WorldWideScience

Sample records for saate mis iganes

  1. Nocturnal and Circadian Rhythm of Blood Pressure Is Associated with Renal Structure Damage and Function in Patients with IgAN.

    Science.gov (United States)

    Lin, Lirong; Zhang, Huhai; Yang, Jurong; Zhang, Jianguo; Li, Kailong; Huo, Bengang; Dai, Huanzi; Zhang, Weiwei; Yang, Jie; Tan, Wei; He, Yani

    2016-01-01

    Abnormal circadian rhythm of blood pressure (BP) is closely related to target organ damage in hypertension. However, the association between abnormal circadian rhythm of BP and renal injury is not clear. We investigated whether renal injury is associated with nocturnal BP and circadian rhythm of BP in Chinese IgAN patients. Clinic and 24 h ambulatory BP monitoring data were obtained from 330 Chinese IgAN patients with mean 24 h BP circadian BP, and 27% had nocturnal hypertension with a nondipping pattern. Compared with nocturnal normotensive patients, patients with nocturnal hypertension had significantly higher levels of blood cystatin C, blood uric acid, and lower estimated glomerular filtration rate (eGFR), and significantly a higher mean renal tissue injury score. The nondipping hypertensive group had significantly higher nocturnal diastolic and systolic BP, blood uric acid, and glomerulosclerosis rates, whereas eGFR was lower. In nondipping hypertensive patients, urinary sodium excretion and renal tissue injury scores were significantly higher than dipping patients. Nocturnal hypertension and abnormal circadian BP correlated with renal tissue injury, renal interstitial fibrosis, and aortic arch atherosclerosis. Abnormal circadian rhythm of BP and nocturnal hypertension are common clinical manifestations in Chinese IgAN patients with normal mean 24 h BP. Abnormal circadian BP and nocturnal hypertension may accelerate IgAN progression by inducing renal dysfunction and histopathological damage. Copyright © 2016 IMSS. Published by Elsevier Inc. All rights reserved.

  2. Social Awareness and Action Training (SAAT)

    Science.gov (United States)

    2014-04-01

    10. The training materials for SAAT were completed and shared with WRAIR scientists. Variations on these training materials are being prepared to...Family Psychology, 21, 572-583. Gade, P. A. (2003). Organizational commitment in the military: An overview. Military Psychology, 15, 163-166. Goldberg ...A. (2005). The impact of operations tempo on turnover intentions of Army personnel. Military Psychology, 17, 175-202. Iversen, A. C., Fear, N. T

  3. RESPON PRIMIPARA SAAT DIPUTUSKAN SECTIO CAESAREA DARURAT

    OpenAIRE

    Sari, Febria Syafyu

    2018-01-01

    Primipara yang akan menjalani persalinan secara Sectio Caesarea (SC) dapat mempengaruhi  kesiapan praoperatif saat diputuskan SC. Ketidaksiapan primipara dalam menghadapi praoperatif SC dapat meningkatkan resiko depresi postpartum. Penelitian kualitatif dengan pendekatan desain fenomenologi deskriptif yang bertujuan untuk mengeksplorasi respon pertama kali primipara pada praoperatif SC. Penelitian ini dilaksanakan pada tahun 2016 di ruang Kebidanan, dengan jumlah partisipan sebanyak enam oran...

  4. Noorukid ja narkootikumid / Helve Saat

    Index Scriptorium Estoniae

    Saat, Helve

    2000-01-01

    Artiklis on noorukiea probleemkäitumise käsitlemisel lähtutud arengupsühholoogia seisukohtadest ning toetutud 1999.a. Harjumaa keskkooliõpilaste hulgas läbi viidud empiirilisele uuringule, milles selgitati, mis tõukab noorukeid narkootikume tarbima

  5. TRAVEL TO TIME: CLOCK AND CLOCK TYPES IN DIVAN POETRY ZAMANA YOLCULUK: DİVAN ŞİİRİNDE SAAT VE SAAT ÇEŞİTLERİ

    Directory of Open Access Journals (Sweden)

    Gülay DURMAZ

    2012-06-01

    Full Text Available Measuring time has always been essential for humans. Until we had the modern day clocks, various techniques had been used, and time had been tried to be regulated. During this process many different types of clocks emerged. In this article, reflection of clock and its progress in the real world on the Divan poetry will be examined. Couplets revealing how the topic of clocks and time was held in the trips to the imaginations of the Divan poet will lead the way in this examination Zamanı ölçmek, insanoğlu için her zaman çok önemli olmuştur. Bugün kullandığımız saatlere ulaşıncaya kadar, pek çok yöntem denenmiş ve zamanın düzenlenmesine çalışılmıştır. Bu aşamada birçok saat çeşidi de ortaya çıkmıştır. Bu makalede saatin ve saat çeşitlerinin gerçek dünyadaki gelişiminin Divan şiirine yansıması izlenmeye çalışılacaktır. Bunun için Divan şairinin, hayal dünyasının yolculuğunda saat ve zaman konusuna nasıl yer verdiğini gösteren beyitler, bu konudaki yol göstericiler olacaktır.

  6. Mis\\`ere Games and Mis\\`ere Quotients

    OpenAIRE

    Siegel, Aaron N.

    2006-01-01

    These lecture notes are based on a short course on mis\\`ere quotients offered at the Weizmann Institute of Science in Rehovot, Israel, in November 2006. They include an introduction to impartial games, starting from the beginning; the basic mis\\`ere quotient construction; a proof of the Guy--Smith--Plambeck Periodicity Theorem; and statements of some recent results and open problems in the subject.

  7. Saates armastuse sõnumeid / Aita Kivi

    Index Scriptorium Estoniae

    Kivi, Aita, 1954-

    2004-01-01

    Filoloogi Mai-Liis Napa ning juristi ja kirjaniku Martin Napa perekonnast. Pereliikmete ühiseks harrastuseks on maalimine. Elatakse Lillekülas 1939. a. ehitatud majas, mis on ehitatud suuremaks ja mugavamaks. Ka Miia Masso projekteeritud talveaiast. 8 ill

  8. Justice et miséricorde

    OpenAIRE

    Heyer, René

    2012-01-01

    On n’imagine pas de justice sans possibilité de faire miséricorde ; inversement, une miséricorde qui ne tiendrait pas compte de la justice ne serait plus la miséricorde. Les deux notions sont liées, mais sur un socle inégal : car la justice inspirée par la loi naturelle déborde la justice positive, de même que la misère des miséreux ne se laisse pas ramener au mal commis par le misérable. En découlent des variations où l’on peut voir se profiler trois moments : 1. La loi coutumière est bouscu...

  9. Sensitivity of the Greenland Ice Sheet to Interglacial Climate Forcing: MIS 5e Versus MIS 11

    Science.gov (United States)

    Rachmayani, Rima; Prange, Matthias; Lunt, Daniel J.; Stone, Emma J.; Schulz, Michael

    2017-11-01

    The Greenland Ice Sheet (GrIS) is thought to have contributed substantially to high global sea levels during the interglacials of Marine Isotope Stage (MIS) 5e and 11. Geological evidence suggests that the mass loss of the GrIS was greater during the peak interglacial of MIS 11 than MIS 5e, despite a weaker boreal summer insolation. We address this conundrum by using the three-dimensional thermomechanical ice sheet model Glimmer forced by Community Climate System Model version 3 output for MIS 5e and MIS 11 interglacial time slices. Our results suggest a stronger sensitivity of the GrIS to MIS 11 climate forcing than to MIS 5e forcing. Besides stronger greenhouse gas radiative forcing, the greater MIS 11 GrIS mass loss relative to MIS 5e is attributed to a larger oceanic heat transport toward high latitudes by a stronger Atlantic meridional overturning circulation. The vigorous MIS 11 ocean overturning, in turn, is related to a stronger wind-driven salt transport from low to high latitudes promoting North Atlantic Deep Water formation. The orbital insolation forcing, which causes the ocean current anomalies, is discussed.

  10. Pengaruh Perubahan Saat Penyalaan (Ignition Timing) Terhadap Prestasi Mesin Pada Sepeda Motor 4 Langkah Dengan Bahan Bakar Lpg

    OpenAIRE

    Yunianto, Bambang

    2010-01-01

    Bahan bakar LPG merupakan bahan bakar gas yang ramah lingkungan, sehingga dapat dijadikan bahan bakar alternatif selain bahan bakar bensin Performa Mesin bensin yang dioperasikan dengan menggunakan bahan bakar gas LPG mengalami penurunan. Penurunan ini terjadi dikarenakan karakteristik sifat bahan bakar bensin berbeda dengan LPG. Hal ini dapat diatasi dengan mengatur saat penyalaan sehingga lebih sesuai dengan karakteristik gas LPG. Dari hasil pengujian diperoleh bahwa dengan pengaturan saat ...

  11. Hubungan Sumber Informasi dan Usia Remaja Puteri dengan Perilaku Perawatan Diri saat Menstruasi

    Directory of Open Access Journals (Sweden)

    Tetti Solehati

    2017-08-01

    Full Text Available Remaja putri merupakan kelompok rawan terjangkit infeksi saluran reproduksi, salah satunya disebabkan pola perilaku belum mendukung dalam perawatan diri saat menstruasi yang menyebabkan meningkatnya angka keputihan patologis. Pola perilaku seseorang dapat dipengaruhi oleh usia dan informasi. Pada pondok pesantren biasanya guru memberikan edukasi tentang kesehatan reproduksi sesuai dengan ajaran islam yang dirasakan lengkap untuk siswinya sehingga akan berpengaruh pada perilaku kesehatan reproduksi mereka. Tujuan penelitian ini untuk mengetahui hubungan sumber informasi dan usia siswi dengan perilaku perawatan diri saat menstruasi. Metode: Desain penelitian deskriptif korelasional. Teknik pengambilan sample total sampling dengan jumlah 100 siswi kelas VIII dan IX. Kegiatan: Penelitian dilakukan di Pondok Pesantren Al-Musaddadiyah Garut tahun 2016. Instrumen terdiri dari quisioner data sumber informasi dan usia, serta lembar ceklis perilaku perawatan diri saat menstruasi. Data dianalisis menggunakan analisis univariat dan bivariat. Hasil penelitian menunjukkan hampir setengahnya responden berusia 15 tahun (27%, seluruh responden (100% mendapatkan informasi, hampir seluruh responden (82% mendapatkan informasi dari ibu, dan hampir seluruh responden (87% berperilaku tidak mendukung. Hasil uji korelasi menunjukkan bahwa hanya variabel usia yang memiliki nilai signifikan terhadap perilaku perawatan diri saat menstruasi (p = 0,033, sedangkan variabel sumber informasi tidak ada yang memiliki nilai yang signifikan seperti dari; ibu (p = 1,000, koran (p = 0,767, TV (p = 0,338, internet (p = 0,296, guru (p = 0,682, teman (p = 0,675, petugas kesehatan (p = 0,208, dan informasi lainnya (p = 0,780. Kesimpulan terdapat hubungan yang bermakna antara usia dengan perilaku perawatan diri saat menstruasi. Kata kunci: Perawatan diri saat menstruasi, siswi, sumber informasi.   The Correlation between Information Source and Age of Adolscent Girls to Self Care

  12. Climate changes in south western Iberia and Mediterranean Outflow variations during two contrasting cycles of the last 1 Myrs: MIS 31-MIS 30 and MIS 12-MIS 11

    Science.gov (United States)

    Sánchez Goñi, M. F.; Llave, E.; Oliveira, D.; Naughton, F.; Desprat, S.; Ducassou, E.; Hodell, D. A.; Hernández-Molina, F. J.

    2016-01-01

    Grain size analysis and physical properties of Sites U1388, U1389 and U1390 collected in the Contourite Depositional System of the Gulf of Cádiz during the Integrated Ocean Drilling Program (IODP) Expedition 339 "Mediterranean Outflow" reveal relative changes in bottom current strength, a tracer of the dynamics of the Mediterranean Outflow Water (MOW), before and after the Middle Pleistocene Transition (MPT). The comparison of MOW behavior with climate changes identified by the pollen analysis and δ18O benthic foraminifera measurements of Site U1385, the Shackleton Site, collected in the south western Iberian margin shows that the interval MIS 31-MIS 30, ~ 1.1-1.05 million years ago (Ma), before the MPT, was marked by wetter climate and weaker bottom current than the interval MIS 12-MIS 11 (0.47-0.39 Ma), after the MPT. Similarly, the increase in fine particles from these glacials to interglacials and in coarse fraction from interglacials to glacials was coeval with forest and semi-desert expansions, respectively, indicating the lowering/enhancement of MOW strength during periods of regional increase/decrease of moisture. While these findings may not necessarily apply to all glacial/interglacial cycles, they nonetheless serve as excellent supporting examples of the hypothesis that aridification can serve as a good tracer for MOW intensity. The strongest regional aridity during MIS 12 coincides with a remarkable increase of coarse grain size deposition and distribution that we interpret as a maximum in MOW strength. This MOW intensification may have pre-conditioned the North Atlantic by increasing salinity, thereby triggering the strong resumption of the Meridional Overturning Circulation that could contribute to the great warmth that characterizes the MIS 11c super-interglacial.

  13. How Are MIS-5e And MIS-11 Different From Other Interglacials And the Future?

    Science.gov (United States)

    Yin, Q.; Berger, A.

    2017-12-01

    MIS-5e and MIS-11 appear in many proxy records as the warmest interglacials of the last million years although their astronomical configurations are very different. To investigate how they are different from other interglacials and between themselves, the climate of nine interglacials of the past 800,000 years has been simulated using both snapshot and transient experiments. These simulations allow to investigate the relative contributions of insolation and CO2 to the intensity and duration of each interglacial as well as the differences and similarities between the interglacials. The transient simulations which cover a large range of precession, obliquity and eccentricity allow to investigate the response of different climate variables and different regions to the three astronomical parameters. My presentation will focus on the characteristics of the climate forcing and response of MIS-5e and MIS-11 in comparison with the other intergalcials. Their duration and intensity at global and regional scales will be shown and the causes will be discussed. Unique features in astronomical forcing as well as in regional climate response are found in MIS-5e and MIS-11, which might help to understand why they appear to be among the warmest interglacials. The model results also show that the warm interval of MIS-11 is the longest, confirming its long duration as found in many proxy records. The long duration of MIS-11 is related to a particular combination of eccentricity, obliquity and precession as well as to its long-lasting high CO2 concentration. The differences between the seasonal behaviour of the past interglacials highlight the importance of seasonal climate reconstruction and therefore the necessity to obtain seasonal proxies. The simulated climate of MIS-5e and MIS-11 will also be compared with the climate of today and of the future to investigate the differences and similarities between the past warm conditions and the projected future warming. Part of the results

  14. The MIS 11 – MIS 1 analogy, southern European vegetation, atmospheric methane and the

    Directory of Open Access Journals (Sweden)

    P. C. Tzedakis

    2010-03-01

    Full Text Available Marine Isotope Stage (MIS 11 has been considered a potential analogue for the Holocene and its future evolution. However, a dichotomy has emerged over the precise chronological alignment of the two intervals, with one solution favouring a synchronization of the precession signal and another of the obliquity signal. The two schemes lead to different implications over the natural length of the current interglacial and the underlying causes of the evolution of greenhouse gas concentrations. Here, the close coupling observed between changes in southern European tree populations and atmospheric methane concentrations in previous interglacials is used to evaluate the natural vs. anthropogenic contribution to Holocene methane emissions and assess the two alignment schemes. Comparison of the vegetation trends in MIS 1 and MIS 11 favours a precessional alignment, which would suggest that the Holocene is nearing the end of its natural course. This, combined with the divergence between methane concentrations and temperate tree populations after 5 kyr BP, provides some support for the notion that the Holocene methane trend may be anomalous compared to previous interglacials. In contrast, comparison of MIS 1 with MIS 19, which may represent a closer astronomical analogue than MIS 11, leads to substantially different conclusions on the projected natural duration of the current interglacial and the extent of the anthropogenic contribution to the Holocene methane budget. As answers vary with the choice of analogue, resolution of these issues using past interglacials remains elusive.

  15. PENGARUH PERUBAHAN SAAT PENYALAAN (IGNITION TIMING TERHADAP PRESTASI MESIN PADA SEPEDA MOTOR 4 LANGKAH DENGAN BAHAN BAKAR LPG

    Directory of Open Access Journals (Sweden)

    Bambang Yunianto

    2012-07-01

    Full Text Available Bahan bakar LPG merupakan bahan bakar gas yang ramah lingkungan, sehingga dapat dijadikan bahan bakar alternatif selain bahan bakar bensin Performa Mesin bensin yang dioperasikan dengan menggunakan bahan bakar gas LPG mengalami penurunan. Penurunan ini terjadi dikarenakan karakteristik sifat bahan bakar bensin berbeda dengan LPG. Hal ini dapat diatasi dengan mengatur saat penyalaan sehingga lebih sesuai dengan karakteristik gas LPG. Dari hasil pengujian diperoleh bahwa dengan pengaturan saat penyalaan 11° sebelum TMA, menghasilkan prestasi (Torsi dan Daya yang dekat dengan prestasi motor bensin yaitu hanya selisih 3 %. Prestasi terbaik pada mesin bahan bakar bensin ataupun LPG berkisar pada putaran 4000 s.d 5000 rpm

  16. Soil and climate modelling to explain soil differences in MIS5e and MIS13 on the Chinese Loess Plateau

    Science.gov (United States)

    Finke, P. A.; Yu, Y.; Yin, Q.; Bernardini, N. J.

    2016-12-01

    Objective Proxy records indicate that MIS5 (about 120 ka ago) was warmer than MIS13 (about 500 ka ago). Nevertheless, MIS13-soils in the Chinese loess plateau (105 -115°E and 30-40°N) are stronger developed than MIS5-soils. This has been attributed to a stronger East Asian summer monsoon. Other differences are interglacial lengths and loess deposition rates. We aimed to find explanations for soil development differences by using a soil formation model (SoilGen) with climatic inputs obtained from an earth system model (LOVECLIM). Material and Methods The LOVECLIM model is driven by time-varying insolation and greenhouse gas concentrations and was run to give monthly values for temperature, precipitation and evaporation as well the dominant vegetation type. Model results for were corrected for systematic differences between present-day observation data and simulation. Reconstructions were made for both interglacials of the amount of inblown loess, and the mineralogy and grain size distribution of the initial loess as well as the dust. These data were fed into the SoilGen model, which was used to calculate various soil parameters with depth and over time. Results Simulations show a stronger developed MIS13 soil, in terms of weathering (loss of anorthite), and redistribution of calcite, gypsum and clay. This corresponds to observed paleosoils. MIS13-soils are more leached. As simulated temperatures and annual precipitation between MIS5 and MIS13 did not vary strongly, the greater length of MIS13 seemed the main explanation for the stronger leaching and weathering. Closer analysis however showed a larger number of months in MIS13 with a precipitation surplus, even when only considering the first 22 ka. Only in such months significant leaching can occur. Conclusion Using simulation models it was demonstrated that the stronger soil expression in MIS13 than in MIS5 is likely caused by more months with a precipitation surplus, in combination with a longer duration of MIS

  17. VAKSIN DENGUE DAN PERKEMBANGANNYA SAAT INI DAN DI MASA MENDATANG

    Directory of Open Access Journals (Sweden)

    Triwibowo Ambar Garjito

    2012-09-01

    Full Text Available Dengue virus merupakan salah satu virus anggota dari famili Flaviviridae yang sejak tahun 1956 telah dikenal dapat menimbulkan demam dengue maupun demam berdarah dengue (DBD. Penyakit yang ditularkan oleh nyamuk Aedes aegypti ini diperkirakan telah menjangkiti pada selatar 50-100 juta manusia dengan 500.000 kasus di antaranya dalam manifestasi yang ganas yang dikenal sebagai dengue haemorrhagic fever dan dengue shock syndrome dan 25.000 di antaranya berakibat fatal (meninggal. Saat ini pengembangan vaksin merupakan salah satu solusi yang diharapkan dapat menekan penyebaran penyakit tersebut. E (envelope merupakan salah satu bagian dari protein struktural virus yang sangat penting dalam pengembangan vaksin, yaitu sebagai badan yang memproduksi antibodi netralisasi untuk protein. Non-struktural protein l juga telah diketahui sebagai salah satu komponen penting dalam pengembangan vaksin oleh karena kemampuannya untuk dapat diekspresi pada permukaan sel yang diinfeksi yang dapat menjadi target untuk immune cytolisis. Ada dua pendekatan yang digunakan dalam memproduksi suatu vaksin dengue, yaitu: a. Vaksin hidup yang telah dilemahkan (live attenuated vaccine: b. Vaksin hasil rekayasa (engineered vaccine. Penelitian terhadap vaksin DENV baik rekombinan maupun non-rekombinan yang didasarkan pada uji virus telah dilakukan secara terus-menerus baik pada monyet dan manusia. Sampai saat ini telah dikembangkan sejumlah kandidat vaksin DENV yang berdasar pada tetravalent virus dengue, yaitu a. vaksin konvensional, b. vaksin dengue rekombinan berdasar pada flavivirus, c. vaksin intertypic chimeric, d. vaksin chimerivac, e. vaksin dengue rekombinan menggunakan vector non-ftavivirus dan f. vector adenovirus. Namun demikian, sampai sekarang belum ada vaksin yang siap digunakan untuk menangkal infeksi ke empat serotype virus dengue, sehingga masih diharapkan untuk pengembangan virus lebih lanjut.   Kata kunci: Aedes aegypti, dengue virus, vaksin dengue.

  18. Quantitative reconstruction of precipitation and runoff during MIS 5a, MIS 3a, and Holocene, arid China

    Science.gov (United States)

    Liu, Yuan; Li, Yu

    2017-11-01

    Marine oxygen isotope stage 5a (MIS 5a), MIS 3a, and Holocene were highlighted periods in paleoclimate studies. Many scientists have published a great number of studies in this regard, but they paid more attention to qualitative research, and there was often a lack of quantitative data. In this paper, based on chronological evidence from a paleolake in arid China, MIS 5a, MIS 3a, and Holocene lake area, the precipitation of the drainage area and the runoff of the inflowing rivers of the lake were reconstructed with ArcGIS spatial analysis software and the improved water and energy balance model which was calibrated by modern meteorological and hydrological data in the Shiyang River drainage basin. The results showed that the paleolake areas were 1824, 1124, and 628 km2 for MIS 5a, MIS 3a, and Holocene; meanwhile, the paleoprecipitation and runoff were 293.992-297.433, 271.105-274.294, and 249.431-252.373 mm and 29.103 × 108-29.496 × 108, 18.810 × 108-18.959 × 108, and 10.637 × 108-10.777 × 108 mm, respectively. The quantitative data can help us not only strengthen the understanding of paleoclimatic characteristics but also recognize the complexity and diversity of the climate system.

  19. PENENTUAN HARGA JUAL KAMAR HOTEL SAAT LOW SEASON DENGAN METODE COST-PLUS PRICING PENDEKATAN VARIABEL COSTING (Studi kasus pada Hotel Puri Artha Yogyakarta)

    OpenAIRE

    Triyanto, Hesti

    2013-01-01

    Penentuan harga jual suatu produk atau jasa merupakan salah satu keputusan penting manajemen karena harga yang ditetapkan harus dapat menutup semua biaya dan mendapatkan laba yang diharapkan oleh perusahaan. Pada saat low season, pihak hotel menerapkan harga jual yang paling rendah dalam penentuan harga jualnya agar pihak hotel tidak mengalami kerugian. Penelitian ini bertujuan untuk mengetahui berapa tarif sewa kamar dan selisih tarif sewa kamar Hotel Puri Artha Yogyakarta pada saat low seas...

  20. Young PM candidate harsh criticism / Talis Saule Archdeacon

    Index Scriptorium Estoniae

    Archdeacon, Talis Saule

    2007-01-01

    Läti Rahvaerakonna peaministrikandidaati Edgars Zalansit süüdistatakse kogemuste puudumises. Edgars Zalans ei kavatse osaleda tuntud teleajakirjaniku Janis Dombursi saates "Mis toimub Lätis?". Teised kandidaadid peaministri kohale

  1. Mis on õiglane kaubandus? / Riina Kuusik ; interv. Inge Pitsner

    Index Scriptorium Estoniae

    Kuusik, Riina

    2006-01-01

    ETV saate "Tasakaal" tegijad külastasid Nicaraguat ja Costa Ricat, et vaadata, kuidas elavad ja töötavad "õiglase kaubanduse" süsteemi kuuluvad talunikud, õiglase kaubanduse (fairtrade) mõistest

  2. Meeldis. Mõjus. Mis edasi? / Mati Unt

    Index Scriptorium Estoniae

    Unt, Mati, 1944-2005

    2004-01-01

    Artiklis räägitakse peamiselt Evald Hermaküla lavastusest "Tuul Olümposelt tuhka tõi" (Eesti Draamateater, 1986), mis pakkus Mati Undile toona viimase aja suurima teatrielamuse, aga ka sellest, et teatrisemiootikud pole senini saavutanud üksmeelt, mis on ikkagi etenduse segment

  3. Mis on Eesti hariduse eesmärk? / Enn Vatter

    Index Scriptorium Estoniae

    Vatter, Enn

    2003-01-01

    Autori arvates ei suudeta valimiseelsetes vaidlustes kokku leppida eelistusis hariduselus. Autor küsib, mis kooli- ja haridustemaatikas peaeesmärk ning mis on alameesmärgid, mis enne peaeesmärgi saavutamist on vaja kätte saada

  4. A MIS 9/MIS 8 speleothem record of hydrological variability from Macedonia (F.Y.R.O.M.)

    Science.gov (United States)

    Regattieri, Eleonora; Zanchetta, Giovanni; Isola, Ilaria; Bajo, Petra; Perchiazzi, Natale; Drysdale, Russell N.; Boschi, Chiara; Hellstrom, John C.; Francke, Alexander; Wagner, Bernd

    2018-03-01

    The period corresponding to Marine Isotope Stages 9 (MIS 9) offers the opportunity to study orbital and sub-orbital scale climate variability under boundary conditions different from those of better studied intervals such as the Holocene and the Last Interglacial. Yet, it is poorly represented in independently-dated continental archives around the Mediterranean Region. Here, we present a speleothem stable isotope record (δ18O and δ13C) from the Former Yugoslavian Republic of Macedonia (F.Y.R.O.M., southern Balkans), which consists of two periods of growth broadly covering the ca. 332 to 292 ka and the ca. 264 to 248 ka intervals (MIS 9e-b and late MIS 8). We interpret the speleothem δ18O as mostly related to regional hydrology, with variations that can be interpreted as due to changes in rainfall amount, with higher/lower values associated to drier/wetter condition. This interpretation is corroborated by a change in mineralogical composition between aragonite and calcite at ca. 328 ka, which marks increasing precipitation at the onset of MIS 9 and occurs within a trend of decreasing δ18O values. Also the comparison with the multiproxy climate record available from the nearby Lake Ohrid seems to support the proposed interpretation. The MIS 9e interglacial appears to be characterized by wettest conditions between ca. 326 and 321 ka, i.e. lasting ca. 5 kyr. Decreasing precipitation and enhanced millennial scale variability matches the glacial inception (MIS9 d to b), with drier events at ca. 319 ka (ca. 2 kyr long) and 310 ka (ca. 1 kyr long), and a major rainfall reduction between 306 and 298 ka. The latter is followed by a prominent wetter period between 298 and 295 ka, for which carbon data values suggest high infiltration rate. Rainfall decreases again after 295 ka, and remain low until the growth interruption at ca. 292 ka. Resumption of the growth and progressive soil development, expressed by the carbon isotope record, occurred during the late part of MIS 8

  5. Different nature of glacial CaCO3 constituents between MIS 2 and MIS 12 in the East Sea/Japan Sea and its paleoceanographic implication

    Science.gov (United States)

    Khim, Boo-Keun; Tada, Ryuji; Itaki, Takuya

    2014-05-01

    Two piston cores (PC-05 and PC-08) were collected on the Yamato Rise in the East Sea/Japan Sea during the KR07-12 cruise. A composite core was achieved with the successful replacement of almost half of the upper part of core PC-05 by the entirety of core PC-08 based on the co-equivalence of L* values and the dark layers, because an interval (170 cm to 410 cm) of core PC-05 was considerably disturbed due to fluidization during the core execution. Chronostratigraphy of the composite core was constructed by the direct comparison of L* values to the well-dated core MD01-2407 that was obtained in the Oki Ridge. The lower-bottom of the composite core reached back to Marine Isotope Stage (MIS) 14, based on the age estimate by LR04 stacks. Downcore opal variation of the composite core exhibited the distinct orbital-scale cyclic changes; high during the interglacial and low during the glacial periods. However, downcore CaCO3 variation showed no corresponding orbital-scale cyclic change between glacial and interglacial periods. Some intervals of both periods were high in CaCO3 content. Frequent and large fluctuations in CaCO3 content seemed to be more related to the presence of dark layers containing thin lamination (TL) within the glacial and interglacial intervals. It is worthy to note that MIS 2 and MIS 12 are characterized by distinctly high CaCO3 content, showing up to 18% and 73%, respectively, among the glacial periods. Furthermore, in terms of lithology, MIS 2 was characterized by a thick dark layer (low L* values) with TL, whereas MIS 12 preserved the distinctly light layer (high L* values) with parallel laminations. Another remarkable dissimilarity between MIS 2 and MIS 12 was the nature of their CaCO3 constituent; the CaCO3 constituent of MIS 2 consisted of mostly planktonic foraminifera, whereas that of MIS 12 was mostly dump of coccolithophorids, regardless the presence of planktonic foraminifera. The distinctness of the CaCO3 constituents between MIS 2 and MIS

  6. An MIS 5a/b to MIS 3 bog sequence from Henderson Bay, northern New Zealand

    International Nuclear Information System (INIS)

    D'Costa, D.; Wallis, I.

    2011-01-01

    A discontinuous Late Pleistocene pollen record from an eroding coastal cliff section at Henderson Bay on the east coast of Northland, New Zealand, reveals changes in vegetation composition and associated palaeosol development under both stadial and interstadial climatic conditions ascribed to the last interglacial-glacial cycle, probably MIS (Marine Isotope Stage) 5a/b to early MIS 3. An increase in charcoal towards the top of the sequence is believed to be due to natural rather than anthropogenic ignition sources which resulted in the development of scrub rather than forest vegetation. The sequence is capped by gravel previously inferred to have been emplaced by tsunami event(s) some time after early MIS 3. A lack of Agathis pollen in our sequence despite unequivocal evidence for the parent trees (gum) strengthens a call for caution when inferring climatic conditions from the abundance of Agathis pollen in New Zealand pollen records. (author). 32 refs., 5 figs.

  7. Exploring Pair Programming Benefits for MIS Majors

    Directory of Open Access Journals (Sweden)

    April H. Reed

    2016-12-01

    Full Text Available Pair programming is a collaborative programming practice that places participants in dyads, working in tandem at one computer to complete programming assignments. Pair programming studies with Computer Science (CS and Software Engineering (SE majors have identified benefits such as technical productivity, program/design quality, academic performance, and increased satisfaction for their participants. In this paper, pair programming is studied with Management Information Systems (MIS majors, who (unlike CS and SE majors taking several programming courses typically take only one programming course and often struggle to develop advanced programming skills within that single course. The researchers conducted two pair programming experiments in an introductory software development course for MIS majors over three semesters to determine if pair programming could enhance learning for MIS students. The program results, researchers’ direct observations, and participants’ responses to a survey questionnaire were analyzed after each experiment. The results indicate that pair programming appears to be beneficial to MIS students’ technical productivity and program design quality, specifically the ability to create programs using high-level concepts. Additionally, results confirmed increased student satisfaction and reduced frustration, as the pairs worked collaboratively to produce a program while actively communicating and enjoying the process.

  8. Misjoniseminar Tartus / Rein Kalmus, Janos Kovacs Biro, Rein Käsk...[jt.] ; interv. Mare Pihlak

    Index Scriptorium Estoniae

    2007-01-01

    Vestlus osalejatega Pereraadio saates "Elupuu," mis valmis märtsis Trans-Euroopa Divisjoni väikegruppide ja misjonitöö juhi Janos Kovacs-Biro Tartu Ülikooli Ajaloomuuseumis peetud loengusarja "Ela oma elu täiel määral" põhjal

  9. (Mis)perceptions of inequality.

    Science.gov (United States)

    Hauser, Oliver P; Norton, Michael I

    2017-12-01

    Laypeople's beliefs about the current distribution of outcomes such as income and wealth in their country influence their attitudes toward issues ranging from taxation to healthcare - but how accurate are these beliefs? We review the burgeoning literature on (mis)perceptions of inequality. First, we show that people on average misperceive current levels of inequality, typically underestimating the extent of inequality in their country. Second, we delineate potential causes of these misperceptions, including people's overreliance on cues from their local environment, leading to their erroneous beliefs about both the overall distributions of wealth and income and their place in those distributions. Third, we document that these (mis)perceptions of inequality - but not actual levels of inequality - drive behavior and preferences for redistribution. More promisingly, we review research suggesting that correcting misperceptions influences preferences and policy outcomes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. BatMis: a fast algorithm for k-mismatch mapping.

    Science.gov (United States)

    Tennakoon, Chandana; Purbojati, Rikky W; Sung, Wing-Kin

    2012-08-15

    Second-generation sequencing (SGS) generates millions of reads that need to be aligned to a reference genome allowing errors. Although current aligners can efficiently map reads allowing a small number of mismatches, they are not well suited for handling a large number of mismatches. The efficiency of aligners can be improved using various heuristics, but the sensitivity and accuracy of the alignments are sacrificed. In this article, we introduce Basic Alignment tool for Mismatches (BatMis)--an efficient method to align short reads to a reference allowing k mismatches. BatMis is a Burrows-Wheeler transformation based aligner that uses a seed and extend approach, and it is an exact method. Benchmark tests show that BatMis performs better than competing aligners in solving the k-mismatch problem. Furthermore, it can compete favorably even when compared with the heuristic modes of the other aligners. BatMis is a useful alternative for applications where fast k-mismatch mappings, unique mappings or multiple mappings of SGS data are required. BatMis is written in C/C++ and is freely available from http://code.google.com/p/batmis/

  11. A multi-proxy record of MIS 11-12 deglaciation and glacial MIS 12 instability from the Sulmona basin (central Italy)

    Science.gov (United States)

    Regattieri, Eleonora; Giaccio, Biagio; Galli, Paolo; Nomade, Sebastien; Peronace, Edoardo; Messina, Paolo; Sposato, Andrea; Boschi, Chiara; Gemelli, Maurizio

    2016-01-01

    A multi-proxy record (lithology, XRF, CaCO3 content, carbonate δ18O and δ13C) was acquired from a sediment core drilled in the intermountain Sulmona basin (central Italy). Tephrostratigraphic analyses of three volcanic ash layers ascribe the investigated succession to the MIS 12-MIS 11 period, spanning the interval ca. 500-410 ka. Litho-pedo facies assemblage indicates predominant lacustrine deposition, interrupted by a minor sub-aerial and lake low stand episode. Variations in major and minor elements concentrations are related to changes in the clastic input to the lake. The oxygen isotopic composition of carbonate (δ18Oc) intervals is interpreted mainly as a proxy for the amount of precipitation in the high-altitude catchment of the karst recharge system. The record shows pronounced hydrological variability at orbital and millennial time-scales, which appears closely related to the Northern Hemisphere summer insolation pattern and replicates North Atlantic and west Mediterranean Sea Surface Temperature (SST) fluctuations. The MIS 12 glacial inception is marked by an abrupt reduction of precipitation, lowering of the lake level and enhanced catchment erosion. A well-defined and isotopically prominent interstadial with increased precipitation maybe related to insolation maxima-precession minima at ca. 465 ka. This interstadial ends abruptly at ca. 457 ka and it is followed by a phase of strong short-term instability. Drastic lake-level lowering and enhanced clastic flux characterized the MIS 12 glacial maximum. Lacustrine deposition restarted about 440 ka ago. The MIS 12-MIS 11 transition is characterized by a rapid increase in the precipitation, lake-level rise and reduction in the clastic input, interrupted by a short and abrupt return to drier conditions. Comparison with marine records from the Iberian margin and western Mediterranean suggests that major events of ice rafted debris deposition, related to southward migrations of the polar front, match the

  12. MISCO: A Conceptual Model for MIS Implementation in SMEs

    Directory of Open Access Journals (Sweden)

    R.Bali

    1999-01-01

    Full Text Available Information Technology ('IT' has made a prolific impact, both in sociological and commercial terms. In the business world, the pursuit of new technology and working practices has often been at the expense of equal regard for the correct methods to manage the new technology. Contemporary IT techniques and methods include Management Information Systems ('MIS' which are normally implemented on a company-wide basis. However, MIS implementation has major cultural and organisational implications which will form the main focus of this paper. A conceptual model is proposed for successful MIS implementation which combines established research findings with ethnographically-informed data from a small, UK-based, business.

  13. Space Station Furnace Facility Management Information System (SSFF-MIS) Development

    Science.gov (United States)

    Mead, Robert M.

    1996-01-01

    Thios report summarizes the chronology, results, and lessons learned from the development of the SSFF-MIS. This system has been nearly two years in development and has yielded some valuable insights into specialized MIS development. Attachment A contains additions, corrections, and deletions by the COTR.

  14. SAGES's advanced GI/MIS fellowship curriculum pilot project.

    Science.gov (United States)

    Weis, Joshua J; Goldblatt, Matthew; Pryor, Aurora; Dunkin, Brian J; Brunt, L Michael; Jones, Daniel B; Scott, Daniel J

    2018-06-01

    The American health care system faces deficits in quality and quantity of surgeons. SAGES is a major stakeholder in surgical fellowship training and is responsible for defining the curriculum for the Advanced GI/MIS fellowship. SAGES leadership is actively adapting this curriculum. The process of reform began in 2014 through a series of iterative meetings and discussions. A working group within the Resident and Fellow Training Committee reviewed case log data from 2012 to 2015. These data were used to propose new criteria designed to provide adequate exposure to core content. The working group also proposed using video assessment of an MIS case to provide objective assessment of competency. Case log data were available for 326 fellows with a total of 85,154 cases logged (median 227 per fellow). The working group proposed new criteria starting with minimum case volumes for five defined categories including foregut (20), bariatrics (25), inguinal hernia (10), ventral hernia (10), and solid organ/colon/thoracic (10). Fellows are expected to perform an additional 75 complex MIS cases of any category for a total of 150 required cases overall. The proposal also included a minimum volume of flexible endoscopy (50) and submission of an MIS foregut case for video assessment. The new criteria more clearly defined which surgeon roles count for major credit within individual categories. Fourteen fellowships volunteered to pilot these new criteria for the 2017-2018 academic year. The new SAGES Advanced GI/MIS fellowship has been crafted to better define the core content that should be contained in these fellowships, while still allowing sufficient heterogeneity so that individual learners can tailor their training to specific areas of interest. The criteria also introduce innovative, evidence-based methods for assessing competency. Pending the results of the pilot program, SAGES will consider broad implementation of the new fellowship criteria.

  15. Perceived Requirements of MIS Curriculum Implementation in Bilingual Developing Countries

    Science.gov (United States)

    Kabeil, Magdy M.

    2005-01-01

    This paper addresses additional requirements associated with implementing a standard curriculum of Management Information Systems (MIS) in bilingual developing countries where both students and workplace users speak English as a second language. In such countries, MIS graduates are required to develop bilingual computer applications and to…

  16. INVESTIGATION OF MIS ITEM 011589A AND 3013 CONTAINERS HAVING SIMILAR CHARACTERISTICS

    Energy Technology Data Exchange (ETDEWEB)

    Friday, G

    2006-08-23

    Recent testing has identified the presence of hydrogen and oxygen in MIS Item 011589A. This isolated observation has effectuated concern regarding the potential for flammable gas mixtures in containers in the storage inventory. This study examines the known physicochemical characteristics of MIS Item 011589A and queries the ISP Database for items that are most similar or potentially similar. Items identified as most similar are believed to have the highest probability of being chemically and structurally identical to MIS Item 011589A. Items identified as potentially like MIS Item 011589A have some attributes in common, have the potential to generate gases, but have a lower probability of having similar gas generating characteristics. MIS Item 011589A is an oxide that was generated prior to 1990 at Rocky Flats in Building 707. It was associated with foundry processing and had an actinide assay of approximately 77%. Prompt gamma analysis of MIS Item 011589A indicated the presence of chloride, fluorine, magnesium, sodium, and aluminum. Queries based on MIS representation classification and process of origin were applied to the ISP Database. Evaluation criteria included binning classification (i.e., innocuous, pressure, or pressure and corrosion), availability of prompt gamma analyses, presence of chlorine and magnesium, percentage of chlorine by weight, peak ratios (i.e., Na:Cl and Mg:Na), moisture, and percent assay. These queries identified 15 items that were most similar and 106 items that were potentially like MIS Item 011589A. Although these queries identified containers that could potentially generate flammable gases, verification and confirmation can only be accomplished by destructive evaluation and testing of containers from the storage inventory.

  17. Sales controlling comes into view. MIS (management information system) Deutschland GmbH fits energy suppliers; Vertriebscontrolling in Sicht. MIS Deutschland GmbH macht Energieversorger fit

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2002-03-01

    MIS has integrated Microsoft-Excel efficiently, so appliers must not change other systems, can utilize advantages and know how and further functionalities like optimization of planning processes, automation of data processing, generation of a data base with structured information of energy data are available for customers.(GL) [German] Die MIS Deutschland GmbH wurde 1988 gegruendet. Die Gruender waren Studenten der Universitaet Darmstadt. Einer von ihnen ist noch heute Vorstandsvorsitzender der MIS AG. Schon damals hatte man die Vision, Manager oder die Entscheidungstraeger in Unternehmen mit Informationen zu versorgen und in die Lage zu versetzen, diese auch nach ihren Beduerfnissen auswerten, analysieren und reporten zu koennen. Dadurch entstand 1988 in Zusammenarbeit mit Microsoft die erste Microsoft-Excel-Konferenz in Deutschland. MIS hat Microsoft-Excel leistungsfaehig integriert, sodass der Anwender nicht auf ein anderes System umlernen muss, sondern die Vorteile und das Know-how Weiterverwenden kann und zusaetzlich weitere Funktionalitaeten zur Verfuegung gestellt bekommt. (orig.)

  18. West Bank Gaza Geo-MIS System

    Data.gov (United States)

    US Agency for International Development — The Geo-MIS System is USAID/West Bank and Gaza's primary system for capturing and managing projectrelated information. Its purpose is to assist USAID and its...

  19. Mis on rahuks vaja? / Harri Mõtsnik

    Index Scriptorium Estoniae

    Mõtsnik, Harri, 1928-2013

    1984-01-01

    Sisu : Mis on patt?; Ainult armust; Ainult usust;Vabadus ja tõde; Eesti rahva armukatsumisaeg; Ustavus ja valvsus; Jumal ja mammona; Eesti isesesvusele mõeldes; Elu matkatee; Elagem rahus; Õiglus ja kohus; Piiblist

  20. C-V characterization of Schottky- and MIS-gate SiGe/Si HEMT structures

    International Nuclear Information System (INIS)

    Onojima, Norio; Kasamatsu, Akihumi; Hirose, Nobumitsu; Mimura, Takashi; Matsui, Toshiaki

    2008-01-01

    Electrical properties of Schottky- and metal-insulator-semiconductor (MIS)-gate SiGe/Si high electron mobility transistors (HEMTs) were investigated with capacitance-voltage (C-V) measurements. The MIS-gate HEMT structure was fabricated using a SiN gate insulator formed by catalytic chemical vapor deposition (Cat-CVD). The Cat-CVD SiN thin film (5 nm) was found to be an effective gate insulator with good gate controllability and dielectric properties. We previously investigated device characteristics of sub-100-nm-gate-length Schottky- and MIS-gate HEMTs, and reported that the MIS-gate device had larger maximum drain current density and transconductance (g m ) than the Schottky-gate device. The radio frequency (RF) measurement of the MIS-gate device, however, showed a relatively lower current gain cutoff frequency f T compared with that of the Schottky-gate device. In this study, C-V characterization of the MIS-gate HEMT structure demonstrated that two electron transport channels existed, one at the SiGe/Si buried channel and the other at the SiN/Si surface channel

  1. C-V characterization of Schottky- and MIS-gate SiGe/Si HEMT structures

    Energy Technology Data Exchange (ETDEWEB)

    Onojima, Norio [National Institute of Information and Communications Technology (NICT), Koganei, Tokyo 184-8795 (Japan)], E-mail: nonojima@nict.go.jp; Kasamatsu, Akihumi; Hirose, Nobumitsu [National Institute of Information and Communications Technology (NICT), Koganei, Tokyo 184-8795 (Japan); Mimura, Takashi [National Institute of Information and Communications Technology (NICT), Koganei, Tokyo 184-8795 (Japan); Fujitsu Laboratories Ltd., Atsugi, Kanagawa 243-0197 (Japan); Matsui, Toshiaki [National Institute of Information and Communications Technology (NICT), Koganei, Tokyo 184-8795 (Japan)

    2008-07-30

    Electrical properties of Schottky- and metal-insulator-semiconductor (MIS)-gate SiGe/Si high electron mobility transistors (HEMTs) were investigated with capacitance-voltage (C-V) measurements. The MIS-gate HEMT structure was fabricated using a SiN gate insulator formed by catalytic chemical vapor deposition (Cat-CVD). The Cat-CVD SiN thin film (5 nm) was found to be an effective gate insulator with good gate controllability and dielectric properties. We previously investigated device characteristics of sub-100-nm-gate-length Schottky- and MIS-gate HEMTs, and reported that the MIS-gate device had larger maximum drain current density and transconductance (g{sub m}) than the Schottky-gate device. The radio frequency (RF) measurement of the MIS-gate device, however, showed a relatively lower current gain cutoff frequency f{sub T} compared with that of the Schottky-gate device. In this study, C-V characterization of the MIS-gate HEMT structure demonstrated that two electron transport channels existed, one at the SiGe/Si buried channel and the other at the SiN/Si surface channel.

  2. Depositional and sea-level history from MIS 6 (Termination II) to MIS 3 on the southern continental shelf of South Africa

    Science.gov (United States)

    Cawthra, H. C.; Jacobs, Z.; Compton, J. S.; Fisher, E. C.; Karkanas, P.; Marean, C. W.

    2018-02-01

    Pleistocene shoreline deposits comprised of calcified shallow marine (palaeobeach) and aeolian (palaeodune) facies found along mid-latitude coastlines can be useful indicators of past sea levels. Here, we describe a succession of such deposits that are presently exposed both above (subaerial) and below (submerged) mean sea level along the southern Cape coast of South Africa, 18 km east of the town of Mossel Bay. The submerged units provide a window on Late Pleistocene coastal processes, as palaeoshoreline deposits in this study extend to water depths of up to 55 m on the mid-shelf. Five sedimentary facies were identified in the strata and were compared to modern depositional environments of the local littoral zone, which include aeolian dune, upper shoreface, foreshore, intertidal swash and back-barrier settings. Twenty-two geological units were observed and mapped. Some of these units were directly dated with optically stimulated luminescence (OSL) dating. OSL ages were obtained for ten samples from the subaerial and twelve samples from the submerged deposits. Those geological units not directly dated were interpreted based on sedimentology and field/stratigraphic relationships to dated units. The stratigraphy and chronology of the succession indicates a record of initial deposition during Termination II (T-II) meltwater events, preceding and leading to marine isotope stage (MIS) 5e. Indicators for multiple sea-level fluctuations between MIS 5d and MIS 4, and sediment deposition at the end of MIS 4 and start of MIS 3 are also found. Both regressive and transgressive depositional cycles are well-preserved in the succession. We propose that palaeodune and palaeobeach deposits along the South Coast of South Africa have no clear preference for deposition during sea-level transgressions or regressions. Sediment deposition more closely mirrors the rate of sea level change, with deposition and preservation either during times of rapid sea-level movement, or oscillation

  3. Mis on mustad kirjutised? / Maie Tuulik

    Index Scriptorium Estoniae

    Tuulik, Maie, 1941-

    2011-01-01

    Mustad kirjutised on Cambridge'i ja Oxfordi kirjandusteadlaste kriitilised kirjutised sõjajärgsetel aastatel Inglismaal poolehoidu pälvinud informaalse kooli ohtudest. Eesti praegustest kasvatusseisukohtadest ja haridusteooriatest, milles domineerib lapsekesksus, mis paraku ei vii soovitud eesmärkideni

  4. Photic zone changes in the north-west Pacific Ocean from MIS 4–5e

    Directory of Open Access Journals (Sweden)

    G. E. A. Swann

    2015-01-01

    Full Text Available In comparison to other sectors of the marine system, the palaeoceanography of the subarctic North Pacific Ocean is poorly constrained. New diatom isotope records of δ13C, δ18O, δ30Si (δ13Cdiatom, δ18Odiatom, and δ30Sidiatom are presented alongside existing geochemical and isotope records to document changes in photic zone conditions, including nutrient supply and the efficiency of the soft-tissue biological pump, between Marine Isotope Stage (MIS 4 and MIS 5e. Peaks in opal productivity in MIS 5b/c and MIS 5e are both associated with the breakdown of the regional halocline stratification and increased nutrient supply to the photic zone. Whereas the MIS 5e peak is associated with low rates of nutrient utilisation, the MIS 5b/c peak is associated with significantly higher rates of nutrient utilisation. Both peaks, together with other smaller increases in productivity in MIS 4 and 5a, culminate with a significant increase in freshwater input which strengthens/re-establishes the halocline and limits further upwelling of sub-surface waters to the photic zone. Whilst δ30Sidiatom and previously published records of diatom δ15N (δ15Ndiatom (Brunelle et al., 2007, 2010 show similar trends until the latter half of MIS 5a, the records become anti-correlated after this juncture and into MIS 4, suggesting a possible change in photic zone state such as may occur with a shift to iron or silicon limitation.

  5. Mis on filosoofia?

    Directory of Open Access Journals (Sweden)

    Indrek Reiland

    2009-05-01

    Full Text Available Minu eesmärgiks antud artiklis on pakkuda üht vaadet filosoofia olemuse, eesmärgi ja rolli kohta kaasaja maailmas. Artikli esimeses osas kirjeldan lühidalt nelja tänapäeva filosoofiat oluliselt mõjutanud filosoofiakontseptsiooni: ideaalkeele traditsiooni filosoofiamõistmist, tavakeele filosoofia arusaamu, Wittgensteini terapeutilis-deflatsionalistlikku kontseptsiooni ning kaasaegse filosoofilise naturalismi metafilosoofiat. Teises osas visandan Wilfrid Sellarsist inspireerituna filosoofiamõistmise, mis võimaldab meil näha kõiki eelnevalt käsitletud filosoofiakontseptsioone täitmas ühe ja sama projekti erinevaid osi ning mõista keskset osa kaasaja filosoofiast.

  6. RESPON PRIMIPARA SAAT DIPUTUSKAN SECTIO CAESAREA DARURAT

    Directory of Open Access Journals (Sweden)

    Febria Syafyu Sari

    2018-03-01

    Full Text Available Primipara yang akan menjalani persalinan secara Sectio Caesarea (SC dapat mempengaruhi  kesiapan praoperatif saat diputuskan SC. Ketidaksiapan primipara dalam menghadapi praoperatif SC dapat meningkatkan resiko depresi postpartum. Penelitian kualitatif dengan pendekatan desain fenomenologi deskriptif yang bertujuan untuk mengeksplorasi respon pertama kali primipara pada praoperatif SC. Penelitian ini dilaksanakan pada tahun 2016 di ruang Kebidanan, dengan jumlah partisipan sebanyak enam orang yaitu enam pasien SC darurat. Hasil penelitian ini dianalisis menggunakan metode Collaizi. Etika yang diperhatikan dalam penelitian ini dengan menghormati prinsip etik penelitian dan keabsahan data memperhatikan kriteria: credibility, transferability, dependability dan confirmability. Didapatkan hasil penelitian yaitu respon fisik dan psikologis. Hasil penelitian ini dapat disimpulkan bahwa hampir keseluruhan partisipan  mengalami kecemasan. Partisipan berusaha mendekatkan diri pada Tuhan, berdoa dan berserah diri  sehingga tidak terbentuk koping yang mal adaptif.  Saran untuk petugas kesehatan dapat melakukan asuhan keperawatan psikososial sehingga dapat menanamkan kepercayaan kepada ibu yang akan melakukan persalinan SC dan dapat  menurunkan kecemasan Primiparas who will undergo cesarean delivery by Caesarea (CS may affect preoperative preparedness when the CS is decided. Primiparous unpreparedness in the face of preoperative CS may increase the risk of postpartum depression. Qualitative research with descriptive phenomenology design approach aimed to explore primitive experience on CS preoperative. The study was conducted in January - July 2016 in Midwifery room, with six participants, six emergency CS patients. The results of this study were analyzed using the Collaizi method. Ethics is considered in this study with respect to the principles of research ethics and data validity pay attention to the criteria: credibility, transferability

  7. MIS-11 duration key to disappearance of the Greenland ice sheet

    Science.gov (United States)

    Robinson, Alexander; Alvarez-Solas, Jorge; Calov, Reinhard; Ganopolski, Andrey; Montoya, Marisa

    2017-07-01

    Palaeo data suggest that Greenland must have been largely ice free during Marine Isotope Stage 11 (MIS-11). However, regional summer insolation anomalies were modest during this time compared to MIS-5e, when the Greenland ice sheet likely lost less volume. Thus it remains unclear how such conditions led to an almost complete disappearance of the ice sheet. Here we use transient climate-ice sheet simulations to simultaneously constrain estimates of regional temperature anomalies and Greenland's contribution to the MIS-11 sea-level highstand. We find that Greenland contributed 6.1 m (3.9-7.0 m, 95% credible interval) to sea level, ~7 kyr after the peak in regional summer temperature anomalies of 2.8 °C (2.1-3.4 °C). The moderate warming produced a mean rate of mass loss in sea-level equivalent of only around 0.4 m per kyr, which means the long duration of MIS-11 interglacial conditions around Greenland was a necessary condition for the ice sheet to disappear almost completely.

  8. Minimally Invasive Surgery (MIS) Approaches to Thoracolumbar Trauma.

    Science.gov (United States)

    Kaye, Ian David; Passias, Peter

    2018-03-01

    Minimally invasive surgical (MIS) techniques offer promising improvements in the management of thoracolumbar trauma. Recent advances in MIS techniques and instrumentation for degenerative conditions have heralded a growing interest in employing these techniques for thoracolumbar trauma. Specifically, surgeons have applied these techniques to help manage flexion- and extension-distraction injuries, neurologically intact burst fractures, and cases of damage control. Minimally invasive surgical techniques offer a means to decrease blood loss, shorten operative time, reduce infection risk, and shorten hospital stays. Herein, we review thoracolumbar minimally invasive surgery with an emphasis on thoracolumbar trauma classification, minimally invasive spinal stabilization, surgical indications, patient outcomes, technical considerations, and potential complications.

  9. Mis tunne on elada rikutud kuulmisega?

    Index Scriptorium Estoniae

    2005-01-01

    Euroopa Tööohutuse ja Töötervishoiu Agentuur kutsub internetilehekülel http://ew2005.osha.eu.int/ kuulama erinevaid helifaile teada saamiseks, mis tunne on võiks olla, kui inimene kaotab oma kuulmise. Euroopas peetakse 24.-28. okt. müravastast nädalat

  10. Hokimatsh, mis muutis maailma / Paul Goble

    Index Scriptorium Estoniae

    Goble, Paul Alan, 1949-

    2005-01-01

    Mart Laari koostatud PÖFFi filmiprogrammist "külma sõja" ajal läänes loodud filmidest, mis kõige teravamalt näitavad nõukogude süsteemi inimvaenulikkust - "Kõige keelatumad". Teemaga seoses lähemalt Gavin O'Connori filmist "Ime" ("Miracle") : Ameerika Ühendriigid 2004

  11. Investigation of MIS-sensor sensitivity to vapor of unsymmetrical dimethylgydrazine in air

    Science.gov (United States)

    Filipchuk, D. V.; Litvinov, A. V.; Etrekova, M. O.; Nozdrya, D. A.

    2018-01-01

    The sensitivity of MIS-sensor to the products of thermal decomposition of unsymmetrical dimethylhydrazine was investigated. It is shown that MIS sensor is able to detect the concentrations of the test substance by the means of the certain products of its thermal decomposition (ammonia and nitric dioxide).

  12. Three-year postoperative outcomes between MIS and conventional TLIF in1-segment lumbar disc herniation.

    Science.gov (United States)

    Lv, You; Chen, Jingyang; Chen, Jinchuan; Wu, Yuling; Chen, Xiangyang; Liu, Yi; Chu, Zhaoming; Sheng, Luxin; Qin, Rujie; Chen, Ming

    2017-06-01

    The aim of this study is to assess the long-term clinical and radiological outcomes between minimally invasive (MIS) and conventional transforaminal lumbar interbody fusion (TLIF) in treating one-segment lumbar disc herniation (LDH). One-hundred and six patients treated by MIS-TLIF (50 cases) or conventional TLIF (56 cases) were included. Perioperative results were evaluated. Clinical outcomes were compared preoperatively and postoperatively. Radiologic parameters were based on a comparison of preoperative and three-year postoperative lumbar lordosis, segmental lordosis, sacral slope, the cross-sectional area of the paraspinal muscle and fusion rates. MIS TILF had significantly less blood, shorter operation time, mean return to work time and lower intramuscular pressure compared with the conventional group during the operation. VAS scores for lower back pain and ODI in MIS-TLIF were significantly decreased. The mean cross-sectional area of the paraspinal muscle was significantly decreased after surgery in the conventional TLIF group and no significant intragroup differences were established in the MIS-TLIF group. No significant differences were found in fusion rate, lumbar lordosis, segmental lordosis and sacral slope. Both MIS and conventional TLIF were beneficial for patients with LDH. However, MIS-TLIF manifests a great improvement in perioperative outcomes, low back pain, disability and preventing paraspinal muscle atrophy during the follow-up period observation.

  13. High Performance Enhancement-Mode AlGaN/GaN MIS-HEMT with Selective Fluorine Treatment

    Directory of Open Access Journals (Sweden)

    Chao Yang

    2015-01-01

    Full Text Available A novel enhancement-mode (E-mode Metal-Insulator-Semiconductor- (MIS- HEMT with selective fluorine ion (F− treatment is proposed and its mechanism is investigated. The HEMT features the Selective F− treatment both in the AlGaN channel region and in the thick passivation layer between the gate and drain (SFCP-MIS-HEMT. First, the F− in the passivation layer not only extends the depletion region and thus enhances the average electric field (E-field between the gate and drain by the assisted depletion effect but also reduces the E-field peak at the gate end, leading to a higher breakdown voltage (BV. Second, in the AlGaN channel region, the F− region realizes the E-mode and the region without F− maintains a high drain current (ID. Third, MIS structure suppresses the gate leakage current, increasing the gate swing voltage and the BV. Compared with a MIS-HEMT with F− treatment in whole channel (FC-MIS-HEMT, SFCP-MIS-HEMT increases the BV by 46% and the saturation drain current (ID,sat by 28%.

  14. Periodontal disease bacteria specific to tonsil in IgA nephropathy patients predicts the remission by the treatment.

    Directory of Open Access Journals (Sweden)

    Yasuyuki Nagasawa

    Full Text Available BACKGROUND: Immunoglobulin (IgA nephropathy (IgAN is the most common form of primary glomerulonephritis in the world. Some bacteria were reported to be the candidate of the antigen or the pathogenesis of IgAN, but systematic analysis of bacterial flora in tonsil with IgAN has not been reported. Moreover, these bacteria specific to IgAN might be candidate for the indicator which can predict the remission of IgAN treated by the combination of tonsillectomy and steroid pulse. METHODS AND FINDINGS: We made a comprehensive analysis of tonsil flora in 68 IgAN patients and 28 control patients using Denaturing gradient gel electrophoresis methods. We also analyzed the relationship between several bacteria specific to the IgAN and the prognosis of the IgAN. Treponema sp. were identified in 24% IgAN patients, while in 7% control patients (P = 0.062. Haemophilus segnis were detected in 53% IgAN patients, while in 25% control patients (P = 0.012. Campylobacter rectus were identified in 49% IgAN patients, while in 14% control patients (P = 0.002. Multiple Cox proportional-hazards model revealed that Treponema sp. or Campylobactor rectus are significant for the remission of proteinuria (Hazard ratio 2.35, p = 0.019. There was significant difference in remission rates between IgAN patients with Treponema sp. and those without the bacterium (p = 0.046, and in remission rates between IgAN patients with Campylobacter rectus and those without the bacterium (p = 0.037 by Kaplan-Meier analysis. Those bacteria are well known to be related with the periodontal disease. Periodontal bacteria has known to cause immune reaction and many diseases, and also might cause IgA nephropathy. CONCLUSION: This insight into IgAN might be useful for diagnosis of the IgAN patients and the decision of treatment of IgAN.

  15. Periodontal disease bacteria specific to tonsil in IgA nephropathy patients predicts the remission by the treatment.

    Science.gov (United States)

    Nagasawa, Yasuyuki; Iio, Kenichiro; Fukuda, Shinji; Date, Yasuhiro; Iwatani, Hirotsugu; Yamamoto, Ryohei; Horii, Arata; Inohara, Hidenori; Imai, Enyu; Nakanishi, Takeshi; Ohno, Hiroshi; Rakugi, Hiromi; Isaka, Yoshitaka

    2014-01-01

    Immunoglobulin (Ig)A nephropathy (IgAN) is the most common form of primary glomerulonephritis in the world. Some bacteria were reported to be the candidate of the antigen or the pathogenesis of IgAN, but systematic analysis of bacterial flora in tonsil with IgAN has not been reported. Moreover, these bacteria specific to IgAN might be candidate for the indicator which can predict the remission of IgAN treated by the combination of tonsillectomy and steroid pulse. We made a comprehensive analysis of tonsil flora in 68 IgAN patients and 28 control patients using Denaturing gradient gel electrophoresis methods. We also analyzed the relationship between several bacteria specific to the IgAN and the prognosis of the IgAN. Treponema sp. were identified in 24% IgAN patients, while in 7% control patients (P = 0.062). Haemophilus segnis were detected in 53% IgAN patients, while in 25% control patients (P = 0.012). Campylobacter rectus were identified in 49% IgAN patients, while in 14% control patients (P = 0.002). Multiple Cox proportional-hazards model revealed that Treponema sp. or Campylobactor rectus are significant for the remission of proteinuria (Hazard ratio 2.35, p = 0.019). There was significant difference in remission rates between IgAN patients with Treponema sp. and those without the bacterium (p = 0.046), and in remission rates between IgAN patients with Campylobacter rectus and those without the bacterium (p = 0.037) by Kaplan-Meier analysis. Those bacteria are well known to be related with the periodontal disease. Periodontal bacteria has known to cause immune reaction and many diseases, and also might cause IgA nephropathy. This insight into IgAN might be useful for diagnosis of the IgAN patients and the decision of treatment of IgAN.

  16. Mis-diode as a low-energy X- and γ-ray spectrometer

    International Nuclear Information System (INIS)

    Konova, A.

    1980-01-01

    Considered are main peculiarities of apparata called MIS-diods having metal-thin isolating semiconductor structure and used as detectors of low-energy gamma and X-ray radiation. Discussed are advantages of tunnel MIS-diods based on non-primitive carriers. Presented are results of experimental measurements carried out using system of metal-silion oxide-silicon with the oxide layer width of 10-25 A (silicon with acceptor concentration of 10 19 m -3 ). Data presented show that MIS-diods can be considered as diods with p-n - transition in which n + - region is an inversion layer near the semiconductor surface, and further a leant region is situated. When voltage is applied only the depth of the leant region changes. In case of high quality diods the leakage currents are very small. Results of the investigation performed show that MIS-diods with oxide film wiolth of 10-22 A (the film covering p-silicon with high specific resistance) can be used as spectrometers of low-energy photons having particularly high energetic solution at room temperature. An advantage of new diods is the reverse current significantly lower in comparison with that of usual detectors with the Schottky barrier

  17. DESIGNING UNDERGRADUATE CURRICULUM FOR MANAGEMENT INFORMATION SYSTEMS (MIS EDUCATION: A COMPARISON OF THE MIS PROGRAMS OF TURKISH UNIVERSITIES WITH THOSE OF GLOBAL UNIVERSITIES

    Directory of Open Access Journals (Sweden)

    Eyüp AKÇETİN

    2017-05-01

    Full Text Available Competition in the global environment takes place among multinational corporations, which is directly linked to human resources and the quality of training and education they have. The competitive advantage of the businesses is associated with the excellence of human resources, which is measured by the education quality of the employees. Information systems have become an essential requirement for the businesses of today’s digital age. Therefore, with this study, curricula of 90 universities’ Management Information Systems (MIS Undergraduate Programs, 57 of which are foreign and 33 are Turkish, were compared. The study methods include data mining approaches namely random clustering and making a text mining analysis. As the number and importance of the MIS programs are rapidly increasing, it is aimed with these approaches to contribute developing a world-class curriculum model to improve the quality of education of them. On that ground, the main purpose of this study is creating a framework that defines a world-class MIS curriculum model by presenting the current situation in Turkey.

  18. Designing Undergraduate Curriculum for Management Information Systems (MIS Education: A Comparison of the MIS Programs of Turkish Universities with those of Global Universities

    Directory of Open Access Journals (Sweden)

    Eyüp AKÇETİN

    2017-05-01

    Full Text Available Competition in the global environment takes place among multinational corporations, which is directly linked to human resources and the quality of training and education they have. The competitive advantage of the businesses is associated with the excellence of human resources, which is measured by the education quality of the employees. Information systems have become an essential requirement for the businesses of today’s digital age. Therefore, with this study, curricula of 90 universities’ Management Information Systems (MIS Undergraduate Programs, 57 of which are foreign and 33 are Turkish, were compared. The study methods include data mining approaches namely random clustering and making a text mining analysis. As the number and importance of the MIS programs are rapidly increasing, it is aimed with these approaches to contribute developing a world-class curriculum model to improve the quality of education of them. On that ground, the main purpose of this study is creating a framework that defines a world-class MIS curriculum model by presenting the current situation in Turkey.

  19. Pharyngeal mis-sequencing in dysphagia: characteristics, rehabilitative response, and etiological speculation.

    Science.gov (United States)

    Huckabee, Maggie-Lee; Lamvik, Kristin; Jones, Richard

    2014-08-15

    Clinical data are submitted as documentation of a pathophysiologic feature of dysphagia termed pharyngeal mis-sequencing and to encourage clinicians and researchers to adopt more critical approaches to diagnosis and treatment planning. Recent clinical experience has identified a cohort of patients who present with an atypical dysphagia not specifically described in the literature: mis-sequenced constriction of the pharynx when swallowing. As a result, they are unable to coordinate streamlined bolus transfer from the pharynx into the esophagus. This mis-sequencing contributes to nasal redirection, aspiration, and, for some, the inability to safely tolerate an oral diet. Sixteen patients (8 females, 8 males), with a mean age of 44 years (range=25-78), had an average time post-onset of 23 months (range=2-72) at initiation of intensive rehabilitation. A 3-channel manometric catheter was used to measure pharyngeal pressure. The average peak-to-peak latency between nadir pressures at sensor-1 and sensor-2 was 15 ms (95% CI, -2 to 33 ms), compared to normative mean latency of 239 ms (95% CI, 215 to 263 ms). Rehabilitative responses are summarized, along with a single detailed case report. It is unclear from these data if pharyngeal mis-sequencing is (i) a pathological feature of impaired motor planning from brainstem damage or (ii) a maladaptive compensation developed in response to chronic dysphagia. Future investigation is needed to provide a full report of pharyngeal mis-sequencing, and the implications on our understanding of underlying neural control of swallowing. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. Pre-mRNA mis-splicing of sarcomeric genes in heart failure.

    Science.gov (United States)

    Zhu, Chaoqun; Chen, Zhilong; Guo, Wei

    2017-08-01

    Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eukaryotic organisms. Alternative splicing is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mechanisms with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in heart failure has also been discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Mullerian Inhibiting Substance (MIS) Augments IFN-gamma Mediated Inhibition of Breast Cancer Cell Growth

    National Research Council Canada - National Science Library

    Gupta, Vandana

    2004-01-01

    Mullerian Inhibiting Substance (MIS), a member of the TGFB family regulates growth, differentiation, and apoptosis in many cell types In the male embryo, MIS causes regression of the Mullerian duct...

  2. Integrated geochronology of Acheulian sites from the southern Latium (central Italy): Insights on human-environment interaction and the technological innovations during the MIS 11-MIS 10 period

    Science.gov (United States)

    Pereira, Alison; Nomade, Sébastien; Moncel, Marie-Hélène; Voinchet, Pierre; Bahain, Jean-Jacques; Biddittu, Italo; Falguères, Christophe; Giaccio, Biagio; Manzi, Giorgio; Parenti, Fabio; Scardia, Giancarlo; Scao, Vincent; Sottili, Gianluca; Vietti, Amina

    2018-05-01

    We have explored the multimethod approach combining 40Ar/39Ar on single crystal, ESR on bleached quartz, and ESR/U-series on teeth to improve the age of four neighbours "Acheulian" sites of the Frosinone Province (Latium, Italy): Fontana Ranuccio, Cava Pompi (Pofi), Isoletta, and Lademagne. Ages obtained by the three methods are in mutual agreement and confirm the potential of dating with confidence Middle Pleistocene sites of Italy using these methods. At Fontana Ranuccio, the 40Ar/39Ar age (408 ± 10 ka, full external error at 2σ) obtained for the archaeological level (unit FR4) and geochemical analyses of glass shards performed on the Unit FR2a layer allow us to attribute the studied volcanic material to the Pozzolane Nere volcanic series, a well-known caldera-forming event originated from the Colli Albani volcanic district. These new data ascribe the Fontana Ranuccio site, as well as the eponym faunal unit, to the climatic optimum of Marine Isotope Stage (MIS) 11. Ages obtained for the Cava Pompi, Isoletta, and Lademagne sites cover a relatively short period of time between 408 ka and 375 ka, spanning MIS 11 climatic optimum to the MIS 11-10 transition. Analysis of small collections of lithic industries, bifacial tools, and small cores technologies from Isoletta, Lademagne, and the neighbour site of Ceprano-Campogrande shows common technical strategies for the period comprised between MIS 11 and MIS 9 (410-325 ka), such as the elaboration of flaked elephant bone industries found over the whole Latium region. However, some features found only in the Frosinone province area, like large-sized bifaces, suggest particular regional behaviours. The presence of one Levallois core in the oldest layer of Lademagne (i.e. > 405 ± 9 ka) suggests a punctual practice of this technology, also proposed as early as MIS 10/11 in the neighbour site of Guado San Nicola (Molise) in central Italy.

  3. Ecosystem change during MIS4 and early MIS 3: Evidence from Middle Stone Age sites in South Africa

    CSIR Research Space (South Africa)

    Hall, G

    2010-11-01

    Full Text Available Several Middle Stone Age (MSA) site in southern Africa present evidence of environmental changes during Marine Isotope Stages (MIS) 4 and 3 between 70ka and 50ka. Of these, Sibudu Cave, KwaZulu-Natal, has yielded a detailed record of how globalscale...

  4. Differentiation of MIS 9 and MIS 11 in the continental record: vegetational, faunal, aminostratigraphic and sea-level evidence from coastal sites in Essex, UK

    Science.gov (United States)

    Roe, Helen M.; Coope, G. Russell; Devoy, Robert J. N.; Harrison, Colin J. O.; Penkman, Kirsty E. H.; Preece, Richard C.; Schreve, Danielle C.

    2009-11-01

    Multidisciplinary investigations of the vegetational, faunal and sea-level history inferred from the infills of buried channels on the coast of eastern Essex have a direct bearing on the differentiation of MIS 11 and MIS 9 in continental records. New data are presented from Cudmore Grove, an important site on Mersea Island that can be linked to the terrace sequence of the River Thames. The vegetational history has been reconstructed from a pollen sequence covering much of the interglacial represented. The temperate nature of the climate is apparent from a range of fossil groups, including plant remains, vertebrates (especially the rich herpetofauna), molluscs and beetles, which all have strong thermophilous components. The beetle data have been used to derive a Mutual Climatic Range reconstruction, suggesting that mean July temperatures were about 2 °C warmer than modern values for southeast England, whereas mean January temperatures may have been slightly colder. The sea-level history has been reconstructed from the molluscs, ostracods and especially the diatoms, which indicate that the marine transgression occurred considerably earlier in the interglacial cycle than at the neighbouring Hoxnian site at Clacton. There are a number of palynological similarities between the sequence at Cudmore Grove and Clacton, especially the presence of Abies and the occurrence of Azolla filiculoides megaspores. Moreover, both sites have yielded Palaeolithic archaeology, indeed the latter is the type site of the Clactonian (flake-and-core) industry. However, the sites can be differentiated on the basis of mammalian biostratigraphy, new aminostratigraphic data, as well as the differences in the sea-level history. The combined evidence suggests that the infill of the channel at Cudmore Grove accumulated during MIS 9, whereas the deposits at Clacton formed during MIS 11. The infill of a much later channel, yielding non-marine molluscs and vertebrates including Hippopotamus, appears

  5. Kümme kohtuotsust, mis on kõige enam mõjutanud Eesti majandust / Risto Vahimets

    Index Scriptorium Estoniae

    Vahimets, Risto, 1974-

    2007-01-01

    Sissejuhatus artikliseeriasse, mis annab ülevaate kümnest Eesti kohtuotsusest, mis on kõige enam mõjutanud Eesti majandust. Vt. samas: Luiga, Piret. Suurfirmad peavad maksma. // Director 2007 nr 1, lk. 47

  6. MIS approach for diverticula of the esophagus

    Science.gov (United States)

    2010-01-01

    Purpose Diverticula of the esophagus represent a rare pathological entity. Distinct classifications of the disease imply different surgical concepts. Surgery should be reserved for symptomatic patients only. Minimally invasive surgery (MIS) for treatment of esophageal diverticula encompasses rigid and flexible intraluminal endoscopy, thoracoscopy and laparoscopy. We here give an overview on the pathogenesis of esophageal diverticula, the minimally invasive surgical techniques for treatment and the recent literature. Additionally, we present our own experience with MIS for midthoracic diverticula. Methods We analyzed the cases of patients who underwent MIS for midthoracic diverticula with regard to preoperative symptoms, perioperative and follow-up data. Results Three patients (two female, one male, age 79, 78 and 59 years) received thoracoscopic surgery for midthoracic diverticula. All patients reported of dysphagia and regurgitation. In two patients pH-investigation showed pathological reflux but manometry was normal in all patients. Operating time was 205, 135 and 141 minutes. We performed intraoperative intraluminal endoscopy in all patients. There were no intraoperative complications and although no surgical complications occured postoperatively one patient developed pneumonia which advanced to sepsis and lethal multi organ failure. Upon follow-up the two patients did not have recurrent diverticula or a recurrence of previous symptoms. Conclusions Surgery for diverticular disease of the esophagus has been associated with high rates of morbidity and mortality. Despite the lethal non-surgical complication we encountered, with regard to recent publications minimally invasive apporaches to treat patients with symptomatic esophageal diverticula entail lower rates of complications with better long term results in comparison to open surgery. PMID:20952348

  7. Mis tuleb

    Index Scriptorium Estoniae

    2005-01-01

    Pärnu Uue Kunsti Muuseumis Uno Roosvaldi maalide ja graafika näitus "Mõttes Kihnus", Heino Lillepuu kollaazhide näitus "Kõik naised on inglid". Tartu Mänguasjamuuseumis jõuluehete näitus. Rahvusraamatukogu fuajees Andy Horneri näitus "Terra Borealis". Eesti Rahva Muuseumis näitus "Põhjamaine tunnetus", mis tutvustab Sleipneri stipendiumi saanud noorte kunstnike valiktöid. Iisaku muuseumis jõulupostkaartide näitus. Eesti Tarbekunsti- ja Disainimuuseumis näitus "Klaashelmed maailma rahvaste kultuuris" (suur osa helmeist ja helmetikandeist on Torben Sode kogust). Rottermanni soolalaos näitus "Kodu, kallis kodu". Viljandi muuseumis on väljas EKA nahakunsti osakonna tööd aastaist 1917-2004 "Mälu ja mäng", Eesti lapitööseltsi näitus, Viljandi maagümnaasiumi kunstistuudio näitus "Jõulusokk". Eesti Meremuuseumis näitus"Klaas, fajanss ja portselan uppunud laevadelt"

  8. Mis on parem - Zaporozhets või Mercedes? / Andres Langemets

    Index Scriptorium Estoniae

    Langemets, Andres, 1948-

    2007-01-01

    Vastukaja Mikko Lagerspetzi artiklile 5. dets. Postimehes, mis oli omakorda vastukaja Jaak Aaviksoo artiklile 19. nov. Postimehes. Sotsioloogiast, sotsiaalteadlastest ja sotsioloogilistest küsitlustest

  9. Mullerian Inhibiting Substances (MIS) Augments IFN-gamma Mediated Inhibition of Breast Cancer Cell Growth

    National Research Council Canada - National Science Library

    Gupta, Vandana

    2006-01-01

    MIS is a member of the TGF family. The purpose of this study is to test the hypothesis that MIS and IFN-gamma might be more effective in the inhibition of breast cancer cell growth than either agent alone...

  10. Recruitment of Hispanic Students into MIS Curricula

    Science.gov (United States)

    McHaney, Roger; Martin, Dawne

    2007-01-01

    This paper provides several suggestions Hispanic student recruitment and retention in MIS or other business curricula. Cultural considerations like allocentrism and familialism are discussed along with the situation at K-State. It is believed that the recruitment and retention of Hispanic students can be influenced positively by considering…

  11. Sea level ~400 000 years ago (MIS 11: analogue for present and future sea-level?

    Directory of Open Access Journals (Sweden)

    D. Q. Bowen

    2010-01-01

    Full Text Available Comparison of the sea-level today with that of 400 000 years ago (MIS 11, when the Earth's orbital characteristics were similar may provide, under conditions of natural variability, indications of future sea-level during the present interglacial. Then, as now, orbital eccentricity was low and precession dampened. Evidence for MIS 11 sea-level occurs on uplifting coastlines where shorelines with geochronological ages have been preserved. The sea-level term and the uplift term may be separated with an "uplift correction" formula. This discovers the original sea-level at which the now uplifted shoreline was fashioned. Estimates are based on average uplift rates of the "last interglacial" sea-level (MIS 5.5 using a range of estimates for sea-level and age at that time at different locations. These, with varying secular tectonic regimes in different ocean basins, provide a band of estimates for the MIS 11 sea-level. They do not support the hypothesis of an MIS 11 sea-level at ~20 m, and instead show that it was closer to its present level.

  12. Mis on mee sees? / Liisa Puusepp

    Index Scriptorium Estoniae

    Puusepp, Liisa, 1980-

    2017-01-01

    Õietolmuanalüüsi kasutuselevõtust meetodina möödub tänavu 100 aastat. Õietolmuanalüüsiga saab kindlaks määrata, mis taimede õietolmuterad mees leiduvad ning korjeala. Tallinna Ülikooli ökoloogia keskuses rakendatakse õietolmuanalüüsi eelkõige mineviku taimkatte struktuuri, maakasutuse muutuse ja maastiku avatuse rekonstrueerimiseks, lisaks tehakse ka mee õietolmuanalüüsi

  13. Toward optimal implementation of cancer prevention and control programs in public health: a study protocol on mis-implementation.

    Science.gov (United States)

    Padek, Margaret; Allen, Peg; Erwin, Paul C; Franco, Melissa; Hammond, Ross A; Heuberger, Benjamin; Kasman, Matt; Luke, Doug A; Mazzucca, Stephanie; Moreland-Russell, Sarah; Brownson, Ross C

    2018-03-23

    Much of the cancer burden in the USA is preventable, through application of existing knowledge. State-level funders and public health practitioners are in ideal positions to affect programs and policies related to cancer control. Mis-implementation refers to ending effective programs and policies prematurely or continuing ineffective ones. Greater attention to mis-implementation should lead to use of effective interventions and more efficient expenditure of resources, which in the long term, will lead to more positive cancer outcomes. This is a three-phase study that takes a comprehensive approach, leading to the elucidation of tactics for addressing mis-implementation. Phase 1: We assess the extent to which mis-implementation is occurring among state cancer control programs in public health. This initial phase will involve a survey of 800 practitioners representing all states. The programs represented will span the full continuum of cancer control, from primary prevention to survivorship. Phase 2: Using data from phase 1 to identify organizations in which mis-implementation is particularly high or low, the team will conduct eight comparative case studies to get a richer understanding of mis-implementation and to understand contextual differences. These case studies will highlight lessons learned about mis-implementation and identify hypothesized drivers. Phase 3: Agent-based modeling will be used to identify dynamic interactions between individual capacity, organizational capacity, use of evidence, funding, and external factors driving mis-implementation. The team will then translate and disseminate findings from phases 1 to 3 to practitioners and practice-related stakeholders to support the reduction of mis-implementation. This study is innovative and significant because it will (1) be the first to refine and further develop reliable and valid measures of mis-implementation of public health programs; (2) bring together a strong, transdisciplinary team with

  14. FATCA - mis see on? / Steve Austwick ; intervjueerinud Joel Zernask

    Index Scriptorium Estoniae

    Austwick, Steve

    2012-01-01

    Ameerika Ühendriikide seaduseelnõust, mis mõjutab enamikku finantsteenuseid pakkuvaid ettevõtteid üle maailma, sealhulgas ka Balti riikides. Lisatud FATCA ajakava. FATCA = Foreign Account Tax Compliance Act

  15. A data driven method to measure electron charge mis-identification rate

    CERN Document Server

    Bakhshiansohi, Hamed

    2009-01-01

    Electron charge mis-measurement is an important challenge in analyses which depend on the charge of electron. To estimate the probability of {\\it electron charge mis-measurement} a data driven method is introduced and a good agreement with MC based methods is achieved.\\\\ The third moment of $\\phi$ distribution of hits in electron SuperCluster is studied. The correlation between this variable and the electron charge is also investigated. Using this `new' variable and some other variables the electron charge measurement is improved by two different approaches.

  16. Victor Hugo, ‚Les Misérables´ (1862)

    OpenAIRE

    Krauss, Henning

    1999-01-01

    Victor Hugo, ‚Les Misérables´ (1862). - In: 19. Jahrhundert - Roman / Friedrich Wolfzettel (Hrsg.). - Tübingen : Stauffenburg-Verl., 1999. - S. 185-218. - (Stauffenburg Interpretation : Französische Literatur)

  17. Comparative Study of the Difference of Perioperative Complication and Radiologic Results: MIS-DLIF (Minimally Invasive Direct Lateral Lumbar Interbody Fusion) Versus MIS-OLIF (Minimally Invasive Oblique Lateral Lumbar Interbody Fusion).

    Science.gov (United States)

    Jin, Jie; Ryu, Kyeong-Sik; Hur, Jung-Woo; Seong, Ji-Hoon; Kim, Jin-Sung; Cho, Hyun-Jin

    2018-02-01

    Retrospective observatory analysis. The purpose of this study was to compare the incidence of perioperative complication, difference of cage location, and sagittal alignment between minimally invasive oblique lateral lumbar interbody fusion (MIS-OLIF) and MIS-direct lateral lumbar interbody fusion (DLIF) in the cases of single-level surgery at L4-L5. MIS-DLIF using tubular retractor has been used for the treatment of lumbar degenerative diseases; however, blunt transpsoas dissection poses a risk of injury to the lumbar plexus. As an alternative, MIS-OLIF uses a window between the prevertebral venous structures and psoas muscle. A total of 43 consecutive patients who underwent MIS-DLIF or MIS-OLIF for various L4/L5 level pathologies between November 2011 and April 2014 by a single surgeon were retrospectively reviewed. A complication classification based on the relation to surgical procedure and effect duration was used. Perioperative complications until 3-month postoperatively were reviewed for the patients. Radiologic results including the cage location and sagittal alignment were also assessed with plain radiography. There were no significant statistical differences in perioperative parameters and early clinical outcome between 2 groups. Overall, there were 13 (59.1%) approach-related complications in the DLIF group and 3 (14.3%) in the OLIF group. In the DLIF group, 3 (45.6%) were classified as persistent, however, there was no persistent complication in the OLIF group. In the OLIF group, cage is located mostly in the middle 1/3 of vertebral body, significantly increasing posterior disk space height and foraminal height compared with the DLIF group. Global and segmental lumbar lordosis was greater in the DLIF group due to anterior cage position without statistical significance. In our report of L4/L5 level diseases, the OLIF technique may decrease approach-related perioperative morbidities by eliminating the risk of unwanted muscle and nerve manipulations. Using

  18. Lawrence Livermore National Laboratory (LLNL) Oxide Material Representation in the Material Identification and Surveillance (MIS) Program, Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Riley, D C; Dodson, K

    2004-06-30

    The Materials Identification and Surveillance (MIS) program was established within the 94-1 R&D Program to confirm the suitability of plutonium-bearing materials for stabilization, packaging, and long-term storage under DOE-STD-3013-2000. Oxide materials from different sites were chemically and physically characterized. The adequacy of the stabilization process parameters of temperature and duration at temperature (950 C and 2 hours) for eliminating chemical reactivity and reducing the moisture content to less than 0.5 weight percent were validated. Studies also include surveillance monitoring to determine the behavior of the oxides and packaging materials under storage conditions. Materials selected for this program were assumed to be representative of the overall inventory for DOE sites. The Quality Assurance section of the DOE-STD-3013-2000 required that each site be responsible for assuring that oxides packaged according to this standard are represented by items in the MIS characterization program. The purpose of this document is to define the path for determining if an individual item is ''represented'' in the MIS Program and to show that oxides being packaged at Lawrence Livermore National Laboratory (LLNL) are considered represented in the MIS program. The methodology outlined in the MIS Representation Document (LA-14016-MS) for demonstrating representation requires concurrence of the MIS working Group (MIS-WG). The signature page on this document provides for the MIS-WG concurrence.

  19. Vale, mis ei taha surra / Urmas Kiil

    Index Scriptorium Estoniae

    Kiil, Urmas

    2005-01-01

    Juuditar Hadassa Ben-Itto raamatu "Vale, mis ei taha surra" (The Lie That Wouldn't Die: the Protocols of the Elders of Zion) sünniloost. Autor, kes oli Iisraelis kõrge kohtunik, loobus oma karjäärist, et tuua avalikkuse ette tõde XX sajandil palju surma külvanud plagiaadist "Siioni tarkade protokollid"

  20. Mis siis juhtus Andres Lapeteusega? / Õie Orav

    Index Scriptorium Estoniae

    Orav, Õie

    2011-01-01

    Režissöör Grigori Kromanovi filmist "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1965). Osades: Einari Koppel, Ita Ever, Heino Mandri, Kaljo Kiisk, Uno Loit, Ada Lundver jt. Lühidalt filmi kohta ilmunud arvustustest. Filmi näeb ETV2-s sarjas "Unustatud filmid"

  1. Mis ikkagi teeb Eestist Uganda? / Marja-Liisa Alop

    Index Scriptorium Estoniae

    Alop, Marja-Liisa

    2006-01-01

    Eesti üliõpilaskondade liidu juhatuse aseesimees M.-L. Alop kirjutab vastuse M. Heidmetsa artiklile 6. jaan. Eesti Päevalehes "Eestis nagu Ugandas", kus tõstatati Eestis üldise õppemaksu kehtestamise vajadus, mis vähendab vähem kindlustatute võimalusi kõrgharidust omandada

  2. MIS hot electron devices for enhancement of surface reactivity by hot electrons

    DEFF Research Database (Denmark)

    Thomsen, Lasse Bjørchmar

    A Metal-Insulator-Semiconductor (MIS) based device is developed for investigation of hot electron enhanced chemistry. A model of the device is presented explaining the key concepts of the functionality and the character- istics. The MIS hot electron emitter is fabricated using cleanroom technology...... and the process sequence is described. An Ultra High Vacuum (UHV) setup is modified to facilitate experiments with electron emission from the MIS hot electron emitters and hot electron chemistry. Simulations show the importance of keeping tunnel barrier roughness to an absolute minimum. The tunnel oxide...... to be an important energy loss center for the electrons tunneling through the oxide lowering the emission e±ciency of a factor of 10 for a 1 nm Ti layer thickness. Electron emission is observed under ambient pressure conditions and in up to 2 bars of Ar. 2 bar Ar decrease the emission current by an order...

  3. Higher HOMA-IR index and correlated factors of insulin resistance in patients with IgA nephropathy.

    Science.gov (United States)

    Yang, Yue; Wei, Ri-Bao; Wang, Yuan-da; Zhang, Xue-Guang; Rong, Na; Tang, Li; Chen, Xiang-Mei

    2012-11-01

    To investigate the index of homeostasis model of insulin resistance (HOMA-IR) in IgA nephropathy (IgAN) patients, and to explore the possible correlated factors contributing to insulin resistance (IR) within these patients. There were 255 IgAN patients and 45 membranous nephropathy (MN) patients in our database. We identified 89 IgAN subjects and 21 MN subjects without diabetes and undergoing glucocorticoid therapy for at least 6 months. Data regarding physical examination, blood chemistry and renal pathology were collected from 89 IgAN subjects and 21 MN subjects. Then 62 IgAN patients and 19 MN patients with chronic kidney disease (CKD) Stage 1 - 2 were selected for the comparison of HOMA-IR index, 89 IgAN patients were selected for multiple regression analysis to test for correlated factors of HOMA-IR index with IgAN patients. Comparison between IgAN and MN show that HOMA-IR index was significantly higher in IgAN patients with CKD Stage 1 - 2. After logarithmic transformation with urine protein (UPr), Ln(UPr) (b = 0.186, p = 0.008), eGFR (b = -0.005, p = 0.014), > 50% of glomeruli with mesangial hypercellularity (b = 0.285, p = 0.027) and body mass index (BMI) (b = 0.039, p = 0.008) were correlated factors of HOMA-IR index in the multiple regression analysis. IgAN patients had higher HOMA-IR index compared with MN in the stages of CKD 1 - 2. For IgAN patients, more UPr, lower eGFR, > 50% of glomeruli with mesangial hypercellularity and higher BMI were correlated with IR.

  4. The Graduate MIS Security Course: Objectives and Challenges

    Science.gov (United States)

    Jensen, Bradley K.; Guynes, Carl S.; Nyaboga, Andrew

    2009-01-01

    Given the magnitude of real and potential losses, both private and public employers increasingly expect graduates of management information systems (MIS) programs to understand information security concepts. The infrastructure requirements for the course includes setting up a secure laboratory environment to accommodate the development of viruses…

  5. Al-Qaiada's (Mis)Adventures in the Horn of Africa

    National Research Council Canada - National Science Library

    2007-01-01

    .... Its private deliberations during this period are revealed by a trove of documents captured in the course of operations supporting the Global War on Terror and maintained in the Department of Defense's Harmony Database. Al-Qaida's (Mis...

  6. MILREM extends THeMIS mission set / Huw Williams

    Index Scriptorium Estoniae

    Williams, Huw

    2016-01-01

    Eesti kaitsetehnika ettevõte MILREM OÜ täiendab oma relvasüsteemi THeMIS ja teeb selleks koostööd mitmete firmadega. Tulevikus soovitakse lisaks Eesti kaitseväele teha koostööd ka Läti kaitseväega ja kasutada sõjatehnikat sealsetel õppustel

  7. SST and ice sheet impacts on the MIS-13 climate

    Energy Technology Data Exchange (ETDEWEB)

    Muri, Helene; Berger, Andre; Yin, Qiuzhen; Sundaram, Suchithra [Universite catholique de Louvain, Georges Lemaitre Centre for Earth and Climate Research (TECLIM), Earth and Life Institute (ELI), Louvain la Neuve (Belgium); Voldoire, Aurore; Melia, David Salas Y. [CNRM-GAME Meteo-France/CNRS, Toulouse Cedex (France)

    2012-10-15

    As a first qualitative assessment tool, LOVECLIM has been used to investigate the interactions between insolation, ice sheets and the East Asian Monsoon at the Marine Isotopic Stage 13 (MIS-13) in work by Yin et al. (Clim Past 4:79-90, 2008, Clim Past 5:229-243, 2009). The results are in need of validation with a more sophisticated model, which is done in this work with the ARPEGE atmospheric general circulation model. As in the Earth system Model of Intermediate Complexity, LOVECLIM, ARPEGE shows that the northern hemispheric high insolation in summer leads to strong MIS-13 monsoon precipitation. Data from the Chinese Loess Plateau indicate that MIS-13 was locally a warm and humid period (Guo et al. in Clim Past 5:21-31, 2009; Yin and Guo in Chin Sci Bull 51(2):213-220, 2006). This is confirmed by these General Circulation Model (GCM) results, where the MIS-13 climate is found to be hotter and more humid both in the presence and absence of any added ice sheets. LOVECLIM found that the combined effects of the ice sheets and their accompanying SSTs contribute to more precipitation in eastern China, whilst in ARPEGE the impact is significant in northeastern China. Nonetheless the results of ARPEGE confirm the counter-intuitive results of LOVECLIM where ice sheets contribute to enhance monsoon precipitation. This happens through a topography induced wave propagating through Eurasia with an ascending branch over northeastern China. A feature which is also seen in LOVECLIM. The SST forcing in ARPEGE results in a strong zonal temperature gradient between the North Atlantic and east Eurasia, which in turn triggers an atmospheric gravity wave. This wave induces a blocking Okhotskian high, preventing the northwards penetration of the Meiyu monsoon front. The synergism between the ice sheets and SST is found through the factor separation method, yielding an increase in the Meiyu precipitation, though a reduction of the Changma precipitation. The synergism between the ice

  8. MIS 5e relative sea-level changes in the Mediterranean Sea: Contribution of isostatic disequilibrium

    Science.gov (United States)

    Stocchi, Paolo; Vacchi, Matteo; Lorscheid, Thomas; de Boer, Bas; Simms, Alexander R.; van de Wal, Roderik S. W.; Vermeersen, Bert L. A.; Pappalardo, Marta; Rovere, Alessio

    2018-04-01

    Sea-level indicators dated to the Last Interglacial, or Marine Isotope Stage (MIS) 5e, have a twofold value. First, they can be used to constrain the melting of Greenland and Antarctic Ice Sheets in response to global warming scenarios. Second, they can be used to calculate the vertical crustal rates at active margins. For both applications, the contribution of glacio- and hydro-isostatic adjustment (GIA) to vertical displacement of sea-level indicators must be calculated. In this paper, we re-assess MIS 5e sea-level indicators at 11 Mediterranean sites that have been generally considered tectonically stable or affected by mild tectonics. These are found within a range of elevations of 2-10 m above modern mean sea level. Four sites are characterized by two separate sea-level stands, which suggest a two-step sea-level highstand during MIS 5e. Comparing field data with numerical modeling we show that (i) GIA is an important contributor to the spatial and temporal variability of the sea-level highstand during MIS 5e, (ii) the isostatic imbalance from the melting of the MIS 6 ice sheet can produce a >2.0 m sea-level highstand, and (iii) a two-step melting phase for the Greenland and Antarctic Ice Sheets reduces the differences between observations and predictions. Our results show that assumptions of tectonic stability on the basis of the MIS 5e records carry intrinsically large uncertainties, stemming either from uncertainties in field data and GIA models. The latter are propagated to either Holocene or Pleistocene sea-level reconstructions if tectonic rates are considered linear through time.

  9. Vegetation dynamics of the Guatemalan lowlands from MIS7 to MIS5: Evidence from Lake Petén-Itzá

    Science.gov (United States)

    Cruz-Silva, E.; Correa-Metrio, A.; Bush, M. B.

    2013-05-01

    Reconstructing vegetation patterns of past warm climatic stages is critical for understanding modern processes that affect diversity and climate. Tropical lowlands are of special interest because of the high biodiversity they foster and the risks they face under a scenario of rapid climate change. With a basal age of more that 191,000 years, core PI-1 from Lake Petén-Itzá, Guatemalan lowlands, offer an exceptional opportunity to investigate the dynamics of the vegetation of the area during climatic stages that might be analogous to today. Pollen analysis of the lower part of this sedimentary record shows a sequence of five different climatic stages of alternating warm and cold conditions. According to our interpretation, tropical forests extended in the area during MIS7 and MIS5, with the former characterized by drier conditions than the latter. Apparently forest dynamics closely followed global climatic changes that were recorded in the Antarctic and the Marine Stack records. Our results confirm that vegetation of the Peninsula, although highly resilient, has been very sensitive to global climatic changes.

  10. Investigation of the sensitivity of MIS-sensor to thermal decomposition products of cables insulation

    Science.gov (United States)

    Filipchuk, D. V.; Litvinov, A. V.; Etrekova, M. O.; Nozdrya, D. A.

    2017-12-01

    Sensitivity of the MIS-sensor to products of thermal decomposition of insulation and jacket of the most common types of cables is investigated. It is shown that hydrogen is evolved under heating the insulation to temperatures not exceeding 250 °C. Registration of the evolved hydrogen by the MIS-sensor can be used for detection of fires at an early stage.

  11. The effect of sociodemographic (mis)match between interviewers and respondents on unit and item nonresponse in Belgium.

    Science.gov (United States)

    Vercruyssen, Anina; Wuyts, Celine; Loosveldt, Geert

    2017-09-01

    Interviewer characteristics affect nonresponse and measurement errors in face-to-face surveys. Some studies have shown that mismatched sociodemographic characteristics - for example gender - affect people's behavior when interacting with an interviewer at the door and during the survey interview, resulting in more nonresponse. We investigate the effect of sociodemographic (mis)matching on nonresponse in two successive rounds of the European Social Survey in Belgium. As such, we replicate the analyses of the effect of (mis)matching gender and age on unit nonresponse on the one hand, and of gender, age and education level (mis)matching on item nonresponse on the other hand. Recurring effects of sociodemographic (mis)match are found for both unit and item nonresponse. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Foraminifera eco-biostratigraphy of the southern Evoikos outer shelf, central Aegean Sea, during MIS 5 to present

    Science.gov (United States)

    Drinia, Hara; Antonarakou, Assimina; Tsourou, Theodora; Kontakiotis, George; Psychogiou, Maria; Anastasakis, George

    2016-09-01

    The South Evoikos Basin is a marginal basin in the Aegean Sea which receives little terrigenous supply and its sedimentation is dominated by hemipelagic processes. Late Quaternary benthic and planktonic foraminifera from core PAG-155 are investigated in order to understand their response to the glacial-interglacial cycles in this region. The quantitative analysis of planktonic foraminifera, coupled with accelerator mass spectrometry (14C-AMS) radiocarbon date measurements, provide an integrated chrono-stratigraphic time framework over the last 90 ka (time interval between late Marine Isotopic Stages 5 and 1; MIS5-MIS1). The temporary appearance and disappearance as well as several abundance peaks in the quantitative distribution of selected climate-sensitive planktonic species allowed the identification of several eco-bioevents, useful to accurately mark the boundaries of the eco-biozones widely recognized in the Mediterranean records and used for large-scale correlations. The established bio-ecozonation scheme allows a detailed palaecological reconstruction for the late Pleistocene archive in the central Aegean, and furthermore provides a notable contribution for palaeoclimatic studies, facilitating intercorrelations between various oceanographic basins. The quantitative analyses of benthic foraminifera identify four distinct assemblages, namely Biofacies: Elphidium spp., Haynesina spp. Biofacies, characterized by neritic species, dominated during the transition from MIS 5 to MIS 4; Cassidulina laevigata/carinata Biofacies dominated till 42 ka (transgressive trend from MIS 4 to MIS 3); Bulimina gibba Biofacies dominated from 42 ka to 9.5 ka (extensive regression MIS 3,2 through lowstand and early transgression; beginning of MIS 1); Bulimina marginata, Uvigerina spp. Biofacies dominated from 9.5 ka to the present (late transgression through early highstand; MIS 1)., This study showed that the South Evoikos Basin which is characterized by its critical depths and

  13. Electrical properties of MIS devices on CdZnTe/HgCdTe

    Science.gov (United States)

    Lee, Tae-Seok; Jeoung, Y. T.; Kim, Hyun Kyu; Kim, Jae Mook; Song, Jinhan; Ann, S. Y.; Lee, Ji Y.; Kim, Young Hun; Kim, Sun-Ung; Park, Mann-Jang; Lee, S. D.; Suh, Sang-Hee

    1998-10-01

    In this paper, we report the capacitance-voltage (C-V) properties of metal-insulator-semiconductor (MIS) devices on CdTe/HgCdTe by the metalorganic chemical vapor deposition (MOCVD) and CdZnTe/HgCdTe by thermal evaporation. In MOCVD, CdTe layers are directly grown on HgCdTe using the metal organic sources of DMCd and DiPTe. HgCdTe layers are converted to n-type and the carrier concentration, ND is low 1015 cm-3 after Hg-vacancy annealing at 260 degrees Celsius. In thermal evaporation, CdZnTe passivation layers were deposited on HgCdTe surfaces after the surfaces were etched with 0.5 - 2.0% bromine in methanol solution. To investigate the electrical properties of the MIS devices, the C-V measurement is conducted at 80 K and 1 MHz. C-V curve of MIS devices on CdTe/HgCdTe by MOCVD has shown nearly flat band condition and large hysteresis, which is inferred to result from many defects in CdTe layer induced during Hg-vacancy annealing process. A negative flat band voltage (VFB approximately equals -2 V) and a small hysteresis have been observed for MIS devices on CdZnTe/HgCdTe by thermal evaporation. It is inferred that the negative flat band voltage results from residual Te4+ on the surface after etching with bromine in methanol solution.

  14. Excretion of complement proteins and its activation marker C5b-9 in IgA nephropathy in relation to renal function

    Directory of Open Access Journals (Sweden)

    Onda Kisara

    2011-11-01

    Full Text Available Abstract Background Glomerular damage in IgA nephropathy (IgAN is mediated by complement activation via the alternative and lectin pathways. Therefore, we focused on molecules stabilizing and regulating the alternative pathway C3 convertase in urine which might be associated with IgAN pathogenesis. Methods Membrane attack complex (MAC, properdin (P, factor H (fH and Complement receptor type 1 (CR1 were quantified in urine samples from 71 patients with IgAN and 72 healthy controls. Glomerular deposition of C5, fH and P was assessed using an immunofluorescence technique and correlated with histological severity of IgAN and clinical parameters. Fibrotic changes and glomerular sclerosis were evaluated in renal biopsy specimens. Results Immunofluorescence studies revealed glomerular depositions of C5, fH and P in patients with IgAN. Urinary MAC, fH and P levels in IgAN patients were significantly higher than those in healthy controls (p Conclusions Complement activation occurs in the urinary space in IgAN and the measurement of levels of MAC and fH in the urine could be a useful indicator of renal injury in patients with IgAN.

  15. ON CODE REFACTORING OF THE DIALOG SUBSYSTEM OF CDSS PLATFORM FOR THE OPEN-SOURCE MIS OPENMRS

    Directory of Open Access Journals (Sweden)

    A. V. Semenets

    2016-08-01

    The open-source MIS OpenMRS developer tools and software API are reviewed. The results of code refactoring of the dialog subsystem of the CDSS platform which is made as module for the open-source MIS OpenMRS are presented. The structure of information model of database of the CDSS dialog subsystem was updated according with MIS OpenMRS requirements. The Model-View-Controller (MVC based approach to the CDSS dialog subsystem architecture was re-implemented with Java programming language using Spring and Hibernate frameworks. The MIS OpenMRS Encounter portlet form for the CDSS dialog subsystem integration is developed as an extension. The administrative module of the CDSS platform is recreated. The data exchanging formats and methods for interaction of OpenMRS CDSS dialog subsystem module and DecisionTree GAE service are re-implemented with help of AJAX technology via jQuery library

  16. Relative sea-level changes and glacio-isostatic adjustment on the Magdalen Islands archipelago (Atlantic Canada) from MIS 5 to the late Holocene

    DEFF Research Database (Denmark)

    Rémillard, Audrey M.; St-Onge, Guillaume; Bernatchez, Pascal

    2017-01-01

    has risen at least 3 m during the last two millennia. Sediments dated to the MIS 5 and the interval between the late MIS 4 and the MIS 3 illustrate that the GIA following the LGM also occurred for the MIS 5 interglacial and the MIS 3 interstadial. Finally, recent GIA models are discussed in light...

  17. Genetic polymorphisms in HLA-DP and STAT4 are associated with IgA nephropathy in a Southwest Chinese population.

    Science.gov (United States)

    Yang, Bin; Zhang, Junlong; Liu, Xinle; Huang, Zhuochun; Su, Zhenzhen; Liao, Yun; Wang, Lanlan

    2018-01-23

    IgA nephropathy (IgAN) is the most common chronic glomerular disease worldwide. Genetic factors are thought to be crucial in the pathogenesis of IgAN. However, few data are available on the relationship between human leucocyte antigen (HLA) and signal transducer and activator of transcription 4 (STAT4) polymorphisms and IgAN susceptibility in the Chinese population. Therefore, we examined HLA-DP/DQ and STAT4 polymorphisms (rs3077, rs9277535, rs7453920 and rs7574865) in a total of 630 subjects including 140 IgAN and 490 healthy controls in Chinese. There were significant associations between IgAN patients and healthy controls in the allele frequency of rs3077, rs9277535 and rs7574865. In addition, the genotypes of rs3077, rs9277535 and rs7574865 were also significantly associated with IgAN under recessive models. Moreover, the haplotypes block AAG, AGG, GAG and GGA in the HLA gene significantly correlated with the risk of IgAN. This is the first study demonstrating the significant associations of SNP rs3077, rs9277535 and rs7574865 and the haplotypes in the HLA gene with the risk of IgAN in a Southwest Chinese population. This research provides a new insight into the significant relationship between HLA-DP and STAT4 polymorphisms and the susceptibility to IgAN.

  18. [Luuletused] / William Wordsworth ; tlk. Märt Väljataga

    Index Scriptorium Estoniae

    Wordsworth, William

    2004-01-01

    Sisu: Värsid, mis kirjutatud mõned miilid Tintern Abbeyst ülalpool... ; "Mõnd kirevahku kummalist..." ; "Käis vaikselt ojakalda peal..." ; "Kolm aastat sirguda ta võis..." ; "Mu hinge piiras unesulg..." ; "Kui mere taha viia ma..." ; Jugapuud. Saatesõna lk. 24. Orig.: Lines composed a few miles above Tintern Abbey... ; "Strange fits of passion have I known..." ; "She dwelt among the untrodden ways..." ; "Three years she grew..." ; "A slumber did my spirit seal..." ; "I traveled among unknown men..." ; Yew trees

  19. Hubungan Kadar Glukosa Darah Saat Masuk Rumah Sakit Dengan Lama Hari Rawat Pasien Sindrom Koroner Akut (SKA Di RSUP Dr. M. Djamil Padang

    Directory of Open Access Journals (Sweden)

    Rosi Oktarina

    2013-05-01

    Full Text Available AbstrakHiperglikemia masih menjadi topik penelitian yang sering dihubungkan dengan kejadian sindrom koroner akut (SKA di dunia, terutama hiperglikemia saat masuk rumah sakit. Hal ini didasari oleh beberapa pengaruh kadar glukosa darah yang tinggi terhadap sistem kardiovaskuler seperti gangguan fungsi ventrikel kiri, stroke volume yang menurun, regurgitasi katup mitral berulang, gangguan pada waktu pengisian diastolik hingga risiko tinggi untuk arritmia, serta hubungannya dengan peningkatan risiko trombosis. Sehingga semakin memperjelas pengaruh hiperglikemia yang tidak hanya dapat meningkatkan risiko terjadinya SKA, melainkan juga dapat memperburuk kondisi pasien SKA sendiri. Penelitian ini bertujuan mengidentifikasi hubungan kadar glukosa darah sewaktu dengan lama hari rawat pasien Sindrom Koroner Akut (SKA. Jenis penelitian yang digunakan adalah penelitian analitik dengan menggunakan desain penelitian Cross Sectional Study. Penelitian ini menggunakan data sekunder yang diambil di Instalasi Rekam Medik (Medical Record, yakni data rekam medik pasien yang didiagnosis sebagai Sindrom Koroner Akut (SKA yang dirawat inap di Rumah Sakit Umum Pusat DR. M. Djamil Padang Periode Januari–Desember 2011. Ditemukan sebagian besar pasien SKA masuk rumah sakit dengan kadar Glukosa Darah Sewaktu (GDS sebesar ≥ 200 mg/dl (40% dan lama hari rawat sebesar ≥ 7 hari (52%. Dari hasil analisa bivariat dengan menggunakan uji korelasi Spearman ditemukan adanya hubungan searah antara kadar glukosa darah saat masuk rumah sakit dengan lama hari rawat pasien SKA dengan kekuatan hubungan yang sedang, r = +0,492, p = 0, 000 (p<0,05. Pemantauan terhadap kadar GDS yang diperiksa saat pasien masuk rumah sakit perlu dilakukan dan untuk penelitian yang akan datang diharapkan dapat diteliti lebih lanjut faktor-faktor lain yang mempengaruhi lama hari rawat pasien SKA.Kata kunci: Kadar glukosa darah saat masuk RS, lama hari rawatAbstractHyperglicemia is still become a research

  20. The Last Interglacial-Glacial cycle (MIS 5-2) re-examined based on long proxy records from central and northern Europe

    Science.gov (United States)

    Helmens, Karin F.

    2014-02-01

    Current multi-proxy studies on a long sediment sequence preserved at Sokli (N Finland), i.e. in the central area of Fennoscandian glaciations, are drastically changing classic ideas of glaciations, vegetation and climate in northern Europe during the Late Pleistocene. The sediments in the Sokli basin have escaped major glacial erosion due to non-typical bedrock conditions. In this review, the Sokli record is compared in great detail with other long proxy records from central, temperate and northern, boreal Europe. These comprise the classic records of La Grande Pile (E France) and Oerel (N Germany) and more recently obtained records from Horoszki Duże (E Poland) and Lake Yamozero (NW Russia). The focus of the review is on pollen, lithology and macrofossil- and insect-based temperature inferences. The long records are further compared with recent proxy data from nearby terrestrial sites as well as with the rapidly accumulating high-resolution proxy data from the ocean realm. The comparison allows a re-examination of the environmental history and climate evolution of the Last Interglacial-Glacial (LI-G) cycle (MIS 5-2). It shows that environmental and climate conditions during MIS 5 (ca 130-70 ka BP) were distinctly different from those during MIS 4-2 (ca 70-15 ka BP). MIS 5 is characterized by three long forested intervals (broadly corresponding to MIS 5e, 5c, 5a), both in temperate and northern boreal Europe. These mild periods were interrupted by two short, relatively cold and dry intervals (MIS 5d and 5b) with mountain-centered glaciation in Fennoscandia. Millennial scale climate events were superimposed upon these longer lasting climate fluctuations. The time interval encompassing MIS 4-2 shows open vegetation. It is characterized by two glacial maxima (MIS 4 and 2) with sub-continental scale glaciation over northern Europe and dry conditions in strongly continental eastern European settings. High amplitude climate oscillations of millennial duration

  1. Super-plus - karpi pandud äike, mis tervistab / Tõnu Kalvet

    Index Scriptorium Estoniae

    Kalvet, Tõnu

    1999-01-01

    Venemaal toodetud õhupuhastist. Õhupuhasti ei piirdu mitte ainult õhu puhastamisega, vaid küllastab õhku ka osooniga ning eluks ülioluliste negatiivsete ioonidega, mis suurendavad organismi immuunsust ja likvideerivad alalise kurnatuse sündroomi

  2. Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population

    Directory of Open Access Journals (Sweden)

    Jie Gao

    2017-04-01

    Full Text Available Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN, however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561 in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR with 95% confidence intervals (CI. Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035. IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04. Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN.

  3. Effect of substrate mis-orientation on GaN thin films grown by MOCVD under different carrier gas condition

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seong-Woo; Suzuki, Toshimasa [Nippon Institute of Technology, 4-1 Gakuendai, Miyashiro, Saitama, 345-8501 (Japan); Aida, Hideo [NAMIKI Precision Jewel Co. Ltd., 3-8-22 Shinden, Adachi-ku, Tokyo, 123-8511 (Japan)

    2005-05-01

    We have studied the effect of a slight mis-orientation angle on surface and crystal quality of GaN thin films grown under different carrier gas conditions. Two types of carrier gas conditions were applied to the growth. One was pure H{sub 2} and the other was mixed N{sub 2}/H{sub 2}. As the result, we found dependence of surface and crystal quality of GaN thin films on the substrate mis-orientation angle, and they indicated almost the same tendency under both growth conditions. Therefore, it was confirmed that mis-orientation angle of sapphire substrate was one of the most critical factors for GaN thin films. Then, the effect of the additional N{sub 2} into the conventional H{sub 2} carrier gas was studied, and we found that the conversion of carrier gas from the conventional H{sub 2} to N{sub 2}/H{sub 2} mixture was effective against degradation of GaN crystallinity at any mis-orientation angle. Considering that the crystal quality of GaN thin films became insensitive to mis-orientation angle as the condition became more suitable for GaN growth, the optimal substrate mis-orientation angle was consequently decided to be approximately 0.15 from the morphological aspect. (copyright 2005 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  4. A climate model study of an intense Asian Monsoon in a La Niña-like climate of MIS-13

    Science.gov (United States)

    Karami, M. P.; Berger, A.; Herold, N.; Yin, Q. Z.

    2012-04-01

    Studying the paleo-monsoon during past interglacials is a valuable approach to improve our understanding of the monsoon system in present-day and future climates. We focus on Marine Isotopic stage 13 (MIS-13; ~0.5 Ma) which was a relatively cool interglacial, but with a paradoxically intense monsoonal precipitation over eastern and southern Asia. Our main goal is to understand the physics-based mechanism driving the intense monsoon, specifically the East Asian Summer Monsoon (EASM), during MIS-13. We applied both an intermediate complexity model (LOVECLIM) as well as fully coupled general circulation models (HadCM3 and CCSM3) to simulate pre-industrial and MIS-13 climates. The boundary conditions for MIS-13 were chosen for 506 ka with Northern-Hemisphere (NH) summer at perihelion and a CO2 concentration of 240 ppm. For pre-industrial, NH-winter occurring at perihelion and a CO2 concentration of 280 ppm were prescribed. Preliminary analysis of the model results shows different atmospheric and oceanic features in MIS-13 compared to the pre-industrial which could affect the EASM. The Northern Pacific Subtropical High (NPSH), which is an important factor in controlling the EASM, strengthened and extended to the northwest in MIS-13 partially due to cooling of the central Pacific Ocean. This in turn brought more moisture from the Central Pacific to the EASM-region and caused a northwestward shift and bending of the low-level jet along East Asia. The change in the low-level jet subsequently increased the meridional wind velocity at 850 mbar in the EASM-region providing more moisture from the tropical Pacific and Indian Oceans. In addition, higher sea-surface temperature in the Indian Ocean during MIS-13 further increased the source of moisture for the EASM. The Asian low, which is another component of the EASM-system, also shifted eastward moving the rain band northward. Moreover, it was found that MIS-13 had a dominant La Niña condition in the tropical Pacific. La Ni

  5. Comparison of the results of MIS-TLIF and open TLIF techniques in laborers

    Directory of Open Access Journals (Sweden)

    Daniel De Abreu Oliveira

    2014-01-01

    Full Text Available Objective: To compare clinical outcomes in laborers who have undergone open transforaminal interbody fusion (TLIF and minimally invasive transforaminal interbody fusion (MIS TLIF. Methods: 78 patients were submitted to lumbar arthrodesis by the same two spine surgeons partners from January 2008 to December 2012. Forty-one were submitted to traditional open arthrodesis and 37 to the minimally invasive procedure. Three patients were not included because they had already retired from work. The analyzed variables were length of hospitalization, length of follow-up, type of access (TILF or MIS TLIF, need for blood transfusion, percentage of improvement or worsening after surgery, pre- and postoperative VAS scale, time off work, pre-and postoperative Oswestry disability index, and general aspects of the laborers such as age, education, profession, working time, amount of daily weight carried at work, and use or not of personal protective equipment. Results: Time off work was longer in the TLIF group (average of 9.84 months compared with the MIS TLIF group (average of 3.20 months. Significant improvement in postoperative VAS and Oswestry was achieved in both groups. Average length of hospitalization was 5.73 days for the TLIF group and 2.76 days for the MIS TLIF group. Conclusions: Minimally invasive transforaminal lumbar interbody fusion presents similar results when compared to open TLIF, but has the benefits of less postoperative morbidity, shorter hospitalization times, and faster rehabilitation in laborer patients.

  6. Mis on papa Jannseni hind ? / Sven Sildnik ; interv. Grete Naaber

    Index Scriptorium Estoniae

    Sildnik, Sven, 1964-

    2006-01-01

    Sven Kivisildnik kirjutas Pärnu linnavalitsuse tellimusel Jannseni sünniaastapäeva peoks näidendi "Johann Woldemar Jannsen ehk Rahvavaenlase hind", mis kantakse ette Koidula muuseumi klassitoas 16. mail. Intervjuu näidendi autori ja esitajaga

  7. Neural circuitry governing anxious individuals' mis-allocation of working memory to threat.

    Science.gov (United States)

    Stout, Daniel M; Shackman, Alexander J; Pedersen, Walker S; Miskovich, Tara A; Larson, Christine L

    2017-08-18

    Dispositional anxiety is a trait-like phenotype that confers increased risk for a range of debilitating neuropsychiatric disorders. Like many patients with anxiety disorders, individuals with elevated levels of dispositional anxiety are prone to intrusive and distressing thoughts in the absence of immediate threat. Recent electrophysiological research suggests that these symptoms are rooted in the mis-allocation of working memory (WM) resources to threat-related information. Here, functional MRI was used to identify the network of brain regions that support WM for faces and to quantify the allocation of neural resources to threat-related distracters in 81 young adults. Results revealed widespread evidence of mis-allocation. This was evident in both face-selective regions of the fusiform cortex and domain-general regions of the prefrontal and parietal cortices. This bias was exaggerated among individuals with a more anxious disposition. Mediation analyses provided compelling evidence that anxious individuals' tendency to mis-allocate WM resources to threat-related distracters is statistically explained by heightened amygdala reactivity. Collectively, these results provide a neurocognitive framework for understanding the pathways linking anxious phenotypes to the development of internalizing psychopathology and set the stage for developing improved intervention strategies.

  8. Electrical properties of MBE grown Si{sub 3}N{sub 4}-cubic GaN MIS structures

    Energy Technology Data Exchange (ETDEWEB)

    Zado, A.; Lischka, K.; As, D.J. [University of Paderborn, Faculty of Science, Department of Physics, Warburger Str. 100, 33098 Paderborn (Germany)

    2012-03-15

    In this work we report on the electrical characterization of non-polar cubic GaN metal-insulator-semiconductor (MIS) structures. Si{sub 3}N{sub 4} layers were deposited in-situ on top of cubic GaN grown on 3C-SiC (001) substrates. The electric characteristics of the MIS structures are measured by capacitance and admittance spectroscopy techniques. From the hysteresis in the capacitance-voltage curves and the peak height of the conductance G{sub p} -{omega} frequency curves the interface state densities are calculated. We find interface traps about 0.3 eV below the conduction band. The density of these traps is D{sub it} = 2.5x10{sup 11} cm{sup -2}eV{sup -1}. This is one order of magnitude lower than in MIS structures with a Si{sub 3}N{sub 4} insulator produced by plasma enhanced vapour deposition and two orders of magnitude lower than in MIS structures on c-GaN with SiO{sub 2} as insulator (copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  9. Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy.

    Science.gov (United States)

    Tortajada, Agustín; Gutiérrez, Eduardo; Goicoechea de Jorge, Elena; Anter, Jaouad; Segarra, Alfons; Espinosa, Mario; Blasco, Miquel; Roman, Elena; Marco, Helena; Quintana, Luis F; Gutiérrez, Josué; Pinto, Sheila; Lopez-Trascasa, Margarita; Praga, Manuel; Rodriguez de Córdoba, Santiago

    2017-10-01

    IgA nephropathy (IgAN), a frequent cause of chronic kidney disease worldwide, is characterized by mesangial deposition of galactose-deficient IgA1-containing immune complexes. Complement involvement in IgAN pathogenesis is suggested by the glomerular deposition of complement components and the strong protection from IgAN development conferred by the deletion of the CFHR3 and CFHR1 genes (Δ CFHR3-CFHR1 ). Here we searched for correlations between clinical progression and levels of factor H (FH) and FH-related protein 1 (FHR-1) using well-characterized patient cohorts consisting of 112 patients with IgAN, 46 with non-complement-related autosomal dominant polycystic kidney disease (ADPKD), and 76 control individuals. Patients with either IgAN or ADPKD presented normal FH but abnormally elevated FHR-1 levels and FHR-1/FH ratios compared to control individuals. Highest FHR-1 levels and FHR-1/FH ratios are found in patients with IgAN with disease progression and in patients with ADPKD who have reached chronic kidney disease, suggesting that renal function impairment elevates the FHR-1/FH ratio, which may increase FHR-1/FH competition for activated C3 fragments. Interestingly, Δ CFHR3-CFHR1 homozygotes are protected from IgAN, but not from ADPKD, and we found five IgAN patients with low FH carrying CFH or CFI pathogenic variants. These data support a decreased FH activity in IgAN due to increased FHR-1/FH competition or pathogenic CFH variants. They also suggest that alternative pathway complement activation in patients with IgAN, initially triggered by galactose-deficient IgA1-containing immune complexes, may exacerbate in a vicious circle as renal function deterioration increase FHR-1 levels. Thus, a role of FHR-1 in IgAN pathogenesis is to compete with complement regulation by FH. Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  10. Determination of IL-1B (rs16944) and IL-6 (rs1800796) genetic polymorphisms in IgA nephropathy in a northwest Chinese Han population.

    Science.gov (United States)

    Zhang, Daofa; Xie, Maowei; Yang, Xiaohong; Zhang, Yin; Su, Yan; Wang, Yanni; Huang, Haiyang; Han, Hui; Li, Wenning; Fu, Keying; Su, Huiluan; Xu, Wentan; Han, Yeguang; Wang, Ru; Zhang, Pei; Wu, Wei; Huang, Yun; Chen, Daojun; Jin, Tianbo; Wei, Jiali

    2017-09-22

    IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, but etiology and pathogenesis continue to be poorly understood. Polymorphisms in the cytokine genes may play a role in the etiology and pathogenesis of IgAN. The incidence of different between diverse ethnic groups suggested important genetic influences on its pathogenesis. We genotype 10 single nucleotide polymorphisms (SNPs) in IL-1B and IL-6 gene using Sequenom Mass-ARRAY technology from 417 IgAN patients and 463 healthy controls of the Chinese Han population. We evaluated these SNPs associated with IgAN utilising the chi-square tests and genetic model analysis. We identified that the minor alleles of rs16944 ("A"), rs1800796 ("G") in IL-1B, IL-6 were involved in an increasingly risk of IgAN in allelic model analysis, respectively. The rs16944 in IL-1B and rs1800796 in IL-6 were associated with 1.23-fold (95% CI, 1.02-1.48, P = 0.031) and 1.33-fold (95% CI, 1.11-1.66, P = 0.003) increases in the risk of developing IgAN, respectively. There was only rs1800796 still correlated with IgAN in the allelic model after adjustment by age and gender and the Bonferroni correction. In addition, Haplotype G rs1800796 A rs2069837 G rs2069840 ( P = 0.037) and G rs1800796 A rs2069837 C rs2069840 ( P = 0.042) in IL-6 were considered to be associated with increased IgAN risk. This study verified the IL-6, IL-1B genetic variants polymorphisms contributed to IgAN susceptibility in a Chinese Han population. Although we identified SNPs susceptibility, however, replication studies and functional research are required to confirm the genetic contribution in IgAN.

  11. SITUASI VEKTOR DEMAM BERDARAH SAAT KEJADIAN LUAR BIASA (KLB DI KECAMATAN PASARREBO, JAKARTA TIMUR

    Directory of Open Access Journals (Sweden)

    M. Hasyimi

    2012-10-01

    Full Text Available Kejadian luar biasa (KLB penyakit Demam berdarah dengue (DBD sering terjadi sejak dilaporkan tahun 1968. Pemberantasannya dengan penemuan penderita, pengobatan dan pengendalian vektor. Karena obat dan vaksin belum ditemukan maka sampai saat ini pemberantasan dan pencegahannya masih mengandalkan pada pengendalian vektor. Tujuan dari penelitian vektor ini adalah untuk mendapatkan informasi tentang habitat perkembangbiakan, kepadatan larva dan nyamuk penular DBD pada waktu terjadi KLB serta tipe virus yang dikandung vektornya. Penelitian dilakukan di Kecamatan Pasar Rebo, Jakarta Timur selama tiga bulan yaitu Juni sampai dengan Agustus 2003. Penelitian entomologi dilakukan merujuk kepada alamat penderita rawat inap yang bertempat tinggal di Kecamatan Pasar Rebo. Diagnosa penderita dilakukan dengan uji Hemagglutination inhibition (HI terhadap 24 akut konvalesen sera penderita yang diambil dari Rumah Sakit Pasar Rebo. Basil penelitian menunjukkan bahwa index larva sebagai berikut House index (HI 22,6%; Container index (Cl 11,4% dan Breuteau index (Bl 30,3. Kontainer yang positif larva yang berada di dalam rumah 12, 7% dari 387 kontainer. Sementara yang berada di luar rumah 3,1% dari 65 kontainer. Angka bebas jentik (ABJ di daerah KLB kurang dari 95%. Hasil uji HI sera penderita menunjukkan 70,8% dari pasangan sera yang diperiksa, terinfeksi oleh virus dengue.

  12. Mis see jumal meid on loonud? / Rein Veidemann

    Index Scriptorium Estoniae

    Veidemann, Rein, 1946-

    2017-01-01

    Eesti teatriuuenduse 1969 aastal lavastas Evald Hermaküla Paul-Eerik Rummo näidendi "Tuhkatriinumäng", Jaan Tooming August Kitzbergi "Laseb käele suud anda". Jaak Alliku arvustus Jaan Toominga lavastusele ilmus ajakirjas Noorus 1970. aasta märtsinumbris pealkirjaga "Mis see jumal meid on loonud?". Sama küsimuse esitab artikli autor. Elumõttest, elu eesmärgist ja tähendusest

  13. ProMIS Augmented Reality Training of Laparoscopic Procedures Face Validity

    NARCIS (Netherlands)

    Botden, Sanne M. B. I.; Buzink, Sonja N.; Schijven, Marlies P.; Jakimowicz, Jack J.

    2008-01-01

    Background: Conventional video trainers lack the ability to assess the trainee objectively, but offer modalities that are often missing in virtual reality simulation, such as realistic haptic feedback. The ProMIS augmented reality laparoscopic simulator retains the benefit of a traditional box

  14. ProMIS augmented reality training of laparoscopic procedures face validity

    NARCIS (Netherlands)

    Botden, Sanne M. B. I.; Buzink, Sonja N.; Schijven, Marlies P.; Jakimowicz, Jack J.

    2008-01-01

    BACKGROUND: Conventional video trainers lack the ability to assess the trainee objectively, but offer modalities that are often missing in virtual reality simulation, such as realistic haptic feedback. The ProMIS augmented reality laparoscopic simulator retains the benefit of a traditional box

  15. Contrasting pollen histories of MIS 5e and the Holocene from Lake Titicaca (Bolivia/Peru)

    Science.gov (United States)

    Hanselman, Jennifer A.; Gosling, William D.; Paduano, Gina M.; Bush, Mark B.

    2005-10-01

    Two long sediment records (cores LTO1-2B and LT01-3B) from Lake Titicaca, Bolivia/Peru, are compared with a previously analysed Holocene record from this lake (core NE98-1PC). The Holocene records of LT01-2B and NE98-1PC are similar. There are striking differences, however, between the MIS 5e sections of the long cores and the Holocene records. In these records, temperature is probably the dominant parameter that determines the total fossil pollen concentration and is used to time the onset and termination of deglaciation. In contrast, the relative and absolute abundance of specific taxa (e.g. Polylepis/Acaena, Chenopodiaceae) are indicators of relative moisture availability. Although the Holocene contains a period of aridity between ca. 8000 cal. yr BP and 4300 cal. yr BP, it is a minor event compared with the more extreme aridity of MIS 5e. Core LT01-3B showed similar trends during MIS 5e when compared to LT01-2B, as did NE98-1PC when comparing Holocene records. MIS 5e and the Holocene are markedly different interglacials, depicted by shifts in pollen concentration and taxa representation over time.

  16. Memory effects in MIS structures based on silicon and polymethylmethacrylate with nanoparticle charge-storage elements

    Energy Technology Data Exchange (ETDEWEB)

    Mabrook, M.F. [School of Engineering and Centre for Molecular and Nanoscale Electronics, Durham University, South Road, Durham DH1 3LE (United Kingdom)], E-mail: m.f.mabrook@durham.ac.uk; Jombert, A.S. [School of Engineering and Centre for Molecular and Nanoscale Electronics, Durham University, South Road, Durham DH1 3LE (United Kingdom); Department of Chemistry, Durham University, South Road, Durham DH1 3LE (United Kingdom); Machin, S.E.; Pearson, C.; Kolb, D. [School of Engineering and Centre for Molecular and Nanoscale Electronics, Durham University, South Road, Durham DH1 3LE (United Kingdom); Coleman, K.S. [Department of Chemistry, Durham University, South Road, Durham DH1 3LE (United Kingdom); Zeze, D.A.; Petty, M.C. [School of Engineering and Centre for Molecular and Nanoscale Electronics, Durham University, South Road, Durham DH1 3LE (United Kingdom)

    2009-03-15

    We report on the electrical behaviour of metal-insulator-semiconductor (MIS) structures fabricated on p-type silicon substrates and using polymethylmethacrylate (PMMA) as the dielectric. Gold nanoparticles, single-wall carbon nanotubes and C{sub 60}, deposited at room temperature, were used as charge-storage elements. In all cases, the MIS devices containing the nanoparticles exhibited hysteresis in their capacitance versus voltage characteristics, with a memory window depending on the range of the voltage sweep. This hysteresis was attributed to the charging and discharging of the nanoparticles from the gate electrode. A relatively large memory window of about 2.2 V was achieved by scanning the applied voltage of an Al/PMMA/C{sub 60}/SiO{sub 2}/Si structure between 4 and -4 V. Gold nanoparticle-based memory devices produced the best charge retention behaviour compared to the other MIS structures investigated.

  17. Mis keelt räägib kuldsõdur? / Kristina Norman

    Index Scriptorium Estoniae

    Norman, Kristina, 1979-

    2009-01-01

    Kunstnik Kristina Norman oma Tõnismäe pronkssõduri monumenti käsitlevast kunstiprojektist "After-War", mis esindab Eestit 53. Veneetsia biennaalil, oma kunstnikupositsioonist, 9. mail kunstiprojekti osana toimunud aktsiooni, mil kunstnik viis Tallinnas Tõnismäele pronkssõduriga sarnase kuldse skulptuuri, eesmärgist

  18. Consequences of mis-loading and the power distribution in bowed fuel assemblies

    International Nuclear Information System (INIS)

    Andersson, Magnus

    2002-04-01

    The thesis is divided in two parts. The first part will investigate consequences of a mis-loaded fuel assembly in Ringhals 3, which is a pressurised water reactor (PWR). The aim of this work is to show that there are no or very small benefits from making an additional flux map at 30 % power in order to detect anomalies. Out of the 17 simulations, there exists only one type of mis-loading, which leads to problems. The case, which leads to problems, is when a Gd fitted assembly changes place with a non Gd. This leads to a too high power peaking factor and increased quadrant power tilt. The gain of a flux map at 30% power is small

  19. Consequences of mis-loading and the power distribution in bowed fuel assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Magnus

    2002-04-01

    The thesis is divided in two parts. The first part will investigate consequences of a mis-loaded fuel assembly in Ringhals 3, which is a pressurised water reactor (PWR). The aim of this work is to show that there are no or very small benefits from making an additional flux map at 30 % power in order to detect anomalies. Out of the 17 simulations, there exists only one type of mis-loading, which leads to problems. The case, which leads to problems, is when a Gd fitted assembly changes place with a non Gd. This leads to a too high power peaking factor and increased quadrant power tilt. The gain of a flux map at 30% power is small.

  20. Stipendiumiprogramm, mis suunatud stimuleerima noorte arengut / Viire Sepp

    Index Scriptorium Estoniae

    Sepp, Viire, 1955-

    2014-01-01

    Programmist, mis väärtustab reaalainete olümpiaade, kui võimekate noorte arengu üht olulist stiimulit. Tallinna Tehnikaülikooli üliõpilase Mette Purde, Harvardi ülikooli üliõpilase Erik Tamre, Cambridge'i ülikooli üliõpilase Jaan Tootsi ning Tartu Ülikooli üliõpilaste Janno Veeorg, Lona Liisa Sutt, Madis Ollikainen ja Jaagup Repän arvamused olümpiaadide olulisusest

  1. Predicting Post-Transplant Recurrence of IgA Nephropathy: The Importance of Crescents.

    Science.gov (United States)

    Avasare, Rupali S; Rosenstiel, Paul E; Zaky, Ziad S; Tsapepas, Demetra S; Appel, Gerald B; Markowitz, Glen S; Bomback, Andrew S; Canetta, Pietro A

    2017-01-01

    Most studies that have assessed the predictors of recurrent IgA nephropathy (IgAN) in the renal allograft have focused on post-transplant features. Identifying high-risk pre-transplant features of IgAN is useful for counseling patients and may help in tailoring post-transplant immunosuppression. We investigated the pre-transplant clinical and biopsy features of 62 patients with IgAN who received transplants at Columbia University Medical Center from 2001 to 2012 and compared the characteristics and outcomes of patients with IgAN recurrence to those without recurrence. The primary outcome was time to recurrent IgAN. Secondary outcomes were a composite of doubling of creatinine or allograft failure, and recurrent IgAN as a cause of allograft dysfunction. Of the 62 patients, 14 had recurrent IgAN in the allograft. Mean time to recurrence was 2.75 years. Those with recurrent disease were younger at the time of native kidney biopsy (29 vs. 41 years, p < 0.0009). Black race and Hispanic ethnicity composed a higher proportion of the recurrent disease group. On multivariable analysis, significant predictors of recurrent IgAN included age at diagnosis (hazards ratio (HR) 0.911, 95% CI 0.85-0.98), burden of crescents on native biopsy (HR 1.21 per 10% increase in crescents, 95% CI 1.00-1.47) and allograft rejection (HR 3.59, 95% CI 1.10-11.7). Features of native IgAN can help predict the risk of recurrent disease in the renal allograft. In particular, immunologically active disease represented by earlier age of onset and greater burden of crescents on native biopsy is more likely to recur after transplant. © 2017 S. Karger AG, Basel.

  2. Nuclear criticality safety: general. 4. The CASTOR X/32S Method of Covering mis-loading Concerns

    International Nuclear Information System (INIS)

    Lancaster, Dale B.; Rombough, Charles T.; Diersch, Rudolf; Spilker, Harry

    2001-01-01

    In the United States, most cask licenses do not directly consider mis-loading. If the enrichment limit for a shipping cask is high and the reactivity control is inherent in the cask, the reactivity effect of a mis-load is small. However, in large-capacity casks, such as the CASTOR X/32S, the effect can be much larger. The U.S. Department of Energy Topical Report on Actinide- Only Burnup Credit takes the position that a fuel assembly mis-load does need to be analyzed since there are multiple independent checks, and thus, the double-contingency principle is met. Unfortunately, 11 assemblies were mis-loaded at Palisades. This event has caused the U.S. Nuclear Regulatory Commission (NRC) to ask for more detail on prevention of mis-loading. In the summer of 1999, Palisades loaded 11 assemblies, which did not comply with the loading requirements for their VSC-24 cask. The cask requires 5 yr of cooling, and these 11 assemblies had just a little more than 4 yr of cooling. The mis-loading did not result in an unsafe condition but in an un-reviewed condition. This mis-loading was not identified until November 2000 during a review related to an NRC information notice. The loading plan for the cask was incorrect. The engineering review of the loading plan missed the error. The operators had loaded the cask consistent with the loading plan. The cask loading was then confirmed by comparing to the loading plan. The loading plan was in error since the engineer assumed that the entire region of fuel was discharged at the same time. The 11 assemblies of concern were reinserted in the reactor, and the engineer and the reviewer did not check for this. The reactor records for all the assemblies were correct but apparently were not checked by the engineer who created the loading plan. To prevent a mis-load criticality event, the following steps will be required for the CASTOR X/32S storage and transport cask: 1. A loading plan will be prepared for each cask loaded. This plan will be

  3. Pinning-free GaAs MIS structures with Si interface control layers formed on (4 x 6) reconstructed (0 0 1) surface

    Energy Technology Data Exchange (ETDEWEB)

    Anantathanasarn, Sanguan; Hasegawa, Hideki

    2003-06-30

    (0 0 1)-Oriented GaAs metal-insulator-semiconductor (MIS) structures having a silicon interface control layer (Si ICL) were fabricated on surfaces having Ga-rich (4x6) reconstructions. Si ICL was grown by molecular beam epitaxy. MIS structures were fabricated by partially converting Si ICL to SiN{sub x} by direct nitridation, and further depositing a thick SiO{sub 2} layer on top as the main passivation dielectric by plasma-assisted chemical vapor deposition. Reflection high-energy electron diffraction, in situ X-ray photoelectron spectroscopy and MIS capacitance-voltage (C-V) techniques were used for characterization. The initial surface reconstruction was found to have a surprisingly strong effect on the degree of Fermi level pinning at the MIS interface. In contrast to the standard As-rich (2x4) surface, which results in strongly pinned MIS interfaces, the novel SiO{sub 2}/SiN{sub x}/Si ICL/GaAs MIS structures formed on ''genuine'' (4x6) surface realized complete unpinning of Fermi level over the entire band gap with a minimum interface state density of 4x10{sup 10} cm{sup -2} eV{sup -1} range.

  4. The IgA nephropathy Biobank. An important starting point for the genetic dissection of a complex trait

    Directory of Open Access Journals (Sweden)

    Alexopoulos Efstathios

    2005-12-01

    Full Text Available Abstract Background IgA nephropathy (IgAN or Berger's disease, is the most common glomerulonephritis in the world diagnosed in renal biopsied patients. The involvement of genetic factors in the pathogenesis of the IgAN is evidenced by ethnic and geographic variations in prevalence, familial clustering in isolated populations, familial aggregation and by the identification of a genetic linkage to locus IGAN1 mapped on 6q22–23. This study seems to imply a single major locus, but the hypothesis of multiple interacting loci or genetic heterogeneity cannot be ruled out. The organization of a multi-centre Biobank for the collection of biological samples and clinical data from IgAN patients and relatives is an important starting point for the identification of the disease susceptibility genes. Description The IgAN Consortium organized a Biobank, recruiting IgAN patients and relatives following a common protocol. A website was constructed to allow scientific information to be shared between partners and to divulge obtained data (URL: http://www.igan.net. The electronic database, the core of the website includes data concerning the subjects enrolled. A search page gives open access to the database and allows groups of patients to be selected according to their clinical characteristics. DNA samples of IgAN patients and relatives belonging to 72 multiplex extended pedigrees were collected. Moreover, 159 trios (sons/daughters affected and healthy parents, 1068 patients with biopsy-proven IgAN and 1040 healthy subjects were included in the IgAN Consortium Biobank. Some valuable and statistically productive genetic studies have been launched within the 5th Framework Programme 1998–2002 of the European project No. QLG1-2000-00464 and preliminary data have been published in "Technology Marketplace" website: http://www.cordis.lu/marketplace. Conclusion The first world IgAN Biobank with a readily accessible database has been constituted. The knowledge gained

  5. A comparative study between matched and mis-matched projection/back projection pairs used with ASIRT reconstruction method

    International Nuclear Information System (INIS)

    Guedouar, R.; Zarrad, B.

    2010-01-01

    For algebraic reconstruction techniques both forward and back projection operators are needed. The ability to perform accurate reconstruction relies fundamentally on the forward projection and back projection methods which are usually, the transpose of each other. Even though the mis-matched pairs may introduce additional errors during the iterative process, the usefulness of mis-matched projector/back projector pairs has been proved in image reconstruction. This work investigates the performance of matched and mis-matched reconstruction pairs using popular forward projectors and their transposes when used in reconstruction tasks with additive simultaneous iterative reconstruction techniques (ASIRT) in a parallel beam approach. Simulated noiseless phantoms are used to compare the performance of the investigated pairs in terms of the root mean squared errors (RMSE) which are calculated between reconstructed slices and the reference in different regions. Results show that mis-matched projection/back projection pairs can promise more accuracy of reconstructed images than matched ones. The forward projection operator performance seems independent of the choice of the back projection operator and vice versa.

  6. A comparative study between matched and mis-matched projection/back projection pairs used with ASIRT reconstruction method

    Energy Technology Data Exchange (ETDEWEB)

    Guedouar, R., E-mail: raja_guedouar@yahoo.f [Higher School of Health Sciences and Techniques of Monastir, Av. Avicenne, 5060 Monastir, B.P. 128 (Tunisia); Zarrad, B., E-mail: boubakerzarrad@yahoo.f [Higher School of Health Sciences and Techniques of Monastir, Av. Avicenne, 5060 Monastir, B.P. 128 (Tunisia)

    2010-07-21

    For algebraic reconstruction techniques both forward and back projection operators are needed. The ability to perform accurate reconstruction relies fundamentally on the forward projection and back projection methods which are usually, the transpose of each other. Even though the mis-matched pairs may introduce additional errors during the iterative process, the usefulness of mis-matched projector/back projector pairs has been proved in image reconstruction. This work investigates the performance of matched and mis-matched reconstruction pairs using popular forward projectors and their transposes when used in reconstruction tasks with additive simultaneous iterative reconstruction techniques (ASIRT) in a parallel beam approach. Simulated noiseless phantoms are used to compare the performance of the investigated pairs in terms of the root mean squared errors (RMSE) which are calculated between reconstructed slices and the reference in different regions. Results show that mis-matched projection/back projection pairs can promise more accuracy of reconstructed images than matched ones. The forward projection operator performance seems independent of the choice of the back projection operator and vice versa.

  7. The importance of sensitive screening for abnormal glucose metabolism in patients with IgA nephropathy.

    Science.gov (United States)

    Jia, Xiaoyuan; Pan, Xiaoxia; Xie, Jingyuan; Shen, Pingyan; Wang, Zhaohui; Li, Ya; Wang, Weiming; Chen, Nan

    2016-01-01

    To investigate the prevalence of abnormal glucose metabolism, insulin resistance (IR) and the related risk factors in IgA nephropathy (IgAN) patients. We analyzed oral glucose tolerance test (OGTT) and clinical data of 107 IgAN patients and 106 healthy controls. Glucose metabolism, homeostasis model assessment of insulin resistance (HOMA-IR) and the insulin sensitivity index (ISI) of both groups were evaluated. The prevalence of abnormal glucose metabolism was significantly higher in the IgAN group than in the control group (41.12% vs. 9.43%, p glucose, fasting insulin, OGTT 2-hour blood glucose, OGTT 2-hour insulin, HOMA-IR, and lower ISI than healthy controls. Triglyceride (OR = 2.55), 24-hour urine protein excretion (OR = 1.39), and age (OR = 1.06) were independent risk factors for abnormal glucose metabolism in IgAN patients. BMI, eGFR, 24-hour urine protein excretion, triglyceride, fasting blood glucose, fasting insulin, OGTT 2-hour blood glucose, and OGTT 2-hour insulin were significantly higher in IgAN patients with IR than in IgAN patients without IR, while HDL and ISI were significantly lower. BMI, serum albumin, and 24-hour urine protein excretion were correlated factors of IR in IgAN patients. Our study highlighted that abnormal glucose metabolism was common in IgAN patients. Triglyceride and 24-hour urine protein excretion were significant risk factors for abnormal glucose metabolism. Therefore, sensitive screening for glucose metabolism status and timely intervention should be carried out in clinical work.

  8. Insights into North Atlantic deep water formation during the peak interglacial interval of Marine Isotope Stage 9 (MIS 9)

    Science.gov (United States)

    Mokeddem, Zohra; McManus, Jerry F.

    2017-11-01

    Foraminifera abundance and stable isotope records from ODP Site 984 (61.25°N, 24.04°W, 1648 m) in the North Atlantic are used to reconstruct surface circulation variations and the relative strength of the North Atlantic Deep Water (NADW) formation over the period spanning the peak warmth of Marine Interglacial Stage (MIS) 9e ( 324-336 ka). This interval includes the preceding deglaciation, Termination 4 (T4), and the subsequent glacial inception of MIS 9d. The records indicate a greatly reduced contribution of NADW during T4, as observed in more recent deglaciations. In contrast with the most recent deglaciation, the lack of a significant NADW signal extended from T4 well into the peak interglacial MIS 9e and persisted nearly until the transition to the subsequent glacial stage MIS 9d. Although NADW formation resumed during MIS 9e, only depths greater than 2000 m appear to have been ventilated. The poorly ventilated intermediate depth of Site 984 (<2000 m) may have resulted on one hand from a general reduction of deep water ventilation by NADW during the study interval or, on the other hand, from different pathways of the spread of newly formed NADW that bypassed the study location. The intermediate depths may have also been invaded by southern-sourced waters as the formation of intermediate depth NADW weakened. The absence of any significant NADW signal at the water depth of Site 984 during the climatic optimum contrasts sharply with subsequent interglacial peaks (MIS 5e and the Holocene). Despite the perturbed intermediate depth circulation, oceanic heat transport northeastward was not interrupted and may have contributed to the relatively mild interglacial conditions of MIS 9e.

  9. Significance of urinary full-length megalin in patients with IgA nephropathy.

    Directory of Open Access Journals (Sweden)

    Takuto Seki

    Full Text Available BACKGROUND AND OBJECTIVES: Megalin is highly expressed at the apical membranes of proximal tubular epithelial cells. A urinary full-length megalin (C-megalin assay is linked to the severity of diabetic nephropathy in type 2 diabetes. This study examined the relationship between levels of urinary C-megalin and histological findings in adult patients with IgA nephropathy (IgAN. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Urine samples voided in the morning on the day of renal biopsy were obtained from 73 patients with IgAN (29 men and 44 women; mean age, 33 years and 5 patients with membranous nephropathy (MN. Renal pathologic variables were analyzed using the Oxford classification of IgAN, the Shigematsu classification and the Clinical Guidelines of IgAN in Japan. The levels of urinary C-megalin were measured by sandwich ELISA. RESULTS: Histological analysis based on the Oxford classification revealed that the levels of urinary C-megalin were correlated with mesangial hypercellularity in IgAN patients (OR = 1.76, 95% CI: 1.04-3.27, P<0.05. There was a significant correlation between the levels of urinary C-megalin and the severity of chronic extracapillary abnormalities according to the Shigematsu classification in IgAN patients (β = 0.33, P = 0.008. The levels of urinary C-megalin were significantly higher in all risk levels of IgAN patients requiring dialysis using the Clinical Guidelines of IgAN in Japan than in the control group. The levels of urinary C-megalin were significantly higher in the high risk and very high risk grades than in the low risk grade (P<0.05. The levels of urinary C-megalin were significantly higher in MN patients compared to the control group. CONCLUSIONS: The levels of urinary C-megalin are associated with histological abnormalities in adult IgAN patients. There is a possibility that urinary C-megalin is an independent predictor of disease progression of IgAN. In addition, our results suggest that

  10. 1.0 MeV irradiation of OHMIC, MS, MIS contacts to InP

    International Nuclear Information System (INIS)

    Warren, C.E.; Wagner, B.F.; Anderson, W.A.

    1986-01-01

    The radiation effects of 1.0 MeV electrons with a dose of 10/sup 15/cm/sup -2/ to MS and MIS Schottky diodes on InP have been compared to the radiation effects of MIS diodes on GaAs and Si. The radiation effects to ohmic contacts were also investigated. The metal for the diodes on the InP was gold. Au/Ti/Al was used for the GaAs diodes and Cr for the silicon diodes. Oxide layers on InP were grown by anodization in 0.1 N KOH. Oxides to GaAs and Si were grown thermally. Ohmic contacts to InP were formed using AuGe/Ni and AuSn alloys, followed by annealing in N/sub 2//H/sub 2/ (85%/15%). Metal Semiconductor diodes on InP were found to be at least sensitive to the irradiation. The InP MS and MIS diodes showed only small changes in the current voltage (I-V) characteristic, whereas the GaAs and Si devices showed a decrease in reverse current after irradiation. The ohmic contact resistance was increased by a factor of 2 to 5 after irradiation

  11. Mis oli ja mida ei olnud : lisandusi kahele kirjutisele / Tiiu Erelt

    Index Scriptorium Estoniae

    Erelt, Tiiu, 1942-

    2008-01-01

    Lisandusi artiklitele: Koppel, Margit-Mariann. Mahalaskmine pärast surma //Eesti Ekspress, 23. aug. 2007, mis käsitleb Elmar Muugi saatust, ning: Raag, Raimo. Valter Tauli elust ja keelelisest tegevusest // Keel ja Kirjandus, (2007/Nov), nr. 11

  12. The role of {sup 60}Co gamma-ray irradiation on the interface states and series resistance in MIS structures

    Energy Technology Data Exchange (ETDEWEB)

    Tascioglu, Ilke [Department of Physics, Faculty of Science and Arts, Gazi University, 06500 Ankara (Turkey); Tataroglu, Adem, E-mail: ademt@gazi.edu.t [Department of Physics, Faculty of Science and Arts, Gazi University, 06500 Ankara (Turkey); Ozbay, Akif; Altindal, Semsettin [Department of Physics, Faculty of Science and Arts, Gazi University, 06500 Ankara (Turkey)

    2010-04-15

    The effect of gamma-ray exposure on the metal-insulator-semiconductor (MIS) structures has been investigated using the electrical characteristics at room temperature. The MIS structures are irradiated with {sup 60}Co gamma-ray source. The energy distribution of interface states was determined from the forward bias I-V characteristics by taking into account the bias dependence of the effective barrier height and ideality factor. The value of series resistance decreases with increasing dose. Experimental results confirmed that gamma-ray irradiation have a significant effect on electrical characteristics of MIS structures.

  13. Identification of distinct glycoforms of IgA1 in plasma from patients with IgA nephropathy and healthy individuals

    DEFF Research Database (Denmark)

    Lehoux, Sylvain; Mi, Rongjuan; Aryal, Rajindra P

    2014-01-01

    Immunoglobulin A nephropathy (IgAN) is the most common form of glomerulonephritis worldwide and is histologically characterized by the deposition of IgA1 and consequent inflammation in the glomerular mesangium. Prior studies suggested that serum IgA1 from IgAN patients contains aberrant, undergal......Immunoglobulin A nephropathy (IgAN) is the most common form of glomerulonephritis worldwide and is histologically characterized by the deposition of IgA1 and consequent inflammation in the glomerular mesangium. Prior studies suggested that serum IgA1 from IgAN patients contains aberrant...... there are different glycoforms of IgA1 in plasma from patients with IgAN and healthy individuals. While total plasma IgA in IgAN patients was elevated ~1.6-fold compared to that in healthy donors, IgA1 in all samples was unexpectedly separable into two distinct glycoforms: one with core 1 based O......-glycans, and the other exclusively containing Tn/STn structures. Importantly, Tn antigen present on IgA1 from IgAN patients and controls was convertible into the core 1 structure in vitro by recombinant T-synthase. Our results demonstrate that undergalactosylation of O-glycans in IgA1 is not restricted to Ig...

  14. Film, mis mõjub / Anne Applebaum ; tõlk. Kaarel Tarand

    Index Scriptorium Estoniae

    Applebaum, Anne

    2008-01-01

    Ajalehes The New York Review of Books (14. II) ilmunud artikkel poola režissööri Andrzej Wajda filmist "Katõn", mis räägib Katõni massimõrvast. Andrzej Wajda pälvis sel aastal Eesti presidendilt Maarjamaa Risti III klassi teenetemärgi

  15. Hubungan Kadar Gula Darah saat Masuk Rumah Sakit dengan Jenis Sindroma Koroner Akut di RS Dr. M. Djamil Padang

    Directory of Open Access Journals (Sweden)

    Willy Valerian

    2015-05-01

    Full Text Available AbstrakSindrom Koroner Akut (SKA merupakan spektrum dari penyakit arteri koroner yang tidak stabil, mulai dari angina pektoris tidak stabil sampai infark miokardium. SKA terbagi atas Unstable Angina Pectoris (UAP, ST elevation myocardial infarction (STEMI, Non-ST elevation myocardial infarction (NSTEMI. Tujuan penelitian ini adalah untuk menentukan hubungan antara kadar gula darah saat masuk rumah sakit dan jenis SKA. Metode penelitian yang digunakan adalah cross sectional. Penelitian dilakukan di Instalasi Rekam Medik RS Dr. M. Djamil Padang dengan mengambil data pasien SKA dari Januari 2012 sampai Desember 2012. Hasil penelitian ini didapatkan jenis SKA dengan gula darah yang tidak normal dari 60 sampel, yaitu: UAP 25%, NSTEMI 35%, STEMI 40%. Hasil pengolahan data dapat dilihat bahwa nilai p = 0,592 yang artinya tidak terdapat hubungan yang bermakna antara kadar gula darah saat masuk rumah sakit dengan jenis SKA. Hal ini terjadi mungkin karena terlalu sedikitnya sampel dan banyak sampel kriteria ekslusi dalam pencarian data. Sebaiknya dalam penelitian yang akan datang dapat memperbanyak sampel.Kata kunci: sindrom koroner akut, kadar gula darah, hubungan kadar gula darah dengan SKA AbstractAcute Coronary Syndrome (ACS is a spectrum of coronary artery disease that is not stable, ranging from unstable angina to myocardial infarction. Acute Coronary Syndrome is divided into Unstable Angina Pectoris (UAP, ST elevation myocardial infarction (STEMI, non-ST elevation myocardial infarction (NSTEMI. The objective of this study was to determine the relationship between blood sugar levels when admitted to hospital and Acute Coronary Syndrome type by using cross sectional study. The study was conducted at the Medical Records RS Dr. M. Djamil Padang. The ACS data collected from January 2012 until December 2012. The results of this study was found the SKA with abnormal blood sugar of 60 samples, i.e. UAP25%, NSTEMI35%, 40% STEMI. On the results of data

  16. Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila

    Science.gov (United States)

    Werz, Christian; Lee, Tom V.; Lee, Peter L.; Lackey, Melinda; Bolduc, Clare; Stein, David S.; Bergmann, Andreas

    2009-01-01

    Summary Incorrectly specified or mis-specified cells often undergo cell death or are transformed to adopt a different cell fate during development. The underlying cause for this distinction is largely unknown. In many developmental mutants in Drosophila, large numbers of mis-specified cells die synchronously, providing a convenient model for analysis of this phenomenon. The maternal mutant bicoid is particularly useful model with which to address this issue because its mutant phenotype is a combination of both transformation of tissue (acron to telson) and cell death in the presumptive head and thorax regions. We show that a subset of these mis-specified cells die through an active gene-directed process involving transcriptional upregulation of the cell death inducer hid. Upregulation of hid also occurs in oskar mutants and other segmentation mutants. In hid bicoid double mutants, mis-specified cells in the presumptive head and thorax survive and continue to develop, but they are transformed to adopt a different cell fate. We provide evidence that the terminal torso signaling pathway protects the mis-specified telson tissue in bicoid mutants from hid-induced cell death, whereas mis-specified cells in the head and thorax die, presumably because equivalent survival signals are lacking. These data support a model whereby mis-specification can be tolerated if a survival pathway is provided, resulting in cellular transformation. PMID:16280349

  17. A Perspective on a Management Information Systems (MIS) Program Review

    Science.gov (United States)

    Yew, Bee K.

    2008-01-01

    This paper highlights relevant curriculum issues that were identified in a Management Information Systems (MIS) program review undertaken by a group of business faculty in a small regional university. The program review was initiated to improve job marketability of graduates and student enrollment. The review process is described as a collective…

  18. Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA Nephropathy

    Directory of Open Access Journals (Sweden)

    Mototsugu Tanaka

    2011-01-01

    Full Text Available Predominant or codominant immunoglobulin (Ig A deposition in the glomerular mesangium characterizes IgA nephropathy (IgAN. Accumulated glomerular IgA is limited to the IgA1 subclass and usually galactose-deficient. This underglycosylated IgA may play an important role in the pathogenesis of IgAN. Recently, antibodies against galactose-deficient IgA1 were found to be well associated with the development of IgAN. Several therapeutic strategies based on corticosteroids or other immunosuppressive agents have been shown to at least partially suppress the progression of IgAN. On the other hand, several case reports of kidney transplantation or acquired IgA deficiency uncovered a remarkable ability of human kidney to remove mesangial IgA deposition, resulting in the long-term stabilization of kidney function. Continuous exposure to circulating immune complexes containing aberrantly glycosylated IgA1 and sequential immune response seems to be essential in the disease progression of IgAN. Removal of mesangial IgA deposition may be a challenging, but fundamental approach in the treatment of IgAN.

  19. Indian Summer Monsoon dynamics during Termination II and MIS 5e

    Science.gov (United States)

    Magiera, Matthias; Erhardt, Andrea M.; Hartland, Adam; Kwiecien, Ola; Cheng, Hai; Immenhauser, Adrian; Turchyn, Alexandra; Breitenbach, Sebastian F. M.

    2017-04-01

    The interpretation of speleothem oxygen isotope ratios (δ18O) as proxy for Indian Summer Monsoon (ISM) dynamics is ambiguous, due to multiple influencing factors. Here we combine δ18O and calcium isotope δ44Ca analyses with elemental data to delineate regional shifts in moisture source, local rainfall amount, and changes in ISM intensity and length during Termination II and MIS 5e. Oxygen isotope ratios reflect a mixed signal of moisture source dynamics and rainfall amount; δ44Ca and Mg/Ca ratios are interpreted as proxies for local effective moisture and prior calcite precipitation (PCP) in the epikarst. The age of stalagmite MAW-3 from Mawmluh Cave, NE India, is constraint by six U-series dates. 108 samples, obtained at 0.4 mm resolution from the 70 mm long speleothem sample, have been analysed for δ18O, δ44Ca and Mg/Ca. Oxygen isotope ratios were measured on a ThermoFisher Scientific MAT 253 at Ruhr-University Bochum. Elemental ratios were measured on a quadrupole ICP-MS at Waikato University. Calcium isotope ratios were analyzed on a ThermoFisher Scientific Triton at University of Cambridge. MAW-3 grew from 136 kyrs BP to 96 kyrs BP, covering Termination II and MIS 5e. Oxygen isotope values are high (ca. +0.91 ‰) during Termination II, reach a minimum during MIS 5e (-3.5 ‰), and rise again to -0.2 ‰ at the end of MIS 5e. Calcium isotope ratios range from -0.32 ‰ to -0.70 ‰ and show a positive correlation (R2= 0.7) with δ18O. High δ18O values during Termination II reflect reduced atmospheric circulation and/or a proximal moisture source (Bay of Bengal), implying lowered ISM intensity. A positive correlation of δ18O with δ44Ca suggests concurrent changes of moisture source location and local rainfall amount, with a proximal moisture source and reduced effective rainfall during periods of weak ISM. Elevated Mg/Ca ratios at such intervals corroborate PCP occurrence, which reflects dry conditions. The beginning of MIS 5e (ca. 132 kyrs BP) is

  20. Refining the timing of the MIS 5e signal, West Caicos, Bristish West Indies:implications for paleoclimatic interpretation of the stratigraphic record

    Science.gov (United States)

    Kerans, C.; Zahm, C.; Bachtel, S.; Hearty, P.; Cheng, H.

    2017-12-01

    The progressive refinement of the Last Interglacial (LIG) tropical carbonate record has focused attention on the dramatically abrupt and episodic nature of this critical approximate 12 ka time window. From initial carbonate platform flooding at 133 ka to rapid sea level fall and exposure at 118 ka, the majority of present-day Bahamian and Caribbean strata were produced in a remarkably similar pattern extending from Bermuda and the Bahamas through the Cayman Islands, Yucatan, and south to the Dominican Republic. The position of coral reefs and oolitic sands of the LIG to a first order fit the global insolation-driven climate warming signal. Less well accepted/resolved is the existence of two distinct SL peaks with an intervening sea level fall implying a non-orbitally forced climate shift during this broader highstand. West Caicos, a 10 x 5 km leeward island on the Caicos Platform is an excellent example of LIG carbonate stratigraphic complexity. We collected sub-meter-resolution whole-island airborn LIDAR and decimeter-resolution UAV-constructed DEM's of the western and southern coastal outcrops to serve as a base for decimeter-scale mapping of the MIS 11, 7?, 5e, and Holocene units of the island, with particular focus on the continuous 8.4 km west coast outcrop of the MIS 5e. Seventy-five AAR relative age assignments from ooid separates, pinned by 16 U/Th dates from corals coming from MIS stage 11, lower MIS 5e, and upper MIS 5e reefs helped establish the age model for the Pleistocene-Holocene stratigraphy. The lower MIS 5e reef system averages 128 ka with an onset age of 133 ka. Upper MIS 5e corals ranges from 123 ka to 116 ka, bracketing the intra-MIS 5e sea-level fall between to approximately 125 ka. The intra-MIS 5e fall is a distinct erosional unconformity across 5 km of continuous outcrop, truncating the upper 2.5 m of lower 5e reef. The complexity of MIS 5e record on West Caicos and in the Northern Atlantic and Caribbean platforms regionally provides

  1. Electrical characteristics of {sup 60}Co {gamma}-ray irradiated MIS Schottky diodes

    Energy Technology Data Exchange (ETDEWEB)

    Tataroglu, A. [Department of Physics, Faculty of Arts and Sciences, Gazi University, 06500 Ankara (Turkey)]. E-mail: ademt@gazi.edu.tr; Altindal, S. [Department of Physics, Faculty of Arts and Sciences, Gazi University, 06500 Ankara (Turkey)

    2006-11-15

    In order to interpret the effect of {sup 60}Co {gamma}-ray irradiation dose on the electrical characteristics of MIS Schottky diodes, they were stressed with a zero bias at 1 MHz in dark and room temperature during {gamma}-ray irradiation and the total dose range was 0-450 kGy. The effect of {gamma}-ray exposure on the electrical characteristics of MIS Schottky diodes has been investigated using C-V and G/{omega}-V measurements at room temperature. Experimental results show that {gamma}-ray irradiation induces a decrease in the barrier height {phi} {sub B} and series resistance R {sub s}, decreasing with increasing dose rate. Also, the acceptor concentration N {sub A} increases with increasing radiation dose. The C-V characteristics prove that there is a reaction for extra recombination centers in case of MIS Schottky diodes exposed to {gamma}-ray radiation. Furthermore, the density of interface states N {sub ss} by Hill-Coleman method increases with increasing radiation dose. Experimental results indicate that the interface-trap formation at high irradiation dose is reduced due to positive charge build-up in the Si/SiO{sub 2} interface (due to the trapping of holes) that reduces the flow rate of subsequent holes and protons from the bulk of the insulator to the Si/SiO{sub 2} interface.

  2. Luminance compensation for AMOLED displays using integrated MIS sensors

    Science.gov (United States)

    Vygranenko, Yuri; Fernandes, Miguel; Louro, Paula; Vieira, Manuela

    2017-05-01

    Active-matrix organic light-emitting diodes (AMOLEDs) are ideal for future TV applications due to their ability to faithfully reproduce real images. However, pixel luminance can be affected by instability of driver TFTs and aging effect in OLEDs. This paper reports on a pixel driver utilizing a metal-insulator-semiconductor (MIS) sensor for luminance control of the OLED element. In the proposed pixel architecture for bottom-emission AMOLEDs, the embedded MIS sensor shares the same layer stack with back-channel etched a Si:H TFTs to maintain the fabrication simplicity. The pixel design for a large-area HD display is presented. The external electronics performs image processing to modify incoming video using correction parameters for each pixel in the backplane, and also sensor data processing to update the correction parameters. The luminance adjusting algorithm is based on realistic models for pixel circuit elements to predict the relation between the programming voltage and OLED luminance. SPICE modeling of the sensing part of the backplane is performed to demonstrate its feasibility. Details on the pixel circuit functionality including the sensing and programming operations are also discussed.

  3. Von Krahli akadeemikud küsivad, mis tuleb pärast kapitalismi

    Index Scriptorium Estoniae

    2008-01-01

    Oktoobris Von Krahli Akadeemias toimuvast neljaosalisest loengusarjast, mis otsib vastust küsimusele - kas on elu pärast kapitalismi. Küsivad ja vastavad näitlejad, kirjanikud, kunstnikud, filmitegijad Eestist ja mujalt

  4. KARAKTERISTIK KIMIA AIR HUJAN SAAT KEBAKARAN HUTAN DI PROPINSI KALIMANTAN BARAT DAN SUMATERA SELATAN

    Directory of Open Access Journals (Sweden)

    Sheila Dewi Ayu Kusumaningtyas

    2014-08-01

    Full Text Available Permasalahan kebakaran hutan di berbagai propinsi di Indonesia terutama di Kalimantan Barat dan Sumatera Selatan mulai marak seiring dengan meningkatnya laju penebangan hutan serta tingginya tekanan penduduk akan pemenuhan kebutuhan hidup melalui sumber daya kawasan hutan. Kebakaran hutan berpengaruh terhadap lingkungan berupa penurunan kualitas udara. Untuk mengetahui dampak kebakaran hutan terhadap karakterisitik kimia air hujan dan kondisi partikulat di Pontianak dan Palembang dilakukan analisa parameter anion, kation, dan pH air hujan serta Suspended Particulate Matter (SPM selama periode 2002 hingga 2008. Data kimia air hujan dan SPM diperoleh dari pengamatan Stasiun Meteorologi Supadio Pontianak dan Stasiun Klimatologi Kenten, Palembang, sedangkan analisanya dilakukan di BMKG Pusat menggunakan Kromatografi Ion. Untuk mengetahui jumlah kebakaran hutan digunakan parameter titik api dari Satelit Terra dan Aqua MODIS yang dikumpulkan dan dikelola oleh Stasiun Bumi Satelit NOAA, Kementerian Kehutanan. Dari hasil kajian diketahui bahwa kenaikan jumlah titik api baik di daerah Kalimantan Barat dan Sumatera Selatan diiringi oleh kenaikan konsentrasi deposisi asam dan SPM beberapa saat kemudian. Baik di Pontianak dan Palembang telah terjadi hujan asam dengan presentasi kejadian berturut-turut adalah 61,1 % dan 71,8 %. Komposisi kimia penyusun air hujan di Pontianak dan Palembang baik pada saat titik api tinggi ataupun rendah didominasi oleh unsur Cl-, NH4+, Ca2+, dan Na+. Tingginya konsentrasi NH4+, Ca2+, dan Na+ selama kurun waktu 2002 hingga 2008 berperan sebagai faktor penetral keasaman air hujan sehingga kecenderungan pH mengalami kenaikan. Baik di Pontianak dan Palembang, kenaikan titik api diiringi dengan kenaikan konsentrasi SPM dengan koefisien korelasi masing-masing 0,836 dan 0,678.   Forest fire which occurs in many provinces in Indonesia especially in West Kalimantan and South Sumatera increases along with the high and rapid

  5. Mis teoksil, härrad saadikud? / Igor Gräzin

    Index Scriptorium Estoniae

    Gräzin, Igor, 1952-

    2007-01-01

    Parlamendiliige meenutab, et hetkel, kui Riigikogu oli valmis arutama riigile üliolulist küsimust Eesti merepiiri õigest kulgemisest, tõstatati parlamendis saadikute kuluhüvitiste teema. Igor Gräzin kinnitab, et Riigikogu teeb ka edaspidi neid otsuseid, mis ei otsi lühiajalist populaarsust, vaid seisavad Eesti riikluse ja vabaduse kaitsel

  6. Strong asymmetry of hemispheric climates during MIS-13 inferred from correlating China loess and Antarctica ice records

    Directory of Open Access Journals (Sweden)

    Z. T. Guo

    2009-02-01

    Full Text Available We correlate the China loess and Antarctica ice records to address the inter-hemispheric climate link over the past 800 ka. The results show a broad coupling between Asian and Antarctic climates at the glacial-interglacial scale. However, a number of decoupled aspects are revealed, among which marine isotope stage (MIS 13 exhibits a strong anomaly compared with the other interglacials. It is characterized by unusually positive benthic oxygen (δ18O and carbon isotope (δ13C values in the world oceans, cooler Antarctic temperature, lower summer sea surface temperature in the South Atlantic, lower CO2 and CH4 concentrations, but by extremely strong Asian, Indian and African summer monsoons, weakest Asian winter monsoon, and lowest Asian dust and iron fluxes. Pervasive warm conditions were also evidenced by the records from northern high-latitude regions. These consistently indicate a warmer Northern Hemisphere and a cooler Southern Hemisphere, and hence a strong asymmetry of hemispheric climates during MIS-13. Similar anomalies of lesser extents also occurred during MIS-11 and MIS-5e. Thus, MIS-13 provides a case that the Northern Hemisphere experienced a substantial warming under relatively low concentrations of greenhouse gases. It suggests that the global climate system possesses a natural variability that is not predictable from the simple response of northern summer insolation and atmospheric CO2 changes. During MIS-13, both hemispheres responded in different ways leading to anomalous continental, marine and atmospheric conditions at the global scale. The correlations also suggest that the marine δ18O record is not always a reliable indicator of the northern ice-volume changes, and that the asymmetry of hemispheric climates is one of the prominent factors controlling the strength of Asian, Indian and African monsoon circulations, most likely through modulating the position of

  7. MIS gas sensors based on porous silicon with Pd and WO{sub 3}/Pd electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Solntsev, V.S. [Institute of Semiconductor Physics, National Academy of Science of Ukraine, 03028, Kiev (Ukraine); Gorbanyuk, T.I., E-mail: tatyanagor@mail.r [Institute of Semiconductor Physics, National Academy of Science of Ukraine, 03028, Kiev (Ukraine); Litovchenko, V.G.; Evtukh, A.A. [Institute of Semiconductor Physics, National Academy of Science of Ukraine, 03028, Kiev (Ukraine)

    2009-09-30

    Pd and WO{sub 3}/Pd gate metal-oxide-semiconductor (MIS) gas sensitive structures based on porous silicon layers are studied by the high frequency C(V) method. The chemical compositions of composite WO{sub 3}/Pd electrodes are characterized by secondary-ion mass spectrometry (SIMS). The atomic force microscopy (AFM) was used for morphologic studies of WO{sub 3}/Pd films. As shown in the experiments, WO{sub 3}/Pd structures are more sensitive and selective to the adsorption of hydrogen sulphide compared to Pd gate. The analyses of kinetic characteristics allow us to determine the response and characteristic times for these structures. The response time of MIS-structures with thin composite WO{sub 3}/Pd electrodes (the thickness of Pd is about 50 nm with WO{sub 3} clusters on its surface) is slower compared to the structures with Pd electrodes. Slower sensor responses of WO{sub 3}-based gas sensors may be associated with different mechanism of gas sensitivity of given structures. The enhanced sensitivity and selectivity to H{sub 2}S action of WO{sub 3}/Pd MIS-structures can also be explained by the chemical reaction that occurs at the catalytic active surface of gate electrodes. The possible mechanisms of enhanced sensitivity and selectivity to H{sub 2}S adsorption of MIS gas sensors with WO{sub 3}/Pd composite gate electrodes compared to pure Pd have been analyzed.

  8. MIS photodetectors on intrinsic semiconductors for thermal infrared imagery - A design aid for focal plane matrices

    Science.gov (United States)

    Farre, J.

    1980-12-01

    The physical mechanisms determining the operational behavior of an MIS photodetector for thermal infrared imagery based on a two-dimensional matrix of intrinsic semiconductors constituting a charge injection device are examined. The general principles of a thermal infrared imagery system composed of radiation source, atmosphere, sensor system with entrance optics, detector and environment, and data processing means are introduced, and the parameters of the system as a whole influencing detector characteristics are indicated. The properties of an ideal and a real MIS photodetector are discussed, with attention given to the physical properties of narrow bandgap materials such as InSb, operational properties in the dynamic regime, the carrier tunneling component and experimentally observed instability phenomena. The matrix organization of MIS photodetectors is then considered, with particular attention given to a simple model of charge transfer between two electrodes and the two principal reading mechanisms: charge injection and the floating potential method.

  9. DNA methylation in Cosmc promoter region and aberrantly glycosylated IgA1 associated with pediatric IgA nephropathy.

    Directory of Open Access Journals (Sweden)

    Qiang Sun

    Full Text Available IgA nephropathy (IgAN is one of the most common glomerular diseases leading to end-stage renal failure. Elevation of aberrantly glycosylated IgA1 is a key feature of it. The expression of the specific molecular chaperone of core1ß1, 3galactosyl transferase (Cosmc is known to be reduced in IgAN. We aimed to investigate whether the methylation of CpG islands of Cosmc gene promoter region could act as a possible mechanism responsible for down-regulation of Cosmc and related higher secretion of aberrantly glycosylated IgA1in lymphocytes from children with IgA nephropathy. Three groups were included: IgAN children (n = 26, other renal diseases (n = 11 and healthy children (n = 13. B-lymphocytes were isolated and cultured, treated or not with IL-4 or 5-Aza-2'-deoxycytidine (AZA. The levels of DNA methylation of Cosmc promotor region were not significantly different between the lymphocytes of the three children populations (P = 0.113, but there were significant differences between IgAN lymphocytes and lymphocytes of the other two children populations after IL-4 (P<0.0001 or AZA (P<0.0001. Cosmc mRNA expression was low in IgAN lymphocytes compared to the other two groups (P<0.0001. The level of aberrantly glycosylated IgA1 was markedly higher in IgAN group compared to the other groups (P<0.0001. After treatment with IL-4, the levels of Cosmc DNA methylation and aberrantly glycosylated IgA1 in IgAN lymphocytes were remarkably higher than the other two groups (P<0.0001 with more markedly decreased Cosmc mRNA content (P<0.0001. After treatment with AZA, the levels in IgAN lymphocytes were decreased, but was still remarkably higher than the other two groups (P<0.0001, while Cosmc mRNA content in IgAN lymphocytes were more markedly increased than the other two groups (P<0.0001. The alteration of DNA methylation by IL-4 or AZA specifically correlates in IgAN lymphocytes with alterations in Cosmc mRNA expression and with the level of aberrantly glycosylated

  10. Speleothem records of changes in the South American Summer Monsoon during MIS stages 5 and 6

    Science.gov (United States)

    Burns, S. J.; Kanner, L.; Cheng, H.; Edwards, R.

    2011-12-01

    Little information exists about the behavior of the South American Summer Monsoon prior to the Last Glacial Period. Speleothems from the Peruvian Altiplano are one possible archive of SASM intensity because oxygen isotopes of rainfall on the Altiplano are primarily controlled by the intensity of rainfall in upstream moisture source region, the Amazon Basin. Here, we present results from a two speleothems collected from Gruta de Huagapo, a cave in the central Peruvian Altiplano (12°S, 76°W, ~3800m elevation). The samples grew from approximately 115-125 ky BP and from 136-168 ky BP, spanning time periods equivalent to much of MIS stage 5e and the transition into MIS 5d and MIS 6. Chronologies were determined by U-Th dating techniques and the dates are in stratigraphic with analytical errors Titicaca (Fritz et al, 2007). At present we have isotopic data from only the youngest 10 ky of the older sample. The values are generally more depleted, with most between -16% and -17%, suggesting an intensified SASM during MIS 6 as compared to 5e. A rapid increase in δ18O occurs at ~136 ky BP. Overall the trends in the data parallel major changes in δD from EPICA, but appear to lead the Antarctic time series by ~2 ky.

  11. Näitus, mis paneb külastajad minestama / Tiina Ansip

    Index Scriptorium Estoniae

    Ansip, Tiina

    2007-01-01

    Vt. ka Linnaleht : Pärnu, Linnaleht : Tartu 3. aug., lk. B4, Linnaleht : na russkom jazõke 15. aug., lk. 11. Tallinna Matkamajas nähtav vahakabineti Panoptikon anatoomianäitus pole mõeldud nõrganärvilistele - liigagi tõetruud vahakujud, mis kujutavad eri eas looteid, aborti ning suguhaigustest kahjustatud genitaale, on Eestiski inimesi minestama pannud

  12. 49 CFR Appendix H to Part 40 - DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form

    Science.gov (United States)

    2010-10-01

    ..., App. H Appendix H to Part 40—DOT Drug and Alcohol Testing Management Information System (MIS) Data... 49 Transportation 1 2010-10-01 2010-10-01 false DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form H Appendix H to Part 40 Transportation Office of the Secretary...

  13. Muon Identification performance: hadron mis-Id measurements and RPC Muon selections

    CERN Document Server

    CMS Collaboration

    2014-01-01

    Pion, kaon, proton mis-identification probabilities as muons have been measured for different Muon ID algorithms. Results from two independent analyses are presented. The performance of a new muon ID algorithm based on matching of inner tracks with hits in muon RPC chambers is also presented.

  14. PC operated acoustic transient spectroscopy of deep levels in MIS structures

    International Nuclear Information System (INIS)

    Bury, P.; Jamnicky, I.

    1996-01-01

    A new version of acoustic deep-level transient spectroscopy is presented to study the traps at the insulator-semiconductor interface. The acoustic deep-level transient spectroscopy uses an acoustoelectric response signal produced by the MIS structure interface when a longitudinal acoustic wave propagates through a structure. The acoustoelectric response signal is extremely sensitive to external conditions of the structure and reflects any changes in the charge distribution, connected also with charged traps. In comparison with previous version of acoustic deep-level transient spectroscopy that closely coincides with the principle of the original deep-level transient spectroscopy technique, the present technique is based on the computer-evaluated isothermal transients and represents an improved, more efficient and time saving technique. Many tests on the software used for calculation as well as on experimental setup have been performed. The improved acoustic deep-level transient spectroscopy method has been applied for the Si(p) MIS structures. The deep-level parameters as activation energy and capture cross-section have been determined. (authors)

  15. Gluten sensitivity in patients with IgA nephropathy.

    Science.gov (United States)

    Smerud, Hilde Kloster; Fellström, Bengt; Hällgren, Roger; Osagie, Sonia; Venge, Per; Kristjánsson, Gudjón

    2009-08-01

    Coeliac disease is more frequent in IgA nephropathy (IgAN) patients compared to the healthy population. Several hypotheses postulate that food antigens like gluten may be involved in the onset of IgAN. In this study, we used a recently developed mucosal patch technique to evaluate the rectal mucosal inflammatory reaction to gluten in patients with IgAN (n = 27) compared to healthy subjects (n = 18). The rectal mucosal production of nitric oxide (NO) and release of myeloperoxidase (MPO) and eosinophil cationic protein (ECP) were measured. Serum samples were analysed for IgA and IgG antigliadin antibodies (AGA), IgA antibodies against tissue transglutaminase and IgA endomysium antibodies. Gluten reactivity, defined as increase in MPO and/or NO after gluten exposure, was observed in 8 of 27 IgAN patients. The prevalence of HLA-DQ2 and DQ8 was not increased among gluten-sensitive patients, and the total prevalence among IgAN patients was the same as for the normal population. An elevated serum IgA AGA response was seen in 9 of 27 IgAN patients. The increase in IgA AGA did not correlate with the gluten sensitivity as measured by NO and/or MPO. A specific serum IgG AGA response was seen in one patient only. Antibodies against tissue transglutaminase and endomysium were not observed. It is concluded that approximately one-third of our IgAN patients have a rectal mucosal sensitivity to gluten, but without signs of coeliac disease, and we hypothesize that such sub-clinical inflammation to gluten might be involved in the pathogenesis of IgAN in a subgroup of patients.

  16. [The clinical study of IgA nephropathy with severe chronic periodontitis and aggressive periodontitis].

    Science.gov (United States)

    Cao, Y L; Qiao, M; Xu, Z H; Zou, G M; Ma, L L; Li, W G; Xu, B H

    2016-01-05

    To explore the clinical characteristics of IgA nephropathy (IgAN) with severe chronic periodontitis and aggressive periodontitis. A total of 436 hospitalized patients who underwent renal needle biopsy in the department of nephrology of China-Japan Friendship Hospital from November 2013 to December 2014 were recruited in the study and blindly had periodontal examination. The patients were divided into IgAN group and non-IgAN group according to the renal pathology. The patients with IgAN were further categorized as non-periodontitis, chronic periodontitis and aggressive peridontitis group by Haas classification. The chronic periodontitis group was continually divided into mild, moderate and severe periodontitis group. The levels of interleukin (IL)-1β and IL-6 in gingival crevicular fluid were analyzed by enzyme-linked immunosorbent assays. The prevalence of periodontitis in the study was 88.3% (385/436). The prevalence of chronic periodontitis and aggressive periodontitis were higher in patients with IgAN than those with non-IgAN (Pchronic periodontitis was correlated with pathologic grading of IgAN (r=0.48, Pperiodontitis, those with severe chronic and aggressive periodontitis had more severe pathology, more frequent recurrent gross hematuria, higher levels of 24 h proteinuria, serum triglyceride and uric acid, higher periodontal probing depth and clinical attatchment level, as well as higer levels of IL-1β and IL-6, but had lower creatinine clearance rate (all Pchronic and aggressive periodontitis was higher in patients with IgAN. Chronic periodontitis is correlated with the onset and development of IgAN. Patients with IgAN have worse condition with the aggravation of periodontitis.

  17. MIS416 Enhances Therapeutic Functions of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Experimental Colitis by Modulating Systemic Immune Milieu

    Directory of Open Access Journals (Sweden)

    Byung-Chul Lee

    2018-05-01

    Full Text Available Human adult stem cells, including umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs, have recently been considered a promising alternative treatment for inflammatory bowel disease (IBD due to their unique immunomodulatory properties and ability to promote tissue regeneration. However, despite many years of research and pre-clinical studies, results from clinical trials using these cells have been diverse and conflicting. This discrepancy is caused by several factors, such as poor engraftment, low survival rate, and donor-dependent variation of the cells. Enhancement of consistency and efficacy of MSCs remains a challenge for the feasibility of cell-based therapy. In this study, we investigated whether administration of MIS416, a novel microparticle that activates NOD2 and TLR9 signaling, could enhance the therapeutic efficacy of hUCB-MSCs against Crohn’s disease, using dextran sulfate sodium (DSS-induced colitis model. Colitis was experimentally induced in mice by using 3% DSS, and mice were administered a retro-orbital injection of MIS416 and subsequent intraperitoneal injection of hUCB-MSCs. Mice were examined grossly, and blood, spleen, and colon tissues were subsequently collected for further ex vivo analyses. To explore the effects of MIS416 on the therapeutic process, hUCB-MSCs and primary isolated immune cells were cultured with MIS416, and in vitro assays were performed. Compared to the single administration of hUCB-MSCs, co-administration with MIS416 improved the therapeutic efficiency of the stem cells by significantly alleviating the symptoms of IBD. Interestingly, MIS416 did not exert any direct effect on the immunomodulatory capacity of hUCB-MSCs. Instead, systemically injected MIS416 altered the immune milieu in the colon which caused hUCB-MSCs to be more readily recruited toward the lesion site and to suppress inflammation more efficiently. In addition, considerable numbers of regulatory immune cells were stimulated

  18. "Sa, haavapuu, kesköösel valendad..." : [luuletused] / Paul Celan ; saksa k. tlk. [ja saatesõna]: Ain Kaalep

    Index Scriptorium Estoniae

    Celan, Paul, pseud., 1920-1970

    2001-01-01

    Autorist lk. 49-50. Sisu: "Sa, haavapuu, kesköösel valendad..." ; Mälestus Prantsusmaast ; Aastad sinust minuni ; Surmafuuga ; Aja silm ; Kõnevõre ; Silm, lahtine ; Zürich, "Toonekure" kohvik : Nelly Sachsile ; Psalm ; "Niitpäikesed..." ; "Maovankris, mööda..." ; "Maastik urnidega..." ; Prahas ; "Kõmin: see on..." ; "Üks hambajälg eikuskilpool..." ; "Kahinais, otsekui meie alguses..." ; Teine ; "Teie oma..." ; "See, mis meid..." ; "Lõika palvekäsi..." ; "Ma kuulen, et kirves lõi õitsema..." ; "Leht, mille puu küljest..."

  19. The analysis of Last Interglacial (MIS 5e) relative sea-level indicators: Reconstructing sea-level in a warmer world

    NARCIS (Netherlands)

    Rovere, A.; Raymo, M.E.; Vacchi, M.; Lorscheid, T; Stocchi, P.; Gómez-Pujolf, L.; Harris, D.L.; Casella, E.; O'Leary, M.J.; Hearty, P.J.

    2016-01-01

    The Last Interglacial (MIS 5e, 128–116 ka) is among the most studied past periods in Earth's history. The climate at that time was warmer than today, primarily due to different orbital conditions, with smaller ice sheets and higher sea-level. Field evidence for MIS 5e sea-level was reported from

  20. Mid-depth South Atlantic Ocean circulation and chemical stratification during MIS-10 to 12: implications for atmospheric CO2

    Directory of Open Access Journals (Sweden)

    M. A. Maslin

    2008-12-01

    Full Text Available A detailed record of benthic foraminifera carbon isotopes from the intermediate-depth South East Atlantic margin shows little glacial-interglacial variability between MIS-12 to MIS-10, suggesting that Northern Atlantic deepwaters consistently penetrated to at least 30° S. Millennial-scale increases in either the mass or flux of northern-sourced deepwaters over the core site occurred alongside reductions in Lower North Atlantic Deep Water recorded in North Atlantic sediment cores and show that the lower and intermediate limb of the Atlantic deepwater convective cell oscillated in anti-phase during previous glacial periods. In addition, a 500 yr resolution record of the Cape Basin intermediate-deep δ13C gradient shows that a reduction in deep Southern Ocean ventilation at the end of MIS-11 was consistent with a modelled CO2 drawdown of ~21–30 ppm. Further increases in the Southern Ocean chemical divide during the transition into MIS-10 were completed before minimum CO2 levels were reached, suggesting that other mechanisms such as alkalinity changes were responsible for the remaining ~45 ppm drawdown.

  1. Measurement of the Mis-identification Probability of τ Leptons from Hadronic Jets and from Electrons

    CERN Document Server

    The ATLAS collaboration

    2011-01-01

    Measurements of the mis-identification probability of QCD jets and electrons as hadronically decaying τ leptons using tag-and-probe methods are described. The analyses are based on 35pb−1 of proton-proton collision data, taken by the ATLAS experiment at a center-of-mass energy of sqrt(s) = 7 TeV. The mis-identification probabilities range between 10% and 0.1% for QCD jets, and about (1 − 2)% for electrons. They depend on the identification algorithm chosen, the pT and the number of prongs of the τ candidate, and on the amount of pile up present in the event.

  2. Noise characterization of enhancement-mode AlGaN graded barrier MIS-HEMT devices

    Science.gov (United States)

    Mohanbabu, A.; Saravana Kumar, R.; Mohankumar, N.

    2017-12-01

    This paper reports a systematic theoretical study on the microwave noise performance of graded AlGaN/GaN metal-insulator semiconductor high-electron mobility transistors (MIS-HEMTs) built on an Al2O3 substrate. The HfAlOx/AlGaN/GaN MIS-HEMT devices designed for this study show an outstanding small signal analog/RF and noise performance. The results on 1 μm gate length device show an enhancement mode operation with threshold voltage, VT = + 5.3 V, low drain leakage current, Ids,LL in the order of 1 × 10-9 A/mm along with high current gain cut-off frequency, fT of 17 GHz and maximum oscillation frequency fmax of 47 GHz at Vds = 10 V. The device Isbnd V and low-frequency noise estimation of the gate and drain noise spectral density and their correlation are evaluated using a Green's function method under different biasing conditions. The devices show a minimum noise figure (NFmin) of 1.053 dB in combination with equivalent noise resistance (Rn) of 23 Ω at 17 GHz, at Vgs = 6 V and Vds = 5 V which is relatively low and is suitable for broad-band low-noise amplifiers. This study shows that the graded AlGaN MIS-HEMT with HfAlOX gate insulator is appropriate for application requiring high-power and low-noise.

  3. Extracapillary proliferation in IgA nephropathy; recent findings and new ideas.

    Science.gov (United States)

    Nasri, Hamid; Mubarak, Muhammed

    2015-01-01

    IgA nephropathy (IgAN) is an autoimmune disorder and is the most common form of primary glomerulonephritis (GN) worldwide. Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO) and Web of Science have been searched. It is a slowly progressing disorder that leads to end-stage renal disease (ESRD) in up to 50% of the patients within 25 years of the onset of the disease. IgAN is defined by predominant IgA deposition in the mesangial area on immunofluorescence (IF) microscopy. Its histology varies from mild focal segmental proliferation of mesangial cells to severe diffuse global proliferation with extracapillary proliferation (crescent formation). The Oxford classification, designed in 2009, is a new classification for the evaluation of morphologic lesions of IgAN. This classification, containing four pathology variables, was found to have prognostic implications. The variables included are mesangial hypercellularity (M), endocapillary proliferation (E), segmental glomerulosclerosis (S) and the proportion of interstitial fibrosis and tubular atrophy (T). However, crescents were not included in the Oxford classification. In this mini-review, we describe the recent publications about the significance of extracapillary proliferation in IgAN and we conclude that, there is much controversy about the role of extracapillary proliferation as a significant prognostic factor in IgAN. Hence, it is important to re-consider crescents in IgAN patients. Therefore, we suggest further investigations on this aspect of IgAN disease.

  4. Unexpected weak seasonal climate in the western Mediterranean region during MIS 31, a high-insolation forced interglacial

    Science.gov (United States)

    Oliveira, Dulce; Sánchez Goñi, Maria Fernanda; Naughton, Filipa; Polanco-Martínez, J. M.; Jimenez-Espejo, Francisco J.; Grimalt, Joan O.; Martrat, Belen; Voelker, Antje H. L.; Trigo, Ricardo; Hodell, David; Abrantes, Fátima; Desprat, Stéphanie

    2017-04-01

    Marine Isotope Stage 31 (MIS 31) is an important analogue for ongoing and projected global warming, yet key questions remain about the regional signature of its extreme orbital forcing and intra-interglacial variability. Based on a new direct land-sea comparison in SW Iberian margin IODP Site U1385 we examine the climatic variability between 1100 and 1050 ka including the ;super interglacial; MIS 31, a period dominated by the 41-ky obliquity periodicity. Pollen and biomarker analyses at centennial-scale-resolution provide new insights into the regional vegetation, precipitation regime and atmospheric and oceanic temperature variability on orbital and suborbital timescales. Our study reveals that atmospheric and SST warmth during MIS 31 was not exceptional in this region highly sensitive to precession. Unexpectedly, this warm stage stands out as a prolonged interval of a temperate and humid climate regime with reduced seasonality, despite the high insolation (precession minima values) forcing. We find that the dominant forcing on the long-term temperate forest development was obliquity, which may have induced a decrease in summer dryness and associated reduction in seasonal precipitation contrast. Moreover, this study provides the first evidence for persistent atmospheric millennial-scale variability during this interval with multiple forest decline events reflecting repeated cooling and drying episodes in SW Iberia. Our direct land-sea comparison shows that the expression of the suborbital cooling events on SW Iberian ecosystems is modulated by the predominance of high or low-latitude forcing depending on the glacial/interglacial baseline climate states. Severe dryness and air-sea cooling is detected under the larger ice volume during glacial MIS 32 and MIS 30. The extreme episodes, which in their climatic imprint are similar to the Heinrich events, are likely related to northern latitude ice-sheet instability and a disruption of the Atlantic Meridional Overturning

  5. Relative sea-level changes and glacio-isostatic adjustment on the Magdalen Islands archipelago (Atlantic Canada) from MIS 5 to the late Holocene

    Science.gov (United States)

    Rémillard, Audrey M.; St-Onge, Guillaume; Bernatchez, Pascal; Hétu, Bernard; Buylaert, Jan-Pieter; Murray, Andrew S.; Lajeunesse, Patrick

    2017-09-01

    The Magdalen Islands (Québec, Canada) in the centre of the Gulf of St. Lawrence are located in a strategic position for providing an overview of the relative sea-level (RSL) history of the Maritime Provinces of eastern Canada. Although data are available for the coastal terrestrial areas of the Maritimes, data from the Gulf are very scarce and both the RSL and glacio-isostatic adjustment (GIA) models extrapolate for this central region. This study provides new stratigraphic and chronological data from four outcrops and two coring sites on the Magdalen Islands. In addition to the five samples used mainly for age control purposes, nine new luminescence ages are presented. With these new data added to the available literature, a new RSL curve is reconstructed for the LGM to the late Holocene period and a partial curve is proposed for the interval between the late MIS 4 to the MIS 3. Data also indicate a few insights for the MIS 5 period. Results reveal that for the LGM to the late Holocene, the curve corresponds to the J-shaped curve scenario recognized in the literature. The RSL changes during this period are the result of glacio-isostatic rebound, migration and collapse of the peripheral forebulge, and eustatic sea-level changes. For the LGM to the early Holocene, glacio-isostatic depression curves displaying a few local differences are also proposed. For the late Holocene, the data constrain the curve between two types of indicators, i.e. marine and terrestrial, and indicate that the RSL has risen at least 3 m during the last two millennia. Sediments dated to the MIS 5 and the interval between the late MIS 4 and the MIS 3 illustrate that the GIA following the LGM also occurred for the MIS 5 interglacial and the MIS 3 interstadial. Finally, recent GIA models are discussed in light of the results of this paper.

  6. Probabilistic model of random uncertainties in structural dynamics for mis-tuned bladed disks; Modele probabiliste des incertitudes en dynamique des structures pour le desaccordage des roues aubagees

    Energy Technology Data Exchange (ETDEWEB)

    Capiez-Lernout, E.; Soize, Ch. [Universite de Marne la Vallee, Lab. de Mecanique, 77 (France)

    2003-10-01

    The mis-tuning of blades is frequently the cause of spatial localizations for the dynamic forced response in turbomachinery industry. The random character of mis-tuning requires the construction of probabilistic models of random uncertainties. A usual parametric probabilistic description considers the mis-tuning through the Young modulus of each blade. This model consists in mis-tuning blade eigenfrequencies, assuming the blade modal shapes unchanged. Recently a new approach known as a non-parametric model of random uncertainties has been introduced for modelling random uncertainties in elasto-dynamics. This paper proposes the construction of a non-parametric model which is coherent with all the uncertainties which characterize mis-tuning. As mis-tuning is a phenomenon which is independent from one blade to another one, the structure is considered as an assemblage of substructures. The mean reduced matrix model required by the non-parametric approach is thus constructed by dynamic sub-structuring. A comparative approach is also needed to study the influence of the non-parametric approach for a usual parametric model adapted to mis-tuning. A numerical example is presented. (authors)

  7. Univariate and multiple linear regression analyses for 23 single nucleotide polymorphisms in 14 genes predisposing to chronic glomerular diseases and IgA nephropathy in Han Chinese.

    Science.gov (United States)

    Wang, Hui; Sui, Weiguo; Xue, Wen; Wu, Junyong; Chen, Jiejing; Dai, Yong

    2014-09-01

    Immunoglobulin A nephropathy (IgAN) is a complex trait regulated by the interaction among multiple physiologic regulatory systems and probably involving numerous genes, which leads to inconsistent findings in genetic studies. One possibility of failure to replicate some single-locus results is that the underlying genetics of IgAN nephropathy is based on multiple genes with minor effects. To learn the association between 23 single nucleotide polymorphisms (SNPs) in 14 genes predisposing to chronic glomerular diseases and IgAN in Han males, the 23 SNPs genotypes of 21 Han males were detected and analyzed with a BaiO gene chip, and their associations were analyzed with univariate analysis and multiple linear regression analysis. Analysis showed that CTLA4 rs231726 and CR2 rs1048971 revealed a significant association with IgAN. These findings support the multi-gene nature of the etiology of IgAN and propose a potential gene-gene interactive model for future studies.

  8. Adolescent Alcohol Consumption in Romania: A Blueprint for Measuring Alcohol (mis)Use

    NARCIS (Netherlands)

    van Hoof, Joris Jasper; Moll, Marit

    2012-01-01

    In order to address the issues of adolescent alcohol (mis)use in Romanian cities and to develop local alcohol prevention policies comprised of interventions aimed at reducing alcohol consumption and alcohol related problems, information on the prevalence of alcohol use and relevant related topics is

  9. Climate and hydrology of the last interglaciation (MIS 5) in Owens Basin, California: Isotopic and geochemical evidence from core OL-92

    Science.gov (United States)

    Li, H.-C.; Bischoff, J.L.; Ku, T.-L.; Zhu, Z.-Y.

    2004-01-01

    ??18O, ??13C, total organic carbon, total inorganic carbon, and acid-leachable Li, Mg and Sr concentrations on 443 samples from 32 to 83 m depth in Owens Lake core OL-92 were analyzed to study the climatic and hydrological conditions between 60 and 155 ka with a resolution of ???200 a. The multi-proxy data show that Owens Lake overflowed during wet/cold conditions of marine isotope stages (MIS) 4, 5b and 6, and was closed during the dry/warm conditions of MIS 5a, c and e. The lake partially overflowed during MIS 5d. Our age model places the MIS 4/5 boundary at ca 72.5 ka and the MIS 5/6 boundary (Termination II) at ca 140 ka, agreeing with the Devils Hole chronology. The diametrical precipitation intensities between the Great Basin (cold/wet) and eastern China (cold/dry) on Milankovitch time scales imply a climatic teleconnection across the Pacific. It also probably reflects the effect of high-latitude ice sheets on the southward shifts of both the summer monsoon frontal zone in eastern Asia and the polar jet stream in western North America during glacial periods. ?? 2003 Elsevier Ltd. All rights reserved.

  10. MIS 5e sea levels and `superstorms': what the integration of field data and modelling can tell us?

    Science.gov (United States)

    Rovere, A.; Raymo, M. E.; O'Leary, M.; Stocchi, P.; Vacchi, M.; Lorscheid, T.; Harris, D. L.; Casella, E.; Nandasena, N. A. K.; Sandstrom, R. M.; D'Andrea, W. J.; Dyer, B.

    2016-12-01

    The Last Interglacial (MIS 5e, 128-116 ka) is among the most studied past periods in Earth's history. The climate at that time was warmer than today, primarily due to different orbital conditions, with smaller ice sheets and higher sea level. Understanding the climate system, and in particular sea level, during MIS 5e is essential to understand the behavior of ice sheets in a warmer world. Two questions in particular remain unsolved: was there a meltwater pulse towards the end of the interglacial? Was the same period characterized by superstorms? Thousands of studies spanning more than a century report information on MIS 5e RSL indicators. Despite the large quantity of field data available, the two questions formulated above remain unanswered. This is due to different reasons. In first instance, relative sea-level (RSL) indicators and field interpretations may carry large uncertainties. Second, processes such as tectonics are difficult to isolate and quantify independently. In this presentation, we will describe the strategies that can be adopted to minimize the uncertainties associated with paleo RSL calculations, and we show the limits of `tectonic stability' assumptions based on the position of MIS 5e shorelines. We then show that the combination of high-resolution topographic methods (e.g. GPS, photogrammetry from UAVs and detailed bathymetry) with scenarios dictated by GIA and coastal hydrodynamic models is essential to gather insights not only on the indicative meaning of RSL indicators, but also on the hypothesis that the last period of MIS 5e was characterized by `superstorms' (as defined by Hansen, J. et al. Atmos. Chem. Phys. Discuss. 15, 2015).

  11. Plasma oxidative stress level of IgA nephropathy in children and the effect of early intervention with angiotensin-converting enzyme inhibitors.

    Science.gov (United States)

    Pei, Yuxin; Xu, Yuanyuan; Ruan, Jingwei; Rong, Liping; Jiang, Mengjie; Mo, Ying; Jiang, Xiaoyun

    2016-01-01

    The purpose of this study was to investigate the change of the plasma oxidative stress level in children with IgA nephropathy (IgAN) and analyze its relativity to the clinical and pathological classification. To discuss the early effects of angiotensin-converting enzyme inhibitors (ACEIs) on the plasma oxidative stress level in children with IgA nephropathy. Thirty-eight children with IgAN were divided into groups according to their clinical features, pathologic grades, and treatments. Twenty healthy children were included in the control group. The plasma level of advanced oxidation protein products (AOPPs), malonaldehyde (MDA), and superoxide dismutase (SOD) were detected. The plasma level of oxidative stress was significantly increased in the IgAN group, including a higher plasma level of AOPP and MDA and a lower plasma level of SOD. After treatment, the plasma level of oxidative stress was significantly decreased in the ACEI group. The children with IgAN had an increase in the plasma level of oxidative stress, expressed as an increased plasma level of AOPP and MDA and a decreased plasma level of SOD. Oxidative stress was associated with the progression of IgAN in children. Early treatment with ACEI therapy can significantly reduce the plasma level of oxidative stress in children with IgAN. © The Author(s) 2016.

  12. Coping with unobservable and mis-classified states in capture-recapture studies

    Directory of Open Access Journals (Sweden)

    Kendall, W. L.

    2004-01-01

    Full Text Available Multistate mark-recapture methods provide an excellent conceptual framework for considering estimation in studies of marked animals. Traditional methods include the assumptions that (1 each state an animal occupies is observable, and (2 state is assigned correctly at each point in time. Failure of either of these assumptions can lead to biased estimates of demographic parameters. I review design and analysis options for minimizing or eliminating these biases. Unobservable states can be adjusted for by including them in the state space of the statistical model, with zero capture probability, and incorporating the robust design, or observing animals in the unobservable state through telemetry, tag recoveries, or incidental observations. Mis¿classification can be adjusted for by auxiliary data or incorporating the robust design, in order to estimate the probability of detecting the state an animal occupies. For both unobservable and mis-classified states, the key feature of the robust design is the assumption that the state of the animal is static for at least two sampling occasions

  13. Fabrication of three-dimensional MIS nano-capacitor based on nano-imprinted single crystal silicon nanowire arrays

    KAUST Repository

    Zhai, Yujia

    2012-11-26

    We report fabrication of single crystalline silicon nanowire based-three-dimensional MIS nano-capacitors for potential analog and mixed signal applications. The array of nanowires is patterned by Step and Flash Imprint Lithography (S-FIL). Deep silicon etching (DSE) is used to form the nanowires with high aspect ratio, increase the electrode area and thus significantly enhance the capacitance. High-! dielectric is deposited by highly conformal atomic layer deposition (ALD) Al2O3 over the Si nanowires, and sputtered metal TaN serves as the electrode. Electrical measurements of fabricated capacitors show the expected increase of capacitance with greater nanowire height and decreasing dielectric thickness, consistent with calculations. Leakage current and time-dependent dielectric breakdown (TDDB) are also measured and compared with planar MIS capacitors. In view of greater interest in 3D transistor architectures, such as FinFETs, 3D high density MIS capacitors offer an attractive device technology for analog and mixed signal applications. - See more at: http://www.eurekaselect.com/105099/article#sthash.EzeJxk6j.dpuf

  14. Fabrication of three-dimensional MIS nano-capacitor based on nano-imprinted single crystal silicon nanowire arrays

    KAUST Repository

    Zhai, Yujia; Palard, Marylene; Mathew, Leo; Hussain, Muhammad Mustafa; Willson, Grant Grant; Tutuc, Emanuel; Banerjee, Sanjay Kumar

    2012-01-01

    We report fabrication of single crystalline silicon nanowire based-three-dimensional MIS nano-capacitors for potential analog and mixed signal applications. The array of nanowires is patterned by Step and Flash Imprint Lithography (S-FIL). Deep silicon etching (DSE) is used to form the nanowires with high aspect ratio, increase the electrode area and thus significantly enhance the capacitance. High-! dielectric is deposited by highly conformal atomic layer deposition (ALD) Al2O3 over the Si nanowires, and sputtered metal TaN serves as the electrode. Electrical measurements of fabricated capacitors show the expected increase of capacitance with greater nanowire height and decreasing dielectric thickness, consistent with calculations. Leakage current and time-dependent dielectric breakdown (TDDB) are also measured and compared with planar MIS capacitors. In view of greater interest in 3D transistor architectures, such as FinFETs, 3D high density MIS capacitors offer an attractive device technology for analog and mixed signal applications. - See more at: http://www.eurekaselect.com/105099/article#sthash.EzeJxk6j.dpuf

  15. First clinical results of minimally invasive vector lumbar interbody fusion (MIS-VLIF) in spondylodiscitis and concomitant osteoporosis: a technical note.

    Science.gov (United States)

    Rieger, Bernhard; Jiang, Hongzhen; Ruess, Daniel; Reinshagen, Clemens; Molcanyi, Marek; Zivcak, Jozef; Tong, Huaiyu; Schackert, Gabriele

    2017-12-01

    First description of MIS-VLIF, a minimally invasive lumbar stabilization, to evaluate its safety and feasibility in patients suffering from weak bony conditions (lumbar spondylodiscitis and/or osteoporosis). After informed consent, 12 patients suffering from lumbar spondylodiscitis underwent single level MIS-VLIF. Eight of them had a manifest osteoporosis, either. Pre- and postoperative clinical status was documented using numeric rating scale (NRS) for leg and back pain. In all cases, the optimal height for the cage was preoperatively determined using software-based range of motion and sagittal balance analysis. CT scans were obtained to evaluate correct placement of the construct and to verify fusion after 6 months. Since 2013, 12 patients with lumbar pyogenic spondylodiscitis underwent MIS-VLIF. Mean surgery time was 169 ± 28 min and average blood loss was less than 400 ml. Postoperative CT scans showed correct placement of the implants. Eleven patients showed considerable postoperative improvement in clinical scores. In one patient, we observed screw loosening. After documented bony fusion in the CT scan, the fixation system was removed in two cases to achieve lower material load. The load-bearing trajectories (vectors) of MIS-VLIF are different from those of conventional coaxial pedicle screw implantation. The dorsally converging construct combines the heads of the dorsoventral pedicle screws with laminar pedicle screws following cortical bone structures within a small approach. In case of lumbar spondylodiscitis and/or osteoporosis, MIS-VLIF relies on cortical bony structures for all screw vectors and the construct does not depend on conventional coaxial pedicle screws in the presence of inflamed, weak, cancellous or osteoporotic bone. MIS-VLIF allows full 360° lumbar fusion including cage implantation via a small, unilateral dorsal midline approach.

  16. MIS in the management of colon and rectal cancer: consensus meeting of the Colorectal Cancer Association of Canada.

    Science.gov (United States)

    Schlachta, Christopher M; Ashamalla, Shady; Smith, Andy

    2013-11-01

    A consensus conference on the role of minimally invasive surgery (MIS) in the management of colon and rectal cancer was convened by the Colorectal Cancer Association of Canada in Toronto on April 18, 2012. This is a report of the consensus of an invited group of Canadian experts in MIS and surgery of the colon and rectum that addresses the role this technology should play in treatment and also considers advocacy and resources.

  17. Capacitance-voltage characterization of Al/Al2O3/PVA-PbSe MIS diode

    Science.gov (United States)

    Gawri, Isha; Sharma, Mamta; Jindal, Silky; Singh, Harpreet; Tripathi, S. K.

    2018-05-01

    The present paper reports the capacitance-voltage characterization of Al/Al2O3/PVA-PbSe MIS diode using chemical bath deposition method. Here anodic alumina layer prepared using electrolytic deposition method on Al substrate is used as insulating material. Using the capacitance-voltage variation at a fixed frequency, the different parameters such as Depletion layer width, Barrier height, Built-in voltage and Carrier concentration has been calculated at room temperature as well as at temperature range from 123 K to 323 K. With the increase in temperature the barrier height and depletion layer width follow a decreasing trend. Therefore, the capacitance-voltage characterization at different temperatures characterization provides strong evidence that the properties of MIS diode are primarily affected by diode parameters.

  18. GapMis: a tool for pairwise sequence alignment with a single gap.

    Science.gov (United States)

    Flouri, Tomás; Frousios, Kimon; Iliopoulos, Costas S; Park, Kunsoo; Pissis, Solon P; Tischler, German

    2013-08-01

    Pairwise sequence alignment has received a new motivation due to the advent of recent patents in next-generation sequencing technologies, particularly so for the application of re-sequencing---the assembly of a genome directed by a reference sequence. After the fast alignment between a factor of the reference sequence and a high-quality fragment of a short read by a short-read alignment programme, an important problem is to find the alignment between a relatively short succeeding factor of the reference sequence and the remaining low-quality part of the read allowing a number of mismatches and the insertion of a single gap in the alignment. We present GapMis, a tool for pairwise sequence alignment with a single gap. It is based on a simple algorithm, which computes a different version of the traditional dynamic programming matrix. The presented experimental results demonstrate that GapMis is more suitable and efficient than most popular tools for this task.

  19. 1680 : Päikesekuningas asutas riikliku teatri, mis praegu on maailmas vanim / Tõnis Erilaid

    Index Scriptorium Estoniae

    Erilaid, Tõnis, 1943-

    2006-01-01

    21. oktoobril 1680 kirjutas Louis XIV Versailles's alla korraldusele, millega ühendati Moliere'i näitetrupp teise Pariisi näitetrupiga. Sündis La Comedie-Francaise, mis on tänapäevalgi ainus riiklik teater Prantsusmaal

  20. The effect of a slight mis-orientation angle of c-plane sapphire substrate on surface and crystal quality of MOCVD grown GaN thin films

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seong-Woo; Suzuki, Toshimasa [Nippon Institute of Technology, 4-1 Gakuendai, Miyashiro, Saitama, 345-8501 (Japan); Aida, Hideo [NAMIKI Precision Jewel Co. Ltd., 3-8-22 Shinden, Adachi-ku, Tokyo, 123-8511 (Japan)

    2004-09-01

    The effect of a slight mis-orientation of c-plane sapphire substrate on the surface morphology and crystal quality of GaN thin films grown by MOCVD has been investigated. The mis-orientation angle of vicinal c-plane sapphire substrate was changed within the range of 0.00(zero)-1.00(one) degree, and the experimental results were compared with those on just angle (zero degree) c-plane sapphire substrate. The surface morphology and crystal quality were found to be very sensitive to mis-orientation angle. Consequently, the mis-orientation angle was optimized to be 0.15 . (copyright 2004 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  1. Management Information System (MIS: Tool for Monitoring the Waste Management Health Service (RSS and Cost of Treatment

    Directory of Open Access Journals (Sweden)

    Vania Elisabete Schneider

    2013-06-01

    Full Text Available One of the major challenges of solid waste management has been improve and deploy systems that perform monitoring and control of management processes of health service’s waste (HSW. This study aims to evaluate the total cost per category of HSW/day and active bed/day with the handling of HSW in a teaching hospital in northeastern area of Brazil`s Rio Grande do Sul state and identify contributions of a management information system (MIS in the management process, especially considering the generation and segregation of waste. Utilized methodology was developed in two stages: data collection about the management of the HSW and proposition, implementation and feed of a MIS for recording and processing of data related to waste characterization. Results show that whether the management system of the hospital in this study were 100% right, the monthly savings for the treatment of infectious waste would be 18.4% of the costs and 5.83% of costs of chemical waste. The implementation of MIS becomes an essential tool in the evaluation of the management process of HSW since it makes possible to raise issues of fundamental importance to the implementation and evaluation of strategies contained in the HSW management plan. The MIS also represents a tool of easy reference and of great importance to evaluate generation of HSW as it helps to promote the surveillance, identification of sectors that have the biggest problems with segregation, as well as ways to minimize costs and impacts.

  2. Variations of the paleo-productivity in benthic foraminifera records in MIS 3 from western South China Sea

    Science.gov (United States)

    Niu, Y.; Du, J.; Huang, B.; Chen, M.

    2010-12-01

    Understanding climate change of last glacial age as the background information of climate forecasting is particularly important in climate research. Marine Isotope Stage 3 (MIS 3, 61-24 ka B.P.) is a relative warm and unstable period in the last glacial. Millennium scale abrupt climate changes, such as Heinrich events and Dansgaard-Oeschger (D-O) cycles, are identified in this period. Research topic on the variations of monsoon during the glacial cycles, especially in MIS 3, is critical for understanding low latitude climatic change and the global paleo-environment as a whole. Fortunately, high resolution sedimentary records in western South China Sea provide us valuable materials to uncover how East Asia Summer Monsoon (EASM) system acts in a highly fluctuating climate ambient like MIS 3. Core 17954 is located in the modern summer upwelling area off the Vietnam coast in western South China Sea (SCS), its sediments record the variations of upwelling generated by EASM. In this work, we carry out paleo-ecological analyses on planktonic ( Neogloboquadrina dutertrei, Globigerina bulloides) and benthic foraminifera (Bulimina aculeate, Uvigerina peregrina, Cibicidoides wuellerstorfi, ect.) sampled from Core 17954 to investigate paleo-productivity and nutrition change of western SCS and its relation to EASM. The results show that benthic and planktonic foraminifera have similar responses to nutrition change. Various indicators of productivity on the basis of benthic foraminiferal analyses reflect an overall three stage change trend: productivity gradually increases from the beginning of MIS 3 (60-40 ka) to its maximum during 35-30 ka, and finally declines after 30 ka. There is also another important discovery, if we observe the climate change in MIS 3 as a whole, we can also find western SCS and Northern Hemisphere High latitude have strong correspondences in such changes: Heinrich events coincided with high productivity events in the western SCS. Further, the result of

  3. Oceanic response to changes in the WAIS and astronomical forcing during the MIS31 superinterglacial

    Directory of Open Access Journals (Sweden)

    F. Justino

    2017-09-01

    Full Text Available Marine Isotope Stage 31 (MIS31, between 1085 and 1055 ka was characterized by higher extratropical air temperatures and a substantial recession of polar glaciers compared to today. Paleoreconstructions and model simulations have increased the understanding of the MIS31 interval, but questions remain regarding the role of the Atlantic and Pacific oceans in modifying the climate associated with the variations in Earth's orbital parameters. Multi-century coupled climate simulations, with the astronomical configuration of the MIS31 and modified West Antarctic Ice Sheet (WAIS topography, show an increase in the thermohaline flux and northward oceanic heat transport (OHT in the Pacific Ocean. These oceanic changes are driven by anomalous atmospheric circulation and increased surface salinity in concert with a stronger meridional overturning circulation (MOC. The intensified northward OHT is responsible for up to 85 % of the global OHT anomalies and contributes to the overall reduction in sea ice in the Northern Hemisphere (NH due to Earth's astronomical configuration. The relative contributions of the Atlantic Ocean to global OHT and MOC anomalies are minor compared to those of the Pacific. However, sea ice changes are remarkable, highlighted by decreased (increased cover in the Ross (Weddell Sea but widespread reductions in sea ice across the NH.

  4. Ühe minuti loeng: videoformaat, mis tuli ja võitis / Airi Ilisson-Cruz

    Index Scriptorium Estoniae

    Ilisson-Cruz, Airi, 1980-

    2014-01-01

    Tallinna Ülikooli "Ühe Minuti Loengu" videoklippide sarjast, mis võitis Suhtekorralduse Auhind 2013 hariduse eripreemia. Igas klipis arutleb teadlane lihtsas ja loogilises sõnastuses ühe konkreetse, sageli üllatusmomendiga fakti üle. Videoklippide sari kui sisuturunduse näide

  5. Admittance of MIS-Structures Based on HgCdTe with a Double-Layer CdTe/Al2O3 Insulator

    Science.gov (United States)

    Dzyadukh, S. M.; Voitsekhovskii, A. V.; Nesmelov, S. N.; Sidorov, G. Yu.; Varavin, V. S.; Vasil'ev, V. V.; Dvoretsky, S. A.; Mikhailov, N. N.; Yakushev, M. V.

    2018-03-01

    Admittance of MIS structures based on n( p)- Hg1-xCdxTe (at x from 0.22 to 0.40) with SiO2/Si3N4, Al2O3, and CdTe/Al2O3 insulators is studied experimentally at 77 K. Growth of an intermediate CdTe layer during epitaxy results in the almost complete disappearance of the hysteresis of electrophysical characteristics of MIS structures based on graded-gap n-HgCdTe for a small range of the voltage variation. For a wide range of the voltage variation, the hysteresis of the capacitance-voltage characteristics appears for MIS structures based on n-HgCdTe with the CdTe/Al2O3 insulator. However, the hysteresis mechanism differs from that in case of a single-layer Al2O3 insulator. For MIS structures based on p-HgCdTe, introduction of an additional CdTe layer does not lead to a significant decrease of the hysteresis phenomena, which may be due to the degradation of the interface properties when mercury leaves the film as a result of low-temperature annealing changing the conductivity type of the semiconductor.

  6. Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy.

    Science.gov (United States)

    Zhu, Li; Zhai, Ya-Ling; Wang, Feng-Mei; Hou, Ping; Lv, Ji-Cheng; Xu, Da-Min; Shi, Su-Fang; Liu, Li-Jun; Yu, Feng; Zhao, Ming-Hui; Novak, Jan; Gharavi, Ali G; Zhang, Hong

    2015-05-01

    Complement activation is common in patients with IgA nephropathy (IgAN) and associated with disease severity. Our recent genome-wide association study of IgAN identified susceptibility loci on 1q32 containing the complement regulatory protein-encoding genes CFH and CFHR1-5, with rs6677604 in CFH as the top single-nucleotide polymorphism and CFHR3-1 deletion (CFHR3-1∆) as the top signal for copy number variation. In this study, to explore the clinical effects of variation in CFH, CFHR3, and CFHR1 on IgAN susceptibility and progression, we enrolled two populations. Group 1 included 1178 subjects with IgAN and available genome-wide association study data. Group 2 included 365 subjects with IgAN and available clinical follow-up data. In group 1, rs6677604 was associated with mesangial C3 deposition by genotype-phenotype correlation analysis. In group 2, we detected a linkage between the rs6677604-A allele and CFHR3-1∆ and found that the rs6677604-A allele was associated with higher serum levels of CFH and lower levels of the complement activation split product C3a. Furthermore, CFH levels were positively associated with circulating C3 levels and negatively associated with mesangial C3 deposition. Moreover, serum levels of the pathogenic galactose-deficient glycoform of IgA1 were also associated with the degree of mesangial C3 deposition in patients with IgAN. Our findings suggest that genetic variants in CFH, CFHR3, and CFHR1 affect complement activation and thereby, predispose patients to develop IgAN. Copyright © 2015 by the American Society of Nephrology.

  7. Evaluation of SiN films for AlGaN/GaN MIS-HEMTs on Si(111)

    Energy Technology Data Exchange (ETDEWEB)

    Cordier, Y.; Lecotonnec, A.; Chenot, S. [CRHEA-CNRS, Valbonne (France); Baron, N. [CRHEA-CNRS, Valbonne (France); PICOGIGA International, Courtaboeuf (France); Nacer, F.; Goullet, A.; Besland, M.P. [Institut des Materiaux Jean Rouxel IMN, Universite de Nantes (France); Lhermite, H. [Institut d' Electronique et de Telecommunications de Rennes (IETR), Universite de Rennes 1 (France); El Kazzi, M.; Regreny, P.; Hollinger, G. [Institut des Nanotechnologies de Lyon, Ecole Centrale de Lyon, UMR CNRS, Ecully (France)

    2009-06-15

    In this work, AlGaN/GaN HEMT structures grown on Si(111) substrates were covered with SiN{sub x} dielectric films, in order to realize MIS-HEMT devices. The dielectric films have been deposited by plasma enhanced chemical vapor deposition using deposition conditions previously optimized for InP based devices. X-ray photoelectron spectroscopy was used to control the interface formation and characterize the deposited films. Capacitance-voltage, Hall effect and current-voltage measurements were carried out on the MIS-HEMTs and HEMT reference devices and correlated with the dielectric layer quality. (copyright 2009 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  8. Determination of IL-1B (rs16944) and IL-6 (rs1800796) genetic polymorphisms in IgA nephropathy in a northwest Chinese Han population

    OpenAIRE

    Zhang, Daofa; Xie, Maowei; Yang, Xiaohong; Zhang, Yin; Su, Yan; Wang, Yanni; Huang, Haiyang; Han, Hui; Li, Wenning; Fu, Keying; Su, Huiluan; Xu, Wentan; Han, Yeguang; Wang, Ru; Zhang, Pei

    2017-01-01

    IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, but etiology and pathogenesis continue to be poorly understood. Polymorphisms in the cytokine genes may play a role in the etiology and pathogenesis of IgAN. The incidence of different between diverse ethnic groups suggested important genetic influences on its pathogenesis. We genotype 10 single nucleotide polymorphisms (SNPs) in IL-1B and IL-6 gene using Sequenom Mass-ARRAY technology from 417 IgAN patien...

  9. Genetic polymorphisms in HLA-DP and STAT4 are associated with IgA nephropathy in a Southwest Chinese population

    OpenAIRE

    Yang, Bin; Zhang, Junlong; Liu, Xinle; Huang, Zhuochun; Su, Zhenzhen; Liao, Yun; Wang, Lanlan

    2018-01-01

    IgA nephropathy (IgAN) is the most common chronic glomerular disease worldwide. Genetic factors are thought to be crucial in the pathogenesis of IgAN. However, few data are available on the relationship between human leucocyte antigen (HLA) and signal transducer and activator of transcription 4 (STAT4) polymorphisms and IgAN susceptibility in the Chinese population. Therefore, we examined HLA-DP/DQ and STAT4 polymorphisms (rs3077, rs9277535, rs7453920 and rs7574865) in a total of 630 subjects...

  10. Film, ruum ja narratiiv : "Mis juhtus Andres Lapeteusega?" ning "Viini postmark" / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva, 1980-

    2011-01-01

    Analüüsitakse narratiivi aegruumi loomise viise juhtumi analüüsi vormis, vaadeldes kaht eesti mängufilmi : G. Kromanovi "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1966) ja Veljo Käsperi "Viini postmark" (Tallinnfilm, 1967)

  11. Film, ruum ja narratiiv : "Mis juhtus Andres Lapeteusega?" ning "Viini postmark" / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva

    2006-01-01

    Analüüsitakse narratiivi aegruumi loomise viise juhtumi analüüsi vormis, vaadeldes kaht eesti mängufilmi : G. Kromanovi "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1966) ja Veljo Käsperi "Viini postmark" (Tallinnfilm, 1967)

  12. CPP2-p16MIS treatment–induced colon carcinoma cell death in vitro and prolonged lifespan of tumor-bearing mice

    International Nuclear Information System (INIS)

    Wang, Lifeng; Chen, Haijin; Yu, Jinlong; Lin, Xiaohua; Qi, Jia; Cui, Chunhui; Xie, Lang; Huang, Shuxin

    2016-01-01

    Cell-penetrating peptides (CPPs) are a research hotspot due to their noninvasive delivery ability. Among the identified CPPs, the TAT and R8 peptides have been preferentially applied to transduction into different cells. However, this process is nonselective among various cells. Recent research suggested that CPP2 could selectively penetrate human colorectal cancer (CRC) cells. Using in vitro experiments, the mean fluorescence intensity of fluorescein isothiocyanate–labeled CPPs (CPPs-FITC) incubated with different cell lines was compared to corroborate the colon tumor targeting ability of CPP2. The targeting ability of CPP2 was determined in the same way in tumor-bearing mice. We synthesized antitumor peptides by fusing CPP2 to the minimal inhibitory sequence of p16 (p16MIS), which had the ability to restore the function of lost p16, the expression of which was absent in tumor cell lines of various origins. The antitumor effect of the combined peptide was tested in both CRC cell lines and tumor-bearing mice. In each CRC cell line, the mean fluorescence intensity of CPP2-FITC was higher than that of the TAT-FITC (p < 0.001) and R8-FITC (p < 0.001) groups. CPP2-p16MIS, the targeting carrier, showed a higher antitumor response in the in vitro cell research. CPP2-p16MIS showed a prolonged mean lifespan of tumor-bearing mice, further characterizing its role in specific tumor-targeting ability in vivo. Survival analysis showed that the mice treated with CPP2-p16MIS had significantly longer survival than the mice treated with phosphate-buffered saline (p < 0.05) or those treated with control peptides, including the CPP2 (p < 0.05) and p16MIS (p < 0.05) groups. CPP2 could more selectively penetrate CRC cells than TAT or R8 as well as effectively deliver the p16MIS to the tumor

  13. Mis on meie huvid Euroopa Liidus? / Villu Känd

    Index Scriptorium Estoniae

    Känd, Villu

    2007-01-01

    Ilmunud ka: Meie Maa, 4. juuli 2007, lk. 2; Lääne Elu, 5. juuli 2007, lk. 2; Nädaline, 5. juuli 2007, lk. 5; Põhjarannik, 7. juuli 2007, lk. 2; Hiiu Leht, 10. juuli 2007, lk. 2; Severnoje Poberezhje, 10. juuli 2007, lk. 2; Valgamaalane, 12. juuli 2007, lk. 2; Virumaa Teataja, 18. juuli 2007, lk. 11; Oma saar, 18. juuli 2007, lk. 5; Sakala, 19. juuli 2007, lk. 2. Valminud on versioon olulisest poliitikadokumendist, mis võtab kokku Eesti eesmärgid Euroopa Liidus järgnevatel aastatel

  14. Profiling and initial validation of urinary microRNAs as biomarkers in IgA nephropathy

    Directory of Open Access Journals (Sweden)

    Nannan Wang

    2015-06-01

    Full Text Available Background. MicroRNAs (miRNAs have been found in virtually all body fluids and used successfully as biomarkers for various diseases. Evidence indicates that miRNAs have important roles in IgA nephropathy (IgAN, a major cause of renal failure. In this study, we looked for differentially expressed miRNAs in IgAN and further evaluated the correlations between candidate miRNAs and the severity of IgAN.Methods. Microarray and RT-qRCR (real-time quantitative polymerase chain reaction were sequentially used to screen and further verify miRNA expression profiles in urinary sediments of IgAN patients in two independent cohorts. The screening cohort consisted of 32 urine samples from 18 patients with IgAN, 4 patients with MN (membranous nephropathy, 4 patients with MCD (minimal changes disease and 6 healthy subjects; the validation cohort consisted of 102 IgAN patients, 41 MN patients, 27 MCD patients and 34 healthy subjects. The renal pathological lesions of patients with IgAN were evaluated according to Lee’s grading system and Oxford classification.Results. At the screening phase, significance analysis of microarrays analysis showed that no miRNA was differentially expressed in the IgAN group compared to all control groups. But IgAN grade I–II and III subgroups (according to Lee’s grading system shared dysregulation of two miRNAs (miR-3613-3p and miR-4668-5p. At the validation phase, RT-qPCR results showed that urinary level of miR-3613-3p was significantly lower in IgAN than that in MN, MCD and healthy controls (0.47, 0.44 and 0.24 folds, respectively, all P < 0.01 by Mann–Whitney U test; urinary level of miR-4668-5p was also significantly lower in IgAN than that in healthy controls (0.49 fold, P < 0.01. Significant correlations were found between urinary levels of miR-3613-3p with 24-hour urinary protein excretion (Spearman r = 0.50, P = 0.034, eGFR (estimated glomerular filtration rate (r = − 0.48, P = 0.043 and Lee’s grades (r = 0.57, P

  15. Reshould I Take More MIS Courses? Implications from Interviews with Business Recruiters

    Science.gov (United States)

    He, Jun; Guo, Yi Maggie

    2015-01-01

    It is important for MIS educators to have a good understanding of what IT knowledge and skills are required in business. In this study, 103 open job positions in the Midwestern United States were investigated via semi-structured interviews with hiring companies. The interviews with key business recruiters suggest that IT knowledge and skills are…

  16. Final Validation of the ProMisE Molecular Classifier for Endometrial Carcinoma in a Large Population-based Case Series.

    Science.gov (United States)

    Kommoss, S; McConechy, M K; Kommoss, F; Leung, S; Bunz, A; Magrill, J; Britton, H; Kommoss, F; Grevenkamp, F; Karnezis, A; Yang, W; Lum, A; Krämer, B; Taran, F; Staebler, A; Lax, S; Brucker, S Y; Huntsman, D G; Gilks, C B; McAlpine, J N; Talhouk, A

    2018-02-07

    Based on The Cancer Genome Atlas, we previously developed and confirmed a pragmatic molecular classifier for endometrial cancers; ProMisE (Proactive Molecular Risk Classifier for Endometrial Cancer). ProMisE identifies four prognostically distinct molecular subtypes, and can be applied to diagnostic specimens (biopsy/curettings), enabling earlier informed decision-making. We have strictly adhered to the Institute of Medicine (IOM) guidelines for the development of genomic biomarkers, and herein present the final validation step of a locked-down classifier prior to clinical application. We assessed a retrospective cohort of women from the Tübingen University Women's Hospital treated for endometrial carcinoma between 2003-13. Primary outcomes of overall, disease-specific and progression-free survival were evaluated for clinical, pathological, and molecular features. Complete clinical and molecular data were evaluable from 452 women. Patient age ranged from 29 - 93 (median 65) years, and 87.8% cases were endometrioid histotype. Grade distribution included 282 (62.4%) G1, 75 (16.6%) G2, and 95 (21.0%) G3 tumors. 276 (61.1%) patients had stage IA disease, with the remaining stage IB (89 (19.7%)), stage II (26 (5.8%)), and stage III/IV (61 (13.5%)). ProMisE molecular classification yielded 127 (28.1%) MMR-D, 42 (9.3%) POLE, 55 (12.2%) p53abn, and 228 (50.4%) p53wt. ProMisE was a prognostic marker for progression-free (P=0.001) and disease-specific (P=0.03) survival even after adjusting for known risk factors. Concordance between diagnostic and surgical specimens was highly favorable; accuracy 0.91, kappa 0.88. We have developed, confirmed and now validated a pragmatic molecular classification tool (ProMisE) that provides consistent categorization of tumors and identifies four distinct prognostic molecular subtypes. ProMisE can be applied to diagnostic samples and thus could be used to inform surgical procedure(s) and/or need for adjuvant therapy. Based on the IOM

  17. The complexity of millennial-scale variability in southwestern Europe during MIS 11

    Science.gov (United States)

    Oliveira, Dulce; Desprat, Stéphanie; Rodrigues, Teresa; Naughton, Filipa; Hodell, David; Trigo, Ricardo; Rufino, Marta; Lopes, Cristina; Abrantes, Fátima; Sánchez Goñi, Maria Fernanda

    2016-11-01

    Climatic variability of Marine Isotope Stage (MIS) 11 is examined using a new high-resolution direct land-sea comparison from the SW Iberian margin Site U1385. This study, based on pollen and biomarker analyses, documents regional vegetation, terrestrial climate and sea surface temperature (SST) variability. Suborbital climate variability is revealed by a series of forest decline events suggesting repeated cooling and drying episodes in SW Iberia throughout MIS 11. Only the most severe events on land are coeval with SST decreases, under larger ice volume conditions. Our study shows that the diverse expression (magnitude, character and duration) of the millennial-scale cooling events in SW Europe relies on atmospheric and oceanic processes whose predominant role likely depends on baseline climate states. Repeated atmospheric shifts recalling the positive North Atlantic Oscillation mode, inducing dryness in SW Iberia without systematical SST changes, would prevail during low ice volume conditions. In contrast, disruption of the Atlantic meridional overturning circulation (AMOC), related to iceberg discharges, colder SST and increased hydrological regime, would be responsible for the coldest and driest episodes of prolonged duration in SW Europe.

  18. Sea-level highstands during the Last interglacial (MIS 5e) in Mallorca

    Science.gov (United States)

    Lorscheid, T.; Stocchi, P.; Rovere, A.; Gómez-Pujol, L.; Mann, T.; Fornos, J. J.

    2015-12-01

    Last Intergalcial in the island of Mallorca (NW Mediterranean) have been the subject of research since the early 60's (Butzer & Cuerda 1960). Despite both the location and stratigraphy of MIS 5e outcrops in the island are well known, the elevation of relative sea level (RSL) markers around the island has never been measured with high-accuracy topographic techniques (e.g. DGPS) and the interpretation of the paleo RSL has never been carried out using standardized definition of the indicative meaning of each RSL marker. In this study we present the results of two field trips aimed at measuring last interglacial deposits in Mallorca with high-accuracy GPS and at establishing, surveying modern shorelines as analogs, indicative ranges and reference water level values for RSL markers across the island. Using an earth-ice coupled GIA-model we performed several model-runs for investigating isostatic adjustment since MIS 5e in the island. These results are compared with the elevation of our deposits in the field and discussed in terms of tectonics and eustasy.

  19. Fully solution processed Al-TiO2-Si (MIS) structured photo-detector

    Science.gov (United States)

    Mondal, Sandip; Kumar, Arvind

    2018-05-01

    We demonstrate the fabrication of a high performance photo detector by fully solution processed technique. The detector is fabricated with photo sensitive, low temperature (200˚C) and sol-gel processed titanium dioxide (TiO2) dielectric material on silicon substrate in the form of MIS structure with top aluminum gate. The optical detection experiment is performed on Al—TiO2—Si (MIS) device by measuring the capacitance—voltage (CV at 100 kHz) curve within the visible region of light (365 — 700 nm). The presence of light shift the flat band voltage (VFB) from 290 mV to 360 mV due to the generation of photo activated charge carriers by UV (365 nm) and white light, respectively. Moreover, the generation of the charge carrier increases drastically by the combination of UV and white, which resulting as a very large shift (600 mV) in the VFB. The entire experiment was performed in normal lab conditions with open air environment, without any clean room facility.

  20. Optimization of MIS/IL solar cells parameters using genetic algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, K.A.; Mohamed, E.A.; Alaa, S.H. [Faculty of Engineering, Alexandria Univ. (Egypt); Motaz, M.S. [Institute of Graduate Studies and Research, Alexandria Univ. (Egypt)

    2004-07-01

    This paper presents a genetic algorithm optimization for MIS/IL solar cell parameters including doping concentration NA, metal work function {phi}m, oxide thickness d{sub ox}, mobile charge density N{sub m}, fixed oxide charge density N{sub ox} and the external back bias applied to the inversion grid V. The optimization results are compared with theoretical optimization and shows that the genetic algorithm can be used for determining the optimum parameters of the cell. (orig.)

  1. Particle mis-identification rate algorithm for the CLIC ILD and CLIC SiD detectors

    CERN Document Server

    Nardulli, J

    2011-01-01

    This note describes the algorithm presently used to determine the particle mis- identification rate and gives results for single particles for the CLIC ILD and CLIC SiD detector concepts as prepared for the CLIC Conceptual Design Report.

  2. Kust tuleb koolirõõm, mis paneb õpetaja silma särama? / Kirsti Rumma

    Index Scriptorium Estoniae

    Rumma, Kirsti

    2017-01-01

    Tallinna Ülikooli haridusinnovatsiooni keskuse poolt Eesti kooliõpilaste ja õpetajate seas läbi viidud uuringust, kus muuhulgas otsiti vastuseid küsimustele, kust tuleb õpilaste koolirõõm ja mis mõjutab õpetajate silmasära

  3. Links between Patagonian Ice Sheet fluctuations and Antarctic dust variability during the last glacial period (MIS 4-2)

    Science.gov (United States)

    Kaiser, Jérôme; Lamy, Frank

    2010-06-01

    Antarctic and Greenland ice-core records reveal large fluctuations of dust input on both orbital and millennial time-scales with potential global climate implications. At least during glacial periods, the Antarctic dust fluctuations appear to be largely controlled by environmental changes in southern South America. We compare dust flux records from two Antarctic ice-cores to variations in the composition of the terrigenous supply at ODP Site 1233 located off southern Chile and known to record fluctuations in the extent of the northern part of the Patagonian ice-sheet (NPIS) during the last glacial period (Marine Isotope Stage, MIS, 4 to 2). Within age uncertainties, millennial-scale glacial advances (retreats) of the NPIS correlate to Antarctic dust maxima (minima). In turn, NPIS fluctuations were closely related to offshore sea surface temperature (SST) changes. This pattern suggests a causal link involving changes in temperature, in rock flour availability, in latitudinal extensions of the westerly winds and in foehn winds in the southern Pampas and Patagonia. We further suggest that the long-term trend of dust accumulation is partly linked to the sea-level related changes in the size if the Patagonian source area due to the particular morphology of the Argentine shelf. We suggest that sea-level drops at the beginning of MIS 4 and MIS 2 were important for long-term dust increases, while changes in the Patagonian dust source regions primarily control the early dust decrease during the MIS 4/3 transition and Termination 1.

  4. IgA nephropathy and Henoch-Schönlein nephritis in adults : with special reference to factors affecting outcome

    OpenAIRE

    Rauta, Virpi

    2006-01-01

    IgA nephropathy (IgAN) is the most common primary glomerulonephritis. In one third of the patients the disease progresses, and they eventually need renal replacement therapy. IgAN is in most cases a slowly progressing disease, and the prediction of progression has been difficult, and the results of studies have been conflicting. Henoch-Schönlein nephritis (HSN) is rare in adults, and prediction of the outcome is even more difficult than in IgAN. This study was conducted to evaluate the c...

  5. Kosovo - doominokivi, mis kohutab Venemaad ja teisi veriseid võime / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2008-01-01

    Autor analüüsib probleeme, mis on seotud Kosovo iseseisvumisega. Uue riigi teke 21. sajandi alguse Euroopas ei tohiks olla midagi erakordset, sest viimase poole sajandi jooksul on nähtud kümnete riikide sündi, arvab ta. Lisad: Doominokivid; Iseseisvunud riikide arv 1958-2006; Järjekorras ootavad; Millal algas uute riikide iseseisvumise doomino?

  6. Evaluation and Reliability Assessment of GaN-on-Si MIS-HEMT for Power Switching Applications

    Directory of Open Access Journals (Sweden)

    Po-Chien Chou

    2017-02-01

    Full Text Available This paper reports an extensive analysis of the physical mechanisms responsible for the failure of GaN-based metal–insulator–semiconductor (MIS high electron mobility transistors (HEMTs. When stressed under high applied electric fields, the traps at the dielectric/III-N barrier interface and inside the III-N barrier cause an increase in dynamic on-resistance and a shift of threshold voltage, which might affect the long term stability of these devices. More detailed investigations are needed to identify epitaxy- or process-related degradation mechanisms and to understand their impact on electrical properties. The present paper proposes a suitable methodology to characterize the degradation and failure mechanisms of GaN MIS-HEMTs subjected to stress under various off-state conditions. There are three major stress conditions that include: VDS = 0 V, off, and off (cascode-connection states. Changes of direct current (DC figures of merit in voltage step-stress experiments are measured, statistics are studied, and correlations are investigated. Hot electron stress produces permanent change which can be attributed to charge trapping phenomena and the generation of deep levels or interface states. The simultaneous generation of interface (and/or bulk and buffer traps can account for the observed degradation modes and mechanisms. These findings provide several critical characteristics to evaluate the electrical reliability of GaN MIS-HEMTs which are borne out by step-stress experiments.

  7. 48 CFR 226.370-8 - Goals and incentives for subcontracting with HBCU/MIs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Goals and incentives for subcontracting with HBCU/MIs. 226.370-8 Section 226.370-8 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Historically Black Colleges and...

  8. Automated software development tools in the MIS (Management Information Systems) environment

    Energy Technology Data Exchange (ETDEWEB)

    Arrowood, L.F.; Emrich, M.L.

    1987-09-11

    Quantitative and qualitative benefits can be obtained through the use of automated software development tools. Such tools are best utilized when they complement existing procedures and standards. They can assist systems analysts and programmers with project specification, design, implementation, testing, and documentation. Commercial products have been evaluated to determine their efficacy. User comments have been included to illustrate actual benefits derived from introducing these tools into MIS organizations.

  9. Response of the North Atlantic surface and intermediate ocean structure to climate warming of MIS 11.

    Science.gov (United States)

    Kandiano, Evgenia S; van der Meer, Marcel T J; Schouten, Stefan; Fahl, Kirsten; Sinninghe Damsté, Jaap S; Bauch, Henning A

    2017-04-10

    Investigating past interglacial climates not only help to understand how the climate system operates in general, it also forms a vital basis for climate predictions. We reconstructed vertical stratification changes in temperature and salinity in the North Atlantic for a period some 400 ka ago (MIS11), an interglacial time analogue of a future climate. As inferred from a unique set of biogeochemical, geochemical, and faunal data, the internal upper ocean stratification across MIS 11 shows distinct depth-dependent dynamical changes related to vertical as well as lateral shifts in the upper Atlantic meridional circulation system. Importantly, transient cold events are recognized near the end of the long phase of postglacial warming at surface, subsurface, mid, and deeper water layers. These data demonstrate that MIS 11 coolings over the North Atlantic were initially triggered by freshwater input at the surface and expansion of cold polar waters into the Subpolar Gyre. The cooling signal was then transmitted downwards into mid-water depths. Since the cold events occurred after the main deglacial phase we suggest that their cause might be related to continuous melting of the Greenland ice sheet, a mechanism that might also be relevant for the present and upcoming climate.

  10. Density of interface states, excess capacitance and series resistance in the metal-insulator-semiconductor (MIS) solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Altindal, Semsettin; Tataroglu, Adem; Dokme, Ilbilge [Faculty of Arts and Sciences, Physics Department, Gazi University, 06500, Ankara (Turkey)

    2005-01-31

    Dark and illuminated current-voltage (I-V) characteristics of Al/SiO{sub x}/p-Si metal-insulator-semiconductor (MIS) solar cells were measured at room temperature. In addition to capacitance-voltage (C-V) and conductance-voltage (G-V), characteristics are studied at a wide frequency range of 1kHz-10MHz. The dark I-V characteristics showed non-ideal behavior with an ideal factor of 3.2. The density of interface states distribution profiles as a function of (E{sub ss}-E{sub v}) deduced from the I-V measurements at room temperature for the MIS solar cells on the order of 10{sup 13}cm{sup -2}eV{sup -1}. These interface states were responsible for the non-ideal behavior of I-V, C-V and G-V characteristics. Frequency dispersion in capacitance for MIS solar cells can be interpreted only in terms of interface states. The interface states can follow the a.c. signal and yield an excess capacitance, which depends on the relaxation time of interface states and the frequency of the a.c. signal. It was observed that the excess capacitance C{sub o} caused by an interface state decreases with an increase of frequency. The capacitances characteristics of MIS solar cells are affected not only in interface states but also series resistance. Analysis of this data indicated that the high interface states and series resistance leads to lower values of open-circuit voltage, short-circuit current density, and fill factor. Experimental results show that the location of interface states and series resistance have a significant effect on I-V, C-V and G-V characteristics.

  11. Reconstructing dust fluxes and paleoproductivity at the southern Agulhas Plateau since MIS-6

    Science.gov (United States)

    Frenkel, M. M.; Anderson, R. F.; Winckler, G.

    2017-12-01

    Understanding the mechanisms underlying glacial-interglacial cycles requires characterizing the role of oceanic feedbacks in climatic changes. For example, increased aeolian iron fluxes to Fe-limited regions of the ocean and corresponding changes in marine productivity could have improved biological pump efficiency and resulted in CO2 drawdown. Here we explore these feedbacks using marine sediment core MDO2-2588 collected from the southern Agulhas Plateau (SAP; 41°S, 26°E), located beneath the modern subtropical front. Today, diatom productivity in this region is Si-limited because high Si utilization south of the polar front (PF) means that water advected northward to our study site is Si-depleted. However, previous work has suggested that extended sea ice cover during glacial periods may have limited diatom productivity south of the PF while frontal systems shifted northward, allowing more Si to reach thermocline of the SAP. Meanwhile, increased glacial dust flux to the SAP may have simultaneously supplied more Fe, contributing to higher glacial productivity. This hypothesis has been supported by observations of higher LGM and MIS-6 productivity at MD02-2588 using bulk biogenic content and diatom assemblages (Romero et al., Paleoceanography, 30 (2015) 118-132). Gradients in d13C between benthic and planktic foraminifera have also been used to support Fe fertilization at this site on millennial timescales (Ziegler et al., Nature Geoscience, 6 (2013) 457-461). Yet, studies have yet to produce coordinated records of dust flux and export production for the SAP. Here, we present records of dust, based on 230Th-normalized 232Th fluxes, and export production using 230Th-normalized excess-Ba and opal fluxes and authigenic U through MIS-6. Preliminary results show that lithogenic fluxes to MD02-2588 were approximately twice as high during MIS-6 as MIS-5e and were concurrent with a two-fold increase in excess-Ba flux. However, this relative increase in lithogenic flux

  12. Pengaruh Pemijatan Perineum pada Primigravida terhadap Kejadian Ruptur Perineum saat Persalinan di Bidan Praktek Mandiri di Kota Bengkulu Tahun 2014

    Directory of Open Access Journals (Sweden)

    Wewet Savitri

    2015-01-01

    Full Text Available AbstrakRuptur perineum merupakan salah satu komplikasi persalinan kala II yang dapat menyebabkan disfungsi organ reproduksi wanita, perdarahan dan laserasi. Sebanyak 85% wanita melahirkan pervaginam dapat mengalami ruptur perineum. Salah satu cara mengurangi ruptur perineum adalah dengan melakukan pemijatan perineum untuk meningkatkan kesehatan, aliran darah dan elastisitas perineum. Tujuan penelitian ini adalah untuk menentukan pengaruh pemijatan perineum pada primigravida terhadap kejadian ruptur perineum saat persalinan di Bidan Praktek Mandiri di Kota Bengkulu Tahun 2014. Penelitian ini merupakan penelitian quasi eksperimen dengan metode post test only control group design. Penelitian dilakukan di Bidan Praktek Mandiri (BPM kota Bengkulu dengan subjek 28 orang primigravida usia kehamilan 36 minggu yang terdiri dari 14 orang kelompok intervensi dan 14 orang kelompok kontrol. Penelitian dilakukan dari 10 Maret 2014 hingga 10 Mei 2014, kemudian data dianalisis dengan uji Chi Square. Kejadian ruptur perineum pada kelompok intervensi setelah dilakukan pemijatan perineum hanya 21,4% sementara pada kelompok kontrol 71,4%. Hasil penelitian membuktikan ada pengaruh pemijatan perineum pada primigravida terhadap kejadian ruptur perineum (p<0,05. Penelitian ini menyimpulkan bahwa pemijatan perineum pada primigravida berpengaruh terhadap kejadian ruptur perineum pada saat persalinan.Kata kunci: pemijatan perineum, primigravida, ruptur perineumAbstractPerineal rupture is one of the second stage of labor complications that can lead to dysfunction of the female reproductive organs, bleeding and lacerations. As many as 85% of women give birth vaginally may experience rupture of the perineum. A method of reduce perineal rupture is a perineal massage to promote health, blood flow and elasticity of the perineum. The objekctive of this study was to determine the effect of perineal massage on the incidence of perineal rupture in primigravid during childbirth in

  13. A coccolithophore based view on paleoenvironmental changes in the open ocean mid-latitude North Atlantic between 130 and 48ka BP with special emphasis on MIS 5e

    DEFF Research Database (Denmark)

    Schwab, C.; Kinkel, Hanno; Weinelt, M.

    2013-01-01

    in coccolithophore assemblages and changes in the abundance of siliceous plankton (diatoms) indicate a southward shift of the Azores Front (AzF), and hence a southward retreat of the North Atlantic subtropical gyre, as well as an increased productivity, during glacial Marine Isotope Stage (MIS) 4, Termination II...... and during cold substages of MIS 5. Furthermore we hypothesize that the ecological changes led to distinct evolutionary patterns of coccolithophores, resulting e.g. in a dominance of Gephyrocapsa ornata between 76 and 105ka BP. Additionally, high-resolution analysis of MIS 5e indicate a short reversal...... towards cool conditions during MIS 5e, corresponding to a basin-wide cooling event. Full interglacial conditions are reached only late in the Azores region. During MIS 5e an increased advection of Subantarctic Mode Water (SAMW), and/or the possibility to occupy new habitats after glacial conditions...

  14. Severe Adverse Effects Associated With Corticosteroid Treatment in Patients With IgA Nephropathy

    Directory of Open Access Journals (Sweden)

    Qingqing Cai

    2017-07-01

    Discussion: Corticosteroid use is associated with a high risk of SAEs in IgAN patients, especially those who are older, have hypertension, or impaired renal function. Current guidelines on corticosteroid regimens in IgAN should be reviewed with regard to safety.

  15. The Use of Facebook in an Introductory MIS Course: Social Constructivist Learning Environment

    Science.gov (United States)

    Ractham, Peter; Kaewkitipong, Laddawan; Firpo, Daniel

    2012-01-01

    The major objective of this article is to evaluate via a Design Science Research Methodology (DSRM) the implementation of a Social Constructivist learning framework for an introductory Management Information System (MIS) course. Facebook was used as a learning artifact to build and foster a learning environment, and a series of features and…

  16. Basic mechanisms study for MIS solar cell structures on GaAs

    Science.gov (United States)

    Fonash, S. J.

    1978-01-01

    The solar cell structure examined is the MIS configuration on (n) GaAs. The metal room temperature oxide/(n) GaAs materials system was studied. Metals with electronegativities varying from 2.4 (Au) to 1.5 (Al) were used as the upper electrode. The thinnest metallization that did not interfere with the measurement techniques (by introducing essentially transmission line series resistance problems across a device) was used. Photovoltaic response was not optimized.

  17. Duodenal Atresia: Open versus MIS Repair—Analysis of Our Experience over the Last 12 Years

    Directory of Open Access Journals (Sweden)

    Salvatore Fabio Chiarenza

    2017-01-01

    Full Text Available Objective. Duodenal atresia (DA routinely has been corrected by laparotomy and duodenoduodenostomy with excellent long-term results. We revisited the patients with DA treated in the last 12 years (2004–2016 comparing the open and the minimally invasive surgical (MIS approach. Methods. We divided our cohort of patients into two groups. Group 1 included 10 patients with CDO (2004–09 treated with open procedure: 5, DA; 3, duodenal web; 2, extrinsic obstruction. Three presented with Down’s syndrome while 3 presented with concomitant malformations. Group 2 included 8 patients (2009–16: 1, web; 5, DA; 2, extrinsic obstruction. Seven were treated by MIS; 1 was treated by Endoscopy. Three presented with Down’s syndrome; 3 presented with concomitant malformations. Results. Average operating time was 120 minutes in Group 1 and 190 minutes in Group 2. In MIS Group the visualization was excellent. We recorded no intraoperative complications, conversions, or anastomotic leakage. Feedings started on 3–7 postoperative days. Follow-up showed no evidence of stricture or obstruction. In Group 1 feedings started within 10–22 days and we have 1 postoperative obstruction. Conclusions. Laparoscopic repair of DA is one of the most challenging procedures among pediatric laparoscopic procedures. These patients had a shorter length of hospitalization and more rapid advancement to full feeding compared to patients undergoing the open approach. Laparoscopic repair of DA could be the preferred technique, safe, and efficacious, in the hands of experienced surgeons.

  18. Chironomid-based reconstructions of summer air temperature from lake deposits in Lyndon Stream, New Zealand spanning the MIS 3/2 transition

    Science.gov (United States)

    Woodward, C. A.; Shulmeister, J.

    2007-01-01

    We present chironomid-based temperature reconstructions from lake sediments deposited between ca 26,600 cal yr BP and 24,500 cal yr BP from Lyndon Stream, South Island, New Zealand. Summer (February mean) temperatures averaged 1 °C cooler, with a maximum inferred cooling of 3.7 °C. These estimates corroborate macrofossil and beetle-based temperature inferences from the same site and suggest climate amelioration (an interstadial) at this time. Other records from the New Zealand region also show a large degree of variability during the late Otiran glacial sequence (34,000-18,000 cal yr BP) including a phase of warming at the MIS 2/3 transition and a maximum cooling that did not occur until the global LGM (ca 20,000 cal yr BP). The very moderate cooling identified here at the MIS 2/3 transition confirms and enhances the long-standing discrepancy in New Zealand records between pollen and other proxies. Low abundances (<20%) of canopy tree pollen in records from late MIS 3 to the end of MIS 2 cannot be explained by the minor (<5 °C) cooling inferred from this and other studies unless other environmental parameters are considered. Further work is required to address this critical issue.

  19. The Valle di Manche section (Calabria, Southern Italy): A high resolution record of the Early-Middle Pleistocene transition (MIS 21-MIS 19) in the Central Mediterranean

    Science.gov (United States)

    Capraro, Luca; Ferretti, Patrizia; Macrì, Patrizia; Scarponi, Daniele; Tateo, Fabio; Fornaciari, Eliana; Bellini, Giulia; Dalan, Giorgia

    2017-06-01

    The on-land marine Valle di Manche section (Crotone Basin, Calabria, Southern Italy), one of the candidates to host the GSSP of the Middle Pleistocene (;Ionian;) Stage, preserves a manifold record of independent chronological, paleoclimatic and stratigraphic proxies that permit a straightforward correlation with marine and terrestrial reference records at the global scale. In particular, the section holds an excellent record of the Matuyama-Brunhes magnetic reversal, which occurs in the midst of Marine Isotope Stage (MIS) 19. We report on a complete revision of the section that improves dramatically the available dataset, especially in the stratigraphic interval straddling the Lower-Middle Pleistocene boundary. Our benthic δ18O record provides evidence that the Matuyama-Brunhes transition, the stratigraphic position of which is marked by a prominent tephra (the ;Pitagora ash;), occurred during full MIS 19, in agreement with many records worldwide. We obtained an age of 786.9 ± 5 ka for the Matuyama-Brunhes magnetic reversal and pinpointed the paleomagnetic transition of to a 3 cm-thick interval, indicating that the event was very fast. Since the section fulfills all the requirements to host the GSSP of the Ionian Stage, we propose that the boundary should be placed at the base of the ;Pitagora ash;, ca. 12.5 cm below the midpoint of the Matuyama-Brunhes reversal.

  20. Intrinsic renal cells induce lymphocytosis of Th22 cells from IgA nephropathy patients through B7-CTLA-4 and CCL-CCR pathways.

    Science.gov (United States)

    Gan, Lu; Zhou, Qiaoling; Li, Xiaozhao; Chen, Chen; Meng, Ting; Pu, Jiaxi; Zhu, Mengyuan; Xiao, Chenggen

    2018-04-01

    IgA nephropathy (IgAN), the most common glomerulonephritis, has an unclear pathogenesis. The role of Th22 cells, which are intimately related to proteinuria and progression in IgAN, in mediating infection-related IgAN is unclear. This study aimed to characterize the association between intrinsic renal cells (tubular epithelial cells and mesangial cells) and Th22 cells in immune regulation of infection-related IgAN and to elucidate the impact of Th22 lymphocytosis; the proinflammatory cytokines IL-1, IL-6, and TNF-α; and CCL chemokines on kidney fibrosis. Hemolytic streptococcus infection induced an increase in IL-1, IL-6, and TNF-α, resulting in Th22 cell differentiation from T lymphocytes obtained from patients with IgAN, and the CCL20-CCR6, CCL22-CCR4, and/or CCL27-CCR10 axes facilitated Th22 cell chemotaxis. The increased amount of Th22 cells caused an increase in TGF-β1 levels, and anti-CD80, anti-CD86, and CTLA-4Ig treatment reduced TGF-β1 levels by inhibiting Th22 lymphocytosis and secretion of cytokines and chemokines, thus potentially relieving kidney fibrosis. Our data suggest that Th22 cells might be recruited into the kidneys via the CCL20-CCR6, CCL22-CCR4, and/or CCL27-CCR10 axes by mesangial cells and tubular epithelial cells in infection-related IgAN. Th22 cell overrepresentation was attributed to stimulation of the B7-CTLA-4Ig antigen-presenting pathway and IL-1, IL-6, and TNF-α.

  1. Cellular Signaling and Production of Galactose-Deficient IgA1 in IgA Nephropathy, an Autoimmune Disease

    Directory of Open Access Journals (Sweden)

    Colin Reily

    2014-01-01

    Full Text Available Immunoglobulin A (IgA nephropathy (IgAN, the leading cause of primary glomerulonephritis, is characterized by IgA1-containing immunodeposits in the glomeruli. IgAN is a chronic disease, with up to 40% of patients progressing to end-stage renal disease, with no disease-specific treatment. Multiple studies of the origin of the glomerular immunodeposits have linked elevated circulating levels of aberrantly glycosylated IgA1 (galactose-deficient in some O-glycans; Gd-IgA1 with formation of nephritogenic Gd-IgA1-containing immune complexes. Gd-IgA1 is recognized as an autoantigen in susceptible individuals by anti-glycan autoantibodies, resulting in immune complexes that may ultimately deposit in the kidney and induce glomerular injury. Genetic studies have revealed that an elevated level of Gd-IgA1 in the circulation of IgAN patients is a hereditable trait. Moreover, recent genome-wide association studies have identified several immunity-related loci that associated with IgAN. Production of Gd-IgA1 by IgA1-secreting cells of IgAN patients has been attributed to abnormal expression and activity of several key glycosyltransferases. Substantial evidence is emerging that abnormal signaling in IgA1-producing cells is related to the production of Gd-IgA1. As Gd-IgA1 is the key autoantigen in IgAN, understanding the genetic, biochemical, and environmental aspects of the abnormal signaling in IgA1-producing cells will provide insight into possible targets for future disease-specific therapy.

  2. Evidence from the Oxford Classification cohort supports the clinical value of subclassification of focal segmental glomerulosclerosis in IgA nephropathy

    NARCIS (Netherlands)

    Bellur, Shubha S.; Lepeytre, Fanny; Vorobyeva, Olga; Troyanov, Stéphan; Cook, H. Terence; Roberts, Ian S. D.; Alpers, Charles E.; Amore, Alessandro; Barratt, Jonathan; Berthoux, Francois; Bonsib, Stephen; Bruijn, Jan A.; Cattran, Daniel C.; Coppo, Rosanna; D'Agati, Vivette; D'Amico, Giuseppe; Emancipator, Steven; Emma, Francesco; Feehally, John; Ferrario, Franco; Fervenza, Fernando C.; Florquin, Sandrine; Fogo, Agnes; Geddes, Colin C.; Groene, Hermann-Josef; Haas, Mark; Herzenberg, Andrew M.; Hill, Prue A.; Hogg, Ronald J.; Hsu, Stephen I.; Jennette, J. Charles; Joh, Kensuke; Julian, Bruce A.; Kawamura, Tetsuya; Lai, Fernand M.; Li, Lei-Shi; Li, Philip K. T.; Liu, Zhi-Hong; Mackinnon, Bruce; Mezzano, Sergio; Schena, F. Paolo; Tomino, Yasuhiko; Walker, Patrick D.; Wang, Haiyan; Weening, Jan J.; Yoshikawa, Nori; Zhang, Hong

    2017-01-01

    Focal segmental glomerulosclerosis (FSGS) is a common finding in IgA nephropathy (IgAN). Here we assessed FSGS lesions in the Oxford Classification patient cohort and correlated histology with clinical presentation and outcome to determine whether subclassification of the S score in IgAN is

  3. "Mis on see luuletaja luule..." : [luuletused] / Juhan Viiding

    Index Scriptorium Estoniae

    Viiding, Juhan, 1948-1995

    2001-01-01

    Tekst eesti ja inglise k. J. Viidingu lühibiograafia eesti ja inglise k. lk. 151. Sisu: "Mis on see luuletaja luule..." = "So what is a poet's poetry then..." ; Eluküsimus = A question of life ; "sügisemees..." = "the autumn man..." ; "Lamades, seistes ja istudes..." = "Lying, standing or sitting..." ; "öö käest pannakse päeva käele..." = "from the hand of night to the hand of day..." ; "sa karjatad pikalt ja valuga..." = "you scream long and hard..." ; Tee = The road ; "tuisk on kolmandat päeva..." = "its's day three of the blizzard..." ; Latern = Street lamp ; "Eluaeg olen tahtnud õue..." = "All my life, I've wanted out..." ; "su südamepuuris on vaikus..." = "In the cage of your heart there is silence..."

  4. Challenges of DHS and MIS to capture the entire pattern of malaria parasite risk and intervention effects in countries with different ecological zones: the case of Cameroon.

    Science.gov (United States)

    Massoda Tonye, Salomon G; Kouambeng, Celestin; Wounang, Romain; Vounatsou, Penelope

    2018-04-06

    In 2011, the demographic and health survey (DHS) in Cameroon was combined with the multiple indicator cluster survey. Malaria parasitological data were collected, but the survey period did not overlap with the high malaria transmission season. A malaria indicator survey (MIS) was also conducted during the same year, within the malaria peak transmission season. This study compares estimates of the geographical distribution of malaria parasite risk and of the effects of interventions obtained from the DHS and MIS survey data. Bayesian geostatistical models were applied on DHS and MIS data to obtain georeferenced estimates of the malaria parasite prevalence and to assess the effects of interventions. Climatic predictors were retrieved from satellite sources. Geostatistical variable selection was used to identify the most important climatic predictors and indicators of malaria interventions. The overall observed malaria parasite risk among children was 33 and 30% in the DHS and MIS data, respectively. Both datasets identified the Normalized Difference Vegetation Index and the altitude as important predictors of the geographical distribution of the disease. However, MIS selected additional climatic factors as important disease predictors. The magnitude of the estimated malaria parasite risk at national level was similar in both surveys. Nevertheless, DHS estimates lower risk in the North and Coastal areas. MIS did not find any important intervention effects, although DHS revealed that the proportion of population with an insecticide-treated nets access in their household was statistically important. An important negative relationship between malaria parasitaemia and socioeconomic factors, such as the level of mother's education, place of residence and the household welfare were captured by both surveys. Timing of the malaria survey influences estimates of the geographical distribution of disease risk, especially in settings with seasonal transmission. In countries with

  5. Detection and correction of false segmental duplications caused by genome mis-assembly

    Science.gov (United States)

    2010-01-01

    Diploid genomes with divergent chromosomes present special problems for assembly software as two copies of especially polymorphic regions may be mistakenly constructed, creating the appearance of a recent segmental duplication. We developed a method for identifying such false duplications and applied it to four vertebrate genomes. For each genome, we corrected mis-assemblies, improved estimates of the amount of duplicated sequence, and recovered polymorphisms between the sequenced chromosomes. PMID:20219098

  6. Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis

    NARCIS (Netherlands)

    Kiryluk, Krzysztof; Li, Yifu; Sanna-Cherchi, Simone; Rohanizadegan, Mersedeh; Suzuki, Hitoshi; Eitner, Frank; Snyder, Holly J.; Choi, Murim; Hou, Ping; Scolari, Francesco; Izzi, Claudia; Gigante, Maddalena; Gesualdo, Loreto; Savoldi, Silvana; Amoroso, Antonio; Cusi, Daniele; Zamboli, Pasquale; Julian, Bruce A.; Novak, Jan; Wyatt, Robert J.; Mucha, Krzysztof; Perola, Markus; Kristiansson, Kati; Viktorin, Alexander; Magnusson, Patrik K.; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Stefansson, Kari; Boland, Anne; Metzger, Marie; Thibaudin, Lise; Wanner, Christoph; Jager, Kitty J.; Goto, Shin; Maixnerova, Dita; Karnib, Hussein H.; Nagy, Judit; Panzer, Ulf; Xie, Jingyuan; Chen, Nan; Tesar, Vladimir; Narita, Ichiei; Berthoux, Francois; Floege, Jürgen; Stengel, Benedicte; Zhang, Hong; Lifton, Richard P.; Gharavi, Ali G.

    2012-01-01

    IgA nephropathy (IgAN), major cause of kidney failure worldwide, is common in Asians, moderately prevalent in Europeans, and rare in Africans. It is not known if these differences represent variation in genes, environment, or ascertainment. In a recent GWAS, we localized five IgAN susceptibility

  7. Climate and vegetation since the Last Interglacial (MIS 5e) in a putative glacial refugium, northern Idaho, USA

    Science.gov (United States)

    Herring, Erin M.; Gavin, Daniel G.

    2015-06-01

    There are very few terrestrial sediment records from North America that contain a nearly continuous sequence spanning from the Last Interglacial period to the present. We present stratigraphic records of pollen and several other proxies from a Carex-dominated wetland, Star Meadows, located 140 km south of the maximum extent of the Cordilleran Ice Sheet and near the current southern extent of interior mesic forests in northern Idaho. Many species in this region are disjunct by 160 km of arid steppe and dry forest from their more extensive distribution along the Pacific Northwest coast and may have survived in an interior refugium. The chronology for the upper 251 cm was determined by six radiocarbon dates and one tephra deposit, and the age of the remainder of the core (251-809 cm) was estimated by correlation with SPECMAP δ18O. Fluctuating water levels were inferred from alternating peat, biogenic silica, and aquatic pollen types. During MIS 5e the region was warmer and drier than today and was dominated by Pinus (likely Pinus contorta) mixed conifer forest surrounding a Carex meadow. A cool-moist climate (MIS 5b-5d) soon developed, and the site was inundated with deep water. Pollen indicated wetland vegetation (Betula glandulosa, Typhaceae, and Salix) developed around a lake with a Pseudotsuga/Larix and Picea forest on the surrounding slopes. During MIS 5a, a warmer climate supported a Pseudotsuga/Larix, Abies, and Picea forest on the surrounding hillsides and a Carex-dominated environment within a dry meadow. From MIS 4 to MIS 3, a cool and wet Pinus and Picea forest predominated. Water levels rose, enabling Nuphar to persist within a perennial lake while a sedge fen established along the lake margin. As climate transitioned into MIS 2, a cooler and drier climate supported a Pinus and Picea subalpine parkland, though water levels remained high enough to support Nuphar. During the Last Glacial Maximum the sediment was mainly silt and clay with high Artemisia and

  8. Plasma Gelsolin Promotes Proliferation of Mesangial Cell in IgA Nephropathy

    Directory of Open Access Journals (Sweden)

    Lei Zhang

    2016-12-01

    Full Text Available Background/Aims: Plasma gelsolin (pGSN is an actin-binding protein that plays a critical role in the pathogenesis of rheumatoid arthritis. However, whether pGSN is involved in other immunological diseases remains unknown. This study focused on the relationship between pGSN and immunoglobulin A (IgA nephropathy (IgAN. Methods: Two hundred patients with IgAN, 200 patients each with several other types of nephropathy and healthy controls (HCs who underwent kidney biopsies between 2000 and 2014 were enrolled in the study. The Oxford classification system was used to predict the risk of disease progression. Serum and renal tissue were used to detect pGSN, and the correlations between pGSN and IgA, galactose-deficient IgA1 (Gd-IgA1, transforming growth factor beta1 (TGF-β1, fibronectin (FN content, clinical symptoms, and kidney function were analyzed. Results: We found that the pGSN levels were significantly decreased in sera from IgAN patients compared to sera from patients with other forms of glomerular nephritis and HCs. Furthermore, the serum pGSN levels were negatively correlated with the serum IgA1, FN, and TGF-β1 levels, and positively correlated with the estimated glomerular filtration rate. Conversely, the glomerular pGSN content was significantly elevated in the IgAN patients and was positively correlated with TGF-β1 and FN levels. In renal tissue, the pGSN levels were significantly higher in IgAN patients with M1 and S1 compared to patients with M0 and S0 (p in vitro. pGSN also promoted integrin α2β1 expression in HMCs and enhanced the integrin α2β1-pGSN interaction. Conclusion: Our study suggested that pGSN may play an important role in the development of IgAN by promoting the proliferation of mesangial cells and that serum and glomerular pGSN levels may be new markers for predicting IgAN progression and prognosis.

  9. ERP ehk tarkvara, mis teab ja teeb kõike / Kadri Põdra, Randel Uibo, Heiti Kender

    Index Scriptorium Estoniae

    Põdra, Kadri

    2006-01-01

    ERP (Enterprise Resource Planning) on majandustarkvara, mis võimaldab hallata ühtses süsteemis ettevõtte kõiki majandusandmeid ja äriprotsesse. Uuringufirma Faktum & Ariko poolt 2005. a. detsembris tehtud uuringust ERP-süsteemide kasutamise kohta Eesti suurettevõtetes. Lisatud statistilised diagrammid

  10. Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity.

    Directory of Open Access Journals (Sweden)

    Yuanjie Hu

    Full Text Available Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 (Chr7 copy number variation (CNV in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in gliomas, with a higher percentage of cells in high-grade gliomas carrying more than 2 copies of Chr7, as compared to low-grade gliomas. Interestingly, all Chr7-aneuploid cell types in the parental culture of established glioma cell lines reappeared in single-cell-derived subcultures. We then characterized the biology of three syngeneic glioma cultures dominated by different Chr7-aneuploid cell types. We found phenotypic divergence for cells following Chr7 mis-segregation, which benefited overall tumor growth in vitro and in vivo. Mathematical modeling suggested the involvement of chromosome instability and interactions among cell subpopulations in restoring the optimal equilibrium of tumor cell types. Both our experimental data and mathematical modeling demonstrated that the complexity of tumor heterogeneity could be enhanced by the existence of chromosomes with structural abnormality, in addition to their mis-segregations. Overall, our findings show, for the first time, the involvement of chromosome instability in maintaining tumor heterogeneity, which underlies the enhanced growth, persistence and treatment resistance of cancers.

  11. Childhood (Mis)Fortune, Educational Attainment, and Adult Health: Contingent Benefits of a College Degree?

    Science.gov (United States)

    Schafer, Markus H.; Wilkinson, Lindsay R.; Ferraro, Kenneth F.

    2013-01-01

    College-educated adults are healthier than other people in the United States, but selection bias complicates our understanding of how education influences health. This article focuses on the possibility that the health benefits of college may vary according to childhood (mis)fortune and people's propensity to attain a college degree in the first…

  12. Interest (mis)alignments in representative negotiations: Do pro-social agents fuel or reduce inter-group conflict?

    NARCIS (Netherlands)

    Aaldering, H.; Greer, L.L.; van Kleef, G.A.; de Dreu, C.K.W.

    2013-01-01

    In representative negotiations, interests of the representative and the represented constituency are not always aligned. We investigated how interest (mis)alignment and representative’s social value orientation influence representative negotiations. Past theory and research on the principal-agent

  13. Gluten exacerbates IgA nephropathy in humanized mice through gliadin-CD89 interaction.

    Science.gov (United States)

    Papista, Christina; Lechner, Sebastian; Ben Mkaddem, Sanae; LeStang, Marie-Bénédicte; Abbad, Lilia; Bex-Coudrat, Julie; Pillebout, Evangéline; Chemouny, Jonathan M; Jablonski, Mathieu; Flamant, Martin; Daugas, Eric; Vrtovsnik, François; Yiangou, Minas; Berthelot, Laureline; Monteiro, Renato C

    2015-08-01

    IgA1 complexes containing deglycosylated IgA1, IgG autoantibodies, and a soluble form of the IgA receptor (sCD89), are hallmarks of IgA nephropathy (IgAN). Food antigens, notably gluten, are associated with increased mucosal response and IgAN onset, but their implication in the pathology remains unknown. Here, an IgAN mouse model expressing human IgA1 and CD89 was used to examine the role of gluten in IgAN. Mice were given a gluten-free diet for three generations to produce gluten sensitivity, and then challenged for 30 days with a gluten diet. A gluten-free diet resulted in a decrease of mesangial IgA1 deposits, transferrin 1 receptor, and transglutaminase 2 expression, as well as hematuria. Mice on a gluten-free diet lacked IgA1-sCD89 complexes in serum and kidney eluates. Disease severity depended on gluten and CD89, as shown by reappearance of IgAN features in mice on a gluten diet and by direct binding of the gluten-subcomponent gliadin to sCD89. A gluten diet exacerbated intestinal IgA1 secretion, inflammation, and villous atrophy, and increased serum IgA1 anti-gliadin antibodies, which correlated with proteinuria in mice and patients. Moreover, early treatment of humanized mice with a gluten-free diet prevented mesangial IgA1 deposits and hematuria. Thus, gliadin-CD89 interaction may aggravate IgAN development through induction of IgA1-sCD89 complex formation and a mucosal immune response. Hence, early-stage treatment with a gluten-free diet could be beneficial to prevent disease.

  14. Pathological interstitial vascular proliferation adjacent to glomeruli in immunoglobulin a nephropathy

    Directory of Open Access Journals (Sweden)

    Honami Mori

    2016-01-01

    Full Text Available We detected an increase in small arterioles around glomeruli, particularly adjacent to tuft adhesive lesions in immunoglobulin A nephropathy (IgAN, for the 1 st time, as far as we know. We labeled these as periglomerular microarterioles (PGMAs. This study aimed to clarify the pathological significance of PGMAs. Sixty-two patients with IgAN and 19 controls with minor glomerular abnormalities without proteinuria were evaluated in this study. The number of PGMAs located between the Bowman′s capsule and the adjoining tubules was counted for each glomerulus. The mean number of PGMAs per glomerulus in cases of IgAN was significantly higher than those of the controls (0.530 ± 0.477 vs. 0.240 ± 0.182, P <0.05. Serial sections showed that most of the PGMAs were in contact with adjacent glomeruli (71.8%, through tuft adhesive lesions (52.1%, or the vascular pole (19.7%. By single regression analysis, the number of PGMAs was found to be positively correlated with the incidence of glomerular tuft adhesion, glomerular sclerosis, or the area of interstitial fibrosis in IgAN. By multiple regression analysis, the incidence of glomerular tuft adhesion was found to be the only independent pathological feature to correlate with the number of PGMAs (P = 0.0006. We have noticed the existence of PGMAs around glomeruli as a pathological finding of IgAN. Furthermore, the number of PGMAs was associated with the incidence of tuft adhesive lesion in glomeruli of IgAN although there was no relationship between the presence of PGMAs and clinical parameters including urinary protein excretion or creatinine clearance in the present study.

  15. Timing of the onset of MIS 11 revealed by speleothem in southern Europe

    Science.gov (United States)

    Hu, Hsun-Ming; Shen, Chuan-Chou; Michel, Véronique; Kano, Akihiro

    2017-04-01

    The interglacial period, known as Marine Isotope Stage 11 (MIS 11, 428-397 thousand years ago), is often considered as a potential analogue for future climate projection because of the similar patterns of insolation variability. However, studies on mechanisms of the onset of MIS 11 (called Termination V, T-V) in response to insolation increase is still hampered by a lack of good dating materials in paleoclimate archives, despite a stack of East Asian monsoon records with precise U-Th dates has been proposed. Previous studies suggested the δ18O value registered in speleothems in Mediterranean realm can be a good bridge connecting the U-Th-based age model of speleothem to marine cores from Mediterranean sea, which opens a new possibility to detect ocean-atmosphere/internal-external forcing interaction beyond 14C dating limitation. Here we present a new speleothem δ18O record from northern Italy covering 500-300 thousand years ago. The results show a similar pattern with δ18O records of marine cores around Mediterranean. The age model of the speleothem hence provides an opportunity for tuning the marine cores, which could improve our understanding of relationship between global atmosphere and ocean circulations.

  16. Preparation and dielectric investigation of organic metal insulator semiconductor (MIS) structures with a ferroelectric polymer

    Energy Technology Data Exchange (ETDEWEB)

    Kalbitz, Rene; Fruebing, Peter; Gerhard, Reimund [Department of Physics and Astronomy, University of Potsdam (Germany); Taylor, Martin [School of Electronic Engineering, Bangor University (United Kingdom)

    2010-07-01

    Ferroelectric field effect transistors (FeFETs) offer the prospect of an organic-based memory device. Since the charge transport in the semiconductor is confined to the interface region between the insulator and the semiconductor, the focus of the present study was on the investigation of this region in metal-insulator-semiconductor (MIS) capacitors using dielectric spectroscopy. Capacitance-Voltage (C-V) measurements at different frequencies as well as capacitance-frequency (C-f) measurements after applying different poling voltages were carried out. The C-V measurements yielded information about the frequency dependence of the depletion layer width as well as the number of charges stored at the semiconductor/ insulator interface. The results are compared to numerical calculations based on a model introduced by S. L. Miller (JAP, 72(12), 1992). The C-f measurements revealed three main relaxation processes. An equivalent circuit has been developed to model the frequency response of the MIS capacitor. With this model the origin of the three relaxations may be deduced.

  17. Analysis of frequency-dependent series resistance and interface states of In/SiO{sub 2}/p-Si (MIS) structures

    Energy Technology Data Exchange (ETDEWEB)

    Birkan Selcuk, A. [Department of Nuclear Electronics and Instrumentation, Saraykoey Nuclear Research and Training Center, 06983 Saray, Ankara (Turkey); Tugluoglu, N. [Department of Nuclear Electronics and Instrumentation, Saraykoey Nuclear Research and Training Center, 06983 Saray, Ankara (Turkey)], E-mail: ntuglu@taek.gov.tr; Karadeniz, S.; Bilge Ocak, S. [Department of Nuclear Electronics and Instrumentation, Saraykoey Nuclear Research and Training Center, 06983 Saray, Ankara (Turkey)

    2007-11-15

    In this work, the investigation of the interface state density and series resistance from capacitance-voltage (C-V) and conductance-voltage (G/{omega}-V) characteristics in In/SiO{sub 2}/p-Si metal-insulator-semiconductor (MIS) structures with thin interfacial insulator layer have been reported. The thickness of SiO{sub 2} film obtained from the measurement of the oxide capacitance corrected for series resistance in the strong accumulation region is 220 A. The forward and reverse bias C-V and G/{omega}-V characteristics of MIS structures have been studied at the frequency range 30 kHz-1 MHz at room temperature. The frequency dispersion in capacitance and conductance can be interpreted in terms of the series resistance (R{sub s}) and interface state density (D{sub it}) values. Both the series resistance R{sub s} and density of interface states D{sub it} are strongly frequency-dependent and decrease with increasing frequency. The distribution profile of R{sub s}-V gives a peak at low frequencies in the depletion region and disappears with increasing frequency. Experimental results show that the interfacial polarization contributes to the improvement of the dielectric properties of In/SiO{sub 2}/p-Si MIS structures. The interface state density value of In/SiO{sub 2}/p-Si MIS diode calculated at strong accumulation region is 1.11x10{sup 12} eV{sup -1} cm{sup -2} at 1 MHz. It is found that the calculated value of D{sub it} ({approx}10{sup 12} eV{sup -1} cm{sup -2}) is not high enough to pin the Fermi level of the Si substrate disrupting the device operation.

  18. Comparison of degree of postoperative muscle damage between MIS-TLIF- and PLIF treatment for single-level degenerative lumbar disease

    Directory of Open Access Journals (Sweden)

    Liang ZHOU

    2014-01-01

    Full Text Available Objective To compare the postoperative muscle damage after either posterior lumbar interbody fusion (PLIF or minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF with the aid of X-Tube system in patients with singlelevel degenerative lumbar spinal disease. Methods The clinical data of 52 patients (males 28, females 24, aged 54.3±7.8 years with single-level degenerative lumbar spinal disease undergoing MIS-TLIF assisted by the X-Tube system from Oct 2010 to Sep 2011 was analyzed retrospectively. The operative time, intraoperative blood loss, postoperative drainage volume, postoperative bedtime, and serum creatine kinase (CK level 1 day before surgery and 1, 3 and 5 days after surgery were recorded and compared with those of 38 patients (males 20, females 18, aged 51.6±8.6 years with the same disease undergoing conventional open PLIF during the corresponding period. The back pain visual analogue score (VAS, Oswestry disability index (ODI score and imaging examination were performed before operation, after operation and during follow-up duration for each patient. Results There was no significant difference in the gender, age, clinical diagnosis, lesion location, preoperative CK level, VAS and ODI scores between the two groups (P>0.05. The operative time was longer in MIS-TLIF group than in PLIF group (P0.05. Radiological followup observation revealed good fusion 6 months after operation in all the patients. Conclusion The X-Tube-assisted MIS-TLIF has several advantages over conventional open PLIF, such as less intraoperative blood loss, milder muscle damage, and lighter back pain. DOI: 10.11855/j.issn.0577-7402.2013.12.04

  19. Race/ethnicity and disease severity in IgA nephropathy

    Directory of Open Access Journals (Sweden)

    Chertow Glenn M

    2004-09-01

    Full Text Available Abstract Background Relatively few U.S.-based studies in chronic kidney disease have focused on Asian/Pacific Islanders. Clinical reports suggest that Asian/Pacific Islanders are more likely to be affected by IgA nephropathy (IgAN, and that the severity of disease is increased in these populations. Methods To explore whether these observations are borne out in a multi-ethnic, tertiary care renal pathology practice, we examined clinical and pathologic data on 298 patients with primary glomerular lesions (IgAN, focal segmental glomerulosclerosis, membranous nephropathy and minimal change disease at the University of California San Francisco Medical Center from November 1994 through May 2001. Pathologic assessment of native kidney biopsies with IgAN was conducted using Haas' classification system. Results Among individuals with IgAN (N = 149, 89 (60% were male, 57 (38% white, 53 (36% Asian/Pacific Islander, 29 (19% Hispanic, 4 (3% African American and 6 (4% were of other or unknown ethnicity. The mean age was 37 ± 14 years and median serum creatinine 1.7 mg/dL. Sixty-six patients (44% exhibited nephrotic range proteinuria at the time of kidney biopsy. The distributions of age, gender, mean serum creatinine, and presence or absence of nephrotic proteinuria and/or hypertension at the time of kidney biopsy were not significantly different among white, Hispanic, and Asian/Pacific Islander groups. Of the 124 native kidney biopsies with IgAN, 10 (8% cases were classified into Haas subclass I, 12 (10% subclass II, 23 (18% subclass III, 30 (25% subclass IV, and 49 (40% subclass V. The distribution of Haas subclass did not differ significantly by race/ethnicity. In comparison, among the random sample of patients with non-IgAN glomerular lesions (N = 149, 77 (52% patients were male, 51 (34% white, 42 (28% Asian/Pacific Islander, 25 (17% Hispanic, and 30 (20% were African American. Conclusions With the caveats of referral and biopsy biases, the race

  20. Modelling silicon supply during the Last Interglacial (MIS 5e) at Lake Baikal

    Science.gov (United States)

    Panizzo, V. N.; Swann, G. E. A.; Mackay, A. W.; Pashley, V.; Horstwood, M. S. A.

    2018-06-01

    Limnological reconstructions of primary productivity have demonstrated its response over Quaternary timescales to drivers such as climate change, landscape evolution and lake ontogeny. In particular, sediments from Lake Baikal, Siberia, provide a valuable uninterrupted and continuous sequence of biogenic silica (BSi) records, which document orbital and sub-orbital frequencies of regional climate change. We here extend these records via the application of stable isotope analysis of silica in diatom opal (δ30Sidiatom) from sediments covering the Last Interglacial cycle (Marine Isotope Stage [MIS] 5e; c. 130 to 115 ka BP) as a means to test the hypothesis that it was more productive than the Holocene. δ30Sidiatom data for the Last Interglacial range between +1.29 and +1.78‰, with highest values between c. 127 to 124 ka BP (+1.57 to +1.78‰). Results show that diatom dissolved silicon (DSi) utilisation, was significantly higher (p = 0.001) during MIS 5e than the current interglacial, which reflects increased diatom productivity over this time (concomitant with high diatom biovolume accumulation rates [BVAR] and warmer pollen-inferred vegetation reconstructions). Diatom BVAR are used, in tandem with δ30Sidiatom data, to model DSi supply to Lake Baikal surface waters, which shows that highest delivery was between c. 123 to 120 ka BP (reaching peak supply at c. 120 ka BP). When constrained by sedimentary mineralogical archives of catchment weathering indices (e.g. the Hydrolysis Index), data highlight the small degree of weathering intensity and therefore representation that catchment-weathering DSi sources had, over the duration of MIS 5e. Changes to DSi supply are therefore attributed to variations in within-lake conditions (e.g. turbulent mixing) over the period, where periods of both high productivity and modelled-DSi supply (e.g. strong convective mixing) account for the decreasing trend in δ30Sidiatom compositions (after c. 124 ka BP).

  1. A Modified Protocol with Improved Detection Rate for Mis-Matched Donor HLA from Low Quantities of DNA in Urine Samples from Kidney Graft Recipients.

    Directory of Open Access Journals (Sweden)

    Janette Kwok

    Full Text Available Urine from kidney transplant recipient has proven to be a viable source for donor DNA. However, an optimized protocol would be required to determine mis-matched donor HLA specificities in view of the scarcity of DNA obtained in some cases.In this study, fresh early morning urine specimens were obtained from 155 kidney transplant recipients with known donor HLA phenotype. DNA was extracted and typing of HLA-A, B and DRB1 loci by polymerase chain reaction-specific sequence primers was performed using tailor-made condition according to the concentration of extracted DNA.HLA typing of DNA extracted from urine revealed both recipient and donor HLA phenotypes, allowing the deduction of the unknown donor HLA and hence the degree of HLA mis-match. By adopting the modified procedures, mis-matched donor HLA phenotypes were successfully deduced in all of 35 tested urine samples at DNA quantities spanning the range of 620-24,000 ng.This urine-based method offers a promising and reliable non-invasive means for the identification of mis-matched donor HLA antigens in kidney transplant recipients with unknown donor HLA phenotype or otherwise inadequate donor information.

  2. Gastrointestinal sensitivity to soy and milk proteins in patients with IgA nephropathy.

    Science.gov (United States)

    Kloster Smerud, H; Fellström, B; Hällgren, R; Osagie, S; Venge, P; Kristjánsson, G

    2010-11-01

    sensitivity to food antigens has been postulated as a contributing factor to the pathogenesis of IgA nephropathy (IgAN). in this study we used a recently developed mucosal patch technique to evaluate rectal mucosal sensitivity to soy and cow's milk (CM) proteins in IgAN patients (n = 28) compared to healthy subjects (n = 18). The rectal mucosal production of nitric oxide (NO) and release of myeloperoxidase (MPO) and eosinophil cationic protein (ECP) were measured. Serum samples were analyzed for IgA and IgG antibodies to alpha-lactalbumin, beta-lactoglobulin, casein and soy. 14 of 28 (14/28) patients experienced a rectal mucosal reaction, measured by increased NO and/or MPO levels, upon rectal challenge with soy and/or cow's milk proteins. The levels of IgG antibodies to alpha-lactalbumin, beta-lactoglobulin and casein were significantly higher in CM sensitive as compared with non-sensitive IgAN patients, whereas the mean serum levels of IgA antibodies were similar. No differences were seen in serum levels of IgA or IgG antibodies to soy. it is concluded that approximately half of our IgAN patients have a rectal mucosal sensitivity to soy or CM, and that an immune reactivity against antigens may be involved in the pathogenesis of IgAN in this subgroup of patients.

  3. Uncoupling of glomerular IgA deposition and disease progression in alymphoplasia mice with IgA nephropathy.

    Directory of Open Access Journals (Sweden)

    Masashi Aizawa

    Full Text Available Previous clinical and experimental studies have indicated that cells responsible for IgA nephropathy (IgAN, at least in part, are localized in bone marrow (BM. Indeed, we have demonstrated that murine IgAN can be experimentally reconstituted by bone marrow transplantation (BMT from IgAN prone mice in not only normal mice, but also in alymphoplasia mice (aly/aly independent of IgA+ cells homing to mucosa or secondary lymphoid tissues. The objective of the present study was to further assess whether secondary lymph nodes (LN contribute to the progression of this disease. BM cells from the several lines of IgAN prone mice were transplanted into aly/aly and wild-type mice (B6. Although the transplanted aly/aly showed the same degree of mesangial IgA and IgG deposition and the same serum elevation levels of IgA and IgA-IgG immune-complexes (IC as B6, even in extent, the progression of glomerular injury was observed only in B6. This uncoupling in aly/aly was associated with a lack of CD4+ T cells and macrophage infiltration, although phlogogenic capacity to nephritogenic IC of renal resident cells was identical between both recipients. It is suggested that secondary LN may be required for the full progression of IgAN after nephritogenic IgA and IgA/IgG IC deposition.

  4. Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease.

    Science.gov (United States)

    Julayanont, Parunyou; Brousseau, Mélanie; Chertkow, Howard; Phillips, Natalie; Nasreddine, Ziad S

    2014-04-01

    To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). Retrospective chart review. Community-based memory clinic. Individuals meeting Petersen's MCI criteria (N = 165). Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD. One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%). Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD. © 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.

  5. A Study of the Subject Categorization of the MIS-related Journals in the ISI Databases Using Topical Features in the Text Content and Machine Learning Methods

    Directory of Open Access Journals (Sweden)

    Sung-Chien Lin

    2015-07-01

    Full Text Available In this study we analyzed and discussed that the MIS-related journals under the ISI subject category of IS&LS are simultaneously given with subject category Management, using methods of topic modeling, journal clustering and subject category prediction. In the experiment of journal clustering, all journals under subject category Management and other journals also having similar topical features can be gathered into a cluster, and “management” is their common and the most distinct topic. Because the journals belonged to this cluster are almost same to those in the MIS clusters generated by the previous studies, we considered it as the MIS cluster in this study. In the second experiment, we used the classification and regression tree (CART technique to predict assignment of subject category with that the journals in the original subject category Management and in the MIS cluster produced in this study as positive examples, respectively. The trees generated by the two tests both used the occurring probabilities of the topic “management” as the main classification rule. However, in the latter test, we did not only obtain a simpler classification tree but also had a result with less predicting errors. This means that if all journals in the MIS cluster could be given with subject category Management, the retrieval results can be more effective and complete.

  6. The effects of frequency and {gamma}-irradiation on the dielectric properties of MIS type Schottky diodes

    Energy Technology Data Exchange (ETDEWEB)

    Tataroglu, A. [Department of Physics, Faculty of Arts and Sciences, Teknikokullar, Gazi University, 06500 Ankara (Turkey)]. E-mail: ademt@gazi.edu.tr; Altindal, S. [Department of Physics, Faculty of Arts and Sciences, Teknikokullar, Gazi University, 06500 Ankara (Turkey)

    2007-01-15

    The effects of {gamma}-irradiation on the dielectric properties of Al/SiO{sub 2}/p-Si (MIS) Schottky diodes were investigated using capacitance-voltage (C-V) and conductance-voltage (G/{omega}-V) characteristics. Before irradiation, the C-V and G/{omega}-V characteristics were measured by applying a small ac signal of 50 mV amplitude and 100 Hz-1 MHz frequencies, while the dc voltage was swept from positive bias to negative bias for MIS Schottky diodes. Afterwards, the C-V and G/{omega}-V measurements carried out at various radiation doses and 1 MHz. The MIS Schottky diodes were exposed to a {sup 60}Co {gamma}-radiation source at a dose of 2.12 kGy/h and the total dose range was from zero to 450 kGy. The dielectric constant ({epsilon}'), dielectric loss ({epsilon}''), loss tangent (tan {delta}) and ac electrical conductivity ({sigma} {sub ac}) were calculated from the C-V and G/{omega}-V measurements and plotted as a function of frequency and radiation dose. Experimental results show that the {epsilon}' and {epsilon}'' were found to decrease with increasing frequency while increase with increasing radiation dose. In addition, tan {delta} versus log f show a peak, which was not present in the tan {delta} versus radiation dose. Also, the {sigma} {sub ac} is found to increase with increasing radiation dose. These changes were attributed to mobile charge carriers or dipolar molecules generated by structural changes in the irradiated samples.

  7. Infrared stimulated luminescence dating of an Eemian (MIS 5e) site in Denmark using K-feldspar

    DEFF Research Database (Denmark)

    Buylaert, Jan-Pieter; Huot, Sebastian; Murray, Andrew S.

    2011-01-01

    Infrared stimulated luminescence (IRSL) dating of K-feldspars may be an alternative to quartz optically stimulated luminescence (OSL) dating when the quartz OSL signal is too close to saturation or when the quartz luminescence characteristics are unsuitable. In this paper, Eemian (MIS 5e) coastal...

  8. Combined blockade of angiotensin II and prorenin receptors ameliorates podocytic apoptosis induced by IgA-activated mesangial cells.

    Science.gov (United States)

    Leung, Joseph C K; Chan, Loretta Y Y; Saleem, M A; Mathieson, P W; Tang, Sydney C W; Lai, Kar Neng

    2015-07-01

    Glomerulo-podocytic communication plays an important role in the podocytic injury in IgA nephropathy (IgAN). In this study, we examine the role of podocytic angiotensin II receptor subtype 1 (AT1R) and prorenin receptor (PRR) in podocytic apoptosis in IgAN. Polymeric IgA (pIgA) was isolated from patients with IgAN and healthy controls. Conditioned media were prepared from growth arrested human mesangial cells (HMC) incubated with pIgA from patients with IgAN (IgA-HMC media) or healthy controls (Ctl-HMC media). A human podocyte cell line was used as a model to examine the regulation of the expression of AT1R, PRR, TNF-α and CTGF by IgA-HMC media. Podocytic nephrin expression, annexin V binding and caspase 3 activity were used as the functional readout of podocytic apoptosis. IgA-HMC media had no effect on AngII release by podocytes. IgA-HMC media significantly up-regulated the expression of AT1R and PRR, down-regulated nephrin expression and induced apoptosis in podocytes. Mono-blockade of AT1R, PRR, TNF-α or CTGF partially reduced podocytic apoptosis. IgA-HMC media activated NFκB, notch1 and HEY1 expression by podocytes and dual blockade of AT1R with PRR, or anti-TNF-α with anti-CTGF, effectively rescued the podocytic apoptosis induced by IgA-HMC media. Our data suggests that pIgA-activated HMC up-regulates the expression of AT1R and PRR expression by podocytes and the associated activation of NFκB and notch signalling pathways play an essential role in the podocytic apoptosis induced by glomerulo-podocytic communication in IgAN. Simultaneously targeting the AT1R and PRR could be a potential therapeutic option to reduce the podocytic injury in IgAN.

  9. The gut-kidney axis in IgA nephropathy: role of microbiota and diet on genetic predisposition.

    Science.gov (United States)

    Coppo, Rosanna

    2018-01-01

    Recent data suggest that gut-associated lymphoid tissue (GALT) plays a major role in the development of immunoglobulin A (IgA) nephropathy (IgAN). A genome-wide association study showed that most loci associated with the risk of IgAN are also associated with immune-mediated inflammatory bowel diseases, maintenance of the intestinal barrier and regulation of response to gut pathogens. Studies involving experimental models have demonstrated a pivotal role of intestinal microbiota in the development of IgAN in mice producing high levels of IgA and in transgenic mice overexpressing BAFF, a B-cell factor crucial for IgA synthesis, indicating the role of genetic background, B-cell activity, GALT intestinal immunity and diet. The effect of diet was suggested by pilot studies carried out 30 years ago which showed that a gluten-rich diet induced IgAN in mice and that some patients benefited from a gluten-free diet. A recent experimental model in mice expressing human IgA1 and Fc alpha receptor CD89 reported clinical and histological improvement after a gluten-free diet. Clinical observations have elicited new interest in GALT hyper-reactivity in IgAN patients. In a pilot study, a reduction in proteinuria was attained using an enteric controlled-release formulation of the corticosteroid budesonide targeted to the Peyer's patches at the ileocecal junction. This formulation was tested in the placebo-controlled NEFIGAN phase 2b trial, with a reduction in proteinuria after 9 months of treatment together with stabilization of renal function in patients with persistent proteinuria. In conclusion, the gut-kidney axis modulated by microbiota and diet is a promising target for focused treatment of IgAN in genetically predisposed patients at risk of progression.

  10. Association between polymorphisms in Interleukin-17 receptor A gene and childhood IgA nephropathy

    Directory of Open Access Journals (Sweden)

    Seung-Ah Baek

    2010-02-01

    Full Text Available Purpose : Interleukin-17 (IL-17 is produced by activated CD4+T cells and exhibits pleiotropic biological activity on various cell types. IL-17 was reported to be involved in the immunoregulatory response in IgA nephropathy (IgAN. Our aim was to investigate the association between single-nucleotide polymorphisms (SNPs in IL-17 receptor A (IL-17RA gene and childhood IgAN. Methods : We analyzed the SNPs in the IL-17RA in 156 children with biopsy-proven IgAN and 245 healthy controls. We divided the IgAN patients into 2 groups and compared them with respect to proteinuria (?#180; and &gt;4 mg/m2/h, ?#180;0 and &gt;40 mg/m2/h, respectively and the presence of pathological levels of biomarkers of diseases such as interstitial fibrosis, tubular atrophy, or global sclerosis. Results : No difference was observed between the SNP genotypes rs2895332, rs1468488, and rs4819553 between IgAN patients and control subjects. In addition, no significant difference was observed between allele frequency of SNPs rs2895 332, rs1468488, and rs4819553 between patients in the early and advanced stage of the disease. However, significant difference was observed between the genotype of SNP rs2895332 between patients with proteinuria (&gt;4 mg/m2/h and those without proteinuria (codominant model OR 0.36, 95% CI 0.19&#8211;0.66, P&lt;0.001; dominant model OR 0.35, 95% CI 0.17&#8211;0.69 P=0.002; recessive model OR 0.12, 95% CI 0.01&#8211;1.06 P=0.025. Conclusion : Our results indicate that the SNP in IL-17RA (rs2895332 may be related to the development of proteinuria in IgAN patients.

  11. Collapsing glomerulopathy following anabolic steroid use in a 16-year-old boy with IgA nephropathy

    Directory of Open Access Journals (Sweden)

    S M Matthai

    2015-01-01

    Full Text Available Collapsing glomerulopathy (CG is a proliferative podocytopathy, increasingly recognized in a variety of disease conditions. We report a case of CG in a 16-year-old boy with IgA nephropathy (IgAN who presented with acute kidney injury, marked proteinuria and hypertension following a short period of anabolic steroid use. Although CG has been associated with long-term anabolic steroid use among body builders, there is no data on the effect of anabolic steroid use in persons with underlying renal disease like IgAN. We postulate that development of CG in our patient could be temporally linked to intake of body-building steroids along with a predisposing background renal disease of IgAN.

  12. Mechanism of leakage of ion-implantation isolated AlGaN/GaN MIS-high electron mobility transistors on Si substrate

    Science.gov (United States)

    Zhang, Zhili; Song, Liang; Li, Weiyi; Fu, Kai; Yu, Guohao; Zhang, Xiaodong; Fan, Yaming; Deng, Xuguang; Li, Shuiming; Sun, Shichuang; Li, Xiajun; Yuan, Jie; Sun, Qian; Dong, Zhihua; Cai, Yong; Zhang, Baoshun

    2017-08-01

    In this paper, we systematically investigated the leakage mechanism of the ion-implantation isolated AlGaN/GaN metal-insulator-semiconductor high electron mobility transistors (MIS-HEMTs) on Si substrate. By means of combined DC tests at different temperatures and electric field dependence, we demonstrated the following original results: (1) It is proved that gate leakage is the main contribution to OFF-state leakage of ion-implantation isolated AlGaN/GaN MIS-HEMTs, and the gate leakage path is a series connection of the gate dielectric Si3N4 and Si3N4-GaN interface. (2) The dominant mechanisms of the leakage current through LPCVD-Si3N4 gate dielectric and Si3N4-GaN interface are identified to be Frenkel-Poole emission and two-dimensional variable range hopping (2D-VRH), respectively. (3) A certain temperature annealing could reduce the density of the interface state that produced by ion implantation, and consequently suppress the interface leakage transport, which results in a decrease in OFF-state leakage current of ion-implantation isolated AlGaN/GaN MIS-HEMTs.

  13. Effect of surface states on electrical characteristic of metal - insulator - semiconductor (MIS) diodes

    International Nuclear Information System (INIS)

    Altindal, S.; Doekme, I.; Tataroglu, A.; Sahingoez, R.

    2002-01-01

    The current-voltage (I-V) characteristics of Metal-Insulator-Semiconductor (MIS) Schottky barrier diodes which is consider distribution of interface states in equilibrium with semiconductor were determined at two (low and high) temperature. The interface states were responsible for non-ideal behavior of the forward I-V characteristic of diodes. Both diodes (n and p type Si) showed non-ideal behavior with an ideality factor 1.6 and 1.85 respectively at room temperature. The higher values of n-type Si were attributed to an order of magnitude higher density of interface states in the both diodes. The effect of an interfacial insulator layer between the metal and semiconductor are also studied. The high density of interface states also caused a reduction in the barrier height of the MIS diode. It is shown that by using Norde function at low and high temperature, barrier height □ b , series resistance R s and ideality factor n can be determined even in the case 1 s obtained from Norde function strongly depend on temperature, and decrease with increasing temperature. In addition, the potential barrier height increases with increasing temperature. The mean density of interface states N ss decreases with increasing temperature. Particularly at low temperature the I-V characteristics are controlled by interface states density

  14. Properties of MIS structures based on graded-gap HgCdTe grown by molecular beam epitaxy

    International Nuclear Information System (INIS)

    Voitsekhovskii, A. V.; Nesmelov, S. N.; Dzyadookh, S. M.; Varavin, V. S.; Dvoretskii, S. A.; Mikhailov, N. N.; Sidorov, Yu. G.; Vasiliev, V. V.

    2008-01-01

    The effect of near-surface graded-gap layers on the electrical characteristics of MIS structures fabricated based on heteroepitaxial Hg 1-x Cd x Te films grown by molecular beam epitaxy with a two-layer SiO 2 /Si 3 N 4 insulator and anodic oxide film is studied experimentally. It is shown that a larger modulation of capacitance (depth and width of the valley) is observed compared with the structures without the graded-gap layer. The field dependences of photovoltage of MIS structures with the graded-gap layers had a classical form and were characterized by a drop only in the enrichment region. For the structures without the graded-gap layer with x = 0.22, a drop in the voltage dependence of the photocurrent is observed in the region of pronounced inversion. This drop is governed by limitation of the space charge region by processes of tunneling generation via deep levels. The properties of the HgCdTe-insulator interfaces are studied.

  15. An Activity Theory Approach to Analyze Barriers to a Virtual Management Information Systems (MIS) Curriculum

    Science.gov (United States)

    Jaradat, Suhair; Qablan, Ahmad; Barham, Areej

    2011-01-01

    This paper explains how the activity theory is used as a framework to analyze the barriers to a virtual Management Information Stream (MIS) Curriculum in Jordanian schools, from both the sociocultural and pedagogical perspectives. Taking the activity system as a unit of analysis, this study documents the processes by which activities shape and are…

  16. Plasma Gelsolin Induced Glomerular Fibrosis via the TGF-β1/Smads Signal Transduction Pathway in IgA Nephropathy

    Directory of Open Access Journals (Sweden)

    Lei Zhang

    2017-02-01

    Full Text Available Glomerular fibrosis has been shown to be closely related to the progression and prognosis of IgA nephropathy (IgAN. However, mechanism underlying IgAN glomerular fibrosis remains unclear. Recently, our study showed that plasma gelsolin (pGSN was decreased in the serum of an IgAN mouse model and that pGSN deposition was found in the glomeruli. Another cytokine, TGF-β1, which is closely related to glomerular fibrosis, was also found to be highly expressed in the glomeruli. In the present study, we report that pGSN induces glomerular fibrosis through the TGF-β1/Smads signal transduction pathway. This is supported by the following findings: human mesangial cells (HMCs show remarkable morphological changes and proliferation in response to co-stimulation with pGSN and polymeric IgA1 (pIgA1 from IgAN patients compared to other controls. Moreover, ELISA assays showed that more TGF-β1 secretion was found in HMCs supernatants in the co-stimulation group. Further experiments showed increased TGF-β1, Smad3, p-Smad2/3, Smad4, and collagen 1 and decreased Smad7 expression in the co-stimulation group. Our present study implied that the synergistic effect of pGSN and pIgA induced glomerular fibrosis via the TGF-β1/Smads signal transduction pathway. This might be a potential mechanism for the glomerular fibrosis observed in IgAN patients.

  17. Plasma Gelsolin Induced Glomerular Fibrosis via the TGF-β1/Smads Signal Transduction Pathway in IgA Nephropathy

    Science.gov (United States)

    Zhang, Lei; Han, Changsong; Ye, Fei; He, Yan; Jin, Yinji; Wang, Tianzhen; Wu, Yiqi; Jiang, Yang; Zhang, Fengmin; Jin, Xiaoming

    2017-01-01

    Glomerular fibrosis has been shown to be closely related to the progression and prognosis of IgA nephropathy (IgAN). However, mechanism underlying IgAN glomerular fibrosis remains unclear. Recently, our study showed that plasma gelsolin (pGSN) was decreased in the serum of an IgAN mouse model and that pGSN deposition was found in the glomeruli. Another cytokine, TGF-β1, which is closely related to glomerular fibrosis, was also found to be highly expressed in the glomeruli. In the present study, we report that pGSN induces glomerular fibrosis through the TGF-β1/Smads signal transduction pathway. This is supported by the following findings: human mesangial cells (HMCs) show remarkable morphological changes and proliferation in response to co-stimulation with pGSN and polymeric IgA1 (pIgA1) from IgAN patients compared to other controls. Moreover, ELISA assays showed that more TGF-β1 secretion was found in HMCs supernatants in the co-stimulation group. Further experiments showed increased TGF-β1, Smad3, p-Smad2/3, Smad4, and collagen 1 and decreased Smad7 expression in the co-stimulation group. Our present study implied that the synergistic effect of pGSN and pIgA induced glomerular fibrosis via the TGF-β1/Smads signal transduction pathway. This might be a potential mechanism for the glomerular fibrosis observed in IgAN patients. PMID:28208683

  18. Patients with IgA nephropathy exhibit high systemic PDGF-DD levels.

    Science.gov (United States)

    Boor, Peter; Eitner, Frank; Cohen, Clemens D; Lindenmeyer, Maja T; Mertens, Peter R; Ostendorf, Tammo; Floege, Jürgen

    2009-09-01

    Platelet-derived growth factor (PDGF) is a central mediator of mesangioproliferative glomerulonephritis (GN). In experimental mesangioproliferative GN, PDGF-DD serum levels, unlike PDGF-BB, increased up to 1000-fold. We assessed disease activity in 72 patients with GN, established a novel PDGF-D ELISA and then determined their PDGF-DD levels. In parallel, we studied renal PDGF-DD mRNA expression by RT-PCR. PDGF-DD serum levels in patients with IgA nephropathy (IgAN) were significantly higher (1.67 +/- 0.45 ng/ml) and in patients with lupus nephritis significantly lower (0.66 +/- 0.86 ng/ml) compared to healthy controls (1.17 +/- 0.46 ng/ml), while patients with focal segmental glomerulosclerosis, membranous GN and ANCA-positive vasculitis did not differ from controls. The subgroup of IgAN patients with elevated PDGF-DD levels (27% of samples) did not differ in their clinical features from those with normal PDGF-DD levels. In IgAN patients with repetitive PDGF-DD determinations, most exhibited only minor fluctuations of serum levels over time. Intrarenal PDGF-DD mRNA expression did not differ between controls and patients, suggesting an extrarenal source of the elevated PDGF-DD in IgAN. Serum PDGF-DD levels were specifically elevated in patients with IgAN, in particular in those with early disease, i.e. preserved renal function. Our data support the rationale for anti-PDGF-DD therapy in mesangioproliferative GN.

  19. Impact of the -675 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene on childhood IgA nephropathy.

    Science.gov (United States)

    Han, Su-Ryun; Kim, Cheon-Jong; Lee, Byung-Cheol

    2012-04-01

    Plasminogen activator inhibitor-1 (PAI-1) is an important regulator of the fibrinolytic pathway and extracellular matrix (ECM) turnover. The -675 4G/5G polymorphism in the PAI-1 promoter is associated with altered PAI-1 transcription, suggesting that this polymorphism may be a candidate risk factor for diseases characterized by ECM accumulation, such as immunoglobulin A nephropathy (IgAN) and mesangial proliferative glomerulonephritis (MesPGN). We genotyped childhood patients with biopsy-confirmed IgAN (n=111) and MesPGN (n=47), and healthy control subjects (n=230) for the -675 4G/5G PAI-1 polymorphism by polymerase chain reaction-restriction fragment length polymorphism methods. The distribution of the 4G/4G (27.9%), 4G/5G (45.1%) and 5G/5G (27.0%) genotypes in IgAN patients was significantly different from the healthy controls (32.2, 54.3 and 13.5%, respectively) (p=0.0092). There was no significant difference in the genotype distributions of the 4G/5G polymorphism between MesPGN patients and the healthy controls. Regarding the impact of the polymorphism on IgAN, the 4G/4G genotype was markedly increased in patients with proteinuria (≥1,000 mg/day) and/or hypertension when compared to patients without proteinuria and hypertension (OR=5.23, 95% CI 1.34-20.38, P=0.0183). These findings indicate that the PAI-1 gene polymorphism may affect the susceptibility of childhood IgAN.

  20. New bound on MIS and MIN-CDS for a unit ball graph

    Directory of Open Access Journals (Sweden)

    D.A. Mojdeh

    2017-09-01

    Full Text Available The size of the maximum independent set (MIS in a graph G is called the independence number. The size of the minimum connected dominating set (MIN-CDS in G is called the connected domination number. The aim of this paper is to determine two better upper bounds of the independence number; dependent on the connected domination number for a unit ball graph. Further, we improve the upper bound to obtain the best bound with respect to the upper bounds obtained thus far.

  1. Electrical characterizations of MIS structures based on variable-gap n(p)-HgCdTe grown by MBE on Si(0 1 3) substrates

    Science.gov (United States)

    Voitsekhovskii, A. V.; Nesmelov, S. N.; Dzyadukh, S. M.; Varavin, V. S.; Dvoretskii, S. A.; Mikhailov, N. N.; Yakushev, M. V.; Sidorov, G. Yu.

    2017-12-01

    Metal-insulator-semiconductor (MIS) structures based on n(p)-Hg1-xCdxTe (x = 0.22-0.40) with near-surface variable-gap layers were grown by the molecular-beam epitaxy (MBE) technique on the Si (0 1 3) substrates. Electrical properties of MIS structures were investigated experimentally at various temperatures (9-77 K) and directions of voltage sweep. The ;narrow swing; technique was used to determine the spectra of fast surface states with the exception of hysteresis effects. It is established that the density of fast surface states at the MCT/Al2O3 interface at a minimum does not exceed 3 × 1010 eV-1 × cm-2. For MIS structures based on n-MCT/Si(0 1 3), the differential resistance of the space-charge region in strong inversion mode in the temperature range 50-90 K is limited by the Shockley-Read-Hall generation in the space-charge region.

  2. Edgar Savisaar: valitsus ei taju, mis linnas ta valitseb / Edgar Savisaar ; interv. Hille Tänavsuu

    Index Scriptorium Estoniae

    Savisaar, Edgar, 1950-

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke 15. nov. lk. 9. Tallinna linnapea vastab küsimustele, mis puudutavad Keskerakonna ainuvõimu Tallinnas, valimislubaduste täitmist, linnaelanike rahulolu, Keskerakonna toetust, pronksiöö sündmuste mõju Eesti majandusele, riigi ja linnavalitsuse suhteid, pealinna seadust, hüvede saamist linnavalitsuselt, tulevaste valimiste tulemusi. Lisa: Tallinna võim

  3. 32 CFR 22.325 - Historically Black colleges and universities (HBCUs) and other minority institutions (MIs).

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Historically Black colleges and universities (HBCUs) and other minority institutions (MIs). 22.325 Section 22.325 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-AWARD AND ADMINISTRATION Competition § 22.325...

  4. Silicon MIS diodes with Cr2O3 nanofilm: Optical, morphological/structural and electronic transport properties

    International Nuclear Information System (INIS)

    Erdogan, Ibrahim Y.; Guellue, O.

    2010-01-01

    In this work we report the optical, morphological and structural characterization and diode application of Cr 2 O 3 nanofilms grown on p-Si substrates by spin coating and annealing process. X-ray diffraction (XRD), non-contact mode atomic force microscopy (NC-AFM), ultraviolet-visible (UV-vis) spectroscopy and photoluminescence (PL) spectroscopy were used for characterization of nanofilms. For Cr 2 O 3 nanofilms, the average particle size determined from XRD and NC-AFM measurements was approximately 70 nm. Structure analyses of nanofilms demonstrate that the single phase Cr 2 O 3 on silicon substrate is of high a crystalline structure with a dominant in hexagonal (1 1 0) orientation. The morphologic analysis of the films indicates that the films formed from hexagonal nanoparticles are with low roughness and uniform. UV-vis absorption measurements indicate that the band gap of the Cr 2 O 3 film is 3.08 eV. The PL measurement shows that the Cr 2 O 3 nanofilm has a strong and narrow ultraviolet emission, which facilitates potential applications in future photoelectric nanodevices. Au/Cr 2 O 3 /p-Si metal/interlayer/semiconductor (MIS) diodes were fabricated for investigation of the electronic properties such as current-voltage and capacitance-voltage. Ideality factor and barrier height for Au//Cr 2 O 3 /p-Si diode were calculated as 2.15 eV and 0.74 eV, respectively. Also, interfacial state properties of the MIS diode were determined. The interface-state density of the MIS diode was found to vary from 2.90 x 10 13 eV -1 cm -2 to 8.45 x 10 12 eV -1 cm -2 .

  5. Growth of InGaAs/GaAsP multiple quantum well solar cells on mis-orientated GaAs substrates

    Energy Technology Data Exchange (ETDEWEB)

    Sodabanlu, Hassanet, E-mail: sodabanlu@hotaka.t.u-tokyo.ac.jp; Wang, Yunpeng; Watanabe, Kentaroh [Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904 (Japan); Sugiyama, Masakazu [Department of Electrical Engineering and Information System, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656 (Japan); Institute of Engineering Innovation, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656 (Japan); Nakano, Yoshiaki [Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904 (Japan); Department of Electrical Engineering and Information System, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656 (Japan)

    2014-06-21

    The effects of growth temperature on the properties of InGaAs/GaAsP multiple quantum well (MQW) solar cells on various mis-orientated GaAs substrates were studied using metalorganic vapor phase epitaxy. Thickness modulation effect caused by mismatch strain of InGaAs/GaAsP could be suppressed by low growth temperature. Consequently, abrupt MQWs with strong light absorption could be deposited on mis-oriented substrates. However, degradation in crystal quality and impurity incorporation are the main drawbacks with low temperature growth because they tend to strongly degraded carrier transport and collection efficiency. MQW solar cells grown at optimized temperature showed the better conversion efficiency. The further investigation should focus on improvement of crystal quality and background impurities.

  6. The complementarity of luminescence dating methods illustrated on the Mousterian sequence of the Roc de Marsal: A series of reindeer-dominated, Quina Mousterian layers dated to MIS 3

    DEFF Research Database (Denmark)

    Guerin, Guillaume; Frouin, Marine; Tuquoi, Joséphine

    2017-01-01

    that place mixed faunal assemblages in the initial MIS 4; however, while the Quina ages overlap with several other Quina assemblages from the region, they place the reindeer dominated fauna well after the peak cold of MIS 4 and suggest a more extended and complex period of contemporaneous lithic techno...

  7. Diagnostic and correction of chronic-biological mis-balances of population at radiation injuries in regions with increased radiation

    International Nuclear Information System (INIS)

    Goncharova, T.G.; Vasil'eva, G.S.

    2003-01-01

    It was shown the possibility of bio-indication of population irradiation and its rehabilitation by estimation of chronic biological mis-balances and correction realization. Investigation were accomplished on people contingent living at the former Semipalatinsk test site

  8. Andrew Smith: peame leidma tee majanduskasvuni, mis põhineb säästmisel, investeeringutel ja ekspordil / Andrew Smith

    Index Scriptorium Estoniae

    Smith, Andrew

    2010-01-01

    KPMG (UK) peaökonomist Andrew Smith vastab küsimustele, mis puudutavad majanduskriisi tekkimist, olukorra paranemist, majandusolukorda Suurbritannias, erinevusi Euroopa ja muude maailma piirkondade vahel, sarnasusi Eesti ja Suurbritannia majandusolukorra vahel ning prognoose edaspidiste arengute osas

  9. Isosorbide 5 mononitrate administration increases nitric oxide blood levels and reduces proteinuria in IgA glomerulonephritis patients with abnormal urinary endothelin/cyclic GMP ratio.

    Science.gov (United States)

    Roccatello, D; Mengozzi, G; Ferro, M; Cesano, G; Polloni, R; Mosso, R; Bonetti, G; Inconis, T; Paradisi, L; Sena, L M

    1995-09-01

    An endothelin urinary hyperexcretion, which is not counterbalanced by an adequate increase in cGMP biosynthesis, was previously detected in some patients with IgA Nephropathy (IgAN). Since this imbalance might potentiate local ET1-mediated hemodynamics effects, 9 IgAN patients with an increased (> or = 0.1) urinary ET1/cGMP ratio (group 1) and 5 IgAN patients with comparable renal function and reduced ET1/cGMP ratio (group 2) were given standard doses of isosorbide 5 mononitrate (as a nitric oxide source). Blood nitric oxide (NO) levels, as detected by electron paramagnetic resonance, significantly increased after isosorbide administration (p effective renal plasma flow (p counterbalancing effects of nitric oxide on endothelin-mediated mesangial contraction.

  10. Effects of {gamma}-ray irradiation on the C-V and G/{omega}-V characteristics of Al/SiO{sub 2}/p-Si (MIS) structures

    Energy Technology Data Exchange (ETDEWEB)

    Doekme, Ilbilge [Science Education Department, Faculty of Education, Ahi Evran University, Kirsehir (Turkey)], E-mail: ilbilgedokme@gazi.edu.tr; Durmus, Perihan; Altindal, Semsettin [Physics Department, Faculty of Arts and Sciences, Gazi University, 06500 Teknikokullar, Ankara (Turkey)

    2008-03-15

    The effect of the {sup 60}C{sub o} ({gamma}-ray) exposure on the electrical characteristics of Al/SiO{sub 2}/p-Si (MIS) structures has been investigated using capacitance-voltage (C-V) and conductance-voltage (G/{omega}-V) measurements. The MIS structures were stressed with a bias of 0 V during {sup 60}C{sub o}{gamma}-sources irradiation with the total dose range from 0 to 25 kGy. The C-V and G/{omega}-V characteristics were measured at 500 kHz and room temperature before and after {sup 60}C{sub o}{gamma}-ray irradiation. The results indicated that {gamma}-irradiation caused an increase in the barrier height {phi}{sub B}, interface states N{sub ss} and depletion layer width W{sub D} obtained from reverse bias C-V measurements. The series resistance R{sub s} profile for various radiation doses was obtained from forward and reverse bias C-V and G/{omega}-V measurements. Both C-V and G/{omega}-V characteristics indicate that the total dose radiation hardness of MIS structures may be limited by the decisive properties of the SiO{sub 2}/Si interface to radiation-induced damage. After {gamma}-irradiation, the decrease in capacitance of MIS structure results in the increase in the semiconductor depletion width.

  11. Andmekaitsemäärus - mis see on ja mida tähele panna? / Maarja Heinsoo, Märten Padu

    Index Scriptorium Estoniae

    Heinsoo, Maarja

    2016-01-01

    2016. aasta kevadel vastu võetud Euroopa Liidu isikuandmete kaitse üldmäärusest (General Data Protection Regulation), mis toob kaasa viimase kahekümne aasta suurima muutuse isikuandmete kaitse valdkonna reguleerimises. Rakendub alates 2018. aasta kevadest

  12. Fine-grained quartz OSL dating chronology of loess sequence from southern Tajikistan: Implications for climate change in arid central Asia during MIS 2

    Science.gov (United States)

    Wang, Leibin; Jia, Jia; Li, Guoqiang; Li, Zaijun; Wang, Xin; Chen, Fahu

    2018-04-01

    The desert and semi-desert region of arid central Asia is one of the most important areas of middle-latitude dust emission and deposition in the Northern Hemisphere. Marine isotope stage 2 (MIS 2) was the latest and one of the most representative intervals of dust emission from the region, and it is especially important for research into processes of dust transportation and deposition. Here, we report the results of an optically stimulated luminescence study of the Hoalin section in southern Tajikistan, which was deposited during MIS 2. The fine-grained quartz single aliquot regeneration (SAR) approach was used and its reliability was verified by internal checks. In addition, grain-size analyses, calculated dust accumulation rates (DARs) and mass accumulation rates (MARs) were used to reconstruct the pattern of climate change during MIS 2. The mean DAR for southern Tajikistan during MIS 2 was 0.43 m/ka, and the corresponding average MAR was 673 g/cm2/a for a non-river-terrace site, which is higher than the average MARs estimated for the central and southern Chinese Loess Plateau (CLP). In contrast to previous suggestions, the high dust DARs and MARs during the LGM indicate a 'cold-dry' climatic pattern, rather than a 'cold-humid' pattern. Our results also confirm that the patterns of high dust emission and deposition during the LGM in the mid-latitude arid zone of Asia were synchronous.

  13. Thin-barrier enhancement-mode AlGaN/GaN MIS-HEMT using ALD Al2O3 as gate insulator

    International Nuclear Information System (INIS)

    Wang Zheli; Zhou Jianjun; Kong Yuechan; Kong Cen; Dong Xun; Yang Yang; Chen Tangsheng

    2015-01-01

    A high-performance enhancement-mode (E-mode) gallium nitride (GaN)-based metal–insulator–semiconductor high electron mobility transistor (MIS-HEMT) that employs a 5-nm-thick aluminum gallium nitride (Al 0.3 Ga 0.7 N) as a barrier layer and relies on silicon nitride (SiN) passivation to control the 2DEG density is presented. Unlike the SiN passivation, aluminum oxide (Al 2 O 3 ) by atomic layer deposition (ALD) on AlGaN surface would not increase the 2DEG density in the heterointerface. ALD Al 2 O 3 was used as gate insulator after the depletion by etching of the SiN in the gate region. The E-mode MIS-HEMT with gate length (L G ) of 1 μm showed a maximum drain current density (I DS ) of 657 mA/mm, a maximum extrinsic transconductance (g m ) of 187 mS/mm and a threshold voltage (V th ) of 1 V. Comparing with the corresponding E-mode HEMT, the device performances had been greatly improved due to the insertion of Al 2 O 3 gate insulator. This provided an excellent way to realize E-mode AlGaN/GaN MIS-HEMTs with both high V th and I DS . (paper)

  14. Watertightness in anti-flotation slabs: MIS-RJ case

    Directory of Open Access Journals (Sweden)

    C. Britez

    Full Text Available It is common in coastal cities as Rio de Janeiro, that buildings located close to the shoreline have their basements below water table level. In most cases, the engineering solution for these buildings is to design a massive anti-flotation slab to satisfy, principally, the issues related to structural dimensioning and calculation hypothesis. On the other hand, the execution of this solution imply in significant construction problems related to reinforced concrete watertightness and durability. This paper presents a case study about challenges and solutions devised to execute an anti-flotation, 1m thick, 1200m³ reinforced concrete slab for the new Museu de Imagem e Som (MIS - Sound and Image Museum, located at 50m from the seashore, at Copacabana in Rio de Janeiro, RJ. The results show that concrete proportions, concreting plan and pouring method adopted were decisive in obtaining a watertight structure, avoiding thus the employment of traditional waterproofing alternatives.

  15. The Inchworm and the Nightingale: On the (Mis)use of Data in Music Teacher Evaluation

    Science.gov (United States)

    Robinson, Mitchell

    2015-01-01

    The music education profession is faced with two serious problems regarding the (mis)use of data in music teacher evaluation. The first has to do with the quality and kinds of data that music teachers have been forced to use; the second is concerned with how these data are being used in the music teacher evaluation process. The evidence I will use…

  16. An Empirical Examination of the Composition of Vocational Interest in Business Colleges: MIS vs. Other Majors

    Science.gov (United States)

    Downey, James

    2011-01-01

    Given the diminishing number of Management Information Systems (MIS) majors, an understanding of the factors which influence student choice of major is crucial. It has been noted in many previous studies that interest in a major and career significantly influences the student's choice of college major; indeed, in most studies, it is the strongest…

  17. Ambulatory blood pressure and tubulointerstitial injury in patients with IgA nephropathy.

    Science.gov (United States)

    Haruhara, Kotaro; Tsuboi, Nobuo; Koike, Kentaro; Kanzaki, Go; Okabayashi, Yusuke; Miyazaki, Yoichi; Kawamura, Tetsuya; Ogura, Makoto; Yokoo, Takashi

    2015-12-01

    Few studies have been conducted to assess the ambulatory blood pressure (ABP) in IgA nephropathy (IgAN) patients. This study aimed to determine the relationships between ABP and renal histopathological findings assessed using the Oxford classification (OC) and the Japanese classification (JC), which have recently established histopathological criteria for IgAN. This cross-sectional study included biopsy-diagnosed IgAN patients, in whom both a renal biopsy and ABP measurement were performed. The histopathological findings were assessed using the OC and the JC and were analyzed in relation to the ABP. A total of 111 IgAN patients were included. The score of interstitial fibrosis and tubular atrophy (T score) using the OC was a significantly associated factor with both the daytime and nighttime ABP values. In contrast, the other histopathological scores, including mesangial hypercellularity, endocapillary hypercellularity and segmental glomerulosclerosis, did not show significant associations with the ABP. The histological grade (H-grade) using the JC, which was based on the sum of injured glomeruli, was associated with the daytime ABP, but not with the nighttime ABP. The associations between the T score using the OC (%) and the daytime and nighttime ABP values were independent of age, gender, renal function, proteinuria and the use of antihypertensive medications, whereas the H-grade using the JC (%) did not show significant associations after adjusting for these clinical parameters. These results suggest that the T score using the OC is the most relevant renal histopathological parameter associated with abnormalities of circadian blood pressure in IgAN patients.

  18. Treatment of IgA nephropathy.

    Science.gov (United States)

    Barratt, J; Feehally, J

    2006-06-01

    IgA nephropathy (IgAN) is an important cause of progressive kidney disease with 25-30% of patients developing end-stage renal disease within 20 years of diagnosis. There is still no treatment to modify mesangial IgA deposition and available treatments are those extrapolated from the management of other patterns of chronic glomerulonephritis. There remains no consensus on the use of immunosuppressive agents for treatment of progressive IgAN and this is compounded by the relative lack in IgAN of randomized controlled trials relevant to current clinical practice. Patients with recurrent macroscopic hematuria or isolated microscopic hematuria and proteinuria renal biopsy should be managed as for minimal change nephropathy. There is no evidence to support the use of corticosteroids for nephrotic IgAN outside this group of patients. Patients presenting with acute renal failure require evaluation to distinguish acute tubular necrosis, which requires supportive therapy only, from crescentic IgAN, for which treatment with cyclophosphamide and corticosteroids in a regimen similar to that for renal small vessel vasculitis is indicated in the absence of significant chronic histologic injury. Patients at greatest risk of progressive renal impairment are those with hypertension, proteinuria >1 g/24 h, and reduced glomerular filtration rate at diagnosis. All such patients should be treated to a blood pressure of 125/75 mm Hg with dual blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibition and angiotensin receptor blockade. At present, there is insufficient evidence for the additional use of immunosuppressive agents, antiplatelet agents, or anticoagulants.

  19. A Combined MIS/DS Course Uses Lecture Capture Technology to "Level the Playing Field" in Student Numeracy

    Science.gov (United States)

    Popovich, Karen

    2012-01-01

    This paper describes the process taken to develop a quantitative-based and Excel™-driven course that combines "BOTH" Management Information Systems (MIS) and Decision Science (DS) modeling outcomes and lays the foundation for upper level quantitative courses such as operations management, finance and strategic management. In addition,…

  20. The (Mis)understanding of Scientific Uncertainty? How Experts View Policy-Makers, the Media and Publics

    OpenAIRE

    Landstrom, Catharina; Hauxwell-Baldwin, Richard; Lorenzoni, Irene; Rogers-Hayden, Tee

    2015-01-01

    Frequent claims that publics ‘misunderstand’ science ignore the contested definition of scientific uncertainty itself. Scientific uncertainty means different things in the natural sciences, social sciences and the humanities, while public controversies show that these interpretations of scientific uncertainty have different implications for policy and decision-making. This prompts analysis of the ways that experts view scientific uncertainty and how they characterise the (mis)understandings o...

  1. Temperature dependence and effects of series resistance on current and admittance measurements of Al/SnO2/p-Si MIS diode

    International Nuclear Information System (INIS)

    Altindal, S.; Tekeli, Z.; Karadeniz, S.; Sahingoez, R.

    2002-01-01

    Temperature dependency and the series resistance effect on I-V, C-V and G-V characteristics of Al/SnO 2 /p-Si MIS diode were investigated in the temperature range 150-350 K. The current-voltage (I-V) analysis in this temperature range gives the saturation current (10''-''9 - 10''-''5 A), the ideality factor (6-1.8), the barrier height Φ B (I-V) (0.3-0.65 eV) the density of interface states D it (8x10''1''3 - 1x10''1''3 eV''-''1cm''-''2) and the series resistance R s (500-100 Ω). The decreases with increasing temperature of density of interface states is the result of molecular restructuring and reordering at the metal-semiconductor interface. The value of series resistance 520 Ω was calculated from the admittance measurement at room temperature and enough high frequency (500 khz) when the diode is biased in strong accumulation region. The admittance frequency (C-V and G-V) measurement confirmed that the measured capacitance (C m ) and conductance (G m ) varies with applied voltage and frequency due to the presence of density of interface states in the MIS diode, interfacial insulator layer and enough high series resistance. Similar results have been observed on MIS type Schottky diodes

  2. A rhinocerotid-dominated megafauna at the MIS6-5 transition: The late Middle Pleistocene Coc Muoi assemblage, Lang Son province, Vietnam

    Science.gov (United States)

    Bacon, Anne-Marie; Antoine, Pierre-Olivier; Huong, Nguyen Thi Mai; Westaway, Kira; Tuan, Nguyen Anh; Duringer, Philippe; Zhao, Jian-xin; Ponche, Jean-Luc; Dung, Sam Canh; Nghia, Truong Huu; Minh, Tran Thi; Son, Pham Thanh; Boyon, Marc; Thuy, Nguyen Thi Kim; Blin, Amandine; Demeter, Fabrice

    2018-04-01

    Little is known about the ecosystems in the north of the Indochinese peninsula at the Middle-Late Pleistocene transition. In this paper, we analyzed the new fauna from Coc Muoi cave, Lang Son province, northeast Vietnam. In comparison with other well-documented faunas from the region, that of Coc Muoi is distinguished by the predominance of rhinoceroses among diverse large-bodied herbivores. The results of the OSL and pIR-IRSL dating of the cave sediments and U-series dating of flowstones indicate a potential age range of 148-117 ka for the fauna (MIS6-5). The analysis of age-at-death distributions of rhinoceroses, wild cattle, sambar deer, and wild pig, does not show any apparent selectivity of age classes. We also focused our study on rhinoceroses, tapirs, and wild cattle by analyzing the prevalence of hypoplastic defects on deciduous and permanent teeth, in an attempt to assess the health status of the taxa during their first years of growth. The health status of large-bodied herbivores (kouprey and rhinoceros) reveals the importance of stressors (biotic and abiotic) in the rainforest environment during a period of marked climatic transition (MIS6-5) in comparison with other MIS5-4 well-documented faunas from the region.

  3. Radiographic and clinical outcomes following MIS-TLIF in patients with adult lumbar degenerative scoliosis.

    Science.gov (United States)

    Zhao, Yongfei; Liang, Yan; Mao, Keya

    2018-04-19

    Patients suffering from adult lumbar degenerative scoliosis (ALDS) are commonly complicated with advanced age, osteoporosis, cardiopulmonary insufficiency, and some other medical comorbidity. Therefore, the traditional open surgery can lead to high rate of postoperative complications. The purposes of this study were to introduce our experiences and explore the efficacy and feasibility of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of patients with ALDS. From January 2008 to January 2014, a retrospective study of 22 patients with ALDS treated with MIS-TLIF was followed up at least 2 years. All patients suffered from one-level lumbar stenosis, and the nerve root block was performed to make sure the exact level. The clinical and radiographic outcomes were evaluated preoperatively and at the time of 2-year follow-up. The mean visual analog scale (VAS) back pain scores decreased from 6.2 ± 1.8 preoperatively to 2.2 ± 0.7 at 2-year follow-up (P < 0.05), and the mean VAS leg pain scores decreased from 8.2 ± 0.7 preoperatively to 1.4 ± 1.4 at 2-year follow-up (P < 0.05). The Oswestry Disability Index score improved from 62.4 ± 16.1% preoperatively to 24.2 ± 9.3% at 2-year follow-up (P < 0.05). The average lumbar curve was 20.7° ± 7.0° preoperatively and 12.7° ± 7.1° at 2-year follow-up (P < 0.05). The lumbar lordosis changed from - 39.5° ± 13.6° to - 43.6° ± 10.6° at 2-year follow-up (P < 0.05). Solid fusion was achieved in all patients. The technique of MIS-TLIF can be used to treat the patients with ALDS whose symptom is mainly from one-level lumbar stenosis, achieving favorable clinical outcomes and good fusion, with less blood loss and complications.

  4. Using Mobility to Enhance the Routing Process in the MIS System

    Directory of Open Access Journals (Sweden)

    Elkoutbi Mohammed

    2009-10-01

    Full Text Available In this paper, we introduce the original Mobile Intelligent System (MIS in embedded FPGA architecture. This node will allow the construction of autonomous mobile network units which can move in unknowns, inaccessible or hostile environnement for human being, in order to collect data by various sensors and transmits them by routing to a unit of distant process. In the sake of improving the performance of routing unit, we propose a measure of mobility. Each node measure its own mobility in the network, based on the change of the links state in his neighboring. This measure of mobility has no unit, and it is calculated by quantification in regular time intervals.

  5. Suppression in the electrical hysteresis by using CaF2 dielectric layer for p-GaN MIS capacitors

    Science.gov (United States)

    Sang, Liwen; Ren, Bing; Liao, Meiyong; Koide, Yasuo; Sumiya, Masatomo

    2018-04-01

    The capacitance-voltage (C-V) hysteresis in the bidirectional measurements of the p-GaN metal-insulator-semiconductor (MIS) capacitor is suppressed by using a CaF2 dielectric layer and a post annealing treatment. The density of trapped charge states at the CaF2/p-GaN interface is dramatically reduced from 1.3 × 1013 cm2 to 1.1 × 1011/cm2 compared to that of the Al2O3/p-GaN interface with a large C-V hysteresis. It is observed that the disordered oxidized interfacial layer can be avoided by using the CaF2 dielectric. The downward band bending of p-GaN is decreased from 1.51 to 0.85 eV as a result of the low-density oxides-related trap states. Our work indicates that the CaF2 can be used as a promising dielectric layer for the p-GaN MIS structures.

  6. CURRENT ISSUES IN OUTSOURCING: MIS, AIS AND BEYOND

    Directory of Open Access Journals (Sweden)

    AIDA SY

    2012-01-01

    Full Text Available En años recientes, el outsourcing se ha venido convirtiendo en una tendencia tanto en empresas de Europa y los Estados Unidos. Ni siquiera, trabajadores muy calificados se salvan de este asalto.La vanidad de los intelectuales y los profesionales que ejecutan tanto sistemas de información contable(AIS, como sistemas de información de gestión (MIS es su creencia de que están exentos de estosprocesos de outsourcing. Algunos creen que disfrutan de una vida de ensueño, que la demanda de sus servicios está asegurada. Se consuelan pensando que el aumento de su dominiotécnico les ofrece una defensa suficiente contra los ataques provenientes del mercado laboral y de productos.Una interpretación desde los estudios críticos indicará que esta posición es un acto dearrogancia, siendo esto el eje de la discusión de este documento. Tal actitud de los profesionales contables es una reminiscencia del Rey Canuto esperando que la marea retroceda.

  7. The effect of mis-specification on mean and selection between the Weibull and lognormal models

    Science.gov (United States)

    Jia, Xiang; Nadarajah, Saralees; Guo, Bo

    2018-02-01

    The lognormal and Weibull models are commonly used to analyse data. Although selection procedures have been extensively studied, it is possible that the lognormal model could be selected when the true model is Weibull or vice versa. As the mean is important in applications, we focus on the effect of mis-specification on mean. The effect on lognormal mean is first considered if the lognormal sample is wrongly fitted by a Weibull model. The maximum likelihood estimate (MLE) and quasi-MLE (QMLE) of lognormal mean are obtained based on lognormal and Weibull models. Then, the impact is evaluated by computing ratio of biases and ratio of mean squared errors (MSEs) between MLE and QMLE. For completeness, the theoretical results are demonstrated by simulation studies. Next, the effect of the reverse mis-specification on Weibull mean is discussed. It is found that the ratio of biases and the ratio of MSEs are independent of the location and scale parameters of the lognormal and Weibull models. The influence could be ignored if some special conditions hold. Finally, a model selection method is proposed by comparing ratios concerning biases and MSEs. We also present a published data to illustrate the study in this paper.

  8. A high-elevation, multi-proxy biotic and environmental record of MIS 6-4 from the Ziegler Reservoir fossil site, Snowmass Village, Colorado, USA

    Science.gov (United States)

    Miller, Ian M.; Pigati, Jeffrey S.; Anderson, R. Scott; Johnson, Kirk R.; Mahan, Shannon; Ager, Thomas A.; Baker, Richard G.; Blaauw, Maarten; Bright, Jordon; Brown, Peter M.; Bryant, Bruce; Calamari, Zachary T.; Carrara, Paul E.; Michael D., Cherney; Demboski, John R.; Elias, Scott A.; Fisher, Daniel C.; Gray, Harrison J.; Haskett, Danielle R.; Honke, Jeffrey S.; Jackson, Stephen T.; Jiménez-Moreno, Gonzalo; Kline, Douglas; Leonard, Eric M.; Lifton, Nathaniel A.; Lucking, Carol; McDonald, H. Gregory; Miller, Dane M.; Muhs, Daniel R.; Nash, Stephen E.; Newton, Cody; Paces, James B.; Petrie, Lesley; Plummer, Mitchell A.; Porinchu, David F.; Rountrey, Adam N.; Scott, Eric; Sertich, Joseph J. W.; Sharpe, Saxon E.; Skipp, Gary L.; Strickland, Laura E.; Stucky, Richard K.; Thompson, Robert S.; Wilson, Jim

    2014-01-01

    In North America, terrestrial records of biodiversity and climate change that span Marine Oxygen Isotope Stage (MIS) 5 are rare. Where found, they provide insight into how the coupling of the ocean–atmosphere system is manifested in biotic and environmental records and how the biosphere responds to climate change. In 2010–2011, construction at Ziegler Reservoir near Snowmass Village, Colorado (USA) revealed a nearly continuous, lacustrine/wetland sedimentary sequence that preserved evidence of past plant communities between ~ 140 and 55 ka, including all of MIS 5. At an elevation of 2705 m, the Ziegler Reservoir fossil site also contained thousands of well-preserved bones of late Pleistocene megafauna, including mastodons, mammoths, ground sloths, horses, camels, deer, bison, black bear, coyotes, and bighorn sheep. In addition, the site contained more than 26,000 bones from at least 30 species of small animals including salamanders, otters, muskrats, minks, rabbits, beavers, frogs, lizards, snakes, fish, and birds. The combination of macro- and micro-vertebrates, invertebrates, terrestrial and aquatic plant macrofossils, a detailed pollen record, and a robust, directly dated stratigraphic framework shows that high-elevation ecosystems in the Rocky Mountains of Colorado are climatically sensitive and varied dramatically throughout MIS 5.

  9. Interface Si donor control to improve dynamic performance of AlGaN/GaN MIS-HEMTs

    Science.gov (United States)

    Song, Liang; Fu, Kai; Zhang, Zhili; Sun, Shichuang; Li, Weiyi; Yu, Guohao; Hao, Ronghui; Fan, Yaming; Shi, Wenhua; Cai, Yong; Zhang, Baoshun

    2017-12-01

    In this letter, we have studied the performance of AlGaN/GaN metal-insulator-semiconductor high electron mobility transistors (MIS-HEMTs) with different interface Si donor incorporation which is tuned during the deposition process of LPCVD-SiNx which is adopted as gate dielectric and passivation layer. Current collapse of the MIS-HEMTs without field plate is suppressed more effectively by increasing the SiH2Cl2/NH3 flow ratio and the normalized dynamic on-resistance (RON) is reduced two orders magnitude after off-state VDS stress of 600 V for 10 ms. Through interface characterization, we have found that the interface deep-level traps distribution with high Si donor incorporation by increasing the SiH2Cl2/NH3 flow ratio is lowered. It's indicated that the Si donors are most likely to fill and screen the deep-level traps at the interface resulting in the suppression of slow trapping process and the virtual gate effect. Although the Si donor incorporation brings about the increase of gate leakage current (IGS), no clear degradation of breakdown voltage can be seen by choosing appropriate SiH2Cl2/NH3 flow ratio.

  10. Effect of low-dose valsartan on proteinuria in normotensive immunoglobulin A nephropathy with minimal proteinuria: a randomized trial.

    Science.gov (United States)

    Jo, Young-Il; Na, Ha-Young; Moon, Ju-Young; Han, Sang-Woong; Yang, Dong-Ho; Lee, Sang-Ho; Park, Hyeong-Cheon; Choi, Hoon-Young; Lim, So-Dug; Kie, Jeong-Hae; Lee, Yong-Kyu; Shin, Sug-Kyun

    2016-03-01

    Immunoglobulin A nephropathy (IgAN) is a generally progressive disease, even in patients with favorable prognostic features. In this study, we aimed to investigate the antiproteinuric effect and tolerability of low-dose valsartan (an angiotensin II receptor blocker) therapy in normotensive IgAN patients with minimal proteinuria of less than 0.5 to 1.0 g/day. Normotensive IgAN patients, who had persistent proteinuria with a spot urine protein-to-creatinine ratio of 0.3 to 1.0 mg/mg creatinine, were recruited from five hospitals and randomly assigned to either 40 mg of valsartan as the low-dose group or 80 mg of valsartan as the regular-dose group. Clinical and laboratory data were collected at baseline, and at 4, 8, 12, and 24 weeks after valsartan therapy. Forty-three patients (low-dose group, n = 23; regular-dose group, n = 20) were enrolled in the study. Proteinuria decreased significantly not only in the regular-dose group but also in the low-dose group. The change in urine protein-to-creatinine ratio at week 24 was -41.3% ± 26.1% (p valsartan can significantly reduce proteinuria without causing any intolerability in normotensive IgAN patients with minimal proteinuria.

  11. IgA nephropathy in systemic lupus erythematosus patients: case report and literature review

    Directory of Open Access Journals (Sweden)

    Leonardo Sales da Silva

    2016-06-01

    Full Text Available Abstract Systemic erythematosus lupus (SLE is a multisystemic autoimmune disease which has nephritis as one of the most striking manifestations. Although it can coexist with other autoimmune diseases, and determine the predisposition to various infectious complications, SLE is rarely described in association with non‐lupus nephropathies etiologies. We report the rare association of SLE and primary IgA nephropathy (IgAN, the most frequent primary glomerulopathy in the world population. The patient was diagnosed with SLE due to the occurrence of malar rash, alopecia, pleural effusion, proteinuria, ANA 1: 1,280, nuclear fine speckled pattern, and anticardiolipin IgM and 280 U/mL. Renal biopsy revealed mesangial hypercellularity with isolated IgA deposits, consistent with primary IgAN. It was treated with antimalarial drug, prednisone and inhibitor of angiotensin converting enzyme, showing good progress. Since they are relatively common diseases, the coexistence of SLE and IgAN may in fact be an uncommon finding for unknown reasons or an underdiagnosed condition. This report focus on the importance of the distinction between the activity of renal disease in SLE and non‐SLE nephropathy, especially IgAN, a definition that has important implications on renal prognosis and therapeutic regimens to be adopted in the short and long term.

  12. High-frequency climate linkages between the North Atlantic and the Mediterranean during marine oxygen isotope stage 100 (MIS100)

    NARCIS (Netherlands)

    Becker, Julia; Lourens, L.J.; Raymo, M.E.

    2006-01-01

    High-resolution records of Mediterranean and North Atlantic deep-sea sediments indicate that rapid changes in hydrology and climate occurred during marine oxygen isotope stage 100 (MIS100) (at ~2.52 Ma), which exhibits characteristics similar to late Pleistocene Dansgaard-Oeschger, Bond cycles and

  13. Fabrication and electrical characteristics for MIS diode by utilizing TiO2 ceramics

    International Nuclear Information System (INIS)

    Bae, S.H.

    1981-01-01

    Metal insulator semiconductor diodes were made by utilizing TiO 2 ceramics. Tunnel field emission is here proposed as a model for rectification in TiO 2 diode. Measurements of junction depth show very satisfactory agreement with value obtained from the Richardson plot, thus serving as additional supporting evidence of field emission in TiO 2 ceramic. The measured junction area exceeds by a factor of 10 6 the value expected by assuming field emission. The Richardson plot shows a deviation from the emission theory at low voltage, which is probably due to leakage currents which are present in MIS rutile diode. (author)

  14. Clinical validation of immunoglobulin A nephropathy diagnosis in Swedish biopsy registers

    Directory of Open Access Journals (Sweden)

    Jarrick S

    2017-01-01

    Full Text Available Simon Jarrick,1,2 Sigrid Lundberg,3,4 Adina Welander,5,6 C Michael Fored,6 Jonas F Ludvigsson2,7,8 1Department of Pediatrics, Faculty of Health and Medicine, Örebro University, 2Department of Pediatrics, Örebro University Hospital, Örebro, 3Department of Nephrology, Karolinska University Hospital, 4Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 5Boston Consulting Group, 6Clinical Epidemiology Unit, Department of Medicine, 7Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 8Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK Aims: The aims of this study were to validate the diagnosis of IgA nephropathy (IgAN in Swedish biopsy registers against patient charts and to describe the clinical characteristics of patients with a biopsy indicating IgAN. Methods: This is a population-based cohort study. Out of 4,069 individuals with a renal biopsy consistent with IgAN (biopsies performed in 1974–2011, this study reviewed patient charts of a random subset of 127 individuals. Clinical and biopsy characteristics at the time of biopsy were evaluated, and positive predictive values (PPV were calculated with 95% confidence intervals (CI. Results: Out of 127 individuals with a renal biopsy consistent with IgAN, 121 had a likely or confirmed clinical diagnosis of IgAN, primary or secondary to Henoch–Schönlein purpura, yielding a PPV of 95% (95% CI =92%–99%. The median age at biopsy was 39 years (range: 4–79 years; seven patients (6% were <16 years. The male to female ratio was 2.8:1. The most common causes for consultation were macroscopic hematuria (n=37; 29%, screening (n=33; 26%, and purpura (n=14, 11%. In patients with available data, the median creatinine level was 104 µmol/L (range 26–986 µmol/L, n=110 and glomerular filtration rate 75 mL/min/1.73m² (range 5–173 mL/min/1.73m², n=114. Hypertension was

  15. "The Brick People" by Alejandro Morales, novel and documentary: A story of intercultural (mis)communication

    OpenAIRE

    Lanslots, Inge; Van Hecke, An

    2015-01-01

    "The Brick People" by Alejandro Morales, novel and documentary: A story of intercultural (mis)communication The focus of this study is an analysis of the novel The Brick People published by the Chicano author Alejandro Morales in 1988 and its homonymous documentary film from 2012. Both narrations are based on a true story, namely the lives of Mexican immigrants at the beginning of the twentieth century, who worked as employees in Simons Brickyard in Los Angeles, California. Simons Brickya...

  16. Uncertainty of block estimates introduced by mis-allocation of point samples: on the example of spatial indoor Radon data

    Energy Technology Data Exchange (ETDEWEB)

    Bossew, P. [European Commission (Ecuador), Joint Research Centre (JRC), Institute for Environment and Sustainability (IES), TP441, Via Fermi 1, I-21020 Ispra (Italy)], E-mail: peter.bossew@jrc.it

    2009-03-15

    The European indoor Radon map which is currently under production is based on gridded data supplied by the contributing countries. Each grid node represents the arithmetic mean (among other statistics) of the individual measurements within 10 x 10 km{sup 2}, called cells, pixels or blocks, which are aligned to a common metric coordinate system. During work the question emerged, if uncertainty in the geo-referencing of individual data might affect the aggregated 'block' statistics to an extent that the statistics have an unpredictably high additional uncertainty, which makes them unusable. In this note we try to quantify the effect, based on simulations. The overall result is that the relevant statistics should not be affected too badly in most cases, in particular if the rate of mis-allocations, and the mean uncertainty of coordinates are not too high, so that also cell statistics which are to some degree distorted by mis-allocated data, can still be used for the purpose of the European Radon map.

  17. A high-elevation, multi-proxy biotic and environmental record of MIS 6–4 from the Ziegler Reservoir fossil site, Snowmass Village, Colorado, USA

    Energy Technology Data Exchange (ETDEWEB)

    Ian M. Miller; Mitchell A. Plummer; Various Others

    2014-10-01

    In North America, terrestrial records of biodiversity and climate change that span Marine Oxygen Isotope Stage (MIS) 5 are rare. Where found, they provide insight into how the coupling of the ocean–atmosphere system is manifested in biotic and environmental records and how the biosphere responds to climate change. In 2010–2011, construction at Ziegler Reservoir near Snowmass Village, Colorado (USA) revealed a nearly continuous, lacustrine/wetland sedimentary sequence that preserved evidence of past plant communities between ~140 and 55 ka, including all of MIS 5. At an elevation of 2705 m, the Ziegler Reservoir fossil site also contained thousands of well-preserved bones of late Pleistocene megafauna, including mastodons, mammoths, ground sloths, horses, camels, deer, bison, black bear, coyotes, and bighorn sheep. In addition, the site contained more than 26,000 bones from at least 30 species of small animals including salamanders, otters, muskrats, minks, rabbits, beavers, frogs, lizards, snakes, fish, and birds. The combination of macro- and micro-vertebrates, invertebrates, terrestrial and aquatic plant macrofossils, a detailed pollen record, and a robust, directly dated stratigraphic framework shows that high-elevation ecosystems in the Rocky Mountains of Colorado are climatically sensitive and varied dramatically throughout MIS 5

  18. Contrasting Responses of the Humboldt Current Ecosystem between the Holocene and MIS5e Interglacials Revealed from Multiple Sediment Records

    Science.gov (United States)

    Salvatteci, R.; Schneider, R. R.; Blanz, T.; Martinez, P.; Crosta, X.

    2016-12-01

    The Humboldt Current Ecosystem (HCE) off Peru yields about 10% of the global fish catch, producing more fish per unit area than any other region in the world. The high productivity is maintained by the upwelling of cold, nutrient-rich water from the oxygen minimum zone (OMZ), driven by strong trade winds. However, the potential impacts of climate change on upwelling dynamics and oceanographic conditions in the near future are uncertain, threatening local and global economies. Here, we unravel the response of the HCE to contrasting climatic conditions during the last two interglacials (i.e. Holocene and MIS5e) providing an independent insight about the relation between climatic factors and upwelling and productivity dynamics. For this purpose, we used multiple cores to reconstruct past changes in OMZ and upwelling intensity, productivity and fish biomass variability. Chronologies for the Holocene were obtained by multiple 14C ages and laminae correlations among cores, while for the MIS5e they were mainly done by correlation of prominent features in several proxies with other published records. We used a multiproxy approach including alkenones to reconstruct sea surface temperatures, δ15N as a proxy for water column denitrification, redox sensitive metals as proxies for sediment redox conditions, and diatom and fish debris assemblages to reconstruct ecological changes. The results show a very different response of the HCE to climate conditions during the last 2 interglacials, likely driven by changes in Tropical Pacific dynamics. During the Holocene we find that 1) the Late Holocene exhibits higher multi-centennial scale variability compared to the Early Holocene, 2) increased upwelling and a weak OMZ during the mid-Holocene, and 3) long term increase in productivity (diatoms and fishes) from the Early to the Late Holocene. During the MIS5e we find an 1) intense OMZ, 2) strong water column stratification, 3) high siliceous biomass, and 4) low fish biomass compared

  19. Silicon MIS diodes with Cr{sub 2}O{sub 3} nanofilm: Optical, morphological/structural and electronic transport properties

    Energy Technology Data Exchange (ETDEWEB)

    Erdogan, Ibrahim Y. [Bingoel University, Faculty of Sciences and Arts, Department of Chemistry, 12000- Bingoel (Turkey); Guellue, O., E-mail: omergullu@gmail.com [Batman University, Faculty of Sciences and Arts, Department of Physics, 72060- Batman (Turkey)

    2010-04-15

    In this work we report the optical, morphological and structural characterization and diode application of Cr{sub 2}O{sub 3} nanofilms grown on p-Si substrates by spin coating and annealing process. X-ray diffraction (XRD), non-contact mode atomic force microscopy (NC-AFM), ultraviolet-visible (UV-vis) spectroscopy and photoluminescence (PL) spectroscopy were used for characterization of nanofilms. For Cr{sub 2}O{sub 3} nanofilms, the average particle size determined from XRD and NC-AFM measurements was approximately 70 nm. Structure analyses of nanofilms demonstrate that the single phase Cr{sub 2}O{sub 3} on silicon substrate is of high a crystalline structure with a dominant in hexagonal (1 1 0) orientation. The morphologic analysis of the films indicates that the films formed from hexagonal nanoparticles are with low roughness and uniform. UV-vis absorption measurements indicate that the band gap of the Cr{sub 2}O{sub 3} film is 3.08 eV. The PL measurement shows that the Cr{sub 2}O{sub 3} nanofilm has a strong and narrow ultraviolet emission, which facilitates potential applications in future photoelectric nanodevices. Au/Cr{sub 2}O{sub 3}/p-Si metal/interlayer/semiconductor (MIS) diodes were fabricated for investigation of the electronic properties such as current-voltage and capacitance-voltage. Ideality factor and barrier height for Au//Cr{sub 2}O{sub 3}/p-Si diode were calculated as 2.15 eV and 0.74 eV, respectively. Also, interfacial state properties of the MIS diode were determined. The interface-state density of the MIS diode was found to vary from 2.90 x 10{sup 13} eV{sup -1} cm{sup -2} to 8.45 x 10{sup 12} eV{sup -1} cm{sup -2}.

  20. Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients.

    Science.gov (United States)

    Yin, Shanye; Lopez-Gonzalez, Rodrigo; Kunz, Ryan C; Gangopadhyay, Jaya; Borufka, Carl; Gygi, Steven P; Gao, Fen-Biao; Reed, Robin

    2017-06-13

    Hexanucleotide repeat expansion in the C9ORF72 gene results in production of dipeptide repeat (DPR) proteins that may disrupt pre-mRNA splicing in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients. At present, the mechanisms underlying this mis-splicing are not understood. Here, we show that addition of proline-arginine (PR) and glycine-arginine (GR) toxic DPR peptides to nuclear extracts blocks spliceosome assembly and splicing, but not other types of RNA processing. Proteomic and biochemical analyses identified the U2 small nuclear ribonucleoprotein particle (snRNP) as a major interactor of PR and GR peptides. In addition, U2 snRNP, but not other splicing factors, mislocalizes from the nucleus to the cytoplasm both in C9ORF72 patient induced pluripotent stem cell (iPSC)-derived motor neurons and in HeLa cells treated with the toxic peptides. Bioinformatic studies support a specific role for U2-snRNP-dependent mis-splicing in C9ORF72 patient brains. Together, our data indicate that DPR-mediated dysfunction of U2 snRNP could account for as much as ∼44% of the mis-spliced cassette exons in C9ORF72 patient brains. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  1. Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients

    Directory of Open Access Journals (Sweden)

    Shanye Yin

    2017-06-01

    Full Text Available Hexanucleotide repeat expansion in the C9ORF72 gene results in production of dipeptide repeat (DPR proteins that may disrupt pre-mRNA splicing in amyotrophic lateral sclerosis (ALS and frontotemporal dementia (FTD patients. At present, the mechanisms underlying this mis-splicing are not understood. Here, we show that addition of proline-arginine (PR and glycine-arginine (GR toxic DPR peptides to nuclear extracts blocks spliceosome assembly and splicing, but not other types of RNA processing. Proteomic and biochemical analyses identified the U2 small nuclear ribonucleoprotein particle (snRNP as a major interactor of PR and GR peptides. In addition, U2 snRNP, but not other splicing factors, mislocalizes from the nucleus to the cytoplasm both in C9ORF72 patient induced pluripotent stem cell (iPSC-derived motor neurons and in HeLa cells treated with the toxic peptides. Bioinformatic studies support a specific role for U2-snRNP-dependent mis-splicing in C9ORF72 patient brains. Together, our data indicate that DPR-mediated dysfunction of U2 snRNP could account for as much as ∼44% of the mis-spliced cassette exons in C9ORF72 patient brains.

  2. Photoelectrical measurements of the local value of the contact potential difference in the metal-insulator semiconductor (MIS) structures

    Energy Technology Data Exchange (ETDEWEB)

    Kudla, A.; Przewlocki, H.M.; Borowicz, L.; Brzezinska, D.; Rzodkiewicz, W

    2004-02-22

    In this work the local values of contact potential difference (CPD) and their distributions in the plane of the metal-insulator-semiconductor (MIS) structure's gate have been determined for the first time. This has been achieved by application of a focused beam of UV radiation from a laser source. The less than 20-{mu}m diameter of UV radiation beam allows determination of distributions of local CPD values in the plane of the gate. The CPD distribution is such that its values are highest far away from the gate edge regions, lower in the vicinity of gate edges and still lower in the vicinity of gate corners. In this paper the method and the optical setup used to determine local values of CPD are described and example measurement results are given. The CPD distributions obtained have been confirmed by a series of independent measurements by other methods. It is believed that the CPD distributions obtained (as well as distributions of local values of other parameters) are due to the mechanical stress distributions under the gate of a MIS system.

  3. Glomerular diseases: emerging tests and therapies for IgA nephropathy.

    Science.gov (United States)

    Canetta, Pietro A; Kiryluk, Krzysztof; Appel, Gerald B

    2014-03-01

    The last decade has seen major progress in understanding the pathogenesis as well as the prognosis and treatment of patients with IgA nephropathy (IgAN). Although the diagnostic criterion of a kidney biopsy demonstrating dominant or codominant IgA deposition remains unchanged, much more is known about the genetic and environmental factors predisposing to disease development and progression. These advances have led to the identification of novel diagnostic and prognostic markers. Among the most promising clinically are genetic profiling, quantification of galactose-deficient IgA1 levels, and measurement of anti-IgA1 immunoglobulins. While targeted treatment for IgAN remains elusive, there is mounting evidence for therapeutic interventions that alter the disease course. The appropriate validation and integration of these discoveries into clinical care represent a major challenge, but one that holds tremendous promise for refining prognostication, guiding therapy, and improving the lives of patients with IgAN.

  4. Insulin-like growth factor binding protein-1 levels are increased in patients with IgA nephropathy

    International Nuclear Information System (INIS)

    Tokunaga, Koki; Uto, Hirofumi; Takami, Yoichiro; Mera, Kumiko; Nishida, Chika; Yoshimine, Yozo; Fukumoto, Mayumi; Oku, Manei; Sogabe, Atsushi; Nosaki, Tsuyoshi; Moriuchi, Akihiro; Oketani, Makoto; Ido, Akio; Tsubouchi, Hirohito

    2010-01-01

    Research highlights: → IGFBP-1 mRNA over express in kidneys obtained from mice model of IgA nephropathy. → Serum IGFBP-1 levels are high in patients with IgA nephropathy. → Serum IGFBP-1 levels correlate with renal function and the severity of renal injury. -- Abstract: The mechanisms underlying the pathogenesis of immunoglobulin A (IgA) nephropathy (IgAN) are not well understood. In this study, we examined gene expression profiles in kidneys obtained from mice with high serum IgA levels (HIGA mice), which exhibit features of human IgAN. Female inbred HIGA, established from the ddY line, were used in these experiments. Serum IgA levels, renal IgA deposition, mesangial proliferation, and glomerulosclerosis were increased in 32-week-old HIGA mice in comparison to ddY animals. By microarray analysis, five genes were observed to be increased by more than 2.5-fold in 32-week-old HIGA in comparison to 16-week-old HIGA; these same five genes were decreased more than 2.5-fold in 32-week-old ddY in comparison to 16-week-old ddY mice. Of these five genes, insulin-like growth factor (IGF) binding protein (IGFBP)-1 exhibited differential expression between these mouse lines, as confirmed by quantitative RT-PCR. In addition, serum IGFBP-1 levels were significantly higher in patients with IgAN than in healthy controls. In patients with IgAN, these levels correlated with measures of renal function, such as estimated glomerular filtration rate (eGFR), but not with sex, age, serum IgA, C3 levels, or IGF-1 levels. Pathologically, serum IGFBP-1 levels were significantly associated with the severity of renal injury, as assessed by mesangial cell proliferation and interstitial fibrosis. These results suggest that increased IGFBP-1 levels are associated with the severity of renal pathology in patients with IgAN.

  5. Insulin-like growth factor binding protein-1 levels are increased in patients with IgA nephropathy

    Energy Technology Data Exchange (ETDEWEB)

    Tokunaga, Koki [Department of Digestive and Life-Style Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520 (Japan); Uto, Hirofumi, E-mail: hirouto@m2.kufm.kagoshima-u.ac.jp [Department of Digestive and Life-Style Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520 (Japan); Takami, Yoichiro; Mera, Kumiko; Nishida, Chika; Yoshimine, Yozo; Fukumoto, Mayumi; Oku, Manei; Sogabe, Atsushi; Nosaki, Tsuyoshi; Moriuchi, Akihiro; Oketani, Makoto; Ido, Akio; Tsubouchi, Hirohito [Department of Digestive and Life-Style Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520 (Japan)

    2010-08-20

    Research highlights: {yields} IGFBP-1 mRNA over express in kidneys obtained from mice model of IgA nephropathy. {yields} Serum IGFBP-1 levels are high in patients with IgA nephropathy. {yields} Serum IGFBP-1 levels correlate with renal function and the severity of renal injury. -- Abstract: The mechanisms underlying the pathogenesis of immunoglobulin A (IgA) nephropathy (IgAN) are not well understood. In this study, we examined gene expression profiles in kidneys obtained from mice with high serum IgA levels (HIGA mice), which exhibit features of human IgAN. Female inbred HIGA, established from the ddY line, were used in these experiments. Serum IgA levels, renal IgA deposition, mesangial proliferation, and glomerulosclerosis were increased in 32-week-old HIGA mice in comparison to ddY animals. By microarray analysis, five genes were observed to be increased by more than 2.5-fold in 32-week-old HIGA in comparison to 16-week-old HIGA; these same five genes were decreased more than 2.5-fold in 32-week-old ddY in comparison to 16-week-old ddY mice. Of these five genes, insulin-like growth factor (IGF) binding protein (IGFBP)-1 exhibited differential expression between these mouse lines, as confirmed by quantitative RT-PCR. In addition, serum IGFBP-1 levels were significantly higher in patients with IgAN than in healthy controls. In patients with IgAN, these levels correlated with measures of renal function, such as estimated glomerular filtration rate (eGFR), but not with sex, age, serum IgA, C3 levels, or IGF-1 levels. Pathologically, serum IGFBP-1 levels were significantly associated with the severity of renal injury, as assessed by mesangial cell proliferation and interstitial fibrosis. These results suggest that increased IGFBP-1 levels are associated with the severity of renal pathology in patients with IgAN.

  6. Comparative study on nitridation and oxidation plasma interface treatment for AlGaN/GaN MIS-HEMTs with AlN gate dielectric

    Science.gov (United States)

    Zhu, Jie-Jie; Ma, Xiao-Hua; Hou, Bin; Chen, Li-Xiang; Zhu, Qing; Hao, Yue

    2017-02-01

    This paper demonstrated the comparative study on interface engineering of AlN/AlGaN/GaN metal-insulator-semiconductor high-electron-mobility transistors (MIS-HEMTs) by using plasma interface pre-treatment in various ambient gases. The 15 nm AlN gate dielectric grown by plasma-enhanced atomic layer deposition significantly suppressed the gate leakage current by about two orders of magnitude and increased the peak field-effect mobility by more than 50%. NH3/N2 nitridation plasma treatment (NPT) was used to remove the 3 nm poor-quality interfacial oxide layer and N2O/N2 oxidation plasma treatment (OPT) to improve the quality of interfacial layer, both resulting in improved dielectric/barrier interface quality, positive threshold voltage (V th) shift larger than 0.9 V, and negligible dispersion. In comparison, however, NPT led to further decrease in interface charges by 3.38 × 1012 cm-2 and an extra positive V th shift of 1.3 V. Analysis with fat field-effect transistors showed that NPT resulted in better sub-threshold characteristics and transconductance linearity for MIS-HEMTs compared with OPT. The comparative study suggested that direct removing the poor interfacial oxide layer by nitridation plasma was superior to improving the quality of interfacial layer by oxidation plasma for the interface engineering of GaN-based MIS-HEMTs.

  7. Interface Si donor control to improve dynamic performance of AlGaN/GaN MIS-HEMTs

    Directory of Open Access Journals (Sweden)

    Liang Song

    2017-12-01

    Full Text Available In this letter, we have studied the performance of AlGaN/GaN metal-insulator-semiconductor high electron mobility transistors (MIS-HEMTs with different interface Si donor incorporation which is tuned during the deposition process of LPCVD-SiNx which is adopted as gate dielectric and passivation layer. Current collapse of the MIS-HEMTs without field plate is suppressed more effectively by increasing the SiH2Cl2/NH3 flow ratio and the normalized dynamic on-resistance (RON is reduced two orders magnitude after off-state VDS stress of 600 V for 10 ms. Through interface characterization, we have found that the interface deep-level traps distribution with high Si donor incorporation by increasing the SiH2Cl2/NH3 flow ratio is lowered. It’s indicated that the Si donors are most likely to fill and screen the deep-level traps at the interface resulting in the suppression of slow trapping process and the virtual gate effect. Although the Si donor incorporation brings about the increase of gate leakage current (IGS, no clear degradation of breakdown voltage can be seen by choosing appropriate SiH2Cl2/NH3 flow ratio.

  8. Assessment of the reliability and consistency of the "malnutrition inflammation score" (MIS) in Mexican adults with chronic kidney disease for diagnosis of protein-energy wasting syndrome (PEW).

    Science.gov (United States)

    González-Ortiz, Ailema Janeth; Arce-Santander, Celene Viridiana; Vega-Vega, Olynka; Correa-Rotter, Ricardo; Espinosa-Cuevas, María de Los Angeles

    2014-10-04

    The protein-energy wasting syndrome (PEW) is a condition of malnutrition, inflammation, anorexia and wasting of body reserves resulting from inflammatory and non-inflammatory conditions in patients with chronic kidney disease (CKD).One way of assessing PEW, extensively described in the literature, is using the Malnutrition Inflammation Score (MIS). To assess the reliability and consistency of MIS for diagnosis of PEW in Mexican adults with CKD on hemodialysis (HD). Study of diagnostic tests. A sample of 45 adults with CKD on HD were analyzed during the period June-July 2014.The instrument was applied on 2 occasions; the test-retest reliability was calculated using the Intraclass Correlation Coefficient (ICC); the internal consistency of the questionnaire was analyzed using Cronbach's αcoefficient. A weighted Kappa test was used to estimate the validity of the instrument; the result was subsequently compared with the Bilbrey nutritional index (BNI). The reliability of the questionnaires, evaluated in the patient sample, was ICC=0.829.The agreement between MIS observations was considered adequate, k= 0.585 (p <0.001); when comparing it with BNI, a value of k = 0.114 was obtained (p <0.001).In order to estimate the tendency, a correlation test was performed. The r² correlation coefficient was 0.488 (P <0.001). MIS has adequate reliability and validity for diagnosing PEW in the population with chronic kidney disease on HD. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  9. Techno-Cultural Characterization of the MIS 5 (c. 105 - 90 Ka Lithic Industries at Blombos Cave, Southern Cape, South Africa.

    Directory of Open Access Journals (Sweden)

    Katja Douze

    Full Text Available Blombos Cave is well known as an important site for understanding the evolution of symbolically mediated behaviours among Homo sapiens during the Middle Stone Age, and during the Still Bay in particular. The lower part of the archaeological sequence (M3 phase contains 12 layers dating to MIS 5 with ages ranging from 105 to 90 ka ago (MIS 5c to 5b that provide new perspectives on the technological behaviour of these early humans. The new data obtained from our extensive technological analysis of the lithic material enriches our currently limited knowledge of this time period in the Cape region. By comparing our results with previously described lithic assemblages from sites south of the Orange River, we draw new insights on the extent of the techno-cultural ties between these sites and the M3 phase at Blombos Cave and highlight the importance of this phase within the Middle Stone Age cultural stratigraphy.

  10. High capacitance density MIS capacitor using Si nanowires by MACE and ALD alumina dielectric

    Energy Technology Data Exchange (ETDEWEB)

    Leontis, I.; Nassiopoulou, A. G., E-mail: A.Nassiopoulou@inn.demokritos.gr [INN, NCSR Demokritos, Patriarchou Grigoriou and Neapoleos, Aghia Paraskevi, 153 10 Athens (Greece); Botzakaki, M. A.; Georga, S. N. [Department of Physics, University of Patras, 26 504 Rion (Greece)

    2016-06-28

    High capacitance density three-dimensional (3D) metal-insulator-semiconductor (MIS) capacitors using Si nanowires (SiNWs) by metal-assisted chemical etching and atomic-layer-deposited alumina dielectric film were fabricated and electrically characterized. A chemical treatment was used to remove structural defects from the nanowire surface, in order to reduce the density of interface traps at the Al{sub 2}O{sub 3}/SiNW interface. SiNWs with two different lengths, namely, 1.3 μm and 2.4 μm, were studied. A four-fold capacitance density increase compared to a planar reference capacitor was achieved with the 1.3 μm SiNWs. In the case of the 2.4 μm SiNWs this increase was ×7, reaching a value of 4.1 μF/cm{sup 2}. Capacitance-voltage (C-V) measurements revealed that, following a two-cycle chemical treatment, frequency dispersion at accumulation regime and flat-band voltage shift disappeared in the case of the 1.3 μm SiNWs, which is indicative of effective removal of structural defects at the SiNW surface. In the case of the 2.4 μm SiNWs, frequency dispersion at accumulation persisted even after the two-step chemical treatment. This is attributed to a porous Si layer at the SiNW tops, which is not effectively removed by the chemical treatment. The electrical losses of MIS capacitors in both cases of SiNW lengths were studied and will be discussed.

  11. High capacitance density MIS capacitor using Si nanowires by MACE and ALD alumina dielectric

    International Nuclear Information System (INIS)

    Leontis, I.; Nassiopoulou, A. G.; Botzakaki, M. A.; Georga, S. N.

    2016-01-01

    High capacitance density three-dimensional (3D) metal-insulator-semiconductor (MIS) capacitors using Si nanowires (SiNWs) by metal-assisted chemical etching and atomic-layer-deposited alumina dielectric film were fabricated and electrically characterized. A chemical treatment was used to remove structural defects from the nanowire surface, in order to reduce the density of interface traps at the Al_2O_3/SiNW interface. SiNWs with two different lengths, namely, 1.3 μm and 2.4 μm, were studied. A four-fold capacitance density increase compared to a planar reference capacitor was achieved with the 1.3 μm SiNWs. In the case of the 2.4 μm SiNWs this increase was ×7, reaching a value of 4.1 μF/cm"2. Capacitance-voltage (C-V) measurements revealed that, following a two-cycle chemical treatment, frequency dispersion at accumulation regime and flat-band voltage shift disappeared in the case of the 1.3 μm SiNWs, which is indicative of effective removal of structural defects at the SiNW surface. In the case of the 2.4 μm SiNWs, frequency dispersion at accumulation persisted even after the two-step chemical treatment. This is attributed to a porous Si layer at the SiNW tops, which is not effectively removed by the chemical treatment. The electrical losses of MIS capacitors in both cases of SiNW lengths were studied and will be discussed.

  12. CO-INTEGRATION DAN CONTAGION EFFECT ANTARA PASAR SAHAM SYARIAH DI INDONESIA, MALAYSIA, EROPA, DAN AMERIKA SAAT TERJADINYA KRISIS YUNANI

    Directory of Open Access Journals (Sweden)

    Tara Ninta Ikrima

    2015-06-01

    Full Text Available Penelitian ini bertujuan untuk menganalisis dampak krisis di Yunani terhadap pergerakan harga saham syariah di Indonesia, Malaysia, Amerika Serikat, dan Eropa. Selain itu, penelitian ini juga menganalisis co-integrasi dan efek penularan (contagion effect yang terjadi selama periode ini. Penelitian ini dilakukan karena ada perbedaan antara hasil penelitian tentang US Subprime Mortgage periode krisis tentang dampak pasar saham syariah. Penelitian ini menggunakan VAR (Vector Auto Regressive dan VECM (Vector Error Correction Model untuk menguji hipotesis dengan EViews 6 digunakan sebagai alat analisis statistik. Data yang digunakan dalam penelitian ini adalah indeks harga saham penutupan mingguan yang diambil dari perwakilan pasar saham syariah masing-masing negara, JII untuk Indonesia, DJIMY untuk Malaysia, DJIM US, dan MSCI untuk Eropa. Hasilnya menunjukkan bahwa Krisis Yunani tidak memiliki pengaruh terhadap pergerakan harga saham Islam di AS, Malaysia, Indonesia, dan Eropa. Namun ada co-integrasi dan penularan berpengaruh terhadap harga saham Islam di empat wilayah saat krisis Yunani itu terjadi. The objective of the study was to analyze the Greece’s crisis impacts toward the movement of Islamic stock prices in Indonesia, Malaysia, USA, and Europe. Moreover, this study also analyzed co-integration and contagion effect which occurred during the period. VAR (Vector Auto Regressive and VECM (Vector Error Correction Model with eviews 6 were used to test the hypothesis as the statistical analysis tools. The data of this study were the weekly closing stock price indices taken from the representatives of Islamic stock markets of each country; JII in Indonesia, DJIMY in Malaysia, DJIM in USA, and MSCI in Europe. The result showed that the Greece’s crisis did not give any influence toward the movement of Islamic stock prices in USA, Malaysia, Indonesia, and Europe. However; there were co-integration and contagion effect which influenced on Islamic

  13. The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients.

    Science.gov (United States)

    Kaihan, Ahmad Baseer; Yasuda, Yoshinari; Katsuno, Takayuki; Kato, Sawako; Imaizumi, Takahiro; Ozeki, Takaya; Hishida, Manabu; Nagata, Takanobu; Ando, Masahiko; Tsuboi, Naotake; Maruyama, Shoichi

    2017-12-01

    The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN). A retrospective cohort study including 86 adult IgAN patients was conducted. The Oxford Classification and the JHC were evaluated by 7 independent specialists. The JHC, MEST score in the Oxford Classification, and crescents were analyzed in association with renal outcome, defined as a 50% increase in serum creatinine. In multivariate analysis without the JHC, only the T score was significantly associated with renal outcome. While, a significant association was revealed only in the JHC on multivariate analysis with JHC. The JHC and T score in the Oxford Classification were associated with renal outcome among Japanese patients with IgAN. Superiority of the JHC as a predictive index should be validated with larger study population and cohort studies in different ethnicities.

  14. Marine Isotope Stage (MIS) M2 ( 3.3 Ma) in the southern hemisphere: constraining the climatic drivers of a short-term glaciation event during the Pliocene warm Period.

    Science.gov (United States)

    De Vleeschouwer, D.; Auer, G.; Bogus, K.; Groeneveld, J.; Henderiks, J.; Jatiningrum, R. S.; Christensen, B. A.

    2017-12-01

    Global climate was characterized by intriguing climate variability during the Late Pliocene (3.6 to 2.59 Ma): a brief (<100 kyr) but intense glaciation (MIS M2) interrupted the relatively warm climate state around 3.3 Ma. Until today, different hypotheses exist to explain why this glaciation event was so intense, and why the global climate system returned to warm Pliocene conditions relatively quickly. One of these proposed mechanisms is a reduced equator-to-pole heat transfer, in response to a tectonically reduced Indonesian Throughflow (ITF; De Schepper et al., 2014; Karas et al., 2011a, b). However, the scarcity of orbital-scale continuous climate archives in the outflow of the Indonesian Seaway hampers testing this hypothesis. To assess the supposed relationship between mid-Pliocene glaciations and latitudinal heat transport through the Indonesian Throughflow, we constructed a 3-kyr resolution planktonic δ18OG.sacculiferrecord for the 3.9 - 2.7 Ma interval from Site U1463 (18°59'S, 117°37'E; Northwestern Australian Shelf; IODP Expedition 356 "Indonesian Throughflow"). The U1463 oxygen isotope record concurs exceptionally well with the sea surface temperature (SST) record from Site 806 (0°19'N, 159°22'E) in the West Pacific Warm Pool (Wara et al., 2005), even during MIS M2. Hence, Site U1463 suggests an uninterrupted ITF signal during Pliocene glaciations. Surprisingly though, the U1463 δ18OG.sacculifer record exhibits a 0.5‰ offset with the nearby Site 763 record (20°35'S, 112°12'E) around MIS M2. This implies that Site 763, which lies a bit further offshore than U1463, fits better with Indian Ocean SST records (e.g. Site 214; Karas et al., 2009) across MIS M2. In conclusion, the U1463 data reveal that heat-transport through the Indonesian Throughflow did not shut down completely during MIS M2. However, its intensity decreased during MIS M2, causing Site 763 to temporarily reflect an Indian Ocean, rather than an ITF signal. References De Schepper, S

  15. Human choices and environmental constraints: deciphering the variability of large game procurement from Mousterian to Aurignacian times (MIS 5-3) in southwestern France

    Science.gov (United States)

    Discamps, Emmanuel; Jaubert, Jacques; Bachellerie, François

    2011-09-01

    The evolution in the selection of prey made by past humans, especially the Neandertals and the first anatomically modern humans, has been widely debated. Between Marine Isotope Stages (MIS) 5 and 3, the accuracy of absolute dating is still insufficient to precisely correlate paleoclimatic and archaeological data. It is often difficult, therefore, to estimate to what extent changes in species procurement are correlated with either climate fluctuations or deliberate cultural choices in terms of subsistence behavior. Here, the full development of archeostratigraphy and Bayesian statistical analysis of absolute dates allows the archeological and paleoclimatic chronologies to be compared. The variability in hunted fauna is investigated using multivariate statistical analysis of quantitative faunal lists of 148 assemblages from 39 archeological sequences from MIS 5 through MIS 3. Despite significant intra-technocomplex variability, it is possible to identify major shifts in the human diet during these stages. The integration of archeological data, paleoclimatic proxies and the ecological characteristics of the different species of prey shows that the shifts in large game hunting can be explained by an adaptation of the human groups to climatic fluctuations. However, even if Middle and Early Upper Paleolithic men adapted to changes in their environment and to contrasting landscapes, they ultimately belonged to the ecosystems of the past and were limited by environmental constraints.

  16. Temperature Dependences of the Product of the Differential Resistance by the Area in MIS-Structures Based on Cd x Hg1- x Te Grown by Molecularbeam Epitaxy on Alternative Si and GaAs Substrates

    Science.gov (United States)

    Voitsekhovskii, A. V.; Nesmelov, S. N.; Dzyadukh, S. M.; Varavin, V. S.; Vasil'ev, V. V.; Dvoretskii, S. A.; Mikhailov, N. N.; Yakushev, M. V.; Sidorov, G. Yu.

    2017-06-01

    In a temperature range of 9-200 K, temperature dependences of the differential resistance of space-charge region in the strong inversion mode are experimentally studied for MIS structures based on CdxHg1-xTe (x = 0.22-0.40) grown by molecular-beam epitaxy. The effect of various parameters of structures: the working layer composition, the type of a substrate, the type of insulator coating, and the presence of a near-surface graded-gap layer on the value of the product of differential resistance by the area is studied. It is shown that the values of the product RSCRA for MIS structures based on n-CdHgTe grown on a Si(013) substrate are smaller than those for structures based on the material grown on a GaAs(013) substrate. The values of the product RSCRA for MIS structures based on p-CdHgTe grown on a Si(013) substrate are comparable with the value of the analogous parameter for MIS structures based on p-CdHgTe grown on a GaAs(013) substrate.

  17. Modeling the evolution of the Laurentide Ice Sheet from MIS 3 to the Last Glacial Maximum: an approach using sea level modeling and ice flow dynamics

    Science.gov (United States)

    Weisenberg, J.; Pico, T.; Birch, L.; Mitrovica, J. X.

    2017-12-01

    The history of the Laurentide Ice Sheet since the Last Glacial Maximum ( 26 ka; LGM) is constrained by geological evidence of ice margin retreat in addition to relative sea-level (RSL) records in both the near and far field. Nonetheless, few observations exist constraining the ice sheet's extent across the glacial build-up phase preceding the LGM. Recent work correcting RSL records along the U.S. mid-Atlantic dated to mid-MIS 3 (50-35 ka) for glacial-isostatic adjustment (GIA) infer that the Laurentide Ice Sheet grew by more than three-fold in the 15 ky leading into the LGM. Here we test the plausibility of a late and extremely rapid glaciation by driving a high-resolution ice sheet model, based on a nonlinear diffusion equation for the ice thickness. We initialize this model at 44 ka with the mid-MIS 3 ice sheet configuration proposed by Pico et al. (2017), GIA-corrected basal topography, and mass balance representative of mid-MIS 3 conditions. These simulations predict rapid growth of the eastern Laurentide Ice Sheet, with rates consistent with achieving LGM ice volumes within 15 ky. We use these simulations to refine the initial ice configuration and present an improved and higher resolution model for North American ice cover during mid-MIS 3. In addition we show that assumptions of ice loads during the glacial phase, and the associated reconstructions of GIA-corrected basal topography, produce a bias that can underpredict ice growth rates in the late stages of the glaciation, which has important consequences for our understanding of the speed limit for ice growth on glacial timescales.

  18. Interface properties of MIS structures based on hetero-epitaxial graded-gap Hg1-xCdxTe with CdTe interlayer created in situ during MBE growth

    Science.gov (United States)

    Voitsekhovskii, Alexander V.; Nesmelov, Sergey N.; Dzyadukh, Stanislav M.; Varavin, Vasily S.; Dvoretsky, Sergey A.; Mikhailov, Nikolay N.; Yakushev, Maksim V.; Sidorov, Georgy Yu.

    2017-11-01

    Heterostructures based on n-Hg1-xCdxTe (x = 0.23-0.40) with near-surface graded-gap layers were grown by molecular beam epitaxy on Si (013) substrates. At 77 K, the admittance of the In/Al2O3/Hg1-xCdxTe metal-insulator-semiconductor (MIS) structures with grown in situ CdTe intermediate layer and without such a layer was investigated. It has been established that MIS structures of In/Al2O3/Hg1-xCdxTe with an interlayer of in situ grown CdTe are characterized by the electrical strength of the dielectric and the qualitative interface. The hysteresis of the capacitive characteristics is practically absent within a small range of variation in the bias voltage. The density of fast surface states at the minimum does not exceed 2.2 × 1010 eV-1 cm-2. MIS structures of In/Al2O3/Hg1-xCdxTe without an intermediate layer of CdTe have significantly higher densities of fast and slow surface states, as well as lower values of the differential resistance of the space-charge region in the regime of strong inversion.

  19. Retraduzir a obra para traduzir o rascunho: tradução da poética do rascunho em Mon coeur mis à nu, de Charles Baudelaire

    Directory of Open Access Journals (Sweden)

    Oliveira, Thiago Mattos de

    2015-10-01

    Full Text Available Similarly to Fernando Pessoa’s Livro do Desassossego, Mon coeur mis à nu presents itself as an unfinished work, constituted by disperse, provisional, sometimes incomplete notes. Some critics believe that such works were not meant to be oeuvres, but drafts, works in progress, unachieved-unachievable texts. Based on Didier’s (1973 notion of draft poetics, it is now possible to consider that incompleteness is inherent to these works; they constitute themselves in and through their incompleteness. Provisionality, hesitancy, unfinishedness are constitutive of this draft poetics. It is our aim to discuss and work out a way of translating Mon coeur mis à nu by building on its procedural and incomplete dimension, seeking to highlight the many ways of ordering and structuring the text, and paying attention to the materiality of the manuscript and its revision process. Therefore, I propose resorting to hypertext, a translational and editorial strategy that would allow a rhizomatic and multicursal reading of this material, enabling the reader to experience the haunting and the “monstrosity” of the moving textuality that appears in Mon coeur mis à nu.

  20. Plasma exchange in Immunoglobulin A nephropathy with thrombotic microangiopathy and acute cortical necrosis

    Directory of Open Access Journals (Sweden)

    P Doddi

    2016-01-01

    Full Text Available A 25-year-old female presented with decreased urine output, deranged renal function, thrombocytopenia, and hemolytic anemia. Kidney biopsy was consistent with thrombotic microangiopathy with acute cortical necrosis and Immunoglobulin A nephropathy (IgAN. Hemolytic anemia, thrombocytopenia and urine output improved after five sessions of plasma exchange. Renal function showed a delayed recovery and serum creatinine normalized by 3 months. This is first case of successful use of plasma exchange in hemolytic uremic syndrome with cortical necrosis associated with IgAN.

  1. Potential fluctuations due to randomly distributed charges at the semiconductor-insulator interface in MIS-structures

    International Nuclear Information System (INIS)

    Yanchev, I.

    2003-01-01

    A new expression for the Fourier transform of the binary correlation function of the random potential near the semiconductor-insulator interface is derived. The screening from the metal electrode in MIS-structure is taken into account introducing an effective insulator thickness. An essential advantage of this correlation function is the finite dispersion of the random potential to which it leads in distinction with the so far known correlation functions leading to a divergent dispersion. The dispersion, an important characteristic of the random potential distribution, determining the amplitude of the potential fluctuations is calculated

  2. Potential fluctuations due to randomly distributed charges at the semiconductor-insulator interface in MIS-structures

    CERN Document Server

    Yanchev, I

    2003-01-01

    A new expression for the Fourier transform of the binary correlation function of the random potential near the semiconductor-insulator interface is derived. The screening from the metal electrode in MIS-structure is taken into account introducing an effective insulator thickness. An essential advantage of this correlation function is the finite dispersion of the random potential to which it leads in distinction with the so far known correlation functions leading to a divergent dispersion. The dispersion, an important characteristic of the random potential distribution, determining the amplitude of the potential fluctuations is calculated.

  3. Potential fluctuations due to randomly distributed charges at the semiconductor-insulator interface in MIS-structures

    Energy Technology Data Exchange (ETDEWEB)

    Yanchev, I

    2003-07-01

    A new expression for the Fourier transform of the binary correlation function of the random potential near the semiconductor-insulator interface is derived. The screening from the metal electrode in MIS-structure is taken into account introducing an effective insulator thickness. An essential advantage of this correlation function is the finite dispersion of the random potential to which it leads in distinction with the so far known correlation functions leading to a divergent dispersion. The dispersion, an important characteristic of the random potential distribution, determining the amplitude of the potential fluctuations is calculated.

  4. Multiproxy record of the last interglacial (MIS 5e) off central and northern California, U.S.A., from Ocean Drilling Program sites 1018 and 1020

    Science.gov (United States)

    Poore, Richard Z.; Dowsett, H.J.; Barron, J.A.; Heusser, L.; Ravelo, A.C.; Mix, A.

    2000-01-01

    Environmental and climatic conditions during the last interglacial (about 125,000 years ago) along the Central and Northern California coastal region are interpreted from study of marine cores recovered by the Ocean Drilling Program at sites 1018 and 1020. Marine microfossil and pollen assemblages, oxygen isotopes in benthic foraminifers, physical properties, and calcium carbonate contents of cored sediments are proxies indicating strong links between the marine and terrestrial environments during marine isotope stage 5 (MIS 5). At the beginning of the last interglacial (MIS 5e), reduction in global ice volume, increase in surface temperature, and warming of air temperature along the Central and Northern California coast were synchronous within the resolution of our sampling record.

  5. Prognostic impact of serum bilirubin level on long-term renal survival in IgA nephropathy.

    Science.gov (United States)

    Tanaka, Shigeru; Ninomiya, Toshiharu; Masutani, Kosuke; Nagata, Masaharu; Tsuchimoto, Akihiro; Tsuruya, Kazuhiko; Kitazono, Takanari

    2015-12-01

    Serum bilirubin has been recognized as a novel endogenous antioxidant. The aim of our study was to evaluate the impact of serum bilirubin on kidney prognosis in IgA nephropathy (IgAN). We followed retrospectively 694 patients with IgAN diagnosed by renal biopsy between 1982 and 2010. The risk factors for developing end-stage renal disease (ESRD) were estimated using a Cox proportional hazard model. Predictive performance between models with or without serum bilirubin was evaluated by calculating the net reclassification improvement (NRI) and integrated discrimination improvement (IDI). Seventy-seven patients developed ESRD during the median 4.9 years of follow-up. Estimated glomerular filtration rate, proteinuria and histological severity were inversely related to bilirubin levels. In multivariate analysis, serum bilirubin was an independent risk factor for ESRD (hazard ratio for every 0.1 mg/dL decrease in serum bilirubin, 1.18; 95 % CI, 1.04-1.33). The incidence rate of ESRD decreased linearly with the increases in bilirubin levels (P for trend bilirubin was incorporated into a model with conventional ESRD risk factors, the NRI and IDI were 0.281 (P = 0.02) and 0.019 (P = 0.01), respectively. We demonstrated that lower bilirubin levels were significantly associated with higher risk of ESRD in IgAN. In addition, bilirubin provided incremental predictive value in the risk assessment for progression of IgAN beyond that provided by standard risk factors.

  6. Pre-transplant course and risk of kidney transplant failure in IgA nephropathy patients.

    Science.gov (United States)

    Bjørneklett, Rune; Vikse, Bjørn Egil; Smerud, Hilde Kloster; Bostad, Leif; Leivestad, Torbjørn; Hartmann, Anders; Iversen, Bjarne M

    2011-01-01

    There is lack of knowledge to what degree clinical/morphological presentation and course of IgA nephropathy (IgAN) prior to end-stage renal disease are risk factors for graft loss after kidney transplantation. Patients with IgAN between 1988 and 2006 (registered in the Norwegian Kidney Biopsy Registry) who later received a kidney transplant (registered in the Norwegian Renal Registry) were included. The cohort was followed up regarding death-censored graft loss throughout 2008. Graft survival with a rapid progressive (RP) vs. a slow progressive (SP) course of pre-Tx IgAN (annual GFR > or <30 mL/min/1.73 m(2) ) was studied. Among 106 included patients, there were 14 graft losses giving a graft loss rate of 1.9/100 patient years. Follow-up until the first kidney transplant was 6.9 ± 4.4 (range 0.1-19) yr. Patients with pre-Tx RP had a higher graft loss rate compared with SP patients (6.3 vs.1.3/100 patient years, p < 0.001). Graft loss rate with living-related donor (LRD) was similar to unrelated donor (UD) grafts. Most RP patients had received LRD grafts, and in SP patients, graft survival with LRD grafts was better than UD grafts (0.3 vs.2.1/100 patient years, p = 0.055). A rapid pre-transplant course is a strong risk factor for transplant failure in patients with IgAN. © 2011 John Wiley & Sons A/S.

  7. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells.

    Directory of Open Access Journals (Sweden)

    William T Silkworth

    Full Text Available Many cancer cells display a CIN (Chromosome Instability phenotype, by which they exhibit high rates of chromosome loss or gain at each cell cycle. Over the years, a number of different mechanisms, including mitotic spindle multipolarity, cytokinesis failure, and merotelic kinetochore orientation, have been proposed as causes of CIN. However, a comprehensive theory of how CIN is perpetuated is still lacking. We used CIN colorectal cancer cells as a model system to investigate the possible cellular mechanism(s underlying CIN. We found that CIN cells frequently assembled multipolar spindles in early mitosis. However, multipolar anaphase cells were very rare, and live-cell experiments showed that almost all CIN cells divided in a bipolar fashion. Moreover, fixed-cell analysis showed high frequencies of merotelically attached lagging chromosomes in bipolar anaphase CIN cells, and higher frequencies of merotelic attachments in multipolar vs. bipolar prometaphases. Finally, we found that multipolar CIN prometaphases typically possessed gamma-tubulin at all spindle poles, and that a significant fraction of bipolar metaphase/early anaphase CIN cells possessed more than one centrosome at a single spindle pole. Taken together, our data suggest a model by which merotelic kinetochore attachments can easily be established in multipolar prometaphases. Most of these multipolar prometaphase cells would then bi-polarize before anaphase onset, and the residual merotelic attachments would produce chromosome mis-segregation due to anaphase lagging chromosomes. We propose this spindle pole coalescence mechanism as a major contributor to chromosome instability in cancer cells.

  8. New Spectral Method for Halo Particle Definition in Intense Mis-matched Beams

    Energy Technology Data Exchange (ETDEWEB)

    Dorf, Mikhail A.; Davidson, Ronald C.; Startsev, Edward A.

    2011-04-27

    An advanced spectral analysis of a mis-matched charged particle beam propagating through a periodic focusing transport lattice is utilized in particle-in-cell (PIC) simulations. It is found that the betatron frequency distribution function of a mismatched space-charge-dominated beam has a bump-on-tail structure attributed to the beam halo particles. Based on this observation, a new spectral method for halo particle definition is proposed that provides the opportunity to carry out a quantitative analysis of halo particle production by a beam mismatch. In addition, it is shown that the spectral analysis of the mismatch relaxation process provides important insights into the emittance growth attributed to the halo formation and the core relaxation processes. Finally, the spectral method is applied to the problem of space-charge transport limits.

  9. Modified MIS-structure based on nanoporous silicon with enhanced sensitivity to the hydrogen containing gases

    Energy Technology Data Exchange (ETDEWEB)

    Gorbanyuk, T.; Evtukh, A.; Litovchenko, V.; Solntsev, V. [Institute of Semiconductor Physics, Kiev (Ukraine)

    2008-07-01

    The gas sensitivity of metal-insulator-semiconductor (MIS)-structures based on nanoporous silicon with active electrodes from palladium/tungsten oxide composite has been studied. It was found that the using of palladium/tungsten oxide composite (instead of thin palladium film) leads to enhanced sensitivity of MIS structures to hydrogen sulphide in air. The mechanism of this phenomenon has been established. The enhanced H{sub 2}S sensitivity is explained in the following way. The microparticles of tungsten trioxide inside palladium matrix stimulate the dissociation of hydrogen sulphide molecules, and hydrogen atoms and/or protons flow down to palladium surface, are absorbed by palladium volume, diffuse to palladium/oxidized nanoporous silicon interface. Hydrogen atoms adsorbed at the interface are polarized and give rise to a dipole layer. As a result, the voltage shift of the capacity-voltage (C-V) curve proportional to the measured gas concentration is observed. The surface microstructure of Pd/WO{sub 3} composite was studied by AFM microscopy. The chemical content of the composite film has been investigated by SIMS. It was found that the composite film on nanoporous silicon surface poses the holes with the size about 0.05 {mu}m, the mean separation between tungsten oxide microparticles is 1-2 {mu}m. It also was found that the using of the additional double layer polymer film (polymer film (phthalocyanine zinc)/semicon-ductor film (cadmium sulphide)) on composite film surface leads to the additional enhancement of the gas sensitivity to hydrogen sulphide. (copyright 2008 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  10. Potential fluctuations due to randomly distributed charges at the semiconductor-insulator interface in mis-structures

    International Nuclear Information System (INIS)

    Yanchev, I; Slavcheva, G.

    1993-01-01

    A new expression for the Fourier transform of the binary correlation function of the random potential near the semiconductor-insulator interface is derived. The screening from the metal electrode in MIS-structure is taken into account introducing an effective insulator thickness. An essential advantage of this correlation function is the finite dispersion of the random potential Γ 2 to which it leads in distinction with the so far known correlation functions leading to divergent dispersion. The important characteristic of the random potential distribution Γ 2 determining the amplitude of the potential fluctuations is calculated. 7 refs. (orig.)

  11. 49 CFR 40.26 - What form must an employer use to report Management Information System (MIS) data to a DOT agency?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What form must an employer use to report Management Information System (MIS) data to a DOT agency? 40.26 Section 40.26 Transportation Office of the... Employer Responsibilities § 40.26 What form must an employer use to report Management Information System...

  12. A Single Base Pair Mutation Encoding a Premature Stop Codon in the MIS type II receptor is Responsible for Canine Persistent Müllerian Duct Syndrome

    Science.gov (United States)

    Wu, Xiufeng; Wan, Shengqin; Pujar, Shashikant; Haskins, Mark E.; Schlafer, Donald H.; Lee, Mary M.; Meyers-Wallen, Vicki N.

    2008-01-01

    Müllerian Inhibiting Substance (MIS), a secreted glycoprotein in the Transforming Growth Factor-beta (TGF-beta) family of growth factors, mediates regression of the Müllerian ducts during embryonic sex differentiation in males. In Persistent Müllerian Duct Syndrome (PMDS), rather than undergoing involution, the Müllerian ducts persist in males, giving rise to the uterus, Fallopian tubes, and upper vagina. Genetic defects in MIS or its receptor (MISRII) have been identified in patients with PMDS. The phenotype in the canine model of PMDS derived from the miniature schnauzer breed is strikingly similar to that of human patients. In this model, PMDS is inherited as a sex-limited autosomal recessive trait. Previous studies indicated that a defect in the MIS receptor or its downstream signaling pathway was likely to be causative of the canine syndrome. In this study the canine PMDS phenotype and clinical sequelae are described in detail. Affected and unaffected members of this pedigree are genotyped, identifying a single base pair substitution in MISRII that introduces a stop codon in exon 3. The homozygous mutation terminates translation at 80 amino acids, eliminating much of the extracellular domain and the entire transmembrane and intracellular signaling domains. Findings in this model may enable insights to be garnered from correlation of detailed clinical descriptions with molecular defects, which are not otherwise possible in the human syndrome. PMID:18723470

  13. Effect of the post-deposition annealing on electrical characteristics of MIS structures with HfO{sub 2}/SiO{sub 2} gate dielectric stacks

    Energy Technology Data Exchange (ETDEWEB)

    Taube, Andrzej [Institute of Electron Technology, Al. Lotnikow 32/46, 02-668 Warsaw (Poland); Institute of Microelectronics and Optoelectronics, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw (Poland); Mroczynski, Robert, E-mail: rmroczyn@elka.pw.edu.pl [Institute of Microelectronics and Optoelectronics, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw (Poland); Korwin-Mikke, Katarzyna [Institute of Electron Technology, Al. Lotnikow 32/46, 02-668 Warsaw (Poland); Gieraltowska, Sylwia [Institute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, 02-668 Warsaw (Poland); Szmidt, Jan [Institute of Microelectronics and Optoelectronics, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw (Poland); Piotrowska, Anna [Institute of Electron Technology, Al. Lotnikow 32/46, 02-668 Warsaw (Poland)

    2012-09-01

    In this work, we report on effects of post-deposition annealing on electrical characteristics of metal-insulator-semiconductor (MIS) structures with HfO{sub 2}/SiO{sub 2} double gate dielectric stacks. Obtained results have shown the deterioration of electro-physical properties of MIS structures, e.g. higher interface traps density in the middle of silicon forbidden band (D{sub itmb}), as well as non-uniform distribution and decrease of breakdown voltage (U{sub br}) values, after annealing above 400 Degree-Sign C. Two potential hypothesis of such behavior were proposed: the formation of interfacial layer between hafnia and silicon dioxide and the increase of crystallinity of HfO{sub 2} due to the high temperature treatment. Furthermore, the analysis of conduction mechanisms in investigated stacks revealed Poole-Frenkel (P-F) tunneling at broad range of electric field intensity.

  14. Biomarkers for IgA nephropathy on the basis of multi-hit pathogenesis.

    Science.gov (United States)

    Suzuki, Hitoshi

    2018-05-08

    IgA nephropathy (IgAN) is the most prevalent glomerular disease worldwide and is associated with a poor prognosis. Development of curative treatment strategies and approaches for early diagnosis is necessary. Renal biopsy is the gold standard for the diagnosis and assessment of disease activity. However, reliable biomarkers are needed for the noninvasive diagnosis of this disease and to more fully delineate the risk of progression. With regard to the pathogenesis of IgAN, the multi-hit hypothesis, including production of galactose-deficient IgA1 (Gd-IgA1; Hit 1), IgG or IgA autoantibodies that recognize Gd-IgA1 (Hit 2), and their subsequent immune complexes formation (Hit 3) and glomerular deposition (Hit 4), has been widely supported by many studies. Although the prognostic values of several biomarkers have been discussed, we recently developed a highly sensitive and specific diagnostic method by measuring serum levels of Gd-IgA1 and Gd-IgA1-containing immune complexes. In addition, urinary Gd-IgA1 may represent a disease-specific biomarker for IgAN. We also confirmed that there is a significant correlation between serum levels of these effector molecules and disease activity, suggesting that each can be considered a practical surrogate marker of therapeutic response. Thus, these disease-oriented specific serum and urine biomarkers may be useful for screening of potential IgAN with isolated hematuria, earlier diagnosis, disease activity, and eventually, response to treatment. In this review, we discuss these concepts, with a focus on potential clinical applications of these biomarkers.

  15. The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases.

    Science.gov (United States)

    Mori, Yoshiko; Masuda, Tomohiro; Kosugi, Tomoki; Yoshioka, Tomoki; Hori, Mayuko; Nagaya, Hiroshi; Maeda, Kayaho; Sato, Yuka; Kojima, Hiroshi; Kato, Noritoshi; Ishimoto, Takuji; Katsuno, Takayuki; Yuzawa, Yukio; Kadomatsu, Kenji; Maruyama, Shoichi

    2017-12-12

    Precise understanding of kidney disease activity is needed to design therapeutic strategies. CD147/basigin is involved in the pathogenesis of acute kidney injury and renal fibrosis through inflammatory cell infiltration. The present study examined the clinical relevance of CD147 in biopsy-proven kidney diseases that lead to the progression of chronic kidney disease. Kidney biopsy specimens and plasma and urine samples were obtained from patients with kidney diseases, including IgA nephropathy (IgAN), Henoch-Schönlein purpura nephritis (HSPN), diabetic kidney disease (DKD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN), who underwent renal biopsy between 2011 and 2014. Plasma and urinary CD147 levels were measured and evaluated for their ability to reflect histological features. Disease activity of IgAN tissues was evaluated according to the Oxford classification and the Japanese histological grading system. In biopsy tissues, CD147 induction was detected in injured lesions representing renal inflammation. Plasma CD147 values correlated with eGFR in patients with inflammation-related kidney diseases such as IgAN, HSPN, and DKD. Particularly in IgAN patients, plasma CD147 levels were correlated with injured regions comprising more than 50% of glomeruli or with tubular atrophy/interstitial injury in biopsy tissues. Proteinuria showed a closer correlation with urinary values of CD147 and L-FABP. Of note, plasma and urinary CD147 levels showed a strong correlation with eGFR or proteinuria, respectively, only in DKD patients. Evaluation of plasma and urinary CD147 levels might provide key insights for the understanding of the activity of various kidney diseases.

  16. Extended analysis of the frequency dependence of the admittance of MIS structures with pulsed-laser-deposited AlN films

    Energy Technology Data Exchange (ETDEWEB)

    Simeonov, S; Bakalova, S; Szekeres, A; Kafedjiijska, E [Georgi Nadjakov Institute of Solid State Physics, Bulgarian Academy of Sciences, 72 Tzarigradsko Chaussee, 1784 Sofia (Bulgaria); Grigorescu, S; Socol, G; Mihailescu, I N [Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, PO Box MG-54, RO-77125, Bucharest-Magurele (Romania)], E-mail: sbakalova@issp.bas.bg

    2008-05-01

    MIS structures with AlN films deposited on p-Si by pulsed laser deposition were prepared and admittance measurements were carried out in the frequency range of 100 Hz - 10 MHz. The density of traps in the AlN film and at the AlN/Si interface was evaluated using the electrical characteristics obtained, and the hopping mechanism of charge transport was determined from the dispersion of the a.c. conductance.

  17. Superstorms at the end of the Last Interglacial (MIS 5e)? Modeling paleo waves and the transport of giant boulders.

    Science.gov (United States)

    Rovere, Alessio; Harris, Daniel; Casella, Elisa; Lorscheid, Thomas; Stocchi, Paolo; Nandasena, Napayalage; Sandstrom, Michael; D'Andrea, William; Dyer, Blake; Raymo, Maureen

    2017-04-01

    We present the results of high-resolution field surveys and wave models along the cliffs of the northern part of the Island of Eleuthera, Bahamas. Previous studies have proposed that cliff top mega-boulders were emplaced at the end of the Last Interglacial (MIS 5e, 128-116 ka) by giant swells caused by super-storms that find no counterpart in the Holocene (including historical times). Our results suggest that these boulders could have instead been transported from the cliff face to the top of the cliff by a storm analogous to the 1991 'Perfect Storm', if sea level during MIS 5e sea was more than 4 meters higher than today. We remark that the data-model approach used here is essential to interpreting the geologic evidence of extreme storms during past warm periods, which in turn, is an important tool for predicting the intensity of extreme storm events in future climates. Our results indicate that even without an increase in storm intensity, cliffs and hard coastal barriers might be subject to significant increases wave-generated stresses under conditions of sea levels modestly higher than present.

  18. Temperature dependence of conductivity in high mobility MIS structures on a base of (001) silicon

    International Nuclear Information System (INIS)

    Vyrodov, E.A.; Dolgopolov, V.T.; Dorozhkin, C.I.; Zhitenev, N.B.

    1988-01-01

    Measurements of the temperature dependence of the conductivity of two-dimensional electrons in silicon MIS structures were carried out. It is shown that the observed dependence is well described by the equation σ(T) = σ(0)(1-Q(kT var-epsilon F )-P(kT/var-epsilon F )3/2 + O[(kT/var-epsilon F ) 2 ]). The variation of the coefficient Q with the density N S of the two-dimensional electrons is determined, and it is shown that the observed trend of the Q(s) curve is described by consideration of the temperature dependence of the dielectric function of a two-dimensional electron gas

  19. Groove-type channel enhancement-mode AlGaN/GaN MIS HEMT with combined polar and nonpolar AlGaN/GaN heterostructures

    International Nuclear Information System (INIS)

    Duan Xiao-Ling; Zhang Jin-Cheng; Xiao Ming; Zhao Yi; Ning Jing; Hao Yue

    2016-01-01

    A novel groove-type channel enhancement-mode AlGaN/GaN MIS high electron mobility transistor (GTCE-HEMT) with a combined polar and nonpolar AlGaN/GaN heterostucture is presented. The device simulation shows a threshold voltage of 1.24 V, peak transconductance of 182 mS/mm, and subthreshold slope of 85 mV/dec, which are obtained by adjusting the device parameters. Interestingly, it is possible to control the threshold voltage accurately without precisely controlling the etching depth in fabrication by adopting this structure. Besides, the breakdown voltage ( V B ) is significantly increased by 78% in comparison with the value of the conventional MIS-HEMT. Moreover, the fabrication process of the novel device is entirely compatible with that of the conventional depletion-mode (D-mode) polar AlGaN/GaN HEMT. It presents a promising way to realize the switch application and the E/D-mode logic circuits. (paper)

  20. The effect of {sup 60}Co ({gamma}-ray) irradiation on the electrical characteristics of Au/SnO{sub 2}/n-Si (MIS) structures

    Energy Technology Data Exchange (ETDEWEB)

    Goekcen, M. [Physics Department, Faculty of Arts and Sciences, Gazi University, 06500 Teknikokullar, Ankara (Turkey); Tataroglu, A. [Physics Department, Faculty of Arts and Sciences, Gazi University, 06500 Teknikokullar, Ankara (Turkey)], E-mail: ademt@gazi.edu.tr; Altindal, S.; Buelbuel, M.M. [Physics Department, Faculty of Arts and Sciences, Gazi University, 06500 Teknikokullar, Ankara (Turkey)

    2008-01-15

    The effect of {sup 60}Co ({gamma}-ray) irradiation on the electrical properties of Au/SnO{sub 2}/n-Si (MIS) structures has been investigated using the capacitance-voltage (C-V) and conductance-voltage (G/{omega}-V) measurements in the frequency range 1 kHz to 1 MHz at room temperature. The MIS structures were exposed to {gamma}-rays at a dose rate of 2.12 kGy/h in water and the range of total dose was 0-500 kGy. It was found that the C-V and G/{omega}-V curves were strongly influenced with both frequency and the presence of the dominant radiation-induced defects, and the series resistance was increased with increasing dose. Also, the radiation-induced threshold voltage shift ({delta}V{sub T}) strongly depended on radiation dose and frequency, and the density of interface states N{sub ss} by Hill-Coleman method decreases with increasing radiation dose.

  1. The use of a virtual reality simulator to explore and understand the impact of Linac mis-calibrations

    Science.gov (United States)

    Beavis, Andrew W.; Ward, James W.

    2014-03-01

    Purpose: In recent years there has been interest in using Computer Simulation within Medical training. The VERT (Virtual Environment for Radiotherapy Training) system is a Flight Simulator for Radiation Oncology professionals, wherein fundamental concepts, techniques and problematic scenarios can be safely investigated. Methods: The system provides detailed simulations of several Linacs and the ability to display DICOM treatment plans. Patients can be mis-positioned with 'set-up errors' which can be explored visually, dosimetrically and using IGRT. Similarly, a variety of Linac calibration and configuration parameters can be altered manually or randomly via controlled errors in the simulated 3D Linac and its component parts. The implication of these can be investigated by following through a treatment scenario or using QC devices available within a Physics software module. Results: One resultant exercise is a systematic mis-calibration of 'lateral laser height' by 2mm. The offset in patient alignment is easily identified using IGRT and once corrected by reference to the 'in-room monitor'. The dosimetric implication is demonstrated to be 0.4% by setting a dosimetry phantom by the lasers (and ignoring TSD information). Finally, the need for recalibration can be shown by the Laser Alignment Phantom or by reference to the front pointer. Conclusions: The VERT system provides a realistic environment for training and enhancing understanding of radiotherapy concepts and techniques. Linac error conditions can be explored in this context and valuable experience gained in a controlled manner in a compressed period of time.

  2. Summary of the Snowmastodon Project Special Volume. A high-elevation, multi-proxy biotic and environmental record of MIS 6-4 from the Ziegler Reservoir fossil site, Snowmass Village, Colorado, USA

    Science.gov (United States)

    Miller, Ian M.; Pigati, Jeffrey S.; Scott Anderson, R.; Johnson, Kirk R.; Mahan, Shannon A.; Ager, Thomas A.; Baker, Richard G.; Blaauw, Maarten; Bright, Jordon; Brown, Peter M.; Bryant, Bruce; Calamari, Zachary T.; Carrara, Paul E.; Cherney, Michael D.; Demboski, John R.; Elias, Scott A.; Fisher, Daniel C.; Gray, Harrison J.; Haskett, Danielle R.; Honke, Jeffrey S.; Jackson, Stephen T.; Jiménez-Moreno, Gonzalo; Kline, Douglas; Leonard, Eric M.; Lifton, Nathaniel A.; Lucking, Carol; Gregory McDonald, H.; Miller, Dane M.; Muhs, Daniel R.; Nash, Stephen E.; Newton, Cody; Paces, James B.; Petrie, Lesley; Plummer, Mitchell A.; Porinchu, David F.; Rountrey, Adam N.; Scott, Eric; Sertich, Joseph J. W.; Sharpe, Saxon E.; Skipp, Gary L.; Strickland, Laura E.; Stucky, Richard K.; Thompson, Robert S.; Wilson, Jim

    2014-11-01

    In North America, terrestrial records of biodiversity and climate change that span Marine Oxygen Isotope Stage (MIS) 5 are rare. Where found, they provide insight into how the coupling of the ocean-atmosphere system is manifested in biotic and environmental records and how the biosphere responds to climate change. In 2010-2011, construction at Ziegler Reservoir near Snowmass Village, Colorado (USA) revealed a nearly continuous, lacustrine/wetland sedimentary sequence that preserved evidence of past plant communities between ~ 140 and 55 ka, including all of MIS 5. At an elevation of 2705 m, the Ziegler Reservoir fossil site also contained thousands of well-preserved bones of late Pleistocene megafauna, including mastodons, mammoths, ground sloths, horses, camels, deer, bison, black bear, coyotes, and bighorn sheep. In addition, the site contained more than 26,000 bones from at least 30 species of small animals including salamanders, otters, muskrats, minks, rabbits, beavers, frogs, lizards, snakes, fish, and birds. The combination of macro- and micro-vertebrates, invertebrates, terrestrial and aquatic plant macrofossils, a detailed pollen record, and a robust, directly dated stratigraphic framework shows that high-elevation ecosystems in the Rocky Mountains of Colorado are climatically sensitive and varied dramatically throughout MIS 5.

  3. The ESA Mice in Space (MIS) habitat: effects of cage confinement on neuromusculoskeletal structure and function and stress/behavior using wild-type C57Bl/6JRj mice in a modular science reference model (MSRM) test on ground

    Science.gov (United States)

    Blottner, Dieter; Vico, Laurence; Jamon, D. Berckmansp L. Vicop Y. Liup R. Canceddap M.

    Background: Environmental conditions likely affect physiology and behaviour of mice used for Life Sciences Research on Earth and in Space. Thus, mice habitats with sufficient statistical numbers should be developed for adequate life support and care and that should meet all nesces-sary ethical and scientific requirements needed to successfully perform animal experimentation in Space. Aim of study: We here analysed the effects of cage confinement on the weightbear-ing musculoskeletal system, behaviour and stress of wild-type mice (C57BL/6JRj, 30 g b.wt., total n = 24) housed for 25 days in a prototypical ground-based MSRM (modular science ref-erence module) in the frame of breadboard activities for a fully automated life support habitat called "Mice in Space" (MIS) at the Leuven University, Belgium. Results: Compared with control housing (individually ventilated cages, IVC-mice) the MIS mice revealed no significant changes in soleus muscle size and myofiber distribution (type I vs. II) and quality of bone (3-D microarchitecture and mineralisation of calvaria, spine and femur) determined by confocal and micro-computed tomography. Corticosterone metabolism measured non-invasively (faeces) monitored elevated adrenocortical activity at only start of the MIS cage confinement (day 1). Behavioural tests (i.e., grip strength, rotarod, L/D box, elevated plus-maze, open field, ag-gressiveness) performed subsequently revealed only minor changes in motor performance (MIS vs. controls). Conclusions: The MIS habitat will not, on its own, produce major effects that could confound interpretation of data induced by microgravity exposure on orbit as planned for future biosatellite programmes. Sponsors: ESA-ESTEC, Noordwijk, NL

  4. Iceberg and meltwater discharge events in the western Arctic Ocean since MIS 5: a comparison of sediment cores off the East Siberian and Chukchi margins

    Science.gov (United States)

    Xiao, W.; Wang, R.; Zhang, T.; Duan, X.; Polyak, L.

    2017-12-01

    In the Pleistocene the western Arctic Ocean was affected by deglacial discharge events from ice sheets in northern North America as well as the East Siberian and Chukchi margins. Distribution of Ice Rafted Debris (IRD) >250 μm and planktonic foraminiferal N. pachyderma (sin.) (Nps) δ18O and δ13C was compared in CHINARE sediment cores ARC2-M03 (Wang et al., 2013) and ARC3-P37 from the Chukchi Abyssal Plain and Northwind Ridge, respectively, to identify the impacts of icebergs and meltwater on paleoceanographic environments since MIS 5. The IRD is mainly composed of quartz grains and fragments of clastic rocks and detrital carbonates. The carbonates, mostly dolomites characteristic of the Canadian Arctic Archipelago (CAA) provenance, typically anti-correlate with quartz and clastic rocks, indicating different sources such as Chukchi-Alaskan or East Siberian margin. Most of the Nps δ18O depletions correspond to peaks in detrital carbonates, suggesting a strong influence of meltwater from the Laurentide Ice Sheet (LIS) on the western Arctic Ocean. A conspicuous dark gray interval interpreted to represent glacial/deglacial environments of MIS 4/3 age, shows a remarkable depletion in Nps δ13C along with high δ18O values and absence of IRD. This unusual signature may be related to a persistent sea-ice cover and/or high fluxes of terrigenous material with deglacial debris flows. In a younger grey interval corresponding to MIS2, high abundances of quartz and clastic rocks in the Northwind Ridge core ARC3-P37 indicate iceberg discharge from areas other than CAA, such as the Mackenzie LIS lobe or Chukchi-Alaskan margin. The MIS2-Holocene transition is marked by an increase in detrital carbonates co-occurring with Nps δ13C and δ18O depletion (Polyak et al., 2007), indicative of LIS iceberg/meltwater fluxes from the CAA. We note that stable-isotope events in the study area may go unnoticed because of gaps in foraminiferal records related to dissolution and/or adverse

  5. Changes in the clinical presentation of immunoglobulin A nephropathy: data from the Spanish Registry of Glomerulonephritis.

    Science.gov (United States)

    Gutiérrez, Eduardo; Praga, Manuel; Rivera, Francisco; Sevillano, Angel; Yuste, Claudia; Goicoechea, Marian; López-Gómez, Juan M

    2018-03-01

    Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis in the world, but there is little epidemiological data about possible changes in its presentation over the years. Available information about the influence of age on the form of clinical presentation is also scarce. The aim of the study was to analyse all renal biopsies performed between 1994 and 2013 and recorded in the Spanish Registry of Glomerulonephritis with a histological diagnosis of IgAN. The study was divided into five 4-year periods (1994-97, 1998-2001, 2002-05, 2006-09 and 2010-13) and patients were divided into four age groups: ≤16, 17-44, 45-64 and ≥65 years. From 20.974 renal biopsies recorded, 2961 (14.1%) corresponded to IgAN. The prevalence of IgAN remained stable, but a significant increase in age [from 37.6 (SD 17.7) in 1994-97 to 44.9 (SD 16.8) years in 2010-13; P = 0.001] and worse renal function at presentation [from serum creatinine (SCr) 1.9 (SD 1.9) in 1994-97 to 2.3 (SD 2.1) mg/dL in 2010-13; P = 0.001] were observed over the years. Nephrotic-range proteinuria and acute kidney injury (AKI) as forms of presentation were significantly more common among patients ≥65 years (17.7% and 43.2%, respectively) as compared with the other age groups [≤16 (11.4% and 13.1%, respectively), 17-44 (13.1% and 13%, respectively) and 45-64 (12.1% and 21.3%, respectively)]. Blood pressure, SCr and proteinuria were also significantly higher at presentation among elderly patients. Although the prevalence of IgAN in Spain has remained stable over the years, patients are significantly older and present with significantly worse renal function in the last years. The incidence of nephrotic-range proteinuria (17.7%) and AKI (43.2%) as forms of presentation is remarkable among patients ≥65 years of age. © The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

  6. Experimental J estimation from a load-cmod curve for mis-matched SENB and CCT specimens

    International Nuclear Information System (INIS)

    Hornet, P.; Eripret, Ch.; Hao, S.

    1997-01-01

    This paper addresses the problem of the determination of the J-integral from experimentally measured quantities for mismatched Single Notched Bend specimens (SENB) or through thickness Centre Cracked panels loaded in Tension (CCT). Commonly, the experimental J-integral is calculated from the area under the load versus load-line displacement curve. Nevertheless, in the case of gross-section yielding, which can occur for short cracked specimens or overmatching cases, this methodology mis-estimates the effective J-integral. A new proposal, based on analytical considerations is made to estimate the J-integral from the area under load versus CMOD curves. This proposal is validated by 2D and 3D finite element analyses. (authors)

  7. Study on the low leakage current of an MIS structure fabricated by ICP-CVD

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, S-Y; Hon, M-H [Department of Materials Science and Engineering, National Cheng Kung University, 1, Ta-Hsueh Road, Tainan, 701 Taiwan (China); Lu, Y-M, E-mail: ymlumit@yahoo.com.tw

    2008-03-15

    As the dimensions of electric devices continue to shrink, it is becoming increasingly important to understand how to obtain good quality gate oxide film materials wilth higher carrier mobility, lower leakage current and greater reliability. All of them have become major concerns in the fabrication of thin film oxide transistors. A novel film deposition method called Inductively Coupled Plasma-Chemical Vapor Deposition (ICP-CVD) has received attraction in the semiconductor industry, because it can be capable of generating high density plasmas at extremely low temperature, resulting in less ion bombardment of the material surface. In this work, we present the results of crystallized silicon dioxide films deposited by inductively coupled plasma chemical vapor deposition technique at an extremely low temperature of 90 deg. C. The value of the refractive index of the crystallized ICP-CVD SiO{sub 2} film depends on the r.f. power of the ICP system, and approximates to be 1.46. This value is comparable to that of SiO{sub 2} films prepared by thermal oxidation. As the r.f. power of ICP applied more than 1250 Watts, still only the (111) diffraction peak is observed by XRD, which implies a very strong preferred orientation or single crystal structure. Too low or too high r.f. power both produces amorphous SiO{sub 2} films. From the I-V curve, the MIS device with a SiO{sub 2} dielectric film has a lower leakage current density of 6.8x10{sup -8}A/cm{sup 2} at 1V as the film prepared at 1750 watts. The highest breakdown field in this study is 15.8 MV/cm. From the FTIR analysis, it was found that more hydrogen atoms incorporate into films and form Si-OH bonds as the r.f. power increases. The existence of Si-OH bonds leads to a poor reliability of the MIS device.

  8. The use of a virtual reality simulator to explore and understand the impact of Linac mis-calibrations

    International Nuclear Information System (INIS)

    Beavis, Andrew W; Ward, James W

    2014-01-01

    Purpose: In recent years there has been interest in using Computer Simulation within Medical training. The VERT (Virtual Environment for Radiotherapy Training) system is a Flight Simulator for Radiation Oncology professionals, wherein fundamental concepts, techniques and problematic scenarios can be safely investigated. Methods: The system provides detailed simulations of several Linacs and the ability to display DICOM treatment plans. Patients can be mis-positioned with 'set-up errors' which can be explored visually, dosimetrically and using IGRT. Similarly, a variety of Linac calibration and configuration parameters can be altered manually or randomly via controlled errors in the simulated 3D Linac and its component parts. The implication of these can be investigated by following through a treatment scenario or using QC devices available within a Physics software module. Results: One resultant exercise is a systematic mis-calibration of 'lateral laser height' by 2mm. The offset in patient alignment is easily identified using IGRT and once corrected by reference to the 'in-room monitor'. The dosimetric implication is demonstrated to be 0.4% by setting a dosimetry phantom by the lasers (and ignoring TSD information). Finally, the need for recalibration can be shown by the Laser Alignment Phantom or by reference to the front pointer. Conclusions: The VERT system provides a realistic environment for training and enhancing understanding of radiotherapy concepts and techniques. Linac error conditions can be explored in this context and valuable experience gained in a controlled manner in a compressed period of time.

  9. Potential fluctuations due to the randomly distributed charges at the semiconductor-insulator interface in MIS-structures

    International Nuclear Information System (INIS)

    Slavcheva, G.; Yanchev, I.

    1991-01-01

    A new expression for the Fourier transform of the binary correlation function of the random potential near the semiconductor-insulator interface is derived. The screening due to the image charge with respect to the metal electrode in MIS-structure is taken into account, introducing an effective insulator thickness. An essential advantage of this correlation function is the finite dispersion of the random potential Γ 2 to which it leads in distinction with the so far known correlation functions leading to divergent dispersion. The important characteristic of the random potential distribution Γ 2 determining the amplitude of the potential fluctuations is calculated. (author). 7 refs, 1 fig

  10. Influence of 60Co γ-ray irradiation and applied bias voltages on dielectric properties of Al/SiO2/p-Si (MIS) structures

    International Nuclear Information System (INIS)

    Tascioglu, I.; Uslu, H.; Aydemir, U.

    2010-01-01

    The MIS structures were exposed to 6 0Co γ-ray source at 5 kGy and radiation effect on dielectric properties has been investigated using admittance method (C-V and G/ω-V) by applying a small ac signal of 40 mV amplitude at 1 MHz and room temperature. The voltage dependent dielectric constant (ε'), dielectric loss (ε''), loss tangent (tanδ), electric modulus(M*) and ac electrical conductivity (σ a c) profiles show an intersection behavior about 1.6 V. The ε', ε'', tanδ and σ a c values decrease with increasing dose before intersection point after than they become increase. Such behavior can be explained on the basis of Maxwell-Wagner interfacial polarization and restructuring and reordering of interface states charges due to the effect of γ-ray irradiation. Also, the imaginer part of M* exhibits a peak. It is concluded that all these parameters of MIS structure are strongly dependent on the radiation dose and applied bias voltage especially in depletion region.

  11. Self-associating autotransporters, SAATs

    DEFF Research Database (Denmark)

    Klemm, Per; Vejborg, Rebecca Munk; Sherlock, O.

    2006-01-01

    The autotransporter family of translocated proteins in Gram-negative bacteria all contain three structural motifs, a signal sequence, a passenger domain and a translocator domain. The autotransporters constitute a highly versatile group of proteins with respect to function, which accords with the...

  12. Etenduskunsti eetikast / Mari Saat

    Index Scriptorium Estoniae

    Saat, Mari, 1947-

    2007-01-01

    Pärnu nüüdiskunsti festivalil toimunud performance'i ja seal esinenud Eesti rahvusmeeskoori konfliktist. Näituse "Kehaturg" avamisel toimunud performance'ist "Kadalipp". Kommenteerivad Andrus Kallastu, Al paldrok, Ville-Karel Viirelaiu ja Sandra Jõgeva

  13. Sotsiaalne kompetentsus / Helve Saat

    Index Scriptorium Estoniae

    Saat, Helve

    2004-01-01

    Sotsiaalsete oskuste puudulikkuse tõttu on paljudel koolilastel probleeme suhtlemisel eakaaslaste ja täiskasvanutega. Siit võib leida antisotsiaalse käitumise, vägivalla ja uimastite tarvitamise, samuti koolikiusamise ning tõrjutuse põhjusi

  14. The influence of the isolating and the intermediate layer in the photovoltaic presentation of a M.I.S. structure calculation of optimal parameters

    International Nuclear Information System (INIS)

    Viktorovitch, P.; Kamarinos, G.; Even, P.

    1976-01-01

    A photovoltaic MIS structure is examined. The fundamental function of the isolating layer and the contribution of the intermidiate layer for efficiency improvement, are shown. The undertaking illustrates that there is an optimal thickness for the intermidiary layer. With the aid of basic equations, the thickness is calculated and the results are given for silicon. (ORU) [de

  15. Civacuve analysis software for mis machine examination of pressurized water reactor vessels; Civacuve logiciel d'analyse des controles mis des cuves de reacteurs nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, Ph.; Gagnor, A. [Intercontrole, 94 - Rungis (France)

    2001-07-01

    The product software CIVACUVE is used by INTERCONTROLE for the analysis of UT examinations, for detection, performed by the In-Service Inspection Machine (MIS) of the vessels of nuclear power plants. This software is based on an adaptation of an algorithm of SEGMENTATION (CEA CEREM), which is applied prior to any analysis. It is equipped with tools adapted to industrial use. It allows to: - perform image analysis thanks to advanced graphic tools (Zooms, True Bscan, 'contour' selection...), - backup of all data in a database (complete and transparent backup of all informations used and obtained during the different analysis operations), - connect PC to the Database (export of Reports and even of segmented points), - issue Examination Reports, Operating Condition Sheets, Sizing curves... - and last, perform a graphic and numerical comparison between different inspections of the same vessel. Used in Belgium and France on different kind of reactor vessels, CIVACUVE has allowed to show that the principle of SEGMENTATION can be adapted to detection exams. The use of CIVACUVE generates a important time gain as well as the betterment of quality in analysis. Wide data opening toward PC's allows a real flexibility with regard to client's requirements and preoccupations.

  16. Stability of polarization in organic ferroelectric metal-insulator-semiconductor (MIS) structures

    Energy Technology Data Exchange (ETDEWEB)

    Kalbitz, Rene; Fruebing, Peter; Gerhard, Reimund [Department of Physics and Astronomy, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476, Potsdam (Germany); Taylor, Martin [School of Electronic Engineering, Bangor University, Dean Street, Bangor Gwynedd, LL57 1UT (United Kingdom)

    2011-07-01

    Ferroelectric field effect transistors (FeFETs) offer the prospect of an organic-based memory device. Since the charge transport in such devices is confined to the interface between the insulator and the semiconductor, the focus of the present study was on the investigation of this region. Capacitance-voltage (C-V) measurements of all-organic MIS devices with poly(vinylidenefluoride- trifluoroethylene) (P(VDF-TrFE)) as gate insulator and poly(3-hexylthiophene)(P3HT) as semiconductor were carried out. When the structure was driven into depletion, a positive flat-band voltage shift was observed arising from the change in polarization state of the ferroelectric insulator. When driven into accumulation, the polarization was reversed. It is shown that both polarization states are stable. However, negative charge trapped at the interface during the depletion cycle masks the negative shift in flat-band voltage expected during the sweep to accumulation voltages. Measurements on P(VDF-TrFE)/P3HT based FeFETs yield further evidence for fixed charges at the interface. Output characteristics suggest the injection of negative charges into the interface region when a depletion voltage is applied between source and gate contact.

  17. Discriminative power of fatty acid methyl ester (FAME) analysis using the microbial identification system (MIS) for Candida (Torulopsis) glabrata and Saccharomyces cerevisiae.

    Science.gov (United States)

    Peltroche-Llacsahuanga, H; Schmidt, S; Lütticken, R; Haase, G

    2000-12-01

    Candida (Torulopsis) glabrata is frequently isolated in cases of fungal infection and commonly shows acquired or innate fluconazole resistance. Saccharomyces cerevisiae, an emerging opportunistic yeast pathogen, causes serious systemic infections in immunocompromised, and vaginitis and superficial infections in immunocompetent patients. For both species reliable identification in the routine laboratory is mandatory, but species identification of strains, e.g. trehalose-negative C. glabrata, may be difficult. Therefore, gas-liquid chromatography (GLC) of whole cell fatty acid methyl ester (FAME) profiles, that is independent of assimilation profiles of strains and suitable for reliable and rapid identification of clinically important yeasts, was applied. However, frequent misidentification of C. glabrata as S. cerevisiae has been reported when using the Yeast Clinical Database of MIS. Accuracy of MIS identification may be strongly influenced by the amounts of cell mass analyzed. Therefore, the present study compared the MIS results of these two yeasts achieved with different cell masses. Primarily we optimized, especially with respect to cost-effectiveness, the recommended streaking technique yielding a maximal recovery of 90-130 mg of cell mass from one plate, enabling testing of poor growing strains of C. glabrata. For all C. glabrata strains tested (n = 10) the highest identification scores (SI [Similarity Index] range 0.525-0.963, median 0.832) were achieved with 30 to 45 mg of cell mass. Only 5 of 10 S. cerevisiae strains revealed good library comparisons (SI > or = 0.5) when using 30 mg of cell mass, whereas with 45 mg all strains but two revealed this SI-level. For S. cerevisiae a higher amount of cell mass processed (up to 90 mg) was correlated with better identification scores (SI range using 90 mg: 0.464-0.870, median, 0.737). Several passages prior to FAME analysis of C. glabrata strains on recommended media revealed narrowing of SI ranges, but

  18. Effect of annealing temperature on the electrical properties of Au/Ta{sub 2}O{sub 5}/n-GaN metal-insulator-semiconductor (MIS) structure

    Energy Technology Data Exchange (ETDEWEB)

    Prasanna Lakshmi, B.; Rajagopal Reddy, V.; Janardhanam, V. [Sri Venkateswara University, Department of Physics, Tirupati (India); Siva Pratap Reddy, M.; Lee, Jung-Hee [Kyungpook National University, School of Electrical Engineering and Computer Science, Daegu (Korea, Republic of)

    2013-11-15

    We report on the effect of an annealing temperature on the electrical properties of Au/Ta{sub 2}O{sub 5}/n-GaN metal-insulator-semiconductor (MIS) structure by current-voltage (I-V) and capacitance-voltage (C-V) measurements. The measured Schottky barrier height ({Phi} {sub bo}) and ideality factor n values of the as-deposited Au/Ta{sub 2}O{sub 5}/n-GaN MIS structure are 0.93 eV (I-V) and 1.19. The barrier height (BH) increases to 1.03 eV and ideality factor decreases to 1.13 upon annealing at 500 {sup circle} C for 1 min under nitrogen ambient. When the contact is annealed at 600 {sup circle} C, the barrier height decreases and the ideality factor increases to 0.99 eV and 1.15. The barrier heights obtained from the C-V measurements are higher than those obtained from I-V measurements, and this indicates the existence of spatial inhomogeneity at the interface. Cheung's functions are also used to calculate the barrier height ({Phi} {sub bo}), ideality factor (n), and series resistance (R{sub s}) of the Au/Ta{sub 2}O{sub 5}/n-GaN MIS structure. Investigations reveal that the Schottky emission is the dominant mechanism and the Poole-Frenkel emission occurs only in the high voltage region. The energy distribution of interface states is determined from the forward bias I-V characteristics by taking into account the bias dependence of the effective barrier height. It is observed that the density value of interface states for the annealed samples with interfacial layer is lower than that of the density value of interface states of the as-deposited sample. (orig.)

  19. Predictors of outcome for severe IgA Nephropathy in a multi-ethnic U.S. cohort.

    Science.gov (United States)

    Arroyo, Ana Huerta; Bomback, Andrew S; Butler, Blake; Radhakrishnan, Jai; Herlitz, Leal; Stokes, M Barry; D'Agati, Vivette; Markowitz, Glen S; Appel, Gerald B; Canetta, Pietro A

    2015-09-01

    Although IgA nephropathy (IgAN) is the leading cause of glomerulonephritis worldwide, there are few large cohorts representative of U.S. Prognosis remains challenging, particularly as more patients are treated with RAAS blockade and immunosuppression. We analyzed a retrospective cohort of IgAN patients followed at Columbia University Medical Center from 1980 to 2010. We evaluated two outcomes - halving of eGFR and ESRD - using three proportional hazards models: 1) a model with only clinical parameters, 2) a model with only histopathologic parameters, and 3) a model combining clinical and histopathologic parameters. Of 154 patients with biopsy-proven IgAN, 126 had follow-up data available and 93 had biopsy slides re-read. Median follow-up was 47 months. The cohort was 64% male, 60% white, and the average age was 34 years at diagnosis. Median (IQR) eGFR and proteinuria at diagnosis were 64.1 (38.0 - 88.7) mL/min/1.73 m2 and 2.7 (1.3 - 4.5) g/day. Over 90% of subjects were treated with RAAS blockade, and over 66% received immunosuppression. In the clinical parameters-only model, baseline eGFR and African-American race predicted both halving of eGFR and ESRD. In the histopathologic parameters-only model, no parameter significantly predicted outcome. In the combined model, baseline eGFR remained the strongest predictor of both halving of eGFR (p = 0.03) and ESRD (p = 0.001), while the presence of IgG by immunofluorescence microscopy also predicted progression to ESRD. In this diverse U.S. IgAN cohort in which the majority of patients received RAAS blockade and immunosuppression, baseline eGFR, African-American race, and co-staining of IgG predicted poor outcome.

  20. Denture Mis-swallowing in the Sliding Esophageal Hiatal Hernia Mimics Esophageal Perforation

    Directory of Open Access Journals (Sweden)

    Chao-Yang Chen

    2008-08-01

    Full Text Available Mis-swallowing of a foreign body in the esophagus coexisting with sliding hernia might be misdiagnosed as esophageal perforation with mediastinal abscess. We report an 89-year-old woman, bedridden for a long period in a nursing home after a previous cerebrovascular accident, who was sent to our emergency department in a state of sepsis because she had swallowed a radio-opaque partial denture. The retention of the denture as an esophageal foreign body was complicated with mediastinitis and bilateral pleural effusion. The inability of the patient to give a reliable clinical history delayed the diagnosis. This report highlights the difficulty in precisely locating a partial denture because of conflicting radiologic findings and the coexistence of esophageal sliding hernia, all of which led to a misdiagnosis of possible esophageal perforation. A right posterolateral thoracotomy with gastrostomy was performed to remove the lower esophageal foreign body after esophagoscopy failed. The surgical finding of a coincidental sliding esophageal hiatal hernia correlated well with the clinical presentation. Managing such a complicated esophageal foreign body in this elderly patient was challenging.

  1. MIS High-Purity Plutonium Oxide Hydride Product 5501579 (SSR124): Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Veirs, Douglas Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stroud, Mary Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Berg, John M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Narlesky, Joshua Edward [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Worl, Laura Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Martinex, Max A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carillo, Alex [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2018-02-08

    A high-purity plutonium dioxide material from the Material Identification and Surveillance (MIS) Program inventory has been studied with regard to gas generation and corrosion in a storage environment. Sample 5501579 represents process plutonium oxides from hydride oxide from Rocky Flats that are currently stored in 3013 containers. After calcination to 950°C, the material contained 87.42% plutonium with no major impurities. This study followed over time, the gas pressure of a sample with nominally 0.5 wt% water in a sealed container with an internal volume scaled to 1/500th of the volume of a 3013 container. Gas compositions were measured periodically over a six year period. The maximum observed gas pressure was 124 kPa. The increase over the initial pressure of 70 kPa was primarily due to generation of nitrogen and carbon dioxide gas. Hydrogen and oxygen were minor components of the headspace gas. At the completion of the study, the internal components of the sealed container showed signs of corrosion.

  2. Sub-decadal- to decadal-scale climate cyclicity during the Holsteinian interglacial (MIS 11 evidenced in annually laminated sediments

    Directory of Open Access Journals (Sweden)

    A. Koutsodendris

    2011-09-01

    Full Text Available To unravel the short-term climate variability during Marine Isotope Stage (MIS 11, which represents a close analogue to the Holocene with regard to orbital boundary conditions, we performed microfacies and time series analyses on a ~3200-yr-long record of annually laminated Holsteinian lake sediments from Dethlingen, northern Germany. These biogenic varves comprise two sub-layers: a light sub-layer, which is controlled by spring/summer diatom blooms, and a dark sub-layer consisting mainly of amorphous organic matter and fragmented diatom frustules deposited during autumn/winter. Time series analyses were performed on the thickness of the light and dark sub-layers. Signals exceeding the 95% and 99% confidence levels occur at periods that are near-identical to those known from modern instrumental data and Holocene palaeoclimatic records. Spectral peaks at periods of 90, 25, and 10.5 yr are likely associated with the 88-, 22- and 11-yr solar cycles, respectively. This variability is mainly expressed in the light sub-layer spectra, suggesting solar influence on the palaeoproductivity of the lake. Significant signals at periods between 3 and 5 yr and at ∼6 yr are strongest expressed in the dark sub-layer spectra and may reflect an influence of the El Niño-Southern Oscillation (ENSO and the North Atlantic Oscillation (NAO during autumn/winter. Our results suggest that solar forcing and ENSO/NAO-like variability influenced central European climate during MIS 11 similarly to the present interglacial, thus demonstrating the comparability of the two interglacial periods at sub-decadal to decadal timescales.

  3. Exploring the MIS M2 glaciation occurring during a warm and high atmospheric CO2 Pliocene background climate

    Science.gov (United States)

    Tan, Ning; Ramstein, Gilles; Dumas, Christophe; Contoux, Camille; Ladant, Jean-Baptiste; Sepulchre, Pierre; Zhang, Zhongshi; De Schepper, Stijn

    2017-08-01

    Prior to the Northern Hemisphere glaciation around ∼2.7 Ma, a large global glaciation corresponding to a 20 to 60 m sea-level drop occurred during Marine Isotope Stage (MIS) M2 (3.312-3.264 Ma), interrupted the period of global warmth and high CO2 concentration (350-450 ppmv) of the mid Piacenzian. Unlike the late Quaternary glaciations, the M2 glaciation only lasted 50 kyrs and occurred under uncertain CO2 concentration (220-390 ppmv). The mechanisms causing the onset and termination of the M2 glaciation remain enigmatic, but a recent geological hypothesis suggests that the re-opening and closing of the shallow Central American Seaway (CAS) might have played a key role. In this article, thanks to a series of climate simulations carried out using a fully coupled Atmosphere Ocean General Circulation Model (GCM) and a dynamic ice sheet model, we show that re-opening of the shallow CAS helps precondition the low-latitude oceanic circulation and affects the related northward energy transport, but cannot alone explain the onset of the M2 glaciation. The presence of a shallow open CAS, together with favourable orbital parameters, 220 ppmv of CO2 concentration, and the related vegetation and ice sheet feedback, led to a global ice sheet build-up producing a global sea-level drop in the lowest range of proxy-derived estimates. More importantly, our results show that the simulated closure of the CAS has a negligible impact on the NH ice sheet melt and cannot explain the MIS M2 termination.

  4. Electronic and interface state density properties of Cu/n-Si MIS-type diode

    Energy Technology Data Exchange (ETDEWEB)

    Yakuphanoglu, Fahrettin [Physics Department, Firat University, Elazig 23169 (Turkey)]. E-mail: fyhanoglu@firat.edu.tr

    2007-05-01

    Electronic and interface-state density properties of the Cu/n-Si diode were investigated by current-voltage and capacitance-voltage (C-V) analyses. The electronic parameters such as barrier height, ideality factor and series resistance of the diode were determined by performing different plots. The barrier height, ideality factor and series resistance values of the diode were found to be 0.69 eV, 5.31 and 7.63 k{omega}, respectively. The obtained ideality factor confirms that the Cu/n-Si device has a metal-insulator-semiconductor (MIS) configuration. The conductance mechanism of the Cu/n-Si diode is in agreement with typical of hopping conduction in polycrystalline and amorphous materials. The interface state density of the diode was found to vary from 1.45x10{sup 13} (eV{sup -1} cm{sup 2}) at E {sub C}-0.45 eV to 0.88x10{sup 13} (eV{sup -1} cm{sup 2}) at E {sub C}-0.66 eV.

  5. Vartotojų požiūrio formavimas reklamos priemonėmis: „Coca-Cola“ pavyzdžiu

    OpenAIRE

    Kučkovaitė, Agnė

    2018-01-01

    Šio darbo tikslas – ištirti Lietuvos gyventojų požiūrį į reklamą ir pateikti „Coca-Cola“ įmonei pasiūlymus kaip tinkamiausiu būdu reklamuoti savo paslaugas internete. Darbas sudarytas iš trijų dalių. Pirmoje dalyje teoriniu aspektu apibūdinama ir palyginama su kitomis reklamos priemonėmis reklama internete, jos privalumai, trūkumai ir perspektyvos. Antroje dalyje pristatoma „Coca-Cola“ įmonė, analizuojami Lietuvos gyventojų požiūrio į reklamą internete tyrimo rezultatai, nustatomi tinka...

  6. A Study on Clinical and Pathologic Features in Lupus Nephritis with Mainly IgA Deposits and a Literature Review

    Directory of Open Access Journals (Sweden)

    Liu Hongyan

    2013-01-01

    Full Text Available Objective. To study the clinical and pathologic features of systemic lupus erythematosus (SLE that has atypical lupus nephritis (LN with mainly IgA deposits. Methods. We searched the SLE patients who had nephritis with mainly IgA deposits in our hospital and selected the information including clinical manifestations, laboratory tests, treatments, and prognosis. Results. From January 2009 to June 2012, 5 patients were definitely diagnosed as SLE according to both 1982 and 2009 ACR classification criteria. But renal biopsy showed that all cases had mainly IgA deposits and were free of IgG, C1q, and fibrinogen-related antigen deposits under immunofluorescent microscopy, which did not match with typical LN. There were 2 males and 3 females, aging from 31 to 64 years and with an average of years. The 5 cases had multiple-system involvements, mainly the renal system. Compared to primary IgAN, the atypical LN showed some differences: older than primary IgAN, more women than men, no previous infection history, lower incidence of serum IgA elevation, and ACL positive rate as high as 100%. Conclusion. Nephritis with mainly IgAN deposits, as an atypical LN, may be a special subtype of SLE.

  7. In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia

    Directory of Open Access Journals (Sweden)

    Hernán Trimarchi

    2017-05-01

    Full Text Available Background: Podocyturia may determine the evolution to podocytopenia, glomerulosclerosis, and renal failure. According to the Oxford classification of IgA nephropathy (IgAN, the S1 lesion describes glomerulosclerosis. Urokinase-type plasminogen activator receptor (uPAR participates in podocyte attachment, while CD80 increases in glomerulosclerosis. We measured uPAR-positive urinary podocytes and urinary CD80 (uCD80 in controls and in IgAN subjects with M1E0S0T0 and M1E0S1T0 Oxford scores to assess a potential association between podocyturia, inflammation, and glomerulosclerosis. Methods: The groups were as follows: controls (G1, n = 20 and IgAN group (G2, n = 39, subdivided into M1E0S0T0 (G2A, n = 21 and M1E0S1T0 (G2B, n = 18. Among the included variables, we determined uPAR-positive podocytes/gram of urinary creatinine (gUrCr and uCD80 ng/gUrCr. Biopsies with interstitial fibrosis and tubular atrophy <10% were included. Results: Groups were not different in age and gender; urinary protein-creatinine (uP/C ratio, Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI equation, uPAR-positive podocytes/gUrCr, and uCD80 were significantly increased in G2 versus G1. G2A and G2B were not different in age, gender, hypertension, and follow-up. G2B displayed significantly higher uP/C, uPAR-positive podocytes, uCD80, and lower CKD-EPI versus G2A. Strong significant correlations were encountered between uCD80 and podocyturia in G2A and G2B. However, when G1 was compared to G2A and G2B separately, the differences with respect to uP/C, uPAR-positive podocytes, and podocyturia were significantly stronger versus G2B than versus G2A. Conclusions: IgAN presents elevated uCD80 excretion and uPAR-positive podocyturia, while CD80 correlates with podocyturia. Glomerulosclerosis (S1 at the time of biopsy is associated with higher uP/C, lower renal function, increased uPAR-positive podocyturia, and CD80 excretion, and is independent of M1. In IgAN, uPAR may

  8. IgA Nephropathy and Thrombotic Microangiopathy

    Directory of Open Access Journals (Sweden)

    Graciela De Rosa

    2017-06-01

    Full Text Available Introduction: Although the association between thrombotic microangiopathy (TMA and IgA nephropathy (IgAN is a known fact, its prevalence, pathogenesis and progression are not clear yet. Methods: A descriptive, retrospective study involving 12 patients with IgAN and TMA (IgAN-TMA was carried out; patients were diagnosed by a renal biopsy performed in our hospital in order to analyze clinicopathologic features. All the biopsy samples were processed for light microscopy and immunofluorescence. Results: The prevalence of patients with IgAN-TMA was 4.4% (12/274. The mean age was 33 and 58.3% of the subjects were men, showing, during diagnosis, mean systolic and diastolic blood pressure values of 171.3±53 mmHg and 97.5±19.8 mmHg, respectively. The average amount of protein in urine was 5.3 ± 3.7g/24 h and 8 patients had nephrotic- range proteinuria. Impairment of renal function was found in 11 patients, with a mean serum creatinine level of 7.2±4.7 mg/dL. No clinical or laboratory findings suggested thrombotic microangiopathy in any of the patients. The renal biopsy showed acute TMA with arteriolar fibrin thrombi in 75% of the subjects and ‘onion-skin-like’ chronic lesions with concentric intimal hyperplasia in 83.3% of them, which were associated with a high percentage of global glomerulosclerosis (72%, moderate tubular atrophy (38.6% and/or interstitial fibrosis (31.3%. In 91.7% of the cases, TMA was related to histological grade 5. Conclusions: The prevalence and significance of the relationship between IgAN and TMA pose the question of whether TMA is the cause or consequence of advanced stage IgAN. Several clinicopathologic studies have proved that TMA plays a major role in IgAN progression. The connection of TMA with creatinine serum and proteinuria levels seems to support this conclusion. While systemic TMA usually affects multiple organs, in these cases, the kidney was the only one compromised. Endothelial injury and the

  9. Electrical characteristics and interface properties of ALD-HfO2/AlGaN/GaN MIS-HEMTs fabricated with post-deposition annealing

    Science.gov (United States)

    Kubo, Toshiharu; Egawa, Takashi

    2017-12-01

    HfO2/AlGaN/GaN metal-insulator-semiconductor (MIS)-type high electron mobility transistors (HEMTs) on Si substrates were fabricated by atomic layer deposition of HfO2 layers and post-deposition annealing (PDA). The current-voltage characteristics of the MIS-HEMTs with as-deposited HfO2 layers showed a low gate leakage current (I g) despite the relatively low band gap of HfO2, and a dynamic threshold voltage shift (ΔV th) was observed. After PDA above 500 °C, ΔV th was reduced from 2.9 to 0.7 V with an increase in I g from 2.2 × 10-7 to 4.8 × 10-2 mA mm-1. Effects of the PDA on the HfO2 layer and the HfO2/AlGaN interface were investigated by x-ray photoelectron spectroscopy (XPS) using synchrotron radiation. XPS data showed that oxygen vacancies exist in the as-deposited HfO2 layers and they disappeared with an increase in the PDA temperature. These results indicate that the deep electron traps that cause ΔV th are related to the oxygen vacancies in the HfO2 layers.

  10. Synchronising EDML and NorthGRIP ice cores using d18O of atmospheric oxygen (d18 Oatm) and CH4 measurements over MIS5 (80-123 kyr)

    DEFF Research Database (Denmark)

    Capron, E; Landais, A; Lemieux-Dudon, B

    2010-01-01

    Water isotope records from the EPICA Dronning Maud Land (EDML) and the NorthGRIP ice cores have revealed a one to one coupling between Antarctic Isotope Maxima (AIM) and Greenland Dansgaard-Oeschger (DO) events back to 50 kyr. In order to explore if this north-south coupling is persistent over...... Marine Isotopic Stage 5 (MIS 5). a common timescale must first be constructed. Here, we present new records of delta O-18 of O-2 (delta O-18(atm)) and methane (CH4) measured in the air trapped in ice from the EDML (68-147 kyr) and NorthGRIP (70-123 kyr) ice cores. We demonstrate that, through the period...... of interest, CH4 records alone are not sufficient to construct a common gas timescale between the two cores. Millennial-scale variations of delta O-18(atm) are evidenced over MIS 5 both on the Antarctic and Greenland ice cores and are coupled to CH4 profiles to synchronise the NorthGRIP and EDML records...

  11. Temperature dependent electrical characterisation of Pt/HfO{sub 2}/n-GaN metal-insulator-semiconductor (MIS) Schottky diodes

    Energy Technology Data Exchange (ETDEWEB)

    Shetty, Arjun, E-mail: arjun@ece.iisc.ernet.in; Vinoy, K. J. [Electrical Communication Engineering, Indian Institute of Science, Bangalore, India 560012 (India); Roul, Basanta; Mukundan, Shruti; Mohan, Lokesh; Chandan, Greeshma; Krupanidhi, S. B. [Materials Research Centre, Indian Institute of Science, Bangalore, India 560012 (India)

    2015-09-15

    This paper reports an improvement in Pt/n-GaN metal-semiconductor (MS) Schottky diode characteristics by the introduction of a layer of HfO{sub 2} (5 nm) between the metal and semiconductor interface. The resulting Pt/HfO{sub 2}/n-GaN metal-insulator-semiconductor (MIS) Schottky diode showed an increase in rectification ratio from 35.9 to 98.9(@ 2V), increase in barrier height (0.52 eV to 0.63eV) and a reduction in ideality factor (2.1 to 1.3) as compared to the MS Schottky. Epitaxial n-type GaN films of thickness 300nm were grown using plasma assisted molecular beam epitaxy (PAMBE). The crystalline and optical qualities of the films were confirmed using high resolution X-ray diffraction and photoluminescence measurements. Metal-semiconductor (Pt/n-GaN) and metal-insulator-semiconductor (Pt/HfO{sub 2}/n-GaN) Schottky diodes were fabricated. To gain further understanding of the Pt/HfO{sub 2}/GaN interface, I-V characterisation was carried out on the MIS Schottky diode over a temperature range of 150 K to 370 K. The barrier height was found to increase (0.3 eV to 0.79 eV) and the ideality factor decreased (3.6 to 1.2) with increase in temperature from 150 K to 370 K. This temperature dependence was attributed to the inhomogeneous nature of the contact and the explanation was validated by fitting the experimental data into a Gaussian distribution of barrier heights.

  12. Observation of apparent MOS regimes on Al/PECVD grown boron nitride/p-c-Si/Al MIS structure, investigated through admittance spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Oezdemir, Orhan [Yildiz Technical University, Department of Physics, Esenler, istanbul (Turkey)

    2009-02-15

    PECVD grown boron nitride (BN) on crystalline silicon (c-Si) semiconductor was investigated by admittance measurement in the form of metal/insulator/semiconductor (MIS) structure. Apart from well-known regimes of traditional MOS structure, gradual bypassing of depletion layer was observed once ambient temperature (frequency) increased (decreased). Such an anomalous behavior was interpreted through modulations of charges located within BN film and/or at the interfacial layer of BN film/c-Si junction in terms of weighted average concept. (author)

  13. Effects of strength mis-matching on the fracture behavior of nuclear pressure steel A508-III welded joint

    Energy Technology Data Exchange (ETDEWEB)

    Zhu Zhengqiang [School of Material Science and Technology, Shanghai Jiaotong University, 1954 Huashan Road, Shanghai 200030 (China)]. E-mail: zhuzhq01@sjtu.edu.cn; Jing Hongyang [School of Material Science and Technology, Tianjin University, Tianjin 300072 (China); Ge Jingguo [School of Material Science and Technology, Shanghai Jiaotong University, 1954 Huashan Road, Shanghai 200030 (China); Chen Ligong [School of Material Science and Technology, Shanghai Jiaotong University, 1954 Huashan Road, Shanghai 200030 (China)

    2005-01-15

    In this paper, according to the nuclear pressure steel A508-III, the effect of strength mis-matching on the fracture behavior was analyzed by fracture mechanics test and the crack tip stress field of three-point bend specimen was analyzed by using finite element analysis method (FEM). The fracture of heat-affected zone (HAZ) was emphasized especially. The results of FEM show that if the under-matching weld was used, the opening stress and stress triaxiality in the vicinity of crack tip would increase for weld-crack specimen, and would reduce for HAZ-crack specimen. This tendency was confirmed by the test results.

  14. Mis-Match Limit Load Analyses and Fracture Mechanics Assessment for Welded Pipe with Circumferential Crack at the Center of Weldment

    Energy Technology Data Exchange (ETDEWEB)

    Song, Tae Kwang; Jeon, Jun Young; Shim, Kwang Bo; Kim, Yun Jae [Korea University, Seoul (Korea, Republic of); Kim, Jong Sung [Sunchon University, Suncheon (Korea, Republic of); Jin, Tae Eun [Korea Power Engineering Company, Daejeon (Korea, Republic of)

    2010-01-15

    In this paper, limit load analyses and fracture mechanics analyses were conducted via finite element analyses for the welded pipe with circumferential crack at the center of the weldment. Systematic changes for strength mismatch ratio, width of weldment, crack shape and thickness ratio of the pipe were considered to provide strength mismatch limit load. And J-integral calculations based on reference stress method were conducted for two materials, stainless steel and ferritic steel. Reference stress defined by provided strength mis-match limit load gives much more accurate J-integral.

  15. Civacuve analysis software for mis machine examination of pressurized water reactor vessels

    International Nuclear Information System (INIS)

    Dubois, Ph.; Gagnor, A.

    2001-01-01

    The product software CIVACUVE is used by INTERCONTROLE for the analysis of UT examinations, for detection, performed by the In-Service Inspection Machine (MIS) of the vessels of nuclear power plants. This software is based on an adaptation of an algorithm of SEGMENTATION (CEA CEREM), which is applied prior to any analysis. It is equipped with tools adapted to industrial use. It allows to: - perform image analysis thanks to advanced graphic tools (Zooms, True Bscan, 'contour' selection...), - backup of all data in a database (complete and transparent backup of all informations used and obtained during the different analysis operations), - connect PC to the Database (export of Reports and even of segmented points), - issue Examination Reports, Operating Condition Sheets, Sizing curves... - and last, perform a graphic and numerical comparison between different inspections of the same vessel. Used in Belgium and France on different kind of reactor vessels, CIVACUVE has allowed to show that the principle of SEGMENTATION can be adapted to detection exams. The use of CIVACUVE generates a important time gain as well as the betterment of quality in analysis. Wide data opening toward PC's allows a real flexibility with regard to client's requirements and preoccupations

  16. Characterization of a SiC MIS Schottky diode as RBS particle detector

    Science.gov (United States)

    Kaufmann, I. R.; Pick, A. C.; Pereira, M. B.; Boudinov, H. I.

    2018-02-01

    A 4H-SiC Schottky diode was investigated as a particle detector for Rutherford Backscattering Spectroscopy (RBS) experiment. The device was fabricated on a commercial 4H-SiC epitaxial n-type layer grown onto a 4H-SiC n+ type substrate wafer doped with nitrogen. Hafnium oxide with thickness of 1 nm was deposited by Atomic Layer Deposition and 10 nm of Ni were deposited by sputtering to form the Ni/HfO2/4H-SiC MIS Schottky structure. Current-Voltage curves with variable temperature were measured to extract the real Schottky Barrier Height (0.32 V) and ideality factor values (1.15). Reverse current and Capacitance-Voltage measurements were performed on the 4H-SiC detector and compared to a commercial Si barrier detector acquired from ORTEC. RBS data for four alpha energies (1, 1.5, 2 and 2.5 MeV) were collected from an Au/Si sample using the fabricated SiC and the commercial Si detectors simultaneously. The energy resolution for the fabricated detector was estimated to be between 75 and 80 keV.

  17. On the profile of frequency and voltage dependent interface states and series resistance in MIS structures

    Energy Technology Data Exchange (ETDEWEB)

    Doekme, Ilbilge [Science Education Department, Faculty of Kirsehir Education, Gazi University, Kirsehir (Turkey)]. E-mail: ilbilgedokme@gazi.edu.tr; Altindal, Semsettin [Physics Department, Faculty of Arts and Sciences, Gazi University, 06500, Teknikokullar, Ankara (Turkey)

    2007-04-30

    The variation in the capacitance-voltage (C-V) and conductance-voltage (G/{omega}-V) characteristics of Au/SiO{sub 2}/n-Si metal-insulator-semiconductor (MIS) structure have been systematically investigated as a function of frequencies in the frequency range 0.5 kHz-10 MHz at room temperature. In addition, the forward and reverse bias current-voltage (I-V) characteristics of this structure were measured at room temperature. The high value of ideality factor was attributed to the high density of interface states localized at Si/SiO{sub 2} interface and interfacial oxide layer. The density of interface states (N{sub ss}) and the series resistance (R{sub ss}) were calculated from I-V and C-V measurements using different methods and the effect of them on C-V and G/{omega}-V characteristics were deeply researched. At the same energy position near the top of valance band, the calculated N{sub ss} values, obtained without taking into account the series resistance of the devices almost one order of magnitude larger than N{sub ss} values obtained by taking into account R{sub ss} values. It is found that the C-V and G/{omega}-V curves exhibit a peak at low frequencies and the peak values of C and G/{omega} decrease with increasing frequency. Also, the plots of R {sub s} as a function of bias give two peaks in the certain voltage range at low frequencies. These observations indicate that at low frequencies, the charges at interface states can easily follow an AC signal and the number of them increases with decreasing frequency. The I-V, C-V and G/{omega}-V characteristics of the MIS structure are affected not only with R {sub s} but also N {sub ss}. Experimental results show that both the R{sub s} and C{sub o} values should be taken into account in determining frequency-dependent electrical characteristics.

  18. Association of proteinuria with various clinical findings and morphologic variables of oxford classification in immunoglobulin a nephropathy patients

    Directory of Open Access Journals (Sweden)

    Hamid Nasri

    2013-01-01

    Conclusions: Our findings firstly support the prognostic value of crescent due to its association with proteinuria and secondly imply the importance of treatment of proteinuria to prevent progression of IgAN.

  19. A retrospective observational study of glucocorticoid-induced diabetes mellitus with IgA nephropathy treated with tonsillectomy plus methylprednisolone pulse therapy.

    Directory of Open Access Journals (Sweden)

    Yoshia Miyawaki

    Full Text Available To evaluate the incidence of GC-DM among patients with immunoglobulin A nephropathy (IgAN and to confirm the risk factors for the development of GC-DM.The medical records of patients with IgAN newly treated with the protocol of tonsillectomy combined with steroid pulse therapy were reviewed. The primary outcome was the development of GC-DM within the hospitalization period and during one year of follow-up.During hospitalization, 19 of the 95 patients developed GC-DM (20.0%, and the patients with GC-DM were significantly older and had a higher rate of family history of diabetes and higher HbA1c levels. The prevalence of hypertension was higher and the eGFR was numerically lower in patients with GC-DM than in those without. Older age (≥45 years and a family history of diabetes emerged as independent risk factors for the development of GC-DM (odds ratio [OR], 6.3 and 95% confidence interval [CI], 1.6-27.6; OR, 4.4 and 95% CI, 1.2-16.6, respectively. No patients were newly diagnosed with GC-DM during 1-year observation period at out-patient clinic.Among the patients with IgAN, 20% developed GC-DM during the hospitalization period, confirming the family history of diabetes is clinically necessary before starting GC therapy.

  20. CagA, a major virulence factor of Helicobacter pylori, promotes the production and underglycosylation of IgA1 in DAKIKI cells

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Man [Department of Nephrology, The First Affiliated Hospital of Chengdu Medical College, Chengdu City 610500 (China); Li, Fu-gang [Department of Nephrology, Affiliated Hospital of Luzhou Medical College, Luzhou City 646000 (China); Xie, Xi-sheng [Department of Nephrology, Second Clinical Medical Institution of North Sichuan Medical College (Nanchong Central Hospital), Nanchong City 637400 (China); Wang, Shao-qing [Department of Nephrology, The First Affiliated Hospital of Chengdu Medical College, Chengdu City 610500 (China); Fan, Jun-ming, E-mail: junmingfan@163.com [Department of Nephrology, The First Affiliated Hospital of Chengdu Medical College, Chengdu City 610500 (China); Department of Nephrology, Affiliated Hospital of Luzhou Medical College, Luzhou City 646000 (China)

    2014-02-07

    Highlights: • CagA stimulated cell proliferation and the production of IgA1 in DAKIKI cells. • CagA promoted the underglycosylation of IgA1 in DAKIKI cells. • CagA decreased the expression of C1GALT1 and its chaperone Cosmc in DAKIKI cells. • Helicobacter pylori infection may participate in the pathogenesis of IgAN via CagA. - Abstract: While Helicobacter pylori (Hp) infection is closely associated with IgA nephropathy (IgAN), the underlying molecular mechanisms remain to be elucidated. This study was to investigate the effect of cytotoxin associated gene A protein (CagA), a major virulence factor of Hp, on the production and underglycosylation of IgA1 in the B cell line DAKIKI cells. Cells were cultured and treated with recombinant CagA protein. We found that CagA stimulated cell proliferation and the production of IgA1 in a dose-dependent and time-dependent manner. Moreover, CagA promoted the underglycosylation of IgA1, which at least partly attributed to the downregulation of β1,3-galactosyltransferase (C1GALT1) and its chaperone Cosmc. In conclusion, we demonstrated that Hp infection, at least via CagA, may participate in the pathogenesis of IgAN by influencing the production and glycosylation of IgA1 in B cells.

  1. A retrospective observational study of glucocorticoid-induced diabetes mellitus with IgA nephropathy treated with tonsillectomy plus methylprednisolone pulse therapy

    Science.gov (United States)

    Katsuyama, Takayuki; Sada, Ken-Ei; Hiramatsu, Sumie; Ohashi, Keiji; Morishita, Michiko; Katsuyama, Eri; Watanabe, Haruki; Takano-Narazaki, Mariko; Toyota-Tatebe, Noriko; Sunahori-Watanabe, Katsue; Kawabata, Tomoko; Inoue, Tatsuyuki; Kinomura, Masaru; Sugiyama, Hitoshi; Wada, Jun

    2017-01-01

    Aims To evaluate the incidence of GC-DM among patients with immunoglobulin A nephropathy (IgAN) and to confirm the risk factors for the development of GC-DM. Methods The medical records of patients with IgAN newly treated with the protocol of tonsillectomy combined with steroid pulse therapy were reviewed. The primary outcome was the development of GC-DM within the hospitalization period and during one year of follow-up. Results During hospitalization, 19 of the 95 patients developed GC-DM (20.0%), and the patients with GC-DM were significantly older and had a higher rate of family history of diabetes and higher HbA1c levels. The prevalence of hypertension was higher and the eGFR was numerically lower in patients with GC-DM than in those without. Older age (≥45 years) and a family history of diabetes emerged as independent risk factors for the development of GC-DM (odds ratio [OR], 6.3 and 95% confidence interval [CI], 1.6–27.6; OR, 4.4 and 95% CI, 1.2–16.6, respectively). No patients were newly diagnosed with GC-DM during 1-year observation period at out-patient clinic. Conclusions Among the patients with IgAN, 20% developed GC-DM during the hospitalization period, confirming the family history of diabetes is clinically necessary before starting GC therapy. PMID:28562629

  2. Defect analysis in GaN films of HEMT structure by cross-sectional cathodoluminescence

    Science.gov (United States)

    Isobe, Yasuhiro; Hung, Hung; Oasa, Kohei; Ono, Tasuku; Onizawa, Takashi; Yoshioka, Akira; Takada, Yoshiharu; Saito, Yasunobu; Sugiyama, Naoharu; Tsuda, Kunio; Sugiyama, Toru; Mizushima, Ichiro

    2017-06-01

    Defect analysis of GaN films in high electron mobility transistor (HEMT) structures by cross-sectional cathodoluminescence (X-CL) is demonstrated as a useful technique for improving the current collapse of GaN-HEMT devices, and the relationship between crystal quality and device characteristics is also investigated. The crystal quality of intrinsic-GaN (i-GaN) and carbon-doped GaN produced clearly different peak intensities of blue luminescence (BL), yellow luminescence (YL), and band-edge emission (BE), which is independently detected by X-CL. Current collapse in GaN-HEMT devices is found to be determined by the BL/BE and YL/BE ratios at the top of the i-GaN layer, which is close to the channel. Moreover, the i-GaN thickness required in order to minimize the BL/BE and YL/BE ratios and the thickness dependency of GaN for minimizing the BL/BE and YL/BE ratios depending on the growth conditions can be evaluated by X-CL. However, there is no correlation between current collapse in GaN-HEMT devices and the YL/BE ratio by conventional photoluminescence because HEMT devices consist of multiple GaN layers and the YL signal is detected from the carbon-doped GaN layer. Thus, the X-CL analysis method is a useful technique for device design in order to suppress current collapse.

  3. CagA, a major virulence factor of Helicobacter pylori, promotes the production and underglycosylation of IgA1 in DAKIKI cells

    International Nuclear Information System (INIS)

    Yang, Man; Li, Fu-gang; Xie, Xi-sheng; Wang, Shao-qing; Fan, Jun-ming

    2014-01-01

    Highlights: • CagA stimulated cell proliferation and the production of IgA1 in DAKIKI cells. • CagA promoted the underglycosylation of IgA1 in DAKIKI cells. • CagA decreased the expression of C1GALT1 and its chaperone Cosmc in DAKIKI cells. • Helicobacter pylori infection may participate in the pathogenesis of IgAN via CagA. - Abstract: While Helicobacter pylori (Hp) infection is closely associated with IgA nephropathy (IgAN), the underlying molecular mechanisms remain to be elucidated. This study was to investigate the effect of cytotoxin associated gene A protein (CagA), a major virulence factor of Hp, on the production and underglycosylation of IgA1 in the B cell line DAKIKI cells. Cells were cultured and treated with recombinant CagA protein. We found that CagA stimulated cell proliferation and the production of IgA1 in a dose-dependent and time-dependent manner. Moreover, CagA promoted the underglycosylation of IgA1, which at least partly attributed to the downregulation of β1,3-galactosyltransferase (C1GALT1) and its chaperone Cosmc. In conclusion, we demonstrated that Hp infection, at least via CagA, may participate in the pathogenesis of IgAN by influencing the production and glycosylation of IgA1 in B cells

  4. Prosa y verso en Umbral: entre la dispersión y el cancionero de Mis paraísos artificiales

    Directory of Open Access Journals (Sweden)

    Díez, J. Ignacio

    2015-08-01

    Full Text Available In contrast with the whole classical tradition that abhors the mixture of prose and verse, Umbral mixes poems (sometimes in verse and sometimes in prose in his work. Umbral filled his literary path with fragments of poetry showing him to be a genuine poet; these pieces also serve to compensate for his giving up poetry for more productive pursuits and to compose a sort of giant songbook that, significantly, he never wanted to compile. In Mis paraísos artificiales the technique is quantitatively and qualitatively different: to organise a single songbook that alternates prose and verse in the old Renaissance style, although Umbral prefers to tie in with with Juan Ramón Jiménez. This technique is used in Mortal y rosa, to a lesser extent and with other features.Frente a toda la tradición clásica que aborrece la mezcla de prosa y verso, Umbral entrevera los poemas (en verso a veces y también en prosa dentro de su obra. Llena Umbral su camino literario con piezas poéticas que demuestren que es poeta, que suplan su abandono de la poesía por más productivas dedicaciones y que compongan una suerte de gigantesco cancionero que, muy significativamente, nunca quiso reunir. En Mis paraísos artificiales el recurso es cuantitativa y cualitativamente distinto: componer un cancionero único que alterne prosa y verso al viejo estilo renacentista, aunque Umbral prefiere entroncar con Juan Ramón Jiménez. El recurso también se utiliza en Mortal y rosa, en menor medida y con otras funciones.

  5. Kidney Transplant Recipients With Primary Membranous Glomerulonephritis Have a Higher Risk of Acute Rejection Compared With Other Primary Glomerulonephritides

    Directory of Open Access Journals (Sweden)

    Tripti Singh, MD

    2017-11-01

    Conclusions. Patients with MN have higher incidence of acute rejection after kidney transplant but have similar 10-year allograft survival in comparison to the other glomerular diseases like IgAN, FSGS, and LN.

  6. Distribution of Biopsy-Proven Presumed Primary Glomerulonephropathies in 2000-2011 Among a Racially and Ethnically Diverse US Population.

    Science.gov (United States)

    Sim, John J; Batech, Michael; Hever, Aviv; Harrison, Teresa N; Avelar, Taurino; Kanter, Michael H; Jacobsen, Steven J

    2016-10-01

    The incidence and distribution of primary glomerulonephropathies vary throughout the world and by race and ethnicity. We sought to evaluate the distribution of primary glomerulonephropathies among a large racially and ethnically diverse population of the United States. Case series from January 1, 2000, through December 31, 2011. Adults (aged ≥ 18 years) of an integrated health system who underwent native kidney biopsy and had kidney biopsy findings demonstrating focal segmental glomerulosclerosis (FSGS), membranous glomerulonephritis (MGN), minimal change disease (MCD), immunoglobulin A nephropathy (IgAN), and other. Rates and characteristics of the most common primary glomerulonephropathies overall and by race and ethnicity. 2,501 patients with primary glomerulonephropathy were identified, with a mean age 50.6 years, 45.7% women, 36.1% Hispanics, 31.2% non-Hispanic whites, 17.4% blacks, and 12.4% Asians. FSGS was the most common glomerulonephropathy (38.9%) across all race and ethnic groups, followed by MGN (12.7%), MCD (11.0%), IgAN (10.2%), and other (27.3%). The FSGS category had the greatest proportion of blacks, and patients with FSGS had the highest rate of poverty. IgAN was the second most common glomerulonephropathy among Asians (28.6%), whereas it was 1.2% among blacks. Patients with MGN presented with the highest proteinuria (protein excretion, 8.3g) whereas patients with FSGS had the highest creatinine levels (2.6mg/dL). Overall glomerulonephropathy rates increased annually in our 12-year observation period, driven by FSGS (2.7 cases/100,000) and IgAN (0.7 cases/100,000). MGN and MCD rates remained flat. Missing data for urine albumin and sediment, indication bias in performing kidney biopsies, and inexact classification of primary versus secondary disease. Among a racially and ethnically diverse cohort from a single geographical area and similar environment, FSGS was the most common glomerulonephropathy, but there was variability of other

  7. A high-resolution Early Holocene-late MIS 3 environmental rock- and palaeomagnetic record from Lake Sf. Ana, Carpathian Mts, Romania

    Directory of Open Access Journals (Sweden)

    Daniel VERES

    2014-11-01

    Full Text Available Lacustrine sediments are excellent sources of palaeoenvironmental and palaeoclimatic information because they usually provide continuous and high-resolution records. In centraleastern Europe however lacustrine records that extend beyond the Holocene are rather sparse.Palaeomagnetic records from this region are also insufficiently explored, and usually associated with terrestrial deposits such as loess. In this context, the lacustrine record of Lake Sf. Ana, a volcanic crater lake in the East Carpathians, Romania, provides an important archive for reconstructing past paleomagnetic secular variation in the region from early Holocene to late Marine Isotope Stage (MIS 3.

  8. Association of Habitual Patterns and Types of Physical Activity and Inactivity with MRI-Determined Total Volumes of Visceral and Subcutaneous Abdominal Adipose Tissue in a General White Population.

    Directory of Open Access Journals (Sweden)

    Karina Fischer

    Full Text Available Population-based evidence for the role of habitual physical activity (PA in the accumulation of visceral (VAT and subcutaneous (SAAT abdominal adipose tissue is limited. We investigated if usual patterns and types of self-reported PA and inactivity were associated with VAT and SAAT in a general white population. Total volumes of VAT and SAAT were quantified by magnetic resonance imaging in 583 men and women (61 ± 11.9 y; BMI 27.2 ± 4.4 kg/m2. Past-year PA and inactivity were self-reported by questionnaire. Exploratory activity patterns (APAT were derived by principal components analysis. Cross-sectional associations between individual activities, total PA in terms of metabolic equivalents (PA MET, or overall APAT and either VAT or SAAT were analyzed by multivariable-adjusted robust or generalized linear regression models. Whereas vigorous-intensity PA (VPA was negatively associated with both VAT and SAAT, associations between total PA MET, moderate-intensity PA (MPA, or inactivity and VAT and/or SAAT depended on sex. There was also evidence of a threshold effect in some of these relationships. Total PA MET was more strongly associated with VAT in men (B = -3.3 ± 1.4; P = 0.02 than women (B = -2.1 ± 1.1; P = 0.07, but was more strongly associated with SAAT in women (B = -5.7 ± 2.5; P = 0.05 than men (B = -1.7 ± 1.6; P = 0.3. Men (-1.52 dm3 or -1.89 dm3 and women (-1.15 dm3 or -2.61 dm3 in the highest (>6.8 h/wk VPA or second (4.0-6.8 h/wk VPA tertile of an APAT rich in VPA, had lower VAT and SAAT, respectively, than those in the lowest (<4.0 h/wk VPA tertile (P ≤ 0.016; P trend ≤ 0.0005. They also had lower VAT and SAAT than those with APAT rich in MPA and/or inactivity only. In conclusion, our results suggest that in white populations, habitual APAT rich in MPA might be insufficient to impact on accumulation of VAT or SAAT. APAT including ≥ 4.0-6.8 h/wk VPA, by contrast, are more strongly associated with lower VAT and SAAT.

  9. On the energy distribution profile of interface states obtained by taking into account of series resistance in Al/TiO2/p-Si (MIS) structures

    International Nuclear Information System (INIS)

    Pakma, O.; Serin, N.; Serin, T.; Altindal, S.

    2011-01-01

    The energy distribution profile of the interface states (N ss ) of Al/TiO 2 /p-Si (MIS) structures prepared using the sol-gel method was obtained from the forward bias current-voltage (I-V) characteristics by taking into account both the bias dependence of the effective barrier height (φ e ) and series resistance (R s ) at room temperature. The main electrical parameters of the MIS structure such as ideality factor (n), zero-bias barrier height (φ b0 ) and average series resistance values were found to be 1.69, 0.519 eV and 659 Ω, respectively. This high value of n was attributed to the presence of an interfacial insulator layer at the Al/p-Si interface and the density of interface states (N ss ) localized at the Si/TiO 2 interface. The values of N ss localized at the Si/TiO 2 interface were found with and without the R s at 0.25-E v in the range between 8.4x10 13 and 4.9x10 13 eV -1 cm -2 . In addition, the frequency dependence of capacitance-voltage (C-V) and conductance-voltage (G/ω-V) characteristics of the structures have been investigated by taking into account the effect of N ss and R s at room temperature. It can be found out that the measured C and G/ω are strongly dependent on bias voltage and frequency. -- Research highlights: →We successfully fabricated Al/TiO 2 /p-Si device with interlayer by a sol-gel method. The facts: (i) that the technology of the fabrication of a Al/TiO 2 /p-Si MIS structure much simpler and economical than that for the Si p-n junction and (b) the main advantages of TiO 2 films are low densities of the surface states when compared to SiO 2 .

  10. Improvement on the electrical characteristics of Pd/HfO{sub 2}/6H-SiC MIS capacitors using post deposition annealing and post metallization annealing

    Energy Technology Data Exchange (ETDEWEB)

    Esakky, Papanasam, E-mail: papanasamte@gmail.com; Kailath, Binsu J

    2017-08-15

    Highlights: • Post deposition annealing (PDA) and post metallization annealing (PMA) on the electrical characteristics of Pd/HfO{sub 2}/6H-SiC MIS capacitors. • Post deposition N{sub 2}O plasma annealing inhibits crystallization of HfO{sub 2} during high temperature annealing. • Plasma annealing followed by RTA in N{sub 2} results in formation of hafnium silicate at the HfO{sub 2}-SiC interface. • PDA reduces interface state density (D{sub it}) and gate leakage current density (J{sub g}) by order. • PMA in forming gas for 40 min results in better passivation and reduces D{sub it} by two orders and J{sub g} by thrice. - Abstract: HfO{sub 2} as a gate dielectric enables high electric field operation of SiC MIS structure and as gas sensor HfO{sub 2}/SiC capacitors offer higher sensitivity than SiO{sub 2}/SiC capacitors. The issue of higher density of oxygen vacancies and associated higher leakage current necessitates better passivation of HfO{sub 2}/SiC interface. Effect of post deposition annealing in N{sub 2}O plasma and post metallization annealing in forming gas on the structural and electrical characteristics of Pd/HfO{sub 2}/SiC MIS capacitors are reported in this work. N{sub 2}O plasma annealing suppresses crystallization during high temperature annealing thereby improving the thermal stability and plasma annealing followed by rapid thermal annealing in N{sub 2} result in formation of Hf silicate at the HfO{sub 2}/SiC interface resulting in order of magnitude lower density of interface states and gate leakage current. Post metallization annealing in forming gas for 40 min reduces interface state density by two orders while gate leakage current density is reduced by thrice. Post deposition annealing in N{sub 2}O plasma and post metallization annealing in forming gas are observed to be effective passivation techniques improving the electrical characteristics of HfO{sub 2}/SiC capacitors.

  11. Improvement on the electrical characteristics of Pd/HfO2/6H-SiC MIS capacitors using post deposition annealing and post metallization annealing

    Science.gov (United States)

    Esakky, Papanasam; Kailath, Binsu J.

    2017-08-01

    HfO2 as a gate dielectric enables high electric field operation of SiC MIS structure and as gas sensor HfO2/SiC capacitors offer higher sensitivity than SiO2/SiC capacitors. The issue of higher density of oxygen vacancies and associated higher leakage current necessitates better passivation of HfO2/SiC interface. Effect of post deposition annealing in N2O plasma and post metallization annealing in forming gas on the structural and electrical characteristics of Pd/HfO2/SiC MIS capacitors are reported in this work. N2O plasma annealing suppresses crystallization during high temperature annealing thereby improving the thermal stability and plasma annealing followed by rapid thermal annealing in N2 result in formation of Hf silicate at the HfO2/SiC interface resulting in order of magnitude lower density of interface states and gate leakage current. Post metallization annealing in forming gas for 40 min reduces interface state density by two orders while gate leakage current density is reduced by thrice. Post deposition annealing in N2O plasma and post metallization annealing in forming gas are observed to be effective passivation techniques improving the electrical characteristics of HfO2/SiC capacitors.

  12. Riparian landscapes and human habitat preferences during the Hoxnian (MIS 11) Interglacial

    Science.gov (United States)

    Ashton, Nick; Lewis, Simon G.; Parfitt, Simon; White, Mark

    2006-07-01

    The archaeological, environmental and geological data from Hoxnian Interglacial (Marine Isotope Stage (MIS) 11) sites from Britain are examined to elucidate the type of habitats that humans preferred during this temperate episode. The conclusion is that humans avoided lacustrine situations, but did make use of the full range of resources that fluvial environments provide. This model is strengthened by the examination of other non-archaeological Hoxnian sites. The problem of archaeological visibility in lacustrine sediment sequences is also discussed and methods of identifying other evidence of human presence are suggested that may offset the deficiencies in the lithic record. These include presence of cut-marked bone, micro-debitage and possibly charcoal in fine-grained sediments deposited in distal settings. The reasons for human selection of fluvial situations are discussed. It is concluded that these environments provide a greater diversity of animal, plant and lithic resources, but also are major route-ways through the landscape. Patterns of human site use are identified, which seem to be triggered by local changes in hydrology and drainage, themselves possibly caused by regional changes in climate. Finally, Lower Palaeolithic sites on the interfluves are discussed. Although they lack environmental or dating evidence, it is tentatively suggested that they were used during cooler episodes, when more open conditions prevailed. Copyright

  13. Pembuatan Alur Pelayaran dalam Rencana Pelabuhan Marina Pantai Boom, Banyuwangi

    Directory of Open Access Journals (Sweden)

    Muhammad Didi Darmawan

    2017-01-01

    Full Text Available Pantai Boom merupakan pantai yang ada di Kabupaten Banyuwangi. Pantai ini terletak di Kelurahan Kampung Mandar, Kecamatan Banyuwangi, Banyuwangi, Jawa Timur. Pantai tersebut rencananya akan dibangun pelabuhan marina. Pelabuhan harus dilengkapi dengan beberapa fasilitas untuk mendukung rencana tersebut seperti salah satunya adalah alur pelayaran. Untuk membuat alur pelayaran diperlukan penelitian mengenai pasang surut, topografi dasar laut, serta jenis kapal yang melintas untuk memastikan kapal yang berlayar aman dari kemungkinan kecelakaan. Penelitian ini menggunakan data hasil pemeruman, data pasang surut yang diperoleh dari pengamatan langsung, serta berbagai jenis kapal yacht. Hasil dari penelitian ini didapatkan bahwa rencana dermaga sebaiknya dibangun 60 meter menjorok ke arah laut dengan panjang dermaga 25 meter. Dalam keadaan air rendah terendah (LLWL, ketiga jenis kapal yang ditentukan dapat merapat ke rencana Dermaga Pelabuhan Marina Pantai Boom, Banyuwangi. Daerah yang tidak bisa dilewati pada saat LLWL, pada saat MSL daerah tersebut sudah dapat dilewati oleh ketiga jenis kapal tersebut. Pada keadaan muka air tinggi tertinggi (HHWL, Kapal Yacht Class 8 dan 6 dapat melewati sebagian perairan sungai Pantai Boom.         Waktu yang tidak tepat untuk melakukan pelayaran pada saat LLWL dari alur pelayaran yang telah dibuat yaitu antara pukul 04:00 – 06:00 WIB pada saat bulan November 2015-Februari 2016 dan pukul 16:00-18:00 pada saat bulan Juni-Agustus 2016. Sedangkan Waktu yang tepat untuk melakukan pelayaran pada saat HHWL yaitu antara pukul 20:00–23:00 WIB pada saat bulan Desember 2015- Maret 2016 dan pukul 8:00-11:00 pada saat bulan Juni-September 2016.

  14. Silicon based light emitter utilizing tunnel injection of excess carriers via MIS structure

    Energy Technology Data Exchange (ETDEWEB)

    Arguirov, Tzanimir; Kittler, Martin [IHP - Innovations for High Performance Microelectronics, Im Technologiepark 25, 15236 Frankfurt (Oder) (Germany); IHP/BTU Joint Lab BTU Cottbus, Konrad-Wachsmann-Allee 1, 03013 Cottbus (Germany); Wenger, Christian; Lukosius, Mindaugas [IHP - Innovations for High Performance Microelectronics, Im Technologiepark 25, 15236 Frankfurt (Oder) (Germany); Mchedlidze, Teimuraz [IHP/BTU Joint Lab BTU Cottbus, Konrad-Wachsmann-Allee 1, 03013 Cottbus (Germany); Reiche, Manfred [Max-Planck-Institut fuer Mikrostrukturphysik, Weinberg 2, 06120 Halle (Germany)

    2011-04-15

    We report on electro-luminescence from metal-insulator-semiconductor diodes (MISLED). MISLEDs prepared on silicon with HfO2 layers of different thicknesses were investigated and their properties compared with such prepared by using SiO2 insulator layer. The role of the insulator layer was studied in view of the efficiency of the band-to-band radiation from silicon. We show that the luminescence efficiency depends on the dielectric constant of the insulator as well as on its ability to conduct carriers by tunnelling. Efficiency enhancement of 3.3 times was detected when the SiO{sub 2} insulator was substituted by HfO{sub 2} in the MIS emitter. Optimal injection current exists, which leads to a maximal efficiency of the luminescence. The optimal current depends strongly on the thickness of the oxide. We relate the existence of an optimal current with the depth at which the injected minority carriers recombine radiatively. Thus the electric field in the semiconductor and the surface recombination are the factors determining the optimal injection (copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  15. A review of Early Weichselian climate (MIS 5d-a) in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Wohlfarth, Barbara [Dept. of Geological Sciences, Stockholm Univ., Stockholm (Sweden)

    2013-06-15

    additional feedbacks. The end of the last interglacial, i.e. the Eemian or MIS5e, and the transition into the last glacial period was initially triggered by a decrease in incoming summer insolation at high northern latitudes. The change in orbital configuration subsequently led to a series of time-transgressive changes (e.g. gradual vegetation replacement; changes in sea surface temperature, salinity, strength of the North Atlantic Current). As Northern Hemisphere ice sheets started to grow and expand these changes became more and more pronounced. The sequence of events leading from the last interglacial into the last glacial has been described using climate models with different complexity and boundary conditions, paleodata series, and comparisons between model out put and paleo data. One possible scenario involves the development of summer sea ice in the northern North Atlantic already during the later part of the Eemian interglacial, as a response to decreasing summer insolation. This would have accelerated a vegetation shift, which in turn would have led to a decrease in albedo. More extensive sea ice could, through brine formation, have increased the Atlantic meridional overturning circulation, which would have supplied more moisture to the cold high northern latitudes. This in turn would have favoured the growth of ice sheets. A response of the vegetation in northern Europe to the decrease in summer insolation and to increased summer sea ice may be seen as early as 122-120 thousand years (ka) ago, but became most distinct around 115 ka, when North Atlantic sea surface temperatures show signs of a first minor cooling. This cold event (labelled sea surface cooling event C26) defines the Marine Isotope Stage (MIS) 5e/5d transition in marine cores and seems to correlate with Greenland stadial GS26. This first distinct cooling event on Greenland is paralleled by cold temperatures in Antarctica, which implies synchronous cooling in both hemispheres. However, while Antarctica

  16. A review of Early Weichselian climate (MIS 5d-a) in Europe

    International Nuclear Information System (INIS)

    Wohlfarth, Barbara

    2013-06-01

    additional feedbacks. The end of the last interglacial, i.e. the Eemian or MIS5e, and the transition into the last glacial period was initially triggered by a decrease in incoming summer insolation at high northern latitudes. The change in orbital configuration subsequently led to a series of time-transgressive changes (e.g. gradual vegetation replacement; changes in sea surface temperature, salinity, strength of the North Atlantic Current). As Northern Hemisphere ice sheets started to grow and expand these changes became more and more pronounced. The sequence of events leading from the last interglacial into the last glacial has been described using climate models with different complexity and boundary conditions, paleodata series, and comparisons between model out put and paleo data. One possible scenario involves the development of summer sea ice in the northern North Atlantic already during the later part of the Eemian interglacial, as a response to decreasing summer insolation. This would have accelerated a vegetation shift, which in turn would have led to a decrease in albedo. More extensive sea ice could, through brine formation, have increased the Atlantic meridional overturning circulation, which would have supplied more moisture to the cold high northern latitudes. This in turn would have favoured the growth of ice sheets. A response of the vegetation in northern Europe to the decrease in summer insolation and to increased summer sea ice may be seen as early as 122-120 thousand years (ka) ago, but became most distinct around 115 ka, when North Atlantic sea surface temperatures show signs of a first minor cooling. This cold event (labelled sea surface cooling event C26) defines the Marine Isotope Stage (MIS) 5e/5d transition in marine cores and seems to correlate with Greenland stadial GS26. This first distinct cooling event on Greenland is paralleled by cold temperatures in Antarctica, which implies synchronous cooling in both hemispheres. However, while Antarctica

  17. Palaeoclimate characteristics in interior Siberia of MIS 6-2: first insights from the Batagay permafrost mega-thaw slump in the Yana Highlands

    Science.gov (United States)

    Ashastina, Kseniia; Schirrmeister, Lutz; Fuchs, Margret; Kienast, Frank

    2017-07-01

    Syngenetic permafrost deposits formed extensively on and around the arising Beringian subcontinent during the Late Pleistocene sea level lowstands. Syngenetic deposition implies that all material, both mineral and organic, freezes parallel to sedimentation and remains frozen until degradation of the permafrost. Permafrost is therefore a unique archive of Late Pleistocene palaeoclimate. Most studied permafrost outcrops are situated in the coastal lowlands of northeastern Siberia; inland sections are, however, scarcely available. Here, we describe the stratigraphical, cryolithological, and geochronological characteristics of a permafrost sequence near Batagay in the Siberian Yana Highlands, the interior of the Sakha Republic (Yakutia), Russia, with focus on the Late Pleistocene Yedoma ice complex (YIC). The recently formed Batagay mega-thaw slump exposes permafrost deposits to a depth of up to 80 m and gives insight into a climate record close to Verkhoyansk, which has the most severe continental climate in the Northern Hemisphere. Geochronological dating (optically stimulated luminescence, OSL, and 14C ages) and stratigraphic implications delivered a temporal frame from the Middle Pleistocene to the Holocene for our sedimentological interpretations and also revealed interruptions in the deposition. The sequence of lithological units indicates a succession of several distinct climate phases: a Middle Pleistocene ice complex indicates cold stage climate. Then, ice wedge growth stopped due to highly increased sedimentation rates and eventually a rise in temperature. Full interglacial climate conditions existed during accumulation of an organic-rich layer - plant macrofossils reflected open forest vegetation existing under dry conditions during Marine Isotope Stage (MIS) 5e. The Late Pleistocene YIC (MIS 4-MIS 2) suggests severe cold-stage climate conditions. No alas deposits, potentially indicating thermokarst processes, were detected at the site. A detailed comparison

  18. El maltrato de género en «Te doy mis ojos» (2003

    Directory of Open Access Journals (Sweden)

    Rosendo BUGARÍN GONZÁLEZ

    2016-04-01

    Full Text Available En nuestro país son escasas y de muy reciente aparición las películas que tratan sobre la violencia de género desde una óptica de rechazo y denuncia. Probablemente la más representativa sea Te doy mis ojos. Su visionado pretende contribuir a concienciar y a hacer reflexionar al espectador sobre la grave dad de esta lacra en nuestra sociedad. No cabe duda de que para llevar a cabo este proyecto, sus respon sables tuvieron que emprender una muy seria y rigurosa labor de investigación. En efecto, este film es un auténtico manual (o incluso tratado sobre maltrato de género. En él se recoge prácticamente “todo” lo relacionado con este problema de salud: el círculo de la violencia, el plan de huída, las consultas sanitarias que no detectaron el problema, el sufrimiento de la víctima, su necesidad de apoyo y acompañamiento así como el contexto del maltratador.

  19. On the energy distribution profile of interface states obtained by taking into account of series resistance in Al/TiO{sub 2}/p-Si (MIS) structures

    Energy Technology Data Exchange (ETDEWEB)

    Pakma, O., E-mail: osman@pakma.co [Department of Physics, Faculty of Sciences and Arts, Batman University, Batman (Turkey); Serin, N.; Serin, T. [Department of Engineering Physics, Faculty of Engineering, Ankara University, 06100 Tandogan, Ankara (Turkey); Altindal, S. [Physics Department, Faculty of Arts and Sciences, Gazi University, Teknikokullar, 06500 Ankara (Turkey)

    2011-02-15

    The energy distribution profile of the interface states (N{sub ss}) of Al/TiO{sub 2}/p-Si (MIS) structures prepared using the sol-gel method was obtained from the forward bias current-voltage (I-V) characteristics by taking into account both the bias dependence of the effective barrier height ({phi}{sub e}) and series resistance (R{sub s}) at room temperature. The main electrical parameters of the MIS structure such as ideality factor (n), zero-bias barrier height ({phi}{sub b0}) and average series resistance values were found to be 1.69, 0.519 eV and 659 {Omega}, respectively. This high value of n was attributed to the presence of an interfacial insulator layer at the Al/p-Si interface and the density of interface states (N{sub ss}) localized at the Si/TiO{sub 2} interface. The values of N{sub ss} localized at the Si/TiO{sub 2} interface were found with and without the R{sub s} at 0.25-E{sub v} in the range between 8.4x10{sup 13} and 4.9x10{sup 13} eV{sup -1} cm{sup -2}. In addition, the frequency dependence of capacitance-voltage (C-V) and conductance-voltage (G/{omega}-V) characteristics of the structures have been investigated by taking into account the effect of N{sub ss} and R{sub s} at room temperature. It can be found out that the measured C and G/{omega} are strongly dependent on bias voltage and frequency. -- Research highlights: {yields}We successfully fabricated Al/TiO{sub 2}/p-Si device with interlayer by a sol-gel method. The facts: (i) that the technology of the fabrication of a Al/TiO{sub 2}/p-Si MIS structure much simpler and economical than that for the Si p-n junction and (b) the main advantages of TiO{sub 2} films are low densities of the surface states when compared to SiO{sub 2}.

  20. Paradigma Shalat Jum’at dalam Hadits Nabi

    Directory of Open Access Journals (Sweden)

    M. Ridwan Hasbi

    2012-06-01

    Full Text Available Shalat jum‘at sebelum direkontruksi oleh ulama Mazahib seperti sekarang ini, terdapat fenomenal jika dirujuk kepada riwayat-riwayat yang menjelaskannya. Sebab ayat yang menjelaskan tentang shalat jum‘at turun di Madinah, tapi pelaksanaannya sudah ada sebelum hijrah dan saat Nabi SAW hijrah sebelum sampai ke Madinah. Penulis menemukan bahwa shalat jum‘at sebelum hijrah yang sudah dilaksanakan di Madinah dan saat Nabi SAW di Quba adalah shalat zuhur plus khutbah. Pada awalnya khutbah setelah shalat, tapi saat terjadi orang-orang meninggalkan Nabi saat khutbah dan turun ayat, maka diubah menjadi khutbah dulu baru shalat, lalu terkontruksi shalat dua rakaat. Waktu pelaksanaannya terdapat perbedaan riwayat dengan ungkapan waktu dhuha, sebelum tengah hari, saat tengah hari dan setelah matahari tergelincir, dengan esensial shalat jum‘at sama dengan shalat ‘id (hari raya. Jumlah jamaah yang menjadi wajibnya shalat tidak terdapat kesepakatan dan kewajiban bagi mukallaf sebab riwayat-riwayatnya bersifat umum dan berbeda satu dengan lainnya.

  1. Reconstruction of MIS 5 climate in the central Levant using a stalagmite from Kanaan Cave, Lebanon

    Science.gov (United States)

    Nehme, C.; Verheyden, S.; Noble, S. R.; Farrant, A. R.; Sahy, D.; Hellstrom, J.; Delannoy, J. J.; Claeys, P.

    2015-12-01

    Lying at the transition between the temperate Mediterranean domain and subtropical deserts, the Levant is a key area to study the palaeoclimatic response over glacial-interglacial cycles. This paper presents a precisely dated last interglacial (MIS 5) stalagmite (129-84 ka) from the Kanaan Cave, Lebanon. Variations in growth rate and isotopic records indicate a warm humid phase at the onset of the last interglacial at ~ 129 ka that lasted until ~ 125 ka. A gradual shift in speleothem isotopic composition (125-122 ka) is driven mainly by the δ18O source effect of the eastern Mediterranean surface waters during sapropel 5 (S5). The onset of glacial inception began after ~ 122 ka, interrupted by a short wet pulse during the sapropel 4 (S4) event. Low growth rates and enriched oxygen and carbon values until ~ 84 ka indicate a transition to drier conditions during Northern Hemisphere glaciation.

  2. PEMBANGUNAN PEMANTAU KINERJA JARINGAN KOMPUTER MELALUI REMASTERING UBUNTU

    Directory of Open Access Journals (Sweden)

    Andi Pebriananta

    2011-01-01

    Full Text Available Pada saat ini Distribusi Linux yang berkembang sangat beraneka macam, tetapi yang cocok untuk memenuhi kebutuhan pemantau kinerja jaringan komputer masih sedikit. Paper ini berfokus pada pembangunan Distribusi Linux yang memiliki aplikasi standar khusus untuk pemantauan kinerja jaringan komputer. Distribusi Linux yang dibangun diturunkan dari Distribusi Linux Ubuntu Karmic Koala dengan teknik remastering. Sulolinuz adalah hasil Distribusi Linux baru ini, dengan perancangan aplikasi khusus pemantau kinerja jaringan yang digunakan kinerja Sulolinuz lebih efisien dari Ubuntu Karmic Koala. Sulolinuz memiliki performa yang lebih cepat dalam hal time respon pada saat melakukan booting dan shutdown. Sulolinuz lebih unggul dalam penggunaan RAM dan CPU saat melakukan proses pemantauan kinerja jaringan maupun saat berada dalam posisi idle.

  3. Capacitance-voltage characteristics of (Al/Ti)/Al{sub 2}O{sub 3}/n-GaN MIS structures

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, P. A., E-mail: Pavel.Ivanov@mail.ioffe.ru; Potapov, A. S.; Nikolaev, A. E.; Lundin, V. V.; Sakharov, A. V.; Tsatsulnikov, A. F. [Russian Academy of Sciences, Ioffe Institute (Russian Federation); Afanas’ev, A. V.; Romanov, A. A.; Osachev, E. V. [St. Petersburg Electrotechnical University LETI (Russian Federation)

    2015-08-15

    The capacitance-voltage characteristics of (Al/Ti)/Al{sub 2}O{sub 3}/n-GaN metal—insulator-semiconductor (MIS) structures are measured and analyzed. n-Type GaN films are grown on sapphire (0001) substrates by the metal-organic chemical vapor deposition method. An aluminum-oxide layer with a thickness of 60 nm is deposited onto the surface of GaN by the method of atomic-layer deposition from the gas phase. Metallic contacts are deposited by the electron-beam evaporation of titanium and aluminum in vacuum. According to the measurement results, the breakdown-field strength of the oxide, its dielectric constant, and the integrated electron density of states at the oxide-semiconductor interface are 5 × 10{sup 6} V/cm, 7.5, and 3 × 10{sup 12} cm{sup −2}, respectively.

  4. Tsunami deposits at MIS Stages 5e and 9 on Oahu, Hawaii: implications for sea level at interglacial stages

    Science.gov (United States)

    McMurtry, G. M.; Campbell, J. F.; Fryer, G. J.; Tappin, D. R.; Fietzke, J.

    2010-12-01

    Sandy, basalt-coral conglomerates associated with both beachrock and coral reefs are found at high elevations on Oahu, Hawaii. They have been attributed to either brief, sea level high-stands or storms. The Kahe Point conglomerates are at 12.5 m elevation, whereas the main stage MIS-5e reef at this location has a maximum elevation of 8.2 m. They are loosely consolidated and poorly cemented, graded, poorly sorted, and with varying amounts of basalt and coral clasts ranging from cobble to boulder size. Coral in these deposits has been U-series dated by us at between 120-125 ka (n=5). Four distinct beds, with a gently seaward tilt, are recognized in a road cut section, with each bed composed of a few cm-thick topset bed of fine-grained, shelly, calcareous sand to silt. Similar high elevation conglomerates and 5e reefs are also described at Mokapu and Kaena Points on Oahu, indicating an island-wide deposit. Older coral clasts, dated at 130 to 142 ka (n=6; oldest by alpha spectrometry) found in association with the stage 5e corals suggest reworking and incorporation of older low-stand reef material. The coarse grain size of the conglomerates indicates deposition from a high-energy event; thus a high-stand source is ruled out. We also consider that the overall lithology and up to 0.5 m bed thickness not to be the result of storms; a series of high frequency storm events is considered unlikely. The weight of the evidence in our opinion clearly indicates deposition by a series of tsunami waves. If correct, this has implications for “probabilistic” models of sea level peaks at least 6.6 m higher than present at stage 5e that use such data in their models (e. g., Kopp et al., 2009), at least for Oahu. Within about 2 km of the Kahe deposit, in a road cut at Ko Olina, there is another markedly similar high-energy, sandy basalt-bearing coral conglomerate sequence at 21 to 25 m elevation. There are at least two distinct beds about one meter in thickness, both gently seaward

  5. Aligning and synchronization of MIS5 proxy records from Lake Ohrid (FYROM) with independently dated Mediterranean archives: implications for DEEP core chronology

    Science.gov (United States)

    Zanchetta, Giovanni; Regattieri, Eleonora; Giaccio, Biagio; Wagner, Bernd; Sulpizio, Roberto; Francke, Alex; Vogel, Hendrik; Sadori, Laura; Masi, Alessia; Sinopoli, Gaia; Lacey, Jack H.; Leng, Melanie J.; Leicher, Niklas

    2016-05-01

    The DEEP site sediment sequence obtained during the ICDP SCOPSCO project at Lake Ohrid was dated using tephrostratigraphic information, cyclostratigraphy, and orbital tuning through the marine isotope stages (MIS) 15-1. Although this approach is suitable for the generation of a general chronological framework of the long succession, it is insufficient to resolve more detailed palaeoclimatological questions, such as leads and lags of climate events between marine and terrestrial records or between different regions. Here, we demonstrate how the use of different tie points can affect cyclostratigraphy and orbital tuning for the period between ca. 140 and 70 ka and how the results can be correlated with directly/indirectly radiometrically dated Mediterranean marine and continental proxy records. The alternative age model presented here shows consistent differences with that initially proposed by Francke et al. (2015) for the same interval, in particular at the level of the MIS6-5e transition. According to this new age model, different proxies from the DEEP site sediment record support an increase of temperatures between glacial to interglacial conditions, which is almost synchronous with a rapid increase in sea surface temperature observed in the western Mediterranean. The results show how a detailed study of independent chronological tie points is important to align different records and to highlight asynchronisms of climate events. Moreover, Francke et al. (2016) have incorporated the new chronology proposed for tephra OH-DP-0499 in the final DEEP age model. This has reduced substantially the chronological discrepancies between the DEEP site age model and the model proposed here for the last glacial-interglacial transition.

  6. Autophagy and Mis-targeting of Therapeutic Enzyme in Skeletal Muscle in Pompe Disease

    Science.gov (United States)

    Fukuda, Tokiko; Ahearn, Meghan; Roberts, Ashley; Mattaliano, Robert J.; Zaal, Kristien; Ralston, Evelyn; Plotz, Paul H.; Raben, Nina

    2009-01-01

    Enzyme replacement therapy (ERT) became a reality for patients with Pompe disease, a fatal cardiomyopathy and skeletal muscle myopathy caused by a deficiency of glycogen-degrading lysosomal enzyme acid alpha-glucosidase (GAA). The therapy, which relies on receptor-mediated endocytosis of recombinant human GAA (rhGAA), appears to be effective in cardiac muscle, but less so in skeletal muscle. We have previously shown a profound disturbance of the lysosomal degradative pathway (autophagy) in therapy-resistant muscle of GAA knockout mice (KO). Our findings here demonstrate a progressive age-dependent autophagic build-up in addition to enlargement of glycogen-filled lysosomes in multiple muscle groups in the KO. Trafficking and processing of the therapeutic enzyme along the endocytic pathway appear to be affected by the autophagy. Confocal microscopy of live single muscle fibers exposed to fluorescently labeled rhGAA indicates that a significant portion of the endocytosed enzyme in the KO was trapped as a partially processed form in the autophagic areas instead of reaching its target – the lysosomes. A fluid-phase endocytic marker was similarly mis-targeted and accumulated in vesicular structures within the autophagic areas. These findings may explain why ERT often falls short of reversing the disease process, and point to new avenues for the development of pharmacological intervention. PMID:17008131

  7. Mis-segmentation in voxel-based morphometry due to a signal intensity change in the putamen.

    Science.gov (United States)

    Goto, Masami; Abe, Osamu; Miyati, Tosiaki; Aoki, Shigeki; Gomi, Tsutomu; Takeda, Tohoru

    2017-12-01

    The aims of this study were to demonstrate an association between changes in the signal intensity of the putamen on three-dimensional T1-weighted magnetic resonance images (3D-T1WI) and mis-segmentation, using the voxel-based morphometry (VBM) 8 toolbox. The sagittal 3D-T1WIs of 22 healthy volunteers were obtained for VBM analysis using the 1.5-T MR scanner. We prepared five levels of 3D-T1WI signal intensity (baseline, same level, background level, low level, and high level) in regions of interest containing the putamen. Groups of smoothed, spatially normalized tissue images were compared to the baseline group using a paired t test. The baseline was compared to the other four levels. In all comparisons, significant volume changes were observed around and outside the area that included the signal intensity change. The present study demonstrated an association between a change in the signal intensity of the putamen on 3D-T1WI and changed volume in segmented tissue images.

  8. [Efficacy of the program "Testas's (mis)adventures" to promote the deep approach to learning].

    Science.gov (United States)

    Rosário, Pedro; González-Pienda, Julio Antonio; Cerezo, Rebeca; Pinto, Ricardo; Ferreira, Pedro; Abilio, Lourenço; Paiva, Olimpia

    2010-11-01

    This paper provides information about the efficacy of a tutorial training program intended to enhance elementary fifth graders' study processes and foster their deep approaches to learning. The program "Testas's (mis)adventures" consists of a set of books in which Testas, a typical student, reveals and reflects upon his life experiences during school years. These life stories are nothing but an opportunity to present and train a wide range of learning strategies and self-regulatory processes, designed to insure students' deeper preparation for present and future learning challenges. The program has been developed along a school year, in a one hour weekly tutorial sessions. The training program had a semi-experimental design, included an experimental group (n=50) and a control one (n=50), and used pre- and posttest measures (learning strategies' declarative knowledge, learning approaches and academic achievement). Data suggest that the students enrolled in the training program, comparing with students in the control group, showed a significant improvement in their declarative knowledge of learning strategies and in their deep approach to learning, consequently lowering their use of a surface approach. In spite of this, in what concerns to academic achievement, no statistically significant differences have been found.

  9. MIS High-Purity Plutonium Oxide Metal Oxidation Product TS707001 (SSR123): Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Veirs, Douglas Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stroud, Mary Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Berg, John M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Narlesky, Joshua Edward [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Worl, Laura Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Martinez, Max A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carillo, Alex [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-09

    A high-purity plutonium dioxide material from the Material Identification and Surveillance (MIS) Program inventory has been studied with regard to gas generation and corrosion in a storage environment. Sample TS707001 represents process plutonium oxides from several metal oxidation operations as well as impure and scrap plutonium from Hanford that are currently stored in 3013 containers. After calcination to 950°C, the material contained 86.98% plutonium with no major impurities. This study followed over time, the gas pressure of a sample with nominally 0.5 wt% water in a sealed container with an internal volume scaled to 1/500th of the volume of a 3013 container. Gas compositions were measured periodically over a six year period. The maximum observed gas pressure was 138 kPa. The increase over the initial pressure of 80 kPa was primarily due to generation of nitrogen and carbon dioxide gas in the first six months. Hydrogen and oxygen were minor components of the headspace gas. At the completion of the study, the internal components of the sealed container showed signs of corrosion, including pitting.

  10. Coral Reef Response to Marine Isotope Stage (MIS) 5e Sea Level Changes in the Granitic Seychelles

    Science.gov (United States)

    Vyverberg, K.; Dechnik, B.; Dutton, A.; Webster, J.; Zwartz, D.

    2015-12-01

    Sea-level position has a direct control on coral reef morphology and composition. Examining changes in these parameters in fossil reefs can inform reconstructions of past sea-level behavior and, indirectly, ice sheet dynamics. Here we provide a detailed examination of fossil reefs from Marine Isotope Stage (MIS) 5e. These fossil reefs are located in the granitic Seychelles, which is tectonically stable site and far-field from the former margins of Northern Hemisphere ice sheets. To reconstruct relative sea level (RSL), we combine RTK and Total Station elevation surveys with sedimentary and taxonomic evaluations of eight fossil reef sites. Carbonate coralgal reef buildups of the shallowest portion of the reef are preserved in limestone outcrops that are protected by granite boulder overhangs. Two primary outcrop morphologies were observed at these sites: plastering and massive. Plastering outcrops manifest as thin (~ 1 m height x 1 m width x 0.5 m depth) vertical successions of reef framework and detritus, while massive outcrops are larger (~ 2-6 m height x 2-6 m width x 1-2 m depth). The base of these limestone outcrops consistently record a period of reef growth, characterized by corals or coralline algae colonizing the surface or face of a granite boulder and building upwards. This lower reefal unit is capped by a disconformity that is commonly overlain by coral rubble or a ~10 cm thick layer of micrite. Rubble units contain coarse fragments of the coralgal reef buildups while micrite layers consist of a relatively homogeneous fine-grained carbonate, bearing coral-dwelling, Pyrgomatid barnacles. In many of the outcrops, this succession is repeated upsection with another unit of coralgal reef framework capped by a disconformity that is recognized by the sharp transition to coral rubble or micrite with barnacles. We identified four distinct fossil coralgal assemblages in the limestone outcrops. These assemblages are consistent with modern assemblages which

  11. Analgesia (mis)usage on a dental emergency service: a patient survey.

    Science.gov (United States)

    Hommez, Geert; Ongena, B; Cauwels, R G E C; De Paepe, P; Christiaens, V; Jacquet, W

    2018-04-01

    Analgesics are one of the most frequently used medicines. Self-medication and misuse have been described in the literature. The purpose of this study was to document analgesic (mis)use in a population seeking emergency dental treatment. Patients consulting a dental emergency service were randomly asked to complete a questionnaire on analgesic use, knowledge and information on the analgesics and on their pain history. A photobook was used as an aid to identify products used. Descriptive statistics were combined with chi-square and Mann-Whitney U testing. Ninety-eight patients were included. Acetaminophen (69.4%) and ibuprofen (65.3%) were the most frequently used products. Nearly half of the subjects (43.9%) combined at least two analgesics. Although 42.9% of subjects were aware of the maximum daily dose, 62.2% of the subjects exceeded this limit, specifically 76.6% of subjects using ibuprofen and 32.4% of subjects using acetaminophen overdosing. Females overdosed significantly more than males. Ingestion on medical advice did not affect the overdose rates significantly. No significant relation was found between the absence of knowledge on the maximum daily dose and actual overdosing. No higher pain reduction was found in patients overdosing analgesics. The average number of days patients experienced pain before consulting the emergency unit was 12. A significant relation was found between the lag time and overdosing. A large portion of the patients overdosed analgesics. Even prior medical advice did not reduce significantly overdose rates. Dentists treating emergency cases clearly need to be aware of the high risk and high rates of overdosing analgesics in their patients.

  12. Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3 and Increased Glomerular Factor H–Related Protein-5 (FHR5 Deposition

    Directory of Open Access Journals (Sweden)

    Nicholas R. Medjeral-Thomas

    2018-03-01

    Conclusion: Our data indicate that circulating MASP-3 levels could be used as a biomarker of disease severity in IgAN and that glomerular staining for FHR5 could both indicate alternative complement pathway activation and be a tissue marker of disease severity.

  13. Müüdid ja mälestused mõttelennu meelevallas / Aita Kivi

    Index Scriptorium Estoniae

    Kivi, Aita, 1954-

    2000-01-01

    Sisu : Maimu Berg. Ära; Liam O'Flaherty. Must org; Victoria Holt. Menfreya; Tomás Eloy MartÍnez. Püha Evita; Ervin Õunapuu. Teie mälestuseks, kes iganes te olete ja kus asute; Anne Kahro. Viie kella tee

  14. Enhancement mode operation in AlInN/GaN (MIS)HEMTs on Si substrates using a fluorine implant

    International Nuclear Information System (INIS)

    Zaidi, Z H; Lee, K B; Qian, H; Jiang, S; Houston, P A; Guiney, I; Wallis, D J; Humphreys, C J

    2015-01-01

    We have demonstrated enhancement mode operation of AlInN/GaN (MIS)HEMTs on Si substrates using the fluorine treatment technique. The plasma RF power and treatment time was optimized to prevent the penetration of the fluorine into the channel region to maintain high channel conductivity and transconductance. An analysis of the threshold voltage was carried out which defined the requirement for the fluorine sheet concentration to exceed the charge at the dielectric/AlInN interface to achieve an increase in the positive threshold voltage after deposition of the dielectric. This illustrates the importance of control of both the plasma conditions and the interfacial charge for a reproducible threshold voltage. A positive threshold voltage of +3 V was achieved with a maximum drain current of 367 mA mm −1 at a forward gate bias of 10 V. (paper)

  15. Investigation of diode parameters using I-V and C-V characteristics of In/SiO{sub 2}/p-Si (MIS) Schottky diodes

    Energy Technology Data Exchange (ETDEWEB)

    Yueksel, O.F. [Department of Physics, Faculty of Arts and Science, Selcuk University, Kampus, Konya 42075 (Turkey)], E-mail: fyuksel@selcuk.edu.tr; Selcuk, A.B.; Ocak, S.B. [PK, 14 Etlik, Ankara (Turkey)

    2008-08-01

    A study on interface states density distribution and characteristic parameters of the In/SiO{sub 2}/p-Si (MIS) capacitor has been made. The thickness of the SiO{sub 2} film obtained from the measurement of the corrected capacitance in the strong accumulation region for MIS Schottky diodes was 220 A. The diode parameters from the forward bias I-V characteristics such as ideality factor, series resistance and barrier heights were found to be 1.75, 106-112 {omega} and 0.592 eV, respectively. The energy distribution of the interface state density D{sub it} was determined from the forward bias I-V characteristics by taking into account the bias dependence of the effective barrier height. The interface state density obtained using the I-V characteristics had an exponential growth, with bias towards the top of the valance band, from 9.44x10{sup 13} eV{sup -1} cm{sup -2} in 0.329-E{sub v} eV to 1.11x10{sup 13} eV{sup -1} cm{sup -2} in 0.527-E{sub v} eV at room temperature. Furthermore, the values of interface state density D{sub it} obtained by the Hill-Coleman method from the C-V characteristics range from 52.9x10{sup 13} to 1.11x10{sup 13} eV{sup -1} cm{sup -2} at a frequency range of 30kHz-1 MHz. These values of D{sub it} and R{sub s} were responsible for the non-ideal behaviour of I-V and C-V characteristics.

  16. Luisa Värk: olen kriitiline ja liiga ambitsioonikas / Luisa Värk ; küsitles Triin Kalter

    Index Scriptorium Estoniae

    Värk, Luisa, 1987-

    2007-01-01

    Intervjuu annab TV 3 saate "Eesti otsib superstaari" finaalis viimase võistlejana välja hääletatud Luisa Värk. Saates osalemisest. Luisa õpib Tallinna Ülikooli Balti Filmi- ja Meediakoolis helirežiid

  17. A modeling experiment on the grounding of an ice shelf in the central Arctic Ocean during MIS 6

    Science.gov (United States)

    Jakobsson, M.; Siegert, M.; Paton, M.

    2003-12-01

    High-resolution chirp sonar subbottom profiles from the Lomonosov Ridge in the central Arctic Ocean, acquired from the Swedish icebreaker Oden in 1996, revealed large-scale erosion of the ridge crest down to depths of 1000 m below present sea level [Jakobsson, 1999]. Subsequent acoustic mapping during the SCICEX nuclear submarine expedition in 1999 showed glacial fluting at the deepest eroded areas and subparallel ice scours from 950 m water depth to the shallowest parts of the ridge crest [Polyak et al., 2001]. The directions of the mapped glaciogenic bed-forms and the redeposition of eroded material on the Amerasian side of the ridge indicate ice flow from the Barents-Kara Sea area. Core studies revealed that sediment drape the eroded areas from Marine Isotope Stage (MIS) 5.5 and, thus, it was proposed that the major erosional event took place during Marine Isotope Stage (MIS) 6 [Jakobsson et al., 2001]. Glacial geological evidence suggests strongly that the Late Saalian (MIS 6) ice sheet margin reached the shelf break of the Barents-Kara Sea [Svendsen et al. in press] and this gives us two possible ways to explain the ice erosional features on the Lomonosov Ridge. One is the grounding of a floating ice shelf and the other is the scouring from large deep tabular iceberg. Here we apply numerical ice sheet modeling to test the hypothesis that an ice shelf emanating from the Barents/Kara seas grounded across part of the Lomonsov Ridge and caused the extensive erosion down to a depth of around 1000 m below present sea level. A series of model experiments was undertaken in which the ice shelf mass balance (surface accumulation and basal melting) and ice shelf strain rates were adjusted. Grounding of the Lomonosov Ridge was not achieved when the ice shelf strain rate was 0.005 yr-1 (i.e. a free flowing ice shelf). However this model produced two interesting findings. First, with basal melt rates of up to 50 cm yr-1 an ice shelf grew from the St. Anna Trough ice stream

  18. Analytical charge control model for AlGaN/GaN MIS-HFETs including an undepleted barrier layer

    Energy Technology Data Exchange (ETDEWEB)

    Shenghui, Lu; Jiangfeng, Du; Qian, Luo; Qi, Yu; Wei, Zhou; Jianxin, Xia; Mohua, Yang, E-mail: lushenghui@sohu.co [State key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 610054 (China)

    2010-09-15

    An analytical charge control model considering the insulator/AlGaN interface charge and undepleted Al-GaN barrier layer is presented for AlGaN/GaN metal-insulator-semiconductor heterostructure field effect transistors (MIS-HFETs) over the entire operation range of gate voltage. The whole process of charge control is analyzed in detail and partitioned into four regions: I-full depletion, II-partial depletion, III-neutral region and IV-electron accumulation at the insulator/AlGaN interface. The results show that two-dimensional electron gas (2DEG) saturates at the boundary of region II/III and the gate voltage should not exceed the 2DEG saturation voltage in order to keep the channel in control. In addition, the span of region II accounts for about 50% of the range of gate voltage before 2DEG saturates. The good agreement of the calculated transfer characteristic with the measured data confirms the validity of the proposed model. (semiconductor devices)

  19. A high-resolution paleosecular variation record from Black Sea sediments indicating fast directional changes associated with low field intensities during marine isotope stage (MIS) 4

    Science.gov (United States)

    Nowaczyk, Norbert R.; Jiabo, Liu; Frank, Ute; Arz, Helge W.

    2018-02-01

    A total of nine sediment cores recovered from the Archangelsky Ridge in the SE Black Sea were systematically subjected to intense paleo- and mineral magnetic analyses. Besides 16 accelerator mass spectrometry (AMS) 14C ages available for another core from this area, dating was accomplished by correlation of short-term warming events during the last glacial monitored by high-resolution X-ray fluorescence (XRF) scanning as maxima in both Ca/Ti and K/Ti ratios in Black Sea sediments to the so-called 'Dansgaard-Oeschger events' recognized from Greenland ice cores. Thus, several hiatuses could be identified in the various cores during the last glacial/interglacial cycle. Finally, core sections documenting marine isotope stage (MIS) 4 at high resolution back to 69 ka were selected for detailed analyses. At 64.5 ka, according to obtained results from Black Sea sediments, the second deepest minimum in relative paleointensity during the past 69 ka occurred, with the Laschamp geomagnetic excursion at 41 ka being associated with the lowest field intensities. The field minimum during MIS 4 is associated with large declination swings beginning about 3 ka before the minimum. While a swing to 50°E is associated with steep inclinations (50-60°) according to the coring site at 42°N, the subsequent declination swing to 30°W is associated with shallow inclinations of down to 40°. Nevertheless, these large deviations from the direction of a geocentric axial dipole field (I = 61 °, D = 0 °) still can not yet be termed as 'excursional', since latitudes of corresponding virtual geomagnetic poles (VGP) only reach down to 51.5°N (120°E) and 61.5°N (75°W), respectively. However, these VGP positions at opposite sides of the globe are linked with VGP drift rates of up to 0.2° per year in between. These extreme secular variations might be the mid-latitude expression of a geomagnetic excursion with partly reversed inclinations found at several sites much further North in Arctic

  20. RANCANG BANGUN SISTEM PENDETEKSI KEBAKARAN LAHAN GAMBUT JENIS KAYUAN DENGAN MEMANFAATKAN KARAKTERISTIK PANAS YANG DITIMBULKANNYA

    Directory of Open Access Journals (Sweden)

    Gilang Bagaskara

    2017-11-01

    Full Text Available Kebakaran lahan gambut yang sudah meluas menimbulkan bencana asap dan penyakit pada masyarakat. Pemantauan kebakaran lahan gambut yang memiliki tingkat akurasi tertinggi adalah ASEAN Specialized Meteorological Center (ASMC dengan tingkat akurasi sebesar 60%. Dibutuhkan perancangan pendeteksi kebakaran lahan gambut, guna untuk mitigasi bencana kebakaran lahan gambut. Karena gambut yang ada di provinsi Riau umumnya adalah gambut jenis kayuan, jadi penelitian dilakukan pada gambut kayuan. Beberapa metode pengambilan data pada penelitian ini yaitu: uji laboratorium, pengambilan data di lahan gambut kondisi normal, pengambilan data di lahan gambut saat kejadian kebakaran dan pemetaan simpul. Berdasarkan hasil penelitian ini, sensor suhu LM35 memiliki tingkat akurasi dengan persen error rata-rata sebesar 0,22%. Suhu lahan gambut kayuan saat kondisi normal memiliki besar suhu yang selalu berada di bawah suhu udara sekitar. Saat kondisi terbakar besar, suhu lahan gambut kayuan terus meningkat dan melebihi besar suhu udara sekitar. Suhu udara sekitar saat kondisi normal atau saat terjadi kebakaran tidak ada perbedaan yang mencolok, karena kebakaran lahan gambut kayuan tidak begitu bergemuruh perubahan suhu udara sekitar. Radius sensor suhu LM35 pada alat pendeteksi kebakaran lahan gambut mencapai 4 m dengan lama waktu pembacaan 45 menit.

  1. Analisa Teknis Pemakaian Kombinasi Lampu Metal Halide Dan Led Sebagai Pemikat Ikan Pada Kapal Pukat Cincin (Purse Seine Dan Pengaruhnya Terhadap Konsumsi Bahan Bakar Genset

    Directory of Open Access Journals (Sweden)

    Septian Ragil Wibisono

    2017-01-01

    Full Text Available Saat ini lampu Metal Halide dipakai sebagai pemikat ikan  oleh nelayan Purse Seine. Peggunaan lampu tersebut memerlukan daya Genset yang besar karena satu lampu Metal Halide berdaya 1500 Watt. Semakin banyak lampu Metal Halide yang digunakan semakin besar pula konsumsi bahan bakar Genset. Dalam upaya penghematan energi bahan bakar maka digunakan lampu LED sebagai alternatif pemikat ikan. Lampu LED dikenal sebagai lampu yang hemat energi. Penelitian ini ditujukan untuk mengetahui dan membandingkan konsumsi bahan bakar Genset saat menggunakan kombinasi lampu Metal Halide dan LED. Penelitian ini dilakukan dengan mengambil data konsumsi bahan bakar Genset untuk menyalakan sejumlah lampu Metal Halide dan lampu LED, kemudian dilakukan analisa regresi untuk mendapatkan model persaamaan konsumsi bahan bakar Genset. Selanjutnya dilakukan ekstrapolasi untuk memprediksi konsumsi bahan bakar saat Genset dengan jumlah lampu tertentu. Hasilnya dengan besar fluks cahaya yang hampir sama, saat penggunaan 6 lampu Metal Halide konsumsi bahan bakar sebesar 13.606,03 liter, dan saat menggunakan kombinasi lampu 1 Metal Halide dan 25 lampu LED konsumsi bahan bakar sebesar 13.255,63 liter, yang artinya terjadi penghematan bahan bakar sebesar 2,58%.

  2. Using bones to shape stones: MIS 9 bone retouchers at both edges of the Mediterranean Sea.

    Directory of Open Access Journals (Sweden)

    Ruth Blasco

    Full Text Available A significant challenge in Prehistory is to understand the mechanisms involved in the behavioural evolution of human groups. The degree of technological and cultural development of prehistoric groups is assessed mainly through stone tools. However, other elements can provide valuable information as well. This paper presents two bone retouchers dated to the Middle Pleistocene MIS 9 used for the shaping of lithic artefacts. Originating from Bolomor Cave (Spain and Qesem Cave (Israel, these two bone retouchers are among the earliest of the Old World. Although the emergence of such tools might be found in the latest phases of the Acheulean, their widespread use seems to coincide with independently emergent post-Acheulean cultural complexes at both ends of the Mediterranean Sea: the post-Acheulean/pre-Mousterian of Western Europe and the Acheulo Yabrudian Cultural Complex of the Levant. Both entities seem to reflect convergent processes that may be viewed in a wider cultural context as reflecting new technology-related behavioural patterns as well as new perceptions in stone tool manufacturing.

  3. Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System.

    Science.gov (United States)

    Santaguida, Stefano; Richardson, Amelia; Iyer, Divya Ramalingam; M'Saad, Ons; Zasadil, Lauren; Knouse, Kristin A; Wong, Yao Liang; Rhind, Nicholas; Desai, Arshad; Amon, Angelika

    2017-06-19

    Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Changes in chromosome copy number have been proposed to drive disease by modulating the dosage of cancer driver genes and by promoting cancer genome evolution. Given the potential of cells with abnormal karyotypes to become cancerous, do pathways that limit the prevalence of such cells exist? By investigating the immediate consequences of aneuploidy on cell physiology, we identified mechanisms that eliminate aneuploid cells. We find that chromosome mis-segregation leads to further genomic instability that ultimately causes cell-cycle arrest. We further show that cells with complex karyotypes exhibit features of senescence and produce pro-inflammatory signals that promote their clearance by the immune system. We propose that cells with abnormal karyotypes generate a signal for their own elimination that may serve as a means for cancer cell immunosurveillance. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Rõõmsa Inglismaa jutuvestja / Lembit Liivak

    Index Scriptorium Estoniae

    Liivak, Lembit

    2006-01-01

    Arvustus: Chaucer, Geoffrey. Canterbury lood / inglise keelest tõlkinud Votele Viidemann ; toimetanud, kommentaaride ja märkustega varustanud Lauri Pilter ; [saatesõna: Arthur Kincaid ; saatesõna tõlkinud Krista Mits]. Tartu : Tartu Ülikooli Kirjastus, 2006 (Maailmakirjanduse tõlkevaramu ; 17)

  5. Linnahallis pidutseti kuulsuse nimel

    Index Scriptorium Estoniae

    2006-01-01

    Pühapäeval peale "Fame" etendust peeti pidu, mida alustati ühiselt saate "Tantsud tähtedega" vaatamisega, kuna pühapäevaõhtuid veedab lavaloo lavastaja ja koreograaf Jüri Nael Kanal 2 saates "Tantsud tähtedega"

  6. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

    Science.gov (United States)

    Kiryluk, Krzysztof; Li, Yifu; Scolari, Francesco; Sanna-Cherchi, Simone; Choi, Murim; Verbitsky, Miguel; Fasel, David; Lata, Sneh; Prakash, Sindhuri; Shapiro, Samantha; Fischman, Clara; Snyder, Holly J.; Appel, Gerald; Izzi, Claudia; Viola, Battista Fabio; Dallera, Nadia; Vecchio, Lucia Del; Barlassina, Cristina; Salvi, Erika; Bertinetto, Francesca Eleonora; Amoroso, Antonio; Savoldi, Silvana; Rocchietti, Marcella; Amore, Alessandro; Peruzzi, Licia; Coppo, Rosanna; Salvadori, Maurizio; Ravani, Pietro; Magistroni, Riccardo; Ghiggeri, Gian Marco; Caridi, Gianluca; Bodria, Monica; Lugani, Francesca; Allegri, Landino; Delsante, Marco; Maiorana, Mariarosa; Magnano, Andrea; Frasca, Giovanni; Boer, Emanuela; Boscutti, Giuliano; Ponticelli, Claudio; Mignani, Renzo; Marcantoni, Carmelita; Di Landro, Domenico; Santoro, Domenico; Pani, Antonello; Polci, Rosaria; Feriozzi, Sandro; Chicca, Silvana; Galliani, Marco; Gigante, Maddalena; Gesualdo, Loreto; Zamboli, Pasquale; Maixnerová, Dita; Tesar, Vladimir; Eitner, Frank; Rauen, Thomas; Floege, Jürgen; Kovacs, Tibor; Nagy, Judit; Mucha, Krzysztof; Pączek, Leszek; Zaniew, Marcin; Mizerska-Wasiak, Małgorzata; Roszkowska-Blaim, Maria; Pawlaczyk, Krzysztof; Gale, Daniel; Barratt, Jonathan; Thibaudin, Lise; Berthoux, Francois; Canaud, Guillaume; Boland, Anne; Metzger, Marie; Panzer, Ulf; Suzuki, Hitoshi; Goto, Shin; Narita, Ichiei; Caliskan, Yasar; Xie, Jingyuan; Hou, Ping; Chen, Nan; Zhang, Hong; Wyatt, Robert J.; Novak, Jan; Julian, Bruce A.; Feehally, John; Stengel, Benedicte; Cusi, Daniele; Lifton, Richard P.; Gharavi, Ali G.

    2014-01-01

    We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six novel genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geo-spatial distribution of risk alleles is highly suggestive of multi-locus adaptation and the genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shaping the genetic landscape of IgAN. PMID:25305756

  7. Pathological Role of Tonsillar B Cells in IgA Nephropathy

    Directory of Open Access Journals (Sweden)

    Yusuke Suzuki

    2011-01-01

    Full Text Available Although impaired immune regulation along the mucosa-bone marrow axis has been postulated to play an important role, the pathogenesis of IgA nephropathy (IgAN is unknown; thus, no disease-specific therapy for this disease exists. The therapeutic efficacy of tonsillectomy or tonsillectomy in combination with steroid pulse therapy for IgAN has been discussed. Although randomized control trials for these therapies are ongoing in Japan, the scientific rationale for these therapies remains obscure. It is now widely accepted that abnormally glycosylated IgA1 and its related immune complex (IC are probably key molecules for the pathogenesis, and are thus considered possible noninvasive biomarkers for this disease. Emerging evidence indicates that B cells in mucosal infections, particularly in tonsillitis, may produce the nephritogenic IgA. In this paper, we briefly summarize characteristics of the nephritogenic IgA/IgA IC, responsible B cells, and underlying mechanisms. This clinical and experimental information may provide important clues for a therapeutic rationale.

  8. Social Awareness and Action Training (SAAT)

    Science.gov (United States)

    2012-04-01

    C. (1998). Sexual harassment and assault as predictors of PTSD symptomatology among U.S. female Persian Gulf War Military Personnel. Journal of...posttraumatic stress disorder (PTSD), divorce, mental-health issues, domestic abuse, sexual assault, weight gain, low re-enlis tment r<ltes, and attrition...Soldier Fitness program. At the level of neurophysiology, researchers target oxytocin and various mechanisms of social reward such as dopamine and

  9. Social Awareness and Action Training (SAAT)

    Science.gov (United States)

    2015-06-01

    169-190. Bolier, L., Haverman, M., Westerhof, G. J., Riper, H., Smit, F., & Bohlmeijer, E. (2013). Positive psychology interventions: A meat ...Conflict Resolution: Know how to exit the blame game Learn methods for handling conflict that is more about assigning blame than about solving

  10. Social Awareness and Action Training (SAAT)

    Science.gov (United States)

    2013-04-01

    unmarried  Soldiers  showed  a  greater  increase  in  social  fitness  beliefs  than   married ...a  serious  relationship.   19. Marital  status  (MARSTAT,  MAR1).  Current  marital  status  (5  categories);   married ... vs .  Cultural   Awareness)  and  one  within-­‐subject  factor  (Time:  Pretest   vs .  Posttest).  The

  11. Constraining Seasonal and Vertical Distributions of Planktonic Foraminifera for Paleoclimate Reconstruction Since MIS3 at the Axial Seamount, Juan de Fuca Ridge

    Science.gov (United States)

    Chen, S. L.; Ravelo, A. C.; Clague, D. A.

    2015-12-01

    The California Current is an upwelling region with dynamic interactions between circulation, biological productivity and ecology. A 77 cm piston push core was taken from the Juan de Fuca Ridge Axial Seamount using a Remotely Operated Vehicle (ROV) (2213m, 45.55º N, 130.08º W), an active submarine volcano ~480 km off Oregon's coast. Five radiocarbon dates indicate that the sediment ranges from 42.6 ka at 77 cm to 17.6 ka at 15 cm, with an average sediment accumulation rate of 2.47 cm/ka from 77-15 cm, and an average rate of 0.85 cm/ka during the postglacial period (the core representing subtropical, subartic, and arctic fauna have been used to constrain changes in vertical and seasonal temperature since Marine Isotope Stage 3 (MIS3). Measurements of δ18O of the upwelling species Globigerina bulloides, the thermocline dwelling species Neogloboquadrina dutertrei, and the warm mixed-layer species Orbulina universa are offset from each other, reflecting vertical and seasonal variation among the planktonic foraminifera. Of the three species, G. bulloides shows the least variation in δ18O, possibly indicating that marked changes in temperature are masking changes in the δ18O of seawater due to global ice volume changes. G. bulloides and O. universa δ18O values are similar in MIS 3 and diverge with time, indicating the development of strong seasonal succession of species, since the last glacial maximum. Bulk nitrogen isotopes and nitrogen flux provide additional constraints on upwelling strength and insight into local biological productivity and nutrient dynamics. Obtaining Mg/Ca data will clarify the δ 18O interpretation except deep in the core where metal-bearing authigenic precipitates affect Mg concentrations. These climatic proxies together provide insight into how global climate change and local seamount volcanism impacts regional productivity in the California Current.

  12. STUDI AWAL: PENGARUH GAME KEKERASAN TERHADAP AKTIVITAS OTAK ANAK MELALUI PEMETAAN SINYAL OTAK (BRAIN MAPPING MENGGUNAKAN WIRELESS EEG

    Directory of Open Access Journals (Sweden)

    Nita Handayani

    2017-06-01

    Full Text Available Brain mapping adalah pemetaan aktivitas kelistrikan otak untuk mempelajari fungsional otak manusia. Pada studi ini, brain mapping digunakan untuk mempelajari pengaruh game kekerasan terhadap aktivitas fungsional otak anak dengan menggunakan wireless EEG (electroencephalography berupa Emotiv Epoc 14-channel. Subjek penelitian ini adalah anak-anak pecandu game kekerasan (10 anak dengan rentang usia antara 12-15 tahun. Aktivitas otak pada saat bermain game akan dibandingkan dengan kondisi rileks. Waktu perekaman EEG selama 42 menit untuk setiap subjek. Dari hasil analisis spektral daya menggunakan periodogram Welch menunjukkan bahwa pada saat bermain game, frekuensi gelombang delta dan theta meningkat terutama pada area frontal (F7, F3, FC5, FC6, F4, F8, dan AF4. Spektral daya gelombang alpha mengalami penurunan sedangkan gelombang beta mengalami peningkatan pada saat bermain game. Hal ini mengindikasikan bahwa anak mengalami beban mental dan berada pada kondisi stres pada saat bermain game kekerasan.

  13. IgA Nephropathy and Henoch-Schoenlein Purpura Nephritis: Aberrant Glycosylation of IgA1, Formation of IgA1-Containing Immune Complexes, and Activation of Mesangial Cells

    DEFF Research Database (Denmark)

    Novak, J.; Moldoveanu, Z.; Renfrow, M.B.

    2007-01-01

    IgA1 in the circulation and glomerular deposits of patients with IgA nephropathy (IgAN) is aberrantly glycosylated; the hinge-region O-linked glycans are galactose-deficient. The circulating IgA1 of patients with Henoch-Schoenlein purpura nephritis (HSPN) has a similar defect. This aberrancy...

  14. Õnnetute ugrilaste lõputu õnn, ääri-veeri / Art Leete

    Index Scriptorium Estoniae

    Leete, Art, 1969-

    1996-01-01

    Arvustus: Enne koitu : Soome-ugri tõlkeklassikat / Koost. ja tlk. Arvo Valton; Saatesõnad kirjutanud: Eva Vingiano de Pina Martins. - Tln. : Virgela, 1996. nEesti-mari, eesti-komi ja eesti-udmurdi paralleeltekstidega tõlkekogumik. Ka Eva Vingiano de Pina Martinsi (Toulouze'i) saatesõnadest

  15. Emirhan Yeniki’nin “Bir Saatliğine” Hikâyesi Ve Tatar Edebiyatında Savaşın İzleri “For One Hour” Story Of Emirhan Yeniki And The Effects Of War In Tatar Literature

    Directory of Open Access Journals (Sweden)

    Alsu KAMALİEVA

    2013-03-01

    Full Text Available War offers a variety of themes for artists with the tragedies it embodies. The war theme is one of the most challenging themes of literary works. Wars that have been experienced throughout the history of humanity have been worked in various literary genres in world literatures. “War” has been widely discussed in Tatar Literature as well. This is strongly related to the fact that Tatar society deeply experienced the sufferings of World War II. As it is known, the Tatar people had livedclosely with Soviet people and struggled against the Nazi Germany inthe Second World War by taking sides with Soviet Union. Many Tatarwriters and artists had been in the war in person and experienced theprocess. EmirhanYeniki, whose name has exceeded the borders of hiscountry, is one of those Tatar artists who experienced the war andreflected it successfully. “Bir Saatliğine” (For One Hour is a significantstory by EmirhanYeniki which established a place for itself in TatarLiterature among the works of war period. In the story, Yeniki tells usabout the Tatar society during the World War II and the meeting of amother with his youngest son of her three children for one hour byenriching the story with psychological analyses. In the “For One Hour”story, we can find about Tatar village life with all its details within thetechnical possibilities of story genre. In addition, the significance of“train”, the means of transportation where the story was set around,among Tatar society is clearly emphasized in the story. Savaş, trajedileriyle, sanatkârlara geniş bir yelpazede tema çeşitliliği verir. Savaş teması, edebi eserlerin de iddialı temalarından biridir. İnsanlık tarihi boyunca yaşanan savaşlar, dünya edebiyatlarında çeşitli edebî türlerde işlenmiştir. Tatar Edebiyatı’nda da savaş teması geniş bir şekilde yer almıştır. Bu durumun ortaya çıkmasında Tatar toplumunun, İkinci Dünya Savaşı’nın bütün acılarını derin

  16. An investigation of the influence of strength mis-matching and HAZ width on the fracture behaviour of welds with cracks in the WM/HAZ interface

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, D.M.; Menezes, L.F.; Loureiro, A. [Dept of Mechanical Eng., FCTUC, Coimbra (Portugal)

    2004-07-01

    In this paper a numerical study concerning the influence of the mis-match in mechanical properties and of the heat affected zone width on the crack driving force of welds with cracks in the weld metal / heat affected zone interface is described. This work was performed through the numerical simulation of three-point bending tests, using finite element meshes of weld samples with various HAZ widths and two different crack length sizes. The numerical calculation of the J integral and of the stress fields ahead the notch tip was used to evaluate the fracture strength variation in the welds. (orig.)

  17. Perancangan Simulasi Operasi Angkutan Batubara Berbasis Web Programming (Studi Kasus: Pendangkalan di Sungai Barito

    Directory of Open Access Journals (Sweden)

    Jauhari Alafi

    2012-09-01

    Full Text Available Batubara di PT. ZXC diangkut dari dermaga tambang melalui Sungai Barito menggunakan tongkang untuk kemudian di transitkan ke mother vessel. Kendala yang dialami oleh tongkang adalah ketika musim kemarau level air sungai Barito turun drastis, apalagi di daerah dekat hulu sungai. Pada saat hal itu terjadi, sungai yang biasanya bisa dilewati oleh tongkang hingga kapasitas 5.000 ton, hanya bisa dilewati tongkang tersebut apabila mengurangi muatannya hingga 2.000 ton saja. Bahkan ketika pada kondisi level air terrendah, tongkang-tongkang tidak bisa melaluinya sama sekali. Berdasarkan hasil simulasi, skenario terbaik bagi PT. ZXC dalam mencapai target penjualan sebesar 2,5 juta ton adalah dengan tetap mengoperasikan seluruh tongkang yang ada pada saat terjadi pendangkalan, meskipun tongkang tidak dapat berlayar dengan muatan penuh. Karena total biaya untuk opsi 1 (tidak ada pengangkutan pada saat sungai dangkal adalah sebesar Rp 81.046.464.410, sedangkan total biaya untuk opsi 2 (ada pengangkutan pada saat terjadi pendangkalan adalah Rp 55.091.040.758.

  18. Mitotic spindle defects and chromosome mis-segregation induced by LDL/cholesterol-implications for Niemann-Pick C1, Alzheimer's disease, and atherosclerosis.

    Directory of Open Access Journals (Sweden)

    Antoneta Granic

    Full Text Available Elevated low-density lipoprotein (LDL-cholesterol is a risk factor for both Alzheimer's disease (AD and Atherosclerosis (CVD, suggesting a common lipid-sensitive step in their pathogenesis. Previous results show that AD and CVD also share a cell cycle defect: chromosome instability and up to 30% aneuploidy-in neurons and other cells in AD and in smooth muscle cells in atherosclerotic plaques in CVD. Indeed, specific degeneration of aneuploid neurons accounts for 90% of neuronal loss in AD brain, indicating that aneuploidy underlies AD neurodegeneration. Cell/mouse models of AD develop similar aneuploidy through amyloid-beta (Aß inhibition of specific microtubule motors and consequent disruption of mitotic spindles. Here we tested the hypothesis that, like upregulated Aß, elevated LDL/cholesterol and altered intracellular cholesterol homeostasis also causes chromosomal instability. Specifically we found that: 1 high dietary cholesterol induces aneuploidy in mice, satisfying the hypothesis' first prediction, 2 Niemann-Pick C1 patients accumulate aneuploid fibroblasts, neurons, and glia, demonstrating a similar aneugenic effect of intracellular cholesterol accumulation in humans 3 oxidized LDL, LDL, and cholesterol, but not high-density lipoprotein (HDL, induce chromosome mis-segregation and aneuploidy in cultured cells, including neuronal precursors, indicating that LDL/cholesterol directly affects the cell cycle, 4 LDL-induced aneuploidy requires the LDL receptor, but not Aß, showing that LDL works differently than Aß, with the same end result, 5 cholesterol treatment disrupts the structure of the mitotic spindle, providing a cell biological mechanism for its aneugenic activity, and 6 ethanol or calcium chelation attenuates lipoprotein-induced chromosome mis-segregation, providing molecular insights into cholesterol's aneugenic mechanism, specifically through its rigidifying effect on the cell membrane, and potentially explaining why ethanol

  19. Noored režissöörid väärtustavad eneseleidmist / Maiju Ingman, Anu Aun ; interv. Karin Klaus

    Index Scriptorium Estoniae

    Ingman, Maiju

    2007-01-01

    Pärnus näidatakse noortefilme : soomlanna Maiju Ingmani TÜ lõputööd "Mida iganes, Aleksander" (teekonnafilm, osades Jaak Prints, Arvo Kukumägi) ja Anu Auna lühifilmi "Indigo tuba" (mängivad Mirtel Pohla, Alo Kõrve). Režissöörid oma otsingutest ja filmidest

  20. Using the C-V curve of an mis diode to examine the trapping levels in a semiconductor containing many discrete traps

    Science.gov (United States)

    Cook, R. K.; Kasold, J. P.; Jones, K. A.

    1980-04-01

    It is shown that the trap concentrations and depths can be obtained from the slopes of the ( C/ ci) 2 vs VG curves and the change in ( C/ Ci) 2 at the transition points for an MIS diode, and that this method is particularly applicable to single type semiconductors such as CdS. This is done by developing equations using the abrupt depletion layer model. In this paper the equations are derived, they are used to determine the ideal C-V curves of copper doped CdS, and then they are used to analyze C-V curves of gold doped silicon. Equations are also derived that predict how the C-V curve will be affected when the depletion layer punches through a doped layer, and calculations are made for copper doped CdS.

  1. « Misère au borinage ». Le travail et la pauvreté comme figures de l'art belge plébiscité par la France de 1919 à 1939

    Directory of Open Access Journals (Sweden)

    Céline De Potter

    2009-05-01

    Full Text Available « Misère au borinage », le titre de cet article rend hommage au documentaire des cinéastes Henri Storck et Joris Ivens tourné aux mines du Levant à Mons pendant la grande grève de 1932. Ce film, qui dénonce les conditions de vie des mineurs borains, associe définitivement, en Belgique, pour la période qui nous occupe, la représentation du travail à celle de la pauvreté. Il vient ainsi couronner une longue tradition iconographique belge qui, des Primitifs flamands au statuaire réaliste Constantin Meunier, s’est toujours illustrée dans la description de la douleur, de la misère et de l’effort au travail. Ce que l’on sait moins, par contre, c’est que cette tradition iconographique se poursuivit entre les deux guerres mondiales et eut pour mérite d’intéresser, en France, la plupart des amateurs d’art de cette époque, que ceux-ci soient d’avant-garde ou non.« Misère au borinage », article’s title pays homage to Henri Storck’s and Joris Ivens’s documentary shot at the Levant’s mines near Mons in Belgium during the heavy strikes of 1932. This film which denounces miner’s life conditions definitely associates in Belgium during the interwar years work’s representations with poverty’s representations. Anyway this association is the crowning achievement of a long iconographical tradition that goes from Flemish Primitives to the sculptor Constantin Meunier and that is well-known for its description of pain, extreme poverty and effort at work. Instead of this knowledge, the fact that this iconographical tradition continues during the interwar years is relatively unknown. It nevertheless had a great success in France during that period, as well nearby avant-garde amateurs than nearby “arrière-garde” ones.

  2. ANALISIS FAKTOR YANG BERHUBUNGAN DENGAN KECEMASAN PADA MAHASISWA PROGRAM STUDI DIII KEPERAWATAN AKPER DHARMA WACANA METRO ANGKATAN XXIII SAAT PERTAMA TINGGAL DI ASRAMA

    Directory of Open Access Journals (Sweden)

    Janu Purwono Suyitno

    2016-12-01

    Full Text Available Abstrak   Latar Belakang: Kecemasan adalah sebuah emosi dan pengalaman subyektif dari seseorang. Kecemasan juga dapat diartikan suatu keadaan yang membuat  seseorang tidak nyaman dan terbagi dalam beberapa tingkatan. Jadi cemas berkaitan dengan perasaan yang tidak pasti dan tidak berdaya.Tujuan penelitian  adalah untuk mengetahui faktor-faktor yang berhubungan dengan kecemasan mahasiswa program studi  DIII Keperawatan Akper Dharma wacana Metro Angkatan XXIII saat pertama tinggal di asrama Metode: Jenis penelitian ini bersifat kuantitatif dengan pendekatan Studi Cross Sectional. Jumlah sampel yang digunakan sebanyak 112 responden. Data diperoleh dengan tehnik wawancara menggunakan kuesioner. Analis data menggunakan Uji Chi square, dengan tingkat kepercayaan 95% dan multipel regresi logistik. Hasil:  penelitian  menunjukkan bahwa ada hubungan variabel  tempat tinggal  (p-value = 0,028, hubungan interpersonal (p-value = 0.028, penyesuaian diri (p-value = 0,019 dengan kesemasan, dan tidak ada hubungan persepsi makanan (p-value = 1,000 dan tekanan kelompok (p-value = 0,131. Faktor yang paling dominan berhubungan dengan kecemasn adalah penyesuaian peran diri (OR = 2,012.  Kesimpulan: Tempat tinggal , hubungan interpersonal, penyesuaian diri  berhubungan dengan kecemasan pada mahasiswa Akper Dharma Wacana Metro   Kata Kunci          : Tempat tinggal, hubungan interpersonal, penyesuaian peran diri, kecemasan     Abstract   Background: Anxiety is an emotional and subjective experience of a person. Anxiety can also be interpreted a condition that makes a person uncomfortable and divided into several levels. So anxiety associated with feelings of uncertainty and not berdaya.Tujuan study is to determine the factors associated with anxiety student of Nursing Nursing DIII Dharma discourse Force XXIII Metro first time staying in a dorm. Methods: This research is a quantitative approach Cross Sectional Study. The samples used by 40

  3. Climate, vegetation and lake development at Sokli (northern Finland) during early MIS 3 at approx50 kyr: Revising earlier concepts on climate, glacial and vegetation dynamics in Fennoscandia during the Weichselian

    Energy Technology Data Exchange (ETDEWEB)

    Helmens, Karin F. (Dept. of Physical Geography and Quaternary Geology, Stockholm Univ., Stockholm (Sweden))

    2009-08-15

    Long sediment records that register environmental changes in formerly glaciated regions such as Fennoscandia in the period preceding the Last Glacial Maximum (LGM) at approx 20 kyr are rare. The Weichselian history of Fennoscandia is based on the long-distance correlation of poorly dated stratigraphic fragmentary evidence and studies on glacial geomorphology. Environmental conditions during ice-free intervals have been mostly reconstructed based on low resolution palynological analysis only. Here we present the results of a detailed study of a for Fennoscandia unusually long and continuous sediment sequence that has been recovered from the Sokli basin in northern Finland. The Sokli sequence consists of tills, glacio-fluvial beds, and fluvial beds, interlayered with fossil-rich lacustrine sediments that according to multiple accelerator mass spectrometer (AMS) 14C and optically stimulated luminescence (OSL) datings extend from the present into the Penultimate Glacial representing the last approx130 kyr. This report focuses on the youngest Weichselian interstadial interval with ice-free conditions at Sokli dated to approx50 kyr in the early part of Marine Isotope Stage (MIS) 3. A comprehensive environmental reconstruction is made based on multi-proxy analysis on a two meter thick laminated, lacustrine clay-silt sequence, including lithological characteristics; organic content (loss-on-ignition, LOI); plant microfossils (pollen, spores, algal and fungal remains); macrofossils of plants (e.g. seeds, moss remains) and of aquatic animals (e.g. statoblasts of Bryozoa); head-capsules of chironomids (i.e. aquatic insects); and diatoms and other siliceous microfossils (e.g. phytolits, chrysophyte stomatocysts). Additionally, geomorphic evidence and analysis of Digital Elevation Model (DEM) data are employed in the environmental reconstruction. Mean July temperatures are reconstructed by applying transfer functions to the pollen, chironomid and diatom records. The results

  4. Unmasking of complements using proteinase-K in formalin fixed paraffin embedded renal biopsies

    Directory of Open Access Journals (Sweden)

    R Nada

    2016-01-01

    Full Text Available Renal biopsy interpretation requires histopathology, direct immunofluorescence (DIF and electron microscopy. Formalin-fixed, paraffin-embedded tissue (FFPE sent for light microscopy can be used for DIF after antigen retrieval. However, complement staining has not been satisfactory. We standardized DIF using proteinase-K for antigen retrieval in FFPE renal biopsies. A pilot study was conducted on known cases of membranous glomerulonephritis (MGN, membranoproliferative type-1 (MPGN-1, immunoglobulin A nephropathy (IgAN, and anti-glomerular basement disease (anti-GBM. Immunofluorescence panel included fluorescein isothiocyanate (FITC conjugated IgG, IgA, IgM, complements (C3 and C1q, light chains (kappa, lambda and fibrinogen antibodies. After standardization of the technique, 75 renal biopsies and 43 autopsies cases were stained. Out of 43 autopsy cases, immune-complex mediated glomerulonephritis (GN was confirmed in 18 cases (Lupus nephritis-11, IgAN-6, MGN-1, complement-mediated dense deposit disease (DDD-1 and monoclonal diseases in 4 cases (amyloidosis-3, cast nephropathy-1. Immune-mediated injury was excluded in 17 cases (focal segmental glomerulosclerosis -3, crescentic GN-6 [pauci-immune-3, anti-GBM-3], thrombotic microangiopathy-5, atherosclerosis-3. Renal biopsies (n-75 where inadequate or no frozen sample was available; this technique classified 52 mesangiocapillary pattern as MPGN type-1-46, DDD-2 and (C3GN-4. Others were diagnosed as IgAN-3, lupus nephritis-2, MGN-4, diffuse proliferative glomerulonephritis (DPGN-1, Non-IC crescentic GN-1, monoclonal diseases-3. In nine cases, DIF on FFPE tissue could not help in making diagnosis. Proteinase-K enzymatic digestion of FFPE renal biopsies can unmask complements (both C3 and C1q in immune-complexes mediated and complement-mediated diseases. This method showed good results on autopsy tissues archived for as long as 15 years.

  5. New treatment for IgA nephropathy: enteric budesonide targeted to the ileocecal region ameliorates proteinuria.

    Science.gov (United States)

    Smerud, Hilde Kloster; Bárány, Peter; Lindström, Karin; Fernström, Anders; Sandell, Anna; Påhlsson, Peter; Fellström, Bengt

    2011-10-01

    Systemic corticosteroid treatment has been shown to exert some protection against renal deterioration in IgA nephropathy (IgAN) but is not commonly recommended for long-term use due to the well-known systemic side effects. In this study, we investigated the efficacy and safety of a new enteric formulation of the locally acting glucocorticoid budesonide (Nefecon®), designed to release the active compound in the ileocecal region. The primary objective was to evaluate the efficacy of targeted release budesonide on albuminuria. Budesonide 8 mg/day was given to 16 patients with IgAN for 6 months, followed by a 3-month follow-up period. The efficacy was measured as change in 24-h urine albumin excretion, serum creatinine and estimated glomerular filtration rate (eGFR). The median relative reduction in urinary albumin excretion was 23% during the treatment period (interquartile range: -0.36 to -0.04, P = 0.04) with pretreatment values ranging from 0.3 to 6 g/24 h (median: 1.5 g/24 h). The median reduction in urine albumin peaked at 40% (interquartile range: -0.58 to -0.15) 2 months after treatment discontinuation. Serum creatinine was reduced by 6% (interquartile range: -0.12 to -0.02; P = 0.003), and eGFR [Modification of Diet in Renal Disease (MDRD)] increased ∼8% (interquartile range: 0.02-0.16, P = 0.003) during treatment. No major corticosteroid-related side effects were observed. In the present pilot study, enteric budesonide targeted to the ileocecal region had a significant effect on urine albumin excretion, accompanied by a minor reduction of serum creatinine and a modest increase of eGFR calculated by the MDRD equation, while eGFR calculated from Cockcroft-Gault equation and cystatin C was not changed. Enteric budesonide may represent a new treatment of IgAN warranting further investigation.

  6. Corticosteroid Treatment Influences TA-Proteinuria and Renal Survival in IgA Nephropathy.

    Directory of Open Access Journals (Sweden)

    Cristina Sarcina

    Full Text Available The clinical course of IgA nephropathy (IgAN and its outcome are extremely variable. Proteinuria at baseline has been considered one of the most important risk factors. More recently, mean proteinuria of follow-up (time-average proteinuria: TAp was described as a stronger marker of renal survival, suggesting to consider it as a marker of disease activity and response to treatment. We evaluated predictors of renal survival in IgAN patients with different degrees of renal dysfunction and histological lesions, focusing on the role of the therapy in influencing TAp. We performed a retrospective analysis of three prospective, randomized, clinical trials enrolling 325 IgAN patients from 1989 to 2005. Patients were divided into 5 categories according to TAp. The primary endpoint of the 100% increase of serum creatinine occurred in 54 patients (16.6% and renal survival was much better in groups having lower TAp. The median follow up was 66.6 months (range 12 to 144. The primary endpoint of the 100% increase of serum creatinine occurred in 54 patients (16,6% and renal survival was much better in groups having lower TA proteinuria. At univariate analysis plasma creatinine and 24h proteinuria, systolic (SBP and diastolic (DBP blood pressure during follow-up and treatment with either steroid (CS or steroid plus azathioprine (CS+A were the main factors associated with lower TAp and renal survival. At multivariate analysis, female gender, treatment with S or S+A, lower baseline proteinuria and SBP during follow-up remained as the only variables independently influencing TAp. In conclusion, TA-proteinuria is confirmed as one of the best outcome indicators, also in patients with a severe renal insufficiency. A 6-month course of corticosteroids seems the most effective therapy to reduce TAp.

  7. The nucleation of HCl and Cl{sub 2}-based HVPE GaN on mis-oriented sapphire substrates

    Energy Technology Data Exchange (ETDEWEB)

    Bohnen, Tim; Dreumel, Gerbe W.G. van; Enckevort, Willem J.P. van; Ashraf, Hina; Jong, Aryan E.F. de; Hageman, Paul R.; Vlieg, Elias [IMM, Radboud University, Nijmegen (Netherlands); Weyher, Jan L. [Institute of High Pressure Physics, Polish Academy of Sciences, Warsaw (Poland)

    2010-07-15

    The nucleation of both classic HCl-based and novel Cl{sub 2{sup -}} based HVPE GaN on mis-oriented sapphire substrates was investigated. The use of Cl{sub 2}in HVPE increases the growth rate by a factor of 4-5 and strongly reduces the parasitic deposition, allowing for the growth of much thicker wafers than HCl-based HVPE. Morphological SEM surface studies of the HCl-based HVPE sample surface show that at 600 C a nanocrystalline layer is deposited on the sapphire. During the subsequent annealing phase, the morphology changes to a {mu}m-sized island structure. During overgrowth at 1080 C, the islands coalesce. Small voids or pinholes are then formed in between the coalescing GaN islands. These pinholes lead to numerous pits on the surface of the GaN at thicknesses of 5 {mu}m. The pits disappear during continued overgrowth and can no longer be found on the surface, when the GaN film reaches a thickness of 45 {mu}m. This particular coalescence mechanism also applies to Cl{sub 2}-based HVPE GaN on sapphire (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  8. Analisis Penentuan Variabel dari Biaya Kapal Sebagai Acuan Penentuan Subsidi untuk Kapal Perintis :Studi Kasus Maluku

    Directory of Open Access Journals (Sweden)

    Rio Jagarin Silaban

    2012-09-01

    Full Text Available Subsidi diberikan untuk menjembatani ketidak-seimbangan antara harga atau tarip yang ditetapkan produsen dengan kekuatan daya beli konsumen dikarenakan konsumen tersebut tidak dapat membayar sesuai dengan tarip yang ditetapkan. Penelitian ini dimaksudkan untuk mengkaji formula penentuan subsidi saat ini dan mengeloborasi dengan solusi alternatife. Studi dilakukan dengan  menentukan  variabel jarak, yang ada di biaya kapal perintis dan dapat dijadikan sebagai acuan penentuan  subsidi. Hasil penelitian menunjukkan bahwa penentuan subsidi saat ini  hanya ditentukan oleh variabel Jarak saja dan variabel penentu saat ini belum bisa menghitung besaran subsidi dengan lebih objektif karena ada beberapa variabel penentu lainnya yang bisa dijadikan sebagai acuan penentuan subsidi seperti GT, BHP, ABK dan Umur.

  9. Seminar dan Wokshop Jurnalistik Anak SMA “Yournalism”

    OpenAIRE

    T.R, Amal Gamasi; Nugroho, Adi; Setyabudi, Djoko

    2013-01-01

    PENDAHULUANMasyarakat Indonesia saat ini merupakan masyarakat informasi yangmenghabiskan sebagian besar waktunya dengan media komunikasi dan menggunakanteknologi informasi seperti ponsel dan komputer maupun laptop. Mereka akan mudahmelakukan pertukaran data informasi karena saat ini,mengingat konvergensi mediatidak hanya mengubah basis data dan medium yang menyalurkannya, tetapi jugasecara keseluruhan mengubah proses produksi, pengolahan, dan distribusi informasisehingga media-media seperti k...

  10. Rapid and cyclic dust accumulation during MIS 2 in Central Asia inferred from loess OSL dating and grain-size analysis.

    Science.gov (United States)

    Li, Yun; Song, Yougui; Lai, Zhongping; Han, Li; An, Zhisheng

    2016-09-02

    Due to lack of reliable proxies from the Westerlies-dominant region, the strength change of Northern Hemisphere Westerlies remains poorly understood. The aim of this study is to provide a reliable paleoclimatic proxy about the Northern Hemisphere Westerlies change. Here we report a 30.7 m thick loess section from the Ili basin directly controlled by the Westerlies. Based on optically stimulated luminescence (OSL) and high resolution grain-size records, we reconstruct the change history of the Westerlies strength during the last glacial period (mainly Marine Isotope Stages 2, MIS2), being similar with the Westerlies index recorded in the Qinghai Lake sediments. Within error limits, all ages are in stratigraphic order. We further compare the climatic records among the Ili loess, Qinghai Lake and the NGRIP, their similarity shows a good climatic coupling relationship among the Central Asia, East Asia and the North Atlantic, and the Westerlies plays a critical influence in transporting the North Atlantic signal to Central and East Asia.

  11. Electrical characterization of MIS devices using PECVD SiN{sub x}:H films for application of silicon solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jin-Su; Cho, Jun-Sik; Park, Joo-Hyung; Ahn, Seung-Kyu; Shin, Kee-Shik; Yoon, Kyung-Hoon [Korea Institute of Energy Research, Daejeon (Korea, Republic of); Yi, Jun-Sin [Sungkyunkwan University, Suwon (Korea, Republic of)

    2012-07-15

    The surface passivation of crystalline silicon solar cells using plasma enhanced chemical vapor deposition (PECVD), hydrogenated, silicon-nitride (SiN{sub x}:H) thin films has become significant due to a low-temperature, low-cost and very effective defect passivation process. Also, a good quality antireflection coating can be formed. In this work, SiN{sub x}:H thin films were deposited by varying the gas ratio R (=NH{sub 3}/SiH{sub 4}+NH{sub 3}) and were annealed by rapid thermal processing (RTP). Metal-insulator- semiconductor (MIS) devices were fabricated using SiN{sub x}:H thin films as insulator layers and they were analyzed in the temperature range of 100 - 400 K by using capacitance-voltage (C-V) and current-voltage (I-V) measurements. The annealed SiN{sub x}:H thin films were evaluated by using the electrical properties at different temperature to determine the effect of surface passivation. We achieved an energy conversion efficiency of 18.1% under one-sun standard testing conditions for large-area (156 mm x 156 mm) crystalline-silicon solar cells.

  12. BLOKIR MALWARE BERBAHAYA MELEWATI PROXY MENGGUNAKAN ROUTER PFSENSE DAN PAKET HAVP

    Directory of Open Access Journals (Sweden)

    Dedi Irawan

    2017-12-01

    Full Text Available Dilansir dari halaman Support Apple, malware adalah perangkat lunak berbahaya, yang berisi virus, worm, trojan horse, dan program lainnya yang dapat membahayakan Mac atau privasi Anda. Malware dapat diinstal saat Anda mengunduh item dari email, pesan, dan situs web. Sumber: https://support.apple.com/kb/PH25640?locale=id_ID&viewlocale=id_ID. Program ini dapat mengubah, merusak, mencari celah, dan mencuri data pribadi seseorang yang tentu sangat merugikan. Malware dapat menghasilkan saat mengunduh data melalui email, pesan, dan situs web. Salah satu perangkat yang paling banyak digunakaan saat ini adalah smartphone sebagai perangkat untuk mengakses situs web. Meskipun semua komputer sudah terinstal antivirus, harus ditambahkan lapisan perlindungan lain ke jaringan komputer, dalam hal ini HAVP bekerja dengan sangat baik.

  13. Climate, vegetation and lake development at Sokli (northern Finland) during early MIS 3 at ∼50 kyr: Revising earlier concepts on climate, glacial and vegetation dynamics in Fennoscandia during the Weichselian

    International Nuclear Information System (INIS)

    Helmens, Karin F.

    2009-08-01

    Long sediment records that register environmental changes in formerly glaciated regions such as Fennoscandia in the period preceding the Last Glacial Maximum (LGM) at ∼ 20 kyr are rare. The Weichselian history of Fennoscandia is based on the long-distance correlation of poorly dated stratigraphic fragmentary evidence and studies on glacial geomorphology. Environmental conditions during ice-free intervals have been mostly reconstructed based on low resolution palynological analysis only. Here we present the results of a detailed study of a for Fennoscandia unusually long and continuous sediment sequence that has been recovered from the Sokli basin in northern Finland. The Sokli sequence consists of tills, glacio-fluvial beds, and fluvial beds, interlayered with fossil-rich lacustrine sediments that according to multiple accelerator mass spectrometer (AMS) 14 C and optically stimulated luminescence (OSL) datings extend from the present into the Penultimate Glacial representing the last ∼130 kyr. This report focuses on the youngest Weichselian interstadial interval with ice-free conditions at Sokli dated to ∼50 kyr in the early part of Marine Isotope Stage (MIS) 3. A comprehensive environmental reconstruction is made based on multi-proxy analysis on a two meter thick laminated, lacustrine clay-silt sequence, including lithological characteristics; organic content (loss-on-ignition, LOI); plant microfossils (pollen, spores, algal and fungal remains); macrofossils of plants (e.g. seeds, moss remains) and of aquatic animals (e.g. statoblasts of Bryozoa); head-capsules of chironomids (i.e. aquatic insects); and diatoms and other siliceous microfossils (e.g. phytolits, chrysophyte stomatocysts). Additionally, geomorphic evidence and analysis of Digital Elevation Model (DEM) data are employed in the environmental reconstruction. Mean July temperatures are reconstructed by applying transfer functions to the pollen, chironomid and diatom records. The results have been

  14. Analysis of interface states and series resistance at MIS structure irradiated under {sup 60}Co {gamma}-rays

    Energy Technology Data Exchange (ETDEWEB)

    Tataroglu, A. [Department of Physics, Faculty of Arts and Sciences, Gazi University, 06500 Ankara (Turkey)], E-mail: ademt@gazi.edu.tr; Altindal, S. [Department of Physics, Faculty of Arts and Sciences, Gazi University, 06500 Ankara (Turkey)

    2007-10-11

    In this research, we investigated the effect of {sup 60}Co {gamma}-ray exposure on the electrical properties of Au/SnO{sub 2}/n-Si (MIS) structures using current-voltage (I-V) measurements. The fabricated devices were exposed to {gamma}-ray doses ranging from 0 to 300 kGy at a dose rate of 2.12 kGy h{sup -1} in water at room temperature. The density of interface states N{sub ss} as a function of E{sub c}-E{sub ss} is deduced from the forward bias I-V data for each dose by taking into account the bias dependence effective barrier height and series resistance of device at room temperature. Experimental results show that the {gamma}-irradiation gives rise to an increase in the zero bias barrier height {phi}{sub BO}, as the ideality factor n and N{sub ss} decrease with increasing radiation dose. In addition, the values of series resistance were determined using Cheung's method. The R{sub s} increases with increasing radiation dose. The results show that the main effect of the radiation is the generation of interface states with energy level within the forbidden band gap at the insulator/semiconductor interface.

  15. Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation

    Science.gov (United States)

    Meng, Guoyu; Spahich, Nicole; Kenjale, Roma; Waksman, Gabriel; St Geme, Joseph W

    2011-01-01

    Bacterial biofilms are complex microbial communities that are common in nature and are being recognized increasingly as an important determinant of bacterial virulence. However, the structural determinants of bacterial aggregation and eventual biofilm formation have been poorly defined. In Gram-negative bacteria, a major subgroup of extracellular proteins called self-associating autotransporters (SAATs) can mediate cell–cell adhesion and facilitate biofilm formation. In this study, we used the Haemophilus influenzae Hap autotransporter as a prototype SAAT to understand how bacteria associate with each other. The crystal structure of the H. influenzae HapS passenger domain (harbouring the SAAT domain) was determined to 2.2 Å by X-ray crystallography, revealing an unprecedented intercellular oligomerization mechanism for cell–cell interaction. The C-terminal SAAT domain folds into a triangular-prism-like structure that can mediate Hap–Hap dimerization and higher degrees of multimerization through its F1–F2 edge and F2 face. The intercellular multimerization can give rise to massive buried surfaces that are required for overcoming the repulsive force between cells, leading to bacterial cell–cell interaction and formation of complex microcolonies. PMID:21841773

  16. Integrasi Arsitektur Dan Manajemen Layanan Ti Untuk Pencapaian Fleksibilitas Teknologi Informasi Pada Organisasi

    OpenAIRE

    Aradea, Aradea

    2011-01-01

    Peran teknologi Informasi (TI) dalam organisasi saat ini telah mengalami pergeseran paradigma, pada awalnyaTI hanya berfokus pada otomatisasi data, pengolahan data atau manipulasi data, saat ini sudah bergeser padafungsi strategi dan layanan. Kesesuaian dan performa layanan TI dapat menjadi faktor penentu dalampencapaian tujuan dan sasaran organisasi, apabila diposisikan dan difungsikan secara tepat dan selarasdengan visi bisnis organisasi. Hal ini tentu dilakukan dengan sudut pandang yang me...

  17. INTEGRASI ARSITEKTUR DAN MANAJEMEN LAYANAN TI UNTUK PENCAPAIAN FLEKSIBILITAS TEKNOLOGI INFORMASI PADA ORGANISASI

    OpenAIRE

    Aradea, Aradea

    2012-01-01

    Peran teknologi Informasi (TI) dalam organisasi saat ini telah mengalami pergeseran paradigma, pada awalnyaTI hanya berfokus pada otomatisasi data, pengolahan data atau manipulasi data, saat ini sudah bergeser padafungsi strategi dan layanan. Kesesuaian dan performa layanan TI dapat menjadi faktor penentu dalampencapaian tujuan dan sasaran organisasi, apabila diposisikan dan difungsikan secara tepat dan selarasdengan visi bisnis organisasi. Hal ini tentu dilakukan dengan sudut pandang yang me...

  18. Hubungan Multitasking Teknologi Informasi terhadap Produktivitas Kerja (Studi Kasus: Mahasiswa ITS)

    OpenAIRE

    Marendha, Galang Arga; Susanto, Tony Dwi; Arifiana, Isrida Yul

    2016-01-01

    Pada era globalisasi saat ini cara hidup individu umumnya para remaja dan dewasa yang selalu bergerak cepat dalam mendapatkan informasi terbaru agar tidak tertinggal dari yang lain memungkinkan melakukan pekerjaan secara bersamaan. Mayoritas dari individu-individu menganggap melakukan banyak pekerjaan sekaligus dapat digunakan sebagai solusi yang tepat. Dengan kemajuan teknologi saat ini dan perilaku seperti itu, banyak sekali contoh pekerjaan yang dilakukan secara bersama-sama seperti halnya...

  19. Information Literacy of Library Science

    OpenAIRE

    Yusniah,

    2016-01-01

    Literasi Informasi telah menjadi keterampilan penting pustakawan di era global saat ini. Informasi keaksaraan bagi pustakawan tidak hanya ditandai melek dan hanya untuk membacanya. Tetapi aplikasi mempunyai nilai lebih. Pustakawan harus menjadi manajer ilmu. Pustakawan harus bergerak sesuai dengan Perubahan teknologi terus bergerak maju dan pustakawan harus mampu beradaptasi sebagai pencari dan pemberi informasi dalam bentuk apapun. Saat ini pustakawan dituntut tidak hanya perawatan terampil ...

  20. Karakteristik Gejala Dysmenorrhea dan Pengaruhnya Terhadap Aktivitas Belajar Mahasiswi S1 Keperawatan Kelas Ekstensi di Fakultas Keperawatan USU

    OpenAIRE

    Roza, Desni

    2011-01-01

    Dysmenorrhea adalah nyeri saat menstruasi yang terjadi pada perut bagian bawah yang terasa seperti kram yang dimulai saat menstruasi datang sehingga dapat menimbulkan gangguan aktivitas sehari-hari. Wanita yang mengalami dysmenorrhea mempunyai tingkat gejala nyeri yang berbeda-beda pada setiap wanita yang mengalaminya mulai dari gejala nyeri dysmenorrhea ringan sampai berat. Penelitian ini bertujuan untuk mengidentifikasi karakteristik gejala dysmenorrhea dan pengaruh terhadap aktifitas belaj...

  1. Pembuatan Media Pembelajaran Dasar Bahasa Korea Menggunakan AndEngine Berbasis Android

    OpenAIRE

    Somya, Ramos; Tjahjono, Valenciana

    2016-01-01

    . Bahasa Korea saat ini menjadi salah satu bahasa asing yang diminati untuk dipelajari oleh masyarakat Indonesia. Hal ini merupakan dampak dari masuknya Hallyu (Korean Wave) di Indonesia. Namun saat ini media pembelajaran bahasa Korea masih kurang interaktif karena keterbatasan sarana misalnya buku, dibandingkan dengan aplikasi mobile yang memiliki desain yang menarik dan fasilitas audio. Berdasarkan masalah tersebut dibuat aplikasi pembelajaran dasar bahasa Korea menggunakan AndEngine berbas...

  2. Rancang Bangun Database dan Migrasi Data Melalui teknik ORM untuk Aplikasi Dashboard Pemantauan Mytra

    OpenAIRE

    Maratul Muthi'ah

    2018-01-01

    Abstrak – Teknologi informasi dan sarana telekomunikasi berkembang sangat cepat seiring dengan kebutuhan manusia. Teknologi pada saat ini sangat memudahkan bagi kehidupan manusia. Seperti contohnya bisnis online barang/jasa yang memudahkan manusia dalam membeli barang atau menyewa jasa. Penyimpanan pada bisnis online tersebut memerlukan database, database berguna untuk menyimpan data customer, booking, serta invoice. Pada saat ini banyak sekali database yang bisa digunakan untuk membuat suatu...

  3. Paleoclimate reconstruction in the Levant region from the petrography and the geochemistry of a MIS 5 stalagmite from the Kanaan Cave, Lebanon

    Science.gov (United States)

    Nehme, C.; Verheyden, S.; Noble, S. R.; Farrant, A. R.; Delannoy, J. J.; Claeys, P.

    2015-07-01

    Lying at the transition between the temperate Mediterranean domain and subtropical deserts, the Levant is a key area to study the palaeoclimatic response over glacial-interglacial cycles. This paper presents a precisely dated last interglacial (MIS 5) stalagmite (129-84 ka) from the Kanaan Cave, Lebanon. Variations in growth rate and isotopic records indicate a warm humid phase at the onst of the last interglacial at ~129 ka that lasted until ~125 ka. A gradual shift in speleothem isotopic composition (125-122 ka) is driven mainly by the δ18O source effect of the Eastern Mediterranean surface waters during Sapropel S5. The onset of glacial inception began after ~122 ka, interrupted by a short wet pulse during Sapropel S4. Low growth rates and enriched oxygen and carbon values until ~84 ka indicate a transition to drier conditions during Northern Hemisphere glaciation.

  4. A voz da desigualdade e da miséria: reflexos discursivos no léxico da canção O meu guri

    Directory of Open Access Journals (Sweden)

    Micheline Mattedi Tomazi

    2015-08-01

    Full Text Available O objetivo principal deste estudo é analisar as ideologias e as representações mentais que se materializam na prática discursiva social da canção O meu guri, de Chico Buarque, com base na proposta teórica sociocognitiva de van Dijk (1999, 2010, 2011, 2012. Para tanto, elegemos o léxico como categoria principal de análise. Os resultados iniciais indicam que as escolhas lexicais utilizadas para compor a canção desvelam uma vida de miséria e desigualdade social vivida por uma mãe e um adolescente em conflito com a lei. Este estudo espera contribuir com uma proposta de leitura crítica que problematize questões significativas para a sociedade que, são materializadas na linguagem pelo discurso como prática social.

  5. Prospects of oil-gas content of the meso-cenozoic deposits of the middle Kura depression

    International Nuclear Information System (INIS)

    Bairamova, G.A

    2002-01-01

    Full text: Kura depression located between folded structure of the Greater and Lesser Caucasus is a typical representative of inter mountain depressions of the Alpine -Himalaya belt.Inter mountain depression is perfectly represented in geophysical fields; as a whole this zone is of high seismically,lower values of heat flow and geothermal gradient.Deep structure of inter mountain depression and in first turn, composition and genesis of their basement present a number of difficult questions that can be solved via ultra-deep drilling.With this purpose Saatly ultra-deepwellUD-1 was drilled in 1971 within Kura inter mountain depression; for the first time in the world a deep section of inter mountain depression and it's buried basement up to depth of 8323 m was reached.Differentiated block structure of basement and strict facial heterogeneity of rocks within blocks impose difficulties in constructing a cumulative geological section of rocks of buried basement.according to fragmental data of structure of buried Mesozoik basement here two contrast complexes can be distinguished in its composition:the upper-Late Cretaceous limestone's with thickness from 100 to 800 m and the lower-Mesozoik volcanogenic rocks.Vulcanite is completely drilled only in the central part of kura depression where they form a number of dome-like structures (protrusions).The discovery of Cretaceous age vulcanite in the upper part of section of Saatly ultra deep well essentially widened perspective of oil and gas reserves of central part of Kura depression and, in Cretaceous vulcanite, a new type of oil fields for Azerbaijan was found-Muradkhanly.It is located 30 km westward from Saatly ultra deep well and is confined to dome-like protrusions (Cretaceous vulcanite) of surface of Mesozoic basement, in nucleus of which the Late Cretaceous vulcanite is bedded.Oil container vulcanite in Muradkhanly field have analogous features; the reduction of porosity (11.1-4,8 vol.%) and increase of capacity density

  6. Aplikasi Sistem Pendukung Keputusan Stadium Penyakit Kanker Payudara Menggunakan Logika Fuzzy Berbasis Android

    OpenAIRE

    Rico Adrial

    2017-01-01

    Kanker payudara dapat lebih mudah diatasi saat masih stadium dini. Langkah awal dari pengobatan kanker payudara adalah dengan mendeteksi apakah gejala yang muncul pada tubuh pasien benar-benar merupakan sel kanker. Stadium kanker adalah hasil diagnosis dari fisikawan medis sehingga memudahkan pemahaman tentang penyakit pasien. Pada penelitian ini digunakan Fuzzy Logic sebagai metode yang membantu pada sistem pendukung keputusan dalam menentukan stadium kanker payudara. Saat ini banyak aplikas...

  7. Implementasi Protokol Keamanan TLS pada Aplikasi Layanan Komunikasi Suara Melalui Jaringan TCP/IP (VoIP)

    OpenAIRE

    Hariady, Ricky

    2011-01-01

    Saat ini layanan komunikasi suara melalui jaringan TCP/IP atau yang lebih dikenal dengan VoIP (Voice over IP) telah semakin banyak digunakan, namun teknologi VoIP yang ada saat ini masih rentan terhadap penyadapan ataupun pencurian data. Sementara protokol kriptografi TLS (Transport Layer Security) telah teruji dan banyak digunakan untuk mengamankan komunikasi melalui internet seperti pada layanan email dan web. Dengan mengimplementasikan protokol TLS pada sebuah aplikasi Vo...

  8. Analisis Penentuan Harga Pokok Produk Dan Penerapan Cost Plus Pricing Method Dalam Rangka Penetapan Harga Jual Pada Rumah Makan Soto Rusuk Ko' Petrus Cabang Megamas

    OpenAIRE

    Wauran, Desliane

    2016-01-01

    Dalam menjalankan USAha serta untuk mampu bertahan dalam dunia persaingan bisnis yang ketat saat ini, setiap pemilik USAha harus dapat mengambil keputusan-keputusan yang tepat salah satunya dalam menentukan harga jual. Biaya adalah nilai kas atau setara kas y ang dikeluarkan (dibebankan) untuk mendapatkan barang atau jasa, yang diharapkan dapat memberikan manfaat bagi organisasi pada saat ini maupun di masa mendatang. Tujuan penelitian ini untuk mengetahui bagaimana pemanfaatan biaya yang dik...

  9. Pemanfaatan Limbah Ranting Kayu Manis (Cinnamomun Burmanii) untuk Penciptaan Seni Kerajinan dengan Teknik Laminasi

    OpenAIRE

    Edi Eskak

    2016-01-01

    ABSTRAKLimbah ranting kayu manis (Cinnamomum burmanii) merupakan sisa kayu yang tidak ikut dikupas untuk diambil kulitnya sebagai bahan rempah-rempah. Limbah ranting ini jumlahnya cukup banyak pada saat panen kulit kayu manis. Pada saat ini limbah tersebut hanya dibuang ataupun dibakar. Penciptaan seni ini bertujuan untuk memanfaatan limbah ranting kayu manis tersebut menjadi aneka produk seni kerajinan. Metode yang digunakan yaitu eksplorasi, perancangan, dan perwujudan karya. Hasilnya berup...

  10. Analisa Interdependensi Antara Value Chain Dan Business Model Pada Industri Pengolahan Makanan

    OpenAIRE

    Kristiani, Paulina

    2015-01-01

    Latar belakang dari penelitian ini adalah dengan melihat kondisi lingkungan bisnis yang semakin ketat dan bersaing maka diperlukan model bisnis dan value chain untuk mampu bersaing dalam lingkungan industri. Tujuan penelitian ini adalah untuk melakukan analisa dan mengevaluasi pada value chain saat ini kemudian merancang pengembangan value chain berdasarkan komponen model bisnis. Teknik pengumpulan data adalah dengan menggunakan teknik wawancara dan data value chain makanan saat ini yang diam...

  11. PERBAIKAN WORKSTATION DI PT. YUSHIRO INDONESIA UNTUK MENGURANGI RESIKO KELUHAN MUSKULOSKELETAL

    OpenAIRE

    Dene Herwanto; Acep Purnama; Adi Prianto; Kristian Adi

    2016-01-01

    Salah satu pekerjaan yang masih dilakukan secara manual di PT. Yushiro Indonesia adalah penuangan bahan baku berupa cairan kimia pada saat proses pencampuran bahan. Pada saat penuangan cairan kimia tersebut, operator banyak melakukan aktivitas manual material handling yang tidak tepat dan tidak alami, sehingga timbul beberapa keluhan muskuloskeletal, seperti sakit pinggang, sakit punggung, sakit leher, dan sebagainya. Hasil penelitian menunjukkan bahwa nilai RWL dan LI yang terjadi dalam pros...

  12. Perancangan Kunci Elektrik Dengan Enkripsi Melalui Bluetooth Pada Ponsel

    OpenAIRE

    Nantan, Audi; Alaydrus, Mudrik

    2014-01-01

    Saat ini fasilitas yang disediakan oleh ponsel sangat beragam. Mulai dari telepon, SMS, kamera, music player, semuanya dijadikan satu. Tentunya ponsel juga dapat dijadikan sebagai kunci elektrik menggantikan kunci analog yang ada saat ini. Biasanya untuk membuka sebuah kunci pintu seseorang harus menggunakan sebuah anak kunci, jadi untuk mengakses banyak pintu harus memiliki banyak anak kunci yang berbeda-beda. Namun jika ponsel dijadikan sebagai kunci elektrik yang menerapkan access control ...

  13. Pornography Manifestation in Internet Media ( Content Analysis on Popular Local Porn Websites in Indonesia )

    OpenAIRE

    Sosiawan, Edwi Arif

    2009-01-01

    Pornografi yang semula hanya berupa tulisan saat ini berkembang dalam berbagai macam manifestasi seperti gambar, cerita pendek, video , film, lagu dan sebagainya. Bahkan pornografi di internet bukan lagi hanya pekerjaan orang iseng tetapi menjadi komoditi bisnis di dunia maya. Inilah yang menjadi penyebab menjamurnya situs porno di Internet. Pada sisi lain pornografi di internet juga dicap sebagai penyulut adanya kejahatan seksual, penyimpangan seksual dan bisnis seksual. Namun hingga saat in...

  14. Mis isiklik? Mis poliitiline? / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2010-01-01

    Saksa kunstniku Hannah Höchi näitus "Isiklik on poliitiline. Hannah Höch ja tema kunsti tõlgendus" Tallinna Kunstihoones 17. oktoobrini 2010, kuraator Reet Varblane. Ka näitusel eksponeeritud Martha Rosleri (USA), Guerrilla Girlsi (USA), Anna-Stina Treumundi (Eesti) töödest

  15. Short outlines of books by Estonian authors : [annotations] / Rutt Hinrikus, Janika Kronberg

    Index Scriptorium Estoniae

    Hinrikus, Rutt, 1946-

    2000-01-01

    Kaur Kender. Yuppiejumal; Hiram [Laaniste, Mari]. Mõru maik; Paul-Eerik Rummo. Luuletused; Ilona Laaman. Mulle ei meeldinud su nimi; Lehte Hainsalu. Viis minutit pärast vihma ja Kukelokuti; Maimu Berg. Ära; Kalju Kruusa. Meeleolu; Ervin Õunapuu. Eesti gootika ja Teie mälestuseks, kes iganes te olete ja kus asute; Ilmar Talve. Kevad Eestis, Kutsumatu külaline ja Kolmas kodumaa

  16. The characteristics of photo-CVD SiO{sub 2} and its application on SiC MIS UV photodetectors

    Energy Technology Data Exchange (ETDEWEB)

    Liu, C.H.; Chang, C.S.; Chang, S.J.; Su, Y.K.; Chiou, Y.Z.; Liu, S.H.; Huang, B.R

    2003-07-15

    SiO{sub 2} layers were deposited onto SiC by photo-chemical vapor deposition (photo-CVD) using deuterium (D{sub 2}) lamp as the excitation source. For the photo-SiO{sub 2} deposited 500 deg. C, interface state density (D{sub it}) was estimated to be 5.66x10{sup 11} cm{sup -2} eV{sup -1}. With an applied electric field of 4 MV cm{sup -1}, it was found that the leakage current was only 3.15x10{sup -8} A cm{sup -2} for the photo-CVD SiO{sub 2} layer prepared at 500 deg. C. It was also found that photo-SiO{sub 2} could effectively suppress dark current of SiC-based photodetectors (PDs). It was found that we could reduce dark current of SiC-based PDs by about three orders of magnitude by the insertion of a 5 nm-thick photo-CVD SiO{sub 2} film in between Indium-tin-oxide (ITO) contact and the underneath SiC. Photocurrent to dark current ratio of ITO/SiO{sub 2}/SiC MIS PDs was also found to be much larger than that of conventional ITO/SiC Schottky barrier PDs.

  17. Effect of the tunnelling oxide growth by H{sub 2}O{sub 2} oxidation on the performance of a-Si:H MIS photodiodes

    Energy Technology Data Exchange (ETDEWEB)

    Aguas, H.; Perreira, L.; Silva, R.J.C.; Fortunato, E.; Martins, R

    2004-06-15

    In this work metal-insulator-semiconductor (MIS) photodiodes with a structure: Cr/a-Si:H(n{sup +})/a-Si:H(i)/oxide/Au were studied, where the main objective was to determine the influence of the oxide layer on the performance of the devices. The results achieved show that their performance is a function of both oxide thickness and oxide density. The a-Si:H oxidation method used was the immersion in H{sub 2}O{sub 2} solution. By knowledge of the oxide growth process it was possible to fabricate photodiodes exhibiting an open circuit voltage of 0.65 V and short circuit current density under AM1.5 illumination of 11 mA/cm{sup 2}, with a response times less than 1 {mu}s for load resistance <400 {omega}, and a signal to noise ratio of 1x10{sup 7}.

  18. Diagnosis and activity assessment of immunoglobulin A nephropathy: current perspectives on noninvasive testing with aberrantly glycosylated immunoglobulin A-related biomarkers

    Directory of Open Access Journals (Sweden)

    Suzuki Y

    2014-10-01

    Full Text Available Yusuke Suzuki,1 Hitoshi Suzuki,1 Yuko Makita,1 Akiko Takahata,1 Keiko Takahashi,1 Masahiro Muto,1 Yohei Sasaki,1 Atikemu Kelimu,1 Keiichi Matsuzaki,2 Hiroyuki Yanagawa,1 Keiko Okazaki,1 Yasuhiko Tomino1 1Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, 2Kyoto University Health Service, Kyoto, Japan Abstract: Immunoglobulin (Ig A nephropathy (IgAN is the most common form of glomerular disease worldwide and is associated with a poor prognosis. Thus, development of a curative treatment and strategies for early diagnosis and treatment are urgently needed. Pathological analysis of renal biopsy is the gold standard for the diagnosis and assessment of disease activity; however, immediate and frequent assessment based on biopsy specimens is difficult. Therefore, a simple and safe alternative is desirable. On the other hand, it is now widely accepted that multi-hit steps, including production of aberrantly glycosylated serum IgA1 (first hit, and IgG or IgA autoantibodies that recognize glycan containing epitopes on glycosylated serum IgA1 (second hit and their subsequent immune complex formation (third hit and glomerular deposition (fourth hit, are required for continued progression of IgAN. Although the prognostic and predictive values of several markers have been discussed elsewhere, we recently developed a highly sensitive and specific diagnostic method by measuring serum levels of glycosylated serum IgA1 and related IgA immune complex. In addition, we confirmed a significant correlation between serum levels of these essential effector molecules and disease activity after treatment, suggesting that each can be considered as a practical surrogate marker of therapeutic effects in this slowly progressive disease. Such a noninvasive diagnostic and activity assessment method using these disease-oriented specific biomarkers may be useful in the early diagnosis of and intervention in IgAN, with

  19. Implication of urinary complement factor H in the progression of immunoglobulin A nephropathy.

    Directory of Open Access Journals (Sweden)

    Maojing Liu

    Full Text Available After activation, the complement system is involved in the pathogenesis of Immunoglobulin A nephropathy (IgAN. Complement factor H (CFH is a crucial inhibitory factor of the alternative pathway of the complement system. The study investigated the effects of urinary CFH levels on IgAN progression.A total of 351 patients with IgAN participated in this study. They were followed up for an average of 51.8 ± 26.6 months. Renal outcome was defined as a composite endpoint, that included instances of end-stage renal disease (ESRD, ≥ 50% decline in estimated glomerular filtration rate (eGFR or doubling of plasma creatinine levels. Urinary CFH levels were measured by enzyme-linked immunosorbent assay and calculated as the ratio of urinary CFH over creatinine (uCFH/uCr.In the whole cohort, uCFH/uCr values were associated with disease progression either as continuous [log(uCFH/uCr] or categorical traits (dichotomous and quartile variables after adjusting for eGFR, proteinuria, mean arterial blood pressure, histological grading and immunosuppressive therapy in the Cox proportional hazard model. Kaplan-Meier analysis showed that higher uCFH/uCr values at baseline predicted worse renal outcome during follow-up (log-rank, P < 0.001. Receiver operating characteristic curve (ROC analysis showed that log(uCFH/uCr had predictive value for renal outcome (area under curve [AUC] = 0.745, and the AUC increased to 0.805 after being incorporated into baseline eGFR and proteinuria. In subgroup analysis with eGFR ≥ 60 mL/min/1.73 m2, log(uCFH/uCr had better predictive value (AUC = 0.724, P = 0.002 for renal outcome compared to eGFR (AUC = 0.582, P = 0.259 and proteinuria (AUC = 0.615, P = 0.114.Urinary CFH levels are associated with renal function decline and increased urinary CFH levels are a risk factor for progression of IgA nephropathy.

  20. APLIKASI MOBILE INFORMASI PARIWISATA KOTA SEMARANG BERBASIS ANDROID

    Directory of Open Access Journals (Sweden)

    Tirta Indra Wibowo

    2012-10-01

    Full Text Available Kemajuan teknologi saat ini semakin pesat, salah satu yang perkembangannya cukup pesat saat ini adalah sistem operasi Android.  Aplikasi Semarang Tour adalah aplikasi mobile informasi pariwisata kota Semarang yang berbasiskan Android. Aplikasi ini menampilkan informasi objek wisata, wisata kuliner, hotel, pusat belanja, info taxi, info CCTV lalu lintas, dan peta lokasi sekitar. Dengan aplikasi Semarang Tour ini pengguna  dapat mengetahui peta wisata dan petunjuk arah  lokasi wisata dengan memanfaatkan GPS pada perangkat android. Metodelogi penelitian yang digunakan adalah model pengembangan sistem waterfall. Objek wisata dan objek pendukung pariwisata yang ada di aplikasi ini merupakan objek-objek yang direkomendasikan oleh Dinas Kebudayaan dan Pariwisata kota Semarang. Aplikasi ini diharapkan dapat menyajikan  suatu informasi yang lebih efektif dan informatif  sehingga dapat digunakan sebagai panduan oleh masyarakat saat berwisata di kota Semarang. Kata kunci: Android, aplikasi mobile, pariwisata

  1. PELATIHAN MANAJEMEN DIRI UNTUK MENINGKATKAN KEPATUHAN DIET PADA PENDERITA DIABETES MELITUS TIPE II

    Directory of Open Access Journals (Sweden)

    Kondang Budiyani

    2011-02-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui apakah pelatihan manajemen diri dapat meningkatkan kepatuhan diet pada penderita diabetes melitus tipe II. Hipotesis penelitian ini adalah ada perbedaan kepatuhan diet antara pretest dan post test. Kepatuhan diet lebih tinggi pada saat post test. Subjek penelitian sebanyak 3 orang. Penelitian ini menggunakan metode quasi experimental design dan rancangan eksperimen the one group pretest-posttest design. Analisis data menggunakan pemeriksaan visual (visual inspection. Hasil menunjukan (1 apabila dibandingkan dengan sebelum pelatihan manajemen diri maka ada peningkatan skor kepatuhan diet pada saat pelatihan manajemen diri dan sesudah pelatihan manajemen diri. Skor kepatuhan diet yang paling tinggi adalah pada saat pelatihan manajemen diri, (2 Apabila dibandingkan dengan sebelum pelatihan manajemen diri maka ada peningkatan skor manajemen diri sesudah pelatihan manajemen diri Kata kunci : kepatuhan diet, pelatihan manajemen diri, penderita diabetes melitus tipe II

  2. Kriyojenik İşlem Uygulanmış Dökme Demir Malzemelerin Mekanik Özelliklerinin İncelenmesi

    Directory of Open Access Journals (Sweden)

    İsmail Deniz Kağan DEMİR

    2017-01-01

    Full Text Available Bu çalışmada, gri dökme demir (GG20 ve sfero dökme demir (GGG40 numuneler üzerine uygulanmış olup bir grup 36 saat -80oC kriyojenik işleme tabi tutulmuş, diğer bir grup ise 12 saat –80oC de bekletilip, 12 saat oda sıcaklığında bekletilmiş ve ardından 36 saatlik çevirimli kriyojenik işleme tabi tutulmuştur. Kryojenik işlem uygulanmış ve uygulanmamış numulerin çekme test sonuçları, sertlik ölçüm değerleri ve mikroyapısal değişimleri incelenmiş ve karşılaştırılmıştır.

  3. Rembrandt in 2006: splendeur et misère van een herdenkingsjaar

    Directory of Open Access Journals (Sweden)

    E. O. G. Haitsma Mulier

    2008-01-01

    Full Text Available M. Alexander-Knotter, e.a., De 'joodse' Rembrandt. De mythe ontrafeld; S.A.C. Dudok van Heel, De jonge Rembrandt onder tijdgenoten. Godsdienst en schilderkunst in Leiden en Amsterdam; M. Roscam Abbing, Rembrandt 2006. Essays; Rembrandt 2006. New Rembrandt documents; R. van Straten, Rembrandts Leidse tijd 1606-1632; Chr. Tümpel, Rembrandt en de bijbel. Alle etsen; Ch. Vogelaar, e.a., Rembrandts landschappen; M. de. Winkel, Fashion and fancy. Dress and meaning in Rembrandt's paintings; E. Runia, e.a., Rembrandt in het Mauritshuis; G. Hoekveld-Meijer, De God van Rembrandt. Rembrandt als commentator van de godsdienst van zijn tijd; Ch. Vogelaar, e.a., Rembrandts moeder. Mythe en werkelijkheid; E. van de Wetering, e.a., Rembrandt. Zoektocht van een genie; M. Roscam Abbing, Rembrandt. Leven en werk van de grootste schilder aller tijden; A. K. Wheelock jr., e.a., Rembrandts late religieuze portretten; D. Bull, e.a., Rembrandt. Caravaggio; H. Beliën, e.a., Langs Rembrandts roem. De reputatie van een meester; F. Lammertse, e.a., Uylenburgh en zoon. Kunst en commercie van Rembrandt tot De Lairesse 1625-1675; G. Schwartz, De grote Rembrandt; A. McNeil Kettering, Rembrandts groepsportretten; M. Schapelhouman, Rembrandt en de kunst van het tekenen; B. Broos, Het Rembrandt boekRembrandt in 2006: splendeur et misère of a Year of RemembranceThe 400th anniversary of Rembrandt’s birth was celebrated with exhibitions and other activities. Compared to the previous celebration, the commercial aspects were strikingly evident. Various interpretations of Rembrandt’s work were presented; here they are considered from a historian’s point of view. To what extent did art historians incorporate historical aspects of Rembrandt’s life into their opinions? Many a book published on the occasion of an exhibition contained articles about art history but rarely a catalogue of the works on display. A few authors ventured to present historical interpretations, most of

  4. Pengaruh Intensitas Mengakses Media Sosial Adidas dan Citra Merek terhadap Keputusan Pembelian Sport Shoes Adidas di Kalangan Remaja Wanita

    OpenAIRE

    Purnama, Ayu Sri; Herieningsih, Sri Widowati; Pradekso, Tandiyo; Rakhmad, Wiwid Noor

    2016-01-01

    Sport shoes merupakan salah satu jenis sepatu yang di minati oleh masyarakat saat ini, Selain itu akhir-akhir ini salah satu jenis sport shoes yakni running shoes menjadi fashion baru dikalangan remaja di Indonesia. Namun salah satu produsen sports shoes yaitu adidas saat ini kurang diminati bila dibandingkan dengan kompetitornya hasil survey mengenai sport shoes yang digunakan dan diminati oleh remaja wanita di Indonesia menunjukkan bahwa Adidas menempati urutan ke- tiga setelah nike dan con...

  5. Perancangan Supply Chain Management Pada Sistem Pengelolaan Mice (Meetings Incentives Conferences Exhibitions) Di STMIK STIKOM Bali

    OpenAIRE

    Agustino, Dedy Panji

    2015-01-01

    Sebuah perguruan tinggi saat ini memiliki peran yang sangat penting bagi dunia pendidikan dalam mencetak lulusan-lulusan yang terampil dan siap kerja. Demikian juga dengan STIKOM Bali yang merupakan perguruan tinggi ICT di Bali yang sudah berdiri sejak 2002 dan saat ini memiliki 6000 mahasiswa dan telah meluluskan lebih dari 2000 lulusan. Sebagai perguruan tinggi yang sedang berkembang, tentu nya STIKOM Bali tidak hanya menjalankan aktifitas belajar mengajar saja, namun juga kegiatan akademis...

  6. PERAMALAN BEBAN JANGKA PENDEK PADA HARI LIBUR DI BALI MENGGUNAKAN METODE GENERALIZED REGRESSION NEURAL NETWORK (GRNN)

    OpenAIRE

    Juniar Doan Wihardono; Agus Dharma; I Made Mataram

    2016-01-01

    Peramalan beban merupakan suatu kegiatan untuk memperkirakan kondisi beban pada hari yang akan datang. Kondisi beban pada saat hari libur merupakan suatu fenomena yang sangat menarik untuk diketahui. Fenomena ini terjadi di Bali yaitu pada saat hari Raya Nyepi. Karena, kondisi beban pada hari Raya Nyepi akan mengalami penurunan yang sangat drastis. Kondisi tersebut perlu diketahui agar operasi sistem tenaga listrik dapat berjalan secara optimal. Metode peramalan beban pada penelitian ini meng...

  7. Optimasi Parameter K pada Algoritma K-nearest Neighbour untuk Klasifikasi Penyakit Diabetes Mellitus

    OpenAIRE

    Indrayanti, Indrayanti; Sugianti, Devi; Al Karomi, Adib

    2017-01-01

    Diabetes Mellitus merupakan salah satu penyakit kronis yang mematikan. Penyakit yang juga dikenal dengan nama penyakit kencing manis ini terjadi akibat kadar glukosa di dalam darah terlalu tinggi. Diabetes Mellitus banyak diteliti di banyak negara pada saat ini karena peningkatan penderita yang banyak dan sangat mengkhawatirkan. Menurut WHO saat ini lebih dari 246 juta jiwa menderita diabetes dan diperkirakan akan meningkat menjadi 380 juta jiwa pada tahun 2025 apabila tidak dilakukan penang...

  8. De la literatura misógina medieval a la igualdad de oportunidades entre hombres y mujeres. Descripción de una unidad didáctica para 3º de la ESO

    OpenAIRE

    Bataller Català, Alexandre

    2009-01-01

    Se explica y comenta los contenidos y secuenciación de una unidad didáctica que contiene como tema transversal la igualdad de oportunidades entre homes y mujeres, preparada para la asignatura de "Valencià. Llengua i literatura" para el curso de 3º de la ESO (que hemos publicado dentro de un proyecto editorial, Ediciones SM, 2007). Los contenidos literarios, tanto teóricos como prácticos, tratan tanto de la obra más celebrada de temática misógina del siglo XV, la novela en verso l'Spill, escri...

  9. THERMAL-HYDRAULIC ANALYSIS OF SMR WITH NATURALLY CIRCULATING PRIMARY SYSTEM DURING LOSS OF FEED WATER ACCIDENT

    Directory of Open Access Journals (Sweden)

    Susyadi Susyadi

    2016-09-01

    ABSTRAK Reaktor daya kecil modular (SMR memiliki beberapa keunggulan dibanding reaktor daya besar konvensional. Dengan disain yang lebih sederhana dan terintegrasi, penerapan hukum alamiah untuk sistem keselamatannya dan biaya modal yang rendah, reaktor ini sangat cocok untuk dibangun di Indonesia. Salah satunya disain SMR yang sedang dikembangkan menerapkan gaya penggerak alami untuk sistim pendingin primernya. Dengan disain seperti itu, adalah sangat penting untuk memahami implikasinya terhadap aspek keselamatan pada seluruh kondisi operasi. Salah satu yang perlu diinvestigasi adalah kecelakaan kehilangan air umpan (LoFW. Pada studi ini, dilakukan analisis kinerja thermal hidrolik SMR yang menggunakan sistim pendinginan primer sirkulasi alam saat kecelakaan LoFW. Tujuannya adalah untuk menginvestigasi karakteristik aliran sistem primer saat kecelakaan LoFW dan untuk memastikan apakah aliran sirkulasi alam cukup untuk memindahkan panas dari teras guna menjaga kondisi tetap aman selama kecelakaan tersebut. Metoda yang digunakan adalah dengan merepresentasikan sistem reaktor ke dalam model-model generik program RELAP5 dan melakukan simulasi numerik. Hasil perhitungan menunjukkan bahwa setelah kejadian pemicu dan trip reaktor, pada sisi primer laju alirnya berfluktuasi secara signifikan dan temperatur pendinginnya menurun secara bertahap sedangkan  pada sisi sekunder kondisi uap berubah menjadi uap jenuh. Laju alir turun dari ~711 kg/detik menjadi ~263 kg/detik sebelum kembali naik lagi pada t=~46 detik. Saat laju alir di titik terendah, temperatur pusat bahan bakar dan fluida pendingin adalah sekitar  ~565 K dan  ~554 K, yang menujukkan bahwa temperatur bahan bakar masih jauh di bawah batas disain dan temperatur fluidanya juga berada di bawah titik saturasi. Keadaan ini menunjukkan bahwa saat transien kedua parameter utama termohidrolik reaktor tetap dalam kondisi yang dapat diterima sehingga dapat disimpulkan  bahwa saat  kecelakaan kehilangan air umpan, SMR

  10. Castigo, gestão do risco e da miséria: Novos discursos da prisão na contemporaneidade

    Directory of Open Access Journals (Sweden)

    Rafael de Albuquerque Figueiró

    Full Text Available Resumo Com a falência do discurso ressocializador que marcou a modernidade, a contemporaneidade traz à tona outros discursos em torno do encarceramento, produzindo mudanças nos sistemas jurídico-penais. Nesse sentido, e partindo do referencial teórico-metodológico da análise institucional, o presente artigo realiza uma análise das funções ocupadas pela prisão na contemporaneidade com relação ao público alvo desses equipamentos. Assim, a partir de nossa inserção em uma unidade prisional do sistema prisional do Rio Grande do Norte, realizamos uma observação participante da rotina de trabalho dos agentes penitenciários. Como resultados, apresentamos três analisadores para pensar a prisão: os híbridos prisão-abrigo, prisão-albergue e prisão-masmorra. Tais analisadores revelam que a prisão na contemporaneidade adquire um caráter de equipamento híbrido, ao articular as funções de punição, detenção provisória e gestão da miséria, colocando em xeque qualquer intenção reabilitadora.

  11. SIKAP PENONTON DALAM PROGRAM TELEVISI INDONESIA SAAT INI

    Directory of Open Access Journals (Sweden)

    Rahmat Edi Irawan

    2016-09-01

    Full Text Available The study in this paper is motivated increasing reports or complaints against television delivered to the Indonesian Broadcasting Commission (KPI. This paper aims to look at how the shift from a passive audience or spectators into active audience or spectators give feedback on television shows that they receive, which is now starting to look also at the television audience in Indonesia. Methodology or study in this paper uses literature, to see how the exercise of some theories of mass communication, particularly with regard to the impact of television on the audience. Conclusions or the results of the study for this paper is to begin the shift to a passive audience active audience in the television industry in Indonesia today. If in the past, many obstacles, such as a repressive regime, not the choice of programs and television stations as well as the lack of regulation and the regulator has ever television audience in Indonesia passive. While today, empowering the audience various media and efforts made KPI caused his condition has changed, the audience began to be active. It was indicated by increasing their critical stance, with the umber of impressions made complaints on violation of regulations either through KPIs or other mass media.

  12. Artikel Kehormatan: Saat Rakyat Bicara: Demokrasi dan Kesejahteraan

    Directory of Open Access Journals (Sweden)

    Bagir Manan

    2014-04-01

    Full Text Available Abstrak Secara tradisional, kesejahteraan adalah suatu kepercayaan bahwa kesejahteraan sosial merupakan tanggung jawab dari masyarakat dan tanggung jawab ini harus dipenuhi oleh pemerintah yang dilaksanakan dalam bentuk negara atau sistem pemerintahan. Demokrasi masih dipandang sebagai sistem yang paling sesuai dalam rangka tercapainya kesejahteraan sosial karena demokrasi memberikan jalan bagi rakyat untuk berbicara. Namun, pada praktiknya demokrasi oleh masyarakat awam kerapkali diartikan sebagai pemerintah yang sebenarnya lebih menekankan kepada demokrasi politik. Artikel ini akan memperlihatkan bagaimana kesejahteraan sosial dianalisis secara akurat dari pemikiran mengenai demokrasi sosial yang berjalan beriringan dengan model demokrasi konsensus sebagai dasar fundamental dalam menghadapi peristiwa negara dan pemerintahan. Abstract Traditionally, Welfarism is the belief that social well-being is the responsibility of a community which could only be realized through state or governmental management. It is still believed that Democracy is the most proper system in achieving social welfare, since it permits the people of a country to speak. In practice, however, Democracy is only understood as a system that gives the governmental rights to the majority of the people. This article, thus, will argue that social wel fare is more precisely analyzed through the notion of Social-Democracy, which goes hand-in-hand with the consensus model of Democracy as a fundamental base in carrying out state and governmental affairs.

  13. PENGARUH VARIASI SUHU PADA PROSES SELF TEMPERING DAN VARIASI WAKTU TAHAN PADA PROSES TEMPERING TERHADAP SIFAT MEKANIS BAJA AISI 4140

    Directory of Open Access Journals (Sweden)

    Sunardi Sunardi

    2016-07-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui sifat mekanis pada baja AISI 4140 dengan proses tempering dengan variasi waktu tahan dan variasi suhu pada proses self tempering. Material terlebih dahulu dipanaskan pada suhu 850°C, di tahan dengan waktu 14 dan 28 menit, media pendinginan adalah Oli SAE 20. Pada proses tempering baja dipanaskan kembali dengan suhu 200°C di tahan dengan waktu 30 dan 120 menit. Sedangkan untuk proses self tempering, baja di panaskan pada suhu 850°C di tahan dengan waktu 14 dan 28 menit kemudian didinginkan, suhu yang harus dicapai pada pendinginan adalah 200°C, 400°C dan 600°C. Proses tempering dengan variasi waktu tahan mempunyai nilai kekerasan terbesar 50,1 HRC dengan waktu tahan 120 menit, sedangkan nilai kekerasan terbesar pada proses self tempering dengan variasi suhu adalah 29,68 HRC pada suhu 200°C. Nilai ketangguhan terbesar pada saat proses tempering adalah 0,341 (J/mm2 dengan waktu tahan 120 menit, sedangkan pada saat proses self tempering ketangguhan terbesar pada suhu 600°C dengan nilai 0,375 (J/mm2. Laju korosi terbesar pada saat tempering adalah 0,055 (mpy dengan waktu tahan 30 menit, sedangkan pada saat proses self tempering laju korosi terbesar pada suhu 400°C dengan nilai 0,0388 (mpy. 

  14. Sığır Etinde Su Tutma Kapasitesi ve Serbest Su Oranı Değişimi Üzerine bir Araştırma

    Directory of Open Access Journals (Sweden)

    Aydın Öztan

    2015-02-01

    Full Text Available Kesimden sonra ette pH değişimi, etin serbest su oranı ve su tutma kapasitesinin belirlenmesinde en önemli kriterdir. Bu araştırmada; 12 adet sığır karkasında M. Trapezius kasında kesimde, kesimden 1 saat 24 saat ve 48 saat sonra pH ölçümleri yapılmış, kompressium yöntemi ile serbest su oranı ve üç farklı yöntemle su tutma kapasitesi saptanmıştır. Pres yönteminde; süzgeç kağıtlarında toplam su alanı (T ve et alanı (Ev ek scanner ile taranmış, bilgisayarda alan ölçümleri yapılmıştır. PH-değeri bakımından zaman ve hayvan değişkenleri önemli bulunmuştur. Ette serbest su oranı rigor mortis döneminde (24 saat artmış, daha sonra düşmeye başlamıştır. Örneklerde su tutma kapasitesi kesimden başlayarak olgunlaşma periyodunda rigor mortis sonuna kadar düşmüş, daha sonra yükselmeye başlamıştır.

  15. Cuadros en movimiento: la pintura en el cine: Relaciones intermediales en La hora de los valientes [Mercero 1998] y Te doy mis ojos [Bollaín 2003

    Directory of Open Access Journals (Sweden)

    Esther Gimeno Ugalde

    2011-12-01

    Full Text Available The objective of this article is to study the relationship between cinema and painting from an intermedial perspective by analysing two Spanish films: La hora de los valientes (Antonio Mercero 1998 and Te doy mis ojos (Icíar Bollaín 2003. We intend to compare how the respective directors use painting to construct and enrich the cinematographic story and to analyse what narrative and artistic role the paintings play in the filmic text. The study of the two films will serve to illustrate our initial hypothesis, that painting is used not only for artistic and narrative purposes, but also to make the spectator a witness of a twofold drama: the individual and the collective. The exchange of looks which permeates the diegesis places painting to the forefront, whilst determining the interpretation of the filmic textBasándonos en un enfoque teórico intermedial, el presente artículo tiene como objeto estudiar las relaciones entre cine y pintura a partir de dos películas españolas: La hora de los valientes [Antonio Mercero 1998] y Te doy mis ojos [Icíar Bollaín 2003]. Nos proponemos cotejar cómo los respectivos directores introducen la pintura para construir y enriquecer el relato cinematográfico y analizar qué función narrativa y estética cumplen los cuadros en el texto fílmico. El estudio de ambos filmes nos servirá para demostrar nuestra hipótesis inicial: la pintura se emplea no solo con fines estéticos y narrativos, sino también para convertir al espectador en testigo de un doble drama, el individual y el colectivo. El juego de miradas que atraviesa la diégesis sitúa a la pintura en un primer plano, a la vez que determina la lectura del texto fílmico

  16. Study of the effect of passivation layers on capacitance of AlGaN/GaN heterostructures

    Directory of Open Access Journals (Sweden)

    Kira L. Enisherlova

    2016-12-01

    Full Text Available MOCVD grown AlGaN/GaN heterostructures on sapphire and silicon substrates have been studied. The capacity–voltage characteristic have been measured in the 200 Hz–1 MHz frequency range with a planar position of mercury and second probe on the specimen surface. The shape of the typical C–V curves for the heterostructures with upper undoped i-AlGaN and i-GaN layers 1,5–2,5 nm in thickness have been analyzed. The appearance of a typical peak on the C–V curves upon a change from the depletion region to the accumulation region has been registered in some structures with an i-GaN layer thickness of 5 nm and more at low frequencies (f<50–200 kHz. The height of this peak increased with a reduction of frequency. It has been found experimentally that the frequency at which the peak is registered can depend on the dislocation density in heterostructures. Possible explanation of the peak formation and band diagram transformation in these structures under an applied electric field have been presented. We show that the application of a Si3N4 passivation layer results in the formation of additional positive charge.

  17. {sup 60}Co {gamma} irradiation effects on the current-voltage (I-V) characteristics of Al/SiO{sub 2}/p-Si (MIS) Schottky diodes

    Energy Technology Data Exchange (ETDEWEB)

    Tataroglu, A. [Department of Physics, Faculty of Arts and Sciences, Gazi University 06500, Ankara (Turkey)]. E-mail: ademt@gazi.edu.tr; Altindal, S. [Department of Physics, Faculty of Arts and Sciences, Gazi University 06500, Ankara (Turkey); Buelbuel, M.M. [Department of Physics, Faculty of Arts and Sciences, Gazi University 06500, Ankara (Turkey)

    2006-12-01

    It is well known that the exposure of any semiconductor surfaces to the {sup 60}Co {gamma}-ray irradiation causes electrically active defects. To investigate the effect of {gamma}-ray irradiation dose on the electrical characteristics of metal-insulator-semiconductor (MIS) Schottky diodes, the fabricated devices were exposed to {gamma} radiation at a dose of 2.12 kGy/h. The total dose range was from 0 to 450 kGy at room temperature. The density of interface states N {sub ss} as a function of E {sub ss}-E {sub v}, the values of series resistance R {sub s} and the bias dependence of the effective barrier height {phi} {sub e} for each dose were obtained from the forward bias I-V characteristics. Experimental results show that the {gamma}-irradiation gives rise to an increase in the zero bias barrier height {phi} {sub BO}, as the ideality factor n, R {sub s} and N {sub ss} decreases with increasing radiation dose.

  18. MODEL PENGEMBANGAN APLIKASI PEMBAYARAN ANGSURAN PINJAMAN ONLINE MENGGUNAKAN PHP-MYSQL DENGAN METODE OBJECT ORIENTED PROGRAMMING

    Directory of Open Access Journals (Sweden)

    Whisnumurti Adhiwibowo

    2017-12-01

    Full Text Available Sistem pembayaran angsuran berbasis web pada suatu koperasi merupakan sistem yang bersifat dinamis dalam arti akan selalu berkembang dan kompleks. Metode Pemrograman prosedural memiliki kelemahan saat mengembangkan aplikasi yang kompleks. Ketika terjadi permasalahan, penanganannya menjadi sulit karena porgram terdiri dari banyak fungsi dan pada saat mengubah suatu fungsi akan mengubah fungsi fungsi yang lain. Tidak hanya saat terjadi permasalahan, suatu sistem berbasis pemrograman prosedural juga susah apabila akan dikembangkan. Oleh karena itu di pendang perlu untuk mengembangan Sistem dengan metode object Oriented Programming (OOP, merupakan metode pemrograman berorientasi obyek.  Sistem yang di bangun dengan metode ini terdiri dari banyak obyek yang saling berhubungan. Perancangan yang dipakai menggunakan Unified Modeling Language (UML, suatu metodologi untuk mengembangkan sistem dengan pendekatan OOP. Pengembangan Sistem ini menggunakan Hypertext Prepocessor (PHP. Metode pengembangan sistem yang digunakan adalah Waterfall. Hasil dari penelitian ini adalah terbentuknya sistem pembayaran transaksi berbasis web dengan metode OOP, sehingga dapat lebih mudah pemeliharaan dan pengembangannya

  19. Perancangan dan Implementasi Kontroler PID Gain Scheduling untuk Gerakan Lateral Way-to-Way Point pada UAV Quadcopter

    Directory of Open Access Journals (Sweden)

    Tri Awan Nusa Putra

    2013-09-01

    Full Text Available Quadcopter diharapkan dapat bergerak secara lincah dan efektif menyusuri lintasan horisontal. Berdasar hukum fisisnya, gerak lateral dapat terjadi karena adanya daya angkat dan terjadinya perubahan sudut dari quadcopter tersebut. Mengacu pada hal tersebut, sudut-sudut gerak pada quadcopterakan menjadi parameter untuk gerak maju atau menyamping yang secara langsung juga berpengaruh pada gerak vertikal. Pada saat proses hoveratau melayang, adalah saat yang paling riskan pada quadcopter. Sehinga pengaturan hover dari quadcopter menjadi prioritas pada riset ini, karena apabila terjadi kesalahan hoverakan menyebabkan perubahan gerak terhadap sumbu X, Y maupun Z. Pada tugas akhir ini digunakan kontroler PID dan metode gainscheduling dengan nilai parameter penguatan yang diperoleh secara eksperimental untuk pengaturan gerak lateral menyusuri lintasan. Apabila menggunakan metode PID biasa, maka diperoleh penurunan ketinggian yang drastis hingga 50% dari total ketinggian quadcopter, namun apabila menggunakan metode PID GainScheduling, pada simulasi hanya terjadi penurunan ketinggian sebesar 0,35% dan saat implementasi mengalami sekitar 10% dari total ketinggian yang dicapai.

  20. Perancangan Sistem Pakar Pendiagnosis Kerusakan Laptop di "Dinar Comp" Berbasis Web dengan PHP dan MySQL

    Directory of Open Access Journals (Sweden)

    Wandri Okki Saputra

    2014-01-01

    Full Text Available Saat sekarang ini laptop sudah menjadi kebutuhan di kalangan pelajar, mahasiswa, karyawan dan profesi lainya. Suatu saat laptop tersebut akan mengalami kerusakan dan diperlukan seorang pakar untuk mendiagnosis kerusakan tersebut. Aplikasi sistem pakar merupakan salah satu aplikasi untuk diagnosis kerusakan laptop seperti kemampuan seorang pakar. Dengan adanya sistem pakar, dapat membantu pengguna untuk bisa mendiagnosis kerusakan laptop tanpa harus di diagnosis oleh pakar. Dalam perancangan aplikasi, metode yang digunakan adalah metode waterfall. Metode ini sangat tepat dalam pembuatan aplikasi seperti ini karena mempunyai alur yang memungkinkan perancang untuk mengevaluasi aplikasi tanpa harus mengubah dari dasar. Sedangkan tahapan dalam pembuatan aplikasi ini menggunakan beberapa tahap yaitu studi pustaka dan bimbingan, pengambilan data dan analisa (wawancara, pengamatan dan berkas informasi, perancangan, pembuatan sistem dan terakhir implementasi. Berdasarkan hasil pengujian alpha dan betha, aplikasi yang dibangun sudah berjalan cukup maksimal, tetapi tidak menutup kemungkinan dapat terjadi kesalahan dan kekurangan pada saat aplikasi digunakan.