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Cervical Cancer Stage IB

Science.gov (United States)

... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IB Add to My Pictures View /Download : ... 1613x1200 View Download Large: 3225x2400 View Download Title: Cervical Cancer Stage IB Description: Stage IB1 and IB2 cervical ...
Treatment of cancer of cervix stages IB1 and IB2 in the Hospital Calderon Guardia (2000-2003)

International Nuclear Information System (INIS)

Saenz, Oscar; Picans, Serafin

2004-01-01

The types of treatment applied in patients with stages of cancer of cervix IB1 and IB2, your evolution and prognosis were determined. Different methods of treatment were compared. It was a prospective descriptive and observational study of the patients of Servicio de Ginecologia Oncologica of the Hospital Calderon Guardia, San Jose, Costa Rica. It was carried out from August 2000 to November 2002. The study included all female patients with proved histological diagnosis of cervical cancer IB1 and IB2. All of them had pre-operative studies: plate of thorax, abdomen ultrasound, computerized axial tomography of pelvis and abdomen, at least received primary treatment (surgery) and the following monitoring. The statistical analysis was realized with chi-square evidences, through epi-info software. Of 24 patients only 19 got complete information. It was found a 22% of patients with positives adenopatias to level of histological study with a ganglionic compromise of 32% in general form, a 36% in the stages IB1 and a 25% in stages IB2. Of all the patients that presented ganglionic metastasis illness, did not get to show with the computerized axial tomography and it is concluded that TAC is a bad method for detection of the microscopic metastasis illness, or at least to 2 cm. None of the patients in stages IB1 presented relapse data in the observed period, founding a 100% of survival to 24 months. The patients in stages IB2 presented relapses, with a 75% of survival [es
Fully-Implicit Navier-Stokes (FIN-S)

Science.gov (United States)

Kirk, Benjamin S.

2010-01-01

FIN-S is a SUPG finite element code for flow problems under active development at NASA Lyndon B. Johnson Space Center and within PECOS: a) The code is built on top of the libMesh parallel, adaptive finite element library. b) The initial implementation of the code targeted supersonic/hypersonic laminar calorically perfect gas flows & conjugate heat transfer. c) Initial extension to thermochemical nonequilibrium about 9 months ago. d) The technologies in FIN-S have been enhanced through a strongly collaborative research effort with Sandia National Labs.
Invasive cervical carcinoma (stage IB-IIB): assessment with MR imaging

International Nuclear Information System (INIS)

Sironi, S.; Del Maschio, A.; Belloni, C.; Taccagni, L.

1990-01-01

In patients with cervical carcinoma the selection of the optimal therapy depends on the precise preoperative assessment of the extent of disease. Currently, decisions regarding the management of these patients are made on the basis of clinical (FIGO) staging that has 50% mean error rate. To investigate the value of MR imaging in staging patients with invasive cervical cancer, we performed 25 MR examinations on 23 patients with histologic diagnosis of cervical cancer. All patients were clinically considered as having stage IB or IIB disease and underwent radical hysterectomy, providing specimens for pathologic correlation. The overall accuracy of MR imaging in staging cervical carcinoma (stage IB-IIB) was 78.1%. MR imaging seems to be the most reliable preoperative modality for staging invasive cervical cancer
Carcinoma of the uterine cervix stage IB and early stage II. Prognostic value of the histological tumor regression after initial brachytherapy

International Nuclear Information System (INIS)

Calais, G.; Le Floch, O.; Chauvet, B.; Reynaud-Bougnoux, A.; Bougnoux, P.

1989-01-01

In our center limited centro pelvic invasive carcinomas of the uterine cervix (less than 4 cm) are treated with brachytherapy and surgery. With these therapeutic modalities no residual carcinoma was observed for 80% of the patients. The purpose of this study was to evaluate our results with this treatment, and to evaluate the prognostic value of the pathological status of the cervix. From 1976 to 1987 we have treated 115 patients with these modalities. Staging system used was the FIGO classification modified for Stage II (divided in early Stage II and late Stage II). Patients were Stage IB (70 cases) and early Stage II (45 cases); 60 Gy were delivered with utero vaginal brachytherapy before any treatment. Six weeks later a radical hysterectomy with pelvic lymphadenectomy was performed. Twenty-one patients with positive nodes received a pelvic radiotherapy (45 to 55 Gy). Local control rate was 97% (100% for Stage IB and 93% for early Stage II). Uncorrected 10-year actuarial survival rate was 96% for Stage IB and 80% for early Stage II patients. No treatment failure was observed for Stage IB patients. Ninety-two patients (80%) had no residual carcinoma in the cervix (group 1) and 23 patients (20%) had a residual tumor (group 2). The sterilization rate of the cervix was 87% for Stage IB tumors versus 69% for early Stage II, and was 82% for N- patients versus 68% for N+ patients. Ten year actuarial survival rate was 92% for group 1 and 78% for group 2 (p = 0, 1). Grade 3 complications rate was 6%. We conclude that brachytherapy + surgery is a safe treatment for limited centro pelvic carcinomas of the uterine cervix (especially Stage IB) and that pathological status of the cervix after brachytherapy is not a prognostic factor
Poor Prognostic Factors in Patients with Malignant Pleural Mesothelioma Classified as Pathological Stage IB According to the Eighth Edition TNM Classification.

Science.gov (United States)

Takuwa, Teruhisa; Hashimoto, Masaki; Kuroda, Ayumi; Nakamura, Akifumi; Nakamichi, Toru; Fukuda, Akihiro; Matsumoto, Seiji; Kondo, Nobuyuki; Hasegawa, Seiki

2018-04-03

The change in TNM classification of malignant pleural mesothelioma (MPM) between the seventh and eighth edition classifications has resulted in the downstaging of many advanced-stage patients into pathological stage IB. Many mesotheliomas without lymph node metastasis have been classified as stage IB in the eighth edition classification. Stage IB mesotheliomas comprised a heterogeneous group with different prognosis. It is necessary to clarify the prognostic factors in this group. Between September 2009 and August 2016, a total of 89 patients with MPM underwent curative intent surgery [pleurectomy decortication n = 57 (64.1%), extrapleural pneumonectomy n = 32 (35.9%)] at our institution. Of these, 40 were reclassified as stage IB according to the eighth edition TNM classification. Independent unfavorable prognostic factors were identified by univariate analyses using the log-rank test and Cox proportional hazards regression models. Three independent significant factors were identified that indicated an unfavorable prognosis: a nonepithelioid subtype, lymphovascular invasion, and preoperative forced expiratory volume in 1 s (FEV1) < 2000 ml. Patients with no, one, and two of these risk factors showed 3-year overall survival probabilities of 94.7, 62.5, and 0%, respectively. The 3-year survival of patients with one factor did not differ significantly from that of patients with stage III MPM, whereas that of patients with two factors was significantly shorter (p = 0.015). Independent poor prognostic factors for patients with stage IB MPM patients, allowing subgroups with poorer and more favorable prognoses to be identified. This should help personalize decisions on adjuvant chemotherapy.
Lymphangiogenesis in cervical cancer evaluated by expression of the VEGF-C gene in clinical stage IB-IIIB

Directory of Open Access Journals (Sweden)

Magdalena Franc

2015-02-01

Full Text Available Introduction : The aim of the present study was to evaluate the profile of VEGF-C gene expression in particular stages of cervical cancer (IB-IIIB and to estimate the correlation between VEGF-C mRNA quantity profile and clinical stage. Material and methods : Material for molecular analysis consisted of cervical cancer tissue specimens collected from 38 women (10, 15, 13 cases were classified as IB, IIB and IIIB, respectively. The control group was composed of normal cervical tissues collected from 10 women who underwent hysterectomy for non-oncological reasons. The number of VEGF-C mRNA copies in particular groups was estimated by the reverse transcription quantitative polymerase chain reaction (RT-qPCR method. Results: In the control group the average number of mRNA copies was 134 ± 36 (median: 106, in a group with stage IB it was 16 077 ± 7090 (median: 580, for stage IIB – 35 019 ± 8945 (median: 40 870. The highest number of mRNA VEGF-C copies was derived in a group of patients with cervical cancer of stage IIIB. The average quantity was 56 155 ± 12 470, whereas median 55 981. A statistically significantly higher level of VEGF-C gene expression was disclosed in cervical cancer specimens with stage IIB and IIIB than in the control group. In stage IIIB, the VEGF-C gene expression was significantly higher than in specimens derived from individuals in stage IB. Conclusions : In squamous cell carcinoma of the uterine cervix of stage IB-IIIB genes involved in lymphangiogenesis, especially VEGF-C , are expressed, which expression increases as the clinical stage of cervical cancer is higher.
Novel 14-nm Scallop-Shaped FinFETs (S-FinFETs) on Bulk-Si Substrate

OpenAIRE

Xu, Weijia; Yin, Huaxiang; Ma, Xiaolong; Hong, Peizhen; Xu, Miao; Meng, Lingkuan

2015-01-01

In this study, novel p-type scallop-shaped fin field-effect transistors (S-FinFETs) are fabricated using an all-last high-k/metal gate (HKMG) process on bulk-silicon (Si) substrates for the first time. In combination with the structure advantage of conventional Si nanowires, the proposed S-FinFETs provide better electrostatic integrity in the channels than normal bulk-Si FinFETs or tri-gate devices with rectangular or trapezoidal fins. It is due to formation of quasi-surrounding gate electrod...
Invasive cervical carcinoma (Stages IB-IIB)

International Nuclear Information System (INIS)

Sironi, S.; Zanello, A.; Rodighiero, M.G.; Vanzulli, A.; Del Maschio, A.; Taccagni, G.L.; Belloni, C.

1991-01-01

In the patients with invasive cervical carcinoma, the accurate assessment of parametrial invasion greatly affects the therapeutic choice between surgery and radiation therapy. As a matter of fact, surgery is usually performed only in the patients with carcinoma confined to the cervix, whereas those with parametrial involvement, or more advanced stages, are treated with radiation therapy. This prospective study was aimed at investigating the comparative adequecy of CT and MR imaging in assessing parametrial status in the patients with invasive cervical cancer. Twenty-one consecutive patients, with histologic diagnosis of cervical carcinoma, were investigated. All of them were clinically considered as having invasive cervical cancer (FIGO stage IB-IIB) and subsequently underwent surgery. In all cases, detailed histology of the parametrium was obtained. Pathological data were compared with CT and MR findings in all cases. As for assessing parametrial involvement by cancer, CT had 62% accuracy, 63% sensitivity, and 60% specificity, versus MR imaging 81% accuracy, 69% sensitivity, and 80% specificify. Therefore, MR imaging appears to be superior to CT in assessing the parametrial status of patients with invasive cervical carcinoma; the method yields valuable information for treatment planning
Effectiveness of postoperative radiation therapy in stage IB cervical cancer with residual disease

International Nuclear Information System (INIS)

Herman, J.; Perez-Tamayo, C.; Komaki, R.U.; Terada, K.; Roberts, J.A.; Morley, G.W.; Greenberg, M.; Mattingly, R.; Hopkins, M.

1987-01-01

Twenty-one patients with stage IB cervical cancer were treated with radical hysterectomy, pelvic lymph node dissection, and pelvic radiation therapy to approximately 5,090 rad. Patients were divided into two groups: group I, nine patients with involved parametria or positive margins at surgery; group II, 12 patients with metastatic pelvic lymph nodes. Patients in group I had an actuarial survival of 40% at 5 years and 20% at 10 years; patients in group II had an actuarial survival of 67% at 5 and 10 years (.01 < P < .05). The overall actuarial survival was 55% at 5 years and 43% at 10 years. Thus, patients with stage IB disease and involved parametrium or surgical margins do poorly. Alternative forms of therapy should be considered when this disease picture is clinically suspected preoperatively
Adjuvant Chemotherapy Improves the Probability of Freedom From Recurrence in Patients With Resected Stage IB Lung Adenocarcinoma.

Science.gov (United States)

Hung, Jung-Jyh; Wu, Yu-Chung; Chou, Teh-Ying; Jeng, Wen-Juei; Yeh, Yi-Chen; Hsu, Wen-Hu

2016-04-01

The benefit of adjuvant chemotherapy remains controversial for patients with stage IB non-small-cell lung cancer (NSCLC). This study investigated the effect of adjuvant chemotherapy and the predictors of benefit from adjuvant chemotherapy in patients with stage IB lung adenocarcinoma. A total of 243 patients with completely resected pathologic stage IB lung adenocarcinoma were included in the study. Predictors of the benefits of improved overall survival (OS) or probability of freedom from recurrence (FFR) from platinum-based adjuvant chemotherapy in patients with resected stage IB lung adenocarcinoma were investigated. Among the 243 patients, 70 (28.8%) had received platinum-based doublet adjuvant chemotherapy. A micropapillary/solid-predominant pattern (versus an acinar/papillary-predominant pattern) was a significantly worse prognostic factor for probability of FFR (p = 0.033). Although adjuvant chemotherapy (versus surgical intervention alone) was not a significant prognostic factor for OS (p = 0.303), it was a significant prognostic factor for a better probability of FFR (p = 0.029) on multivariate analysis. In propensity-score-matched pairs, there was no significant difference in OS between patients who received adjuvant chemotherapy and those who did not (p = 0.386). Patients who received adjuvant chemotherapy had a significantly better probability of FFR than those who did not (p = 0.043). For patients with a predominantly micropapillary/solid pattern, adjuvant chemotherapy (p = 0.033) was a significant prognostic factor for a better probability of FFR on multivariate analysis. Adjuvant chemotherapy is a favorable prognostic factor for the probability of FFR in patients with stage IB lung adenocarcinoma, particularly in those with a micropapillary/solid-predominant pattern. Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
Advanced microchannel heat exchanger with S-shaped fins

International Nuclear Information System (INIS)

Tsuzuki, Nobuyoshi; Ishizuka, Takao; Kato, Yasuyoshi; Nikitin, Konstantin

2009-01-01

Fin shape effects on thermal-hydraulic characteristics were studied for a Microchannel Heat Exchanger (MCHE) with S-shaped fins using 3D-CFD and changing the fin parameters: fin angle, overlapping length, fin width, fin length, and edge roundness. The fin angle effect on the pressure drop is consistent with the equation obtained experimentally by Weisbach for a circular bent tube: the pressure drop in the S-shaped fin configuration results from bent flow. The overlap of fins with those located immediately downstream at the offset position provides a guide wing effect that reduces the pressure drop remarkably. The overlap was changed by changing the fin radial position and arc length. The pressure drop was minimized when the downstream fins are placed in the middle of the bent flow channels formed by the fins upstream, which differs from Ito's configuration obtained from experiments with a single bent duct. Regarding arc length, the pressure drop is minimized at the standard overlapping length, which was formed to have the longest arc without a change in channel width. Shorter arc lengths from the optimum value by 30 and 50%, respectively, give 2.4 and 4.6% decreases in the heat transfer rate and 17 and 13% increases in the pressure drop. Thinner fins show better thermal-hydraulic performance for fin widths of 0.2-0.8 mm. However, the pressure drop reduced by the longer fin and heat transfer rate was also reduced. Rounded fins with 0.1 mm radius increased the pressure drop by about 30% compared with that of the fin designed with no roundness. (author)
High temperature mechanical properties on multi stage blazed fin body with ultra fine off-set fin for compact heat exchanger

International Nuclear Information System (INIS)

Ishiyama, Shintaro; Muto, Yasushi

2003-01-01

Three stage blazed plate fin body with ultra fine off-set fin (thickness x height x pitch x off-set pitch = 0.22 mm x 1.2 mm x 1.6 mm x 5 mm) for 600 MWt High Temperature Gas Cooled Reactor Gas Turbin (HTGR-GT) system was fabricated and tested on its high temperature mechanical properties and the following results were derived. (1) tested body shows almost the same strength an fatigue behavior of SUS 304 as main structural material at elevated temperatures up to 873 K, (2) static and fatigue fracture mainly occurred at ultra fine off-set and (3) high temperature strength and fatigue life are improved by blazing technique to double side walls of the fin by Ni blaze material. (author)
Post-Infectious IBS (IBS-PI)

Science.gov (United States)

... for IBS Signs and Symptoms Overview Recognizing Symptoms Diagnosis of IBS Pain in IBS IBS with Constipation Constipated Diarrhea IBS ... for IBS Signs and Symptoms Overview Recognizing Symptoms Diagnosis of IBS Pain in IBS IBS with Constipation Constipated Diarrhea IBS ...
Adjuvant postoperative radiation therapy following simple hysterectomy and radical hysterectomy in stage IB cancer of the cervix: Analysis of risk factors and patterns of failure

International Nuclear Information System (INIS)

Kim, R.Y.; Weppelmann, B.; Sanford, S.P.; Salter, M.M.; Brascho, D.J.

1986-01-01

Between 1969 and 1980, 242 cases of stage IB cancer of the cervix were referred to the department of radiation oncology for curative radiation therapy. In 186 cases treatment was with radiation therapy alone. In 56 cases treatment included adjuvant postoperative radiation therapy; a minimum follow-up of 5 years has been carried out in this group. In 17 cases radiation therapy followed a simple hysterectomy for an unexpected stage IB cancer of the cervix. In 39 cases radiation therapy was given after a radical hysterectomy for stage IB cancer of the cervix because of positive margins and/or positive pelvic lymph nodes
Srinagarind Hospital experience in concurrent chemoradiation for 100 patients with stage IB2 to IVA uterine cervical cancer

International Nuclear Information System (INIS)

Tangsiriwatthana, T.; Chumworathayi, B.; Yuenyao, P.; Luanratanakorn, S.; Pattamadilok, J.

2007-01-01

The aim of this study was to determine responses, acute adverse effects, and survival outcomes of women with stage IB2 to IVA treated with weekly cisplatin concurrent with pelvic irradiation at Srinagarind Hospital. The medical records of 100 women with cervical cancer stage IB2 to IVA who were treated with weekly cisplatin 40 mg/m 2 concurrent with pelvic radiotherapy at Srinagarind Hospital between January 2003 and June 2006 were reviewed and analyzed. During the study period, 100 women were eligible for analysis, with a mean age of 46 years (range 24-60 years). Distribution according to International Federation of Gynecology and Obstetrics (FIGO) staging was IB2 1.0%, IIB 47.0%, IIIB 51.0%, and IVA 1.0%, respectively. A total of 86 patients received five or more cycles of weekly cisplatin. Grade 3 and 4 hematologic toxicities were found in 6.0%. The overall response rate was 97.0%. Complete response was achieved in 86 patients (86.0%) and partial response in 11 patients (11.0%). Stable disease was found in 1 patient (1.0%) but no progressive disease was found. Progression-free survival and overall survival rate were 69.6% and 96.1%, respectively. Weekly cisplatin (40 mg/m 2 ) concurrent with pelvic irradiation for locally advanced cervical cancer was effective with acceptable toxicity in Thai women. (author)
The effects of age on treatment and outcomes in women with stages IB1-IIB cervical cancer.

Science.gov (United States)

Roque, Dario R; Cronin, Beth; Robison, Katina; Lopes, Vrishali; Rizack, Tina; Dizon, Don S

2013-10-01

Age may affect the treatment choice and subsequent outcome in elderly patients with cervical cancer. Given the potential for cure with either surgery or chemoradiation in early stage disease, we aimed to determine whether a patient's age influenced treatment received and the ensuing outcome. We identified 303 patients with stages IB1-IIB cervical carcinoma treated at our institution between 2000 and 2010, who were divided into two groups based on age at time of diagnosis: stage at presentation, and grade. Women ≥ 65 years of age were less likely to receive primary surgical management (p=0.03). Age did not influence disease-specific or all-cause mortality. However, women over 65 years who underwent primary surgery were at significantly increased risk of all-cause mortality compared to younger women (HR 6.53, 95% CI: 2.57-16.6). Age appears to influence treatment received by patients with stages IB1-IIB cervical cancer. Although there was no difference in cancer-specific mortality stratified by type of treatment received, surgery was associated with a 6.5-fold increased risk of all-cause mortality among women 65 years or over. © 2013.
Preoperatively Assessable Clinical and Pathological Risk Factors for Parametrial Involvement in Surgically Treated FIGO Stage IB-IIA Cervical Cancer.

Science.gov (United States)

Canaz, Emel; Ozyurek, Eser Sefik; Erdem, Baki; Aldikactioglu Talmac, Merve; Yildiz Ozaydin, Ipek; Akbayir, Ozgur; Numanoglu, Ceyhun; Ulker, Volkan

2017-10-01

Determining the risk factors associated with parametrial involvement (PMI) is of paramount importance to decrease the multimodality treatment in early-stage cervical cancer. We investigated the preoperatively assessable clinical and pathological risk factors associated with PMI in surgically treated stage IB1-IIA2 cervical cancer. A retrospective cohort study of women underwent Querleu-Morrow type C hysterectomy for cervical cancer stage IB1-IIA2 from 2001 to 2015. All patients underwent clinical staging examination under anesthesia by the same gynecological oncologists during the study period. Evaluated variables were age, menopausal status, body mass index, smoking status, FIGO (International Federation of Obstetrics and Gynecology) stage, clinically measured maximal tumor diameter, clinical presentation (exophytic or endophytic tumor), histological type, tumor grade, lymphovascular space invasion, clinical and pathological vaginal invasion, and uterine body involvement. Endophytic clinical presentation was defined for ulcerative tumors and barrel-shaped morphology. Two-dimensional transvaginal ultrasonography was used to measure tumor dimensions. Of 127 eligible women, 37 (29.1%) had PMI. On univariate analysis, endophytic clinical presentation (P = 0.01), larger tumor size (P PMI. In multivariate analysis endophytic clinical presentation (odds ratio, 11.34; 95% confidence interval, 1.34-95.85; P = 0.02) and larger tumor size (odds ratio, 32.31; 95% confidence interval, 2.46-423.83; P = 0.008) were the independent risk factors for PMI. Threshold of 31 mm in tumor size predicted PMI with 71% sensitivity and 75% specificity. We identified 18 patients with tumor size of more than 30 mm and endophytic presentation; 14 (77.7%) of these had PMI. Endophytic clinical presentation and larger clinical tumor size (>3 cm) are independent risk factors for PMI in stage IB-IIA cervical cancer. Approximately 78% of the patients with a tumor size of more than 3 cm and endophytic
Medications (for IBS)

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新加坡FinTech生态系统建设及其启示%Singapore’s FinTech Ecological System Construction and Its Enlightenment

Institute of Scientific and Technical Information of China (English)

钟鸣长

2016-01-01

Since the financial crisis, the integration of finance and technology has become a new trend in global economic development, and become a hot issue in the political, business, and academic attention. Singapore government maps out a strategy and introduces a series of policies to build FinTech ecosystem, such as financial support, establishing FinTech SUB, and implementing regulatory sandbox. Thus, Singapore will transform the existing financial system, construct the FinTech hub, and become an intelligent country of S&T and intelligent financial center. However, Internet finance in China is still at the stage of FinTech1.0 currently, which appears to be fast, slant, and disordered. So it is urgent to be transformed and upgraded. Meanwhile, we should not only be fully aware of the necessity and urgency of FinTech ecosystem development, clarify the relation between Internet financial and FinTech, but also we should learn from Singapore’s advanced experience to develop the FinTech ecosystem in all aspects, for example, setting up specialized management institutions, determining specific development goals, providing financial support, promoting “Regulatory Sandbox”, mobilizing domestic and international market resources, and exerting the role of the government, market, and enterprises.%金融危机以来，金融与科技的融合成为全球经济发展的一股新潮流和趋势，成为政、商、学界关注的热点话题。新加坡从资金支持、搭建创业加速平台、推行监管沙盒等方面推出了打造FinTech生态系统的组合拳，旨在改造现有金融体系、建设FinTech枢纽中心，立志成为世界智慧科技大国和智慧金融中心。中国互联网金融目前总体上还处于FinTech1.0阶段，呈现一种“快、偏、乱”的现象，亟需转型与升级。因此，我们不仅要充分意识到FinTech产业发展的必要性和紧迫性，厘清互联网金融与Fin

Randomized study of preoperative radiation and surgery or irradiation alone in the treatment of Stage IB and IIA carcinoma of the uterine cervix

International Nuclear Information System (INIS)

Perez, C.A.; Camel, H.M.; Kao, M.S.; Askin, F.

1980-01-01

A prospective randomized study in selected patients with Stage IB and IIA carcinoma of the uterine cervix was carried out. Patients were randomized to be treated with 1) irradiation alone consisting of 1000 rad whole pelvis, additional 4000 rads to the parametria with a step wedge midline block, and two intracavitary insertions for 7500 mgh; and 2) irradiation and surgery, consisting of 2000 rad whole pelvis irradiation, one intracavitary insertion for 5000 to 6000 mgh followed in two to six weeks later by a radical hysterectomy with pelvic lymphadenectomy. The five-year, tumor-free actuarial survival for Stage IB patients treated with radiation was 87% and with preoperative radiation and surgery 82%. In Stage IIA, the actuarial five-year survival NED was 57% for the irradiation alone group and 71% for the patients treated with preoperative radiation and radical hysterectomy. Major complications of therapy were slightly higher in the patients trated with radiation alone (9.4%, consisting of one recto-vaginal fistula and one vesico-vaginal fistula and a combined recto-vesico-vaginal fistula in another patient). In the preoperative radiation group, only two ureteral strictures (4.1%) were noted. The present study shows no significant difference in therapeutic results or morbidity for invasive carcinoma of the uterine cervix Stage IB or IIA treated with irradiation alone or combined with a radical hysterectomy
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Risk model in stage IB1-IIB cervical cancer with positive node after radical hysterectomy

Directory of Open Access Journals (Sweden)

Chen Z

2016-05-01

Full Text Available Zhilan Chen,1,2,* Kecheng Huang,1,* Zhiyong Lu,1,3 Song Deng,1,4 Jiaqiang Xiong,1 Jia Huang,1 Xiong Li,5 Fangxu Tang,1 Zhihao Wang,6 Haiying Sun,1 Lin Wang,1 Shasha Zhou,1 Xiaoli Wang,1 Yao Jia,1 Ting Hu,1 Juan Gui,7 Dongyi Wan,1 Ding Ma,1 Shuang Li,1 Shixuan Wang11Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Techonology, Wuhan, 2Department of Obstetrics and Gynecology, Wuhan General Hospital of Guangzhou Military Command, Wuhan, 3Hubei Key Laboratory of Embryonic Stem Cell Research, Tai-He Hospital, Hubei University of Medicine, Shiyan, Hubei, 4Department of Obstetrics and Gynecology, University Hospital of Hubei University for Nationalities, Enshi, Hubei, 5Department of Obstetrics and Gynecology, Wuhan Central Hospital, Wuhan, 6Department of Pathology and Pathophysiology, Key Laboratory of Ministry of Education of China for Neurological Disorders, Huazhong University of Science and Techonology, Wuhan, 7Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University, Wuhan, People’s Republic of China*These authors contributed equally to this workAbstract: The purpose of this study was to identify risk factors in patients with surgically treated node-positive IB1-IIB cervical cancer and to establish a risk model for disease-free survival (DFS and overall survival (OS. A total of 170 patients who underwent radical hysterectomy and bilateral pelvic lymphadenectomy as primary treatment for node-positive International Federation of Gynaecology and Obstetrics (FIGO stage IB1-IIB cervical cancer from January 2002 to December 2008 were retrospectively analyzed. Five published risk models were evaluated in this population. The variables, including common iliac lymph node metastasis and parametrial invasion, were independent predictors of outcome in a multivariate analysis using a Cox regression model. Three distinct prognostic groups (low, intermediate, and high risk
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Therapeutic Results of Surgery and Radiation Therapy in Younger Patients with Stage IB Cervical Cancer

International Nuclear Information System (INIS)

Huh, Gil Cha; Yang, Kwang Mo; Suh, Hyun Suk; Kim, Yong Bong; Lee, Eung Soo; Park, Sung Kwan

1995-01-01

Purpose : To evaluate the prognostic importance of age in patients with Stage IB cervical cancer, we examined the relationship between age and survival in patients. Methods and materials : Retrospective analysis was performed on 107 patients were treated with surgery followed by postoperative radiotherapy or radiation alone between October 1983 and August 1993 and 28 patients with Stage IB cervical cancer treated with surgery alone between January 1989 and August 1993 at Inje University Seoul Paik Hospital. Patients ranged in age from 26 to 74 (median 48) and were followed for a median period of 39 months. Patients were divided into two groups; Group A comprising 32 patients with≤age 40 and Group B comprising 75 patients with>age 40. Both Group A and Group B patients were comparable with respect to all covariables studied. Results : The overall 5-year survival and the disease free 5-year survival for the 107 patients studied were 85.2% and 82.1% respectively. The overall survival for group A and Group B was 92% and 83%, respectively(p>0.05). The disease free 5-year survival for Group A and Group B was 82.3% and 82.6%, respectively(p>0.05). There was no difference in both local and distant failure in Group A and Group B. Conclusion : On the basis of the this analysis it is concluded that age alone is a poor indicator of prognosis and should not be used as an indication for adjuvant treatment
Medications (for IBS)

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Introduction to IBS

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... Day Art of IBS Gallery Contact Us Search Introduction to IBS Details What is IBS? Last Updated: ... tax-deductible donation. Make Donation What is IBS? Introduction to IBS Symptoms of IBS What Causes IBS? ...
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Risk strata-based therapy and outcome in stage Ib-IIa carcinoma cervix: single-centre ten-year experience.

Science.gov (United States)

Kundargi, Rajshekar S; Guruprasad, B; Rathod, Praveen Shankar; Shakuntala, Pn; Shobha, K; Pallavi, Vr; Uma Devi, K; Bafna, Ud

2013-01-01

To review the outcome of stage (Ib, IIa), cervical cancer patients were primarily treated with radical hysterectomy and risk-based postoperative therapy. Between January 2001 and December 2011, 601 cases underwent surgery followed by tailored therapy. Patients were classified into low risk (pelvic lymph node negative, tumour less than 4 cm, no evidence of lympho-vascular invasion, less than one-third of thickness of surgical stoma involved), intermediate risk (positive lympho-vascular space invasion, tumour size more than 4 cm, and deep invasion of cervical stroma), and high risk (pelvic lymph node involved, positive parametrial, or vaginal margins) groups. Postoperative adju-vant therapy in the form of radiotherapy alone to those with intermediate risk and chemo-radiotherapy to those with high risk was given to patients. The median follow-up was 60 months. The majority of patients had intermediate risk. The overall event-free survival (EFS) at five years was 74.37%, with EFS of 86.5% in those from the low-risk group, 73% in those from the intermediate-risk group, and 64% in those from the high-risk group. In conclusion, risk strata-based adjuvant postoperative therapy is able to provide a favourable outcome in patients with stage Ib-IIa cervical cancer with a nearly 11% improvement in survival compared with historical control.
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Los animales representados en el arte rupestre de la Península Ibérica. Frecuencias de los mismos

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Jesús Altuna

2002-01-01

Full Text Available Se trata de recuentos de los animales figurados en el arte parietal paleolítico de la Península Ibérica, considerados tanto en su conjunto y comparados con el de Perigord y el Pirineos Francés, como en las diversas regiones de la misma Península, incluidos los sitios protugueses. Tanto la primera comparación como la consideración por separado de los animales representados en las diversas regiones peninsulares, muestra diferencias notables. Por fin se recuentan las figuras animales de todos los sitios del País Vasco, tanto peninsular como continental.
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A biorobotic model of the sunfish pectoral fin for investigations of fin sensorimotor control

Energy Technology Data Exchange (ETDEWEB)

Phelan, Chris; Tangorra, James [Department of Mechanical Engineering, Drexel University, Philadelphia, PA 19104 (United States); Lauder, George [Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138 (United States); Hale, Melina, E-mail: tangorra@coe.drexel.ed [Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637 (United States)

2010-09-15

A comprehensive understanding of the control of flexible fins is fundamental to engineering underwater vehicles that perform like fish, since it is the fins that produce forces which control the fish's motion. However, little is known about the fin's sensory system or about how fish use sensory information to modulate the fin and to control propulsive forces. As part of a research program that involves neuromechanical and behavioral studies of the sunfish pectoral fin, a biorobotic model of the pectoral fin and of the fin's sensorimotor system was developed and used to investigate relationships between sensory information, fin ray motions and propulsive forces. This robotic fin is able to generate the motions and forces of the biological fin during steady swimming and turn maneuvers, and is instrumented with a relatively small set of sensors that represent the biological lateral line and receptors hypothesized to exist intrinsic to the pectoral fin. Results support the idea that fin ray curvature, and the pressure in the flow along the wall that represents the fish body, capture time-varying characteristics of the magnitude and direction of the force created throughout a fin beat. However, none of the sensor modalities alone are sufficient to predict the propulsive force. Knowledge of the time-varying force vector with sufficient detail for the closed-loop control of fin ray motion will result from the integration of characteristics of many sensor modalities.
Streptococcus sanguinis Class Ib Ribonucleotide Reductase

Science.gov (United States)

Makhlynets, Olga; Boal, Amie K.; Rhodes, DeLacy V.; Kitten, Todd; Rosenzweig, Amy C.; Stubbe, JoAnne

2014-01-01

Streptococcus sanguinis is a causative agent of infective endocarditis. Deletion of SsaB, a manganese transporter, drastically reduces S. sanguinis virulence. Many pathogenic organisms require class Ib ribonucleotide reductase (RNR) to catalyze the conversion of nucleotides to deoxynucleotides under aerobic conditions, and recent studies demonstrate that this enzyme uses a dimanganese-tyrosyl radical (MnIII2-Y•) cofactor in vivo. The proteins required for S. sanguinis ribonucleotide reduction (NrdE and NrdF, α and β subunits of RNR; NrdH and TrxR, a glutaredoxin-like thioredoxin and a thioredoxin reductase; and NrdI, a flavodoxin essential for assembly of the RNR metallo-cofactor) have been identified and characterized. Apo-NrdF with FeII and O2 can self-assemble a diferric-tyrosyl radical (FeIII2-Y•) cofactor (1.2 Y•/β2) and with the help of NrdI can assemble a MnIII2-Y• cofactor (0.9 Y•/β2). The activity of RNR with its endogenous reductants, NrdH and TrxR, is 5,000 and 1,500 units/mg for the Mn- and Fe-NrdFs (Fe-loaded NrdF), respectively. X-ray structures of S. sanguinis NrdIox and MnII2-NrdF are reported and provide a possible rationale for the weak affinity (2.9 μm) between them. These streptococcal proteins form a structurally distinct subclass relative to other Ib proteins with unique features likely important in cluster assembly, including a long and negatively charged loop near the NrdI flavin and a bulky residue (Thr) at a constriction in the oxidant channel to the NrdI interface. These studies set the stage for identifying the active form of S. sanguinis class Ib RNR in an animal model for infective endocarditis and establishing whether the manganese requirement for pathogenesis is associated with RNR. PMID:24381172
Flexibility of Supply Chain in Industrialised Building System (IBS

Directory of Open Access Journals (Sweden)

Kassim U.

2014-01-01

Full Text Available It is irrefutable that the construction industry is in need of a highly technological construction method or system for the simple aim of giving it a push it deserves. In Malaysia this technologically enhanced method is known as the Indutrialised Building System (IBS. Concerted efforts have been made for the past decade by various responsible parties especially by the government. Therefore, the IBS ‘Road Map’ 2003–2010 was introduced and now continues with the IBS ‘road map’ 2011-2015. However, its performance is still at its infancy, which target is only at an initial stage. This study seeks to identify and analyse the factor of the IBS’ system’s supply chain flexibility as a factor on the success of the system itself. It has been a suspicion that there exists a condition and situation where the supply chain is too rigid and is not flexible in fulfilling the needs and demands of the IBS development in Malaysia. This inflexible situation has brought about a broad range of problems and has stood in the way of the development of the industrialised building system, despite it being introduced since 1964, or 49 years ago. Flexibility in the IBS supply chain is very important and is associated with other industries like transportation, manufacturing industry, and others. Up until now, we have yet to discover any special studies related to the flexibility in the IBS supply chain in this country. Responding to this challenge, this research is hoped to be able to provide sufficient feedback to the solution to the IBS supply chain flexibility issue. The researcher is confident that the poor system flow of supply chain has impeded the advancement of the Industrialised Building System that has long been open to debate.
Medications (for IBS)

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Fin Ray Stiffness and Fin Morphology Control Ribbon-Fin-Based Propulsion.

Science.gov (United States)

Liu, Hanlin; Taylor, Bevan; Curet, Oscar M

2017-06-01

Ribbon-fin-based propulsion has rich locomotor capabilities that can enhance the mobility and performance of underwater vehicles navigating in complex environments. Bony fishes using this type of propulsion send one or multiple traveling waves along an elongated fin with the actuation of highly flexible rays that are interconnected by an elastic membrane. In this work, we study how the use of flexible rays and different morphology can affect the performance of ribbon-fin propulsion. We developed a physical model composed of 15 rays that are interconnected with an elastic membrane. We tested four different ray flexural stiffness and four aspect ratios. The robotic model was tested in a low-turbulence flume under two flow conditions ([Formula: see text] wavelength/s). In two experimental sets, we measured fin kinematics, net surge forces, and power consumption. Using these data, we perform a thrust and power analysis of the undulating fin. We present the thrust coefficient, power coefficient, and propulsive efficiency. We find that the thrust generation was linear with the enclosed area swept by the fin, and square of the relative velocity between the incoming flow and traveling wave. The thrust coefficient levels off around 0.5. In addition, for our parameter range, we find that the power consumption scales by the cube of the effective tangential velocity of the rays [Formula: see text] (A is the amplitude of the ray oscillating motion, and [Formula: see text] is the angular velocity). We show that a decay in stiffness decreases both thrust production and power consumption. However, for rays with high flexural stiffness, the difference in thrust compared with rigid rays is minimal. Moreover, our results show that flexible rays can improve the propulsive efficiency compared with a rigid counterpart. Finally, we find that the morphology of ribbon fin affects its propulsive efficiency. For the aspect ratio considered in our experiments, [Formula: see text] was the most
Medications (for IBS)

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Retrospective case-control study of surgical treatment of stage IB-IIA cervical carcinomas after neoadjuvant radiotherapy

International Nuclear Information System (INIS)

Cigriejiene, V. M.; Kajenas, S.; Balnys, M.; Mikuckaite, L.

2004-01-01

To evaluate if preoperative radiotherapy influences course of operation (radical hysterectomy and lymphadenectomy) and postoperative period in series of stage IB-IIA cervical carcinomas. Retrospective comparative study was performed. During the study we analyzed 101 case histories of patients who underwent radical type II hysterectomy with lymphadenectomy in Kaunas University of Medicine Hospital and Kaunas Hospital of Oncology between 1995 and 2002. Mean operation time was shorter, hemoglobin and hematocrit values after operation were better, stay in hospital was longer, demand for narcotic analgetics was bigger, function of ovaries was maintained more rarely (p 0.05). In our study, preoperative radiotherapy did not seem to complicate course of radical hysterectomy. (author)
Preoperative radium therapy and radical hysterectomy in the treatment of cervical cancer stage IB, IIA, and initial IIB

International Nuclear Information System (INIS)

Salum, Resalla; Lopes, Edison R.; Souza, Maria A.H. de

1995-01-01

Patients with IB, IIa and in initial IIb cervical cancer were randomized for combined therapy, consisting of one or two radium insertion followed by Wertheim Meigs operation performed 40 days later. We look for the early and late complications of the treatment, residual cancer after radiotherapy and survival without recurrence. The project begin in 1965 and ended in 1986. All the operations were done by one of the investigators and 116 patients were analysed. The age ranged from 21 to 75 years with an average of 4.18 years. During the operations 31 (26.72%) patients needed 1.500 cc or greater amount of blood transfusion and we have 3 iliac veins lesions. Managing the ureters, we do our best to leave the posterior fascia as intact as possible. Post operative complications ranged from minor (fever, localised pelvic infections, temporary popliteal nerve paralysis) to evisceration (3 patients) deep venous thrombosis (3 patients) and two early urinary fistulas. Late complications were seen in patients submitted to sequential teletherapy irradiation. One uretrovaginal fistula occurred 10 month after treatment, another one, 7 years later and the third one 24 years later. One patient develop hydronefrosis and enterocolite after 7.000 rads of teletherapy and another one rectovaginal fistula 13 years after initial therapy. The shortening of the vagina making impossible the intercourse was seen in 7 patients. By the histological examination, the cervix was sterilized in 73.3 % of the patients. Residual cancer was found according the original size of the tumour and the stage of the disease. Studying different combinations between the existence of residual cervical cancer with positive or negative limphnodes and making a correlation with survival, we found the critical points is to have positive cervix and [positive lymphonodes. The five years survival (life table methodology) for stage 1 lesion was 96%; stage II, 67%. At ten years survival was slighted different. With positive
Medications (for IBS)

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Full Text Available ... of constipation. Laxatives should be used under the supervision of a physician. Read more about laxatives. Bulking ... medications intended for specific use under a doctor’s supervision. Read more about newer IBS medications. Summary The ...
Medications (for IBS)

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topIb, a phylogenetic hallmark gene of Thaumarchaeota encodes a functional eukaryote-like topoisomerase IB.

Science.gov (United States)

Dahmane, Narimane; Gadelle, Danièle; Delmas, Stéphane; Criscuolo, Alexis; Eberhard, Stephan; Desnoues, Nicole; Collin, Sylvie; Zhang, Hongliang; Pommier, Yves; Forterre, Patrick; Sezonov, Guennadi

2016-04-07

Type IB DNA topoisomerases can eliminate torsional stresses produced during replication and transcription. These enzymes are found in all eukaryotes and a short version is present in some bacteria and viruses. Among prokaryotes, the long eukaryotic version is only observed in archaea of the phylum Thaumarchaeota. However, the activities and the roles of these topoisomerases have remained an open question. Here, we demonstrate that all available thaumarchaeal genomes contain a topoisomerase IB gene that defines a monophyletic group closely related to the eukaryotic enzymes. We show that the topIB gene is expressed in the model thaumarchaeon Nitrososphaera viennensis and we purified the recombinant enzyme from the uncultivated thaumarchaeon Candidatus Caldiarchaeum subterraneum. This enzyme is active in vitro at high temperature, making it the first thermophilic topoisomerase IB characterized so far. We have compared this archaeal type IB enzyme to its human mitochondrial and nuclear counterparts. The archaeal enzyme relaxes both negatively and positively supercoiled DNA like the eukaryotic enzymes. However, its pattern of DNA cleavage specificity is different and it is resistant to camptothecins (CPTs) and non-CPT Top1 inhibitors, LMP744 and lamellarin D. This newly described thermostable topoisomerases IB should be a promising new model for evolutionary, mechanistic and structural studies. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
Medications (for IBS)

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La República Federal de Alemania ante el fin de las dictaduras ibéricas (1974-1976): miradas entrecruzadas

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Sanz Díaz, Carlos

2012-01-01

El papel protagonista de la República Federal de Alemania, por medio principalmente de su gobierno, partidos y fundaciones políticas, y sindicatos, en las transiciones ibéricas ha sido puesto de manifiesto desde los primeros estudios sobre la dimensión internacional de los cambios de régimen político en Portugal y España en 1974-1975. Este artículo pretende contribuir al conocimiento del «factor alemán» en las transiciones ibéricas subrayando la percepción que se tenía desde Bonn de la peníns...
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Full Text Available ... treatment of IBS symptoms is not linked to depression, but rather likely to effects on the brain ... whenever a health problem arises requiring an expert’s care. © Copyright 1998-2018 International Foundation for Functional Gastrointestinal ...
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Molecular Characterization and Growth Association of Two Apolipoprotein A-Ib Genes in Common Carp (Cyprinus carpio).

Science.gov (United States)

Wang, Xinhua; Yu, Xiaomu; Tong, Jingou

2016-09-16

Apolipoprotein A-I (ApoA-I) is functionally involved in the transportation and metabolism of lipids in vertebrates. In this study, two isoforms of apoA-Ib in common carp (Cyprinus carpio L.) were characterized. Sequence comparison and phylogenetic analysis showed that C. carpio ApoA-Ib is relatively conserved within cyprinid fishes. During embryonic development, C. carpio apoA-Ib was first expressed at the stage of multi-cells, and the highest mRNA level was observed at the stage of optic vesicle. A ubiquitous expression pattern was detected in various tissues with extreme predominance in the liver. Significantly different expression levels were observed between light and heavy body weight groups and also in the compensatory growth test. Seventeen and eight single-nucleotide polymorphisms (SNPs) were identified in matured mRNA of the C. carpio apoA-Ib.1 and apoA-Ib.2, respectively. Two of these SNPs (apoA-Ib.2-g.183A>T and apoA-Ib.2-g.1753C>T) were significantly associated with body weight and body length in two populations of common carp. These results indicate that apoA-Ib may play an important role in the modulation of growth and development in common carp.
The brachytherapy vaginal cuff boost in patients with cervix cancer IB1-IB2 that have been treated with surgery plus pelvic radiotherapy in ION SOLCA, Guayaquil Ecuador from November 1 to October 2002

International Nuclear Information System (INIS)

Gamboa, Eugenia; Falquez, Roberto

2003-01-01

To determine if the additional vaginal cuff irradiation is necessary or not in patients with cervix cancer, stages IB 1- IB 2, that has been treated previously with radical hysterectomies and pelvic radiotherapy, to get better local control and global survival versus presence of complications. We studied 54 patients from Radiation Oncology Department of ION SOLCA Guayaquil Ecuador, with cervix cancer stages IB1 - IB2, that have been treated with surgery plus pelvic radiotherapy plus or not brachytherapy. They have been divides into two arms, group one included surgery plus Rx T (radiotherapy) plus BxT (Brachytherapy), and group two included those patients with surgery plus external RxT alone. We studied, aged, histologic type, surgery type, doses and techniques of teletherapy and brachytherapy and we analyzed the presence of complications. Conclusions: The brachytherapy vaginal cuff boost in patients with cervix cancer IB1-IB2 that have been treated with surgery plus pelvic radiotherapy is not useful to get better local control and global survival in some patients carefully chosen without desfavorable factors, because this therapy represent and increase in the complication. (The author)
Methylmercury in dried shark fins and shark fin soup from American restaurants.

Science.gov (United States)

Nalluri, Deepthi; Baumann, Zofia; Abercrombie, Debra L; Chapman, Demian D; Hammerschmidt, Chad R; Fisher, Nicholas S

2014-10-15

Consumption of meat from large predatory sharks exposes human consumers to high levels of toxic monomethylmercury (MMHg). There also have been claims that shark fins, and hence the Asian delicacy shark fin soup, contain harmful levels of neurotoxic chemicals in combination with MMHg, although concentrations of MMHg in shark fins are unknown. We measured MMHg in dried, unprocessed fins (n=50) of 13 shark species that occur in the international trade of dried shark fins as well as 50 samples of shark fin soup prepared by restaurants from around the United States. Concentrations of MMHg in fins ranged from 9 to 1720 ng/g dry wt. MMHg in shark fin soup ranged from sharks such as hammerheads (Sphyrna spp.). Consumption of a 240 mL bowl of shark fin soup containing the average concentration of MMHg (4.6 ng/mL) would result in a dose of 1.1 μg MMHg, which is 16% of the U.S. EPA's reference dose (0.1 μg MMHg per 1 kg per day in adults) of 7.4 μg per day for a 74 kg person. If consumed, the soup containing the highest measured MMHg concentration would exceed the reference dose by 17%. While shark fin soup represents a potentially important source of MMHg to human consumers, other seafood products, particularly the flesh of apex marine predators, contain much higher MMHg concentrations and can result in substantially greater exposures of this contaminant for people. Copyright © 2014 Elsevier B.V. All rights reserved.
IBS SURVEY 2010: DRIVERS, BARRIERS AND CRITICAL SUCCESS FACTORS IN ADOPTING INDUSTRIALISED BUILDING SYSTEM (IBS CONSTRUCTION BY G7 CONTRACTORS IN MALAYSIA

Directory of Open Access Journals (Sweden)

KAMARUL ANUAR MOHAMAD KAMAR

2014-08-01

Full Text Available The industrialised building system (IBS survey has become an essential tool for ensuring the IBS Roadmap (2003 to 2010 meets its goals and target. As part of the process review survey, it also records the trend achievement of Malaysia in the usage of IBS in the building construction industry. The first and second IBS surveys were published in 2003 and 2005, respectively. Afterward, the IBS Roadmap’s midterm review was conducted. The third and the most recent IBS surveys were conducted in 2008 and 2010, respectively. This paper aims to highlight a part of the IBS survey report in 2010, which has been conducted to measure the drivers, barriers and the critical success factors of G7 contractors in adopting IBS construction. G7 is a Construction Industry Development Board contractor grade that can apply tender without limit. The importance of this paper is that it guides the policy and implementation strategy of IBS by G7 contractors. The survey shows that the acceptance, adoption, and deployment of IBS in the Malaysian construction industry are still low and do not address the persisting problems, such as productivity, dependency on foreign workers and high level of construction wastage.
IBS Diet

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... the most common questions IBS patients have is what food to avoid. This can drive a person to ... Global Treatments IBS Diet What to Do and What to Avoid Foods That Cause Cramping and Diarrhea Foods that Cause ...

Saddle-fin cell transistors with oxide etch rate control by using tilted ion implantation (TIS-fin) for sub-50-nm DRAMs

International Nuclear Information System (INIS)

Yoo, Min Soo; Choi, Kang Sik; Sun, Woo Kyung

2010-01-01

As DRAM cell pitch size decreases, the need for a high performance transistor is increasing. Though saddle-fin (S-fin) transistors have superior characteristics, S-fin transistors are well known to be more sensitive to process variation. To make uniform S-fin transistors, for the first time, we developed a new fin formation method using tilted ion implantation along the wordline direction after a recess gate etch. Due to the increased etch rate of the oxide film by ion implantation damage, fins are made at the bottom channel of the recess gate after wet etching. The resulting tilt implanted saddle-fin (TIS-fin) transistor has remarkably improved characteristics, such as ∼8% subthreshold swing (SS) and a 40% drain induced barrier lowering (DIBL) decrease. Especially, the TIS-fin with a neutral dopant has a reduced threshold voltage (Vth) variation within a wafer (<100 mV), which is comparable with that of a mass-produced sphere-shaped recessed channel array transistor (SRCAT).
Dose-response and failure pattern for bulky or barrel-shaped stage IB cervical cancer treated by combined photon irradiation and extrafascial hysterectomy

International Nuclear Information System (INIS)

Maruyama, Y.; van Nagell, J.R.; Yoneda, J.; Donaldson, E.; Gallion, H.H.; Higgins, R.; Powell, D.; Kryscio, R.; Berner, B.

1989-01-01

From 1975 to 1987, 80 patients with bulky or barrel-shaped Stage IB cervical cancer were treated with preoperative irradiation and Cs-137 intracavitary implant therapy, before a planned extrafascial abdominal hysterectomy, using a consistent treatment policy. Of the hysterectomy specimens obtained, 37% were positive histologically at 89 +/- 2.3 days after the start of radiotherapy and at 4 to 6 weeks after the completion of radiation therapy. Sixty-three percent were negative after a total external and internal cervix irradiation dose of 9642 cGy at point T. The average point A dose contributed by intracavitary therapy was 2104 cGy. The survival rate at 5 years was 84%: At 10 years the survival rate was 78%. The failure pattern was analyzed for patients who had positive and negative specimens. The patients with positive specimens failed pelvically or pelvically and distantly. Patients with negative specimens failed in extrapelvic or distant metastatic sites. Preoperative radiotherapy led to excellent local and pelvic control of tumor, and the failures became predominantly distant metastases. The combined radiosurgical therapy was tolerated well and allowed surgical staging of disease. This permitted earlier and selective consideration of adjunctive therapy (i.e., paraaortic irradiation, chemotherapy, or chemoradiotherapy). The dose-response data give insight into the effects of photon radiotherapy on bulky or barrel Stage IB cervical cancers and correlate histologic status with failure pattern, outcome, and long-term survival
Treatment of bulky stage IB and IIB cervical cancers with outpatient neutron brachytherapy, external pelvic radiation and extrafascial hysterectomy

International Nuclear Information System (INIS)

Van Nagell, J.R.; Maruyama, Y.; Yoneda, J.; Donaldson, E.S.; Hanson, M.B.; Gallion, H.H.; Powell, D.E.; Kryscio, R.J.

1986-01-01

From January, 1977, to December, 1982, twenty-nine patients with bulky (>4 cms diameter) Stage IB or IIB cervical cancer were treated at the University of Kentucky Medical Center by a combination of out-patient neutron brachytherapy (Cf-252) and external pelvic radiation followed by extrafascial hysterectomy. Residual tumor was present in the hysterectomy specimens of 25 per cent. Complications during and following radiation therapy and surgery were minimal and included vaginal stenosis, proctitis, and hemorrhagic cystitis. The mean duration of hospitalization for surgery in these patients was 6.6 days (range 5-15 days) and postoperative morbidity was low. No patient required blood transfusion. Four patients developed urinary tract infections and two had superficial wound separations. Following treatment, patients were seen at monthly intervals for one year, every three months for two years, and every six months thereafter. No patient has been lost to follow-up. Two patients (7 per cent) developed tumor recurrence and have died of disease (1 of distant metastases; 1 local). The remaining 27 patients (93 per cent) are alive and well with no evidence of disease 24-89 months (mean 48 months) after therapy. No radiogenic fistulae or bowel obstruction were observed. These preliminary results suggest that the combination of outpatient neutron brachytherapy, external pelvic radiation, and extrafascial hysterectomy for patients with Stage IB and IIB cervical cancer is well tolerated. Complications associated with this treatment regimen have been minimal, and the recurrence rate is low. The duration of intracavitary neutron brachytherapy was short, and outpatient therapy was well received by patients
Estrabismo após toxina botulínica para fins estéticos

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Marta Halfeld Ferrari Alves Lacordia

2011-06-01

Full Text Available RESUMO Nas últimas décadas, a toxina botulínica tem sido aplicada para fins terapêuticos em inúmeras afecções. A toxina do tipo A foi aprovada primeiramente em 1989 para o uso em estrabismo, blefaroespasmo e espasmo hemifacial de pacientes maiores que 12 anos de idade. A observação de que pacientes tratados de blefaroespasmo com toxina botulínica apresentavam um efeito adicional de diminuição das rugas de expressão inspirou estudos sobre a aplicação cosmética da toxina. Recentemente, a toxina botulínica do tipo A foi aprovada para fins estéticos. Este trabalho relata um caso de ocorrência de estrabismo após aplicação de toxina botulínica na face para fins estéticos.
Medications (for IBS)

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Jinetes en Grecia y sus ecos en la cultura ibérica

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Domínguez Monedero, Adolfo J.

2005-12-01

Full Text Available The uses of the horse in Greece are reviewed from the Mycenaean until Late Classical times in order to trace its development as a military weapon. Besides, the social projection of the use of the horse in Greece is also addressed, as well as the development of equestrian contests which served also as a means of stressing the social status of the leading groups within the Greek poleis. In a final chapter the possible reflections of the uses of the horse in Greece in the Iberian world are also considered, although the possible relationships are confined mainly to iconographical loans from Greek prototypes to some Iberian artistic manifestations.

Se pasa revista a los usos del caballo en Grecia desde época micénica hasta el final del Clasicismo a fin de observar su desarrollo como arma militar. Además, se estudia también la proyección social del uso del caballo en Grecia así como el desarrollo de competiciones ecuestres que sirvieron también como medio de exhibir el estatus social de los grupos dirigentes de las poleis griegas. En el capítulo final se consideran también los posibles ecos de los usos del caballo en Grecia en el mundo ibérico, aunque estas posibles relaciones se limitan sobre todo a préstamos iconográficos de modelos griegos a algunas manifestaciones artísticas ibéricas.
Medications (for IBS)

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The Species and Origin of Shark Fins in Taiwan’s Fishing Ports, Markets, and Customs Detention: A DNA Barcoding Analysis

Science.gov (United States)

Chuang, Po-Shun; Hung, Tzu-Chiao; Chang, Hung-An; Huang, Chien-Kang; Shiao, Jen-Chieh

2016-01-01

The increasing consumption of shark products, along with the shark’s fishing vulnerabilities, has led to the decrease in certain shark populations. In this study we used a DNA barcoding method to identify the species of shark landings at fishing ports, shark fin products in retail stores, and shark fins detained by Taiwan customs. In total we identified 23, 24, and 14 species from 231 fishing landings, 316 fin products, and 113 detained shark fins, respectively. All the three sample sources were dominated by Prionace glauca, which accounted for more than 30% of the collected samples. Over 60% of the species identified in the fin products also appeared in the port landings, suggesting the domestic-dominance of shark fin products in Taiwan. However, international trade also contributes a certain proportion of the fin product markets, as four species identified from the shark fin products are not found in Taiwan’s waters, and some domestic-available species were also found in the customs-detained sample. In addition to the species identification, we also found geographical differentiation in the cox1 gene of the common thresher sharks (Alopias vulpinus), the pelagic thresher shark (A. pelagicus), the smooth hammerhead shark (Sphyrna zygaena), and the scalloped hammerhead shark (S. lewini). This result might allow fishing authorities to more effectively trace the origins as well as enforce the management and conservation of these sharks. PMID:26799827
Motivational Factors on Adopting Modular Coordination Concept in Industrialized Building System (IBS

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Yunus Riduan

2016-01-01

Full Text Available Modular coordination (MC is recognized as a tool towards rationalization and industrialization. The implementation of MC concept in the design stage may improve the constructability and construction time. However, the implementation of MC in Industrialized Building System (IBS implementation is still low compare to other developed countries such as the United Kingdom, Sweden and Japan. This paper examined the interrelationship between motivational factors of stakeholders in adopting MC concept using Interpretative Structural Modeling (ISM. Questionnaire survey was engaged in this study to identify significant motivational factors. Then, semi-structure interviews were used to collect qualitative data. ISM was adopted to build relationship between factors and develop an initial model to promote the adoption of MC in IBS construction. Seven (7 significant motivational factors were identified in this research namely 1 ‘stakeholder’s commitment’, 2 ‘reduce site disruption’, 3 ‘increase productivity’, 4 ‘high skilled workers’, 5 ‘site sustainability (environment, economy and social benefits’ 6 ‘standardization’ and 7 ‘enabling ‘open building’ concept’. The result using Matrice d’Impacts Croises Multiplication Applique an Clasment (MICMAC shows that there are three factors can be categorized as Independent / Driving Factors namely ‘stakeholder’s commitment’, ‘standardization’ and ‘enabling “open building” concept’. These factors should be explored in details to enhance the adoption of IBS in Malaysia. The findings provide a very good platform for a further research in formulating an efficient solution to promote MC concept adoption among the stakeholders. This scenario will improve the deliverables of IBS construction and eliminate negative perception in its implementation.
Resistance to sulfur poisoning of Ni-based alloy with coinage (IB) metals

International Nuclear Information System (INIS)

Xu, Xiaopei; Zhang, Yanxing; Yang, Zongxian

2015-01-01

Highlights: • The effects of IB metal dopants on the S poisoning features of Ni are analyzed. • IB metal dopants can modify the surface electronic structure of Ni. • IB metal dopants can increase the S tolerance of Ni at an optimized concentration. • Au is a preferred dopant to increase the resistance to sulfur poisoning of Ni. - Abstract: The poisoning effects of S atom on the (1 0 0), (1 1 0) and (1 1 1) metal surfaces of pure Ni and Ni-based alloy with IB (coinage) metals (Cu, Ag, Au) are systematically studied. The effects of IB metal dopants on the S poisoning features are analyzed combining the density functional theory (DFT) results with thermodynamics data using the ab initio atomistic thermodynamic method. It is found that introducing IB doping metals into Ni surface can shift the d-band center downward from the Fermi level and weaken the adsorption of S on the (1 0 0) and (1 1 0) surfaces, and the S tolerance ability increases in the order of Ni, Cu/Ni, Ag/Ni and Au/Ni. Nevertheless, on the (1 1 1) surface, the S tolerance ability increases in the order of Ag/Ni (or Cu/Ni), Ni, and Au/Ni. When we increase the coverage of the IB metal dopants, we found that not only Au, but Cu and Ag can increase its S tolerance. We therefore propose that alloying can increase its S tolerance and alloying with Au would be a better way to increase the resistance to sulfur poisoning of the Ni anode as compared with the pure Ni and the Ag- or, Cu-doped Ni materials.
Al-Shāṭibīs sufismekritik:

DEFF Research Database (Denmark)

Riexinger, Martin Thomas

2016-01-01

The faqīh (Islamic legal scholar) al-Shāṭibī (d. 1388) from Granada is primarily known for his innovative approach within the field of legal theory (uṣūl al-fiqh). However, he dedicated much attention to the criticism of sufism. But like other Islamic scholars who opposed Sufism he did...
[Validation of the IBS-SSS].

Science.gov (United States)

Betz, C; Mannsdörfer, K; Bischoff, S C

2013-10-01

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterised by abdominal pain, associated with stool abnormalities and changes in stool consistency. Diagnosis of IBS is based on characteristic symptoms and exclusion of other gastrointestinal diseases. A number of questionnaires exist to assist diagnosis and assessment of severity of the disease. One of these is the irritable bowel syndrome - severity scoring system (IBS-SSS). The IBS-SSS was validated 1997 in its English version. In the present study, the IBS-SSS has been validated in German language. To do this, a cohort of 60 patients with IBS according to the Rome III criteria, was compared with a control group of healthy individuals (n = 38). We studied sensitivity and reproducibility of the score, as well as the sensitivity to detect changes of symptom severity. The results of the German validation largely reflect the results of the English validation. The German version of the IBS-SSS is also a valid, meaningful and reproducible questionnaire with a high sensitivity to assess changes in symptom severity, especially in IBS patients with moderate symptoms. It is unclear if the IBS-SSS is also a valid questionnaire in IBS patients with severe symptoms because this group of patients was not studied. © Georg Thieme Verlag KG Stuttgart · New York.
Stadium IB - IIA cervical cancer patient’s survival rate after receiving definitive radiation and radical operation therapy followed by adjuvant radiation therapy along with analysis of factors affecting the patient’s survival rate

Science.gov (United States)

Ruslim, S. K.; Purwoto, G.; Widyahening, I. S.; Ramli, I.

2017-08-01

To evaluate the characteristics and overall survival rates of early stage cervical cancer (FIGO IB-IIA) patients who receive definitive radiation therapy and those who are prescribed adjuvant postoperative radiation and to conduct a factors analysis of the variables that affect the overall survival rates in both groups of therapy. The medical records of 85 patients with cervical cancer FIGO stages IB-IIA who were treated at the Department of Radiotherapy of Cipto Mangunkusumo Hospital were reviewed and analyzed to determine their overall survival and the factors that affected it between a definitive radiation group and an adjuvant postoperative radiation group. There were 25 patients in the definitive radiation and 60 patients in the adjuvant radiation group. The overall survival rates in the adjuvant radiation group at years one, two, and three were 96.7%, 95%, and 93.3%, respectively. Negative lymph node metastasis had an average association with overall survival (p 12 g/dl was a factor with an average association with the overall survival (p cervical cancer FIGO stage IB-IIA patients who received definitive radiation or adjuvant postoperative radiation. Negative lymph node metastasis had an effect on the overall survival rate in the adjuvant postoperative radiation group, while a preradiation Hb level >12 g/dl tended to affect the overall survival in the definitive radiation group patients.
Medications (for IBS)

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Medications (for IBS)

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Medications (for IBS)

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Medications (for IBS)

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Full Text Available ... the lack of effective treatment for the overall improvement of multiple symptoms in IBS patients. However, new ... IFFGD Our Mission Awareness Activities Advocacy Activities Research Leadership Industry Council Contact us IBS Treatment Working With ...
Medications (for IBS)

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Full Text Available ... by a physician who specializes in motility or stress-related gastrointestinal disorders. More complex medication regimens, and ... IBS Medications Probiotics and Antibiotics Psychological Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation Techniques for IBS Take ...
Medications (for IBS)

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Medications (for IBS)

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Full Text Available ... Diet Complementary or Alternative Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS ... Diet Complementary or Alternative Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS ...
Medications (for IBS)

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Full Text Available ... Agents Antidepressant Medications Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in ... Agents Antidepressant Medications Newer IBS Medications Probiotics and Antibiotics Psychological Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation ...
Control characteristics for wrap-around fins on cruise missiles configurations

Science.gov (United States)

Sawyer, W. C.; Monta, W. J.; Carter, W. V.; Alexander, W. K.

1981-01-01

This paper presents selected results of a panel loads study conducted as part of the final phase of an extensive investigation of an air-breathing missile concept employing wrap-around aerodynamic surfaces. Typical results for M = 2.36 are presented for the fin load results, plus a brief review of basic results of the previously reported tests. Vapor screen results are also discussed. The present results indicate that the fin load characteristics are nearly identical for planar and curved fins having the same projected planform and would permit the use of planar-surface predictions for supersonic speeds in the preliminary design stages of missiles employing wrap-around curved fins.
Medications (for IBS)

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Medications (for IBS)

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Full Text Available ... have limited benefit for treating IBS. In some persons they relieve abdominal pain or discomfort, usually if ... Anti-anxiety medications – can be helpful for some people with IBS, mainly those with emotional distress. There ...
Medications (for IBS)

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IBS Treatment Options

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... 01 July 2017 Print A short bout of abdominal pain and diarrhea or constipation now and then is not unusual. But long-term or recurring symptoms are not normal. They may signal irritable bowel syndrome (IBS) – and are generally treatable. IBS Treatments Depend ...
iB1350 no.3. Passive double confinement and SA population dose evaluation for the iB1350

International Nuclear Information System (INIS)

Sato, Takashi; Matsumoto, Keiji; Hosomi, Kenji; Iwasaki, Ryuji

2017-01-01

iB1350 stands for an innovative, intelligent and inexpensive BWR 1350. It is the first Generation III.7 reactor after the Fukushima Daiichi accident. The iB1350 uses the Mark W containment and the in-containment filtered venting system (IFVS). The Mark W containment is made of reinforced concrete and has double cylinder FP barriers. There are also IC/iPCCS pools, a fuel pool and a dryer separator (DS) pool on the top slab of the containment. These pools work as water seal for FP leakage through the top slab. Most FP such as CsI are scrubbed in the pools. The containment head is also submerged in the reactor well pool. The pool water works as shielding for radiation from the reactor core during normal operation and water seal for FP scrubbing during a severe accident. The base mat concrete is covered with the S/P and the core catcher that is also submerged with corium flooding water during an accident. Therefore, the Mark W containment has passive double confinement barriers for FP. Moreover, the IFVS works as in-containment filtered venting system that scrubs FP from the wet well (WW) and the dry well (DW). The filtered venting tank is arranged in the outer well (OW) of the Mark W containment. Even noble gases and organic iodine going through the filtered venting system are still confined inside the containment and never released directly to the environment. The IFVS uses the innovative passive containment cooling system (iPCCS) as the pre-stage heat removal system. The iPCCS has a normal open suction line from the WW. Therefore, FP are scrubbed in the S/P at first and then vented into the filtered venting tank. After the DW suction line of the iPCCS is opened all the steam is cooled and condensed in the heat exchanger. Most FP are trapped in the condensate and returned into the WW through the condensate return line of the iPCCS. Therefore, the Mark W containment has excellent FP double confinement barriers and the in-containment filtered venting system that enable
El estudio de la Fauna Ibérica

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Ramos Sánchez, María Ángeles

2007-10-01

Full Text Available Since the beginning in 1989, Fauna Ibérica has promoted coordinated research in Taxonomy bringing together more than 100 Spanish and non-Spanish experts. The programme supported by CSIC Presidency is lead by Museo Nacional de Ciencias Naturales. As a result, 30 Fauna Ibérica monographs has been published in addition to a year average of 50-60 scientific papers describing more than 50 new species per year. IBERFAUNA, the Data Bank of the Spanish Fauna, has been created including 38.000 out of the 61.000 species estimated to live in the Iberian Peninsula and Balearic Islands. This area is confirmed as one of the most biodiverse of the European Union with more than 50 % of the European species and more than 50 % of its endemics. Among future plans, a more stable organization is proposed in order to: maintaining dichotomy paper/digital publications, increasing interactivity among taxonomists and training, developing cyber-tools to facilitate public access to the information and increasing the strength of Fauna Ibérica through collaboration with other international initiatives and other areas of knowledge.Desde su inicio en 1989, Fauna Ibérica ha impulsado la investigación coordinada de más de 100 taxónomos españoles y extranjeros. El programa, apoyado por la Presidencia del CSIC, está dirigido por el Museo Nacional de Ciencias Naturales. Como resultado, se han publicado 30 monografías de la serie Fauna Ibérica, y un promedio anual de 50-60 artículos científicos que describen más de 50 nuevas especies por año. Se ha creado el Banco de Datos, IBERFAUNA, que cuenta ya con 38.000 de las aproximadamente 61.000 especies que habitan en la Península Ibérica y Baleares. Se confirma como una de las regiones más ricas en biodiversidad de la Unión Europea, con más del 50 % de las especies y más de un 50 % de sus endemismos. Entre los planes de futuro, se propone una estructura estable para Fauna Ibérica, que mantenga la dicotomía soporte
Carlos Hugo Molina Saucedo. Andrés Ibáñez, un caudillo para el siglo XXI. La Comuna de Santa Cruz de la Sierra de 1876; Andrey Schelchkov. Andrés Ibáñez y la Revolución de la Igualdad en Santa Cruz: primer ensayo de federalismo en Bolivia, 1876-1877

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Clayton Mendonça Cunha Filho

2014-11-01

Full Text Available Carlos Hugo Molina Saucedo. Andrés Ibáñez, un caudillo para el siglo XXI. La Comuna de Santa Cruz de la Sierra de 1876Andrey Schelchkov. Andrés Ibáñez y la Revolución de la Igualdad en Santa Cruz: primer ensayo de federalismo en Bolivia, 1876-1877
Medications (for IBS)

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FinTech in Denmark

OpenAIRE

Hategan, Ramona Anamaria; Mockus, Gytis; Trinkunaite, Sarune

2017-01-01

ABSTRACTThe purpose of this paper has been to seek understanding and knowledge of FinTech phenomenon, with a particular focus on the effect of its emergence on the Danish financial sector. We have attempted to answer our initial research question with the help of a theoretical and methodological framework conceived of concepts belonging to Actor-Network Theory, Diffusion of Innovation Theory and alluding to Foucault’s concepts of power, knowledge and discourses. We have followed FinTech as an...
The Insight of Industrialised Building System (IBS By Bumiputera Construction Players

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Muhammad W. M. N. W.

2016-01-01

Full Text Available The term Industrialised Building System (IBS is widely recognised by construction players in Malaysia since its first implementation since 1960s for IBS pilot projects of Pekeliling Flats and Rifle Range Flats. The aim for the implementation is to promote better system in delivering construction end-products which offers efficiency and effectiveness. At the same time, Bumiputera construction players are the majority of parties in construction industry especially in Small and Medium Enterprises (SMEs. Therefore, the purpose of this paper is to identify the perception and awareness of IBS implementation among Bumiputera players. It is found that, Bumiputera construction players have sound knowledge on the IBS and optimistic towards further implementation for future projects. Nonetheless, issues on payment methods and coordination of IBS project delivery are found to be the negative perceptions which are considered as hindrance for Bumiputera construction players’ involvement in IBS project.
Exclusion of the GNAS locus in PHP-Ib patients with broad GNAS methylation changes: evidence for an autosomal recessive form of PHP-Ib?

Science.gov (United States)

Fernández-Rebollo, Eduardo; Pérez de Nanclares, Guiomar; Lecumberri, Beatriz; Turan, Serap; Anda, Emma; Pérez-Nanclares, Gustavo; Feig, Denice; Nik-Zainal, Serena; Bastepe, Murat; Jüppner, Harald

2011-08-01

Most patients with autosomal dominant pseudohypoparathyroidism type Ib (AD-PHP-Ib) carry maternally inherited microdeletions upstream of GNAS that are associated with loss of methylation restricted to GNAS exon A/B. Only few AD-PHP-Ib patients carry microdeletions within GNAS that are associated with loss of all maternal methylation imprints. These epigenetic changes are often indistinguishable from those observed in patients affected by an apparently sporadic PHP-Ib form that has not yet been defined genetically. We have now investigated six female patients affected by PHP-Ib (four unrelated and two sisters) with complete or almost complete loss of GNAS methylation, whose healthy children (11 in total) showed no epigenetic changes at this locus. Analysis of several microsatellite markers throughout the 20q13 region made it unlikely that PHP-Ib is caused in these patients by large deletions involving GNAS or by paternal uniparental isodisomy or heterodisomy of chromosome 20 (patUPD20). Microsatellite and single-nucleotide variation (SNV) data revealed that the two affected sisters share their maternally inherited GNAS alleles with unaffected relatives that lack evidence for abnormal GNAS methylation, thus excluding linkage to this locus. Consistent with these findings, healthy children of two unrelated sporadic PHP-Ib patients had inherited different maternal GNAS alleles, also arguing against linkage to this locus. Based on our data, it appears plausible that some forms of PHP-Ib are caused by homozygous or compound heterozygous mutation(s) in an unknown gene involved in establishing or maintaining GNAS methylation. Copyright © 2011 American Society for Bone and Mineral Research.
La gestión social del sílex melado durante el Neolítico medio en el nordeste de la Península Ibérica

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Terradas, Xavier

2002-06-01

Full Text Available Not Available.

[es] En este artículo presentamos la reconstrucción de las estrategias desarrolladas en la gestión de un recurso mineral concreto, el sílex melado presumiblemente procedente del valle del Ródano, por los grupos humanos que durante el Neolítico medio habitaron el nordeste peninsular. A partir de los restos líticos recuperados en varios yacimientos catalanes constatamos una fragmentación en el tiempo y el espacio de los procedimientos técnicos aplicados en la explotación de esta materia prima de origen lejano, orientada hacia la generación de una mayor rentabilidad de las actividades económicas desarrolladas. Sin embargo, esta rentabilidad entra en contradicción con el fin al que fueron destinados una gran parte de los productos obtenidos, como elementos de ajuaren inhumaciones individuales conocidas como sepulcros de fosa, al tratarse de productos no utilizados o todavía operativos desde un punto de vista funcional. [fr] La gestion sociale du silex blond durant le Néolithique Moyen au Nord-Est de la Péninsule Ibérique. Nous présentons ici la reconstruction des stratégies mises en œuvre dans la gestion d'un ressource minéral concret, le silex blond présumablement procédant de la vallée du Rhône, par les groupes humaines que pendant le Néolithique moyen habitèrent le nord-est de la Péninsule ibérique. A partir des vestiges lithiques récupérés dans plusieurs sites catalanes on constate une fragmentation dans le temps et l'espace des procédés techniques mises en œuvre par l'exploitation de cette matière première d'origine lointaine, dirigée vers l'obtention d'une plus grande rentabilité des activités économiques. Néanmoins, cette rentabilité est en contradiction avec la destination d'une grande partie des produits obtenus, encore opératifs du point de vue fonctionnel ou pas utilisés, vers des inhumations individuelles connues comme sépulcres de fosse.
IBS for non-gaussian distributions

International Nuclear Information System (INIS)

Fedotov, A.; Sidorin, A.O.; Smirnov, A.V.

2010-01-01

In many situations distribution can significantly deviate from Gaussian which requires accurate treatment of IBS. Our original interest in this problem was motivated by the need to have an accurate description of beam evolution due to IBS while distribution is strongly affected by the external electron cooling force. A variety of models with various degrees of approximation were developed and implemented in BETACOOL in the past to address this topic. A more complete treatment based on the friction coefficient and full 3-D diffusion tensor was introduced in BETACOOL at the end of 2007 under the name 'local IBS model'. Such a model allowed us calculation of IBS for an arbitrary beam distribution. The numerical benchmarking of this local IBS algorithm and its comparison with other models was reported before. In this paper, after briefly describing the model and its limitations, they present its comparison with available experimental data.
Disparities in Adherence to National Comprehensive Cancer Network Treatment Guidelines and Survival for Stage IB-IIA Cervical Cancer in California.

Science.gov (United States)

Pfaendler, Krista S; Chang, Jenny; Ziogas, Argyrios; Bristow, Robert E; Penner, Kristine R

2018-05-01

To evaluate the association of sociodemographic and hospital characteristics with adherence to National Comprehensive Cancer Network treatment guidelines for stage IB-IIA cervical cancer and to analyze the relationship between adherent care and survival. This is a retrospective population-based cohort study of patients with stage IB-IIA invasive cervical cancer reported to the California Cancer Registry from January 1, 1995, through December 31, 2009. Adherence to National Comprehensive Cancer Network guideline care was defined by year- and stage-appropriate surgical procedures, radiation, and chemotherapy. Multivariate logistic regression, Kaplan-Meier estimate, and Cox proportional hazard models were used to examine associations between patient, tumor, and treatment characteristics and National Comprehensive Cancer Network guideline adherence and cervical cancer-specific 5-year survival. A total of 6,063 patients were identified. Forty-seven percent received National Comprehensive Cancer Network guideline-adherent care, and 18.8% were treated in high-volume centers (20 or more patients/year). On multivariate analysis, lowest socioeconomic status (adjusted odds ratio [OR] 0.69, 95% CI 0.57-0.84), low-middle socioeconomic status (adjusted OR 0.76, 95% CI 0.64-0.92), and Charlson-Deyo comorbidity score 1 or higher (adjusted OR 0.78, 95% CI 0.69-0.89) were patient characteristics associated with receipt of nonguideline care. Receiving adherent care was less common in low-volume centers (45.9%) than in high-volume centers (50.9%) (effect size 0.90, 95% CI 0.84-0.96). Death from cervical cancer was more common in the nonadherent group (13.3%) than in the adherent group (8.6%) (effect size 1.55, 95% CI 1.34-1.80). Black race (adjusted hazard ratio 1.56, 95% CI 1.08-2.27), Medicaid payer status (adjusted hazard ratio 1.47, 95% CI 1.15-1.87), and Charlson-Deyo comorbidity score 1 or higher (adjusted hazard ratio 2.07, 95% CI 1.68-2.56) were all associated with increased
Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer

Science.gov (United States)

2017-05-03

Stage I Ovarian Cancer; Stage IA Fallopian Tube Cancer; Stage IB Fallopian Tube Cancer; Stage IC Fallopian Tube Cancer; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIB Fallopian Tube Cancer; Stage IIC Fallopian Tube Cancer; Stage III Ovarian Cancer; Stage III Primary Peritoneal Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIC Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer
A Preliminary Review on Economies of Scale (EOS Towards Industrialized Building System (IBS Manufacturer

Directory of Open Access Journals (Sweden)

Tajul Ariffin Syazwana

2017-01-01

Full Text Available Industrialized Building System (IBS is a potential technology to improve productivity of construction industry. Controlled production and minimum generation of construction waste are some of the benefits that can be achieved by replacing conventional construction with IBS. In business, IBS is giving a huge opportunity for manufacturer and supplier to expand their business while contributing to construction development. However, bad strategies will put the company in high risk due to higher initial capital for machines and equipment. Therefore, strategic planning for company’s growth, profit maximization, and enhancement of productivity is undeniable to ensure the success of business in construction industry. This preliminary paper is exploring associated factors that affect Economy of Scale (EOS and their relationships in catalyzing the IBS manufacturer especially precast concrete as the scope of study to continue their business in the construction industry. Thus, a framework of EOS is proposed to assist IBS manufacturers to ensure their company’s growth and stability, competitiveness in term of monopoly or an oligopoly, increasing productivity, leading constant returns to scale, and finally increasing the firm’s efficiency. The refined EOS’s conceptual framework is an important turning point to support the development of decision making tools for IBS manufacturer towards their stability and survival in this highly competitive industry.

Effect of the Curved Fin Top Edge on the Electrical Characteristics of FinFETs.

Science.gov (United States)

Ahn, Joonsung; Kim, Tae Whan

2018-03-01

The effect of the curved fin top edge on the electrical characteristics of FinFETs was investigated. The curvature radius of the fin top edge for the FinFETs was changed from 0 to 5 nm in order to determine the optimum condition of the electrical characteristics for the devices. The on-current level of the FinFETs with a curvature radius of 5 nm of fin top edge was 24.45% larger than that of the FinFETs with a cuboid fin. The electron current density and the electron mobility of the fin top edge for the FinFETs were larger than those for the FinFETs with a cuboid fin. The electrical characteristics of the FinFETs with a curvature radius of 5 nm for the fin top edge showed the best performance due to the largest expansion of the effective channel region.
Preoperative radium therapy and radical hysterectomy in the treatment of cervical cancer stage IB, IIA, and initial IIB.; Radiumterapia pre-operatoria e histerectomia radical no tratamento do cancer do colo uterino IB, IIA e IIB inicial

Energy Technology Data Exchange (ETDEWEB)

Salum, Resalla; Lopes, Edison R.; Souza, Maria A.H. de [Faculdade de Medicina do Triangulo Mineiro, Uberaba, MG (Brazil). Hospital Escola

1995-07-01

Patients with IB, IIa and in initial IIb cervical cancer were randomized for combined therapy, consisting of one or two radium insertion followed by Wertheim Meigs operation performed 40 days later. We look for the early and late complications of the treatment, residual cancer after radiotherapy and survival without recurrence. The project begin in 1965 and ended in 1986. All the operations were done by one of the investigators and 116 patients were analysed. The age ranged from 21 to 75 years with an average of 4.18 years. During the operations 31 (26.72%) patients needed 1.500 cc or greater amount of blood transfusion and we have 3 iliac veins lesions. Managing the ureters, we do our best to leave the posterior fascia as intact as possible. Post operative complications ranged from minor (fever, localised pelvic infections, temporary popliteal nerve paralysis) to evisceration (3 patients) deep venous thrombosis (3 patients) and two early urinary fistulas. Late complications were seen in patients submitted to sequential teletherapy irradiation. One uretrovaginal fistula occurred 10 month after treatment, another one, 7 years later and the third one 24 years later. One patient develop hydronefrosis and enterocolite after 7.000 rads of teletherapy and another one rectovaginal fistula 13 years after initial therapy. The shortening of the vagina making impossible the intercourse was seen in 7 patients. By the histological examination, the cervix was sterilized in 73.3 % of the patients. Residual cancer was found according the original size of the tumour and the stage of the disease. Studying different combinations between the existence of residual cervical cancer with positive or negative limphnodes and making a correlation with survival, we found the critical points is to have positive cervix and positive lymphonodes. The five years survival (life table methodology) for stage 1 lesion was 96%; stage II, 67%. At ten years survival was slighted different. With positive
The Interstitial Status of Irish Gayness in Colm Tóibín’s The Blackwater Lightship and The Master

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José M. Yebra

2014-03-01

Full Text Available This paper explores the liminal status of Irish gayness in the aftermath of its decriminalization in 1993. Colm Tóibín’s The Blackwater Lightship (1999 tries to reconcile Irish Catholicism and traditional family with new models of Irishness. Declan, the protagonist of the novel, goes back home when he is about to die of AIDS. His return reveals a dysfunctional family which only his disease brings together. His grandmother, mother and sister mourn Declan’s corpse-like body. Making reference to Julia Kristeva’s concepts of “abjection” and “the chora” (1982, 1984, I contend that the hero’s disease is a necessary sacrifice for the family and Ireland as a whole to resurface. The second part of the paper addresses Tóibín’s The Master (2004, whose fictional Henry James counterbalances Declan’s overt homosexuality and AIDS-related death. The Master delves into James’s hybridity as a closeted American of Irish descent opposed to Oscar Wilde’s flamboyant gay Irishness. The restraint of the former and the traumatic downfall of the latter make up the late-Victorian framework through which Declan’s late-twentieth-century sacrifice becomes meaningful.
Optimal design of the first stage of the plate-fin heat exchanger for the EAST cryogenic system

Science.gov (United States)

Qingfeng, JIANG; Zhigang, ZHU; Qiyong, ZHANG; Ming, ZHUANG; Xiaofei, LU

2018-03-01

The size of the heat exchanger is an important factor determining the dimensions of the cold box in helium cryogenic systems. In this paper, a counter-flow multi-stream plate-fin heat exchanger is optimized by means of a spatial interpolation method coupled with a hybrid genetic algorithm. Compared with empirical correlations, this spatial interpolation algorithm based on a kriging model can be adopted to more precisely predict the Colburn heat transfer factors and Fanning friction factors of offset-strip fins. Moreover, strict computational fluid dynamics simulations can be carried out to predict the heat transfer and friction performance in the absence of reliable experimental data. Within the constraints of heat exchange requirements, maximum allowable pressure drop, existing manufacturing techniques and structural strength, a mathematical model of an optimized design with discrete and continuous variables based on a hybrid genetic algorithm is established in order to minimize the volume. The results show that for the first-stage heat exchanger in the EAST refrigerator, the structural size could be decreased from the original 2.200 × 0.600 × 0.627 (m3) to the optimized 1.854 × 0.420 × 0.340 (m3), with a large reduction in volume. The current work demonstrates that the proposed method could be a useful tool to achieve optimization in an actual engineering project during the practical design process.
Radical surgery compared with intracavitary cesium followed by radical surgery in cervical carcinoma stage IB

Energy Technology Data Exchange (ETDEWEB)

Tinga, D.J.; Bouma, J.; Aalders, J.G. (Dept. of Obstetrics and Gynaecology, State Univ. Hospital, Groningen (Netherlands)); Hollema, H. (Dept. of Pathology, State Univ. Hospital, Groningen (Netherlands))

1990-01-01

Forty-nine patients aged {le} 45 years, with cervical carcinoma stage IB ({le} 3 cm) were treated with either primary radical surgery (n = 26), or intracavitary irradiation followed by radical surgery (n = 23). With primary surgery, ovarian function had been preserved in 15 of the 25 patients, who were alive and well. Seven of the primary surgery patients were irradiated postoperatively and 2 others with a central recurrence were cured by irradiation. One other patient, who was not irradiated postoperatively, had an intestinal metastasis and died of the disease. If any of the adverse prognostic factors (as reported in the literature) had been considered as an indication for postoperative irradiation, 17 patients instead of 7 would have been irradiated after primary radical surgery. In the comparable group of 23 patients treated by intracavitary irradiation and radical surgery (and in 4 cases postoperative irradiation as well) there was no recurrence. There was no significant statistical difference between the treatment results in the cesium + surgery group and those who underwent primary radical surgery. Young patients with early cervical carcinoma without prognostic indicators for postoperative irradiation can benefit from primary radical surgery, because their ovarian function can be preserved. (authors).
Radical surgery compared with intracavitary cesium followed by radical surgery in cervical carcinoma stage IB

International Nuclear Information System (INIS)

Tinga, D.J.; Bouma, J.; Aalders, J.G.; Hollema, H.

1990-01-01

Forty-nine patients aged ≤ 45 years, with cervical carcinoma stage IB (≤ 3 cm) were treated with either primary radical surgery (n = 26), or intracavitary irradiation followed by radical surgery (n = 23). With primary surgery, ovarian function had been preserved in 15 of the 25 patients, who were alive and well. Seven of the primary surgery patients were irradiated postoperatively and 2 others with a central recurrence were cured by irradiation. One other patient, who was not irradiated postoperatively, had an intestinal metastasis and died of the disease. If any of the adverse prognostic factors (as reported in the literature) had been considered as an indication for postoperative irradiation, 17 patients instead of 7 would have been irradiated after primary radical surgery. In the comparable group of 23 patients treated by intracavitary irradiation and radical surgery (and in 4 cases postoperative irradiation as well) there was no recurrence. There was no significant statistical difference between the treatment results in the cesium + surgery group and those who underwent primary radical surgery. Young patients with early cervical carcinoma without prognostic indicators for postoperative irradiation can benefit from primary radical surgery, because their ovarian function can be preserved. (authors)
Numerical Analysis of Aerodynamic Characteristics of the Finned Surfaces with Cross-inclined Fins

Directory of Open Access Journals (Sweden)

Lagutin A. E.

2016-12-01

Full Text Available This paper presents results of numerical research and analyses air-side hydraulic performance of tube bundles with cross inclined fins. The numerical simulation of the fin-tube heat exchanger was performed using the Comsol Femlab software. The results of modeling show the influence of fin inclination angle and tube pitch on hydraulic characteristics of finned surfaces. A series of numerical tests were carried out for tube bundles with different inclination angles (γ =900, 850, 650, 60, the fin pitch u=4 mm. The results indicate that tube bundles with cross inclined fins can significantly enhance the average integral value of the air flow rate in channel between fins in comparison with conventional straight fins. Aerodynamic processes on both sides of modificated channel between inclined fins were analyzed. The verification procedures for received results of numerical modeling with experimental data were performed.
Frost behavior of a fin surface with temperature variation along heat exchanger fins

International Nuclear Information System (INIS)

Kim, Jung Soo; Kim, Min Soo; Lee, Kwan Soo; Kim, Ook Joong

2007-01-01

This paper presents a mathematical model for predicting the frost behavior formed on heat exchanger fins, considering fin heat conduction under frosting condition. The model is composed of air-side, the frost layer, and fin region, and they are coupled to the frost layer. The frost behavior is more accurately predicted with fin heat conduction considered (Case A) than with a constant fin surface temperature assumed (Case B). The results indicate that the frost thickness and heat transfer rate for Case B are over-predicted in most regions of the fin, as compared to those for Case A. Also, for Case A, the maximum frost thickness varies little with the fin length variations, and the extension of the fin length over 30 mm contributes insignificantly to heat transfer
6 Tips: IBS and Complementary Health Practices

Science.gov (United States)

... health practice for IBS, here are 6 tips: Hypnotherapy (hypnosis). This practice involves the power of suggestion by ... IBS. According to reviews of the scientific literature, hypnotherapy may be a helpful treatment for managing IBS ...
A biorobotic model of the sunfish pectoral fin for investigations of fin sensorimotor control

International Nuclear Information System (INIS)

Phelan, Chris; Tangorra, James; Lauder, George; Hale, Melina

2010-01-01

A comprehensive understanding of the control of flexible fins is fundamental to engineering underwater vehicles that perform like fish, since it is the fins that produce forces which control the fish's motion. However, little is known about the fin's sensory system or about how fish use sensory information to modulate the fin and to control propulsive forces. As part of a research program that involves neuromechanical and behavioral studies of the sunfish pectoral fin, a biorobotic model of the pectoral fin and of the fin's sensorimotor system was developed and used to investigate relationships between sensory information, fin ray motions and propulsive forces. This robotic fin is able to generate the motions and forces of the biological fin during steady swimming and turn maneuvers, and is instrumented with a relatively small set of sensors that represent the biological lateral line and receptors hypothesized to exist intrinsic to the pectoral fin. Results support the idea that fin ray curvature, and the pressure in the flow along the wall that represents the fish body, capture time-varying characteristics of the magnitude and direction of the force created throughout a fin beat. However, none of the sensor modalities alone are sufficient to predict the propulsive force. Knowledge of the time-varying force vector with sufficient detail for the closed-loop control of fin ray motion will result from the integration of characteristics of many sensor modalities.
Embedded SMA wire actuated biomimetic fin: a module for biomimetic underwater propulsion

International Nuclear Information System (INIS)

Wang Zhenlong; Hang Guanrong; Wang Yangwei; Li Jian; Du Wei

2008-01-01

An embedded shape memory alloy (SMA) wire actuated biomimetic fin is presented, and based on this module for biomimetic underwater propulsion, a micro robot fish (146 mm in length, 30 g in weight) and a robot squid (242 mm in length, 360 g in weight) were developed. Fish swim by undulating their body and/or fins. Squid and cuttlefish can also swim by undulating their fins. To simplify engineering modeling, the undulating swimming movement is assumed to be the integration of the movements of many flexible bending segments connected in parallel or in series. According to this idea, a biomimetic fin which can bend flexibly was developed. The musculature of a cuttlefish fin was investigated to aid the design of the biomimetic fin. SMA wires act as 'muscle fibers' to drive the biomimetic fin just like the transverse muscles of the cuttlefish fin. During the bending phase, elastic energy is stored in the elastic substrate and skin, and during the return phase, elastic energy is released to power the return movement. Theorem analysis of the bending angle was performed to estimate the bending performance of the biomimetic fin. Experiments were carried out on single-face fins with latex rubber skin and silicone skin (SF-L and SF-S) to compare the bending angle, return time, elastic energy storage and reliability. Silicone was found to be the better skin. A dual-face fin with silicone skin (DF-S) was tested in water to evaluate the actuating performance and to validate the reliability. Thermal analysis of the SMA temperature was performed to aid the control strategy. The micro robot fish and robot squid employ one and ten DF-S, respectively. Swimming experiments with different actuation frequencies were carried out. The speed and steering radius of the micro robot fish reached 112 mm s −1 and 136 mm, respectively, and the speed and rotary speed of the robot squid reached 40 mm s −1 and 22° s −1 , respectively
50 CFR 600.1204 - Shark finning; possession at sea and landing of shark fins.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Shark finning; possession at sea and landing of shark fins. 600.1204 Section 600.1204 Wildlife and Fisheries FISHERY CONSERVATION AND... PROVISIONS Shark Finning § 600.1204 Shark finning; possession at sea and landing of shark fins. (a)(1) No...
Seventh edition (2010) of the AJCC/UICC staging system for gastric adenocarcinoma: is there room for improvement?

Science.gov (United States)

Patel, Manali I; Rhoads, Kim F; Ma, Yifei; Ford, James M; Visser, Brendan C; Kunz, Pamela L; Fisher, George A; Chang, Daniel T; Koong, Albert; Norton, Jeffrey A; Poultsides, George A

2013-05-01

The gastric cancer AJCC/UICC staging system recently underwent significant revisions, but studies on Asian patients have reported a lack of adequate discrimination between various consecutive stages. We sought to validate the new system on a U.S. population database. California Cancer Registry data linked to the Office of Statewide Health Planning and Development discharge abstracts were used to identify patients with gastric adenocarcinoma (esophagogastric junction and gastric cardia tumors excluded) who underwent curative-intent surgical resection in California from 2002 to 2006. AJCC/UICC stage was recalculated based on the latest seventh edition. Overall survival probabilities were calculated using the Kaplan-Meier method. Of 1905 patients analyzed, 54 % were males with a median age of 70 years. Median number of pathologically examined lymph nodes was 12 (range, 1-90); 40 % of patients received adjuvant chemotherapy, and 31 % received adjuvant radiotherapy. The seventh edition AJCC/UICC system did not distinguish outcome adequately between stages IB and IIA (P = 0.40), or IIB and IIIA (P = 0.34). By merging stage II into 1 category and moving T2N1 to stage IB and T2N2, T1N3 to stage IIIA, we propose a new grouping system with improved discriminatory ability In this first study validating the new seventh edition AJCC/UICC staging system for gastric cancer on a U.S. population with a relatively limited number of lymph nodes examined, we found stages IB and IIA, as well as IIB and IIIA to perform similarly. We propose a revised stage grouping for the AJCC/UICC staging system that better discriminates between outcomes.
Migraine, fibromyalgia, and depression among people with IBS: a prevalence study

Directory of Open Access Journals (Sweden)

Cabral Howard J

2006-09-01

Full Text Available Abstract Background Case descriptions suggest IBS patients are more likely to have other disorders, including migraine, fibromyalgia, and depression. We sought to examine the prevalence of these conditions in cohorts of people with and without IBS. Methods The source of data was a large U.S. health plan from January 1, 1996 though June 30, 2002. We identified all people with a medical claim associated with an ICD-9 code for IBS. A non-IBS cohort was a random sample of people with an ICD-9 code for routine medical care. In the cohorts, we identified all claims for migraine, depression, and fibromyalgia. We estimated the prevalence odds ratios (PORs of each of the three conditions using the Mantel-Haenszel method. We conducted quantitative sensitivity analyses to quantify the impact of residual confounding and in differential outcome identification. Results We identified 97,593 people in the IBS cohort, and a random sample of 27,402 people to compose the non-IBS comparison cohort. With adjustment, there was a 60% higher odds in the IBS cohort of having any one of the three disorders relative to the comparison cohort (POR 1.6, 95% CI 1.5 – 1.7. There was a 40% higher odds of depression in the IBS cohort (POR 1.4, 95% CI 1.3 – 1.4. The PORs for fibromyalgia and migraine were similar (POR for fibromyalgia 1.8, 95% CI 1.7 – 1.9; POR for migraine 1.6, 95% CI 1.4 – 1.7. Differential prevalence of an unmeasured confounder, or imperfect sensitivity or specificity of outcome detection would have impacted the observed results. Conclusion People in the IBS cohort had a 40% to 80% higher prevalence odds of migraine, fibromyalgia, and depression.
Does adjuvant therapy improve overall survival for stage IA/B pancreatic adenocarcinoma?

Science.gov (United States)

Ostapoff, Katherine T; Gabriel, Emmanuel; Attwood, Kristopher; Kuvshinoff, Boris W; Nurkin, Steven J; Hochwald, Steven N

2017-07-01

Current guidelines recommend adjuvant chemotherapy for resected pancreatic adenocarcinoma (PDAC). However, no studies have addressed its survival benefit for stage I patients as they comprise IA or IB PDAC were identified. Median OS was 60.3 months (mo) for stage IA and 36.9 mo for IB. 45.5% received adjuvant chemotherapy; 19.9% received adjuvant chemoradiation. There was OS benefit for both stage IA/IB patients with adjuvant chemotherapy (HR = 0.73 and 0.76 for IA and IB, respectively, p = 0.002 and IA disease (n = 1,477, 37.8%), age ≥70 (p < 0.001), higher grade (p < 0.001), ≤10 lymph nodes examined (p = 0.008), positive margins (p < 0.001), and receipt of adjuvant chemoradiation (p = 0.002) were associated with worse OS. For stage IB patients (n = 2,432, 62.2%), similar associations were observed with the exception of adjuvant chemoradiation whereby there was no significant association (p = 0.35). Adjuvant chemotherapy was associated with an OS benefit for patients with stage I PDAC; adjuvant chemoradiation was either of no benefit or associated with worse OS. Copyright © 2017 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.
Effects of ultra-thin Si-fin body widths upon SOI PMOS FinFETs

Science.gov (United States)

Liaw, Yue-Gie; Chen, Chii-Wen; Liao, Wen-Shiang; Wang, Mu-Chun; Zou, Xuecheng

2018-05-01

Nano-node tri-gate FinFET devices have been developed after integrating a 14 Å nitrided gate oxide upon the silicon-on-insulator (SOI) wafers established on an advanced CMOS logic platform. These vertical double gate (FinFET) devices with ultra-thin silicon fin (Si-fin) widths ranging from 27 nm to 17 nm and gate length down to 30 nm have been successfully developed with a 193 nm scanner lithography tool. Combining the cobalt fully silicidation and the CESL strain technology beneficial for PMOS FinFETs was incorporated into this work. Detailed analyses of Id-Vg characteristics, threshold voltage (Vt), and drain-induced barrier lowering (DIBL) illustrate that the thinnest 17 nm Si-fin width FinFET exhibits the best gate controllability due to its better suppression of short channel effect (SCE). However, higher source/drain resistance (RSD), channel mobility degradation due to dry etch steps, or “current crowding effect” will slightly limit its transconductance (Gm) and drive current.
TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib).

Science.gov (United States)

Molinaro, Angelo; Tiosano, Dov; Takatani, Rieko; Chrysis, Dionisios; Russell, William; Koscielniak, Nikolas; Kottler, Marie-Laure; Agretti, Patrizia; De Marco, Giuseppina; Ahtiainen, Petteri; Christov, Marta; Mäkitie, Outi; Tonacchera, Massimo; Jüppner, Harald

2015-05-01

Hypocalcemia and hyperphosphatemia because of resistance toward parathyroid hormone (PTH) in the proximal renal tubules are the most prominent abnormalities in patients affected by pseudohypoparathyroidism type Ib (PHP-Ib). In this rare disorder, which is caused by GNAS methylation changes, resistance can occur toward other hormones, such as thyroid-stimulating hormone (TSH), that mediate their actions through G protein-coupled receptors. However, these additional laboratory abnormalities are usually not recognized until PTH-resistant hypocalcemia becomes clinically apparent. We now describe four pediatric patients, first diagnosed with subclinical or overt hypothyroidism between the ages of 0.2 and 15 years, who developed overt PTH-resistance 3 to 20 years later. Although anti-thyroperoxidase (anti-TPO) antibodies provided a plausible explanation for hypothyroidism in one of these patients, this and two other patients revealed broad epigenetic GNAS abnormalities, which included loss of methylation (LOM) at exons AS, XL, and A/B, and gain of methylation at exon NESP55; ie, findings consistent with PHP-Ib. LOM at GNAS exon A/B alone led in the fourth patient to the identification of a maternally inherited 3-kb STX16 deletion, a well-established cause of autosomal dominant PHP-Ib. Although GNAS methylation changes were not detected in additional pediatric and adult patients with subclinical hypothyroidism (23 pediatric and 39 adult cases), hypothyroidism can obviously be the initial finding in PHP-Ib patients. One should therefore consider measuring PTH, along with calcium and phosphate, in patients with unexplained hypothyroidism for extended periods of time to avoid hypocalcemia and associated clinical complications. © 2014 American Society for Bone and Mineral Research.
FinTech in Norway : the effect of FinTech on the traditional Norwegian banking sector

OpenAIRE

Omreng, Stian; Gjendem, Ida

2017-01-01

The purpose of this thesis is to investigate the effect of FinTech on the Norwegian banking industry. We investigate the drivers of FinTech, the current and potential Norwegian FinTech market, and the international competitiveness of the Norwegian FinTech movement. We identify nine segments of FinTech within the traditional banking functions Financing, Asset management, Payments and Authentication, and we find the key drivers behind the rapid growth of the FinTech market as cha...
Performance study of a fin and tube heat exchanger with different fin geometry

DEFF Research Database (Denmark)

Singh, Shobhana; Sørensen, Kim; Condra, Thomas Joseph

2016-01-01

This study analyses the effect of different fin geometries on the heat transfer and pressure loss characteristics of a fin and tube heat exchanger. A numerical investigation is carried out on liquid–gas type double-finned tube heat exchanger under cross-flow condition. Three different cross......-sections namely: a) Rectangular, b) Trapezoidal, c) Triangular are adopted to define the fin geometry. The CFD simulations are performed to incorporate coupled steady state conjugate heat transfer with the turbulent flow phenomenon for the Reynolds number in the range of 5000-13000. Dimensionless heat transfer...... models show that triangular fin geometry can provide higher heat transfer performance in comparison to the fins with rectangular and trapezoidal geometry with lower pressure loss and a bonus of 7.27% reduction in weight under similar operating conditions....
Flow and Mass Transfer Performance in Short Pin-Fin Channels with Different Fin Shapes

OpenAIRE

Goldstein, R. J.; Chen, S. B.

1998-01-01

The mass transfer (analogous to heat transfer) and pressure loss characteristics of staggered short pin-fin arrays are investigated experimentally in the range of Reynolds number 3000 to 18,000 based on fin diameter and mean approach-flow velocity. Three different shapes of fins with aspect ratio of 2 are examined: one uniform-diameter circular fin (UDCF) and two stepped-diameter circular fins (SDCF1 and SDCF2). Flow visualization using oil-lampblack reveals complex flow characteristics assoc...

Development of a Simulation Model for Swimming with Diving Fins

Directory of Open Access Journals (Sweden)

Motomu Nakashima

2018-02-01

Full Text Available The simulation model to assess the performance of diving fin was developed by extending the swimming human simulation model SWUM. A diving fin was modeled as a series of five rigid plates and connected to the human model by springs and dampers. These plates were connected to each other by virtual springs and dampers, and fin’s bending property was represented by springs and dampers as well. An actual diver’s swimming motion with fins was acquired by a motion capture experiment. In order to determine the bending property of the fin, two bending tests on land were conducted. In addition, an experiment was conducted in order to determine the fluid force coefficients in the fluid force model for the fin. Finally, using all measured and identified information, a simulation, in which the experimental situation was reproduced, was carried out. It was confirmed that the diver in the simulation propelled forward in the water successfully.
IBS and Non-GI Functional Disorders

Science.gov (United States)

... of IBS patients have at least one coexisting somatic symptom and many IBS patients meet diagnostic criteria ... up-to-date on the latest news, stories, tips, research highlights, and more! Sign up for eNewsletter: ...
Endocannabinoid and cannabinoid-like fatty acid amide levels correlate with pain-related symptoms in patients with IBS-D and IBS-C: a pilot study.

Directory of Open Access Journals (Sweden)

Jakub Fichna

Full Text Available AIMS: Irritable bowel syndrome (IBS is a functional gastrointestinal (GI disorder, associated with alterations of bowel function, abdominal pain and other symptoms related to the GI tract. Recently the endogenous cannabinoid system (ECS was shown to be involved in the physiological and pathophysiological control of the GI function. The aim of this pilot study was to investigate whether IBS defining symptoms correlate with changes in endocannabinoids or cannabinoid like fatty acid levels in IBS patients. METHODS: AEA, 2-AG, OEA and PEA plasma levels were determined in diarrhoea-predominant (IBS-D and constipation-predominant (IBS-C patients and were compared to healthy subjects, following the establishment of correlations between biolipid contents and disease symptoms. FAAH mRNA levels were evaluated in colonic biopsies from IBS-D and IBS-C patients and matched controls. RESULTS: Patients with IBS-D had higher levels of 2AG and lower levels of OEA and PEA. In contrast, patients with IBS-C had higher levels of OEA. Multivariate analysis found that lower PEA levels are associated with cramping abdominal pain. FAAH mRNA levels were lower in patients with IBS-C. CONCLUSION: IBS subtypes and their symptoms show distinct alterations of endocannabinoid and endocannabinoid-like fatty acid levels. These changes may partially result from reduced FAAH expression. The here reported changes support the notion that the ECS is involved in the pathophysiology of IBS and the development of IBS symptoms.
Paternal uniparental isodisomy of the entire chromosome 20 as a molecular cause of pseudohypoparathyroidism type Ib (PHP-Ib).

Science.gov (United States)

Bastepe, Murat; Altug-Teber, Ozge; Agarwal, Chhavi; Oberfield, Sharon E; Bonin, Michael; Jüppner, Harald

2011-03-01

Pseudohypoparathyoridism type Ib (PHP-Ib) typically defines the presence of end-organ resistance to parathyroid hormone in the absence of Albright's hereditary osteodystrophy. Patients affected by this disorder present with imprinting defects in the complex GNAS locus. Microdeletions within STX16 or GNAS have been identified in familial cases with PHP-Ib, but the molecular cause of the GNAS imprinting defects in sporadic PHP-Ib cases remains poorly defined. We now report a case with sporadic PHP-Ib for whom a SNPlex analysis revealed loss of the maternal GNAS allele. Further analysis of the entire genome with a 100K SNP chip identified a paternal uniparental isodisomy affecting the entire chromosome 20 without evidence for another chromosomal abnormality. Our findings explain the observed GNAS methylation changes and the patient's hormone resistance, and furthermore suggest that chromosome 20 harbors, besides GNAS, no additional imprinted region that contributes to the clinical and laboratory phenotype. Copyright © 2010 Elsevier Inc. All rights reserved.
Medications (for IBS)

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Full Text Available ... Agents Antidepressant Medications Newer IBS Medications Probiotics and Antibiotics Psychological Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation Techniques for ...
TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib)†

Science.gov (United States)

Molinaro, Angelo; Tiosano, Dov; Takatani, Rieko; Chrysis, Dionisios; Russell, William; Koscielniak, Nikolas; Kottler, Marie-Laure; Agretti, Patrizia; De Marco, Giuseppina; Ahtiainen, Petteri; Christov, Marta; Mäkitie, Outi; Tonacchera, Massimo; Jüppner, Harald

2014-01-01

Hypocalcemia and hyperphosphatemia because of resistance towards parathyroid hormone (PTH) in the proximal renal tubules are the most prominent abnormalities in patients affected by pseudohypoparathyroidism type Ib (PHP-Ib). In this rare disorder that is caused by GNAS methylation changes, resistance can occur towards other hormones, such as thyroid-stimulating hormone (TSH), that mediate their actions through G protein-coupled receptors. However, these additional laboratory abnormalities are usually not recognized until PTH-resistant hypocalcemia becomes clinically apparent. We now describe four pediatric patients, first diagnosed with subclinical or overt hypothyroidism between the ages of 0.2 and 15 years, who developed overt PTH-resistance 3-20 years later. Although anti-TPO antibodies provided a plausible explanation for hypothyroidism in one of these patients, this and two other patients revealed broad epigenetic GNAS abnormalities, which included loss of methylation (LOM) at exons AS, XL and A/B, and gain of methylation at exon NESP55, i.e. findings consistent with PHP-Ib. LOM at GNAS exon A/B alone led in the fourth patient to the identification of a maternally inherited 3-kb STX16 deletion, a well-established cause of autosomal dominant PHP-Ib. Although GNAS methylation changes were not detected in additional pediatric and adult patients with subclinical hypothyroidism (23 pediatric and 39 adult cases), hypothyroidism can obviously be the initial finding in PHP-Ib patients. One should therefore consider measuring PTH, along with calcium and phosphate, in patients with unexplained hypothyroidism for extended periods of time to avoid hypocalcemia and associated clinical complications. PMID:25403028
TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib)†

OpenAIRE

Molinaro, Angelo; Tiosano, Dov; Takatani, Rieko; Chrysis, Dionisios; Russell, William; Koscielniak, Nikolas; Kottler, Marie-Laure; Agretti, Patrizia; De Marco, Giuseppina; Ahtiainen, Petteri; Christov, Marta; Mäkitie, Outi; Tonacchera, Massimo; Jüppner, Harald

2015-01-01

Hypocalcemia and hyperphosphatemia because of resistance towards parathyroid hormone (PTH) in the proximal renal tubules are the most prominent abnormalities in patients affected by pseudohypoparathyroidism type Ib (PHP-Ib). In this rare disorder that is caused by GNAS methylation changes, resistance can occur towards other hormones, such as thyroid-stimulating hormone (TSH), that mediate their actions through G protein-coupled receptors. However, these additional laboratory abnormalities are...
′Belonging without Belonging′: Colm Tóibín′s Dialogue with the Past

DEFF Research Database (Denmark)

Bøss, Michael

2005-01-01

It is argued that Tóibín is not the typical 'revisionist' intellectual that some have made him into, but a humanist and a sort of in-between, making a virtue of his own ambivalences towards notions of tradition, community and nationhood. The essay makes an analysis of these ambivalences with refe......It is argued that Tóibín is not the typical 'revisionist' intellectual that some have made him into, but a humanist and a sort of in-between, making a virtue of his own ambivalences towards notions of tradition, community and nationhood. The essay makes an analysis of these ambivalences...
The pelvic fin and girdle of Panderichthys and the origin of tetrapod locomotion.

Science.gov (United States)

Boisvert, Catherine A

2005-12-22

One of the most marked transformations in the vertebrate transition to land was that of fins to limbs. This transformation involved not only the generation of morphological novelties (digits, sacrum) but also a shift in locomotory dominance from the pectoral to the pelvic appendage. Despite its importance, the transformation from pelvic fin to hindlimb is the least studied and least well-documented part of this transformation, which is bracketed by the osteolepiform Eusthenopteron and the early tetrapods Ichthyostega and Acanthostega, but is not directly illuminated by any intermediate form. Panderichthys is the closest tetrapod relative currently represented by complete fossils, but its pelvic fin skeleton has not been described. Here, I present the only known articulated pelvic fin endoskeleton and associated partial pelvis of Panderichthys. The pelvic girdle is even less tetrapod-like than that of the osteolepiform Eusthenopteron, but the pelvic fin endoskeleton shares derived characteristics with basal tetrapods despite being more primitive than the pectoral fin of Panderichthys. The evolution of tetrapod locomotion appears to have passed through a stage of body-flexion propulsion, in which the pelvic fins played a relatively minor anchoring part, before the emergence of hindlimb-powered propulsion in the interval between Panderichthys and Acanthostega.
Radical surgery for early stage cervical cancer

NARCIS (Netherlands)

Derks, M.

2017-01-01

Cervical cancer is one of the most common malignancies in women worldwide. Due to an effective screening programme, in the Netherlands cervical cancer is often detected in early stages of disease. For early stage (International Federation of Gynaecology and Obstetrics (FIGO) stage IB/IIA) cervical
Fish's Muscles Distortion and Pectoral Fins Propulsion of Lift-Based Mode

Science.gov (United States)

Yang, S. B.; Han, X. Y.; Qiu, J.

As a sort of MPF(median and/or paired fin propulsion), pectoral fins propulsion makes fish easier to maneuver than other propulsion, according to the well-established classification scheme proposed by Webb in 1984. Pectoral fins propulsion is classified into oscillatory propulsion, undulatory propulsion and compound propulsion. Pectoral fins oscillatory propulsion, is further ascribable to two modes: drag-based mode and lift-based mode. And fish exhibits strong cruise ability by using lift-based mode. Therefore to robot fish design using pectoral fins lift-based mode will bring a new revolution to resources exploration in blue sea. On the basis of the wave plate theory, a kinematic model of fish’s pectoral fins lift-based mode is established associated with the behaviors of cownose ray (Rhinoptera bonasus) in the present work. In view of the power of fish’s locomotion from muscle distortion, it would be helpful benefit to reveal the mechanism of fish’s locomotion variation dependent on muscles distortion. So this study puts forward the pattern of muscles distortion of pectoral fins according to the character of skeletons and muscles of cownose ray in morphology and simulates the kinematics of lift-based mode using nonlinear analysis software. In the symmetrical fluid field, the model is simulated left-right symmetrically or asymmetrically. The results qualitatively show how muscles distortion determines the performance of fish locomotion. Finally the efficient muscles distortion associated with the preliminary dynamics is induced.
Streptococcus sanguinis class Ib ribonucleotide reductase: high activity with both iron and manganese cofactors and structural insights.

Science.gov (United States)

Makhlynets, Olga; Boal, Amie K; Rhodes, Delacy V; Kitten, Todd; Rosenzweig, Amy C; Stubbe, JoAnne

2014-02-28

Streptococcus sanguinis is a causative agent of infective endocarditis. Deletion of SsaB, a manganese transporter, drastically reduces S. sanguinis virulence. Many pathogenic organisms require class Ib ribonucleotide reductase (RNR) to catalyze the conversion of nucleotides to deoxynucleotides under aerobic conditions, and recent studies demonstrate that this enzyme uses a dimanganese-tyrosyl radical (Mn(III)2-Y(•)) cofactor in vivo. The proteins required for S. sanguinis ribonucleotide reduction (NrdE and NrdF, α and β subunits of RNR; NrdH and TrxR, a glutaredoxin-like thioredoxin and a thioredoxin reductase; and NrdI, a flavodoxin essential for assembly of the RNR metallo-cofactor) have been identified and characterized. Apo-NrdF with Fe(II) and O2 can self-assemble a diferric-tyrosyl radical (Fe(III)2-Y(•)) cofactor (1.2 Y(•)/β2) and with the help of NrdI can assemble a Mn(III)2-Y(•) cofactor (0.9 Y(•)/β2). The activity of RNR with its endogenous reductants, NrdH and TrxR, is 5,000 and 1,500 units/mg for the Mn- and Fe-NrdFs (Fe-loaded NrdF), respectively. X-ray structures of S. sanguinis NrdIox and Mn(II)2-NrdF are reported and provide a possible rationale for the weak affinity (2.9 μM) between them. These streptococcal proteins form a structurally distinct subclass relative to other Ib proteins with unique features likely important in cluster assembly, including a long and negatively charged loop near the NrdI flavin and a bulky residue (Thr) at a constriction in the oxidant channel to the NrdI interface. These studies set the stage for identifying the active form of S. sanguinis class Ib RNR in an animal model for infective endocarditis and establishing whether the manganese requirement for pathogenesis is associated with RNR.
More negative self-esteem and inferior coping strategies among patients diagnosed with IBS compared with patients without IBS--a case-control study in primary care.

Science.gov (United States)

Grodzinsky, Ewa; Walter, Susanna; Viktorsson, Lisa; Carlsson, Ann-Kristin; Jones, Michael P; Faresjö, Åshild

2015-01-28

Irritable Bowel Syndrome (IBS) is a chronic, relapsing gastrointestinal disorder, that affects approximately 10% of the general population and the majority are diagnosed in primary care. IBS has been reported to be associated with altered psychological and cognitive functioning such as mood disturbances, somatization, catastrophizing or altered visceral interoception by negative emotions and stress. The aim was to investigate the psychosocial constructs of self-esteem and sense of coherence among IBS patients compared to non-IBS patients in primary care. A case-control study in primary care setting among IBS patients meeting the ROME III criteria (n = 140) compared to controls i.e. non-IBS patients (n = 213) without any present or previous gastrointestinal complaints. The data were collected through self-reported questionnaires of psychosocial factors. IBS-patients reported significantly more negative self-esteem (p IBS-cases were also less likely to report 'good' health status (p IBS patients remained statistically significant (p = 0.02), as did the lower scores for sense of coherence among IBS cases (p = 0.04). The more frequently reported negative self-esteem and inferior coping strategies among IBS patients found in this study suggest the possibility that psychological therapies might be helpful for these patients. However these data do not indicate the causal direction of the observed associations. More research is therefore warranted to determine whether these psychosocial constructs are more frequent in IBS patients.
Investigation of material efficient fin patterns for cost-effective operation of fin and tube heat exchanger

DEFF Research Database (Denmark)

Singh, Shobhana; Sørensen, Kim; Condra, Thomas Joseph

2017-01-01

Design management of a thermal energy system is a critical part of identifying basic designs that meet large scale user demand under certain operating characteristics. Fin and tube heat exchangers are among the most commonly used thermal energy systems which are generating considerable interest...... and tube heat exchanger. Computational fluid dynamic models of fin and tube heat exchanger with different fin patterns are developed to investigate the fin pattern behavior on heat transfer and pressure loss performance data. In addition, the numerical results are utilized to analyze the engineering design...... scale-up heat exchanger configurations with each fin pattern focusing on the application of chosen fin and tube heat exchanger in marine exhaust gas boiler. The analysis highlights the impact of material efficient fin patterns investigated and predicts that the polynomial and sinusoidal fin patterns...
A Middle Triassic thoracopterid from China highlights the evolutionary origin of overwater gliding in early ray-finned fishes.

Science.gov (United States)

Xu, Guang-Hui; Zhao, Li-Jun; Shen, Chen-Chen

2015-01-01

Gliding adaptations in thoracopterid flying fishes represent a remarkable case of convergent evolution of overwater gliding strategy with modern exocoetid flying fishes, but the evolutionary origin of this strategy was poorly known in the thoracopterids because of lack of transitional forms. Until recently, all thoracopterids, from the Late Triassic of Austria and Italy and the Middle Triassic of South China, were highly specialized 'four-winged' gliders in having wing-like paired fins and an asymmetrical caudal fin with the lower caudal lobe notably larger than the upper lobe. Here, we show that the new genus Wushaichthys and the previously alleged 'peltopleurid' Peripeltopleurus, from the Middle Triassic (Ladinian, 235-242 Ma) of South China and near the Ladinian/Anisian boundary of southern Switzerland and northern Italy, respectively, represent the most primitive and oldest known thoracopterids. Wushaichthys, the most basal thoracopterid, shows certain derived features of this group in the skull. Peripeltopleurus shows a condition intermediate between Wushaichthys and Thoracopterus in having a slightly asymmetrical caudal fin but still lacking wing-like paired fins. Phylogenetic studies suggest that the evolution of overwater gliding of thoracopterids was gradual in nature; a four-stage adaption following the 'cranial specialization-asymmetrical caudal fin-enlarged paired fins-scale reduction' sequence has been recognized in thoracopterid evolution. Moreover, Wushaichthys and Peripeltopleurus bear hooklets on the anal fin of supposed males, resembling those of modern viviparious teleosts. Early thoracopterids probably had evolved a live-bearing reproductive strategy. © 2015 The Author(s) Published by the Royal Society. All rights reserved.
Stage I carcinoma of the endometrium: Some prognostic factors

International Nuclear Information System (INIS)

Perry, H.; Lefkofsky, M.M.; Chang, H.S.; Mantel, J.

1987-01-01

A total of 446 patients with FIGO stage I adenocarcinoma of the endometrium were treated from 1953 to 1980. The overall actuarial survival was 80.77% at 5 years and 72.16% at 10 years. The 5- and 10-year actuarial survivals for various stages are as follows: stage IA: 82.33% and 73.12%; stage IB: 79.80% and 71.55% (P = .4045); stage IB, grade I: 87l.34% and 79.29%; grade II, 83.11% and 75.52%; grade III, 53.62% and 48.53% (P = .0000); stage IC: for patients receiving preoperative radiation therapy with residual carcinoma in the operative specimen, 86.26% and 79.76%; for specimens containing residual tumor, 76.41% and 68.31% (P = .0802). Patient selection appeared to influence survival
TRAC-PF1/MOD1 independent assessment: Semiscale Mod-2A intermediate break test S-IB-3

International Nuclear Information System (INIS)

Kmetyk, L.N.

1986-02-01

The TRAC-PF1/MOD1 independent assessment project at Sandia National Laboratories is part of an overall effort funded by the NRC to determine the ability of various system codes to predict the detailed thermal/hydraulic response of light water reactors during accident and off-normal conditions. The TRAC code is being assessed at SNLA against test data from various integral and separate effects test facilities. As part of this assessment matrix, an intermediate break test (S-IB-3), performed at the Semiscale Mod-2A facility, has been analyzed. Using an input model with a 3-D VESSEL component, the vessel and downcomer inventories during 3-IB-3 were generally well predicted, but the core heatup was underpredicted compared to data. An equivalent calculation with an all 1-D input model ran about twice as fast as our basecase analysis using a 3-D VESSEL in the input model, but the results of the two calculations diverged significantly for many parameters of interest, with the 3-D VESSEL model results in better agreement with data. 22 refs., 100 figs
The IB Diploma and UK University Degree Qualifications

Science.gov (United States)

Frank-Gemmill, Gerda

2013-01-01

In recent years the International Baccalaureate (IB) Diploma has become widely accepted as a university-entry qualification in the UK, but there has been little quantitative research into the achievements of IB students at degree level. This study investigates IB students from one selective independent school who entered UK universities between…
Thermal performance of circular convective–radiative porous fins with different section shapes and materials

International Nuclear Information System (INIS)

Hatami, M.; Ganji, D.D.

2013-01-01

Graphical abstract: - Highlights: • LSM is an accurate technique for simulating heat transfer in circular porous fins. • Rectangular, convex, triangular and exponential variable sections are considered. • Radiation and convection from porous fin are considered. • Effects of material and geometry on heat transfer from fins are studied. - Abstract: In this study, heat transfer and temperature distribution equations for circular convective–radiative porous fins are presented. It’s assumed that the thickness of circular fins varies with radius so four different shapes, rectangular, convex, triangular and exponential, are considered. The heat transfer through porous media is simulated using passage velocity from the Darcy’s model. After deriving equation for each geometry, Least Square Method (LSM) and fourth order Runge–Kutta method (NUM) are applied for predicting the temperature distribution in the porous fins. The selected porous fin’s materials are Al, SiC, Cu and Si 3 N 4 . Results reveal that LSM has very effective and accurate in comparison with the numerical results. As a main outcome, Si 3 N 4 -exponential section fin has the maximum amount of transferred heat among other fins
Web and Internet-based Capabilities (IbC) Policies - U.S. Department of

Science.gov (United States)

&IIC DCIO IE DCIO R&A DCIO CS In the News Library Contact us Web and Internet-based Capabilities (IbC) Policies Army Navy Air Force Marine Corps General DoD Internet Services and Internet-Based ) Information Collection under the Paperwork Reduction Act (PRA) (OMB Memo) Internet Domain Name and Internet

Studi Analitik dan Numerik Perpindahan Panas pada Fin Trapesium (Studi Kasus pada Finned Tube Heat Exchanger

Directory of Open Access Journals (Sweden)

Ahmad Zaini

2013-09-01

Full Text Available Penambahan fin pada pipa penukar kalor merupakan suatu upaya memperbesar perpindahan kalor konduksi dan konveksi, dengan cara memperluas bidang geometri. Pada penelitian ini dianalisa secara analitik dan numerik perpindahan kalor pada fin dengan profil longitudinal tidak seragam atau berubah terhadap jarak dari dasar fin, dengan memvariasikan ketebalan ujung fin. Hasil dari kedua studi ini tidak jauh berbeda, pada keduanya menjelaskan bahwa fin dengan ketebalan ujung 0,9 mm (fin trapesium terbalik paling baik dari 5 variasi lainnya; serta perubahan temperatur paling besar terjadi pada sepertiga pertama dari panjang fin, ini artinya pelepasan kalor terbesar terjadi pada daerah tersebut. Perbedaannya adalah pada persentase penurunan temperatur sepanjang fin terhadap temperatur dasar fin, untuk ketebalan 0,9 mm pada studi analitik sebesar 91,92% dan pada studi numerik sebesar 91,78%. Hal ini berarti metode penyelesaian persamaan diferensial orde 2 dengan koefisien variabel dengan cara pembedahan koefisien variabel pada ODE, sudah benar dan valid. Namun bila ditinjau dari waktu yang diperlukan untuk komputasinya, studi analitik membutuhkan waktu lebih lama. Waktu yang diperlukan dalam komputasinya tergantung dari fungsi koefisien variabel.
Open Channel Natural Convection Heat Transfer on a Vertical Finned Plate

International Nuclear Information System (INIS)

Park, Joo Hyun; Heo, Jeong Hwan; Chung, Bum Jin

2013-01-01

The natural convection heat transfer of vertical plate fin was investigated experimentally. Heat transfer systems were replaced by mass-transfer systems, based on the analogy concept. The experimental results lie within the predictions of the existing heat transfer correlations of plate-fin for the natural convections. An overlapped thermal boundary layers caused increasing heat transfer, and an overlapped momentum boundary layers caused decreasing heat transfer. As the fin height increases, heat transfer was enhanced due to increased inflow from the open side of the fin spacing. When fin spacing and fin height are large, heat transfer was unaffected by the fin spacing and fin height. Passive cooling by natural convection becomes more and more important for the nuclear systems as the station black out really happened at the Fukushima NPPs. In the RCCS (Reactor Cavity Cooling System) of a VHTR (Very High Temperature Reactor), natural convection cooling through duct system is adopted. In response to the stack failure event, extra cooling capacity adopting the fin array has to be investigated. The finned plate increases the surface area and the heat transfer increases. However, the plate of fin arrays may increase the pressure drop and the heat transfer decreases. Therefore, in order to enhance the passive cooling with fin arrays, the parameters for the fin arrays should be optimized. According to Welling and Wooldridge, a natural convection on vertical plate fin is function of Gr, Pr, L, t, S, and H. The present work investigated the natural convection heat transfer of a vertical finned plate with varying the fin height and the fin spacing. In order achieve high Rayleigh numbers, an electroplating system was employed and the mass transfer rates were measured using a copper sulfate electroplating system based on the analogy concept
Integrated Baseline Bystem (IBS) Version 1.03: Models guide

Energy Technology Data Exchange (ETDEWEB)

1993-01-01

The Integrated Baseline System)(IBS), operated by the Federal Emergency Management Agency (FEMA), is a system of computerized tools for emergency planning and analysis. This document is the models guide for the IBS and explains how to use the emergency related computer models. This document provides information for the experienced system user, and is the primary reference for the computer modeling software supplied with the system. It is designed for emergency managers and planners, and others familiar with the concepts of computer modeling. Although the IBS manual set covers basic and advanced operations, it is not a complete reference document set. Emergency situation modeling software in the IBS is supported by additional technical documents. Some of the other IBS software is commercial software for which more complete documentation is available. The IBS manuals reference such documentation where necessary.
Medications (for IBS)

Medline Plus

Full Text Available ... IBS Medications Probiotics and Antibiotics Psychological ... With Your Doctor Successful relationships with healthcare providers are an important part of managing life with a long-term digestive disorder. Working with ...
Experience with IBS-suppression lattice in RHIC

International Nuclear Information System (INIS)

Litvinenko, V.N.; Luo, Y.; Ptitsyn, V.; Satogata, T.; Tepikian, S.; Bai, M.; Bruno, D.; Cameron, P.; Connolly, R.; Della Penna, A.; Drees, A.; Fedotov, A.; Ganetis, G.; Hoff, L.; Louie, W.; Malitsky, N.; Marr, G.; Marusic, A.; Montag, C.; Pilat, F.; Roser, T.; Trbojevic, D.; Tsoupas, N.

2008-01-01

An intra-beam scattering (IBS) is the limiting factor of the luminosity lifetime for RHIC operating with heavy ions. In order to suppress the IBS we designed and implemented new lattice with higher betatron tunes. This lattice had been developed during last three years and had been used for gold ions in yellow ring of the RHIC during d-Au part of the RHIC Run-8. The use of this lattice allowed both significant increases in the luminosity lifetime and the luminosity levels via reduction of beta-stars in the IPS. In this paper we report on the development, the tests and the performance of IBS-suppression lattice in RHIC, including the resulting increases in the peak and the average luminosity. We also report on our plans for future steps with the IBS suppression
"STUDY OF CONCURRENT CISPLATIN AND EXTERNAL RADIOTHERAPY PRIOR TO RADICAL HYSTERECTOMY AND LYMPHADENECTOMY IN PATIENTS WITH STAGE IB-IIB CERVICAL CANCER"

Directory of Open Access Journals (Sweden)

M. Modares Gilani

2004-06-01

Full Text Available The purpose of this study was to describe the feasibility of a combined preoperative chemoradiation program Ib-IIa, bulky and suspicious IIb by radical surgery in patients with stage Ib-IIb cervical cancer. From September 1999 to April 2002, 30 patients with carcinoma of the cervix were treated with preoperative external beam radiotherapy of 45 Gy in 5 weeks. Patients received concurrent continuous infusion of cisplatin 50 mg/m2 for one day in week during 5 weeks of radiation. Radical surgery was performed 4-6 weeks after completion of the preoperative treatment. Toxicity with chemoradiation was usually mild. Two patients developed vesicovaginal fistula, and four developed long-term hydronephrosis that needed ureteral stenting. Clinical response was observed in 100% of the patients (23.7% complete response. The analysis of the surgical specimens revealed complete pathological response in 43.3% of the cases and partial pathological response in 56.7%. The degree of pathological response was not predictable by the degree of clinical response. Thirty months disease-free survival and overall survival were 66.3% and 77.31%, respectively. Patients with complete and partial pathological response were not significantly different in terms of disease-free survival (p= 0.08 and overall survival (p= 0.3. Cisplatin in preoperative chemoradiation is effective and usually welltolerated in bulky cervical cancer and parametrial invasion, inducing a high rate of clinical and pathological complete responses. When this therapy is followed by radical surgery, disease-free and overall survival rates are higher. The latter may be possible only through extensive surgical resection with a parallel increase in complication rates.
A review on the current issues and barriers of Industrialised Building System (IBS) adoption in Malaysia’s construction industry

Science.gov (United States)

Amin, M. A. Mohd; Abas, N. H.; Shahidan, S.; Rahmat, M. H.; Suhaini, N. A.; Nagapan, S.; Rahim, R. Abdul

2017-11-01

Malaysia considers the construction industry as one of the main contributors to its Gross Domestic Product (GDP). However, there are some unresolved issues arising from the ongoing and widespread adoption of the conventional method of construction such as the resultant fragmentation of the industry itself; delays in production and delivery time of unnecessary wastages and lack of sustainability practice. Malaysian Government has been continuously encouraging the industry to use, partly or if not wholly, the Industrialized Building System (IBS), which is considered to be an important part of sustainable construction initiative. IBS was introduced to Malaysia as the solution to issues related to dependencies of foreign workers, raising demand for affordable accommodations and improving image, quality and productivity of construction industry. However, the IBS adoption in Malaysia remains low. This paper presents the review of the current issues and barriers of IBS adoption in Malaysian construction industry.
High performance flexible CMOS SOI FinFETs

KAUST Repository

Fahad, Hossain M.

2014-06-01

We demonstrate the first ever CMOS compatible soft etch back based high performance flexible CMOS SOI FinFETs. The move from planar to non-planar FinFETs has enabled continued scaling down to the 14 nm technology node. This has been possible due to the reduction in off-state leakage and reduced short channel effects on account of the superior electrostatic charge control of multiple gates. At the same time, flexible electronics is an exciting expansion opportunity for next generation electronics. However, a fully integrated low-cost system will need to maintain ultra-large-scale-integration density, high performance and reliability - same as today\\'s traditional electronics. Up until recently, this field has been mainly dominated by very weak performance organic electronics enabled by low temperature processes, conducive to low melting point plastics. Now however, we show the world\\'s highest performing flexible version of 3D FinFET CMOS using a state-of-the-art CMOS compatible fabrication technique for high performance ultra-mobile consumer applications with stylish design. © 2014 IEEE.
Medications (for IBS)

Medline Plus

Full Text Available ... Read more about antidiarrheal agents. Anti-anxiety medications – can be helpful for some people with IBS, mainly those with emotional distress. There are also effective medications available that relieve ...
Toward quantum FinFET

CERN Document Server

Wang, Zhiming

2013-01-01

This book reviews a range of quantum phenomena in novel nanoscale transistors called FinFETs, including quantized conductance of 1D transport, single electron effect, tunneling transport, etc. The goal is to create a fundamental bridge between quantum FinFET and nanotechnology to stimulate readers' interest in developing new types of semiconductor technology. Although the rapid development of micro-nano fabrication is driving the MOSFET downscaling trend that is evolving from planar channel to nonplanar FinFET, silicon-based CMOS technology is expected to face fundamental limits in the near future. Therefore, new types of nanoscale devices are being investigated aggressively to take advantage of the quantum effect in carrier transport. The quantum confinement effect of FinFET at room temperatures was reported following the breakthrough to sub-10nm scale technology in silicon nanowires. With chapters written by leading scientists throughout the world, Toward Quantum FinFET provides a comprehensive introductio...
Computational investigation of heat transfer and pressure drop in a typical louver fin-and-tube heat exchanger for various louver angles and fin pitches

Directory of Open Access Journals (Sweden)

Okbaz Abdulkerim

2017-01-01

Full Text Available In this study 3-D numerical simulations on heat transfer and pressure drop characteristics for a typical louver fin-and- double-row tube heat exchanger were carried out. The heat transfer improvement and the corresponding pressure drop amounts were investigated depending on louver angles, fin pitch and Reynolds number, and reported in terms of Colburn j-factor and Fanning friction factor f. The heat transfer improvement and the corresponding pressure drop amounts were investigated depending on louver angles between 20° ≤Ө≤ 30°, louver pitch of Lp=3.8 mm and frontal velocities of U between 1.22 m/s - 3 m/s. In addition, flow visualization of detailed flow features results, such as velocity vectors, streamlines and temperature counters have been shown to understand heat transfer enhancement mechanism. The present results indicated that louver angle and fin pitch noticeably affected the thermal and hydraulic performance of heat exchanger. It has been seen that increasing louver angle, increases thermal performance while decreasing hydraulic performance associated to pressure drop for fin pitches of 3.2 mm and 2.5 mm. Fin pitch determines the flow behaviour that for fin pitch of 2 mm, increasing louver angle decreased heat transfer and pressure drop. Velocity vectors and streamlines give considerable information about the flow whether it is duct directed or louver directed. For all conditions the flow is louver directed.
Platelet Glycoprotein Ib-IX and Malignancy

Science.gov (United States)

2010-09-01

provide a unique microenvironment supporting the accumulation of more platelets and the elaboration of a fibrin - rich network produced by coagulation...process and can initiate the formation of a platelet - rich thrombus by tethering the platelet to a thrombogenic surface. Several ligands binding to GP Ib... Platelet Glycoprotein Ib-IX and Malignancy PRINCIPAL INVESTIGATOR: Jerry Ware, Ph.D
Translation and validation of a Japanese version of the irritable bowel syndrome-quality of life measure (IBS-QOL-J

Directory of Open Access Journals (Sweden)

Hongo Michio

2007-03-01

Full Text Available Abstract Aims To compare quality of life (QOL for patients with irritable bowel syndrome (IBS between the U.S. and Japan, it is indispensable to develop common instruments. The IBS-QOL, which is widely used in Western countries, was translated into Japanese as there has been a lack of Japanese disease-specific QOL measures for IBS. Methods The original 34 items of the IBS-QOL were translated from English into Japanese through two independent forward translations, resolution, back translation, and resolution of differences. Forty nine patients who had GI symptoms but did not have any organic diseases (including 30 IBS patients diagnosed by Rome II criteria were recruited from Tohoku University Hospital in Sendai, Japan and completed a Japanese version of the IBS-QOL (IBS-QOL-J concomitant with a Japanese version of the IBS severity index (IBSSI-J twice within 7–14 days. Results The IBS-QOL-J demonstrated high internal consistency (Cronbach's alpha; 0.96 and high reproducibility (intraclass correlation coefficient; 0.92, p Conclusion The IBS-QOL-J is a reliable instrument to assess the disease-specific QOL for IBS. Considering cross-cultural comparison, this measure is likely to be a valuable tool to investigate the QOL in Japanese patients with IBS.
A CMMS Expert using BIM for IBS Building Maintenance

Directory of Open Access Journals (Sweden)

Hamzah Noraini

2016-01-01

Full Text Available In the IBS building maintenance, the conventional methods to the project delivery and its failure to form effective communication channel between complementary knowledge on IBS construction and related members that is conducted in the sequential manner has resulted in ineffectiveness for managing building maintenance, where a paradigm shift within the IBS traditional approach is necessary. The research results described are concerned with i an integrated system to record, diagnose and analyse information for IBS building maintenance to detect patent or latent defect, select an effective repair method, provide appropriate planning decision and reduce risks of defect throughout the building lifetime. ii building a decision making support in diagnosis in IBS building maintenance based on robust data collection about concrete defects and causes including in the selection of a durable replacement design and material or the proper rehabilitation method. The system development was based on analysis of number of interviews and case studies conducted with professional engineers working in IBS building maintenance departments. The paper concludes that implementing a CMMS Expert using BIM can help improve the performance of IBS building design, construction and maintenance operations.
Adjuvant radiotherapy following radical hysterectomy for patients with stage IB and IIA cervical cancer

Energy Technology Data Exchange (ETDEWEB)

Soisson, A.P.; Soper, J.T.; Clarke-Pearson, D.L.; Berchuck, A.; Montana, G.; Creasman, W.T. (Duke Univ. Medical Center, Durham, NC (USA))

1990-06-01

From 1971 through 1984, 320 women underwent radical hysterectomy as primary therapy of stage IB and IIA cervical cancer. Two hundred forty-eight patients (78%) were treated with surgery alone and 72 patients (22%) received adjuvant postoperative external-beam radiotherapy. Presence of lymph node metastasis, large lesion (greater than 4 cm in diameter), histologic grade, race (noncaucasian), and age (greater than 40 years) were significant poor prognostic factors for the entire group of patients. Patients treated with surgery alone had a better disease-free survival than those who received combination therapy (P less than 0.001). However, patients receiving adjuvant radiation therapy had a higher incidence of lymphatic metastases, tumor involvement of the surgical margin, and large cervical lesions. Adjuvant pelvic radiation therapy did not improve the survival of patients with unilateral nodal metastases or those who had a large cervical lesion with free surgical margins and the absence of nodal involvement. Radiation therapy appears to reduce the incidence of pelvic recurrences. Unfortunately, 84% of patients who developed recurrent tumor after combination therapy had a component of distant failure. The incidence of severe gastrointestinal or genitourinary tract complications was not different in the two treatment groups. However, the incidence of lymphedema was increased in patients who received adjuvant radiation therapy. Although adjuvant radiation therapy appears to be tolerated without a significant increase in serious complications, the extent to which it may improve local control rates and survival in high-risk patients appears to be limited. In view of the high incidence of distant metastases in high-risk patients, consideration should be given to adjuvant systemic chemotherapy in addition to radiation therapy.
Impact of Channel, Stress-Relaxed Buffer, and S/D Si1- x Ge x Stressor on the Performance of 7-nm FinFET CMOS Design with the Implementation of Stress Engineering

Science.gov (United States)

Othman, Nurul Aida Farhana; Hatta, Sharifah Fatmadiana Wan Muhamad; Soin, Norhayati

2018-04-01

Stress-engineered fin-shaped field effect transistors (FinFET) using germanium (Ge) is a promising performance booster to replace silicon (Si) due to its high holes mobility. This paper presents a three-dimensional simulation by the Sentaurus technology computer-aided design to study the effects of stressors—channel stress, stress-relaxed buffer (SRB), and source/drain (S/D) epitaxial stress—on different bases of FinFET, specifically silicon germanium (SiGe) and Ge-based, whereby the latter is achieved by manipulating the Ge mole fraction inside the three layers; their effects on the devices' figures-of-merits were recorded. The simulation generates an advanced calibration process, by which the drift diffusion simulation was adopted for ballistic transport effects. The results show that current enhancement in p-type FinFET (p-FinFET) with 110% is almost twice that in n-type FinFET (n-FinFET) with 57%, with increasing strain inside the channel suggesting that the use of strain is more effective for holes. In SiGe-based n-FinFET, the use of a high-strained SRB layer can improve the drive current up to 112%, while the high-strain S/D epitaxial for Ge-based p-FinFET can enhance the on-state current to 262%. Further investigations show that the channel and S/D doping are affecting the performances of SiGe-based FinFET with similar importance. It is observed that doping concentrations play an important role in threshold voltage adjustment as well as in drive current and subthreshold leakage improvements.
Correlated evolution of body and fin morphology in the cichlid fishes.

Science.gov (United States)

Feilich, Kara L

2016-10-01

Body and fin shapes are chief determinants of swimming performance in fishes. Different configurations of body and fin shapes can suit different locomotor specializations. The success of any configuration is dependent upon the hydrodynamic interactions between body and fins. Despite the importance of body-fin interactions for swimming, there are few data indicating whether body and fin configurations evolve in concert, or whether these structures vary independently. The cichlid fishes are a diverse family whose well-studied phylogenetic relationships make them ideal for the study of macroevolution of ecomorphology. This study measured body, and caudal and median fin morphology from radiographs of 131 cichlid genera, using morphometrics and phylogenetic comparative methods to determine whether these traits exhibit correlated evolution. Partial least squares canonical analysis revealed that body, caudal fin, dorsal fin, and anal fin shapes all exhibited strong correlated evolution consistent with locomotor ecomorphology. Major patterns included the evolution of deep body profiles with long fins, suggestive of maneuvering specialization; and the evolution of narrow, elongate caudal peduncles with concave tails, a combination that characterizes economical cruisers. These results demonstrate that body shape evolution does not occur independently of other traits, but among a suite of other morphological changes that augment locomotor specialization. © 2016 The Author(s). Evolution © 2016 The Society for the Study of Evolution.
Medications (for IBS)

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Full Text Available ... be taken on a more long-term basis. These include low dose antidepressant agents or the relatively ... IBS in multi-center, high quality clinical trials. These are prescription medications intended for specific use under ...
Medications (for IBS)

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Full Text Available ... Beth Israel Deaconess Medical Center, Boston, MA. Last modified on February 23, 2015 at 12:18:55 ... Dietary Fiber 12 Week Elimination Diet for IBS Rice-Based Foods Low-FODMAP Diet What Are FODMAPs? ...
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Full Text Available ... for some people with IBS, mainly those with emotional distress. There are also effective medications available that ... not linked to depression, but rather likely to effects on the brain and the gut. Antidepressant medications ...

Medications (for IBS)

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Full Text Available ... have limited benefit for treating IBS. In some persons they relieve abdominal pain or discomfort, usually if ... Summary The effectiveness of various agents differs between individuals. A medication regimen must be carefully chosen by ...
Medications (for IBS)

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Full Text Available ... He or she can help you monitor quality, effectiveness, possible interactions with other medicines you may be ... Read more about newer IBS medications. Summary The effectiveness of various agents differs between individuals. A medication ...
Medications (for IBS)

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Full Text Available ... Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in irritable bowel syndrome ( ... limited by prescription only. It might be a drug or a supplement; manufactured or "natural." It might ...
Medications (for IBS)

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Full Text Available ... Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in irritable bowel syndrome ( ... take for a therapeutic effect counts as a medicine. It can be readily available over-the-counter, ...
Medications (for IBS)

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Full Text Available ... Help You? IFFGD is a nonprofit education and research organization. Our mission is to inform, assist, and ... About IFFGD Our Mission Awareness Activities Advocacy Activities Research Leadership Industry Council Contact us IBS Treatment Working ...
Medications (for IBS)

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Full Text Available ... for some people with IBS, mainly those with emotional distress. There are also effective medications available that ... This Article Help You? IFFGD is a nonprofit education and research organization. Our mission is to inform, ...
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Full Text Available ... effective medications available that relieve the pain and improve the changes in bowel habit. They may need ... effective in treating IBS in multi-center, high quality clinical trials. These are prescription medications intended for ...
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Full Text Available ... J. Lembo, MD, Instructor of Medicine, Harvard Medical School; Division of Gastroenterology, Beth Israel Deaconess Medical Center, ... About IFFGD Our Mission Awareness Activities Advocacy Activities Research Leadership Industry Council Contact us IBS Treatment Working ...
Medications (for IBS)

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Full Text Available ... do not respond to physician counseling and dietary manipulations. What's a medication? Anything you take for a ... Psychological Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation Techniques for IBS Take Part in Online Studies Working ...
Medications (for IBS)

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Full Text Available ... You? IFFGD is a nonprofit education and research organization. Our mission is to inform, assist, and support ... IFFGD Our Mission Awareness Activities Advocacy Activities Research Leadership Industry Council Contact us IBS Treatment Working With ...
Medications (for IBS)

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Full Text Available ... MA. Last modified on February 23, 2015 at 12:18:55 PM Treatment Understanding and Managing Pain ... Foods that Cause Gas and Bloating Dietary Fiber 12 Week Elimination Diet for IBS Rice-Based Foods ...
Medications (for IBS)

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Full Text Available ... depression, but rather likely to effects on the brain and the gut. Antidepressant medications can reduce the intensity of pain signals going from gut to brain. Read more about antidepressant medications. Newer IBS-Targeted ...
Medications (for IBS)

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Full Text Available ... discomfort, usually if the symptoms occur soon after eating. Examples include dicyclomine (Bentyl), and hyoscyamine (Levsin). Read ... treatment of IBS symptoms is not linked to depression, but rather likely to effects on the brain ...
Medications (for IBS)

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Full Text Available ... severe symptoms which do not respond to physician counseling and dietary manipulations. What's a medication? Anything you ... Therapy Relaxation Techniques for IBS Take Part in Online Studies Working With Your Doctor Successful relationships with ...
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Full Text Available ... it. He or she can help you monitor quality, effectiveness, possible interactions with other medicines you may ... effective in treating IBS in multi-center, high quality clinical trials. These are prescription medications intended for ...
PHASE CHANGE AROUND A FINNED TUBE

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Aytunç EREK

2003-01-01

Full Text Available This study presents the heat transfer enhancement in the thermal energy storage system by using radially finned tube. The solution of the system consists of the solving the equations of the heat transfer fluid (HTF, the pipe wall and fin, and the phase change material (PCM as one domain. The control volume finite difference approach and the semi implicit solver (SIS are used to solve the equations. Fully developed velocity distribution is taken in the HTF. Flow parameters (Re number and inlet temperature of coolant and fin parameters (the number of fins, fin length, fin thickness are found to influence solidification fronts and the total stored energy.
FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial.

Science.gov (United States)

McIntosh, Keith; Reed, David E; Schneider, Theresa; Dang, Frances; Keshteli, Ammar H; De Palma, Giada; Madsen, Karen; Bercik, Premysl; Vanner, Stephen

2017-07-01

To gain mechanistic insights, we compared effects of low fermentable oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high FODMAP diets on symptoms, the metabolome and the microbiome of patients with IBS. We performed a controlled, single blind study of patients with IBS (Rome III criteria) randomised to a low (n=20) or high (n=20) FODMAP diet for 3 weeks. Symptoms were assessed using the IBS symptom severity scoring (IBS-SSS). The metabolome was evaluated using the lactulose breath test (LBT) and metabolic profiling in urine using mass spectrometry. Stool microbiota composition was analysed by 16S rRNA gene profiling. Thirty-seven patients (19 low FODMAP; 18 high FODMAP) completed the 3-week diet. The IBS-SSS was reduced in the low FODMAP diet group (pmetabolome. In subsets of patients, FODMAPs modulate histamine levels and the microbiota, both of which could alter symptoms. NCT01829932. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
Stages of Adult Soft Tissue Sarcoma

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... deep (in the muscle and may be in connective or subcutaneous tissue). In stage IB , the tumor is low-grade (likely to grow and spread ... deep (in the muscle and may be in connective or subcutaneous tissue). In stage IIB , the tumor is mid-grade (somewhat likely to grow and ...
Medications (for IBS)

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Full Text Available ... your doctor about it. He or she can help you monitor quality, effectiveness, possible interactions with other ... effectively treat multiple symptoms of IBS. Laxatives – can help treat symptoms of constipation. Laxatives should be used ...
Medications (for IBS)

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Full Text Available ... include bran or psyllium. Anticholinergics/Antispasmodics – have limited benefit for treating IBS. In some persons they relieve ... This Article Help You? IFFGD is a nonprofit education and research organization. Our mission is to inform, ...

Channels with Different Fin Shapes

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R. J. Goldstein

1998-01-01

Full Text Available The mass transfer (analogous to heat transfer and pressure loss characteristics of staggered short pin-fin arrays are investigated experimentally in the range of Reynolds number 3000 to 18,000 based on fin diameter and mean approach-flow velocity. Three different shapes of fins with aspect ratio of 2 are examined: one uniform-diameter circular fin (UDCF and two stepped-diameter circular fins (SDCF1 and SDCF2. Flow visualization using oil-lampblack reveals complex flow characteristics associated with the repeated production of horseshoe vortices and fin wakes, and the interactions among these. The SDCF1 and SDCF2 arrays show flow characteristics different from the UDCF array due to downflow from the steps. For all arrays tested, the near-endwall flow varies row by row in the initial rows until it reaches a stable pattern after the third row. The row-averaged Sherwood numbers obtained from the naphthalene sublimation experiment also show a row-by-row variation pattern similar to the flow results. While the SDCF2 array has the highest mass transfer rate, the SDCF1 array has the smallest pressure loss at the same approach-flow velocity. The fin surfaces have higher array-averaged Sherwood number than the endwall and the ratio between these changes with fin shape and Reynolds number. The performance of the pin-fin arrays is analyzed under two different constraints: the mass[heat transfer rate at fixed pumping power, and the mass/heat transfer area and pressure loss to fulfill fixed heat load at a fixed mass flow rate. In both cases, the SDCF2 array shows the best performance.
Prácticas rituales ibéricas en La Cueva del Sapo (Chiva, Valencia: más allá del caliciforme

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Sonia MACHAUSE LÓPEZ

2015-01-01

Full Text Available Se presentan los resultados del estudio interdisciplinar del yacimiento ibérico de la Cueva del Sapo (Chiva, Valencia. Las características del conjunto estudiado muestran un contexto ritual que sería frecuentado entre los SS. V-II a. C. La diversidad cronológica y material así como el volumen de restos indican la existencia de varias actividades rituales intermitentes, no generalizadas y que se suceden en el tiempo. Nos acercamos a ellas a través de la presencia de restos de fauna, con escasas evidencias de consumo que reflejan un ritual principal en torno a la figura del ciervo, huesos humanos sin incinerar con marcas que demuestran un tratamiento concreto del cadáver ligado a un complejo ritual funerario en época ibérica y otros materiales –cerámicas, metales y carbones– que también son pruebas de una actividad ritual en la cueva, cuyas características difieren de los criterios tradicionales establecidos para las cuevas con materiales ibéricos. Todos estos factores nos hacen replantearnos la definición tradicional, todavía vigente, para este tipo de contextos rituales, cargada en algunas ocasiones de excesivas generalizaciones.
The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome.

Science.gov (United States)

Garrity, Deborah M; Childs, Sarah; Fishman, Mark C

2002-10-01

Holt-Oram syndrome is one of the autosomal dominant human "heart-hand" disorders, with a combination of upper limb malformations and cardiac defects. Holt-Oram syndrome is caused by mutations in the TBX5 gene, a member of a large family of T-box transcription factors that play important roles in cell-type specification and morphogenesis. In a screen for mutations affecting zebrafish cardiac function, we isolated the recessive lethal mutant heartstrings, which lacks pectoral fins and exhibits severe cardiac dysfunction, beginning with a slow heart rate and progressing to a stretched, non-functional heart. We mapped and cloned the heartstrings mutation and find it to encode the zebrafish ortholog of the TBX5 gene. The heartstrings mutation causes premature termination at amino acid 316. Homozygous mutant embryos never develop pectoral fin buds and do not express several markers of early fin differentiation. The total absence of any fin bud differentiation distinguishes heartstrings from most other mutations that affect zebrafish fin development, suggesting that Tbx5 functions very early in the pectoral fin induction pathway. Moderate reduction of Tbx5 by morpholino causes fin malformations, revealing an additional early requirement for Tbx5 in coordinating the axes of fin outgrowth. The heart of heartstrings mutant embryos appears to form and function normally through the early heart tube stage, manifesting only a slight bradycardia compared with wild-type siblings. However, the heart fails to loop and then progressively deteriorates, a process affecting the ventricle as well as the atrium. Relative to mammals, fish require lower levels of Tbx5 to produce malformed appendages and display whole-heart rather than atrial-predominant cardiac defects. However, the syndromic deficiencies of tbx5 mutation are remarkably well retained between fish and mammals.
Critical Success Factors for Lean Thinking in the Application of Industrialised Building System (IBS)

Science.gov (United States)

Yunus, Riduan; Noor, Siti Rahimah Mohd; Halid Abdullah, Abd; Nagapan, Sasitharan; Hamid, Abdul Rahim Abdul; Tajudin, Saiful Azhar Ahmad; Rohani Mat Jusof, Siti

2017-08-01

Productivity in the manufacturing process of building components can be increased by optimising each advantage that is available in each activity. Identification of critical success factors (CSFs) for lean thinking in the Industrialised Building System (IBS) will be able to minimise cost and reduce time needed to complete a project. The focus of lean thinking in construction is on the production process and the client’s requirement. In developing countries such as Malaysia, the integration of lean thinking in IBS applications is still low and there is a shortage of comprehensive strategies to integrate lean thinking. As key stakeholders, feedback from contractors, manufacturers, developers and the local authority will be able to help the identification of CSFs in integrating lean thinking in IBS applications. The data was collected through a questionnaire survey and analysed quantitatively. There are 31 CSFs for lean thinking in IBS which have been identified in this study. A conceptual model was developed to assist researchers in investigating the influences of CSFs for lean thinking in IBS applications. This study will assist construction players to improvise their manufacturing process in the implementation of IBS to eliminate unnecessary activities and focus instead on significant processes without generating physical and non-physical waste.
Overcoming ICT Barriers in IBS Management Process in Malaysia Construction Industry

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Soon Ern Peniel Ang

2017-01-01

Full Text Available As the result of government’s initiative and future outlook in uprising the awareness towards the implementation of sustainable elements in construction industries, the Industrialized Building System (IBS is one of the approaches that had been introduced as an alternative to conventional building method and produce the new strategy of reducing the waste of materials in construction. The IBS approach is actively promoted through several strategies and incentives as an alternative to conventional building methods. Extensive uptakes of modern Information Communication Technology (ICT applications are able to support the different IBS processes for effective production. However, it is argued that ICT uptake at the organizational level needs to be regularly improved. Thus, this paper fulfills the need to identify the critical barriers to ICT employment and highlighting the ICT drivers in enhancing the IBS management process. Critical barriers and drivers to ICT uptake were identified through questionnaire survey with industry stakeholders and were analyzed using mean index and critical t-value with the use of SPSS software. The critical drivers are top management support and commitment and improving the availability of the technologies. The critical drivers which were identified are significant in ensuring the enhancement of ICT implementation. Hence, any system in place should avoid the highest ranked barriers or seek to alleviate their impact by focusing on the identified drivers in order to enhance implementation of ICT in IBS process management.
Enhanced accumulation of carotenoids in sweetpotato plants overexpressing IbOr-Ins gene in purple-fleshed sweetpotato cultivar.

Science.gov (United States)

Park, Sung-Chul; Kim, Sun Ha; Park, Seyeon; Lee, Hyeong-Un; Lee, Joon Seol; Park, Woo Sung; Ahn, Mi-Jeong; Kim, Yun-Hee; Jeong, Jae Cheol; Lee, Haeng-Soon; Kwak, Sang-Soo

2015-01-01

Sweetpotato [Ipomoea batatas (L.) Lam] is an important root crop that produces low molecular weight antioxidants such as carotenoids and anthocyanin. The sweetpotato orange (IbOr) protein is involved in the accumulation of carotenoids. To increase the levels of carotenoids in the storage roots of sweetpotato, we generated transgenic sweetpotato plants overexpressing IbOr-Ins under the control of the cauliflower mosaic virus (CaMV) 35S promoter in an anthocyanin-rich purple-fleshed cultivar (referred to as IbOr plants). IbOr plants exhibited increased carotenoid levels (up to 7-fold) in their storage roots compared to wild type (WT) plants, as revealed by HPLC analysis. The carotenoid contents of IbOr plants were positively correlated with IbOr transcript levels. The levels of zeaxanthin were ∼ 12 times elevated in IbOr plants, whereas β-carotene increased ∼ 1.75 times higher than those of WT. Quantitative RT-PCR analysis revealed that most carotenoid biosynthetic pathway genes were up-regulated in the IbOr plants, including PDS, ZDS, LCY-β, CHY-β, ZEP and Pftf, whereas LCY-ɛ was down-regulated. Interestingly, CCD1, CCD4 and NCED, which are related to the degradation of carotenoids, were also up-regulated in the IbOr plants. Anthocyanin contents and transcription levels of associated biosynthetic genes seemed to be altered in the IbOr plants. The yields of storage roots and aerial parts of IbOr plants and WT plants were not significantly different under field cultivation. Taken together, these results indicate that overexpression of IbOr-Ins can increase the carotenoid contents of sweetpotato storage roots. Copyright © 2014 Elsevier Masson SAS. All rights reserved.
Functional Expression of a DNA-Topoisomerase IB from Cryptosporidium parvum

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César Ordóñez

2009-01-01

Full Text Available Cryptosporidium parvum, one of the most important causative organisms of human diarrheas during childhood, contains a monomeric DNA-topoisomerase IB (CpTopIB in chromosome 7. Heterologous expression of CpTopIB gene in a budding yeast strain lacking this activity proves that the cryptosporidial enzyme is functional in vivo. The enzymatic activity is comprised in a single polypeptide, which contains all the structural features defining a fully active TopIB. Relaxation activity of the yeast extracts was detected only when CpTopIB ORF was expressed in a yeast expression system showing time and protein dependence under steady state kinetic conditions. The susceptibility of CpTopIB-transformed yeast to the irreversible inhibitor camptothecin and its water-soluble derivatives (topotecan and SN-38 was assessed.
Medications (for IBS)

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Full Text Available ... include bran or psyllium. Anticholinergics/Antispasmodics – have limited benefit for treating IBS. In some persons they relieve abdominal pain or discomfort, usually if the symptoms occur soon after eating. Examples include dicyclomine (Bentyl), and hyoscyamine (Levsin). Read ...
El procesamiento informático de los materiales del Atlas Lingüístico de la Península Ibérica de Tomás Navarro Tomás

OpenAIRE

García Mouton, Pilar

2010-01-01

Estas páginas dan noticia de la puesta en marcha de un proyecto intramural del CSIC para elaborar y editar definitivamente, en soporte informático, los materiales del Atlas Lingüístico de la Península Ibérica, que Tomás Navarro Tomás dirigió en la primera mitad del siglo XX.
Diseño y desarrollo del Plan de Igualdad en Bonduelle Ibérica S.A.U

OpenAIRE

HIGINO BLAZQUEZ, ANNABELLE

2015-01-01

[ES] El objeto del proyecto es elaborar un plan de igualdad en Bonduelle Ibérica S.A.U. mediante un diagnóstico de situación, analizar la política estratégica en materia de Igualdad de la empresa y proponer acciones y medidas asociadas a dicha política para la toma de decisiones de la Alta Dirección, así como los indicadores clave de seguimiento definidos para los ejes principales en materia de igualdad. Paralelamente, se presentan los procedimientos de control interno de es...
An experimental investigation on the airside performance of fin-and-tube heat exchangers having slit fins under wet condition

International Nuclear Information System (INIS)

Kim, Nae Hyun; Kim, Tae Hun

2015-01-01

In this study, the heat transfer and friction characteristics of the 5.3 mm O.D. slit-finned heat exchangers under wet condition have been experimentally investigated. Plain-finned heat exchangers having the same 5.3 mm O.D. tubes are also tested for comparison purpose. The effect of fin pitch on j and f factor is negligible. Slit fin samples yield higher j and f factors than plain fin samples. For one row configuration, the average f factor ratio between slit fin sample and plain fin sample is 2.18. The ratio increases to 2.41 for two row configuration, and to 2.65 for three row configuration. As for the j factor, the ratios are approximately the same (1.61, 1.70 and 1.71 for one, two and three row configuration). Both j and f factor increase as the number of tube row decreases. The same trend is observed for the plain fin samples. At high Reynolds numbers, the j/f ratios of the slit fin are approximately the same as those of the plain fin. At low Reynolds numbers, the j/f ratios of the slit fin are smaller than those of plain fin. Data are compared with existing correlations.
Validity, reliability, and factor analysis of Persian version of quality of life questionnaire for irritable bowel syndrome (IBS-QOL-34

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Nasrine Masaeli

2013-01-01

Full Text Available Background: Quality of life (QOL improvement is the main objective of treating patients with irritable bowel syndrome (IBS. This study aimed to assess the validity, reliability, and factor analysis of IBS-QOL-34 questionnaire as a common transcultural instrument for Iranian IBS patients. Materials and Methods: Two hundred and forty patients with IBS (based on gastroenterologists′ diagnosis according to ROM III criteria were referred to Digestive Health Clinic in Psychosomatic Research Center have been selected in this study. Aside with IBS-QOL-34, MOS 36-item short-form health survey (SF-36 and IBS severity index (IBSSI questionnaires were completed by the cases for determination of correlation coefficients; the data were analyzed using descriptive statistics, factor analysis, Cronbach′s alpha, Pearson correlation coefficient by Statistical Package for Social Sciences (SPSS software, version 18. Results: Total reliability of the questionnaire was reported by using Cronbach′s alpha as 0.95, ranging from 0.65 to 0.90. Correlation coefficients of concurrent implementation of IBS-QOL with SF-36 and IBSSI resulted in −0.61 and 0.64, respectively. Exploratory factor analysis using varimax rotation identified eight principle components, which will determine QOL at 67% variance. Conclusion: According to the results, IBS-QOL-34 questionnaire has good psychometric properties in the research community and can be safely used as a valid tool to assess QOL of patients with IBS for healthcare and therapeutic purposes.
Experimental Investigation on Effect of Fin Shape on the Thermal-Hydraulic Performance of Compact Fin-and-Tube Heat Exchangers

Science.gov (United States)

Moorthy, P.; Oumer, A. N.; Ishak, M.

2018-03-01

The aim of this paper is to investigate the effect of fin shapes on the performance of compact finned flat tube heat exchangers. Three types of fin shapes namely plain, wavy, and rectangular grooved fins attached to three by three arrays of flat tube banks were considered. Moreover, the tubes were deployed in in-line and staggered arrangements. In addition to the fin shapes, the air velocity and the tube inclination angles were varied and the thermal-hydraulic performance was analysed. On the other hand, the temperatures at the tube surfaces were kept constant to produce constant heat flux throughout the study. The results showed that as flowrate increases, the heat transfer increases, however, the friction factor decreases. Staggered arrangement produces higher heat transfer and friction factor than inline fin. Moreover, the rectangular fin is the best in terms of high heat transfer however the drawback of high friction factor leads the fin to have the least efficiency of all. On the other hand, plain fin had the least heat transfer performance however the highest efficiency was achieved. Therefore, plain fin should be used when efficiency is prioritized and rectangular fin when high heat transfer is desired.
Integrals for IBS and Beam Cooling

International Nuclear Information System (INIS)

Burov, A.

2005-01-01

Simulation of beam cooling usually requires performing certain integral transformations every time step or so, which is a significant burden on the CPU. Examples are the dispersion integrals (Hilbert transforms) in the stochastic cooling, wake fields and IBS integrals. An original method is suggested for fast and sufficiently accurate computation of the integrals. This method is applied for the dispersion integral. Some methodical aspects of the IBS analysis are discussed
Medications (for IBS)

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Full Text Available ... of a physician. Read more about laxatives. Bulking agents – provided they relieve and don’t worsen symptoms, can ease stool passage. Examples include bran or psyllium. Anticholinergics/Antispasmodics – have limited benefit for treating IBS. In some persons they relieve ...
Los materiales hercínicos de la cordillera ibérica en el contexto del macizo ibérico

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Liñán, E.

1988-12-01

Asturoccidental-Leonesa por la Cordillera Ibérica. Entre estos datos destacan, de una parte, el paralelismo entre los antiformes del Narcea y Paracuellos, surcados por un accidente tectónico que separa a ambos lados sucesiones precámbricas distintas; de otra, la similar disposición de la secuencia estratigráfica entre la región cantábrica y la región ibérica, a uno y otro lado de los antiformes; y por último, la existencia de afloramientos con una estructura de cabalgamientos y pliegues en el área oriental de la Cadena Ibérica que es más semejante a la de la Zona Cantábrica.
Plan de Mercadeo para una “FinTech”.

OpenAIRE

Escalante Lee, Maria Alejandra

2016-01-01

Las empresas deben contar con una misión clara, estableciendo los objetivos de apoyo, diseñando una cartera de negocio sólida y coordinar sus estrategias a futuro, con el fin de cumplir las metas propuestas para entregar e intercambiar ofertas que tienen valor para los consumidores, clientes, socios y la sociedad en general. El presente trabajo de grado tiene como objetivo proponer un plan de mercadeo para la empresa Comyno una FinTech ubicada en Frankfurt am Main, en Alemania. Este tiene ...
Small Tails Tell Tall Tales--Intra-Individual Variation in the Stable Isotope Values of Fish Fin.

Directory of Open Access Journals (Sweden)

Brian Hayden

Full Text Available Fish fin is a widely used, non-lethal sample material in studies using stable isotopes to assess the ecology of fishes. However, fish fin is composed of two distinct tissues (ray and membrane which may have different stable isotope values and are not homogeneously distributed within a fin. As such, estimates of the stable isotope values of a fish may vary according to the section of fin sampled.To assess the magnitude of this variation, we analysed carbon (δ13C, nitrogen (δ15N, hydrogen (δ2H and oxygen (δ18O stable isotopes of caudal fin from juvenile, riverine stages of Atlantic salmon (Salmo salar and brown trout (Salmo trutta. Individual fins were sub-sectioned into tip, mid and base, of which a further subset were divided into ray and membrane.Isotope variation between fin sections, evident in all four elements, was primarily related to differences between ray and membrane. Base sections were13C depleted relative to tip (~1‰ with equivalent variation evident between ray and membrane. A similar trend was evident in δ2H, though the degree of variation was far greater (~10‰. Base and ray sections were 18O enriched (~2‰ relative to tip and membrane, respectively. Ray and membrane sections displayed longitudinal variation in 15N mirroring that of composite fin (~1‰, indicating that variation in15N values was likely related to ontogenetic variation.To account for the effects of intra-fin variability in stable isotope analyses we suggest that researchers sampling fish fin, in increasing priority, 1 also analyse muscle (or liver tissue from a subsample of fish to calibrate their data, or 2 standardize sampling by selecting tissue only from the extreme tip of a fin, or 3 homogenize fins prior to analysis.
FIN5 positively regulates far-red light responses in Arabidopsis thaliana

International Nuclear Information System (INIS)

Cho, D.S.; Hong, S.H.; Nam, H.G.; Soh, M.S.

2003-01-01

We report the characterization of a semi-dominant mutation fin5-1 (far-red insensitive 5-1) of Arabidopsis, which was isolated from genetic screening of phytochrome A (phyA) signaling components. Plants with the fin5-1 mutation exhibited a long hypocotyl phenotype when grown under far-red (FR) light, but not under red light. Physiological analyses implied that FIN5 might be differentially involved in diverse responses that are regulated by phyA under continuous FR light. Anthocyanin accumulation, gravitropic response of hypocotyl growth, and FR light-preconditioned blocking of greening were also impaired in the fin5-1 mutant, whereas photoperiodic floral induction was not, if at all, significantly affected. Moreover, light-regulated expression of the CHS, PORA and PsbS genes was attenuated in fin5-1 mutant plants, while the light-induced expression of CAB was normal. The mutation exhibited semi-dominance regarding control of hypocotyl growth in FR light. We suggest that FIN5 defines a novel branch in the network of phyA signaling in Arabidopsis. (author)
Patient educational media preferences for information about irritable bowel syndrome (IBS).

Science.gov (United States)

Halpert, Albena; Dalton, Christine B; Palsson, Olafur; Morris, Carolyn; Hu, Yuming; Bangdiwala, Shrikant; Hankins, Jane; Norton, Nancy; Drossman, Douglas A

2008-12-01

To identify the educational media preferences of patients with irritable bowel syndrome (IBS). The IBS-Patient Education Questionnaire (PEQ) was administered to a national sample of IBS patients. Frequencies of item endorsements were compared and meaningful clinical differences were used to identify differences among subgroups. 1,242 patients completed the survey, mean age 39.3 years, 85% female, IBS duration 6.9 years, 79% had seen an MD for IBS within 6 months, and 92.6% used the web for medical information. The most desired source of education was "my doctor" (68%), followed by Internet (62%) and brochure (45%). Notably, patients favored an increase in use of media in the future (past vs. future): doctor (43 vs. 68%); Internet (36 vs. 62%); and brochures (26 vs. 45%). IBS patients expect more education than they have received. Understanding IBS patients' learning preferences can be highly valuable in the development or implementation of educational interventions.

Fin shape thermal optimization using Bejan's constuctal theory

CERN Document Server

Lorenzini, Giulio

2011-01-01

The book contains research results obtained by applying Bejan's Constructal Theory to the study and therefore the optimization of fins, focusing on T-shaped and Y-shaped ones. Heat transfer from finned surfaces is an example of combined heat transfer natural or forced convection on the external parts of the fin, and conducting along the fin. Fin's heat exchange is rather complex, because of variation of both temperature along the fin and convective heat transfer coefficient. Furthermore possible presence of more fins invested by the same fluid flow has to be considered.Classical fin theory tri
Evaluation of the 8th AJCC staging system for pathologically versus clinically staged pancreatic adenocarcinoma: A time to revisit a dogma?

Science.gov (United States)

Abdel-Rahman, Omar

2018-02-01

The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for pancreatic exocrine adenocarcinoma has been released. The current study seeks to assess the 7th and 8th editions among patients registered within the surveillance, epidemiology and end results (SEER) database. SEER database (2010-2013) has been accessed through SEER*Stat program and AJCC 8th edition stages were reconstructed utilizing the collaborative stage descriptions. Kaplan-Meier analysis of overall survival and pancreatic cancer-specific survival analyses (according to both 7th and 8th editions and according to whether pathological or clinical staging were conducted) has been performed. Multivariate analysis of factors affecting pancreatic cancer-specific survival was also conducted through a Cox proportional hazard model. A total of 18 948 patients with pancreatic adenocarcinoma were identified in the period from 2010-2013. Pancreatic cancer-specific survival among pathologically staged patients and according to the 8th edition showed significant differences for all pair wise comparisons among different stages (P < 0.0001) except for the comparison between stage IA and stage IB (P = 0.307) and the comparison between stage IB and stage IIA (P = 0.116). Moreover, P value for stage IA vs IIA was 0.014; while pancreatic cancer-specific survival according to the 7th edition among pathologically staged patients showed significant differences for all pair wise comparisons among different stages (P < 0.0001) except for the comparison between IA and IB (P = 0.072), the comparison between stage IIA and stage IIB (P = 0.065), the comparison between stage IIA and stage III (P = 0.059) and the comparison between IIB and III (P = 0.595). Among clinically staged patients (i.e. those who did not undergo initial radical surgery), the prognostic performance of both 7th and 8th stages for both overall survival and pancreatic cancer-specific survival was
Experimental Validation of Elliptical Fin-Opening Behavior

Directory of Open Access Journals (Sweden)

James M. Garner

2003-01-01

Full Text Available An effort to improve the performance of ordnance has led to the consideration of the use of folding elliptical fins for projectile stabilization. A second order differential equation was used to model elliptical fin deployment history and accounts for: deployment with respect to the geometric properties of the fin, the variation in fin aerodynamics during deployment, the initial yaw effect on fin opening, and the variation in deployment speed based on changes in projectile spin. This model supports tests conducted at the Transonic Experimental Facility, Aberdeen Proving Ground examining the opening behavior of these uniquely shaped fins. The fins use the centrifugal force from the projectile spin to deploy. During the deployment, the fin aerodynamic forces vary with angle-of-attack changes to the free stream. Model results indicate that projectile spin dominates the initial opening rates and aerodynamics dominate near the fully open state. The model results are examined to explain the observed behaviors, and suggest improvements for later designs.
Comprehensive performance comparison of airfoil fin PCHEs with NACA 00XX series airfoil

Energy Technology Data Exchange (ETDEWEB)

Chen, Fei, E-mail: chenfei@iet.cn [Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100190 (China); Heating Technology Research and Development Center, Beijing District Heating Group, Beijing 100028 (China); Zhang, Lishen, E-mail: lishenzhang@sina.com [Heating Technology Research and Development Center, Beijing District Heating Group, Beijing 100028 (China); Huai, Xiulan, E-mail: hxl@iet.cn [Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100190 (China); Li, Jufeng, E-mail: lijufeng.net@163.com [Nuclear and Radiation Safety Center, Ministry of Environmental Protection, Beijing 100082 (China); Zhang, Hang, E-mail: zhanghang@iet.cn [Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100190 (China); Liu, Zhigang, E-mail: zgliu9322@163.com [Energy Research Institute of Shandong Academy of Sciences, Jinan, Shandong 250014 (China)

2017-04-15

Highlights: • Pressure drop of NACA 0020 airfoil fin PCHE reduces strikingly in comparison with the zigzag PCHE. • Pressure drop of NACA 00XX airfoil fin PCHE decreases as airfoil thickness increases. • Heat transfer performance of NACA 00XX airfoil fin PCHE increases as airfoil thickness rises. • Comprehensive performance of NACA 00XX airfoil fin PCHE degrades as airfoil thickness increases. - Abstract: Printed circuit heat exchanger (PCHE) can be used in supercritical carbon dioxide (S-CO{sub 2}) Brayton cycle. The present study compares NACA 0020 airfoil fin PCHE with conventional zigzag PCHE by numerical analysis. Pressure drop of the former has a striking reduction while maintaining excellent heat transfer performance. Comparison on four NACA 00XX series airfoil fin PCHEs is performed to investigate the influence of airfoil profile on flow and heat transfer performance. With a fixed vertical pitch, heat transfer performance of NACA series airfoil fin PCHE increases as airfoil thickness increases. However, comprehensive performance, in which both flow and heat transfer are taken into account, degrades with increasing airfoil thickness. Among four NACA airfoil fin PCHEs presented in this paper, NACA 0010 airfoil fin PCHE demonstrates the best comprehensive performance.
Comprehensive performance comparison of airfoil fin PCHEs with NACA 00XX series airfoil

International Nuclear Information System (INIS)

Chen, Fei; Zhang, Lishen; Huai, Xiulan; Li, Jufeng; Zhang, Hang; Liu, Zhigang

2017-01-01

Highlights: • Pressure drop of NACA 0020 airfoil fin PCHE reduces strikingly in comparison with the zigzag PCHE. • Pressure drop of NACA 00XX airfoil fin PCHE decreases as airfoil thickness increases. • Heat transfer performance of NACA 00XX airfoil fin PCHE increases as airfoil thickness rises. • Comprehensive performance of NACA 00XX airfoil fin PCHE degrades as airfoil thickness increases. - Abstract: Printed circuit heat exchanger (PCHE) can be used in supercritical carbon dioxide (S-CO_2) Brayton cycle. The present study compares NACA 0020 airfoil fin PCHE with conventional zigzag PCHE by numerical analysis. Pressure drop of the former has a striking reduction while maintaining excellent heat transfer performance. Comparison on four NACA 00XX series airfoil fin PCHEs is performed to investigate the influence of airfoil profile on flow and heat transfer performance. With a fixed vertical pitch, heat transfer performance of NACA series airfoil fin PCHE increases as airfoil thickness increases. However, comprehensive performance, in which both flow and heat transfer are taken into account, degrades with increasing airfoil thickness. Among four NACA airfoil fin PCHEs presented in this paper, NACA 0010 airfoil fin PCHE demonstrates the best comprehensive performance.
Effect of Using Extra Fins on the Pin Fin Classic Geometry for Enhancement Heat Sink Performance using EGM Method

Directory of Open Access Journals (Sweden)

Kadhum Audaa Jehhef

2018-04-01

Full Text Available In the present study, the effect of new cross-section fin geometries on overall thermal/fluid performance had been investigated. The cross-section included the base original geometry of (triangular, square, circular, and elliptical pin fins by adding exterior extra fins along the sides of the origin fins. The present extra fins include rectangular extra fin of 2 mm (height and 4 mm (width and triangular extra fin of 2 mm (base 4 mm (height. The use of entropy generation minimization method (EGM allows the combined effect of thermal resistance and pressure drop to be assessed through the simultaneous interaction with the heat sink. A general dimensionless expression for the entropy generation rate is obtained by considering a control volume around the pin fin including a base plate and applying the conservations equations of mass and energy with the entropy balance. The dimensionless numbers used includes the aspect ratio (ε, Reynolds number (Re, Nusselt number (Nu, and the drag coefficients (CD. Fourteen different cross-section fin geometries are examined for the heat transfer, fluid friction, and the minimum entropy generation rate. The results showed that the Nusselt number increases with increasing the Reynolds number for all employed models. The ellipse models (ET and ER-models give the highest value in the Nusselt number as compared with the classical pin fins. The fin of the square geometry with four rectangular extra fins (SR-models gives an agreement in Nusselt number as compared with the previous study.
Atom-probe for FinFET dopant characterization

Energy Technology Data Exchange (ETDEWEB)

Kambham, A.K., E-mail: kambham@imec.be [K.U.Leuven, Instituut voor Kern-en Stralings fysika, Celestijnenlaan 200D, B-3001, Leuven (Belgium); IMEC, Kapeldreef 75, B-3001 Leuven (Belgium); Mody, J.; Gilbert, M.; Koelling, S.; Vandervorst, W. [K.U.Leuven, Instituut voor Kern-en Stralings fysika, Celestijnenlaan 200D, B-3001, Leuven (Belgium); IMEC, Kapeldreef 75, B-3001 Leuven (Belgium)

2011-05-15

With the continuous shrinking of transistors and advent of new transistor architectures to keep in pace with Moore's law and ITRS goals, there is a rising interest in multigate 3D-devices like FinFETs where the channel is surrounded by gates on multiple surfaces. The performance of these devices depends on the dimensions and the spatial distribution of dopants in source/drain regions of the device. As a result there is a need for new metrology approach/technique to characterize quantitatively the dopant distribution in these devices with nanometer precision in 3D. In recent years, atom probe tomography (APT) has shown its ability to analyze semiconductor and thin insulator materials effectively with sub-nm resolution in 3D. In this paper we will discuss the methodology used to study FinFET-based structures using APT. Whereas challenges and solutions for sample preparation linked to the limited fin dimensions already have been reported before, we report here an approach to prepare fin structures for APT, which based on their processing history (trenches filled with Si) are in principle invisible in FIB and SEM. Hence alternative solutions in locating and positioning them on the APT-tip are presented. We also report on the use of the atom probe results on FinFETs to understand the role of different dopant implantation angles (10{sup o} and 45{sup o}) when attempting conformal doping of FinFETs and provide a quantitative comparison with alternative approaches such as 1D secondary ion mass spectrometry (SIMS) and theoretical model values. -- Research highlights: {yields} This paper provides the information on how to characterize the FinFET devices using atom probe tomography (APT). {yields} Importance of this work is to assess the performance of these devices at different processing conditions by extracting the compositional profiles. {yields} The performance of these devices depends on the dimensions and the spatial distribution of dopants in source/drain regions
Experimental studies of Savonius wind turbines with variations sizes and fin numbers towards performance

Science.gov (United States)

Utomo, Ilham Satrio; Tjahjana, Dominicus Danardono Dwi Prija; Hadi, Syamsul

2018-02-01

The use of renewable energy in Indonesia is still low. Especially the use of wind energy. Wind turbine Savonius is one turbine that can work with low wind speed. However, Savonius wind turbines still have low efficiency. Therefore it is necessary to modify. Modifications by using the fin are expected to increase the positive drag force by creating a flow that can enter the overlap ratio of the gap. This research was conducted using experimental approach scheme. Parameters generated from the experiment include: power generator, power coefficient, torque coefficient. The experimental data will be collected by variation of fin area, horizontal finning, at wind speed 3 m/s - 4,85 m/s. Experimental results show that with the addition of fin can improve the performance of wind turbine Savonius 11%, and by using the diameter of 115 mm fin is able to provide maximum performance in wind turbine Savonius.
从FinTech到RegTech

Institute of Scientific and Technical Information of China (English)

孙国峰[1,2

2017-01-01

本文分析FinTech（金融科技）监管的必要性，并介绍了FinTech监管的国际经验，在此基础上提出了我国可以探索将人工智能应用于金融监管，即以RegTech（监管科技）应对FinTech的建议。
Thermal transport in oblique finned microminichannels

CERN Document Server

Fan, Yan; Singh, Pawan Kumar; Lee, Yong Jiun

2015-01-01

The main aim of this book is to introduce and give an overview of a novel, easy, and highly effective heat transfer augmentation technique for single-phase micro/minichannel heat sink. The specific objectives of the volume are to: Introduce a novel planar oblique fin microchannel and cylindrical oblique fin minichannel heat sink design using passive heat transfer enhancement techniques Investigate the thermal transport in both planar and cylindrical oblique fin structures through numerical simulation and systematic experimental studies. Evaluate the feasibility of employing the proposed solution in cooling non-uniform heat fluxes and hotspot suppression Conduct the similarity analysis and parametric study to obtain empirical correlations to evaluate the total heat transfer rate of the oblique fin heat sink Investigate the flow mechanism and optimize the dimensions of cylindrical oblique fin heat sink Investigate the influence of edge effect on flow and temperature uniformity in these oblique fin chan...
Numerical analysis of steady state and transient analysis of high temperature ceramic plate-fin heat exchanger

International Nuclear Information System (INIS)

Nagarajan, Vijaisri; Chen, Yitung; Wang, Qiuwang; Ma, Ting

2014-01-01

Highlights: • Rip saw fin design is considered to be the best because it has thin fins and has higher heat transfer coefficient. • Minimum principal stress and maximum safety factor are obtained for the inverted bolt fin design. • Maximum principal stress and minimum safety factor are obtained for triangular fin design. • Thermal stress has significant impact than mechanical stress. • High principal stress is found at the startup and shutdown stage. - Abstract: In this study three-dimensional model of ceramic plate-fin high temperature heat exchanger with different fin designs and arrangements is analyzed numerically using ANSYS FLUENT and ANSYS structural module. The ability of ceramics to withstand high temperature and corrosion makes silicon carbide (SiC) suitable candidate material to be used in high temperature heat exchanger. The operating temperature of heat exchanger is 950 °C and the operating pressure is 1.5 MPa. The working fluids are helium, sulfur trioxide, sulfur dioxide, oxygen and the water vapor. Fluid flow and heat transfer analysis are carried out for steady and transient state in FLUENT. The obtained thermal and pressure load for the steady and transient state from ANSYS FLUENT are imported to ANSYS structural module to obtain the principal stress and the factor of safety. Different arrangements of rectangular fins, triangular fins, inverted bolt fins and ripsaw fins are studied. From the results it is found that the minimum stress and the maximum safety factor are obtained for inverted bolt fins. The triangular fins have the maximum principal stress and minimum factor of safety. However, the fluid flow and heat transfer analysis show inverted bolt fins and triangular fins produce higher pressure drop and friction factor. The steady state maximum principal stress is 10.08 MPa, 9.90 MPa and 11.43 MPa for straight, staggered and top and bottom ripsaw fin arrangement. The corresponding safety factors are 21.80, 21.95 and 19
Heavy Metal Exposure in Predicting Peripheral Neuropathy in Patients With Stage I-III Breast Cancer Undergoing Chemotherapy

Science.gov (United States)

2017-06-14

Male Breast Cancer; Neurotoxicity; Peripheral Neuropathy; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Minocycline Hydrochloride in Reducing Chemotherapy Induced Depression and Anxiety in Patients With Stage I-III Breast Cancer

Science.gov (United States)

2017-08-07

Anxiety Disorder; Depression; Recurrent Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
UOP FIN 571 Final Exam Guide New

OpenAIRE

ADMIN

2018-01-01

UOP FIN 571 Final Exam Guide New Check this A+ tutorial guideline at http://www.fin571assignment.com/fin-571-uop/fin-571-final-exam-guide -latest For more classes visit http://www.fin571assignment.com Question 1 The underlying assumption of the dividend growth model is that a stock is worth: A. An amount computed as the next annual dividend divided by the required rate of return. B. An amount computed as the next annual dividend divided by the ma...
Short Course Vaginal Cuff Brachytherapy in Treating Patients With Stage I-II Endometrial Cancer

Science.gov (United States)

2018-04-17

Endometrial Clear Cell Adenocarcinoma; Endometrial Endometrioid Adenocarcinoma; Endometrial Serous Adenocarcinoma; Stage I Uterine Corpus Cancer; Stage IA Uterine Corpus Cancer; Stage IB Uterine Corpus Cancer; Stage II Uterine Corpus Cancer; Uterine Corpus Carcinosarcoma; Uterine Corpus Sarcoma
Ontogenetic scaling of caudal fin shape in Squalus acanthias (Chondrichthyes, Elasmobranchii): a geometric morphometric analysis with implications for caudal fin functional morphology.

Science.gov (United States)

Reiss, Katie L; Bonnan, Matthew F

2010-07-01

The shark heterocercal caudal fin and its contribution to locomotion are of interest to biologists and paleontologists. Current hydrodynamic data show that the stiff dorsal lobe leads the ventral lobe, both lobes of the tail are synchronized during propulsion, and tail shape reflects its overall locomotor function. Given the difficulties surrounding the analysis of shark caudal fins in vivo, little is known about changes in tail shape related to ontogeny and sex in sharks. A quantifiable analysis of caudal fin shape may provide an acceptable proxy for inferring gross functional morphology where direct testing is difficult or impossible. We examined ontogenetic and sex-related shape changes in the caudal fins of 115 Squalus acanthias museum specimens, to test the hypothesis that significant shape changes in the caudal fin shape occur with increasing size and between the sexes. Using linear and geometric morphometrics, we examined caudal shape changes within the context of current hydrodynamic models. We found no statistically significant linear or shape difference between sexes, and near-isometric scaling trends for caudal dimensions. These results suggest that lift and thrust increase linearly with size and caudal span. Thin-plate splines results showed a significant allometric shape change associated with size and caudal span: the dorsal lobe elongates and narrows, whereas the ventral lobe broadens and expands ventrally. Our data suggest a combination of caudal fin morphology with other body morphology aspects, would refine, and better elucidate the hydrodynamic factors (if any) that underlie the significant shape changes we report here for S. acanthias.
Diverse regulation of retinal pigment epithelium phagocytosis of photoreceptor outer segments by calcium-independent phospholipase A₂, group VIA and secretory phospholipase A₂, group IB

DEFF Research Database (Denmark)

Zhan, Chen; Wang, Jinmei; Kolko, Miriam

2012-01-01

PURPOSE: To investigate the roles of the phospholipases A(2) (PLA(2)) subtypes, iPLA(2)-VIA and sPLA(2)-IB in retinal pigment epithelium (RPE) phagocytosis of photoreceptor outer segments (POS) and to explore a possible interaction between sPLA(2)-IB and iPLA(2)-VIA in the RPE. METHODS: To explore...... the role of iPLA(2)-VIA in RPE phagocytosis of POS, experiments with iPLA(2)-VIA vector transfection, iPLA(2)-VIA(-/-) knockout (KO) mice, and iPLA(2)-VIA inhibition by bromoenol lactone (BEL) were done. Exogenous addition of sPLA(2)-IB was used to investigate the role of sPLA(2)-IB in RPE phagocytosis....... A Luciferase Reporter Vector containing the iPLA(2)-VIA promoter was used to study the effects of sPLA(2)-IB on the iPLA(2)-VIA promoter. RESULTS: ARPE-19 and primary mouse RPE cells transfected with iPLA(2)-VIA showed increased phagocytosis. Phagocytosis was reduced in primary mouse RPE inhibited with BEL...
Postoperative high dose rate vaginal apex brachytherapy in stage I endometrial adenocarcinoma

International Nuclear Information System (INIS)

Turner, B.; Knisely, J.; Kacinski, B.; Roberts, K.; Peschel, R.; Gumbs, A.; Rutherford, T.; Edraki, B.; Schwartz, P.; Chambers, J.; Kohorn, E.; Wilson, L.

1996-01-01

Introduction: Patients with stage I endometrial adenocarcinoma have traditionally been treated with TAH/BSO and radiation. The reported incidence of local recurrence in surgically treated patients with Figo stage IA or IB endometrial adenocarcinoma is 4-10% at 2 years. Combined surgery and radiation has resulted in a reduction of recurrence to 2-6%. We report the presentation, local and distant control, salvage rate, survival and complications for patients undergoing high dose rate (HDR) vaginal apex brachytherapy following surgery. Methods: Between 1985 and 1994 a total of 302 patients with Figo stage I endometrial carcinoma were treated with HDR Ir-192 vaginal apex brachytherapy to a total dose of 21 Gy in 3 fractions at 0.5 cm from the vaginal mucosa. The pathologic stage by treatment group was IA: 31%, IB: 68%, and IC: 1%. The histologic grade of the patient's tumors was grade 1: 69%, 2: 27%, and 3: 4%. The median time from surgery to radiation was 33 days (range 14-66 days). The median follow-up for 300 patients with stage IA (91 patients), IB (205 patients), and IC (4 patients) was respectively 36, 34 and 40 months (2 patients lost to follow-up prior to 6 months). Results: Patients presented with vaginal bleeding (94%) or abnormal pap smear (6%) at a median age for stage IA and IB, of 55 and 64 years, respectively. The crude overall survival of the patient population at 2 years is 95%. Median overall time to failure is 19.5 months (range 10-36 months). The overall failure rate was 2.7% (8 patients), local failure only 1.0% (38% of failed group), distant failure only 0.3% (12% of failed group) and combined local/distant failure 1.3% (50% of failed group). The local failure rate for pathologic stage IA patients was 1.0% and no distant disease was observed. The local failure rate for pathologic stage IB patients was 3.4% 7/205 and distant failure was 2.4% 5/205. The majority of patients with recurrence had grade 2 histologic changes 5/8. The overall salvage rate
Quality of life in patients with Irritable Bowel Syndrome (IBS), assessed using the IBS-Quality of Life (IBS-QOL) measure after 4 and 8 weeks of treatment with mebeverine hydrochloride or pinaverium bromide: results of an international prospective observational cohort study in Poland, Egypt, Mexico and China.

Science.gov (United States)

Hou, Xiaohua; Chen, Shengliang; Zhang, Yali; Sha, Weihong; Yu, Xiaofeng; Elsawah, Hesham; Afifi, Afifi Fahmy; El-Khayat, Hisham Raafat; Nouh, Alaa; Hassan, Mohamed Fathalla; Fatah, Ayman Abdel; Rucker Joerg, Isabel; Sánchez Núñez, Juan Manuel; Osthoff Rueda, Rodolfo; Jurkowska, Grazyna; Walczak, Michal; Malecka-Panas, Ewa; Linke, Krzysztof; Hartleb, Marek; Janssen-van Solingen, Gwendolyn

2014-11-01

Irritable Bowel Syndrome (IBS) has a substantial impact on health-related quality of life (HR-QoL) but high-quality data pre- and post-treatment using the IBS-Quality of Life (IBS-QOL) measure are limited. The objective of this study was to evaluate the changes from baseline of the IBS-QOL scores, symptom scores and health economic data in IBS patients, after 4 and 8 weeks of treatment with mebeverine hydrochloride or pinaverium bromide. This was a prospective observational cohort study in patients with IBS, diagnosed using the Rome III criteria in four countries (Poland, Egypt, Mexico and China). A total of 607 patients were enrolled. At baseline, the IBS-QOL total scores were 52.0 in Poland, 48.9 in Egypt, 51.9 in Mexico, 76.4 in China and 56.4 overall. Increases in IBS-QOL total score were statistically significant at Weeks 4 and 8 overall and in each country (overall: 11.8 at Week 4, 24.3 at Week 8; p < 0.001). Improvements were shown in all IBS-QOL subscales and scores. Symptoms and health economic outcomes were improved. Furthermore, the favourable safety profile of these treatments was confirmed in this study. This study demonstrated that IBS patients have a substantially reduced HR-QoL and that treatment with mebeverine hydrochloride or pinaverium bromide improved HR-QoL.
Randomised controlled trial of mesalazine in IBS.

Science.gov (United States)

Barbara, Giovanni; Cremon, Cesare; Annese, Vito; Basilisco, Guido; Bazzoli, Franco; Bellini, Massimo; Benedetti, Antonio; Benini, Luigi; Bossa, Fabrizio; Buldrini, Paola; Cicala, Michele; Cuomo, Rosario; Germanà, Bastianello; Molteni, Paola; Neri, Matteo; Rodi, Marcello; Saggioro, Alfredo; Scribano, Maria Lia; Vecchi, Maurizio; Zoli, Giorgio; Corinaldesi, Roberto; Stanghellini, Vincenzo

2016-01-01

Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS. We conducted a phase 3, multicentre, tertiary setting, randomised, double-blind, placebo-controlled trial in patients with Rome III confirmed IBS. Patients were randomly assigned to either mesalazine, 800 mg, or placebo, three times daily for 12 weeks, and were followed for additional 12 weeks. The primary efficacy endpoint was satisfactory relief of abdominal pain/discomfort for at least half of the weeks of the treatment period. The key secondary endpoint was satisfactory relief of overall IBS symptoms. Supportive analyses were also performed classifying as responders patients with a percentage of affirmative answers of at least 75% or >75% of time. A total of 185 patients with IBS were enrolled from 21 centres. For the primary endpoint, the responder patients were 68.6% in the mesalazine group versus 67.4% in the placebo group (p=0.870; 95% CI -12.8 to 15.1). In explorative analyses, with the 75% rule or >75% rule, the percentage of responders was greater in the mesalazine group with a difference over placebo of 11.6% (p=0.115; 95% CI -2.7% to 26.0%) and 5.9% (p=0.404; 95% CI -7.8% to 19.4%), respectively, although these differences were not significant. For the key secondary endpoint, overall symptoms improved in the mesalazine group and reached a significant difference of 15.1% versus placebo (p=0.032; 95% CI 1.5% to 28.7%) with the >75% rule. Mesalazine treatment was not superior than placebo on the study primary endpoint. However, a subgroup of patients with IBS showed a sustained therapy response and benefits from a mesalazine therapy. ClincialTrials.gov number, NCT00626288. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Numerical studies on heat transfer and pressure drop characteristics of flat finned tube bundles with various fin materials

Science.gov (United States)

Peng, Y.; Zhang, S. J.; Shen, F.; Wang, X. B.; Yang, X. R.; Yang, L. J.

2017-11-01

The air-cooled heat exchanger plays an important role in the field of industry like for example in thermal power plants. On the other hand, it can be used to remove core decay heat out of containment passively in case of a severe accident circumstance. Thus, research on the performance of fins in air-cooled heat exchangers can benefit the optimal design and operation of cooling systems in nuclear power plants. In this study, a CFD (Computational Fluid Dynamic) method is implemented to investigate the effects of inlet velocity, fin spacing and tube pitch on the flow and the heat transfer characteristics of flat fins constructed of various materials (316L stainless steel, copper-nickel alloy and aluminium). A three dimensional geometric model of flat finned tube bundles with fixed longitudinal tube pitch and transverse tube pitch is established. Results for the variation of the average convective heat transfer coefficient with respect to cooling air inlet velocity, fin spacing, tube pitch and fin material are obtained, as well as for the pressure drop of the cooling air passing through finned tube. It is shown that the increase of cooling air inlet velocity results in enhanced average convective heat transfer coefficient and decreasing pressure drop. Both fin spacing and tube pitch engender positive effects on pressure drop and have negative effects on heat transfer characteristics. Concerning the fin material, the heat transfer performance of copper-nickel alloy is superior to 316L stainless steel and inferior to aluminium.
′Belonging without Belonging′: Colm Tóibín′s Dialogue with the Past

DEFF Research Database (Denmark)

Bøss, Michael

2005-01-01

It is argued that Tóibín is not the typical 'revisionist' intellectual that some have made him into, but a humanist and a sort of in-between, making a virtue of his own ambivalences towards notions of tradition, community and nationhood. The essay makes an analysis of these ambivalences with refe...
The sweet potato IbMYB1 gene as a potential visible marker for sweet potato intragenic vector system.

Science.gov (United States)

Kim, Cha Young; Ahn, Young Ock; Kim, Sun Ha; Kim, Yun-Hee; Lee, Haeng-Soon; Catanach, Andrew S; Jacobs, Jeanne M E; Conner, Anthony J; Kwak, Sang-Soo

2010-07-01

MYB transcription factors play important roles in transcriptional regulation of many secondary metabolites including anthocyanins. We cloned the R2R3-MYB type IbMYB1 complementary DNAs from the purple-fleshed sweet potato (Ipomoea batatas L. cv Sinzami) and investigated the expression patterns of IbMYB1 gene with IbMYB1a and IbMYB1b splice variants in leaf and root tissues of various sweet potato cultivars by reverse transcription-polymerase chain reaction. The transcripts of IbMYB1 were predominantly expressed in the purple-fleshed storage roots and they were also detectable in the leaf tissues accumulating anthocyanin pigments. In addition, transcript levels of IbMYB1 gene were up-regulated by treatment with methyl jasmonate or salicylic acid in leaf and root tissues of cv. White Star. To set up the intragenic vector system in sweet potato, we first evaluated the utilization of the IbMYB1 gene as a visible selectable marker. The IbMYB1a was transiently expressed in tobacco leaves under the control of a constitutive cauliflower mosaic virus 35S promoter, a root-specific and sucrose-inducible sporamin promoter, and an oxidative stress-inducible sweet potato anionic peroxidase2 promoter. We also showed that overexpression of IbMYB1a induced massive anthocyanin pigmentation in tobacco leaves and up-regulated the transcript levels of the structural genes in anthocyanin biosynthetic pathway. Furthermore, high-performance liquid chromatography analysis revealed that the expression of IbMYB1a led to production of cyanidin as a major core molecule of anthocyanidins in tobacco leaves. These results suggest that the IbMYB1 gene can be applicable to a visible marker for sweet potato transformation with intragenic vectors, as well as the production of anthocyanin as important nutritive value in other plant species.
Pseudohypoparathyroidism type Ib associated with novel duplications in the GNAS locus.

Directory of Open Access Journals (Sweden)

Gustavo Perez-Nanclares

Full Text Available Pseudohypoparathyroidism type 1b (PHP-Ib is characterized by renal resistance to PTH (and, sometimes, a mild resistance to TSH and absence of any features of Albright's hereditary osteodystrophy. Patients with PHP-Ib suffer of defects in the methylation pattern of the complex GNAS locus. PHP-Ib can be either sporadic or inherited in an autosomal dominant pattern. Whereas familial PHP-Ib is well characterized at the molecular level, the genetic cause of sporadic PHP-Ib cases remains elusive, although some molecular mechanisms have been associated with this subtype.The aim of the study was to investigate the molecular and imprinting defects in the GNAS locus in two unrelated patients with PHP-Ib.We have analyzed the GNAS locus by direct sequencing, Methylation-Specific Multiplex Ligation-dependent Probe Amplification, microsatellites, Quantitative Multiplex PCR of Short Fluorescent fragments and array-Comparative Genomic Hybridization studies in order to characterize two unrelated families with clinical features of PHP-Ib.We identified two duplications in the GNAS region in two patients with PHP-Ib: one of them, comprising ∼ 320 kb, occurred 'de novo' in the patient, whereas the other one, of ∼ 179 kb in length, was inherited from the maternal allele. In both cases, no other known genetic cause was observed.In this article, we describe the to-our-knowledge biggest duplications reported so far in the GNAS region. Both are associated to PHP-Ib, one of them occurring 'de novo' and the other one being maternally inherited.
El asentamiento orientalizante e ibérico antiguo de "La Rábita", Guardamar del Segura (Alicante. Avance de las excavaciones 1996-1998

Directory of Open Access Journals (Sweden)

Azuar, Rafael

1998-12-01

Full Text Available [es] Al sur de la desembocadura del río Segura, la excavación de La Rábita califal ha revelado la existencia, en el mismo lugar, de un establecimiento de época Orientalizante/Protoibérica e Ibérica Antigua. El hábitat, cuya historia empieza probablemente a finales del siglo VIII o en tomo al 700 a.C., en un momento que se puede fijar hacia el 600 a.C., fue rodeado de una potente muralla que incluye una superficie de 1,5 Ha. El asentamiento ha sido un lugar de intercambios intensos con el mundo orientalizante y fenicio-occidental. [fr] L´établissement orientalisant et ibérique ancien de "La Rábita", Guardamar del Segura (Alicante, Espagne. Campagnes de fouilles, 1996-1998. Au sud de l´embouchure du Segura, la fouille de La Rábita califale a révélé l´existence, au même emplacement, d'un établissement d'époque Orientalisante/Protoibérique et Ibérique Ancienne. L'habitat dont l'histoire commence probablement à la fin du VIIIe siècle ou aux environ de 700 avant J.-C.a été, à un moment que l´on peut situer autour de 600, entouré d'une puissante enceinte; il est alors vaste de 1,5 hectares. L'établissement a été un lieu d'échanges actifs avec le monde orientalisant et phénicien d'Occident.
Data Management Guide: Integrated Baseline System (IBS). Version 2.1

Energy Technology Data Exchange (ETDEWEB)

Bower, J.C. [Bower Software Services, Kennewick, Washington (United States); Burford, M.J.; Downing, T.R.; Moise, M.C.; Williams, J.R. [Pacific Northwest Lab., Richland, WA (United States)

1995-01-01

The Integrated Baseline System (IBS) is an emergency management planning and analysis tool that is being developed under the direction of the US Army Nuclear and Chemical Agency (USANCA). The IBS Data Management Guide provides the background, as well as the operations and procedures needed to generate and maintain a site-specific map database. Data and system managers use this guide to manage the data files and database that support the administrative, user-environment, database management, and operational capabilities of the IBS. This document provides a description of the data files and structures necessary for running the IBS software and using the site map database.
Integrated Baseline System (IBS) Version 1.03: Utilities guide

Energy Technology Data Exchange (ETDEWEB)

Burford, M.J.; Downing, T.R.; Pottier, M.C.; Schrank, E.E.; Williams, J.R.

1993-01-01

The Integrated Baseline System (IBS) is an emergency management planning and analysis tool that was developed under the direction of the Federal Emergency Management Agency (FEMA). This Utilities Guide explains how to operate utility programs that are supplied as a part of the IBS. These utility programs are chiefly for managing and manipulating various kinds of IBS data and system administration files. Many of the utilities are for creating, editing, converting, or displaying map data and other data that are related to geographic location.
Integrated Baseline System (IBS) Version 2.0: Utilities Guide

Energy Technology Data Exchange (ETDEWEB)

Burford, M.J.; Downing, T.R.; Williams, J.R. [Pacific Northwest Lab., Richland, WA (United States); Bower, J.C. [Bower Software Services, Kennewick, WA (United States)

1994-03-01

The Integrated Baseline System (IBS) is an emergency management planning and analysis tool being developed under the direction of the US Army Nuclear and Chemical Agency. This Utilities Guide explains how you can use the IBS utility programs to manage and manipulate various kinds of IBS data. These programs include utilities for creating, editing, and displaying maps and other data that are referenced to geographic location. The intended audience for this document are chiefly data managers but also system managers and some emergency management planners and analysts.
Performance ‘S’ Type Savonius Wind Turbine with Variation of Fin Addition on Blade

Science.gov (United States)

Pamungkas, S. F.; Wijayanto, D. S.; Saputro, H.; Widiastuti, I.

2018-01-01

Wind power has been receiving attention as the new energy resource in addressing the ecological problems of burning fossil fuels. Savonius wind rotor is a vertical axis wind turbines (VAWT) which has relatively simple structure and low operating speed. These characteristics make it suitable for areas with low average wind speed as in Indonesia. To identify the performance of Savonius rotor in generating electrical energy, this research experimentally studied the effect of fin addition for the ‘S’ shape of Savonius VAWT. The fin is added to fill the space in the blade in directing the wind flow. This rotor has two turbine blades, a rotor diameter of 1.1 m and rotor height of 1.4 m, used pulley transmission system with 1:4.2 multiplication ratio, and used a generator type PMG 200 W. The research was conducted during dry season by measuring the wind speed in the afternoon. The average wind speed in the area is 2.3 m/s with the maximum of 4.5 m/s. It was found that additional fin significantly increase the ability of Savonius rotor VAWT to generate electrical energy shown by increasing of electrical power. The highest power generated is 13.40 Watt at a wind speed of 4.5 m/s by adding 1 (one) fin in the blade. It increased by 22.71% from the rotor blade with no additional fin. However, increasing number of fins in the blade was not linearly increase the electrical power generated. The wind rotor blade with 4 additional fins is indicated has the lowest performance, generating only 10.80 Watt electrical power, accounted lower than the one generated by no fin-rotor blade. By knowing the effect of the rotor shape, the rotor dimension, the addition of fin, transmission, and generator used, it is possible to determine alternative geometry design in increasing the electrical power generated by Savonius wind turbine.
FINCRUSH : a computer program for impact analysis of radioactive material transport cask with fins

Energy Technology Data Exchange (ETDEWEB)

Ikushima, Takeshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1997-05-01

In drop impact analyses for radioactive material transport cask with cooling fins, relationship between fin plastic deformation and fin energy absorption is used. This relationship was obtained by ORNL experiments and MONSER Co. in Canada. Based on ORNL experiments, a computer program FINCRUSH has been developed for rapid safety analysis of cask drop impact to obtain the maximum impact acceleration and the maximum fin deformation. Main features of FINCRUSH are as follows: (1) annulus fins on a cylindrical shell and plate fins on a disk can be treated, (2) it is capable of graphical representations for calculation results and fin absorption energy data and (3) not only main frame computer but also work stations (OS UNIX) and personal computer (OS Windows) are available for use of the FINCRUSH. In the paper, brief illustration of calculation method of FINCRUSH is presented. The second section presents comparisons between FINCRUSH and experimental results. The third section provides a use`s guide for FINCRUSH. (author)
Fast breeder cladding tubes provided with helical fins

International Nuclear Information System (INIS)

Baumgaertner, E.; Hoffmann, H.; Miller, H.; Jacobi, O.; Bojarski, E.; Freund, D.; Reiser, H.

1977-04-01

Development of fast breeder tubes with helical fins started around 1966. The development was initiated mainly by the search for a more favorable alternative to the conventional spacers such as grids and spiral wires. First of all the possibility was investigated of fabricating them on an industrial scale. The first thermohydraulic and fluiddynamic tests were made in parallel by AEG, GfK and Interatom. Besides the possibility of industrial fabrication the problems of non-destructive testing for geometry and material defects had to be treated with priority. In this report the different stages of development are shown and, finally, two rather large projects are described. These projects are the study ready for the licensing procedure concerning the irradiation of finned tube oxide fuel elements in KNK II and the already completed 19-rod fuel element bundle irradiation experiment Mol 7D of GfK performed in the 500 kW sodium loop of the Belgian BR2 reactor. In this BR2 experiment the maximum target burnup of 85,000 MWd/t of oxide was attained without trouble. (orig.) [de
Colm Tóibín and Post-Nationalist Ireland: Redefining Family Through Alterity

Directory of Open Access Journals (Sweden)

José Carregal-Romero

2012-03-01

Full Text Available In nationalist Ireland, definitions of family have traditionally followed a hetero-normative and sexist pattern whereby husbands and wives fulfilled deeply unequal roles. Moreover, the notion of family has been too often idealized as a site of peace and unconditional love, its members being united by unbreakable bonds of mutual affection. In Colm Tóibín’s fiction, “traditional” families tend to be dysfunctional and the relations between their members become strained because of emotional distance, regrets and distrust. However, Tóibín’s protagonists do find their sense of home and domesticity outside the traditional parameters of family. In this regard, this paper intends to analyze the manner in which Tóibín de-stabilizes canonical definitions through his revisionist agenda and his inscription of alternative forms of family. In order to shed light on these points, I shall refer to his novels The South (1990, The Heather Blazing (1992, The Blackwater Lightship (1999 and his short stories “A Long Winter” (Mothers and Sons, 2006, “Two Women” and “The Street” (The Empty Family, 2010.
Protein kinase activity associated with the corticosteroid binder IB

International Nuclear Information System (INIS)

Vujicic, M.; Djordjevic-Markovic, R.; Radic, O.; Krstic, M.; Kanazir, D.

1997-01-01

The physiological effects elicited by glucocorticoids are mediated via glucocorticoid receptors (GR). Analysis of specific glucocorticoid binding to radioactively labelled [ 3 H] triamcinolone acetonide in rat liver cytosol and analysis by ion exchange chromatography have revealed the presence of two distinct molecular species. The major form, designated as binder II appears to correspond to the well characterized glucocorticoid receptor by virtue of its size, charge, steroid binding characteristics and ability to bind to DNA.The second form, designated as corticosteroid binder IB, is a minor binding component in the liver. The binder IB differs from the binder II receptor by virtue of its lower molecular weight and its elution in the pre gradient of DEAE-Sephadex A-50 column which retains the un activated binder II receptor complexes. We examined the kinase activity of partially purified corticosteroid binder IB. Using (γ 3 2 P) ATP we detected kinase activity associated with the IB fraction from the rat liver. This kinase phosphorylate mixed histones and and dose not phosphorylate IB protein in vitro. The kinase activity is completely inhibited by the addition of Mg 2 + ions and is partially inhibited by the addition of Ca 2 +ions. (author)
Differentiation of chondrocytes and scleroblasts during dorsal fin skeletogenesis in flounder larvae.

Science.gov (United States)

Suzuki, Tohru; Haga, Yutaka; Takeuchi, Toshio; Uji, Susumu; Hashimoto, Hisashi; Kurokawa, Tadahide

2003-01-01

In teleosts, the embryonic fin fold consists of a peridermis, an underlying epidermis and a small number of mesenchymal cells. Beginning from such a simple structure, the fin skeletons, including the proximal and distal radials and lepidotrichia (finrays), develop in the dorsal fin fold at the larval stage. Their process of skeletogenesis and embryonic origin are unclear. Using flounder larvae, we report the differentiation process for chondrocytes and scleroblasts prior to fin skeletogenesis and the effects of retinoic acid (RA) on it. In early larvae, the mesenchymal cells grow between the epidermis and spinal cord to form a line of periodical condensations, which are proximal radial primordia, to produce chondrocytes. The prescleroblasts, which ossify the proximal radial cartilages, differentiate in the mesenchymal cells remaining between the cartilages. Then, mesenchymal condensations occur between the distal ends of the proximal radials, forming distal radial primordia, to produce chondrocytes. Simultaneously, condensations occur between the distal radial primordia and peridermis, which are lepidotrichia primordia, to produce prescleroblasts. Exogenous RA specifically inhibits the mesenchymal condensation prior to the proximal radial formation together with the down-regulation of sonic hedgehog (shh) and patched (pta) expression, resulting in the loss of proximal radials. Thus, it was indicated that differentiation of the precursor cells of radials and lepidotrichia begins in the proximal part of the fin fold and that the initial mesenchymal condensation prior to the proximal radial formation is highly susceptible to the effects of RA. Lepidotrichia formation does not occur where proximal radials are absent, indicating that lepidotrichia differentiation requires interaction with the radial cartilages. To examine the suggestion that neural crest cells contribute to the medial fin skeletons, we localized the HNK-1 positive cells in flounder embryos and slug and
Investigation of internally finned LED heat sinks

Science.gov (United States)

Li, Bin; Xiong, Lun; Lai, Chuan; Tang, Yumei

2018-03-01

A novel heat sink is proposed, which is composed of a perforated cylinder and internally arranged fins. Numerical studies are performed on the natural convection heat transfer from internally finned heat sinks; experimental studies are carried out to validate the numerical results. To compare the thermal performances of internally finned heat sinks and externally finned heat sinks, the effects of the overall diameter, overall height, and installation direction on maximum temperature, air flow and heat transfer coefficient are investigated. The results demonstrate that internally finned heat sinks show better thermal performance than externally finned heat sinks; the maximum temperature of internally finned heat sinks decreases by up to 20% compared with the externally finned heat sinks. The existence of a perforated cylinder and the installation direction of the heat sink affect the thermal performance significantly; it is shown that the heat transfer coefficient of the heat sink with the perforated cylinder is improved greater than that with the imperforated cylinder by up to 34%, while reducing the mass of the heat sink by up to 13%. Project supported by the Scientific Research Fund of Sichuan Provincial Education Department (No. 18ZB0516) and the Sichuan University of Arts and Science (No. 2016KZ009Y).
Role of Pectoral Fin Flexibility in Robotic Fish Performance

Science.gov (United States)

Bazaz Behbahani, Sanaz; Tan, Xiaobo

2017-08-01

Pectoral fins play a vital role in the maneuvering and locomotion of fish, and they have become an important actuation mechanism for robotic fish. In this paper, we explore the effect of flexibility of robotic fish pectoral fins on the robot locomotion performance and mechanical efficiency. A dynamic model for the robotic fish is presented, where the flexible fin is modeled as multiple rigid elements connected via torsional springs and dampers. Blade element theory is used to capture the hydrodynamic force on the fin. The model is validated with experimental results obtained on a robotic fish prototype, equipped with 3D-printed fins of different flexibility. The model is then used to analyze the impacts of fin flexibility and power/recovery stroke speed ratio on the robot swimming speed and mechanical efficiency. It is found that, in general, flexible fins demonstrate advantages over rigid fins in speed and efficiency at relatively low fin-beat frequencies, while rigid fins outperform flexible fins at higher frequencies. For a given fin flexibility, the optimal frequency for speed performance differs from the optimal frequency for mechanical efficiency. In addition, for any given fin, there is an optimal power/recovery stroke speed ratio, typically in the range of 2-3, that maximizes the speed performance. Overall, the presented model offers a promising tool for fin flexibility and gait design, to achieve speed and efficiency objectives for robotic fish actuated with pectoral fins.
The shark's fin

International Nuclear Information System (INIS)

Listinsky, J.L.; Griffiths, H.J.

1989-01-01

Initial plain film studies of seven patients with facet fracture-dislocations of the cervical spine were examined retrospectively. Rotation of the cross-table lateral film from a standard vetical viewing orientation to a simulated brow-down position allowed easier appreciation of the dislocated pillar in six of the seven patients. The displaced pillar had an appearance similar to that of the dorsal fin of a shark. We conclude that the finding of a shark's fin appearance of an articular pillar in a traumatized patient warrants further radiographic studies. (author). 8 refs.; 3 figs
Room to high temperature measurements of flexible SOI FinFETs with sub-20-nm fins

KAUST Repository

Diab, Amer El Hajj

2014-12-01

We report the temperature dependence of the core electrical parameters and transport characteristics of a flexible version of fin field-effect transistor (FinFET) on silicon-on-insulator (SOI) with sub-20-nm wide fins and high-k/metal gate-stacks. For the first time, we characterize them from room to high temperature (150 °C) to show the impact of temperature variation on drain current, gate leakage current, and transconductance. Variation of extracted parameters, such as low-field mobility, subthreshold swing, threshold voltage, and ON-OFF current characteristics, is reported too. Direct comparison is made to a rigid version of the SOI FinFETs. The mobility degradation with temperature is mainly caused by phonon scattering mechanism. The overall excellent devices performance at high temperature after release is outlined proving the suitability of truly high-performance flexible inorganic electronics with such advanced architecture.
Comparison of optimised endovaginal vs external array coil T2-weighted and diffusion-weighted imaging techniques for detecting suspected early stage (IA/IB1) uterine cervical cancer

Energy Technology Data Exchange (ETDEWEB)

Downey, Kate; Morgan, Veronica A.; Giles, Sharon L.; MacDonald, A.; DeSouza, Nandita M. [The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, CRUK Cancer Imaging Centre, Surrey (United Kingdom); Attygalle, Ayoma D. [The Royal Marsden NHS Foundation Trust, Department of Histopathology, London (United Kingdom); Davis, M. [Kingston Hospital, Department of Gynaecology, Kingston-upon-Thames, Surrey (United Kingdom); Ind, Thomas E.J.; Shepherd, John H. [The Royal Marsden NHS Foundation Trust, Gynecology Unit, London (United Kingdom)

2016-04-15

To compare sensitivity and specificity of endovaginal versus external-array coil T2-W and T2-W + DWI for detecting and staging small cervical tumours. Optimised endovaginal and external array coil MRI at 3.0-T was done prospectively in 48 consecutive patients with stage Ia/Ib1 cervical cancer. Sensitivity/specificity for detecting tumour and parametrial extension against histopathology for a reading radiologist were determined on coronal T2-W and T2W + DW images. An independent radiologist also scored T2-W images without and with addition of DWI for the external-array and endovaginal coils on separate occasions >2 weeks apart. Cohen's kappa assessed inter- and intra-observer agreement. Median tumour volume in 19/38 cases positive on subsequent histology was 1.75 cm{sup 3}. Sensitivity, specificity, PPV, NPV were: reading radiologist 91.3 %, 89.5 %, 91.3 %, 89.5 %, respectively; independent radiologist T2-W 82.6 %, 73.7 %, 79.1 %, 77.8 % for endovaginal, 73.9 %, 89.5 %, 89.5 %, 73.9 % for external-array coil. Adding DWI improved sensitivity and specificity of endovaginal imaging (78.2 %, 89.5 %); adding DWI to external-array imaging improved specificity (94.7 %) but reduced sensitivity (66.7 %). Inter- and intra-observer agreement on T2-W + DWI was good (kappa = 0.67 and 0.62, respectively). Endovaginal coil T2-W MRI is more sensitive than external-array coil for detecting tumours <2 cm{sup 3}; adding DWI improves specificity of endovaginal imaging but reduces sensitivity of external-array imaging. (orig.)
2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani.

Science.gov (United States)

Carballeira, Néstor M; Cartagena, Michelle; Sanabria, David; Tasdemir, Deniz; Prada, Christopher F; Reguera, Rosa M; Balaña-Fouce, Rafael

2012-10-01

2-Alkynoic fatty acids display antimycobacterial, antifungal, and pesticidal activities but their antiprotozoal activity has received little attention. In this work we synthesized the 2-octadecynoic acid (2-ODA), 2-hexadecynoic acid (2-HDA), and 2-tetradecynoic acid (2-TDA) and show that 2-ODA is the best inhibitor of the Leishmania donovani DNA topoisomerase IB enzyme (LdTopIB) with an EC(50)=5.3±0.7μM. The potency of LdTopIB inhibition follows the trend 2-ODA>2-HDA>2-TDA, indicating that the effectiveness of inhibition depends on the fatty acid carbon chain length. All of the studied 2-alkynoic fatty acids were less potent inhibitors of the human topoisomerase IB enzyme (hTopIB) as compared to LdTopIB. 2-ODA also displayed in vitro activity against Leishmania donovani (IC(50)=11.0μM), but it was less effective against other protozoa, Trypanosoma cruzi (IC(50)=48.1μM) and Trypanosoma brucei rhodesiense (IC(50)=64.5μM). The antiprotozoal activity of the 2-alkynoic fatty acids, in general, followed the trend 2-ODA>2-HDA>2-TDA. The experimental information gathered so far indicates that 2-ODA is a promising antileishmanial compound. Copyright © 2012 Elsevier Ltd. All rights reserved.

Stages of Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer

Science.gov (United States)

... diagnosed, tests are done to find out if cancer cells have spread within the ovaries or to other parts of the body. The ... single ovary or fallopian tube. In stage IB, cancer is found inside both ovaries or fallopian tubes. In stage IC, cancer is ...
A Biologically Derived Pectoral Fin for Yaw Turn Manoeuvres

Directory of Open Access Journals (Sweden)

Jonah R. Gottlieb

2010-01-01

Full Text Available A bio-robotic fin has been developed that models the pectoral fin of the bluegill sunfish as the fish turned to avoid an obstacle. This work involved biological studies of the sunfish fin, the development of kinematic models of the motions of the fin's rays, CFD based predictions of the 3D forces and flows created by the fin, and the implementation of simplified models of the fin's kinematics and mechanical properties in a physical model. The resulting robotic fin produced the forces and flows that drove the manoeuvre and had a sufficiently high number of degrees of freedom to create a variety of non-biologically derived motions. The results indicate that for robotic fins to produce a level of performance on par with biological fins, both the kinematics and the mechanical properties of the biological fin must be modelled well.
Parametric CFD Analysis to Study the Influence of Fin Geometry on the Performance of a Fin and Tube Heat Exchanger

DEFF Research Database (Denmark)

Singh, Shobhana; Sørensen, Kim; Condra, Thomas Joseph

2016-01-01

Heat transfer and pressure loss characteristics of a fin and tube heat exchanger are numerically investigated based on parametric fin geometry. The cross-flow type heat exchanger with circular tubes and rectangular fin profile is selected as a reference design. The fin geometry is varied using...... a design aspect ratio as a variable parameter in a range of 0.1-1.0 to predict the impact on overall performance of the heat exchanger. In this paper, geometric profiles with a constant thickness of fin base are studied. Three-dimensional, steady state CFD model is developed using commercially available...... are determined. The best performed geometric fin profile based on the higher heat transfer and lower pressure loss is predicted. The study provides insights into the impact of fin geometry on the heat transfer performance which help escalate the understanding of heat exchanger designing and manufacturing...
Influence of margin status and radiation on recurrence after radical hysterectomy in Stage IB cervical cancer

International Nuclear Information System (INIS)

Viswanathan, Akila N.; Lee, Hang; Hanson, Emily; Berkowitz, Ross S.; Crum, Christopher P.

2006-01-01

Purpose: To examine the relationship between margin status and local recurrence (LR) or any recurrence after radical hysterectomy (RH) in women treated with or without radiotherapy (RT) for Stage IB cervical carcinoma. Methods and Materials: This study included 284 patients after RH with assessable margins between 1980 and 2000. Each margin was scored as negative (≥1 cm), close (>0 and <1 cm), or positive. The outcomes measured were any recurrence, LR, and relapse-free survival. Results: The crude rate for any recurrence was 11%, 20%, and 38% for patients with negative, close, and positive margins, respectively. The crude rate for LR was 10%, 11%, and 38%, respectively. Postoperative RT decreased the rate of LR from 10% to 0% for negative, 17% to 0% for close, and 50% to 25% for positive margins. The significant predictors of decreased relapse-free survival on univariate analysis were the depth of tumor invasion (hazard ratio [HR] 2.14/cm increase, p = 0.007), positive margins (HR 3.92, p = 0.02), tumor size (HR 1.3/cm increase, p = 0.02), lymphovascular invasion (HR 2.19, p = 0.03), and margin status (HR 0.002/increasing millimeter from cancer for those with close margins, p = 0.03). Long-term side effects occurred in 8% after RH and 19% after RH and RT. Conclusion: The use of postoperative RT may decrease the risk of LR in patients with close paracervical margins. Patients with other adverse prognostic factors and close margins may also benefit from the use of postoperative RT. However, RT after RH may increase the risk of long-term side effects
Implications of inaccurate clinical nodal staging in pancreatic adenocarcinoma.

Science.gov (United States)

Swords, Douglas S; Firpo, Matthew A; Johnson, Kirsten M; Boucher, Kenneth M; Scaife, Courtney L; Mulvihill, Sean J

2017-07-01

Many patients with stage I-II pancreatic adenocarcinoma do not undergo resection. We hypothesized that (1) clinical staging underestimates nodal involvement, causing stage IIB to have a greater percent of resected patients and (2) this stage-shift causes discrepancies in observed survival. The Surveillance, Epidemiology, and End Results (SEER) research database was used to evaluate cause-specific survival in patients with pancreatic adenocarcinoma from 2004-2012. Survival was compared using the log-rank test. Single-center data on 105 patients who underwent resection of pancreatic adenocarcinoma without neoadjuvant treatment were used to compare clinical and pathologic nodal staging. In SEER data, medium-term survival in stage IIB was superior to IB and IIA, with median cause-specific survival of 14, 9, and 11 months, respectively (P < .001). Seventy-two percent of stage IIB patients underwent resection vs 28% in IB and 36% in IIA (P < .001). In our institutional data, 12.4% of patients had clinical evidence of nodal involvement vs 69.5% by pathologic staging (P < .001). Among clinical stage IA-IIA patients, 71.6% had nodal involvement by pathologic staging. Both SEER and institutional data support substantial underestimation of nodal involvement by clinical staging. This finding has implications in decisions regarding neoadjuvant therapy and analysis of outcomes in the absence of pathologic staging. Copyright © 2017 Elsevier Inc. All rights reserved.
Effect of fin pitch and number of tube rows on the air side performance of herringbone wavy fin and tube heat exchangers

International Nuclear Information System (INIS)

Wongwises, Somchai; Chokeman, Yutasak

2005-01-01

An experimental study is conducted to investigate the effects of a fin pitch and number of tube rows on the air side performance of fin and tube heat exchangers having herringbone wavy fin configuration at various fin thicknesses. A total of 10 samples of fin and tube heat exchanger with a tube outside diameter of 9.53mm, transverse tube pitch of 25.4mm and longitudinal tube pitch of 19.05mm, having various fin pitches, number of tube rows and fin thicknesses, are tested in a well insulated open wind tunnel. The heat exchangers are made from aluminium plate finned, copper tube. Ambient air is used as a working fluid in the air side while hot water is used for the tube side. The results are presented as the variation of the Colburn factor and the friction factor with the Reynolds number based on the fin collar outside diameter (Re D c ). The experimental results reveal that the fin pitch has an insignificant effect on the heat transfer characteristic. The friction factor increases with increasing fin pitch when Re D c >2500, approximately. The Colburn factor and the friction factor decrease with increasing number of tube rows when Re D c <4000, approximately. These results remain the same when the fin thickness is changed
Performance of tubes-and plate fins heat exchangers

International Nuclear Information System (INIS)

Rosman, E.C.

1979-11-01

By means of a two-dimensional analysis performance, and using local heat transfer coefficients, the plate fin temperature distribution, the air bulk temperature along the stream path and the fin efficiency can be obtained, for several Reynolds numbers and fin materials. Herein are also presented the average heat transfer coefficients for isothermal plate fins, referring to heat exchangers with central-tube and rear-tube row and to two-row tubes heat exchangers configurations. It is possible to obtain the real tax or the real area of heat transfer, using the average hea transfer coefficients for isothermal plate fins and the fin efficiency. (Author) [pt
Fish locomotion: kinematics and hydrodynamics of flexible foil-like fins

Science.gov (United States)

Lauder, George V.; Madden, Peter G. A.

2007-11-01

The fins of fishes are remarkable propulsive devices that appear at the origin of fishes about 500 million years ago and have been a key feature of fish evolutionary diversification. Most fish species possess both median (midline) dorsal, anal, and caudal fins as well as paired pectoral and pelvic fins. Fish fins are supported by jointed skeletal elements, fin rays, that in turn support a thin collagenous membrane. Muscles at the base of the fin attach to and actuate each fin ray, and fish fins thus generate their own hydrodynamic wake during locomotion, in addition to fluid motion induced by undulation of the body. In bony fishes, the jointed fin rays can be actively deformed and the fin surface can thus actively resist hydrodynamic loading. Fish fins are highly flexible, exhibit considerable deformation during locomotion, and can interact hydrodynamically during both propulsion and maneuvering. For example, the dorsal and anal fins shed a vortex wake that greatly modifies the flow environment experienced by the tail fin. New experimental kinematic and hydrodynamic data are presented for pectoral fin function in bluegill sunfish. The highly flexible sunfish pectoral fin moves in a complex manner with two leading edges, a spanwise wave of bending, and substantial changes in area through the fin beat cycle. Data from scanning particle image velocimetry (PIV) and time-resolved stereo PIV show that the pectoral fin generates thrust throughout the fin beat cycle, and that there is no time of net drag. Continuous thrust production is due to fin flexibility which enables some part of the fin to generate thrust at all times and to smooth out oscillations that might arise at the transition from outstroke to instroke during the movement cycle. Computational fluid dynamic analyses of sunfish pectoral fin function corroborate this conclusion. Future research on fish fin function will benefit considerably from close integration with studies of robotic model fins.
HLA class Ib in pregnancy and pregnancy-related disorders.

Science.gov (United States)

Persson, Gry; Melsted, Wenna Nascimento; Nilsson, Line Lynge; Hviid, Thomas Vauvert F

2017-08-01

The HLA class Ib genes, HLA-E, HLA-F, and HLA-G, were discovered long after the classical HLA class Ia genes. The elucidation of their functions had a modest beginning. However, their basic functions and involvement in pathophysiology and a range of diseases are now emerging. Although results from a range of studies support the functional roles for the HLA class Ib molecules in adult life, especially HLA-G and HLA-F have most intensively been, and were also primarily, studied in relation to reproduction and pregnancy. The expression of HLA class Ib proteins at the feto-maternal interface in the placenta seems to be important for the maternal acceptance of the semi-allogenic fetus. In contrast to the functions of HLA class Ia, HLA-G possesses immune-modulatory and tolerogenic functions. Here, we review an accumulating amount of data describing the functions of HLA class Ib molecules in relation to fertility, reproduction, and pregnancy, and a possible role for these molecules in certain pregnancy complications, such as implantation failure, recurrent spontaneous abortions, and pre-eclampsia. The results from different kinds of studies point toward a role for HLA class Ib, especially HLA-G, throughout the reproductive cycle from conception to the birth weight of the child.
Interactive Gentle Yoga in Improving Quality of Life in Patients With Stage I-III Breast Cancer Undergoing Radiation Therapy

Science.gov (United States)

2017-07-28

Anxiety Disorder; Depression; Ductal Breast Carcinoma in Situ; Fatigue; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
La religión ibérica a través de las necrópolis

Directory of Open Access Journals (Sweden)

María Paz GARCIA-GELABERT PÉREZ

2009-10-01

Full Text Available La religión ibérica parece ser religión de un gran pragmatismo. Las normas religiosas de comportamiento de todas las sociedades de tecnología simple se centran, sobre todo, en las incertidumbres de la existencia. El hombre de tales sociedades es más instintivo que el de niveles superiores, de ahí que su religión esté impregnada de un alto grado de naturalismo. Prioritariamente sus cultos son paralelos a las manifestaciones generales que constituyen la base de su vida material: el cielo, las estaciones cambiantes, los fenómenos atmosféricos, lluvias, vientos, tormentas, terremotos; la tierra y sus frutos exteriores e interiores, los animales, etc. Como escribe M. Eliade1, «en los niveles arcaicos de la cultura general de la humanidad el vivir del ser humano es ya de por sí un acto religioso, pues tomar alimento, ejercer la sexualidad y trabajar, son actos de un valor sacramental».
Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS.

Science.gov (United States)

Di Nardo, G; Barbara, G; Cucchiara, S; Cremon, C; Shulman, R J; Isoldi, S; Zecchi, L; Drago, L; Oliva, S; Saulle, R; Barbaro, M R; Stronati, L

2014-02-01

Neuroimmune interactions and inflammation have been proposed as factors involved in sensory-motor dysfunction and symptom generation in adult irritable bowel syndrome (IBS) patients. In children with IBS and healthy controls, we measured ileocolonic mast cell infiltration and fecal calprotectin and evaluated the relationships between these parameters and abdominal pain symptoms and stooling pattern. Irritable bowel syndrome patients diagnosed according to Pediatric Rome III criteria and healthy controls kept a 2-week pain/stooling diary. Ileocolonic mucosal mast cells (MC) and MC in close proximity to nerve fibers (MC-NF) were identified immunohistochemically and quantified. Fecal calprotectin concentration was measured. 21 IBS patients and 10 controls were enrolled. The MC-NF count was significantly higher in the ileum (p = 0.01), right colon (p = 0.04), and left colon (p Abdominal pain intensity score correlated with ileal MC count (r(s) = 0.47, p = 0.030) and right colon MC-NF count (r(s) = 0.52, p = 0.015). In addition, children with IBS with >3 abdominal pain episodes/week had greater ileal (p = 0.002) and right colonic (p = 0.01) MC counts and greater ileal (p = 0.05) and right colonic (p = 0.016) MC-NF counts than children with less frequent pain. No relationship was found between MC and MC-NF and fecal calprotectin or stooling pattern. Mast cells-nerve fibers counts are increased in the ileocolonic mucosa of children with IBS. Mast cells and MC-NF counts are related to the intensity and frequency of abdominal pain. © 2013 John Wiley & Sons Ltd.
FinFET modeling for IC simulation and design

CERN Document Server

Hu, Chenming; Lu, Darsen D

2015-01-01

This book is the first to explain FinFET modeling for IC simulation and the industry standard - BSIM-CMG - describing the rush in demand for advancing the technology from planar to 3D architecture, as now enabled by the approved industry standard. The book gives a strong foundation on the physics and operation of FinFET, details aspects of the BSIM-CMG model such as surface potential, charge and current calculations, and includes a dedicated chapter on parameter extraction procedures, providing a step-by-step approach for the efficient extraction of model parameters. With this book you will learn: * Why you should use FinFET* The physics and operation of FinFET* Details of the FinFET standard model (BSIM-CMG)* Parameter extraction in BSIM-CMG* FinFET circuit design and simulation * Authored by the lead inventor and developer of FinFET, and developers of the BSIM-CM standard model, providing an experts' insight into the specifications of the standard* The first book on the industry-standard FinFET model - BSIM...
Intravital Microscopy for Identifying Tumor Vessels in Patients With Stage IA-IV Melanoma That is Being Removed by Surgery

Science.gov (United States)

2017-06-05

Recurrent Melanoma; Stage IA Skin Melanoma; Stage IB Skin Melanoma; Stage IIA Skin Melanoma; Stage IIB Skin Melanoma; Stage IIC Skin Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma
Erfolgreiche Ambivalenz. Sarah Bernhardts Inszenierungen von Weiblichkeit Successful Ambivalence: Sarah Bernhardt’s Staging of Femininity

Directory of Open Access Journals (Sweden)

Doris Kolesch

2007-03-01

Full Text Available Claudia Thorun untersucht die Inszenierungen von Weiblichkeit am Beispiel der Schauspielerin Sarah Bernhardt, die im späten 19. und beginnenden 20. Jahrhundert zu den erfolgreichsten Künstlerinnen ihrer Zeit gehörte. Dazu werden die Darstellungen ausgewählter Rollenfiguren ebenso analysiert wie die schauspieltheoretischen Überlegungen Bernhardts und schließlich die Rezeption ihres Schaffens in Theaterkritiken, aber auch Werbebildern und Medieninszenierungen. Das lesenswerte Buch erlaubt Einblicke in konkrete theatrale Verkörperungen von Weiblichkeit im Fin de Siècle, unternimmt jedoch keine ausreichende theatergeschichtliche wie kulturwissenschaftliche Kontextualisierung, obwohl die Verfasserin in der Einleitung ihrer Studie das Ziel formuliert, Gendertheorie, Theatergeschichte und Kulturwissenschaft zu verknüpfen.Claudia Thorun examines the staging of femininity using the example of the actress Sarah Bernhardt, who in the late nineteenth century was among the most successful artists of her time. The study includes analyses of the representation of specific roles, Bernhardt’s theories on acting, and finally the reception of her work in theater critiques, as well as advertisement images and representations in the media. The book, which is a worthwhile read, allows for insight into the concrete theatrical embodiment of femininity at the fin de siècle. It does not provide, however, adequate contextualization within theater history nor cultural studies, even though in her introduction, the author asserts that it is her intention to link together gender theory, theater history, and cultural studies.
Vicente Blasco Ibáñez (1867-1928: viaje por Oriente y Egipto

Directory of Open Access Journals (Sweden)

Lara Peinado, Federico

2005-04-01

Full Text Available Con este artículo se pretende rememorar los viajes efectuados a Turquía (1907 y años después al país del Nilo (1924 por el famoso novelista Vicente Blasco Ibáñez (1867-1928. Sus impresiones, la historia de los países visitados, la descripción de sus ciudades y paisajes tomaron cuerpo en las obras tituladas Oriente y La vuelta al mundo de un novelista. Blasco Ibáñez supo resumir la historia de Constantinopla así como la de Egipto -especialmente su antigüedad- con sencillas palabras, sin tecnicismos, haciendo llegar al lector el impacto que le causaron monumentos y ambientes de la ciudad turca en un caso, y las pirámides, tumbas y el paisaje nilotico en otro, además de introducirlo en el alma de sus gentes.…
Post-operative high dose rate vaginal apex brachytherapy in stage I endometrial adenocarcinoma

International Nuclear Information System (INIS)

Gumbs, A.A.; Turner, B.C.; Knisely, J.P.S.; Kacinski, B.M.; Roberts, K.B.; Peschel, R.E.; Haffty, B.G.; Rutherford, T.J.; Edraki, B.; Schwartz, P.E.; Wilson, L.D.

1996-01-01

Purpose/Objective: Patients with Stage I endometrial adenocarcinoma have traditionally been treated with total abdominal hysterectomy/bilateral salpingo-oophorectomy and radiation. The reported incidence of local recurrence in surgically treated patients with FIGO Stage IA or IB endometrial adenocarcinoma is 4-10% at 2 years. Combined surgery and radiation has resulted in a reduction of recurrence to 2-6%. We report the presentation, actuarial survival, actuarial rate of local failure, salvage rate, and complications for patients undergoing high dose rate (HDR) vaginal apex brachytherapy following surgery. Materials and Methods: Between 1985 and 1994 a total of 286 patients with FIGO Stage I endometrioid uterine adenocarcinoma were treated with HDR Ir-192 vaginal apex brachytherapy alone to a total dose of 21 Gy in 3 fractions at 0.5 cm from the vaginal mucosa. The pathologic stage by treatment group was IA: 31%, IB: 68%, and IC: 1%. The histologic grade of the patient's tumors was grade 1: 69%, 2: 29%, and 3: 2% of patients. The median time from surgery to radiation was 34 days (range 14-66 days). The median follow-up for 286 patients with Stage IA (92 patients), IB (190 patients), and IC (4 patients) was respectively, 37, 35 and 40 months (2 patients lost to follow-up prior to 6 months). Results: Patients presented with vaginal bleeding (94%) or abnormal pap smear (6%) at a median age for Stage IA and IB, of 54 and 63 years, respectively (range 32-88). The 5-year overall actuarial survival rate was 94.5%. The 5-year actuarial survival rate by histologic grade was 97.5% and 91.5% for FIGO grade 1 and 2, respectively (p=.011). The 5-year actuarial survival rate by depth of myometrial invasion was 99.0% and 92.5% for Stage IA and IB, respectively (p=.029). Median overall time to failure is 19.5 months (range 10-36 months). The 5-year actuarial rate of local failure was 4.5%. The overall failure rate in our study group was 2.8% (8 patients), local failure only 1
Eddy current test of fin tubes for a heat exchanger

International Nuclear Information System (INIS)

KIm, Young Joo; Lee, Se Kyung; Chung, Min Hwa

1992-01-01

Eddy current probes were designed for the test of fin tubes. Fin tubes, often used for heat exchangers, have uneven outer and inner surfaces to enhance the heat emission. The surface roughness make it difficult to detect flaws employing eddy current test(ECT). In order to overcome the difficulties we performed two types of works, one is the delopment of ECT probes, and the other is the signal processing including fast Fourier transform and digital filtering. In the development of ECT probes, we adopted empirical design method. Our ECT probes for fin tubes are inside diameter type. And we are specially concerned about geometric features such as the widths of the coils composing an ECT probe. We fabricated four probes with various coil widths. Eddy current test was performed using those ECT probes on specimens with artificial flaws. After analyzing the output signals, we found that, in order for the effective testing, the width of a coil should be determined considering the pitch of the fins of a tube. And we also learned that the frequency filtering could improve the s/n ratio.
A biorobotic pectoral fin for autonomous undersea vehicles.

Science.gov (United States)

Tangorra, James L; Davidson, S Naomi; Madden, Peter G; Lauder, George V; Hunter, Ian W

2006-01-01

A biorobotic fin for autonomous undersea vehicles (AUVs) was developed based on studies of the anatomy, kinematics, and hydrodynamics of the bluegill sunfish pectoral fin. The biorobotic fin was able to produce many of the complex fin motions used by the sunfish during steady swimming and was used to investigate mechanisms of thrust production and control. This biorobotic fin is an excellent experimental tool and is an important first step towards developing propulsive devices that give AUVs maneuvering characteristics that match and exceed those of highly maneuverable fish.
Expression of the sweetpotato R2R3-type IbMYB1a gene induces anthocyanin accumulation in Arabidopsis.

Science.gov (United States)

Chu, Hyosub; Jeong, Jae Cheol; Kim, Wook-Jin; Chung, Dong Min; Jeon, Hyo Kon; Ahn, Young Ock; Kim, Sun Ha; Lee, Haeng-Soon; Kwak, Sang-Soo; Kim, Cha Young

2013-06-01

R2R3-type MYB transcription factors (TFs) play important roles in transcriptional regulation of anthocyanins. The R2R3-type IbMYB1 is known to be a key regulator of anthocyanin biosynthesis in the storage roots of sweetpotato. We previously showed that transient expression of IbMYB1a led to anthocyanin pigmentation in tobacco leaves. In this article, we generated transgenic Arabidopsis plants expressing the IbMYB1a gene under the control of CaMV 35S promoter, and the sweetpotato SPO and SWPA2 promoters. Overexpression of IbMYBa in transgenic Arabidopsis produced strong anthocyanin pigmentation in seedlings and generated a deep purple color in leaves, stems and seeds. Reverse transcription-polymerase chain reaction analysis showed that IbMYB1a expression induced upregulation of several structural genes in the anthocyanin biosynthetic pathway, including 4CL, CHI, F3'H, DFR, AGT, AAT and GST. Furthermore, overexpression of IbMYB1a led to enhanced expression of the AtTT8 (bHLH) and PAP1/AtMYB75 genes. high-performance liquid chromatography analysis revealed that IbMYB1a expression led to the production of cyanidin as a major core molecule of anthocyanidins in Arabidopsis, as occurs in the purple leaves of sweetpotato (cv. Sinzami). This result shows that the IbMYB1a TF is sufficient to induce anthocyanin accumulation in seedlings, leaves, stems and seeds of Arabidopsis plants. Copyright © Physiologia Plantarum 2012.

Puñales de antenas en territorio ibérico

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Emeterio CUADRADO

2009-10-01

Full Text Available Así como en la zona peninsular ocupada por los iberos históricos encontramos la falcata como su espada peculiar, en las Mesetas y otros lugares del país, habitados por los invasores Célticos, hallamos en la segunda Edad del Hierro, la de antenas. La introducción de espadas de la Tene, que debe comenzar en el s. IV a. J. C, se hace más intensa en el mundo ibérico que en el céltico.
Intravital Microscopy in Evaluating Patients With Primary Peritoneal, Fallopian Tube, or Stage IA-IV Ovarian Cancer

Science.gov (United States)

2018-06-04

Fallopian Tube Carcinoma; Primary Peritoneal Carcinoma; Stage I Ovarian Cancer; Stage IA Ovarian Cancer; Stage IB Ovarian Cancer; Stage IC Ovarian Cancer; Stage II Ovarian Cancer; Stage IIA Ovarian Cancer; Stage IIB Ovarian Cancer; Stage IIC Ovarian Cancer; Stage III Ovarian Cancer; Stage IIIA Ovarian Cancer; Stage IIIB Ovarian Cancer; Stage IIIC Ovarian Cancer; Stage IV Ovarian Cancer
Health and Recovery Program in Increasing Physical Activity Level in Stage IA-IIIA Endometrial Cancer Survivors

Science.gov (United States)

2018-03-05

Cancer Survivor; Endometrial Carcinoma; Stage I Uterine Corpus Cancer AJCC v7; Stage IA Uterine Corpus Cancer AJCC v7; Stage IB Uterine Corpus Cancer AJCC v7; Stage II Uterine Corpus Cancer AJCC v7; Stage IIIA Uterine Corpus Cancer AJCC v7
An IPMC-enabled bio-inspired bending/twisting fin for underwater applications

Science.gov (United States)

Palmre, Viljar; Hubbard, Joel J.; Fleming, Maxwell; Pugal, David; Kim, Sungjun; Kim, Kwang J.; Leang, Kam K.

2013-01-01

This paper discusses the design, fabrication, and characterization of an ionic polymer-metal composite (IPMC) actuator-based bio-inspired active fin capable of bending and twisting motion. It is pointed out that IPMC strip actuators are used in the simple cantilever configuration to create simple bending (flapping-like) motion for propulsion in underwater autonomous systems. However, the resulting motion is a simple 1D bending and performance is rather limited. To enable more complex deformation, such as the flapping (pitch and heaving) motion of real pectoral and caudal fish fins, a new approach which involves molding or integrating IPMC actuators into a soft boot material to create an active control surface (called a ‘fin’) is presented. The fin can be used to realize complex deformation depending on the orientation and placement of the actuators. In contrast to previously created IPMCs with patterned electrodes for the same purpose, the proposed design avoids (1) the more expensive process of electroless plating platinum all throughout the surface of the actuator and (2) the need for specially patterning the electrodes. Therefore, standard shaped IPMC actuators such as those with rectangular dimensions with varying thicknesses can be used. One unique advantage of the proposed structural design is that custom shaped fins and control surfaces can be easily created without special materials processing. The molding process is cost effective and does not require functionalizing or ‘activating’ the boot material similar to creating IPMCs. For a prototype fin (90 mm wide × 60 mm long × 1.5 mm thick), the measured maximum tip displacement was approximately 44 mm and the twist angle of the fin exceeded 10°. Lift and drag measurements in water where the prototype fin with an airfoil profile was dragged through water at a velocity of 21 cm s-1 showed that the lift and drag forces can be affected by controlling the IPMCs embedded into the fin structure. These
Investigating the effect of non-similar fins in thermoeconomic optimization of plate fin heat exchanger

International Nuclear Information System (INIS)

Hajabdollahi, Hassan

2015-01-01

Thermoeconomic optimization of plate fin heat exchanger with similar (SF) and different (DF) or non-similar fin in each side is presented in this work. For this purpose, both heat exchanger effectiveness and total annual cost (TAC) are optimized simultaneously using multi-objective particle swarm optimization algorithm. The above procedure is performed for various mass flow rates in each side. The optimum results reveal that no thermoeconomic improvement is observed in the case of same mass flow rate in each side while both effectiveness and TAC are improved in the case of different mass flow rate. For example, effectiveness and TAC are improved 0.95% and 10.17% respectively, for the DF compared with SF. In fact, the fin configuration should be selected more compact in a side with lower mass flow rate compared with the other side in the thermoeconomic viewpoint. Furthermore, for the thermodynamic optimization viewpoint both SF and DF have the same optimum result while for the economic (or thermoeconomic) optimization viewpoint, the significant decrease in TAC is accessible in the case of DF compared with SF. - Highlights: • Thermoeconomic modeling of compact heat exchanger. • Selection of fin and heat exchanger geometries as nine decision variables. • Applying MOPSO algorithm for multi objective optimization. • Considering the similar and different fin specification in each side. • Investigation of optimum design parameters for various mass flow rates
Medically inoperable stage I endometrial carcinoma: a few dilemmas in radiotherapeutic management

International Nuclear Information System (INIS)

Chao, Clifford K. S.; Grigsby, Perry W.; Perez, Carlos A.; Mutch, David G.; Herzog, Thomas; Camel, H. Marvin

1996-01-01

Purpose: The aggressiveness of radiation therapy for patients with medically inoperable endometrial carcinoma is controversial. Patients may die of their underlining medical disease before succumbing to cancer. We try to identify certain subgroup of patients who might benefit most from an aggressive approach and also investigate the impact of residual tumor present in dilatation and curettage (D and C) specimen obtained in second intracavitary implant (ICI). Methods and Materials: From 1965 to 1990, 101 patients were treated for clinical clinical Stage I endometrial carcinoma with RT alone due to medical problems. Ages ranged from 39 to 94 years (median 71 years). There were 18 patients with clinical Stage IA and 83 with clinical Stage IB disease. Histology included 44 well-differentiated, 37 moderately differentiated, and 20 poorly differentiated tumors. Radiation therapy consisted of external beam only in 3 patients, ICI alone in 26, whole pelvis plus ICI in 10, and whole pelvis plus split field plus ICI in 62. A second D and C was performed on 26 patients at the time of the second ICI. Minimum follow-up was 2 years (median, 6.3 years). Results: The 5-year actuarial disease-free survival (DFS) for the studied cohort is comparable to the expected survival of an age-matched population. Pelvic control was 100% for Stage IA and 88% for Stage IB with 5-year disease-free survivals of 80 and 84%, respectively. We also observed a greater disassociation of DFS and overall survival among patients older than 75 years (84 and 55%, respectively) than in younger patients (84 and 78%, respectively). This is mainly because older patients succumbed to their medical illness. Well-differentiated disease demonstrated the trend toward a better outcome than moderately or poorly differentiated lesions in Stage IB patients (p 0.05), but not in Stage IA patients. Aggressive radiation therapy approach showed the trend toward a better result in Stage IB patients 75 years of age or younger
Flexible nanoscale high-performance FinFETs

KAUST Repository

Sevilla, Galo T.

2014-10-28

With the emergence of the Internet of Things (IoT), flexible high-performance nanoscale electronics are more desired. At the moment, FinFET is the most advanced transistor architecture used in the state-of-the-art microprocessors. Therefore, we show a soft-etch based substrate thinning process to transform silicon-on-insulator (SOI) based nanoscale FinFET into flexible FinFET and then conduct comprehensive electrical characterization under various bending conditions to understand its electrical performance. Our study shows that back-etch based substrate thinning process is gentler than traditional abrasive back-grinding process; it can attain ultraflexibility and the electrical characteristics of the flexible nanoscale FinFET show no performance degradation compared to its rigid bulk counterpart indicating its readiness to be used for flexible high-performance electronics.
Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo

Directory of Open Access Journals (Sweden)

Zhonghan Yang

2012-01-01

Full Text Available Irritable bowel syndrome (IBS is a functional bowel disorder and the etiology is not well understood. Currently there is no cure for IBS and no existing medication induces symptom relief in all patients. IBS-20 is a 20-herb Chinese medicinal formula that offers beneficial effects in patients with IBS; however, the underlying mechanisms are largely unknown. This study showed that IBS-20 potently inhibited LPS- or IFNΓ-stimulated expression of pro-inflammatory cytokines, as well as classically activated macrophage marker nitric oxide synthase 2. Similarly, IBS-20 or the component herb Coptis chinensis decreased LPS-stimulated pro-inflammatory cytokine secretion from JAWS II dendritic cells. IBS-20 or the component herbs also blocked or attenuated the IFNΓ-induced drop in transepithelial electric resistance, an index of permeability, in fully differentiated Caco-2 monolayer. Finally, the up-regulation of key inflammatory cytokines in inflamed colon from TNBS-treated mice was suppressed significantly by orally administrated IBS-20, including IFNΓ and IL-12p40. These data indicate that the anti-inflammatory activities of IBS-20 may contribute to the beneficial effects of the herbal extract in patients with IBS, providing a potential mechanism of action for IBS-20. In addition, IBS-20 may be a potential therapeutic agent against other Th1-dominant gut pathologies such as inflammatory bowel disease.
Implications of fin profiles on overall performance and weight reduction of a fin and tube heat exchanger

DEFF Research Database (Denmark)

Singh, Shobhana; Sørensen, Kim; Simonsen, Anders Schou

2017-01-01

Fin and tube heat exchangers are being used in several industrial applications by means of novel design and optimized performance. Improvements in geometric design may deliver energy efficient and cost-effective heat exchanger performance with reduced weight. In this paper, a systematic study...... on a cross-flow type fin and tube heat exchanger design for a waste heat recovery application is conducted. The geometric profile of the fin is characterized by a dimensionless design variable named aspect ratio which is parametrically varied to obtain different profiles. Two cases, case-I, and case......,000 using computational fluid dynamics. The numerical results obtained for the reference fin profile are verified with the experimental correlations. Dimensionless parameters such as Nusselt number, Euler number, and efficiency index are calculated to predict the overall performance of the heat exchanger...
FinTech in Taiwan: a case study of a Bank's strategic planning for an investment in a FinTech company

OpenAIRE

Hung, Jui-long; Luo, Binjie

2016-01-01

Introduction: Since 2015 is the year of FinTech in Taiwan, it is worth investigating the challenges that emerged when banks were encouraged to invest in FinTech companies for collaboration. This study aims to identify the strategic considerations in the process of searching for FinTech investment targets. Case description: This study used a case study investigation of a top-5 bank in Taiwan. The major data sources include the meeting notes of the FinTech investment task force and interviews w...
The impact of internal longitudinal fins in parabolic trough collectors operating with gases

International Nuclear Information System (INIS)

Bellos, Evangelos; Tzivanidis, Christos; Daniil, Ilias; Antonopoulos, Kimon A.

2017-01-01

Highlights: • In this study, the impact of internal fins in PTC operating with gases is presented. • Air, helium and CO_2 are tested in smooth absorber and with fins of 5–10 mm and 15 mm. • Greater fin length leads to higher thermal efficiency and 10 mm is the optimum length exergetically. • Helium is the best working fluid exergetically, with CO_2 and air to follow. • Up to 290 °C, helium performs better energetically, while CO_2 in higher temperatures. - Abstract: In this study, the use of internal fins in parabolic trough collectors operating with gas working fluids is examined. Air, helium and carbon dioxide are the investigated working fluids, while Eurotrough ET-150 is the examined solar collector. The design and the simulation of this solar collector are performed with the commercial software Solidworks Flow Simulation. The internal fins lead to higher thermal efficiency but also to higher pressure losses; something very important for the solar fields of Concentrated Power Plants. Thus, the collector is examined energetically and exergetically in order to take into account the increase in the useful output with the simultaneous greater need of pumping power. Various fin lengths are examined and finally the fin of 10 mm was proved to be the most appropriate exergetically. In working fluid comparison, helium is the most efficient working fluid exergetically for all the examined cases. In the thermal efficiency comparison, helium performs better up to 290 °C, while carbon dioxide is the best choice in higher temperature levels. Moreover, the optimum mass flow rate for the helium was proved to be 0.03 kg/s and for the other working fluids the value of 0.015 kg/s seems to lead to the most satisfying results.
Undulating fins produce off-axis thrust and flow structures.

Science.gov (United States)

Neveln, Izaak D; Bale, Rahul; Bhalla, Amneet Pal Singh; Curet, Oscar M; Patankar, Neelesh A; MacIver, Malcolm A

2014-01-15

While wake structures of many forms of swimming and flying are well characterized, the wake generated by a freely swimming undulating fin has not yet been analyzed. These elongated fins allow fish to achieve enhanced agility exemplified by the forward, backward and vertical swimming capabilities of knifefish, and also have potential applications in the design of more maneuverable underwater vehicles. We present the flow structure of an undulating robotic fin model using particle image velocimetry to measure fluid velocity fields in the wake. We supplement the experimental robotic work with high-fidelity computational fluid dynamics, simulating the hydrodynamics of both a virtual fish, whose fin kinematics and fin plus body morphology are measured from a freely swimming knifefish, and a virtual rendering of our robot. Our results indicate that a series of linked vortex tubes is shed off the long edge of the fin as the undulatory wave travels lengthwise along the fin. A jet at an oblique angle to the fin is associated with the successive vortex tubes, propelling the fish forward. The vortex structure bears similarity to the linked vortex ring structure trailing the oscillating caudal fin of a carangiform swimmer, though the vortex rings are distorted because of the undulatory kinematics of the elongated fin.
Caloric Restriction in Treating Patients With Stage 0-I Breast Cancer Undergoing Surgery and Radiation Therapy

Science.gov (United States)

2017-09-25

Ductal Breast Carcinoma in Situ; Invasive Ductal Breast Carcinoma; Invasive Lobular Breast Carcinoma; Lobular Breast Carcinoma in Situ; Recurrent Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer
Acupuncture in Reducing Chemotherapy-Induced Peripheral Neuropathy in Participants With Stage I-III Breast Cancer

Science.gov (United States)

2018-05-30

Anatomic Stage I Breast Cancer AJCC v8; Anatomic Stage IA Breast Cancer AJCC v8; Anatomic Stage IB Breast Cancer AJCC v8; Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage IIA Breast Cancer AJCC v8; Anatomic Stage IIB Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IIIA Breast Cancer AJCC v8; Anatomic Stage IIIB Breast Cancer AJCC v8; Anatomic Stage IIIC Breast Cancer AJCC v8; Grade 1 Peripheral Motor Neuropathy, CTCAE; Grade 1 Peripheral Sensory Neuropathy, CTCAE; Grade 2 Peripheral Motor Neuropathy, CTCAE; Grade 2 Peripheral Sensory Neuropathy, CTCAE; Prognostic Stage I Breast Cancer AJCC v8; Prognostic Stage IA Breast Cancer AJCC v8; Prognostic Stage IB Breast Cancer AJCC v8; Prognostic Stage II Breast Cancer AJCC v8; Prognostic Stage IIA Breast Cancer AJCC v8; Prognostic Stage IIB Breast Cancer AJCC v8; Prognostic Stage III Breast Cancer AJCC v8; Prognostic Stage IIIA Breast Cancer AJCC v8; Prognostic Stage IIIB Breast Cancer AJCC v8; Prognostic Stage IIIC Breast Cancer AJCC v8
Performance and cost benefits analysis of double-pass solar collector with and without fins

International Nuclear Information System (INIS)

Fudholi, Ahmad; Sopian, Kamaruzzaman; Ruslan, Mohd Hafidz; Othman, Mohd Yusof

2013-01-01

Highlights: • The thermal performances and cost analysis of the double-pass solar collector with and without fins absorber were discussed. • The theoretical and experimental study on the double-pass solar air collector with and without fins absorber was conducted. • The ratio of AC/AEG or the cost benefit ratio was presented. • The double-pass solar collector with fins absorber is more cost-effective compared to without fins absorber. - Abstract: The performance and cost benefit analysis of double-pass solar collector with and without fins have been conducted. The theoretical model using steady state analysis has been developed and compared with the experimental results. The performance curves of the double-pass solar collector with and without fins, which included the effects of mass flow rate and solar intensity on the thermal efficiency of the solar collector, were obtained. Results indicated that the thermal efficiency is proportional to the solar intensity at a specific mass flow rate. The thermal efficiency increased by 9% at a solar intensity of 425–790 W/m 2 and mass flow rate of 0.09 kg/s. The theoretical and experimental analysis showed a similar trend as well as close agreement. Moreover, a cost-effectiveness model has been developed examine the cost benefit ratio of double-pass solar collector with and without fins. Evaluation of the annual cost (AC) and the annual energy gain (AEG) of the collector were also performed. The results show that the double-pass solar collector with fins is more cost-effective compared to the double-pass solar collector without fins for mass flow rate of 0.01–0.07 kg/s. Also, simulations were obtained for the double-pass solar collector with fins at Nusselt number of 5.42–36.21. The energy efficiency of collector increases with the increase of Nusselt number. The results show that by increasing the Nusselt number simultaneously would drop the outlet temperature at any solar intensity. Increase in Nusselt number
A successful application of homotopy perturbation method for efficiency and effectiveness assessment of longitudinal porous fins

International Nuclear Information System (INIS)

Cuce, Erdem; Cuce, Pinar Mert

2015-01-01

Highlights: • Homotopy perturbation method has been applied to porous fins. • Dimensionless efficiency and effectiveness expressions have been firstly developed. • Effects of porous and convection parameters on thermal analysis have been clarified. • Ratio of porous fin to solid fin heat transfer rate has been given for various cases. • Reliability and practicality of homotopy perturbation method has been illustrated. - Abstract: In our previous works, thermal performance of straight fins with both constant and temperature-dependent thermal conductivity has been investigated in detail and dimensionless analytical expressions of fin efficiency and fin effectiveness have been developed for the first time in literature via homotopy perturbation method. In this study, previous works have been extended to porous fins. Governing equations have been formulated by performing Darcy’s model. Dimensionless temperature distribution along the length of porous fin has been determined as a function of porosity and convection parameters. The ratio of porous fin to solid fin heat transfer rate has also been evaluated as a function of thermo-geometric fin parameter. The results have been compared with those of finite difference method for a specific case and an excellent agreement has been observed. The expressions developed are beneficial for thermal engineers for preliminary assessment of thermophysical systems instead of consuming time in heat conduction problems governed by strongly nonlinear differential equations
Interactive Tailored Website to Promote Sun Protection and Skin Self-Check Behaviors in Patients With Stage 0-III Melanoma

Science.gov (United States)

2017-11-15

Stage 0 Skin Melanoma; Stage I Skin Melanoma; Stage IA Skin Melanoma; Stage IB Skin Melanoma; Stage II Skin Melanoma; Stage IIA Skin Melanoma; Stage IIB Skin Melanoma; Stage IIC Skin Melanoma; Stage III Skin Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma
Experimental study of heat transfer and thermal performance with longitudinal fins of solar air heater.

Science.gov (United States)

Chabane, Foued; Moummi, Noureddine; Benramache, Said

2014-03-01

The thermal performance of a single pass solar air heater with five fins attached was investigated experimentally. Longitudinal fins were used inferior the absorber plate to increase the heat exchange and render the flow fluid in the channel uniform. The effect of mass flow rate of air on the outlet temperature, the heat transfer in the thickness of the solar collector, and the thermal efficiency were studied. Experiments were performed for two air mass flow rates of 0.012 and 0.016 kg s(-1). Moreover, the maximum efficiency values obtained for the 0.012 and 0.016 kg s(-1) with and without fins were 40.02%, 51.50% and 34.92%, 43.94%, respectively. A comparison of the results of the mass flow rates by solar collector with and without fins shows a substantial enhancement in the thermal efficiency.
Innovative Approach for IBS Vendor Selection Problem

Directory of Open Access Journals (Sweden)

Omar Mohd Faizal

2016-01-01

Full Text Available Supply chain management in Industrialised Building System (IBS construction management has significantly determined the successful of company and project performance. Due to the wide variety of criteria and vendor available, the vendor selection process for a specific project needs is becoming more difficult. The need of decision aid for vendor selection in other areas is widely discussed in previous research. However, study on vendor selection for IBS project is largely neglected. Decision Support System (DSS is proposed for this purpose. Yet, most of the DSS models are impractical since they are complicated and difficult for a layman such as project managers to use. Research indicates that the rapid development of ICT has highly potential towards simple and effective DSS. Thus, this paper highlights the importance and research approach for vendor selection in IBS project management. The study is based on Design Science Research Methodology with combination of case studies. It is anticipates that this study will yield an effective value-for-money decision making platform to manage vendor selection process.
Strain relaxation of germanium-tin (GeSn) fins

Science.gov (United States)

Kang, Yuye; Huang, Yi-Chiau; Lee, Kwang Hong; Bao, Shuyu; Wang, Wei; Lei, Dian; Masudy-Panah, Saeid; Dong, Yuan; Wu, Ying; Xu, Shengqiang; Tan, Chuan Seng; Gong, Xiao; Yeo, Yee-Chia

2018-02-01

Strain relaxation of biaxially strained Ge1-xSnx layer when it is patterned into Ge1-xSnx fin structures is studied. Ge1-xSnx-on-insulator (GeSnOI) substrate was realized using a direct wafer bonding (DWB) technique and Ge1-xSnx fin structures were formed by electron beam lithography (EBL) patterning and dry etching. The strain in the Ge1-xSnx fins having fin widths (WFin) ranging from 1 μm down to 80 nm was characterized using micro-Raman spectroscopy. Raman measurements show that the strain relaxation increases with decreasing WFin. Finite element (FE) simulation shows that the strain component in the transverse direction relaxes with decreasing WFin, while the strain component along the fin direction remains unchanged. For various Ge1-xSnx fin widths, transverse strain relaxation was further extracted using micro-Raman spectroscopy, which is consistent with the simulation results.

Treatment Options by Stage (Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer)

Science.gov (United States)

... diagnosed, tests are done to find out if cancer cells have spread within the ovaries or to other parts of the body. The ... single ovary or fallopian tube. In stage IB, cancer is found inside both ovaries or fallopian tubes. In stage IC, cancer is ...
Binary phase diagrams based on elements VIIIA and IB periods of the D.I. Mendeleev’s table and features of crystallographic parameters

Science.gov (United States)

Potekaev, A. I.; Klopotov, A. A.; Porobova, S. A.; Klopotov, V. D.; Markova, T. N.; Imanaliev, M. I.

2017-01-01

The data obtained as a result of the analysis of crystallogeometric parameters and the structure of state diagrams of binary systems from elements VIIIA and IB periods of the D.I. Mendeleev’s table are presented. It is shown that the classification of the evolution of phase diagrams of binary systems by types, proposed by T.A. Lebedev, correlates with features of concentration dependences of the deviation of atomic volumes in solid solutions from Zen law.
A novel one-step real-time multiplex PCR assay to detect Streptococcus agalactiae presence and serotypes Ia, Ib, and III.

Science.gov (United States)

Furfaro, Lucy L; Chang, Barbara J; Payne, Matthew S

2017-09-01

Streptococcus agalactiae is the leading cause of early-onset neonatal sepsis. Culture-based screening methods lack the sensitivity of molecular assays and do not indicate serotype; a potentially important virulence marker. We aimed to develop a multiplex PCR to detect S. agalactiae while simultaneously identifying serotypes Ia, Ib, and III; commonly associated with infant disease. Primers were designed to target S. agalactiae serotype-specific cps genes and the dltS gene. The assay was validated with 512 vaginal specimens from pregnant women. 112 (21.9%) were dltS positive, with 14.3%, 0.9%, and 6.3% of these identified as cps Ia, Ib, and III, respectively. Our assay is a specific and sensitive method to simultaneously detect S. agalactiae and serotypes Ia, Ib, and III in a single step. It is of high significance for clinical diagnostic applications and also provides epidemiological data on serotype, information that may be important for vaccine development and other targeted non-antibiotic therapies. Copyright © 2017 Elsevier Inc. All rights reserved.
A novel mini-DNA barcoding assay to identify processed fins from internationally protected shark species.

Science.gov (United States)

Fields, Andrew T; Abercrombie, Debra L; Eng, Rowena; Feldheim, Kevin; Chapman, Demian D

2015-01-01

There is a growing need to identify shark products in trade, in part due to the recent listing of five commercially important species on the Appendices of the Convention on International Trade in Endangered Species (CITES; porbeagle, Lamna nasus, oceanic whitetip, Carcharhinus longimanus scalloped hammerhead, Sphyrna lewini, smooth hammerhead, S. zygaena and great hammerhead S. mokarran) in addition to three species listed in the early part of this century (whale, Rhincodon typus, basking, Cetorhinus maximus, and white, Carcharodon carcharias). Shark fins are traded internationally to supply the Asian dried seafood market, in which they are used to make the luxury dish shark fin soup. Shark fins usually enter international trade with their skin still intact and can be identified using morphological characters or standard DNA-barcoding approaches. Once they reach Asia and are traded in this region the skin is removed and they are treated with chemicals that eliminate many key diagnostic characters and degrade their DNA ("processed fins"). Here, we present a validated mini-barcode assay based on partial sequences of the cytochrome oxidase I gene that can reliably identify the processed fins of seven of the eight CITES listed shark species. We also demonstrate that the assay can even frequently identify the species or genus of origin of shark fin soup (31 out of 50 samples).
A novel mini-DNA barcoding assay to identify processed fins from internationally protected shark species.

Directory of Open Access Journals (Sweden)

Andrew T Fields

Full Text Available There is a growing need to identify shark products in trade, in part due to the recent listing of five commercially important species on the Appendices of the Convention on International Trade in Endangered Species (CITES; porbeagle, Lamna nasus, oceanic whitetip, Carcharhinus longimanus scalloped hammerhead, Sphyrna lewini, smooth hammerhead, S. zygaena and great hammerhead S. mokarran in addition to three species listed in the early part of this century (whale, Rhincodon typus, basking, Cetorhinus maximus, and white, Carcharodon carcharias. Shark fins are traded internationally to supply the Asian dried seafood market, in which they are used to make the luxury dish shark fin soup. Shark fins usually enter international trade with their skin still intact and can be identified using morphological characters or standard DNA-barcoding approaches. Once they reach Asia and are traded in this region the skin is removed and they are treated with chemicals that eliminate many key diagnostic characters and degrade their DNA ("processed fins". Here, we present a validated mini-barcode assay based on partial sequences of the cytochrome oxidase I gene that can reliably identify the processed fins of seven of the eight CITES listed shark species. We also demonstrate that the assay can even frequently identify the species or genus of origin of shark fin soup (31 out of 50 samples.
Optimization analysis of convective–radiative longitudinal fins with temperature-dependent properties and different section shapes and materials

International Nuclear Information System (INIS)

Mosayebidorcheh, S.; Hatami, M.; Mosayebidorcheh, T.; Ganji, D.D.

2015-01-01

Graphical abstract: Temperature distribution along the fins obtained for different material and section shapes. - Highlights: • The steady state thermal analysis of longitudinal fins is presented. • The properties of fins are assumed as a function of temperature. • The rectangular, convex, triangular and concave profiles are considered for fin shape. • Least Square Method (LSM) is used for solving the governing equation. • Thermal optimization of fin geometry is presented based on maximum value of heat transfer. - Abstract: The main aim of this study is to obtain an optimum design point for fin geometry, so that heat transfer rate reaches to a maximum value in a constant fin volume. Effect of fin thicknesses ratio (τ), convection coefficient power index (m), profile power parameter (n), base thickness (δ) and fin material are evaluated in the fin optimization point for heat transfer rate, effectiveness and efficiency. It’s assumed that the thickness of longitudinal fins varies with length in a special profile, so four different shapes (rectangular, convex, triangular and concave) are considered. In present study, temperature-dependent heat generation, convection and radiation are considered and an analytical technique based on the least square method is proposed for the solution methodology. Results show that by increasing the fin thicknesses ratio, maximum heat transfer rate decreases and Copper among the other materials has the most heat transfer rate in a constant volume.
QnrS1- and Aac(6’-Ib-cr-producing Escherichia coli among isolates from animals of different sources: susceptibility and genomic characterization

Directory of Open Access Journals (Sweden)

Daniela eJones-Dias

2016-05-01

Full Text Available Salmonella enterica and Escherichia coli can inhabit humans and animals from multiple origins. These bacteria are often associated with gastroenteritis in animals, being a frequent cause of resistant zoonotic infections. In fact, bacteria from animals can be transmitted to humans through the food chain and direct contact. In this study, we aimed to assess the antibiotic susceptibility of a collection of S. enterica and E. coli recovered from animals of different sources, performing a genomic comparison of the plasmid-mediated quinolone resistance (PMQR-producing isolates detected.Antibiotic susceptibility testing revealed a high number of non wild-type isolates for fluoroquinolones among S. enterica recovered from poultry isolates. In turn, the frequency of non-wild-type E. coli to nalidixic acid and ciprofloxacin was higher in food-producing animals than in companion or zoo animals. Globally, we detected two qnrS1 and two aac(6’-Ib-cr in E. coli isolates recovered from animals of different origins. The genomic characterization of QnrS1-producing E. coli showed high genomic similarity (O86:H12 and ST2297, although they have been recovered from a healthy turtle dove from a Zoo Park, and from a dog showing symptoms of infection. The qnrS1 gene was encoded in a IncN plasmid, also carrying blaTEM-1-containing Tn3. Isolates harboring aac(6’-Ib-cr were detected in two captive bottlenose dolphins, within a time span of two years. The additional antibiotic resistance genes of the two aac(6’-Ib-cr-positive isolates (blaOXA-1, blaTEM-1, blaCTX-M-15, catB3, aac(3-IIa and tetA were enclosed in IncFIA plasmids that differed in a single transposase and 60 single nucleotide variants. The isolates could be assigned to the same genetic sublineage – ST131 fimH30-Rx (O25:H4, confirming clonal spread. PMQR-producing isolates were associated with symptomatic and asymptomatic hosts, which highlight the aptitude of E. coli to act as silent vehicles, allowing
Experimental Study on Cooling Heat Transfer of Supercritical Carbon Dioxide Inside Horizontal Micro-Fin Tubes

Science.gov (United States)

Kuwahara, Ken; Higashiiu, Shinya; Ito, Daisuke; Koyama, Shigeru

This paper deals with the experimental study on cooling heat transfer of supercritical carbon dioxide inside micro-fin tubes. The geometrical parameters in micro-fin tubes used in the present study are 6.02 mm in outer diameter, 4.76 mm to 5.11 mm in average inner diameter, 0.15 mm to 0.24 mm in fin height, 5 to 25 in helix angle, 46 to 52 in number of fins and 1.4 to 2.3 in area expansion ratio. Heat transfer coefficients were measured at 8-10 MPa in pressure, 360-690 kg/(m2•s) in mass velocity and 20-75 °C in CO2 temperature. The measured heat transfer coefficients of micro-fin tubes were 1.4 to 2 times higher than those of the smooth tube having 4.42 in inner diameter. The predicted heat transfer coefficients using the correlation equation, which was developed for single-phase turbulent fluid flow inside micro-fin-tubes, showed large deviations to the measured values. The new correlation to predict cooling heat transfer coefficient of supercritical carbon dioxide inside micro-fin tubes was developed taking into account the shape of fins based on experimental data empirically. This correlation equation agreed within ±20% of almost all of the experimental data.
An IPMC-enabled bio-inspired bending/twisting fin for underwater applications

International Nuclear Information System (INIS)

Palmre, Viljar; Pugal, David; Kim, Sungjun; Kim, Kwang J; Hubbard, Joel J; Fleming, Maxwell; Leang, Kam K

2013-01-01

This paper discusses the design, fabrication, and characterization of an ionic polymer–metal composite (IPMC) actuator-based bio-inspired active fin capable of bending and twisting motion. It is pointed out that IPMC strip actuators are used in the simple cantilever configuration to create simple bending (flapping-like) motion for propulsion in underwater autonomous systems. However, the resulting motion is a simple 1D bending and performance is rather limited. To enable more complex deformation, such as the flapping (pitch and heaving) motion of real pectoral and caudal fish fins, a new approach which involves molding or integrating IPMC actuators into a soft boot material to create an active control surface (called a ‘fin’) is presented. The fin can be used to realize complex deformation depending on the orientation and placement of the actuators. In contrast to previously created IPMCs with patterned electrodes for the same purpose, the proposed design avoids (1) the more expensive process of electroless plating platinum all throughout the surface of the actuator and (2) the need for specially patterning the electrodes. Therefore, standard shaped IPMC actuators such as those with rectangular dimensions with varying thicknesses can be used. One unique advantage of the proposed structural design is that custom shaped fins and control surfaces can be easily created without special materials processing. The molding process is cost effective and does not require functionalizing or ‘activating’ the boot material similar to creating IPMCs. For a prototype fin (90 mm wide × 60 mm long × 1.5 mm thick), the measured maximum tip displacement was approximately 44 mm and the twist angle of the fin exceeded 10°. Lift and drag measurements in water where the prototype fin with an airfoil profile was dragged through water at a velocity of 21 cm s −1 showed that the lift and drag forces can be affected by controlling the IPMCs embedded into the fin structure
Trastuzumab Emtansine in Treating Older Patients With Human Epidermal Growth Factor Receptor 2-Positive Stage I-III Breast Cancer

Science.gov (United States)

2018-02-01

Estrogen Receptor Status; HER2 Positive Breast Carcinoma; Progesterone Receptor Status; Stage I Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage III Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Steady-state and transient heat transfer through fins of complex geometry

Directory of Open Access Journals (Sweden)

Taler Dawid

2014-06-01

Full Text Available Various methods for steady-state and transient analysis of temperature distribution and efficiency of continuous-plate fins are presented. For a constant heat transfer coefficient over the fin surface, the plate fin can be divided into imaginary rectangular or hexangular fins. At first approximate methods for determining the steady-state fin efficiency like the method of equivalent circular fin and the sector method are discussed. When the fin geometry is complex, thus transient temperature distribution and fin efficiency can be determined using numerical methods. A numerical method for transient analysis of fins with complex geometry is developed. Transient temperature distributions in continuous fins attached to oval tubes is computed using the finite volume - finite element methods. The developed method can be used in the transient analysis of compact heat exchangers to calculate correctly the heat flow rate transferred from the finned tubes to the fluid.
Extended Cancer Education for Longer-Term Survivors in Primary Care for Patients With Stage I-II Breast or Prostate Cancer or Stage I-III Colorectal Cancer

Science.gov (United States)

2017-11-15

Stage I Breast Cancer; Stage I Colorectal Cancer AJCC v6 and v7; Stage I Prostate Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage II Colorectal Cancer AJCC v7; Stage II Prostate Cancer; Stage IIA Breast Cancer; Stage IIA Colorectal Cancer AJCC v7; Stage IIA Prostate Cancer; Stage IIB Breast Cancer; Stage IIB Colorectal Cancer AJCC v7; Stage IIB Prostate Cancer; Stage IIC Colorectal Cancer AJCC v7; Stage III Colorectal Cancer AJCC v7; Stage IIIA Colorectal Cancer AJCC v7; Stage IIIB Colorectal Cancer AJCC v7; Stage IIIC Colorectal Cancer AJCC v7
Key factors of successful JIT integration with IBS - An overview

Science.gov (United States)

Asri, Mohammad Azwanie Naim Mohammad; Nawi, Mohd Nasrun Mohd; Nadarajan, Santhirasegaran

2016-08-01

The Just-In-Time (JIT) philosophy has been used for many decades to increase productivity through waste elimination process. The purpose of this paper is to contribute to the knowledge by addressing the transportation and material delivery activities in Industrialized Building System (IBS) and integrating JIT to improve the performance of those activities. The literature review has been conducted through relevant database. It was found that there is a need for more holistic approach to be adopted to integrate JIT in IBS project. This paper discusses the key success factors for effective integration between JIT and IBS in the context of transportation and material delivery activities.
FRAGMENTATION ISSUE IN MALAYSIAN INDUSTRIALISED BUILDING SYSTEM (IBS PROJECTS

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MOHD NASRUN MOHD NAWI

2014-02-01

Full Text Available As a developing country, Malaysian is currently driving for implementing a new or modern construction method, the Industrialised Building System (IBS, as an alternative towards enhancing construction performance. Currently, most of the IBS project developments in Malaysia are still conducted by using the traditional construction process approach. This traditional construction process has been widely criticised for its fragmented approach to project delivery and its failure to form effective teams thus created a number of issues such as reworks, time delay, rising costs, lack of communication and coordination, and wastages. This paper through literature review aims to highlight this fragmentation issue and clarify how far it affects the process of IBS implementation. Suggestions on how an integrated approach in design and construction in order to minimise the fragmentation gaps will be concluded.
Plate-fin array cooling using a finger-like piezoelectric fan

International Nuclear Information System (INIS)

Shyu, Jin-Cherng; Syu, Jhih-Zong

2014-01-01

In this study, the heat transfer of a plate-fin array cooled by a vibrating finger-like piezoelectric fan comprising four flexible rectangular blades was investigated. The results indicated that the heat transfer enhancement of the fin array cooled by a vibrating piezoelectric fan at x/L = 0.5 and H = 5 mm ranged between 1.5 and 3.3, regardless of the fin array orientation. However, the heat transfer enhancement caused by a fan being placed at either edge of the fin array yielded a dissimilar result between both of the fin array orientations because of the superimposed effects of the boundary layer development and the air flow induced by the fan. This dissimilarity was especially noticeable when the piezoelectric fan was composed of aluminum blades to accommodate the moderate Reynolds number. In addition to the Reynolds number, the ratio of the fan blade vibration envelope to the source area determined the Nu number of the piezoelectric fan-cooled fin array. This design enhanced the fin array heat transfer and reduced cooler volume by embedding multiple vibrating beams into the fin array. -- Highlights: • Heat transfer of a piezoelectric fan-cooled plate-fin array was investigated. • Effects of fan position, fan height and fan material on heat transfer were examined. • Similar heat transfer enhancement range was shown for both fin array orientations. • Fin heat transfer with a running Al fan at x = 0 was higher than that at x = 0.25L. • Besides fan Reynolds number, the area ratio also determined Nu of the fin array
The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast Cancer

Science.gov (United States)

2018-03-02

Invasive Breast Carcinoma; Stage I Breast Cancer AJCC v7; Stage IA Breast Cancer AJCC v7; Stage IB Breast Cancer AJCC v7; Stage II Breast Cancer AJCC v6 and v7; Stage IIA Breast Cancer AJCC v6 and v7; Stage IIB Breast Cancer AJCC v6 and v7
Batoid locomotion: effects of speed on pectoral fin deformation in the little skate, Leucoraja erinacea.

Science.gov (United States)

Di Santo, Valentina; Blevins, Erin L; Lauder, George V

2017-02-15

Most batoids have a unique swimming mode in which thrust is generated by either oscillating or undulating expanded pectoral fins that form a disc. Only one previous study of the freshwater stingray has quantified three-dimensional motions of the wing, and no comparable data are available for marine batoid species that may differ considerably in their mode of locomotion. Here, we investigate three-dimensional kinematics of the pectoral wing of the little skate, Leucoraja erinacea , swimming steadily at two speeds [1 and 2 body lengths (BL) s -1 ]. We measured the motion of nine points in three dimensions during wing oscillation and determined that there are significant differences in movement amplitude among wing locations, as well as significant differences as speed increases in body angle, wing beat frequency and speed of the traveling wave on the wing. In addition, we analyzed differences in wing curvature with swimming speed. At 1 BL s -1 , the pectoral wing is convex in shape during the downstroke along the medio-lateral fin midline, but at 2 BL s -1 the pectoral fin at this location cups into the flow, indicating active curvature control and fin stiffening. Wing kinematics of the little skate differed considerably from previous work on the freshwater stingray, which does not show active cupping of the whole fin on the downstroke. © 2017. Published by The Company of Biologists Ltd.
El Cortijo del Ahorcado (Baeza, Jaén : estudio de los restos arquitectónicos de época ibérica

Directory of Open Access Journals (Sweden)

María del Rosario Lucas Pellicer

1988-01-01

Full Text Available Las investigaciones dedicadas en los últimos años a la arqueología del mundo ibérico han contribuido notablemente a ampliar los conocimientos sobre la arquitectura funeraria y sobre los relieves y esculturas vinculados a excepcionales monumentos erigidos en honor a los difuntos. La publicación de M. Almagro Gorbea Arquitectura y Sociedad en la Cultura Ibérica, aparecida en 1983, es, junto con otros trabajos más recientes, buena prueba de los logros alcanzados. Basta contrastar las actuales teorías y la documentación hoy disponible con la síntesis que sobre arte ibérico trazara García y Bellido en 1953, para hacernos una idea cabal del progreso alcanzado en los últimos años.
A unique set of SH3-SH3 interactions controls IB1 homodimerization

DEFF Research Database (Denmark)

Kristensen, Ole; Guenat, Sylvie; Dar, Imran

2006-01-01

Islet-brain 1 (IB1 or JIP-1) is a scaffold protein that interacts with components of the c-Jun N-terminal kinase (JNK) signal-transduction pathway. IB1 is expressed at high levels in neurons and in pancreatic beta-cells, where it controls expression of several insulin-secretory components...... reduces IB1-dependent basal JNK activity in 293T cells. Impaired dimerization also results in a reduction in glucose transporter type 2 expression and in glucose-dependent insulin secretion in pancreatic beta-cells. Taken together, these results indicate that IB1 homodimerization through its SH3 domain...
A note on the heat transfer in convective fins

International Nuclear Information System (INIS)

Razelos, P.

1979-01-01

In this paper a generalized approach to the problem of heat transfer through convective fins is given. The proper dimensionless variables, which specify the general problem are identified, and upper bounds of the values of the dimensionless number Nsub(r) defined as 'the ratio of the heat transferred by the fin to that of the corresponding bare surface' are derived. It was shown that these limiting values of the Nsub(r) are 1/√B 1 and √2/B 1 for longitudinal fins and spines respectively, where B 1 is the Biot number hb/k, while for annular fins of constant thickness and hyperbolic profile, Nsub(r) 1 , where K(β) is a number determined by the profile of the fin and the ratio β = x 2 /x 1 of the outside to the inside radii. It was also shown that for longitudinal fins and spinces the possible adverse insulating effect by the use of the fin is avoided, if one selects the value of √hA/kC [de

A comparative analysis on the shed vortices from the wake of finned, foam-wrapped cylinders

Energy Technology Data Exchange (ETDEWEB)

Khashehchi, Morteza [Department of Agro-Technology, College of Aburaihan, University of Tehran, Tehran (Iran, Islamic Republic of); Ashtiani Abdi, Iman; Hooman, Kamel, E-mail: m.khashehchi@ut.ac.ir [School of Mechanical and mining Engineering, University of Queensland, Brisbane (Australia)

2017-08-15

The wake characteristics behind a finned and a foam-wrapped circular cylinder has been compared in a study (Khashehchi et al 2014 Exp. Therm. Fluid Sci. 52 328–38) done by the Authors. In this paper, the shed vortices from the wake of the same cylinders have been studied. Shedding in a bluff body has an important effect on increasing the pressure drop downstream of the object. Here, we have used particle image velocimetry to investigate the detached vortices from the wake behind a foam-wrapped and a finned cylinder. The standard case of cross-flow over a bare cylinder, i.e. no surface extension, has also been tested as a benchmark. The experiments have been performed for Reynolds numbers 2000 based on the mean air velocity and the cylinder’s outer diameter. To identify the features of each aforementioned case, linear stochastic estimation has been applied to the velocity fields. Results show that unlike the fin, adding foam to the cylinder surface increases the size of detached vortices and amplifies the core strength. Moreover, foam-wrapped cylinder in contrast to the finned one produces strong three-dimensionality. Interestingly, finned cylinder’s results show less three-dimensionality compared to the bare cylinder. (paper)
Using "Competing Visions of Human Rights" in an International IB World School

Science.gov (United States)

Tolley, William J.

2013-01-01

William Tolley, a teaching fellow with the Choices Program, is the Learning and Innovation Coach and head of history at the International School of Curitiba, Brazil (IB). He writes in this article that he has found that the "Competing Visions of Human Rights" teaching unit, developed by Brown University's Choices Program, provides a…
Three-dimensional transient cooling simulations of a portable electronic device using PCM (phase change materials) in multi-fin heat sink

International Nuclear Information System (INIS)

Wang, Yi-Hsien; Yang, Yue-Tzu

2011-01-01

Transient three-dimensional heat transfer numerical simulations were conducted to investigate a hybrid PCM (phase change materials) based multi-fin heat sink. Numerical computation was conducted with different amounts of fins (0 fin, 3 fins and 6 fins), various heating power level (2 W, 3 W and 4 W), different orientation tests (vertical/horizontal/slanted), and charge and discharge modes. Calculating time step (0.03 s, 0.05 s, and 0.07 s) size was discussed for transient accuracy as well. The theoretical model developed is validated by comparing numerical predictions with the available experimental data in the literature. The results showed that the transient surface temperatures are predicted with a maximum discrepancy within 10.2%. The operation temperature can be controlled well by the attendance of phase change material and the longer melting time can be conducted by using a multi-fin hybrid heat sink respectively. -- Highlights: → Electronic device cooling use phase change materials. → N-eicosane is adapted as phase change materials. → Present surface transient temperatures prediction error is within 10.2%. → Hybrid PCM-heat sink system provides stable operation temperature. → Orientation effects show independent on the phase change performance.
Criteria for analysis and optimization of longitudinal fins with convective tip

International Nuclear Information System (INIS)

Gomes, E.S.

1983-01-01

The problem of heat transfer in longitudinal fins with the main geometries used in equipaments of heat transfer by convection is analyzed. The equation of energy is solved analytically of several geometries fins, with unidimensional formulation, through the use of the convective heat transfer coefficient. The problem of fin optimization is approached analytically yielding the parameters which allow the maximum heat transfer for each particular material waste in the fin. The use of the insulated tip model suggests the use of fins and its optimization for any Biot number of the fin. The use of the convective tip model allows us to determine when is vantageous or disadvantageous to use fins and when fin optimization is possible according to the value of the Biot number and to a convection parameter on the fin tip. (Author) [pt
Nerve growth factor and diarrhea-predominant irritable bowel syndrome (IBS-D): a potential therapeutic target?

Science.gov (United States)

Xu, Xiao-juan; Liu, Liang; Yao, Shu-kun

2016-01-01

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by recurrent abdominal pain or discomfort associated with abnormal bowel habits. Diarrhea-predominant IBS (IBS-D) is a major subtype of IBS, the predominant manifestations of which are abdominal pain and diarrhea. The pathogenesis of IBS-D remained unknown until recently. The effects of psychosocial stress, central hypervigilance, neuroendocrine abnormality, disturbed gastrointestinal motility, mucosal immune activation, intestinal barrier dysfunction, visceral hypersensitivity (VH), altered gut flora, and genetic susceptibility may be involved in its development. Recently, increased attention has been placed on the neural-immune-endocrine network mechanism in IBS-D, especially the role of various neuroendocrine mediators. As a member of the neurotrophin family, nerve growth factor (NGF) has diverse biological effects, and participates in the pathogenesis of many diseases. Basic studies have demonstrated that NGF is associated with inflammatory- and stress-related VH, as well as stress-related intestinal barrier dysfunction. The aim of this study is to summarize recent literature and discuss the role of NGF in the pathophysiology of IBS-D, especially in VH and intestinal barrier dysfunction, as well as its potential as a therapeutic target in IBS-D.
Stage-specific mortality of Baltic cod ( Gadus morhua L.) eggs

DEFF Research Database (Denmark)

Wieland, Kai; Hinrichsen, H.H.; Grønkjær, P.

2000-01-01

A study on cod egg mortality was carried out in the Bornholm Basin (southern central Baltic Sea) toward the end of July 1996. An initial egg aggregation marked by a satellite-tracked drifter buoy was sampled repeatedly over an Ii-day period; profiles of temperature, salinity and dissolved oxygen...... were concurrently recorded. Three replicate estimates of mortality were obtained for each pair of subsequent developmental stages from newly spawned eggs to early larvae. A consistent pattern of stage-specific mortality coincided well with previous experimental observations. Average daily mortality...... rates were 7.2% (eggs IA/IB), 38.7% (eggs (IB/II), 25.6% (eggs II/III), 40.0% (eggs III/IV), and 42.3% (eggs IV/early larvae). The cumulative mortality until hatch amounted to 99.9%. Results from hydrodynamic modelling, however, indicated that the drifter's trajectory was influenced by wind stress...
Actuation of a robotic fish caudal fin for low reaction torque

Science.gov (United States)

Yun, Dongwon; Kim, Kyung-Soo; Kim, Soohyun; Kyung, Jinho; Lee, Sunghee

2011-07-01

In this paper, a novel caudal fin for actuating a robotic fish is presented. The proposed caudal fin waves in a vertical direction with a specific spatial shape, which is determined by a so-called shape factor. For a specific shape factor, a traveling wave with a vertical phase difference is formed on a caudal fin during fin motion. It will be shown by the analysis that the maximum reaction torque at the joint of a caudal fin varies depending on the shape factors. Compared with a conventional plate type caudal fin, the proposed fin with a shape factor of 2π can eliminate the reaction torque perfectly, while keeping the propulsion force unchanged. The benefits of the proposed fin will be demonstrated by experiments.
Nonsense mutation in the glycoprotein Ibα coding sequence associated with Bernard-Soulier syndrome

International Nuclear Information System (INIS)

Ware, J.; Russell, S.R.; Vicente, V.; Scharf, R.E.; Tomer, A.; McMillian, R.; Ruggeri, Z.M.

1990-01-01

Three distinct gene products, the α and β chains of glycoprotein (GP) Ib and GP IX, constitute the platelet membrane GP Ib-IX complex, a receptor for von Willebrand factor and thrombin involved in platelet adhesion and aggregation. Defective function of the GP Ib-IX complex is the hallmark of a rare congenital bleeding disorder of still undefined pathogenesis, the Bernard-Soulier syndrome. The authors have analyzed the molecular basis of the disease in one patient in whom immunoblotting of solubilized platelets demonstrated absence of normal GP Ibα but presence of a smaller immunoreactive species. The truncated polypeptide was also present, along with normal protein, in platelets from the patient's mother and two of his four children. Genetic characterization identified a nucleotide transition changing the Trp-343 codon (TGG) to a nonsense codon (TGA). Such a mutation explains the origin of the smaller GP Ibα, which by lacking half of the sequence on the carboxyl-terminal side, including the transmembrane domain, cannot be properly inserted in the platelet membrane. Both normal and mutant codons were found in the patient, suggesting that he is a compound heterozygote with a still unidentified defect in the other GP Ibα allele. Nonsense mutation and truncated GP Ibα polypeptide were found to cosegregate in four individuals through three generations and were associated with either Bernard-Soulier syndrome or carrier state phenotype. The molecular abnormality demonstrated in this family provides evidence that defective synthesis of GP Ibα alters the membrane expression of the GP Ib-IX complex and may be responsible for Bernard-Soulier syndrome
IB Offering Certificate for Careers

Science.gov (United States)

Robelen, Erik W.

2012-01-01

The International Baccalaureate (IB) organization, best known in the United States for its prestigious two-year diploma program for juniors and seniors, will enter new terrain this fall as it formally rolls out an initiative centered on a variety of career pathways that includes engineering, culinary arts, and automotive technology. The move comes…
3D modeling of dual-gate FinFET.

Science.gov (United States)

Mil'shtein, Samson; Devarakonda, Lalitha; Zanchi, Brian; Palma, John

2012-11-13

The tendency to have better control of the flow of electrons in a channel of field-effect transistors (FETs) did lead to the design of two gates in junction field-effect transistors, field plates in a variety of metal semiconductor field-effect transistors and high electron mobility transistors, and finally a gate wrapping around three sides of a narrow fin-shaped channel in a FinFET. With the enhanced control, performance trends of all FETs are still challenged by carrier mobility dependence on the strengths of the electrical field along the channel. However, in cases when the ratio of FinFET volume to its surface dramatically decreases, one should carefully consider the surface boundary conditions of the device. Moreover, the inherent non-planar nature of a FinFET demands 3D modeling for accurate analysis of the device performance. Using the Silvaco modeling tool with quantization effects, we modeled a physical FinFET described in the work of Hisamoto et al. (IEEE Tran. Elec. Devices 47:12, 2000) in 3D. We compared it with a 2D model of the same device. We demonstrated that 3D modeling produces more accurate results. As 3D modeling results came close to experimental measurements, we made the next step of the study by designing a dual-gate FinFET biased at Vg1 >Vg2. It is shown that the dual-gate FinFET carries higher transconductance than the single-gate device.
The use of pelvic fins for benthic locomotion during foraging behavior in Potamotrygon motoro (Chondrichthyes: Potamotrygonidae

Directory of Open Access Journals (Sweden)

Akemi Shibuya

2015-06-01

Full Text Available Synchronized bipedal movements of the pelvic fins provide propulsion (punting during displacement on the substrate in batoids with benthic locomotion. In skates (Rajidae this mechanism is mainly generated by the crural cartilages. Although lacking these anatomical structures, some stingray species show modifications of their pelvic fins to aid in benthic locomotion. This study describes the use of the pelvic fins for locomotory performance and body re-orientation in the freshwater stingray Potamotrygon motoro (Müller & Henle, 1841 during foraging. Pelvic fin movements of juvenile individuals of P. motoro were recorded in ventral view by a high-speed camera at 250-500 fields/s-1. Potamotrygon motoro presented synchronous, alternating and unilateral movements of the pelvic fins, similar to those reported in skates. Synchronous movements were employed during straightforward motion for pushing the body off the substrate as well as for strike feeding, whereas unilateral movements were used to maneuver the body to the right or left during both locomotion and prey capture. Alternating movements of the pelvic fins are similar to bipedal movements in terrestrial and semi-aquatic tetrapods. The pelvic fins showed coordinated movements during feeding even when stationary, indicating that they have an important function in maintaining body posture (station holding during prey capture and manipulation. The use of pelvic fins during prey stalking may be advantageous because it results in less substrate disturbance when compared to movements generated by pectoral fin undulation. The range of pelvic fin movements indicates more complex control and coordination of the pelvic radial muscles.
Energy analysis and improvement potential of finned double-pass solar collector

International Nuclear Information System (INIS)

Fudholi, Ahmad; Sopian, Kamaruzzaman; Othman, Mohd Yusof; Ruslan, Mohd Hafidz; Bakhtyar, B.

2013-01-01

Highlights: • The developed steady state model predicting the thermal performance of double-pass solar collectors is presented. • The main objective of this paper is to analyze the energy and exergy of finned double-pass solar collector. • A new mathematical model, solution procedure, and test results are presented. • The thermal performances and improvement potential of the double-pass solar collectors are discussed. - Abstract: Steady state energy balance equations for the finned double-pass solar collector have been developed. These equations were solved using the matrix inversion method. The predicted results were in agreement with the results obtained from the experiments. The predictions and experiments were observed at the mass flow rate ranging between 0.03 kg/s and 0.1 kg/s, and solar radiation ranging between 400 W/m 2 and 800 W/m 2 . The effects of mass flow rates and solar radiation levels on energy efficiency, exergy efficiency and the improvement potential have been observed. The optimum energy efficiency is approximately 77%, which was observed at the mass flow rate of 0.09 kg/s. The optical efficiency of the finned double-pass solar collector is approximately 70–80%. The exergy efficiency is approximately 15–28% and improvement potential of 740–1070 W for a solar radiation of 425–790 W/m 2
Constructal design of finned tubes used in air-cooled heat exchangers

Energy Technology Data Exchange (ETDEWEB)

Shokouhmand, Hossein; Mahjoub, Shoeib [University of Tehran, Tehran (Iran, Islamic Republic of); Salimpour, Mohammad Reza [Isfahan University of Technology, Isfahan (Iran, Islamic Republic of)

2014-06-15

The present study documents the constructal design and optimization of finned tubes used in air-cooled heat exchangers. The considered tubes are equipped with annular fins. The aim is to minimize the overall thermal resistance by morphing the geometry. The geometrical and thermo-physical parameters considered are the number of fins, ratio of fin height to tube diameter, Stanton number, ratio of fin conductivity to air conductivity, ratio of in-tube fluid conductivity to air conductivity and dimensionless pressure drop. Two constraints are applied in the optimization process: fixed overall volume of heat exchanger and fixed volume fraction of fin material. It is found that there exist optimal values for the number and the height of fins. Moreover, the optimal heat transfer has an extremum in a special volume fraction of fin material.
Constructal design of finned tubes used in air-cooled heat exchangers

International Nuclear Information System (INIS)

Shokouhmand, Hossein; Mahjoub, Shoeib; Salimpour, Mohammad Reza

2014-01-01

The present study documents the constructal design and optimization of finned tubes used in air-cooled heat exchangers. The considered tubes are equipped with annular fins. The aim is to minimize the overall thermal resistance by morphing the geometry. The geometrical and thermo-physical parameters considered are the number of fins, ratio of fin height to tube diameter, Stanton number, ratio of fin conductivity to air conductivity, ratio of in-tube fluid conductivity to air conductivity and dimensionless pressure drop. Two constraints are applied in the optimization process: fixed overall volume of heat exchanger and fixed volume fraction of fin material. It is found that there exist optimal values for the number and the height of fins. Moreover, the optimal heat transfer has an extremum in a special volume fraction of fin material.
Computational thermal analysis of cylindrical fin design parameters and a new methodology for defining fin structure in LED automobile headlamp cooling applications

International Nuclear Information System (INIS)

Sökmen, Kemal Furkan; Yürüklü, Emrah; Yamankaradeniz, Nurettin

2016-01-01

Highlights: • In the study, cooling of LED headlamps in automotive is investigated. • The study is based on free convection cooling of LED module. • Besides free convection, Monte Carlo model is used as radiation model as well. • A new algorithm is presented for designing optimum fin structure. • Suggested algorithm for optimum design is verified by various simulations. - Abstract: In this study, the effects of fin design, fin material, and free and forced convection on junction temperature in automotive headlamp cooling applications of LED lights are researched by using ANSYS CFX 14 software. Furthermore a new methodology is presented for defining the optimum cylindrical fin structure within the given limits. For measuring the performance of methodology, analyses are carried out for various ambient temperatures (25 °C, 50 °C and 80 °C) and different LED power dissipations (0.5 W, 0.75 W, 1 W and 1.25 W). Then, analyses are repeated at different heat transfer coefficients and different fin materials in order to calculate LED junction temperature in order to see if the fin structure proposed by the methodology is appropriate for staying below the given safety temperature limit. As a result, the suggested method has always proposed proper fin structures with optimum characteristics for given LED designs. As another result, for safe junction temperature ranges, it is seen that for all LED power dissipations, adding aluminum or copper plate behind the printed circuit board at low ambient temperatures is sufficient. Also, as the ambient temperature increases, especially in high powered LED lights, addition of aluminum is not sufficient and fin usage becomes essential. High heat transfer coefficient and using copper fin affect the junction temperature positively.
Heat transfer enhancement for fin-tube heat exchanger using vortex generators

International Nuclear Information System (INIS)

Yoo, Seong Yeon; Park, Dong Seong; Chung, Min Ho; Lee, Sang Yun

2002-01-01

Vortex generators are fabricated on the fin surface of a fin-tube heat exchanger to augment the convective heat transfer. In addition to horseshoe vortices formed naturally around the tube of the fin-tube heat exchanger, longitudinal vortices are artificially created on the fin surface by vortex generators. The purpose of this study is to investigate the local heat transfer phenomena in the fin-tube heat exchangers with and without vortex generators, and to evaluate the effect of vortices on the heat transfer enhancement. Naphthalene sublimation technique is employed to measure local mass transfer coefficients, then analogy equation between heat and mass transfer is used to calculate heat transfer coefficients. Experiments are performed for the model of fin-circular tube heat exchangers with and without vortex generators, and of fin-flat tube heat exchangers with and without vortex generators. Average heat transfer coefficients of fin-flat tube heat exchanger without vortex generator are much lower than those of fin-circular tube heat exchanger. On the other hand, fin-flat tube heat exchanger with vortex generators has much higher heat transfer value than conventional fin-circular tube heat exchanger. At the same time, pressure losses for four types of heat exchanger is measured and compared
Numerical study of an innovative design of a finned double-pipe heat exchanger with variable fin-tip thickness

International Nuclear Information System (INIS)

Syed, K.S.; Ishaq, Muhammad; Iqbal, Zafar; Hassan, Ahmad

2015-01-01

Highlights: • Variable fin tip angle significantly effect the velocity and temperature distribution. • Significant gain in the thermal performance with decrease in the friction factor. • Variable fin tip angle must be considered an important parameter in designing finned annulus. - Abstract: The analysis of fully developed laminar convective heat transfer in an innovate design of a finned double-pipe heat exchanger (DPHE) with longitudinal fins of variable thickness of the tip subjected to the constant heat transfer rate boundary conditions is investigated here. The tip thickness is controlled by the ratio of tip to base angles as a parameter whose values varying from 0 to 1 correspond to the fin shapes varying from the triangular to the rectangular cross-section. Upto the knowledge of the authors, this parameter is being introduced for the first time in the literature. Discontinuous Galerkin finite element method (DG-FEM) has been employed in the present work. The overall performance of the proposed DPHE has been investigated by considering the friction factor, the Nusselt number and the j-factor. Upto 178% gain in the Nusselt number and 89% gain in the j-factor have been achieved relative to the rectangular cross-section. Such gains relative to the triangular cross-section are respectively 9.5% and 19%. The results indicate that the newly introduced parameter the ratio of tip to base angles has proved to play significant role in the design of a double-pipe heat exchanger in reducing the cost, weight and frictional loss, in improving the heat transfer rate and making the exchanger energy-efficient. Therefore, it must be considered as an important design parameter for heat exchanger design
High performance flexible CMOS SOI FinFETs

KAUST Repository

Fahad, Hossain M.; Sevilla, Galo T.; Ghoneim, Mohamed T.; Hussain, Muhammad Mustafa

2014-01-01

We demonstrate the first ever CMOS compatible soft etch back based high performance flexible CMOS SOI FinFETs. The move from planar to non-planar FinFETs has enabled continued scaling down to the 14 nm technology node. This has been possible due
香港金融科技的未来%La future de FinTech à Hong Kong

Institute of Scientific and Technical Information of China (English)

香港金融发展局; 杨鑫

2017-01-01

FinTech - l'innovation financiére grace à la technologie - a le potentiel d'apporter des améliorations substantielles de la productivité et de la qualité des services financiers à Hong Kong. Hong Kong, avec son grand secteur financier, est en mesure de gagner de la tendance FinTech et de perdre à d'autres centres si cela ne fonctionne pas. Ce rapport propose une stratégie FinTech comprenant cinq programmes FinTech - Cyber sécurité, paiement et réglement de titre un identifiant numérique et KYC, WealthTech, InsurTech et RegTech - pris en charge par un bureau FinTech par lequel le territoire peut être avancé de maniére décisive.
Ice nucleating particles measured during the laboratory and field intercomparisons FIN-2 and FIN-3 by the diffusion chamber FRIDGE

Science.gov (United States)

Weber, Daniel; Schrod, Jann; Curtius, Joachim; Haunold, Werner; Thomson, Erik; Bingemer, Heinz

2016-04-01

The measurement of atmospheric ice nucleating particles (INP) is still challenging. In the absence of easily applicable INP standards the intercomparison of different methods during collaborative laboratory and field workshops is a valuable tool that can shine light on the performance of individual methods for the measurement of INP [1]. FIN-2 was conducted in March 2015 at the AIDA facility in Karlsruhe as an intercomparison of mobile instruments for measuring INP [2]. FIN-3 was a field campaign at the Desert Research Institutes Storm Peak Laboratory in Colorado in September 2015 [3]. The FRankfurt Ice nucleation Deposition freezinG Experiment (FRIDGE) participated in both experiments. FRIDGE measures ice nucleating particles by electrostatic precipitation of aerosol particles onto Si-wafers in a collection unit, followed by activation, growth, and optical detection of ice crystals on the substrate in an isostatic diffusion chamber [4,5]. We will present and discuss results of our measurements of deposition/condensation INP and of immersion INP with FRIDGE during FIN-2 and FIN-3. Acknowledgements: The valuable contributions of the FIN organizers and their institutions, and of the FIN Workshop Science team are gratefully acknowledged. Our work was supported by Deutsche Forschungsgemeinschaft (DFG) under the Research Unit FOR 1525 (INUIT) and the EU FP7-ENV- 2013 BACCHUS project under Grant Agreement 603445.

Numerical simulation of heat exchangers elliptical tubes and corrugated fins

International Nuclear Information System (INIS)

Borrajo Pérez, Rubén; González Bayón, Juan José; Menéndez Pérez, Alberto

2015-01-01

The intensified heat exchangers fins are widely used in the automotive and domestic industry. The low heat transfer coefficients on the air side are the main reason why these fins of heat exchangers need to be intensified. In this paper, the numerical simulation of a wavy fin type is made with elliptical tubes. The dimensions of the fin is in the range of those used in air conditioning equipment. The friction factor and the mass transfer coefficient as a function of the Reynolds number for this type of fin, always within the laminar regime is determined. The numerical model against experimental results published in the literature is validated. In addition the mechanisms that produce intensified heat transfer fin in such occur. (full text)
Understanding Fish Linear Acceleration Using an Undulatory Biorobotic Model with Soft Fluidic Elastomer Actuated Morphing Median Fins.

Science.gov (United States)

Wen, Li; Ren, Ziyu; Di Santo, Valentina; Hu, Kainan; Yuan, Tao; Wang, Tianmiao; Lauder, George V

2018-04-10

Although linear accelerations are an important common component of the diversity of fish locomotor behaviors, acceleration is one of the least-understood aspects of propulsion. Analysis of acceleration behavior in fishes with both spiny and soft-rayed median fins demonstrates that fin area is actively modulated when fish accelerate. We implemented an undulatory biomimetic robotic fish model with median fins manufactured using multimaterial three-dimensional printing-a spiny-rayed dorsal fin, soft-rayed dorsal/anal fins, and a caudal fin-whose stiffnesses span three orders of magnitude. We used an array of fluidic elastomeric soft actuators to mimic the dorsal/anal inclinator and erector/depressor muscles of fish, which allowed the soft fins to be erected or folded within 0.3 s. We experimentally show that the biomimetic soft dorsal/anal fin can withstand external loading. We found that erecting the soft dorsal/anal fins significantly enhanced the linear acceleration rate, up to 32.5% over the folded fin state. Surprisingly, even though the projected area of the body (in the lateral plane) increased 16.9% when the median fins were erected, the magnitude of the side force oscillation decreased by 24.8%, which may have led to significantly less side-to-side sway in the robotic swimmer. Visualization of fluid flow in the wake of median fins reveals that during linear acceleration, the soft dorsal fin generates a wake flow opposite in direction to that of the caudal fin, which creates propulsive jets with time-variant circulations and jet angles. Erectable/foldable fins provide a new design space for bioinspired underwater robots with structures that morph to adapt to different locomotor behaviors. This biorobotic fish model is also a potentially promising system for studying the dynamics of complex multifin fish swimming behaviors, including linear acceleration, steady swimming, and burst and coast, which are difficult to analyze in freely swimming fishes.
Haute prévalence du Burnout dans les unités Tunisiennes prenant en charge des patients en fin de vie

Science.gov (United States)

Amamou, Badii; Bannour, Ahmed Souhaiel; Ben Hadj Yahia, Meriem; Ben Nasr, Selma; Ben Hadj Ali, Bechir

2014-01-01

Introduction Chez le personnel soignant, le burnout touche un infirmier sur trois. Ce taux est plus élevé dans les unités prenant en charge des patients en fin de vie. L'objectif de notre travail était d'évaluer la fréquence du burnout chez les infirmiers qui travaillent en soins de fin de vie. Méthodes Il s'agit d'une étude descriptive transversale réalisée entre le 1er Avril et le 31 Mai 2010. 60 infirmiers de six services de Sousse et de Monastir (Tunisie) ont été recrutés. L'évaluation du burnout a été réalisée par deux échelles: MBI (Maslach Burnout Inventory) et BMS (Burnout Measure Short version). Résultats La prévalence du burnout était de 70%; il était élevé chez 81.7%. 80% avaient un niveau élevé d'épuisement émotionnel, 70% avaient un niveau élevé de dépersonnalisation et 17% avaient un niveau bas de sentiment d'accomplissement personnel. Le burnout était plus élevé chez les hommes (70,8% vs 69,4%; p=0,013); ceux qui voulaient améliorer les conditions du travail (70.2% vs. 66.7%; p= 0.017); du salaire (70.2% vs. 66.7%; p= 0.017) et chez les infirmiers suivi en psychiatrie (71.4% vs. 69.8%; p= 0.008). Conclusion Dans notre étude le niveau de burnout était élevé chez les infirmiers prenant en charge des patients en fin de vie. Il était associé au sexe masculin et à l'insatisfaction des conditions de travail et du salaire. D'autres études longitudinales sont nécessaires pour suivre l'évolution de ce syndrome et mettre des stratégies de prévention adéquates. PMID:25584122
DETERMINATION OF THE TEMPERATURE DISTRIBUTION THE PERFORATED FINS UNDER

Directory of Open Access Journals (Sweden)

Aziz7 M. Mhamuad

2015-02-01

Full Text Available This work treats the problem of heat transfer for perforated fins under natural convection. The temperature distribution is examined for an array of rectangular fins (15 fins with uniform cross-sectional area (100x270 mm embedded with various vertical body perforations that extend through the fin thickness. The patterns of perforations include 18 circular perforations (holes. Experiments were carried out in an experimental facility that was specifically design and constructed for this purpose. The heat transfer rate and the coefficient of heat transfer increases with perforation diameter increased.
The International Baccalaureate (IB programme: An international gateway to higher education and beyond

Directory of Open Access Journals (Sweden)

Susan E. Saxton

2014-09-01

Full Text Available The aim of this article is to present the International Baccalaureate (IB Programme and briefly outline its core components, followed by a review of what authoritative reports identify as skills for the future, esteemed by universities and the job market. There is a striking match between these skills and IB outcomes; thus, DP graduates perform well in higher education and add to the reputation of those institutions. After a review of the literature, the authors found the IB Diploma Programme has been studied in many countries by both consultants and educational agencies, and also by a wide array of universities themselves; however, there are fewer qualitative studies concerning the degree to which IB graduates display attitudes, values, and behaviours in line with the IB Learner Profile. This is why the authors stress the claims made are supported by examples of significant research, noting that there is a dearth of qualitative longitudinal studies to sufficiently substantiate the affective domain claims that currently rely more on anecdotal evidence. The authors conclude by pointing out more research is needed in order to substantiate anecdotal evidence regarding future employment success for IB Diploma Programme graduates. DOI: 10.18870/hlrc.v4i3.123
Chromium Is Elevated in Fin Whale (Balaenoptera physalus) Skin Tissue and Is Genotoxic to Fin Whale Skin Cells

Science.gov (United States)

Wise, Catherine F.; Wise, Sandra S.; Thompson, W. Douglas; Perkins, Christopher; Wise, John Pierce

2015-01-01

Hexavalent chromium (Cr(VI)) is present in the marine environment and is a known carcinogen and reproductive toxicant. Cr(VI) is the form of chromium that is well absorbed through the cell membrane. It is also the most prevalent form in seawater. We measured the total Cr levels in skin biopsies obtained from healthy free-ranging fin whales from the Gulf of Maine and found elevated levels relative to marine mammals in other parts of the world. The levels in fin whale biopsies ranged from 1.71 ug/g to 19.6 ug/g with an average level of 10.07 ug/g. We also measured the cytotoxicity and genotoxicity of Cr(VI) in fin whale skin cells. We found that particulate and soluble Cr(VI) are both cytotoxic and genotoxic to fin whale skin cells in a concentration-dependent manner. The concentration range used in our cell culture studies used environmentally relevant concentrations based on the biopsy measurements. These data suggest that Cr(VI) may be a concern for whales in the Gulf of Maine. PMID:25805270
Preoperative Concurrent Radiation Therapy and Chemotherapy for Bulky Stage IB2, IIA, and IIB Carcinoma of the Uterine Cervix With Proximal Parametrial Invasion

International Nuclear Information System (INIS)

Huguet, Florence; Cojocariu, Oana-Maria; Levy, Pierre; Lefranc, Jean-Pierre; Darai, Emile; Jannet, Denis; Ansquer, Yan; Lhuillier, Pierre-Eugene; Benifla, Jean-Louis; Seince, Nathalie; Touboul, Emmanuel

2008-01-01

Purpose: To evaluate toxicity, local tumor control, and survival after preoperative chemoradiation for operable bulky cervical carcinoma. Methods and Materials: Between December 1991 and July 2006, 92 patients with operable bulky stage IB2, IIA, and IIB cervical carcinoma without pelvic or para-aortic nodes on pretreatment imaging were treated. Treatment consisted of preoperative external beam pelvic radiation therapy (EBRT) and concomitant chemotherapy (CT) during the first and fourth weeks of radiation combining 5-fluorouracil and cisplatin. The pelvic radiation dose was 40.5 Gy over 4.5 weeks. EBRT was followed by low-dose rate uterovaginal brachytherapy with a total dose of 20 Gy in 62 patients. After a median rest period of 44 days, all patients underwent Class II modified radical hysterectomy with bilateral pelvic lymphadenectomy. Thirty patients who had not received preoperative uterovaginal brachytherapy underwent postoperative low-dose-rate vaginal brachytherapy at a dose of 20 Gy. The mean follow-up was 46 months. Results: Pathologic residual tumor was observed in 43 patients. After multivariate analysis, additional preoperative uterovaginal brachytherapy was the single significant predictive factor for pathologic complete response rate (p = 0.019). The 2- and 5-year disease-free survival (DFS) rates were 80.4% and 72.2%, respectively. Pathologic residual cervical tumor was the single independent factor decreasing the probability of DFS (p = 0.020). Acute toxicities were moderate. Two severe ureteral complications requiring surgical intervention were observed. Conclusions: Concomitant chemoradiation followed by surgery for operable bulky stage I-II cervical carcinoma without clinical lymph node involvement can be used with acceptable toxicity. Pathologic complete response increases the probability of DFS
Vitrification of caudal fin explants from zebrafish adult specimens.

Science.gov (United States)

Cardona-Costa, J; Roig, J; Perez-Camps, M; García-Ximénez, F

2006-01-01

No data on vitrification of tissue samples are available in fishes. Three vitrification solutions were compared: V1: 20% ethylene glycol and 20% dimethyl sulphoxide; V2: 25% propylene glycol and 20% dimethyl sulphoxide, and; V3: 20% propylene glycol and 13% methanol, all three prepared in Hanks' buffered salt solution plus 20 percent FBS, following the same one step vitrification procedure developed in mammals. Caudal fin tissue pieces were vitrified into 0.25 ml plastic straws in 30s and stored in liquid nitrogen for 3 days minimum, warmed (10s in nitrogen vapour and 5s in a 25 degree C water bath) and cultured (L-15 plus 20% FBS at 28.5 degree C). At the third day of culture, both attachment and outgrowing rates were recorded. V3 led to the worst results (8% of attachment rate). V1 and V2 allow higher attachment rates (V1: 63% vs V2: 50%. P < 0.05) but not significantly different outgrowing rates (83% to 94%). Vitrification of caudal fin pieces is advantageous in fish biodiversity conservation, particularly in the wild, due to the simplicity of procedure and equipment.
Multicenter Phase II Study Evaluating Two Cycles of Docetaxel, Cisplatin and Cetuximab as Induction Regimen Prior to Surgery in Chemotherapy-Naive Patients with NSCLC Stage IB-IIIA (INN06-Study.

Directory of Open Access Journals (Sweden)

Wolfgang Hilbe

Full Text Available Different strategies for neoadjuvant chemotherapy in patients with early stage NSCLC have already been evaluated. The aim of this study was to evaluate the tolerability and efficacy of a chemoimmunotherapy when limited to two cycles.Between 01/2007 and 03/2010 41 patients with primarily resectable NSCLC stage IB to IIIA were included. Treatment consisted of two cycles cisplatin (40 mg/m2 d1+2 and docetaxel (75 mg/m2 d1 q3 weeks, accompanied by the administration of cetuximab (400 mg/m2 d1, then 250 mg weekly. The primary endpoint was radiological response according to RECIST.40 patients were evaluable for toxicity, 39 for response. The main grade 3/4 toxicities were: neutropenia 25%, leucopenia 11%, febrile neutropenia 6%, nausea 8% and rash 8%. 20 patients achieved a partial response, 17 a stable disease, 2 were not evaluable. 37 patients (95% underwent surgery and in three of them a complete pathological response was achieved. At a median follow-up of 44.2 months, 41% of the patients had died, median progression-free survival was 22.5 months.Two cycles of cisplatin/ docetaxel/ cetuximab showed promising efficacy in the neoadjuvant treatment of early-stage NSCLC and rapid operation was possible in 95% of patients. Toxicities were manageable and as expected.EU Clinical Trials Register; Eudract-Nr: 2006-004639-31.
Tracing the spatio-temporal dynamics of endangered fin whales (Balaenoptera physalus) within baleen whale (Mysticeti) lineages: a mitogenomic perspective.

Science.gov (United States)

Yu, Jihyun; Nam, Bo-Hye; Yoon, Joon; Kim, Eun Bae; Park, Jung Youn; Kim, Heebal; Yoon, Sook Hee

2017-12-01

To explore the spatio-temporal dynamics of endangered fin whales (Balaenoptera physalus) within the baleen whale (Mysticeti) lineages, we analyzed 148 published mitochondrial genome sequences of baleen whales. We used a Bayesian coalescent approach as well as Bayesian inferences and maximum likelihood methods. The results showed that the fin whales had a single maternal origin, and that there is a significant correlation between geographic location and evolution of global fin whales. The most recent common female ancestor of this species lived approximately 9.88 million years ago (Mya). Here, North Pacific fin whales first appeared about 7.48 Mya, followed by a subsequent divergence in Southern Hemisphere approximately 6.63 Mya and North Atlantic about 4.42 Mya. Relatively recently, approximately 1.76 and 1.42 Mya, there were two additional occurrences of North Pacific populations; one originated from the Southern Hemisphere and the other from an uncertain location. The evolutionary rate of this species was 1.002 × 10 -3 substitutions/site/My. Our Bayesian skyline plot illustrates that the fin whale population has the rapid expansion event since ~ 2.5 Mya, during the Quaternary glaciation stage. Additionally, this study indicates that the fin whale has a sister group relationship with humpback whale (Meganoptera novaeangliae) within the baleen whale lineages. Of the 16 genomic regions, NADH5 showed the most powerful signal for baleen whale phylogenetics. Interestingly, fin whales have 16 species-specific amino acid residues in eight mitochondrial genes: NADH2, COX2, COX3, ATPase6, ATPase8, NADH4, NADH5, and Cytb.
Atom-probe for FinFET dopant characterization

International Nuclear Information System (INIS)

Kambham, A.K.; Mody, J.; Gilbert, M.; Koelling, S.; Vandervorst, W.

2011-01-01

With the continuous shrinking of transistors and advent of new transistor architectures to keep in pace with Moore's law and ITRS goals, there is a rising interest in multigate 3D-devices like FinFETs where the channel is surrounded by gates on multiple surfaces. The performance of these devices depends on the dimensions and the spatial distribution of dopants in source/drain regions of the device. As a result there is a need for new metrology approach/technique to characterize quantitatively the dopant distribution in these devices with nanometer precision in 3D. In recent years, atom probe tomography (APT) has shown its ability to analyze semiconductor and thin insulator materials effectively with sub-nm resolution in 3D. In this paper we will discuss the methodology used to study FinFET-based structures using APT. Whereas challenges and solutions for sample preparation linked to the limited fin dimensions already have been reported before, we report here an approach to prepare fin structures for APT, which based on their processing history (trenches filled with Si) are in principle invisible in FIB and SEM. Hence alternative solutions in locating and positioning them on the APT-tip are presented. We also report on the use of the atom probe results on FinFETs to understand the role of different dopant implantation angles (10 o and 45 o ) when attempting conformal doping of FinFETs and provide a quantitative comparison with alternative approaches such as 1D secondary ion mass spectrometry (SIMS) and theoretical model values. -- Research highlights: → This paper provides the information on how to characterize the FinFET devices using atom probe tomography (APT). → Importance of this work is to assess the performance of these devices at different processing conditions by extracting the compositional profiles. → The performance of these devices depends on the dimensions and the spatial distribution of dopants in source/drain regions. → In this publication we
Study of Swept Angle Effects on Grid Fins Aerodynamics Performance

Science.gov (United States)

Faza, G. A.; Fadillah, H.; Silitonga, F. Y.; Agoes Moelyadi, Mochamad

2018-04-01

Grid fin is an aerodynamic control surface that usually used on missiles and rockets. In the recent several years many researches have conducted to develop a more efficient grid fins. There are many possibilities of geometric combination could be done to improve aerodynamics characteristic of a grid fin. This paper will only discuss about the aerodynamics characteristics of grid fins compared by another grid fins with different swept angle. The methodology that used to compare the aerodynamics is Computational Fluid Dynamics (CFD). The result of this paper might be used for future studies to answer our former question or as a reference for related studies.
Optimization of Peripheral Finned-Tube Evaporators Using Entropy Generation Minimization

OpenAIRE

Pussoli, Bruno; Barbosa Jr., Jader; da Silva, Luciana; Kaviany, Massoud

2012-01-01

The peripheral finned-tube (PFT) is a new geometry for enhanced air-side heat transfer under moisture condensate blockage (evaporators). It consists of individual hexagonal (peripheral) fin arrangements with radial fins whose bases are attached to the tubes and tips are interconnected with the peripheral fins. In this paper, experimentally validated semi-empirical models for the air-side heat transfer and pressure drop are combined with the entropy generation minimization theory to determine ...
Hepatic imaging in stage IV-S neuroblastoma

International Nuclear Information System (INIS)

Franken, E.A. Jr.; Smith, W.L.; Iowa Univ., Iowa City; Cohen, M.D.; Kisker, C.T.; Platz, C.E.

1986-01-01

Stage IV-S neuroblastoma describes a group of infants with tumor spread limited to liver, skin, or bone marrow. Such patients, who constitute about 25% of affected infants with neuroblastoma, may expect spontaneous tumor remission. We report 18 infants with Stage IV-S neuroblastoma, 83% of whom had liver involvement. Imaging investigations included Technetium 99m sulfur colloid scan, ultrasound, and CT. Two patterns of liver metastasis were noted: ill-defined nodules or diffuse tumor throughout the liver. Distinction of normal and abnormal liver with diffuse type metastasis could be quite difficult, particularly with liver scans. We conclude that patients with Stage IV-S neuroblastoma have ultrasound or CT examination as an initial workup, with nuclear medicine scans reserved for followup studies. (orig.)
Alternative Dosing of Exemestane Before Surgery in Treating Postmenopausal Patients With Stage 0-II Estrogen Positive Breast Cancer

Science.gov (United States)

2018-04-09

Estrogen Receptor Positive; Postmenopausal; Stage 0 Breast Cancer AJCC v6 and v7; Stage I Breast Cancer AJCC v7; Stage IA Breast Cancer AJCC v7; Stage IB Breast Cancer AJCC v7; Stage II Breast Cancer AJCC v6 and v7; Stage IIA Breast Cancer AJCC v6 and v7; Stage IIB Breast Cancer AJCC v6 and v7
Purification, crystallization and preliminary X-ray analysis of Enterococcus faecium aminoglycoside-2′′-phosphotransferase-Ib [APH(2′′)-Ib

International Nuclear Information System (INIS)

Walanj, Rupa; Young, Paul; Baker, Heather M.; Baker, Edward N.; Metcalf, Peter; Chow, Joseph W.; Lerner, Stephen; Vakulenko, Sergei; Smith, Clyde A.

2005-01-01

APH(2′′)-Ib is an enzyme responsible for high-level gentamicin resistance in E. faecium isolates. Native crystals of this enzyme have been prepared and preliminary X-ray diffraction experiments have been undertaken. Bacterial resistance to the aminoglycoside antibiotics is primarily the result of deactivation of the drugs. Three families of enzymes are responsible for this activity, with one such family being the aminoglycoside phosphotransferases (APHs). The gene encoding one of these enzymes, APH(2′′)-Ib, has been cloned and the protein (comprising 299 amino-acid residues) expressed in Escherichia coli, purified and crystallized in the presence of 16%(w/v) PEG 3350 and gentamicin. The crystals belong to the monoclinic space group P2 1 , with approximate unit-cell parameters a = 79.7, b = 58.8, c = 81.4 Å, β = 98.4°, and preliminary X-ray diffraction analysis is consistent with the presence of two molecules in the asymmetric unit. Synchrotron diffraction data to approximately 2.65 Å resolution were collected from a native APH(2′′)-Ib crystal at beamline BL9-2 at SSRL (Stanford, CA, USA). Selenium-substituted crystals have also been produced and structure determination is proceeding
Clinical and Microbiological Effect of a Multispecies Probiotic Supplementation in Celiac Patients With Persistent IBS-type Symptoms: A Randomized, Double-Blind, Placebo-controlled, Multicenter Trial.

Science.gov (United States)

Francavilla, Ruggiero; Piccolo, Maria; Francavilla, Antonio; Polimeno, Lorenzo; Semeraro, Francesco; Cristofori, Fernanda; Castellaneta, Stefania; Barone, Michele; Indrio, Flavia; Gobbetti, Marco; De Angelis, Maria

2018-04-23

The goals of this study were to evaluate the efficacy and safety of a probiotic mixture in patients with celiac disease (CD) with irritable bowel syndrome (IBS)-type symptoms despite a strict gluten-free diet (GFD). About 30% of patients with CD adherent to a GFD suffer from IBS-type symptoms; a possible cause resides in the imbalances of the intestinal microbiota in CD. Probiotics may represent a potential treatment. CD patients with IBS-type symptoms entered a prospective, double-blind, randomized placebo-controlled study. A 6-week treatment period was preceded by a 2-week run-in and followed by a 6-week follow-up phase. Clinical data were monitored throughout the study by validated questionnaires: IBS Severity Scoring System (IBS-SSS); Gastrointestinal Symptom Rating Scale (GSRS); Bristol Stool Form Scale (BSFS); and IBS Quality of Life Questionnaire (IBS-QOL). The fecal microbiota were assayed using plate counts and 16S rRNA gene-based analysis. In total, 109 patients were randomized to probiotics (n=54) or placebo (n=55). IBS-SSS and GSRS decreased significantly in probiotics, as compared with placebo [(-15.9%±14.8% vs. 8.2%±25.9%; Psymptoms, in CD patients on strict GFD, and is associated with a modification of gut microbiota, characterized by an increase of bifidobacteria.
Improving the stability of alpha-conotoxin AuIB through N-to-C cyclization

DEFF Research Database (Denmark)

Armishaw, Christopher J; Jensen, Anders A; Balle, Lena D

2011-01-01

Modification of alpha-conotoxin frameworks through cyclization via an oligopeptide linker has previously been shown as an effective strategy for improving in vivo stability. We have extended this strategy by investigating cyclic analogs of alpha-conotoxin AuIB, a selective alpha3beta4 nicotinic a......-AuIB. As such, the cAuIB-2 globular isomer could constitute a useful probe for studying the role of the alpha3beta4 nicotinic acetylcholine receptor in a range of in vivo experimental paradigms....
Experimental investigation of water sprayed finned heat exchanger tube bundles

International Nuclear Information System (INIS)

Sommer, A.

1987-07-01

Experimental investigations have been made to study the performance of two finned tube-bundle heat exchangers (FORGO type) when wetted by water sprays. The heat exchangers are designed to cool water in a dry cooling tower. The test-elements had a frontal area of 1 m 2 . The water sprays were created by 20 nozzles, 200 mm in front of the heat exchangers. Air velocities at the inlet of the coolers were in the range 0,8 m/s to 12 m/s and initial temperature differences ITD reached 45 degrees C. The test facility was designed to determine the combined latent and sensible heat fluxes in the wetted heat exchanger, the airside pressure drop and the air humidity and temperature at the exchanger inlet and outlet, and to measure the weight of the water wetting the cooler's surface. The sprayed test elements were investigated in different positions, but most of the experiments were carried out in the position with the fins horizontal
Fin de Copenhague

DEFF Research Database (Denmark)

Baumeister, Ruth

2016-01-01

FIN DE COPENHAGUE this book by the Danish Cobra artist Asger Jorn and the French philosopher Guy Debord, is the first in a series of two and was published in 1957, shortly before the authors founded the Situationist International. According to Jorn, upon arrival to Copenhagen, they stole some...

Third Stage (S-IVB) At KSC

Science.gov (United States)

1960-01-01

A NASA technician is dwarfed by the gigantic Third Stage (S-IVB) as it rests on supports in a facility at KSC. The towering 363-foot Saturn V was a multi-stage, multi-engine launch vehicle standing taller than the Statue of Liberty. Altogether, the Saturn V engines produced as much power as 85 Hoover Dams.
La Inscripción Ibérica en escritura jonia, Serreta IX.

OpenAIRE

Silgo Gauche, Luís

1997-01-01

S’estudía una nova inscripció sobre làmina de plom, localitzada casualment en l’àrea del poblat ibèric de la Serreta (Alcoi, Cocentaina, Penàguila), en l’escriptura del qual es van emprar caracters greco-ibèrics.
The optimization of longitudinal convective fins with internal heat generation

International Nuclear Information System (INIS)

Razelos, P.

1979-01-01

The solution of the optimization problem for longitudinal convective fins of constant thickness, triangular or parabolic profile, and uniform internal heat generation, is presented. The cases considered are those of a given heat generation density, total heat generation and heat generation per unit width of the fin, when either the heat dissipation or the width of the fin is prescribed. The results are set forth in a nondimensional form, which are presented graphically. The effect of the fin's thermal conductivity upon the optimum dimensions is discussed, and limiting values for the heat generation and the heat dissipation, which may be imposed on the fin for a feasible optimization, are also obtained. (Auth.)
Contributions of type II and Ib/c supernovae to Galactic chemical evolution

International Nuclear Information System (INIS)

Sahijpal Sandeep

2014-01-01

Type II and Ib/c supernovae (SNe II and Ib/c) have made major stellar nucleosynthetic contributions to the inventories of stable nuclides during chemical evolution of the Galaxy. A case study is performed here with the help of recently developed numerical simulations of Galactic chemical evolution in the solar neighborhood to understand the contributions of SNe II and Ib/c by comparing the stellar nucleosynthetic yields obtained by two leading groups in this field. These stellar nucleosynthetic yields differ in terms of their treatment of stellar evolution and nucleosynthesis. The formulation describing Galactic chemical evolution is developed with the recently revised solar metallicity of ∼0.014. Furthermore, the recent nucleosynthetic yields of stellar models based on the revised solar metallicity are also used. The analysis suggests that it could be difficult to explain, in a self-consistent manner, the various features associated with the elemental evolutionary trends over Galactic timescales by any single adopted stellar nucleosynthetic model that incorporates SNe II and Ib/c
Measuring IBS patient reported outcomes with an abdominal pain numeric rating scale: results from the proof cohort

Science.gov (United States)

SPIEGEL, B.; BOLUS, R.; HARRIS, L. A.; LUCAK, S.; NALIBOFF, B.; ESRAILIAN, E.; CHEY, W. D.; LEMBO, A.; KARSAN, H.; TILLISCH, K.; TALLEY, J.; MAYER, E.; CHANG, L.

2009-01-01

Background Controversy exists about how to effectively measure patient reported outcomes in IBS clinical trials. Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The FDA has proposed using the NRS in IBS. Aim To test the psychometrics of an abdominal pain NRS in IBS. Methods We analyzed data from a longitudinal cohort of Rome III IBS subjects. At entry, subjects completed a 10-point NRS, bowel symptoms, IBS severity measurements (IBSSS, FBDSI), health related quality of life indices (IBS-QOL, EQ5D), and the worker productivity activity index (WPAI). We repeated assessments at 3 months along with a response scale to calculate the minimal clinically important difference (MCID). Results There were 277 subjects (82% women; age=42±15) at baseline and 90 at 3 months. The NRS correlated cross-sectionally with IBSSS (r=0.60; p<0.0011), FBDSI (r=0.49; p<0.0001), IBS-QOL (r=0.43; p<0.0001), EQ5D (r=0.48; p<0.0001), presenteeism (r=0.39; p<0.0001), absenteeism (r=0.17; p=0.04), and distension (r=0.46; p<0.0001), but not stool frequency or form. The MCID was 2.2 points, correlating with a 29.5% reduction over time. Conclusions An abdominal pain NRS exhibits excellent validity and can be readily interpreted with an MCID in patients with IBS. These data support the use of the NRS in IBS clinical trials. PMID:19751360
Research on dynamic characteristics of new chaotic-advection fins

International Nuclear Information System (INIS)

Kong Songtao; Dong Qiwu; Liu Minshan; Zhu Qing

2007-01-01

Analysis and the numerical simulation has confirmed that the flow is of the chaotic advection in the flow channel of the new fin. The chaotic advection results in stronger mixing under low Re, and thus enhances the heat transfer and anti-scaling ability. The new fin provides the beneficial exploration to the concept of chaotic advection which applies to the plate-fin heat exchanger. (authors)
More negative self-esteem and inferior coping strategies among patients diagnosed with IBS compared with patients without IBS - a case-control study in primary care

OpenAIRE

Grodzinsky, Ewa; Walter, Susanna; Viktorsson, Lisa; Carlsson, Ann-Kristin; Jones, Michael P.; Olsen Faresjö, Ashild

2015-01-01

Background Irritable Bowel Syndrome (IBS) is a chronic, relapsing gastrointestinal disorder,that affects approximately 10% of the general population and the majority are diagnosed in primary care. IBS has been reported to be associated with altered psychological and cognitive functioning such as mood disturbances, somatization, catastrophizing or altered visceral interoception by negative emotions and stress. The aim was to investigate the psychosocial constructs of self-esteem and sense of...
Stress analysis of plate-fin structures in recuperator

International Nuclear Information System (INIS)

Matsui, Shingo; Muto, Yasushi; Shiina, Yasuaki

2001-01-01

A high performance compact recuperator with 95% effectiveness is required to achieve a high thermal efficiency power generation of up to 50% in High Temperature Gas Cooled Reactor (HTGR) coupled with closed cycle helium gas turbine. Though a plate-fin type heat exchanger is proposed for this recuperator, much research and development works are needed to establish this high performance goal since there exists no state-of-the-art technology in such a high pressure and high temperature one. One of the important works is to establish the structural analysis and evaluation method in this plate-fin type heat exchanger. This paper describes the results of stress analysis of the plate-fin structure under the internal pressure as the first step of this work. First, the modeling of a unit plate-fin structure for the analysis was examined and a three layers model was confirmed to be most adequate. The stress distribution within the structure was clarified by using this model. Second, the three layers model was simplified to one layer model with sufficient accuracy. By using this model, both the effects of an inclined angle of fin and a thickness of separate on the strength were examined parametrically. Under the relevant design conditions, it was revealed that the optimum inclined angle of fin locates in the neighborhood of 76 degree rather than most difficult fabrication angle 90 degree and there is possibility to adopt thinner thickness than 0.5 mm in the current design. (author)
Strain characterization of FinFETs using Raman spectroscopy

International Nuclear Information System (INIS)

Kaleli, B.; Hemert, T. van; Hueting, R.J.E.; Wolters, R.A.M.

2013-01-01

Metal induced strain in the channel region of silicon (Si) fin-field effect transistor (FinFET) devices has been characterized using Raman spectroscopy. The strain originates from the difference in thermal expansion coefficient of Si and titanium-nitride. The Raman map of the device region is used to determine strain in the channel after preparing the device with the focused ion beam milling. Using the Raman peak shift relative to that of relaxed Si, compressive strain values up to – 0.88% have been obtained for a 5 nm wide silicon fin. The strain is found to increase with reducing fin width though it scales less than previously reported results from holographic interferometry. In addition, finite-element method (FEM) simulations have been utilized to analyze the amount of strain generated after thermal processing. It is shown that obtained FEM simulated strain values are in good agreement with the calculated strain values obtained from Raman spectroscopy. - Highlights: ► Strain is characterized in nanoscale devices with Raman spectroscopy. ► There is a fin width dependence of the originated strain. ► Strain levels obtained from this technique is in correlation with device simulations
Microbiota, gastrointestinal infections, low-grade inflammation, and antibiotic therapy in irritable bowel syndrome (IBS: an evidence-based review

Directory of Open Access Journals (Sweden)

Max Schmulson

2014-04-01

Conclusions: Further studies are required to determine the nature of the gut microbiota in IBS and the differences in low-grade inflammation between PI-IBS and non PI-IBS. Rifaximin has shown itself to be an effective treatment for IBS, regardless of prior factors.
The Influence of Culture on the International Management of Shark Finning

Science.gov (United States)

Dell'Apa, Andrea; Chad Smith, M.; Kaneshiro-Pineiro, Mahealani Y.

2014-08-01

Shark finning is prohibited in many countries, but high prices for fins from the Asian market help maintain the international black-market and poaching. Traditional shark fin bans fail to recognize that the main driver of fin exploitation is linked to cultural beliefs about sharks in traditional Chinese culture. Therefore, shark finning should be addressed considering the social science approach as part of the fishery management scheme. This paper investigates the cultural significance of sharks in traditional Chinese and Hawaiian cultures, as valuable examples of how specific differences in cultural beliefs can drive individuals' attitudes toward the property of shark finning. We suggest the use of a social science approach that can be useful in the design of successful education campaigns to help change individuals' attitudes toward shark fin consumption. Finally, alternative management strategies for commercial fishers are provided to maintain self-sustainability of local coastal communities.
The role of stress in IBS symptom severity

Directory of Open Access Journals (Sweden)

Sanda Pletikosic

2016-04-01

Full Text Available Irritable bowel syndrome is regarded as a biopsychosocial disorder, the result of a complex combination of predisposing, precipitating and perpetuating factors. Personality traits, affective status and stress are some of the relevant factors contributing to lower quality of life and symptom exacerbation in IBS patients. In order to examine the role of stress in IBS symptom exacerbation, the aims of this study were to explore the relationship of daily stressful events and symptom severity in a prospective manner and to explore the roles of neuroticism, anxiety, depression and stress in the vicious circle of symptom perpetuation. A total of 49 patients with IBS reported their symptom severity and daily stressful events intensity each day for 14 consecutive days. They also completed the Big five personality inventory, the Beck Depression Inventory and the State-trait anxiety inventory. Cross-correlation analyses were performed on the time series data for daily stress and symptom severity for each participant separately. Four different patterns of relationships were found in different subgroups of participants: positive cross-correlations of symptom severity and stress intensity on the same day; higher symptom severity on days following stressful days; lower symptom severity on days following stressful days; and lower stress intensity on days following severe symptoms. Using average scores for daily stress and symptom severity, as well as scores for neuroticism, anxiety and depression, we performed a path analysis to test a model of symptom exacerbation. It showed that, on the group level, average stress intensity predicts average symptom severity. Neuroticism and anxiety were not significant predictors of symptom severity, while depression showed a marginally significant relationship with symptom severity, mediated by stress intensity. In conclusion, depression and daily stress seem to be important contributors to the vicious circle of IBS symptom
High temperature study of flexible silicon-on-insulator fin field-effect transistors

KAUST Repository

Diab, Amer El Hajj

2014-09-29

We report high temperature electrical transport characteristics of a flexible version of the semiconductor industry\\'s most advanced architecture: fin field-effect transistor on silicon-on-insulator with sub-20 nm fins and high-κ/metal gate stacks. Characterization from room to high temperature (150 °C) was completed to determine temperature dependence of drain current (Ids), gate leakage current (Igs), transconductance (gm), and extracted low-field mobility (μ0). Mobility degradation with temperature is mainly caused by phonon scattering. The other device characteristics show insignificant difference at high temperature which proves the suitability of inorganic flexible electronics with advanced device architecture.
Politics and Pedagogy: Discursive Constructions in the IB "Theory of Knowledge--Guide"

Science.gov (United States)

Smith, Nigel V.; Morgan, Mandy

2010-01-01

The International Baccalaureate (IB) curriculum is increasingly popular in both national and international secondary education settings. The "Theory of knowledge" (TOK) course is cast as the prime example of the international globalised values the IB Diploma represents. This article argues that such a positioning is contested within the TOK…
Steep Dose-Response Relationship for Stage I Non-Small-Cell Lung Cancer Using Hypofractionated High-Dose Irradiation by Real-Time Tumor-Tracking Radiotherapy

International Nuclear Information System (INIS)

Onimaru, Rikiya; Fujino, Masaharu; Yamazaki, Koichi; Onodera, Yuya; Taguchi, Hiroshi; Katoh, Norio; Hommura, Fumihiro; Oizumi, Satoshi; Nishimura, Masaharu; Shirato, Hiroki

2008-01-01

Purpose: To investigate the clinical outcomes of patients with pathologically proven, peripherally located, Stage I non-small-cell lung cancer who had undergone stereotactic body radiotherapy using real-time tumor tracking radiotherapy during the developmental period. Methods and Materials: A total of 41 patients (25 with Stage T1 and 16 with Stage T2) were admitted to the study between February 2000 and June 2005. A 5-mm planning target volume margin was added to the clinical target volume determined with computed tomography at the end of the expiratory phase. The gating window ranged from ±2 to 3 mm. The dose fractionation schedule was 40 or 48 Gy in four fractions within 1 week. The dose was prescribed at the center of the planning target volume, giving more than an 80% dose at the planning target volume periphery. Results: For 28 patients treated with 48 Gy in four fractions, the overall actuarial survival rate at 3 years was 82% for those with Stage IA and 32% for those with Stage IB. For patients treated with 40 Gy in four fractions within 1 week, the overall actuarial survival rate at 3 years was 50% for those with Stage IA and 0% for those with Stage IB. A significant difference was found in local control between those with Stage IB who received 40 Gy vs. 48 Gy (p = 0.0015) but not in those with Stage IA (p = 0.5811). No serious radiation morbidity was observed with either dose schedule. Conclusion: The results of our study have shown that 48 Gy in four fractions within 1 week is a safe and effective treatment for peripherally located, Stage IA non-small-cell lung cancer. A steep dose-response curve between 40 and 48 Gy using a daily dose of 12 Gy delivered within 1 week was identified for Stage IB non-small-cell lung cancer in stereotactic body radiotherapy using real-time tumor tracking radiotherapy
情报研究在FinTech实践中的应用展望%The Application Prospect of Information Science in FinTech Practice

Institute of Scientific and Technical Information of China (English)

徐扬; 刘姝雯; 腾菲; 罗晶

2017-01-01

[目的/意义]针对金融科技(FinTech)发展的特征、现状及问题,探究情报学知识和技术在FinTech实践中的应用和发展方向.[方法/过程]梳理Fintech概念在国内外的发展历程和现状,并从情报学视角,讨论FinTech在特征、应用、监管等方面的研究展望,提出相应的建议.[结果/结论]研究结果表明,情报学与FinTech相辅相成,共同发展.未来,可以进一步强化FinTech业务的信息化与数字化,加强情报分析、商务智能以及情报学视角的大数据分析,为FinTech的发展注入更多的活力.
Forced convection heat transfer correlation for finned plates in a duct

International Nuclear Information System (INIS)

Chae, Myeong-Seon; Moon, Je-Young; Chung, Bum-Jin

2014-01-01

Forced convection heat transfer experiments were conducted for plate-fin in a duct using various fin spacing, fin height, duct width, Reynolds number for Prandtl numbers 2,014. Based upon analogy concept, mass transfer rate were measured instead of heat transfer rates. The heat transfer rates were enhanced with the increase of fin height and decrease of fin spacing as they increase the heat transfer area. Meanwhile, heat transfer rates were impaired with the increase of the duct width as the bypass flows increased to tip clearance region. Forced convection heat transfer correlations were developed for laminar and turbulent flow conditions and for narrow and wide ducts. The work draws attention to the tip clearance on the heat transfer of the finned plate in a duct. (author)
The communication in industrialised building system (IBS) construction project: Virtual environment

Science.gov (United States)

Pozin, Mohd Affendi Ahmad; Nawi, Mohd Nasrun Mohd

2017-10-01

Large portion of numbers team organization in the IBS construction sector is known are being fragmented. That is contributed from a segregation of construction activity thus create team working in virtually. Virtual team are the nature when teams are working in distributed area, across culture and time. Therefore, teams can be respond to the task without relocating to the site project and settle down a problem through information and communication technology (ICT). The emergence of virtual team are carry out by advancements in communication technologies as a medium to improve project team communication in project delivery process on IBS construction. Based on literature review from previous study and data collected from interviewing, this paper aim to identified communication challenges among project team members according to current project development practices in IBS construction project. Hence, in attempt to develop effective communication through the advantages of virtual team approach for IBS construction project. In order to ensure the data is gathered comprehensively and accurately, the data was collected from project managers by using semi structured interview method. It was found that virtual team approach could be enable competitive challenges on complexity in the construction project management process.
Externally finned circular tube immerse in a phase-change material

International Nuclear Information System (INIS)

Alves, C.L.F.; Ismail, K.A.R.

1985-01-01

In an attempt to increase the heat transfer rate and reduce the convective currents during the freezing of phase change materials (PCM) in storage tanks, externally finned circular tubes are studied experimentally. The parameters analysed in this work include number of fins, fin length, initial degree of superheat and freezing time
Investigation of thermal effects on FinFETs in the quasi-ballistic regime

Science.gov (United States)

Yin, Longxiang; Shen, Lei; Di, Shaoyan; Du, Gang; Liu, Xiaoyan

2018-04-01

In this work, the thermal effects of FinFETs in the quasi-ballistic regime are investigated using the Monte Carlo method. Bulk Si nFinFETs with the same fin structure and two different gate lengths L g = 20 and 80 nm are investigated and compared to evaluate the thermal effects on the performance of FinFETs in the quasi-ballistic regime. The on current of the 20 nm FinFET with V gs = 0.7 V does not decrease with increasing lattice temperature (T L) at a high V ds. The electrostatic properties in the 20 nm FinFET are more affected by T L than those in the 80 nm FinFET. However, the electron transport in the 20 nm FinFET is less affected by T L than that in the 80 nm FinFET. The electrostatic properties being more sensitive and the electron transport being less sensitive to thermal effects in the quasi-ballistic regime than in the diffusive regime should be considered for effective device modeling and design.

The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS.

Science.gov (United States)

Staudacher, Heidi M; Whelan, Kevin

2017-08-01

There is an intensifying interest in the interaction between diet and the functional GI symptoms experienced in IBS. Recent studies have used MRI to demonstrate that short-chain fermentable carbohydrates increase small intestinal water volume and colonic gas production that, in those with visceral hypersensitivity, induces functional GI symptoms. Dietary restriction of short-chain fermentable carbohydrates (the low fermentable oligosaccharide, disaccharide, monosaccharide and polyol (FODMAP) diet) is now increasingly used in the clinical setting. Initial research evaluating the efficacy of the low FODMAP diet was limited by retrospective study design and lack of comparator groups, but more recently well-designed clinical trials have been published. There are currently at least 10 randomised controlled trials or randomised comparative trials showing the low FODMAP diet leads to clinical response in 50%-80% of patients with IBS, in particular with improvements in bloating, flatulence, diarrhoea and global symptoms. However, in conjunction with the beneficial clinical impact, recent studies have also demonstrated that the low FODMAP diet leads to profound changes in the microbiota and metabolome, the duration and clinical relevance of which are as yet unknown. This review aims to present recent advances in the understanding of the mechanisms by which the low FODMAP diet impacts on symptoms in IBS, recent evidence for its efficacy, current findings regarding the consequences of the diet on the microbiome and recommendations for areas for future research. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Self-propelled heaving and pitching flexible fin in a quiescent flow

International Nuclear Information System (INIS)

Kim, Boyoung; Park, Sung Goon; Huang, Weixi; Sung, Hyung Jin

2016-01-01

Highlights: • A self-propelled flexible fin with heaving and pitching motions in a quiescent flow has been simulated by using the penalty immersed boundary method. • The cruising speed and the swimming efficiency of the self-propelled fin were determined as functions of the bending coefficient (γ), the heaving amplitude (A_h). • We optimized the cruising speed and the swimming efficiency with respect to γ, f, A_h, A_p, and Δϕ. - Abstract: A self-propelled flexible fin with heaving and pitching motions in a quiescent flow has been simulated by using the penalty immersed boundary method. The flexible fin can move freely in the horizontal direction and the body of the flexible fin moves passively along with the active head motion. The position of the head of the fin was described as a harmonic heaving oscillation in the vertical direction, while the inclination angle of the head was prescribed as a harmonic oscillation with a moving clamped condition for the heaving and pitching fin. The cruising speed and the swimming efficiency of the self-propelled fin were determined as functions of the bending stiffness (γ), the heaving amplitude (A_h), the pitching amplitude (A_p), the flapping frequency (f) and the phase difference (Δϕ) between A_h and A_p. We optimized the cruising speed and the swimming efficiency with respect to γ, f, A_h, A_p and Δϕ. For a certain range of A_p, the swimming efficiency of the heaving and pitching fin is larger than that of a heaving-only fin.
Vortex Shedding from Finned Circular Cylinders

Science.gov (United States)

1980-11-01

FINNED CIRCULAR CYLINDERSo ,rm"" 1..UTNOI .)R*., r. *.040, 111SPOR- / T NuMBII f.John G. elute asOHans J.’/, ugt -. . . , ,<-. -. ,:. =., .. Siil P3RPIO...fins and other sharp protuberances. These purely two-dimensional flows then may be used in a strip theory to include at least some aspects of three...boundary- layer theory . Such a prediction method, together with a technique to provide for a vortex sheet at the separation point, will be included in
Integrated Baseline System (IBS) Version 2.0: Models guide

Energy Technology Data Exchange (ETDEWEB)

1994-03-01

The Integrated Baseline System (IBS) is an emergency management planning and analysis tool being developed under the direction of the US Army Nuclear and Chemical Agency. This Models Guide summarizes the IBS use of several computer models for predicting the results of emergency situations. These include models for predicting dispersion/doses of airborne contaminants, traffic evacuation, explosion effects, heat radiation from a fire, and siren sound transmission. The guide references additional technical documentation on the models when such documentation is available from other sources. The audience for this manual is chiefly emergency management planners and analysts, but also data managers and system managers.
Rendimientos del colágeno, poliornitinas (tipos: IB, IIB y IC) y colágeno mas poliornitina IB, como substratos para el cultivo de ganglios ciliares disociados de embrión de pollo

OpenAIRE

Bustos Ruiz, M.; Alcaín Tejada, F.J.; Padilla-Alvarez, F.

1981-01-01

Dissociated ciliary ganglia of 8 days embryos were cultured in heart conditioned medium, employing differents substrata types: collagen, po¬lyornithines (types: IB,IIB and IC) and collagen plus polyornithine IB. The results from neuron survival (with and without prolongations) and non neuronal cells it obtained graphically. The polyornithines mollecular weights are discussed respect inductor factors binding for conditioned medium. The type IB is better than others types (IIB y IC), but collag...
Generating a robust prediction model for stage I lung adenocarcinoma recurrence after surgical resection.

Science.gov (United States)

Wu, Yu-Chung; Wei, Nien-Chih; Hung, Jung-Jyh; Yeh, Yi-Chen; Su, Li-Jen; Hsu, Wen-Hu; Chou, Teh-Ying

2017-10-03

Lung cancer mortality remains high even after successful resection. Adjuvant treatment benefits stage II and III patients, but not stage I patients, and most studies fail to predict recurrence in stage I patients. Our study included 211 lung adenocarcinoma patients (stages I-IIIA; 81% stage I) who received curative resections at Taipei Veterans General Hospital between January 2001 and December 2012. We generated a prediction model using 153 samples, with validation using an additional 58 clinical outcome-blinded samples. Gene expression profiles were generated using formalin-fixed, paraffin-embedded tissue samples and microarrays. Data analysis was performed using a supervised clustering method. The prediction model generated from mixed stage samples successfully separated patients at high vs. low risk for recurrence. The validation tests hazard ratio (HR = 4.38) was similar to that of the training tests (HR = 4.53), indicating a robust training process. Our prediction model successfully distinguished high- from low-risk stage IA and IB patients, with a difference in 5-year disease-free survival between high- and low-risk patients of 42% for stage IA and 45% for stage IB ( p model for identifying lung adenocarcinoma patients at high risk for recurrence who may benefit from adjuvant therapy. Our prediction performance of the difference in disease free survival between high risk and low risk groups demonstrates more than two fold improvement over earlier published results.
Highly flexible SRAM cells based on novel tri-independent-gate FinFET

Science.gov (United States)

Liu, Chengsheng; Zheng, Fanglin; Sun, Yabin; Li, Xiaojin; Shi, Yanling

2017-10-01

In this paper, a novel tri-independent-gate (TIG) FinFET is proposed for highly flexible SRAM cells design. To mitigate the read-write conflict, two kinds of SRAM cells based on TIG FinFETs are designed, and high tradeoff are obtained between read stability and speed. Both cells can offer multi read operations for frequency requirement with single voltage supply. In the first TIG FinFET SRAM cell, the strength of single-fin access transistor (TIG FinFET) can be flexibly adjusted by selecting five different modes to meet the needs of dynamic frequency design. Compared to the previous double-independent-gate (DIG) FinFET SRAM cell, 12.16% shorter read delay can be achieved with only 1.62% read stability decrement. As for the second TIG FinFET SRAM cell, pass-gate feedback technology is applied and double-fin TIG FinFETs are used as access transistors to solve the severe write-ability degradation. Three modes exist to flexibly adjust read speed and stability, and 68.2% larger write margin and 51.7% shorter write delay are achieved at only the expense of 26.2% increase in leakage power, with the same layout area as conventional FinFET SRAM cell.
Purification, crystallization and preliminary X-ray analysis of Enterococcus faecium aminoglycoside-2′′-phosphotransferase-Ib [APH(2′′)-Ib

Energy Technology Data Exchange (ETDEWEB)

Walanj, Rupa; Young, Paul; Baker, Heather M.; Baker, Edward N.; Metcalf, Peter [Laboratory of Structural Biology, School of Biological Sciences, University of Auckland, Auckland (New Zealand); Chow, Joseph W.; Lerner, Stephen [Division of Infectious Diseases, Wayne State University School of Medicine and VA Medical Center, Detroit, Michigan 48201 (United States); Vakulenko, Sergei [Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556 (United States); Smith, Clyde A., E-mail: csmith@slac.stanford.edu [Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, CA 94025 (United States); Laboratory of Structural Biology, School of Biological Sciences, University of Auckland, Auckland (New Zealand)

2005-04-01

APH(2′′)-Ib is an enzyme responsible for high-level gentamicin resistance in E. faecium isolates. Native crystals of this enzyme have been prepared and preliminary X-ray diffraction experiments have been undertaken. Bacterial resistance to the aminoglycoside antibiotics is primarily the result of deactivation of the drugs. Three families of enzymes are responsible for this activity, with one such family being the aminoglycoside phosphotransferases (APHs). The gene encoding one of these enzymes, APH(2′′)-Ib, has been cloned and the protein (comprising 299 amino-acid residues) expressed in Escherichia coli, purified and crystallized in the presence of 16%(w/v) PEG 3350 and gentamicin. The crystals belong to the monoclinic space group P2{sub 1}, with approximate unit-cell parameters a = 79.7, b = 58.8, c = 81.4 Å, β = 98.4°, and preliminary X-ray diffraction analysis is consistent with the presence of two molecules in the asymmetric unit. Synchrotron diffraction data to approximately 2.65 Å resolution were collected from a native APH(2′′)-Ib crystal at beamline BL9-2 at SSRL (Stanford, CA, USA). Selenium-substituted crystals have also been produced and structure determination is proceeding.
Properties and growth peculiarities of Si{sub 0.30}Ge{sub 0.70} stressor integrated in 14 nm fin-based p-type metal-oxide-semiconductor field-effect transistors

Energy Technology Data Exchange (ETDEWEB)

Hikavyy, A., E-mail: Andriy.Hikavyy@imec.be; Rosseel, E.; Kubicek, S.; Mannaert, G.; Favia, P.; Bender, H.; Loo, R.; Horiguchi, N.

2016-03-01

Integration of Si{sub 0.30}Ge{sub 0.70} in the Source/Drain (S/D) areas of metal oxide semiconductor transistors built according to 14 nm technological node rules has been shown. SiGe properties and growth peculiarities are presented and elaborated. In order to preserve the fin structures during a pre-epitaxy surface preparation, the H{sub 2} bake pressure had to be increased to 19,998 Pa at 800 °C. Influence of this bake on the Si recess in the S/D areas is presented. Excellent quality of both the raised and the embedded Si{sub 0.30}Ge{sub 0.70} was demonstrated by transmission electron microscopy inspections. Energy-dispersive X-ray spectroscopy measurement showed two stages of SiGe growth for the embedded case: first with a lower Ge content at the beginning of the deposition until the (111) facets are formed, and second with a higher Ge content which is governed by the growth on (111) planes. Nano-beam diffraction analysis showed that SiGe grown in the S/D areas of p-type metal-oxide-semiconductor field-effect transistor is fully elastically relaxed in the direction across the fin and partially strained along the fin. Finally, a strain accumulation effect in the chain of transistors has been observed. - Highlights: • Si{sub 0.30}Ge{sub 0.70} stressor has been implemented in the 14 nm technology node CMOS flow. • Embedded and raised variants have been investigated. • High Si{sub 0.30}Ge{sub 0.70} quality was confirmed. • Si{sub 0.30}Ge{sub 0.70} layer is elastically relaxed across the fin direction. • Partial stress presence and stress accumulation effect were observed.
The Significance of Coordination for Industrialised Building System (IBS) Precast Concrete in Construction Industry

OpenAIRE

Fitri Othman Mohd Khairul; Wan Muhammad Wan Mohd Nurdden; Abd Hadi Nurulhudaya; Azman Mohd Azrai

2017-01-01

IBS precast concrete is construction system which is meant to improve the conventional construction process. However IBS precast concrete projects are suffering from serious problems such as cost overrun, delays and less quality of the end product. The absence of coordination is perceived as the reason for this issue. The purpose of this paper is to review the significance of coordination for IBS precast concrete in the construction industry. It if found that the fragmentation which occurs in...
Advantages and Setbacks of Industrialized Building System (IBS) Implementation: A Case Study in Sarawak

OpenAIRE

Sing Sing Wong; Ling Kung Lau

2015-01-01

Industrialized Building System (IBS) is an innovative technique adopted to increase the efficiency, quality and productivity of projects. However, these advantages are proven mainly for projects located in urban areas only. IBS is not a common practice for projects located in rural areas. Although there were studies about IBS in Malaysia about its advantages and setbacks, these studies were focusing on projects located in urban areas located in West Malaysia only. Hence, this paper aids to cl...
El Calloviense de los Ibérides (dominio Ibérico, España. Síntesis bioestratigráfica

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Meléndez, G.

1987-04-01

Full Text Available More than 60 Callovian geological profiles in the Iberides (between Burgos and Alicante have been studied. The Ricla (Zaragoza Callovian section as reference biostratigraphic outline has been established, documenting almost all Callovian Mesogean Zones and Subzones and many biohorizons. The others profiles in relation with the elected as reference are briefly described, standing out the scarce thickness and Upper Callovian and frequently Middle Callovian absence.Se han estudiado más de 60 perfiles geológicos de edad Calloviense en los Ibérides (entre Burgos y Alicante. El Calloviense de Ricla (Zaragoza se toma como esquema bioestratigráfico de referencia, documentándose casi todas las zonas y subzonas y muchos de los biohorizontes del Calloviense de la Mesogea. Los demás perfiles se describen sumariamente en relación al elegido como referencia, destacando su escasa potencia y la falta de Calloviense superior y frecuentemente de Calloviense medio.
Supply Chain Management on IBS Implementation in Klang Valley Construction Industry: Challenges and Issues

Science.gov (United States)

Azrizal Fauzi, Mohd; Hasim, Sulaiman; Awang, Anizah; Ridzuan, Ahmad Ruslan Mohd; Nur Yunus, Juzailah

2017-12-01

Industrialized Building System (IBS) is a system where the components of the building are manufactured in a factory and it will be transported to the site to form the structures. The supply chain management (SCM) is a system where the delivery flows of the IBS products from manufacturers to the site. The aim of this research is to identify the major challenges and to analyze the issues on IBS implementation in SCM in Klang Valley from the manufacturers perspective. The methodology used in this paper is based on primary data through questionnaire and interview. Questionnaires were sent to the Manufacturers. It can be concluded that this paper attempts to present more on the challenges and issues that those companies of manufacturers faced during their success journey in finding integration in their supply chain. The main contributions of this paper are integrating all the supply chain integration challenges and issues on IBS. Therefore, these contributions will be helpful for the organization of manufacturers and IBS players that establish the integration in their SCM.
The Cx43-like connexin protein Cx40.8 is differentially localized during fin ontogeny and fin regeneration.

Directory of Open Access Journals (Sweden)

Sarah V Gerhart

Full Text Available Connexins (Cx are the subunits of gap junctions, membraneous protein channels that permit the exchange of small molecules between adjacent cells. Cx43 is required for cell proliferation in the zebrafish caudal fin. Previously, we found that a Cx43-like connexin, cx40.8, is co-expressed with cx43 in the population of proliferating cells during fin regeneration. Here we demonstrate that Cx40.8 exhibits novel differential subcellular localization in vivo, depending on the growth status of the fin. During fin ontogeny, Cx40.8 is found at the plasma membrane, but Cx40.8 is retained in the Golgi apparatus during regeneration. We next identified a 30 amino acid domain of Cx40.8 responsible for its dynamic localization. One possible explanation for the differential localization is that Cx40.8 contributes to the regulation of Cx43 in vivo, perhaps modifying channel activity during ontogenetic growth. However, we find that the voltage-gating properties of Cx40.8 are similar to Cx43. Together our findings reveal that Cx40.8 exhibits differential subcellular localization in vivo, dependent on a discrete domain in its carboxy terminus. We suggest that the dynamic localization of Cx40.8 differentially influences Cx43-dependent cell proliferation during ontogeny and regeneration.
Hydrodynamical analysis of the effect of fish fins morphology

Science.gov (United States)

Azwadi Che Sidik, Nor; Yen, Tey Wah

2013-12-01

The previous works on the biomechanics of fishes focuses on the locomotion effect of the fish bodies. However, there is quite a insufficiency in unveiling the respective function of fins when the fishes pose statics and exposed to fluid flow. Accordingly, this paper's focus is to investigate the hydrodynamic effect of the fins configuration to the fluid flow of shark-shaped-inspired structure. The drag and lift coefficient is computed for different cases of fish fins addition and configuration. The k-epsilon turbulence model is deployed using finite volume method with the aid of commercial software ANSYS CFX. The finding will demystify some of the functions of the fish's fins in term of their contribution to the hydrodynamic flow around the fishes.
On the Hydrodynamics of Anomalocaris Tail Fins.

Science.gov (United States)

Sheppard, K A; Rival, D E; Caron, J-B

2018-04-25

Anomalocaris canadensis, a soft-bodied stem-group arthropod from the Burgess Shale, is considered the largest predator of the Cambrian period. Thanks to a series of lateral flexible lobes along its dorso-ventrally compressed body, it is generally regarded as an efficient swimmer, well-adapted to its predatory lifestyle. Previous theoretical hydrodynamic simulations have suggested a possible optimum in swimming performance when the lateral lobes performed as a single undulatory lateral fin, comparable to the pectoral fins in skates and rays. However, the role of the unusual fan-like tail of Anomalocaris has not been previously explored. Swimming efficiency and maneuverability deduced from direct hydrodynamic analysis are here studied in a towing tank facility using a three-vane physical model designed as an abstraction of the tail fin. Through direct force measurements, it was found that the model exhibited a region of steady-state lift and drag enhancement at angles of attack greater than 25° when compared to a triangular-shaped reference model. This would suggest that the resultant normal force on the tail fin of Anomalocaris made it well-suited for turning maneuvers, giving it the ability to turn quickly and through small radii of curvature. These results are consistent with an active predatory lifestyle, although detailed kinematic studies integrating the full organism, including the lateral lobes, would be required to test the effect of the tail fin on overall swimming performance. This study also highlights a possible example of evolutionary convergence between the tails of Anomalocaris and birds, which, in both cases, are well-adapted to efficient turning maneuvers.
Performance and optimum design of convective-radiative rectangular fin with convective base heating, wall conduction resistance, and contact resistance between the wall and the fin base

International Nuclear Information System (INIS)

Aziz, Abdul; Beers-Green, Arlen B.

2009-01-01

This paper investigates the performance and optimum design of a longitudinal rectangular fin attached to a convectively heated wall of finite thickness. The exposed surfaces of the fin lose heat to the environmental sink by simultaneous convection and radiation. The tip of the fin is assumed to lose heat by convection and radiation to the same sink. The analysis and optimization of the fin is conducted numerically using the symbolic algebra package Maple. The temperature distribution, the heat transfer rates, and the fin efficiency data is presented illustrating how the thermal performance of the fin is affected by the convection-conduction number, the radiation-conduction number, the base convection Biot number, the convection and radiation Biot numbers at the tip, and the dimensionless sink temperature. Charts are presented showing the relationship between the optimum convection-conduction number and the optimum radiation-conduction number for different values of the base convection Biot number and dimensionless sink temperature and fixed values of the convection and radiation Biot numbers at the tip. Unlike the few other papers which have applied the Adomian's decomposition and the differential quadrature element method to this problem but give illustrative results for specific fin geometry and thermal variables, the present graphical data are generally applicable and can be used by fin designers without delving into the mathematical details of the computational techniques.
A numerical method for PCM-based pin fin heat sinks optimization

International Nuclear Information System (INIS)

Pakrouh, R.; Hosseini, M.J.; Ranjbar, A.A.; Bahrampoury, R.

2015-01-01

Highlights: • Optimization of PCM-based heat sink by using the Taguchi method. • Derivation of optimal PCM percentage to reach the maximum critical time. • Optimization is performed for four different critical temperatures. • Effective design factors are fins’ height and fins’ number. • The optimum configuration depends on geometric properties and the critical temperature. - Abstract: This paper presents a numerical investigation on geometric optimization of PCM-based pin fin heat sinks. Paraffin RT44HC is used as PCM while the fins and heat sink base is made of aluminum. The fins act as thermal conductivity enhancers (TCEs). The main goal of the study is to obtain the configurations that maximize the heat sink operational time. An approach witch couples Taguchi method with numerical simulations is utilized for this purpose. Number of fins, fins height, fins thickness and the base thickness are parameters which are studied for optimization. In this study natural convection and PCM volume variation during melting process are considered in the simulations. Optimization is performed for different critical temperatures of 50 °C, 60 °C, 70 °C and 80 °C. Results show that a complex relation exists between PCM and TCE volume percentages. The optimal case strongly depends on the fins’ number, fins’ height and thickness and also the critical temperature. The optimum PCM percentages are found to be 60.61% (corresponds to 100 pin fin heat sink with 4 mm thick fins) for critical temperature of 50 °C and 82.65% (corresponds to 100 pin fin heat sink with 2 mm thick fins) for other critical temperatures
Studying the Physical Function and Quality of Life Before and After Surgery in Patients With Stage I Cervical Cancer

Science.gov (United States)

2018-02-14

Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Squamous Cell Carcinoma, Not Otherwise Specified; Lymphedema; Sexual Dysfunction and Infertility; Stage IA1 Cervical Cancer AJCC v6 and v7; Stage IA2 Cervical Cancer AJCC v6 and v7; Stage IB1 Cervical Cancer AJCC v6 and v7
Design, Implementation and Control of a Fish Robot with Undulating Fins

Directory of Open Access Journals (Sweden)

Mohsen Siahmansouri

2011-11-01

Full Text Available Biomimetic robots can potentially perform better than conventional robots in underwater vehicle designing. This paper describes the design of the propulsion system and depth control of a robotic fish. In this study, inspired by knife fish, we have designed and implemented an undulating fin to produce propulsive force. This undulating fin is a segmental anal fin that produces sinusoidal wave to propel the robot. The relationship between the individual fin segment and phase angles with the overall fin trajectory has also been discussed. This propulsive force can be adjusted and directed for fish robot manoeuvre by a mechanical system with two servomotors. These servomotors regulate the direction and depth of swimming. A wireless remote control system is designed to adjust the servomotors which enables us to control revolution, speed and phase differences of neighbor servomotors of fins. Finally, Field trials are conducted in an outdoor pool to demonstrate the relationship between robotic fish speed and fin parameters like phase difference, the number of phase and undulatory amplitude.

Nusselt number correlations for microchannel hot water supplier with S-shaped fins

International Nuclear Information System (INIS)

Tsuzuki, Nobuyoshi; Utamura, Motoaki

2008-01-01

Nusselt number correlations for microchannel heat exchanger (MCHE) with S-shaped fins are obtained by numerical experiments using 3D-CFD code and validated by experiments. Refrigerant considered here is carbon dioxide in supercritical state and assumes to operate around the pseudo-critical point. The fluid inlet temperature is defined as 2degC lower or higher than wall temperature for cold or hot side simulations, respectively. The small temperature difference is useful in reducing data because thermal-hydraulic properties can be assumed as constant for the fluid which experiences radical property change along the flow passage of the heat exchanger, e.g. when the fluid passes near pseudo-critical point. Calculations with 20 different temperature points in total are executed and those results are gathered into Nusselt number correlations for each side. The geometry size is almost 0.42% of the whole heat exchanger size. Method to calculate heat transfer performance from the correlations is also found. The heat transfer performance obtained from the correlations is compared with that of another numerical result which is reduced from large geometry and integration. They agree within 3% error and the accuracy of calculation method is confirmed. Experimental results with MCHE also verify the correlations. (author)
FinTech transformation: how it-enabled innovations shape the financial sector

OpenAIRE

Zavolokina, Liudmila; Dolata, Mateusz; Schwabe, Gerhard

2016-01-01

FinTech, the phenomenon which spans over the areas of information technologies and financial innovation, is currently on the rise and is gaining more and more attention from practitioners, investors and researchers. FinTech is broadly discussed by the media, which constitutes its understanding and represents social opinion, however, this perception of FinTech should be supported by empirical evidences. Therefore, we examine five Swiss FinTech companies through the lens of the conceptual frame...
Fish Pectoral Fin Hydrodynamics; Part III: Low Dimensional Models via POD Analysis

Science.gov (United States)

Bozkurttas, M.; Madden, P.

2005-11-01

The highly complex kinematics of the pectoral fin and the resulting hydrodynamics does not lend itself easily to analysis based on simple notions of pitching/heaving/paddling kinematics or lift/drag based propulsive mechanisms. A more inventive approach is needed to dissect the fin gait and gain insight into the hydrodynamic performance of the pectoral fin. The focus of the current work is on the hydrodynamics of the pectoral fin of a bluegill sunfish in steady forward motion. The 3D, time-dependent fin kinematics is obtained via a stereo-videographic technique. We employ proper orthogonal decomposition to extract the essential features of the fin gait and then use CFD to examine the hydrodynamics of simplified gaits synthesized from the POD modes. The POD spectrum shows that the first two, three and five POD modes capture 55%, 67%, and 80% of the motion respectively. The first three modes are in particular highly distinct: Mode-1 is a ``cupping'' motion where the fin cups forward as it is abducted; Mode-2 is an ``expansion'' motion where the fin expands to present a larger area during adduction and finally Mode-3 involves a ``spanwise flick'' of the dorsal edge of the fin. Numerical simulation of flow past fin gaits synthesized from these modes lead to insights into the mechanisms of thrust production; these are discussed in detail.
Topoisomerase IB of Deinococcus radiodurans resolves guanine ...

Indian Academy of Sciences (India)

2015-11-28

Nov 28, 2015 ... All the oligonucleotides men- tioned here were ... further reactions with DraTopoIB were carried out at 37°C ... of G4 DNA moves faster than unfolded and intermolecular .... for its action on intramolecular G4 DNA structure was.
Magmatismo alcalino del Triásico Superior (Noriense) en el extremo NO de la Rama Aragonesa de la Cordillera Ibérica: Modelo de emplazamiento en relación con fallas sin-sedimentarias

OpenAIRE

Sanz, Tomás; Lago San José, Marceliano; Gil Imaz, Andrés; Pocoví Juan, Andrés; Galé, Carlos

2012-01-01

A través de un estudio lito-estratigráfico y tectónico se pretende deducir el contexto estructural en el que se desarrolló el magmatismo alcalino del Triásico Superior, para el margen nor-occidental de la Rama Aragonesa de la Cordillera Ibérica (Sierra del Moncayo). La reactivación del rift Ibérico y el emplazamiento de al menos dos sills en área estudiada, pudo tener lugar a través de la apertura de un número reducido de fallas normales, con orientación actual Ibérica (NO-S...
Thermohydraulic analysis of smooth and finned annular ducts

International Nuclear Information System (INIS)

Braga, C.V.M.

1987-01-01

The present work is concerned with the turbulent heat transfer and pressure drop in smooth and finned annular ducts overage heat transfer coefficients have been obtained by means of the heat exchanger theory. In addition, friction factors have also been determined. The experiments were performed by utilizing four double-pipe heat exchangers. The flowing fluids, in the heat exchangers, were air and water. The average heat transfer coefficients, for air flowing in the annular section, were determined by measuring the overall heat transfer coefficients of the heat exchangers. In order to attain fully developed conditions, the heat exchangers had a starting length of 30 hydraulic diameters. The thermal boundary conditions consisted of uniform temperature on the inner surface, the outer surface being insulated. The heat transfer coefficients and friction factors are presented in dimensionaless forms, as functions of the Reynolds number of the flow. The results for the smooth and finned annular ducts were compared. The purpose of such comparison was to study the influence of the fins on the pressure drop and heat transfer rate. In the case of the finned nular ducts, it is shown that the fin efficiency has some fluence on the heat transfer rates. The, a two-dimensional at transfer analysis was performed in order to obtain the n efficiency and the annular region efficiency. It is also shown that the overall thermal performance of finned surfaces epends mainly on the Nusselt number and on the region eficiency. These parameters are presented as functions of the Reynolds number of the flow and the geometry of the problem. (author) [pt
Heat transfer and pressure drop characteristics of mini-fin structures

International Nuclear Information System (INIS)

Jiang Peixue; Xu Ruina

2007-01-01

Forced convection heat transfer of air and water in bronze and pure copper mini-fin structures and mini-channel structures was investigated experimentally. The mini-fin dimensions were 0.7 mm x 0.2 mm and 0.8 mm x 0.4 mm. The tests included both staggered diamond-shaped and in-line square mini-fin arrangements. The tests investigated the effects of structures, mini-fin dimensions and arrangement, test section materials, and fluid properties on the convection heat transfer and heat transfer enhancement. For the tested conditions, the convection heat transfer coefficient was increased 9-21 fold for water and 12-38 fold for air in the mini-fin structures compared with an empty plate channel. The friction factor and flow resistance in the mini-channel structures and the in-line square mini-fin arrangement were much less than in the staggered diamond-shaped mini-fin arrangement. For the small channel width, W c = 0.2 mm, the convection heat transfer with the in-line square array structure was more intense than with the staggered diamond-shaped structure, the mini-channel structure or the porous media. For the larger channel width, W c = 0.4 mm, the convection heat transfer in the staggered diamond-shaped array structure was more intense than in the others systems while the in-line square structure had the best overall thermal-hydraulic performance
Estilo desornamentado, arquitetura-chã: alguns aspectos do renascimento na Península Ibérica

Directory of Open Access Journals (Sweden)

Andrea Buchidid Loewen

2011-12-01

Full Text Available En el siglo 16, en la Península Ibérica, la asimilación del romano dale impulsión a una corriente arquitectónica en la cual un clasicismo progresivo e la desnudez decorativa anuncian la llegada del llamado Renacimiento. A despecho de sus peculiaridades, tanto el estilo-chão portugués cuanto el desornamentado español se sostienen sobre doctrinas arquitectónicas de origen itálica. Traídas sea por los artífices que estuvieran en tales tierras - o por los arquitectos desde allá llamados a trabajar en la Península - sea por los tratados de arquitectura importados y, más tarde, traducidos al castellano y al portugués, tales doctrinas alimentaran todavía la publicación de otras significativas obras de sistematización teórica, como la sagrediana Medidas del romano. Esto artículo discute tales aspectos del Renacimiento en la Península Ibérica.
SYMPOSIUM REPORT: An Evidence-Based Approach to IBS and CIC: Applying New Advances to Daily Practice

Science.gov (United States)

Chey, William D.

2017-01-01

Many nonpharmacologic and pharmacologic therapies are available to manage irritable bowel syndrome (IBS) and chronic idiopathic constipation (CIC). The American College of Gastroenterology (ACG) regularly publishes reviews on IBS and CIC therapies. The most recent of these reviews was published by the ACG Task Force on the Management of Functional Bowel Disorders in 2014. The key objective of this review was to evaluate the efficacy of therapies for IBS or CIC compared with placebo or no treatment in randomized controlled trials. Evidence-based approaches to managing diarrhea-predominant IBS include dietary measures, such as a diet low in gluten and fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs); loperamide; antispasmodics; peppermint oil; probiotics; tricyclic antidepressants; alosetron; eluxadoline, and rifaximin. Evidence-based approaches to managing constipation-predominant IBS and CIC include fiber, stimulant laxatives, polyethylene glycol, selective serotonin reuptake inhibitors, lubiprostone, and guanylate cyclase agonists. With the growing evidence base for IBS and CIC therapies, it has become increasingly important for clinicians to assess the quality of evidence and understand how to apply it to the care of individual patients. PMID:28729815
Attempt at cloning high-quality goldfish breed 'Ranchu' by fin-cultured cell nuclear transplantation.

Science.gov (United States)

Tanaka, Daisuke; Takahashi, Akito; Takai, Akinori; Ohta, Hiromi; Ueno, Koichi

2012-02-01

The viability of ornamental fish culture relies on the maintenance of high-quality breeds. To improve the profitability of culture operations we attempted to produce cloned fish from the somatic nucleus of the high-quality Japanese goldfish (Carassius auratus auratus) breed 'Ranchu'. We transplanted the nucleus of a cultured fin-cell from an adult Ranchu into the non-enucleated egg of the original goldfish breed 'Wakin'. Of the 2323 eggs we treated, 802 underwent cleavage, 321 reached the blastula stage, and 51 reached the gastrula stage. Two of the gastrulas developed until the hatching stage. A considerable number of nuclear transplants retained only the donor nucleus. Some of these had only a 2n nucleus derived from the same donor fish. Our results provide insights into the process of somatic cell nuclear transplantation in teleosts, and the cloning of Ranchu.
A Numerical Study of Natural Convection Heat Transfer in Fin Ribbed Radiator

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Hua-Shu Dou

2015-01-01

Full Text Available This paper numerically investigates the thermal flow and heat transfer by natural convection in a cavity fixed with a fin array. The computational domain consists of both solid (copper and fluid (air areas. The finite volume method and the SIMPLE scheme are used to simulate the steady flow in the domain. Based on the numerical results, the energy gradient function K of the energy gradient theory is calculated. It is observed from contours of the temperature and energy gradient function that the position where thermal instability takes place correlates well with the region of large K values, which demonstrates that the energy gradient method reveals the physical mechanism of the flow instability. Furthermore, the effects of the fin height, the fin number, and the fin shape on the heat transfer rate are also investigated. It is found that the thermal performance of the fin array is determined by the combined effect of the fin space and fin height. It is also observed that the effect of fin shape on heat transfer is insignificant.
Application of homotopy analysis method and inverse solution of a rectangular wet fin

International Nuclear Information System (INIS)

Panda, Srikumar; Bhowmik, Arka; Das, Ranjan; Repaka, Ramjee; Martha, Subash C.

2014-01-01

Highlights: • Solution of a wet fin with is obtained by homotopy analysis method (HAM). • Present HAM results have been well-validated with literature results. • Inverse analysis is done using genetic algorithm. • Measurement error of ±10–12% (approx.) is found to yield satisfactory reconstructions. - Abstract: This paper presents the analytical solution of a rectangular fin under the simultaneous heat and mass transfer across the fin surface and the fin tip, and estimates the unknown thermal and geometrical configurations of the fin using inverse heat transfer analysis. The local temperature field is obtained by using homotopy analysis method for insulated and convective fin tip boundary conditions. Using genetic algorithm, the thermal and geometrical parameters, viz., thermal conductivity of the material, surface heat transfer coefficient and dimensions of the fin have been simultaneously estimated for the prescribed temperature field. Earlier inverse studies on wet fin have been restricted to the analysis of nonlinear governing equation with either insulated tip condition or finite tip temperature only. The present study developed a closed-form solution with the consideration of nonlinearity effects in both governing equation and boundary condition. The study on inverse optimization leads to many feasible combination of fin materials, thermal conditions and fin dimensions. Thus allows the flexibility for designing a fin under wet conditions, based on multiple combinations of fin materials, fin dimensions and thermal configurations to achieve the required heat transfer duty. It is further determined that the allowable measurement error should be limited to ±10–12% in order to achieve satisfactory reconstruction
Dry/wet performance of a plate-fin air-cooled heat exchanger with continuous corrugated fins

International Nuclear Information System (INIS)

Hauser, S.G.; Kreid, D.K.; Johnson, B.M.

1981-01-01

The performance and operating characteristics of a plate-fin heat exchanger in dry/wet or deluge operations was experimentally determined. Development of the deluge heat/mass transfer model continued. The experiments were conducted in a specially-designed wind tunnel at the PNL. Air that was first heated and humidified to specified conditions was circulated at a controlled rate through a 2 ft x 6 ft heat exchanger module. The heat exchanger used in the tests was a wavy surface, plate fin on tube configuration. Hot water was circulated through the tubes at high flow rates to maintain an essentially isothermal condition on the tube side. Deionized water sprayed on the top of the vertically oriented plate fins was collected at the bottom of the core and recirculated. Instrumentation was provided for measurement of flow rates and thermodynamic conditions in the air, in the core circulation water, and in the deluge water. Measurements of the air side pressure drop and heat rejection rate were made as a function of air flow rate, air inlet temperature and humidity, deluge water flow rate, and the core inclination from the vertical. An overall heat transfer coefficient and an effective deluge film convective coefficient was determined. The deluge model, for predicting heat transfer from a wet finned heat exchanger was further developed and refined, and a major extension of the model was formulated that permits simultaneous calculation of both the heat transfer and evaporation rates from the wetted surface. The experiments showed an increase in the heat rejection rate due to wetting, accompanied by a proportional increase in the air side pressure drop. For operation at the same air side pressure drop, the enhancement ratio Q/sub w//Q/sub d/ varied between 2 and 5 for the conditions tested. Thus, the potential enhancement of heat transfer due to wetting can be substantial
Anisotropic stress in narrow sGe fin field-effect transistor channels measured using nano-focused Raman spectroscopy

Science.gov (United States)

Nuytten, T.; Bogdanowicz, J.; Witters, L.; Eneman, G.; Hantschel, T.; Schulze, A.; Favia, P.; Bender, H.; De Wolf, I.; Vandervorst, W.

2018-05-01

The continued importance of strain engineering in semiconductor technology demands fast and reliable stress metrology that is non-destructive and process line-compatible. Raman spectroscopy meets these requirements but the diffraction limit prevents its application in current and future technology nodes. We show that nano-focused Raman scattering overcomes these limitations and can be combined with oil-immersion to obtain quantitative anisotropic stress measurements. We demonstrate accurate stress characterization in strained Ge fin field-effect transistor channels without sample preparation or advanced microscopy. The detailed analysis of the enhanced Raman response from a periodic array of 20 nm-wide Ge fins provides direct access to the stress levels inside the nanoscale channel, and the results are validated using nano-beam diffraction measurements.
Heat transfer from rotating finned heat exchangers with different orientation angles

Energy Technology Data Exchange (ETDEWEB)

Tawfik, Adel Abdalla [Suez Canal University, Marine Engineering and Naval Architecture Department, Faculty of Engineering, Port Said (Egypt)

2010-03-15

The local and average heat transfer characteristics of spoke like fins that extend outward from a rotating shaft have been determined experimentally. The experiments encompassed a number of geometrical parameters, including the length and chord of the fins, the number of fins deployed around the circumference of the shaft and the orientation angles of the fin. The experiments cover a wider range of rotational speeds, which varies from 25 up to 2,000 rpm. Three wire heat flux sensors have been used in conjunction with a slip ring apparatus to evaluate the local and average heat transfer coefficients. The output results indicated that, the heat transfer transition on rotating fins occurs at Reynolds number lower than encountered on the stationary rectangular fins in crossflow. In general, with non zero incidence angle, the rotating system acts as a fan and creates axial air motion, which enhance the heat transfer rate. However, the effect of orientation angle reduces with increasing the rotational speed. The Nusselt number data are independent of the number of fins in the circumferential array at high rotational speed and are weakly dependent at low Reynolds numbers. To facilitate the use of the results for design, correlations were developed which represent the fin heat transfer coefficient as a continuous function of the investigated independent parameters. (orig.)
Heat transfer and pressure drop characteristics of the tube bank fin heat exchanger with fin punched with flow redistributors and curved triangular vortex generators

Science.gov (United States)

Liu, Song; Jin, Hua; Song, KeWei; Wang, LiangChen; Wu, Xiang; Wang, LiangBi

2017-10-01

The heat transfer performance of the tube bank fin heat exchanger is limited by the air-side thermal resistance. Thus, enhancing the air-side heat transfer is an effective method to improve the performance of the heat exchanger. A new fin pattern with flow redistributors and curved triangular vortex generators is experimentally studied in this paper. The effects of the flow redistributors located in front of the tube stagnation point and the curved vortex generators located around the tube on the characteristics of heat transfer and pressure drop are discussed in detail. A performance comparison is also carried out between the fins with and without flow redistributors. The experimental results show that the flow redistributors stamped out from the fin in front of the tube stagnation points can decrease the friction factor at the cost of decreasing the heat transfer performance. Whether the combination of the flow redistributors and the curved vortex generators will present a better heat transfer performance depends on the size of the curved vortex generators. As for the studied two sizes of vortex generators, the heat transfer performance is promoted by the flow redistributors for the fin with larger size of vortex generators and the performance is suppressed by the flow redistributors for the fin with smaller vortex generators.
Thermal analysis of annular fins with temperature-dependent thermal properties

Institute of Scientific and Technical Information of China (English)

I. G. AKSOY

2013-01-01

The thermal analysis of the annular rectangular profile fins with variable thermal properties is investigated by using the homotopy analysis method (HAM). The thermal conductivity and heat transfer coeﬃcient are assumed to vary with a linear and power-law function of temperature, respectively. The effects of the thermal-geometric fin parameter and the thermal conductivity parameter variations on the temperature distribution and fin eﬃciency are investigated for different heat transfer modes. Results from the HAM are compared with numerical results of the finite difference method (FDM). It can be seen that the variation of dimensionless parameters has a significant effect on the temperature distribution and fin eﬃciency.
Uterine cervical cancer. Preoperative staging with magnetic resonance imaging; Zervixkarzinom. Praeoperatives Staging mittels Magnetresonanztomographie

Energy Technology Data Exchange (ETDEWEB)

Collettini, F.; Hamm, B. [Charite-Universitaetsmedizin Berlin, Campus Charite Mitte, Klinik fuer Radiologie, Berlin (Germany)

2011-07-15

The treatment of uterine cervical carcinoma is largely dependent on the tumor stage. Despite significant inaccuracies in the clinical examination, uterine cervical cancer remains the only gynecological form of cancer still largely staged according to clinical findings. Although imaging is still not included in the staging the recently published revised FIGO (Federation International de Gynecologie et d'Obstetrique) system encourages the use of modern cross-sectional imaging (magnetic resonance imaging MRI and computed tomography CT). Due to its high soft tissue contrast MRI allows excellent non-invasive assessment of the cervix with direct tumor delineation as well as assessment of the prognosis based on morphological factors. Studies in the literature report an accuracy of 93% for MRI in the preoperative assessment of tumor size and in the differentiation of operable from advanced cervical cancer. Therefore MRI is considered to be the optimal modality for diagnostic evaluation starting from FIGO stage IB1, for radiation therapy planning, and for exclusion of recurrence in follow-up. In this paper we give an overview of the role of magnetic resonance imaging in preoperative staging of uterine cervical cancer. (orig.) [German] Die Therapieplanung beim Zervixkarzinom ist weitgehend von der Stadieneinteilung nach FIGO (Federation International de Gynecologie et d'Obstetrique) abhaengig, die trotz erheblicher Ungenauigkeiten bei der klinischen Stadieneinteilung weiterhin aufgrund klinischer Untersuchungsbefunde erfolgt. Obwohl bildgebende Verfahren nach wie vor fuer die Stadieneinteilung nicht vorgesehen sind, wird im kuerzlich erschienen revidierten Stagingsystem der FIGO zum ersten Mal die Verwendung moderner Schnittbilddiagnostik (MRT und CT) befuerwortet. Die MRT ermoeglicht dank ihres hohen Weichteilkontrasts ein ausgezeichnetes nichtinvasives Staging des Zervixkarzinoms mit direkter Tumordarstellung sowie einer Prognoseabschaetzung anhand
Characteristics of a micro-fin evaporator: Theoretical analysis and experimental verification

Directory of Open Access Journals (Sweden)

Zheng Hui-Fan

2013-01-01

Full Text Available A theoretical analysis and experimental verification on the characteristics of a micro-fin evaporator using R290 and R717 as refrigerants were carried out. The heat capacity and heat transfer coefficient of the micro-fin evaporator were investigated under different water mass flow rate, different refrigerant mass flow rate, and different inner tube diameter of micro-fin evaporator. The simulation results of the heat transfer coefficient are fairly in good agreement with the experimental data. The results show that heat capacity and the heat transfer coefficient of the micro-fin evaporator increase with increasing logarithmic mean temperature difference, the water mass flow rate and the refrigerant mass flow rate. Heat capacity of the micro-fin evaporator for diameter 9.52 mm is higher than that of diameter 7.00 mm with using R290 as refrigerant. Heat capacity of the micro-fin evaporator with using R717 as refrigerant is higher than that of R290 as refrigerant. The results of this study can provide useful guidelines for optimal design and operation of micro-fin evaporator in its present or future applications.
Pectoral fin contact as a mechanism for social bonding among dolphins

Science.gov (United States)

Dudzinski, Kathleen; Ribic, Christine

2017-01-01

Bottlenose dolphins are large-brained social mammals residing in a fission-fusion society with relationships that are established and maintained over decades. We examined a decade-long data set of inter-individual pectoral fin contact exchanges to better understand how dolphins share information via tactile contact. Sex and age are significant factors in pectoral fin contact within non-kin dolphin dyads. Adult females shared more pectoral fin contacts with other adult females, while younger females showed no pattern of contact. Males shared more pectoral fin contacts with other males as juveniles and as adults, but showed no difference in the number of touches versus rubs as pectoral fin contacts with other males. Whether in the role of initiator as rubber or initiator as rubbee, male dolphins again preferred other males. These results support the notion that dolphins, especially male dolphins, might use pectoral fin contact as one tool in their repertoire for social bonding to establish, maintain and manage their inter-individual relationships. Additionally, it is also likely that the exchange of pectoral fin contact is developed and refined as individuals age, mature socially, and establish their place within a fission-fusion society.

Enhancement of heat transfer. The performance of micro-fin tubes

International Nuclear Information System (INIS)

Muzzio, A.

2001-01-01

Micro-fin tubes are characterised by numerous, very small integral fins that spiral down the inner surface. A very interesting feature of their performance in flow boiling and condensation is a large heat transfer enhancement accompanied by a low pressure drop penalty. This paper presents a general overview of micro-fin tubes and of their performance in evaporation, condensation and single-phase flow [it
The ties that bind: perceived social support, stress, and IBS in severely affected patients.

Science.gov (United States)

Lackner, J M; Brasel, A M; Quigley, B M; Keefer, L; Krasner, S S; Powell, C; Katz, L A; Sitrin, M D

2010-08-01

This study assessed the association between social support and the severity of irritable bowel syndrome (IBS) symptoms in a sample of severely affected IBS patients recruited to an NIH-funded clinical trial. In addition, we examined if the effects of social support on IBS pain are mediated through the effects on stress. Subjects were 105 Rome II diagnosed IBS patients (F = 85%) who completed seven questionnaires which were collected as part of a pretreatment baseline assessment. Partial correlations were conducted to clarify the relationships between social support and clinically relevant variables with baseline levels of psychopathology, holding constant number of comorbid medical diseases, age, gender, marital status, ethnicity, and education. Analyses indicated that social support was inversely related to IBS symptom severity. Social support was positively related with less severe pain. A similar pattern of data was found for perceived stress but not quality of life impairment. Regression analyses examined if the effects of social support on pain are mediated by stress. The effects of social support on bodily pain were mediated by stress such that the greater the social support the less stress and the less pain. This effect did not hold for symptom severity, quality of life, or psychological distress. This study links the perceived adequacy of social support to the global severity of symptoms of IBS and its cardinal symptom (pain). It also suggests that the mechanism by which social support alleviates pain is through a reduction in stress levels.
Los Grammy Latino, su meta inicial y su fin comercial

Directory of Open Access Journals (Sweden)

Marinés Arroyo Sotomayor

2015-01-01

Full Text Available El artículo refiere lo que es este festival musical que premia el talento latino, quienes participan, su meta inicial y su fin comercial. Muestra que a pesar de la tradición de intolerancia del exilio cubano, la música sirvió, una vez más, como puente de cultura
The Significance of Coordination for Industrialised Building System (IBS Precast Concrete in Construction Industry

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Fitri Othman Mohd Khairul

2017-01-01

Full Text Available IBS precast concrete is construction system which is meant to improve the conventional construction process. However IBS precast concrete projects are suffering from serious problems such as cost overrun, delays and less quality of the end product. The absence of coordination is perceived as the reason for this issue. The purpose of this paper is to review the significance of coordination for IBS precast concrete in the construction industry. It if found that the fragmentation which occurs in the construction industry requires continuity of coordination due to the construction activities are intertwined in nature. Coordination is designated to assist stakeholders in completing and complementing each other with the paramount focus of achieving the objective. Proper coordination is required in delivering the desired construction product at the ideal time, cost and quality. As for the findings, the significance of coordination for IBS precast concrete can be seen through the precast concrete construction phases which consist of planning; design; manufacturing; transportation and installation/construction. These phases are meant to complement construction process with the purpose to reduce issues of fragmentation and enhance IBS precast concrete project delivery.
Critical ICT-Inhibiting Factors on IBS Production Management Processes in the Malaysia Construction Industry

Science.gov (United States)

Ern, Peniel Ang Soon; Kasim, Narimah; Hamid, Zuhairi Abd; Chen, Goh Kai

2017-10-01

Industrialized Building System (IBS) is one of the approaches that had been introduced as an alternative to conventional building method where it becomes the new strategy of enhancing the sustainable construction in current industries while spearheading a huge advancement of benefits with green constructions into the existing industries. The IBS approach is actively promoted through several strategies and incentives as an alternative to conventional building methods. Extensive uptakes of modern Information Communication Technology (ICT) applications are able to support the different IBS processes for effective production. However, it is argued that ICT uptake at the organisational level is still in its infancy. This raises the importance to identify critical inhibitors which are inhibing the effective uptake of ICT in the IBS production management process. Critical inhibitors to ICT uptake were identified through questionnaire survey with the IBS industry stakeholders. The mean index and critical t-values are generated with the use of the quantitative tool, Statistical Package for Social Sciences (SPSS). The top ten priority ranked inhibitors reflect the Cost, People and Process elements to ICT uptake. High costs in acquiring the technologies and resistance to change were some main concerns from the findings.
Mechanism of tonal noise generation from circular cylinder with spiral fin

Science.gov (United States)

Yamashita, Ryo; Hayashi, Hidechito; Okumura, Tetsuya; Hamakawa, Hiromitsu

2014-12-01

The pitch of the spiral finned tube influences seriously to the acoustic resonance in the heat exchanger. In this research, the flow characteristics in relating to the aeolian tone from the finned cylinder are studied by the numerical simulation. It is observed that the tonal noise generated from the finned tube at two pitch spaces. The ratio of the fin pitch to the cylinder diameter is changed at 0.11 and 0.27. The tone level increases and the frequency decreases with the pitch shorter. The separation flow from the cylinder generates the span-wise vortices, Karman vortices, and the separation flow from the fin generates the stream-wise vortices. When the fin pitch ratio is small, the stream-wise vortices line up to span-wise and become weak rapidly. Only the Karman vortices are remained and integrate in span. So the Karman vortex became large. This causes the low frequency and the large aeolian tone.
Fgf16 is essential for pectoral fin bud formation in zebrafish

International Nuclear Information System (INIS)

Nomura, Ryohei; Kamei, Eriko; Hotta, Yuuhei; Konishi, Morichika; Miyake, Ayumi; Itoh, Nobuyuki

2006-01-01

Zebrafish pectoral fin bud formation is an excellent model for studying morphogenesis. Fibroblast growth factors (Fgfs) and sonic hedgehog (shh) are essential for pectoral fin bud formation. We found that Fgf16 was expressed in the apical ectodermal ridge (AER) of fin buds. A knockdown of Fgf16 function resulted in no fin bud outgrowth. Fgf16 is required for cell proliferation and differentiation in the mesenchyme and the AER of the fin buds, respectively. Fgf16 functions downstream of Fgf10, a mesenchymal factor, signaling to induce the expression of Fgf4 and Fgf8 in the AER. Fgf16 in the AER and shh in the zone of polarizing activity (ZPA) interact to induce and/or maintain each other's expression. These findings have revealed that Fgf16, a newly identified AER factor, plays a crucial role in pectoral fin bud outgrowth by mediating the interactions of AER-mesenchyme and AER-ZPA
A Numerical Study on Heat Transfer and Flow Characteristics of a Finned Downhole Coaxial Heat Exchanger

Energy Technology Data Exchange (ETDEWEB)

Park, Chun Dong; Lee, Dong Hyun; Park, Byung-Sik; Choi, Jaejoon [Korea Institute of Energy Research (KIER), Daejeon (Korea, Republic of)

2017-02-15

In this study, the flow and heat transfer characteristics of the finned annular passage were investigated numerically. The annular passage simulates co-axial geothermal heat exchanger, and fins are installed on its inner wall to reduce heat loss from the production passage (annulus) to injection passage (inner pipe). A commercial CFD program, Ansys Fluent, was used with SST k-ω turbulence model. The effects of the geometric parameters of the fin on the inner tube were analyzed under the periodic boundary condition. The result indicated that most parameters had a tendency to increase with an increase in the height and angle of the fin. However, it was confirmed that the Nusselt number of the inner tube on the coaxial 15, 5, 0.3 was lower than that of the smooth tube. Additionally, the Nusselt number of the inner tube exhibited a tendency of decreasing with a decrease in the spacing in Coaxial 15, S{sub f}, 0.3.
Flow-structure Interaction Modeling of a Fish Caudal Fin during Steady Swimming

Science.gov (United States)

Liu, Geng; Geng, Biao; Zheng, Xudong; Xue, Qian; Dong, Haibo

2017-11-01

It's widely thought that the flexibilities of fish fins play critical roles in propulsive performance enhancement (such as thrust augment and efficiency improvement) in nature. In order to explore the formation mechanisms of the fish fin's flexible morphing and its hydrodynamic benefits as well, a high-fidelity flow-structure/membrane interaction modeling of the fish caudal fin is conducted in this work. Following the realistic configuration of the fish caudal fin, a thin membrane supported by a series of beams is constructed. The material properties of the membrane and the beams are reversely determined by the realistic fin morphing obtained from the high-speed videos and the high fidelity flow-structure interaction simulations. With the accurate material property, we investigate the interplay between structure, kinematics and fluid flow in caudal fin propulsion. Detailed analyses on the relationship between the flexural stiffness, fin morphing patterns, hydrodynamic forces and vortex dynamics are then conducted.
Klinefelter's Syndrome with Seizure, Pseudohypoparathyroidism Type Ib and Multiple Endocrine Dysfunctions

Directory of Open Access Journals (Sweden)

Chwen-Yi Yang

2005-12-01

Full Text Available Klinefelter's syndrome is rarely associated with hypocalcemia, especially pseudohypoparathyroidism (PHP type Ib. We describe a case of Klinefelter's syndrome associated with seizure, PHP type Ib and multiple endocrine dysfunctions. A 19-year-old Taiwanese male was admitted due to seizures with loss of consciousness. He had been diagnosed with Klinefelter's syndrome with seizure disorder and hypocalcemia 3 months previously. Physical examination revealed eunuchoidism but no osteodystrophy, while laboratory data revealed severe hypocalcemia, hyperphosphatemia, and elevated parathyroid hormone. Chromosomal study showed 47, XXY. Osteoporosis was found on chest and abdominal radiography. Dense calcification in the cerebrum and cerebellum was shown on brain computed tomography and magnetic resonance imaging. Elevation of the patient's serum calcium level was noted after vitamin D and calcium carbonate supplements were given. Klinefelter's syndrome is rarely associated with PHP type Ib; our patient's hypocalcemia improved after long-term aggressive treatment.
The Species and Origin of Shark Fins in Taiwan's Fishing Ports, Markets, and Customs Detention: A DNA Barcoding Analysis.

Science.gov (United States)

Chuang, Po-Shun; Hung, Tzu-Chiao; Chang, Hung-An; Huang, Chien-Kang; Shiao, Jen-Chieh

2016-01-01

The increasing consumption of shark products, along with the shark's fishing vulnerabilities, has led to the decrease in certain shark populations. In this study we used a DNA barcoding method to identify the species of shark landings at fishing ports, shark fin products in retail stores, and shark fins detained by Taiwan customs. In total we identified 23, 24, and 14 species from 231 fishing landings, 316 fin products, and 113 detained shark fins, respectively. All the three sample sources were dominated by Prionace glauca, which accounted for more than 30% of the collected samples. Over 60% of the species identified in the fin products also appeared in the port landings, suggesting the domestic-dominance of shark fin products in Taiwan. However, international trade also contributes a certain proportion of the fin product markets, as four species identified from the shark fin products are not found in Taiwan's waters, and some domestic-available species were also found in the customs-detained sample. In addition to the species identification, we also found geographical differentiation in the cox1 gene of the common thresher sharks (Alopias vulpinus), the pelagic thresher shark (A. pelagicus), the smooth hammerhead shark (Sphyrna zygaena), and the scalloped hammerhead shark (S. lewini). This result might allow fishing authorities to more effectively trace the origins as well as enforce the management and conservation of these sharks.
The Species and Origin of Shark Fins in Taiwan's Fishing Ports, Markets, and Customs Detention: A DNA Barcoding Analysis.

Directory of Open Access Journals (Sweden)

Po-Shun Chuang

Full Text Available The increasing consumption of shark products, along with the shark's fishing vulnerabilities, has led to the decrease in certain shark populations. In this study we used a DNA barcoding method to identify the species of shark landings at fishing ports, shark fin products in retail stores, and shark fins detained by Taiwan customs. In total we identified 23, 24, and 14 species from 231 fishing landings, 316 fin products, and 113 detained shark fins, respectively. All the three sample sources were dominated by Prionace glauca, which accounted for more than 30% of the collected samples. Over 60% of the species identified in the fin products also appeared in the port landings, suggesting the domestic-dominance of shark fin products in Taiwan. However, international trade also contributes a certain proportion of the fin product markets, as four species identified from the shark fin products are not found in Taiwan's waters, and some domestic-available species were also found in the customs-detained sample. In addition to the species identification, we also found geographical differentiation in the cox1 gene of the common thresher sharks (Alopias vulpinus, the pelagic thresher shark (A. pelagicus, the smooth hammerhead shark (Sphyrna zygaena, and the scalloped hammerhead shark (S. lewini. This result might allow fishing authorities to more effectively trace the origins as well as enforce the management and conservation of these sharks.
Effects of fin shape on condensation in herringbone microfin tubes

Energy Technology Data Exchange (ETDEWEB)

Miyara, Akio [Saga University (Japan). Dept. of Mechanical Engineering; Otsubo, Yusuke; Ohtsuka, Satoshi; Mizuta, Yoshihiko [Saga University (Japan). Graduate School of Science and Engineering

2003-06-01

Effects of fin height and helix angle on condensation inside a herringbone microfin tube have been experimentally investigated with five types of herringbone microfin tubes. Heat transfer coefficients are about 2-4 times higher than that of the helical microfin tube under high mass velocity conditions. In the low mass velocity, they are equal to that of the helical microfin tube. The heat transfer enhancement increases with fin height up to 0.18 mm; higher fin heights show enhancement values similar to the 0.18 mm results. Pressure drop increases with the fin height. Larger helix angle yields higher heat transfer and higher pressure drop. For the lowest fin and/or smallest helix angle, the pressure drop is comparable with that of the helical microfin tube, while the heat transfer enhancement is higher. The enhancement mechanism is discussed from flow pattern observations. Effect of mass transfer resistance for R410A is estimated and negligible effects have been proved. (author)
MULTI-WAVELENGTH OBSERVATIONS OF SUPERNOVA 2011ei: TIME-DEPENDENT CLASSIFICATION OF TYPE IIb AND Ib SUPERNOVAE AND IMPLICATIONS FOR THEIR PROGENITORS

Energy Technology Data Exchange (ETDEWEB)

Milisavljevic, Dan; Margutti, Raffaella; Soderberg, Alicia M.; Chomiuk, Laura; Sanders, Nathan E. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Pignata, Giuliano; Bufano, Filomena [Departamento de Ciencias Fisicas, Universidad Andres Bello, Avda. Republica 252, Santiago (Chile); Fesen, Robert A.; Parrent, Jerod T. [Department of Physics and Astronomy, Dartmouth College, 6127 Wilder Lab, Hanover, NH 03755 (United States); Parker, Stuart [Parkdale Observatory, 225 Warren Road, RDl Oxford, Canterbury 7495 (New Zealand); Mazzali, Paolo [Max-Planck-Institut fuer Astrophysik, Karl-Schwarzschild-Strasse 1, D-85748 Garching (Germany); Pian, Elena [Kavli Institute for Theoretical Physics, Kohn Hall, University of California at Santa Barbara, Santa Barbara, CA 93106-4030 (United States); Pickering, Timothy; Buckley, David A. H.; Crawford, Steven M.; Gulbis, Amanda A. S.; Hettlage, Christian [South African Astronomical Observatory, P.O. Box 9, Observatory 7935, Cape Town (South Africa); Hooper, Eric; Nordsieck, Kenneth H. [Department of Astronomy, University of Wisconsin, Madison, WI 53706 (United States); O' Donoghue, Darragh, E-mail: dmilisav@cfa.harvard.edu [Southern African Large Telescope, P.O. Box 9, Observatory 7935, Cape Town (South Africa); and others

2013-04-10

We present X-ray, UV/optical, and radio observations of the stripped-envelope, core-collapse supernova (SN) 2011ei, one of the least luminous SNe IIb or Ib observed to date. Our observations begin with a discovery within {approx}1 day of explosion and span several months afterward. Early optical spectra exhibit broad, Type II-like hydrogen Balmer profiles that subside rapidly and are replaced by Type Ib-like He-rich features on a timescale of one week. High-cadence monitoring of this transition suggests absorption attributable to a high-velocity ({approx}> 12, 000 km s{sup -1}) H-rich shell, which is likely present in many Type Ib events. Radio observations imply a shock velocity of v Almost-Equal-To 0.13 c and a progenitor star average mass-loss rate of M-dot {approx}1.4 Multiplication-Sign 10{sup -5} M{sub sun} yr{sup -1} (assuming wind velocity v{sub w} = 10{sup 3} km s{sup -1}). This is consistent with independent constraints from deep X-ray observations with Swift-XRT and Chandra. Overall, the multi-wavelength properties of SN 2011ei are consistent with the explosion of a lower-mass (3-4 M{sub Sun }), compact (R{sub *} {approx}< 1 Multiplication-Sign 10{sup 11} cm), He-core star. The star retained a thin hydrogen envelope at the time of explosion, and was embedded in an inhomogeneous circumstellar wind suggestive of modest episodic mass loss. We conclude that SN 2011ei's rapid spectral metamorphosis is indicative of time-dependent classifications that bias estimates of the relative explosion rates for Type IIb and Ib objects, and that important information about a progenitor star's evolutionary state and mass loss immediately prior to SN explosion can be inferred from timely multi-wavelength observations.
Water flow and fin shape polymorphism in coral reef fishes.

Science.gov (United States)

Binning, Sandra A; Roche, Dominique G

2015-03-01

Water flow gradients have been linked to phenotypic differences and swimming performance across a variety of fish assemblages. However, the extent to which water motion shapes patterns of phenotypic divergence within species remains unknown. We tested the generality of the functional relationship between swimming morphology and water flow by exploring the extent of fin and body shape polymorphism in 12 widespread species from three families (Acanthuridae, Labridae, Pomacentridae) of pectoral-fin swimming (labriform) fishes living across localized wave exposure gradients. The pectoral fin shape of Labridae and Acanthuridae species was strongly related to wave exposure: individuals with more tapered, higher aspect ratio (AR) fins were found on windward reef crests, whereas individuals with rounder, lower AR fins were found on leeward, sheltered reefs. Three of seven Pomacentridae species showed similar trends, and pectoral fin shape was also strongly related to wave exposure in pomacentrids when fin aspect ratios of three species were compared across flow habitats at very small spatial scales (fish body fineless ratio across habitats or depths. Contrary to our predictions, there was no pattern relating species' abundances to polymorphism across habitats (i.e., abundance was not higher at sites where morphology is better adapted to the environment). This suggests that there are behavioral and/or physiological mechanisms enabling some species to persist across flow habitats in the absence of morphological differences. We suggest that functional relationships between swimming morphology and water flow not only structure species assemblages, but are yet another important variable contributing to phenotypic differences within species. The close links between fin shape polymorphism and local water flow conditions appear to be important for understanding species' distributions as well as patterns of diversification across environmental gradients.
Hydrodynamic function of dorsal fins in spiny dogfish and bamboo sharks during steady swimming.

Science.gov (United States)

Maia, Anabela; Lauder, George V; Wilga, Cheryl D

2017-11-01

A key feature of fish functional design is the presence of multiple fins that allow thrust vectoring and redirection of fluid momentum to contribute to both steady swimming and maneuvering. A number of previous studies have analyzed the function of dorsal fins in teleost fishes in this context, but the hydrodynamic function of dorsal fins in freely swimming sharks has not been analyzed, despite the potential for differential functional roles between the anterior and posterior dorsal fins. Previous anatomical research has suggested a primarily stabilizing role for shark dorsal fins. We evaluated the generality of this hypothesis by using time-resolved particle image velocimetry to record water flow patterns in the wake of both the anterior and posterior dorsal fins in two species of freely swimming sharks: bamboo sharks ( Chiloscyllium plagiosum ) and spiny dogfish ( Squalus acanthias ). Cross-correlation analysis of consecutive images was used to calculate stroke-averaged mean longitudinal and lateral velocity components, and vorticity. In spiny dogfish, we observed a velocity deficit in the wake of the first dorsal fin and flow acceleration behind the second dorsal fin, indicating that the first dorsal fin experiences net drag while the second dorsal fin can aid in propulsion. In contrast, the wake of both dorsal fins in bamboo sharks displayed increased net flow velocity in the majority of trials, reflecting a thrust contribution to steady swimming. In bamboo sharks, fluid flow in the wake of the second dorsal fin had higher absolute average velocity than that for first dorsal fin, and this may result from a positive vortex interaction between the first and second dorsal fins. These data suggest that the first dorsal fin in spiny dogfish has primarily a stabilizing function, while the second dorsal fin has a propulsive function. In bamboo sharks, both dorsal fins can contribute thrust and should be considered as propulsive adjuncts to the body during steady
En Defensa del Fin de Lucro en Salud.

Directory of Open Access Journals (Sweden)

Ramón Abel Castaño Yepes

2007-06-01

La quinta premisa se deriva de la cuarta y de la segunda, es decir, que si el diseño del sistema de salud introducido por la Ley 100 tiene como elemento distintivo el fin de lucro, entonces el resultado de dicho diseño tiene que ser indeseable, puesto que el fin de lucro es indeseable...
Effects of the partially movable control fin with end plate of underwater vehicle

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Chul-Min Jung

2017-01-01

Full Text Available Underwater torpedo has control fin with very low aspect ratio due to launching from limited size of cylindrical torpedo tube. If the aspect ratio of control fin of underwater vehicle is very low three-dimensional flow around control fin largely reduces control forces. In this study, the end plate was applied to reduce the three-dimensional flow effects of partially movable control fin of underwater vehicle. Through numerical simulations the flow field around control fin was examined with and without end plate for different flap angles. The pressure, vorticity, lift and torque on the control fin were analyzed and compared to experiments. The comparison have shown a reasonable agreement between numerical and experimental results and the effect of end plate on a low aspect ratio control fin. When the end plate was attached to the movable control fin, the lift increased and the actuator shaft torque did not significantly change. As this means less consumption of the actuator shaft torque compared to the control fin that has the same control force, the inner actuator capacity can be reduced and energy consumption can be saved. Considering this, it is expected to be effectively applied to the control fin design of underwater vehicles such as torpedoes.
An experimental investigation into the deployment of 3-D, finned wing and shape memory alloy vortex generators in a forced air convection heat pipe fin stack

International Nuclear Information System (INIS)

Aris, M.S.; McGlen, R.; Owen, I.; Sutcliffe, C.J.

2011-01-01

Forced air convection heat pipe cooling systems play an essential role in the thermal management of electronic and power electronic devices such as microprocessors and IGBT's (Integrated Gate Bipolar Transistors). With increasing heat dissipation from these devices, novel methods of improving the thermal performance of fin stacks attached to the heat pipe condenser section are required. The current work investigates the use of a wing type surface protrusions in the form of 3-D delta wing tabs adhered to the fin surface, thin wings punched-out of the fin material and TiNi shape memory alloy delta wings which changed their angles of attack based on the fin surface temperature. The longitudinal vortices generated from the wing designs induce secondary mixing of the cooler free stream air entering the fin stack with the warmer fluid close to the fin surfaces. The change in angle of the attack of the active delta wings provide heat transfer enhancement while managing flow pressure losses across the fin stack. A heat transfer enhancement of 37% compared to a plain fin stack was obtained from the 3-D tabs in a staggered arrangement. The punched-out delta wings in the staggered and inline arrangements provided enhancements of 30% and 26% respectively. Enhancements from the active delta wings were lower at 16%. However, as these devices reduce the pressure drop through the fin stack by approximately 19% in the de-activate position, over the activated position, a reduction in fan operating cost may be achieved for systems operating with inlet air temperatures below the maximum inlet temperature specification for the device. CFD analysis was also carried out to provide additional detail of the local heat transfer enhancement effects. The CFD results corresponded well with previously published reports and were consistent with the experimental findings. - Highlights: → Heat transfer enhancements of heat pipe fin stacks was successfully achieved using fixed and active delta
How the Change in IBS Criteria From Rome III to Rome IV Impacts on Clinical Characteristics and Key Pathophysiological Factors.

Science.gov (United States)

Aziz, Imran; Törnblom, Hans; Palsson, Olafur S; Whitehead, William E; Simrén, Magnus

2018-06-08

The diagnostic criteria for irritable bowel syndrome (IBS) have recently been updated from Rome III to Rome IV. Whereas in Rome III a diagnosis of IBS entailed chronic abdominal pain or discomfort at least 3 days per month, in Rome IV the term discomfort has been removed and the frequency of abdominal pain increased to at least 1 day per week. We examined how this change in IBS criteria impacts on clinical characteristics and pathophysiological factors. A total of 542 Swedish subjects with Rome III IBS completed a baseline questionnaire enquiring for the number of abdominal pain days in the last 10 days; this was subsequently used as a surrogate marker to identify Rome IV IBS, in that (a) those with 0 or 1 day of pain were classed as Rome IV-negative, and (b) those with ≥2 days of pain were classed as Rome IV-positive. Comparisons were made between Rome IV-positive and -negative IBS groups for demographics, IBS subtype, gastrointestinal and psychological symptoms, somatisation, fatigue, disease-specific quality of life, rectal sensitivity, and oro-anal transit time. Overall, 85% of Rome III IBS patients fulfilled the Rome IV criteria for IBS, but 15% did not. Rome IV-positive subjects were significantly more likely to be female, have poorer quality of life, greater pain severity, bloating, somatisation, fatigue, and rectal sensitivity than Rome IV-negative subjects. There were no differences in severity of anxiety or depression, IBS subtypes, bowel habit dissatisfaction, or oro-anal transit time. Finally, increasing number of pain days correlated positively with symptoms and visceral hypersensitivity. Most Rome III-positive IBS patients seeking healthcare fulfil the Rome IV IBS criteria. They constitute a more severe group than those who lose their IBS diagnosis.

Simulation study of a 3-D device integrating FinFET and UTBFET

KAUST Repository

Fahad, Hossain M.; Hu, Chenming; Hussain, Muhammad Mustafa

2015-01-01

By integrating 3-D nonplanar fins and 2-D ultrathin bodies, wavy FinFETs merge two formerly competing technologies on a silicon-on-insulator platform to deliver enhanced transistor performance compared with conventional trigate Fin
Numerical studies of static aeroelastic effects on grid fin aerodynamic performances

Directory of Open Access Journals (Sweden)

Chengde HUANG

2017-08-01

Full Text Available The grid fin is an unconventional control surface used on missiles and rockets. Although aerodynamics of grid fin has been studied by many researchers, few considers the aeroelastic effects. In this paper, the static aeroelastic simulations are performed by the coupled viscous computational fluid dynamics with structural flexibility method in transonic and supersonic regimes. The developed coupling strategy including fluid–structure interpolation and volume mesh motion schemes is based on radial basis functions. Results are presented for a vertical and a horizontal grid fin mounted on a body. Horizontal fin results show that the deformed fin is swept backward and the axial force is increased. The deformations also induce the movement of center of pressure, causing the reduction and reversal in hinge moment for the transonic flow and the supersonic flow, respectively. For the vertical fin, the local effective incidences are increased due to the deformations so that the deformed normal force is greater than the original one. At high angles of attack, both the deformed and original normal forces experience a sudden reduction due to the interference of leeward separated vortices on the fin. Additionally, the increment in axial force is shown to correlate strongly with the increment in the square of normal force.
Integrated Rudder/Fin Concise Control Based on Frequency Domain Analysis

OpenAIRE

W. Guan; Z. J. Su; G. Q. Zhang

2013-01-01

This paper describes a concise robust controller design of integrated rudder and fin control system in use of the closed loop gain shaping algorithm (CGSA) strategy. Compared with the arbitrary selection of weighting function in integrated rudder and fin H∞ mixed sensitivity control design procedures, the CGSA methods provided a relatively more straightforward and concise design method. Simulations were described that the overall performance of each CGSA rudder and fin control loop and the in...
Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish.

Science.gov (United States)

Akimenko, M A; Johnson, S L; Westerfield, M; Ekker, M

1995-02-01

To study the genetic regulation of growth control and pattern formation during fin development and regeneration, we have analysed the expression of four homeobox genes, msxA, msxB, msxC and msxD in zebrafish fins. The median fin fold, which gives rise to the unpaired fins, expresses these four msx genes during development. Transcripts of the genes are also present in cells of the presumptive pectoral fin buds. The most distal cells, the apical ectodermal ridge of the paired fins and the cleft and flanking cells of the median fin fold express all these msx genes with the exception of msxC. Mesenchymal cells underlying the most distal cells express all four genes. Expression of the msx genes in the fin fold and fin buds is transient and, by 3 days after fertilization, msx expression in the median fin fold falls below levels detectable by in situ hybridization. Although the fins of adult zebrafish normally have levels of msx transcripts undetectable by in situ hybridization, expression of all four genes is strongly reinduced during regeneration of both paired and unpaired fins. Induction of msx gene expression in regenerating caudal fins occurs as early as 30 hours postamputation. As the blastema forms, the levels of expression increase and reach a maximum between the third and fifth days. Then, msx expression progressively declines and disappears by day 12 when the caudal fin has grown back to its normal size. In the regenerating fin, the blastema cells that develop at the tip of each fin ray express msxB and msxC. Cells of the overlying epithelium express msxA and msxD, but do not express msxB or msxC. Amputations at various levels along the proximodistal axis of the fin suggest that msxB expression depends upon the position of the blastema, with cells of the rapidly proliferating proximal blastema expressing higher levels than the cells of the less rapidly proliferating distal blastema. Expression of msxC and msxD is independent of the position of the blastema cell
Gene expression profiles of fin regeneration in loach (Paramisgurnus dabryanu).

Science.gov (United States)

Li, Li; He, Jingya; Wang, Linlin; Chen, Weihua; Chang, Zhongjie

2017-11-01

Teleost fins can regenerate accurate position-matched structure and function after amputation. However, we still lack systematic transcriptional profiling and methodologies to understand the molecular basis of fin regeneration. After histological analysis, we established a suppression subtraction hybridization library containing 418 distinct sequences expressed differentially during the process of blastema formation and differentiation in caudal fin regeneration. Genome ontology and comparative analysis of differential distribution of our data and the reference zebrafish genome showed notable subcategories, including multi-organism processes, response to stimuli, extracellular matrix, antioxidant activity, and cell junction function. KEGG pathway analysis allowed the effective identification of relevant genes in those pathways involved in tissue morphogenesis and regeneration, including tight junction, cell adhesion molecules, mTOR and Jak-STAT signaling pathway. From relevant function subcategories and signaling pathways, 78 clones were examined for further Southern-blot hybridization. Then, 17 genes were chosen and characterized using semi-quantitative PCR. Then 4 candidate genes were identified, including F11r, Mmp9, Agr2 and one without a match to any database. After real-time quantitative PCR, the results showed obvious expression changes in different periods of caudal fin regeneration. We can assume that the 4 candidates, likely valuable genes associated with fin regeneration, deserve additional attention. Thus, our study demonstrated how to investigate the transcript profiles with an emphasis on bioinformatics intervention and how to identify potential genes related to fin regeneration processes. The results also provide a foundation or knowledge for further research into genes and molecular mechanisms of fin regeneration. Copyright © 2017 Elsevier B.V. All rights reserved.
Interferencias morfosintácticas del finés en las producciones en español de escolares bilingües

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Judith Anso Ros

2017-05-01

Los alumnos bilingües de primaria tienen una gran influencia de la lengua dominante, el finés, que se plasma en sus producciones lingüísticas, tanto orales como escritas. El análisis muestra que las principales interferencias morfosintácticas se centran en cuatro tipos distintos: discordancia en género, uso erróneo de preposiciones, uso erróneo de algunos verbos y del tiempo verbal y omisión de artículos. Los resultados muestran como el número de interferencias desciende a través del tiempo, quedando patente la relación inversamente proporcional entre el número de interferencias y competencia, evidenciando una adquisición incompleta de su lengua minoritaria.
Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, CHF functional class Ib

Directory of Open Access Journals (Sweden)

Rodrigo P. Franco

2011-09-01

Full Text Available Degenerative myxomatous mitral valve (DMMV is a heart disease of high incidence in small animal clinical medicine, affecting mainly older dogs and small breeds. Thus, a scientific investigation was performed in order to evaluate the clinical use of the medicines furosemide and enalapril maleate in dogs with this disease in CHF functional class Ib before and after the treatment was established. For this purpose 16 dogs with the given valve disease were used, separated into two groups: the first received furosemide (n=8 and the second received enalapril maleate (n=8 throughout 56 days. The dogs were evaluated in four stages (T0, T14, T28 and T56 day in relation to clinical signs, hematological, biochemical and serum assessment, which included serum angiotensin converting enzyme (ACE and aldosterone, as well as radiography, electrocardiography, Doppler-echocardiography and blood pressure. The results regarding the clinical, hematological and serum chemistry evaluations revealed no significant changes in both groups, but significant reductions in the values of ACE and aldosterone in the group receiving enalapril maleate were verified. The radiographic examination revealed reductions of VHS values and variable Pms wave of the electrocardiogram in both groups, but no changes in blood pressure values were identified. The echocardiogram showed a significant decrease of the variables LVDd/s in the studied groups and the FS% in animals that received only enalapril. Therefore, analysis of results showed that monotherapy based on enalapril maleate showed better efficiency of symptoms control in patients with CHF functional class Ib.
Mixed convection flow of nanofluid in a square enclosure with an intruded rectangular fin

International Nuclear Information System (INIS)

Cong, Ran; Zhou, Xuanyu; De Souza Machado, Bruno; Das, Prodip K.

2016-01-01

Mixed convection flow in enclosures has been a subject of interest for many years due to their ever increasing applications in solar collectors, electronic cooling, lubrication technologies, food processing, and nuclear reactors. In comparison, little effort has been given to the problem of mixed convection in enclosures filled with nanofluids, while the addition of nanoparticles in a fluid base to alter specific material properties is considered a feasible solution for many heat transfer problems. Mixed convection of nanofluids is a challenging problem as the addition of nanoparticles changes the fluid’s thermo-physical properties as well as due to the complex interactions among inertia, viscous, and buoyancy forces. In this study, a two-dimensional steady-state numerical model has been developed to investigate mixed convection flow of nanofluids in a square enclosure with an intruded rectangular fin and to optimize the fin geometry for maximizing the heat transfer using the Constructal design. The model has been developed using ANSYS-FLUENT for various fin geometries. Flow fields, temperature fields, and heat transfer rates are examined for different values of Rayleigh and Reynolds numbers for several geometries of the fin with the aim of maximizing the heat transfer from the fin to the surrounding flow. Outcome of this study provides important insight into the heat transfer behavior of nanofluids, which will help in developing novel geometries with enhanced and controlled heat transfer for solar collectors and electronic devices.
Mixed convection flow of nanofluid in a square enclosure with an intruded rectangular fin

Energy Technology Data Exchange (ETDEWEB)

Cong, Ran; Zhou, Xuanyu; De Souza Machado, Bruno; Das, Prodip K., E-mail: prodip.das@ncl.ac.uk [School of Mechanical and Systems Engineering Newcastle University Newcastle upon Tyne, NE1 7RU United Kingdom (United Kingdom)

2016-07-12

Mixed convection flow in enclosures has been a subject of interest for many years due to their ever increasing applications in solar collectors, electronic cooling, lubrication technologies, food processing, and nuclear reactors. In comparison, little effort has been given to the problem of mixed convection in enclosures filled with nanofluids, while the addition of nanoparticles in a fluid base to alter specific material properties is considered a feasible solution for many heat transfer problems. Mixed convection of nanofluids is a challenging problem as the addition of nanoparticles changes the fluid’s thermo-physical properties as well as due to the complex interactions among inertia, viscous, and buoyancy forces. In this study, a two-dimensional steady-state numerical model has been developed to investigate mixed convection flow of nanofluids in a square enclosure with an intruded rectangular fin and to optimize the fin geometry for maximizing the heat transfer using the Constructal design. The model has been developed using ANSYS-FLUENT for various fin geometries. Flow fields, temperature fields, and heat transfer rates are examined for different values of Rayleigh and Reynolds numbers for several geometries of the fin with the aim of maximizing the heat transfer from the fin to the surrounding flow. Outcome of this study provides important insight into the heat transfer behavior of nanofluids, which will help in developing novel geometries with enhanced and controlled heat transfer for solar collectors and electronic devices.
Necropsy report of a fin whale (Balaenoptera physalus) stranded in Denmark in 2010

DEFF Research Database (Denmark)

Alstrup, Aage K. O.; Hedayat, Abdi; Jensen, Trine Hammer

2013-01-01

There is little detailed information on stranded fin whales (Balaenoptera physalus) in the scientific literature (Notarbartolo di Sciara et al., 2003). In Denmark, at least eight fin whales stranded between the years 1603 and 1958 (Kinze, 1995). On 16 June 2010, a live subadult or adult male fin...... whale stranded in the Bay of Vejle (55º 69' N, 9º 58' E), Denmark. Despite several attempts, it was not possible to rescue the fin whale, which was only partially exposed by the water. The fin whale succumbed after 5 d stranded in shallow water. The dead fin whale was transported to a nearby pier...
The performance of a new gas to gas heat exchanger with strip fin

NARCIS (Netherlands)

Wang, J.; Hirs, Gerard; Rollmann, P.

1999-01-01

A compact gas to gas heat exchanger needs large heat transfer areas on both fluid sides. This can be realised by adding secondary surfaces. The secondary surfaces are plate fin, strip fin, and louvered fin, etc. The fins extend the heat transfer surfaces and promote turbulence. This paper presents a
Performance Analysis of a Self-Propelling Flat Plate Fin with Joint Compliance

Science.gov (United States)

Reddy, N. Srinivasa; Sen, Soumen; Pal, Sumit; Shome, Sankar Nath

2017-12-01

Fish fin muscles are compliant and they regulate the stiffness to suit different swimming conditions. This article attempts to understand the significance of presence of compliance in fin muscle with help of a flexible joint flat plate fin model. Blade element method is employed to model hydrodynamics and to compute the forces of interaction during motion of the plate within fluid. The dynamic model of self-propelling fin is developed through multi-body dynamics approach considering the hydrodynamic forces as external forces acting on the fin. The derived hydrodynamic model is validated with experiments on rigid flat plate fin. The effect of the joint stiffness and flapping frequency on the propulsion speed and efficiency is investigated through simulations using the derived and validated model. The propulsion efficiency is found to be highly influenced by the joint stiffness at a given flapping frequency. The fin attained maximum propulsion efficiency when the joint stiffness is tuned to a value at which flapping frequency matches near natural frequency of the fin. At this tuned joint stiffness and flapping frequency, the resulted Strouhal numbers are observed to fall within the optimum range (0.2 to 0.4) for maximized propulsion efficiency of flying birds and swimming aquatic animals reported in literature.
Development of a Rhizoctonia solani AG1-IB Specific Gene Model Enables Comparative Genome Analyses between Phytopathogenic R. solani AG1-IA, AG1-IB, AG3 and AG8 Isolates.

Directory of Open Access Journals (Sweden)

Daniel Wibberg

Full Text Available Rhizoctonia solani, a soil-born plant pathogenic basidiomycetous fungus, affects various economically important agricultural and horticultural crops. The draft genome sequence for the R. solani AG1-IB isolate 7/3/14 as well as a corresponding transcriptome dataset (Expressed Sequence Tags--ESTs were established previously. Development of a specific R. solani AG1-IB gene model based on GMAP transcript mapping within the eukaryotic gene prediction platform AUGUSTUS allowed detection of new genes and provided insights into the gene structure of this fungus. In total, 12,616 genes were recognized in the genome of the AG1-IB isolate. Analysis of predicted genes by means of different bioinformatics tools revealed new genes whose products potentially are involved in degradation of plant cell wall components, melanin formation and synthesis of secondary metabolites. Comparative genome analyses between members of different R. solani anastomosis groups, namely AG1-IA, AG3 and AG8 and the newly annotated R. solani AG1-IB genome were performed within the comparative genomics platform EDGAR. It appeared that only 21 to 28% of all genes encoded in the draft genomes of the different strains were identified as core genes. Based on Average Nucleotide Identity (ANI and Average Amino-acid Identity (AAI analyses, considerable sequence differences between isolates representing different anastomosis groups were identified. However, R. solani isolates form a distinct cluster in relation to other fungi of the phylum Basidiomycota. The isolate representing AG1-IB encodes significant more genes featuring predictable functions in secondary metabolite production compared to other completely sequenced R. solani strains. The newly established R. solani AG1-IB 7/3/14 gene layout now provides a reliable basis for post-genomics studies.
Robotic Pectoral Fin Thrust Vectoring Using Weighted Gait Combinations

Directory of Open Access Journals (Sweden)

John S. Palmisano

2012-01-01

Full Text Available A method was devised to vector propulsion of a robotic pectoral fin by means of actively controlling fin surface curvature. Separate flapping fin gaits were designed to maximize thrust for each of three different thrust vectors: forward, reverse, and lift. By using weighted combinations of these three pre-determined main gaits, new intermediate hybrid gaits for any desired propulsion vector can be created with smooth transitioning between these gaits. This weighted gait combination (WGC method is applicable to other difficult-to-model actuators. Both 3D unsteady computational fluid dynamics (CFD and experimental results are presented.
BUSINESS STRATEGY OF LARGE CONTRACTORS IN ADOPTING INDUSTRIALISED BUILDING SYSTEM (IBS: THE MALAYSIAN CASE

Directory of Open Access Journals (Sweden)

FRANKY AMBON

2012-12-01

Full Text Available Industrialised Building System (IBS is the term coined by the government and industry in Malaysia to represent the construction industry and the application of prefabrication method in building construction. The purpose of this exploratory research paper is to highlight business strategy being pursued by large Malaysian contractors in adopting IBS. The paper uses case study as research method. The analysis is based primarily on cross-case analysis and pattern matching technique. The paper observes contractors which involved in IBS are part of larger holding companies in a corporate set-up include design and manufacturing subsidiaries. The companies positioned themselves as one-stop total solution provider for IBS and offer a wider range of services from design, production, and installation to clients. To become competitive and able to create total solution, contractors need to establish cluster and consortium of integrated project team by creating a partnership when and where it is needed. A vendor development programme modelled along the lines of the development of automotive industry should also be established. Future empirical studies should extensively examine these areas, especially the development of business model for contractors. The availability of this model could help to accelerate the uptake of IBS among contractors.
Heat transfer in laminar flow for a finned double - tube

International Nuclear Information System (INIS)

Colle, S.

1977-01-01

An analitical study of the steady-state heat transfer in laminar flow in finned double-tube heat exchangers is presented. The fins are plane, straight and continous, equally spaced and are fixed over the external surface of the inner tube. A constant peripheral temperature distribution is assumed to apply over the inner tube surface and each fin, and a constant peripheral heat flux is assumed to apply over the outer tube surface, while the overall heat flux is suposed to be uniform in the longitudinal direction of the duct. The prediction of the thermal performance of the finned double-tube is made by means of the relationship between the Nusselt number, the boundary conditions and the geometric characteristcs of the duct. (author) [pt
Loading the Saturn I S-IV Stage into Pregnant Guppy

Science.gov (United States)

1965-01-01

The photograph shows the loading operation of the Saturn I S-IV stage (second stage) into the Pregnant Guppy at the Redstone Airfield, Huntsville, Alabama. The Pregnant Guppy was a Boeing B-377 Stratocruiser modified to transport various stages of Saturn launch vehicles. The modification project called for lengthening the fuselage to accommodate the S-IV stage. After the flight test of that modification, phase two called for the enlargement of the plane's cabin section to approximately double its normal volume. The fuselage separated just aft of the wing's trailing edge to load and unload the S-IV and other cargoes.
Propulsion of a fin whale (Balaenoptera physalus): why the fin whale is a fast swimmer.

Science.gov (United States)

Bose, N; Lien, J

1989-07-22

Measurements of an immature fin whale (Balaenoptera physalus), which died as a result of entrapment in fishing gear near Frenchmans Cove, Newfoundland (47 degrees 9' N, 55 degrees 25' W), were made to obtain estimates of volume and surface area of the animal. Detailed measurements of the flukes, both planform and sections, were also obtained. A strip theory was developed to calculate the hydrodynamic performance of the whale's flukes as an oscillating propeller. This method is based on linear, two-dimensional, small-amplitude, unsteady hydrofoil theory with correction factors used to account for the effects of finite span and finite amplitude motion. These correction factors were developed from theoretical results of large-amplitude heaving motion and unsteady lifting-surface theory. A model that makes an estimate of the effects of viscous flow on propeller performance was superimposed on the potential-flow results. This model estimates the drag of the hydrofoil sections by assuming that the drag is similar to that of a hydrofoil section in steady flow. The performance characteristics of the flukes of the fin whale were estimated by using this method. The effects of the different correction factors, and of the frictional drag of the fluke sections, are emphasized. Frictional effects in particular were found to reduce the hydrodynamic efficiency of the flukes significantly. The results are discussed and compared with the known characteristics of fin-whale swimming.
Nurturing a FinTech Ecosystem

DEFF Research Database (Denmark)

Leong, Carmen; Tan, Barney; Xiao, Xiao

2017-01-01

Financial technology, or FinTech, involves the design and delivery of financial products and services through technology. It impacts financial institutions, regulators, customers, and merchants across a wide range of industries. Pervasive digital technologies are challenging the fundamentals...... of the highly regulated financial sector, leading to the emergence of non-traditional payment systems, peer-to-peer money exchanges and increased turbulence in currency markets. This case study explores the development of a FinTech company in China that offers microloans to college students. Five lessons...... learned are presented for organizations to better manage the challenges and to leverage the opportunities amidst the disruption of financial sector. Our findings also shed light on how digital technology 1) offers the strategic capability for a firm to occupy a market niche in financial sector, 2) enables...
Pharmacological and safety evaluation of CIGB-300, a casein kinase 2 inhibitor peptide, administered intralesionally to patients with cervical cancer stage IB2/II

Directory of Open Access Journals (Sweden)

Soriano-García JL

2013-08-01

Full Text Available CIGB-300 is a pro-apoptotic casein kinase 2 inhibitor peptide with potential anticancer action. An open-label and dose scaling Phase I trial was carried out to investigate the peptide tumor uptake, pharmacokinetics, toxicity, and levels of a CIGB-300 response biomarker in patients with cervical cancer stage IB2/II. Fourteen patients were included; six of them received 35 mg, 6 received 70 mg and the two remaining patients received 245 mg of CIGB-300 prior chemoradiotherapy. CIGB-300 was applied by intratumor injections during 5-consecutive days. For pharmacokinetic and biodistribution studies, the peptide was radiolabeled with 99mTc in the first administration and whole body gammagraphy and plasma testing were done during 48 h. Data showed that the maximum tolerated dose was 70 mg for CIGB-300 in this clinical setting. Furthermore, an allergic-like syndrome was identified as the dose limiting toxicity, which was well-correlated with plasmatic histamine levels. Importantly, the mean tumor uptake was 14.9 mg and 10.4 mg for CIGB-300 doses of 35 and 70 mg, respectively. Also, the kidneys were the main target organ for drug elimination. Finally, treatment with CIGB-300 significantly reduced the B23/nucleophosmin levels in tumor specimens. CIGB-300 meets potentialities to be tested in future trials in a neoadjuvant setting prior to chemoradiotherapy in cervical cancer.

Optimization of geometric parameters of heat exchange pipes pin finning

Science.gov (United States)

Akulov, K. A.; Golik, V. V.; Voronin, K. S.; Zakirzakov, A. G.

2018-05-01

The work is devoted to optimization of geometric parameters of the pin finning of heat-exchanging pipes. Pin fins were considered from the point of view of mechanics of a deformed solid body as overhang beams with a uniformly distributed load. It was found out under what geometric parameters of the nib (diameter and length); the stresses in it from the influence of the washer fluid will not exceed the yield strength of the material (aluminum). Optimal values of the geometric parameters of nibs were obtained for different velocities of the medium washed by them. As a flow medium, water and air were chosen, and the cross section of the nibs was round and square. Pin finning turned out to be more than 3 times more compact than circumferential finning, so its use makes it possible to increase the number of fins per meter of the heat-exchanging pipe. And it is well-known that this is the main method for increasing the heat transfer of a convective surface, giving them an indisputable advantage.
Numerical simulation of natural convection in annuli with internal fins

International Nuclear Information System (INIS)

Ha, Man Yeong; Kim, Joo Goo

2004-01-01

The solution for the natural convection in internally finned horizontal annuli is obtained by using a numerical simulation of time-dependent and two-dimensional governing equations. The fins existing in annuli influence the flow pattern, temperature distribution and heat transfer rate. The variations of the fin configuration suppress or accelerate the free convective effects compared to those of the smooth tubes. The effects of fin configuration, number of fins and ratio of annulus gap width to the inner cylinder radius on the fluid flow and heat transfer in annuli are demonstrated by the distribution of the velocity vector, isotherms and streamlines. The governing equations are solved efficiently by using a parallel implementation. The technique is adopted for reduction of the computation cost. The parallelization is performed with the domain decomposition technique and message passing between sub-domains on the basis of the MPI library. The results from parallel computation reveal in consistency with those of the sequential program. Moreover, the speed-up ratio shows linearity with the number of processor
Experimental analysis on frosting characteristic of SK-type finned refrigerating heat exchanger with large-diameter circular holes

International Nuclear Information System (INIS)

Fang, Zhao-song; Wang, Hou-hua; Zhang, Jie; Wu, Wei-wei

2014-01-01

This paper presents the construction of both a plane fin-and-tube heat exchanger and a SK-type fin-and-tube heat exchanger. Based on plane fin-and-tube heat exchanger, comparative industrial prototype experiments of SK-type fin-and-tube heat exchanger energy efficiency performance were carried out in the artificial climate chamber. Test results confirmed several findings: when the amount of the refrigerant charged is the same and face velocity u = 3.75 m s −1 , SK-type fin-and-tube heat exchanger refrigeration capacity increases by an average of 9.13%; energy consumption reduces by an average of 11.25%, coefficient of performance (COP) of heat exchanger increases by an average of 22.65% with continuous operation during the first 2 h. Also, when the operation time exceeds 2 h, the COP of both types of heat exchangers are both less than 0.6, illustrating that under frost conditions, the defrost interval should not be too long, otherwise energy consumption may sharply spike. - Highlights: •The large holes of SK-type induced the generation of turbulence flow. •The refrigeration capacity and COP of SK-type exceeds that of plane one. •The SK-type fin-and-tube heat exchanger is a new kind of heat transfer equipment. •The defrost interval should not exceed 2 h under frost conditions
Towards Integrated Team Practice: A Case of Malaysian Industrialised Building System (IBS Construction Projects

Directory of Open Access Journals (Sweden)

Mohd Nawi Mohd Nasrun

2014-01-01

Full Text Available Problems associated with fragmentation in the traditional construction process, such as isolation of professionals, lack of co-ordination between design and construction, and the sequential manner of its processes, has impacted on construction performance leading to a lack of integration, wastage, low productivity and efficiency. Integrated team practice is perceived as paramount. Unfortunately, there has a limitation of study focus on the dimension of fully integrated team especially for Malaysian Industrialised Building System (IBS projects. Accordingly, this research paper explores and identifies the dimension of fully integrated team from the traditional approach and conduct a validation process for implementing it in Malaysian IBS projects. The research presented uses interviews case study to obtain qualitative data. It was found that the dimension of fully integrated team from the traditional construction process could apply to the Malaysian IBS projects. Suggestions on how an integrated team practice in IBS design and construction process in order to minimise the fragmentation gaps will be concluded.
Collector Efficiency in Downward-Type Internal-Recycle Solar Air Heaters with Attached Fins

Directory of Open Access Journals (Sweden)

Chii-Dong Ho

2013-10-01

Full Text Available The internal-recycle operation effect on collector efficiency in downward-type rectangular solar air heaters with attached fins is theoretically investigated. It is found that considerable collector efficiency is obtainable if the collector has attached fins and the operation is carried out with internal recycling. The recycling operation increases the fluid velocity to decrease the heat transfer resistance, compensating for the undesirable effect of decreasing the heat transfer driving force (temperature difference due to remixing. The attached fins provide an enlarged heat transfer area. The order of performance in a device of same size is: double pass with recycle and fins > double pass with recycle but without fins > single pass without recycle and fins.
Travel Tips Help IBS Sufferers Enjoy Their Vacations

Science.gov (United States)

... can feel more in control when traveling." IFFGD's travel tips include: Allow enough time in the morning to get to the airport ... Heartache 2004-0929 Norton Honored 2004-0525 IBS Travel Tips ... Real World 2001-1119 Heartburn or Heart Attack Commentary ...
Fin field effect transistor directionality impacts printing of implantation shapes

Science.gov (United States)

Wang, Xiren; Granik, Yuri

2018-01-01

In modern integrated circuit (IC) fabrication processes, the photoresist receives considerable illumination energy that is reflected by underlying topography during optical lithography of implantation layers. Bottom antireflective coating (BARC) is helpful to mitigate the reflection. Often, however, BARC is not used, because its removal is technically challenging, in addition to its relatively high economic cost. Furthermore, the advanced technology nodes, such as 14/10-nm nodes, have introduced fin field effect transistor (FinFET), which makes reflection from nonuniform silicon substrates exceptionally complicated. Therefore, modeling reflection from topography becomes obligatory to accurately predict printing of implantation shapes. Typically, FinFET is always fixed in one direction in realistic designs. However, the same implantation rectangle may be oriented in either horizontal or vertical direction. Then, there are two types of relations between the critical dimension (CD) and FinFET, namely a parallel-to and a perpendicular-to relation. We examine the fin directionality impact on CD. We found that this impact may be considerable in some cases. We use our in-house rigorous optical topography simulator to reveal underlining physical reasons. One of the major causes of the CD differences is that in the parallel orientation, the solid sidewalls of the fins conduct considerable light reflections unlike for the perpendicular orientation. This finding can aid the compact modeling in optical proximity correction of implantation masks.
Experimental study on void fraction of two-phase flow inside a micro-fin tube

OpenAIRE

Koyama, Shigeru; Chen, Yongchang; Kitano, Ryuji; Kuwahara, Ken

2001-01-01

In this paper the void fraction and flow pattern of the two-phase flow in a micro-fin tube were investigated experimentally for a pure refrigerant HFC134a. The experiment was carried out at a pressure range of 0.6 and 1.2MPa with mass velocities of 90 and 180kg/m^2 s, in which the vapor quality varied from 0 to 1. The void fraction was measured by means of simultaneously closing valves of both sides of the test tube at adiabatic condition. Experimental results for the micro-fin tube were comp...
Protective Role of Comfrey Leave Extracts on UV-induced Zebrafish Fin Damage

OpenAIRE

Cheng, Chien-Chung; Chou, Chi-Yuan; Chang, Yao-Chin; Wang, Hsuan-Wen; Wen, Chi-Chung; Chen, Yau-Hung

2014-01-01

In zebrafish, UV exposure leads to fin malformation phenotypes including fin reduction or absence. The present study evaluated UV-protective activities of comfrey leaves extracts in a zebrafish model by recording fin morphological changes. Chemopreventive effects of comfrey leave extracts were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. The results showed that (1) the mean times of return to normal fin in the UV+comfrey (50 and 100 ppm) groups were 3.43 and ...
Characteristics and formation mechanism for stainless steel fiber with periodic micro-fins

Science.gov (United States)

Tang, Tao; Wan, Zhenping; Lu, Longsheng; Tang, Yong

2016-05-01

Metal fibers have been widely used in many industrial applications due to their unique advantages. In certain applications, such as catalyst supports or orthopedic implants, a rough surface or tiny outshoots on the surface of metal fibers to increase surface area are needed. However, it has not been concerned about the surface morphologies of metal fiber in the current research of metal fiber manufacturing. In this paper, a special multi-tooth tool composed of a row of triangular tiny teeth is designed. The entire cutting layer of multi-tooth tool bifurcates into several thin cutting layers due to tiny teeth involved in cutting. As a result, several stainless steel fibers with periodic micro-fins are produced simultaneously. Morphology of periodic micro-fins is found to be diverse and can be classified into three categories: unilateral plane, unilateral tapering and bilateral. There are two forming mechanisms for the micro-fins. One is that periodic burrs remained on the free side of cutting layer of a tiny tooth create micro-fins of stainless steel fiber produced by the next neighboring tiny tooth; the other is that the connections between two fibers stuck together come to be micro-fins if the two fibers are finally detached. Influence of cutting conditions on formation of micro-fins is investigated. Experimental results show that cutting depth has no significant effect on micro-fin formation, high cutting speed is conducive to micro-fin formation, and feed should be between 0.12 mm/r and 0.2 mm/r to reliably obtain stainless steel fiber with micro-fins. This research presents a new pattern of stainless steel fiber characterized by periodic micro-fins formed on the edge of fiber and its manufacturing method.
印度尼西亚FinTech生态圈的发展及机遇%Development and Opportunities of FinTech Ecosystem in Indonesia

Institute of Scientific and Technical Information of China (English)

熊琦

2018-01-01

印尼FinTech是新兴行业,自2014年以来呈现井喷式增长,其生态圈竞争优势主要体现在需求方面:潜在市场巨大,资本投入增长迅猛,但人才优势尚显不足,政策上积极学习国际经验,已推出"监管沙盒"和针对P2P的严格管控法规,从长远看能促进FinTech包容性发展;印尼银行渗透率低,银行分支机构少,物理基础设施建设不足,且印尼人的FinTech意识较弱,中国FinTech企业在印尼的个人消贷和中小企业融资领域将大有作为;可加大对印尼的资金支持以帮助当地建设,更好地进行合作发展FinTech行业,实现共赢.
A Novel Implementation of a Flexible Robotic Fin Actuated by Shape Memory Alloy

Institute of Scientific and Technical Information of China (English)

Qin Yan; Lei Wang; Bo Liu; Jie Yang; Shiwu Zhang

2012-01-01

In this paper,study of a novel flexible robotic-fin actuated by Shape Memory Alloy (SMA) is presented.The developed robotic fin is capable of implementing various 3-Dimensional (3D) motions,which plays an important role in robot propulsion and maneuverability.Firstly,the morphological and mechanics parameters of a real pectoral fin from a carp are investigated.Secondly,a detailed design of the flexible pectoral fin driven by SMA is presented according to the previous morphological and mechanics analyses.Thirdly,a simplified theoretical model on the SMA fin plate is derived.The thermodynamics of the SMA plate and the relationship between curvature and phase transformation are analyzed.Finally,several simulations and model experiments are conducted according to the previous analyses.The results of the experiments are useful for the control of the robotic fin.The experimental results reveal that the SMA actuated fin ray has a good actuating performance.
The FLUFF code for calculating finned surface heat transfer -description and user's guide

International Nuclear Information System (INIS)

Fry, C.J.

1985-08-01

FLUFF is a computer code for calculating heat transfer from finned surfaces by convection and radiation. It can also represent heat transfer by radiation to a partially emitting and absorbing medium within the fin cavity. The FLUFF code is useful not only for studying the behaviour of finned surfaces but also for deriving heat fluxes which can be applied as boundary conditions to other heat transfer codes. In this way models of bodies with finned surfaces may be greatly simplified since the fins need not be explicitly represented. (author)
Age estimation of burbot using pectoral fin rays, brachiostegal rays, and otoliths

Science.gov (United States)

Klein, Zachary B.; Terrazas, Marc M.; Quist, Michael C.

2014-01-01

Throughout much of its native distribution, burbot (Lota lota) is a species of conservation concern. Understanding dynamic rate functions is critical for the effective management of sensitive burbot populations, which necessitates accurate and precise age estimates. Managing sensitive burbot populations requires an accurate and precise non-lethal alternative. In an effort to identify a non-lethal ageing structure, we compared the precision of age estimates obtained from otoliths, pectoral fin rays, dorsal fin rays and branchiostegal rays from 208 burbot collected from the Green River drainage, Wyoming. Additionally, we compared the accuracy of age estimates from pectoral fin rays, dorsal fin rays and branchiostegal rays to those of otoliths. Dorsal fin rays were immediately deemed a poor ageing structure and removed from further analysis. Age-bias plots of consensus ages derived from branchiostegal rays and pectoral fin rays were appreciably different from those obtained from otoliths. Exact agreement between readers and reader confidence was highest for otoliths and lowest for branchiostegal rays. Age-bias plots indicated that age estimates obtained from branchiostegal rays and pectoral fin rays were substantially different from age estimates obtained from otoliths. Our results indicate that otoliths provide the most precise age estimates for burbot.
Evaluation of integrally finned cladding for LMFBR fuel pins

International Nuclear Information System (INIS)

Cantley, D.A.; Sutherland, W.H.

1975-01-01

An integral fin design effectively reduces the coolant temperature gradients within an LMFBR subassembly by redistributing coolant flow so as to reduce the maximum cladding temperature and increase the duct wall temperature. The reduced cladding temperatures are offset by strain concentrations resulting from the fin geometry, so there is little net effect on predicted fuel pin performance. The increased duct wall temperatures, however, significantly reduce the duct design lifetime so that the final conclusion is that the integral fin design is inferior to the standard wire wrap design. This result, however, is dependent upon the material correlations used. Advanced alloys with improved irradiation properties could alter this conclusion
Thermal performance analysis and optimum design parameters of heat exchanger having perforated pin fins

International Nuclear Information System (INIS)

Sahin, Bayram; Demir, Alparslan

2008-01-01

This paper reports the heat transfer enhancement and corresponding pressure drop over a flat surface equipped with circular cross section perforated pin fins in a rectangular channel. The channel had a cross section area of 100-250 mm 2 . The experiments covered the following ranges: Reynolds number 13500-42,000, clearance ratio (C/H) 0, 0.33 and 1 and interfin spacing ratio (S y /D) 1.208, 1.524, 1.944 and 3.417. Correlation equations were developed for the heat transfer, friction factor and enhancement efficiency. The experimental results showed that the use of circular cross section pin fins may lead to heat transfer enhancement. Enhancement efficiencies varied between 1.4 and 2.6 depending on clearance ratio and interfin spacing ratio. Using a Taguchi experimental design method, optimum design parameters and their levels were investigated. Nusselt number and friction factor were considered as performance parameters. An L 9 (3 3 ) orthogonal array was selected as an experimental plan. First of all, each goal was optimized separately. Then, all the goals were optimized together, considering the priority of the goals, and the optimum results were found to be Reynolds number of 42,000, fin height of 50 mm and streamwise distance between fins of 51 mm
Experimental study of flow friction characteristics of integral pin-fin tubes

International Nuclear Information System (INIS)

Ding Ming; Yan Changqi; Sun Licheng

2007-01-01

Friction characteristics of integral pin-fin tubes, through which lubricating-oil flowed vertically, were studied experimentally. Effects of the pitch, the height of fins and the machining direction on friction coefficient were analyzed. The experimental results showed that the friction coefficient of the integral pin-fro tube was obviously lager than that of smooth tube. Compared with other influential factors, the effect of the height of fins was dominant. Because the three-dimensional pin fin could disturb and destroy the boundary layer, when the Reynolds Number reached 200-300, the friction coefficient curve began to bend, that was, a turning point was appeared in the friction coefficient curve. (authors)
Comprehensive study of flow and heat transfer at the surface of circular cooling fin

Science.gov (United States)

Mityakov, V. Yu; Grekov, M. A.; Gusakov, A. A.; Sapozhnikov, S. Z.; Seroshtanov, V. V.; Bashkatov, A. V.; Dymkin, A. N.; Pavlov, A. V.; Milto, O. A.; Kalmykov, K. S.

2017-11-01

For the first time is proposed to combine heat flux measurements with thermal imaging and PIV (particle image velocimetry) for a comprehensive study of flow and heat transfer at the surface of the circular cooling fin. The investigated hollow fin is heated from within with saturated water steam; meanwhile the isothermal external surface simulates one of the perfect fin. Flow and heat transfer at the surface of the solid fin of the same size and shape, made of titanium alloy is investigated in the same regimes. Gradient Heat Flux Sensors (GHFS) were installed at different places of the fin surface. Velocity field around a cylinder, temperature field at the surface of the fin and heat flux for each rated time were obtained. Comprehensive method including heat flux measurement, PIV and thermal imaging allow to study flow and heat transfer at the surface of the fin in real time regime. The possibility to study flow and heat transfer for non-isothermal fins is shown; it is allow to improve traditional calculation of the cooling fins.
Dinosaurios de la Península Ibérica

Directory of Open Access Journals (Sweden)

Sanz, J. L.

2006-12-01

aspectos de la historia evolutiva del grupo y, dada la posición de la Península Ibérica, para la interpretación de la distribución de muchos de sus componentes. El registro ibérico cuenta con representantes de casi todos los grandes grupos de dinosaurios: ornitópodos, tireóforos, terópodos y saurópodos, que están bien representados, sobre todo en el tránsito Jurásico-Cretácico (Kimmeridgiense-Berriasiewe, en parte del Cretácico Inferior (Barremiense-Aptiense y en el final del Cretácico Superior (Campaniense-Maastrichtiense. El conjunto de ornitisquios está compuesto por tireóforos, de los que se han identificado dos estegosaurios (Dacentrurus y Stegosaurus y tres anquilosaurios (Dracopelta, Polacanthus y Struthiosaurus y ornitópodos: hipsilofodóntidos, iguanodontia basales (Rhabdodon; driosáuridos, camptosáuridos (Draconyx y Camptosaurus, iguanodontoideos (Iguanodon y hadrosáuridos(Pararhabdodon. Además existe un gran número de formas de asignación dudosa o aún por describir. El registro de saurópodos está fundamentalmente compuesto por formas cercanas al nodo Neosauropoda (Lourinhasaurus, Dinheirosaurus, Galveosaurus y Losillasaurus y titanosauriformes (Aragosaurus, Lusotitan y Lirainosaurus, además de una serie de formas nuevas en fase de descripción, como los saurópodos de Riodeva (Teruel, Peñarroya de Tastavins (Teruel y Morella (Castellón. El conjunto de géneros de terópodos ibéricos está constituido por el ceratosaurio Ceratosaurus, el espinosauroide Torvosaurus, los carnosaurios Lourinhanosaurus y Allosaurus, el tiranosauroide Aviatyrannis, el ornitomimosaurio Pelecanimimus, y los terópodos avianos Iberomesornis, Concornis, Eoalulavis y Noguerornis. Sin embargo, la diversidad de terópodos es mucho mayor, como muestra la abundante colección de morfotipos dentarios identificados.
Performance investigation of an innovative offset strip fin arrays in compact heat exchangers

International Nuclear Information System (INIS)

Peng, Hao; Ling, Xiang; Li, Juan

2014-01-01

Highlights: • The effect of fin pitch, length and bending distance on thermal performance were presented. • The corresponding Re C values at the j and f slope changes are in the range of 2000–2100. • The numerical results showed a good agreement with the experimental data. • Local high Nu values near the channel inlet, decreasing through the flow directions. - Abstract: Experimental and numerical studies on the flow and heat transfer characteristics for an innovative offset strip fins compact heat exchangers were performed. First, five fin schemes were investigated with various air flow velocities and a constant inlet steam pressure by experiments. The Reynolds number ranged from 500 to 5000 at the air side. The experimental results indicated that the fin pitch (P f ), fin length (L f ) and fin bending distance (C f ) have a significant influence on thermal performance of fins. The Colburn factor j, friction factor f and ‘point of transition’ were calculated from the experimental data. Then, the thermal–hydraulic performances of the novel offset strip fins were analyzed numerically. The simulation results obtained are in agreement with experimental data. Based on these simulations, the maximum values for local Nu number are at the channel inlet which is due to the thermal entrance effect. The longitudinal vortexes near the fin region will increase velocity gradient and reduce the thickness of boundary layer to improve heat transfer. The main conclusion draws from this work will be helpful for future development and design of a high-efficiency heat exchangers involving offset strip fin structures

Thermoelectric generator with hinged assembly for fins

International Nuclear Information System (INIS)

Purdy, D.L.; Shapiro, Z.M.; Hursen, T.F.; Maurer, G.W.

1976-01-01

A cylindrical casing has a central shielded capsule of radioisotope fuel. A plurality of thermonuclear modules are axially arranged with their hot junctions resiliently pressed toward the shield and with their cold junctions adjacent a transition member having fins radiating heat to the environment. For each module, the assembly of transition member and fins is hinged to the casing for swinging to permit access to and removal of such module. A ceramic plate having gold layers on opposite faces prevents diffusion bonding of the hot junction to the shield
Heat transfer enhancement of phase change materials by fins under simultaneous charging and discharging

International Nuclear Information System (INIS)

Joybari, Mahmood Mastani; Haghighat, Fariborz; Seddegh, Saeid; Al-Abidi, Abduljalil A.

2017-01-01

Highlights: • CFD simulation of a finned triplex tube heat exchanger with PCM under simultaneous charging and discharging. • Developed fin configurations for SCD, compatible with natural convection. • More fins enhanced the heat transfer as long as natural convection was not suppressed. • Longer fins enhanced the heat transfer as long as natural convection was not suppressed. • The effect of fin thickness was negligible, similar to non-SCD conditions. - Abstract: Due to the inherent intermittency of renewable energy sources such as solar, latent heat thermal energy storage in phase change materials (PCMs) has received considerable attention. Among several techniques to enhance PCMs’ thermal conductivity, the majority of studies have focused on fin integration due to its simplicity, ease of manufacturing, and low cost. In this study, utilization of extended surfaces (by longitudinal fins) was investigated by development of a numerical model to study the performance of a triplex tube heat exchanger (TTHX) equipped with a PCM under simultaneous charging and discharging (SCD). Governing equations were developed and numerically solved using ANSYS Fluent v16.2. Three conventional fin geometries and six developed fin configurations were compared based on the temperature, liquid fraction, and natural convection behavior under both SCD and non-SCD conditions. The intensity of natural convection was investigated for different fins for the inside heating/outside cooling scenario based on the solid–liquid interface evolution over time. The results indicated that since the buoyancy forces induce upward melted PCM motion, the inner hot tube requires fins on its lower half, while the outer cold one should be extended from its upper half. It was concluded that the case with 3 hot tube fins and 1 cold tube fin is most compatible with natural convection and provides the best performance under SCD conditions.
Trastuzumab in early stage breast cancer: a cost-effectiveness analysis for Belgium.

Science.gov (United States)

Neyt, Mattias; Huybrechts, Michel; Hulstaert, Frank; Vrijens, France; Ramaekers, Dirk

2008-08-01

Although trastuzumab is traditionally used in metastatic breast cancer treatment, studies reported on the efficacy and safety of trastuzumab in adjuvant setting for the treatment of early stage breast cancer in HER2+ tumors. We estimated the cost-effectiveness and budget impact of reimbursing trastuzumab in this indication from a payer's perspective. We constructed a health economic model. Long-term consequences of preventing patients to progress to metastatic breast cancer and side effects such as congestive heart failure were taken into account. Uncertainty was handled applying probabilistic modeling and through probabilistic sensitivity analyses. In the HERA scenario, applying an arbitrary threshold of euro30000 per life-year gained, early stage breast cancer treatment with trastuzumab is cost-effective for 9 out of 15 analyzed subgroups (according to age and stage). In contrast, treatment according to the FinHer scenario is cost-effective in 14 subgroups. Furthermore, the FinHer regimen is most of the times cost saving with an average incremental cost of euro668, euro-1045, and euro-6869 for respectively stages I, II and III breast cancer patients whereas the HERA regimen is never cost saving due to the higher initial treatment costs. The model shows better cost-effectiveness for the 9-week initial treatment (FinHer) compared to no trastuzumab treatment than for the 1-year post-chemotherapy treatment (HERA). Both from a medical and an economic point of view, the 9-week initial treatment regimen with trastuzumab shows promising results and justifies the initiation of a large comparative trial with a 1-year regimen.
Resolution of ray-finned fish phylogeny and timing of diversification.

Science.gov (United States)

Near, Thomas J; Eytan, Ron I; Dornburg, Alex; Kuhn, Kristen L; Moore, Jon A; Davis, Matthew P; Wainwright, Peter C; Friedman, Matt; Smith, W Leo

2012-08-21

Ray-finned fishes make up half of all living vertebrate species. Nearly all ray-finned fishes are teleosts, which include most commercially important fish species, several model organisms for genomics and developmental biology, and the dominant component of marine and freshwater vertebrate faunas. Despite the economic and scientific importance of ray-finned fishes, the lack of a single comprehensive phylogeny with corresponding divergence-time estimates has limited our understanding of the evolution and diversification of this radiation. Our analyses, which use multiple nuclear gene sequences in conjunction with 36 fossil age constraints, result in a well-supported phylogeny of all major ray-finned fish lineages and molecular age estimates that are generally consistent with the fossil record. This phylogeny informs three long-standing problems: specifically identifying elopomorphs (eels and tarpons) as the sister lineage of all other teleosts, providing a unique hypothesis on the radiation of early euteleosts, and offering a promising strategy for resolution of the "bush at the top of the tree" that includes percomorphs and other spiny-finned teleosts. Contrasting our divergence time estimates with studies using a single nuclear gene or whole mitochondrial genomes, we find that the former underestimates ages of the oldest ray-finned fish divergences, but the latter dramatically overestimates ages for derived teleost lineages. Our time-calibrated phylogeny reveals that much of the diversification leading to extant groups of teleosts occurred between the late Mesozoic and early Cenozoic, identifying this period as the "Second Age of Fishes."
Combined natural convection heat and mass transfer from vertical fin arrays

International Nuclear Information System (INIS)

Giri, A.; Narasimham, G.S.V.L.; Krishna Murthy, M.V.

2003-01-01

Natural convection transport processes play an important role in many applications like ice-storage air-conditioning. A mathematical formulation of natural convection heat and mass transfer over a shrouded vertical fin array is developed. The base plate is maintained at a temperature below the dew point of the surrounding moist air. Hence there occurs condensation of moisture on the base plate, while the fins may be partially or fully wet. A numerical study is performed by varying the parameters of the problem. The local and average Nusselt numbers decrease in streamwise direction and tend to approach fully developed values for sufficiently large values of the fin length. The results show that beyond a certain streamwise distance, further fin length does not improve the sensible and latent heat transfer performance, and that if dry fin analysis is used under moisture condensation conditions, the overall heat transfer will be underestimated by about 50% even at low buoyancy ratios
Optimization of convective-radiative fins by using differential quadrature element method

International Nuclear Information System (INIS)

Malekzadeh, P.; Rahideh, H.; Karami, G.

2006-01-01

A first endeavor to exploit the differential quadrature element method (DQEM) as a simple, accurate and computationally efficient numerical tool for the shape optimization of convective-radiating extended surfaces or fins is made. The formulations are general so that the spatial and spatial-temperature dependent geometrical and thermal parameters can easily be implemented. The thermal conductivity of the fin is assumed to vary as a linear function of the temperature. The effects of a convective-radiative condition at the fin tip and effective convective condition at the fin base are considered. The optimization of fins with uniform and step cross-sections is investigated. The accuracy of the method is demonstrated by comparing its results with those generated by Adomian's decomposition technique, Taylor transformation technique and finite difference method. It is shown that, using few grid points, highly accurate results are obtained. Less computational effort of the method with respect to the finite difference method is shown
Numerical simulation of a plate-fin heat exchanger with offset fins using porous media approach

Science.gov (United States)

Juan, Du; Hai-Tao, Zhao

2018-03-01

In this paper, the study was focused on a double flow plate-fin heat exchanger (PFHE) whose heat transfer element was offset staggered fin. Numerical simulations have been carried out to investigate the thermodynamic characteristics of a full-size PFHE via the porous media approach. Based on the numerical model, the effects of the dynamic viscosity and the locations of the inlet and outlet tubes on flow distribution and pressure drop of the PFHE were studied. The results showed that flow distribution of the PFHE was improved by increasing the dynamic viscosity. Therefore, the relationship between flow distribution and pressure drop was analyzed under various inlet velocity, and a correlation among flow distribution, pressure drop, and Reynolds number was derived. Finally, the middle-based strategy was proposed and numerically verified to improve flow distribution of the PFHE.
Numerical Modeling of Transient Heat Transfer in Longitudinal Fin

Directory of Open Access Journals (Sweden)

Farshad Panahizadeh

2017-11-01

Full Text Available The main objective of the present numerical study is to investigate the transient heat transfer in one kind of all-purpose longitudinal fin with the triangular profile. The lateral surface of the concerned fin and the tip of it are subjected to general situations included heat flux at the base and insulation on the tip. For this study developed a one dimensional in house code written by Fortran 90 programming language by using finite difference method with an implicit scheme in unsteady state condition. Generally, the result of this study in time variation state after 700 seconds is steady. The results also show the fin efficiency by increasing the time of study decreases due to a reduction in the total heat transfer which is happened in the fin. The grid independence study shows that for the number of nodes greater than 20 the result will not be changed and same as before. Finally, the result of Fortran code verified by commercial CFD code which relies on finite difference method and it was shown have a consistent agreement
Effect of storage media and time on fin explants culture in the ...

African Journals Online (AJOL)

The effect of storage media and time was investigated on fin explants culture in the goldfish (Carassius auratus). Fin explants under sterile conditions were able to produce cells at different storage media and time. On the outgrowth of cells, fin explants stored for seven days before culturing showed significantly higher growth ...
Caudal fin allometry in the white shark Carcharodon carcharias: implications for locomotory performance and ecology

Science.gov (United States)

Lingham-Soliar, Theagarten

2005-05-01

Allometric scaling analysis was employed to investigate the consequences of size evolution on hydrodynamic performance and ecology in the white shark Carcharodon carcharias. Discriminant analysis using the power equation y=axb was negative for caudal fin span (S) versus fork length (FL) in C. carcharias. In contrast in two delphinid species, Delphinus capensis and Tursiops aduncus, the span of the flukes versus fork length rises in positive allometric fashion, and strong positive allometry of S versus √A (area) was also recorded. The latter reflects a high lift/drag ratio. S versus √A in C. carcharias displays negative allometry and consequently a lower lift/drag ratio. A lower aspect ratio (AR) caudal fin in C. carcharias compared to that of the delphinids (mean 3.33 and 4.1, respectively) and other thunniform swimmers provides the potential for better maneuverability and acceleration. The liver in sharks is frequently associated with a buoyancy function and was found to be positively allometric in C. carcharias. The overall findings suggest that the negatively allometric caudal fin morphometrics in C. carcharias are unlikely to have deleterious evolutionary fitness consequences for predation. On the contrary, when considered in the context of positive liver allometry in C. carcharias it is hereby suggested that buoyancy may play a dominant role in larger white sharks in permitting slow swimming while minimizing energy demands needed to prevent sinking. In contrast hydrodynamic lift is considered more important in smaller white sharks. Larger caudal fin spans and higher lift/drag ratio in smaller C. carcharias indicate greater potential for prolonged, intermediate swimming speeds and for feeding predominantly on fast-moving fish, in contrast to slow-swimming search patterns of larger individuals for predominantly large mammalian prey. Such data may provide some answers to the lifestyle and widespread habitat capabilities of this still largely mysterious animal.
A thermal study of pipes with outer transverse fins

Directory of Open Access Journals (Sweden)

S. Gil

2016-10-01

Full Text Available This paper provides results of thermal investigations on pipes with outer transverse fins produced by placing a strip, being a form of helical spring which functions as a radiator, on the basis pipe. The investigations were carried out at the facility that enables measurements with respect to both natural and forced convection. Performance of the investigated pipes was assessed in relation to a non-finned pipe and a pipe welded with the use of Metal Active Gas (MAG technology. The experiments have shown that the finned pipe welding technology does not markedly affect their thermal efficiency, which has been confirmed by performed model calculations, while the welding technology has a crucial impact on their operating performance.
Experimental and numerical analysis of the optimized finned-tube heat exchanger for OM314 diesel exhaust exergy recovery

International Nuclear Information System (INIS)

Hatami, M.; Ganji, D.D.; Gorji-Bandpy, M.

2015-01-01

Highlights: • An optimized finned-tube heat exchanger is modeled. • Artificial Neural Networks and Genetic Algorithm are applied. • Exergy recovery from exhaust of a diesel engine is studied. - Abstract: In this research, a multi objective optimization based on Artificial Neural Network (ANN) and Genetic Algorithm (GA) are applied on the obtained results from numerical outcomes for a finned-tube heat exchanger (HEX) in diesel exhaust heat recovery. Thirty heat exchangers with different fin length, thickness and fin numbers are modeled and those results in three engine loads are optimized with weight functions for pressure drop, recovered heat and HEX weight. Finally, two cases of HEXs (an optimized and a non-optimized) are produced experimentally and mounted on the exhaust of an OM314 diesel engine to compare their results in heat and exergy recovery. All experiments are done for five engine loads (0%, 20%, 40%, 60% and 80% of full load) and four water mass flow rates (50, 40, 30 and 20 g/s). Results show that maximum exergy recovers occurs in high engine loads and optimized HEX with 10 fins have averagely 8% second law efficiency in exergy recovery
Quasiparticle propagation in aluminum fins and tungsten TES dynamics in the CDMS ZIP detector

Energy Technology Data Exchange (ETDEWEB)

Pyle, M. [Department of Physics, Stanford University, Stanford, CA 94305 (United States)]. E-mail: mpyle1@stanford.edu; Brink, P.L. [Department of Physics, Stanford University, Stanford, CA 94305 (United States); Cabrera, B. [Department of Physics, Stanford University, Stanford, CA 94305 (United States); Castle, J.P. [Department of Physics, Stanford University, Stanford, CA 94305 (United States); Colling, P. [Department of Physics, Stanford University, Stanford, CA 94305 (United States); Chang, C.L. [Department of Physics, Stanford University, Stanford, CA 94305 (United States); Cooley, J. [Department of Physics, Stanford University, Stanford, CA 94305 (United States); Lipus, T. [Department of Physics, Stanford University, Stanford, CA 94305 (United States); Ogburn, R.W. [Department of Physics, Stanford University, Stanford, CA 94305 (United States); Young, B.A. [Department of Physics, Santa Clara University, Santa Clara, CA 95053 (United States)

2006-04-15

With the aim of improving the rejection of surface beta contamination on the CDMS ZIP detector, we have studied the effectiveness of our phonon pulse-shape discrimination by matching a Monte Carlo calculation to data from a 350{mu}m long Al fin with W TESs (Transition-Edge Sensors) at both ends. From this fit, we determined the Al film diffusivity to be D{sub Al}=0.010+/-0.001m{sup 2}/s, the quasiparticle trapping length in the Al fin to be l{sub trap}=180+/-10{mu}m, and the Al to W TES transmission to be f{sub Al/W}=0.002+/-0.001.
Characteristics of a micro-fin evaporator: Theoretical analysis and experimental verification

OpenAIRE

Zheng Hui-Fan; Fan Xiao-Wei; Wang Fang; Liang Yao-Hua

2013-01-01

A theoretical analysis and experimental verification on the characteristics of a micro-fin evaporator using R290 and R717 as refrigerants were carried out. The heat capacity and heat transfer coefficient of the micro-fin evaporator were investigated under different water mass flow rate, different refrigerant mass flow rate, and different inner tube diameter of micro-fin evaporator. The simulation results of the heat transfer coefficient are fairly in good a...
Optimization design of LED heat dissipation structure based on strip fins

Science.gov (United States)

Xue, Lingyun; Wan, Wenbin; Chen, Qingguang; Rao, Huanle; Xu, Ping

2018-03-01

To solve the heat dissipation problem of LED, a radiator structure based on strip fins is designed and the method to optimize the structure parameters of strip fins is proposed in this paper. The combination of RBF neural networks and particle swarm optimization (PSO) algorithm is used for modeling and optimization respectively. During the experiment, the 150 datasets of LED junction temperature when structure parameters of number of strip fins, length, width and height of the fins have different values are obtained by ANSYS software. Then RBF neural network is applied to build the non-linear regression model and the parameters optimization of structure based on particle swarm optimization algorithm is performed with this model. The experimental results show that the lowest LED junction temperature reaches 43.88 degrees when the number of hidden layer nodes in RBF neural network is 10, the two learning factors in particle swarm optimization algorithm are 0.5, 0.5 respectively, the inertia factor is 1 and the maximum number of iterations is 100, and now the number of fins is 64, the distribution structure is 8*8, and the length, width and height of fins are 4.3mm, 4.48mm and 55.3mm respectively. To compare the modeling and optimization results, LED junction temperature at the optimized structure parameters was simulated and the result is 43.592°C which approximately equals to the optimal result. Compared with the ordinary plate-fin-type radiator structure whose temperature is 56.38°C, the structure greatly enhances heat dissipation performance of the structure.
A novel louvered fin design to enhance thermal and drainage performances during periodic frosting/defrosting conditions

International Nuclear Information System (INIS)

Kim, Min-Hwan; Kim, Hisuk; Kim, Dong Rip; Lee, Kwan-Soo

2016-01-01

Highlights: • Thermal and drainage performances of a novel design louvered fin were investigated. • The thermal performance of the asymmetric fin was improved in the re-frosting cycle. • The asymmetric louvered fin exhibited better drainage on the leading edge of fins. • Lower surface tension between fin surface and water droplet improved the drainage. - Abstract: The retention water on fin surface can significantly degrade the thermal performance of heat exchangers under periodic frosting/defrosting conditions, which also leads to a decrease in the energy efficiency of air-source heat pumps. A novel louvered fin design was suggested to improve the drainage and the thermal performance of heat exchanger. The novel louvered fin had an asymmetric louver arrangement by flattening two louvers on the leading edge. The retention water formed on fin surface markedly decreased the heat transfer rate of the conventional symmetric louvered fins in re-frosting cycles. On the other hand, the asymmetric louvered fins improved the drainage performance of the retention water, which enhanced the heat transfer rate. To identify the reason of the difference in drainage performance between two fin geometries, additional experiments were carried out with enlargement models. The improvement in drainage performance of the asymmetric fin design originated from the lowered surface tension between the fin surface and water droplet.
Enhancement of heat transfer from a continuously moving porous fin exposed in convective–radiative environment

International Nuclear Information System (INIS)

Bhanja, Dipankar; Kundu, Balaram; Aziz, Abdul

2014-01-01

Highlights: • Analytical model for thermal analysis of moving porous fins. • Heat transfer from the fin surface due to convection and radiation. • For practical design aspects, optimization analysis was carried out. • Comparative study was made between the solid and porous moving fins. • Porous moving fin has more heat transfer ability than the stationary fin. - Abstract: In the present article, an exercise has been devoted to establish an analytical model for the determination of temperature distribution, fin efficiency and optimum design parameters of a porous moving fin which is losing heat by simultaneous convection and radiation to its surroundings. For the adaptation of this consideration, the governing equation becomes highly nonlinear. An analytical technique called Adomian decomposition method (ADM) is proposed for the solution methodology. The accuracy of the analytic solution is validated by using a numeric scheme called finite difference method. The results indicate that the numerical data and analytical approach are in agreement with each other. As the present study is an analytic, it is extended to the analysis for determination of optimum dimensions of said fin by satisfying either the maximization of rate of heat transfer for a given fin volume or by the minimization of fin volume for a desired heat transfer rate. The study is further extended to the porous fin in stationary condition and it is found that porous fin in moving condition transfers more heat than stationary condition. Investigation has also been made on solid moving fin to compare the outcomes of these parameters
Effects of gut-directed hypnotherapy on IBS in different clinical settings-results from two randomized, controlled trials.

Science.gov (United States)

Lindfors, Perjohan; Unge, Peter; Arvidsson, Patrik; Nyhlin, Henry; Björnsson, Einar; Abrahamsson, Hasse; Simrén, Magnus

2012-02-01

Gut-directed hypnotherapy has been found to be effective in irritable bowel syndrome (IBS). However, randomized, controlled studies are rare and few have been performed outside highly specialized research centers. The objective of this study was to study the effect of gut-directed hypnotherapy in IBS in different clinical settings outside the traditional research units. The study population included IBS patients refractory to standard management. In study 1, patients were randomized to receive gut-directed hypnotherapy (12 sessions, 1 h/week) in psychology private practices or supportive therapy, whereas patients were randomized to receive gut-directed hypnotherapy in a small county hospital or to serve as waiting list controls in study 2. Gastrointestinal symptom severity and quality of life were evaluated at baseline, at 3 months follow-up and after 1 year. We randomized 138 IBS patients refractory to standard management, 90 in study 1 and 48 in study 2. In both the studies, IBS-related symptoms were improved at 3 months in the gut-directed hypnotherapy groups (Phypnotherapy group than in the control group (Phypnotherapy is an effective treatment alternative for patients with refractory IBS, but the effectiveness is lower when the therapy is given outside the highly specialized research centers.
Genetic recombination and Cryptosporidium hominis virulent subtype IbA10G2.

Science.gov (United States)

Li, Na; Xiao, Lihua; Cama, Vitaliano A; Ortega, Ynes; Gilman, Robert H; Guo, Meijin; Feng, Yaoyu

2013-10-01

Little is known about the emergence and spread of virulent subtypes of Cryptosporidium hominis, the predominant species responsible for human cryptosporidiosis. We conducted sequence analyses of 32 genetic loci of 53 C. hominis specimens isolated from a longitudinally followed cohort of children living in a small community. We identified by linkage disequilibrium and recombination analyses only limited genetic recombination, which occurred exclusively within the 60-kDa glycoprotein gene subtype IbA10G2, a predominant subtype for outbreaks in industrialized nations and a virulent subtype in the study community. Intensive transmission of virulent subtype IbA10G2 in the study area might have resulted in genetic recombination with other subtypes. Moreover, we identified selection for IbA10G2 at a 129-kb region around the 60-kDa glycoprotein gene in chromosome 6. These findings improve our understanding of the origin and evolution of C. hominis subtypes and the spread of virulent subtypes.
Comparison of Temporal Parameters of Swimming Rescue Elements When Performed Using Dolphin and Flutter Kick with Fins - Didactical Approach

Science.gov (United States)

Rejman, Marek; Wiesner, Wojciech; Silakiewicz, Piotr; Klarowicz, Andrzej; Abraldes, J. Arturo

2012-01-01

The aim of this study was an analysis of the time required to swim to a victim and tow them back to shore, while perfoming the flutter-kick and the dolphin-kick using fins. It has been hypothesized that using fins while using the dolphin-kick when swimming leads to reduced rescue time. Sixteen lifeguards took part in the study. The main tasks performed by them, were to approach and tow (double armpit) a dummy a distance of 50m while applying either the flutter-kick, or the dolphin-kick with fins. The analysis of the temporal parameters of both techniques of kicking demonstrates that, during the approach to the victim, neither the dolphin (tmean = 32.9s) or the flutter kick (tmean = 33.0s) were significantly faster than the other. However, when used for towing a victim the flutter kick (tmean = 47.1s) was significantly faster when compared to the dolphin-kick (tmean = 52.8s). An assessment of the level of technical skills in competitive swimming, and in approaching and towing the victim, were also conducted. Towing time was significantly correlated with the parameter that linked the temporal and technical dimensions of towing and swimming (difference between flutter kick towing time and dolphin-kick towing time, 100m medley time and the four swimming strokes evaluation). No similar interdependency has been discovered in flutter kick towing time. These findings suggest that the dolphin-kick is a more difficult skill to perform when towing the victim than the flutter-kick. Since the hypothesis stated was not confirmed, postulates were formulated on how to improve dolphin-kick technique with fins, in order to reduce swimming rescue time. Key points The source of reduction of swimming rescue time was researched. Time required to approach and to tow the victim while doing the flutter kick and the dolphin-kick with fins was analyzed. The propulsion generated by dolphin-kick did not make the approach and tow faster than the flutter kick. More difficult skill to realize of

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