzae.

A study of radioactive elements of various rocks in Pattani Province with gamma ray spectrometer

Directory of Open Access Journals (Sweden)

Kaewtubtim, P.

2002-01-01

Full Text Available The radioactivity of the three elements, potassium, uranium and thorium, in rocks of various types in Pattani Province was investigated by using a gamma ray spectrometer. It was found that potassium contents in igneous rocks, sedimentary rocks and metamorphic rocks were 6.29 %, 2.21% and 1.54 % respectively. Uranium equivalent contents in igneous rock, sedimentary rocks and metamorphic rocks were found to be 22.51 ppm, 11.25 ppm and 14.13 ppm, while thorium contents in these rocks were 21.78 ppm, 18.88 ppm and 18.15 ppm respectively. The results obtained were similar to those reported by Pungtip Ranglek (1995 for igneous rock at Liwong Pluton site in Thepha, Na Thawi, Chana and Saba Yoi Districts, Songkhla Province, and were about six times higher than those reported by Kittichai Wattananikorn (1994 for igneous rock in the northern part of Thailand.

77 FR 35108 - Gulf, Colorado & San Saba Railway; Emergency Order To Prevent Operation of Trains Over the...

Science.gov (United States)

2012-06-12

... potentially deadly accident can be prevented. See 49 CFR part 234. U.S. Highway 87 is a busy four-lane highway... approximately 16 school buses currently traverse the crossing daily, Monday through Friday. The track adjacent...

Revision of clinical case definitions: influenza-like illness and severe acute respiratory infection/ Julia Fitzner ; Saba Qasmieh

Index Scriptorium Estoniae

Fitzner, Julia

2018-01-01

Pärast 2009.- 2010. aasta gripi H1N1 pandeemiat algatas Maailma Terviseorganisatsioon (WHO) tehnilise konsultatsiooni ülemaailmse gripi seire kohta. WHO uute juhtumite määratluste ülemaailmne kasutamine aitab määrata globaalsete suundumuste näitajaid ja gripiviirustega kaasnevaid haigusi

ALICE installs new hardware in preparation for the 2012 run

CERN Multimedia

CERN Bulletin and ALICE Matters

2012-01-01

2011 was a fantastic year for the heavy-ion run at ALICE despite unprecedented challenges and difficult conditions. The data collected is at least one order of magnitude greater than the 2010 data. Thanks to a planned upgrade to two subdetectors during the 2011/2012 winter shutdown and a reorganisation of ALICE’s Physics Working Groups that should allow them to better deal with the greater challenges imposed by the LHC, the collaboration is confident that the 2011 run will allow ALICE to extend its physics reach and improve its performance.   Photograph of ALICE taken by Antonio Saba during this year's winter shutdown. The annual winter shutdown has been a very intense period for the ALICE collaboration. In conjunction with the general maintenance, modifications and tests of the experiment, two major projects – the installation of 3 supermodules of the Transition Radiation Detector (TRD) and 2 supermodules of the Electromagnetic Calorimeter (EMCal) – hav...

ALICE bags data storage accolades

CERN Multimedia

2007-01-01

ComputerWorld has recognized CERN with an award for the 'Best Practices in Storage' for ALICE's data acquisition system, in the category of 'Systems Implementation'. The award was presented to the ALICE DAQ team on 18 April at a ceremony in San Diego, CA. (Top) ALICE physicist Ulrich Fuchs. (Bottom) Three of the five storage racks for the ALICE Data Acquisition system (Photo Antonio Saba). Between 16 and19 April, one thousand people from data storage networks around the world gathered to attend the biannual Storage Networking World Conference. Twenty-five companies and organizations were celebrated as finalists, and five of those were given honorary awards-among them CERN, which tied for first place in the category of Systems Implementation for the success of the ALICE Data Acquisition System. CERN was one of five finalists in this category, which recognizes the winning facility for 'the successful design, implementation and management of an interoperable environment'. 'Successful' could include documentati...

Mineralogia e química dos sedimentos de fundo do médio e baixo Madeira e de seus principais tributários: Amazonas - Brasil Mineralogy and chemistry of bottom sediments of the middle and lower Madeira River and its main tributaries: Amazonas - Brazil

Directory of Open Access Journals (Sweden)

Maria Mireide Andrade Queiroz

2011-01-01

Full Text Available O objetivo deste trabalho foi investigar a variação composicional e mineralógica dos sedimentos de fundo transportados pelos grandes rios da Amazônia, com nascentes nos Andes provenientes de rochas cratônicas. O estudo foi realizado com base em análises granulométricas, mineralógicas e químicas, incluindo isótopos de Pb, no rio Madeira e seus tributários. O conjunto de dados mostra que os sedimentos de fundo do rio Madeira são granulométrica, mineralógica e quimicamente distintos de seus principais tributários. Os sedimentos do rio Madeira são mais arenosos; têm maior quantidade de quartzo; menor conteúdo de Al2O3, Fe2O3, K2O, MgO, Na2O, PF, TiO2, P2O5, MnO e elementos-traço; e a maturidade aumenta de montante para jusante. Dentre os sedimentos dos tributários, os rios Machado e secundariamente o rio Marmelos são os que mais se aproximam da composição dos sedimentos do rio Madeira, enquanto que o Jamari com sedimentos com maior proporção de TiO2, Zr, Y, Nb, Ga, Hf, U, Ta e ETR, é o mais distinto. Apesar do ambiente de intenso intemperismo e erosão, em condições tropicais úmidas, a que estão submetidas as rochas drenadas pela bacia do rio Madeira, os valores das razões Th/Co, Th/Pb, Th/Yb, Al/Pb, Zr/Co e a composição isotópica de Pb indicam fontes distintas para os sedimentos de fundo estudados. Os sedimentos do rio Madeira são provenientes, principalmente, de rochas máficas, enquanto que os sedimentos de seus tributários têm como fonte essencialmente rochas félsicas.This study reports the granulometric, mineralogic and chemical analyses, including Pb isotope, carried out on the bottom sediments of the Madeira River, whose headwaters are in the Andes Mountain, and its tributaries that come from the cratonic region, in order to investigate the compositional variation of the sediments transported by the major rivers of the Amazon. The analytical data show that the bottom sediments of the Madeira River have

All Prime Contract Awards by State or Country, Place, and Contractor. Part 18 (Elmo Texas-San Saba Texas)

Science.gov (United States)

1990-01-01

on1 C> up0) 11 ca (-4N4 tax to "I toN >- >- (ao ro Y t ’C/ ACCA #IN ION to4 1,1 4100M I(-4 0 II Z £22 ( xz22 x2222 xZzz x Z x Z x Z x Z a (00 W 022* 02...0 OLU -IL 0 - I >0 ɛ 0 330 L’) I’ it1 0 0 (00 00 oleI3 < ifC’ F3 - r-CP,-’- - r--- in)-I -4N I (S0 M)-4 P.3) NNcq ’) to( M .N .4 0a 343 <’) 3it n-4

Work climate and the mediating role of workplace bullying related to job performance, job satisfaction, and work ability: A study among hospital nurses.

Science.gov (United States)

Olsen, Espen; Bjaalid, Gunhild; Mikkelsen, Aslaug

2017-11-01

To increase understanding of workplace bullying and its relation to work climate and different outcomes among nurses. Examine a proposed bullying model including both job resource and job demands, as well as nurse outcomes reflected in job performance, job satisfaction, and work ability. Workplace bullying has been identified as some of the most damaging mechanisms in workplace settings. It is important to increase understanding of workplace bullying in relation to work climate and different outcomes among nurses. This study adopted a cross-sectional web based survey design. A sample of 2946 Registered Nurses from four public Norwegian hospitals were collected during October 2014. We analysed data using descriptive statistics, correlations, Cronbach's alpa, confirmatory factor analyses, and structural equation modelling. The majority of work climate characteristics confirmed to influence workplace bullying, and additionally had direct influence on nurse outcomes; job performance, job satisfaction, and work ability. Bullying had a mediational role between most of the work climate dimensions and nurse outcomes. This study increases our understanding of organizational antecedent of bullying among nurses. Workplace bullying among nurses functions as a mediator between the majority of work climate dimensions and outcomes related to job satisfaction and work ability. Strategies to reduce bullying should look at the study finding and specifically job resources and job demands that influence bullying and nurse outcomes. © 2017 John Wiley & Sons Ltd.

El maestro José Francisco Socarrás. Biografía, recuerdos y recuentos!

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Guillermo Sánchez Medina

1996-04-01

Full Text Available

“Siempre que se escribe de la historia
de un hombre, quedan hechos incógnitos”

“Quien escribe historia y participa en ella no está
exento de subjetividades y parcializaciones”

Palabras introductorias
Para mí es un honor y una gratificación íntima el ser yo quien hoy se dirige a ustedes como coordinador de este homenaje. A todos los presentes les agradezco su presencia. En nombre de la familia Socarrás hago entrega oficial del bello óleo, del maestro Leonel Torres residente en USA. Lamento que por motivos ajenos a mi voluntad no se pueda entregar el libro de la Bio-grafía del Maestro Socarrás. En el mes de febrero próximo saldrá editado por la Universidad Pedagógica y Tecnológica de Colombia en Tunja, gracias también a la Academia Boyacense de Historia y a su cabeza el Doctor Javier Ocampo Lópcz. Espero poder ofrecer la obra en un futuro próximo, quien le interese puede comunicarse con la Secretaría de la Academia Nacional de Medicina.

José Francisco Socarrás nació en Valledupar (Cesar el martes 5 de noviembre de 1907 y murió en Bogotá el jueves 23 de marzo de 1995. (2

Etimología del apellido Socarrás.
Genealogía e historiografía

Etimológicamente el apellido Socarrás proviene del árabe: “soco” y “ras”; soco: plaza de mercado o plaza principal; y ras: cabeza. Lo que significa cabeza de la plaza principal o mercado.

El apellido, relata el profesor José Francisco Socarrás, viene por Evaristo Socarrás, proveniente de una población importante de Coro, Venezuela, quien se casó con Josefa Meriño en Riohacha y por segunda vez en La Paz, una población cercana a Valledupar.

Su padre fue el General Sabas Socarrás, quien peleó en los tres años de guerra civil a principios de

Sabaye Kashani’s Imitations of Ferdowsi’s Shahnameh in Khodavandnameh

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hr nafar

2012-11-01

Full Text Available Khodavandnameh book of poetry has been written by Fathali Khan Sabaye Kashani, the Persian poet of the Literary Restoration School in late twelfth and early thirteenth century. This religious epic which consists of 12000 verses has been composed as an imitation of Ferdowsi’s Shahnameh for describing the life of Prophet of Islam, his miracles and the battles of Imam Ali. Composing this book of poems, the poet has borrowed the words and expressions of Shahnameh. By manipulating the expressions of Shahnameh, the poet sometimes coins new expressions. He has used the marvelous and bombastic language of Shahnameh (Khorasani style which was the aim of Restoration poets for reviving the ancient language and stopping the deterioration of language. The composer of Khodavandnameh has not shown any innovation in creating the imagery (like metaphor and simile and he has used the imagery of Shahnameh. This article tries to explain Saba’s imitations of Ferdowsi via mentioning a number of examples in the fields of vocabulary, syntax, imagery (metaphor and simile, expression, idioms etc.

LA ACTUACIÓN DEL INSTITUTO NACIONAL DE COLONIZACIÓN EN EL MUNICIPIO DE HELLÍN (ALBACETE

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Gregorio Canales Martínez

1993-01-01

Full Text Available A mediados de la década de los cincuenta de la centuria actual, el Estado declara el Canal de Riegos de Hellín, en la provincia de Albacete, de alto interés nacional para la colonización agrícola. Para la puesta en riego se contó con una concesión de caudales del río Mundo de 1.000 l/s, así como del alumbramiento de aguas hipogeas. Con ello se pretendía paliar la crisis económica por la que atrave- saba el municipio hellinero, derivada de la ruina de la tradicional industria textil ligada al aprovechamiento del esparto. A partir de entonces se inicia una importante transformación del espacio mediante la distribución de 1.755 ha a unos doscientos colonos, que se agrupan en tres poblados rurales de nueva construcción: Nava de Campana, Mingogil y Cañada de Agra. El desarrollo y los pormenores de esta labor colonizadora son abordados en esta monografía.

National Uranium Resource Evaluation Program. Hydrogeochemical and stream sediment pilot survey of Llano area, Texas

International Nuclear Information System (INIS)

Nichols, C.E.; Kane, V.E.; Minkin, S.C.; Cagle, G.W.

1976-01-01

A pilot geochemical survey of the Llano, Texas, area was conducted during February and March 1976. The purpose of this work was to prepare for a subsequent reconnaissance geochemical survey of uranium in Central Texas. Stream sediment, stream water, well water, and plant ash from five geologic areas were analyzed in the laboratory for approximately 25 parameters. Examples of anomalous values in stream sediment and stream water indicate the usefulness of both sample types in identifying anomalies at a regional reconnaissance-scale station spacing of approximately 5 km (3 mi). Groundwater samples, which generally best indicate the geochemistry of formations at depth in a survey of this type, represent another important tool in detecting uranium mineralization. Anomalies in San Saba County are associated with the Marble Falls-Smithwich Formations and the Strawn Series (Pennsylvanian), the Houy Formation (Devonian and lower Mississippian), and the Hickory Sandstone Member of the Riley Formation (Cambrian). In Burnet County anomalous values are due to the influence of the Valley Spring Formation (Precambrian); and in Blanco County anomalies are found associated with the Riley Formation

Revista de tesis

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Facultad de Medicina Revista

1945-06-01

Full Text Available Contribución al estudio y tratamiento de los epiteliomas cutáneos por medio de las irradiaciones. Tesis de grado aceptada con "Mención Honorífica". 1944. - Presentada por Julio Barrera Saba / Metabolismo basal en la pubertad. Tesis de grado aceptada con "Mención Honorífica". 1944. - Presentada por Manuel Antonio Sanclemente O. / Estudios radiológicos de los escleromas de las vías aereas superiores. Tesis de grado declarada "Meritoria". 1944. - Presentada por Jorge Amorocho Carreño / Anotaciones sobre el estado sanitario, higiene y patología médica de la provincia de García Rovira. Tesis de grado 1944. Presentada por Germán Rodríguez B. / Tratamiento del prolapso genital por la operación de Fothergill. Tesis de grado 1944. - Presentada por Mario Sorzano Jiménez / La adrenalinemia en el embarazo y en el puerperio normales. Tesis de grado 1944. - Presentada por Rubén Fernández.

STRATEGI PENGENTASAN KEMISKINAN DALAM PERSPEKTIF ISLAM

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Sri Budi Cantika

2013-07-01

Full Text Available Islamic perspective views poverty as a result of several structural reasons, namely environmental damage due to human activity (Surah Ar Rum: 41; ignorance and the miserliness of the wealthy (Surah Al ‘Imran: 180; tyranny, exploitation, and oppression of some people over others (Surah At-Tawbah: 34; political, bureaucracy, and economic power concentration in one hand (Surah Al Qasas; 1-88; poverty arising from external factors such as natural disaster or civil wars that drastically changed the rich become poor (Surah Saba ‘: 14-15. Islam proposes some strategies in order to reduce poverty which covers: 1 Promoting economic growth that benefits to the wider community (pro-poor growth; 2 Encouraging the construction of national budget which protect majority of people (pro-poor budgeting; 3 Assisting infrastructure development that aids many people (pro-poor infrastructure; 4 Establishing proper basic public services in favor of the broader community (pro-poor public services; and 5 Pushing equity and income distribution policies that prioritize the poor (pro-poor income distribution.

Construcción y calibración de un penetrómetro de impacto para medir los efectos del senderismo

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Valentina Toledo Bruzual

2016-01-01

Full Text Available Se diseñó un penetrómetro de impacto, en forma mecánica, para evaluar la resistencia mecánica en los suelos, producida por la presión de las pisadas humanas, en dos senderos: Sabas Nieves y Los Venados, del Parque Nacional Warairo Repano (El Ávila, Venezuela. El aparato tiene la ventaja de ser ligero y por tanto, portátil, ya que solo pesa 1.2 kg. Es preciso, validado estadísticamente y práctico como lo expone el protocolo de uso. Los resultados mostraron que el uso del prototipo en campo, es sensible para detectar diferencias en la resistencia mecánica del suelo, en diferentes coberturas vegetales: Sabana de montaña y Bosque veranero, y con distintos porcentajes de materia orgánica. El equipo es confiable en cuanto a la repetibilidad de las mediciones y viable en los trabajos de investigación que se requiera realizar sobre la compactación del suelo, en los diferentes senderos del Parque Nacional Waraira Repano.

Respiratory medication used in COPD patients from seven Latin American countries: the LASSYC study

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Casas A

2018-05-01

Full Text Available Alejandro Casas,1 Maria Montes de Oca,2 Ana MB Menezes,3 Fernando C Wehrmeister,3 Maria Victorina Lopez Varela,4 Laura Mendoza,5 Larissa Ramírez,6 Marc Miravitlles7 On behalf of the LASSYC team 1Fundación Neumológica Colombiana, Universidad del Rosario, Bogotá, Colombia; 2Universidad Central de Venezuela, Caracas, Venezuela; 3Federal University of Pelotas, Pelotas, Brazil; 4Universidad de la República, Montevideo, Uruguay; 5Hospital Clínico Universidad de Chile, Santiago de Chile, Chile; 6AstraZeneca, San José, Costa Rica; 7Department of Pneumology, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades Respiratorias (CIBERES, Barcelona, Spain Background: Limited information is available regarding medication use in COPD patients from Latin America. This study evaluated the type of medication used and the adherence to different inhaled treatments in stable COPD patients from the Latin American region.Methods: This was an observational, cross-sectional, multinational, and multicenter study in COPD patients attended by specialist doctors from seven Latin American countries. Adherence to inhaled therapy was assessed using the Test of Adherence to Inhalers (TAI questionnaire. The type of medication was assessed as: short-acting β-agonist (SABA or short-acting muscarinic antagonist (SAMA only, long-acting muscarinic antagonist (LAMA, long-acting β-agonist (LABA, LABA/LAMA, inhaled corticosteroid (ICS, ICS/LABA, ICS/LAMA/LABA, or other.Results: In total, 795 patients were included (59.6% male, with a mean age of 69.5±8.7 years and post-bronchodilator FEV1 of 50.0%±18.6%. The ICS/LAMA/LABA (32.9% and ICS/LABA (27.7% combinations were the most common medications used, followed by LABA/LAMA (11.3%, SABA or SAMA (7.9%, LABA (6.4%, LAMA (5.8%, and ICS (4.3%. The types of medication most commonly used in each Global Initiative for Chronic Obstructive Lung Disease (GOLD 2013 category were ICS/LABA (A: 32.7%; B: 19.8%; C: 25.7%; D: 28.2% and

Comparison of Salivary pH, Buffering Capacity and Alkaline Phosphatase in Smokers and Healthy Non-Smokers: Retrospective cohort study.

Science.gov (United States)

Ahmadi-Motamayel, Fatemeh; Falsafi, Parisa; Goodarzi, Mohammad T; Poorolajal, Jalal

2016-08-01

Saliva contains alkaline phosphatase (ALP)-a key intracellular enzyme related to destructive processes and cellular damage-and has buffering capacity (BC) against acids due to the presence of bicarbonate and phosphate ions. Smoking may have deleterious effects on the oral environment due to pH changes which can affect ALP activity. This study aimed to evaluate the salivary pH, BC and ALP activity of male smokers and healthy non-smokers. This retrospective cohort study took place between August 2012 and December 2013. A total of 251 healthy male non-smokers and 259 male smokers from Hamadan, Iran, were selected. Unstimulated whole saliva was collected from each participant and pH and BC were determined using a pH meter. Salivary enzymes were measured by spectrophotometric assay. Mean salivary pH (7.42 ± 0.48 and 7.52 ± 0.43, respectively; P = 0.018) and BC (3.41 ± 0.54 and 4.17 ± 0.71; P = 0.001) was significantly lower in smokers compared to non-smokers. Mean ALP levels were 49.58 ± 23.33 IU/L among smokers and 55.11 ± 27.85 IU/L among non-smokers (P = 0.015). Significantly lower pH, BC and ALP levels were observed among smokers in comparison to a healthy control group. These salivary alterations could potentially be utilised as biochemical markers for the evaluation of oral tissue function and side-effects among smokers. Further longitudinal studies are recommended to evaluate the effects of smoking on salivary components.

A Novel Assay for Easy and Rapid Quantification of Helicobacter pylori Adhesion.

Science.gov (United States)

Skindersoe, Mette E; Rasmussen, Lone; Andersen, Leif P; Krogfelt, Karen A

2015-06-01

Reducing adhesion of Helicobacter pylori to gastric epithelial cells could be a new way to counteract infections with this organism. We here present a novel method for quantification of Helicobacter pylori adhesion to cells. Helicobacter pylori is allowed to adhere to AGS or MKN45g cells in a 96-well microtiter plate. Then wells are added saponin, which lyses the cells without affecting the bacteria. After addition of alamarBlue(®) (resazurin) and 1- to 2-hour incubation, fluorescence measurements can be used to quantify the number of adherent bacteria. By use of the method, we demonstrate that adhesion of both a sabA and babA deletion mutant of H. pylori is significantly reduced compared to the wild type. The method offers a number of applications and may be used to compare the adherence potential of different strains of H. pylori to either cells or different materials or to screen for potential anti-adhesive compounds. The results presented here suggest that this easy and reproducible assay is well suited for quantitative investigation of H. pylori adhesion. © 2015 John Wiley & Sons Ltd.

Vaccine-associated feline sarcoma: current perspectives

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Saba CF

2017-01-01

Full Text Available Corey F Saba Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA Abstract: Feline injection site sarcomas (FISS; also known as vaccine-associated sarcomas have been recognized for >20 years. Although uncommon, these tumors are iatrogenic, and vaccination against rabies and feline leukemia virus is perhaps the most common inciting cause. The exact etiopathogenesis is unknown, but it is widely accepted that inflammation induced by vaccines or other injections likely plays a critical role in tumor development. Injection site sarcomas are extremely locally invasive. Multimodal therapy, incorporating combinations of surgery, radiation therapy, and sometimes chemotherapy or immunotherapy, is recommended. However, tumor recurrences are common even with aggressive treatment, and many cats with FISS ultimately succumb to this devastating disease. While vaccination protocols play an important role in the management and control of infectious disease, veterinarians must be diligent in following established vaccination guidelines to minimize individual patient risk of FISS development. Early tumor detection and client education are also vital in the successful treatment of FISS. Keywords: injection site sarcoma, cat, cancer, oncology

Further validation and definition of the psychometric properties of the Asthma Impact Survey.

Science.gov (United States)

Schatz, Michael; Zeiger, Robert S; Yang, Su-Jau; Chen, Wansu; Kosinski, Mark

2011-07-01

The Asthma Impact Survey (AIS-6) is a brief disease-specific quality-of-life instrument with limited published validation data. To obtain additional validation data and psychometric properties of the AIS-6. In November, 2007, patients with persistent asthma were mailed a survey that included the AIS-6, the mini-Asthma Quality of Life Questionnaire (mAQLQ), and the Asthma Control Test (ACT). Follow-up surveys were sent in April, July, and October 2008. Year 2008 exacerbations and short-acting β-agonist (SABA) dispensings were captured from administrative data. A total of 2680 patients had complete baseline survey data. Criterion validity was demonstrated by the strong correlations of the AIS-6 with the mAQLQ (r = -0.84 to -0.86); construct validity by significant relationships (P validity by significant relationships (P reliability (intraclass correlation coefficient = 0.86-0.91) were also demonstrated. The AIS-6 demonstrated good psychometric properties in a large independent sample and could be used to assess asthma-specific quality of life in clinical practice and clinical research. Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes

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Bosnic-Anticevich S

2016-12-01

incidence rate ratio (IRR comparing the rate of exacerbations between study cohorts. A secondary outcome compared average daily use of short-acting beta agonist (SABA. Results: The final study sample contained 8,225 patients in each cohort (mean age 67 [SD, 10], 57% males, 37% current smokers. Patients in the similar-devices cohort had a lower rate of exacerbations compared with those in the mixed-devices cohort (adjusted IRR 0.82, 95% confidence interval [CI] 0.80–0.84 and were less likely to be in a higher-dose SABA group (adjusted proportional odds ratio 0.54, 95% CI 0.51–0.57. Conclusion: COPD patients who were prescribed one or more additional inhaler devices requiring similar inhalation techniques to their previous device(s showed better outcomes than those who were prescribed devices requiring different techniques. Keywords: chronic obstructive pulmonary disease, inhalation technique, exacerbations, inhaler devices, observational, matched cohort

Ascertainment of Customs and Personal Laws in Medieval Italy from the Lombard Kingdom to the Communes

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Claudia Storti

2016-01-01

Full Text Available The medieval systems of law in Italy and Europe have been proposed as a sort of virtual laboratory to deal with the issue of ensuring that the principle of equality in the rule of law be compatible with the recognition of indigenous peoples’ customs. The legal framework of the medieval communes sought to strike a balance between the general interest in having legal certainty and uniformity with the citizens’ interest in ruling their family life and economic assets according to their cultural and social values. Up until the 14th century, in Lombardy an individual’s legal status, family and inheritance continued to be ruled according to the customs of the individual’s natio, be they Lombard or Roman. The ascertainment of customs is an arduous task, as oral customs are fluid and vary from place to place and from family to family. For this reason, in the Middle Ages ascertainment was always entrusted to judges and legal experts (sapientes. Until a few decades ago, recognising and enforcing customs was mostly unthinkable due to legal positivism and the principle of equality. Now, however, the limits of the principle of legal equality are well known: »Legal positivism was not able to abolish status« (G. Alpa. The recognition of »legal Indigenous status« provides continuity between the past (the Middle Ages and present (Indigenous Peoples Basic Law. Just as in the past, when living according to a given natio’s laws and customs did not mean self-government, so today the enforcement of an indigenous peoples’ basic law should not undermine the sovereignty of the State.

FY 1999 report on the survey of the history/inheritance of industrial technology. Survey of originality and creativity in electric/electronic technology in the Japanese industry; 1999 nendo sangyo gijutsu rekishi keisho chosa hokokusho. Kokunai sangyo no denki densi gijutsu no dokusosei to sozosei no chosa hen

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

For the purpose of clarifying the course of promotion of the original/creative future R and D and contributing to selection of technical themes and working-out of developmental methods, the paper conducted a survey of listening to Mr. S. Saba, Mr. Y. Hirose and Mr. K. Fujimori who are honorary members of the Institute of Electrical Engineers of Japan. For the survey, the following points were taken notice of: to fully make prior preparation; to supplement/prove what was presented and to have a lot of data by which objectivity was given to what was presented; to keep a balance between 'reminiscences' which are useful for completion of the details and the details focused; to establish the analysis method of the details of the listening; to be careful to make analysis of technology and persons so that the listening survey can be connected to the systematical arrangement; to look for 'good listeners.' As a result of the listening survey, a lot of the suggestive results seemed to be obtained in terms of the innovation of the industrial technology that has been shouldering the development of Japan and the originality/creativity seen in the innovation. (NEDO)

Community change within a Caribbean coral reef Marine Protected Area following two decades of local management.

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Mae M Noble

Full Text Available Structural change in both the habitat and reef-associated fish assemblages within spatially managed coral reefs can provide key insights into the benefits and limitations of Marine Protected Areas (MPAs. While MPA zoning effects on particular target species are well reported, we are yet to fully resolve the various affects of spatial management on the structure of coral reef communities over decadal time scales. Here, we document mixed affects of MPA zoning on fish density, biomass and species richness over the 21 years since establishment of the Saba Marine Park (SMP. Although we found significantly greater biomass and species richness of reef-associated fishes within shallow habitats (5 meters depth closed to fishing, this did not hold for deeper (15 m habitats, and there was a widespread decline (38% decrease in live hard coral cover and a 68% loss of carnivorous reef fishes across all zones of the SMP from the 1990s to 2008. Given the importance of live coral for the maintenance and replenishment of reef fishes, and the likely role of chronic disturbance in driving coral decline across the region, we explore how local spatial management can help protect coral reef ecosystems within the context of large-scale environmental pressures and disturbances outside the purview of local MPA management.

Pharmacogenetics of the β2-Adrenergic Receptor Gene

Science.gov (United States)

Ortega, Victor E.; Hawkins, Gregory A.; Peters, Stephen P.; Bleecker, Eugene R.

2009-01-01

Asthma is a complex genetic disease with multiple genetic and environmental determinants contributing to the observed variability in response to common anti-asthma therapies. Asthma pharmacogenetic research has focused on multiple candidate genes including the β2-adrenergic receptor gene (ADRβ2) and its effect on individual responses to beta agonist therapy. At present, knowledge about the effects of ADRβ2 variation on therapeutic responses is evolving and should not alter current Asthma Guideline approaches consisting of the use of short acting beta agonists for as-needed symptom based therapy and the use of a regular long-acting beta agonist in combination with inhaled corticosteroid therapy for optimal control of asthma symptoms in those asthmatics who are not controlled on inhaled corticosteroid alone. This approach is based upon studies showing a consistent pharmacogenetic response to regular use of short acting beta agonists (SABA) and less consistent findings in studies evaluating long acting beta agonist (LABA). While emerging pharmacogenetic studies are provocative and should lead to functional approaches, conflicting data with responses to LABA therapy may be caused by factors that include small sample sizes of study populations and differences in experimental design that may limit the conclusions that may be drawn from these clinical trials at the present time. PMID:17996583

Inscribing Authority: Female Title Bearers in Jewish Inscriptions

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Carrie Duncan

2012-02-01

Full Text Available This paper investigates representations of gender in the material culture of the ancient synagogue. The pertinent data are numerous dedicatory and funerary inscriptions linking individual Jews, men and women, with titles seemingly associated with leadership in Late Antique synagogues (ca. 200–600 CE. Bernadette Brooten’s influential 1982 monograph argued against the prevailing tendency to characterize these titles as indications of power, authority, and responsibility when associated with men but as meaningless flattery when applied to women. She suggests that synagogue titles denote power, authority and responsibility on all title bearers equally, both men and women. I question the continued utility of proffering female title-holders as enumerable examples of powerful women rescued from their forgotten place in history. Using theoretical insights developed by historians Elizabeth Clark and Gabrielle Spiegel, this paper will engage a comparative analysis with the work of Riet van Bremen and Saba Mahmood to develop new methods of conceptualizing women’s authority in early Jewish communities. I propose that viewing women’s synagogue titles as culturally constructed representations allows for a fruitful inquiry into how women’s titles were used by male-dominated synagogue communities in their self-articulation and public presentation of Judaism.

Protein translation and cell death: the role of rare tRNAs in biofilm formation and in activating dormant phage killer genes.

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Rodolfo García-Contreras

2008-06-01

Full Text Available We discovered previously that the small Escherichia coli proteins Hha (hemolysin expression modulating protein and the adjacent, poorly-characterized YbaJ are important for biofilm formation; however, their roles have been nebulous. Biofilms are intricate communities in which cell signaling often converts single cells into primitive tissues. Here we show that Hha decreases biofilm formation dramatically by repressing the transcription of rare codon tRNAs which serves to inhibit fimbriae production and by repressing to some extent transcription of fimbrial genes fimA and ihfA. In vivo binding studies show Hha binds to the rare codon tRNAs argU, ileX, ileY, and proL and to two prophage clusters D1P12 and CP4-57. Real-time PCR corroborated that Hha represses argU and proL, and Hha type I fimbriae repression is abolished by the addition of extra copies of argU, ileY, and proL. The repression of transcription of rare codon tRNAs by Hha also leads to cell lysis and biofilm dispersal due to activation of prophage lytic genes rzpD, yfjZ, appY, and alpA and due to induction of ClpP/ClpX proteases which activate toxins by degrading antitoxins. YbaJ serves to mediate the toxicity of Hha. Hence, we have identified that a single protein (Hha can control biofilm formation by limiting fimbriae production as well as by controlling cell death. The mechanism used by Hha is the control of translation via the availability of rare codon tRNAs which reduces fimbriae production and activates prophage lytic genes. Therefore, Hha acts as a toxin in conjunction with co-transcribed YbaJ (TomB that attenuates Hha toxicity.

Helicobacter pylori genetic diversification in the Mongolian gerbil model.

Science.gov (United States)

Beckett, Amber C; Loh, John T; Chopra, Abha; Leary, Shay; Lin, Aung Soe; McDonnell, Wyatt J; Dixon, Beverly R E A; Noto, Jennifer M; Israel, Dawn A; Peek, Richard M; Mallal, Simon; Algood, Holly M Scott; Cover, Timothy L

2018-01-01

Helicobacter pylori requires genetic agility to infect new hosts and establish long-term colonization of changing gastric environments. In this study, we analyzed H. pylori genetic adaptation in the Mongolian gerbil model. This model is of particular interest because H. pylori -infected gerbils develop a high level of gastric inflammation and often develop gastric adenocarcinoma or gastric ulceration. We analyzed the whole genome sequences of H. pylori strains cultured from experimentally infected gerbils, in comparison to the genome sequence of the input strain. The mean annualized single nucleotide polymorphism (SNP) rate per site was 1.5e -5 , which is similar to the rates detected previously in H. pylori- infected humans. Many of the mutations occurred within or upstream of genes associated with iron-related functions ( fur , tonB1 , fecA2 , fecA3 , and frpB3 ) or encoding outer membrane proteins ( alpA, oipA, fecA2, fecA3, frpB3 and cagY ). Most of the SNPs within coding regions (86%) were non-synonymous mutations. Several deletion or insertion mutations led to disruption of open reading frames, suggesting that the corresponding gene products are not required or are deleterious during chronic H. pylori colonization of the gerbil stomach. Five variants (three SNPs and two deletions) were detected in isolates from multiple animals, which suggests that these mutations conferred a selective advantage. One of the mutations (FurR88H) detected in isolates from multiple animals was previously shown to confer increased resistance to oxidative stress, and we now show that this SNP also confers a survival advantage when H. pylori is co-cultured with neutrophils. Collectively, these analyses allow the identification of mutations that are positively selected during H. pylori colonization of the gerbil model.

Prototypic Development and Evaluation of a Medium Format Metric Camera

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Hastedt, H.; Rofallski, R.; Luhmann, T.; Rosenbauer, R.; Ochsner, D.; Rieke-Zapp, D.

2018-05-01

Engineering applications require high-precision 3D measurement techniques for object sizes that vary between small volumes (2-3 m in each direction) and large volumes (around 20 x 20 x 1-10 m). The requested precision in object space (1σ RMS) is defined to be within 0.1-0.2 mm for large volumes and less than 0.01 mm for small volumes. In particular, focussing large volume applications the availability of a metric camera would have different advantages for several reasons: 1) high-quality optical components and stabilisations allow for a stable interior geometry of the camera itself, 2) a stable geometry leads to a stable interior orientation that enables for an a priori camera calibration, 3) a higher resulting precision can be expected. With this article the development and accuracy evaluation of a new metric camera, the ALPA 12 FPS add|metric will be presented. Its general accuracy potential is tested against calibrated lengths in a small volume test environment based on the German Guideline VDI/VDE 2634.1 (2002). Maximum length measurement errors of less than 0.025 mm are achieved with different scenarios having been tested. The accuracy potential for large volumes is estimated within a feasibility study on the application of photogrammetric measurements for the deformation estimation on a large wooden shipwreck in the German Maritime Museum. An accuracy of 0.2 mm-0.4 mm is reached for a length of 28 m (given by a distance from a lasertracker network measurement). All analyses have proven high stabilities of the interior orientation of the camera and indicate the applicability for a priori camera calibration for subsequent 3D measurements.

PROTOTYPIC DEVELOPMENT AND EVALUATION OF A MEDIUM FORMAT METRIC CAMERA

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H. Hastedt

2018-05-01

Full Text Available Engineering applications require high-precision 3D measurement techniques for object sizes that vary between small volumes (2–3 m in each direction and large volumes (around 20 x 20 x 1–10 m. The requested precision in object space (1σ RMS is defined to be within 0.1–0.2 mm for large volumes and less than 0.01 mm for small volumes. In particular, focussing large volume applications the availability of a metric camera would have different advantages for several reasons: 1 high-quality optical components and stabilisations allow for a stable interior geometry of the camera itself, 2 a stable geometry leads to a stable interior orientation that enables for an a priori camera calibration, 3 a higher resulting precision can be expected. With this article the development and accuracy evaluation of a new metric camera, the ALPA 12 FPS add|metric will be presented. Its general accuracy potential is tested against calibrated lengths in a small volume test environment based on the German Guideline VDI/VDE 2634.1 (2002. Maximum length measurement errors of less than 0.025 mm are achieved with different scenarios having been tested. The accuracy potential for large volumes is estimated within a feasibility study on the application of photogrammetric measurements for the deformation estimation on a large wooden shipwreck in the German Maritime Museum. An accuracy of 0.2 mm–0.4 mm is reached for a length of 28 m (given by a distance from a lasertracker network measurement. All analyses have proven high stabilities of the interior orientation of the camera and indicate the applicability for a priori camera calibration for subsequent 3D measurements.

Regulation of the Synthesis of the Angucyclinone Antibiotic Alpomycin in Streptomyces ambofaciens by the Autoregulator Receptor AlpZ and Its Specific Ligand▿

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Bunet, Robert; Mendes, Marta V.; Rouhier, Nicolas; Pang, Xiuhua; Hotel, Laurence; Leblond, Pierre; Aigle, Bertrand

2008-01-01

Streptomyces ambofaciens produces an orange pigment and the antibiotic alpomycin, both of which are products of a type II polyketide synthase gene cluster identified in each of the terminal inverted repeats of the linear chromosome. Five regulatory genes encoding Streptomyces antibiotic regulatory proteins (alpV, previously shown to be an essential activator gene; alpT; and alpU) and TetR family receptors (alpZ and alpW) were detected in this cluster. Here, we demonstrate that AlpZ, which shows high similarity to γ-butyrolactone receptors, is at the top of a pathway-specific regulatory hierarchy that prevents synthesis of the alp polyketide products. Deletion of the two copies of alpZ resulted in the precocious production of both alpomycin and the orange pigment, suggesting a repressor role for AlpZ. Consistent with this, expression of the five alp-located regulatory genes and of two representative biosynthetic structural genes (alpA and alpR) was induced earlier in the alpZ deletion strain. Furthermore, recombinant AlpZ was shown to bind to specific DNA sequences within the promoter regions of alpZ, alpV, and alpXW, suggesting direct transcriptional control of these genes by AlpZ. Analysis of solvent extracts of S. ambofaciens cultures identified the existence of a factor which induces precocious production of alpomycin and pigment in the wild-type strain and which can disrupt the binding of AlpZ to its DNA targets. This activity is reminiscent of γ-butyrolactone-type molecules. However, the AlpZ-interacting molecule(s) was shown to be resistant to an alkali treatment capable of inactivating γ-butyrolactones, suggesting that the AlpZ ligand(s) does not possess a lactone functional group. PMID:18296523

Regulation of the synthesis of the angucyclinone antibiotic alpomycin in Streptomyces ambofaciens by the autoregulator receptor AlpZ and its specific ligand.

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Bunet, Robert; Mendes, Marta V; Rouhier, Nicolas; Pang, Xiuhua; Hotel, Laurence; Leblond, Pierre; Aigle, Bertrand

2008-05-01

Streptomyces ambofaciens produces an orange pigment and the antibiotic alpomycin, both of which are products of a type II polyketide synthase gene cluster identified in each of the terminal inverted repeats of the linear chromosome. Five regulatory genes encoding Streptomyces antibiotic regulatory proteins (alpV, previously shown to be an essential activator gene; alpT; and alpU) and TetR family receptors (alpZ and alpW) were detected in this cluster. Here, we demonstrate that AlpZ, which shows high similarity to gamma-butyrolactone receptors, is at the top of a pathway-specific regulatory hierarchy that prevents synthesis of the alp polyketide products. Deletion of the two copies of alpZ resulted in the precocious production of both alpomycin and the orange pigment, suggesting a repressor role for AlpZ. Consistent with this, expression of the five alp-located regulatory genes and of two representative biosynthetic structural genes (alpA and alpR) was induced earlier in the alpZ deletion strain. Furthermore, recombinant AlpZ was shown to bind to specific DNA sequences within the promoter regions of alpZ, alpV, and alpXW, suggesting direct transcriptional control of these genes by AlpZ. Analysis of solvent extracts of S. ambofaciens cultures identified the existence of a factor which induces precocious production of alpomycin and pigment in the wild-type strain and which can disrupt the binding of AlpZ to its DNA targets. This activity is reminiscent of gamma-butyrolactone-type molecules. However, the AlpZ-interacting molecule(s) was shown to be resistant to an alkali treatment capable of inactivating gamma-butyrolactones, suggesting that the AlpZ ligand(s) does not possess a lactone functional group.

STUDI TENTANG PEMROSESAN TEPUNG SORGUM TERFOSFORILASI DAN APLIKASINYA PADA BERBAGAI ADONAN PASTRI

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Ummi Rohajatien

2012-08-01

Full Text Available Sorghum is a potential alternative food source to be developed. The objective of the research is. (1 to know the effects of the treatment of STTP concen­tra­tion and duration of phosphorylation process to functional properties of sorghum flour; and (2 to know the comparison on both the physical and organoleptic quality of pastry product using basic material of phosphorylated sorghum and wheat flour. The research uses factorial randomized block design with 2 factors. T-Test is used to know both comparison on physical and organoleptic quality of pastry product by using basic material of phosphorylated sorghum and wheat flour. The result of T-test to the physical quality parameters of cake and pancake (cutting power, texture and color lightness was significantly different for the alpha 0,05. On the other hand, organoleptic quality parameters (appearance, taste, flavor, smoothness, softness and color were not significantly different. In addition, for cookies physical quality para­meters (broken power, texture, and color were significantly different. On the contrary, for organoleptic quality parameters, they were not significantly different. Sorgum merupakan sumber makanan alternatif sangat potensial untuk di­kembangkan. Penelitian ini bertujuan: (1 mengetahui pengaruh perlakuan konsentrasi STTP dan lamanya proses fosforilasi pada sifat fungsional pada tepung sorgum; dan (2 me­ngetahui perbandingan kedua kualitas organopleptik dan fisik produk pastri dengan menggunakan bahan dasar tepung terigu sorgum terfosforilasi. Penelitian meng­gunakan rancangan blok acak faktorial dengan 2 faktor. T-test digunakan untuk mengetahui kedua perbandingan pada sifat fisik dan organoleptik produk pastri dengan menggunakan sifat dasar tepung terigu dan sorgum terfosforilasi. Hasil dari T-test pada parameter kualitas fisik cake dan kue dadar berbeda secara nyata pada alpa 0,05. Parameter kualitas organoleptik tidak berbeda nyata. Parameter kualitas fisik cookies

Community Change within a Caribbean Coral Reef Marine Protected Area following Two Decades of Local Management

KAUST Repository

Noble, Mae M.

2013-01-14

Structural change in both the habitat and reef-associated fish assemblages within spatially managed coral reefs can provide key insights into the benefits and limitations of Marine Protected Areas (MPAs). While MPA zoning effects on particular target species are well reported, we are yet to fully resolve the various affects of spatial management on the structure of coral reef communities over decadal time scales. Here, we document mixed affects of MPA zoning on fish density, biomass and species richness over the 21 years since establishment of the Saba Marine Park (SMP). Although we found significantly greater biomass and species richness of reef-associated fishes within shallow habitats (5 meters depth) closed to fishing, this did not hold for deeper (15 m) habitats, and there was a widespread decline (38% decrease) in live hard coral cover and a 68% loss of carnivorous reef fishes across all zones of the SMP from the 1990s to 2008. Given the importance of live coral for the maintenance and replenishment of reef fishes, and the likely role of chronic disturbance in driving coral decline across the region, we explore how local spatial management can help protect coral reef ecosystems within the context of large-scale environmental pressures and disturbances outside the purview of local MPA management. © 2013 Noble et al.

Chronic obstructive pulmonary disease associated with increased risk of bipolar disorder.

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Su, Vincent Yi-Fong; Hu, Li-Yu; Yeh, Chiu-Mei; Chiang, Huey-Ling; Shen, Cheng-Che; Chou, Kun-Ta; Chen, Tzeng-Ji; Lu, Ti; Tzeng, Cheng-Hwai; Liu, Chia-Jen

2017-05-01

Epidemiological studies have identified a trend in the development of depressive and anxiety disorders following a diagnosis of chronic obstructive pulmonary disease (COPD). However, the relationship between COPD and subsequent bipolar disorder remains unclear. From January 1, 2000, we identified adult patients with COPD from the Taiwan National Health Insurance Research Database. A nationwide population-based study was conducted; 46,778 COPD patients and 46,778 age-, sex-, and comorbidity-matched subjects between 2000 and 2011 were enrolled. The two cohorts were followed up till December 31, 2011 and observed for occurrence of bipolar disorder. We observed the COPD and comparison cohorts for 263,020 and 267,895 person-years, respectively, from 2000 to 2011. The incidence rate for bipolar disorder was 1.6/1000 person-years in the COPD cohort and 1.2/1000 person-years in the comparison cohort ( p bipolar disorder among the COPD patients was 1.42 (95% confidence interval [CI], 1.22-1.64; p bipolar disorder development (HR = 1.83, 95% CI = 1.25-2.69, p = 0.002). Other COPD medications were not associated with the risk of bipolar disorder development. The study results indicate that COPD may be an independent risk factor for the development of bipolar disorder. The regular use of SABAs might increase the risk of bipolar disorder in COPD patients.

Acetylated Rhamnogalacturonans from Immature Fruits of Abelmoschus esculentus Inhibit the Adhesion of Helicobacter pylori to Human Gastric Cells by Interaction with Outer Membrane Proteins

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Christian Thöle

2015-09-01

Full Text Available Polysaccharide containing extracts from immature fruits of okra (Abelmoschus esculentus are known to exhibit antiadhesive effects against bacterial adhesion of Helicobacter pylori (H. pylori to stomach tissue. The present study investigates structural and functional features of polymers responsible for this inhibition of bacterial attachment to host cells. Ammonium sulfate precipitation of an aqueous extract yielded two fractions at 60% and 90% saturation with significant antiadhesive effects against H. pylori, strain J99, (FE60% 68% ± 15%; FE90% 75% ± 11% inhibition rates after preincubation of the bacteria at 1 mg/mL. Sequential extraction of okra fruits yielded hot buffer soluble solids (HBSS with dose dependent antiadhesive effects against strain J99 and three clinical isolates. Preincubation of H. pylori with HBSS (1 mg/mL led to reduced binding to 3ʹ-sialyl lactose, sialylated Lea and Lex. A reduction of bacterial binding to ligands complementary to BabA and SabA was observed when bacteria were pretreated with FE90%. Structural analysis of the antiadhesive polysaccharides (molecular weight, monomer composition, linkage analysis, stereochemistry, and acetylation indicated the presence of acetylated rhamnogalacturonan-I polymers, decorated with short galactose side chains. Deacetylation of HBSS and FE90% resulted in loss of the antiadhesive activity, indicating esterification being a prerequisite for antiadhesive activity.

Encuesta a neumonólogos sobre el diagnóstico y tratamiento de EPOC Survey of chest physicians regarding copd diagnosis and treatment

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Martín L. Sívori

2004-04-01

encuestados indican la vacuna antigripal y el 91.4% la antineumocóccica. Según los encuestados el 37% de los pacientes continúan fumando. Nuestros especialistas utilizan pautas que están de acuerdo con las guías de diagnóstico y tratamiento. Como primera opción en el tratamiento crónico es muy utilizada la asociación de AC + BAAC y escasamente los CI y los BAAL.A survey on COPD diagnostic procedures, treatment and management was conducted in a group of 517 chest physicians randomized from a list of the 1121 affiliates to the Asociación Argentina de Medicina Respiratoria. One hundred eighty-seven responses were obtained (36.2% of the questionnaires mailed. They treat an average of 53.3 COPD patients every month. Twenty-four percent of them had mild, 41.8% moderate and 33.8% severe disease (GOLD criteria. Only clinical criteria for diagnosis of COPD, clinical criteria + spirometry (S, and clinical criteria + S + chest X ray were used by 2.9, 23.4 and 73.7% of responders, respectively. Seventy percent of responders believed that chronic asthma without bronchodilator response must be included in the COPD definition. Only 14.1% of responders performed S in every office visit. Cardiac function was assessed using clinical criteria, electrocardiogram and echocardiogram by 90.6, 80.6 and 73.8% of responders, respectively, while 98.3% stated that they trained most of their patients in the inhalation technique. Metered Dose Inhaled was the first option for bronchodilators administration (64.8% followed by nebulization (16.5%, dry powder inhalation (13.7% and oral administration (4.8%. First option for chronic therapy in severe COPD patients was the association of anticholinergic drug (AC + short acting b2-agonists (SABA (65.5%, AC alone (18.8%, long acting b2-agonists (LABA (9.7%, inhaled corticosteroids (IC (3.5% and SABA alone (2.8%. Corticosteroids and antibiotics were prescribed in severe COPD exacerbation by 92.5 and 70% of responders, respectively. First choice

Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps

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Östlund Ollie

2011-04-01

Full Text Available Abstract Background Adjusting medication for uncontrolled asthma involves selecting one of several options from the same or a higher treatment step outlined in asthma guidelines. We examined the relative benefit of introducing budesonide/formoterol (BUD/FORM maintenance and reliever therapy (Symbicort SMART® Turbuhaler® in patients previously prescribed treatments from Global Initiative for Asthma (GINA Steps 2, 3 or 4. Methods This is a post hoc analysis of the results of five large clinical trials (>12000 patients comparing BUD/FORM maintenance and reliever therapy with other treatments categorised by treatment step at study entry. Both current clinical asthma control during the last week of treatment and exacerbations during the study were examined. Results At each GINA treatment step, the proportion of patients achieving target levels of current clinical control were similar or higher with BUD/FORM maintenance and reliever therapy compared with the same or a higher fixed maintenance dose of inhaled corticosteroid/long-acting β2-agonist (ICS/LABA (plus short-acting β2-agonist [SABA] as reliever, and rates of exacerbations were lower at all treatment steps in BUD/FORM maintenance and reliever therapy versus same maintenance dose ICS/LABA (P Conclusions BUD/FORM maintenance and reliever therapy may be a preferable option for patients on Steps 2 to 4 of asthma guidelines requiring a more effective treatment and, compared with other fixed dose alternatives, is most effective in the higher treatment steps.

Bacterial inclusion bodies as potential synthetic devices for pathogen recognition and a therapeutic substance release.

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Talafová, Klaudia; Hrabárová, Eva; Chorvát, Dušan; Nahálka, Jozef

2013-02-07

Adhesins of pathogens recognise the glycans on the host cell and mediate adherence. They are also crucial for determining the tissue preferences of pathogens. Currently, glyco-nanomaterials provide potential tool for antimicrobial therapy. We demonstrate that properly glyco-tailored inclusion bodies can specifically bind pathogen adhesins and release therapeutic substances. In this paper, we describe the preparation of tailored inclusion bodies via the conjugation of indicator protein aggregated to form inclusion bodies with soluble proteins. Whereas the indicator protein represents a remedy, the soluble proteins play a role in pathogen recognition. For conjugation, glutaraldehyde was used as linker. The treatment of conjugates with polar lysine, which was used to inactivate the residual glutaraldehyde, inhibited unwanted hydrophobic interactions between inclusion bodies. The tailored inclusion bodies specifically interacted with the SabA adhesin from Helicobacter pylori aggregated to form inclusion bodies that were bound to the sialic acids decorating the surface of human erythrocytes. We also tested the release of indicator proteins from the inclusion bodies using sortase A and Ssp DNAB intein self-cleaving modules, respectively. Sortase A released proteins in a relatively short period of time, whereas the intein cleavage took several weeks. The tailored inclusion bodies are promising "nanopills" for biomedical applications. They are able to specifically target the pathogen, while a self-cleaving module releases a soluble remedy. Various self-cleaving modules can be enabled to achieve the diverse pace of remedy release.

Synthesis and characterization of poly (lactic acid)/chitosan nanocomposites based on renewable resources as biobased-material

Science.gov (United States)

Suryani; Agusnar, H.; Wirjosentono, B.; Rihayat, T.; Salisah, Z.

2018-01-01

Biobased becomes one of the new breakthrough in the smart engineering, especially in biomedical applications, such as tissue engineering that serves as a supporting physical structure to trigger the growth of skin tissue. From various studies which had been done, it was known that the optimal Biobased healed wounds or injuries in a relatively short time. In this study, a Biobased natural polymer based e.g Poly(Lactic Acid) (PLA)/Chitosan Nanocomposites was made. PLA was synthesized from saba banana (Musa acuminata) as raw material using Ring-Opening Polymerization (ROP) method. PLA was mixed with Chitosan with Chitosan concentration variations of 1%, 3%, and 5% to form a nanocomposites. The analysis result showed that Chitosan concentration in PLA/Chitosan Nanocomposites sample affected the value of tensile strength. The highest value of tensile strength was obtained on a sample of 100 ml volume with a concentration of 3%, which was 120.396 MPa. The highest percentage of elongation was obtained in 100 ml volume sample with 5% concentration, which was 26.3686%. In the hydrophilicity test, the highest percentage of water absorption was obtained in a 200 ml volume sample with 5% concentration, which was 44.615%. The addition of Chitosan to the sample affected the functional group bonding, where there was a functional group of NH2 at the wave number of 2923.92 cm-1. The sample characteristics based on water absorption indicated that the sample was potentially to be used as Biobased construction material.

Seismic evaluation of vulnerability for SAMA educational buildings in Tehran

International Nuclear Information System (INIS)

Amini, Omid Nassiri; Amiri, Javad Vaseghi

2008-01-01

Earthquake is a destructive phenomenon that trembles different parts of the earth yearly and causes many destructions. Iran is one of the (high seismicity) quack- prone parts of the world that has received a lot of pecuniary damages and life losses each year, schools are of the most important places to be protected during such crisis.There was no special surveillance on designing and building of school's building in Tehran till the late 70's, and as Tehran is on faults, instability of such buildings may cause irrecoverable pecuniary damages and especially life losses, therefore preventing this phenomenon is in an urgent need.For this purpose, some of the schools built during 67-78 mostly with Steel braced frame structures have been selected, first, by evaluating the selected Samples, gathering information and Visual Survey, the prepared questionnaires were filled out. With the use of ARIA and SABA (Venezuela) Methods, new modified combined method for qualified evaluations was found and used.Then, for quantified evaluation, with the use of computer 3D models and nonlinear statically analysis methods, a number of selected buildings of qualified evaluation, were reevaluated and finally with nonlinear dynamic analysis method the real behavior of structures on the earthquakes is studied.The results of qualified and quantified evaluations were compared and a proper Pattern for seismic evaluation of Educational buildings was presented. Otherwise the results can be a guidance for the person in charge of retrofitting or if necessary rebuilding the schools

Optimal treatment sequence in COPD: Can a consensus be found?

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J. Ferreira

2016-01-01

Full Text Available There is currently no consensus on the treatment sequence in chronic obstructive pulmonary disease (COPD, although it is recognized that early diagnosis is of paramount importance to start treatment in the early stages of the disease. Although it is fairly consensual that initial treatment should be with an inhaled short-acting beta agonist, a short-acting muscarinic antagonist, a long-acting beta-agonist or a long-acting muscarinic antagonist. As the disease progresses, several therapeutic options are available, and which to choose at each disease stage remains controversial. When and in which patients to use dual bronchodilation? When to use inhaled corticosteroids? And triple therapy? Are the existing non-inhaled therapies, such as mucolytic agents, antibiotics, phosphodiesterase-4 inhibitors, methylxanthines and immunostimulating agents, useful? If so, which patients would benefit? Should co-morbitities be taken into account when choosing COPD therapy for a patient?This paper reviews current guidelines and available evidence and proposes a therapeutic scheme for COPD patients. We also propose a treatment algorithm in the hope that it will help physicians to decide the best approach for their patients. The authors conclude that, at present, a full consensus on optimal treatment sequence in COPD cannot be found, mainly due to disease heterogeneity and lack of biomarkers to guide treatment. For the time being, and although some therapeutic approaches are consensual, treatment of COPD should be patient-oriented. Keywords: COPD, Treatment sequence, SABA, SAMA, LABA, LAMA, ICS, Triple therapy, Non-inhaled therapies

Formación de megacristales de feldespato potásico en el sector sur del batolito Cerro Aspero-Alpa Corral (32°40'S y 64°50'W, Sierras Pampeanas, Córdoba, Argentina

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Pinotti, L. P.

1992-12-01

Full Text Available The surrounding rocks of studied area are composed by a metamorphic sequence which includes gneisses, schists, amphibolites, marbles and heterogeneous migmatites in non-conformity intruded by a granitic pluton. All this sequence is dated as having late-Precambric to mid-Paleozoic age.Three facies, mostly of monzogranitic composition, were identified. This study focuses on the porphiric facies; detailed petroestructural studies being performed, the orientation of large microcline crystal and associated microgranular enclaves being measured.Different primary flow directions were determined with track variation of microcline megacrystal and enclaves from subvertical to nearly horizontal positions.These changes have been interpreted as a convective system within the pluton.The presence of a marked planar fabric in microcline megacrystals along with phenomena such a size-variation of crystal, synneusis, crystal trending at the enclave's border and crystal accumulation, proves their early magmatic origin. The enclaves show a cinematic of deformation produced by simple shear.El entorno encajante de la zona estudiada está integrado por una secuencia metamórfica que incluye gneises, esquistos, anfibolitas, calizas cristalinas y migmatitas heterogéneas, intruidas discordantemente por el plutón granítico. A este conjunto puede asignársele una edad precámbrica superior-paleozoica media.Se identificaron tres facies, en su mayoría de composición monzogranítica, diques micrograníticos a aplíticos y enclaves. En este trabajo se pone énfasis en la facies porfiroide efectuándose estudios petroestructurales de detalle, tomando como indicadores la orientación de los grandes cristales de microclina y enclaves microgranulares asociados.Se determinaron distintas direcciones de flujo primario con variaciones en la trayectoria de los megacristales de microclina y enclaves desde posiciones subverticales hasta aproximadamente horizontales. Estos cambios han sido interpretados como un sistema convectivo dentro del plutón.La presencia de una marcada fábrica planar en los megacristales de microclina, conjuntamente con fenómenos de gradaciones en el tamaño de cristales, sineusis, alineaciones en los bordes de enclaves y aglomeraciones de cristales evidencian su origen temprano magmático. Los enclaves muestran una cinemática de deformación producida por cizalla simple.

[Warning symptoms of asthma attack and asthma self-management: a national asthma control survey from China].

Science.gov (United States)

Lin, J T; Wang, W Q; Zhou, X; Wang, C Z; Huang, M; Cai, S X; Chen, P; Lin, Q C; Zhou, J Y; Gu, Y H; Yuan, Y D; Sun, D J; Yang, X H; Yang, L; Huo, J M; Chen, Z C; Jiang, P; Zhang, J; Ye, X W; Liu, H G; Tang, H P; Liu, R Y; Liu, C T; Zhang, W; Hu, C P; Chen, Y Q; Liu, X J; Dai, L M; Zhou, W; Huang, Y J; Xu, J Y

2017-08-08

Objective: To investigate warning symptoms of asthma attack and evaluate asthma self-management status of asthma patients in urban China. Methods: A multi-center, cross-sectional, questionnaire-based survey was carried out from 30 general hospitals dispersed in 30 provinces of mainland China (except for Tibet) during Oct 2015 to May 2016. Information of frequency and warning symptoms of asthma attack, the time from warning symptoms to asthma attack, the impact of asthma attack and asthma self-management were collected from asthma patients of outpatient department. Results: Altogether 3 875 asthmatic outpatients were recruited. 78.1% (3 026/3 875) of the patients reported restriction of exercise and daily activities during asthma exacerbation. 82.5% (3 160/3 829) of the patients had warning symptoms before asthma attack, the most common warning symptoms were cough, chest tightness and shortness of breath. The median time from warning symptoms to asthma attack was 2 h, the mean time was 90 h. Only 4.4% (167/3 829) of the patients had definite confidence to control asthma when symptoms deteriorated. 76.7% (2 937/3 828) of the patients used medications to control asthma when asthma symptoms deteriorated. Medication choice: inhaled corticosteroid (ICS) + formoterol 45.8% (1 776/3 875), short-acting beta-agonist (SABA) 23.9% (927/3 875). Conclusions: Most asthma patients have warning symptoms before asthma attack, the most common symptoms are cough, chest tightness and shortness of breath. The proportion of patients conducting effective asthma self-management remains low.

Medical students’ logbook case loads do not predict final exam scores in surgery clerkship

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Alabbad J

2018-04-01

Full Text Available Jasim Alabbad,1,2 Fawaz Abdul Raheem,2 Ahmad Almusaileem,1 Sulaiman Almusaileem,1 Saba Alsaddah,2 Abdulaziz Almubarak2 1Department of Surgery, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait; 2Department of Surgery, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait Purpose: To investigate the reliability of medical student logbook data in assessing student performance and predicting outcomes in an objective standardized clinical exam and a multiple-choice exam during surgery rotation. In addition, we examined the relationship between exam performance and the number of clinical tutors per student.Materials and methods: A retrospective review of the logbooks of first and third clinical year medical students at the Faculty of Medicine, Kuwait University, was undertaken during their surgery rotation during the academic year 2012–2013.Results: Logbooks of 184 students were reviewed and analyzed. There were 92 and 93 students in the first and third clinical years, respectively. We did not identify any correlation between the number of clinical encounters and clinical exam or multiple-choice exam scores; however, there was an inverse relationship between the number of clinical tutors encountered during a rotation and clinical exam scores.Conclusion: Overall, there was no correlation between the volume of self-reported clinical encounters and exam scores. Furthermore, an inverse correlation between the number of clinical tutors encountered and clinical exam scores was detected. These findings indicate a need for reevaluation of the way logbook data are entered and used as an assessment tool. Keywords: OSCE, assessment, Kuwait, universities, rotation

Ciberperiodismo en el estado Zulia: Hacia las nuevas competencias profesionales

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Carmen Mara Prieto

2009-05-01

Full Text Available El objetivo de la investigación se centró en describir el perfil profesional de los periodistas que laboran en los cibermedios del estado Zulia. Para abordar el problema se tomó como punto de partida las experiencias periodsticas vivenciadas en cibermedios zulianos (Faras y Prieto, 2006, 2007; Mogollón y Prieto, 2006 y el perfil del ciberperiodista definido por Albarrán (2008, Aguirre (2006, Saba (2006, Camus (2002 y Gil (1999. Esto implicó describir y caracterizar los equipos de profesionales que integran los cibermedios de la región zuliana en función de aportar a la configuración del perfil del nuevo periodista que pretenda desempeñarse con acierto en el ciberespacio. Desde el punto de vista metodológico, se trató de una investigación descriptiva de carácter cuantitativo con diseño transeccional donde se aplicó como instrumento la encuesta. Entre las conclusiones de la investigación destacan que las competencias ciberperiodsticas en su mayora están instrumentalizadas y asociadas al manejo de editores de texto y datos, as como Internet, siendo estas herramientas suficientes para cubrir las expectativas de sus labores, revelando en este sentido estar muy lejos de los constructos teórico-éticos que deben fundamentar el ciberperiodismo. Predomina en las ciberredacciones del estado Zulia profesionales jóvenes del género masculino egresados en el último lustro, y existe una falta de consenso en las denominaciones de cargos y funciones.

Effects of omalizumab in severe asthmatics across ages: A real life Italian experience.

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Sposato, B; Scalese, M; Latorre, M; Scichilone, N; Matucci, A; Milanese, M; Masieri, S; Rolla, G; Steinhilber, G; Rosati, Y; Vultaggio, A; Folletti, I; Baglioni, S; Bargagli, E; Di Tomassi, M; Pio, R; Pio, A; Maccari, U; Maggiorelli, C; Migliorini, M G; Vignale, L; Pulerà, N; Carpagnano, G E; Foschino Barbaro, M P; Perrella, A; Paggiaro, P L

2016-10-01

This retrospective study aimed at evaluating long-term effects of Omalizumab in elderly asthmatics in a real-life setting. 105 consecutive severe asthmatics (GINA step 4-5; mean FEV 1 % predicted:66 ± 15.7) treated with Omalizumab for at least 1 year (treatment mean duration 35.1 ± 21.7 months) were divided into 3 groups according to their age at Omalizumab treatment onset: 18-39, 40-64 and ≥ 65 years. Comorbidities, number of overweight/obese subjects and patients with late-onset asthma were more frequent among older people. A similar reduction of inhaled corticosteroids dosage and SABA on-demand therapy was observed in all groups during Omalizumab treatment; a similar FEV 1 increased was also observed. Asthma Control Test (ACT) improved significantly (p Omalizumab but the percentage of exacerbation-free patients was higher in younger people (76.9%) compared to middle aged patients (49.2%) and the elderly (29%) (p = 0.049). After Omalizumab treatment, the risk for exacerbations was lower in subjects aged 40-64 (OR = 0.284 [CI95% = 0.098-0.826], p = 0.021) and 18-39 (OR = 0.133 [CI95% = 0.026-0.678], p = 0.015), compared to elderly asthmatics. Also, a significantly reduced ACT improvement (β = -1.070; p = 0.046) passing from each age class was observed. Omalizumab improves all asthma outcomes independently of age, although the magnitude of the effects observed in the elderly seems to be lower than in the other age groups. Copyright © 2016 Elsevier Ltd. All rights reserved.

Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors

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Saba HI

2012-05-01

Full Text Available Hussain I Saba, Duc Quang Tran, JrDepartment of Medicine, University of South Florida Medical Center, Tampa, FL, USAAbstract: In the past, patients with severe hemophilia have suffered a substantially reduced quality of life with frequent bleeding episodes, disabling arthropathy, and shorter life expectancy. In addition, methods of treatment and management have been costly and time-consuming, and have placed a considerable burden on patients' physical and psychological well-being. With the advent of the on-demand therapy and prophylactic treatment paradigm, patients have been able to receive care with less interruption of daily activities. Treatments may be more challenging for hemophiliacs with inhibitors to replacement factor; however, recent advances in the use of bypassing agents and immune tolerance therapy have enabled them to aggressively manage their disease while maintaining their independence. This review focuses on the challenges of treating such a severe hemophiliac through examination of the lifetime experience of a young adult male with a severe form of congenital hemophilia A. At this stage of his life, the patient has minimal disabilities and is inhibitor-free through optimal care and strong family support. His aspiration to pursue a productive life has led him to a career in medicine. After receiving his medical degree, he pursued a specialty in the treatment of hemophilia. By assisting other hemophilia patients, he exemplifies both the rewards of persevering through episodes of bleeding and other complications and the fact that disabilities can be minimized when managed meticulously and in a timely fashion to enable a productive and dignified life.Keywords: hemophilia, quality of life, factor VIII inhibitors, hemophilia treatment center, early treatment, bypassing agent

Electron Microscopic, Genetic and Protein Expression Analyses of Helicobacter acinonychis Strains from a Bengal Tiger

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Tegtmeyer, Nicole; Rivas Traverso, Francisco; Rohde, Manfred; Oyarzabal, Omar A.; Lehn, Norbert; Schneider-Brachert, Wulf; Ferrero, Richard L.; Fox, James G.; Berg, Douglas E.; Backert, Steffen

2013-01-01

Colonization by Helicobacter species is commonly noted in many mammals. These infections often remain unrecognized, but can cause severe health complications or more subtle host immune perturbations. The aim of this study was to isolate and characterize putative novel Helicobacter spp. from Bengal tigers in Thailand. Morphological investigation (Gram-staining and electron microscopy) and genetic studies (16SrRNA, 23SrRNA, flagellin, urease and prophage gene analyses, RAPD DNA fingerprinting and restriction fragment polymorphisms) as well as Western blotting were used to characterize the isolated Helicobacters. Electron microscopy revealed spiral-shaped bacteria, which varied in length (2.5–6 µm) and contained up to four monopolar sheathed flagella. The 16SrRNA, 23SrRNA, sequencing and protein expression analyses identified novel H. acinonychis isolates closely related to H. pylori. These Asian isolates are genetically very similar to H. acinonychis strains of other big cats (cheetahs, lions, lion-tiger hybrid and other tigers) from North America and Europe, which is remarkable in the context of the great genetic diversity among worldwide H. pylori strains. We also found by immunoblotting that the Bengal tiger isolates express UreaseA/B, flagellin, BabA adhesin, neutrophil-activating protein NapA, HtrA protease, γ-glutamyl-transpeptidase GGT, Slt lytic transglycosylase and two DNA transfer relaxase orthologs that were known from H. pylori, but not the cag pathogenicity island, nor CagA, VacA, SabA, DupA or OipA proteins. These results give fresh insights into H. acinonychis genetics and the expression of potential pathogenicity-associated factors and their possible pathophysiological relevance in related gastric infections. PMID:23940723

Rhegmatogenous retinal detachments associated to Stickler syndrome in a tertiary eye care center in Saudi Arabia

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Alshahrani ST

2015-12-01

Full Text Available Saeed T Alshahrani,1 Nicola G Ghazi,2 Saba Al-Rashaed2 1Ophthalmology Department, King Fahad Specialist Hospital, Dammam, 2Vitreoretinal Department, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia Purpose: To investigate the clinical findings and outcomes of rhegmatogenous retinal detachment (RRD in Stickler syndrome on affected and fellow eyes that underwent prophylactic retinopexy.Patients and methods: Chart review of 70 eyes (62 patients. Incidence of RRD, postoperative visual acuity, and risk factors were evaluated.Results: Twenty-two patients (35% had RRD in the fellow eye, 37% of the eyes had cataract, 93% had macular detachment, 50% had proliferative vitreoretinopathy, and 41% had posterior vitreous detachment. Success rates were: 60% of patients after scleral buckling; 57.1% after pars plana vitrectomy; and 75% after combined scleral buckling and pars plana vitrectomy. Sixty-one (93.8% of patients had successful surgery (including second surgery. Silicone oil tamponade was significantly associated with final anatomic outcome, with a protective odds ratio of 0.11 (P=0.027. Visual acuity improved in 54% of eyes and decreased in 5%. Statistically significant associations were present for eyes with final visual acuity ≥20/200, and total retinal detachment (P<0.001; preoperative cataract (P=0.023; and proliferative vitreoretinopathy (P<0.001. RRD developed in 16/44 eyes despite laser prophylaxis.Conclusion: Prophylactic retinopexy was not beneficial for Stickler syndrome patients. Success of primary surgery for RRD remains low. The primary surgery should be vitrectomy combined with scleral buckling and silicone oil tamponade. Keywords: Stickler syndrome, retinopexy, Gulf States, Saudi Arabia, ocular genetics, arthro-ophthalmopathy, collagen disorder

Electron microscopic, genetic and protein expression analyses of Helicobacter acinonychis strains from a Bengal tiger.

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Nicole Tegtmeyer

Full Text Available Colonization by Helicobacter species is commonly noted in many mammals. These infections often remain unrecognized, but can cause severe health complications or more subtle host immune perturbations. The aim of this study was to isolate and characterize putative novel Helicobacter spp. from Bengal tigers in Thailand. Morphological investigation (Gram-staining and electron microscopy and genetic studies (16SrRNA, 23SrRNA, flagellin, urease and prophage gene analyses, RAPD DNA fingerprinting and restriction fragment polymorphisms as well as Western blotting were used to characterize the isolated Helicobacters. Electron microscopy revealed spiral-shaped bacteria, which varied in length (2.5-6 µm and contained up to four monopolar sheathed flagella. The 16SrRNA, 23SrRNA, sequencing and protein expression analyses identified novel H. acinonychis isolates closely related to H. pylori. These Asian isolates are genetically very similar to H. acinonychis strains of other big cats (cheetahs, lions, lion-tiger hybrid and other tigers from North America and Europe, which is remarkable in the context of the great genetic diversity among worldwide H. pylori strains. We also found by immunoblotting that the Bengal tiger isolates express UreaseA/B, flagellin, BabA adhesin, neutrophil-activating protein NapA, HtrA protease, γ-glutamyl-transpeptidase GGT, Slt lytic transglycosylase and two DNA transfer relaxase orthologs that were known from H. pylori, but not the cag pathogenicity island, nor CagA, VacA, SabA, DupA or OipA proteins. These results give fresh insights into H. acinonychis genetics and the expression of potential pathogenicity-associated factors and their possible pathophysiological relevance in related gastric infections.

Electron microscopic, genetic and protein expression analyses of Helicobacter acinonychis strains from a Bengal tiger.

Science.gov (United States)

Tegtmeyer, Nicole; Rivas Traverso, Francisco; Rohde, Manfred; Oyarzabal, Omar A; Lehn, Norbert; Schneider-Brachert, Wulf; Ferrero, Richard L; Fox, James G; Berg, Douglas E; Backert, Steffen

2013-01-01

Colonization by Helicobacter species is commonly noted in many mammals. These infections often remain unrecognized, but can cause severe health complications or more subtle host immune perturbations. The aim of this study was to isolate and characterize putative novel Helicobacter spp. from Bengal tigers in Thailand. Morphological investigation (Gram-staining and electron microscopy) and genetic studies (16SrRNA, 23SrRNA, flagellin, urease and prophage gene analyses, RAPD DNA fingerprinting and restriction fragment polymorphisms) as well as Western blotting were used to characterize the isolated Helicobacters. Electron microscopy revealed spiral-shaped bacteria, which varied in length (2.5-6 µm) and contained up to four monopolar sheathed flagella. The 16SrRNA, 23SrRNA, sequencing and protein expression analyses identified novel H. acinonychis isolates closely related to H. pylori. These Asian isolates are genetically very similar to H. acinonychis strains of other big cats (cheetahs, lions, lion-tiger hybrid and other tigers) from North America and Europe, which is remarkable in the context of the great genetic diversity among worldwide H. pylori strains. We also found by immunoblotting that the Bengal tiger isolates express UreaseA/B, flagellin, BabA adhesin, neutrophil-activating protein NapA, HtrA protease, γ-glutamyl-transpeptidase GGT, Slt lytic transglycosylase and two DNA transfer relaxase orthologs that were known from H. pylori, but not the cag pathogenicity island, nor CagA, VacA, SabA, DupA or OipA proteins. These results give fresh insights into H. acinonychis genetics and the expression of potential pathogenicity-associated factors and their possible pathophysiological relevance in related gastric infections.

Estimating the risk of dengue transmission from Dutch blood donors travelling to Suriname and the Dutch Caribbean.

Science.gov (United States)

Oei, W; Lieshout-Krikke, R W; Kretzschmar, M E; Zaaijer, H L; Coutinho, R A; Eersel, M; Jubithana, B; Halabi, Y; Gerstenbluth, I; Maduro, E; Tromp, M; Janssen, M P

2016-05-01

The risk of dengue transmitted by travellers is known. Methods to estimate the transmission by transfusion (TT) risk from blood donors travelling to risk areas are available, for instance, the European Up-Front Risk Assessment Tool (EUFRAT). This study aimed to validate the estimated risk from travelling donors obtained from EUFRAT. Surveillance data on notified dengue cases in Suriname and the Dutch Caribbean islands (Aruba, Curaçao, St. Maarten, Bonaire, St. Eustatius and Saba) in 2001-2011 was used to calculate local incidence rates. Information on travel and donation behaviour of Dutch donors was collected. With the EUFRAT model, the TT risks from Dutch travelling donors were calculated. Model estimates were compared with the number of infections in Dutch travellers found by laboratory tests in the Netherlands. The expected cumulative number of donors becoming infected during travels to Suriname and the Dutch Caribbean from 2001 to 2011 was estimated at 5 (95% CI, 2-11) and 86 (45-179), respectively. The infection risk inferred from the laboratory-based study was 19 (9-61) and 28 (14-92). Given the independence of the data sources, these estimates are remarkably close. The model estimated that 0·02 (0·001-0·06) and 0·40 (0·01-1·4) recipients would have been infected by these travelling donors. The EUFRAT model provided an estimate close to actual observed number of dengue infections. The dengue TT risk among Dutch travelling donors can be estimated using basic transmission, travel and donation information. The TT risk from Dutch donors travelling to Suriname and the Dutch Caribbean is small. © 2016 International Society of Blood Transfusion.

A retrospective analysis of practice patterns in the management of acute asthma attack across Turkey.

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Türktaş, Haluk; Bavbek, Sevim; Misirligil, Zeynep; Gemicioğlu, Bilun; Mungan, Dilşad

2010-12-01

To evaluate patient characteristics and practice patterns in the management of acute asthma attack at tertiary care centers across Turkey. A total of 294 patients (mean age: 50.4 ± 15.1 years; females: 80.3%) diagnosed with persistent asthma were included in this retrospective study upon their admission to the hospital with an acute asthma attack. Patient demographics, asthma control level, asthma attack severity and the management of the attack were evaluated. There was no influence of gender on asthma control and attack severity. In 57.5% of the patients, asthma attack was moderate. Most patients (78.9%) were hospitalized with longer duration evident in the severe attack. Spirometry and chest X-Ray were the most frequent tests (85.4%), while steroids (72.0% parenteral; 29.0% oral) and short-acting beta-agonists (SABA) + anticholinergics (45.5%) were the main drugs of choice in the attack management. Attack severity and pre-attack asthma control level was significantly correlated (p attack asthma was uncontrolled in 42.6% of the patients with severe attack. Most of the patients were on combination of more than one (two in 38.7% and 3-4 in 31.2%) controller drugs before the attack. Providing country specific data on practice patterns in the management of acute asthma attack in a representative cohort in Turkey, prescription of steroids and SABA + anticholinergics as the main drugs of choice was in line with guidelines while the significant relation of pre-attack asthma control to risk/severity of asthma attack and rate/duration of hospitalization seem to be the leading results of the present study. Copyright © 2010 Elsevier Ltd. All rights reserved.

Comparison of Three Orthoses Effects on Planter Fascitis

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Ma'soumeh Nakha'ei

2008-12-01

Full Text Available Objective: Plantar Fasciitis is the common foot complaint that outbreaks as a result of an inflammation of plantar fascia. The purpose of this study was to compare the effectiveness of three orthoses, silicon heel pad, thermoplastic custom-made arch support and Tension Night splint, how they relived pain in plantar fasciitis. Materials & Methods: In this quasi experimental study that was done on 16 patients who were referred from Shariati Hospital Orthopedic ward to Saba Orthotics & Prosthetics Center age, sex, BMI, occupation and activity level were not inclusion criteria, systemic diseases and also surgery on foot in past were as exclusion criteria. The patients were assigned one by one to three treatment groups who were ready to admit them. Subject's pain was assessed for 3 months, at 2nd, 6th and 12th week, by Numerical Rating Scale and Verbal Rating Scale through phone. Data were analyzed with ANOVA, Pierson’s and Spearman’s correlation coefficients, Kruskal-Wallis test and Repeated Measurement test. Results: The coefficient correlation of Numerical score pain and rating score pain were 0.80. The average of morning (P=0.87, evening (P=0.198 and the worse pain (P=0.113 before entering the study were similar in three groups. The repeated measurement test defined that all the three orthoses were effective for the morning, evening and as so for the worse pain (P<0.001. There was not significant difference among the three groups in decrease of morning (P=0.483, evening (P=0.462 and worse pain (P=0.948.  Conclusion: Taking advantage of the three orthoses without any treatment was effective for the Plantar Fasciitis pain in this study.

Interaction of colloidal nanoparticles with cells (Conference Presentation)

Science.gov (United States)

Parak, Wolfgang J.

2017-02-01

What happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver, superparamagnetic iron oxide, or fluorescent quantum dot NPs, after they have been administrated to an animal or a human being? The review discusses the integrity, biodistribution, and fate of NPs after in vivo administration. First the hybrid nature of the NPs is described, by conceptually dividing them into the inorganic NP core, an engineered surface coating around the core which comprises the ligand shell and optionally also bioconjugation, and into the corona of adsorbed biological molecules. It is shown that in vivo all of these three compounds may degrade individually and that each of them can drastically modify the life-cycle and biodistribution of the whole hetero-structure. The NPs thus may be disintegrated into different parts, of which biodistribution and fate would need to be analyzed individually. Multiple labelling and quantification strategies for such purpose will be discussed. All reviewed data indicate that in vivo NPs no longer should be considered as homogeneous entity, but should be seen as inorganic/organic/biological nano-hybrids with complex and intricately linked degradation pathways. References: M. Chanana, P. Rivera Gil, M. A. Correa-Duarte, L. M. Liz-Marzán. W. J. Parak, "Physicochemical Properties of Protein-Coated Gold Nanoparticles in Biological Fluids and Cells before and after Proteolytic Digestion", Angewandte Chemie International Edition 52, 4179-4183 (2013). W. G. Kreyling, A. M. Abdelmonem, Z. Ali, F. Alves, M. Geiser, N. Haberl, R. Hartmann, S. Hirn, K. Kantner, D. Jimenez de Aberasturi, G. Khadem-Saba, J.-M. Montenegro, J. Rejman, T. Rojo, I. Ruiz de Larramendi, R. Ufartes, A. Wenk, W. J. Parak, "In vivo integrity of polymer-coated gold nanoparticles", Nature Nanotechnology 10, 619-623 (2015).J. Clerk Maxwell, A Treatise on Electricity and Magnetism, 3rd ed., vol. 2. Oxford: Clarendon, 1892, pp.68-73.

Human gastric mucins differently regulate Helicobacter pylori proliferation, gene expression and interactions with host cells.

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Emma C Skoog

Full Text Available Helicobacter pylori colonizes the mucus niche of the gastric mucosa and is a risk factor for gastritis, ulcers and cancer. The main components of the mucus layer are heavily glycosylated mucins, to which H. pylori can adhere. Mucin glycosylation differs between individuals and changes during disease. Here we have examined the H. pylori response to purified mucins from a range of tumor and normal human gastric tissue samples. Our results demonstrate that mucins from different individuals differ in how they modulate both proliferation and gene expression of H. pylori. The mucin effect on proliferation varied significantly between samples, and ranged from stimulatory to inhibitory, depending on the type of mucins and the ability of the mucins to bind to H. pylori. Tumor-derived mucins and mucins from the surface mucosa had potential to stimulate proliferation, while gland-derived mucins tended to inhibit proliferation and mucins from healthy uninfected individuals showed little effect. Artificial glycoconjugates containing H. pylori ligands also modulated H. pylori proliferation, albeit to a lesser degree than human mucins. Expression of genes important for the pathogenicity of H. pylori (babA, sabA, cagA, flaA and ureA appeared co-regulated in response to mucins. The addition of mucins to co-cultures of H. pylori and gastric epithelial cells protected the viability of the cells and modulated the cytokine production in a manner that differed between individuals, was partially dependent of adhesion of H. pylori to the gastric cells, but also revealed that other mucin factors in addition to adhesion are important for H. pylori-induced host signaling. The combined data reveal host-specific effects on proliferation, gene expression and virulence of H. pylori due to the gastric mucin environment, demonstrating a dynamic interplay between the bacterium and its host.

Transscleral Selective Laser Trabeculoplasty Without a Gonioscopy Lens.

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Geffen, Noa; Ofir, Shay; Belkin, Avner; Segev, Fani; Barkana, Yaniv; Kaplan Messas, Audrey; Assia, Ehud I; Belkin, Michael

2017-03-01

The purpose of the study was to investigate results of selective laser trabeculoplasty (SLT) performed directly on the sclera without a gonioscopy lens. Interventional case series, prospective, randomized, masked, controlled clinical trial. Setting: Meir Medical Center, Kfar-Saba, Israel. Adults with uncontrolled primary open angle or pseudoexfoliation glaucoma randomized into 2 groups. The controls underwent conventional SLT with 100 spots delivered using a gonioscopy lens for 360 degrees of the trabecular meshwork. The study group underwent irradiation using the same parameters with the laser applications administered on the perilimbal sclera. Study visits: 1 hour, 1, 7, 30, 60, 180, and 365 days postprocedure. Intraocular pressure (IOP) and side effects. Thirty adults were randomized into 2 groups. The mean (±SD) pretreatment IOP was 20.21±3.19 mm Hg for the study group (n=14) and 21.14±2.98 mm Hg for the controls (n=14; P =0.43), dropping to 15.50±3.77 and 15.00±4.08 mm Hg (P =0.74) after 6 months and to 16.00±3.31 and 14.00±2.45 mm Hg (P =0.22) after 12 months. The average IOP reduction after 6 and 12 months was 23.4% and 20.83% for the study group and 27.1% and 33.77% for the controls (P=0.528). Success (a decrease of ≥15% at 6 months with no additional medications, laser, or glaucoma surgery) was achieved in 12 (85.7%) study patients and 9 (69.2%) controls (P=0.385). Complications were mild and transient (n=30), although significantly higher in the controls (n=15; P <0.0001). SLT applied directly to the perilimbal sclera may be as efficacious as the conventional procedure for 1 year.

Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy

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Karlsson J

2015-07-01

Full Text Available Johan Karlsson, Saba Atefyekta, Martin Andersson Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden Abstract: The osseointegration capacity of bone-anchoring implants can be improved by the use of drugs that are administrated by an inbuilt drug delivery system. However, to attain superior control of drug delivery and to have the ability to administer drugs of varying size, including proteins, further material development of drug carriers is needed. Mesoporous materials have shown great potential in drug delivery applications to provide and maintain a drug concentration within the therapeutic window for the desired period of time. Moreover, drug delivery from coatings consisting of mesoporous titania has shown to be promising to improve healing of bone-anchoring implants. Here we report on how the delivery of an osteoporosis drug, alendronate, can be controlled by altering pore size and surface energy of mesoporous titania thin films. The pore size was varied from 3.4 nm to 7.2 nm by the use of different structure-directing templates and addition of a swelling agent. The surface energy was also altered by grafting dimethylsilane to the pore walls. The drug uptake and release profiles were monitored in situ using quartz crystal microbalance with dissipation (QCM-D and it was shown that both pore size and surface energy had a profound effect on both the adsorption and release kinetics of alendronate. The QCM-D data provided evidence that the drug delivery from mesoporous titania films is controlled by a binding–diffusion mechanism. The yielded knowledge of release kinetics is crucial in order to improve the in vivo tissue response associated to therapeutic treatments. Keywords: mesoporous titania, controlled drug delivery, release kinetics, alendronate, QCM-D

S-wave velocities of the lithosphere-asthenosphere system in the Lesser Antilles from the joint inversion of surface wave dispersion and receiver function analysis

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González, O'Leary; Clouard, Valerie; Tait, Stephen; Panza, Giuliano F.

2018-06-01

We present an overview of S-wave velocities (Vs) within the crust and upper mantle of the Lesser Antilles as determined with 19 seismic broadband stations. Receiver functions (RF) have been computed from teleseismic recordings of earthquakes, and Rayleigh wave group velocity dispersion relations have been taken from earlier surface wave tomographic studies in the Caribbean area. Local smoothness optimization (LSO) procedure has been applied, combined with an H-K stacking method, the spatial distribution of hypocenters of local earthquakes and of the energy they released, in order to identify an optimum 1D model of Vs below each station. Several features of the Caribbean plate and its interaction with the Atlantic subducting slab are visible in the resulting models: (a) relatively thick oceanic crust below these stations ranges from 21 km to 33 km, being slight thinner in the middle of the island arc; (b) crustal low velocity zones are present below stations SABA, SEUS, SKI, SMRT, CBE, DSD, GCMP and TDBA; (c) lithospheric thickness range from 40 km to 105 km but lithosphere-asthenosphere boundary was not straightforward to correlate between stations; (d) the aseismic mantle wedge between the Caribbean seismic lithosphere and the subducted slab varies in thickness as well as Vs values which are, in general, lower below the West of Martinique than below the West of Guadeloupe; (e) the depth of the subducted slab beneath the volcanic arc, appears to be greater to the North, and relatively shallower below some stations (e.g. DLPL, SAM, BIM and FDF) than was estimated in previous studies based on the depth-distribution of seismicity; f) the WBZ is >10-15 km deeper than the top of the slab below the Central Lesser Antilles (Martinique and Dominica) where the presence of partial melt in the mantle wedge seems also to be more evident.

The Many Riches of Human Flourishing: On the Veiled Agent in Veil Narratives

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Muneer Aram Kuzhiyan

2014-05-01

Full Text Available This paper critiques what it calls the parochial conception of agency animating the narrative of the Malayalam writer Khadija Mumthas' novel Barsa (2007 that is anchored in the notion that acts of resistance to relations of domination exhaust the field of human action. Following contemporary cultural anthropologists Talal Asad (1993, Saba Mahmood (2005 and Charles Hirschkind (2006, I argue that if unveiling of a Muslim woman in the spirit of liberatory endeavour constitutes one modality of action, the religiously-inspired programme of moral formation, including adopting the veil, practiced by many Muslim women in Kerala, as elsewhere, often decried for their patriarchal proclivities is also a speech act that makes up agency, no less. I find particularly useful here the idea of 'docility' that Mahmood (2005 develops out of Foucault (1990: rather than being a synonym for passivity, 'docility' in this line of thought takes on a meaning of 'teachability' that demands will, effort and perseverance. This understanding brings to sharp relief the Foucauldian insight that specific relations of subordination enable and enact modes of human agency. Lost in Khadija Mumthas' monologue of agency is the fact that divergent conceptual understandings of a practice create divergent subjectivities and social and political life worlds and it would be a mistake to privilege one over the other. The novel, I argue, betrays the author's dis-ease with the modalities of agency other than subverting norms and belies the burden of proving Islam's compatibility with the ideals of liberalism-a burden she shares with many contemporary Muslim reformers who fit the bill 'liberal Islam.' Finally, by way of comparison and contrast, I call attention to the anglophone Sudanese writer Leila Aboulela's two novels The Translator (1999 and Minaret (2005 which, even as they exploit as one of their key thematic concerns the role of religion in the protagonists' identity formation and

Minimally invasive treatment of lumbar spinal stenosis with a novel interspinous spacer

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Shabat S

2011-09-01

Full Text Available Shay Shabat1, Larry E Miller2,3, Jon E Block3, Reuven Gepstein11Spinal Care Unit, Sapir Medical Center, Kfar Saba, Israel; 2Miller Scientific Consulting, Inc, Biltmore Lake, NC, USA; 3Jon E Block, PhD, Inc, San Francisco, CA, USAPurpose: To assess the safety and effectiveness of a novel, minimally invasive interspinous spacer in patients with moderate lumbar spinal stenosis (LSS.Methods: A total of 53 patients (mean age, 70 ± 11 years; 45% female with intermittent neurogenic claudication secondary to moderate LSS, confirmed on imaging studies, were treated with the Superion® Interspinous Spacer (VertiFlex, Inc, San Clemente, CA and returned for follow-up visits at 6 weeks, 1 year, and 2 years. Study endpoints included axial and extremity pain severity with an 11-point numeric scale, Zurich Claudication Questionnaire (ZCQ, back function with the Oswestry Disability Index (ODI, health-related quality of life with the Physical Component Summary (PCS and Mental Component Summary (MCS scores from the SF-12, and adverse events.Results: Axial and extremity pain each decreased 54% (both P < 0.001 over the 2-year follow-up period. ZCQ symptom severity scores improved 43% (P < 0.001 and ZCQ physical function improved 44% (P < 0.001 from pre-treatment to 2 years post-treatment. A statistically significant 50% improvement (P < 0.001 also was noted in back function. PCS and MCS each improved 40% (both P < 0.001 from pre-treatment to 2 years. Clinical success rates at 2 years were 83%–89% for ZCQ subscores, 75% for ODI, 78% for PCS, and 80% for MCS. No device infection, implant breakage, migration, or pull-out was observed, although two (3.8% patients underwent explant with subsequent laminectomy.Conclusion: Moderate LSS can be effectively treated with a minimally invasive interspinous spacer. This device is appropriate for select patients who have failed nonoperative treatment measures for LSS and meet strict anatomical criteria.Keywords: Superion, axial

Abscisic acid analogs as chemical probes for dissection of abscisic acid responses in Arabidopsis thaliana.

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Benson, Chantel L; Kepka, Michal; Wunschel, Christian; Rajagopalan, Nandhakishore; Nelson, Ken M; Christmann, Alexander; Abrams, Suzanne R; Grill, Erwin; Loewen, Michele C

2015-05-01

Abscisic acid (ABA) is a phytohormone known to mediate numerous plant developmental processes and responses to environmental stress. In Arabidopsis thaliana, ABA acts, through a genetically redundant family of ABA receptors entitled Regulatory Component of ABA Receptor (RCAR)/Pyrabactin Resistant 1 (PYR1)/Pyrabactin Resistant-Like (PYL) receptors comprised of thirteen homologues acting in concert with a seven-member set of phosphatases. The individual contributions of A. thaliana RCARs and their binding partners with respect to specific physiological functions are as yet poorly understood. Towards developing efficacious plant growth regulators selective for specific ABA functions and tools for elucidating ABA perception, a panel of ABA analogs altered specifically on positions around the ABA ring was assembled. These analogs have been used to probe thirteen RCARs and four type 2C protein phosphatases (PP2Cs) and were also screened against representative physiological assays in the model plant Arabidopsis. The 1'-O methyl ether of (S)-ABA was identified as selective in that, at physiologically relevant levels, it regulates stomatal aperture and improves drought tolerance, but does not inhibit germination or root growth. Analogs with the 7'- and 8'-methyl groups of the ABA ring replaced with bulkier groups generally retained the activity and stereoselectivity of (S)- and (R)-ABA, while alteration of the 9'-methyl group afforded an analog that substituted for ABA in inhibiting germination but neither root growth nor stomatal closure. Further in vitro testing indicated differences in binding of analogs to individual RCARs, as well as differences in the enzyme activity resulting from specific PP2Cs bound to RCAR-analog complexes. Ultimately, these findings highlight the potential of a broader chemical genetics approach for dissection of the complex network mediating ABA-perception, signaling and functionality within a given species and modifications in the future design

Woodlands House Nursing Home, Trim Road, Navan, Meath.

LENUS (Irish Health Repository)

O'Toole, Paul W

2010-03-10

Abstract Background Helicobacter mustelae causes gastritis, ulcers and gastric cancer in ferrets and other mustelids. H. mustelae remains the only helicobacter other than H. pylori that causes gastric ulceration and cancer in its natural host. To improve understanding of H. mustelae pathogenesis, and the ulcerogenic and carcinogenic potential of helicobacters in general, we sequenced the H. mustelae genome, and identified 425 expressed proteins in the envelope and cytosolic proteome. Results The H. mustelae genome lacks orthologs of major H. pylori virulence factors including CagA, VacA, BabA, SabA and OipA. However, it encodes ten autotransporter surface proteins, seven of which were detected in the expressed proteome, and which, except for the Hsr protein, are of unknown function. There are 26 putative outer membrane proteins in H. mustelae, some of which are most similar to the Hof proteins of H. pylori. Although homologs of putative virulence determinants of H. pylori (NapA, plasminogen adhesin, collagenase) and Campylobacter jejuni (CiaB, Peb4a) are present in the H. mustelae genome, it also includes a distinct complement of virulence-related genes including a haemagglutinin\\/haemolysin protein, and a glycosyl transferase for producing blood group A\\/B on its lipopolysaccharide. The most highly expressed 264 proteins in the cytosolic proteome included many corresponding proteins from H. pylori, but the rank profile in H. mustelae was distinctive. Of 27 genes shown to be essential for H. pylori colonization of the gerbil, all but three had orthologs in H. mustelae, identifying a shared set of core proteins for gastric persistence. Conclusions The determination of the genome sequence and expressed proteome of the ulcerogenic species H mustelae provides a comparative model for H. pylori to investigate bacterial gastric carcinogenesis in mammals, and to suggest ways whereby cag minus H. pylori strains might cause ulceration and cancer. The genome sequence was

Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen

LENUS (Irish Health Repository)

O'Toole, Paul W

2010-03-10

Abstract Background Helicobacter mustelae causes gastritis, ulcers and gastric cancer in ferrets and other mustelids. H. mustelae remains the only helicobacter other than H. pylori that causes gastric ulceration and cancer in its natural host. To improve understanding of H. mustelae pathogenesis, and the ulcerogenic and carcinogenic potential of helicobacters in general, we sequenced the H. mustelae genome, and identified 425 expressed proteins in the envelope and cytosolic proteome. Results The H. mustelae genome lacks orthologs of major H. pylori virulence factors including CagA, VacA, BabA, SabA and OipA. However, it encodes ten autotransporter surface proteins, seven of which were detected in the expressed proteome, and which, except for the Hsr protein, are of unknown function. There are 26 putative outer membrane proteins in H. mustelae, some of which are most similar to the Hof proteins of H. pylori. Although homologs of putative virulence determinants of H. pylori (NapA, plasminogen adhesin, collagenase) and Campylobacter jejuni (CiaB, Peb4a) are present in the H. mustelae genome, it also includes a distinct complement of virulence-related genes including a haemagglutinin\\/haemolysin protein, and a glycosyl transferase for producing blood group A\\/B on its lipopolysaccharide. The most highly expressed 264 proteins in the cytosolic proteome included many corresponding proteins from H. pylori, but the rank profile in H. mustelae was distinctive. Of 27 genes shown to be essential for H. pylori colonization of the gerbil, all but three had orthologs in H. mustelae, identifying a shared set of core proteins for gastric persistence. Conclusions The determination of the genome sequence and expressed proteome of the ulcerogenic species H mustelae provides a comparative model for H. pylori to investigate bacterial gastric carcinogenesis in mammals, and to suggest ways whereby cag minus H. pylori strains might cause ulceration and cancer. The genome sequence was

Survey of intravitreal injection techniques among retina specialists in Israel

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Segal O

2016-06-01

Full Text Available Ori Segal,1,2 Yael Segal-Trivitz,1,3 Arie Y Nemet,1,2 Noa Geffen,1,2 Ronit Nesher,1,2 Michael Mimouni4 1Department of Ophthalmology, Meir Medical Center, Kfar Saba, 2The Sackler School of Medicine, Tel Aviv University, Tel Aviv, 3Department of Psychiatry, Geha Psychiatric Hospital, Petah Tikva, 4Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel Purpose: The purpose of this study was to describe antivascular endothelial growth factor intravitreal injection techniques of retinal specialists in order to establish a cornerstone for future practice guidelines. Methods: All members of the Israeli Retina Society were contacted by email to complete an anonymous, 19-question, Internet-based survey regarding their intravitreal injection techniques. Results: Overall, 66% (52/79 completed the survey. Most (98% do not instruct patients to discontinue anticoagulant therapy and 92% prescribe treatment for patients in the waiting room. Three quarters wear sterile gloves and prepare the patient in the supine position. A majority (71% use sterile surgical draping. All respondents apply topical analgesics and a majority (69% measure the distance from the limbus to the injection site. A minority (21% displace the conjunctiva prior to injection. A majority of the survey participants use a 30-gauge needle and the most common quadrant for injection is superotemporal (33%. Less than half routinely assess postinjection optic nerve perfusion (44%. A majority (92% apply prophylactic antibiotics immediately after the injection. Conclusion: The majority of retina specialists perform intravitreal injections similarly. However, a relatively large minority performs this procedure differently. Due to the extremely low percentage of complications, it seems as though such differences do not increase the risk. However, more evidence-based medicine, a cornerstone for practice guidelines, is required in order to identify the intravitreal injection techniques

BAKUNIN'S SON, A DIALOGIC NOVEL BY SERGIO ATZENI

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Masina Depperu (Universidade de Lisboa

2013-10-01

Full Text Available Bakunin’s Son, a short novel by Sergio Atzeni, is the perfect embodiment of Bakhtin’s theory of the dialogic novel. The author sets his stories and characters - mostly humble outcast defeated people - in his own homeland, Sardinia. The accurately planned structure as an interview to thirty-two people reflects a multifarious reality with its complex rules and mentality expressed through different points of view, languages and ideologies. The protagonist’s story may result contradictory according to the different opinions of people who met him. Also the choice of a hybrid language contributes to create a highly connoted cultural context. In Bakunin’s Son, in fact, the Italian and the Sardinian overlap in a manner that cannot be distinguished or graphically marked, since form and meaning are fused together.Key words: dialogic novel, hybrid language.O filho de Bakunin, um romance polifónico de Sergio AtzeniO romance breve de Sergio Atzeni, O filho de Bakunin, è a perfeita exemplificação da teoria bachtininana do romance polifónico. O autor insere as histórias e as persona gens, geralmente abatidas, pessoas humildes e marginalizadas, na sua terra natal, a Sardenha. A história è estruturada na forma de entrevista a trinta e duas persona gens que com os seus pontos de vista criam una realidade multi-facetada e subjectiva. A vida de Tullio Saba, o protagonista, está narrada às vezes em modo contraditório e, por isso, os factos podem ser divergentes nas opiniões de quem esteve mais ou menos em contacto directo com ele. O uso característico de um instrumento linguístico híbrido, a meio caminho entre o italiano e o sardo, conota não somente o léxico mas também a estruturação inteira do discurso que atinge o efeito final pretendido pelo autor de descrever uma diversa ealidade antropológico-cultural.Palavras chave: romance polifónico, instrumento linguístico híbrido

Presentación del Libro “Diabetes en Colombia. Recuento Historico y Bibliográfico”

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Alfredo Jácome Roca

2005-03-01

Por estos tiempos también era común que los clínicos probaran la orina de los pacientes para ver si estaba “dulce” y así poder hacer el diagnóstico al pie de la cama del enfermo. No se trataba por supuesto de tomarse el líquido como si se tratara de una limonada; era más bien poner un dedo y pasarlo por la lengua, lo que sonaría algo menos desagradable. García Márquez describe esta costumbre en su novela “El amor en los tiempos del cólera” cuando cuenta que (el doctor Juvenal Urbino, hijo de médico y de clase social alta en Cartagena, había estudiado en París a la usanza de la época, al lado de los grandes profesores. A su regreso trató de imponer criterios novedosos en el Hospital de la Misericordia, pero no le fue tan fácil… pues la rancia casa de salud se empecinaba en sus costumbres atávicas… no podían soportar que el joven recién llegado saboreara la orina del enfermo para descubrir la presencia de azúcar o que citara a Charcot y a Trousseau como si fueran sus compañeros de cuarto…” Cuenta Ucrós Cuéllar que José María Lombana Barreneche, instruyendo a sus alumnos sobre este hábito, le pidió a uno de ellos que pusiera un dedo en el chorro de la orina del enfermo y la probara; cuando el estudiante siguió al pie de la letra las instrucciones de Lombana, este lo llamó aparte y le dijo: Usted pone un dedo, pero se chupa el otro. Un don Sabas –personaje de Gabo en “El coronel no tiene quien le escriba”, no nuestro ministro del interior– es un enfermo diabético...

Evaluation of the geometric stability and the accuracy potential of digital cameras — Comparing mechanical stabilisation versus parameterisation

Science.gov (United States)

Rieke-Zapp, D.; Tecklenburg, W.; Peipe, J.; Hastedt, H.; Haig, Claudia

Recent tests on the geometric stability of several digital cameras that were not designed for photogrammetric applications have shown that the accomplished accuracies in object space are either limited or that the accuracy potential is not exploited to the fullest extent. A total of 72 calibrations were calculated with four different software products for eleven digital camera models with different hardware setups, some with mechanical fixation of one or more parts. The calibration procedure was chosen in accord to a German guideline for evaluation of optical 3D measuring systems [VDI/VDE, VDI/VDE 2634 Part 1, 2002. Optical 3D Measuring Systems-Imaging Systems with Point-by-point Probing. Beuth Verlag, Berlin]. All images were taken with ringflashes which was considered a standard method for close-range photogrammetry. In cases where the flash was mounted to the lens, the force exerted on the lens tube and the camera mount greatly reduced the accomplished accuracy. Mounting the ringflash to the camera instead resulted in a large improvement of accuracy in object space. For standard calibration best accuracies in object space were accomplished with a Canon EOS 5D and a 35 mm Canon lens where the focusing tube was fixed with epoxy (47 μm maximum absolute length measurement error in object space). The fixation of the Canon lens was fairly easy and inexpensive resulting in a sevenfold increase in accuracy compared with the same lens type without modification. A similar accuracy was accomplished with a Nikon D3 when mounting the ringflash to the camera instead of the lens (52 μm maximum absolute length measurement error in object space). Parameterisation of geometric instabilities by introduction of an image variant interior orientation in the calibration process improved results for most cameras. In this case, a modified Alpa 12 WA yielded the best results (29 μm maximum absolute length measurement error in object space). Extending the parameter model with Fi

Integrating Volcanic Hazard Data in a Systematic Approach to Develop Volcanic Hazard Maps in the Lesser Antilles

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Jan M. Lindsay

2018-04-01

Full Text Available We report on the process of generating the first suite of integrated volcanic hazard zonation maps for the islands of Dominica, Grenada (including Kick ‘em Jenny and Ronde/Caille, Nevis, Saba, St. Eustatius, St. Kitts, Saint Lucia, and St Vincent in the Lesser Antilles. We developed a systematic approach that accommodated the range in prior knowledge of the volcanoes in the region. A first-order hazard assessment for each island was used to develop one or more scenario(s of likely future activity, for which scenario-based hazard maps were generated. For the most-likely scenario on each island we also produced a poster-sized integrated volcanic hazard zonation map, which combined the individual hazardous phenomena depicted in the scenario-based hazard maps into integrated hazard zones. We document the philosophy behind the generation of this suite of maps, and the method by which hazard information was combined to create integrated hazard zonation maps, and illustrate our approach through a case study of St. Vincent. We also outline some of the challenges we faced using this approach, and the lessons we have learned by observing how stakeholders have interacted with the maps over the past ~10 years. Based on our experience, we recommend that future map makers involve stakeholders in the entire map generation process, especially when making design choices such as type of base map, use of colour and gradational boundaries, and indeed what to depict on the map. We also recommend careful consideration of how to evaluate and depict offshore hazard of island volcanoes, and recommend computer-assisted modelling of all phenomena to generate more realistic hazard footprints. Finally, although our systematic approach to integrating individual hazard data into zones generally worked well, we suggest that a better approach might be to treat the integration of hazards on a case-by-case basis to ensure the final product meets map users' needs. We hope that

Glycyrrhetinic acid and E.resveratroloside act as potential plant derived compounds against dopamine receptor D3 for Parkinson’s disease: a pharmacoinformatics study

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Mirza MU

2014-12-01

Full Text Available Muhammad Usman Mirza,1 A Hammad Mirza,2 Noor-Ul-Huda Ghori,3 Saba Ferdous4 1Centre for Research in Molecular Medicine, The University of Lahore, Lahore, Pakistan; 2Department of Bioscience, COMSATS Institute of Information Technology, Sahiwal, Pakistan; 3Atta-ur-Rehman School of Applied Biosciences, National University of Science and Technology, Islamabad, Pakistan; 4Institute of Structural and Molecular Biology, University College London, UK Abstract: Parkinson’s disease (PD is caused by loss in nigrostriatal dopaminergic neurons and is ranked as the second most common neurodegenerative disorder. Dopamine receptor D3 is considered as a potential target in drug development against PD because of its lesser side effects and higher degree of neuro-protection. One of the prominent therapies currently available for PD is the use of dopamine agonists which mimic the natural action of dopamine in the brain and stimulate dopamine receptors directly. Unfortunately, use of these pharmacological therapies such as bromocriptine, apomorphine, and ropinirole provides only temporary relief of the disease symptoms and is frequently linked with insomnia, anxiety, depression, and agitation. Thus, there is a need for an alternative treatment that not only hinders neurodegeneration, but also has few or no side effects. Since the past decade, much attention has been given to exploitation of phytochemicals and their use in alternative medicine research. This is because plants are a cheap, indispensable, and never ending resource of active compounds that are beneficial against various diseases. In the current study, 40 active phytochemicals against PD were selected through literature survey. These ligands were docked with dopamine receptor D3 using AutoDock and AutoDockVina. Binding energies were compared to docking results of drugs approved by the US Food and Drug Administration against PD. The compounds were further analyzed for their absorption, distribution

Caracterización física, morfológica y evaluación de las curvas de empastamiento de musáceas (Musa spp.

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Javier Darío Hoyos-Leyva

2012-07-01

Full Text Available Se caracterizaron veinte variedades de musáceas de diferente composición genética: AB, BB, AAA, AAB, ABB, AAAA y AAAB, del Banco de Germoplasma existente en la hacienda Las Vegas, de Fedeplátano, Chinchiná (1360 m.s.n.m., 4° 58' N y 75° 20' O, Colombia. La caracterización incluyó propiedades físicas como peso, diámetro, longitud, materia seca y porcentaje de cáscara del fruto y propiedades funcionales como harinas y almidones. El análisis de componentes principales (ACP mostró que las variedades de plátano se diferencian por su mayor tamaño (peso, longitud y diámetro. M. B. Tani, ICAFHIA 110, Saba, y los plátanos del subgrupo Bluggoe tuvieron altos porcentajes de cáscara. Entre los demás clones no se observaron diferencian entre sí. Los plátanos de cocción del subgrupo Plantain presentaron el mayor contenido de materia seca. Bocadillo Chileno e híbridos postre (exceptuando FHIA-1, presentaron mayor contenido de fracción comestible frente a las demás variedades. La temperatura de inicio de gelatinización de las harinas en el RVA varió entre 66.58 °C para la variedad Bocadillo Chileno y 75.21 °C para Mbindi. La viscosidad máxima varió entre 441.57 y 1837.17 cP para las variedades Tafetán Rojo y Dwarf Cavendish, respectivamente. La facilidad de cocción varió entre 2.76 min en Bocadillo Chileno y 7.55 min en Gros Michel Guayabo. La temperatura de inicio de gelatinización de los almidones varió entre 65.58°C para Gros Michel Guayabo y 74.41°C en Tafetán Rojo. La variedad Yangambi Km3 presentó la viscosidad máxima a 483.24 cP e Indio a 1958.44cP. La variedad Mbindi presentó la mayor facilidad de cocción (1.91 min mientras que FHIA-1 presentó el mayor tiempo (9.49 min.

Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress

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Saba Naqvi

2010-11-01

Full Text Available Saba Naqvi1, Mohammad Samim2, MZ Abdin3, Farhan Jalees Ahmed4, AN Maitra5, CK Prashant6, Amit K Dinda61Faculty of Engineering and Interdisciplinary Sciences, 2Department of Chemistry, 3Department of Biotechnology, Faculty of Science, 4Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, 5Department of Chemistry, University of Delhi, 6Department of Pathology, All India Institute of Medical Sciences, New Delhi, IndiaAbstract: Iron oxide nanoparticles with unique magnetic properties have a high potential for use in several biomedical, bioengineering and in vivo applications, including tissue repair, magnetic resonance imaging, immunoassay, drug delivery, detoxification of biologic fluids, cell sorting, and hyperthermia. Although various surface modifications are being done for making these nonbiodegradable nanoparticles more biocompatible, their toxic potential is still a major concern. The current in vitro study of the interaction of superparamagnetic iron oxide nanoparticles of mean diameter 30 nm coated with Tween 80 and murine macrophage (J774 cells was undertaken to evaluate the dose- and time-dependent toxic potential, as well as investigate the role of oxidative stress in the toxicity. A 15–30 nm size range of spherical nanoparticles were characterized by transmission electron microscopy and zeta sizer. MTT assay showed >95% viability of cells in lower concentrations (25–200 µg/mL and up to three hours of exposure, whereas at higher concentrations (300–500 µg/mL and prolonged (six hours exposure viability reduced to 55%–65%. Necrosis-apoptosis assay by propidium iodide and Hoechst-33342 staining revealed loss of the majority of the cells by apoptosis. H2DCFDDA assay to quantify generation of intracellular reactive oxygen species (ROS indicated that exposure to a higher concentration of nanoparticles resulted in enhanced ROS generation, leading to cell injury and death. The cell membrane injury

Ether lipid vesicle-based antigens impart protection against experimental listeriosis

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Ansari MA

2012-06-01

Full Text Available Mairaj Ahmed Ansari,1 Swaleha Zubair,2 Saba Tufail,1 Ejaj Ahmad,1 Mohsin Raza Khan,1 Zainuddin Quadri,1 Mohammad Owais,11Interdisciplinary Biotechnology Unit, 2Women's College, Aligarh Muslim University, Aligarh, UP, IndiaBackground: Incidence of food-borne infections from Listeria monocytogenes, a parasite that has adapted intracellular residence to avoid antibody onslaught, has increased dramatically in the past few years. The apparent lack of an effective vaccine that is capable of evoking the desired cytotoxic T cell response to obliterate this intracellular pathogen has encouraged the investigation of alternate prophylactic strategies. It should also be noted that Archaebacteria (Archae lipid-based adjuvants enhance the efficacy of subunit vaccines. In the present study, the adjuvant properties of archaeosomes (liposomes prepared from total polar lipids of archaebacteria, Halobacterium salinarum combined with immunogenic culture supernatant antigens of L. monocytogenes have been exploited in designing a vaccine candidate against experimental listeriosis in murine model.Methods: Archaeosome-entrapped secretory protein antigens (SAgs of L. monocytogenes were evaluated for their immunological responses and tendency to deplete bacterial burden in BALB/c mice challenged with sublethal listerial infection. Various immunological studies involving cytokine profiling, lymphocyte proliferation assay, detection of various surface markers (by flowcytometric analysis, and antibody isotypes (by enzyme-linked immunosorbent assay were used for establishing the vaccine potential of archaeosome-entrapped secretory proteins.Results: Immunization schedule involving archaeosome-encapsulated SAgs resulted in upregulation of Th1 cytokine production along with boosted memory in BALB/c mice. It also showed protective effect by reducing listerial burden in various vital organs (liver and spleen of the infected mice. However, the soluble form of the antigens (SAgs

Nanotetrac targets integrin αvβ3 on tumor cells to disorder cell defense pathways and block angiogenesis

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Davis PJ

2014-09-01

Full Text Available Paul J Davis,1,2 Hung-Yun Lin,2,3 Thangirala Sudha,2 Murat Yalcin,2,4 Heng-Yuan Tang,2 Aleck Hercbergs,5 John T Leith,6 Mary K Luidens,1 Osnat Ashur-Fabian,7,8 Sandra Incerpi,9 Shaker A Mousa2 1Department of Medicine, Albany Medical College, Albany, NY, USA; 2Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, USA; 3PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; 4Department of Physiology, Veterinary Medicine Faculty, Uludag University, Gorukle, Bursa, Turkey; 5Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA; 6Rhode Island Nuclear Science Center, Narragansett, RI, USA; 7Translational Hemato-oncology Laboratory, Hematology Institute and Blood Bank, Meir Medical Center, Kfar-Saba, Israel; 8Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 9Department of Sciences, University of Roma Tre, Rome, Italy Abstract: The extracellular domain of integrin αvβ3 contains a receptor for thyroid hormone and hormone analogs. The integrin is amply expressed by tumor cells and dividing blood vessel cells. The proangiogenic properties of thyroid hormone and the capacity of the hormone to promote cancer cell proliferation are functions regulated nongenomically by the hormone receptor on αvβ3. An L-thyroxine (T4 analog, tetraiodothyroacetic acid (tetrac, blocks binding of T4 and 3,5,3'-triiodo-L-thyronine (T3 by αvβ3 and inhibits angiogenic activity of thyroid hormone. Covalently bound to a 200 nm nanoparticle that limits its activity to the cell exterior, tetrac reformulated as Nanotetrac has additional effects mediated by αvβ3 beyond the inhibition of binding of T4 and T3 to the integrin. These actions of Nanotetrac include disruption of transcription of cell survival pathway genes, promotion of apoptosis by multiple mechanisms, and interruption

Surveying the effect of a self-care education program on severity of nausea and emesis in colorectal cancer patients under chemotherapy

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Karimi S

2017-08-01

Full Text Available Saba Karimi,1 Behnam Reza Makhsosi,2 Seyed Jalil Seyedi-Andi,3 Maryam Behzadi,4 Yasaman Moghofeh,5 Kourosh Mohammadinasrabadi,1 Alireza Abdi,1 Pegah Ahmadi1 1School of Nursing and Midwifery, 2Surgical Department, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, 3Social Determinants of Health Research Center, Babol University of Medical Sciences, Babol, 4Taleghani Hospital, 5Imam Khomeini Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Background and objective: Colorectal cancer is one of the main causes of mortality in both developed and developing countries, including Iran. One of the treatments available for colorectal cancer is chemotherapy, of which nausea and emesis are the side effects. Owing to problems in controlling the side effects, a combination of medicine and non-medicine interventions is usually used. Self-care is one of the non-medicine interventions in this regard. The present study was aimed at surveying the effect of a self-care education program on severity of nausea and emesis in colorectal cancer patients under chemotherapy.Methods: A semi-experimental study was carried out in Imam Reza Hospital of Kermanshah, Iran. The sample group comprised 52 patients with colorectal cancer under chemotherapy. Data gathering tools included a demographics questionnaire and Morrow Assessment of Nausea and Emesis. To control intensity of nausea and emesis, a package of self-care measures including muscular progressive relaxation, music, and education on nutrition was used. Afterward, the collected data were analyzed using statistical tests such as Shapiro–Wilk test (to check normal distribution of the data, Mann–Whitney U test, Wilcoxon test, and chi-square test with the help of SPSS 20.Results: The results showed a considerable decrease in intensity and frequency of nausea and emesis after the intervention. The p-value of Mann–Whitney U test results with regard to intensity of nausea in

Simvastatin modulates gingival cytokine and MMP production in a rat model of ligature-induced periodontitis

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Mouchrek Júnior JCE

2017-05-01

Full Text Available José Carlos Elias Mouchrek Júnior,1 Cristina Gomes Macedo,2 Henrique Ballassini Abdalla,2 Ana Karina Saba,1 Lucas Novaes Teixeira,1 Adriana Quinzeiro e Silva Mouchrek,3 Marcelo Henrique Napimoga,1 Juliana Trindade Clemente-Napimoga,1 Alvaro Henrique Borges,4 Mateus Rodrigues Tonetto,4 Shelon Cristina Souza Pinto,5 Matheus Coelho Bandeca,3 Elizabeth Ferreira Martinez1 1Laboratory of Cell and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, 2Physiological Sciences, Piracicaba Dental School, University of Campinas, Campinas, São Paulo, 3Department of Dentistry, CEUMA University, São Luis, Maranhão, 4Department of Integrated Dental Science, University of Cuiaba, Cuiabá, Mato Grosso, 5Department of Dentistry, Ponta Grossa State University, Ponta Grossa, Paraná, Brazil Purpose: The aim of this study was to evaluate the effect of simvastatin on the synthesis of cytokines TNF-α and IL-10 and metalloproteinase (MMPs 2 and 9 in a rat model of ligature-induced periodontitis.Materials and methods: Twenty Wistar rats were used, and a cotton ligature was place in a subgingival position encircling the entire cervix of the first molar of the left (ipsilateral side of the mandible. The right (contralateral side of the mandible had no ligature placed and was used as control. After the ligature placement, animals were randomly assigned to two experimental groups (n=10: 1 rats with ligature + vehicle (saline; 10 mL/kg; orally and 2 rats with ligature + simvastatin (25 mg/kg; orally. After 14 days of treatment, the animals were euthanized by anesthetic overdose and the gingival tissue was removed and homogenized in appropriate buffer. MMP-2 and -9 release as well as the IL-10 and TNF-α levels were detected by enzyme-linked immunosorbent assay. Statistical comparison was performed by unpaired Student’s t-test, with p<0.05 representing significance.Results: No differences were observed for TNF-α production between the

Survey of discomfort glare from the headlamps of cars widely used in Iran.

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Mehri, Ahmad; Farhang Dehghan, Somayeh; Hajizadeh, Roohalah; Zakerian, Seyed Abolfazl; Mohammadi, Hamzeh; Abbasi, Milad

2017-10-03

On 2-lane roads, discomfort glare can cause annoyance, discomfort, inconvenience, stress, and fatigue to drivers, posing a risk of accidents. The aim of this study is to evaluate discomfort glare from the headlamps of cars widely used in Iran. The discomfort glare of new vehicles including Pride Saba model GTX, Pride Model 131SL, Samand Soren, Peugeot 405, Megane, and Peugeot Pars was examined at distances of 5 to 100 m at a background luminance of 50 cd/m 2 (late twilight/early dawn lighting) and 1 cd/m 2 (nighttime) using Schmidt-Clausen and Bindels model and de Boer's subjective scale. According to the de Boer scale, at a background luminance of 50 cd/m 2 , the discomfort glare for all studied vehicles was between 1.98 and 4.05 in high-beam mode and between 3.5 and 5.4 in low-beam mode. At a background luminance of 1 cd/m 2 , discomfort glare was between 0.41 and 2.48 in high-beam mode and between 1.93 and 3.84 in low-beam mode. In high-beam mode, the average levels of discomfort glare of these vehicles gradually increased when the distance between cars was reduced by up to about 20 m. In low-beam mode, there was no discomfort glare up to a vehicle distance of 40 m. In addition, at an angle of 1.15°-5.73° between the line of sight and light of vehicles in high-beam mode, the level of discomfort glare was increased, but at an angle of 5.73°-22.9° the level of discomfort glare was reduced. In low-beam mode at an angle of 2.86°-22.9°, the level of discomfort glare was almost identical. The results show that in high-beam mode and with a 100-m distance between vehicles as well as in low-beam mode at intervals of less than 40 m between cars, discomfort glare is created. It can be concluded that by providing solutions such as installing road lighting system, an increase in luminance of roads, separating or widening road lanes, increasing the lateral distance between vehicles, and increasing the angle between lighted vehicles and drivers can noticeably

Structure, Content, Delivery, Service, and Outcomes: Quality e-Learning in higher education

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Colla J. MacDonald

2005-07-01

Full Text Available This paper addresses the need for quality e-Learning experiences. We used the Demand-Driven Learning Model (MacDonald, Stodel, Farres, Breithaupt, and Gabriel, 2001 to evaluate an online Masters in Education course. Multiple data collection methods were used to understand the experiences of stakeholders in this case study: the learners, design team, and facilitators. We found that all five dimensions of the model (structure, content, delivery, service, and outcomes must work in concert to implement a quality e-Learning course. Key themes include evolving learner needs, the search for connection, becoming an able e-participant, valued interactions, social construction of content, integration of delivery partners, and mindful weighing of benefits and trade-offs. By sharing insights into what is needed to design and deliver an e-Learning experience, our findings add to the growing knowledge of online learning. Using this model to evaluate perceptions of quality by key stakeholders has led to insights and recommendations on the Demand Driven Learning Model itself which may be useful for researchers in this area and strengthen the model. Quality has been defined in terms of the design of the e-Learning experience, the contextualized experience of learners, and evidence of learning outcomes (Carr and Carr, 2000; Jung 2000; Salmon, 2000. Quality and design of e-Learning courses, however, are sometimes compromised in an “ . . . effort to simply get something up and running��� in response to pressing consumer demands (Dick, 1996, p. 59. Educators and researchers have voiced concern over the lack of rigorous evaluation studies of e-Learning programs (e.g., Arbaugh, 2000; Howell, Saba, Lindsay, and Williams, 2004; Lockyer, Patterson, and Harper, 1999; Robinson, 2001. McGorry (2003 adds, “although the number of courses being delivered via the Internet is increasing rapidly, our knowledge of what makes these courses effective learning experiences

Lipoproteína (a está associada com níveis basais de insulina em pacientes com Diabetes Mellitus tipo 2 Lipoproteína (a está asociada a niveles basales de insulina en pacientes con Diabetes Mellitus tipo 2 Lipoprotein (a is associated with basal insulin levels in patients with type 2 Diabetes Mellitus

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Syed Shahid Habib

2009-07-01

Full Text Available FUNDAMENTO: Ainda não foi claramente estabelecido se a resistência/deficiência insulínica leva diretamente à aterogênese ou através de sua associação com outros fatores de risco como os níveis de lipoproteína (a[Lp(a]. OBJETIVO: O objetivo do estudo foi estabelecer a relação entre os níveis basais de insulina, lípides e lipoproteína (a em pacientes com diabetes mellitus (DM tipo 2. MÉTODOS: Amostras de sangue foram colhidas em jejum e os níveis de insulina, lipoproteína (a, colesterol total (CT, triglicérides (TG, lipoproteína de baixa densidade (LDL-C, lipoproteína de alta densidade (LDL-C, glicose e hemoglobina glicada (HbA1c foram medidos em 60 pacientes com DM tipo 2 e 28 indivíduos saudáveis. Nós dividimos os pacientes em dois grupos baseados nos níveis basais de insulina: > 10 µIU/ml e 10 µIU/ml comparados com aqueles que apresentavam insulina basal FUNDAMENTO: Todavía no se aclaró totalmente si la resistencia/deficiencia insulínica lleva directamente a la aterogénesis o a través de su asociación con otros factores de riesgo como los niveles de lipoproteína (a [Lp(a]. OBJETIVO: : El objetivo del estudio fue establecer la relación entre los niveles basales de insulina, lípidos y lipoproteína (a en pacientes con diabetes mellitus (DM tipo 2. MÉTODOS: Se extrajeron muestras de sangre en ayuno y se determinaron los niveles de insulina, lipoproteína (a, colesterol total (CT, triglicéridos (TG, lipoproteína de baja densidad (LDL-C, lipoproteína de alta densidad (LDL-C, glucosa y hemoglobina glicosilada (HbA1c en 60 pacientes con DM tipo 2 y 28 individuos sanos. Dividimos a los pacientes en dos grupos basados en los niveles basales de insulina: > 10 µIU/ml y 10 µIU/ml comparados con aquellos que presentaban insulina basal BACKGROUND: It has not been clearly established whether insulin resistance/deficiency leads directly to atherogenesis or through its association with other risk factors such as

Selected Abstracts of the 12th International Workshop on Neonatology; Cagliari (Italy; October 19-22, 2016

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--- Various Authors

2016-10-01

Full Text Available Selected Abstracts of the 12th International Workshop on Neonatology; Cagliari (Italy; October 19-22, 2016ABS 1. ABNORMAL FETAL GROWTH ALTERS THE METABOLIC PROFILE OF EARLY HUMAN MILK • A. Kontogeorgou, Ch. Fotakis, D.D. Briana, T. Boutsikou, A. Malamitsi-Puchner, P. ZoumpoulakisABS 2. VENTED BASE FEEDING BOTTLE IN PRETERM INFANTS WITH GERD SYMPTOMS: EFFECTS ON RESPIRATION-DEGLUTITION PATTERNS AND REFLUX • E. Cocchi, C. Zavattero, E. Maggiora, C. Peila, A. Coscia, E. Bertino, F. CresiABS 3. ANALYSIS OF CIRCULATING miRNAs IN OBESE CHILDREN BORN SMALL FOR GESTATIONAL AGE • M.F. Faienza, F. Marzano, G. D'Amato, E. Inzaghi, A. Annese, M.F. Caratozzolo, A.M. D'Erchia, M. Chiara, D. Horner, E. Sbisà, L. Cavallo, G. Pesole, S. Cianfarani, A. Del Vecchio, A. TulloABS 4. CELOSOMY: OMPHALOCELE AND GASTROSCHISIS • F. Ayari, H. Chourou, H. Mannai, M. Chour, I. Ksibi, N. Ben Ameur, M. Ben Ammara, S. KacemABS 5. BREAST MILK IN INTRAUTERINE GROWTH RESTRICTION: DIFFERENCES COMPARED TO ADEQUATE FOR GESTATIONAL AGE INFANTS • C. Fadda, A. Reali, R. Pintus, F. Deidda, A. DessìABS 6. A RATHER UNIQUE AND UNEXPECTED PEDIATRIC SURGICAL CASE • G. Gaido, E.M. Nyaga, P.E. RolandiABS 7. VATER SYNDROME • M. Tuveri, C. Porcu, G. Ottonello, L. SabaABS 8. SEVERE NECROTIZING ENTEROCOLITIS ASSOCIATED WITH GASTROSCHISIS: DIFFICULTIES OF CARE • F. Ayari, W. Barbaria, E. Marmech, I. Ksibi, M. Cheour, N. Ben Ameur, M. Ben Ammara, S. KacemABS 9. RECURRENT ABDOMINAL PAIN AND JUVENILE SOLITARY POLYP (JSP: A CASE REPORT • L. Nai Fovino, V. Rametta, F. Rigon, G. Passarella, F. Rimondi, C. Santagati, M. Berardi, F. Marino, S. Innaurato, E. Michelin, C. Lorenzetto, S. Rossin, S. RugolottoABS 10. ULTRASOUND MONITORING OF LIVER ABSCESSES IN NEWBORNS • S. de Nardi, C. Porcu, M. Puddu, M.C. Pintus, M.A. Marcialis, L. SabaABS 11. RESPIRATORY PROBLEMS IN CHILDREN WITH REPAIRED ESOPHAGEAL ATRESIA AND TRACHEOESOPHAGEAL FISTULA • F. Porcaro, L. Valfrè, L. Rotondi

Mineralogy, chemistry of magnetite and genesis of Korkora-1 iron deposit, east of Takab, NW Iran

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Mohammad Maanijou

2014-10-01

Full Text Available Introduction There is an iron mining complex called Shahrak 60 km east of Takab town, NW Iran. The exploration in the Shahrak deposit (general name for all iron deposits of the area started in 1992 by Foolad Saba Noor Co. and continued in several periods until 2008. The Shahrak deposit comprising 10 ore deposits including Korkora-1, Korkora-2, Shahrak-1, Shahrak-2, Shahrak-3, Cheshmeh, Golezar, Sarab-1, Sarab-2, and Sarab-3 deposits Sheikhi, 1995 with total 60 million tons of proved ore reserves. The Fe grade ranges from 45 to 65% (average 50%. The ore reserves of these deposits vary and the largest one is Korkora-1 with 15 million tons of 55% Fe and 0.64% S. The Korkora-1 ore deposit is located in western Azarbaijan and Urumieh-Dokhtar volcanic zone, at the latitude of 36°21.8´, and longitude of 47°32´. Materials and methods Six thin-polished sections were made on magnetite, garnet, and amphibole for EPMA (Electron Probe Micro Analysis. EPMA was performed using a JEOL JXA-733 electron microprobe at the University of New Brunswick, Canada, with wavelength-dispersive spectrometers. Results and discussion Outcropped units of the area are calc-alkaline volcanics of rhyolite, andesite and dacite and carbonate rocks of Qom Formation in which intrusion of diorite to granodiorite and quartzdoirite caused contact metamorphism, alteration plus skarnization and formation of actinolite, talc, chlorite, phlogopite, quartz, calcite, epidote and marblization in the vicinity of the ore deposit. Iron mineralization formed at the contacts of andesite and dacite with carbonates in Oligo-Miocene. The study area consists of skarn, metamorphic rocks, and iron ore zones. The shape of the deposit is lentoid to horizontal with some alteration halos. The ore occurred as replacement, massive, disseminated, open-space filling and breccia. The ore minerals of the deposit include low Ti-magnetite (0.04 to 0.2 wt % Ti, minor apatite, and sulfide minerals such as pyrite

Sistema de classificação de pacientes em assistência domiciliária Sistema de classificación de pacientes en atención domiciliaria Patients classification system in home care

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Luiza Watanabe Dal Ben

2006-03-01

Full Text Available OBJETIVOS: O objetivo deste artigo é apresentar os Sistemas de Classificação de Pacientes (SCP existentes nessa área. MÉTODOS: revisão bibliográfica. RESULTADOS: Os instrumentos encontrados foram: de Garrard et al, Home Health Care Classification System4.4 Método Home Health Care Classification System (HHCC, segundo Saba (1991, Escala Katz, as tabelas utilizadas pela Associação Brasileira de Empresas de Medicina de Internação Domiciliar e pelo Núcleo Nacional das Empresas de Assistência Domiciliar, o TISS-Intermediário adaptado por Dal Ben e o catálogo de prestação de serviços da "Fondation des Services d'aide et de Soins à Domicile". Desses instrumentos os dois últimos mensuram a carga de trabalho e os demais apresentam indicadores para obter recursos humanos e financeiros. CONSIDERAÇÕES FINAIS: Quanto ao tempo despendido na assistência ao paciente considera-se como dependência total 24 horas; dependência parcial 12 horas; dependência moderada 6 horas de assistência / dia / paciente.OBJETIVO: el objetivo de este articulo es presentar los sistemas de clasificación de pacientes existentes en esta area. METODOS: revisión bibliográfica. RESULTADOS: Los instrumentos encuentrados fueron: de Garrard et al, Home Health Care Classification System, Escala Katz, las tablas utilizadas por la Asociación Brasileña de Empresas de Medicina de Atencion Domiciliaria y por el Nucleo Nacional de Empresas de Atención Domiciliaria, el TISS-Intermediário adaptado por Dal Ben y el catálogo de la prestación de servicios de la "Fundación de servicios de ayuda y atención domiciliária". De eses instrumentos los dos ultimos miden la carga del trabajo y los demás presentan indicadores para obtener los recursos humanos y financieros. CONSIDERACIONES FINALES: Cuanto al tiempo gasto en la atención del paciente se considera de 24 horas para los que tienen dependencia total, de 12 horas para los que tienen dependencia parcial y de 6

Vahdet-i Vücûd Düşüncesini Açıklamada Halı Sembolizmi ve Muhyiddin-i Rûmî’nin Temsîl-i Kālîçe İsimli Risâlesi / The Symbolism of the Rug (Qalicha to Expound the Doctrine of the Unity of Being and Muhyiddin al-Rumi's treatise "Tamthil Qalicha"

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Hür Mahmut Yücer

2017-06-01

Full Text Available Abstract In the Islamic thought, Wahdat Wujud (The Unity of Being is generally defined as a doctrine which discusses the transition of the real being (the absolute being to the methaphorical (the relative one, its formation and quality. By means of this doctrine, questions concerning the relations of Allah, the universe and human being are answered and many obscure issues found in the Holy Qur'an and the hadiths become intelligible. In the center of the doctrine of the Unity of Being occur the categories of being such as maratib al-wujud (the ranks of being, hadarat khamsa (the five presences and tanazzulat sab'a (the seven condescensions. The categories of being have been long dealt with in a similar manner in almost every corner of the Islamic World through explanatory works like those in the form of sharh (commentary. In order to facilitate the comprehension of the subject in question a number of symbolisms such as seed and tree, point and letter, steam and ice, mirror and dream (shadow have been utilised. The symbolism of the rug (qalicha which is focused by the present study has not been studied or drawn attention to until today. Thus Muhyi's treatise, Tamthil Qalicha is quite compelling. This study firstly endeavors to elucidate the symbolism of the rug and then presents a Turkish transliteration of the said treatise of Muhyi, Tamthil Qalicha. Öz Vahdet-i vücûd, İslam düşüncesinde en genel anlamıyla hakîki varlıktan mecâziye geçişi, kılınış (ca’liyet ve nasıllığı anlatan nazariyenin adıdır. Bu nazariye ile Allah-âlem-insan münasebeti hakkında sorular karşılıklarını bulurve Kur’ân-ı Kerîm ve hadislerde geçen birçok müteşabih konu anlaşılır hale gelir. Vahdet-i vücud nazariyesinin ana çatısını merâtibü’l-vücûd, hazerât-ı hams, tenezzülât-ı seb’a gibi farklı isimlerle ifade edilen varlık kategorileri oluşturur. Varlık mertebeleri tarih boyunca İslam dünyasının her b

Stability and subsidence across Rome (Italy) in 2011-2013 based on COSMO-SkyMed Persistent Scatterer Interferometry

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Francesca, Cigna; Lasaponara, Rosa; Nicola, Masini; Pietro, Milillo; Deodato, Tapete

2015-04-01

constraints that can prevent, even at such high spatial resolution, obtaining satisfactory PS densities in peri-urban areas with high vegetation coverage. With regard to recent deformation patterns, COSMO-SkyMed time series confirm the persistence of subsidence processes in southern Rome. In areas of recent urbanization, such as that surrounding the Basilica of St Paul Outside-the-Walls, the estimated vertical motion velocity reaches values higher than -7.0 mm/yr. Further proof of the potentiality of COSMO-SkyMed constellation to extend almost seamlessly ground motion time series from previous SAR missions is offered by the deformation detected at the single-monument scale over the archaeological ruins of the Oppian Hill, the monuments and historical building in the riverside quarter of Trastevere, and the Basilica di San Saba within the Aurelian Walls. References [1] Tapete, D.; Fanti, R.; Cecchi, R.; Petrangeli, P.; Casagli, N. Satellite radar interferometry for monitoring and early-stage warning of structural instability in archaeological sites. J. Geophys. Eng. 2012, 9 S10-S25. [2] Tapete, D.; Casagli, N.; Fanti, R. Radar interferometry for early stage warning on monuments at risk. In Landslide Science and Practice; Margottini, C., Canuti, P., Sassa, K., Eds.; Springer: Berlin/Heidelberg, Germany, 2013; Volume 1, pp. 619-625. [3] Stramondo, S.; Bozzano, F.; Marra, F.; Wegmuller, U.; Cinti, F.R.; Moro, M.; Saroli, M. Subsidence induced by urbanisation in the city of Rome detected by advanced InSAR technique and geotechnical investigations. Remote Sens. Environ. 2008, 112, 3160-3172. [4] Cigna, F.; Lasaponara, R.; Masini, N.; Milillo, P.; Tapete, D. Persistent Scatterer Interferometry Processing of COSMO-SkyMed StripMap HIMAGE Time Series to Depict Deformation of the Historic Centre of Rome, Italy. Remote Sens. 2014, 6, 12593-12618.

Hydrometallurgical processing of nickel lateritic ores / Гидрометаллургическая обработка латеритных руд никеля / Hidrometalurško tretiranje lateritnih ruda nikla

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Srećko R. Stopić

2016-10-01

�акие как: лес, реки и пр. Очень важно понимать и оценить применение латеритных руд в области горной промышленности и металлургии в разных частях мира. В данной статье представлено несколько эксплуатационных сценариев латеритных руд в области гидрометаллургии: Direct Nickel Process, Murrin Murrin и Ravensthorpe в Австралии, и META Process в Турции. / Proizvodnja nikla je vrlo značajna aktivnost u zemljama Evropske unije, jer nikal je važan dodatak u nerđajućim čelicima. Evropa ima resurse oksidnih ruda duž dobro poznatog prostora koji započinje od Alpa i završava se na Himalajima. Ovaj opasač prolazi kroz zapadni Balkan i Grčku i nastavlja se kroz Tursku do Azije. Poznati depoziti lateritnih ruda u Srbiji smešteni su u tri zone: Zapadnoj Moravi (Ruđinci, Veluce, Ba, Šumadiji (Lipovac, Kolarevići, Bučje i Mokroj gori, koje predstavljaju prirodne resurse, kao što su šume i reke. Lateritna ruda tretira se u rudarstvu i metalurgiji u raznim područjima sveta. U ovom radu biće predstavljeno nekoliko eksploatacionih scenarija preko hidrometalurškog tretiranja: „Direct Nickel Process”, „Murrin Murrin” i „Ravensthorpe” u Australiji, i „META Process” u Turskoj.

Selected Abstracts of the 13th International Workshop on Neonatology; Cagliari (Italy; October 25th-28th, 2017

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--- Various Authors

2017-10-01

. GençABS 78. EATING DISORDERS IN TEENAGERS: A CASE REPORT OF ANOREXIA NERVOSA • A. CiubaraABS 79. ECHOCARDIOGRAPHIC DIFFERENCES BE­TWEEN SGA AND AGA FETUSES • S. Visentin, A. Zanella, M. Andolfatto, E. CosmiABS 80. ENDOSCOPIC TREATMENTS IN PEDIATRIC DIGESTIVE PATHOLOGY • M. BurleaABS 81. WHICH DOPPLER PARAMETER DURING THE SECOND TRIMESTER ULTRASOUND SHOULD BE ASSESSED AS PREDICTOR FOR SMALL FOR GESTATIONAL AGE FETUS? • S. Visentin, A. Zanella, M. Andolfatto, E. CosmiABS 82. CAPICE: CHILDHOOD AND ADOLESCENCE PSYCHOPATHOLOGY: UNRAVELING THE COM­PLEX ETIOLOGY BY A LARGE INTER­DISCI­PLINARY COLLABORATION IN EUROPE • H. Rajula, C.M. Middeldorp, W. Drevets, M.R. Jarvelin, P. Lichtenstein, S. Lundström, M. Munafò, R. Plomin, H. Tiemeier, S.M. van den Berg, A. Noto, V. Fanos, M. Bartels; EAGLE ConsortiumABS 83. URINARY METABOLOMICS IN TERM NEW­BORNS DELIVERED SPONTANEOUSLY OR WITH CESAREAN SECTION: PRELIMINARY DATA • F.-P. Martin, S. Rezzi, M. Lussu, R. Pintus, M.C. Pattumelli, A. Noto, A. Dessi, L. Da Silva, S. Collino, R. Agostino, L. Orfeo, L. Atzori, V. FanosABS 84. ANALYSIS OF TRACE METAL CONCEN­TRA­TIONS IN HUMAN’S MILK. A PILOT STUDY • F. Congiu, S. Furcas, M. D’Alterio, F. Dessolis, M. Orlando, M. Anardu, D. Deiana, A. Angioni, S. AngioniABS 85. METABOLOMIC ANALYSIS OF PLACENTA TISSUE IN OBESE PREGNANCIES • C. Fattuoni, C. Mandò, F. Palmas, G.M. Anelli, C. Novielli, E. Parejo Laudicina, V.M. Savasi, L. Barberini, A. Dessì, R. Pintus, V. Fanos, A. Noto, I. CetinABS 86. PATAU SYNDROME: RADIOLOGICAL CHAR­AC­TER­ISTICS • S. De Nardi, C. Porcu, G. Ledda, L. SabaABS 87. A CASE REPORT OF BECKWITH-WIEDEMANN SYNDROME: THE LENS OF THE RADIOLOGIST • F. Allegra, G. Ledda, C. Porcu, L. SabaABS 88. THE TYPE OF DELIVERY STRONGLY IMPACTS ON THE COLOSTRUM MICROBIOTA COM­POSITION • S. D’Elios, M. Toscano, P. Comberiati, L. Drago, E. Grossi, D.G. PeroniABS 89. THIRD BRANCHIAL CLEFT CYST: A POTENTIAL DIFFICULT RADIOLOGIC DIAGNOSIS • R. Ferrai

Mineralogy and electron microprobe studies of magnetite in the Sarab-3 iron Ore deposit, southwest of the Shahrak mining region (east Takab

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Mohammad Maanijou

2018-04-01

Full Text Available Introduction There is an iron mining complex called Shahrak 60 km east of the Takab town, NW Iran. The exploration in the Shahrak deposit (general name for all iron deposits of the area started in 1992 by the Foolad Saba Noor Co. and continued in several periods until 2008. The Shahrak deposit is comprised of 10 ore deposits including Sarab-1, Sarab-2, Sarab-3, Korkora-1, Korkora-2, Shahrak-1, Shahrak-2, Shahrak-3, Cheshmeh and Golezar deposits (Sheikhi, 1995 with a total 60 million tons of proven ore reserves. The Fe grade ranges from 45 to 65% (average 50%. The ore reserves of these deposits are different. Sarab-3 ore deposit with 9 million tons of 54% Fe and 8.95% S is located at the northeast of Kurdistan and in the Sanandaj-Sirjan structural zone at the latitude of 36°20´ and longitude of 47°32´. Materials and methods Sixty thin-polished, polished and thin sections are made for the study of mineralogy and petrology, and among them six thin-polished sections were selected for EPMA (Electron Probe Micro Analysis on magnetite and hematite. EPMA was performed using the Cameca Sx100 electron microprobe at the Iran Mineral Processing Research Center (IMPRC with wavelength-dispersive spectrometers. Results and discussion Based on field observations and petrographic studies, lithologic composition of intrusion (Miocene age ranges within the diorite-leucodiorite, monzodiorite-quartz monzodiorite, granodiorite-granite. With the intrusion of those igneous bodies into carbonate rocks of the Qom Formation, contact metamorphism was formed. The formation of Sarab-3 iron deposit occurred at the three stages of metamorphism, skarnification and supergene. Based on field geology of the deposit, it is composed of endoskarn, exoskarn including Fe ore±sulfides. At the metamorphic stage, after intrusion of intrusive bodies in carbonate rocks, recrystallization took place and marble was formed. With more crystallization of magma, evolved hydrothermal fluids

Innovations in the Poetry Form by Sheikh Sa'd od-Din Ahmad Ansari

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Najaf Jowkar

2016-05-01

the first and the second stanza is different from other lines and each stanza is separated with two lines of masnavi.  In addition, each stanza is artistically connected to the other.2.      Quatrain refrained masnavi (masnavi dobeiti tarjee'band: It has nine stanzas each separated with a quatrain.3.      Refrained tail-rhymed (mosammat mostazad trajee'band: Another one of his innovations is in refrained tail-rhymed poem. It has nine stanzas each rhyming but unrhymed with other stanzas. In each hemistich in between stanzas repeated four times. Other forms consist of tail-rhymed parallel refrain, and multiple parallel refrain discussed in detail in the paper.References1.      Ansari, Mohammad Jamal od-Din (1362. 'Ein ol-Iman.  Feiz Ahmad Decoy and Mirgirim (ed., Kabul.2.      ------------------------------------------ (1370. Shoor-e 'Eshq Divan. Habibollah Ebrahimzade (ed., Kabul: Meivand.3.      Arianpour, Yahya (1387.  From Saba to Nima and from Nima to our era. Tehran: Zavvar.4.      Bahar, Mohammad Taqi (1390. Divan of malek osh-Sho'ara Bahar. Aziz Mehdi & Tamoon Salahi (ed., Tehran: Ketab Zaman.5.      Hasani, Hamid (1371. Music of Nima’s poetry. Tehran: Ketab Zaman.6.      Homaee, Jalal od-Din. (1389. Technics of eloquence and literary figures. Tehran: Nashr Homa.7.      Isfahani. Mohammad Jamal Od-Din (1389. Divan of Mohammad Jamal od-Din. Neishaburi (ed.. Tehran: Kanon Ketab.8.      Kashefi, Habibollah (1390. Contemplation of Sheikh Sa'd od-Din Ahmad Ansari’s Mystic ideas and literary expressions in his Divan titled Passion of Love. Shiraz: University of Shiraz.9.      Khalili Jahantigh, Maryam (1380.  The Apple of spirit garden. Tehran: Sokhan.10.  Kianoosh, Mahmood (1389. Nima Yushij and Persian classic poetry, Tehran: Qatre.11.  Lahuri, Eqbal (1389. Divan of Eqbal

The Role of Allegory (Tamsil in the stories of Mathnavi Ma’navi

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Mah Nazari

2014-12-01

shepherd’s comm:::union::: with God, which is criticized by fanatics, is the exemplar of intimates and it is based on simile. Paradox forms a remarkable part of Mowlavi’s allegorical stories. It is one of devices Molana used for foregrounding utterances and also for expressing mental concepts indirectly. In the story of the far-sighted blind, the blind man sees the faults of others from a distance (but, he is blind to his own faults, the sharp hearing deaf is the symbol of yearning and greediness and the long-robed naked man is one of the deluded of this transitory world. In this anecdote, the poet has explained very briefly the story of the people of Saba who gave no thanks to God for his blessings and rebelled     In this method the poet reports the meaning of a Koranic verse either by interpreting or translating. Generally speaking, the word ‘manifestation’ refers to the manifestation of holy Koran in Mathnavi  Ma’navi.

Book Reviews

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Redactie KITLV

1995-07-01

Full Text Available -Dennis Walder, Robert D. Hamner, Derek Walcott. New York: Twayne Publishers, 1993. xvi + 199 pp.''Critical perspectives on Derek Walcott. Washington DC: Three continents, 1993. xvii + 482 pp. -Yannick Tarrieu, Lilyan Kesteloot, Black writers in French: A literary history of Negritude. Translated by Ellen Conroy Kennedy. Washington DC: Howard University Press, 1991. xxxiii + 411 pp. -Renée Larrier, Carole Boyce Davies ,Out of the Kumbla: Caribbean women and literature. Trenton NJ: Africa World Press, 1990. xxiii + 399 pp., Elaine Savory Fido (eds -Renée Larrier, Evelyn O'Callaghan, Woman version: Theoretical approaches to West Indian fiction by women. London: Macmillan Caribbean, 1993. viii + 126 pp. -Lisa Douglass, Carolyn Cooper, Noises in the blood: Orality, gender and the 'vulgar' body of Jamaican popular culture. London: Macmillan Caribbean, 1993. ix + 214 pp. -Christine G.T. Ho, Kumar Mahabir, East Indian women of Trinidad & Tobago: An annotated bibliography with photographs and ephemera. San Juan, Trinidad: Chakra, 1992. vii + 346 pp. -Eva Abraham, Richenel Ansano ,Mundu Yama Sinta Mira: Womanhood in Curacao. Eithel Martis (eds.. Curacao: Fundashon Publikashon, 1992. xii + 240 pp., Joceline Clemencia, Jeanette Cook (eds -Louis Allaire, Corrine L. Hofman, In search of the native population of pre-Colombian Saba (400-1450 A.D.: Pottery styles and their interpretations. Part one. Amsterdam: Natuurwetenschappelijke Studiekring voor het Caraïbisch Gebied, 1993. xiv + 269 pp. -Frank L. Mills, Bonham C. Richardson, The Caribbean in the wider world, 1492-1992: A regional geography. Cambridge: Cambridge University Press, 1992. xvi + 235 pp. -Frank L. Mills, Thomas D. Boswell ,The Caribbean Islands: Endless geographical diversity. New Brunswick NJ: Rutgers University Press, 1992. viii + 240 pp., Dennis Conway (eds -Alex van Stipriaan, H.W. van den Doel ,Nederland en de Nieuwe Wereld. Utrecht: Aula, 1992. 348 pp., P.C. Emmer, H.PH. Vogel (eds

Selected Lectures of the 12th International Workshop on Neonatology; Cagliari (Italy; October 19-22, 2016

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--- Various Authors

2016-10-01

Full Text Available Selected Lectures of the 12th International Workshop on Neonatology; Cagliari (Italy; October 19-22, 2016LECT 1. NEONATAL CONGENITAL HEART DISEASE: WHAT'S NEW? • S. Costa, U. BottoneLECT 2. THE PRETERM NEWBORN INFANT WITH PATENT DUCTUS ARTERIOSUS: TO TREAT IT? HOW TO MANAGE IT? WHEN TO TREAT IT? • C. CavalliLECT 3. CONGENITAL CARDIOPATHies IN CHILDREN WITH DOWN SYNDROME • P. Neroni, R. Pintus, A. Dessì, M. Carboni, S. Floris, G. Ottonello, V. FanosLECT 4. FROM FETUS TO ADULTHOOD: THE YOUNG ADULT WITH CONGENITAL HEART DISEASE (ACHD • M. Chessa, E. Conforti, A. Micheletti, D.G. Negura, L. Giugno, A. Varrica, M. Lorito, A. GiambertiLECT 5. RESEARCH NEWS IN CARDIOLOGY: FROM FETUS TO ADULT PATIENT • P.P. BassareoLECT 6. ADVANCED SIMULATION IN NEONATOLOGY, MARGIN NOTES ON A METICULOUS TAILORING JOB • A. Cuttano, R.T. Scaramuzzo, M. Ciantelli, E. Sigali, A. BoldriniLECT 7. THORACIC ULTRASOUND IN NEONATOLOGY: PRESENT AND FUTURE • D. De LucaLECT 8. MAGNETIC RESONANCE IMAGING IN NEONATAL ASPHYXIA • M. Marras, A. Lai, L. Saba, P.P. Bassareo, L. Scarciolla, D. LongoLECT 9. INTRAOSSEOUS VASCULAR ACCESS IN PRETERM NEONATES • A. Lai, V. Masile, M. MarrasLECT 10. THE EARLY GUT COLONIZATION IN NEWBORNS • G. BiasucciLECT 11. MICROBIOTA AND PROBIOTICS • M. CorpinoLECT 12. ORGANIZATION, TRAINING AND CHARACTERISTICS OF COTTOLENGO VOLUNTEERING • L. MarchisioLECT 13. HEALTH SITUATION AND EPIDEMIOLOGY IN THE COTTOLENGO'S MISSIONS • E. ScalabrinoLECT 14. MATERNAL AND CHILD SERVICES AND CARING NEEDS • I. FarnetaniLECT 15. GIVING BIRTH IN RURAL AFRICA: CHALLENGES AND ADVANCES IN A REFERRAL SITE • G. GaidoLECT 16. COTTOLENGO MISSION HOSPITAL CHAARIA (KENYA: BORN IN A BUSH HOSPITAL • R. CavalliniLECT 17. DENTISTRY IN KENYA, THE STORY OF CHAARIA • G. FarneseLECT 18. VOLUNTEERS NURSES IN CHAARIA • S. FerranteLECT 19. SURGERY IN THIRD WORLD COUNTRIES: THE EXPERIENCE OF THE COTTOLENGO MISSION HOSPITAL • V. RussoLECT 20. THE HUMAN

The Role of Allegory (Tamsil in the stories of Mathnavi Ma’navi

Directory of Open Access Journals (Sweden)

Mah Nazari

2014-11-01

exalted. In the story of “Moses and the Shepherd”, Moses is law-bringing and also has a divine mission and the shepherd’s comm:::::union::::: with God, which is criticized by fanatics, is the exemplar of intimates and it is based on simile. Paradox forms a remarkable part of Mowlavi’s allegorical stories. It is one of devices Molana used for foregrounding utterances and also for expressing mental concepts indirectly. In the story of the far-sighted blind, the blind man sees the faults of others from a distance (but, he is blind to his own faults, the sharp hearing deaf is the symbol of yearning and greediness and the long-robed naked man is one of the deluded of this transitory world. In this anecdote, the poet has explained very briefly the story of the people of Saba who gave no thanks to God for his blessings and rebelled     In this method the poet reports the meaning of a Koranic verse either by interpreting or translating. Generally speaking, the word ‘manifestation’ refers to the manifestation of holy Koran in Mathnavi  Ma’navi.